locus_tag old_locus_tag gene Name start end strand product note type ID NCBI SCO0001 SCO0001 SCEND.02c SCEND.02c 446 1123 + hypothetical protein SCEND.02c%2C unknown%2C doubtful CDS%2C len: 225aa gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0001 SCO0002 SCO0002 SC8E7.42c SC8E7.42c 1252 3813 + hypothetical protein SCEND.01c%2C unknown%2C partial CDS%2C len: >27aa%3B strongly similar to TR:AAF36550 (EMBL:AF194023) helicase-like protein from Streptomyces lividans (881 aa) fasta scores%3B opt: 114%2C z-score: 206.0%2C E(): 0.00052%2C 80.0%25 identity in 25 aa overlap.~SCJ24.01c%2C unknown%2C partial CDS%2C len: >457aa%3B strongly similar to TR:AAF36550 (EMBL:AF194023) helicase-like protein from Streptomyces lividans (881 aa) fasta scores%3B opt: 2191%2C z-score: 2490.1%2C E(): 0%2C 72.5%25 identity in 458 aa overlap.~SC8E7.42c%2C partial CDS%2C unknown%2C len:> 431 aa. Highly similar to Streptomyces lividans TR:AAF36550(EMBL:AF194023) helicase-like protein found in the chromosome terminal region (881 aa)%2C fasta scores opt: 1940 z-score: 2170.3 E():0 66.9%25 identity in 438 aa overlap. gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0002 SCO0003 SCO0003 SC8E7.41c SC8E7.41c 3869 6220 + DNA-binding protein SC8E7.41c%2C possible DNA-binding protein%2C len: 783 aa. Contains a helix-turn-helix motif situated between residues 69..90 (+3.17 SD). gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0003 SCO0004 SCO0004 SC1C9.01 SC1C9.01 6226 7173 + hypothetical protein SC8E7.40c%2C unknown%2C len: 315 aa.~SC1C9.01%2C hypothetical protein (fragment)%2C len: >64 aa%3B identical to C-terminal part of TR:Q9FBV5 (EMBL:AL391338) Streptomyces coelicolor hypothetical 33.7 kDa protein SC8E7.40c%2C 315 aa%2C situated on the opposite end of the chromosome gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0004 SCO0005 SCO0005 SC1C9.02 SC1C9.02 7187 9307 + transposase SC1C9.02%2C possible transposase%2C len: 706 aa%3B identical to TR:Q9FBV6 (EMBL:AL391338) Streptomyces coelicolor transposase SC9E7.39c%2C 706 aa%2C situated on the opposite end of the chromosome. Contains Pfam match to entry PF00665 rve%2C Integrase core domain gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0005 SCO0006 SCO0006 SC1C9.03 SC1C9.03 9304 10410 + ATP/GTP-binding protein SC1C9.03%2C possible ATP/GTP-binding protein (fragment)%2C len: >223 aa%3B identical to N-terminal part of TR:Q9FBV7 (EMBL:AL391338) Streptomyces coelicolor ATP/GTP-binding protein%2C 368 aa%3B situated on the opposite end of the chromosome. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop)~SCJ30.01%2C partial CDS%2C unknown%2C len: >183 aa%3B weakly similar to the C-terminal half of suspected transposition related nucleotide binding proteins eg. TR:Q57461 (EMBL:U49101) TniB delta1 from plasmid pVS1 (286 aa) fasta scores%3B opt: 133%2C z-score: 170.1%2C E(): 0.041%2C (29.7%25 identity in 148 aa overlap). gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0006 SCO0007 SCO0007 SCJ30.02c SCJ30.02c 10554 11000 - hypothetical protein SCJ30.02c%2C unknown%2C len: 148 aa gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0007 SCO0008 SCO0008 SCJ30.03c SCJ30.03c 11010 11360 - hypothetical protein SCJ30.03c%2C unknown%2C len: 116 aa gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0008 SCO0009 SCO0009 SCJ30.04c SCJ30.04c 11617 11952 - hypothetical protein SCJ30.04c%2C improbable CDS%2C function unknown%2C len: 111 aa%3B predicted by GC frameplot and amino acid usage. gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0009 SCO0010 SCO0010 SCJ30.05 SCJ30.05 12366 13457 + hypothetical protein SCJ30.05%2C unknown (hypothetical protein)%2C len: 362 aa%3B region of similarity to TR:CAB41280 (EMBL:AL049707) transferase from Streptomyces coelicolor (448 aa) fasta scores%3B opt: 411%2C z-score: 409.4%2C E(): 1.9e-15%2C (32.8%25 identity in 274 aa overlap). Contains leucine TTA codon%2C possible target for bldA regulation. Note large overlap with downstream CDS. gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0010 SCO0011 SCO0011 SCJ30.06c SCJ30.06c 13214 14023 - hypothetical protein SCJ30.06c%2C unknown%2C len: 269 aa%3B predicted amino acid usage. Note large overlap with downstream CDS. gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0011 SCO0012 SCO0012 SCJ30.07c SCJ30.07c 14044 14454 - hypothetical protein SCJ30.07c%2C unknown%2C len: 136 aa%3B predicted by GC Frameplot%2C Hidden Markov model and amino acid usage. gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0012 SCO0013 SCO0013 SCJ30.09c SCJ30.09c 14739 15029 - hypothetical protein SCJ30.09c%2C unknown%2C len: 96 aa%3B predicted by GC Frameplot%2C Hidden Markov model and amino acid usage%3B similar to the C-terminal region of the SCP1 plasmid borne TR:Q9ACW6 (EMBL:AL590464) Streptomyces coelicolor conserved hypothetical protein SCP1.185%2C 184 aa%3B fasta scores: opt: 442 Z-score: 592.9 E(): 2.1e-25%3B 84.615%25 identity in 78 aa overlap gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0013 SCO0014 SCO0014 SCJ30.10c SCJ30.10c 15317 15595 - hypothetical protein SCJ30.10c%2C unknown%2C len: 92 aa%3B predicted by GC Frameplot%2C Hidden Markov model and amino acid usage%3B highly similar to the SCP1 plasmid borne TR:Q9ACW7 (EMBL:AL590464) Streptomyces coelicolor conserved hypothetical protein SCP1.184%2C 92 aa%3B fasta scores: opt: 499 Z-score: 653.4 E(): 9.2e-29%3B 81.522%25 identity in 92 aa overlap. Contains leucine TTA codon%2C possible target for bldA regulation gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0014 SCO0015 SCO0015 SCJ30.11c SCJ30.11c 16070 17302 - Na+/H+ antiporter SCJ30.11c%2C possible Na+/H+ antiporter%2C len: 410 aa%3B similar to many eg. TR:Q56580 (EMBL:D25214) Na+/H+ antiporter from Vibrio alginolyticus (383 aa) fasta scores%3B opt: 536%2C z-score: 594.7%2C E(): 9.1e-26%2C (38.5%25 identity in 384 aa overlap). Also similar to TR:CAB38501 (EMBL:AL035636) Na+/H+ antiporter from Streptomyces coelicolor (474 aa) fasta scores%3B opt: 968%2C z-score: 1067.2%2C E(): 0%2C (52.2%25 identity in 404 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0015 SCO0016 SCO0016 SCJ30.12 SCJ30.12 17715 17918 + hypothetical protein SCJ30.12%2C unknown%2C len: 67 aa%3B predicted by GC Frameplot%2C Hidden Markov model and amino acid usage. gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0016 SCO0017 SCO0017 SCJ30.13 SCJ30.13 17919 18263 + hypothetical protein SCJ30.13%2C unknown%2C len: 114 aa%3B predicted by GC Frameplot%2C Hidden Markov model and amino acid usage. gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0017 SCO0018 SCO0018 SCJ30.14c SCJ30.14c 18485 19351 - hypothetical protein SCJ30.14c%2C hypothetical protein%2C len: 228 aa%3B predicted by GC Frameplot%2C Hidden Markov model and amino acid usage. Has regions of similarity to SCJ4.39 hypothetical protein from the overlapping Streptomyces coelicolor cosmid J4 (EMBL:AL109950) fasta scores%3B opt: 334%2C z-score: 359.9%2C E(): 8.2e-15%2C (41.6%25 identity in 245 aa overlap). gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0018 SCO0019 SCO0019 SCJ30.15c SCJ30.15c 19517 19771 - hypothetical protein SCJ30.15c%2C improbable CDS%2C function unknown%2C len: 115 aa%3B predicted by amino acid usage. gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0019 SCO0020 SCO0020 SCJ30.16 SCJ30.16 19974 21620 + transposase SCJ4.01%2C partial CDS%2C possible transposase%2C len: >183 aa%3B similar to TR:Q9R2U8(EMBL:AL133236) transposase from Streptomyces coelicolor (501 aa) fasta scores%2C opt: 267 z-score: 317.3 E(): 3.4e-10 33.9%25 identity in 168 aa overlap and TR:O69919 (EMBL:AL023861) hypothetical protein from Streptomyces coelicolor (188 aa) fasta scores%3B opt: 419%2C z-score: 501.4%2C E(): 1.4e-20%2C (45.9%25 identity in 159 aa overlap). Overlaps and extends into CDS SCJ30.16 on the adjoining cosmid.~SCJ30.16%2C partial CDS%2C possible transposase%2C len: >397 aa%3B varying regions and lengths of similarity to many eg. SW:TRA1_BORPA transposase from IS1001 of Bordetella parapertussis (406 aa) fasta scores%3B opt: 203%2C z-score: 236.1%2C E(): 8.7e-06%2C (28.4%25 identity in 215 aa overlap). Also contains short region of similarity to TR:O69919 (EMBL:AL023861) hypothetical protein from Streptomyces coelicolor (188 aa) fasta scores%3B opt: 248%2C z-score: 292.3%2C E(): 6.4e-09%2C (68.1%25 identity in 47 aa overlap). Contains possible helix-turn-helix motif (+4.11 SD) 308-329 aa. Also contains TTA leucine%2C possible target for bldA regulation. gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0020 SCO0021 SCO0021 SCJ4.02 SCJ4.02 21617 22210 + hypothetical protein SCJ4.02%2C unknown%2C len: 197 aa gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0021 SCO0022 SCO0022 SCJ4.03c SCJ4.03c 22156 22761 - IS element ATP-binding protein SCJ4.03c%2C partial CDS%2C possible IS element ATP-binding protein%2C len: 47 aa%3B similar to regions of many eg. SW:ISTB_ECOLI IS element ATP-binding protein from Escherichia coli (265 aa) fasta scores%3B opt: 132%2C z-score: 207.1%2C E(): 0.00035%2C (53.8%25 identity in 39 aa overlap). Also similar to TR:O69925 (EMBL:AL023861) IS element ATP-binding protein from Streptomyces coelicolor (256 aa) fasta scores%3B opt: 224%2C z-score: 343.7%2C E(): 8.7e-12%2C (72.3%25 identity in 47 aa overlap)~SCJ4.04c%2C partial CDS%2C possible IS element ATP-binding protein%2C len: 47aa%3B similar to regions of many eg. SW:ISTB_ECOLI IS element ATP-binding protein from Escherichia coli (265 aa) fasta scores%3B opt: 193%2C z-score: 314.5%2C E(): 3.7e-10%2C (55.3%25 identity in 47 aa overlap). Also similar to TR:O69925 (EMBL:AL023861) IS element ATP-binding protein from Streptomyces coelicolor (256 aa) fasta scores%3B opt: 273%2C z-score: 440.0%2C E(): 3.8e-17%2C (91.5%25 identity in 47 aa overlap).~SCJ4.05c%2C partial CDS%2C possible IS element ATP-binding protein%2C len: 46aa%3B similar to regions of many eg. SW:ISTB_ECOLI IS element ATP-binding protein from Escherichia coli (265 aa) fasta scores%3B opt: 150%2C z-score: 245.0%2C E(): 2.7e-06%2C (43.5%25 identity in 46 aa overlap). Also similar to TR:O69925 (EMBL:AL023861) IS element ATP-binding protein from Streptomyces coelicolor (256 aa) fasta scores%3B opt: 250%2C z-score: 400.5%2C E(): 6e-15%2C (78.3%25 identity in 46 aa overlap). gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0022 SCO0025 SCO0025 SCJ4.06 SCJ4.06 22843 23061 + IS element ATP-binding protein SCJ4.06%2C partial CDS%2C possible IS element ATP-binding protein%2C len: 46aa%3B similar to regions of many eg. TR:BAA78797 (EMBL:AP000342) NTP-binding protein from IS element of plasmid R100 (261 aa) fasta scores%3B opt: 113%2C z-score: 154.6%2C E(): 0.3%2C (36.4%25 identity in 55 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0025 SCO0026 SCO0026 SCJ4.07 SCJ4.07 23316 23831 + hypothetical protein SCJ4.07%2C possible hypothetical protein%2C len: 171 aa%3B Contains possible N-terminal signal sequence. Also contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0026 SCO0027 SCO0027 SCJ4.08c SCJ4.08c 23977 24345 - hypothetical protein SCJ4.08c%2C doubtful CDS%2C function unknown%2C len: 122 aa gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0027 SCO0028 SCO0028 SCJ4.09c SCJ4.09c 24378 24521 - hypothetical protein SCJ4.09c%2C doubtful CDS%2C function unknown%2C len: 47 aa gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0028 SCO0029 SCO0029 SCJ4.10 SCJ4.10 24644 24943 + hypothetical protein SCJ4.10%2C unknown%2C len: 99 aa gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0029 SCO0030 SCO0030 SCJ4.11 SCJ4.11 25251 25871 + hypothetical protein SCJ4.11%2C unknown%2C len: 206 aa%3B similar in its N-terminal region to the SCP1 plasmid borne TR:Q9ACQ7 (EMBL:AL590464) Streptomyces coelicolor hypothetical protein SCP1.261c%2C 167 aa%3B fasta scores: opt: 478 Z-score: 480.3 E(): 4e-19%3B 74.766%25 identity in 107 aa overlap gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0030 SCO0031 SCO0031 SCJ4.12c SCJ4.12c 25843 26385 - hypothetical protein SCJ4.12c%2C unknown%2C len: 180 aa gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0031 SCO0033 SCO0033 SCJ4.14c SCJ4.14c 26527 28773 - neuraminidase SCJ4.14c%2C possible neuraminidase (sialidase)%2C len: 748 aa%3B similar to many%2C both prokaryote and eukaryote%2C egs. SW:NANH_MICVI sialidase precusor from Micromonospora viridifaciens (647 aa) fasta scores%3B opt: 274%2C z-score: 299.9%2C E(): 2.4e-09%2C (28.6%25 identity in 587 aa overlap) and TR:O35657 (EMBL:Y11412) G9 sialidase precusor from Mus musculus (Mouse) (409 aa) fasta scores%3B opt: 325%2C z-score: 358.5%2C E(): 1.3e-12%2C (26.6%25 identity in 425 aa overlap). Also similar to TR:Q9ZBW1 (EMBL:AL034443) neuraminidase from Streptomyces coelicolor (648 aa) fasta scores%3B opt: 479%2C z-score: 524.0%2C E(): 7.9e-22%2C (33.5%25 identity in 638 aa overlap). Contains possible N-terminal signal sequence. gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0033 SCO0034 SCO0034 SCJ4.15 SCJ4.15 29040 29519 + hypothetical protein SCJ4.15%2C unknown%2C len: 159 aa gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0034 SCO0035 SCO0035 SCJ4.16c SCJ4.16c 29605 30054 - hypothetical protein SCJ4.16c%2C unknown%2C len: 149 aa gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0035 SCO0036 SCO0036 SCJ4.17c SCJ4.17c 30116 30355 - hypothetical protein SCJ4.17c%2C unknown%2C len: 79 aa%3B weak similarity to TR:Q48505 (EMBL:M63292%3B) beta-lactamase (fragment) from Lactococcus lactis subsp. lactis (87 aa) fasta scores%3B opt: 91%2C z-score: 133.7%2C E(): 4.4%2C (31.8%25 identity in 66 aa overlap). gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0036 SCO0037 SCO0037 SCJ4.18c SCJ4.18c 30379 31131 - sigma factor SCJ4.18c%2C possible sigma factor%2C len: 250 aa%3B similar to many proposed sigma factors e.g. TR:CAB44418 (EMBL:AL078610) sigma factor from Streptomyces coelicolor (223 aa) fasta scores%3B opt: 419%2C z-score: 506.3%2C E(): 7.7e-21%2C (44.3%25 identity in 183 aa overlap) and SW:SIGY_BACSU RNA polymerase sigma factor%2C SigY from Bacillus subtilis (178 aa) fasta scores%3B opt: 111%2C z-score: 142.5%2C E(): 1.4%2C (23.9%25 identity in 117 aa overlap). Note possible framshift from previous CDS as similar to all but the N-terminus of TR:CAB42013 (EMBL:AL049754) RNA polymerase sigma factor from Streptomyces coelicolor (294 aa) fasta scores%3B opt: 270%2C z-score: 327.8%2C E(): 6.7e-11%2C (26.9%25 identity in 238 aa overlap) while SCJ4.19c is similar to the N-terminus. Contains possible helix-turn-helix motif (+3.23 SD) 91-112 aa gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0037 SCO0038 SCO0038 SCJ4.19c SCJ4.19c 31146 31274 - sigma factor SCJ4.19c%2C partial CDS%2C possible sigma factor%2C len: 24 aa%3B similar to the N-terminus of TR:CAB42013 (EMBL:AL049754) RNA polymerase sigma factor from Streptomyces coelicolor (294 aa) fasta scores%3B opt: 105%2C z-score: 185.5%2C E(): 0.0056%2C (50.0%25 identity in 32 aa overlap) and may frameshift into the downstream CDS (SCJ4.18c) which is similar to the remainder. gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0038 SCO0039 SCO0039 SCJ4.20 SCJ4.20 31520 32137 + hypothetical protein SCJ4.20%2C unknown%2C len: 205 aa%3B similar to the N-terminal region of TR:O53411 (EMBL:AL021897) hypothetical protein from Mycobacterium tuberculosis (360 aa) fasta scores%3B opt: 165%2C z-score: 190.9%2C E(): 0.0028%2C (34.1%25 identity in 135 aa overlap). gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0039 SCO0040 SCO0040 SCJ4.21 SCJ4.21 32134 33357 + glycosyl transferase SCJ4.21%2C possible glycosyl transferase%2C len: 407 aa%3B similar to many e.g. TR:O86304 (EMBL:AJ223970) macrolide glycosyl transferase from Streptomyces ambofaciens (417 aa) fasta scores%3B opt: 615%2C z-score: 696.4%2C E(): 2e-31%2C (34.3%25 identity in 405 aa overlap). Contains Pfam match to entry PF00201 UDPGT%2C UDP-glucoronosyl and UDP-glucosyl transferases. gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0040 SCO0041 SCO0041 SCJ4.22 SCJ4.22 33360 33845 + hypothetical protein SCJ4.22%2C possible integral membrane protein%2C len: 161 aa%3B contains possible membrane spanning hydrophobic regions. gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0041 SCO0042 SCO0042 SCJ4.23 SCJ4.23 33842 34777 + hypothetical protein SCJ4.23%2C unknown%2C len: 311 aa gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0042 SCO0043 SCO0043 SCJ4.24c SCJ4.24c 35179 35907 - hypothetical protein SCJ4.24c%2C unknown%2C len: 242 aa%3B weakly similar to several hypothetical proteins eg. TR:O86850 (EMBL:AJ007731) from Streptomyces coelicolor (284 aa) fasta scores%3B opt: 167%2C z-score: 198.4%2C E(): 0.0011%2C (31.7%25 identity in 224 aa overlap). gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0043 SCO0044 SCO0044 SCJ4.25c SCJ4.25c 36006 36674 - oxidoreductase SCJ4.25c%2C probable oxidoreductase%2C len: 222 aa%3B similar to many e.g. SW:NOX_THETH NADH dehydrogenase from Thermus thermophilus (205 aa) fasta scores%3B opt: 169%2C z-score: 215.5%2C E(): 0.00012%2C (27.7%25 identity in 220 aa overlap). Contains Pfam match to entry PF00881 Nitroreductase%2C Nitroreductase family gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0044 SCO0045 SCO0045 SCJ4.26c SCJ4.26c 36689 36817 - hypothetical protein SCJ4.26c%2C unknown%2C len: 42 aa gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0045 SCO0046 SCO0046 SCJ4.27 SCJ4.27 36816 37478 + hydrolase gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0046 SCO0047 SCO0047 SCJ4.28c SCJ4.28c 37614 38768 - transcriptional regulator SCJ4.28c%2C possible transcriptional regulator%2C len: 384 aa%3B C-terminal similar to many transcriptional regulator eg. SW:SLYA_ECOLI transcriptional regulator from Escherichia coli (146 aa) fasta scores%3B opt: 156%2C z-score: 184.9%2C E(): 0.0061%2C (24.6%25 identity in 122 aa overlap). Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0047 SCO0048 SCO0048 SCJ4.29c SCJ4.29c 39107 39490 - hypothetical protein SCJ4.29c%2C unknown%2C len: 127 aa gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0048 SCO0049 SCO0049 SCJ4.30 SCJ4.30 39489 39812 + hypothetical protein SCJ4.30%2C unknown%2C len: 107 aa gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0049 SCO0050 SCO0050 SCJ4.31 SCJ4.31 39877 40212 + hypothetical protein SCJ4.31%2C hypothetical protein%2C len: 111 aa%3B region of similarity to many respiratory electron transport chain proteins eg. TR:O49078 (EMBL:AF037456) cytochrome B6-F complex iron-sulphur subunit from Fritillaria agrestis (230 aa) fasta scores%3B opt: 104%2C z-score: 143.7%2C E(): 1.2%2C (32.8%25 identity in 67 aa overlap). gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0050 SCO0051 SCO0051 SCJ4.32c SCJ4.32c 40223 40918 - gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0051 SCO0053 SCO0053 SCJ4.34 SCJ4.34 41354 42174 + gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0053 SCO0055 SCO0055 SCJ4.36c SCJ4.36c 42171 43682 - membrane-associated oxidoreductase SCJ4.36c%2C possible membrane-associated oxidoreductase%2C len: 503aa%3B N-terminal region similar to TR:Q53931 (EMBL:X64420) HisD L-histidinol:NAD oxidoreductase from Streptomyces coelicolor (203 aa) fasta scores%3B opt: 345%2C z-score: 401.6%2C E(): 5.2e-15%2C (35.6%25 identity in 177 aa overlap). Also similar to TR:O88013 (EMBL:AL031107) hypothetical protein from Streptomyces coelicolor (527 aa) fasta scores%3B opt: 684%2C z-score: 783.6%2C E(): 0%2C (37.0%25 identity in 525 aa overlap) gene gene49 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0055 SCO0056 SCO0056 SCJ4.37 SCJ4.37 43768 43857 + hypothetical protein SCJ4.37%2C unknown%2C len: 29 aa gene gene50 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0056 SCO0057 SCO0057 SCJ4.38 SCJ4.38 43950 44090 + hypothetical protein SCJ4.38%2C unknown%2C len: 46 aa gene gene51 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0057 SCO0058 SCO0058 SCJ4.39 SCJ4.39 44253 44975 + hypothetical protein SCJ4.39%2C unknown%2C len: 240 aa gene gene52 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0058 SCO0059 SCO0059 SCJ4.40 SCJ4.40 45267 46073 + zinc-binding oxidoreductase SCJ4.40%2C possible zinc-binding oxidoreductase%2C len: 268 aa%3B similar to many both prokaryote and eukaryote egs. TR:O85702 (EMBL:AF072709) oxidoreductase from Streptomyces lividans 66 (313 aa) fasta scores%3B opt: 494%2C z-score: 509.6%2C E(): 5e-21%2C (41.3%25 identity in 240 aa overlap) and SW:QOR_CAVPO quinone oxidoreductase from Cavia porcellus (guinea pig) (329 aa) fasta scores%3B opt: 397%2C z-score: 411.5%2C E(): 1.5e-15%2C (32.8%25 identity in 244 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0059 SCO0060 SCO0060 SCJ4.41 SCJ4.41 46064 46201 + hypothetical protein SCJ4.41%2C unknown%2C len: 45 aa%3B predicted by GC Frameplot and amino acid usage. gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0060 SCO0061 SCO0061 SCJ4.42c SCJ4.42c 46430 47734 - hypothetical protein SCJ4.42c%2C unknown%2C len: 434 aa%3B similar to SW:YDEG_SCHPO hypothetical protein from Schizosaccharomyces pombe (fission yeast) (509 aa) fasta scores%3B opt: 665%2C z-score: 791.0%2C E(): 0%2C (37.6%25 identity in 423 aa overlap) and to TR:Q9KEQ9 (EMBL:AP001509) Bacillus halodurans BH0790 protein%2C 454 aa%3B fasta scores: opt: 1262 Z-score: 1468.0 bits: 280.8 E(): 3.9e-74%3B 45.433%25 identity in 416 aa overlap gene gene55 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0061 SCO0062 SCO0062 SCJ4.43c SCJ4.43c 47789 48892 - LacI family transcriptional regulator SCJ4.43c%2C probable LacI family transcriptional regulator%2C len: 367 aa%3B similar to many transcriptional regulators e.g. SW:GALR_ECOLI galactose operon repressor (343 aa) fasta scores%3B opt: 549%2C z-score: 636.2%2C E(): 4.5e-28%2C (32.5%25 identity in 332 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family. Contains possible helix-turn-helix motif (+3.86 SD) 26-47. gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0062 SCO0063 SCO0063 SCJ4.44c SCJ4.44c 48889 49824 - glucokinase SCJ4.44c%2C possible glucokinase%2C len: 311 aa%3B similar to many eg. SW:GLK_STRCO glucokinase from Streptomyces coelicolor (317 aa) fasta scores%3B opt: 175%2C z-score: 195.7%2C E(): 0.0015%2C (28.2%25 identity in 326 aa overlap). Contains Pfam match to entry PF00480 ROK%2C ROK family gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0063 SCO0064 SCO0064 SCJ4.45c SCJ4.45c 49821 51539 - hypothetical protein SCJ4.45c%2C unknown%2C len: 572 aa gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0064 SCO0065 SCO0065 SCJ4.46 SCJ4.46 51831 53144 + extracellular binding protein SCJ4.46%2C possible extracellular binding protein%2C part of a possible binding protein dependent transport system%2C len: 437 aa%3B similar to many egs. TR:Q9Z492 (EMBL:AF043654) BxlE%2C extracellular binding protein from Streptomyces lividans (434 aa) fasta scores%3B opt: 256%2C z-score: 290.5%2C E(): 8.1e-09%2C (23.3%25 identity in 446 aa overlap) and SW:YC14_PYRHO hypothetical ABC transporter extracellular binding protein from Pyrococcus horikoshii OT3 (441 aa) fasta scores%3B opt: 348%2C z-score: 393.3%2C E(): 1.5e-14%2C (25.4%25 identity in 343 aa overlap). Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site so may be anchored by lipid. gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0065 SCO0066 SCO0066 SCJ4.47 SCJ4.47 53141 54100 + integral membrane permease SCJ4.47%2C possible integral membrane permease%2C part of a possible binding protein dependent transport system%2C len: 319 aa%3B similar to many eg. SW:LACF_AGRRD lactose transport system permease from Agrobacterium radiobacter (298 aa) fasta scores%3B opt: 460%2C z-score: 522.1%2C E(): 1e-21%2C (30.5%25 identity in 272 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0066 SCO0067 SCO0067 SCJ4.48 SCJ4.48 54097 54918 + integral membrane permease SCJ4.48%2C probable integral membrane permease%2C len: 273 aa%3B similar to many e.g. TR:Q9Z3R7 (EMBL:AF045609) inner membrane permease from the alpha-glucosides binding protein dependent transport system of Rhizobium (Sinorhizobium) meliloti (305 aa) fasta scores%3B opt: 393%2C z-score: 457.6%2C E(): 4e-18%2C (32.3%25 identity in 229 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains possible membrane spanning hydrophobic regions. gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0067 SCO0068 SCO0068 SCJ4.49 SCJ4.49 54968 56173 + hydrolase SCJ4.49%2C possible hydrolase (hypothetical protein)%2C len: 401aa%3B N-terminal region similar to that of TR:Q9Z4P9 (EMBL:AB024331) alpha-1%2C6-D-mannanase from Bacillus circulans (589 aa) fasta scores%3B opt: 218%2C z-score: 251.2%2C E(): 1.2e-06%2C (26.2%25 identity in 229 aa overlap) gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0068 SCO0069 SCO0069 SCJ4.50 SCJ4.50 56225 59383 + hypothetical protein SCJ4.50%2C unknown%2C len: 1052 aa gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0069 SCO0070 SCO0070 SCJ4.51 SCJ4.51 59558 60241 + hypothetical protein SCJ4.51%2C unknown%2C possibly involved in sugar metabolism%2C len: 22 aa%3B similar over region to many hypothetical sugar metabolism proteins e.g. SW:VIPB_SALTI polysaccharide biosynthesis protein from Salmonella enterica (348 aa) fasta scores%3B opt: 220%2C z-score: 251.9%2C E(): 1.1e-06%2C (31.8%25 identity in 170 aa overlap). Note overlap with downstream gene. gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0070 SCO0071 SCO0071 SCJ4.52c SCJ4.52c 60069 60275 - hypothetical protein SCJ4.52c%2C unknown%2C len: 68 aa%3B predicted by GC Frameplot and amino acid usage. Note overlap with downstream gene. gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0071 SCO0072 SCO0072 SCJ11.01c SCJ11.01c 60740 64093 - hypothetical protein SCJ4.53c%2C partial CDS%2C unknown%2C len: >356 aa%3B similar to many of undefined function e.g. SW:WAPA_BACSU wall associated protein from Bacillus subtilis (2334 aa) fasta scores%3B opt: 322%2C z-score: 315.0%2C E(): 3.5e-10%2C (27.5%25 identity in 320 aa overlap).~SCJ11.01c%2C partial CDS%2C possible hypothetical protein%2C len: >793 aa gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0072 SCO0073 SCO0073 SCJ11.02 SCJ11.02 64605 64925 + hypothetical protein SCJ11.02%2C unknown%2C len: 106 aa gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0073 SCO0074 SCO0074 SCJ11.03 SCJ11.03 64994 65092 + hypothetical protein SCJ11.03%2C unknown%2C len: 32 aa gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0074 SCO0075 SCO0075 SCJ11.04 SCJ11.04 65092 65679 + hypothetical protein SCJ11.04%2C unknown%2C len: 195 aa%3B weakly similar to SW:KILB_STRLI KilB protein from Streptomyces lividans plasmid pIJ101 thought to be involved in plasmid transfer (147 aa) fasta scores%3B opt: 126%2C z-score: 152.9%2C E(): 0.37%2C (27.5%25 identity in 142 aa overlap). Contains probable coiled-coil region approx. 25-45aa. Contains TTA encode leucine%2C possible site for bldA regulation. gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0075 SCO0076 SCO0076 SCJ11.05c SCJ11.05c 65627 66535 - gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0076 SCO0079 SCO0079 SCJ11.08c SCJ11.08c 66688 67911 - integral membrane transport protein SCJ11.08c%2C possible integral membrane transport protein%2C len: 407 aa%3B similar to many e.g. TR:P72472 (EMBL:U63848) sensor protein homolog from Streptomyces lividans (410 aa) fasta scores%3B opt: 2533%2C z-score: 2742.9%2C E(): 0%2C (98.5%25 identity in 407 aa overlap) and TR:Q56147 (EMBL:U09991) chloramphenicol resistance protein from Streptomyces venezuelae (436 aa) fasta scores%3B opt: 559%2C z-score: 610.6%2C E(): 1.2e-26%2C (28.2%25 identity in 411 aa overlap). Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0079 SCO0080 SCO0080 SCJ11.09 SCJ11.09 68372 68887 + hypothetical protein SCJ11.09%2C unknown%2C len: 171 aa gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0080 SCO0081 SCO0081 SCJ11.10c SCJ11.10c 68914 69647 - gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0081 SCO0083 SCO0083 SCJ11.12 SCJ11.12 69799 70647 + transposase SCJ11.12%2C possible transposase%2C len: 282aa%3B N-terminal similar to SW:YI22_BURCE (147 aa) fasta scores%3B opt: 431%2C z-score: 529.9%2C E(): 3.7e-22%2C (54.6%25 identity in 119 aa overlap)%2C C-terminal similar to SW:YI21_BURCE (211 aa) fasta scores%3B opt: 700%2C z-score: 852.1%2C E(): 0%2C (61.4%25 identity in 166 aa overlap). SW:YI22_BURCE and SW:YI21_BURCE encode insertion element IS402 hypothetical protein from Pseudomonas cepacia. C-terminal also similar to TR:O69847 (EMBL:AL023702) insertion element IS1647 transposase from Streptomyces coelicolor (150 aa) fasta scores%3B opt: 440%2C z-score: 540.6%2C E(): 9.4e-23%2C (44.2%25 identity in 147 aa overlap). gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0083 SCO0084 SCO0084 SCJ11.13 SCJ11.13 70777 71235 + hypothetical protein SCJ11.13%2C hypothetical protein%2C len: 152 aa%3B similar to TR:Q9S1Q3 (EMBL:AL109972) Streptomyces coelicolor hypothetical protein SCJ9A.17%2C 175 aa%3B fasta scores: opt: 683 Z-score: 803.5 E(): 4e-37%3B 68.421%25 identity in 152 aa overlap gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0084 SCO0085 SCO0085 SCJ11.14c SCJ11.14c 71648 72139 - hypothetical protein SCJ11.14c%2C unknown%2C len: 163 aa%3B weak similarity to a region from many proposed DNA ligases eg. TR:CAB45581 (EMBL:AL079355) DNA ligase from Streptomyces coelicolor (355 aa) fasta scores%3B opt: 182%2C z-score: 228.5%2C E(): 2.3e-05%2C (32.6%25 identity in 132 aa overlap). gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0085 SCO0086 SCO0086 SCJ11.15c SCJ11.15c 72159 73097 - ribosylglycohydrolase SCJ11.15c%2C possible ribosylglycohydrolase ( hypothetical protein)%2C len: 312 aa%3B similar to SW:DRAG_RHORU (EMBL:X16187) ADP-ribosylglycohydrolase DraG from Rhodospirillum rubrum (294 aa) fasta scores%3B opt: 267%2C z-score: 299.5%2C E(): 2.5e-09%2C (31.1%25 identity in 283 aa overlap) gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0086 SCO0087 SCO0087 SCJ11.16c SCJ11.16c 73784 74833 - hypothetical protein SCJ11.16c%2C hypothetical protein%2C len: 349 aa%3B similar to TR:P97061 (EMBL:Z81324) hypothetical protein downstream of a beta-lactam regulatory protein in Streptomyces clavuligerus (338 aa) fasta scores%3B opt: 548%2C z-score: 613.6%2C E(): 8.1e-27%2C (40.6%25 identity in 330 aa overlap) gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0087 SCO0088 SCO0088 SCJ11.17c SCJ11.17c 74917 75876 - beta-lactamase SCJ11.17c%2C possible beta-lactamase%2C len: 319 aa%3B some similarity to many e.g. SW:BLAB_STRCI partially defined beta-lactamase regulatory protein from Streptomyces cacaoi (312 aa) fasta scores%3B opt: 196%2C z-score: 231.8%2C E(): 1.5e-05%2C (28.4%25 identity in 278 aa overlap) and SW:BLAC_BACLI beta-lactamase from Bacillus licheniformis (307 aa) fasta scores%3B opt: 123%2C z-score: 148.2%2C E(): 0.68%2C (24.3%25 identity in 267 aa overlap). Contains possible N-terminal signal sequence. gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0088 SCO0089 SCO0089 SCJ11.18 SCJ11.18 75856 76893 + transcriptional regulator SCJ11.18%2C probable LysR-family transcriptional regulator%2C len: 345 aa%3B similar to many e.g. SW:ALSR_BACSU ALS operon regulator from Bacillus subtilis (302 aa) fasta scores%3B opt: 507%2C z-score: 564.5%2C E(): 4.4e-24%2C (31.0%25 identity in 290 aa overlap). Note possible alternative start codons downstream. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and Prosite match to PS00044 Bacterial regulatory proteins%2C lysR family signature. gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0089 SCO0090 SCO0090 SCJ11.19c SCJ11.19c 76895 77314 - transposase SCJ11.19c%2C partial CDS%2C possible transposase%2C len: 140 aa%3B similar to SW:IS12_STRAL IS112 28%2C4 kD protein from Streptomyces albus (256 aa) fasta scores%3B opt: 349%2C z-score: 447.9%2C E(): 1.4e-17%2C (53.9%25 identity in 128 aa overlap). gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0090 SCO0091 SCO0091 SCJ11.20 SCJ11.20 77315 78271 + IS1652 transposase SCJ11.20%2C probable insertion element IS1652 transposase%2C len: 318 aa%3B similar to many e.g. TR:O86758 (EMBL:AL031035) transposase from Streptomyces coelicolor (318 aa) fasta scores%3B opt: 2217%2C z-score: 2566.4%2C E(): 0%2C (99.7%25 identity in 318 aa overlap). gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0091 SCO0092 SCO0092 SCJ11.21c SCJ11.21c 78489 78815 - gene gene83 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0092 SCO0095 SCO0095 SCJ11.24c SCJ11.24c 78983 79702 - hypothetical protein SCJ11.24c%2C hypothetical protein%2C part of noncomposite transposon%2C len: 239 aa%3B weakly similar to SW:YAFD_ECOLI hypothetical protein from Escherichia coli (259 aa) fasta scores%3B opt: 112%2C z-score: 130.4%2C E(): 6.7%2C (25.0%25 identity in 208 aa overlap). gene gene84 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0095 SCO0096 SCO0096 SCJ11.25c SCJ11.25c 79839 80690 - noncomposite transposon transposase SCJ11.25c%2C possible noncomposite transposon transposase%2C len: 283 aa%3B similar to many e.g. TR:O86758 (EMBL:AL031035) proposed transposase from Streptomyces coelicolor (318 aa) fasta scores%3B opt: 275%2C z-score: 330.3%2C E(): 4.9e-11%2C (32.7%25 identity in 278 aa overlap). gene gene85 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0096 SCO0097 SCO0097 SCJ11.26c SCJ11.26c 80845 81165 - hypothetical protein SCJ11.26c%2C possible integral membrane protein%2C len: 106 aa%3B contains possible membrane spanning hydrophobic regions. gene gene86 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0097 SCO0098 SCO0098 SCJ11.27c SCJ11.27c 81602 82441 - transposase SCJ11.27c%2C possible transposase%2C len: 279 aa%3B previously sequenced therefore identical to TR:Q9Z9H3 (EMBL:AB024596) transposase from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 1839%2C z-score: 2190.6%2C E(): 0%2C (99.6%25 identity in 279 aa overlap). Also similar to many others eg. TR:Q48339 (EMBL:M80805) from IS1031 of Acetobacter xylinum (278 aa) fasta scores%3B opt: 611%2C z-score: 732.8%2C E(): 0%2C (38.9%25 identity in 262 aa overlap). gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0098 SCO0099 SCO0099 SCJ11.28 SCJ11.28 82710 83518 + gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0099 SCO0101 SCO0101 SCJ11.30c SCJ11.30c 83516 83992 - hypothetical protein SCJ11.30c%2C unknown%2C len: 247 aa%3B similar to SW:YBFG_HAEIN hypothetical protein from Haemophilus influenzae (228 aa) fasta scores%3B opt: 374%2C z-score: 437.3%2C E(): 5.3e-17%2C (32.8%25 identity in 195 aa overlap). Contains TTA leucine codon%2C possible target for bldA regulation. gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0101 SCO0102 SCO0102 SCJ11.31 SCJ11.31 84893 85339 + hypothetical protein SCJ11.31%2C unknown%2C len: 148 aa gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0102 SCO0103 SCO0103 SCJ11.32 SCJ11.32 85336 86643 + flavohemoprotein SCJ11.32%2C probable flavohemoprotein%2C len: 435aa%3B C-terminal region similar to many with reductase and dioxygenase activities%2C typical of flavohemoproteins e.g. TR:Q9ZI75 (EMBL:AF039533) naphthalene dioxygenase reductase from Pseudomonas stutzeri (328 aa) fasta scores%3B opt: 369%2C z-score: 419.0%2C E(): 5.6e-16%2C (28.6%25 identity in 241 aa overlap). Also typical of flavohemoprotein%2C C-terminal region contains Pfam match to entry PF00175 oxidored_fad%2C Oxidoreductase FAD/NAD-binding domain and N-terminal region contains Pfam match to entry PF00042 globin%2C Globin. gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0103 SCO0104 SCO0104 SCJ11.33 SCJ11.33 86640 87311 + hydrolase SCJ11.33%2C possible hydrolase%2C len: 223aa%3B similar to TR:O54126 (EMBL:AL021529) NTP pyrophosphohydrolase from Streptomyces coelicolor (359 aa) fasta scores%3B opt: 223%2C z-score: 267.6%2C E(): 1.5e-07%2C (29.4%25 identity in 194 aa overlap). gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0104 SCO0105 SCO0105 SCJ11.34c SCJ11.34c 87907 88632 - endo-1%2C4-beta-xylanase SCJ11.34c%2C xlnC%2C endo-1%2C4-beta-xylanase ( hypothetical protein)%2C len: 241 aa%3B highly similar to many endo-1%2C4-beta-xylanases e.g. SW:XYNC_STRLI from Streptomyces lividans (240 aa) fasta scores%3B opt: 1605%2C z-score: 1785.1%2C E(): 0%2C (97.9%25 identity in 241 aa overlap) and SW:XYNA_BACSU from Bacillus subtilis (213 aa) fasta scores%3B opt: 813%2C z-score: 910.7%2C E(): 0%2C (58.8%25 identity in 221 aa overlap). Contains Pfam match to entry PF00457 Glyco_hydro_11%2C Glycosyl hydrolases family 11 and Prosite matches to PS00777 Glycosyl hydrolases family 11 active site signature 2 and PS00776 Glycosyl hydrolases family 11 active site signature 1 gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0105 SCO0106 SCO0106 SCJ11.35 SCJ11.35 89073 89465 + insertion element transposase SCJ11.35%2C possible noncomposite drug resistance transposon transposase%2C len: 185 aa%3B similar to many e.g. TR:O69927 (EMBL:AL023861) IS1648 transposase from Streptomyces coelicolor (141 aa) fasta scores%3B opt: 432%2C z-score: 565.7 E(): 3.8e-24%2C (47.8%25 identity in 136 aa overlap). gene gene94 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0106 SCO0107 SCO0107 SCJ11.36c SCJ11.36c 89486 90043 - aminoglycoside nucleotidyltransferase SCJ11.36c%2C possible noncomposite drug resistance transposon aminoglycoside nucleotidyltransferase%2C len: 185 aa%3B some similarity to many involved in antibiotic resistance e.g. TR:Q53702 (EMBL:J03947) lincosaminide nucleotidyltransferase from Staphylococcus aureus (161 aa) fasta scores%3B opt: 176%2C z-score: 229.0%2C E(): 2.1e-05%2C (28.4%25 identity in 148 aa overlap) gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0107 SCO0108 SCO0108 SCJ11.37 SCJ11.37 90242 90391 + hypothetical protein SCJ11.37%2C unknown%2C len: 49 aa gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0108 SCO0109 SCO0109 SCJ11.38c SCJ11.38c 90395 90865 - hypothetical protein SCJ11.38c%2C unknown%2C len: 156aa%3B shows similarity to human proteins involved in the expression of GAGE genes eg. TR:AAC33676 (EMBL:AF055473) GAGE-7 from Homo sapiens (Human) (116 aa) fasta scores%3B opt: 114%2C z-score: 144.7%2C E(): 1.1%2C (31.9%25 identity in 119 aa overlap). gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0109 SCO0110 SCO0110 SCJ11.39c SCJ11.39c 90951 91790 - DNA-binding protein SCJ11.39c%2C possible DNA-binding protein%2C len: 279 aa%3B similar to TR:O86721 (EMBL:AL031515) hypothetical protein from Streptomyces coelicolor (272 aa) fasta scores%3B opt: 123%2C z-score: 148.4%2C E(): 0.66%2C (26.6%25 identity in 278 aa overlap). Contains possible helix-turn-helix motif 40-61 aa (+3.21 SD) gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0110 SCO0111 SCO0111 SCJ11.40 SCJ11.40 91977 92729 + oxidoreductase SCJ11.40%2C probable oxidoreductase%2C len: 753 aa%3B similar to many egs. TR:O32457 (EMBL:D87924) ORF7 from the polyketide synthase cluster of Actinomadura hibisca (246 aa) fasta scores%3B opt: 480%2C z-score: 498.5%2C E(): 2.1e-20%2C (38.3%25 identity in 248 aa overlap) and TR:Q54810 (EMBL:L35560) reductase from the doxorubicin polyketide synthase cluster of Streptomyces peucetius (251 aa) fasta scores%3B opt: 408%2C z-score: 425.7%2C E(): 2.4e-16%2C (33.7%25 identity in 243 aa overlap). Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase and to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0111 SCO0112 SCO0112 SCJ11.41c SCJ11.41c 92773 92928 - hypothetical protein SCJ11.41c%2C improbable CDS%2C function unknown%2C len: 51aa%3B predicted by GC Frameplot. gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0112 SCO0113 SCO0113 SCJ11.42 SCJ11.42 92961 93257 + gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0113 SCO0114 SCO0114 SCJ11.43c SCJ11.43c 93292 94117 - gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0114 SCO0116 SCO0116 SCJ11.45c SCJ11.45c 94306 94872 - TetR family transcriptional regulator SCJ11.45c%2C possible tetR-family transcriptional regulator%2C len: 188 aa%3B N-terminal region similar to that of others e.g. SW:ACRR_ECOLI potential AcrAB operon repressor (215 aa) fasta scores%3B opt: 148%2C z-score: 188.9%2C E(): 0.0037%2C (39.3%25 identity in 61 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains possible helix-turn-helix motif 32-53aa (+3.34 SD). gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0116 SCO0117 SCO0117 SCJ11.46 SCJ11.46 94989 95681 + short chain dehydrogenase SCJ11.46%2C possible oxidoreductase%2C len: 230 aa%3B similar to many proposed oxidoreductases eg. TR:O53324 (EMBL:AL021646) oxidoreductase from Mycobacterium tuberculosis (235 aa) fasta scores%3B opt: 626%2C z-score: 717.5%2C E(): 1.3e-32%2C (50.9%25 identity in 224 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0117 SCO0118 SCO0118 SCJ11.47 SCJ11.47 95989 97518 + xylosidase/arabinosidase SCJ11.47%2C possible xylosidase/arabinosidase%2C len: 509aa%3B similar to many xylosidase/arabinosidases especially in the N-terminal xylosidase region e.g. SW:XYLB_BUTFI xylosidase/arabinosidase from Butyrivibrio fibrisolvens (517 aa) fasta scores%3B opt: 582%2C z-score: 640.5%2C E(): 2.6e-28%2C (35.2%25 identity in 526 aa overlap) gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0118 SCO0119 SCO0119 SCJ11.48c SCJ11.48c 97760 98281 - hypothetical protein SCJ11.48c%2C possible small hypothetical protein%2C len: 173aa%3B contains possible N-terminal signal sequence. gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0119 SCO0120 SCO0120 SCJ11.49c SCJ11.49c 98463 99338 - hypothetical protein SCJ21.01c%2C probable integral membrane protein%2C partial CDS%2C len: >114 aa~SCJ11.49c%2C probable integral membrane protein%2C len: >222aa%3B contains probable membrane spanning hydrophobic regions. gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0120 SCO0121 SCO0121 SCJ21.02c SCJ21.02c 99335 99949 - ABC transporter ATP-binding protein SCJ21.02c%2C probable ABC transport system ATP-binding protein%2C len: 204 aa%3B similar to many e.g. NUC_ECOLI high-affinity zinc uptake system ATP-binding protein (251 aa)%2C fasta scores%3B opt: 327 z-score: 404.3 E(): 3.6e-15%2C 35.2%25 identity in 179 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00005 ABC_tran%2C ABC transporter gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0121 SCO0122 SCO0122 SCJ21.03 SCJ21.03 100190 101566 + flavin-containing monooxygenase SCJ21.03%2C probable flavin-containing monooxygenase (hypothetical protein)%2C len: 458 aa%3B similar to many eukaryotic monooxygenases%2C e.g. FMO5_RABIT dimethylaniline monooxygenase [N-oxide forming] (532 aa)%2C fasta scores%3B opt: 938 z-score: 1016.9 E(): 0%2C 38.7%25 identity in 432 aa overlap. Also similar to S. coelicolor oxidoreductase SCH35.27 E(): 3.4e-07%2C 34.8%25 identity in 282 aa overlap. Contains Pfam match to entry PF00743 FMO-like%2C Flavin-binding monooxygenase-like gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0122 SCO0123 SCO0123 SCJ21.04c SCJ21.04c 101656 103002 - hypothetical protein SCJ21.04c%2C unknown%2C len: 448 aa%3B some similarity to M. tuberculosis hypothetical protein TR:P71694 (EMBL:Z95844) Rv1425 (459 aa)%2C fasta scores%3B opt: 150 z-score: 166.6 E(): 0.063%2C 23.9%25 identity in 464 aa overlap gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0123 SCO0124 SCO0124 SCJ21.05 SCJ21.05 103628 104989 + hypothetical protein SCJ21.05%2C unknown%2C len: 453 aa%3B similar in part to several polyketide synthases%2C e.g. HETM_ANASP polyketide synthase HETM (506 aa)%2C fasta scores%3B opt: 252 z-score: 267.0 E(): 1.6e-07%2C 33.7%25 identity in 199 aa overlap%2C and TR:Q50858 (EMBL:U24657) saframycin MX1 synthetase A (2605 aa)%2C fasta scores%3B opt: 244 z-score: 248.0 E(): 1.9e-06%2C 28.5%25 identity in 372 aa overlap. Contains TTA Leu codon%3B possible target for regulation by bldA gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0124 SCO0125 SCO0125 SCJ21.06 SCJ21.06 105057 106640 + oxidoreductase SCJ21.06%2C possible oxidoreductase%2C len: 527 aa%3B similar to hypothetical proteins associated with fatty acid or polyketide biosynthesis e.g. TR:O33907 (EMBL:U73935) hypothetical protein in eicosapentaenoic acid synthesis gene cluster from Shewanella sp. (543 aa)%2C fasta scores%3B opt: 1474 z-score: 1595.4 E(): 0%2C 48.1%25 identity in 472 aa overlap%3B and TR:Q44210 (EMBL:U04436) ORF in region required for nitrogen fixation in Anabaena 7120 (442 aa)%2C fasta scores%3B opt: 1395 z-score: 1511.4 E(): 0%2C 47.7%25 identity in 440 aa overlap. Also shows some similarity to predicted oxidoreductase from M. tuberculosis TR:O33323 oxidoreductase RV2781c (344 aa)%2C fasta scores%3B opt: 161 z-score: 179.6 E(): 0.012%2C 26.7%25 identity in 277 aa overlap gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0125 SCO0126 SCO0126 SCJ21.07 SCJ21.07 106637 112885 + beta keto-acyl synthase SCJ21.07%2C probable multi-domain beta keto-acyl synthase%2C len: 2082 aa%3B similar to proteins involved in fatty acid or polyketide biosynthesis e.g. TR:O30776 (EMBL:) heterocyst glycolipid synthase HglE (1053 aa)%2C fasta scores%3B opt: 2382 z-score: 1897.1 E(): 0%2C 41.6%25 identity in 1013 aa overlap%2C and TR:O54142 (EMBL:AL021530) S. coelicolor polyketide synthase RedX (982 aa)%2C fasta scores%3B opt: 910 z-score: 728.5 E(): 0%2C 37.4%25 identity in 494 aa overlap. Contains 2x Pfam matches to entry PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C and Pfam match to entry PF00550 pp-binding%2C Phosphopantetheine attachment site gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0126 SCO0127 SCO0127 SCJ21.08 SCJ21.08 112932 119654 + beta keto-acyl synthase SCJ21.08%2C probable multi-domain beta keto-acyl synthase%2C len: 2240 aa%3B similar to proteins involved in fatty acid or polyketide biosynthesis e.g. TR:Q44221 Anabaena sp. type 4 polyketide synthases HglD (fragment) (448 aa)%2C fasta scores%3B opt: 760 z-score: 639.3 E(): 2.9e-28%2C 38.0%25 identity in 392 aa overlap%3B MCAS_MYCBO mycocerosic acid synthase (2110 aa)%2C fasta scores opt: 707 z-score: 586.8 E(): 2.5e-25%2C 35.4%25 identity in 560 aa overlap%3B and TR:O54142 (EMBL:AL021530) S. coelicolor polyketide synthase RedX (982 aa)%2C opt: 658 z-score: 550.3 E(): 2.7e-23%2C 36.4%25 identity in 470 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C Pfam match to entry PF00698 Acyl_transf%2C Acyl transferase domain%2C and 2x Pfam matches to entry PF01377 Thioester_dehyd%2C Thioester dehydrase gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0127 SCO0128 SCO0128 SCJ21.09 SCJ21.09 119651 119833 + hypothetical protein SCJ21.09%2C unknown%2C len: 60 aa gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0128 SCO0129 SCO0129 SCJ21.10 SCJ21.10 119841 120215 + hypothetical protein SCJ21.10%2C unknown%2C len: 124 aa gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0129 SCO0130 SCO0130 SCJ21.11 SCJ21.11 120457 121371 + beta-lactamase SCJ21.11%2C possible beta-lactamase%2C len%3B 304 aa%3B some similarity to S. coelicolor TR:CAB39710 (EMBL:AL049485) beta-lactamase SC6A5.26C (310 aa)%2C fasta scores%3B opt: 197 z-score: 236.5 E(): 8e-06%2C 28.1%25 identity in 295 aa overlap%2C and TR:O34760 (EMBL:AF008220) Bacillus subtilis YtnP (256 aa)%2C fasta scores%3B opt: 189 z-score: 228.5 E(): 2.2e-05%2C 25.1%25 identity in 191 aa overlap and similar to TR:Q9ALW1 (EMBL:AF338729) Plesiomonas sp. M6 methyl parathion hydrolase Mpd%2C 331 aa%3B fasta scores: opt: 511 Z-score: 578.8 bits: 115.3 E(): 1.3e-24%3B 31.61%25 identity in 310 aa overlap gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0130 SCO0131 SCO0131 SCJ21.12c SCJ21.12c 121617 122456 - hypothetical protein SCJ21.12c%2C probable hypothetical protein%2C len: 279 aa%3B similar to hypothetical proteins e.g. YBHP_ECOLI (253 aa)%2C fasta scores%3B opt: 244 z-score: 290.0 E(): 8.4e-09%2C 29.5%25 identity in 251 aa overlap. Also similar to S. coelicolor TR:Q9ZBN3 (EMBL:AL034492) SC6C5.12C (276 aa)%2C fasta scores%3B opt: 474 z-score: 555.0 E(): 1.5e-23%2C 41.0%25 identity in 278 aa overlap gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0131 SCO0132 SCO0132 SCJ21.13 SCJ21.13 122743 125502 + transcriptional regulator SCJ21.13%2C probable transcriptional regulator%2C len: 919 aa%3B similar to many e.g. TR:AAD28307 (EMBL:U95170) Rhodococcus erythropolis ThcG (927 aa)%2C fasta scores%3B opt: 1176 z-score: 1258.4 E(): 0%2C 34.2%25 identity in 933 aa overlap%2C and TR:AAA53487 (EMBL:U03114) Streptomyces albus LipR (890 aa)%2C fasta scores%3B opt: 740 z-score: 791.4 E(): 0%2C 31.1%25 identity in 952 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C and probable helix-turn-helix motif at aa 871-892 (Score 1389%2C +3.92 SD) gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0132 SCO0133 SCO0133 SCJ21.14c SCJ21.14c 125625 126005 - hypothetical protein SCJ21.14c%2C unknown%2C len: 126 aa gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0133 SCO0134 SCO0134 SCJ21.15c SCJ21.15c 126989 127294 - hypothetical protein SCJ21.15c%2C unknown%2C len: 101 aa gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0134 SCO0135 SCO0135 SCJ21.16 SCJ21.16 127571 128290 + hypothetical protein SCJ21.16%2C unknown%2C len: 239 aa%3B similar to two hypothetical proteins from S. coelicolor TR:O86620 (EMBL:AL031155) SC3A7.19 (232 aa)%2C fasta scores%3B opt: 188 z-score: 222.0 E(): 5.1e-05%2C 33.6%25 identity in 238 aa overlap%2C and TR:Q9ZBN4 (EMBL:AL034492) SC6C5.11 (327 aa)%2C fasta scores%3B opt: 149 z-score: 176.2 E(): 0.018%2C 30.0%25 identity in 203 aa overlapand to TR:Q988L9 (EMBL:AP003009) Rhizobium loti MLR6684 protein%2C 259 aa%3B fasta scores: opt: 764 Z-score: 831.4 E(): 1.1e-38%3B 51.883%25 identity in 239 aa overlap gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0135 SCO0136 SCO0136 ulaA ulaA 128634 130184 - PTS system ascorbate-specific transporter subunit IIC membrane component%3B functions with enzymes IIB (sgaB%3B ulaB) and IIA (sgaA%3B ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate%3B sgaTBA are regulated by yifQ as well as Crp and Fnr gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0136 SCO0137 SCO0137 SCJ21.18c SCJ21.18c 130201 131001 - sugar-transport protein SCJ21.18c%2C unknown%2C partial CDS%2C len >170 aa~SCJ33.01c%2C sugar-transport protein%2C partial CDS%2C len: > 138 aa. Similar to many e.g. Escherichia coli SW: PTXA_ECOLI (EMBL%3B U14003) unknown pentitol phosphotransferase enzyme II%2C A component (EC 2.7.1.69) (154 aa)%2C fasta scores opt: 313 z-score: 403.6 E(): 4.1e-15 38.3%25 identity in 133 aa overlap. Overlaps with and extends into CDS SCJ21.18c. Contains a Pfam match to entry PF00359 PTS_EIIA_2%2C phosphoenolpyruvate-dependent sugar phosphotransferase system%2C EIIA 2. gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0137 SCO0138 SCO0138 SCJ33.02 SCJ33.02 131523 132296 + short chain dehydrogenase SCJ33.02%2C possible oxidoreductase%2C len: 257 aa. Similar to many other oxidoreductases including: Streptomyces cinnamonensis SW:DHKR_STRCM (EMBL%3B Z11511) monensin polyketide synthase ketoacyl reductase (EC 1.3.1.-) (261 aa)%2C fasta scores opt: 386 z-score: 426.3 E(): 2.2e-16 35.8%25 identity in 260 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0138 SCO0139 SCO0139 SCJ33.03 SCJ33.03 132327 132647 + hypothetical protein SCJ33.03%2C unknown%2C len: 106 aa. gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0139 SCO0140 SCO0140 SCJ33.04 SCJ33.04 132693 133520 + MerR family transcriptional regulator SCJ33.04%2C possible merR-family transcriptional regulator%2C len: 275 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB56383 (EMBL%3B AL118515) merR family transcriptional regulator SCD17.06C (319 aa)%2C fasta scores opt: 164 z-score: 194.6 E(): 0.0018 28.9%25 identity in 298 aa overlap and Bacillus subtilis SW:BLTR_BACSU (EMBL%3B L32599) multidrug-efflux transporter 2 regulator (273 aa)%2C fasta scores opt: 154 z-score: 184.2 E(): 0.0069 21.3%25 identity in 253 aa overlap. Contains a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family. Contains a possible helix-turn-helix motif located between residues 6..27 (+3.26 SD). gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0140 SCO0141 SCO0141 SCJ33.05c SCJ33.05c 133570 134121 - calcium-binding protein SCJ33.05c%2C possible calcium-binding protein%2C len: 183 aa. Weakly similar to many Eukaryotic calcium-binding proteins e.g. Drosophila melanogaster (Fruit fly) TR:O16158 (EMBL:AF014952) calcium-binding protein (184 aa)%2C fasta scores opt: 265 z-score: 323.1 E(): 1.2e-10 28.1%25 identity in 178 aa overlap. Contains a 4xPfam match to entry PF00036 efhand%2C EF hand. gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0141 SCO0142 SCO0142 SCJ33.06c SCJ33.06c 134295 136100 - hypothetical protein SCJ33.06c%2C unknown%2C len: 601 aa. Similar to the C-terminus of Mycobacterium tuberculosis hypothetical proteins SW:YS74_MYCTU (EMBL%3B Z74024) (695 aa)%2C fasta scores opt: 331 z-score: 375.0 E(): 1.6e-13 30.3%25 identity in 185 aa overlap and SW:YX05_MYCTU (EMBL%3B Z74024) (695 aa)%2C fasta scores opt: 331 z-score: 375.0 E(): 1.6e-13 30.3%25 identity in 185 aa overlap. Contains 5x Pfam match to entry PF01436 NHL%2C NHL repeat and possible membrane spanning hydrophobic domains gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0142 SCO0143 SCO0143 SCJ33.07 SCJ33.07 136647 137183 + hypothetical protein SCJ33.07%2C possible membrane protein%2C len: 162 aa. Similar to the N-terminus of an E. coli SW:YJGJ_ECOLI (EMBL%3B U14003) hypothetical 21.5 KD protein in PYRL-ARGI intergenic region (197 aa)%2C fasta scores opt: 199 z-score: 239.3 E(): 5.8e-06 41.3%25 identity in 75 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0143 SCO0144 SCO0144 SCJ33.08 SCJ33.08 137197 137556 + hypothetical protein SCJ33.08%2C unknown%2C len: 119 aa. gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0144 SCO0145 SCO0145 SCJ33.09 SCJ33.09 137561 138589 + hypothetical protein SCJ33.09%2C possible hypothetical protein%2C len: 342 aa. Similar to Streptomyces coelicolor TR:CAB45466 (EMBL%3B AL079348) hypothetical 33.9 KD protein SC66T3.10C (318 aa)%2C fasta scores opt: 272 z-score: 301.5 E(): 2e-09 34.0%25 identity in 300 aa overlap. Contains a TTA /leucine codon%2C possible target for bldA regulation. Contains a possible N-terminal signal sequence. gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0145 SCO0146 SCO0146 SCJ33.10c SCJ33.10c 138618 138761 - gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0146 SCO0147 SCO0147 SCJ33.11 SCJ33.11 138976 139467 + transmembrane transport protein SCJ33.11%2C possible transmembrane transport protein%2C len: 163 aa. Weakly similar to several including: Aquifex aeolicus TR:O66755 (EMBL%3B AE000690) MG(2+) transport ATPase (225 aa)%2C fasta scores opt: 110 z-score: 142.5 E(): 1.4 26.7%25 identity in 146 aa overlap and Bacillus subtilis TR:O31833 (EMBL%3B Z99114) YoaS protein (160 aa)%2C fasta scores opt:109 z-score: 143.2 E(): 1.3 25.0%25 identity in 148 aa overlap. Contains a Prosite hit to PS00211 ABC transporters family signature and Contains possible membrane spanning hydrophobic domains. gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0147 SCO0148 SCO0148 SCJ33.12 SCJ33.12 139467 139712 + transcriptional regulator SCJ33.12%2C possible transcriptional regulatory protein%2C len: 81 aa. Highly similar to Bacillus subtilis TR:O31834 (EMBL:Z99114) YozG protein (84 aa)%2C fasta scores opt: 307 z-score: 443.1 E(): 2.6e-17 61.8%25 identity in 68 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix which lies between residues 17..38 (+3.45 SD). gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0148 SCO0149 SCO0149 SCJ33.13c SCJ33.13c 139703 140299 - hypothetical protein SCJ33.13c%2C unknown%2C len: 198 aa. gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0149 SCO0150 SCO0150 SCJ33.14 SCJ33.14 140368 140862 + hypothetical protein SCJ33.14%2C unknown%2C len: 164 aa gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0150 SCO0151 SCO0151 SCJ33.15 SCJ33.15 141370 141708 + hypothetical protein SCJ33.15%2C possible integral membrane protein%2C len: 112 aa. Contains Contains possible membrane spanning hydrophobic domains. gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0151 SCO0152 SCO0152 SCJ1.01 SCJ1.01 141705 143315 + transmembrane transport protein SCJ1.01%2C possible transmembrane transport protein%2C partial CDS%2C len: >284 aa%3B similar to S. coelicolor transmembrane transport protein SC5B8.17 TR:O70003 (EMBL: AL022374) (530 aa)%2C fasta scores%3B opt: 513 z-score: 549.9 E(): 2.9e-23 38.1%25 identity in 270 aa overlap%2C Rhodobacter capsulatus transmembrane protein TR:O68042(EMBL: AF010496)(578 aa)%2C fasta scores opt: 243 z-score: 263.6 E(): 2.5e-07 26.3%25 identity in 281 aa overlap and Pseudomonas putida TR:O50471 (EMBL%3B Z71176) phenylacetic acid permease (520 aa)%2C fasta scores opt: 233 z-score: 253.6 E(): 9.1e-07 31.1%25 identity in 293 aa overlap. Contains probable membrane spanning hydrophobic domains.~SCJ33.16%2C possible transmembrane transport protein%2C partial CDS%2C len: >288 aa. Similar to several including: Pseudomonas putida TR:O50471 (EMBL%3B Z71176) phenylacetic acid permease (520 aa)%2C fasta scores opt: 337 z-score: 380.9 E(): 7.5e-14 29.4%25 identity in 269 aa overlap and Streptomyces coelicolor TR:O70003 (EMBL%3B AL022374) transmembrane transport SC5B8.17 (530 aa)%2C fasta scores opt: 462 z-score: 520.1 E(): 1.3e-21 31.9%25 identity in 279 aa overlap. Overlaps with and extends into CDS SCJ1.01. Contains possible membrane spanning hydrophobic domains. gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0152 SCO0153 SCO0153 SCJ1.02c SCJ1.02c 143776 144363 - hypothetical protein SCJ1.02c%2C probable hypothetical protein%2C len: 195 aa%2C similar to Actinosynnema pretiosum auranticum hypothetical 20.0 KD protein TR:O69206 (EMBL:U33059) (190 aa)%2C fasta scores%2C opt: 524 z-score: 529.6 E(): 3.9e-22%3B 43.2%25 identity in 192 aa overlap. Contains a possible N-terminal signal peptide sequence gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0153 SCO0154 SCO0154 SCJ1.03c SCJ1.03c 144704 145366 - hypothetical protein SCJ1.03c%2C unknown%2Clen:220 aa%2C similarity to Synechocystis sp. (strain PCC 6803) hypothetical 24.8 KD protein TR:P73776 (EMBL: D90909)(218 aa)%2C fasta scores opt: 291 z-score: 344.1 E(): 8.3e-12 31.2%25 identity in 170 aa overlap and a weakly similar to Pseudomonas fluorescens SW:TIPB_PSEFL (EMBL%3B U44827) thiol:disulfide interchange protein TipB precursor (cytochrome C biogenesis protein TipB) (178 aa)%2C fasta scores opt: 148 z-score: 181.8 E(): 0.0091 28.7%25 identity in 122 aa overlap. gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0154 SCO0155 SCO0155 SCJ1.04 SCJ1.04 145499 146122 + transcriptional regulator SCJ1.04%2C possible tetR family transcriptional regulatory protein%2C len: 204 aa%2C similarity to several E.coli proteins including uid operon repressor (gus operon repressor) SW:UIDR_ECOLI (EMBL:M14641)( 196 aa)%2C fasta scores opt: 170 z-score: 212.8 E(): 0.00017 25.5%25identity in 184 aa overlap and the hypothetical transcriptional regulator SW:YDHM_ECOLI (EMBL: AE000260)(199 aa)%2C fasta scores opt: 176 z-score: 219.8 E(): 7e-05 27.6%25 identity in 185 aa overlap. In addition to Lactococcus lactis (subsp. lactis) hypothetical protein SW:YPB3_LACLA (EMBL: X60456) (196 aa)%2C fasta scores opt: 245 z-score: 301.6 E(): 1.9e-09 31.9%25 identity in 188 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0155 SCO0156 SCO0156 SCJ1.05c SCJ1.05c 146034 146351 - hypothetical protein SCJ1.05c%2C doubtful CDS%2C len: 125 aa gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0156 SCO0157 SCO0157 SCJ1.06 SCJ1.06 146603 146980 + hypothetical protein SCJ1.06%2C doubtful CDS%2C len: 125 aa gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0157 SCO0158 SCO0158 SCJ1.07 SCJ1.07 146977 148206 + oxidoreductase SCJ1.07%2C probable oxidoreductase%2C len: 409 aa%3B similar to e.g. Synechocystis sp. (strain PCC 6803) TR:P73735 (EMBL:D90909) NADH dehydrogenase (404 aa)%2C fasta scores opt: 358 z-score: 399.1 E(): 7.1e-15 28.9%25 identity in 353 aa overlap and Rhodococcus globerulus TR:Q57031(EMBL:X80041) ferredoxin reductase BPH (412 aa)%2C fasta scores opt:294 z-score: 328.8 E(): 5.9e-11 31.3%25 identity in 358 aa overlap gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0158 SCO0159 SCO0159 SCJ1.08 SCJ1.08 148216 149184 + ECF sigma factor SCJ1.08 ECF sigma factor%2C len: 322 aa%2C similar to many e.g. S. coelicolor TR:CAB44418 (EMBL:AL078610) ECF sigma factor SCH35.09 (223 aa) fasta scores%2C opt: 656 z-score: 777.0 E(): 0 64.6%25 identity in 175 aa overlap and Mycobacterium tuberculosis SIGI protein TR:O50445 (EMBL%3B AL010186)(290 aa)%2C fasta scores opt: 385 z-score: 458.0 E(): 3.7e-18 30.0%25 identity in 290 aa overlap. Contains a Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily). Possible helix-turn-helix motif between 142-163 aa%2C score +4.11 SD gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0159 SCO0160 SCO0160 SCJ1.09c SCJ1.09c 149508 150209 - DNA-binding protein SCJ1.09c%2C possible DNA-binding protein%2C len: 195 aa%2C similarity to Mycobacterium tuberculosis TR:O53625 (EMBL%3B AL021428) hypothetical 16.6 KD protein (152 aa)%2C fasta scores opt: 182 z-score: 220.8 E(): 6.1e-05 34.2%25 identity in 155 aa overlap and Mycobacterium tuberculosis TR:O05803 (EMBL%3B Z95150) hypothetical 12.3 KD protein (110 aa)%2C fasta scores opt: 142 z-score: 177.2 E(): 0.016 34.8%25 identity in 89 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 34..55 (+3.91 SD) gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0160 SCO0161 SCO0161 SCJ1.10c SCJ1.10c 150181 150525 - hypothetical protein SCJ1.10c%2C doubtful CDS%2C len:124 aa. gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0161 SCO0162 SCO0162 SCJ1.11 SCJ1.11 150579 151571 + hypothetical protein SCJ1.11%2C unknown%2C similar to several including: Mycobacterium tuberculosis TR:O53476(EMBL%3B AL021899) hypothetical 36.6 KD protein (331 aa)%2C fasta scores opt: 394 z-score: 468.4 E(): 1e-18 32.2%25 identity in 332 aa overlap and Mycobacterium tuberculosis TR:O05800 (EMBL%3B Z95150) hypothetical 38.5 KD protein (344 aa)%2C fasta scores opt: 345 z-score: 410.5 E(): 1.7e-15 30.2%25 identity in 324 aa overlap. gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0162 SCO0163 SCO0163 SCJ1.12 SCJ1.12 151749 153275 + hypothetical protein SCJ1.12 unkown%2C len: 508 aa%2C similar to Mycobacterium tuberculosis SW:YW13_MYCTU (EMBL%3B Z74025) hypothetical 54.4 KD protein CY39.13 (498 aa)%2Cfasta scores opt: 1192 z-score: 1332.4 E(): 0 43.8%25 identity in 470 aa overlap and Aquifex aeolicus TR:O66641 (EMBL: AE000682) hypothetical 38.3 KD protein (322 aa)%2C fasta scores opt: 550 z-score: 618.7 E(): 4.2e-27 35.5%25 identity in 279 aa overlap. Contains a PS00017 ATP/GTP-binding site motif A (P-loop). gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0163 SCO0164 SCO0164 SCJ1.13 SCJ1.13 153398 155728 + cation-transporting ATPase SCJ1.13%2C cation-transporting ATPase%2C len: 776 aa%2C similar to many including: Mycobacterium tuberculosis SW:CTPG_MYCTU (EMBL:Z74025) probable cation-transporting ATPase G (771 aa)%2C fasta scores opt: 1050 z-score: 1095.0 E(): 0 37.6%25 identity in 588 aa overlap%2C Mycobacterium tuberculosis TR:O66027 (EMBL:U82820)(EMBL metal-transporting ATPase MTA72 (680 aa)%2C fasta scores opt: 1036 z-score: 1081.2 E(): 0 33.8%25 identity in 577 aa overlap and Helicobacter felis SW:COPA_HELFE (EMBL: AJ001932) copper-transporting ATPase (EC 3.6.1.36) (732 aa)%2C fasta scores opt: 904 z-score: 943.3 E(): 0%2C 33.1%25 identity in 547 aa overlap.Contains possible membrane spanning hydrophobic domains%2C a Pfam match to entry PF00122 E1-E2_ATPase%2C E1-E2 ATPases and a PS00154 E1-E2 ATPases phosphorylation site. gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0164 SCO0165 SCO0165 SCJ1.14c SCJ1.14c 155707 156120 - hypothetical protein SCJ1.14c%2C unknown%2C len:137 aa%2C shares a low level of similarity with Aquifex aeolicus TR:O66857 (EMBL:AE000697) hypothetical 14.5 KD protein (130 aa)%2C fasta scores opt:144 z-score: 190.2 E(): 0.003127.2%25 identity in 103 aa overlap. Contains a PS00216 Sugar transport proteins signature 1. gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0165 SCO0166 SCO0166 SCJ1.15 SCJ1.15 156338 157141 + regulator SCJ1.15%2C possible regulator%2C len: 267 aa%2C highly similar to Pseudomonas aeruginosa substrain OT684 TR:P72119 (EMBL:U12891) pyoverdine gene transcriptional regulator PvdS (237 aa)%2C fasta scores opt: 1040 z-score: 1209.8 E(): 0 60.4%25 identity in 235 aa overlap and Mycobacterium tuberculosis TR:O05877 (EMBL%3B Z95121) hypothetical 34.1 KD protein MTCY20B11.07C (295 aa) fasta scores opt: 1189 z-score: 1380.2 E(): 0 65.6%25 identity in 262 aa overlap. gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0166 SCO0167 SCO0167 SCJ1.16c SCJ1.16c 157189 158073 - hypothetical protein SCJ1.16c%2C unknown%2C len: 294 aa%2C similar to many including: Mycobacterium tuberculosis TR:O06189 (EMBL%3B Z95387)hypothetical 31.7 KD protein MTCY1A10.09C (297 aa)%2C fasta scores opt: 407 z-score: 484.5 E(): 1.3e-19 32.7%25 identity in 303 aa overlap and Mycobacterium tuberculosis SW:YW12_MYCTU (EMBL%3B Z74025) hypothetical 30.9 KD protein MTCY39.12 (295 aa)%2C fasta scores opt: 401 z-score: 477.5 E(): 3.1e-19 34.7%25 identity in 294 aa overlap. Also similar to S. coelicolor SCJ1.29c (283 aa)%2C fasta scores opt: 806 z-score: 761.9 E(): 0 46.4%25 identity in 295 aa overlap. Contains a Pfam match to entry PF00582 Usp%2C Universal stress protein family. gene gene154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0167 SCO0168 SCO0168 SCJ1.17 SCJ1.17 158732 159304 + regulator protein SCJ1.17%2C possible regulator%2C len: 190 aa%2C similar to Mycobacterium tuberculosis TR:O69644 (EMBL%3B AL022121) transcriptional regulator MTV025.024 (224 aa)%2C fasta scores opt: 199 z-score: 254.8 E(): 7.8e-07 31.5%25 identity in 124 aa overlap. Contains a Pfam match to entry PF00027 cNMP_binding%2C Cyclic nucleotide-binding domain. gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0168 SCO0169 SCO0169 SCJ1.18 SCJ1.18 159372 160025 + hypothetical protein SCJ1.18%2C conserved hypothetical protein%2C len: 217 aa. Duplication of DNA region complement(17965..18576). Similar to many hypothetical proteins including: Thermotoga maritima TR:AAD36216 (EMBL%3B AE001771) conserved hypothetical protein (215 aa)%2C fasta scores opt: 239 z-score: 287.3 E(): 1.2e-08 29.1%25 identity in 175 aa overlap and S. coelicolor SCJ1.19c (223 aa)%2C fasta scores opt: 711 z-score: 702.0 E(): 7.1e-34 56.7%25 identity in 215 aa overlap.Contains 2xPfam match to entry PF00571 CBS%2C CBS domains. gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0169 SCO0170 SCO0170 SCJ1.19c SCJ1.19c 160356 161027 - hypothetical protein SCJ1.19c%2C conserved hypothetical protein%2C len: 223 aa. Duplication of DNA region 16907..17518. Similar to many hypothetical proteins including: Thermotoga maritima TR:AAD36216 (EMBL%3B AE001771) conserved hypothetical protein (215 aa)%2C fasta scores opt: 204 z-score: 245.5 E(): 2.6e-06 29.3%25 identity in 133 aa overlap and S. coelicolor SCJ1.18 (217 aa)%2C fasta scores opt: 711 z-score: 712.7 E(): 1.8e-34 56.7%25 identity in 215 aa overlap. Contains 2x Pfam match to entry PF00571 CBS%2C CBS domains gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0170 SCO0171 SCO0171 SCJ1.20 SCJ1.20 161237 162553 + nicotinate phosphoribosyltransferase catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0171 SCO0172 SCO0172 SCJ1.21 SCJ1.21 162661 163119 + hypothetical protein SCJ1.21%2C hypothetical protein%2C len: 152 aa. Similar to many hypothetical proteins including: Mycobacterium tuberculosis TR:O53472 (EMBL%3B AL021899) hypothetical 31.5 KD protein MTV018.13C (294 aa)%2C fasta scores opt: 248 z-score: 298.8 E(): 2.8e-09 35.6%25 identity in 160 aa overlap and Methanobacterium thermoautotrophicum TR:O27074 (EMBL%3B AE000872) conserved protein (143 aa)%2C fasta scores opt: 195 z-score: 241.7 E(): 4.2e-06 32.4%25 identity in 142 aa overlap. Contains a Pfam match to entry PF00582 Usp%2C Universal stress protein family. gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0172 SCO0173 SCO0173 SCJ1.22c SCJ1.22c 163235 164017 - hypothetical protein SCJ1.22c%2C unkown%2C len: 260 aa. gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0173 SCO0174 SCO0174 SCJ1.23c SCJ1.23c 164023 164994 - DNA-binding protein SCJ1.23c%2C possible DNA-binding protein%2C len: 323 aa. Similar in parts to many%2C e.g. Mycobacterium tuberculosis TR:O53625 (EMBL%3B AL021428) hypothetical 16.6 KD protein MTV030.24 (152 aa)%2C fasta scores opt: 224 z-score: 258.5 E(): 4.9e-07 34.3%25 identity in 134 aa overlap and Mycobacterium tuberculosis SW:YU07_MYCTU (EMBL%3B Z77163) hypothetical 8.6 KD protein MTCY339.07C (80 aa)%2C fasta scores opt: 182 z-score: 216.4 E(): 0.00011 42.3%25 identity in 71 aa overlap. Also similar to TR:Q9RJ05 (EMBL:AL109962) Streptomyces coelicolor possible DNA-binding protein SCJ1.09c%2C 233 aa%3B fasta scores: opt: 516 Z-score: 566.6 E(): 6.3e-24%3B 37.615%25 identity in 218 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 127..148 (+2.82 SD) gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0174 SCO0175 SCO0175 SCJ1.24c SCJ1.24c 165059 165406 - hypothetical protein SCJ1.24c%2C unknown%2C len: 115 aa. gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0175 SCO0176 SCO0176 SCJ1.25 SCJ1.25 165460 165855 + hypothetical protein SCJ1.25%2C unknown%2C len: 131 aa. gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0176 SCO0177 SCO0177 SCJ1.26 SCJ1.26 166033 166614 + hypothetical protein SCJ1.26%2C possible membrane protein%2C len: 193 aa. Similar to Mycobacterium tuberculosis TR:P71991(EMBL%3B Z81360) hypothetical 22.5 KD protein (210 aa)%2C fasta scores opt: 287 z-score: 333.1 E(): 3.4e-11 35.2%25 identity in 182 aa overlap and S. coelicolor TR:Q9ZBP2 (EMBL%3BAL034492) 50KD proline rich protein (456 aa)%2C fasta scores opt: 338 z-score: 385.2 E(): 4.3e-14 35.6%25 identity in 188 aa overlap. Contains possible membrane-spanning hydrophobic region. gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0177 SCO0178 SCO0178 SCJ1.27 SCJ1.27 166891 167337 + hypothetical protein SCJ1.27%2C unknown%2C len: 148 aa. Weak similarity to Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL%3B Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa)%2C fasta scores opt: 201 z-score: 231.7 E(): 1.5e-05 33.1%25 identity in 136 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL%3B Z95387)hypothetical 31.7 KD protein MTCY1A10.09C (297 aa)%2C fasta scores opt: 199 z-score: 229.8 E(): 1.9e-05 33.3%25 identity in 153 aa overlap. gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0178 SCO0179 SCO0179 SCJ1.28c SCJ1.28c 167444 168514 - zinc-containing dehydrogenase SCJ1.28c%2Cpossible zinc-containing dehydrogenase%2C len: 356 aa. Similar to many including: Thermoanaerobacter brockii SW:ADH_THEBR (EMBL%3B X64841) NADP-dependent alcohol dehydrogenase (EC 1.1.1.2) (352 aa)%2C fasta scores opt: 556 z-score: 601.1 E(): 4e-26 33.7%25 identity in 338 aa overlap and Halobacterium volcanii TR:O34179 (EMBL%3B U95372) dehydrogenase (389 aa)%2C fasta scores opt: 715 z-score: 770.1 E(): 0 37.0%25 identity in 351 aa overlap. Contains a Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and a PS00059 Zinc-containing alcohol dehydrogenases signature gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0179 SCO0180 SCO0180 SCJ1.29c SCJ1.29c 168705 169556 - hypothetical protein SCJ1.29c%2C unknown%2C len: 283 aa. Similar to many including: Mycobacterium tuberculosis TR:O53472 (EMBL%3B AL021899) hypothetical 31.5 KD protein (294 aa)%2C fasta scores opt: 329 z-score: 389.0 E(): 2.6e-14 32.1%25 identity in 293 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL%3B Z95387) hypothetical 31.7 KD protein (297 aa)%2C fasta scores opt: 330 z-score: 390.1 E(): 2.3e-14 31.8%25 identity in 296 aa overlap. Also similar to S. coelicolor SCJ1.16c (294 aa)%2C fasta scores opt: 806 z-score: 748.1 E():0 46.1%25 identity in 295 aa overlap. Contains a Pfam match to entry PF00582 Usp%2C Universal stress protein family gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0180 SCO0181 SCO0181 SCJ1.30c SCJ1.30c 169584 170570 - hypothetical protein SCJ1.30c%2C unknown%2C len: 328 aa. Similar to many including: Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL%3B Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa) fasta scores opt: 382 z-score: 439.2 E(): 4.2e-17 32.6%25 identity in 319 aa overlap and Mycobacterium tuberculosis TR:O53472 (EMBL%3B AL021899) hypothetical 31.5 KD protein (294 aa)%2C fasta scores opt: 382 z-score: 439.2 E(): 4.2e-17 32.6%25 identity in 319 aa overlap. Contains a Pfam match to entry PF00582 Usp%2C Universal stress protein family. gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0181 SCO0182 SCO0182 SCJ1.31c SCJ1.31c 170656 170880 - hypothetical protein SCJ1.31c%2C doubtful CDS%2C len: 74 aa. Contains a TTA/leucine codon%2C possible target for bldA regulation. gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0182 SCO0183 SCO0183 SCJ1.32 SCJ1.32 170911 172158 + deoxiribopirymidine photolyase SCJ1.32%2C unknown%2Clen: 415 aa. Likely to have arisen as a result of a duplication of SCF43A.31/32%2C followed by a deletion event generating a possible CDS with the 5' coding sequence of SCF43A.31 and the 3' coding sequence of SCF43A.32. Similarity scores are as follows: to Streptomyces coelicolor TR:CAB48918 (EMBL%3B AL096837) oxidoreductase SCF43A.31 (520 aa)%2C fasta scores opt: 1191 z-score: 1365.3 E(): 0 64.2%25 identity in 307 aa overlap and to Streptomyces coelicolor TR:CAB48919(EMBL%3B AL096837) deoxyribodipyrimidine photolyase SCF43A.32 (458 aa)%2C opt: 909 z-score: 1043.2 E(): 0 45.7%25 identity in 418 aa overlap. Contains a PS00394 DNA photolyases class 1 signature 1 and a PS00691 DNA photolyases class 1 signature 2. gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0183 SCO0184 SCO0184 SCJ1.33 SCJ1.33 172170 173984 + hypothetical protein SCJ1.33 unknown%2C len: 604 aa. Highly similar to Synechocystis sp. (strain PCC6803) TR:P74080 (EMBL%3BD90912) hypothetical 58.1 KD protein (504 aa)%2C fasta scores opt: 931 z-score: 996.4 E(): 0 38.8%25 identity in 479 aa overlap and Methanobacterium thermoautotrophicum TR:O27804 (EMBL%3BAE000932) conserved protein MTH1776 (491 aa)%2C fasta scores opt: 572 z-score: 613.5 E(): 8.1e-27 31.7%25 identity in 483 aa overlap. Also shares a low level of similarity with Streptomyces coelicolor TR:CAB48919 (EMBL%3BAL096837) deoxyribodipyrimidine photolyase SCF43A.32 (458 aa)%2C fasta scores opt: 176 z-score: 191.4 E(): 0.0026 31.1%25 identity in 219 aa overlap. gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0184 SCO0185 SCO0185 crtB crtB 173768 174946 + geranylgeranyl pyrophosphate synthase SCJ1.34%2C crtB%2C possible geranylgeranyl pyrophosphate synthase%2C len: 392 aa. Shares a high level of similarity with Streptomyces griseus TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase (425 aa)%2C fasta scores: opt: 964 z-score: 1076.9 E(): 0 48.0%25 identity in 381 aa overlap and Mycobacterium tuberculosis TR:O53507 (EMBL:AL021957) geranylgeranyl pyrophosphate synthase (352 aa)%2C fasta scores opt: 742 z-score: 831.2 E(): 0 43.0%25 identity in 328 aa overlap. Contains a PS00723 Polyprenyl synthetases signature 1 gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0185 SCO0186 SCO0186 crtE crtE 174943 176514 + phytoene dehydrogenase SCJ1.35%2C crtE%2C probable phytoene dehydrogenase (phytoene desaturase) (hypothetical protein)%2C len: 523 aa. High level of similarity to Streptomyces griseus SW:CRTI_STRGR (EMBL%3B L37405) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (507 aa)%2C fasta scores opt: 2459 z-score: 2615.3 E(): 0%3B 74.5%25 identity in 501 aa overlap and Streptomyces setonii SW:CRTI_STRSE (EMBL%3B D55723) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (508 aa)%2C fasta scores opt: 2455 z-score: 2611.0 E(): 0%3B 74.3%25 identity in 498 aa overlap. Contains a PS00982 Bacterial-type phytoene dehydrogenase signature gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0186 SCO0187 SCO0187 crtI crtI 176501 177496 + phytoene synthase SCJ1.36%2C crtI%2C probable phytoene synthase%2C len: 331 aa. Shares a high level of similarity with Streptomyces griseus SW:CRTB_STRGR (EMBL%3B L37405) phytoene synthase (342 aa)%2C fasta scores opt: 1388 z-score: 1657.5 E(): 0 67.6%25 identity in 343 aa overlap and Mycobacterium marinum TR: O05423 (EMBL%3B U92075) phytoene synthase (319 aa)%2C fasta scores opt: 996 z-score: 1191.5 E():0 52.2%25 identity in 316 aa overlap. Contains a PS01045 Squalene and phytoene synthases signature 2 and a Pfam match to entry PF00494 SQS_PSY%2C Squalene and phytoene synthases gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0187 SCO0188 SCO0188 crtV crtV 177493 178503 + methylesterase SCJ1.37%2C crtV%2C probable methylesterase%2C len: 336 aa. Highly similar to Streptomyces griseus TR:P72448 (EMBL%3B X95596) methylesterase (338 aa)%2C fasta scores opt: 1315 z-score: 1538.7 E(): 0 60.5%25 identity in 337 aa overlap gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0188 SCO0189 SCO0189 crtU crtU 178519 180087 - dehydrogenase SCJ1.38c%2C crtU%2C probable dehydrogenase%2C a partial CDS%2C len: >336 aa. Highly similar to Streptomyces griseus TR:P72449 (EMBL:X95596) dehydrogenase (517 aa)%2C fasta scores opt: 1277 z-score: 1459.8 E():0 69.0%25 identity in 281 aa overlap and Synechocystis sp SW:CRTI_SYNY3 (EMBL%3B X62574) phytoene dehydrogenase (427 aa)%2C fasta scores opt: 133 z-score: 155.8 E():0.25 24.6%25 identity in 260 aa overlap.~SCJ12.01c%2C crtU%2C probable dehydrogenase%2C partial CDS%2C len: >278 aa. Highly similar to Streptomyces griseus TR:P72449 (EMBL:X95596) dehydrogenase (517 aa)%2C fasta scores opt: 1311 z-score: 1471.3 E(): 0 74.0%25 identity in 269 aa overlap and Synechocystis sp. (strain PCC 6803) SW:CRTI_SYNY3 (EMBL:X62574) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (427 aa)%2C fasta scores opt: 219 z-score: 250.2 E(): 1.4e-06 27.6%25 identity in 254 aa overlap. gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0189 SCO0190 SCO0190 crtT crtT 180084 180824 - methyltransferase SCJ12.02c%2C crtT%2C probable methyltransferase%2C len: 246 aa. Shares a high level of sequence similarity with Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa)%2C fasta scores opt: 984 z-score: 1164.2 E(): 0 65.0%25 identity in 234 aa overlap. Contains a Pfam match to entry PF01209 Ubie_methyltran%2C ubiE/COQ5 methyltransferase family gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0190 SCO0191 SCO0191 crtY crtY 180821 182038 - lycopene cyclase SCJ12.03c%2C crtY%2C probable lycopene cyclase%2C len: 405 aa. Highly similar to Streptomyces griseus TR:P72451 (EMBL:X95596) lycopene cyclase (418 aa)%2C fasta scores opt: 1426 z-score: 1602.7 E(): 0 56.3%25 identity in 396 aa overlap gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0191 SCO0192 SCO0192 SCJ12.04c SCJ12.04c 182309 183559 - oxidoreductase SCJ12.04c%2C possible oxidoreductase%2C len: 416 aa. Similar to many protoporphyrinogen oxidases including: Propionibacterium freudenreichii shermanii SW:PPOX_PROFR (EMBL:D85417) HemY (527 aa)%2C fasta scores opt: 228 z-score: 249.0 E(): 1.6e-06 26.8%25 identity in 504 aa overlap and Bacillus subtilis SW:PPOX_BACSU (EMBL%3B M97208) HemY (470 aa)%2C fasta scores opt: 209 z-score: 229.3 E(): 2.1e-05 25.7%25 identity in 311 aa overlap. Contains a Pfam match to entry PF01593 Amino_oxidase gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0192 SCO0193 SCO0193 SCJ12.05c SCJ12.05c 183793 184797 - DNA-binding regulator SCJ12.05c%2C possible DNA-binding regulator%2C len:334 aa. Some similarity to Myxococcus xanthus TR:Q50900 (EMBL:Z21955) regulatory protein (299 aa)%2C fasta scores opt: 121 z-score: 141.6 E(): 1.6 32.4%25 identity in 281 aa overlap and Myxococcus xanthus TR:Q50899 (EMBL:Z21955) regulatory protein (288 aa)%2C fasta scores opt: 118 z-score: 138.5 E() 2.4 26.9%25 identity in 279 aa overlap. Contains a possible helix-turn-helix motif between aa's 23..44. gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0193 SCO0194 SCO0194 SCJ12.06 SCJ12.06 184958 185566 + sigma factor SCJ12.06%2C possible sigma factor%2C len: 202 aa. Similar to many including: Rhodobacter sphaeroide TR:O33546 (EMBL%3B U11283) RpoE homologue (168 aa)%2C fasta scores opt: 291 z-score: 373.4 E(): 1.9e-13 35.4%25 identity in 161 aa overlap and Streptomyces coelicolor TR:O54163 (EMBL%3B AL021411) sigma factor SC7H1.04 (200 aa)%2C fasta scores opt: 255 z-score: 327.4 E(): 7.1e-11 33.7%25 identity in 184 aa overlap. Contains a PS01063 Sigma-70 factors ECF subfamily signature and a Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily). Contains a possible helix-turn-helix motif between aa's 162..183. gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0194 SCO0195 SCO0195 SCJ12.07 SCJ12.07 185675 186361 + lipoprotein SCJ12.07%2C possible lipoprotein%2C len: 228 aa. Contains an N-terminal signal sequence and a PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0195 SCO0196 SCO0196 SCJ12.08 SCJ12.08 186483 186887 + hypothetical protein SCJ12.08%2C unknown%2C len:134 aa. Shares a low level of similarity with Mycobacterium tuberculosis TR:O53597 (EMBL%3B AL021426) hypothetical 24.0 KD protein MTV028.10C (224 aa)%2C fasta scores opt: 119 z-score: 159.2 E(): 0.1 32.8%25 identity in 116 aa overlap. gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0196 SCO0197 SCO0197 SCJ12.09c SCJ12.09c 187019 187459 - hypothetical protein SCJ12.09c%2C hypothetical protein%2C len: 146 aa. Some similarity to Mycobacterium tuberculosis TR:O53625 (EMBL%3B AL021428) hypothetical 16.6 KD protein (152 aa)%2C fasta scores opt: 291 z-score: 377.8 E(): 1.1e-13 42.9%25 identity in 133 aa overlap. Also similar to TR:Q9RI34 (EMBL:AL109989) S. coelicolor SCJ12.26 (137 aa)%2C fasta scores: opt: 524 z-score: 568.0 E(): 2.2e-26 62.2%25 identity in 135 aa overlap gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0197 SCO0198 SCO0198 SCJ12.10c SCJ12.10c 187992 188858 - hypothetical protein SCJ12.10c%2C unknown%2C len: 288 aa. Similar to several hypothetical proteins including: Mycobacterium tuberculosis SW:YW12_MYCTU (EMBL%3B Z74025) hypothetical 30.9 KD protein MTCY39.12 (295 aa)%2C fasta scores opt: 363 z-score: 441.0 E(): 3.3e-17 32.3%25 identity in 288 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL%3B Z95387) hypothetical 31.7 KD protein MTCY1A10.09C (297 aa)%2C fasta scores opt: 336 z-score: 408.6 E(): 2.1e-15 29.3%25 identity in 294 aa overlap. Also highly similar to S. coelicolor hypothetical proteins (AL109962) SCJ1.29c (283 aa)%2C fasta scores opt: 1161 z-score: 1097.2 E(): 0 63.5%25 identity in 288 aa overlap and SCJ1.16c (294 aa)%2C fasta scores opt:892 z-score: 844.7 E():0 50.3%25 identity in 296 aa overlap gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0198 SCO0199 SCO0199 SCJ12.11c SCJ12.11c 188864 189886 - alcohol dehydrogenase SCJ12.11c%2C probable alcohol dehydrogenase%2C len: 340 aa. Highly similar to many e.g. Bacillus stearothermophilus SW:ADH3_BACST (EMBL%3B Z27089) alcohol dehydrogenase (EC 1.1.1.1) (ADH-HT) (339 aa)%2C fasta scores opt: 1281 z-score: 1383.7 E(): 0 55.2%25 identity in 337 aa overlap. Contains a PS00059 Zinc-containing alcohol dehydrogenases signature and a Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0199 SCO0200 SCO0200 SCJ12.12c SCJ12.12c 189925 190830 - hypothetical protein SCJ12.12c%2C unknown%2C len: 301 aa. Similar to several hypothetical proteins including: Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL%3B Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa)%2C fasta scores opt: 380 z-score: 447.3 E(): 1.5e-17 33.5%25 identity in 316 aa overlap and S. coelicolor (EMBL%3BAL109962) SCJ1.30c (328 aa)fasta scores opt: 1274 z-score: 1163.7 E():0 65.3%25 identity in 300 aa overlap. Contains 2x Pfam match to entry PF00582 Usp%2C Universal stress protein family. gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0200 SCO0201 SCO0201 SCJ12.13c SCJ12.13c 190983 191654 - hypothetical protein SCJ12.13c%2C possible integral membrane protein%2C len: 223 aa. Contains potential membrane spanning hydrophobic domains. gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0201 SCO0202 SCO0202 SCJ12.14 SCJ12.14 191919 192848 + hypothetical protein SCJ12.14%2C unknown%2C len: 309 aa. Similar to Mycobacterium tuberculosis TR:P95195 (EMBL%3B Z83867) hypothetical 36.0 KD protein MTCY03A2.27C (332 aa)%2C fasta scores opt: 331 z-score: 377.3 E(): 1.2e-13 28.1%25 identity in 310 aa overlap and S. coelicolor SCJ12.27c (335 aa)%2C fasta scores opt: 780 z-score: 721.8 E(): 5.9e-35 45.8%25 identity in 308 aa overlap gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0202 SCO0203 SCO0203 SCJ12.15c SCJ12.15c 192880 194637 - two-component sensor SCJ12.15c%2C probable two-component sensor. len: 585 aa. Similarity to Streptomyces coelicolor TR:Q9ZBY4 (EMBL%3B AL034355) two component sensor SCD78.15 (560 aa)%2C fasta scores opt: 1439 z-score: 1571.0 E(): 0 44.7%25 identity in 553 aa overlap. Also some similarity to Pseudomonas aeruginosa TR:O54040 (EMBL%3B Y15252) nitrate/nitrite sensory protein NarX (622 aa)%2C fasta scores opt: 315 z-score: 344.5 E(): 7.9e-1 29.0%25 identity in 297 aa overlap. Contains 2x Pfam match to entry PF01590 GAF and potential membrane spanning hydrophobic domains. Probable coiled-coil from 17 to 48 (32 residues). gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0203 SCO0204 SCO0204 SCJ12.16c SCJ12.16c 194760 195461 - LuxR family transcriptional regulator SCJ12.16c%2C probable LuxR family transcriptional regulator%2C len: 233 aa. Highly similar to many including: several Streptomyces coelicolor two-component response regulators such as SW:CAB46941 (EMBL%3B AL096822) response regulator SCGD3.19 (218 aa)%2C fasta scores opt: 865 z-score: 987.7 E(): 0 64.7%25 identity in 215 aa overlap. In addition to Pseudomonas aeruginosa TR:O54039 (EMBL%3B Y15252) nitrate/nitrite regulatory protein NarL (216 aa)%2C fasta scores opt: 458 z-score: 528.5 E(): 4.4e-22 38.6%25 identity in 210 aa overlap. Contains a Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and a PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains a possible helix-turn-helix motif between aa's 182..203. gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0204 SCO0205 SCO0205 SCJ12.17c SCJ12.17c 195554 196280 - gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0205 SCO0206 SCO0206 SCJ12.18c SCJ12.18c 196306 196443 - gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0206 SCO0207 SCO0207 SCJ12.19c SCJ12.19c 196386 196991 - hypothetical protein SCJ12.19c%2C unknown%2C len: 201 aa. Weakly similar to many hypotheticals e.g. Thermus aquaticus SW:YQA3_THEAQ (EMBL%3B D87664) hypothetical 14.6 KD protein in QAH/OAS sulfhydrylase 3'region (137 aa)%2C fasta scores opt: 172 z-score: 213.8 E(): 0.00015 35.9%25 identity in 142 aa overlap. Also similar to the N-terminal region of TR:Q9RI46 (EMBL:AL109989) Streptomyces coelicolor hypothetical protein SCJ12.12c%2C 301 aa%3B fasta scores: opt: 466 Z-score: 532.5 E(): 5e-22%3B 42.500%25 identity in 200 aa overlap gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0207 SCO0208 SCO0208 SCJ12.20 SCJ12.20 197221 199917 + pyruvate phosphate dikinase catalyzes the formation of phosphoenolpyruvate from pyruvate gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0208 SCO0209 SCO0209 SCJ12.21 SCJ12.21 200024 200428 + hypothetical protein SCJ12.21%2C unknown%2C len: 134 aa. gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0209 SCO0210 SCO0210 SCJ12.22 SCJ12.22 200728 201369 + hypothetical protein SCJ12.22%2C hypothetical protein%2C len: 213 aa. Similar in parts to several hypotheticals e.g. Methanopyrus kandleri SW:IMDH_METKA (EMBL%3B U31567) OrfX (fragment) (172 aa)%2C fasta scores opt: 251 z-score: 300.4 E(): 2.3e-09 34.5%25 identity in 116 aa overlap. Also similar to S. coelicolor conserved hypothetical proteins (AL109962) SCJ1.19c (223 aa)%2C fasta scores opt: 411 z-score: 396.5 E(): 7.9e-17 47.3%25 identity in 201 aa overlap and SCJ1.18 (217 aa)%2C fasta scores opt: 371 z-score: 359.1 E(): 9.5e-15 44.4%25 identity in 196 aa overlap. Contains 2x Pfam matches to entry PF00571 CBS%2C CBS domains. gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0210 SCO0211 SCO0211 SCJ12.23 SCJ12.23 201374 202090 + hypothetical protein SCJ12.23%2C unknown%2C len: 238 aa. Weakly similar%2C in parts%2C to many two component sensor kinases e.g. E. coli SW:NARQ_ECOLI (EMBL%3B M94724) nitrate/nitrite sensor protein NarQ (EC 2.7.3.-) (566 aa)%2C fasta scores opt: 424 z-score: 475.7 E(): 3.9e-19 39.5%25 identity in 238 aa overlap and Streptomyces coelicolor TR:Q9ZBY4 (EMBL%3B AL034355) two component sensor SCD78.15 (560 aa)%2C fasta scores opt: 424 z-score: 475.7 E(): 3.9e-19 39.5%25 identity in 238 aa overlap gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0211 SCO0212 SCO0212 SCJ12.24c SCJ12.24c 202370 202843 - hypothetical protein SCJ12.24c%2C unknown%2C len: 157 aa. gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0212 SCO0213 SCO0213 SCJ12.25c SCJ12.25c 202863 204101 - nitrate/nitrite transporter SCJ12.25c%2C possible nitrate/nitrite transporter%2C len: 412 aa. Similar to Bacillus subtilis SW:NARK_BACSU (EMBL%3B Z49884) nitrite extrusion protein (395 aa)%2C fasta scores opt: 834 z-score: 877.9 E():0 36.8%25 identity in 378 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0213 SCO0214 SCO0214 SCJ12.26 SCJ12.26 204387 204800 + hypothetical protein SCJ12.26%2C hypothetical protein%2C len: 137 aa. Some similarity to several hypotheticals e.g. Mycobacterium tuberculosis TR:O53625 (EMBL%3B AL021428) hypothetical 16.6 KD protein (152 aa)%2C fasta scores opt: 291 z-score: 372.0 E(): 2.3e-13 46.5%25 identity in 129 aa overlap. Also similar to TR:Q9RI49 (EMBL:AL109989) S. coelicolor SCJ12.09c (146 aa)%2C fasta scores opt: 524 z-score: 550.7 E(): 2e-25 62.2%25 identity in 135 aa overlap gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0214 SCO0215 SCO0215 SCJ12.27c SCJ12.27c 204881 205888 - hypothetical protein SCJ12.27c%2C unknown%2C len: 335 aa. Similar to several hypotheticals e.g. Mycobacterium tuberculosis TR:P95195 (EMBL%3B Z83867) hypothetical 36.0 KD protein (332 aa)%2C fasta scores opt: 441 z-score: 491.9 E(): 4.9e-20 35.7%25 identity in 319 aa overlap and S. coelicolor (AL109962) hypothetical protein SCJ1.11 (330 aa)%2C fasta scores opt: 816 z-score: 796.1 E():0 43.0%25 identity in 321 aa overlap and SCJ12.14 (309 aa)%2C fasta scores opt: 780 z-score: 755.6 E(): 0 45.8%25 identity in 308 aa overlap. gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0215 SCO0216 SCO0216 narG2 narG2 206480 210181 + nitrate reductase subunit alpha NarG2 SCJ12.28%2C narG2%2C probable nitrate reductase alpha chain%2C len: 1233 aa. Highly similar to Streptomyces coelicolor TR:O86717 (EMBL%3B AL031515) nitrate reductase alpha chain NarG SC5C7.20c (1231 aa)%2C fasta scores: opt: 5792 z-score: 6544.7 E(): 0 67.6%25 identity in 1230 aa overlap and Bacillus subtilis SW:NARG_BACSU (EMBL%3B Z49884) nitrate reductase alpha chain (EC 1.7.99.4) NarG (1228 aa)%2C fasta scores: opt: 4331 z-score: 4891.8 E(): 0 52.9%25 identity in 1201 aa overlap. Contains a PS00551 Prokaryotic molybdopterin oxidoreductases signature 1%2C a Pfam match to entry PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases and a Pfam match to entry PF01568 Molydop_binding%2C Prokaryotic molybdopterin oxidoreductases. gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0216 SCO0217 SCO0217 narH2 narH2 210183 211751 + nitrate reductase subunit beta NarH2 SCJ12.29%2C narH2%2C probable nitrate reductase beta chain%2C len: 522 aa. Highly similar to many e.g. Streptomyces coelicolor TR:O86716 (EMBL%3B AL031515) nitrate reductase beta chain NarH SC5C7.19c (531 aa)%2C fasta scores: opt: 2348 z-score: 2413.0 E(): opt: 2348 z-score: 2413.0 E(): 0 65.3%25 identity in 496 aa overlap and Bacillus subtilis SW:NARH_BACSU (EMBL%3B Z49884) nitrate reductase beta chain (EC 1.7.99.4) NarH (487 aa)%2C fasta scores: opt: 2081 z-score: 2139.7 E(): 0 57.1%25 identity in 485 aa overlap. Contains a PS00190 Cytochrome c family heme-binding site signature%2C a Pfam match to entry PF00037 fer4%2C 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and a Pfam match to entry PF00037 fer4%2C 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains. gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0217 SCO0218 SCO0218 narJ2 narJ2 211748 212551 + nitrate reductase subunit delta NarJ2 SCJ12.30%2C narJ2%2C probable nitrate reductase delta chain%2C len: 267 aa. Similar to many e.g. Bacillus subtilis SW:NARJ_BACSU (EMBL:Z49884) nitrate reductase delta chain NarJ (EC 1.7.99.4) SC5C7.18c (184 aa)%2C fasta scores: opt: 287 z-score: 314.9 E(): 3.5e-10 32.9%25 identity in 164 aa overlap and Streptomyces coelicolor TR:O86715 (EMBL:AL031515) nitrate reductase delta chain SC5C7.18c (164 aa)%2C fasta scores: opt: 309 z-score: 338.8 E(): 1.6e-11 40.1%25 identity in 172 aa overlap. gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0218 SCO0219 SCO0219 narI2 narI2 212551 213321 + nitrate reductase subunit delta NarI2 SCJ12.31%2C narI2%2C possible nitrate reductase gamma chain%2C len: 256 aa. Similar to many including: Streptomyces coelicolor TR:O86714 (EMBL:AL031515) nitrate reductase gamma chain NarI SC5C7.17c (240 aa)%2C fasta scores: opt: 755 z-score: 891.5 E(): 0 46.8%25 identity in 235 aa overlap and Bacillus subtilis SW:NARI_BACSU (EMBL:Z49884) nitrate reductase gamma chain (EC 1.7.99.4) (223 aa)%2C fasta scores: opt: 668 z-score: 790.4 E(): 0 43.6%25 identity in 225 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0219 SCO0220 SCO0220 SCJ12.32 SCJ12.32 213427 213870 + hypothetical protein SCJ12.32%2C unknown%2C len: 147 aa. gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0220 SCO0221 SCO0221 SCJ12.33c SCJ12.33c 213895 214553 - gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0221 SCO0222 SCO0222 SCJ9A.01 SCJ9A.01 214913 215446 + acetyltransferase SCJ9A.01%2C possible acetyltransferase%2C len: 177 aa%3B similar to many e.g. TR:Q53796 (EMBL:L26955) bleomycin acetyltransferase from Streptomyces verticillus (301 aa) fasta scores%3B opt: 150%2C z-score: 190.2%2C E(): 0.0031%2C (30.8%25 identity in 169 aa overlap). Also similar to TR:CAB44535 (EMBL:AL078618) acetyltransferase from Streptomyces coelicolor (187 aa) fasta scores%3B opt: 215%2C z-score: 271.9%2C E(): 8.8e-08%2C (34.2%25 identity in 146 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0222 SCO0223 SCO0223 SCJ9A.02 SCJ9A.02 215443 215559 + hypothetical protein SCJ9A.02%2C improbable CDS%2C function unknown%2C len: 38aa%3B predicted by Hidden Markov Model and amino acid usage. gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0223 SCO0224 SCO0224 SCJ9A.03c SCJ9A.03c 215807 216844 - hypothetical protein SCJ9A.03c%2C unknown%2C len: 345aa%3B similar to TR:CAB45045 (EMBL:AL078635) hypothetical protein from Amycolatopsis orientalis (353 aa) fasta scores%3B opt: 1018%2C z-score: 1095.3%2C E(): 0%2C (47.3%25 identity in 355 aa overlap). gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0224 SCO0225 SCO0225 SCJ9A.04c SCJ9A.04c 216834 217268 - hypothetical protein SCJ9A.04c%2C unknown%2C len: 144aa%3B predicted by amino acid usage. gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0225 SCO0226 SCO0226 SCJ9A.05c SCJ9A.05c 217315 218019 - hypothetical protein SCJ9A.05c%2C possible membrane protein%2C len: 234aa%3B contains possible peripheral membrane hydrophobic region. gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0226 SCO0227 SCO0227 SCJ9A.06c SCJ9A.06c 218418 218780 - hypothetical protein SCJ9A.06c%2C unknown%2C len: 120aa%3B predicted by GC Frameplot and amino acid usage. gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0227 SCO0228 SCO0228 SCJ9A.07 SCJ9A.07 218973 219059 + hypothetical protein SCJ9A.07%2C unknown%2C len: 28aa%3B predicted by GC Frameplot and amino acid usage. gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0228 SCO0229 SCO0229 SCJ9A.08 SCJ9A.08 219302 220150 + short chain dehydrogenase SCJ9A.08%2C probable oxidoreductase (hypothetical protein)%2C len: 282 aa%3B similar to many e.g. TR:CAB51136 (EMBL:Y18817) oxidoreductase of short chain from Streptomyces coelicolor (276 aa) fasta scores%3B opt: 615%2C z-score: 697.7%2C E(): 1.7e-31%2C (40.9%25 identity in 274 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0229 SCO0230 SCO0230 SCJ9A.09 SCJ9A.09 220150 220764 + TetR family transcriptional regulator SCJ9A.09%2C possible tetR-family transcriptional regulator%2C len: 204 aa%3B similar to many proposed regulators and hypothetical proteins e.g. TR:CAB46789 (EMBL:AL096811) tetR transcriptional regulator from Streptomyces coelicolor (251 aa) fasta scores%3B opt: 194%2C z-score: 252.1%2C E(): 1.1e-06%2C (35.3%25 identity in 102 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and Prosite match to PS01081 Bacterial regulatory proteins%2C tetR family signature. Also contains possible helix-turn-helix motif (+3.50 SD) 41-62 aa gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0230 SCO0231 SCO0231 SCJ9A.10c SCJ9A.10c 221092 221247 - hypothetical protein SCJ9A.10c%2C small hydrophobic protein%2C function unknown%2C len: 51 aa%3B predicted by GC Frameplot%2C Hidden Markov Model and amino acid usage. Contains possible hydrophobic membrane spanning regions gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0231 SCO0232 SCO0232 SCJ9A.11c SCJ9A.11c 221414 221599 - hypothetical protein SCJ9A.11c%2C unknown%2C len: 61aa%3B predicted by GC Frameplot%2C Hidden Markov Model and amino acid usage. Similar to a region of several aldolases eg. TR:AAB40121 (EMBL:U70664) from Haloferax sp. (215 aa) fasta scores%3B opt: 140%2C z-score: 198.7%2C E(): 0.0011%2C (49.0%25 identity in 51 aa overlap). gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0232 SCO0233 SCO0233 SCJ9A.12c SCJ9A.12c 221699 222538 - DNA-binding protein SCJ9A.12c%2C possible DNA-binding protein%2C len: 279 aa%3B N-terminal similar to TR:O86721 (EMBL:AL031515) hypothetical protein from Streptomyces coelicolor (272 aa) fasta scores%3B opt: 135%2C z-score: 165.1%2C E(): 0.079%2C (29.3%25 identity in 150 aa overlap). Contains possible helix-turn-helix motif (+3.31 SD) 37-58 aa gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0233 SCO0234 SCO0234 SCJ9A.13 SCJ9A.13 222827 223288 + oxidoreductase SCJ9A.13%2C probable oxidoreductase%2C len: 153aa%3B similar to many eg. SW:DHG_BACME glucose dehydrogenase from Bacillus megaterium (261 aa) fasta scores%3B opt: 252%2C z-score: 277.8%2C E(): 4.1e-08%2C (44.0%25 identity in 100 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0234 SCO0235 SCO0235 SCJ9A.14 SCJ9A.14 223294 224232 + short chain dehydrogenase SCJ9A.14%2C possible oxidoreductase%2C len: 312 aa%3B similar to many proposed oxidoreductases e.g. TR:O53537 (EMBL:AL021925) oxidoreductase from Mycobacterium tuberculosis (317 aa) fasta scores%3B opt: 988%2C z-score: 1030.4%2C E(): 0%2C (52.6%25 identity in 304 aa overlap). Also similar to SCJ9A.19c five CDSs downstream (311 aa) fasta scores%3B opt: 433%2C z-score: 409.8%2C E(): 1.4e-17%2C (38.0%25 identity in 300 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0235 SCO0236 SCO0236 SCJ9A.15c SCJ9A.15c 224404 225276 - DNA-binding protein SCJ9A.15c%2C possible DNA-binding protein%2C len: 290 aa%3B prediction based on GC Frameplot%2C Hidden Markov Model and amino acid usage. Similar to TR:CAC44562 (EMBL:AL596144) Streptomyces coelicolor DNA-binding protein SCBAC12C8.07c%2C 284 aa%3B fasta scores: opt: 636 Z-score: 730.2 E(): 4.9e-33%3B 43.060%25 identity in 281 aa overlap. Contains possible helix-turn-helix motif (+3.31 SD) residues 39-60 gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0236 SCO0237 SCO0237 SCJ9A.16 SCJ9A.16 225476 226237 + oxidoreductase SCJ9A.16%2C possible oxidoreductase%2C len: 253 aa%3B similar to many proposed oxidoreductases e.g. SW:DLTE_BACSU from Bacillus subtilis (252 aa) fasta scores%3B opt: 368%2C z-score: 429.4%2C E(): 1.5e-16%2C (33.2%25 identity in 205 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0237 SCO0238 SCO0238 SCJ9A.17 SCJ9A.17 226481 227008 + hypothetical protein SCJ9A.17%2C hypothetical protein%2C len: 175 aa%3B similar to TR:Q9RI91 (EMBL:AL109949) Streptomyces coelicolor hypothetical protein SCJ11.13%2C 152 aa%3B fasta scores: opt: 683 Z-score: 798.0 E(): 8.1e-37%3B 68.421%25 identity in 152 aa overlap gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0238 SCO0239 SCO0239 SCJ9A.18c SCJ9A.18c 227081 228154 - hypothetical protein SCJ9A.18c%2C unknown%2C len: 357aa gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0239 SCO0240 SCO0240 SCJ9A.19c SCJ9A.19c 228714 229649 - oxidoreductase SCJ9A.19c%2C possible oxidoreductase%2C len: 311aa%3B similar to many proposed oxidoreductases eg. TR:O53613 (EMBL:AL021428) oxidoreductase from Mycobacterium tuberculosis (303 aa) fasta scores%3B opt: 746%2C z-score: 814.7%2C E(): 0%2C (43.0%25 identity in 305 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0240 SCO0241 SCO0241 SCJ9A.20 SCJ9A.20 229995 230669 + transcriptional regulator SCJ9A.20%2C possible transcriptional regulator%2C len: 224aa%3B similar to many proposed transcriptional regulators eg. TR:O53737 (EMBL:AL021932) transcriptional regulator from Streptomyces coelicolor (236 aa) fasta scores%3B opt: 308%2C z-score: 371.4%2C E(): 2.5e-13%2C (30.3%25 identity in 221 aa overlap). Contains possible helix-turn-helix motif (+3.83 SD) 37-58 aa gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0241 SCO0242 SCO0242 SCJ9A.21 SCJ9A.21 231022 231465 + hypothetical protein SCJ9A.21%2C unknown%2C len: 147aa%3B similar to TR:Q98JA0 (EMBL:AP002998) MLR2034 protein from Rhizobium loti (Mesorhizobium loti) (145 aa) fasta scores%3B opt: 334%2C Z-score: 400.1%2C E(): 1.2e-14%2C 37.324%25 identity (37.324%25 ungapped) in 142 aa overlap. Weak similarity to SW:YAER_ECOLI hypothetical protein from Escherichia coli (129 aa) fasta scores%3B opt: 105%2C z-score: 139.5%2C E(): 2.1%2C (25.0%25 identity in 148 aa overlap). gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0242 SCO0243 SCO0243 SCJ9A.22 SCJ9A.22 231475 231654 + hypothetical protein SCJ9A.22%2C unknown%2C len: 59aa gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0243 SCO0244 SCO0244 SCJ9A.23 SCJ9A.23 232508 233518 + hypothetical protein SCJ9A.23%2C hypothetical protein%2C len: 336 aa%3B similar to TR:O88063 (EMBL:AL031541) hypothetical protein from Streptomyces coelicolor (322 aa) fasta scores%3B opt: 852%2C z-score: 891.5%2C E(): 0%2C (51.9%25 identity in 320 aa overlap) gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0244 SCO0245 SCO0245 SCJ9A.24c SCJ9A.24c 233854 234873 - hypothetical protein SCJ9A.24c%2C possible integral membrane protein%2C len: 339aa%3B similar to many hypothetical proteins eg. SW:Y0D3_MYCTU from Mycobacterium tuberculosis (345 aa) fasta scores%3B opt: 598%2C z-score: 676.4%2C E(): 2.6e-30%2C (34.2%25 identity in 333 aa overlap). Contains two Pfam matches to entry PF00571 CBS%2C CBS domain and a Pfam match to entry PF01595 DUF21. Also contains possible membrane spanning hydrophobic regions in the N-terminal region. gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0245 SCO0246 SCO0246 SCJ9A.25c SCJ9A.25c 234870 236207 - hypothetical protein SCJ9A.25c%2C possible integral membrane protein%2C len: 445aa%3B similar to many hypothetical proteins eg. SW:Y0D2_MYCTU from Mycobacterium tuberculosis (455 aa) fasta scores%3B opt: 925%2C z-score: 997.3%2C E(): 0%2C (39.4%25 identity in 411 aa overlap). Contains two Pfam matches to entry PF00571 CBS%2C CBS domain and a Pfam match to entry PF01595 DUF21. Also contains possible membrane spanning hydrophobic regions in the N-terminal region. gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0246 SCO0247 SCO0247 SCJ9A.26 SCJ9A.26 236782 237807 + hypothetical protein SCJ9A.26%2C unknown%2C possibly membrane associated%2C len: 341aa%3B similar to TR:P71088 (EMBL:Z82044) hypothetical protein from Bacillus subtilis (258 aa) fasta scores%3B opt: 452%2C z-score: 475.1%2C E(): 4.2e-19%2C (36.6%25 identity in 262 aa overlap). Also similar to TR:CAB45285 (EMBL:AL079332) hypothetical protein from Streptomyces coelicolor (195 aa) fasta scores%3B opt: 572%2C z-score: 600.1%2C E(): 4.6e-26%2C (50.0%25 identity in 184 aa overlap). Contains possible membrane spanning hydrophobic region. gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0247 SCO0248 SCO0248 SCJ9A.27c SCJ9A.27c 237664 238251 - hypothetical protein SCJ9A.27c%2C unknown%2C len: 195aa%3B prediction based on Hidden Markov Model and amino acid usage. gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0248 SCO0249 SCO0249 SCJ9A.28c SCJ9A.28c 238280 239794 - hypothetical protein SCJ9A.28c%2C possible monooxygenase%2C len: 504 aa%3B similar to many e.g. TR:Q9ZGM8 (EMBL:AF077869) oxygenase involved in the last step of mithramycin biosynthesis in Streptomyces argillaceus (533 aa) fasta scores%3B opt: 1215%2C z-score: 1311.5%2C E(): 0%2C (45.0%25 identity in 513 aa overlap). Contains Pfam matches to entry PF01360 Monooxygenase%2C Monooxygenase and Pfam match to entry PF01494 FAD_binding_3%2C and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible uncleavable N-terminal signal sequence. gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0249 SCO0250 SCO0250 SCJ9A.29 SCJ9A.29 239858 240523 + transcriptional regulator SCJ9A.29%2C possible transcriptional regulator%2C len: 221aa%3B similar to many tetR-family transcriptional regulators eg. SW:TER1_ECOLI TetR from Tn1721 of Escherichia coli (216 aa) fasta scores%3B opt: 429%2C z-score: 484.8%2C E(): 1.2e-19%2C (40.7%25 identity in 209 aa overlap). Contains possible helix-turn-helix motif (+4.13 SD) 37-58aa. gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0250 SCO0251 SCO0251 SCJ9A.30c SCJ9A.30c 240559 240843 - hypothetical protein SCJ9A.30c%2C unknown%2C len: 94aa%3B prediction based on Hidden Markov Model. gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0251 SCO0252 SCO0252 SCJ9A.31c SCJ9A.31c 240876 242123 - oxidoreductase SCJ9A.31c%2C possible oxidoreductase%2C len: 415 aa%3B similar to many e.g. TR:AAD25066 (EMBL:AF121000) tetracycline resistance associated oxidoreductase homolog from Corynebacterium glutamicum (402 aa) fasta scores%3B opt: 672%2C z-score: 786.6%2C E(): 0%2C (32.8%25 identity in 390 aa overlap) and SW:TETX_BACFR tetracycline resistance oxidoreductase from Bacteroides fragilis transposons (388 aa) fasta scores%3B opt: 275%2C z-score: 324.5%2C E(): 1e-10%2C (24.9%25 identity in 377 aa overlap). Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0252 SCO0253 SCO0253 SCJ9A.32 SCJ9A.32 242194 242766 + TetR family transcriptional regulator SCJ9A.32%2C probable tetR-family transcriptional regulator%2C len: 190 aa%3B similar to many e.g. SW:TER1_ECOLI TetR tetracycline resistance repressor from Escherichia coli (216 aa) fasta scores%3B opt: 501%2C z-score: 616.1%2C E(): 5.9e-27%2C (44.5%25 identity in 200 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and Prosite match to PS01081 Bacterial regulatory proteins%2C tetR family signature. Contains possible helix-turn-helix motif (+5.97 SD) 26-47 aa gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0253 SCO0254 SCO0254 SCJ9A.33c SCJ9A.33c 243022 243762 - hypothetical protein SCJ9A.33c%2C hypothetical protein%2C len: 246 aa%3B weakly similar to TR:Q18926 (EMBL:U23517) hypothetical protein from the eukaryote Caenorhabditis elegans (243 aa) fasta scores%3B opt: 354%2C z-score: 396.7%2C E(): 9.9e-15%2C (28.3%25 identity in 240 aa overlap). Also weakly similar to TR:O87611 (EMBL:AF087482) dienelactone hydrolase from Pseudomonas aeruginosa (236 aa) fasta scores%3B opt: 212%2C z-score: 241.9%2C E(): 4.1e-06%2C (27.4%25 identity in 230 aa overlap). Similar also to TR:Q9I4H1 (EMBL:AE004547) Pseudomonas aeruginosa hypothetical protein PA1166%2C 262 aa%3B fasta scores: opt: 474 Z-score: 515.3 E(): 4.5e-21%3B 35.000%25 identity in 240 aa overlap gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0254 SCO0255 SCO0255 SCF20.01c SCF20.01c 243936 245672 - sigma factor SCF20.01c%2C possible transcriptional regulator%2C len: >476aa%3B weakly similar to the N-terminal region of many transcriptional regulator eg. SW:ACOR_ALCEU acetoin catabolism regulatory protein from Alcaligenes eutrophus (668 aa) fasta scores%3B opt: 288%2C z-score: 292.1%2C E(): 6.6e-09%2C (26.8%25 identity in 496 aa overlap). Contains Pfam match to entry PF00158 sigma54%2C Sigma-54 transcription factors and Prosite match to PS00675 Sigma-54 interaction domain ATP-binding region A signature.~SCJ9A.34c%2C partial CDS%2C possible transcriptional regulator%2C len: >185aa%3B similar to C-terminal region of many eg. SW:HYDG_SALTY hydrogenase regulatory gene from Salmonella typhimurium (441 aa) fasta scores%3B opt: 207%2C z-score: 258.1%2C E(): 5.2e-07%2C (31.3%25 identity in 134 aa overlap). Contains Pfam match to entry PF00158 sigma54%2C Sigma-54 transcription factors. Contains possible helix-turn-helix motif (+4.35 SD) 155-176aa. gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0255 SCO0256 SCO0256 SCF20.02 SCF20.02 245986 246783 + short chain oxidoreductase SCF20.02%2C possible short chain oxidoreductase%2C len: 265aa%3B similar to many oxidoreductases e.g. TR:Q9ZNN8 (EMBL:AB009078) L-2%2C3-butanediol dehydrogenase from Corynebacterium glutamicum (258 aa) fasta scores%3B opt: 784%2C z-score: 848.0%2C E(): 0%2C (49.4%25 identity in 255 aa overlap). Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase and to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0256 SCO0257 SCO0257 SCF20.03 SCF20.03 246868 247869 + hypothetical protein SCF20.03%2C hypothetical protein%2C len: 333 aa%3B similar to TR:Q9Y9P8 (EMBL:AP000063) hypothetical protein APE2240 from Aeropyrum pernix (324 aa) fasta scores%3B opt: 728%2C z-score: 908.5%2C E(): 0%2C (51.7%25 identity in 298 aa overlap) gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0257 SCO0258 SCO0258 SCF20.04 SCF20.04 247871 248680 + hypothetical protein SCF20.04%2C hypothetical protein%2C len: 269 aa%3B similar to TR:BAA81254 (EMBL:AP000063) hypothetical protein from Aeropyrum pernix (238 aa) fasta scores%3B opt: 228%2C z-score: 274.4%2C E(): 6.4e-08%2C (29.7%25 identity in 232 aa overlap). gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0258 SCO0259 SCO0259 SCF1.01 SCF1.01 248677 249702 + alcohol dehydrogenase SCF1.01%2C partial CDS%2C probable alcohol dehydrogenase%2C len: >167aa%3B similar the C-terminal region of many eg. SW:ADH3_SULSO NAD-dependent alcohol dehydrogenase from Sulfolobus solfataricus (347 aa) fasta scores%3B opt: 274%2C z-score: 304.7%2C E(): 1.3e-09%2C (31.8%25 identity in 170 aa overlap). Also similar to C-terminal region of TR:BAA82700 (EMBL:AB017438) from Streptomyces coelicolor (346 aa) fasta scores%3B opt: 372%2C z-score: 409.3%2C E(): 2e-15%2C (40.7%25 identity in 167 aa overlap).~SCF20.05%2C probable alcohol dehydrogenase (zinc-binding)%2C len: >236aa%3B similar to many eg. alcohol dehydrogenases eg. SW:ADH1_SULSO NAD-dependent alcohol dehydrogenase from Sulfolobus solfataricus (347 aa) fasta scores%3B opt: 476%2C z-score: 530.0%2C E(): 3.7e-22%2C (35.4%25 identity in 243 aa overlap). Also similar to TR:BAA82700 (EMBL:AB017438) hypothetical protein from Streptomyces coelicolor (346 aa) fasta scores%3B opt: 591%2C%2C z-score: 655.8%2C E(): 3.7e-29%2C (42.8%25 identity in 243 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and Prosite match to PS00059 Zinc-containing alcohol dehydrogenases signature. gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0259 SCO0260 SCO0260 SCF1.02 SCF1.02 249755 250084 + hypothetical protein SCF1.02%2C unknown%2C len: 109 aa%3B similar to TR:O06569 (EMBL:Z95585) hypothetical protein from Mycobacterium tuberculosis (107 aa) fasta scores%3B opt: 433%2C z-score: 595.2%2C E(): 8.7e-26%2C (56.6%25 identity in 106 aa overlap) gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0260 SCO0261 SCO0261 SCF1.03c SCF1.03c 250164 250691 - acetyltransferase SCF1.03c%2C probable acetyltransferase%2C len: 175 aa%3B similar to many e.g. SW:MAA_ECOLI maltose O-acetyltransferase from Escherichia coli (182 aa) fasta scores%3B opt: 365%2C z-score: 432.1%2C E(): 1.1e-16%2C (43.6%25 identity in 140 aa overlap). Contains Pfam match to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) and Prosite match to PS00101 Hexapeptide-repeat containing-transferases signature gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0261 SCO0262 SCO0262 SCF1.04 SCF1.04 250805 251740 + LysR family transcriptional regulator SCF1.04%2C probable LysR-family transcriptional regulator%2C len: 311 aa%3B similar to many transcriptional regulators especially in the N-terminal region%2C e.g. SW:OXYR_MYCAV regulator of hydrogen peroxide responsive genes from Mycobacterium avium (311 aa) fasta scores%3B opt: 292%2C z-score: 329.4%2C E(): 5.5e-11%2C (36.6%25 identity in 191 aa overlap). Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and Prosite match to PS00044 Bacterial regulatory proteins%2C lysR family signature. gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0262 SCO0263 SCO0263 SCF1.05c SCF1.05c 251764 252879 - oxidoreductase SCF1.05c%2C possible oxidoreductase%2C len: 371 aa%3B weakly similar to many e.g. TR:O69945 (EMBL:AL023862) oxidoreductase from Streptomyces coelicolor (430 aa) fasta scores%3B opt: 224%2C z-score: 247.7%2C E(): 2e-06%2C (26.0%25 identity in 392 aa overlap). Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0263 SCO0264 SCO0264 SCF1.06 SCF1.06 252946 253398 + transcriptional regulator SCF1.06%2C possible transcriptional regulator%2C len: 150 aa%3B weakly similar to many e.g. TR:AAD32748 (EMBL:AF127374) transcriptional repressor from Streptomyces lavendulae (163 aa) fasta scores%3B opt: 142%2C z-score: 184.9%2C E(): 0.0062%2C (27.3%25 identity in 128 aa overlap). Contains Pfam match to entry PF01047 MarR%2C MarR family and probable helix-turn-helix motif (+3.47 SD) 68-89aa. gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0264 SCO0265 SCO0265 SCF1.07 SCF1.07 253499 254290 + hydroxylase SCF1.07%2C possible hydroxylase%2C len: 263 aa%3B similar to many from Streptomyces sp. eg. TR:Q55078 (EMBL:U50973) daunomycin C-14 hydroxylase from Streptomyces sp. strain C5 (275 aa) fasta scores%3B opt: 302%2C z-score: 356.8%2C E(): 1.7e-12%2C (39.3%25 identity in 270 aa overlap). Also similar to TR:CAB45588 (EMBL:AL079355) hydroxylase from Streptomyces coelicolor (263 aa) fasta scores%3B opt: 746%2C z-score: 870.2%2C E(): 0%2C (44.3%25 identity in 262 aa overlap). gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0265 SCO0266 SCO0266 SCF1.08c SCF1.08c 254332 255309 - transcriptional regulator SCF1.08c%2C possible transcriptional regulator%2C len: 325aa%3B similar to many eg. TR:CAB43482 (EMBL:Y18527) PobR regulator from Pseudomonas sp. strain HR199 (293 aa) fasta scores%3B opt: 254%2C z-score: 302.3%2C E(): 1.8e-09%2C (30.3%25 identity in 254 aa overlap). Also similar to TR:O88020 (EMBL:AL031107) transcriptional regulator from Streptomyces coelicolor (301 aa) fasta scores%3B opt: 318%2C z-score: 376.7%2C E(): 1.3e-13%2C (37.2%25 identity in 253 aa overlap). Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. gene gene253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0266 SCO0267 SCO0267 SCF1.09 SCF1.09 255311 256087 + hydrolase SCF1.09%2C possible hydrolase%2C len: 258 aa%3B similar to many e.g. TR:O67982 (EMBL:AF003947) 3-oxoadipate enol-lactone hydrolase from Rhodococcus opacus (400 aa) fasta scores%3B opt: 259%2C z-score: 300.%2C1 E(): 2.4e-09%2C (31.5%25 identity in 251 aa overlap). Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0267 SCO0268 SCO0268 SCF1.10 SCF1.10 256281 256442 + hypothetical protein SCF1.10%2C unknown%2C len:53 aa gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0268 SCO0269 SCO0269 SCF1.11 SCF1.11 256526 259687 + hypothetical protein SCF1.11%2C unknown%2C len: 1053aa%3B similar to large proteins thought to be involved in the post-translational modification of lantibiotics eg. SW:SPAB_BACSU subtilin modification protein from Bacillus subtilis (1030 aa) fasta scores%3B opt: 346%2C z-score: 367.5%2C E(): 4.2e-13%2C (22.6%25 identity in 1041 aa overlap). gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0269 SCO0270 SCO0270 SCF1.12 SCF1.12 259684 261084 + hypothetical protein SCF1.12%2C unknown%2C len: 466 aa%3B similar to proteins predicted to be involved in lantibiotic biosynthesis eg. SW:SPAC_BACSU subtilin biosynthesis protein from Bacillus subtilis (441 aa) fasta scores%3B opt: 502%2C z-score: 549.2%2C E(): 3.2e-23%2C (28.9%25 identity in 405 aa overlap) gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0270 SCO0271 SCO0271 SCF1.13 SCF1.13 261366 262319 + binding-protein-dependent transport protein SCF1.13%2C possible binding-protein-dependent transport protein%2C len: 317aa%3B similar to many predicted membrane transporters eg. TR:CAB41203 (EMBL:AL049661) binding-protein-dependent transport protein from Streptomyces coelicolor (327 aa) fasta scores%3B opt: 624%2C z-score: 720.7%2C E(): 8.8e-33%2C (35.9%25 identity in 320 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible membrane spanning hydrophobic regions. gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0271 SCO0272 SCO0272 SCF1.14 SCF1.14 262330 263220 + binding-protein-dependent transport protein SCF1.14%2C possible binding-protein-dependent transport protein%2C len: 296aa%3B similar to many predicted membrane transporters eg. TR:O53483 (EMBL:AL021899) sugar transport protein from Mycobacterium tuberculosis (280 aa) fasta scores%3B opt: 594%2C z-score: 708.0%2C E(): 4.5e-32%2C (34.6%25 identity in 283 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible membrane spanning hydrophobic regions. gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0272 SCO0273 SCO0273 SCF1.15 SCF1.15 263285 264634 + substrate binding protein SCF85.01%2C unknown%2C partial CDS%2C len: >264 aa. Weakly similar to several hypotheticals e.g. Mycobacterium tuberculosis TR:O53485 (EMBL%3B AL021899) lipoprotein component of sugar transport system (439 aa)%2C fasta scores opt: 258 z-score: 307.2 E(): 9.3e-10 27.9%25 identity in 222 aa overlap and Thermotoga maritima TR:AAD35892 (EMBL%3B AE001748) sugar ABC transporter%2C periplasmic sugar-binding protein TM0810 (420 aa)%2C fasta scores opt: 169 z-score: 203.2 E(): 0.00058 25.1%25 identity in 263 aa overlap.~SCF1.15%2C partial CDS%2C possible substrate binding protein (extracellular) (binding-protein-dependent transport)%2C len: >221aa%3B similar to many the N-terminal region of undefined function eg. SW:YURO_BACSU hypothetical ABC transporter extracellular binding protein from Bacillus subtilis (422 aa) fasta scores%3B opt: 224%2C z-score: 276.0%2C E(): 5.2e-08%2C (26.1%25 identity in 161 aa overlap). Contains possible N-terminal signal sequence. gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0273 SCO0274 SCO0274 SCF85.02 SCF85.02 264764 266263 + alpha-galactosidase SCF85.02%2C possible alpha-galactosidase%2C len: 499 aa. Similar to many alpha galactosidases e.g. Thermus aquaticus TR:AAD32628(EMBL%3B AF135399) alpha-galactosidase (476 aa)%2C fasta scores opt: 1329 z-score: 1530.0 E(): 0 45.8%25 identity in 487 aa overlap gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0274 SCO0275 SCO0275 SCF85.03 SCF85.03 266356 267513 + transcriptional repressor protein SCF85.03%2C possible transcriptional repressor protein%2C len: 385 aa. Low similarity to many repressor proteins e.g. Anaerocellum thermophilum SW:XYLR_ANATH (EMBL%3B Z69782)xylose repressor (399 aa)%2C fasta scores opt: 325 z-score: 375.7 E(): 1.4e-13 23.3%25 identity in 395 aa overlap and Streptomyces coelicolor TR:O50502 (EMBL%3B AL009199) probable transcriptional repressor protein SC7B7.05 (403 aa)%2C fasta scores opt: 402 z-score: 463.7 E(): 1.8e-18 29.7%25 identity in 404 aa overlap. Contains a Pfam match to entry PF00480 ROK%2C ROK family and has a possible helix turn helix motif between aa 30..51. gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0275 SCO0276 SCO0276 SCF85.04 SCF85.04 267585 268838 + oxidoreductase SCF85.04%2C possible oxidoreductase%2C len: 417 aa. Weakly similar to many including: Bacillus subtilis TR:O34371 (EMBL:AF008220) YteT (428 aa)%2C fasta scores opt: 296 z-score: 340.2 E(): 1.3e-11 25.3%25 identity in 379 aa overlap and Alcaligenes sp. (strain BR60) SW:CBAC_ALCSB (EMBL%3B U18133) 1-carboxy-3-chloro-3%2C4-dihydroxycyclo hexa-1%2C5-diene dehydrogenase (497 aa)%2C fasta scores opt: 300 z-score: 345.3 E(): 7e-12 32.4%25 identity in 216 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0276 SCO0277 SCO0277 SCF85.05c SCF85.05c 269020 269688 - hypothetical protein SCF85.05c%2C unknown%2C len:222 aa. Low similarity to Haemophilus influenzae SW:PEPE_HAEIN (EMBL%3B U32740) peptidase E (EC 3.4.-.-) (alpha-aspartyl dipeptidase) (226 aa)%2C fasta scores opt: 134 z-score: 169.6 E(): 0.043 24.4%25 identity in 209 aa overlap. gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0277 SCO0278 SCO0278 SCF85.06 SCF85.06 269783 270397 + MutT domain-containing protein SCF85.06%2C MutT domain containing protein%2C len: 204. Similar to the MutT domains of other proteins e.g. Bacillus subtilis SW:YZGD_BACSU (EMBL:U17168) hypothetical 45.4 KD protein in thiaminase (413 aa)%2C fasta scores opt: 138 z-score: 176.6 E(): 0.017 36.1%25 identity in 97 aa overlap. Contains a Pfam match to entry PF00293 mutT%2C Bacterial MutT protein. gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0278 SCO0279 SCO0279 SCF85.07 SCF85.07 270477 271748 + glycosyl hydrolase SCF85.07%2C possible glycosyl hydrolase%2C len%3B 423 aa. Shares a low level of similarity with many alpha-l-fucosidases e.g. Thermotoga maritima TR:AAD35394 (EMBL:AE001712) alpha-l-fucosidase%2C (449 aa)%2C fasta scores opt: 332 z-score: 363.4 E(): 6.9e-13 35.8%25 identity in 358 aa overlap. gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0279 SCO0280 SCO0280 SCF85.08c SCF85.08c 271768 272469 - hypothetical protein SCF85.08c%2C unknown%2C len: 233 aa. Weakly similar to many hypotheticals e.g. Haemophilus influenzae SW:YQIE_HAEIN (EMBL%3B U32723) hypothetical protein HI0398 (217 aa)%2C fasta scores opt: 291 z-score: 349.5 E(): 4.1e-12 31.8%25 identity in 179 aa overlap. Contains a PS00017 ATP/GTP-binding site motif A (P-loop). gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0280 SCO0281 SCO0281 SCF85.09c SCF85.09c 272466 272834 - hypothetical protein SCF85.09c%2C unknown%2C len: 122 aa. gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0281 SCO0282 SCO0282 SCF85.10 SCF85.10 272892 273656 + deoR family transcriptional regulator SCF85.10%2C probable deoR family transcriptional regulator%2C len: 254 aa%3B similar to many transcriptional regulators of the deoR family e.g. Bacillus subtilis TR:P94591 (EMBL:Z83337) similar to phosphotransferase system regulator (258 aa)%2C fasta scores opt: 433 z-score: 500.9 E(): 1.5e-20 33.5%25 identity in 254 aa overlap. Contains a PS00894 Bacterial regulatory proteins%2C deoR family signature and a Pfam match to entry PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family. Has a possible helix turn helix motif between aa 23..44. gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0282 SCO0283 SCO0283 SCF85.11c SCF85.11c 274101 274595 - hypothetical protein SCF85.11c%2C unknown%2C len: 164 aa. gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0283 SCO0284 SCO0284 SCF85.12 SCF85.12 274763 276805 + alpha-galactosidase SCF85.12%2C possible alpha-galactosidase%2C len: 680 aa. Highly similar to many Eukaryotic alpha-galactosidases over the first 415 aa%2C e.g. Coffea arabica (Coffee) alpha-galactosidase precursor (EC 3.2.1.22) (melibiase) (378 aa)%2Copt: 1323 z-score: 1416.9 E(): 0%3B 54.5%25 identity in 354 aa overlap%2C in addition to Saccharopolyspora erythraea (Streptomyces erythraeus)alpha galactosidase precursor MelA (428 aa)%2Cfasta scores opt: 623 z-score: 668.6 E(): 6.9e-30 50.6%25 identity in 427 aa overlap. Contains a PS00512 Alpha-galactosidase signature%2C a PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site and a possible N-terminal signal sequence gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0284 SCO0285 SCO0285 SCF85.13 SCF85.13 276938 278827 + sodium/proton antiporter SCF85.13%2C possible sodium/proton antiporter%2C len: 629 aa. Similar to many including Streptomyces coelicolor TR:CAB38501 (EMBL%3B AL035636) sodium/proton antiporter SCH5.27 (474 aa)%2C fasta scores opt: 603 z-score: 691.3 E(): 3.7e-31 37.7%25 identity in 454 aa overlap. This protein is longer than most of the similar antiporter proteins. The additional C-terminal sequence has similarity to many outer membrane proteins e.g. Coxiella burnetii TR:O07645 (EMBL%3B AB004699) 27KDA outer membrane protein (252 aa)%2C fasta scores opt: 250 z-score: 291.5 E():c7e-09 28.6%25 identity in 140 aa overlap. Contains membrane spanning hydrophobic domains. gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0285 SCO0286 SCO0286 SCF85.14c SCF85.14c 278910 279416 - peptidoglycan binding protein SCF85.14c%2C possible peptidoglycan binding protein%2C len: 168 aa. Some similarity to N-acetylmuramoyl-L-alanine amidases over the peptidoglycan binding domains e.g. Bacillus subtilis SW:CWLA_BACSU (EMBL%3B X51424) (272 aa)%2C fasta scores opt: 127 z-score: 157.1 E():0.21 34.9%25 identity in 63 aa overlap. Contains a Pfam match to entry PF01471 PG_binding_1%2C peptidoglycan binding domain. Contains a possible N-terminal signal sequence gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0286 SCO0287 SCO0287 SCF85.15 SCF85.15 279691 280695 + regulatory protein SCF85.15%2C possible regulatory protein%2C len: 334 aa. similar to many e.g. Rhodococcus rhodochrous TR:P72312 (EMBL%3B D67026) nitrilase regulator NitR (319 aa)%2C fasta scores opt: 538 z-score: 658.4 E(): 2.5e-29 30.6%25 identity in 307 aa overlap and tp SW:FEAR_ECOLI (EMBL:D67041) Escherichia coli transcriptional activator FeaR%2C 301 aa%3B fasta scores: opt: 290 Z-score: 343.6 E(): 1.7e-11%3B 23.970%25 identity in 267 aa overlap. Contains a Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0287 SCO0288 SCO0288 SCF85.16 SCF85.16 280692 281132 - hypothetical protein SCF85.16%2C unknown%2C len: 146 aa. gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0288 SCO0289 SCO0289 SCF85.17c SCF85.17c 281129 282157 - transcriptional regulator SCF85.17c%2C probable transcriptional regulator%2C len: 342 aa. Similar to many e.g. Streptomyces lividans TR:Q9ZI18 (EMBL%3B AF043654) BxlR (338 aa)%2C fasta scores opt: 753 z-score: 849.8 E(): 0 42.9%25 identity in 333 aa overlap and Streptomyces coelicolor TR:O86795 (EMBL%3B AL031317) transcriptional regulator SC6G4.32 (355 aa)%2C fasta scores opt: 880 z-score: 991.6 E(): 0 47.5%25 identity in 339 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and a PS00356 Bacterial regulatory proteins%2C lacI family signature. Has a helix turn helix motif between aa 9..30 gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0289 SCO0290 SCO0290 SCF85.18 SCF85.18 282491 283801 + solute-binding protein SCF85.18%2C probable solute-binding protein%2C len: 436 aa. Similar to many including: Streptomyces lividans TR:Q9Z492 (EMBL%3B AF043654) BxlE precursor (434 aa)%2C fasta scores opt: 946 z-score: 1058.6 E(): 0 33.7%25 identity in 427 aa overlap and Streptococcus mutans SW:MSME_STRMU (EMBL%3B M77351) multiple sugar-binding protein precursor MsmE (420 aa)%2C fasta scores opt: 258 z-score: 291.6 E(): 6.9e-09 24.2%25 identity in 351 aa overlap. Contains a Pfam match to entry PF01547 SBP_bacterial_1%2C PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a possible N-terminal signal sequence. gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0290 SCO0291 SCO0291 SCF85.19 SCF85.19 283798 284700 + binding protein dependent transport protein SCF85.19%2C possible binding protein dependent transport protein%2C len: 300 aa. Similar to many including: Streptomyces lividans TR:Q9ZI17 (EMBL%3B AF043654) BxlF (317 aa)%2C fasta scores opt: 873 z-score: 1049.2 E(): 0 44.0%25 identity in 298 aa overlap and Streptomyces coelicolor TR:CAB41203 (EMBL%3B AL049661)binding protein dependent transport protein SCE134.05C (327 aa)%2C fasta scores opt: 551 z-score: 664.3 E(): 1.2e-29 32.7%25 identity in 294 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and a PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains multiple membrane-spanning hydrophobic domains. gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0291 SCO0292 SCO0292 SC5G9.01 SC5G9.01 284702 285598 + sugar ABC-transporter integral membrane protein SC5G9.01%2C probable sugar ABC-transporter integral membrane protein%2C partial CDS%2C len: >148 aa%3B similar to e.g. TR:O51925 (EMBL:AF012836)%2C malG%2C Thermococcus litoralis inner membrane protein from trehalose/maltose ABC-transporter system (278 aa)%2C fasta scores%3B opt: 296 z-score: 384.7 E(): 4.6e-14%2C 32.2%25 identity in 146 aa overlap. Also similar to many ABC-transporter components e.g. SW:YOR2_CALSR (EMBL:L18965) Caldicellulosiruptor sp. (strain Rt8B.4) membrane bound sugar transport protein ORF2 (275 aa) (43.0%25 identity in 142 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component~SCF85.20%2C possible transmembrane transport protein%2C partial CDS%2C len: >185 aa. Similar to Streptomyces lividans TR:Q9ZI16 (EMBL%3B AF043654) BxlG (272 aa)%2C fasta scores opt: 377 z-score: 450.9 E(): 9.2e-18 39.9%25 identity in 158 aa overlap and Streptomyces coelicolor TR:O50501 (EMBL%3B AL009199) probable transmembrane transport protein SCSt7b7.04 (302 aa)%2C fasta scores opt: 288 z-score: 346.2 E(): 6.2e-12 29.3%25 identity in 181 aa overlap. Contains multiple potential membrane spanning hydrophobic domains. gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0292 SCO0293 SCO0293 SC5G9.02 SC5G9.02 285714 288104 + beta-xylosidase SC5G9.02%2C probable beta-xylosidase%2C len: 796 aa%3B similar to many xylosidases and glucosidases e.g. TR:Q9ZI15 (EMBL:AF043654)%2C blxA%2C Streptomyces lividans beta-D-xylosidase (861 aa)%2C fasta scores%3B opt: 3669 z-score: 3880.7 E(): 0%2C 71.3%25 identity in 791 aa overlap. Similar to others from S.coelicolor e.g. TR:O87852 (EMBL:AL031013) S.coelicolor probable beta-glucosidase (859 aa) (29.7%25 identity in 811 aa overlap). Contains 2 Pfam matches to entry PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3 gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0293 SCO0294 SCO0294 SC5G9.03c SC5G9.03c 288187 288840 - acetyltransferase SC5G9.03c%2C probable acetyltransferase%2C len: 217 aa%3B similar to many acetyltransferases which inactivate virginiamycin A-like antibiotics by acetylation e.g. SW:SATA_ENTFC (EMBL:L12033)%2C satA%2C Enterococcus faecium streptogramin A acetyltransferase (209 aa)%2C fasta scores%3B opt: 632 z-score: 743.9 E(): 0%2C 43.6%25 identity in 202 aa overlap. Contains Pfam match to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0294 SCO0295 SCO0295 SC5G9.04c SC5G9.04c 288987 290456 - transmembrane efflux protein SC5G9.04c%2C probable transmembrane efflux protein%2C len: 489 aa%3B similar to many e.g. TR:Q54806 (EMBL:X84072)%2C ptr%2C Streptomyces pristinaespiralis multidrug resistance integral membrane protein (501 aa)%2C fasta scores%3B opt: 975 z-score: 1038.5 E(): 0%2C 37.1%25 identity in 421 aa overlap. Similar to others from S.coelicolor e.g. TR:Q9ZBW5 (EMBL:AL034443) S.coelicolor probable integral membrane efflux protein (504 aa) (38.8%25 identity in 484 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions and PS00216 Sugar transport proteins signature 1 gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0295 SCO0296 SCO0296 SC5G9.05 SC5G9.05 290584 291165 + transcriptional regulator SC5G9.05%2C possible transcriptional regulator%2C len: 193 aa%3B similar to several transcriptional regulators e.g. TR:Q54288 (EMBL:X86780) Streptomyces hygroscopicus regulator of antibiotic transport complexes (204 aa)%2C fasta scores%3B opt: 239 z-score: 291.2 E(): 7.5e-09%2C 31.9%25 identity in 182 aa overlap. Similar to TR:O54180 (EMBL:AL021411) S.coelicolor probable transcriptional regulator (203 aa) (35.2%25 identity in 165 aa overlap). Contains probable helix-turn-helix motif at aa 38-59 (Score 1242%2C +3.42 SD) gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0296 SCO0297 SCO0297 SC5G9.06 SC5G9.06 291315 292592 + hypothetical protein SC5G9.06%2C possible hypothetical protein%2C len: 425 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains a probable N-terminal signal sequence gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0297 SCO0298 SCO0298 SC5G9.07c SC5G9.07c 292656 293519 - LysR family transcriptional regulator SC5G9.07c%2C probable lysR-family transcriptional regulator%2C len: 287 aa%3B similar to many e.g. SW:ALSR_BACSU (EMBL:L04470)%2C AlsR%2C Bacillus subtilis regulator of acetoin biosynthesis operon (302 aa)%2C fasta scores%3B opt: 424 z-score: 491.8 E(): 5e-20%2C 31.6%25 identity in 253 aa overlap. Contains probable helix-turn-helix motif at aa 20-41 (Score 1533%2C +4.41 SD). Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and PS00044 Bacterial regulatory proteins%2C lysR family signature gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0298 SCO0299 SCO0299 SC5G9.08 SC5G9.08 293613 294497 + oxidoreductase SC5G9.08%2C possible oxidoreductase%2C len: 294 aa%3B shows weak similarity to TR:P06632 (EMBL:M12799) Corynebacterium sp. 2%2C5-diketo-D-gluconic acid reductase (278 aa)%2C fasta scores%3B opt: 196 z-score: 229.3 E(): 2.1e-05%2C 27.6%25 identity in 286 aa overlap. Similar to many hypothetical oxidoreductases e.g. SW:YDBC_ECOLI (EMBL:X62680)%2C YbcD%2C Escherichia coli hypothetical oxidoreductase (286 aa) (63.3%25 identity in 283 aa overlap). Also similar to SC5H1.28C (EMBL:AL049863) Streptomyces coelicolor oxidoreductase (305 aa) (46.5%25 identity in 301 aa overlap) gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0299 SCO0300 SCO0300 SC5G9.09c SC5G9.09c 294494 296305 - monooxygenase SC5G9.09c%2C probable monooxygenase%2C len: 603 aa%3B similar to several monooxygenases e.g. SW:CYMO_ACISP (EMBL:M19029) Acinetobacter sp cyclohexanone monooxygenase (542 aa)%2C fasta scores%3B opt: 643 z-score: 715.7 E(): 1.7e-32%2C 33.6%25 identity in 518 aa overlap. GC frameplot and codon usage plots suggest the presence of an approx. 50 aa N-terminal extension absent from similar sequences gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0300 SCO0301 SCO0301 SC5G9.10 SC5G9.10 296471 297499 + lipoprotein SC5G9.10%2C possible lipoprotein%2C len: 342 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains a probable N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0301 SCO0302 SCO0302 SC5G9.11c SC5G9.11c 297515 298108 - TetR family transcriptional regulator SC5G9.11c%2C possible tetR-family transcriptional regulator%2C len: 197 aa%3B shows weak similarity to A-factor receptors and their homologues e.g. TR:O66121 (EMBL:AB000384)%2C CprA%2C Streptomyces coelicolor A-factor receptor homologue involved in the regulation of secondary metabolism and morphogenesis (215 aa)%2C fasta scores%3B opt: 168 z-score: 202.3 E(): 0.00066%2C 30.1%25 identity in 193 aa overlap. Contains probable helix-turn-helix motif at aa 43-64 (Score 1686%2C +4.93 SD). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0302 SCO0303 SCO0303 SC5G9.12c SC5G9.12c 298105 298311 - hypothetical protein SC5G9.12c%2C hypothetical protein%2C len: 68 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0303 SCO0304 SCO0304 SC5G9.13c SC5G9.13c 298468 298836 - hypothetical protein SC5G9.13c%2C unknown%2C len: 122 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0304 SCO0305 SCO0305 SC5G9.14 SC5G9.14 299213 302092 + hypothetical protein SC5G9.14%2C hypothetical protein%2C len: 959 aa%3B unknown function%2C similar to TR:O54182 (EMBL:AL021411) Streptomyces coelicolor hypothetical protein (913 aa)%2C fasta scores%3B opt: 698 z-score: 776.6 E(): 0%2C 27.0%25 identity in 972 aa overlap. The C-terminus shows very weak similarity to eukaryotic beta-transducins e.g. SW:GBB4_MOUSE (EMBL:S86124)%2C gnb4%2C Mus musculus guanine nucleotide-binding protein beta subunit 4 (340 aa) (23.0%25 identity in 291 aa overlap). Contains possible hydrophobic membrane spanning region gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0305 SCO0306 SCO0306 SC5G9.15c SC5G9.15c 302056 302961 - gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0306 SCO0307 SCO0307 SC5G9.16 SC5G9.16 303084 303971 + DNA-binding protein SC5G9.16%2C possible DNA-binding protein%2C len: 295 aa%3B probable CDS suggested by GC frameplot and positional base preference. Similar to possible DNA-binding proteins from S. coelicolor e.g. SCJ9A.15c (cosmid SCJ9A)%2C S. coelicolor possible DNA-binding protein (290 aa) (39.3%25 identity in 298 aa overlap). Contains probable helix-turn-helix motif at residues 35-56 (Score 1197%2C +3.26 SD) gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0307 SCO0308 SCO0308 SC5G9.17 SC5G9.17 304026 305429 + hypothetical protein SC5G9.17%2C possible membrane protein%2C len: 467 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains hydrophobic%2C possible membrane-spanning regions near the C-terminus. Contains TTA (leucine) codon%3B possible target for bldA regulation gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0308 SCO0309 SCO0309 SC5G9.18c SC5G9.18c 305537 306625 - amide hydrolase SC5G9.18c%2C probable amide hydrolase%2C len: 362 aa%3B similar to 6-aminohexanoate-dimer hydrolases which degrade N-(6-aminohexanoyl)-6-aminohexanoate e.g. TR:P75007 (EMBL:K02336)%2C NylB'%2C Flavobacterium sp. (strain K172) 6-aminohexanoic acid linear oligomer hydrolase (EII') (392 aa)%2C fasta scores%3B opt: 531 z-score: 598.0 E(): 6.1e-26%2C 34.1%25 identity in 323 aa overlap gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0309 SCO0310 SCO0310 SC5G9.19c SC5G9.19c 306816 307466 - TetR family transcriptional regulator SC5G9.19c%2C possible tetR-family transcriptional regulator%2C len: 141 aa%3B shows similarity to the N-terminal half of TR:O24741 (EMBL:AB001683)%2C FarA%2C Streptomyces sp. strain FRI-5 receptor for an extracellular regulatory factor (IM-2) (221 aa)%2C fasta scores%3B opt: 154 z-score: 193.4 E(): 0.0021%2C 36.7%25 identity in 79 aa overlap and to transcriptional regulators. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0310 SCO0311 SCO0311 SC5G9.20 SC5G9.20 307575 309131 + ligase SC5G9.20%2C probable ligase%2C len: 518 aa%3B similar to domains within polyketide synthases e.g. to the N-terminus of TR:Q54297 (EMBL:X86780)%2C RapA%2C Streptomyces hygroscopicus polyketide synthase (8563 aa)%2C fasta scores%3B opt: 815 z-score: 894.4 E(): 0%2C 34.0%25 identity in 509 aa overlap and to SW:DHBE_BACSU (EMBL:U26444)%2C DhbE%2C EntE%2C Bacillus subtilis 2%2C3-dihydroxybenzoate-AMP ligase (539 aa) (31.3%25 identity in 520 aa overlap). Also similar to others from S. coelicolor e.g. TR:Q9Z5A6 (EMBL:AL035478) S. coelicolor probable long-chain-fatty-acid-CoA ligase (541 aa) (35.9%25 identity in 537 aa overlap). Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and PS00455 AMP-binding domain signature gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0311 SCO0312 SCO0312 SC5G9.21 SC5G9.21 309147 310316 + acyl-CoA dehydrogenase SC5G9.21%2C probable acyl-CoA dehydrogenase%2C len: 389 aa%3B similar to both bacterial and eukaryotic acyl-CoA dehydrogenases e.g. SW:ACDS_HUMAN (EMBL:M26393)%2C AcaDS%2C Homo sapiens mitochondrial acyl-CoA dehydrogenase short-chain specific precursor (412 aa)%2C fasta scores%3B opt: 653 z-score: 771.4 E(): 0%2C 34.8%25 identity in 376 aa overlap. Also similar to SCI30A.22C (EMBL:AL096811) Streptomyces coelicolor probable acyl-CoA dehydrogenase. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0312 SCO0313 SCO0313 SC5G9.22 SC5G9.22 310378 311727 + transmembrane transport protein SC5G9.22%2C probable transmembrane transport protein%2C len: 449 aa%3B similar to many transmembrane transporters e.g. SW:DGOT_ECOLI (EMBL:L10328)%2C dgoT%2C Escherichia coli D-galactonate transporter (445 aa)%2C fasta scores%3B opt: 332 z-score: 376.2 E(): 1.4e-13%2C 23.7%25 identity in 438 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0313 SCO0314 SCO0314 SC5G9.23 SC5G9.23 311724 313670 + hypothetical protein SC5G9.23%2C hypothetical protein%2C len: 648 aa%3B unknown function%2C similar to TR:Q52556 (EMBL:M86744)%2C SdsA%2C Pseudomonas sp. alkyl sulfatase which degrades sulfate esters of long-chain primary alcohols (SDS) (528 aa)%2C fasta scores%3B opt: 739 z-score: 806.7 E(): 0%2C 29.7%25 identity in 528 aa overlap%2C but having an N-terminal extension of approx. 140 aa. Similar to TR:Q48790 (EMBL:X92423)%2C SepA%2C Listeria monocytogenes gene implicated in cell separation (391 aa) (42.6%25 identity in 364 aa overlap). Also similar to hypothetical proteins e.g. TR:O69728 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical protein (626 aa) (52.9%25 identity in 624 aa overlap). Contains Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily. Contains possible N-terminal region signal sequence peptide gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0314 SCO0315 SCO0315 SC5G9.24c SC5G9.24c 313697 315055 - decarboxylase SC5G9.24c%2C probable decarboxylase%2C len: 452 aa%3B similar to many e.g. SW:DCDA_BACSU (EMBL:L09228)%2C LysA%2C Bacillus subtilis diaminopimelate decarboxylase (441 aa)%2C fasta scores%3B opt: 484 z-score: 542.1 E(): 7.9e-23%2C 31.6%25 identity in 389 aa overlap. Similar to TR:Q9ZBH5 (EMBL:AL035206)%2C DcdA%2C Streptomyces coelicolor diaminopimelate decarboxylase (440 aa)%2C fasta scores%3B opt: 400 z-score: 384.5 E(): 3.6e-16%2C 30.2%25 identity in 427 aa overlap. Contains 2 Pfam matches to entry PF00278 Orn_DAP_Arg_deC%2C Pyridoxal-dependent decarboxylase%2C PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2 and PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0315 SCO0316 SCO0316 SC5G9.25c SC5G9.25c 315254 316921 - DNA-binding protein SC5G9.25c%2C hypothetical protein%2C len: 555 aa%3B similar to hypothetical proteins e.g. TR:O50442 (EMBL:AL010186) Mycobacterium tuberculosis hypothetical protein (538 aa)%2C fasta scores%3B opt: 485 z-score: 521.2 E(): 1.2e-21%2C 32.6%25 identity in 568 aa overlap and to TR:Q9Z561 (EMBL:AL035569) S.coelicolor transcriptional regulator (415 aa) (28.4%25 identity in 444 aa overlap). Contains probable helix-turn-helix motif at aa 505-526 (Score 1081%2C +2.87 SD) gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0316 SCO0317 SCO0317 SC5G9.26c SC5G9.26c 316975 318237 - transmembrane transport protein SC5G9.26c%2C probable transmembrane transport protein%2C len: 420 aa%3B shows weak similarity to many efflux pumps e.g. SW:CMLR_STRLI (EMBL:X59968)%2C cmlR%2C Streptomyces lividans chloramphenicol resistance protein (392 aa)%2C fasta scores%3B opt: 276 z-score: 292.9 E(): 6e-09%2C 27.3%25 identity in 407 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0317 SCO0318 SCO0318 SC5G9.27c SC5G9.27c 318329 319345 - oxidoreductase SC5G9.27c%2C possible oxidoreductase%2C len: 388 aa%3B shows weak similarity to many eukaryotic and bacterial oxidoreductases e.g. TR:Q39617 (EMBL:U36752)%2C LpcR-1%2C Chlamydomonas reinhardtii NADPH:protochlorophyllide oxidoreductase (397 aa)%2C fasta scores%3B opt: 278 z-score: 296.3 E(): 3.8e-09%2C 27.4%25 identity in 343 aa overlap. Similar to TR:O53726 (EMBL:AL021932) Mycobacterium tuberculosis oxidoreductase (311 aa) (41.1%25 identity in 309 aa overlap). Similar to others from S. coelicolor e.g. SCJ9A.19c (cosmid SCJ9A)%2C possible oxidoreductase (311 aa) (39.6%25 identity in 303 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0318 SCO0319 SCO0319 SC5G9.28c SC5G9.28c 319499 320008 - hypothetical protein SC5G9.28c%2C unknown%2C len: 169 aa%3B probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0319 SCO0320 SCO0320 SC5G9.29 SC5G9.29 320110 320583 + hypothetical protein SC5G9.29%2C hypothetical protein%2C len: 157 aa%3B similar to the C-terminal half of SW:QOR_PSEAE (EMBL:X85015)%2C qor%2C Pseudomonas aeruginosa quinone oxidoreductase (325 aa)%2C fasta scores%3B opt: 223 z-score: 254.4 E(): 8.3e-07%2C 34.8%25 identity in 161 aa overlap and the corresponding region of many similar hypothetical proteins. Also similar to regions of polyketide synthase-type proteins e.g. SW:MCAS_MYCBO (EMBL:M95808)%2C mas%2C Mycobacterium bovis mycocerosic acid synthase (2110 aa) (35.8%25 identity in 159 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0320 SCO0321 SCO0321 SC5G9.30 SC5G9.30 320699 322255 + carboxylesterase SC5G9.30%2C probable carboxylesterase%2C len: 518 aa%3B similar to many eukaryotic and bacterial e.g. SW:PNBA_BACSU (EMBL:U06089)%2C PrnbA%2C Bacillus subtilis 4-nitrobenzyl esterase (489 aa)%2C fasta scores%3B opt: 718 z-score: 774.9 E(): 0%2C 36.3%25 identity in 479 aa overlap. Similar to TR:Q9Z545 (EMBL:AL035212) Streptomyces coelicolor probable carboxylesterase (502 aa) (41.3%25 identity in 521 aa overlap). Contains 2 Pfam matches to entry PF00135 COesterase%2C Carboxylesterases and PS00122 Carboxylesterases type-B serine active site gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0321 SCO0322 SCO0322 SC5G9.31c SC5G9.31c 322244 323938 - ABC transport ATP-binding subunit SCF12.01c%2C possible ABC transport ATP-binding subunit%2C len: >230aa%3B similar to many eg. SW:TLRC_STRFR tylosin resistance ATP-binding protein from Streptomyces fradiae (548 aa) fasta scores%3B opt: 1017%2C z-score: 1131.8%2C E(): 0%2C (69.0%25 identity in 232 aa overlap). Contains Prosite match to PS00211 ABC transporters family signature and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).~SC5G9.31c%2C probable ABC-transporter ATP-binding protein%2C partial CDS%2C len: >371 aa%3B similar ATP-binding components from antibiotic resistance export systems e.g. SW:TLRC_STRFR (EMBL:M57437)%2C tlrC%2C Streptomyces fradiae tylosin resistance ATP-binding protein (548 aa)%2C fasta scores%3B opt: 1517 z-score: 1597.3 E(): 0%2C 67.4%25 identity in 356 aa overlap. Also similar to many other ABC-transporter ATP-binding proteins. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0322 SCO0323 SCO0323 SCF12.02c SCF12.02c 324467 325069 - hypothetical protein SCF12.02c%2C unknown%2C len: 200aa gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0323 SCO0324 SCO0324 SCF12.03c SCF12.03c 325238 327616 - hypothetical protein SCF12.03c%2C possible hypothetical protein%2C len: 799 aa%3B similar to TR:CAC45838 (EMBL:AL591786) Rhizobium meliloti (Sinorhizobium meliloti) hypothetical transmembrane protein (fragment) SMC01907%2C 729 aa%3B fasta scores: opt: 492 Z-score: 517.1 E(): 3.6e-21%3B 42.318%25 identity in 742 aa overlap. Contains possible cleavable N-terminal signal sequence gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0324 SCO0325 SCO0325 SCF12.04 SCF12.04 327899 328264 + hypothetical protein SCF12.04%2C unknown%2C len: 121aa gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0325 SCO0326 SCO0326 SCF12.05 SCF12.05 328333 329301 + hypothetical protein SCF12.05%2C hypothetical protein%2C len: 322 aa%3B similar to TR:O54173 (EMBL:AL021411) hypothetical protein from Streptomyces coelicolor (382 aa) fasta scores%3B E(): 6.7e-12%2C 34.2%25 identity in 371 aa overlap. gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0326 SCO0328 SCO0328 SCF12.06 SCF12.06 329321 330174 + gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0328 SCO0329 SCO0329 SCF12.08 SCF12.08 330235 331365 + esterase SCF12.08%2C possible esterase len: 376 aa%3B similar to many e.g. TR:O87861 (EMBL:Z15137) esterase A from Streptomyces chrysomallus (389 aa) fasta scores%3B opt: 503%2C z-score: 581.9%2C E(): 4.6e-25%2C 34.9%25 identity in 378 aa overlap gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0329 SCO0330 SCO0330 fabG fabG 331504 332253 + 3-ketoacyl-ACP reductase catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0330 SCO0331 SCO0331 SCF12.10 SCF12.10 332311 333210 + short chain oxidoreductase SCF12.10%2C possible short chain oxidoreductase ( hypothetical protein)%2C len: 299 aa%3B similar to many e.g. TR:CAB51136 (EMBL:Y18817) short chain oxidoreductase from actinorhodin biosynthesis cluster of Streptomyces coelicolor (276 aa) fasta scores%3B opt: 358%2C z-score: 403.3%2C E(): 4.1e-15%2C 34.6%25 identity in 280 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0331 SCO0332 SCO0332 SCF12.11 SCF12.11 333529 334149 + transcriptional regulator SCF12.11%2C possible transcriptional regulator%2C len: 206 aa%3B similar to many e.g. TR:AAD31815 (EMBL:AF129856) transcriptional repressor from Pseudomonas fluorescens (208 aa) fasta scores%3B opt: 275%2C z-score: 343.1%2C E(): 9.3e-12%2C 30.0%25 identity in 200 aa overlap. Contains probable helix-turn-helix motif (+5.38 SD) 45-66aa. gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0332 SCO0333 SCO0333 SCF12.12c SCF12.12c 334223 335734 - dioxygenase SCF12.12c%2C possible dioxygenase (hypothetical protein)%2C len: 503 aa%3B similar to many of undefined function and to TR:Q53353 (EMBL:S65040) lignostilbene-alpha%2Cbeta-dioxygenase from Pseudomonas paucimobilis (485 aa) fasta scores%3B opt: 529%2C z-score: 596.3%2C E(): 7.3e-26%2C (31.6%25 identity in 493 aa overlap) gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0333 SCO0334 SCO0334 SCF12.13 SCF12.13 335948 336292 + hypothetical protein SCF12.13%2C hypothetical protein%2C len: 111 aa gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0334 SCO0335 SCO0335 SCF12.14 SCF12.14 336333 339467 + hypothetical protein SCF12.14%2C hypothetical protein%2C len: 1044 aa gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0335 SCO0336 SCO0336 SCF12.15c SCF12.15c 339521 340630 - hypothetical protein SCF12.15c%2C possible integral membrane protein%2C len: 369aa%3B contains possible membrane spanning hydrophobic regions. gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0336 SCO0337 SCO0337 SCF12.16 SCF12.16 340752 341318 + transcriptional regulator SCF12.16%2C probable transcriptional regulator%2C len: 188 aa%3B similar to many transcriptional regulators from Streptomyces spp. e.g. SW:TCMR_STRGA tetracenomycin C transcriptional repressor from Streptomyces glaucescens (226 aa) fasta scores%3B opt: 152%2C z-score: 176.0%2C E(): 0.019%2C 28.1%25 identity in 203 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif (+3.98 SD) 29-50aa. gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0337 SCO0338 SCO0338 SCF12.17c SCF12.17c 341370 341909 - dehydrogenase SCF12.17c%2C possible dehydrogenase%2C len: 179 aa%3B similar to the C-terminal many proposed glucose-6-phosphate dehydrogenase eg. TR:AAD36231 (EMBL:AE001772) from Thermotoga maritima (496 aa) fasta scores%3B opt: 314%2C z-score: 381.8%2C E(): 6.5e-14%2C (42.5%25 identity in 146 aa overlap). Contains Pfam match to entry PF00479 G6PD%2C Glucose-6-phosphate dehydrogenase. gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0338 SCO0339 SCO0339 SCF12.18 SCF12.18 341992 342561 + dehydrogenase SCF12.18%2C possible dehydrogenase%2C len: 189 aa%3B similar to a region from many proposed dehydrogenases e.g. SW:SERA_METJA D-3-phosphoglycerate dehydrogenase from Methanococcus jannaschii (524 aa) fasta scores%3B opt: 415%2C z-score: 508.1%2C E(): 6e-21%2C 40.8%25 identity in 179 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0339 SCO0340 SCO0340 SCF12.19c SCF12.19c 342578 343165 - hypothetical protein SCF12.19c%2C unknown%2C len: 195aa gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0340 SCO0341 SCO0341 SCF12.20c SCF12.20c 343234 345663 - large hypothetical protein SCF12.20c%2C possible large hypothetical protein%2C len: 809 aa%3B similar to TR:CAB36703 (EMBL:AL035521) hypothetical protein from Arabidopsis thaliana (thale cress) (847 aa) fasta scores%3B opt: 903%2C z-score: 959.2%2C E(): 0%2C 38.7%25 identity in 775 aa overlap gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0341 SCO0342 SCO0342 SCF12.21c SCF12.21c 345817 347706 - hypothetical protein SCF41.01c%2C partial CDS%2C possible hypothetical protein%2C len: >350 aa. Contains a possible N-terminal signal sequence.~SCF12.21c%2C partial CDS%2C unknown%2C len: >533aa gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0342 SCO0343 SCO0343 SCF41.02 SCF41.02 347814 348083 + hypothetical protein SCF41.02%2C unknown%2C len: 113 aa. Contains a PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature. gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0343 SCO0344 SCO0344 SCF41.03 SCF41.03 348137 349381 + GntR family transcriptional regulator SCF41.03%2C possible GntR family DNA-binding regulator%2C len: 414 aa. C-terminus similar to Streptomyces coelicolor TR:Q9ZBS9 (EMBL%3B AL034446) GntR family transcriptional regulator SC1A9.23 (273 aa)%2C fasta scores opt: 332 z-score: 363.0 E(): 7.2e-13 31.9%25 identity in 254 aa overlap. The N-terminus is weakly similar to other DNA-binding proteins e.g. Clavibacter michiganensis subsp. sepedonicus TR:O86023 (EMBL%3B AF079817) transposase (320 aa)%2C fasta scores opt: 158 z-score:0.0 E(): 0.0 30.04%25 identity in 233 aa overlap. Contains a Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. Contains two potential helix- turn-helix motifs: between aa 135..156 score (+5.36 SD) and residues 69..90 score (+4.14 SD). gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0344 SCO0345 SCO0345 SCF41.04c SCF41.04c 349419 350201 - IclR family regulatory protein SCF41.04c%2C probable IclR family regulator ( hypothetical protein)%2C len: 260 aa. Similar to many e.g. Agrobacterium tumefaciens TR:AAD43987 (EMBL:U59485) AttJ (275 aa)%2C fasta scores: opt: 354 z-score: 406.3 E(): 2.8e-15 31.6%25 identity in 237 aa overlap and Streptomyces coelicolor TR:CAB45040 (EMBL:AL078635) transcriptional regulator (248 aa)%2C fasta scores: opt: 333 z-score: 383.3 E(): 5.3e-14 32.3%25 identity in 248 aa overlap. Contains a Pfam match to entry PF01614 IclR. gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0345 SCO0346 SCO0346 SCF41.05 SCF41.05 350474 351352 + 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase SCF41.05%2C possible 2-hydroxyhepta-2%2C4-diene-1%2C7- dioate isomerase%2C len: 292 aa. Similar to many e.g. Mycobacterium leprae TR:O33119 (EMBL%3B Z99263) possible 2-hydroxyhepta-2%2C 4-diene-1%2C7- dioate isomerase (242 aa)%2C fasta scores opt: 491 z-score: 566.1 E(): 3.5e-24 40.6%25 identity in 212 aa overlap%2C Streptomyces coelicolor TR:O86527 (EMBL%3B AL031124) hypothetical 28.2 KD protein SC1C2.27 (261 aa)%2C fasta scores opt: 465 z-score: 479.6 E(): 1.9e-21 40.0%25 identity in 220 aa overlap and to the C-terminus of Escherichia coli SW:HPCE_ECOLI (EMBL%3B X75028) homoprotocatechuate catabolism bifunctional isomerase/decarboxylase (405 aa)%2C fasta scores opt: 479 z-score: 549.1 E(): 3.1e-23 42.8%25 identity in 187 aa overlap. Contains a Pfam match to entry PF01557 FAA_hydrolase. gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0346 SCO0347 SCO0347 SCF41.06 SCF41.06 351529 352779 + racemase SCF41.06%2C possible racemase%2C len: 416 aa. Similar to Pseudomonas putida SW:MANR_PSEPU (EMBL%3B M19043) mandelate racemase (EC 5.1.2.2) (359 aa)%2C fasta scores opt: 322 z-score: 326.6 E(): 7.7e-11 27.9%25 identity in 366 aa overlap. Contains a Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family. This gene is duplicated on this cosmid and shares 74.3%25 identity%2C in 378 aa overlap%2C with the downstream gene%2C SCF41.17. Note the predicted protein product of SCF41.06 is 36 aa longer than that of SCF41.17 gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0347 SCO0348 SCO0348 SCF41.07 SCF41.07 352776 353795 + 2-hydroxyacid dehydrogenase SCF41.07%2C possible 2-hydroxyacid-family dehydrogenase%2C len: 339 aa. Similar to Mycobacterium leprae SW:SERA_MYCLE (EMBL%3B Z99263) D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (PGDH) MLCB637.25 (528 aa)%2C fasta scores opt: 452 z-score: 525.4 E(): 6.5e-22 36.7%25 identity in 286 aa overlap and Pyrococcus abyssi TR:CAB49675 (EMBL%3B AJ248285) SERA-like protein (307 aa)%2C fasta scores opt: 437 z-score: 511.6 E(): 3.8e-21 32.0%25 identity in 309 aa overlap. Contains a Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0348 SCO0349 SCO0349 SCF41.08 SCF41.08 353801 354805 + oxidoreductase SCF41.08%2C possible oxidoreductase (hypothetical protein)%2C len: 334 aa. Similar to Pseudomonas sp. TR:Q52472 (EMBL%3B D32042) L-fucose dehydrogenase (329 aa)%2C fasta scores opt: 960 z-score: 1078.8 E(): 0 48.4%25 identity in 318 aa overlap gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0349 SCO0350 SCO0350 SCF41.09 SCF41.09 354802 355686 + hypothetical protein SCF41.09%2C unknown%2C len: 334 aa. Similar to several hypotheticals including: Rhizobium sp. SW:Y4MH_RHISN (EMBL%3B AE000085) hypothetical 33.9 KD protein Y4MH (297 aa)%2C fasta scores opt: 262 z-score: 309.5 E(): 6.9e-10 23.8%25 identity in 303 aa overlap gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0350 SCO0351 SCO0351 SCF41.10 SCF41.10 355683 357158 + hypothetical protein SCF41.10%2C unknown%2C len: 491 aa. gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0351 SCO0352 SCO0352 SCF41.11 SCF41.11 357209 358477 + solute-binding protein SCF41.11 possible solute-binding protein%2C len: 422 aa. Similar to many including: Streptomyces lividans TR:Q9Z492 (EMBL%3B AF043654) BxlE precursor (434 aa)%2C fasta scores opt: 287 z-score: 311.3 E(): 5.5e-10 25.7%25 identity in 354 aa overlap. Contains a PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0352 SCO0353 SCO0353 SCF41.12 SCF41.12 358481 359392 + binding protein dependent transport protein SCF41.12%2C possible binding-protein-dependent transport protein%2C len: 303 aa. Similar to many including: Streptomyces coelicolor TR:CAB41203 (EMBL%3B AL049661) binding protein dependent transport protein SCE134.05c (327 aa)%2C fasta scores opt: 560 z-score: 661.2 E(): 1.8e-29 35.5%25 identity in 301 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains multiple potential membrane-spanning hydrophobic domains. gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0353 SCO0354 SCO0354 SCF41.13 SCF41.13 359389 360231 + binding-protein-dependent transport protein SCF41.13%2C possible binding-protein-dependent transport protein%2C len: 280 aa%2C Similar to many e.g. Streptomyces coelicolor TR:O50501 (EMBL%3B AL009199) probable transmembrane transport protein SC7b7.04 (302 aa)%2C fasta scores opt: 584 z-score: 670.3 E(): 5.5e-30 36.1%25 identity in 274 aa overlap. Contains multiple membrane spanning hydrophobic domains%2C a PS00402 Binding-protein-dependent transport systems inner membrane comp sign and a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0354 SCO0355 SCO0355 SCF41.14 SCF41.14 360305 360646 + hypothetical protein SCF41.14%2C unknown%2C len: 113 aa. Shares a low level of similarity with Bacillus subtilis TR:O05263 (EMBL%3B Z93938) hypothetical 12.6 KD protein (104 aa)%2C fasta scores opt: 129 z-score: 179.4 E(): 0.012 31.3%25 identity in 96 aa overlap. gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0355 SCO0356 SCO0356 SCF41.15 SCF41.15 360674 361465 + oxidoreductase SCF41.15%2C probable oxidoreductase%2C len: 263 aa. Shares a high level of sequence similarity with Comamonas testosteroni TR:P94681 (EMBL:U32622) toluenesulfonate zinc-independent alcohol dehydrogenase (252 aa)%2C fasta scores opt: 506 z-score: 549.4 E(): 3e-23 39.8%25 identity in 244 aa overlap and Streptomyces coelicolor TR:O88068 (EMBL:AL031541) dehydrogenase SCI35.33C (260 aa)%2C fasta scores opt: 500 z-score: 542.8 E(): 7e-23 36.4%25 identity in 253 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase%2C Pfam match to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and a PS00061 Short-chain dehydrogenases/reductases family signature gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0356 SCO0357 SCO0357 SCF41.16c SCF41.16c 361759 362478 - GntR family transcriptional regulator SCF41.16c%2C probable GntR-family regulator ( hypothetical protein)%2C len: 270 aa. Similar to Streptomyces coelicolor TR:CAB50881 (EMBL%3B AL096844) GntR-family transcriptional regulator SCI28.07 (230 aa)%2C fasta scores opt: 292 z-score: 343.8 E(): 8.5e-12 32.7%25 identity in 220 aa overlap and Escherichia coli SW:PDHR_ECOLI (EMBL%3B V01498) pyruvate dehydrogenase complex repressor(254 aa)%2C fasta scores opt: 253 z-score: 298.6 E(): 2.8e-09 30.4%25 identity in 224 aa overlap. Contains a Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0357 SCO0358 SCO0358 SCF41.17 SCF41.17 362635 363777 + racemase SCF41.17%2C possible racemase%2C len: 380 aa. Duplication of SCF41.06. Similar to Pseudomonas putida SW:MANR_PSEPU (EMBL%3B M19043) mandelate racemase (EC 5.1.2.2) (359 aa)%2C fasta scores opt: 374 z-score: 431.2 E(): 1.2e-16 29.8%25 identity in 362 aa overlap. Contains a Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family. This gene is duplicated on this cosmid and shares 74.3%25 identity%2C in 378 aa overlap%2C with the upstream gene%2C SCF41.06 gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0358 SCO0359 SCO0359 SCF41.18 SCF41.18 363774 364496 + hypothetical protein SCF41.18%2C hypothetical protein%2C len: 240 aa%3B similar to TR:Q9KEZ0 (EMBL:AP001509) Bacillus halodurans BH0709 protein%2C 242 aa%3B fasta scores: opt: 515 Z-score: 603.7 E(): 5.4e-26%3B 36.000%25 identity in 225 aa overlap gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0359 SCO0360 SCO0360 SCF41.19c SCF41.19c 364559 365551 - LacI family DNA-binding transcriptional repressor SCF41.19c%2C probable DNA-binding%2C LacI family%2C regulator. len: 330 aa. Similar to Escherichia coli SW:GNTR_ECOLI (EMBL:D84362) gluconate utilization system GNT-I transcriptional repressor (331 aa)%2C fasta scores opt: 674 z-score: 767.8 E(): 0 36.9%25 identity in 320 aa overlap. Contains a PS00356 Bacterial regulatory proteins%2C lacI family signature%2C a PS00237 G-protein coupled receptors signature%2C Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and a Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C LacI family. Contains a possible helix-turn-helix motif between residues 2..23 score (+5.90 SD). gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0360 SCO0361 SCO0361 SCF41.20c SCF41.20c 365623 366795 - hypothetical protein SCF41.20c%2C unknown%2C len: 390 aa. Highly similar%2C over available sequence%2C to Caulobacter crescentus TR: Q46022 (EMBL%3B X98879) xylX gene (fragment) (>140 aa)%2C fasta scores opt: 276 z-score: 326.5 E(): 7.8e-11 50.0%25 identity in 122 aa overlap. gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0361 SCO0362 SCO0362 SCF41.21 SCF41.21 366935 368146 + racemase SCF41.21%2C possible racemase%2C len: 403 aa. Weakly similar to Eukaryotic and Prokaryotic racemases e.g. Homo sapiens (Human) TR:O43673 (EMBL%3B AF047020) alpha-methylacyl-CoA racemase (EC 5.1.99.4) (382 aa)%2C fasta scores opt: 466 z-score: 544.7 E(): 5.5e-23 31.1%25 identity in 392 aa overlap and Streptomyces coelicolor TR:CAB40680 (EMBL%3B AL049587) racemase SC5F2A.13 (398 aa)%2C fasta scores opt: 508 z-score: 593.2 E(): 1.1e-25 34.5%25 identity in 383 aa overlap gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0362 SCO0363 SCO0363 SCF41.22 SCF41.22 368143 369252 + hypothetical protein SCF41.22%2C possible integral membrane protein%2C len: 369 aa. Contains possible membrane spanning hydrophobic domains. gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0363 SCO0364 SCO0364 SCF41.23 SCF41.23 369249 370055 + enoyl-CoA hydratase SCF41.23%2C possible enoyl-CoA hydratase%2C len: 268 aa. Shares a high level of similarity with Mycobacterium tuberculosis TR:O53418 (EMBL%3B AL021897) enoyl-CoA hydratase MTV017.23C (EMBL%3B AL021897)%2C fasta scores opt: 554 z-score: 635.0 E(): 5.1e-28 40.9%25 identity in 257 aa overlap. Contains a Pfam match to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0364 SCO0365 SCO0365 SCF41.24 SCF41.24 370066 370812 + oxidoreductase SCF41.24%2C probable oxidoreductase (hypothetical protein)%2C len: 248 aa. Similar to Rhizobium sp. (strain NGR234) SW:Y4LA_RHISN (EMBL%3B AE000082) short-chain type dehydrogenase/reductase Y4LA (EC 1.-.-.-)%2C fasta scores opt: 487 z-score: 537.0 E(): 1.5e-22 38.8%25 identity in 245 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase%2C Pfam match to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and a PS00061 Short-chain dehydrogenases/reductases family signature gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0365 SCO0366 SCO0366 SCF41.25 SCF41.25 370809 371876 + hypothetical protein SCF41.25%2C hypothetical protein%2C len: 355 aa%3B similar to the plasmid borne TR:Q9R6D3 (EMBL:AB016260) Agrobacterium radiobacter TIORF127 protein%2C 361 aa%3B fasta scores: opt: 520 Z-score: 612.2 E(): 1.8e-26%3B 34.295%25 identity in 312 aa overlap gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0366 SCO0367 SCO0367 SCF41.26 SCF41.26 371921 372478 - hypothetical protein SCF41.26%2C membrane protein%2C len: 185 aa. A low level of similarity to Streptomyces coelicolor TR:O54175 (EMBL%3B AL021411) hypothetical 24.6 KD protein SC7H1.16 (257 aa)%2C fasta scores opt: 190 z-score: 226.1 E(): 3.1e-05 35.1%25 identity in 188 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0367 SCO0368 SCO0368 SCF41.27 SCF41.27 373045 374001 + transposase SCF41.27%2C transposase%2C len: 318 aa. Almost identical to several Streptomyces coelicolor transposases: TR:O86758 (EMBL%3B AL031035) transposase SC6A9.26 (318 aa)%2C fasta scores opt: 2214 z-score: 2579.1 E(): 0 99.7%25 identity in 318 aa overlap and TR:CAB52905 (EMBL%3B AL109949) insertion element transposase SCJ11.20 (318 aa)%2C fasta scores opt: 2214 z-score: 2571.8 E():0 99.7%25 identity in 318 aa overlap. Contains a possible helix-turn-helix motif between residues 26..47 scores (+3.19 SD). gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0368 SCO0369 SCO0369 SCF41.28c SCF41.28c 373998 377255 - hypothetical protein SCF41.28c%2C hypothetical protein%2C len: 1085 aa. Contains a possible N-terminal signal peptide sequence gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0369 SCO0370 SCO0370 SCF41.29c SCF41.29c 377286 380690 - DNA-binding protein SCF41.29c%2C possible DNA-binding protein ( hypothetical protein)%2C len: 1134 aa. Contains a possible N-terminal signal peptide sequence and a possible helix-turn-helix motif between residues 51..72 scores (+3.60 SD) gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0370 SCO0371 SCO0371 SCF41.30c SCF41.30c 380751 383360 - hypothetical protein SCF41.30c%2C possible hypothetical protein%2C len: 900 aa. Shares a low level of similarity%2C over the available sequence%2C with Bacteroides ovatus TR:Q45327 (EMBL%3B U15179) arabinosidase (ASDII) (fragment) (>436 aa)%2C fasta scores opt: 323 z-score: 317.9 E(): 2.4e-10 30.6%25 identity in 304 aa overlap. Contains a possible N-terminal signal sequence. gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0371 SCO0372 SCO0372 SCF41.31c SCF41.31c 383578 386592 - hypothetical protein SCF41.31c%2C possible hypothetical protein%2C len: 1024 aa. Contains a possible N-terminal signal sequence. gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0372 SCO0373 SCO0373 SCF41.32c SCF41.32c 386761 387360 - hypothetical protein SCF41.32c%2C possible hypothetical protein%2C len: 199 aa. Contains a possible N-terminal signal sequence. gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0373 SCO0374 SCO0374 SCF41.33 SCF41.33 387750 389519 + ABC transporter SCF41.33%2C ABC transporter%2C len: 589 aa. Similar to many e.g. Streptomyces coelicolor TR:Q9ZNB0 (EMBL%3B AB019513) ABC transporter (584 aa)%2C fasta scores opt: 597 z-score: 649.7 E(): 7.7e-29 30.9%25 identity in 572 aa overlap. Contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter and a PS00017 ATP/GTP-binding site motif A (P-loop). Contains membrane-spanning hydrophobic domains. gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0374 SCO0375 SCO0375 SCF41.34c SCF41.34c 389531 391123 - integral membrane transport protein SCF62.01c%2C possible integral membrane transport protein%2C partial CDS%2C len: > 406 aa. Similar to many members of the drug resistance translocase family e.g. Staphylococcus aureus SW:QACA_STAAU (EMBL%3B X56628) antiseptic resistance protein (514 aa)%2C fasta scores opt: 750 z-score: 750.4 E():0 30.0%25 identity in 493 aa overlap%2C as well as many other Streptomyces coelicolor membrane transport proteins e.g. TR:O54186 (EMBL%3B AL021411) SC7H1.27 (533 aa)%2C fasta scores opt: 972 z-score: 970.2 E(): 0 35.0%25 identity in 543 aa overlap. Overlaps with and extends into SCF41.34c. Contains multiple possible membrane spanning hydrophobic domains and a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter.~SCF41.34c%2C possible transport protein%2C partial CDS%2C len: >157 aa. Similar to Streptomyces coelicolor transport protein TR:O54186 (EMBL%3B AL021411) transport protein SC7H1.27 (533 aa)%2C fasta scores opt: 263 z-score: 281.1 E(): 2.6e-08 36.1%25 identity in 166 aa overlap. gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0375 SCO0376 SCO0376 SCF62.02 SCF62.02 391232 391834 + transcriptional regulator SCF62.02%2C possible transcriptional regulator%2C len: 200 aa. Similar to several proteins of undefined function from Streptomyces sp. e.g. Streptomyces coelicolor TR:CAB51134 (EMBL%3B Y18817) hypothetical 20.6 KD protein (190 aa)%2C fasta scores opt: 352 z-score: 424.9 E(): 2.6e-16 37.0%25 identity in 189 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix between residues 29..50 (+5.17 SD). gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0376 SCO0377 SCO0377 SCF62.03c SCF62.03c 391950 392483 - hypothetical protein SCF62.03c%2C possible integral membrane protein%2C len: 177 aa. Contains multiple possible membrane spanning hydrophobic domains. gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0377 SCO0378 SCO0378 SCF62.04c SCF62.04c 392484 393218 - hypothetical protein SCF62.04c%2C possible hypothetical protein%2C len: 244 aa. Highly similar to Streptomyces coelicolor TR:CAB52958 (EMBL%3B AL109950) hypothetical 25.2 KD protein SCJ4.24C (242 aa)%2C fasta scores opt: 1283 z-score: 1457.6 E(): 0 83.1%25 identity in 242 aa overlap. Contains a possible N-terminal signal sequence. gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0378 SCO0379 SCO0379 katA katA 393498 394961 + catalase SCF62.05%2C katA%2C catalase (EC 1.11.1.6) len: 487 aa. Has been previously sequenced and characterised from Streptomyces coelicolor strain ATCC10147 TR:P77948 (EMBL%3B X96981) catalase (EC 1.11.1.6) (488 aa)%2C fasta scores opt: 3300 z-score: 3768.6 E():0 98.2%25 identity in 488 aa overlap. Also similar to another proposed Streptomyces coelicolor catalase (EC 1.11.1.6) TR:Q9Z598 (EMBL%3B AL035478) SC2G5.25C (487 aa)%2C fasta scores opt: 1704 z-score: 1896.1 E():0 53.8%25 identity in 483 aa overlap. Contains Prosite hits to PS00437 Catalase proximal heme-ligand signature and to PS00438 Catalase proximal active site signature. Also contains a Pfam match to entry PF00199 catalase%2C Catalase. gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0379 SCO0380 SCO0380 SCF62.06 SCF62.06 395065 395460 + hypothetical protein SCF62.06%2C unknown%2C len: 131 aa. Weakly similar to several Prokaryotic Ank-like proteins e.g. Pseudomonas syringae TR:P95546 (EMBL%3B AF001355) AnkF precursor (183 aa)%2C fasta scores opt: 255 z-score: 318.0 E(): 2.3e-10 38.4%25 identity in 125 aa overlap. Contains 2x Pfam match to entry PF00023 ank%2C Ank repeat. gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0380 SCO0381 SCO0381 SCF62.07 SCF62.07 395939 397414 + glycosyl transferase gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0381 SCO0382 SCO0382 SCF62.08 SCF62.08 397485 398810 + UDP-glucose/GDP-mannose dehydrogenase SCF62.08%2C probable UDP-glucose/GDP-mannose dehydrogenase (hypothetical protein)%2C len: 441 aa. Highly similar to many e.g. Pseudomonas syringae (pv. phaseolicola) SW: ALGD_PSESH (EMBL%3B AF001555) GDP-mannose 6-dehydrogenase (EC 1.1.1.132) (438 aa)%2C fasta scores opt: 1453 z-score: 1666.9 E(): 0 49.2%25 identity in 445 aa overlap. Contains a Pfam match to entry PF00984 UDPG_MGDP_dh%2C UDP-glucose/GDP-mannose dehydrogenase family. gene gene368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0382 SCO0383 SCO0383 SCF62.09 SCF62.09 398881 400104 + hypothetical protein SCF62.09%2C unknown%2C len: 407 aa. Weakly similar to a number of glycosyl transferases e.g. Streptomyces coelicolor TR:CAB39859 (EMBL%3B AL049497) glycosyl transferase SC6G10.05C (412 aa)%2C fasta scores opt: 236 z-score: 280.6 E(): 2.8e-08 26.4%25 identity in 386 aa overlap and Escherichia coli TR:Q47594 (EMBL%3B D43637) mannosyltransferase B (381 aa)%2C fasta scores opt: 187 z-score: 223.4 E(): 4.3e-05 23.3%25 identity in 288 aa overlap. Contains a TTA leucine codon%2C possible target for bldA regulation. gene gene369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0383 SCO0384 SCO0384 SCF62.10 SCF62.10 400179 401468 + hypothetical protein SCF62.10%2C possible membrane protein%2C len: 429 aa. Contains a possible membrane spanning hydrophobic domain and a probable coiled-coil from 146 to 176 (31 residues). gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0384 SCO0385 SCO0385 SCF62.11 SCF62.11 401465 403030 + hypothetical protein SCF62.11%2C possible membrane protein%2C len: 521 aa. Contains possible membrane spanning hydrophobic domains and two possible coiled-coils from 144 to 182 (39 residues) and from 190 to 221 (32 residues). gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0385 SCO0386 SCO0386 SCF62.12 SCF62.12 403034 404968 + asparagine synthetase SCF62.12%2C asparagine synthetase%2C len: 644 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:ASNH_MYCTU (EMBL%3B Z70283) asparagine synthetase (glutamine-hydrolysing) (EC 6.3.5.4) (652 aa)%2C fasta scores opt: 752 z-score: 874.8 E():0 32.8%25 identity in 655 aa overlap. Contains a Pfam match to entry PF00310 GATase_2%2C Glutamine amidotransferases class-II. gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0386 SCO0387 SCO0387 SCF62.13 SCF62.13 405070 407250 + bi-domain-containing oxidoreductase SCF62.13. possible bi-domain oxidoreductase%2C len: 726 aa. The N-terminus is similar to many Zinc-binding dehydrogenases e.g. Sinorhizobium meliloti TR:O31186 (EMBL%3B AF031940) alcohol dehydrogenase (340 aa)%2C fasta scores pt: 224 z-score: 241.8 E(): 4.1e-06 25.5%25 identity in 333 aa overlap. The C-terminus is similar to other oxidoreductases e.g. Zymomonas mobilis SW:GFO_ZYMMO (EMBL%3B M97379) glucose-fructose oxidoreductase precursor (EC 1.1.99.28) (439 aa)%2C fasta scores opt: 243 z-score: 260.3 E(): 3.8e-07 26.1%25 identity in 272 aa overlap. Note this CDS is also weakly similar to the C-terminus of the Eukaryotic: Cochliobolus heterostrophus TR:Q92217 (EMBL%3B U68040) polyketide synthase (2530 aa)%2C fasta scores opt: 164 z-score:0.0 E(): 0.0 25.52%25 identity in 576 aa overlap. Contains a Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. Also contains possible membrane spanning hydrophobic domains gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0387 SCO0388 SCO0388 SCF62.14 SCF62.14 407253 409214 + hypothetical protein SCF62.14%2C unknown%2C len: 653 aa. Weakly similar to Cytophaga heparina TR: Q59289 (EMBL%3B U27586) heparinase III protein precursor (EC 4.2.2.8) (659 aa)%2C fasta scores opt: 202 z-score: 229.2 E(): 2.1e-05 22.8%25 identity in 421 aa overlap. gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0388 SCO0389 SCO0389 SCF62.15 SCF62.15 409237 410772 + lipoprotein SCF62.15%2C possible lipoprotein%2C len: 511 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0389 SCO0390 SCO0390 SCF62.16 SCF62.16 410774 412006 + hypothetical protein SCF62.16%2C possible membrane protein%2C len: 410 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0390 SCO0391 SCO0391 SCF62.17 SCF62.17 412009 413250 + transferase SCF62.17%2C possible transferase%2C len: 413 aa. Similar to many including Streptomyces coelicolor TR:Q9Z5B7 (EMBL:AL035478) transferase SC2G5.06 (406 aa)%2C fasta scores opt: 263 z-score: 301.1 E(): 2.1e-09 31.9%25 identity in 385 aa overlap and Erwinia amylovora SW:AMSK_ERWAM (EMBL:X77921) amylovoran biosynthesis protein AmsK (407 aa)%2C fasta scores opt: 224 z-score: 257.0 E(): 5.8e-07 28.4%25 identity in 232 aa overlap. Contains a Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0391 SCO0392 SCO0392 SCF62.18 SCF62.18 413247 414497 + methyltransferase SCF62.18%2C possible methyltransferase%2C len: 416 aa. Similar to several including: Streptomyces peucetius TR:O68501 (EMBL%3B AF048833) daunorubicin/doxorubicin biosynthesis enzyme DnrX (403 aa)%2C fasta scores opt: 801 z-score: 923.6 E(): 0%3B 36.7%25 identity in 403 aa overlap and Streptomyces fradiae TR:AAD41823 (EMBL:AF147704) NDP-hexose 3-C-methyltransferase TYLCIII (418 aa)%2C fasta scores opt: 688 z-score: 793.6 E(): 0%3B 34.1%25 identity in 425 aa overlap gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0392 SCO0393 SCO0393 SCF62.19 SCF62.19 414494 415303 + transferase SCF62.19%2C possible transferase%2C len: 269 aa. Similar to many transferases e.g. Streptomyces glaucescens TR:Q54266 (EMBL:X82177) alpha-D-glucose-1-phosphate cytidylyl-transferase StrQ (fragment) (299 aa)%2C fasta scores opt: 554 z-score: 687.3 E(): 6.3e-31 35.0%25 identity in 280 aa overlap. gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0393 SCO0394 SCO0394 SCF62.20 SCF62.20 415300 415947 + hypothetical protein SCF62.20%2C unknown%2C len: 215 aa gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0394 SCO0395 SCO0395 SCF62.21 SCF62.21 415951 416976 + epimerase/dehydratase SCF62.21%2C possible epimerase/dehydratase%2C len: 314 aa. Highly similar to Streptomyces glaucescens TR:Q54262 (EMBL:X78974) protein involved in biosynthesis of 5'-hydroxystreptomycin StrP (358 aa)%2C fasta scores opt: 1446 z-score: 1656.6 E(): 0 68.4%25 identity in 342 aa overlap. Also similar to Streptomyces griseus SW:STRE_STRGR (EMBL:X62567) DTDP-glucose 4%2C6-dehydratase (EC 4.2.1.46) (328 aa)%2C fasta scores opt: 260 z-score: 303.2 E(): 1.6e-09 28.4%25 identity in 317 aa overlap. Contains a Pfam match to entry PF01370 Epimerase%2C NAD dependent epimerase/dehydratase family gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0395 SCO0396 SCO0396 SCF62.22 SCF62.22 416973 418247 + hypothetical protein SCF62.22%2C unknown%2C len: 424 aa gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0396 SCO0397 SCO0397 SCF62.23 SCF62.23 418253 419542 + hypothetical protein SCF62.23%2C possible integral membrane protein%2C len:429 aa. Weakly similar to several proteins of undefined function e.g. Synechocystis sp. (strain PCC 6803) TR:P72591 (EMBL%3B D90899) iron(III) dicitrate transport system permease FecD (349 aa)%2C fasta scores opt: 154 z-score: 170.4 E(): 0.039 25.4%25 identity in 334 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0397 SCO0398 SCO0398 SCF62.24 SCF62.24 419539 420486 + glycosyl transferase SCF62.24%2C possible glycosyl transferase%2C len: 315 aa. Similar to several e.g. Rickettsia prowazekii TR:Q9ZD96 (EMBL:AJ235271) glycosyl transferase (280 aa)%2C fasta scores opt: 272 z-score: 326.2 E(): 8.1e-11 29.9%25 identity in 214 aa overlap and Neisseria gonorrhoeae TR:Q50949 (EMBL:U14554) glycosyl transferase (337 aa)%2C fasta scores opt: 234 z-score: 280.4 E(): 2.9e-08 27.8%25 identity in 248 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0398 SCO0399 SCO0399 SCF62.25 SCF62.25 420492 421715 + hypothetical protein SCF62.25%2C possible membrane protein%2C len: 407 aa. Weakly similar to a several e.g. Erwinia amylovora SW: AMSJ_ERWAM (EMBL%3B X77921) amylovoran biosynthesis protein AmsJ (415 aa)%2C fasta scores opt: 107 z-score: 129.1 E(): 7.8 21.3%25 identity in 423 aa overlap and Escherichia coli SW:WCAK_ECOLI (EMBL%3B U38473) colanic acid biosynthesis protein WcaK (426 aa)%2C fasta scores opt: 111 z-score: 133.6 E():4.3 20.1%25 identity in 398 aa overlap. Contains a possible N-terminal signal sequence and a membrane spanning hydrophobic domain. Also contains a TTA leucine codon%2C possible target for bldA regulation and a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0399 SCO0400 SCO0400 SCF62.26 SCF62.26 421712 422263 + epimerase SCF62.26%2C possible epimerase%2C len: 178 aa. Similar to many including: Streptomyces griseus SW:STRM_STRGR (EMBL%3B X62567) dTDP-4-dehydrorhamnose 3%2C5-epimerase (EC 5.1.3.13) (DTDP-4-keto-6-deoxyglucose 3%2C5-epimerase) (DTDP-l-rhamnose synthetase) (200 aa)%2C fasta scores opt: 340 z-score:0.0 E(): 0.0 37.78%25 identity in 180 aa overlap and Leptospira borgpetersenii TR:Q9ZGK0 (EMBL%3B AF078135) RmlC (186 aa)%2C fasta scores pt: 432 z-score: 524.9 E(): 7.2e-22 42.3%25 identity in 175 aa overlap. Contains a Pfam match to entry PF00908 dTDP_sugar_isom%2C dTDP-4-dehydrorhamnose 3%2C5-epimerase. gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0400 SCO0401 SCO0401 SCF62.27 SCF62.27 422271 423596 + glutamate-1-semialdehyde 2%2C1-aminomutase catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0401 SCO0402 SCO0402 SCF51.01c SCF51.01c 423654 424406 - hypothetical protein SCF51.01c%2C unknown%2C len: >48 aa~SCF62.28c%2C possible integral membrane protein%2C partial CDS%2C len: >248 aa. Weakly similar in parts to Streptomyces coelicolor TR:O86624 (EMBL: AL031155) integral membrane protein SC3A7.23C (272 aa)%2C fasta scores opt: 189 z-score: 228.1 E(): 2.5e-05 31.6%25 identity in 190 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0402 SCO0403 SCO0403 SCF51.02c SCF51.02c 424609 425226 - hypothetical protein SCF51.02c%2C hypothetical protein%2C len: 187 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB56690 (EMBL:AL121596) Streptomyces coelicolor SCF51A.38 hypothetical 18.5 KD protein%2C 169 aa%3B fasta scores: opt: 176 z-score: 225.6 E(): 3.4e-05%3B 32.9%25 identity in 173 aa overlap gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0403 SCO0404 SCO0404 SCF51.03 SCF51.03 425243 425983 + 2-haloalkanoic acid dehalogenase SCF51.03%2C possible 2-haloalkanoic acid dehalogenase%2C len: 246 aa%3B similar to SW:HAD2_PSEPU (EMBL:D17523) Pseudomonas putida 2-haloalkanoic acid dehalogenase H-109 (EC 3.8.1.2) (L-2-haloacid dehalogenase H-109) (halocarboxylic acid halidohydrolase H-109) DehH109%2C 224 aa: fasta scores: opt: 275 z-score: 328.4 E(): 6.4e-11%3B 32.2%25 identity in 202 aa overlap. Contains a Pfam match to entry PF00702 hydrolase%2C haloacid dehalogenase-like hydrolase gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0404 SCO0405 SCO0405 SCF51.04c SCF51.04c 426015 426833 - hypothetical protein SCF51.04%2C conserved hypothetical protein%2C len: 272 aa%3B similar to TR:O86540 (EMBL:AL031350) Streptomyces coelicolor hypothetical 32.8 kD protein%2C 300 aa%3B fasta scores: opt: 656 z-score: 793.0 E(): 0%3B 43.1%25 identity in 246 aa overlap gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0405 SCO0406 SCO0406 SCF51.05 SCF51.05 426893 427606 + hypothetical protein SCF51.05%2C unknown%2C len: 237 aa gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0406 SCO0407 SCO0407 SCF51.06 SCF51.06 427610 428614 + transcriptional regulator SCF51.06%2C possible transcriptional regulator%2C len: 334 aa%3B similar to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA%2C 253 aa%3B fasta scores: opt: 215 z-score: 237.9 E(): 7e-06%3B 37.9%25 identity in 103 aa overlap and to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor transcriptional regulator SC7H1.32c%2C len: 196 aa%3B fasta scores: opt: 264 z-score: 290.9 E(): 7.8e-09%3B 37.4%25 identity in 139 aa overlap. Contains a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and a prosite match to entry PS00552 Bacterial regulatory proteins%2C merR family signature. Contains possible helix-turn-helix motif between residues 3351..3416%2C score 1170 (+3.17 SD) gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0407 SCO0408 SCO0408 SCF51.07 SCF51.07 428615 429403 + methyltransferase SCF51.07%2C probable methyltransferase%2C len: 262 aa%3B some similarity to TR:Q9ZGH6 (EMBL:AF079762) Streptomyces venezuelae N%2CN-dimethyltransferase DesVI 273 aa%3B fasta scores: opt: 165 z-score: 205.9 E(): 0.00043%3B 28.3%25 identity in 237 aa overlap and to TR:CAB49808 (EMBL:AJ248285) Pyrococcus abyssi menaquinone biosynthesis methyltransferase%2C 248 aa%3B fasta scores: opt: 165 z-score: 205.6 E(): 0.00044%3B 27.3%25 identity in 183 aa overlap gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0408 SCO0409 SCO0409 sapA sapA 429492 429956 - spore-associated protein SCF51.08c%2C sapA spore-associated protein precursor%2C len: 154 aa%3B N-terminal region identical to SW:SAPA_STRCO (EMBL:M20145) Streptomyces coelicolor spore-associated protein precursor (fragment) SapA%2C 120 aa gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0409 SCO0410 SCO0410 SCF51.09c SCF51.09c 430071 431321 - hypothetical protein SCF51.09c%2C hypothetical protein%2C len: 416 aa%3B similar to TR:Q49897 (EMBL:U00021) Mycobacterium leprae hypothetical protein MLC1351.13c%2C 311 aa%3B fasta scores: opt: 288 z-score: 317.7 E(): 2.5e-10%3B 34.4%25 identity in 326 aa overlap. Contains Pfam match to entry PF01513 DUF15%2C domain of unknown function and prosite PS00339 aminoacyl-transfer RNA synthetases class-II signature 2 gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0410 SCO0411 SCO0411 SCF51.10 SCF51.10 431327 431551 + hypothetical protein SCF51.10%2C unknown%2C len: 74 aa. Contains a prosite match to entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0411 SCO0412 SCO0412 SCF51.11 SCF51.11 431551 431934 + hypothetical protein SCF51.11%2C unknown%2C len: 127 aa gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0412 SCO0413 SCO0413 SCF51.12c SCF51.12c 431962 432564 - hypothetical protein SCF51.12c%2C unknown%2C len: 200 aa. gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0413 SCO0414 SCO0414 SCF51.13c SCF51.13c 432617 433513 - RNA polymerase sigma factor SCF51.13c%2C possible RNA polymerase sigma factor%2C len: 298 aa%3B similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor RNA polymerase sigma factor SCH10.4c%2C 294aa%3B fasta scores: opt: 614 z-score: 721.0 E(): 8.7e-33%3B 41.4%25 identity in 285 aa overlap and to TR:O86856 (EMBL:AJ007313) Streptomyces coelicolor sigma factor%2C SigT%2C 236aa%3B fasta scores: opt: 160 z-score: 194.6 E(): 0.0018%3B 31.0%25 identity in 158 aa overlap gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0414 SCO0415 SCO0415 SCF51.14 SCF51.14 433615 433977 + hypothetical protein SCF51.14%2C possible integral membrane protein%2C len: 120 aa. Contains possible hydrophobic membrane spanning regions gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0415 SCO0416 SCO0416 SCF51.15c SCF51.15c 433984 434589 - hypothetical protein SCF51.15c%2C probable integral membrane protein%2C len: 201 aa%3B similarity to SW:CMLR_STRLI (EMBL:X59968) Streptomyces lividans chloramphenicol resistance protein%2C 392aa%3B fasta scores: opt: 123 z-score: 149.4 E(): 0.6%3B 30.5%25 identity in 177 aa overlap gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0416 SCO0417 SCO0417 SCF51.16c SCF51.16c 434651 435397 - hypothetical protein SCF51.16c%2C hypothetical protein%2C len: 248 aa%3B similar to TR:P74164 (EMBL:D90912) Synechocystis sp. (strain PCC 6803) hypothetical 33.9 KD protein%2C 300 aa%3B fasta scores: opt: 361 z-score: 423.5 E(): 3.2e-16%3B 35.9%25 identity in 259 aa overlap gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0417 SCO0418 SCO0418 SCF51.17 SCF51.17 435456 436103 + DNA-binding protein SCF51.17%2C DNA-binding protein%2C len: 215 aa%3B similar to TR:CAB44405 (EMBL:AL078610) Streptomyces coelicolor DNA-binding protein%2C SCH35.22c 215 aa%3B fasta scores: opt: 206 z-score: 233.8 E(): 1.2e-05%3B 30.9%25 identity in 220 aa overlap and to TR:CAB45035 (EMBL:AL078635) Amycolatopsis orientalis hypothetical protein CZA382.14c%2C 202 aa%3B fasta scores: opt: 305 z-score: 340.6 E(): 1.3e-11%3B 34.0%25 identity in 212 aa overlap gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0418 SCO0419 SCO0419 SCF51.18 SCF51.18 436235 437224 + zinc-binding oxidoreductase SCF51.18%2C possible zinc-binding oxidoreductase%2C len: 329 aa%3B similar to SW:QOR_PSEAE (EMBL:X85015) Pseudomonas aeruginosa quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) qor%2C 325 aa%3B fasta scores: opt: 420 z-score: 452.5 E(): 7.8e-18%3B 32.8%25 identity in 332 aa overlap and to TR:CAB45348 (EMBL:AL079345) Streptomyces coelicolor dehydrogenase SCE68.12c%2C 318 aa%3B fasta scores: opt: 535 z-score: 574.1 E(): 1.3e-24%3B 38.6%25 identity in 332 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0419 SCO0420 SCO0420 SCF51.19c SCF51.19c 437253 438287 - homoserine dehydrogenase SCF51.19c%2C possible homoserine dehydrogenase%2C len: 344 aa%3B similar to SW:DHOM_SYNY3 (EMBL:D64001) Synechocystis sp. (strain PCC 6803) homoserine dehydrogenase (EC 1.1.1.3) (HDH)%2C 433 aa%3B fasta scores: opt: 284 z-score: 307.6 E(): 9.2e-10%3B 29.0%25 identity in 335 aa overlap and to TR:O26517 (EMBL:AE000826) Methanobacterium thermoautotrophicum homoserine dehydrogenase homologue MTH417%2C 340 aa%3B fasta scores: opt: 332 z-score: 359.9 E(): 1.1e-12%3B 30.1%25 identity in 335 aa overlap. Contains Prosite match to entry PS01042 Homoserine dehydrogenase signature gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0420 SCO0421 SCO0421 SCF51.20c SCF51.20c 438329 438988 - two-component response regulator SCF51.20c%2C possible two-component response regulator%2C len: 219 aa%3B similar to TR:CAB51249 (EMBL:AL096872) Streptomyces coelicolor two-component response regulator%2C SC5F7.36c%2C 227 aa%3B fasta scores: opt: 815 z-score: 952.9 E(): 0%3B 61.8%25 identity in 220 aa overlap and to TR:Q53894 (EMBL:U51332) Streptomyces coelicolor absA2%2C 222 aa%3B fasta scores: opt: 543 z-score: 638.7 E(): 3.3e-28%3B 43.8%25 identity in 217 aa overlap. Contains two Pfam matches to entries PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and PF00072 response_reg%2C Response regulator receiver domain and Prosite match to entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible helix-turn-helix motif between residues 14157..14222%2C score 1198 (+3.27 SD) gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0421 SCO0422 SCO0422 SCF51.21c SCF51.21c 438997 440190 - two-component sensor kinase SCF51.21c%2C possible two-component sensor kinase%2C len: 397 aa%3B similar to TR:CAB51250 (EMBL:AL096872) Streptomyces coelicolor two-component sensor kinase%2C SC5F7.35c%2C 416 aa%3B fasta scores: opt: 841 z-score: 875.2 E(): 0%3B 43.5%25 identity in 393 aa overlap and to TR:Q53893 (EMBL:U51332) Streptomyces coelicolor AbsA1%2C571 aa%3B fasta scores: opt: 369 z-score: 385.9 E(): 4e-14%3B 30.5%25 identity in 394 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0422 SCO0423 SCO0423 SCF51A.01c SCF51A.01c 440282 442579 - membrane transport protein SCF51A.01c%2C membrane transport protein%2C len: 765 aa. Similar to many Streptomyces coelicolor integral membrane proteins including:TR:Q53902 (EMBL%3B M64683) ORF1-4 (ACTII) (711 aa)%2Cfasta scores opt: 291 z-score: 295.3 E(): 4.3e-09 27.7%25 identity in 779 aa overlap%2C TR:Q9Z577 (EMBL%3B AL035569) SC8D9.14 (748 aa)%2C fasta scores opt: 1021 z-score: 1028.4 E(): 0 40.6%25 identity in 773 aa overlap and TR:O88022 (EMBL%3B AL031107) SC5A7.16C (705 aa)%2C fasta scores opt: 639 z-score: 645.0 E(): 1.4e-28 37.2%25 identity in 764 aa overlap. Contains multiple possible transmembrane hydrophobic domains. gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0423 SCO0424 SCO0424 SCF51A.02 SCF51A.02 442700 443191 + hypothetical protein SCF51A.02%2C unknown%2C len: 168 aa. gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0424 SCO0425 SCO0425 SCF51A.03c SCF51A.03c 443293 444243 - hypothetical protein SCF51A.03c%2C unknown%2C len: 316 aa. Similar to Streptomyces coelicolor TR:CAB46385 (EMBL%3B AL096743) hypothetical 30.5 KD protein SCI7.02C (281 aa)%2C fasta scores opt: 424 z-score: 490.6 E(): 5.7e-20 36.6%25 identity in 292 aa overlap. gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0425 SCO0426 SCO0426 SCF51A.04 SCF51A.04 444441 444671 + hypothetical protein SCF51A.04%2C unknown%2C len: 76 aa. gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0426 SCO0427 SCO0427 SCF51A.05 SCF51A.05 444752 445588 + hydrolase SCF51A.05%2C possible hydrolase%2C len: 278 aa. Similar to many e.g. Pseudomonas fluorescens SW:PRXC_PSEFL (EMBL:AF031153) non-heme chloroperoxidase (EC 1.11.1.10) (chloride peroxidase)%2C fasta scores opt: 243 z-score: 282.1 E(): 2.4e-08 28.4%25 identity in 275 aa overlap and many hydrolases: Streptomyces coelicolor TR:CAB44393 (EMBL%3B AL078610) hydrolase SCH35.34C (269 aa)%2C fasta scores opt: 259 z-score: 300.1 E(): 2.3e-09 29.7%25 identity in 269 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0427 SCO0428 SCO0428 SCF51A.06 SCF51A.06 445611 446144 + tetR family transcriptional regulator SCF51A.06%2C possible tetR family transcriptional regulator%2C len: 177 aa. Similar to many regulators e.g. Streptomyces coelicolor TR:Q9ZBU4 (EMBL%3B AL034446) transcriptional regulator SC1A9.08C (189 aa)%2C fasta scores opt: 402 z-score: 476.9 E(): 3.3e-19 45.5%25 identity in 165 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif between residues 18..39 (+2.91 SD). gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0428 SCO0429 SCO0429 SCF51A.07c SCF51A.07c 446214 447161 - oxidoreductase SCF51A.07c%2C possible oxidoreductase%2C len: 315 aa. Weakly similar to many eukaryotic oxidoreductases e.g. Hordeum vulgare (Barley) TR:Q42837 (EMBL%3B Z48360) aldose reductase (EC 1.1.1.21) (aldehyde reductase) (320 aa)%2C fasta scores opt: 236 z-score: 263.3 E(): 2.6e-07 27.0%25 identity in 296 aa overlap and many other oxidoreductases e.g. Streptomyces coelicolor TR:CAB42953 (EMBL:AL049863) oxidoreductase SC5H1.28C (305 aa)%2C fasta scores opt: 563 z-score: 617.0 E(): 5.2e-27 39.7%25 identity in 305 aa overlap gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0429 SCO0430 SCO0430 SCF51A.08 SCF51A.08 447185 447868 + tetR family transcriptional regulator SCF51A.08%2C possible tetR family transcriptional regulator%2C len: 227 aa. Similar to several regulators e.g. Streptomyces coelicolor TR:CAB46405 (EMBL%3B AL096743) transcriptional regulator SCI7.22c (202 aa)%2C fasta scores opt: 428 z-score: 495.6 E(): 3e-20 41.1%25 identity in 202 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif between residues 71..92 (+3.86 SD). gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0430 SCO0431 SCO0431 SCF51A.09c SCF51A.09c 447890 449218 - hypothetical protein SCF51A.09c%2C possible hypothetical protein%2C len: 442 aa%3B similar to TR:Q9KZR1 (EMBL:AL353832) Streptomyces coelicolor hypothetical protein SCE6.29%2C 454 aa%3B fasta scores: opt: 614 Z-score: 655.9 E(): 6.7e-29%3B 31.278%25 identity in 454 aa overlap. Contains a possible N-terminal signal sequence gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0431 SCO0432 SCO0432 SCF51A.10 SCF51A.10 449515 453252 + peptidase SCF51A.10%2C probable peptidase%2C len: 1245 aa. Highly similar to Streptomyces albogriseolus TR:P95684 (EMBL%3B D83672) subtilisin-like protease (1102 aa)%2C fasta scores opt: 1572 z-score: 1550.1 E(): 0 34.4%25 identity in 1259 aa overlap. Also similar to the much smaller subtilisins e.g. Bacillus sp. (strain TA39) SW:SUBT_BACS9 (EMBL%3B X62369) subtilisin precursor (EC 3.4.21.62) (420 aa)%2C fasta scores opt: 485 z-score: 483.5 E(): 1.4e-19 38.2%25 identity in 304 aa overlap. Contains a Pfam match to entry PF00082 Peptidase_S8%2C Subtilase family and a possible N-terminal signal sequence. gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0432 SCO0433 SCO0433 SCF51A.11 SCF51A.11 453370 454374 + transcriptional regulator SCF51A.11%2C possible transcriptional regulator%2C len: 334 aa. Similar to Streptomyces coelicolor TR:Q9ZBT5 (EMBL%3B AL034446) regulatory protein SC1A9.17C (327 aa)%2C fasta scores opt: 494 z-score: 573.8 E(): 1.3e-24 36.9%25 identity in 333 aa overlap. Contains a possible helix-turn-helix motif between residues 290..311 (+2.71 SD). gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0433 SCO0434 SCO0434 malX malX 454546 456195 + bifunctional PTS system maltose and glucose-specific transporter subunits IICB phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%3B catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane%3B component IIB catalyzes the phosphorylation of the sugar molecule%3B IIC forms the translocation channel and contains the substrate specific binding site gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0434 SCO0435 SCO0435 malY malY 456192 457397 + aminotransferase SCF51A.13%2C malY%2C aminotransferase%2C len: 401 aa. Highly similar to Escherichia coli SW:MALY_ECOLI (EMBL%3B M60722) MalY protein (EC 2.6.1.-) (390 aa)%2C fasta scores opt: 1577 z-score: 1814.7 E():0 58.5%25 identity in 386 aa overlap gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0435 SCO0436 SCO0436 rpmF rpmF 457484 457654 + 50S ribosomal protein L32 some L32 proteins have zinc finger motifs consisting of CXXC while others do not gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0436 SCO0437 SCO0437 SCF51A.15c SCF51A.15c 457670 458695 - hypothetical protein SCF51A.15c%2C hypothetical protein%2C len: 341 aa%3B similar to TR:Q9A8Z7 (EMBL:AE005797) Caulobacter crescentus hypothetical protein CC1198%2C 331 aa%3B fasta scores: opt: 855 Z-score: 977.0 E(): 8.7e-47%3B 45.181%25 identity in 332 aa overlap gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0437 SCO0438 SCO0438 pcp pcp 458695 459345 - pyrrolidone-carboxylate peptidase SCF51A.16c%2C pcp%2C pyrrolidone-carboxylate peptidase (EC 3.4.19.3)%2C len: 216 aa. Highly similar to many e.g. Bacillus subtilis SW:PCP_BACSU (EMBL%3B X66034) pyrrolidone-carboxylate peptidase (EC 3.4.19.3) (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase)(215 aa)%2C fasta scores opt: 741 z-score: 820.9 E(): 0 52.3%25 identity in 214 aa overlap. Contains a Pfam match to entry PF01470 Peptidase_C15%2C Pyroglutamyl peptidase and a Prosite hit to PS01334 Pyrrolidone-carboxylate peptidase cysteine active site gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0438 SCO0439 SCO0439 SCF51A.17c SCF51A.17c 459393 460367 - hypothetical protein SCF51A.17c%2C possible membrane protein%2C len: 324 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0439 SCO0440 SCO0440 SCF51A.18c SCF51A.18c 460364 461083 - hypothetical protein SCF51A.18c%2C possible integral membrane protein%2C len: 239 aa. Contains multiple possible membrane spanning hydrophobic domains. gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0440 SCO0441 SCO0441 SCF51A.19 SCF51A.19 461350 462102 + LamB/YcsF family protein SCF51A.19%2C unknown%2C len: 250 aa. Similar to hypothetical proteins e.g. Bordetella pertussis TR:O30444 (EMBL%3B AF006000) hypothetical 26.3 KD protein (252 aa)%2C fasta scores opt: 742 z-score: 794.0 E(): 0 47.4%25 identity in 247 aa overlap. gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0441 SCO0442 SCO0442 SCF51A.20 SCF51A.20 462099 462857 + hypothetical protein SCF51A.20%2C unknown%2C len: 252 aa. Similar to a number of hypothetical proteins e.g. Escherichia coli SW:YBGJ_ECOLI (EMBL%3B AE000174) hypothetical 23.9 KD protein in phrB-nei intergenic region (218 aa)%2C fasta scores: opt: 477 z-score: 492.1 E(): 4.7e-20 43.5%25 identity in 214 aa overlap gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0442 SCO0443 SCO0443 SCF51A.21 SCF51A.21 462854 463711 + hypothetical protein SCF51A.21%2C unknown%2C len: 285 aa. Similar to a number of hypothetical proteins e.g. Mycobacterium tuberculosis TR:P95220 (EMBL%3B Z86089) hypothetical 32.2 KD protein (300 aa)%2C fasta scores opt: 714 z-score: 663.0 E(): 1.4e-29 45.3%25 identity in 289 aa overlap. Also similar in parts to Pseudomonas fluorescens TR:CAB48407 (EMBL%3B AJ243652) urea amidolyase homologue (1213 aa)%2C fasta scores opt: 423 z-score: 390.1 E(): 2.3e-14 37.7%25 identity in 289 aa overlap gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0443 SCO0444 SCO0444 SCF51A.22c SCF51A.22c 463698 464099 - hypothetical protein SCF51A.22c%2C possible integral membrane protein%2C len: 133 aa. Contains possible membrane spanning hydrophobic domains. gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0444 SCO0445 SCO0445 SCF51A.23c SCF51A.23c 464207 465502 - hypothetical protein SCF51A.23c%2C possible hypothetical protein%2C len: 405 aa. Contains a possible N-terminal signal sequence. gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0445 SCO0446 SCO0446 SCF51A.24c SCF51A.24c 465496 465861 - hypothetical protein SCF51A.24c%2C unknown%2C len: 121 aa%3B similar to C-terminal of SCF51A.23C TR:Q9RL41 (EMBL:AL121596) hypothetical protein from Streptomyces coelicolor (431 aa) fasta scores%3B opt: 408%2C Z-score: 470.3%2C E(): 1.4e-18%2C 70.115%25 identity (70.115%25 ungapped) in 87 aa overlap. gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0446 SCO0447 SCO0447 SCF51A.25 SCF51A.25 465990 466436 + MarR family regulatory protein SCF51A.25%2C possible MarR-family regulatory protein%2C len: 148 aa. Similar to many hypothetical proteins with similarity to the MarR family of transcriptional regulators e.g. Mycobacterium tuberculosis SW: YZ08_MYCTU (EMBL%3B Z73101) hypothetical 15.6 KD protein CY31.08 (143 aa)%2C fasta scores opt: 256 z-score: 328.8 E(): 5.9e-11 34.1%25 identity in 135 aa overlap. Contains a Pfam match to entry PF01047 MarR%2C MarR family gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0447 SCO0448 SCO0448 SCF51A.26 SCF51A.26 466504 467909 + gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0448 SCO0449 SCO0449 SCF51A.27 SCF51A.27 468153 469232 + solute-binding lipoprotein SCF51A.27%2C possible solute-binding lipoprotein %2C len: 359 aa. Weakly similar to many solute-binding proteins e.g. Streptomyces coelicolor TR:O69944 (EMBL%3B AL023862) solute binding protein SC3F9.04 (348 aa)%2C fasta scores opt: 231 z-score: 259.4 E(): 4.3e-07 23.2%25 identity in 366 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to%2C PS00013%2C a prokaryotic membrane lipoprotein lipid attachment site. gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0449 SCO0450 SCO0450 SCF51A.28c SCF51A.28c 469315 470304 - hypothetical protein SCF51A.28c%2C possible integral membrane protein%2C len: 326 aa. Weakly similar to a number of sensory transduction histidine kinases e.g. Synechocystis sp. (strain PCC 6803) TR:P72791 (EMBL%3B D90900) (834 aa)%2C fasta scores opt: 172 z-score: 187.7 E(): 0.0042 23.7%25 identity in 317 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0450 SCO0451 SCO0451 SCF51A.29c SCF51A.29c 470355 471209 - hypothetical protein SCF51A.29c%2C unknown%2C len: 284 aa. Similar to the C-terminus of many hypothetical proteins e.g. Mycobacterium tuberculosis SW:Y07S_MYCTU (EMBL%3B Z75555) hypothetical 69.5 KD protein CY02B10.28C (653 aa)%2C fasta scores opt: 390 z-score: 451.1 E(): 9.1e-18 33.5%25 identity in 263 aa overlap. In addition to Bacillus subtilis SW:RSBU_BACSU (EMBL%3B L35574) sigma factor SibG regulation protein RsbU (335 aa)%2C fasta scores opt: 206 z-score: 243.6 E(): 3.3e-06 24.3%25 identity in 185 aa overlap. gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0451 SCO0452 SCO0452 SCF51A.30 SCF51A.30 471415 472314 + SIR2-like regulatory protein SCF51A.30%2C possible SIR2-like regulatory protein%2C len: 299 aa. Similar to several Eukaryotic proteins e.g. Homo sapiens TR:AAD40852 (EMBL%3B AF083109) sirtuin type 4 (314 aa)%2C fasta scores opt: 736 z-score: 829.3 E(): 0 46.3%25 identity in 255 aa overlap. Also similar to several Prokaryotic proteins e.g. Archaeoglobus fulgidus TR:O30124 (EMBL%3B AE001098) transcriptional regulatory protein%2C SIR2 family (253 aa)%2C fasta scores opt: 319 z-score: 364.7 E(): 5.9e-13 31.9%25 identity in 257 aa overlap. gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0452 SCO0453 SCO0453 SCF51A.31 SCF51A.31 472458 473747 + solute-binding lipoprotein SCF51A.31%2C probable solute-binding lipoprotein%2C len: 429 aa. Weakly similar to many solute-binding proteins e.g. Bacillus subtilis SW:YURO_BACSU (EMBL%3B Z99120) hypothetical ABC transporter extracellular binding protein YurO (422 aa)%2C fasta scores opt: 235 z-score: 270.1 E(): 1.1e-07 19.9%25 identity in 422 aa overlap. Contains a Pfam match to entry PF01547 SBP_bacterial_1%2C an appropriately positioned Prosite hit to PS00013%2C a prokaryotic membrane lipoprotein lipid attachment site and also contains a possible N-terminal signal sequence. gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0453 SCO0454 SCO0454 SCF51A.32 SCF51A.32 473848 474789 + binding-protein dependent transport protein SCF51A.32%2C probable binding-protein dependent transport protein%2C len: 313 aa. Similar to many including: Streptomyces coelicolor TR:CAB41203 (EMBL%3B AL049661) protein SCE134.05C (327 aa)%2C fasta scores opt: 479 z-score: 546.7 E(): 4.3e-23 31.4%25 identity in 315 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and a Prosite hit to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains multiple possible membrane spanning hydrophobic domains. gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0454 SCO0455 SCO0455 SCF51A.33 SCF51A.33 474804 475631 + binding-protein dependent transport protein SCF51A.33%2C binding-protein dependent transport protein%2C len: 274 aa. Similar to many e.g. Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) TR:O30833 (EMBL%3B AF018073) sorbitol/mannitol transport inner membrane protein (276 aa)%2C fasta scores opt: 452 z-score: 556.9 E(): 1.2e-23 32.0%25 identity in 272 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains multiple possible membrane spanning hydrophobic domains. gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0455 SCO0456 SCO0456 SCF51A.34 SCF51A.34 475628 476671 + LacI family transcriptional regulator SCF51A.34%2C possible LacI family transcriptional regulator%2C len: 347 aa. Highly similar to several including: Escherichia coli SW:CYTR_ECOLI (EMBL%3B X03683) transcriptional repressor CytR (341 aa)%2C fasta scores opt: 504 z-score: 574.2 E(): 1.3e-24 31.6%25 identity in 339 aa overlap and Streptomyces coelicolor TR:O86598 (EMBL%3B AL031514) transcriptional regulator SC2H4.15 (342 aa)%2C fasta scores opt: 807 z-score: 915.3 E(): 0 44.4%25 identity in 333 aa overlap. Contains a Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C a Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and a possible helix-turn-helix motif between residues 13..34 (+5.95 SD). gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0456 SCO0457 SCO0457 SCF51A.35 SCF51A.35 476738 478672 + hypothetical protein SCF51A.35%2C unknown%2C len: 644 aa gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0457 SCO0458 SCO0458 SCF51A.36 SCF51A.36 478669 480957 + Beta-glucosidase SCF51A.36%2C probable Beta-glucosidase (EC 3.2.1.21)%2C len: 762 aa. Highly similar to many e.g. Escherichia coli SW:BGLX_ECOLI (EMBL%3B U15049) periplasmic Beta-glucosidase precursor (EC 3.2.1.21) (765 aa)%2C fasta scores opt: 851 z-score: 896.9 E(): 0 32.2%25 identity in 773 aa overlap. Contains 2x Pfam matches to entry PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3. gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0458 SCO0459 SCO0459 SCF51A.37 SCF51A.37 481012 481791 + hypothetical protein SCF51A.37%2C unknown%2C len: 259 aa. Similar to Mycobacterium tuberculosis SW:YX26_MYCTU (EMBL%3B Z74024) hypothetical 30.6 KD protein CY274.26C (283 aa)%2C fasta scores opt: 268 z-score: 318.2 E(): 2.3e-10 28.9%25 identity in 263 aa overlap. gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0459 SCO0460 SCO0460 SCF51A.38 SCF51A.38 481810 482319 - hypothetical protein SCF51A.38%2C unknown%2C len: 169 aa. gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0460 SCO0461 SCO0461 SCF51A.39 SCF51A.39 482456 483325 + hydrolase SCF76.01%2C possible hydrolase%2C partial CDS%2C len: >228 aa. Similar to several hypothetical proteins e.g. from Saccharomyces cerevisiae SW:YN93_YEAST (EMBLL:Z71679) (290 aa)%2C fasta scores opt: 609 z-score: 749.0 E():0 42.4%25 identity in 229 aa overlap. Also weakly similar to Xanthobacter autotrophicus SW:HALO_XANAU (EMBL:M26950) haloalkane dehalogenase (EC 3.8.1.5) (310 aa)%2C fasta scores opt: 151 z-score: 190.4 E():0.003 22.9%25 identity in 231 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold~SCF51A.39%2C possible hydrolase%2C partial CDS%2C len: >113 aa. Highly similar to Saccharomyces cerevisiae (Bakers yeast) SW:YN93_YEAST (EMBL%3B Z71679) hypothetical 32.8 KD protein in BIO3-HXT17 intergenic region. In addition to being similar to many dehalogenases e.g. Mycobacterium tuberculosis SW:YU14_MYCTU (EMBL%3B Z77163) haloalkane dehalogenase (EC 3.8.1.5) (300 aa)%2C fasta scores opt: 222 z-score: 292.5 E(): 6.2e-09 37.0%25 identity in 100 aa overlap gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0461 SCO0462 SCO0462 SCF76.02c SCF76.02c 483338 484267 - oxidoreductase SCF76.02c%2C possible oxidoreductase%2C len: 305 aa. Similar to many hypothetical proteins e.g. Pyrococcus horikoshii SW:APBA_PYRHO (EMBL%3B AP000006) probable 2-dehydropantoate 2-reductase (EC 1.1.1.169) (ketopantoate reductase) (KPA reductase) (301 aa)%2C fasta scores opt: 359 z-score: 419.9 E(): 4.9e-16 26.5%25 identity in 291 aa overlap and Streptomyces coelicolor TR:Q9ZBV6 (EMBL:AL034443) oxidoreductase SC4B5.12C (323 aa)%2C fasta scores opt: 233 z-score: 274.7 E(): 6.1e-08 32.0%25 identity in 322 aa overlap. gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0462 SCO0463 SCO0463 SCF76.03 SCF76.03 484318 484932 + hypothetical protein SCF76.03%2C unknown%2C len: 204 aa%3B similar to TR:Q9L1U0 (EMBL:AL138851) SCE59.14C hypothetical protein from Streptomyces coelicolor (196 aa) fasta scores%3B opt: 357%2C Z-score: 418.9%2C E(): 1.1e-15%2C 37.433%25 identity (40.230%25 ungapped) in 187 aa overlap. gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0463 SCO0464 SCO0464 SCF76.04c SCF76.04c 484973 486670 - hypothetical protein SCF76.04c%2C possible integral membrane protein%2C len: 565 aa. Similar in parts to many hypothetical proteins e.g. Streptomyces lividans TR:O86875 (EMBL%3B U22894) hypothetical 57.9 KD protein (547 aa)%2C fasta scores opt: 689 z-score: 806.6 E(): 0 41.7%25 identity in 439 aa overlap and Streptomyces coelicolor TR:O86807 (EMBL%3B AL031031) regulatory protein (916 aa)%2C fasta scores opt: 329 z-score: 381.2 E(): 7.1e-14 26.5%25 identity in 582 aa overlap. Contains a Pfam match to entry PF01590 GAF%2C GAF domain and possible membrane spanning hydrophobic domains. gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0464 SCO0465 SCO0465 SCF76.05c SCF76.05c 486684 487514 - non-heme chloroperoxidase SCF76.05c%2C non-heme chloroperoxidase (chloride peroxidase)%2C len: 276 aa. Identical to Streptomyces lividans SW:PRXC_STRLI (EMBL%3B U02635) non-heme chloroperoxidase (EC 1.11.1.10) (chloride peroxidase)(CPO-L) (chloroperoxidase L) (275 aa)%2C fasta scores opt: 1866 z-score: 2162.6 E():0 99.3%25 identity in 275 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0465 SCO0466 SCO0466 SCF76.06 SCF76.06 487618 488601 + AraC family transcription regulator SCF76.06%2C probable araC family transcriptional regulator%2C len: 327 aa. Highly similar to many including the Streptomyces coelicolor hypothetical regulators: TR:CAB40696 (EMBL%3B AL049587) SC5F2A.29 (325 aa)%2C fasta scores opt: 857 z-score: 962.2 E():0 45.8%25 identity in 323 aa overlap and TR:CAB46927 (EMBL%3B AL096822) SCGD3.05 (334 aa)%2C fasta scores opt: 617 z-score: 694.7 E(): 2.4e-31 38.6%25 identity in 332 aa overlap. In addition to Streptomyces lividans SW:YCP1_STRLI (EMBL%3B U02635) hypothetical protein in CPOL 5'region (ORF1) (fragment) (141 aa)%2C fasta scores opt: 908 z-score: 1024.0 E():0 99.3%25 identity in 141 aa overlap. Contains a Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. There are two possible helix-turn-helix motifs located between residues 237..258 (+3.99 SD) and 301..322 (+2.58 SD). Note that the translational start site may be 'M' residue 6. gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0466 SCO0467 SCO0467 SCF76.07 SCF76.07 488614 489357 + hypothetical protein SCF76.07%2C unknown%2C len: 247 aa%3B similar to TR:Q98LL0 (EMBL:AP002996) MLR0982 protein from Rhizobium loti (Mesorhizobium loti) (215 aa) fasta scores%3B opt: 410%2C Z-score: 484.9%2C E(): 2.2e-19%2C 33.178%25 identity (33.649%25 ungapped) in 214 aa overlap. gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0467 SCO0468 SCO0468 SCF76.08c SCF76.08c 489373 490350 - hypothetical protein SCF76.08c%2C unknown%2C len: 325 aa. The N-terminus is highly similar to several PIRIN proteins e.g. Alcaligenes eutrophus TR: AAD21775 (EMBL%3B J05278) PIRIN (187 aa)%2C fasta scores opt: 446 z-score: 495.3 E(): 3.1e-20 49.7%25 identity in 149 aa overlap. Also similar to several hypothetical proteins e.g. Mycobacterium tuberculosis TR:O07425 (EMBL%3B Z97050) hypothetical 26.3 KD protein (244 aa)%2C fasta scores opt: 269 z-score: 301.6 E(): 1.9e-09 32.7%25 identity in 217 aa overlap. gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0468 SCO0469 SCO0469 SCF76.09 SCF76.09 490451 490972 + hypothetical protein SCF76.09%2C unknown%2C len: 173 aa. Weakly similar in parts to Bacillus subtilis TR:P96684 (EMBL%3B AB001488) YDFG protein (147 aa)%2C fasta scores opt: 260 z-score: 329.6 E(): 5.3e-11 35.1%25 identity in 111 aa overlap. gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0469 SCO0470 SCO0470 SCF76.10 SCF76.10 490983 491891 + hydrolase SCF76.10%2C possible hydrolase%2C len: 302 aa. Weakly similar to hydrolases e.g. the N-terminal%2C domain of Streptomyces coelicolor TR:O86608 (EMBL:AL031155) 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (449 aa)%2C fasta scores opt: 387 z-score: 428.9 E(): 1.6e-16 33.7%25 identity in 258 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0470 SCO0471 SCO0471 SCF76.11 SCF76.11 491901 492881 + AraC family transcription regulator SCF76.11%2C possible araC family transcriptional regulator%2C len: 326 aa. Weakly similar to the DNA-binding domains of other transcriptional regulators e.g. Escherichia coli SW:ARAC_ECOLI (EMBL%3B V00256) arabinose operon regulatory protein (292 aa)%2C fasta scores opt: 130 z-score: 151.4 E(): 0.45 28.2%25 identity in 163 aa overlap. Contains a Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. The helix-turn-helix motif is located between residues 197..218 (+2.74 SD). Also contains a possible membrane spanning hydrophobic domain. gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0471 SCO0472 SCO0472 SCF76.12c SCF76.12c 493055 494263 - hypothetical protein SCF76.12c%2C possible hypothetical protein%2C len: 384 aa. Contains a possible N-terminal signal sequence. gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0472 SCO0473 SCO0473 SCF76.13c SCF76.13c 494260 495249 - solute-binding lipoprotein SCF76.13c%2C possible solute-binding lipoprotein%2C len: 329 aa. Similar to many e.g. Streptococcus parasanguis SW:ADHS_STRPA (EMBL%3B M26130) adhesin B precursor (saliva-binding protein) (309 aa)%2C fasta scores opt: 354 z-score: 399.1 E(): 7.2e-15 23.7%25 identity in 317 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C a Pfam match to entry PF01297 Lipoprotein_4%2C Adhesion lipoprotein and a possible N-terminal signal sequence. gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0473 SCO0474 SCO0474 SCF76.14c SCF76.14c 495246 496493 - lipoprotein SCF76.14c%2C possible lipoprotein%2C len: 415 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0474 SCO0475 SCO0475 SCF76.15c SCF76.15c 496508 497359 - ABC transporter SCF76.15c%2C probable ABC transporter%2C integral membrane subunit%2C len: 283 aa. Similar to many e.g. Escherichia coli SW:ZNUB_ECOLI (EMBL%3B AE000280) high-affinity zinc uptake system membrane protein ZnuB (261 aa)%2C fasta scores opt: 442 z-score: 483.2 E(): 1.5e-19 32.5%25 identity in 246 aa overlap. Contains a Pfam match to entry PF00950 ABC-3%2C ABC 3 transport family and multiple possible membrane spanning hydrophobic domains. gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0475 SCO0476 SCO0476 SCF76.16 SCF76.16 497375 498133 + ABC transporter ATP-binding protein SCF76.16%2C ABC transporter%2C ATP-binding subunit%2C len: 252 aa. Similar to many e.g. Haemophilus influenzae SW:FECE_HAEIN (EMBL%3B U32720) iron(III) dicitrate transport ATP-binding protein FecE homolog (306 aa)%2C fasta scores opt: 375 z-score: 413.4 E(): 1.2e-15 37.3%25 identity in 185 aa overlap. Contains a Prosite hit to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0476 SCO0477 SCO0477 SCF76.17 SCF76.17 498238 498630 + hypothetical protein SCF76.17%2C conserved hypothetical protein%2C len: 130 aa. Highly similar to several including: Bacillus subtilis TR:O32161 (EMBL%3B Z99120) YurT protein (127 aa)%2C fasta scores opt: 494 z-score: 605.8 E(): 2.2e-26 58.6%25 identity in 128 aa overlap%2C Streptomyces coelicolor TR:CAB42950 (EMBL%3B AL049863) hypothetical 14.4 KD protein SC5H1.25C (131 aa)%2C fasta scores opt: 221 z-score: 280.0 E(): 3.1e-08 37.2%25 identity in 129 aa overlap and also weakly similar to some lyases e.g. Salmonella typhimurium SW:LGUL_SALTY (EMBL%3B U57364) lactoylglutathione lyase (EC 4.4.1.5) (135 aa)%2C fasta scores opt: 101 z-score: 136.7 E(): 2.9 23.1%25 identity in 134 aa overlap gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0477 SCO0478 SCO0478 SCF76.18c SCF76.18c 498683 499807 - hypothetical protein SCF76.18c%2C possible membrane protein%2C len: 374 aa. Contains a possible membrane spanning hydrophobic domain. gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0478 SCO0479 SCO0479 SCF76.19c SCF76.19c 499952 500776 - phosphatase SCF76.19c%2C phosphatase%2C len: 274 aa. Almost identical to Streptomyces lividans TR:O70034 (EMBL%3B AJ223365) Sbl1 gene (274 aa)%2C fasta scores opt: 1764 z-score: 2005.4 E():0 97.1%25 identity in 274 aa overlap. Also weakly similar to many inositol monophosphatases e.g. Mycobacterium smegmatis TR:O51845 (EMBL%3B AF005905) inositol monophosphate phosphatase (276 aa)%2C fasta scores opt: 299 z-score: 346.7 E(): 6e-12 33.1%25 identity in 269 aa overlap and Escherichia coli SW: SUHB_ECOLI (EMBL%3B M34828) extragenic suppressor protein SuhB (267 aa)%2C fasta scores opt: 269 z-score: 313.0 E(): 4.6e-10 30.8%25 identity in 263 aa overlap. gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0479 SCO0480 SCO0480 SCF76.20 SCF76.20 500780 501412 + hypothetical protein SCF80.01%2C unknown%2C partial CDS%2C len: >193 aa. Similar in parts to Streptomyces coelicolor TR:CAB53333 (EMBL%3BAL109974) hypothetical 34.2 KD protein SCF34.22 (326 aa)%2C fasta scores opt:opt: 296 z-score: 300.2 E(): 2.4e-09 40.5%25 identity in 148 aa overlap.~SCF76.20%2C unknown%2C partial CDS%2C len: >49 aa. gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0480 SCO0481 SCO0481 SCF80.02 SCF80.02 501699 502217 + chitin binding protein SCF80.02%2C possible chitin binding protein%2C len: 172 aa. This CDS has been previously sequenced but was unclassified: Streptomyces coelicolor TR:Q9Z9M5 (EMBL%3B AB017013) gene for ChiG%2C partial CDS (fragment) (172 aa)%2C fasta scores opt: 1151 z-score: 1339.7 E():0 99.4%25 identity in 172 aa overlap. This CDS is similar to several e.g. Streptomyces reticuli TR:O87962 (EMBL%3B Y14315) chitin binding protein (Chb2) (201 aa)%2C fasta scores opt: 193 z-score: 234.7 E(): 1e-05 37.3%25 identity in 201 aa overlap. Contains a possible N-terminal signal sequence. gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0481 SCO0482 SCO0482 chiG chiG 502342 503076 + chitinase SCF80.03%2C chitinase%2C partial CDS%2C len:> 187 aa. Previously sequenced and characterised. Streptomyces coelicolor TR:Q9Z9M4 (EMBL%3B AB017013) chiG (fragment) (244 aa)%2C fasta scores opt: 1238 z-score: 1463.2 E():0 98.9%25 identity in 187 aa overlap. Contains a possible N-terminal signal sequence and a Pfam match to entry PF00182 Glyco_hydro_19%2C Chitinases class I.~SCF34.01%2C chiG%2C chitinase%2C partial CDS%2C len: >90 aa%3B identical to the C-terminus of TR:Q9Z9M4 (EMBL:AB017013)%2C chiG%2C Streptomyces coelicolor chitinase (fragment) (244 aa)%2C fasta scores%3B opt: 638 z-score: 812.8 E(): 0%2C 100.0%25 identity in 90 aa overlap. Highly similar to SC5H1.29c (EMBL:AL049863)%2C chiF%2C Streptomyces coelicolor chitinase (296 aa) (81.1%25 identity in 90 aa overlap). Contains Pfam match to entry PF00182 Glyco_hydro_19%2C Chitinases class I gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0482 SCO0483 SCO0483 SCF34.02c SCF34.02c 503073 503474 - hypothetical protein SCF34.02c%2C hypothetical protein%2C len: 133 aa%3B unknown function%2C possible CDS suggested by GC frameplot. Contains an Arg-rich region gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0483 SCO0484 SCO0484 SCF34.03c SCF34.03c 503539 504705 - monooxygenase SCF34.03c%2C possible monooxygenase%2C len: 388 aa%3B similar to SW:TETX_BACFR (EMBL:M37699)%2C TetX%2C Bacteroides fragilis tetracycline resistance protein from transposon Tn4351/Tn4400 (388 aa)%2C fasta scores%3B opt: 582 z-score: 637.6 E(): 3.7e-28%2C 33.9%25 identity in 351 aa overlap. Also similar to monooxygenases e.g. TR:P96555 (EMBL:AB000564) Sphingomonas sp. salicylate hydroxylase (395 aa) (27.2%25 identity in 360 aa overlap). Similar to others from S.coelicolor e.g. TR:Q9Z4Y6 (EMBL:AL035707) S.coelicolor possible salicylate hydroxylase (420 aa) (32.9%25 identity in 340 aa overlap). Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase gene gene470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0484 SCO0485 SCO0485 SCF34.04 SCF34.04 504854 505465 + TetR family transcriptional regulator SCF34.04%2C possible tetR-family transcriptional regulator%2C len: 203 aa%3B shows weak similarity to SW:TCMR_STRGA (EMBL:M80674)%2C TcmR%2C Streptomyces glaucescens tetracenomycin C transcriptional repressor (226 aa)%2C fasta scores%3B opt: 201 z-score: 254.2 E(): 8.4e-07%2C 32.2%25 identity in 152 aa overlap and to many transcriptional regulators. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Contains probable helix-turn-helix motif at aa 38-59 (Score 1212%2C +3.31 SD) gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0485 SCO0486 SCO0486 SCF34.05c SCF34.05c 505447 506670 - monooxygenase SCF34.05c%2C possible monooxygenase%2C len: 407 aa%3B similar to TR:Q9ZI64 (EMBL:AF039534)%2C NahW%2C Pseudomonas stutzeri salicylate hydroxylase (389 aa)%2C fasta scores%3B opt: 328 z-score: 383.8 E(): 5.1e-14%2C 27.0%25 identity in 403 aa overlap and to the N-terminal half of some epoxidases e.g. SW:ABA2_LYCES (EMBL:Z83835) Lycopersicon esculentum zeaxanthin epoxidase precursor (669 aa) (26.8%25 identity in 336 aa overlap). Also similar to many oxidoreductases e.g. TR:O54177 (EMBL:AL021411) Streptomyces coelicolor possible oxidoreductase (397 aa) (56.1%25 identity in 403 aa overlap). Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0486 SCO0487 SCO0487 SCF34.06 SCF34.06 506842 507348 + MarR family transcriptional regulator SCF34.06%2C possible MarR-family transcriptional regulator%2C len: 168 aa%3B shows weak similarity to TR:Q53002 (EMBL:U51475)%2C MucS%2C Rhizobium meliloti exopolysaccharide synthesis regulatory protein (190 aa)%2C fasta scores%3B opt: 126 z-score: 160.1 E(): 0.15%2C 24.8%25 identity in 145 aa overlap and to hypothetical transcriptional regulators. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0487 SCO0488 SCO0488 SCF34.07 SCF34.07 507394 510810 + hydrolase SCF34.07%2C hydrolase%2C len: 1138 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Similar to TR:Q9S3L0 (EMBL:AJ238748) alfa-L-ramnisidase from Clostridium stercorarium (874 aa) fasta scores%3B opt: 554%2C Z-score: 585.8%2C E(): 5.4e-25%2C 27.513%25 identity (30.672%25 ungapped) in 796 aa overlap. gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0488 SCO0489 SCO0489 SCF34.08c SCF34.08c 510823 511035 - hypothetical protein SCF34.08c%2C conserved hypothetical protein%2C len: 70 aa%3B unknown function%2C similar to hypothetical proteins from several bacteria e.g. SW:MBTH_MYCTU (EMBL:Z95208)%2C MbtH%2C Mycobacterium tuberculosis hypothetical protein (71 aa)%2C fasta scores%3B opt: 329 z-score: 486.3 E(): 9.9e-20%2C 70.3%25 identity in 64 aa overlap. Also similar to TR:Q9Z388 (EMBL:AL035654) Streptomyces coelicolor small conserved hypothetical protein (71 aa) (74.2%25 identity in 62 aa overlap) gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0489 SCO0490 SCO0490 SCF34.09 SCF34.09 511124 512215 + esterase SCF34.09%2C possible esterase%2C len: 363 aa%3B similar to enterochelin esterases e.g. SW:FES_ECOLI (EMBL:J04216)%2C Fes%2C Escherichia coli enterochelin esterase (374 aa)%2C fasta scores%3B opt: 422 z-score: 474.2 E(): 4.7e-19%2C 32.5%25 identity in 332 aa overlap gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0490 SCO0491 SCO0491 SCF34.10c SCF34.10c 512302 513924 - ABC transporter SCF34.10c%2C probable ABC-transporter transmembrane protein%2C len: 540 aa%3B similar to transporters e.g. SW:PRTD_ERWCH (EMBL:M60395)%2C PrtD%2C Erwinia chrysanthemi proteases secretion ATP-binding protein (575 aa)%2C fasta scores%3B opt: 433 z-score: 468.5 E(): 9.7e-19%2C 29.1%25 identity in 413 aa overlap. Similar to TR:O87312 (EMBL:AF027770)%2C FxtA%2C Mycobacterium smegmatis hypothetical protein at exochelin locus (574 aa) (39.7%25 identity in 524 aa overlap). Similar to others from S.coelicolor e.g. to the N-terminal half of TR:Q9ZBY5 (EMBL:AL034355)%2C CydCD%2C Streptomyces coelicolor probable ABC transporter (1172 aa) (29.6%25 identity in 550 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and PS00211 ABC transporters family signature gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0491 SCO0492 SCO0492 SCF34.11c SCF34.11c 513989 524920 - peptide synthetase SCF34.11c%2C probable peptide synthetase%2C len: 3643 aa%3B similar to parts of many antibiotic peptide synthetases e.g. the C-terminal half of TR:Q9Z4X6 (EMBL:AL035640) Streptomyces coelicolor CDA peptide synthetase I (7463 aa)%2C fasta scores%3B opt: 1948 z-score: 1929.3 E(): 0%2C 33.7%25 identity in 3723 aa overlap. Also similar to parts of peptide synthetases from the exochelin biosynthesis locus of Mycobacterium smegmatis TR:O87314 (EMBL:AF027770)%2C FxbC%2C peptide synthetase (4976 aa) (42.3%25 identity in 3756 aa overlap). Contains 3 Pfam matches to entry PF00550 pp-binding%2C Phosphopantetheine attachment site%2C 3 Pfam matches to entry PF00501 AMP-binding%2C AMP-binding enzyme%2C 4 Pfam matches to entry PF00668 DUF4%2C Domain of unknown function%2C 2 PS00455 AMP-binding domain signatures%2C 2 PS00012 Phosphopantetheine attachment sites and 1 PS00017 ATP/GTP-binding site motif A (P-loop) gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0492 SCO0493 SCO0493 SCF34.12c SCF34.12c 524978 526783 - ABC-transporter transmembrane protein SCF34.12c%2C probable ABC-transporter transmembrane protein%2C len: 601 aa%3B similar to the C-terminal half of TR:O85018 (EMBL:AF034152)%2C ExiT%2C Mycobacterium smegmatis ABC-transporter associated with ferric exochelin biosynthetic and uptake (possibly involved in exochelin secretion) (1122 aa)%2C fasta scores%3B opt: 1778 z-score: 1789.6 E(): 0%2C 50.4%25 identity in 585 aa overlap%2C to TR:Q54204 (EMBL:X89010)%2C StrW%2C Streptomyces glaucescens ABC-transporter from the hydroxystreptomycin production locus (591 aa) (33.1%25 identity in 577 aa overlap) and to many other ABC-transporters. Similar to many others from S.coelicolor e.g. to the C-terminal half of TR:Q9ZBY5 (EMBL:AL034355) CydCD%2C S.coelicolor probable ABC transporter (1172 aa) (30.3%25 identity in 574 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0493 SCO0494 SCO0494 SCF34.13c SCF34.13c 526786 527838 - iron-siderophore binding lipoprotein SCF34.13c%2C probable iron-siderophore binding lipoprotein%2C len: 350 aa%3B similar to TR:Q46023 (EMBL:U02617) Corynebacterium diphtheriae DtxR/iron-regulated lipoprotein precursor (355 aa)%2C fasta scores%3B opt: 479 z-score: 518.8 E(): 1.5e-21%2C 34.4%25 identity in 358 aa overlap and SW:FATB_VIBAN (EMBL:J03529)%2C FatB%2C Vibrio anguillarum plasmid pJM1 ferric anguibactin-binding protein precursor (322 aa) (26.2%25 identity in 305 aa overlap). Also similar to other iron-siderophore binding proteins. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. Contains Pfam match to entry PF01497 Peripla_BP_2. Contains a probable coiled-coil from 189 to 219 (31 residues) (Max score: 1.558%2C probability 0.98) gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0494 SCO0495 SCO0495 SCF34.14c SCF34.14c 527889 528752 - iron-siderophore ABC-transporter ATP-binding protein SCF34.14c%2C probable iron-siderophore ABC-transporter ATP-binding protein%2C len: 287 aa%3B similar to SW:FEPC_ECOLI (EMBL:X57471)%2C FepC%2C Escherichia coli ferric enterobactin transport ATP-binding protein (271 aa)%2C fasta scores%3B opt: 946 z-score: 1003.1 E(): 0%2C 52.3%25 identity in 262 aa overlap and to many other iron-siderophore ATP-binding proteins. Similar to many others from S. coelicolor e.g. SCI51.25c (EMBL:AL109848) S.coelicolor probable iron-siderophore uptake system ATP-binding component (301 aa) (58.9%25 identity in 258 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0495 SCO0496 SCO0496 SCF34.15c SCF34.15c 528791 529897 - iron-siderophore permease transmembrane protein SCF34.15c%2C probable iron-siderophore permease transmembrane protein%2C len: 368 aa%3B similar to SW:FEPG_ECOLI (EMBL:X57471)%2C FepG%2C Escherichia coli ferric enterobactin transport protein (330 aa)%2C fasta scores%3B opt: 741 z-score: 794.3 E(): 0%2C 38.7%25 identity in 326 aa overlap and to many other iron-siderophore permeases. Similar to others from S. coelicolor e.g. SCI51.26c (EMBL:AL109848) S. coelicolor probable iron-siderophore uptake system transmembrane component (375 aa) (45.9%25 identity in 333 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF01032 FecCD_family%2C FecCD transport family gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0496 SCO0497 SCO0497 SCF34.16c SCF34.16c 529894 530970 - iron-siderophore permease transmembrane protein SCF34.16c%2C probable iron-siderophore permease transmembrane protein%2C len: 358 aa%3B similar to SW:FEPD_ECOLI (EMBL:X57471)%2C FepD%2C Escherichia coli ferric enterobactin transport protein (334 aa)%2C fasta scores%3B opt: 796 z-score: 833.5 E(): 0%2C 43.9%25 identity in 330 aa overlap and to many other iron-siderophore permeases. Similar to others from S.coelicolor e.g. SCI51.27c (EMBL:AL109848) S.coelicolor probable iron-siderophore uptake system transmembrane component (348 aa) (46.8%25 identity in 344 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF01032 FecCD_family%2C FecCD transport family gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0497 SCO0498 SCO0498 SCF34.17c SCF34.17c 530970 532325 - peptide monooxygenase SCF34.17c%2C probable peptide monooxygenase%2C len: 451 aa%3B similar to monooxygenases/hydroxylases associated with peptide siderophore biosynthesis e.g. SW:PVDA_BURCE (EMBL:AF013993)%2C PvdA%2C Burkholderia cepacia L-ornithine 5-monooxygenase (444 aa)%2C fasta scores%3B opt: 982 z-score: 1149.4 E(): 0%2C 43.5%25 identity in 405 aa overlap and SW:IUCD_ECOLI (EMBL:M18968)%2C IucD%2C Escherichia coli L-lysine 6-monooxygenase (425 aa) (31.3%25 identity in 425 aa overlap). Also similar to others from S.coelicolor e.g. TR:Q9ZBH9 (EMBL:AL035206) S.coelicolor probable oxidoreductase%2C partial CDS (353 aa) (38.1%25 identity in 349 aa overlap) gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0498 SCO0499 SCO0499 SCF34.18 SCF34.18 532501 533448 + formyltransferase SCF34.18%2C possible formyltransferase%2C len: 315 aa%3B similar to TR:Q50378 (EMBL:U10425)%2C FxbA%2C Mycobacterium smegmatis formyltransferase required for exochelin biosynthesis (360 aa)%2C fasta scores%3B opt: 942 z-score: 1102.4 E(): 0%2C 49.5%25 identity in 309 aa overlap. Also similar to many methionyl-tRNA formyltransferases e.g. SW:FMT_PSEAE (EMBL:AF073952)%2C Fmt%2C Pseudomonas aeruginosa methionyl-tRNA formyltransferase (314 aa) (30.3%25 identity in 307 aa overlap). Contains Pfam match to entry PF00551 formyl_transf%2C Formyl transferase gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0499 SCO0500 SCO0500 SCF34.19c SCF34.19c 533534 533773 - hypothetical protein SCF34.19c%2C unknown%2C len: 79 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference%2C amino acid composition and the presence of a potential RBS gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0500 SCO0501 SCO0501 SCF34.20c SCF34.20c 533812 535764 - hypothetical protein SCF34.20c%2C hypothetical protein%2C len: 650 aa%3B unknown function%2C shows very weak similarity to SW:Y0D8_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical protein (628 aa)%2C fasta scores%3B opt: 233 z-score: 232.7 E(): 1.3e-05%2C 23.6%25 identity in 512 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0501 SCO0502 SCO0502 SCF34.21 SCF34.21 535974 536408 + hypothetical protein SCF34.21%2C possible membrane protein%2C len: 144 aa%3B unknown function%2C probable CDS suggested by GC frameplot and positional base preference. Contains hydrophobic%2C possible membrane-spanning regions gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0502 SCO0503 SCO0503 SCF34.22 SCF34.22 536532 537512 + hypothetical protein SCF34.22%2C hypothetical protein%2C len: 326 aa%3B unknown function%2C shows weak similarity to the N-terminal half of SCH10.22C (EMBL:AL049754) Streptomyces coelicolor lipase/esterase (301 aa)%2C fasta scores%3B opt: 178 z-score: 202.4 E(): 0.00065%2C 30.1%25 identity in 163 aa overlap gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0503 SCO0504 SCO0504 SCF34.23 SCF34.23 537623 538942 + DEAD/DEAH box helicase SCF34.23%2C probable DEAD-box RNA-helicase%2C len: 439 aa%3B similar to many e.g. to TR:O64430 (EMBL:AB010259)%2C Drh1%2C Arabidopsis thaliana DEAD box ATPase/RNA helicase (619 aa)%2C except where the A.thaliana protein is longer at the N-terminus%2C fasta scores%3B opt: 806 z-score: 892.9 E(): 0%2C 35.3%25 identity in 447 aa overlap. Also similar to many RNA-helicases e.g. SW:RHLE_ECOLI (EMBL:L02123)%2C RhlE%2C Escherichia coli ATP-dependent RNA helicase (454 aa) (36.4%25 identity in 451 aa overlap) and to TR:O54116 (EMBL:AL021529) Streptomyces coelicolor probable DEAD-box RNA-helicase (498 aa) (67.7%25 identity in 424 aa overlap). Contains Pfam matches to entry PF00270 DEAD%2C DEAD/DEAH box helicase and to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain. Contains 2 PS00017 ATP/GTP-binding site motif A (P-loop) gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0504 SCO0505 SCO0505 SCF34.24 SCF34.24 539123 542131 + large%2C multifunctional hypothetical protein SCF6.01%2C possible multi-domain protein%2C (fragment)%2C len: >152 aa. Highly similar to Amycolatopsis orientalis TR:CAB45032 (EMBL%3B AL078635) large multi-functional protein (987 aa)%2C fasta scores opt: 595 z-score: 714.7 E(): 1.9e-32 58.6%25 identity in 152 aa overlap.~SCF34.24%2C possible large%2C multifunctional hypothetical protein%2C partial CDS%2C len: >891 aa%3B contains a region of weak similarity to members of the glycosyl hydrolase family at approx. aa 700-890 e.g. to part of SW:CTA2_BACCI (EMBL:D88360)%2C Cit%2C Bacillus circulans cycloisomaltooligosaccharide glucanotransferase precursor (964 aa)%2C fasta scores%3B opt: 279 z-score: 292.6 E(): 6.1e-09%2C 33.3%25 identity in 213 aa overlap and region of very weak similarity at approx. aa 200-400 to part of a dehydrogenase SW:SNDH_ACELI (EMBL:D28511) Acetobacter liquefaciens L-sorbosone dehydrogenase (449 aa) (26.2%25 identity in 279 aa overlap). Similar to CZA382.11 (EMBL:AL078635) Amycolatopsis orientalis possible large%2C multifunctional protein (987 aa) (63.2%25 identity in 880 aa overlap). Contains a probable N-terminal signal sequence gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0505 SCO0506 SCO0506 nadE nadE 542269 543099 + NAD synthetase catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP%3B ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one%3B forms homodimers gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0506 SCO0507 SCO0507 SCF6.03c SCF6.03c 543119 543535 - hypothetical protein SCF6.03c%2C unknown%2C len: 138 aa. Similar to the C-terminus of many hypothetical oxidoreductases e.g. Streptomyces coelicolor TR: CAB53280 (EMBL%3B AL109972) oxidoreductase SCJ9A.19C (311 aa)%2C fasta scores opt: 307 z-score: 331.8 E(): 4.1e-11 44.4%25 identity in 126 aa overlap. gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0507 SCO0508 SCO0508 SCF6.04 SCF6.04 543545 544087 + tetR family transcriptional regulator SCF6.04%2C possible tetR family transcriptional regulator%2C len: 180 aa. Similar to many e.g. Streptomyces glaucescens SW:TCMR_STRGA (EMBL:M80674) tetracenomycin C transcriptional repressor (226 aa)%2C fasta scores opt: 225 z-score: 288.9 E(): 1e-08 34.5%25 identity in 174 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the possible helix-turn-helix motif between residues 13..34 (+3.92 SD). gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0508 SCO0509 SCO0509 glpK glpK 544194 545717 + glycerol kinase Converts glycerol and ADP to glycerol-3-phosphate and ADP gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0509 SCO0510 SCO0510 SCF6.06c SCF6.06c 545740 546147 - gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0510 SCO0511 SCO0511 SCF6.07 SCF6.07 546358 547116 + dehydrogenase SCF6.07%2C possible dehydrogenase (hypothetical protein)%2C len: 252 aa. Highly similar to many e.g. Pseudomonas paucimobilis SW:LINX_PSEPA (EMBL%3B D23722) 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-diol dehydrogenase (EC 1.1.-.-) (2%2C5-ddol dehydrogenase) LinX (250 aa)%2C fasta scores opt: 532 z-score: 558.4 E(): 9.7e-24 40.0%25 identity in 245 aa overlap. Also similar to many Streptomyces coelicolor oxidoreductases e.g. TR:O88068 (EMBL%3B AL031541) dehydrogenase SCI35.33C (260 aa)%2C fasta scores opt: 488 z-score: 438.3 E(): 4.1e-19 38.7%25 identity in 256 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and Pfam hits to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0511 SCO0512 SCO0512 SCF6.08c SCF6.08c 547135 547743 - regulatory protein SCF6.08c%2C possible regulatory protein%2C len: 202 aa. Similar to many other regulatory proteins e.g. Streptomyces coelicolor TR:CAB53122 (EMBL%3B AL109962) transcriptional regulatory protein SCJ1.04 (207 aa)%2C fasta scores opt: 436 z-score: 515.3 E(): 2.5e-21 44.4%25 identity in 196 aa overlap. gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0512 SCO0513 SCO0513 SCF6.09 SCF6.09 547809 548900 + hypothetical protein SCF6.09%2C integral membrane protein%2C len: 363 aa. Similar to a number of hypothetical integral membrane proteins e.g. Escherichia coli SW:PERM_ECOLI (EMBL%3B AE000335) permease PerM (353 aa)%2C fasta scores opt: 383 z-score: 425.2 E(): 2.6e-16 27.5%25 identity in 346 aa overlap and Mycobacterium tuberculosis TR:O53656 (EMBL%3B AL021928) hypothetical 38.0 KD protein (367 aa)%2C fasta scores opt: 687 z-score: 755.9 E():0 33.5%25 identity in 340 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Pfam match to entry PF01594 DUF20%2C permease. gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0513 SCO0514 SCO0514 SCF6.10 SCF6.10 548968 549621 + hypothetical protein SCF6.10%2C unknown%2C len: 217 aa. gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0514 SCO0515 SCO0515 SCF6.11 SCF6.11 549850 550458 + gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0515 SCO0516 SCO0516 SCF6.12 SCF6.12 550455 551633 + lipoprotein SCF6.12%2C possible lipoprotein%2C len:392 aa. Weakly similar to Methylobacterium extorquens TR:O30796 (EMBL%3B AF017434) hypothetical protein MxaE (281 aa)%2C fasta scores opt: 205 z-score: 214.7 E(): 0.00014 32.5%25 identity in 295 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0516 SCO0517 SCO0517 SCF6.13 SCF6.13 551918 552115 + hypothetical protein SCF6.13%2C hypothetical protein%2C len: 66 aa. Gene fragment shares a high level of similarity with Streptomyces coelicolor TR:CAB53135 (EMBL%3B AL109962) possible regulator protein SCJ1.17 (190 aa)%3B fasta scores: opt: 275 z-score: 356.5 E(): 1.7e-12%3B 62.1%25 identity in 66 aa overlap gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0517 SCO0518 SCO0518 SCF6.14 SCF6.14 552094 552351 + hypothetical protein SCF6.14%2C hypothetical protein%2C len: 86 aa. Gene fragment that is highly similar to Streptomyces coelicolor TR:Q9RI29 (EMBL:AL109989) nitrate reductase delta chain NarI2 (256 aa)%3B fasta scores: opt: 409 Z-score: 526.8 bits: 103.5 E(): 9.3e-22%3B 74.390%25 identity in 82 aa overlap gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0518 SCO0519 SCO0519 SCF6.15c SCF6.15c 552403 553140 - oxidoreductase SCF6.15c%2C possible oxidoreductase%2C len: 245 aa. Similar to many e.g. Bacillus megaterium SW:DHG2_BACME (EMBL%3B D90044) glucose 1-dehydrogenase II (EC 1.1.1.47) (GLCDH-II) (261 aa)%2C fasta scores opt: 402 z-score: 449.5 E(): 1.1e-17 35.1%25 identity in 228 aa overlap. Also similar to many other Streptomyces coelicolor oxidoreductases e.g. TR:CAB41284 (EMBL%3B AL049707) (260 aa)%2C fasta scores opt: 395 z-score: 365.3 E(): 4.8e-15 37.2%25 identity in 242 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0519 SCO0520 SCO0520 SCF6.16 SCF6.16 553277 553861 + tetR family transcriptional regulator SCF6.16%2C tetR family transcriptional regulator%2C len: 194 aa. Weakly similar to many other tetR family regulators e.g. Streptomyces sp. TR:O24741 (EMBL:AB001683) FarA (221 aa)%2C fasta scores opt: 161 z-score: 205.5 E(): 0.00044 28.4%25 identity in 190 aa overlap and Streptomyces coelicolor TR:O86852 (EMBL:AJ007731) gamma-butyrolactone binding protein (215 aa)%2C fasta scores opt: 149 z-score: 191.2 E(): 0.0028 26.6%25 identity in 188 aa overlap. Also highly similar to Streptomyces coelicolor SCF51A.08 (EMBL%3B AL121596) tetR family transcriptional regulator (227 aa)%2C fasta scores opt: 479 z-score: 463.7 E(): 1.5e-20 43.7%25 identity in 183 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. The possible helix-turn-helix motif lies between residues 36..57 (+4.21 SD). gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0520 SCO0521 SCO0521 SCF11.01 SCF11.01 553892 554473 + TetR family transcriptional regulator SCF11.01%2C possible tetR family transcriptional regulator%2C partial CDS%2C len: >32 aa. Previously annotated as Streptomyces coelicolor SCF6.17%2C possible tetR family trasncriptional regulator%2C len: >193 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB56142 (EMBL%3B AL117669) transcriptional regulator SCF12.15 (188 aa)%2C fasta scores opt:446 z-score: 521.2 E(): 1.2e-21 43.5%25 identity in 184 aa overlap and Streptomyces glaucescens SW:TCMR_STRGA (EMBL%3B M80674) tetracenomycin C transcriptional repressor (226 aa)%2C fasta scores opt: 202 z-score: 242.5 E(): 3.8e-06 29.3%25 identity in 164 aa overlap.~SCF6.17%2C possible tetR family transcriptional regulator%2C len: 193 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB56142 (EMBL%3B AL117669) transcriptional regulator SCF12.15 (188 aa)%2C fasta scores opt:446 z-score: 521.2 E(): 1.2e-21 43.5%25 identity in 184 aa overlap and Streptomyces glaucescens SW:TCMR_STRGA (EMBL%3B M80674) tetracenomycin C transcriptional repressor (226 aa)%2C fasta scores opt: 202 z-score: 242.5 E(): 3.8e-06 29.3%25 identity in 164 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. The possible helix-turn-helix motif lies between residues 29..50 (+2.70 SD). gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0521 SCO0522 SCO0522 SCF11.02 SCF11.02 554649 555440 + oxidoreductase SCF11.02%2C probable oxidoreductase%2C len: 262 aa%3B similar to TR:O54197 (EMBL:AJ000671) Streptomyces clavuligerus clavulanate-9-aldehyde reductase%2C 247 aa%3B fasta scores: opt: 501 z-score: 567.7 E(): 3e-24%3B 39.1%25 identity in 238 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and prosite match to entry PS00061 Short-chain dehydrogenases/reductases family signature. also similar to Streptomyces coelicolor SCF6.15c%2C 245 aa%3B fasta scores: opt: 818 z-score: 805.2 E():0%3B 56.5%25 identity in 237 aa overlap gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0522 SCO0523 SCO0523 SCF11.03c SCF11.03c 555468 555905 - transcriptional regulator SCF11.03c%2C probable transcriptional regulator%2C len: 145 aa%3B similar to SW:ASNC_ECOLI (EMBL:AE000451) Escherichia coli%2C regulatory protein AsnC%2C 152 aa%3B fasta scores: opt: 222 z-score: 287.1 E(): 1.3e-08%3B 26.9%25 identity in 145 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0523 SCO0524 SCO0524 SCF11.04 SCF11.04 555990 556898 + gluconolactonase SCF11.04%2C possible gluconolactonase%2C len: 302 aa%3B similar to SW:GNL_ZYMMO (EMBL:X67189) Zymomonas mobilis gluconolactonase precursor (EC 3.1.1.17) D-glucono-delta-lactone lactonohydrolase%3B fasta scores: opt: 326 z-score: 392.6 E(): 1.7e-14%3B 28.7%25 identity in 258 aa overlap gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0524 SCO0525 SCO0525 SCF11.05 SCF11.05 557029 557844 + hypothetical protein SCF11.05%2C hypothetical protein%2C len: 271 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB45341 (EMBL:AL079345) Streptomyces coelicolor SCE68.05C hypothetical 33.1 KD protein%2C 300 aa%3B fasta scores: opt: 808 z-score: 960.4 E(): 0%3B 53.2%25 identity in 250 aa overlap gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0525 SCO0526 SCO0526 SCF11.06 SCF11.06 557882 558715 + oxidoreductase SCF11.06%2C possible oxidoreductase%2C len: 277 aa%3B similar to TR:O53622 (EMBL:AL021428) Mycobacterium tuberculosis oxidoreductase MTV030.21c%2C 276 aa%3B fasta scores: opt: 276 z-score: 329.4 E(): 5.6e-11%3B 24.7%25 identity in 267 aa overlap and to SW:PRXC_PSEFL (EMBL:AF031153) Pseudomonas fluorescens non-heme chloroperodixase (EC 1.11.1.10) (chloride peroxidase) (CPO-F) (chloropeorixidase F) Cpo or CpoF%3B fasta scores: opt: 233 z-score: 279.3 E():3.5e-08%3B 26.1%25 identity in 283 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0526 SCO0527 SCO0527 SCF11.07c SCF11.07c 558812 559015 - cold shock protein SCF11.07c%2C scoF%2C cold shock protein%2C len: 67 aa. Identical to SW:CSPF_STRCO (EMBL:X92686) Streptomyces coelicolor cold shock protein ScoF and similar to SW:CSP7_STRCL (EMBL:X68245) Streptomyces clavuligerus cold shock-like protein 7.0%2C 66 aa%3B fasta scores: opt: 362 z-score: 493.9 E(): 3.8e-20%3B 74.6%25 identity in 67 aa overlap and to Streptomyces coelicolor SC10A5.26c%2C 67 aa%3B fasta scores: opt: 383 z-score: 518.2 E(): 1.5e-23%3B 82.1%25 identity in 67 aa overlap. Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain and Prosite match to entry PS00352 'Cold-shock' DNA-binding domain signature gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0527 SCO0528 SCO0528 SCF11.08 SCF11.08 559346 560098 + lipoprotein SCF11.08%2C possible lipoprotein%2C len: 261 aa%3B similar to various hypothetical proteins%2C e.g. TR:O07236 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 22.5 KD protein%2C 218 aa%3B fasta scores: opt: 157 z-score: 172.7 E(): 0.03%3B 25.3%25 identity in 194 aa overlap. Contains a Prosite match correctly situated to entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains probable N-terminal signal sequence gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0528 SCO0529 SCO0529 SCF11.09c SCF11.09c 560127 561545 - oxidoreductase SCF11.09c%2C probable oxidoreductase (hypothetical protein)%2C len: 508 aa%3B similar to TR:P75002 (EMBL:Z80356) Zymomonas mobilis glucose-fructose oxidoreductase precursor%2C 433 aa%3B fasta scores: opt: 270 z-score: 301.6 E(): 2e-09%3B 28.8%25 identity in 219 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C oxidoreductase family. Contains possible n-terminal region signal sequence peptide gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0529 SCO0530 SCO0530 SCF11.10c SCF11.10c 561731 562576 - transcriptional regulator SCF11.10c%2C possible transcriptional regulator%2C len: 281 aa%3B similar to SW:FARR_ECOLI (EMBL:X15790) Escherichia coli fatty acyl responsive regulator (P30 protein)%2C 240 aa%3B fasta scores: opt: 286 z-score: 325.5 E(): 9.2e-11%3B 27.7%25 identity in 224 aa overlap. Contains Pfam match to entry PF00392 gntR%2C bacterial regulatory proteins%2C gntR family and Prosite match to entry PS00043 bacterial regulatory proteins%2C gntR family signature. Contains a possible helix-turn-helix motif between residues 36..57%2C score 1211 (+3.31 SD) gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0530 SCO0531 SCO0531 SCF11.11 SCF11.11 562803 564071 + sugar transporter sugar binding protein SCF11.11%2C probable sugar transporter sugar binding protein%2C len: 422 aa%3B similar to TR:P72397 (EMBL:Y07706) Streptomyces coelicolor MalE%2C maltose-binding protein%2C 423 aa%3B fasta scores: opt: 367 z-score: 390.0 E(): 2.4e-14%3B 27.2%25 identity in 419 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C bacterial extracellular solute-binding protein and a prosite match correctly situated to entry PS00013 prokaryotic membrane lipoprotein lipid attachment site. Contains probable N-terminal signal sequence gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0531 SCO0532 SCO0532 SCF11.12 SCF11.12 564141 565049 + sugar transporter membrane protein SCF11.12%2C probable sugar transporter membrane protein%2C len: 302 aa%3B similar to TR:CAB55533 (EMBL:Y07706) Streptomyces coelicolor inner membrane protein MalF%2C 300 aa%3B fasta scores: opt: 493 z-score: 600.8 E(): 4.3e-26%3B 32.6%25 identity in 291 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C binding-protein-dependent transport systems inner membrane component and a prosite match to entry PS00402 binding-protein-dependent transport systems inner membrane component signature gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0532 SCO0533 SCO0533 SCF11.13 SCF11.13 565046 565903 + sugar transporter membrane protein SCF11.13%2C possible sugar transporter membrane protein%2C len: 285 aa%3B similar to TR:CAB46387 (EMBL:AL096743) Streptomyces coelicolor integral membrane transport protein MalG%2C 296 aa%3B fasta scores: opt: 538 z-score: 675.0 E(): 3.2e-30%3B 33.7%25 identity in 279 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C binding-protein-dependent transport systems inner membrane component and prosite match to entry PS00402 binding-protein-dependent transport systems inner membrane component signature gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0533 SCO0534 SCO0534 SCF11.14 SCF11.14 566007 567626 + beta-hexosaminidase SCF11.14%2C possible beta-hexosaminidase (hypothetical protein)%2C len: 539 aa%3B similar to TR:Q9ZH39 (EMBL:AF072374) Pseudoalteromonas sp. S9 beta-N-acetylglucosaminidase%2C 783 aa%3B fasta scores: opt: 1097 z-score: 1169.9 E(): 0%3B 36.6%25 identity in 527 aa overlap and SW:HEX1_VIBFU (EMBL:U41417) Vibrio furnissii beta-hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (beta-N-acetylhexosaminidase) ExoI: fasta scores: opt: 783 z-score: 836.7 E(): 0%3B 34.1%25 identity in 478 aa overlap. Contains Pfam match to entry PF00728 glyco_hydro_20%2C glycosyl hydrolase family 20 gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0534 SCO0535 SCO0535 SCF11.15 SCF11.15 567623 569044 + hydrolase SCF11.15%2C possible hydrolase (hypothetical protein)%2C len: 473 aa%3B similar to TR:AAD30364 (EMBL:AF078737) Caldicellulosiruptor sp. Tok7B.1 xylanase/endoglucanase%2C CelB%2C 1426 aa%3B fasta scores: opt: 484 z-score: 506.2 E(): 7.9e-21%3B 33.0%25 identity in 327 aa overlap. Contains a Pfam match to entry PF00942 CBD_3%2C cellulose binding domain. Contains possible n-terminal region signal sequence peptide gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0535 SCO0536 SCO0536 SCF11.16c SCF11.16c 569061 569282 - hypothetical protein SCF11.16c%2C unknown%2C len: 73 aa gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0536 SCO0537 SCO0537 SCF11.17 SCF11.17 569655 570482 + hypothetical protein SCF11.17%2C hypothetical hypothetical protein%2C len: 275 aa%3B highly similar to TR:P95755 (EMBL:D89734) Streptomyces griseus hypothetical protein adjacent to SgaA%2C 258 aa%3B fasta scores: opt: 858 z-score: 936.4 E(): 0%3B 54.9%25 identity in 264 aa overlap and to TR:CAB51262 (EMBL:AL096872) Streptomyces coelicolor endo alpha-1%2C4 polygalactosaminidase SC5F7.23c%2C 282 aa%3B fasta scores: opt: 303 z-score: 336.5 E(): 2.3e-11%3B 33.6%25 identity in 223 aa overlap. Contains probable N-terminal signal sequence gene gene523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0537 SCO0538 SCO0538 SCF11.18 SCF11.18 570520 571848 + sugar transporter sugar binding lipoprotein SCF11.18%2C probable sugar transporter sugar binding lipoprotein%2C len: 449 aa%3B similar to TR:AAD35680 (EMBL:AE001734) Thermotoga maritima sugar ABC transporter periplasmic sugar-binding protein TM0595%2C 419 aa%3B fasta scores: opt: 333 z-score: 361.2 E(): 9.5e-13%3B 24.1%25 identity in 406 aa overlap. Contains a Pfam match to entry PF01547 SBP_bacterial_1%2C bacterial extracellular solute-binding protein and probable N-terminal signal sequence gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0538 SCO0539 SCO0539 SCF11.19 SCF11.19 571863 572813 + sugar transporter membrane protein SCF11.19%2C probable sugar transporter membrane protein%2C len: 316 aa%3B similar to TR:CAB52981 (EMBL:AL109950) Streptomyces coelicolor integral membrane permease%2C 319 aa%3B fasta scores: opt: 606 z-score: 689.2 E(): 5.1e-31%3B 34.9%25 identity in 312 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C binding-protein-dependent transport systems inner membrane component and a prosite match to entry PS00402 binding-protein-dependent transport systems inner membrane component signature. Contains probable N-terminal signal sequence gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0539 SCO0540 SCO0540 SCF11.20 SCF11.20 572810 573709 + sugar transport membrane protein SCF11.20%2C probable sugar transport membrane protein%2C len: 299 aa%3B similar to TR:Q06111 (EMBL:X66092) Clostridium perfringens transport system permease%2C 275 aa%3B fasta scores: opt: 704 z-score: 838.6 E(): 0%3B 38.4%25 identity in 255 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C binding-protein-dependent transport systems inner membrane component and a prosite match to entry PS00402 binding-protein-dependent transport systems inner membrane component signature. Contains porbable N-terminal signal sequence gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0540 SCO0541 SCO0541 SCF11.21 SCF11.21 573756 575081 + alpha-galactosidase SCF11.21%2C probable alpha-galactosidase%2C len: 441 aa%3B similar to SW:AGAL_BACSU (EMBL:AF008220) Bacillus subtilis alpha-galactosidase (EC 3.2.1.22) (Melibiase) MelA%2C 432 aa%3B fasta scores: opt: 1068 z-score: 1240.5 E(): 0%3B 39.3%25 identity in 427 aa overlap gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0541 SCO0542 SCO0542 SCF11.22 SCF11.22 575351 577984 + regulatory protein SCF11.22%2C hypothetical regulatory protein%2C len: 877 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB44382 (EMBL:AL078610) Streptomyces coelicolor hypothetical 66.2 KD protein%2C 634 aa%3B fasta scores: opt: 1072 z-score: 1125.7 E(): 0%3B 38.2%25 identity in 678 aa overlap and to SW:RSBU_BACSU (EMBL:L35574) Bacillus subtilis sigma factor sibG regulation protein RsbU%2C 335 aa%3B fasta scores: opt: 211 z-score: 225.9 E(): 3.2e-05%3B 25.6%25 identity in 250 aa overlap. Contains Pfam matches to entries PF00989 PAS%2C PAS domain and PF01590 GAF%2C GAF domain gene gene528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0542 SCO0543 SCO0543 SCF11.23 SCF11.23 578092 579228 + peptidase SCF11.23%2C possible peptidase%2C len: 412 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB39706 (EMBL:AL049485) Streptomyces coelicolor peptidase%2C 312 aa%3B fasta scores: opt: 307 z-score: 329.3 E(): 5.7e-11%3B 34.3%25 identity in 201 aa overlap. Contains Pfam match to entry PF01551 peptidase_M37%2C peptidase family M23/M37. Contains possible hydrophobic membrane spanning region gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0543 SCO0544 SCO0544 SCF11.24 SCF11.24 579257 580789 + hypothetical protein SCF11.24%2C hypothetical hypothetical protein%2C len: 510 aa%3B similar to various hypothetical proteins%2C e.g. SW:YM26_MYCTU (EMBL:Z70692) Mycobacterium tuberculosis hypothetical 56.3 KD protein RV2226%2C 513 aa%3B fasta scores: opt: 867 z-score: 952.2 E(): 0%3B 39.0%25 identity in 515 aa overlap. Contains probable N-terminal signal sequence gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0544 SCO0545 SCO0545 SCF11.25 SCF11.25 580913 583459 + hypothetical protein SCF11.25%2C possible hypothetical protein%2C len: 843 aa%3B similar to TR:O87849 (EMBL:AL031013) Streptomyces coelicolor hypothetical protein%2C 602 aa%3B fasta scores: opt: 2859 z-score: 3026.4 E(): 0%3B 72.1%25 identity in 555 aa overlap. Contains possible N-terminal signal sequence gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0545 SCO0546 SCO0546 pyc pyc 583523 586897 - pyruvate carboxylase biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0546 SCO0547 SCO0547 SCF11.27c SCF11.27c 586987 587988 - acyltransferase SCF11.27c%2C possible acyltransferase%2C len: 333 aa%3B similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor multi-domain beta keto-acyl synthase%2C 2082 aa%3B fasta scores: opt: 402 z-score: 416.4 E(): 8e-16%3B 32.5%25 identity in 329 aa overlap%2C and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA%2C 338 aa%3B fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12%3B 33.4%25 identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf%2C acyl transferase domain gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0547 SCO0548 SCO0548 fabB2 fabB2 587985 589271 - 3-oxoacyl-ACP synthase gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0548 SCO0549 SCO0549 SCF11.29c SCF11.29c 589268 589546 - acyl carrier protein gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0549 SCO0550 SCO0550 SCF11.30 SCF11.30 590017 590895 + hypothetical protein SCF11.30%2C possible membrane protein%2C len: 292 aa%3B similar to TR:Q9ZBQ4 (EMBL:AL034447) Streptomyces coelicolor transmembrane protein%2C 396 aa%3B fasta scores: opt: 677 z-score: 505.6 E(): 8.6e-21%3B 43.7%25 identity in 309 aa overlap. Contains possible hydrophobic membrane spanning region gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0550 SCO0551 SCO0551 SCF11.31c SCF11.31c 590981 592309 - histidine kinase SCF11.31c%2C possible histidine kinase%2C len: 442 aa%3B similar to TR:O50497 (EMBL:AL020958) Streptomyces coelicolor two-component system sensor%2C 481 aa%3B fasta scores: opt: 401 z-score: 451.3 E(): 9e-18%3B 30.2%25 identity in 367 aa overlap. Contains Pfam matches to entries PF00512 signal%2C histidine kinase and PF00672 DUF5%2C domain found in bacterial signal proteins. Contains possible N-terminal signal peptide sequence gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0551 SCO0552 SCO0552 SCF11.32c SCF11.32c 592306 593022 - response regulator SCF11.32c%2C possible response regulator%2C len: 238 aa%3B similar to TR:CAB54568 (EMBL:AJ006392) Streptococcus pneumoniae response regulator Rro2%2C 234 aa%3B fasta scores: opt: 583 z-score: 693.9 E(): 2.8e-31%3B 43.2%25 identity in 227 aa overlap. Contains Pfam matches to entries PF00486 trans_reg_C%2C transcriptional regulatory protein and PF00072 response_reg%2C response regulator receiver domain gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0552 SCO0553 SCO0553 SCF11.33c SCF11.33c 593049 593486 - hypothetical protein SCF11.33c%2C unknown%2C len: 145 aa gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0553 SCO0554 SCO0554 manA manA 593641 595338 - beta-mannosidase SCF73.01c%2C manA%2C probable beta-mannosidase%2C len: 327 aa%3B similar to many e.g. MANA_STRLI P51529 mannan endo-1%2C4-beta-mannosidase precursor (EC 3.2.1.78) (363 aa)%2C fasta scores%3B opt: 1189 z-score: 1332.7 E(): 0%2C 61.1%25 identity in 288 aa overlap. Contains N-terminal signal sequence%2C and Pfam match to entry PF00150 cellulase%2C Cellulase (glycosyl hydrolase family 5). Also similar to SC2H4.16 (62.2%25 identity in 288 aa overlap)~SCF11.34c%2C possible sugar hydrolase%2C partial CDS%2C len: >278 aa%3B C-teminus similar to SW:GUN4_THEFU (EMBL:L20093) Thermomonospora fusca endoglucanase E-4 precursor (EC 3.2.1.4) (endo-1%2C4-beta-glucanase E-4)%2C CelD%2C 880 aa%3B fasta scores: opt: 544 z-score: 555.0 E(): 1.5e-23%3B 42.8%25 identity in 215 aa overlap. Contains Pfam matches to entries PF00553 CBD_2%2C cellulose binding domain and PF00041 fn3%2C fibronectin type III domain. Overlaps with Streptomyces coelicolor StF73.01c%2C len: >327 aa%3B C-terminus similar to many e.g. MANA_STRLI P51529 mannan endo-1%2C4-beta-mannosidase precursor (EC 3.2.1.78) (363 aa)%2C fasta scores%3B opt: 1189 z-score: 1332.7 E(): 0%2C 61.1%25 identity in 288 aa overlap. Contains N-terminal signal sequence%2C and Pfam match to entry PF00150 cellulase%2C Cellulase (glycosyl hydrolase family 5) gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0554 SCO0555 SCO0555 SCF73.02c SCF73.02c 595484 597079 - membrane-bound oxidoreductase SCF73.02c%2C possible membrane-bound oxidoreductase%2C len: 531 aa%3B some similarity to eukaryotic molybdenum-containing oxidoreductases e.g. SUOX_RAT Q07116 sulfite oxidase precursor (488 aa)%2C fasta scores%3B opt: 262 z-score: 281.9 E(): 2.5e-08%2C 30.4%25 identity in 319 aa overlap%2C and NIA1_ORYSA nitrate reductase 1 (916 aa)%2C fasta scores%3B opt: 247 z-score: 262.1 E(): 3.1e-07%2C 28.9%25 identity in 336 aa overlap. Contains several membrane spanning hydrophobic domains near N-terminus%2C and Pfam match to entry PF00174 oxidored_molyb%2C Oxidoreductase molybdopterin binding domain gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0555 SCO0556 SCO0556 SCF73.03c SCF73.03c 597132 598655 - hypothetical protein SCF73.03c%2C unknown%2C len: 507 aa gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0556 SCO0557 SCO0557 SCF73.04 SCF73.04 598747 599769 + MerR family transcriptional regulator SCF73.04%2C probable transcriptional regulator%2C len: 340 aa%3B similar in N-terminus to members of the MerR family e.g. NOLA_BRASN nodulation protein NOLA (237 aa)%2C fasta scores%3B opt: 211 z-score: 233.9 E(): 1.2e-05%2C 48.5%25 identity in 68 aa overlap. Also similar to SCD17.06c (34.8%25 identity in 322 aa overlap). Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0557 SCO0558 SCO0558 SCF73.05c SCF73.05c 599712 599978 - hypothetical protein SCF73.05c%2C unknown%2C len: 88 aa gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0558 SCO0559 SCO0559 SCF73.06c SCF73.06c 600051 601052 - hypothetical protein SCF73.06c%2C unknown%2C len: 333 aa gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0559 SCO0560 SCO0560 cpeB cpeB 601133 603355 - catalase/peroxidase SCF73.07c%2C cpeB%2C catalase/peroxidase%2C len: 740 aa%3B highly similar to TR:O87864 (EMBL:Y14317) Streptomyces reticuli catalase/peroxidase (EC 1.11.1.6) (740 aa)%2C fasta scores%3B opt: 4603 z-score: 5243.8 E(): 0%2C 90.5%25 identity in 739 aa overlap%2C and similar to many e.g. CATA_MYCBO peroxidase/catalase (EC 1.11.1.6) (740 aa)%2C fasta scores%3B opt: 3432 z-score: 3909.0 E(): 0%2C 66.7%25 identity in 744 aa overlap. Contains PS00436 Peroxidases active site signature%2C PS00435 Peroxidases proximal heme-ligand signature%2C PS00017 ATP/GTP-binding site motif A (P-loop)%2C and Pfam match to entry PF00141 peroxidase gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0560 SCO0561 SCO0561 furS furS 603385 603840 - Fe regulatory protein SCF73.08c%2C furS%2C Fe regulatory protein%2C len: 151 aa%3B identical to TR:CAB38251 (EMBL:AJ132989) S. coelicolor Fe regulatory protein (151 aa)%2C highly similar to e.g. FUR_MYCTU ferric uptake regulation protein (147 aa)%2C fasta scores%3B opt: 613 z-score: 742.2 E(): 0%2C 64.8%25 identity in 142 aa overlap. Contains Pfam match to entry PF01475 FUR%2C Ferric uptake regulator family gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0561 SCO0562 SCO0562 SCF73.09 SCF73.09 603973 605085 + hypothetical protein SCF73.09%2C probable integral membrane protein%2C len: 370 aa%3B similar to several hypothetical membrane proteins e.g. TR:O06378 (EMBL:) M. tuberculosis Rv3629c (365 aa)%2C fasta scores%3B opt: 439 z-score: 514.5 E(): 2.7e-21%2C 50.5%25 identity in 384 aa overlap gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0562 SCO0563 SCO0563 SCF73.10c SCF73.10c 605122 606555 - hypothetical protein SCF73.10c%2C unknown%2C len: 477 aa%3B similar to TR:Q9RSL6 (EMBL:AE002046) from Deinococcus radiodurans fasta scores%3B opt: 1724%2C Z-score: 1902.8%2C 53.669%25 identity (54.468%25 ungapped) in 477 aa overlap. gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0563 SCO0564 SCO0564 SCF73.11c SCF73.11c 606677 607837 - hypothetical protein SCF73.11c%2C unknown%2C len: 386 aa%3B some similarity to hypothetical protein SC6A5.29 (401 aa)%2C fasta scores%3B opt: 403 z-score: 496.5 E(): 2.7e-20%2C 25.9%25 identity in 347 aa overlap gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0564 SCO0565 SCO0565 SCF73.12c SCF73.12c 607851 608909 - polyprenyl synthetase SCF73.12c%2C probable polyprenyl synthetase%2C len: 352 aa%3B similar to members of the FPP/GGPP synthetases family e.g. GGPP_MYCTU probable geranylgeranyl pyrophosphate synthetase (359 aa)%2C fasta scores%3B opt: 253 z-score: 299.8 E(): 2.5e-09 30.1%25 identity in 346 aa overlap%2C and ISPB_ECOLI octaprenyl-diphosphate synthase (323 aa)%2C fasta scores%3B opt: 222 z-score: 264.3 E(): 2.4e-07%2C 30.0%25 identity in 337 aa overlap. Contains PS00444 Polyprenyl synthetases signature 2%2C and Pfam match to entry PF00348 polyprenyl_synt%2C Polyprenyl synthetases gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0565 SCO0566 SCO0566 SCF73.13c SCF73.13c 608902 609186 - hypothetical protein SCF73.13c%2C probable membrane protein%2C len: 94 aa. Contains possible hydrophobic membrane spanning region gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0566 SCO0567 SCO0567 SC8B3.01 SC8B3.01 609517 610356 + insertion element transposase St8B3.01%2C insertion element transposase%2C len: 279 aa: similar to many e.g. TR:Q9Z9H3 (EMBL:AB024596) from Streptomyces coelicolor fasta scores%3B opt: 1839%2C Z-score: 2145.6%2C 99.642%25 identity (99.642%25 ungapped) in 279 aa overlap. Contains Pfam match to entry PF01675 Transposase_13%2C Transposase and Pfam match to entry PF01511 Transposase_6%2C Transposase. gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0567 SCO0568 SCO0568 SC8B3.02c SC8B3.02c 610415 611488 - polyprenyl synthetase St8B3.02c%2C possible polyprenyl synthetase%2C len: 279 aa: similar to many e.g. TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa) fasta scores%3B opt: 479%2C Z-score: 544.9%2C 36.242%25 identity (38.710%25 ungapped) in 298 aa overlap and SW:P22939 (ISPA_ECOLI) geranyltransferase from Escherichia coli (299 aa) fasta scores%3B opt: 350%2C Z-score: 401.9%2C 31.939%25 identity (34.855%25 ungapped) in 263 aa overlap. Contains Prosite match to PS00723 Polyprenyl synthetases signature 1 and Pfam match to entry PF00348 polyprenyl_synt%2C Polyprenyl synthetase. gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0568 SCO0569 SCO0569 rpmJ rpmJ 611984 612106 - 50S ribosomal protein L36 smallest protein in the large subunit%3B similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc%3B the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion%3B the proteins in this group do not have the motif gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0569 SCO0570 SCO0570 rpmG rpmG 612156 612320 - 50S ribosomal protein L33 in Escherichia coli BM108%2C a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function%3B there are paralogous genes in several bacterial genomes%2C and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31%3B the proteins in this group lack the CXXC motif gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0570 SCO0571 SCO0571 SC5G5.03c SC5G5.03c 612426 613754 - hypothetical protein SC5G5.03c%2C possible peptidase%2C len: 442 aa%3B similar to TR:Q9CC46 (EMBL:AL583921) Mycobacterium leprae possible peptidase ML1288%2C 467 aa%3B fasta scores: opt: 1502 Z-score: 1703.4 bits: 324.4 E(): 2.7e-87%3B 52.874%25 identity in 435 aa overlap and to TR:CAC36379 (EMBL:AL590507) Streptomyces coelicolor peptidase SCI52.18c%2C 445 aa%3B fasta scores: opt: 1590 Z-score: 1803.4 bits: 342.9 E(): 7.5e-93%3B 56.706%25 identity in 425 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20%2C Peptidase family M20/M25/M40 and match to Prosite entry PS00758 ArgE / dapE /%3D possible coiled-coil region at approx. residues 264..283 gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0571 SCO0572 SCO0572 SC5G5.04c SC5G5.04c 613751 615151 - cytosine permease SC5G5.04c%2C probable cytosine permease%2C len: 466 aa%3B similar to SW:CODB_ECOLI (EMBL:X63656) Escherichia coli cytosine permease CodB or B0336%2C 419 aa%3B fasta scores: opt: 509 Z-score: 543.6 bits: 109.7 E(): 1.1e-22%3B 27.427%25 identity in 412 aa overlap. Contains Pfam match to entry PF02133 Transp_cyt_pur%2C Permease for cytosine/purines%2C uracil%2C thiamine%2C allantoin and possible hydrophobic membrane spanning regions gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0572 SCO0573 SCO0573 SC5G5.05c SC5G5.05c 615154 616107 - hypothetical protein SC5G5.05c%2C conserved hypothetical protein%2C len: 317 aa%3B similar to TR:O58746 (EMBL:AP000004) Pyrococcus horikoshii hypothetical 34.0 kDa protein PH1050%2C 315 aa%3B fasta scores: opt: 1322 Z-score: 1394.2 bits: 266.2 E(): 4.6e-70%3B 61.981%25 identity in 313 aa overlap gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0573 SCO0574 SCO0574 SC5G5.06 SC5G5.06 616253 617086 + IclR family regulatory protein SC5G5.06%2C probable IclR-family regulatory protein%2C len: 277 aa%3B similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR or B4018%2C 274 aa%3B fasta scores: opt: 281 Z-score: 332.8 bits: 69.4 E(): 6.1e-11%3B 25.926%25 identity in 243 aa overlap and to SW:GYLR_STRCO (EMBL:X14188) Streptomyces coelicolor glycerol operon regulatory protein GylR or SCI46.03%2C 254 aa%3B fasta scores: opt: 290 Z-score: 343.7 bits: 71.3 E(): 1.5e-11%3B 30.588%25 identity in 255 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0574 SCO0575 SCO0575 SC5G5.07 SC5G5.07 617124 617855 + peptidase E alpha-aspartyl dipeptidase%3B catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue%3B belongs to peptidase S51 family gene gene561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0575 SCO0576 SCO0576 SC5G5.08c SC5G5.08c 617913 618788 - oxidoreductase SC5G5.08c%2C possible oxidoreductase%2C len: 291 aa%3B low similarity to many ketol-acid reductoisomerases%2C e.g. SW:ILVC_METTH (EMBL:AE000905) Methanobacterium thermoautotrophicum ketol-acid reductoisomerase (EC 1.1.1.86) IlvC or MTH1442%2C 333 aa%3B fasta scores: opt: 159 Z-score: 188.7 bits: 43.1 E(): 0.0065%3B 25.301%25 identity in 166 aa overlap gene gene562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0576 SCO0577 SCO0577 SC5G5.09c SC5G5.09c 618788 619588 - hypothetical protein SCF55.01c%2C hypothetical protein%2C len: >231 aa%3B similar to SW:YIHM_ECOLI (EMBL:L19201) Escherichia coli hypothetical 36.9 KD protein in GlnA-Rbn intergenic region%2C 326 aa%3B fasta scores: opt: 188 z-score: 232.7 E(): 1.4e-05%3B 22.1%25 identity in 217 aa overlap~SC5G5.09c%2C conserved hypothetical protein (fragment)%2C len: >92 aa%3B similar to C-terminal region of TR:BAB38218 (EMBL:AP002567) Escherichia coli O157:H7 hypothetical 37.1 kDa protein ECS4795%2C 326 aa%3B fasta scores: opt: 106 Z-score: 142.9 bits: 33.0 E(): 2.4%3B 25.882%25 identity in 85 aa overlap gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0577 SCO0578 SCO0578 SCF55.02c SCF55.02c 619588 620367 - triosephosphate isomerase SCF55.02c%2C possible triosephosphate isomerase%2C len: 259 aa%3B similar to SW:TPIS_MYCTU (EMBL:Z95844) Mycobacterium tuberculosis triosephosphate isomerase (EC 5.3.1.1) TpiA%2C 261 aa%3B fasta scores: opt: 437 z-score: 490.8 E(): 5.8e-20%3B 38.9%25 identity in 221 aa overlap. Contains match to Pfam entry PF00121 TIM%2C Triosephosphate isomerase gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0578 SCO0579 SCO0579 SCF55.03c SCF55.03c 620367 620879 - ribose 5-phosphate isomerase SCF55.03c%2C possible sugar-phosphate isomerase%2C len: 170 aa%3B similar to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) (phosphoriboisomerase B) RpiB%2C 149 aa %3Bfasta scores: opt: 299 z-score: 364.4 E(): 6.3e-13%3B 38.5%25 identity in 148 aa overlap gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0579 SCO0580 SCO0580 SCF55.04c SCF55.04c 620891 622672 - dihydroxyacetone kinase in some organisms the DhaK and DhaL subunits are encoded by separate genes%3B in others they are fused%3B functions along with DhaM to phosphorylate dihydroxyacetone gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0580 SCO0581 SCO0581 SCF55.05c SCF55.05c 622669 624036 - transporter SCF55.05c%2C probable transporter%2C len: 455 aa%3B similar to SW:TUB4_AGRVI (EMBL:U25634) Agrobacterium vitis tartrate transporter Tub4%2C 433 aa%3B fasta scores: opt: 894 z-score: 1016.3 E(): 0%3B 42.8%25 identity in 432 aa overlap and to SW:PHT1_PSEPU (EMBL:D13229) Pseudomonas putida phthalate transporter Pht1%2C 451 aa%3B fasta scores: opt: 745 z-score: 847.5 E(): 0%3B 30.8%25 identity in 435 aa overlap. Contains match to Pfam entry PF00083 sugar_tr%2C Sugar (and other) transporter gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0581 SCO0582 SCO0582 SCF55.06 SCF55.06 624273 625034 + transcriptional regulator SCF55.06%2C possible transcriptional regulator%2C len: 253 aa%3B similar to SW:PDHR_ECOLI (EMBL:V01498) Escherichia coli%2C pyruvate dehydrogenase complex repressor PdhR%2C opt: 292 z-score: 349.5 E(): 4.3e-12%3B 28.6%25 identity in 220 aa overlap. Contains match to Pfam entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0582 SCO0583 SCO0583 SCF55.07 SCF55.07 625127 626350 + cytochrome P450 SCF55.07%2C probable cytochrome P450%2C len: 407 aa%3B similar to SW:Y766_MYCTU (EMBL:Z80226) Mycobacterium tuberculosis cytochrome P450 RV0766c (EC 1.14.-.-) 402 aa %3B fasta scores: opt: 601 z-score: 706.2 E(): 5.8e-32%3B 33.3%25 identity in 403 aa overlap%2C to SWC:PXI_BACME (EMBL:X16610) Bacillus megaterium cytochrome P450(BM-1) (EC 1.14.14.1) Cyp106%2C 410 aa%3B fasta scores: opt: 565 z-score: 664.0 E(): 1.3e-29%3B 30.6%25 identity in 405 aa overlap and to Streptomyces coelicolor SCF55.08c%2C 420 aa%3B fasta scores: opt: 204 z-score: 221.7 E(): 5.2e-07%3B 28.1%25 identity in 417 aa overlap. Contains match to Pfam entry PF00067 p450%2C Cytochrome P450 gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0583 SCO0584 SCO0584 SCF55.08c SCF55.08c 626369 627631 - cytochrome P450 SCF55.08c%2C possible cytochrome P450%2C len: 420 aa%3B similar to TR:O87605 (EMBL:AF087022) Streptomyces violaceus (Streptomyces venezuelae) cytochrome P450 monooxygenase PicK%2C 416 aa%3B fasta scores: opt: 494 z-score: 582.0 E(): 4.8e-25%3B 31.3%25 identity in 416 aa overlap%2C to SW:CPXF_STRGO (EMBL:M32239) Sterptomyces griseolus cytochrome P450-SU2 (EC 1.14.-.-) (P450-CVB1) (CYP105B1)%2C SubC%2C 402 aa%3B fasta scores: opt: 405 z-score: 477.7 E(): 3.1e-19%3B 29.6%25 identity in 412 aa overlap and to Streptomyces coelicolor SCF55.07%2C 407 aa%3B fasta scores: opt: 204 z-score: 217.0 E(): 9.5e-07%3B 27.4%25 identity in 416 aa overlap gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0584 SCO0585 SCO0585 cvnD11 cvnD11 627628 628164 - ATP/GTP binding protein SCF55.09c%2C cvnD11%2C probable ATP/GTP binding protein%2C len: 178 aa%3B similar to TR:CAB41559 (EMBL:AL049727) Streptomyces coelicolor ATP/GTP binding protein%2C SC9B1.13c%2C 181 aa%3B fasta scores: opt: 617 z-score: 780.0 E(): 0%3B 57.5%25 identity in 179 aa overlap and low similarity to SW:YPT1_VOLCA (EMBL:M93438) Volvox carteri GTP binding protein YPTV1%2C 203 aa%3B fasta scores: opt: 117 z-score: 156.9 E(): 0.23%3B 23.2%25 identity in 138 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0585 SCO0586 SCO0586 cvnC11 cvnC11 628247 628588 - hypothetical protein SCF55.10c%2C cvnC11%2C hypothetical protein%2C len: 113 aa%3B similar to various hypothetical proteins%2C e.g: TR:CAB41560 (EMBL:AL049727) Streptomyces coelicolor hypothetical 12.8 KD protein SC9B1.14c%2C 119 aa%3B fasta scores:opt: 264 z-score: 363.7 E(): 7e-13%3B 51.8%25 identity in 112 aa overlap gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0586 SCO0587 SCO0587 cvnB11 cvnB11 628600 629058 - hypothetical protein SCF55.11c%2C cvnB11%2C hypothetical protein%2C len: 152 aa%3B similar to various hypothetical proteins%2C e.g. TR:O86521 (EMBL:AL031124) Streptomyces coelicolor hypothetical 14.7 KD protein SC1C2.20c%2C 140 aa%3B fasta scores: opt: 337 z-score: 422.9 E(): 3.5e-16%3B 41.3%25 identity in 138 aa overlap%2C to TR:CAB41561 (EMBL:AL049727) Streptomyces coelicolor hypothetical 14.4 KD protein SC9B1.15c%2C 139 aa%3B fasta scores: opt: 314 z-score: 395.1 E(): 1.2e-14%3B 41.5%25 identity in 142 aa overlap and to TR:Q9L138 (EMBL:AL158061c) Streptomyces coelicolor hypothetical protein SC6D11.17c%2C 135 aa%3B fasta scores: opt: 634 Z-score: 769.5 E(): 3.1e-35%3B 71.875%25 identity in 128 aa overlap gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0587 SCO0588 SCO0588 cvnA11 cvnA11 629185 630912 - sensor kinase SCF55.12c%2C cvnA11%2C possible sensor kinase%2C len: 575 aa%3B low similarity to C-terminus Streptomyces coelicolor possible sensor kinase SC6G9.44c%2C 806 aa%3B fasta scores: opt: 380 z-score: 360.0 E(): 1.1e-12%3B 25.4%25 identity in 543 aa overlap and to N-terminus TR:CAB41562 (EMBL:AL049727) Streptomyces coelicolor large hypothetical protein SC9B1.16c%2C 877 aa%3B fasta scores: opt: 515 z-score: 485.5 E(): 1.1e-19%3B 31.9%25 identity in 433 aa overlap. Contains match to Pfam entry PF00512 signal%2C Histidine kinase and Prosite entry PS00152 ATP synthase alpha and beta subunits signature. Contains also possible hydrophobic membrane spanning regions gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0588 SCO0589 SCO0589 SCF55.13c SCF55.13c 631216 632103 - LysR family transcriptional regulator SCF55.13c%2C probable lysR-family transcriptional regulator%2C len: 295 aa%3B similar to SW:GLTR_BACSU (EMBL:U79494) Bacillus subtilis transcriptional regulatory protein GltR%2C 296 aa%3B fasta scores: opt: 421 z-score: 502.5 E(): 1.3e-20%3B 33.6%25 identity in 244 aa overlap. Contains match to Pfam entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains possible helix-turn-helix motif at residues 16..37 (+4.59 SD) gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0589 SCO0590 SCO0590 SCF55.14 SCF55.14 632180 633049 + oxidoreductase SCF55.14%2C possible oxidoreductase%2C len: 289 aa%3B similar to various hypothetical proteins%2C e.g. TR:O31570 (EMBL:Z99108) Bacillus subtilis YfhB protein%2C 293 aa%3B fasta scores: opt: 400 z-score: 454.6 E(): 6e-18%3B 32.1%25 identity in 287 aa overlap and low similarity to SW:PHZF_PSEFL (EMBL:L48616) Pseudomonas fluorescens phenazine biosynthesis protein PhzF oxidoreductase%2C 278 aa%3B fasta scores: opt: 225 z-score: 259.7 E(): 4.3e-07%3B 29.3%25 identity in 287 aa overlap gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0590 SCO0591 SCO0591 SCF55.15 SCF55.15 633119 633958 + lysozyme SCF55.15%2C probable lysozyme precursor%2C len: 279 aa%3B similar to SW:LYCM_STRGL (EMBL:M30645) Streptomyces globisporus lysozyme M1 precursor (EC 3.2.1.17) (1%2C4-beta-N-acetylmuramidase M1) Acm%2C 294 aa%3B fasta scores: opt: 837 z-score: 971.2 E(): 0%3B 44.4%25 identity in 284 aa overlap. Contains match to Pfam entry PF01183 Glyco_hydro_25%2C Glycosyl hydrolases family 25 and two matches to Prosite entries PS00953 Glycosyl hydrolases family 25 active sites signature and PS00017 ATP/GTP-binding site motif A (P-loop). Contains also possible N-terminal signal sequence gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0591 SCO0592 SCO0592 SCF55.16c SCF55.16c 633986 634708 - hypothetical protein SCF55.16c%2C unknown%2C len: 240 aa gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0592 SCO0593 SCO0593 SCF55.17c SCF55.17c 634879 635706 - hypothetical protein SCF55.17c%2C unknown%2C len: 275 aa gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0593 SCO0594 SCO0594 SCF55.18c SCF55.18c 635776 636516 - methyltransferase SCF55.18c%2C possible methyltransferase%2C len: 246 aa%3B similar to TR:CAB48912 (EMBL:AL096837) Streptomyces ceolicolor methyltransferase SCF43A.25c%2C 215 aa%3B fasta scores: opt: 190 z-score: 231.6 E(): 1.6e-05%3B 34.9%25 identity in 126 aa overlap and to SW:BIOC_SERMA biotin synthesis protein%2C BioC%2C 255 aa%3B fasta scores: opt: 179 z-score: 217.7 E(): 9.4e-05%3B 32.3%25 identity in 130 aa overlap gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0594 SCO0595 SCO0595 SCF55.19 SCF55.19 636573 637166 + hypothetical protein SCF55.19%2C hypothetical protein%2C len: 197 aa%3B similar to TR:O05917 (EMBL:Z95210) Mycobacterium tuberculosis hypothetical 26.9 KD protein MTCY21C12.19c%2C 245 aa%3B fasta scores: opt: 459 z-score: 543.0 E(): 7.2e-23%3B 39.3%25 identity in 201 aa overlap gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0595 SCO0596 SCO0596 SCF55.20 SCF55.20 637261 637824 + DNA-binding protein SCF55.20%2C probable DNA-binding protein%2C len: 187 aa%3B similar to SW:FTPA_HAEDU (EMBL:U18769) Haemophilus ducreyi fine tangled pili major subunit (24 KD surface protein) FtpA%2C 189 aa%3B fasta scores: opt: 559 z-score: 670.3 E(): 5.8e-30%3B 49.1%25 identity in 171 aa overlap and to SW:DPS_ECOLI (EMBL:X69337) Escherichia coli DNA protection during starvation protein Dps or PexB%2C 166 aa%3B fasta scores: opt: 276 z-score: 338.0 E(): 1.9e-11%3B 34.2%25 identity in 161 aa overlap. Contains match to Prosite entry PS00818 Dps protein family signature 1 gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0596 SCO0597 SCO0597 SCF55.21c SCF55.21c 637911 638306 - hypothetical protein SCF55.21c%2C unknown%2C len: 131 aa%3B sequenced as TR:AAK61188 (EMBL:AF06826) Streptomyces coelicolor A3(2) ORFA%2C 131 aa gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0597 SCO0598 SCO0598 SCF55.22 SCF55.22 638511 638804 + anti anti sigma factor SCF55.22%2C probable anti anti sigma factor%2C len: 97 aa%3B identical to previously sequenced TR:CAB55831 (EMBL:AJ249580) Streptomyces coelicolor anti anti sigma factor%2C 97 aa gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0598 SCO0599 SCO0599 SCF55.23 SCF55.23 638801 639730 + regulator of sig8 SCF55.23%2C probable regulator of sig8%2C 309 aa%3B identical to previously sequenced TR:CAB55832 (EMBL:AJ249580) Streptomyces coelicolor regulator of sig8%2C 309 aa and to TR:Q9ZBT2 (EMBL:AL034446) Streptomyces coelicolor regulatory protein SC1A9.20%2C 153 aa%3B fasta scores: opt: 167 z-score: 197.6 E(): 0.0012%3B 40.4%25 identity in 114 aa overlap gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0599 SCO0600 SCO0600 SCF55.24 SCF55.24 639859 640704 + RNA polymerase sigma factor sig8 SCF55.24%2C sig8%2C len: 266 aa%3B identical to previously sequenced TR:CAB55833 (EMBL:AJ249580) Streptomyces coelicolor Sig8 protein%2C 266 aa and similar to SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma-F factor%2C SigF%2C 287 aa%3B fasta scores: opt: 759 z-score: 872.2 E(): 0%3B 47.6%25 identity in 269 aa overlap and to Streptomyces coelicolor RNA polymerase sigma factor SC5H1.14%2C 295 aa%3B fasta scores: opt: 1265 z-score: 1335.0 E(): 0%3B 73.8%25 identity in 263 aa overlap. Contains match to Pfam entry PF00140 sigma70%2C Sigma-70 factor and to Prosite entry PS00715 Sigma-70 factors family signature 1. Contains also possible helix-turn-helix motif at residues 21702..21767%2C score 2276 (+6.94 SD) gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0600 SCO0601 SCO0601 SCF55.25c SCF55.25c 640719 641762 - hypothetical protein SCF55.25c%2C hypothetical protein%2C len: 347 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB45615 (EMBL:AL079356) Streptomyces coelicolor hypothetical 38.9 KD protein SC6G9.24c%2C 365 aa%3B fasta scores: opt: 621 z-score: 691.9 E(): 3.7e-31%3B 35.8%25 identity in 349 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0601 SCO0602 SCO0602 SCF55.26 SCF55.26 642012 643133 + hypothetical protein SCF55.26%2C hypothetical protein%2C len: aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB42732 (EMBL:AL049826) Streptomyces coelicolor hypothetical 42.9 KD protein SCH24.26c%2C 373 aa%3B fasta scores: opt: 1649 z-score: 1932.2 E(): 0%3B 61.8%25 identity in 374 aa overlap and low similarity to TR:O51533 (EMBL:AE001160) Borrelia burgdoferi FemA protein (FemA) BB0586%2C 347 aa%3B fasta scores: opt: 307 z-score: 363.4 E(): 7.2e-13%3B 27.4%25 identity in 197 aa overlap gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0602 SCO0603 SCO0603 SCF55.27 SCF55.27 643179 643880 + amino transferase SCF55.27%2C probable amino transferase%2C len: 233 aa%3B similar to TR:P95530 (EMBL:D85415) Pseudomonas putida amino group transfer TdnT%2C 253 aa%3B fasta scores: opt: 251 z-score: 300.9 E(): 2.2e-09%3B 31.9%25 identity in 160 aa overlap. Contains match to Pfam entry PF00117 GATase%2C Glutamine amidotransferase class-I and to Prosite entry PS00442 Glutamine amidotransferases class-I active site gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0603 SCO0604 SCO0604 SCF55.28c SCF55.28c 643926 645101 - hypothetical protein SCF55.28c%2C unknown%2C len: 391 aa%3B similar to TR:AAK83171 (EMBL:AF333038) AVIX9 from Streptomyces viridochromogenes. gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0604 SCO0605 SCO0605 SCF55.29 SCF55.29 645297 646232 + AraC family transcription regulator StF55.29%2C probable araC-family transcriptional regulator%2C len: 311 aa%3B similar to TR:CAB46927 (EMBL:AL096822) Streptomyces coelicolor arac-family transcriptional regulator SCGD3.05%2C 334 aa%3B fasta scores: opt: 893 z-score: 1016.6 E(): 0%3B 45.7%25 identity in 315 aa overlap and to SW:RHAS_SALTY (EMBL:X57299) Salmonella typhimurium L-rhamnose operon regulatory protein RhaS%2C 277 aa%3B fasta scores: opt: 234 z-score: 272.8 E(): 8e-08%3B 37.5%25 identity in 96 aa overlap. Contains match to Pfam entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and to Prosite entry PS00041 Bacterial regulatory proteins%2C araC family signature. Contains also a possible helix-turn-helix motif at residues 27077..27142%2C score 1753 (+5.16 SD) gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0605 SCO0606 SCO0606 SCF55.30 SCF55.30 646345 647319 + hypothetical protein StF55.30%2C unknown%2C len: 324 aa. Contains possible coiled-coil at residues 201..313. Max score: 1.838 (probability 1.00) gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0606 SCO0607 SCO0607 SCF55.31 SCF55.31 647444 647731 + lipoprotein SCF55.31 possible lipoprotein%2C len: 112 aa. Contains match to Prosite to entry correctly situated PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0607 SCO0608 SCO0608 SCF55.32 SCF55.32 647887 648765 + regulatory protein StF55.32%2C possible regulatory protein%2C len: 292 aa%3B similar to SW:ALGP_PSEAE (EMBL:M30145) Pseudomonas aeruginosa transcriptional regulatory protein (alginate regulatory protein) AlgP%2C 340 aa%3B fasta scores: opt: 239 z-score: 217.9 E(): 9.1e-05%3B 35.8%25 identity in 193 aa overlap. Contains Lysine/Alanine rich region gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0608 SCO0609 SCO0609 SCF55.33 SCF55.33 648876 649739 + hypothetical protein StF55.33%2C possible integral membrane protein%2C len: 287 aa%3B similar to TR:CAB46783 (EMBL:AL096811) Streptomyces coelicolor integral membrane protein%2C 297 aa%3B fasta scores: opt: 400 z-score: 446.2 E(): 1.8e-17%3B 34.2%25 identity in 278 aa overlap gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0609 SCO0610 SCO0610 SCF55.34 SCF55.34 649840 650610 + GntR family transcriptional regulator SCF55.34%2C possible gntR-family transcriptional regulator%2C len: 256 aa%3B similar to TR:CAB50931 (EMBL:AL096849) Streptomyces coelicolor GntR- family transcriptional regulator%2C 249 aa%3B fasta scores: opt: 328 z-score: 379.5 E(): 9.2e-14%3B 31.6%25 identity in 256 aa overlap and low similarity to SW:FARR_ECOLI (EMBL:X15790) Eschericha coli fatty acyl responsive regulator (P30 PROTEIN) 240 aa%3B fasta scores: opt: 214 z-score: 251.7 E(): 1.2e-06%3B 27.5%25 identity in 211 aa overlap. Contains match to Pfam entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0610 SCO0611 SCO0611 SCF55.35 SCF55.35 650624 651388 + hypothetical protein SCF55.35%2C membrane protein%2C len: 254 aa%3B similar to various hypothetical proteins%2C e.g. TR:O26968 (EMBL:AE000864) Methanobacterium thermoautotrophicum conserved protein MTH882%2C 261 aa%3B fasta scores%3B opt: 202 z-score: 221.3 E(): 5.9e-05%3B 27.4%25 identity in 252 aa overlap gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0611 SCO0612 SCO0612 SCF55.36 SCF55.36 651462 651605 + hypothetical protein SCF55.36%2C hypothetical protein%2C len: 47 aa gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0612 SCO0613 SCO0613 arcA arcA 651602 652864 + arginine deiminase catalyzes the degradation of arginine to citruline and ammonia gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0613 SCO0614 SCO0614 SCF55.38c SCF55.38c 652881 653165 - hypothetical protein SCF55.38c%2C unknown%2C len: 94 aa gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0614 SCO0615 SCO0615 SCF55.39 SCF55.39 653448 653906 + hypothetical protein SCF55.39%2C probable hypothetical protein%2C len: 152 aa. Contains N-terminal region signal peptide sequence gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0615 SCO0616 SCO0616 SCF55.40c SCF55.40c 653947 656322 - hypothetical protein SCF55.40c%2C hypothetical protein%2C len: 791 aa%3B similar to various hypothetical proteins%2C e.g. SW:YK06_MYCTU (EMBL:Z74025) Mycobacterium tuberculosis hypothetical 145.8 KD protein RV2006%2C 1327 aa%3B fasta scores: opt: 2445 z-score: 2870.6 E(): 0%3B 50.0%25 identity in 790 aa overlap gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0616 SCO0617 SCO0617 SCF55.41c SCF55.41c 656319 658772 - phosphoketolase SCF56.01c%2C hypothetical protein (partial CDS)%2C len: >634 aa%3B similar to various hypothetical proteins%2C e.g. TR:P74690 (EMBL:D90917) Synechocystis sp. hypothetical 92.4 kD protein%2C 821 aa%3B fasta scores: opt: 2107 z-score: 2288.7 E(): 0%3B 58.1%25 identity in 513 aa overlap~SCF55.41c%2C hypothetical protein%2C len: 210 aa%3B similar to various hypothetical proteins%2C e.g. TR:P74690 (EMBL:D90917) Synechocystis sp. (strain PCC 6803) hypothetical 92.4 KD protein%2C 821 aa%3B fasta scores: opt: 1405 z-score: 1694.1 E(): 0%3B 56.1%25 identity in 328 aa overlap gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0617 SCO0618 SCO0618 SCF56.02 SCF56.02 659143 660528 + hypothetical protein SCF56.02%2C hypothetical protein%2C len: 461 aa%3B similar to various hypothetical proteins%2C e.g. TR:BAA86645 (EMBL:AB033763) Staphylococcus aureus hypothetical 49.4 kD protein%2C 442 aa%3B fasta scores: opt: 286 z-score: 318.4 E(): 2.3e-10%3B 26.6%25 identity in 466 aa overlap gene gene604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0618 SCO0619 SCO0619 SCF56.03 SCF56.03 660525 661268 + hypothetical protein SCF56.03%2C possible membrane protein%2C len: 247 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB61305 (EMBL:AL132991) Streptomyces coelicolor hypothetical 25.1 kD protein SCF55.35%2C 254 aa%3B fasta scores: opt: 278 z-score: 284.2 E(): 1.9e-08%3B 31.5%25 identity in 251 aa overlap gene gene605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0619 SCO0620 SCO0620 SCF56.04c SCF56.04c 661329 661607 - hypothetical protein SCF56.04c%2C hypothetical protein%2C len: 92 aa%3B similar to various hypothetical proteins%2C e.g. TR:BAA86632 (EMBL:AB033763) Staphylococcus aureus hypothetical 9.9 kD protein%2C 88 aa%3B fasta scores: opt: 203 z-score: 280.2 E(): 3.2e-08%3B 43.7%25 identity in 71 aa overlap gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0620 SCO0621 SCO0621 SCF56.05 SCF56.05 661707 662291 + hypothetical protein SCF56.05%2C hypothetical protein%2C len: 194 aa%3B similar to various hypothetical proteins%2C e.g. SW:YC61_SYNY3 (EMBL:D90909) Synechocystis sp. hypothetical 19.1 kD proetin%2C 179 aa%3B fasta scores: opt: 349 z-score: 408.6 E(): 2.2e-15%3B 41.3%25 identity in 155 aa overlap gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0621 SCO0622 SCO0622 SCF56.06 SCF56.06 662373 663014 + TetR family transcriptional regulator SCF56.06%2C probable tetR-family transcriptional regulator%2C len: 213 aa%3B similar to TR:CAB58268 (EMBL:AL121849) Streptomyces coelicolor tetR family transcriptional regulator SCF6.04%2C 180 aa%3B fasta scores: opt: 240 z-score: 284.5 E(): 1.8e-08%3B 34.5%25 identity in 177 aa overlap and to SW:TCMR_STRG (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR%2C 226 aa%3B fasta scores: opt: 212 z-score: 251.4 E(): 1.3e-06%3B 35.2%25 identity in 182 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 42..63 (+2.60 SD) gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0622 SCO0623 SCO0623 SCF56.07 SCF56.07 663067 664686 + membrane transport protein SCF56.07%2C probable membrane transport protein%2C len: 539 aa%3B similar to TR:Q9X8M3 (EMBL:AL049628) Streptomyces coelicolor exporter SCE94.17c%2C 531 aa%3B fasta scores: opt: 1316 z-score: 1386.9 E(): 0%3B 40.1%25 identity in 534 aa overlap and to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii (Streptomyces alboniger) puromycin resistance protein Pur8%2C 503 aa%3B fasta scores: opt: 701 z-score: 741.2 E(): 0%3B 32.5%25 identity in 434 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0623 SCO0624 SCO0624 SCF56.08c SCF56.08c 664769 665773 - hypothetical protein SCF56.08c%2C possible hypothetical protein%2C len: 334 aa. Contains possible N-terminal region signal peptide sequence gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0624 SCO0625 SCO0625 SCF56.09c SCF56.09c 665816 667096 - transporter SCF56.09c%2C possible transporter%2C len: 426 aa%3B low similarity to TR:Q9ZEJ2 (EMBL:AJ132740) Wolinella succinogenes large integral C4-dicarboxylate membrane transport protein%2C DctM%2C 415 aa%3B fasta scores: opt: 186 z-score: 201.0 E(): 0.00082%3B 23.7%25 identity in 427 aa overlap and to SW:IDNT_ECOLI (EMBL:U14003) Escherichia coli GntII-system L-idonate transporter (L-ido transporter) IdnT%2C 439 aa%3B fasta scores: opt: 176 z-score: 190.3 E(): 0.0032%3B 24.8%25 identity in 432 aa overlap gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0625 SCO0626 SCO0626 SCF56.10c SCF56.10c 667100 667744 - hypothetical protein SCF56.10c%2C unknown%2C len: 214 aa gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0626 SCO0627 SCO0627 SCF56.11c SCF56.11c 667741 669870 - ATP-utilizing protein SCF56.11c%2C possible ATP utilising protein%2C len: 709 aa%3B low similarities to TR:O34180 (EMBL:U95372) Halobacterium volcanii hydantoinase%2C 514 aa%3B fasta scores: opt: 462 z-score: 480.2 E(): 2.3e-19%3B 28.9%25 identity in 575 aa overlap and to SW:OPLA_RAT (EMBL:U70825) Rattus norvegicus 5-oxoprolinase (EC 3.5.2.9)%2C 1288 aa%3B fasta scores: opt: 255 z-score: 261.5 E(): 3.5e-07%3B 26.9%25 identity in 547 aa overlap. Contains match to Prosite entry PS00107 Protein kinases ATP-binding region signature gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0627 SCO0628 SCO0628 SCF56.12c SCF56.12c 669972 671570 - hypothetical protein SCF56.12c%2C possible hypothetical protein%2C len: 532 aa%3B similar to TR:Q55846 (EMBL:D64004) Synechocystis sp. hypothetical 76.4 kD protein%2C 684 aa%3B fasta scores: opt: 236 z-score: 266.6 E(): 1.8e-07%3B 27.3%25 identity in 662 aa overlap gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0628 SCO0629 SCO0629 SCF56.13c SCF56.13c 671618 672727 - transcriptional regulator SCF56.13c%2C possible transcriptional regulator%2C len: 369 aa%3B similar to TR:Q9Z509 (EMBL:AL035591) Streptomyces coelicolor transcriptional regulator (LacI family) SCC54.16%2C 368 aa%3B fasta scores: opt: 367 z-score: 401.8 E(): 5.4e-15%3B 33.2%25 identity in 352 aa overlap and to SW:CCPA_BACME (EMBL:L26052) Bacillus megaterium glucose-resistance amylase regulator CcpA%2C 332 aa%3B fasta scores: opt: 263 z-score: 290.5 E(): 8.4e-09%3B 26.3%25 identity in 339 aa overlap. Contains possible helix-turn-helix motif at residuees 25..46 (+5.42 SD) gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0629 SCO0630 SCO0630 SCF56.14c SCF56.14c 672882 673403 - acetyltransferase SCF56.14c%2C possible acetyltransferase%2C len: 173 aa%3B similar to SW:YJHQ_ECOLI (EMBL:U14003) Escherichia coli hypothetical 20.0 kD protein YjhQ%2C 181 aa%3B fasta scores: opt: 248 z-score: 301.7 E(): 2e-09%3B 36.2%25 identity in 163 aa overlap and weakly similar to SW:PUAC_STRLP (EMBL:M25346) Streptomyces lipmanii (Streptomyces alboniger) puromycin N-acetyltransferase (EC 2.3.-.-) PuaC%2C 199 aa%3B fasta scores: opt: 123 z-score: 155.6 E(): 0.28%3B 31.8%25 identity in 107 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0630 SCO0631 SCO0631 SCF56.15c SCF56.15c 673451 673633 - hypothetical protein SCF56.15c%2C unknown%2C len: 60 aa gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0631 SCO0632 SCO0632 SCF56.16 SCF56.16 673733 674317 + RNA polymerase sigma factor SigK Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B in M. bovis this protein has been shown to be involved in expression of antigenic proteins gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0632 SCO0633 SCO0633 SCF56.17 SCF56.17 674317 675069 + hypothetical protein SCF56.17%2C possible membrane protein%2C len: 250 aa%3B similar to SW:Y24K_STRGR (EMBL:X15060) Streptomyces griseus hypothetical 24.7 kD protein%2C 238 aa%3B fasta scores: opt: 694 z-score: 782.9 E(): 0%3B 53.5%25 identity in 217 aa overlap and to TR:CAB50937 (EMBL:AL096849) Streptomyces coelicolor membrane protein SCI11.11c%2C 250 aa%3B fasta scores: opt: 460 z-score: 522.1 E(): 1.1e-21%3B 42.1%25 identity in 247 aa overlap gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0633 SCO0634 SCO0634 pseudogene pseudogene 675420 676031 - gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0634 SCO0635 SCO0635 SCF56.19 SCF56.19 676130 677023 + hypothetical protein SCF56.19%2C hypothetical protein%2C len: 297 aa%3B similar to TR:Q9XAK3 (EMBL:AL079348) Streptomyces coelicolor hypothetical 33.9 kD protein SC66T3.10c%2C 318 aa%3B fasta scores: opt: 133 z-score: 153.6 E(): 0.36%3B 31.6%25 identity in 212 aa overlap gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0635 SCO0636 SCO0636 SCF56.20 SCF56.20 677227 678861 + ABC transporter ATP-binding protein SCF56.20%2C probable ABC transporter ATP-binding protein%2C len: 544 aa%3B similar to TR:Q9X7M6 (EMBL:AL049587) Streptomyces coelicolor ABC transporter SC5F2A.03c%2C 544 aa%3B fasta scores: opt: 1673 z-score: 1706.2 E(): 0%3B 52.2%25 identity in 542 aa overlap and to SW:MSRA_STAEP (EMBL:X52085) Staphylococcus epidermidis erythromycin resistance ATP-binding protein MsrA%2C 488 aa%3B fasta scores: opt: 351 z-score: 362.8 E(): 7.9e-13%3B 28.6%25 identity in 514 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and two matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0636 SCO0637 SCO0637 SCF56.21 SCF56.21 678937 679392 + hypothetical protein SCF56.21%2C hypothetical protein%2C len: 151 aa%3B similar to TR:O33313 (EMBL:AL008967) Mycobacterium tuberculosis hypothetical 16.0 kD protein MTV002.36c%2C 150 aa%3B fasta scores: opt: 671 z-score: 800.1 E(): 0%3B 67.8%25 identity in 146 aa overlap gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0637 SCO0638 SCO0638 SCF56.22c SCF56.22c 679529 680188 - lipoprotein SCF56.22c%2C possible lipoprotein%2C len: 219 aa%3B similar to TR:O86667 (EMBL:AL031182) Streptomyces coelicolor hypothetical protein SC4A2.11c%2C 220 aa%3B fasta scores: opt: 549 z-score: 568.6 E(): 2.7e-24%3B 45.2%25 identity in 219 aa overlap and to SW:MP83_MYCTU (EMBL:X94597) Mycobacterium tuberculosis cell surface lipoprotein MPT83 precursor%2C 220 aa%3B fasta scores: opt: 497 z-score: 516.2 E(): 2.3e-21%3B 44.8%25 identity in 230 aa overlap. Contains N-terminal region signal peptide sequence and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0638 SCO0639 SCO0639 SCF56.23c SCF56.23c 680496 681428 - hypothetical protein SCF56.23c%2C probable integral membrane protein%2C len: 310 aa%3B similar to TR:O86628 (EMBL:AL031155) Streptomyces coelicolor integral membrane protein SC3A7.27%2C 309 aa%3B fasta scores: opt: 577 z-score: 631.4 E(): 8.7e-28%3B 41.9%25 identity in 298 aa overlap gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0639 SCO0640 SCO0640 SCF56.24c SCF56.24c 681435 681863 - hypothetical protein SCF56.24c%2C hypothetical protein%2C len: 142 aa%3B similar to various hypothetical proteins%2C e.g. TR:O86627 (EMBL:AL031155) Streptomyces coelicolor hypothetical 14.3 kD protein SC3A7.26%2C 129 aa%3B fasta scores: opt: 381 z-score: 485.9 E(): 1.1e-19%3B 55.4%25 identity in 121 aa overlap gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0640 SCO0641 SCO0641 SCF56.25 SCF56.25 681960 682535 + tellurium resistance protein SCF56.25%2C terD%2C tellurium resistance protein (partial CDS)%2C len: >185 aa%3B highly similar to SW:TERD_SERMA (EMBL:L38824) Serratia marcescens tellurium resistance protein TerD%2C 192 aa%3B fasta scores: opt: 876 z-score: 1043.0 E(): 0%3B 70.3%25 identity in 185 aa overlap~SCF91.01%2C terD%2C tellurite resistance protein%2C partial CDS%2C len: > 81 aa. Highly similar to many tellurite resistance proteins including: Serratia marcescens SW:TERD_SERMA(EMBL:L38824) tellurium resistance protein TerD (192 aa)%2C fasta scores opt: 398 z-score: 541.4 E(): 8.8e-23 72.5%25 identity in 80 aa overlap and Escherichia col TR:CAB42998(EMBL:AJ238043) tellurite resistance (192 aa)%2C fasta scores opt: 393 z-score: 534.8 E(): 2e-22 71.3%25 identity in 80 aa overlap. gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0641 SCO0642 SCO0642 SCF91.02c SCF91.02c 682600 684345 - hypothetical protein SCF91.02c%2C unknown%2C len: 581 aa%3B similar to TR:Q983G4 (EMBL:AP003013) from Mesorhizobium loti (559 aa) fasta scores: opt: 1692%2C Z-score: 1945.6%2C 46.277%25 identity (47.283%25 ungapped) in 564 aa overlap. gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0642 SCO0643 SCO0643 SCF91.03c SCF91.03c 684409 685095 - cellulose-binding protein SCF91.03c%2C possible cellulose-binding protein%2C len: 228 aa. Similar to several including: Streptomyces coelicolor TR:CAB50949 (EMBL:AL096849) cellulose-binding protein SCI11.23 (356 aa)%2C fasta scores opt: 349 z-score: 417.9 E(): 6.7e-16 32.2%25 identity in 227 aa overlap. Also weakly similar to chitin-binding proteins e.g. Streptomyces olivaceoviridis TR:Q54501 (EMBL:X78535) chitin binding protein precursor (201 aa)%2C fasta scores opt: 203 z-score: 249.8 E(): 1.5e-06 29.3%25 identity in 222 aa overlap. Contains a possible N-terminal signal sequence. gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0643 SCO0644 SCO0644 SCF91.04c. SCF91.04c. 685288 687444 - hypothetical protein SCF91.04c%2C possible membrane protein%2C len: 729 aa. Contains possible membrane spanning hydrophobic domain%2C a possible N-terminal signal sequence and a PS00216 Sugar transport proteins signature 1. Also contains a probable coiled-coil from 76 to 107 (32 residues). gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0644 SCO0645 SCO0645 SCF91.05c. SCF91.05c. 687554 688567 - Zinc-containing dehydrogenase SCF91.05c%2C possible Zinc-containing dehydrogenase%2C len: 337 aa. Similar to many dehydrogenases including: Alcaligenes eutrophus SW:ADH_ALCEU(EMBL:J03362) alcohol dehydrogenase (EC 1.1.1.1) (366 aa)%2C fasta scores opt: 272 z-score: 296.1 E(): 4e-09 27.0%25 identity in 371 aa overlap and Streptomyces coelicolor TR:Q53927(EMBL:X62373) hydroxyacyl-CoA dehydrogenase (329 aa)%2C fasta scores opt: 308 z-score: 335.0 E(): 2.8e-11 31.8%25 identity in 333 aa overlap. Contains a Prosite hit to PS00059 Zinc-containing alcohol dehydrogenases signature and a Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0645 SCO0646 SCO0646 SCF91.06 SCF91.06 688679 689263 + TetR family transcriptional regulator SCF91.06%2C possible TetR-family transcriptional regulator%2C len: 194 aa. Similar to many regulators e.g. Propionibacterium freudenreichii TR:P72185( EMBL:U51164) repressor protein (HemR protein) (259 aa)%2C fasta scores opt: 249 z-score: 304.0 E(): 1.5e-09 33.8%25 identity in 142 aa overlap. Also similar to several Streptomyces coelicolor regulators e.g. TR:CAB56137 (EMBL:AL117669) SCF12.11 (206 aa)%2C fasta scores opt: 337 z-score: 409.5 E(): 2e-15 36.7%25 identity in 196 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 39..60 (+3.20 SD). gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0646 SCO0647 SCO0647 SCF91.07 SCF91.07 689364 690161 + short chain oxidoreductase SCF91.07%2C probable short chain oxidoreductase%2C len: 265 aa. Highly similar to many e.g. Klebsiella aerogenes SW:RIDH_KLEAE (EMBL:M25606) ribitol 2-dehydrogenase (EC 1.1.1.56) (249 aa)%2C fasta scores opt: 311 z-score: 345.7 E(): 7e-12 31.7%25 identity in 230 aa overlap and Mycobacterium avium TR:AAD20367 (EMBL:AF125999) dehydrogenase (259 aa)%2C fasta scores opt: 897 z-score: 975.2 E(): 0 56.8%25 identity in 257 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0647 SCO0648 SCO0648 SCF91.08. SCF91.08. 690228 690923 + methyltransferase SCF91.08%2C possible methyltransferase%2C len: 231 aa. Similar in parts to several including: Streptomyces avermitilis TR:BAA84602(EMBL:AB032524) C5-O-methyltransferase (283 aa)%2C fasta scores opt: 243 z-score: 292.9 E(): 6.1e-09 34.5%25 identity in 168 aa overlap and Streptomyces lavendulae TR:AAD28458(EMBL:AF127374) methyltransferase (275 aa)%2C fasta scores opt: 235 z-score: 283.7 E(): 2e-08 32.9%25 identity in 167 aa overlap. gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0648 SCO0649 SCO0649 gvpO2. gvpO2. 690966 691283 + gas vesicle synthesis protein SCF91.09%2C gvpO2%2C possible gas vesicle synthesis protein%2C len: 105 aa. Similar in parts to several other gas vesicle synthesis proteins including: Halobacterium salinarium SW:GVO2_HALSA (EMBL:X64730) gas vesicle synthesis protein protein%2C chromosomal (111 aa)%2C fasta scores opt: 205 z-score: 272.6 E(): 8.2e-08 39.0%25 identity in 77 aa overlap and Streptomyces coelicolor TR:Q9ZC14 (EMBL:AL033505) gas vesicle synthesis protein GvpO (130 aa)%2C fasta scores opt: 223 z-score: 294.0 E(): 5.3e-09 48.7%25 identity in 76 aa overlap. gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0649 SCO0650 SCO0650 gvpA2 gvpA2 691320 691832 + gas vesicle synthesis-like protein similar to the gas vesicle synthesis protein GvpA in other bacteria but contains an extended C-terminal tail%3B function in the Streptomyces group is unknown but they contain several homologs of other gas vesicle synthesis proteins gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0650 SCO0651 SCO0651 gvpF2 gvpF2 691829 692614 + gas vesicle synthesis protein SCF91.11%2C gvpF2%2C possible gas vesicle synthesis protein%2C len: 261 aa. Highly similar to many other gas vesicle synthesis proteins including: Bacillus megaterium TR:O68674(EMBL:AF053765) gas vesicle protein GvpF (255 aa)%2C fasta scores opt: 181 z-score: 209.5 E(): 0.00027 24.2%25 identity in 211 aa overlap and Streptomyces coelicolor TR:Q9ZC12 (EMBL:AL033505) gas vesicle synthesis protein GvpF (257 aa)%2C fasta scores opt: 459 z-score: 515.7 E(): 2.4e-21 38.9%25 identity in 244 aa overlap. gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0651 SCO0652 SCO0652 gvpG2 gvpG2 692619 692897 + gas vesicle synthesis protein SCF91.12%2C gvpG2%2C possible gas vesicle synthesis protein%2C len: 92 aa. Similar to Bacillus megaterium TR:O68673(EMBL:AF053765) gas vesicle protein GvpG (88 aa)%2C fasta scores opt: 108 z-score: 155.4 E(): 0.28 31.7%25 identity in 63 aa overlap and Streptomyces coelicolor TR:Q9ZC11 (EMBL:AL033505) gas vesical synthesis protein GvpG (87 aa)%2C fasta scores opt: 216 z-score: 290.9 E(): 7.9e-09 43.7%25 identity in 87 aa overlap. Contains a probable coiled-coil from 40 to 67 (28 residues). gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0652 SCO0653 SCO0653 SCF91.13 SCF91.13 692894 693445 + hypothetical protein SCF91.13%2C unknown%2C len: 183 aa. Similar to two proteins of unknown function from Streptomyces coelicolor TR:CAB44390(EMBL:AL078610) SCH35.37C (199 aa)%2C fasta scores opt: 378 z-score: 365.6 E(): 5.5e-13 38.3%25 identity in 196 aa overlap and TR: Q9ZC10(EMBL:AL033505) SC1E6.12 (239 aa)%2C fasta scores opt: 327 z-score: 317.7 E(): 2.6e-10 35.1%25 identity in 228 aa overlap. gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0653 SCO0654 SCO0654 SCF91.14 SCF91.14 693442 694416 + hypothetical protein SCF91.14%2C unknown%2C len: 324 aa. Highly similar to several proteins of undefined function from Streptomyces coelicolor including TR:CAB44391 (EMBL:AL078610) SCH35.36C (320 aa)%2C fasta scores opt: 1125 z-score: 985.2 E(): 0 57.4%25 identity in 305 aa overlap and TR:Q9ZC09 (EMBL:AL033505) SC1E6.13 (3376 aa)%2C fasta scores opt: 934 z-score: 819.6 E():0 50.4%25 identity in 337 aa overlap. Contains a probable coiled-coil from residue 249 to 287 (39 residues) gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0654 SCO0655 SCO0655 gvpJ2 gvpJ2 694441 694785 + gas vesicle synthesis protein SCF91.15%2C gvpJ2%2C possible gas vesicle synthesis protein%2C len: 114 aa. Highly similar to many other gas vesicle synthesis proteins including: Bacillus megaterium TR:O6869(EMBL:AF053765) gas vesicle protein GvpJ (100 aa)%2C fasta scores opt: 337 z-score: 453.5 E(): 7e-18 58.8%25 identity in 85 aa overlap and Streptomyces coelicolor TR:Q9ZC08 (EMBL:AL033505) gas vesicle synthesis protein GvpJ (109 aa)%2C fasta scores opt: 423 z-score: 564.4 E(): 4.6e-24 69.8%25 identity in 96 aa overlap. Contains a Pfam match to entry PF00741 Gas_vesicle%2C Gas vesicle protein and a Prosite hit to PS00234 Gas vesicles protein GVPa signature 1. Also contains a probable coiled-coil from 78 to 114 (37 residues). gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0655 SCO0656 SCO0656 gvpL2 gvpL2 694782 695624 + gas vesicle synthesis protein SCF91.16%2C gvpL2%2C possible gas vesicle synthesis protein%2C len: 280 aa. Weakly similar to Bacillus megaterium TR:O6872 (EMBL:AF053765) gas vesicle protein GvpL (269 aa)%2C fasta scores opt: 172 z-score: 189.1 E(): 0.0037 19.8%25 identity in 222 aa overlap. Also similar to Streptomyces coelicolor TR:Q9ZC07 (EMBL:AL033505) gas vesicle synthesis protein GvpL (259 aa)%2C fasta scores opt: 436 z-score: 462.0 E(): 2.3e-18 37.0%25 identity in 254 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0656 SCO0657 SCO0657 gvpS2 gvpS2 695660 695869 + gas vesicle synthesis protein SCF91.17%2C gvpS2%2C possible gas vesicle synthesis protein%2C len: 69 aa. Highly similar to Bacillus megaterium TR:O6869(EMBL:AF053765) gas vesicle protein GvpS (95 aa)%2C fasta scores opt: 143 z-score: 203.5 E(): 0.00059 39.3%25 identity in 56 aa overlap and Streptomyces coelicolor TR:Q9ZC06 (EMBL:AL033505) gas vesicle synthesis protein GvpS (60 aa)%2C fasta scores opt: 214 z-score: 298.0 E(): 3.2e-09 63.5%25 identity in 52 aa overlap. Contains a possible membrane spanning hydrophobic domain and a Pfam match to entry PF00741 Gas_vesicle%2C Gas vesicle protein. gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0657 SCO0658 SCO0658 gvpK2 gvpK2 695866 696168 + gas vesicle synthesis protein SCF91.18%2C gvpK2%2C possible gas vesicle synthesis protein%2C len: 100 aa. Highly similar to many other gas vesicle synthesis proteins including: Halobacterium salinarium SW:GVK2_HALSA(EMBL:X64730) gas vesicle synthesis protein GvpK (119 aa)%2C fasta scores opt: 163 z-score: 224.6 E(): 3.9e-05 43.3%25 identity in 67 aa overlap and Bacillus megaterium TR:O68670(EMBL:AF053765) gas vesicle protein GvpK (94 aa)%2C fasta scores opt: 302 z-score: 402.9 E(): 4.6e-15 53.3%25 identity in 92 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9ZC05 (EMBL:AL033505) gas vesicle synthesis protein GvpK (98 aa)%2C fasta scores opt: 370 z-score: 489.0 E(): 7.3e-20 66.3%25 identity in 92 aa overlap. gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0658 SCO0659 SCO0659 SCF91.19 SCF91.19 696248 697354 + DeoR family transcriptional regulator SCF91.19%2C possible DeoR-family transcriptional regulator%2C len: 368 aa. Similar to many DNA-binding regulatory proteins including: Streptomyces reticuli TR:CAB46346(EMBL:AJ009798) regulator CebR (350 aa)%2C fasta scores opt: 287 z-score: 337.9 E(): 1.9e-11 30.6%25 identity in 359 aa overlap and Streptomyces lividans SW:REGL_STRLI (EMBL:X98242) transcription regulatory protein RegL (345 aa)%2C fasta scores opt: 276 z-score: 325.3 E(): 9.6e-11 28.9%25 identity in 353 aa overlap. Contains Pfam matches to entries PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family and Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family. In addition to a Prosite hit to PS00894 Bacterial regulatory proteins%2C deoR family signature with the helix-turn-helix motif situated between residues 23..44 (+3.43 SD). Also contains a probable coiled-coil from 21 to 48 (28 residues). gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0659 SCO0660 SCO0660 SCF91.20 SCF91.20 697480 698811 + solute-binding lipoprotein SCF91.20%2C probable solute-binding lipoprotein%2C len: 443 aa. Similar to several solute-binding proteins e.g. Agrobacterium radiobacter SW:LACE_AGRRD(EMBL:X66596) lactose-binding protein precursor (422 aa)%2C fasta scores opt: 270 z-score: 303.1 E(): 1.6e-09 23.5%25 identity in 387 aa overlap and Streptomyces coelicolor TR:P72397(EMBL:Y07706) maltose-binding protein MalE (423 aa)%2C fasta scores opt: 345 z-score: 386.1 E(): 4e-14 25.5%25 identity in 459 aa overlap. Contains a Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein. Also contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0660 SCO0661 SCO0661 SCF91.21 SCF91.21 698838 699824 + binding protein dependent transport protein SCF91.21%2C possible binding protein dependent transport protein%2C len: 328 aa. Similar to many membrane transport proteins e.g. Escherichia coli SW:UGPA_ECOLI(EMBL:X13141) SN-glycerol-3-phosphate transport system permease (295 aa)%2C fasta scores opt: 393 z-score: 465.7 E(): 1.5e-18 28.7%25 identity in 282 aa overlap and Streptomyces coelicolor TR:CAB41203(EMBL:AL049661) binding protein dependent transport protein (327 aa)%2C fasta scores opt: 452 z-score: 533.8 E(): 2.4e-22 28.2%25 identity in 326 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and multiple possible membrane spanning hydrophobic domains. gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0661 SCO0662 SCO0662 SCF91.22 SCF91.22 699821 700684 + binding protein dependent transport protein SCF91.22%2C possible binding protein dependent transport protein%2C len: 287 aa. Similar to many membrane transport proteins e.g. Agrobacterium radiobacter SW:LACG_AGRRD(EMBL:X66596) lactose transport system permease (273 aa)%2C fasta scores opt: 439 z-score: 546.1 E(): 4.8e-23 28.5%25 identity in 267 aa overlap and Bacillus subtilis TR:O05095(EMBL:X89810) integral protein (281 aa)%2C fasta scores opt: 480 z-score: 596.3 E(): 7.7e-26 30.8%25 identity in 266 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and multiple possible membrane spanning hydrophobic domains. gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0662 SCO0663 SCO0663 SCF91.23 SCF91.23 700681 701712 + 2-hydroxyacid dehydrogenase SCF91.23%2C possible 2-hydroxyacid-family dehydrogenase%2C len: 343 aa. Similar in parts to several D-3-phosphoglycerate dehydrogenases e.g. Mycobacterium tuberculosis SW:SERA_MYCTU (EMBL:AL021287) (528 aa)%2C fasta scores opt: 450 z-score: 536.4 E(): 1.7e-22 34.1%25 identity in 261 aa overlap. Also similar to Streptomyces coelicolor TR:CAB55710(EMBL:AL117387) possible dehydrogenase SCF41.07 (339 aa)%2C fasta scores opt: 927 z-score: 1106.0 E(): 0 48.6%25 identity in 325 aa overlap. Contains a Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases and a Prosite hit to PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0663 SCO0664 SCO0664 SCF91.24 SCF91.24 701709 703604 + hypothetical protein SCF91.24%2C hypothetical protein%2C len: 631 aa%3B similar to TR:CAC48915 (EMBL:AL603643) Rhizobium meliloti (Sinorhizobium meliloti) hypothetical protein SMB20536%2C 617 aa%3B fasta scores: opt: 524 Z-score: 553.7 E(): 3.3e-23%3B 30.182%25 identity in 550 aa overlap gene gene650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0664 SCO0665 SCO0665 SCF91.25 SCF91.25 703750 703977 + hypothetical protein SCF91.25%2C possible hypothetical protein%2C len: 75 aa. Contains a possible N-terminal signal sequence. gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0665 SCO0666 SCO0666 catB catB 704114 706393 + catalase SCF91.26%2C catB%2C catalase (EC 1.11.1.6)%2C len: 759 aa. Previously sequenced and characterised from Streptomyces coelicolor strain ATCC10147 EMBL:AF000419 fasta scores opt:5163 z-score:0.0 E(): 0.0 100.00%25 identity in 759 aa overlap. Contains two Prosite hits to PS00437 Catalase proximal heme-ligand signature and PS00438 Catalase proximal active site signature. Also contains a Pfam match to entry PF00199 catalase%2C Catalase. gene gene652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0666 SCO0667 SCO0667 SCF91.27c SCF91.27c 706448 707329 - hypothetical protein SCF91.27c%2C hypothetical protein%2C len: 293 aa. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:O53526(EMBL:AL021925) hypothetical 32.8 KD protein (309 aa)%2C fasta scores opt: 441 z-score: 476.5 E(): 3.6e-19 32.8%25 identity in 299 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0667 SCO0668 SCO0668 SCF91.28c SCF91.28c 707401 708993 - flavoprotein SCF91.28c%2C possible flavoprotein%2C len: 530 aa. Highly similar to two hypothetical proteins from Mycobacterium tuberculosis e.g. TR:O53525 (EMBL:AL021925) hypothetical 49.8 KD protein (457 aa)%2C fasta scores opt: 1698 z-score: 1838.9 E():0 57.7%25 identity in 461 aa overlap. Also similar to several eukaryotic alkyldihydroxyacetonephosphate synthases (EC 2.5.1.26) e.g. from Homo sapiens (Human) SW:ADAS_HUMAN (EMBL:Y09443) (658 aa)%2C fasta scores opt: 598 z-score: 648.1 E(): 1e-28 30.4%25 identity in 573 aa overlap. Contains a Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain. gene gene654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0668 SCO0669 SCO0669 SCF91.29 SCF91.29 709071 709688 + TetR family transcriptional regulator SCF91.29%2C possible TetR-family transcriptional regulator%2C len: 205 aa. Weakly similar to many other regulators e.g. Streptomyces hygroscopicus TR:Q54288 (EMBL:X86780) regulator of antibiotic transport complexes (204 aa)%2C fasta scores opt: 148 z-score: 192.6 E(): 0.0024 29.6%25 identity in 115 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 37..58 (+5.86 SD). gene gene655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0669 SCO0670 SCO0670 glpD glpD 709685 711268 + glycerol-3-phosphate dehydrogenase SCF91.30%2C glpD%2C glycerol-3-phosphate dehydrogenase (EC 1.1.99.5)%2C len: 527 aa. Highly similar to many prokaryotic and eukaryotic glycerol-3-phosphate dehydrogenases including: Mycobacterium tuberculosis SW:GLPD_MYCTU (EMBL:Z70692) (516 aa)%2C fasta scores opt: 1648 z-score: 1727.9 E():0 52.6%25 identity in 513 aa overlap and Caenorhabditis elegans SW:GPDM_CAEEL(EMBL:Z73906) (722aa)%2C fasta score opt: 668 z-score: 700.9 E(): 1.2e-31 33.9%25 identity in 537 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh%2C FAD-dependent glycerol-3-phosphate dehydrogenase and a Prosite hit to PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0670 SCO0671 SCO0671 SCF91.31c SCF91.31c 711379 711633 - hypothetical protein SCF91.31c%2C unknown%2C len: 84 aa. gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0671 SCO0672 SCO0672 SCF91.32 SCF91.32 711649 712200 + anti-sigma factor antagonist SCF91.32%2C possible anti-sigma factor antagonist%2C len: 183 aa. Similar in parts to many anti-sigma factor antagonists including: Streptomyces coelicolor TR:CAB44395 (EMBL:AL078610) SCH35.32C (113 aa)%2C fasta scores opt: 199 z-score: 246.4 E(): 2.4e-06 33.9%25 identity in 112 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA. gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0672 SCO0673 SCO0673 SCF91.33c SCF91.33c 712209 712736 - hypothetical protein SCF91.33c%2C unknown%2C len: 175 aa. Weakly similar to several regulatory proteins including: Streptomyces coelicolor TR:CAB42940(EMBL:AL049863) SC5H1.15C (151 aa)%2C fasta scores opt: 235 z-score: 290.0 E(): 8.9e-09 39.3%25 identity in 122 aa overlap. gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0673 SCO0674 SCO0674 xysA xysA 712829 714181 - endo-1%2C4-beta-xylanase SCF91.34c%2C xysA%2C endo-1%2C4-beta-xylanase (EC 3.2.1.8)%2C len: 450 aa. Highly similar to many including: Streptomyces lividans SW:XYNA_STRLI(EMBL:M64551) endo-1%2C4-beta-xylanase A precursor (EC 3.2.1.8) (477 aa)%2Cfasta scores opt: 1313 z-score: 1280.4 E(): 0 49.0%25 identity in 459 aa overlap and Streptomyces halstedii TR:Q59922(EMBL:U41627) endo-1%2C4-beta-xylanase (EC 3.2.1.8) (461 aa)%2C fasta scores opt: 2301 z-score: 2238.0 E():0 76.9%25 identity in 438 aa overlap. Contains Pfam matches to entries PF00553 CBD_2%2C Cellulose binding domain and Pfam match to entry PF00331 Glyco_hydro_10%2C Glycosyl hydrolase family 10. Also contains a Prosite hit to PS00591 Glycosyl hydrolases family 10 active site and a possible N-terminal signal sequence. gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0674 SCO0675 SCO0675 SCF91.35 SCF91.35 714374 717028 + hypothetical protein SCF91.35%2C unknown%2C len: 884 aa. Similar to several Streptomyces coelicolor proteins e.g. TR:O86807 (EMBL:AL031031) regulatory protein SC7C7.02C (916 aa)%2C fasta scores opt: 351 z-score: 351.3 E(): 3.4e-12 26.9%25 identity in 815 aa overlap and TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein SC9C7.20 (860 aa)%2C fasta scores opt: 579 z-score: 580.5 E(): 5.8e-25 30.5%25 identity in 731 aa overlap. Also similar in the C-terminus to several other regulatory proteins e.g. Synechocystis sp. (strain PCC 6803) TR:P73256 (EMBL:D90905) sigma factor SibG regulation protein RsbU (452 aa)%2C fasta scores opt: 240 z-score: 244.4 E(): 3.1e-06 26.7%25 identity in 363 aa overlap. Contains a Pfam match to entry PF01590 GAF%2C GAF domain. gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0675 SCO0676 SCO0676 SCF91.36 SCF91.36 717303 719897 + integral membrane sensor protein SCF91.36%2C possible integral membrane sensor protein%2C len: 864 aa. Similar in the N-terminus to several sensory transduction histidine kinases e.g. Escherichia coli SW:DCUS_ECOLI(EMBL:U14003) sensor protein DcuS (EC 2.7.3.-) (543 aa)%2C fasta scores opt: 499 z-score: 546.9 E(): 4.4e-23 30.8%25 identity in 331 aa overlap. Highly similar in the C-terminus to several proteins from Streptomyces coelicolor including: TR:CAB41270(EMBL:AL049707) conserved hypothetical protein (fragment) ( >436 aa)%2C fasta scores opt: 1207 z-score: 1324.9 E():0 48.0%25 identity in 423 aa overlap and TR:CAB44394(EMBL:AL078610) regulatory protein SCH35.33C (422 aa)%2C fasta scores opt: 309 z-score: 340.2 E(): 1.4e-11 32.0%25 identity in 284 aa overlap. Contains a Pfam match to entry PF01590 GAF%2C GAF domain. Also contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0676 SCO0677 SCO0677 csn csn 720032 720874 + chitosanase SCF91.37%2C csn%2C chitosanase (EC 3.2.1.132)%2C len: 280 aa. Highly similar to several including: Streptomyces sp. (strain N174) SW:CHIS_STRSQ (EMBL:L07779) chitosanase precursor (EC 3.2.1.132) (278 aa)%2C fasta scores opt: 1122 z-score: 1263.9 E():0 64.3%25 identity in 272 aa overlap and Streptomyces coelicolor TR:CAB52859 (EMBL:AL109849) chitosanase (305 aa)%2C fasta scores opt: 954 z-score: 1075.3 E():0 63.7%25 identity in 234 aa overlap. Contains a Pfam match to entry PF01374 Glyco_hydro_46%2C Glycosyl hydrolase family 46 and a possible N-terminal signal sequence. gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0677 SCO0678 SCO0678 SCF91.38c SCF91.38c 720985 721158 - hypothetical protein SCF91.38c%2C unknown%2C len: 57 aa. Similar to Bacillus subtilis TR:P70964(EMBL:Z81356) hypothetical 6.8 KD protein (62 aa)%2C fasta scores opt: 104 z-score: 152.5 E(): 0.4 33.3%25 identity in 57 aa overlap. gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0678 SCO0679 SCO0679 SCF91.39 SCF91.39 721248 721463 + hypothetical protein SCF91.39%2C unknown%2C len: 71 aa. gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0679 SCO0680 SCO0680 SCF15.01c SCF15.01c 721495 723039 - transmembrane efflux protein SCF15.01c%2C possible transmembrane efflux protein%2C partial CDS%2C len: > 443 aa. Highly similar to many members of the drug resistance translocase family including: Streptomyces lipmanii (Streptomyces alboniger) SW:PUR8_STRLP(EMBL:X76855) puromycin resistance protein Pur8 (503 aa)%2C fasta scores opt: 902 z-score: 986.1 E():0 42.6%25 identity in 420 aa overlap and Streptomyces coelicolor SW:AC22_STRCO(EMBL:M64683) probable actinorhodin transporter ActII-2 (578 aa)%2C fasta scores opt: 867 z-score: 947.3 E():0 39.6%25 identity in 417 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and multiple possible membrane spanning hydrophobic domains.~SCF91.40c%2C possible transmembrane efflux protein%2C partial CDS%2C len: > 105 aa. Similar to Streptomyces coelicolor TR:CAB42035(EMBL:AL049754) transmembrane efflux protein SCH10.26C (484 aa)%2C fasta scores pt: 111 z-score: 141.1 E():1.7 31.4%25 identity in 105 aa overlap. Contains a possible membrane spanning hydrophobic domain. Overlaps and extends into CDS SCF15.01c on the adjoining cosmid. gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0680 SCO0681 SCO0681 SCF15.02 SCF15.02 723181 724545 + ferredoxin/ferredoxin-NADP reductase SCF15.02%2C possible ferredoxin/ferredoxin-NADP reductase (hypothetical protein)%2C len: 454 aa. Similar to several eukaryotic and prokaryotic ferredoxin-NADP(+) reductases e.g. Rattus norvegicus (Rat) SW:ADRO_RAT (EMBL:D63761) NADPH:adrenodoxin oxidoreductase precursor (EC 1.18.1.2) (494 aa)%2C fasta scores opt: 780 z-score: 902.2 E(): 0 36.3%25 identity in 463 aa overlap and Mycobacterium leprae TR:O32886 (EMBL:Z98271) possible ferredoxin (456 aa)%2C fasta scores opt: 1030 z-score: 1191.5 E():0 39.2%25 identity in 454 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0681 SCO0682 SCO0682 SCF15.03c SCF15.03c 724639 725013 - hypothetical protein SCF15.03c%2C unknown%2C len: 124 aa. Contains a probable coiled-coil between residues 96..124 (29 residues). gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0682 SCO0683 SCO0683 SCF15.04c SCF15.04c 725056 725580 - hypothetical protein SCF15.04c%2C hypothetical protein%2C len: 174 aa. Weakly similar to several conserved proteins of undefined function e.g. Methanococcus jannaschii SW:Y714_METJA(EMBL:U67518) hypothetical protein (118 aa)%2C fasta scores opt: 182 z-score: 196.7 E(): 0.0014 30.4%25 identity in 115 aa overlap. gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0683 SCO0684 SCO0684 SCF15.05c SCF15.05c 725619 726395 - hypothetical protein SCF15.05c%2C unknown%2C len: 258 aa. gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0684 SCO0685 SCO0685 SCF15.06c SCF15.06c 726401 726808 - hypothetical protein SCF15.06c%2C unknown%2C len: 135 aa. gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0685 SCO0686 SCO0686 SCF15.07 SCF15.07 726845 728068 + hypothetical protein SCF15.07%2C possible membrane protein%2C 407 aa. Similar in parts to several hypothetical proteins e.g. Bacillus subtilis TR:O34437(EMBL:Z99108) hypothetical YfkH protein (275 aa)%2C fasta scores: opt: 542 z-score: 589.5 E(): 1.8e-25 32.0%25 identity in 284 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0686 SCO0687 SCO0687 SCF15.08c SCF15.08c 728130 728924 - oxidoreductase SCF15.08c. probable oxidoreductase%2C len: 264 aa. Similar to many including: Escherichia coli SW:UCPA_ECOLI (EMBL:AE000330) oxidoreductase UcpA (EC 1.-.-.-) (285 aa)%2C fasta scores opt: 344 z-score: 389.1 E(): 2.7e-14 33.2%25 identity in 268 aa overlap and Streptomyces coelicolor TR:CAB55718 (EMBL:AL117387) probable oxidoreductase SCF41.15 (263 aa)%2C fasta scores opt: 418 z-score: 471.2 E(): 7.1e-19 36.5%25 identity in 255 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. In addition to a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0687 SCO0688 SCO0688 SCF15.09 SCF15.09 729117 730289 + hypothetical protein SCF15.09%2C unknown%2C len: 390 aa. Contains a probable coiled-coil between residues 285..329 (45 residues). gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0688 SCO0689 SCO0689 SCF15.10 SCF15.10 730352 730987 + oxidoreductase%2C iron-sulfur binding subunit SCF15.10%2C possible oxidoreductase%2C iron-sulphur binding subunit%2C len: 187 aa. Similar to many multipartite proteins including: the small subunit of quinoline 2-oxidoreductase from Pseudomonas putida TR:P72223(EMBL:X98131) QorS (168 aa)%2C fasta scores opt: 371 z-score: 438.8 E(): 4.6e-17 44.7%25 identity in 170 aa overlap and Acetobacter europaeus TR:O30328(EMBL:Y08696) aldehyde dehydrogenase subunit III precursor (157 aa)%2C fasta scores opt: 309 z-score: 367.9 E(): 4e-13 39.3%25 identity in 163 aa overlap. Also similar to the N-terminal iron-sulphur binding domain of Rhodobacter capsulatus (Rhodopseudomonas capsulata) TR:O54050(EMBL:AJ001013) xanthine dehydrogenase (EC 1.1.1.204) (462 aa)%2C fasta scores opt: 299 z-score: 349.6 E(): 4.2e-12 37.2%25 identity in 164 aa overlap. Contains Pfam matches to entries PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains and PF01799 fer2_2%2C 2Fe-2S iron-sulfur cluster binding domains. Also contains Prosite hits to PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature and PS00070 Aldehyde dehydrogenases cysteine active site. gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0689 SCO0690 SCO0690 SCF15.11 SCF15.11 730984 731976 + oxidoreductase%2C molybdopterin binding subunit SCF15.11%2C possible oxidoreductase%2C molybdopterin binding subunit%2C len: 330 aa. Similar to many molybdopterin binding subunits of multipartite proteins including: Thauera aromatica TR:O33820 (EMBL:AJ001830) 4-hydroxybenzoyl-coA reductase Beta-subunit (324 aa)%2C fasta scores opt: 425 z-score: 493.1 E(): 4.3e-20 36.1%25 identity in 316 aa overlap and Pseudomonas putida TR:P72222 (EMBL:X98131) quinoline 2-oxidoreductase%2C QorM (288 aa)%2C fasta scores opt: 160 z-score: 190.3 E(): 0.0032 25.5%25 identity in 325 aa overlap. Contains a Pfam match to entry PF00941 dehydrog_molyb%2C Molybdopterin binding domain in dehydrogenase. gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0690 SCO0691 SCO0691 SCF15.12 SCF15.12 732005 734134 + oxidoreductase SCF42.01%2C possible oxidoreductase%2C partial CDS%2C len: > 369 aa. Similar to several including: Desulfovibrio gigas SW:MOP_DESGI (EMBL:X77222) aldehyde oxidoreductase (907 aa)%2C fasta scores opt: 255 z-score: 288.0 E(): 1.2e-08 28.4%25 identity in 388 aa overlap and Deinococcus radiodurans TR:AAF12400 (EMBL:AE001863) oxidoreductase (708 aa)%2C fasta scores opt: 1255 z-score: 1421.5 E():0 54.2%25 identity in 356 aa overlap. Overlaps and extends into CDS SCF15.12 on the adjoining cosmid SCF15. Contains a Pfam match to entry PF01315 Ald_Xan_dh_C%2C Aldehyde oxidase and xanthine dehydrogenase%2C C terminus.~SCF15.12%2C possible oxidoreductase%2C large subunit%2C partial CDS%2C len: > 374 aa. Similar to the C-terminal domain of many eukaryotic xanthine dehydrogenases including: Mus musculus (Mouse) SW:XDH_MOUSE (EMBL:X75129) xanthine dehydrogenase/oxidase (1335 aa)%2C fasta scores opt: 424 z-score: 459.8 E(): 3.1e-18 26.6%25 identity in 380 aa overlap and Homo sapiens (Human) SW:XDH_HUMAN (EMBL:D11456) xanthine dehydrogenase/oxidase (1332 aa)%2C fasta scores opt: 396 z-score: 429.4 E(): 1.5e-16 25.7%25 identity in 378 aa overlap. Also similar to Rhodobacter capsulatus (Rhodopseudomonas capsulata) TR:O54051(EMBL:AJ001013) xanthine dehydrogenase (EC 1.1.1.204) (779 aa)%2C fasta scores opt: 452 z-score: 493.7 E(): 4e-20 30.1%25 identity in 375 aa overlap. Contains a Pfam match to entry PF01315 Ald_Xan_dh_C%2C Aldehyde oxidase and xanthine dehydrogenase. gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0691 SCO0692 SCO0692 SCF42.02c. SCF42.02c. 734210 735667 - hypothetical protein SCF42.02c%2C possible membrane protein%2C len: 485 aa. Rich in the amino acid Ala. Contains possible membrane spanning hydrophobic domains. gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0692 SCO0693 SCO0693 SCF42.03 SCF42.03 735845 736192 + hypothetical protein SCF42.03%2C possible membrane protein%2C len: 115 aa. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain. Rich in Ala and Leu. gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0693 SCO0694 SCO0694 SCF42.04 SCF42.04 736312 736503 + hypothetical protein SCF42.04%2C unknown%2C len: 62 aa. gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0694 SCO0695 SCO0695 SCF42.05 SCF42.05 736520 737506 + hypothetical protein SCF42.05%2C unknown%2C len: 328 aa%3B similar to TR:Q9KZT0 (EMBL:AL353832) hypothetical protein SCE6.08 from Streptomyces coelicolor (326 aa) fasta scores%3B opt: 371%2C Z-score: 407.1%2C E(): 4.8e-15%2C 35.629%25 identity (39.145%25 ungapped) in 334 aa overlap. gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0695 SCO0696 SCO0696 SCF42.06c SCF42.06c 737846 738340 - hypothetical protein SCF42.06c%2C possible integral membrane protein%2C len: 164 aa. Contains multiple possible membrane spanning hydrophobic domains. gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0696 SCO0697 SCO0697 SCF42.07 SCF42.07 738595 739482 + gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0697 SCO0698 SCO0698 SCF42.08c SCF42.08c 739510 739875 - hypothetical protein SCF42.08c%2C unknown%2C len: 121 aa. gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0698 SCO0699 SCO0699 SCF42.09c SCF42.09c 739938 740231 - hypothetical protein SCF42.09c%2C unknown%2C len: 97 aa. gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0699 SCO0700 SCO0700 SCF42.10c SCF42.10c 740314 742083 - ABC transporter ATP-binding protein SCF42.10c%2C probable ABC transporter%2C ATP-binding component%2C len: 589 aa. The N-terminus is identical to the previously sequenced Streptomyces coelicolor TR:Q53899(EMBL:X60316) pleiotropic regulatory locus AbaA%2C OrfC (fragment)(>131 aa)%2C fasta scores opt: 856 z-score: 951.7 E(): 0 100.0%25 identity in 131 aa overlap. Also highly similar to many including: Escherichia coli SW:MSBA_ECOLI(EMBL:Z11796) probable transport ATP-binding protein%2C MsbA (582 aa)%2C fasta scores opt: 875 z-score: 963.0 E():0 31.4%25 identity in 566 aa overlap and Deinococcus radiodurans TR:AAF12435(EMBL:AE001863) ABC transporter%2C ATP-binding protein (602 aa)%2C fasta scores opt: 941 z-score: 1035.3 E():0 34.4%25 identity in 593 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and Pfam matches to entries PF00005 ABC_tran%2C ABC transporter and PF00664 ABC_membrane%2C ABC transporter transmembrane region. Also contains Prosite hits to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0700 SCO0701 SCO0701 SCF42.11c SCF42.11c 742242 742685 - hypothetical protein SCF42.11c%2C unknown%2C len: 147 aa. Identical to the previously published Streptomyces coelicolor TR:Q53898(EMBL:X60316) pleiotropic regulatory locus AbaA%2C OrfB (147 aa)%2C fasta scores opt: 958 z-score: 1195.2 E(): 0 99.3%25 identity in 147 aa overlap. gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0701 SCO0702 SCO0702 SCF42.12c SCF42.12c 742816 743394 - regulator SCF42.12c%2C possible regulator%2C len: 192 aa. Identical to the previously published Streptomyces coelicolor TR:Q53897 (EMBL:X60316) pleiotropic regulatory locus AbaA%2C OrfA (192 aa)%2C fasta scores opt: 1308 z-score: 1344.1 E():0 99.5%25 identity in 192 aa overlap. Also similar to Streptomyces coelicolor TR:Q9X8K2 (EMBL:AL049841) regulator SCE9.30 (154 aa)%2C fasta scores opt: 278 z-score: 299.0 E(): 2.9e-09 39.9%25 identity in 148 aa overlap. gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0702 SCO0703 SCO0703 SCF42.13 SCF42.13 743575 743802 + regulator SCF42.13%2C possible regulator%2C len: 75 aa. Identical to the previously published Streptomyces coelicolor TR:Q53896 (EMBL:X60316) pleiotropic antibiotic regulatory locus AbaA%2C OrfD (75 aa)%2C fasta scores opt: 507 z-score: 699.1 E(): 1.5e-31 98.7%25 identity in 75 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X8K3 (EMBL:AL049841) regulator SCE9.31c (83 aa)%2C fasta scores opt: 308 z-score: 431.8 E(): 1.2e-16 63.6%25 identity in 77 aa overlap. gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0703 SCO0704 SCO0704 SCF42.14 SCF42.14 743929 744847 + gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0704 SCO0705 SCO0705 SCF42.15c SCF42.15c 744945 745763 - hypothetical protein SCF42.15c%2C unknown%2C len: 272 aa. Similar to several proteins of undefined function from Streptomyces coelicolor TR:O86540(EMBL:AL031350) SC1F2.03C (300 aa)%2C fasta scores opt: 639 z-score: 770.1 E():0 41.4%25 identity in 261 aa overlap and TR:CAB59702(EMBL:AL132707) probable mannanase SCF51.04C (272 aa)%2C fasta scores opt: 744 z-score: 896.2 E():0 49.6%25 identity in 248 aa overlap gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0705 SCO0706 SCO0706 SCF42.16c SCF42.16c 745911 747194 - lipoprotein SCF42.16c%2C possible lipoprotein%2C len: 427 aa%2C Weakly similar to Pseudomonas aeruginosa SW:BRAC_PSEAE(EMBL:M31071) leucine-%2C isoleucine-%2C valine-%2C threonine-%2C and alanine-binding protein precursor (373 aa)%2C fasta scores opt: 239 z-score: 250.6 E(): 1.4e-06 24.0%25 identity in 341 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0706 SCO0707 SCO0707 SCF42.17c SCF42.17c 747191 748387 - branched-chain amino acid ABC transporter permease SCF42.17c%2C possible branched-chain amino acid ABC transport permease%2C len: 398 aa. Similar to many amino acid transporters including: Pseudomonas aeruginosa SW:BRAE_PSEAE (EMBL:D90223) high-affinity branched-chain amino acid transport protein BraE (417 aa)%2C fasta scores opt: 327 z-score: 334.2 E(): 3.2e-11 28.3%25 identity in 336 aa overlap and Streptomyces coelicolor TR:CAB52066 (EMBL:AL109732) branched-chain amino acid ABC transporter permease SC7H2.24 (608 aa)%2C fasta scores opt: 403 z-score: 407.6 E(): 2.6e-15 31.0%25 identity in 342 aa overlap. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0707 SCO0708 SCO0708 SCF42.18c SCF42.18c 748380 749279 - branched-chain amino acid ABC transporter SCF42.18c%2C possible branched-chain amino acid ABC transporter%2C len: 299 aa. Similar to many other transport proteins including: Pseudomonas aeruginosa SW:BRAD_PSEAE(EMBL:D90223) high-affinity branched-chain amino acid transport protein%2C BraD (307 aa)%2C fasta scores opt: 318 z-score: 364.2 E(): 6.8e-13 28.5%25 identity in 312 aa overlap and Deinococcus radiodurans TR:AAF09863(EMBL:AE001889) branched-chain amino acid ABC transporter%2C permease (285 aa)%2C fasta scores opt: 432 z-score: 492.1 E(): 5.1e-20 34.6%25 identity in 295 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0708 SCO0709 SCO0709 SCF42.19c SCF42.19c 749276 750076 - ABC transporter ATP-binding protein SCF42.19c%2C possible branched-chain amino acid transport ATP-binding protein%2C len: 266 aa. Similar to many including: Pseudomonas aeruginosa SW:BRAF_PSEAE(EMBL:D90223) high-affinity branched-chain amino acid transport ATP-binding protein%2C BraF (255 aa)%2C fasta scores opt: 689 z-score: 786.7 E():0 41.3%25 identity in 252 aa overlap and Deinococcus radiodurans TR:AAF11669(EMBL:AE002047) branched-chain amino acid ABC transporter%2C ATP-binding protein (259 aa)%2C fasta scores opt: 749 z-score: 854.2 E():0 46.9%25 identity in 256 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52067(EMBL:AL109732) branched-chain amino acid transport ATP-binding protein%2C SC7H2.25 (309 aa)%2C fasta scores opt: 638 z-score: 728.0 E():0 42.4%25 identity in 269 aa overlap and to the adjoining CDS on this cosmid%2C SCF42.20c (263 aa)%2C fasta scores opt: 364 z-score: 308.0 E(): 9.7e-12 35.8%25 identity in 271 aa overlap. Contains Prosite hits to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0709 SCO0710 SCO0710 SCF42.20c SCF42.20c 750073 750864 - ABC transporter ATP-binding protein SCF42.20c%2C possible branched-chain amino acid transport ATP-binding protein%2C len: 263 aa. Similar to many including: Pseudomonas aeruginosa SW:BRAG_PSEAE(EMBL:D90223) high-affinity branched-chain amino acid transport ATP-binding protein%2C BraG (233 aa)%2C fasta scores opt: 642 z-score: 685.0 E(): 9.1e-31 46.7%25 identity in 240 aa overlap and Streptomyces coelicolor TR:CAB52068(EMBL:AL109732) branched-chain amino acid transport ATP-binding protein%2C SC7H2.26 (238 aa)%2C fasta scores opt: 724 z-score: 770.7 E():0 48.5%25 identity in 241 aa overlap. Also similar to the adjoining CDS on this cosmid%2C SCF42.19c (263 aa)%2C fasta scores opt: 364 z-score: 308.0 E(): 9.7e-12 35.8%25 identity in 271 aa overlap. Contains Prosite hits to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0710 SCO0711 SCO0711 SCF42.21c SCF42.21c 751917 753197 - hypothetical protein SCF42.21c%2C hypothetical protein%2C len: 426 aa. The N-terminal 234 aa are identical to the previously published Streptomyces coelicolor TR:Q9ZIW4(EMBL:AF009336) hypothetical protein Orf4 (310 aa)%2C fasta scores opt: 1581 z-score: 1692.1 E():0 79.6%25 identity in 323 aa overlap. Sequence anomalies with the previously published sequence occur after codon 234. This CDS is also highly similar to Streptomyces sp. TR:O05479(EMBL:M86351) hypothetical protein encoded downstream of lipA and lipR (481 aa)%2C fasta scores opt: 923 z-score: 988.2 E(): 0 50.6%25 identity in 413 aa overlap. gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0711 SCO0712 SCO0712 lipR lipR 753318 756143 - transcriptional activator SCF42.22c%2C lipR%2C transcriptional activator%2C len: 941 aa. Identical to the previously sequenced and characterised: Streptomyces coelicolor TR:Q9ZIW5 (EMBL:AF009336) transcriptional activator of lipA%2C LipR (941 aa). Contains a Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and a helix-turn-helix motif situated between residues 864..885 (+4.08 SD). gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0712 SCO0713 SCO0713 lipA lipA 756314 757246 - lipase SCF42.23c%2C lipA%2C lipase (hypothetical protein)%2C len: 310 aa. Identical to the previously sequenced and characterised: Streptomyces coelicolor TR:Q9ZIW6(EMBL:AF009336) lipase%2C LipA (310 aa). Contains a Prosite hit to PS00120 Lipases%2C serine active site and a possible hydrophobic domain close to the N-terminus gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0713 SCO0714 SCO0714 SCF42.24 SCF42.24 757637 758524 + oxidoreductase SCF42.24%2C possible oxidoreductase%2C len: 295 aa. Identical to the previously sequenced Streptomyces coelicolor TR:Q9ZIW7 (EMBL:AF009336) Orf1 (fragment) (>195 aa). Also weakly similar to Sinorhizobium meliloti TR:O68965 (EMBL:AF059313) myo-inositol dehydrogenase (EC 1.1.1.18) (330 aa)%2C fasta scores opt: 242 z-score: 275.5 E(): 5.9e-08 26.5%25 identity in 302 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0714 SCO0715 SCO0715 SCF42.25c SCF42.25c 758531 758902 - hypothetical protein SCF42.25c%2C unknown%2C len: 123 aa. gene gene701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0715 SCO0716 SCO0716 SCF42.26 SCF42.26 759197 760399 + glycosyl hydrolase SCF42.26%2C possible glycosyl hydrolase (hypothetical protein)%2C len: 400 aa. Similar to several including: Arthrobacter sp. (strain YCWD3) SW:E13B_ARTSP(EMBL:D23668) glucan endo-1%2C3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa)%2C fasta scores opt: 425 z-score: 452.8 E(): 7.8e-18 34.5%25 identity in 414 aa overlap and Streptomyces matensis TR:Q9Z4I2(EMBL:AB019428) laminaripentaose-producing beta-1%2C3-guluase (lphase) precursor (401 aa)%2C fasta scores opt: 477 z-score: 509.6 E(): 5.4e-21 38.7%25 identity in 413 aa overlap. Contains a possible N-terminal signal sequence gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0716 SCO0717 SCO0717 SCF42.27 SCF42.27 760471 761598 + hypothetical protein SCF42.27%2C possible integral membrane protein%2C len: 375 aa. Similar to several other membrane proteins from Streptomyces coelicolor e.g. TR:CAB56388(EMBL:AL118515) SCD17.11 (454 aa)%2C fasta scores opt: 569 z-score: 648.9 E(): 9.3e-29 36.4%25 identity in 360 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0717 SCO0718 SCO0718 SCF42.28 SCF42.28 761675 761896 + hypothetical protein SCF42.28%2C unknown%2C len: 73 aa. gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0718 SCO0719 SCO0719 SCF42.29c SCF42.29c 762009 762485 - hypothetical protein SCF42.29c%2C hypothetical protein%2C len: 158 aa%3B similar to TR:Q9KZJ6 (EMBL:AL353863) Streptomyces coelicolor hypothetical protein SCG8A.03%2C 156 aa%3B fasta scores: opt: 570 Z-score: 608.7 E(): 2.8e-26%3B 59.477%25 identity in 153 aa overlap gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0719 SCO0720 SCO0720 SCF42.30c SCF42.30c 762558 764051 - hypothetical protein SCF42.30c%2C possible integral membrane protein%2C len: 497 aa. Weakly similar to several proteins of unknown function e.g. Mycobacterium tuberculosis SW:YT19_MYCTU(EMBL:Z79700) (455 aa)%2C fasta scores opt: 157 z-score: 177.3 E(): 0.017 27.1%25 identity in 450 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0720 SCO0721 SCO0721 SCF42.31c. SCF42.31c. 764216 766594 - glycosyl transferase SCF42.31c%2C possible glycosyl transferase%2C len: 792 aa. Similar to Lactobacillus sanfrancisco TR:O87772 (EMBL:AJ224340) maltosephosphorylase (EC 2.4.1.8) MapA (753 aa)%2C fasta scores opt: 1045 z-score: 1168.4 E():0 29.5%25 identity in 766 aa overlap. Also highly similar to a number of proteins of undefined function e.g. Mycobacterium tuberculosis SW:YY01_MYCTU(EMBL:Z77165) (786 aa)%2C fasta scores opt: 3054 z-score: 3419.0 E():0 59.1%25 identity in 785 aa overlap gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0721 SCO0722 SCO0722 SCF42.32 SCF42.32 766591 767331 - hydrolase SCF42.32%2C possible hydrolase%2C len: 246 aa. Similar to several proteins of undefined function including: Mycobacterium tuberculosis SW:Y09T_MYCTU (EMBL:Z77165) (262 aa)%2C fasta scores opt: 888 z-score: 1047.3 E():0 56.3%25 identity in 245 aa overlap and Mycobacterium leprae SW:YY00_MYCLE (EMBL:U00015) (261 aa) fasta scores opt: 843 z-score: 994.7 E():0 51.6%25 identity in 248 aa overlap. Contains a Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase. gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0722 SCO0723 SCO0723 frcK frcK 767385 768074 + fructose transport system kinase 3SC5B7.01%2C conserved hypothetical protein (fragment)%2C len: >151 aa%3B similar to TR:Q9SA67 (EMBL:AC006550) Arabidopsis thaliana F10O3 protein%2C 270 aa%3B fasta scores: opt: 219 z-score: 240.7 E(): 7.1e-06%3B 30.4%25 identity in 125 aa overlap~SCF42.33%2C unknown%2C partial CDS%2C len: > 117 aa. Similar to a protein of undefined function from Schizosaccharomyces pombe (Fission yeast) TR:CAB61463(EMBL:AL133156) (235 aa)%2C fasta scores opt: 241 z-score: 282.8 E(): 2.3e-08 37.0%25 identity in 119 aa overlap and Escherichia coli SW:YGGC_ECOLI(EMBL:X14436) (237 aa)%2C fasta scores opt: 184 z-score: 219.2 E(): 8.1e-05 36.4%25 identity in 99 aa overlap. Contains a Prosite Hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0723 SCO0724 SCO0724 3SC5B7.02 3SC5B7.02 768426 769367 + transcriptional regulator 3SC5B7.02%2C probable transcriptional regulator%2C len: 313 aa%3B similar to TR:Q9KZ73 (EMBL:AL354048) Streptomyces coelicolor transcriptional regulator SCE25.16c%2C 289 aa%3B fasta scores: opt: 721 z-score: 810.2 E(): 0%3B 43.9%25 identity in 289 aa overlap and to SW:HEXR_PSEAE (EMBL:AF029673) Pseudomonas aeruginosa hex regulon repressor HexR%2C 285 aa%3B fasta scores: opt: 167 z-score: 194.4 E(): 0.0027%3B 26.8%25 identity in 224 aa overlap. Contains a possible coiled-coil region at approx. residues 125..147 and a possible helix-turn-helix motif at residues 69..90 (+5.16 SD) gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0724 SCO0725 SCO0725 3SC5B7.03 3SC5B7.03 769688 770065 + hypothetical protein 3SC5B7.03%2C unknown%2C len: 125 aa gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0725 SCO0726 SCO0726 3SC5B7.04c 3SC5B7.04c 770144 770632 - oxidoreductase 3SC5B7.04c%2C possible oxidoreductase%2C len: 162 aa%3B similar to TR:Q9K416 (EMBL:AL359779) Streptomyces coelicolor flavin-dependent reductase SCG22.29c%2C 169 aa%3B fasta scores: opt: 184 z-score: 248.1 E(): 2.7e-06%3B 34.1%25 identity in 132 aa overlap. Contains Pfam match to entry PF01613 Flavin_Reduct%2C Flavin reductase like domain gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0726 SCO0727 SCO0727 3SC5B7.05c 3SC5B7.05c 770665 771588 - hypothetical protein 3SC5B7.05c%2C unknown%2C len: 307 aa gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0727 SCO0728 SCO0728 3SC5B7.06 3SC5B7.06 771628 772362 + regulatory protein 3SC5B7.06%2C probable regulatory protein%2C len: 244 aa%3B similar to TR:Q9XDF0 (EMBL:AF074603) Streptomyces griseus transcriptional repressor NonG%2C 242 aa%3B fasta scores: opt: 885 z-score: 1073.4 E(): 0%3B 64.1%25 identity in 237 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and match to Prosite entry PS01081 Bacterial regulatory proteins%2C tetR family signature gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0728 SCO0729 SCO0729 3SC5B7.07 3SC5B7.07 772544 772966 + hypothetical protein 3SC5B7.07%2C conserved hypothetical protein%2C len: 140 aa%3B similar to TR:O27449 (EMBL:AE000902) Methanobacterium thermoautotrophicum conserved protein MTH1398%2C 133 aa%3B fasta scores: opt: 122 z-score: 167.4 E(): 0.085%3B 26.7%25 identity in 116 aa overlap gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0729 SCO0730 SCO0730 3SC5B7.08c 3SC5B7.08c 772974 773435 - hypothetical protein 3SC5B7.08c%2C conserved hypothetical protein%2C len: 153 aa%3B similar to TR:O86340 (EMBL:Z97984) Mycobacterium tuberculosis hypothetical 14.8 kDa protein MTV019.02c%2C 134 aa%3B fasta scores: opt: 309 z-score: 388.9 E(): 3.9e-14%3B 39.0%25 identity in 123 aa overlap gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0730 SCO0731 SCO0731 3SC5B7.09c 3SC5B7.09c 773432 774613 - transferase 3SC5B7.09c%2C probable transferase%2C len: 444 aa%3B similar to SW:MALY_ECOLI (EMBL:M60722) Escherichia coli aminotransferase MalY protein%2C 390 aa%3B fasta scores: opt: 522 z-score: 589.7 E(): 2.5e-25%3B 30.8%25 identity in 370 aa overlap gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0731 SCO0732 SCO0732 3SC5B7.10 3SC5B7.10 774765 776129 + protease 3SC5B7.10%2C probable protease%2C len: 454 aa%3B similar to SW:PRTD_STRGR (EMBL:L29019) Streptomyces griseus serine protease D precursor (EC 3.4.21.-) SprD%2C 392 aa%3B fasta scores: opt: 964 z-score: 909.8 E(): 0%3B 45.4%25 identity in 366 aa overlap. Contains Pfam match to entry PF00089 trypsin%2C Trypsin and match to Prosite entry PS00134 Serine proteases%2C trypsin family%2C histidine active site and PS00135 Serine proteases%2C trypsin family%2C serine active site. Also contains possible N-terminal region signal peptide sequence gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0732 SCO0733 SCO0733 3SC5B7.11c 3SC5B7.11c 776203 776388 - hypothetical protein 3SC5B7.11c%2C hypothetical protein%2C len: 61 aa%3B similar to TR:Q9K3Z9 (EMBL:AL359949) Streptomyces coelicolor hypothetical 6.5 kDa protein 2SCG61.16%2C 59 aa%3B fasta scores: opt: 196 z-score: 304.8 E(): 1.9e-09%3B 59.3%25 identity in 54 aa overlap gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0733 SCO0734 SCO0734 3SC5B7.12c 3SC5B7.12c 776554 777828 - transcriptional repressor 3SC5B7.12c%2C probable transcriptional repressor%2C len: 424 aa%3B similar to SW:MLC_ECOLI (EMBL:D32222) Escherichia coli transcriptional regulator Mlc protein%2C 406 aa%3B fasta scores: opt: 387 z-score: 414.7 E(): 1.4e-15%3B 24.1%25 identity in 344 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and possible helix-turn-helix motif at residues 64..85 (+6.19 SD) gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0734 SCO0735 SCO0735 3SC5B7.13 3SC5B7.13 777895 779097 + oxidoreductase 3SC5B7.13%2C possible oxidoreductase%2C len: 400 aa%3B low similarity to TR:Q9KDG5 (EMBL:AP001511) Bacillus halodurans NADH-dependent dehydrogenase BH1248%2C 340 aa%3B fasta scores: opt: 243 z-score: 286.8 E(): 1.9e-08%3B 24.8%25 identity in 242 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0735 SCO0736 SCO0736 3SC5B7.14c 3SC5B7.14c 779131 779826 - hypothetical protein 3SC5B7.14c%2C possible hypothetical protein%2C len: 231 aa. Contains possible N-terminal region cleavable signal peptide sequence gene gene722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0736 SCO0737 SCO0737 3SC5B7.15c 3SC5B7.15c 780012 780812 - oxidoreductase gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0737 SCO0738 SCO0738 3SC5B7.16 3SC5B7.16 780863 781402 + hypothetical protein 3SC5B7.16%2C possible hypothetical protein%2C len: 179 aa. Contains possible N-terminal region signal peptide sequence gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0738 SCO0739 SCO0739 3SC5B7.17c 3SC5B7.17c 781386 782312 - short chain dehydrogenase 3SC5B7.17c%2C possible oxidoreductase%2C len: 308 aa%3B highly similar to TR:O54118 (EMBL:AL021529) Streptomyces coelicolor oxidoreductase SC10A5.27c%2C 326 aa%3B fasta scores: opt: 1123 z-score: 1316.4 E(): 0%3B 60.1%25 identity in 308 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0739 SCO0740 SCO0740 3SC5B7.18c 3SC5B7.18c 782467 783096 - hydrolase 3SC5B7.18c%2C probable hydrolase%2C len: 209 aa%3B identical to previously sequenced TR:Q9ZNB2 (EMBL:AB019513) Streptomyces coelicolor similar to Mycobacterium Tuberculosis hypothetical protein RV2260%2C 209 aa and similar to SW:GL2M_ARATH (EMBL:U90928) Arabidopsis thaliana hydroxyacylglutathione hydrolase%2C mitochondrial precursor (EC 3.1.2.6) Glx2-1%2C 331 aa%3B fasta scores: opt: 230 z-score: 271.1 E(): 1.4e-07%3B 30.1%25 identity in 173 aa overlap. Contains Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0740 SCO0741 SCO0741 3SC5B7.19c 3SC5B7.19c 783096 784184 - oxidoreductase 3SC5B7.19c%2C probable oxidoreductase%2C len: 362 aa%3B highly similar to SW:FADH_AMYME Amycolatopsis methanolica NAD/mycothiol-dependent formaldehyde dehydrogenase (EC 1.2.1.-) FadH%2C 360 aa%3B fasta scores: opt: 1833 z-score: 1972.8 E(): 0%3B 74.4%25 identity in 359 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and matches to Prosite entries PS00190 Cytochrome c family heme-binding site signature%2C PS00059 Zinc-containing alcohol dehydrogenases signature and PS00435 Peroxidases proximal heme-ligand signature gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0741 SCO0742 SCO0742 3SC5B7.20 3SC5B7.20 784362 786116 + ABC transporter SCF81.01%2C ABC transporter (partial CDS)%2C len: >38 aa%3B identical to C-terminal region of previously sequenced TR:Q9ZNB0 (EMBL:AB019513) Streptomyces coelicolor ABC transporter%2C 584 aa~3SC5B7.20%2C ABC transporter ATP-binding protein (fragment)%2C len: >578 aa%3B identical to previously sequenced TR:Q9ZNB0 (EMBL:AB019513) Streptomyces coelicolor ABC transporter%2C 584 aa. Contains Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains possible hydrophobic membrane spanning regions gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0742 SCO0743 SCO0743 SCF81.02c SCF81.02c 786125 786409 - hypothetical protein SCF81.02c%2C hypothetical protein%2C len: 94 aa. Contains possible N-terminal region signal peptide sequence gene gene729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0743 SCO0744 SCO0744 SCF81.03 SCF81.03 786591 786956 + hypothetical protein SCF81.03%2C unknown%2C len: 121 aa%3B similar to TR:Q98BX4 (EMBL:AP003006) MLL5389 protein from Rhizobium loti (Mesorhizobium loti) (124 aa) fasta scores%3B opt: 363%2C Z-score: 452.3%2C E(): 1.5e-17%2C 43.750%25 identity (43.750%25 ungapped) in 112 aa overlap. gene gene730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0744 SCO0745 SCO0745 SCF81.04c SCF81.04c 786984 787643 - TetR family transcriptional regulator SCF81.04c%2C possible tetR-family transcriptional regulator%2C len: 219 aa%3B similar to various Streptomyces transcriptional regulators%2C e.g. TR:Q9ZBK0 (EMBL:AL035161) Streptomyces coelicolor transcriptional regulator SC9C7.10c%2C 272 aa%3B fasta scores: opt: 189 z-score: 243.3 E(): 3.5e-06%3B 29.8%25 identity in 218 aa overlap. Contains match to Pfam entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0745 SCO0746 SCO0746 SCF81.05 SCF81.05 787843 789096 + Ser/Thr protein kinase SCF81.05%2C possible Ser/Thr protein kinase (hypothetical protein)%2C len: 462 aa%3B low similarity to C-terminus SW:PKWA_THECU (EMBL:U23820) Thermomonospora curvata Ser/Thr protein kinase PkwA (EC 2.7.1.-)%2C 742 aa%3B fasta scores: opt: 157 z-score: 167.3 E(): 0.06%3B 23.6%25 identity in 309 aa overlap. Contains possible N-terminal signal peptide sequence gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0746 SCO0747 SCO0747 SCF81.06c SCF81.06c 789337 789837 - hypothetical protein SCF81.06c%2C hypothetical protein%2C len: 166 aa%3B similar to various hypothetical proteins%2C e.g. TR:AAD36153 (EMBL:AE001768) Thermotoga maritima conserved hypothetical protein TM1076%2C 157 aa%3B fasta scores: opt: 293 z-score: 385.9 E(): 4e-14%3B 39.1%25 identity in 133 aa overlap and to TR:Q9CCZ0 (EMBL:AL583926) Mycobacterium leprae conserved hypothetical protein ML 2654%2C 165 aa%3B fasta scores: opt: 642 Z-score: 785.7 E(): 4e-36%3B 60.248%25 identity in 161 aa overlap gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0747 SCO0748 SCO0748 SCF81.07 SCF81.07 789960 790541 + hydrolase SCF81.07%2C possible hydrolase%2C len: 193 aa%3B similar to TR:P94573 (EMBL:Z82987) Bacillus subtilis hypothetical 21.1KD protein%2C 189 aa%3B fasta scores: opt: 504 z-score: 582.8 E(): 4.4e-25%3B 48.4%25 identity in 190 aa overlap and to SW:ENTB_ECOLI (EMBL:M24148) Escherichia coli isochorismatase (EC 3.3.2.1) (2%2C3 dihydro-2%2C3 dihydroxybenzoate synthase) EntB%2C 285 aa%3B fasta scores: opt: 205 z-score: 242.1 E(): 4.1e-06%3B 26.8%25 identity in 183 aa overlap. Contains match to Pfam entry PF00857 Isochorismatase%2C Isochorismatase family gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0748 SCO0749 SCO0749 SCF81.08c SCF81.08c 790561 791535 - dehydratase SCF81.08c%2C probable dehydratase%2C len: 324 aa%3B higly similar to TR:AAD55454 (EMBL:AF055579) Streptomyces antibioticus dehydratase OleE%2C 335 aa%3B fasta scores: opt: 1571 z-score: 1848.7 E(): 0%3B 74.0%25 identity in 323 aa overlap and to SW:STRE_STRGR (EMBL:X62567) Streptomyces griseus DTDP-glucose 4%2C6-dehydratase (EC 4.2.1.46) StrE%2C 328 aa%3B fasta scores: opt: 1422 z-score: 1674.0 E(): 0%3B 68.6%25 identity in 318 aa overlap. Contains match to Pfam entry PF01370 Epimerase%2C NAD dependent epimerase/dehydratase family and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0749 SCO0750 SCO0750 SCF81.09c SCF81.09c 791701 791880 - hypothetical protein SCF81.09c%2C unknown%2C len: 59 aa gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0750 SCO0751 SCO0751 SCF81.10c SCF81.10c 791981 794467 - regulatory protein SCF81.10c%2C possible regulatory protein%2C len: 894 aa%3B similar to TR:Q9ZBJ0 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.20%2C 860 aa%3B fasta scores: opt: 663 z-score: 716.6 E(): 1.5e-32%3B 29.6%25 identity in 873 aa overlap and to TR:CAB44394 (EMBL:AL078610) Streptomyces coelicolor regulatory protein SCH35.33c%2C 422 aa%3B fasta scores: opt: 305 z-score: 312.4 E(): 5e-10%3B 33.3%25 identity in 258 aa overlap. Contains match to Pfam entry PF01590 GAF%2C GAF domain gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0751 SCO0752 SCO0752 salO salO 794689 796002 - protease SCF81.11c%2C salO%2C protease precursor%2C len: 437 aa%3B highly similar to but longer than TR:Q54395 (EMBL:D50081) Streptomyces lividans%2C SalO precursor%2C 354 aa%3B fasta scores: opt: 1713 z-score: 1480.6 E(): 0%3B 89.1%25 identity in 367 aa overlap%2C to SW:PRTD_STRGR (EMBL:L29019) Streptomyces griseus serine protease D precursor (EC 3.4.21.-) SgpD%2C 392 aa%3B fasta scores: opt: 1097 z-score: 952.8 E(): 0%3B 53.4%25 identity in 363 aa overlap and to Streptomyces coelicolor StI11.30c%2C 360 aa%3B fasta scores: opt: 1093 z-score: 833.4 E(): 0%3B 52.8%25 identity in 362 aa overlap. Contains match to Pfam entry PF00089 trypsin%2C Trypsin and two matches to Prosite entry PS00134 Serine proteases%2C trypsin family%2C histidine active site. Contains also possible N-terminal signal sequence peptide and degenerate repeat x6 GGA(G/D)AG gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0752 SCO0753 SCO0753 SCF81.12 SCF81.12 796584 796799 + hypothetical protein SCF81.12%2C unknown%2C len: 71 aa gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0753 SCO0754 SCO0754 SCF81.13 SCF81.13 796977 797723 + hypothetical protein SCF81.13%2C hypothetical protein%2C len: 268 aa. Contains possible N-teminal signal sequence peptide gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0754 SCO0755 SCO0755 SCF81.14 SCF81.14 797720 799942 + ABC transporter SCF81.14%2C possible ABC transporter%2C len: 740 aa%3B similar to SW: COMA_STRPN (EMBL:M36180) Streptococcus pneumoniae transport ATP-binding protein ComA%2C 717 aa%3B fasta scores: opt: 1035 z-score: 1141.5 E(): 0%3B 29.1%25 identity in 721 aa overlap. Contains two matches to Pfam entries PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and two to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0755 SCO0756 SCO0756 SCF81.15 SCF81.15 799944 802766 + ABC transporter SCF81.15%2C possible ABC transporter%2C len: 940 aa%3B similar to TR:P74829 (EMBL:U51197) Sphingomonas sp. S88 hypothetical 79.4 KD protein AtrB%2C 728 aa%3B fasta scores: opt: 803 z-score: 870.4 E(): 0%3B 32.7%25 identity in 562 aa overlap and to SW:CYAB_BORPE (EMBL:X14199) Bordetella pertussis cyclolysin secretion ATP-binding protein CyaB%2C 712 aa%3B fasta scores: opt: 785 z-score: 851.0 E(): 0%3B 32.2%25 identity in 631 aa overlap. Contains two matches to Pfam entries PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and two to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0756 SCO0757 SCO0757 SCF81.16 SCF81.16 802797 803807 + phosphatase SCF81.16%2C possible phosphatase%2C len: 336 aa%3B low similarity to SW:PPX_ECOLI (EMBL:L06129) Escherichia coli exopolyphosphatase (EC 3.6.1.11) (metaphosphatase) Ppx%2C 512 aa%3B fasta scores: opt: 251 z-score: 287.5 E(): 1.2e-08%3B 24.8%25 identity in 303 aa overlap gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0757 SCO0758 SCO0758 SCF81.17 SCF81.17 803856 804035 + hypothetical protein SCF81.17%2C unknown%2C len: 59 aa gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0758 SCO0759 SCO0759 SCF81.18 SCF81.18 804091 805122 + hypothetical protein SCF81.18%2C unknown%2C len: 343 aa gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0759 SCO0760 SCO0760 SCF81.19 SCF81.19 805135 805797 + methyltransferase SCF81.19%2C probable methyltransferase%2C len: 220 aa%3B similar to TR:O27384 (EMBL:AE000896) Methanobacterium thermoautotrophicum methyltransferase related protein MTH1329%2C 196 aa%3B fasta scores: opt: 454 z-score: 525.3 E(): 6.9e-22%3B 44.2%25 identity in 190 aa overlap and to TR:Q53742 (EMBL:X92429) Streptomyces lipmanii (Streptomyces alboniger) N-methyl-transferase Pur5%2C 228 aa%3B fasta scores: opt: 228 z-score: 268.6 E(): 1.4e-07%3B 33.3%25 identity in 192 aa overlap. Contains match to Prosite entry PS00092 N-6 Adenine-specific DNA methylases signature gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0760 SCO0761 SCO0761 SCF81.20 SCF81.20 805859 806038 + hypothetical protein SCF81.20%2C unknown%2C len: 59 aa gene gene747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0761 SCO0762 SCO0762 SCF81.21c SCF81.21c 806172 806606 - protease inhibitor protein subtilase-type%3B inhibits bacterial serine proteases gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0762 SCO0763 SCO0763 SCF81.22 SCF81.22 806966 808135 + oxidoreductase SCF81.22%2C probable oxidoreductase%2C len: 535 aa%3B similar to SW:LA2M_MYCSM (EMBL:J05402) Mycobacterium smegmatis lactate 2-monooxygenase (EC 1.13.12.4) (lactate oxidase) La2M%2C 393 aa%3B fasta scores: opt: 1102 z-score: 1235.6 E(): 0%3B 44.6%25 identity in 379 aa overlap. Contains match to Pfam entry PF01070 FMN_dh%2C FMN-dependent dehydrogenase and to Prosite entry PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site gene gene749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0763 SCO0764 SCO0764 SCF81.23c SCF81.23c 808206 809813 - hydrolase SCF81.23c%2C possible hydrolase%2C len: 536 aa%3B low similarity to SW:E13B_OERXA (EMBL:M60826) Oerskovia xanthineolytica glucan endo-1%2C3-beta-glucosidase precursor (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase) ((1->3)-beta-glucanase) 548 aa%3B fasta scores: opt: 190 z-score: 208.5 E(): 0.00031%3B 28.3%25 identity in 166 aa overlap gene gene750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0764 SCO0765 SCO0765 cel1 cel1 810172 812415 - endoglucanase SCF81.24c%2C cel1%2C endoglucanase%2C len: 747 aa%3B highly similar to SW:GUN1_STRRE (EMBL:X65616) Streptomyces reticulii cellulase 1 precursor (EC 3.2.1.4) (endoglucanase) (endo-1%2C4-beta-glucanase) (avicelase) Cel1%2C 746 aa%3B fasta scores: opt: 4213 z-score: 4621.9 E(): 0%3B 80.3%25 identity in 747 aa overlap. Contains two matches to Pfam entries PF00759 Glyco_hydro_9%2C Glycosyl hydrolase family 9 and to Prosite entry PS00698 Glycosyl hydrolases family 9 active sites signature 2. Also contains N-terminal region signal peptide sequence and a possible helix-turn-helix motif at residues 119..140 (+2.81 SD) gene gene751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0765 SCO0766 SCO0766 SCF81.25c SCF81.25c 812569 815655 - beta-galactosidase SCF81.25c%2C possible beta-galactosidase%2C len: 1028 aa%3B similar to SW:BGA2_ECOLI (EMBL:M64441) Escherichia coli evolved beta-galactosidase alpha-subunit (EC 3.2.1.23) (lactase) 1031 aa%3B fasta scores: opt: 482 z-score: 519.9 E(): 1.4e-21%3B 30.6%25 identity in 464 aa overlap. Contains N-terminal signal peptide sequence gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0766 SCO0767 SCO0767 SCF81.26 SCF81.26 815808 818315 + hypothetical protein SCF81.26%2C hypothetical protein%2C len: 835 aa%3B similar to various Streptomyces hypothetical proteins%2C e.g. TR:Q9ZBJ0 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.20%2C 860 aa%3B fasta scores: opt: 1329 z-score: 1414.8 E(): 0%3B 36.8%25 identity in 835 aa overlap. Contains match to Pfam entry PF01590 GAF%2C GAF domain and two matches to Pfam entry PF00989 PAS%2C PAS domain gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0767 SCO0768 SCO0768 SCF81.27 SCF81.27 818446 819111 + lipoprotein SCF81.27%2C possible lipoprotein%2C len: 221 aa. Contains N-terminal signal peptide sequence%2C and appropriately positioned Prosite entry PS00013 probable lipoprotein Prokaryotic membrane lipoprotein lipid attachment sit gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0768 SCO0769 SCO0769 3SCF60.01c 3SCF60.01c 819148 820116 - aldo/keto reductase 3SCF60.01c%2C probable oxidoreductase (fragment)%2C len: >53 aa%3B similar to SW:YAJO_ECOLI (EMBL:AE000148) Escherichia coli hypothetical oxidoreductase in pgpA-ispA intergenic region YajO%2C 324 aa%3B fasta scores: opt: 250 z-score: 383.7 E(): 7.6e-14%3B 65.4%25 identity in 52 aa overlap~SCF81.28c%2C probable aldo/keto reductase (partial CDS)%2C len: >307 aa%3B similar to TR:AAD30468 (EMBL:AF124928) Streptomyces clavuligerus aldo/keto reductase family 2 enzyme Cvm1%2C 344 aa%3B fasta scores: opt: 521 z-score: 608.2 E(): 1.7e-26%3B 35.3%25 identity in 323 aa overlap and to SW:NORA_ASPFL (EMBL:U32377) Aspergillus flavus Norsolorinic acid reductase (EC 1.1.1.-) NorA%2C 388 aa%3B fasta scores: opt: 562 z-score: 654.8 E(): 4.3e-29%3B 33.7%25 identity in 303 aa overlap. Contains match to Pfam entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0769 SCO0770 SCO0770 3SCF60.02c 3SCF60.02c 820194 820751 - hypothetical protein 3SCF60.02c%2C possible membrane protein%2C len: 185 aa. Contains possible hydrophobic membrane spanning region gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0770 SCO0771 SCO0771 3SCF60.03c 3SCF60.03c 820761 821198 - hypothetical protein 3SCF60.03c%2C conserved hypothetical protein%2C len: 145 aa%3B identical to TR:O85694 (EMBL:AF072709) Streptomyces lividans hypothetical 17.2 kDa protein%2C 145 aa gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0771 SCO0772 SCO0772 3SCF60.04 3SCF60.04 821295 821873 + regulatory protein 3SCF60.04%2C possible regulatory protein%2C len: 192 aa%3B identical to TR:O85695 (EMBL:AF072709) Streptomyces lividans transcriptional regulator%2C 192 aa. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0772 SCO0773 SCO0773 3SCF60.05c 3SCF60.05c 821848 822048 - ferredoxin 3SCF60.05c%2C soyB2%2C probable ferredoxin%2C len: 66 aa%3B identical to TR:O85696 (EMBL:AF072709) Streptomyces lividans ferredoxin%2C 66 aa and similar to SW:FERS_STRGR (EMBL:X63601) Streptomyces griseus ferredoxin SoyB%2C 65 aa%3B fasta scores: opt: 269 z-score: 369.1 E(): 5e-13%3B 61.9%25 identity in 63 aa overlap gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0773 SCO0774 SCO0774 3SCF60.06c 3SCF60.06c 822061 823299 - cytochrome P450 3SCF60.06c%2C probable cytochrome P450%2C len: 412 aa%3B almost identical to TR:O85697 (EMBL:AF072709) Streptomyces lividans cytochrome P450 oxidoreductase%2C 406 aa and highly similar to SW:CPXH_STRGR (EMBL:X63601) Streptomyces griseus cytochrome P450 SoyC%2C 412 aa%3B fasta scores: opt: 1894 z-score: 2107.2 E(): 0%3B 67.5%25 identity in 412 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 and match to Prosite entry PS00086 Cytochrome P450 cysteine heme-iron ligand signature gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0774 SCO0775 SCO0775 3SCF60.07 3SCF60.07 823609 824058 + hypothetical protein 3SCF60.07%2C conserved hypothetical protein%2C len: 149 aa%3B identical to TR:O85698 (EMBL:AF072709) Streptomyces lividans hypothetical 16.7 kDa protein%2C 149 aa and similar to SW:YF58_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis hypothetical 16.4 kDa protein MTCY48.07c%2C 148 aa%3B fasta scores: opt: 695 z-score: 894.5 E(): 0%3B 69.1%25 identity in 149 aa overlap gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0775 SCO0776 SCO0776 3SCF60.08c 3SCF60.08c 824123 825139 - hypothetical protein 3SCF60.08c%2C possible integral membrane protein%2C len: 338 aa%3B identical to TR:O85699 (EMBL:AF072709) Streptomyces lividans hypothetical 35.5 kDa protein%2C 338 aa. Contains Pfam match to entry PF01545 Cation_efflux%2C Cation efflux family. Also contains possible hydrophobic membrane spanning regions gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0776 SCO0777 SCO0777 3SCF60.09 3SCF60.09 825287 826312 + hypothetical protein 3SCF60.09%2C conserved hypothetical protein%2C len: 341 aa%3B identical to TR:O85700 (EMBL:AF072709) Streptomyces lividans hypothetical 38.1 kDa protein%2C 341 aa and similar to TR:AAG05998 (EMBL:AE004689) Pseudomonas aeruginosa conserved hypothetical protein PA2610%2C 324 aa%3B fasta scores: opt: 838 z-score: 962.6 E(): 0%3B 44.6%25 identity in 323 aa overlap. Contains Pfam match to entry PF00043 GST%2C Glutathione S-transferases gene gene763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0777 SCO0778 SCO0778 3SCF60.10 3SCF60.10 826361 826669 + hypothetical protein 3SCF60.10%2C possible integral membrane protein%2C len: 102 aa. Contains possible hydrophobic membrane spanning regions gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0778 SCO0779 SCO0779 3SCF60.11c 3SCF60.11c 826690 827085 - hypothetical protein 3SCF60.11c%2C conserved hypothetical protein%2C len: 131 aa%3B identical to TR:O85701 (EMBL:AF072709) Streptomyces lividans hypothetical 14.2 kDa protein%2C 131 aa and similar to TR:Q9L0J1 (EMBL:AL161691) Streptomyces coelicolor hypothetical 15.7 kDa protein SCD40A.20%2C 145 aa%3B fasta scores: opt: 179 z-score: 233.2 E(): 1.8e-05%3B 31.8%25 identity in 110 aa overlap gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0779 SCO0780 SCO0780 3SCF60.12 3SCF60.12 827277 828218 + zinc-binding oxidoreductase 3SCF60.12%2C probable zinc-binding oxidoreductase%2C len: 313 aa%3B identical to TR:O85702 (EMBL:AF072709) Streptomyces lividans oxidoreductase%2C 313 aa and similar to SW:QOR_HUMAN (EMBL:S58039) Homo sapiens quinone oxidoreductase (EC 1.6.5.5) CryZ%2C 329 aa%3B fasta scores: opt: 467 z-score: 501.6 E(): 2.1e-20%3B 32.5%25 identity in 329 aa overlap and to TR:CAB70647 (EMBL:AL137242) Streptomyces coelicolor zinc-binding oxidoreductase SC8F4.21%2C 339 aa%3B fasta scores: opt: 1311 z-score: 1209.2 E(): 0%3B 66.1%25 identity in 310 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0780 SCO0781 SCO0781 3SCF60.13 3SCF60.13 828289 828789 + anti sigma factor antagonist 3SCF60.13%2C possible anti sigma factor antagonist%2C len: 166 aa%3B C-terminal region identical to TR:O85703 (EMBL:AF072709) Streptomyces lividans hypothetical 14.3 kDa protein%2C 128 aa and similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist BldG%2C 113 aa%3B fasta scores: opt: 199 z-score: 266.9 E(): 2.4e-07%3B 31.5%25 identity in 108 aa overlap. Contains Pfam match to entry PF01740 STAS%2C STAS domain gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0781 SCO0782 SCO0782 3SCF60.14c 3SCF60.14c 828755 829708 - ribose-phosphate pyrophosphokinase 3SCF60.14c%2C prsA%2C ribose-phosphate pyrophosphokinase%2C len: 317 aa%3B similar to SW:KPRS_SYNP7 (EMBL:D14994) Synechococcus sp. ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PrsA%2C 331 aa%3B fasta scores: opt: 795 z-score: 931.4 E(): 0%3B 42.7%25 identity in 307 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran%2C Phosphoribosyl transferase domain gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0782 SCO0783 SCO0783 3SCF60.15 3SCF60.15 829910 831817 + tetracycline resistance protein 3SCF60.15%2C tetM%2C tetracycline resistance protein%2C len: 635 aa%3B identical to SW:TETM_STRLI (EMBL:M74049) Streptomyces lividans tetracycline resistance protein TetM%2C 639 aa. Contains Pfam match to entry PF00009 GTP_EFTU%2C Elongation factor Tu family and PF00679 EFG_C%2C Elongation factor G C-terminus and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0783 SCO0784 SCO0784 3SCF60.16 3SCF60.16 831835 832518 + hypothetical protein 3SCF60.16%2C possible hypothetical protein%2C len: 227 aa. Contains possible N-terminal region signal peptide sequence gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0784 SCO0785 SCO0785 3SCF60.17c 3SCF60.17c 832515 833198 - hypothetical protein 3SCF60.17c%2C possible integral membrane protein%2C len: 227 aa. Contains possible hydrophobic membrane spanning regions gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0785 SCO0786 SCO0786 3SCF60.18 3SCF60.18 833261 833800 + hypothetical protein 3SCF60.18%2C possible integral membrane protein%2C len: 179 aa. Contains possible hydrophobic membrane spanning regions gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0786 SCO0787 SCO0787 3SCF60.19 3SCF60.19 833931 835199 + hydrolase 3SCF60.19%2C probable hydrolase%2C len: 422 aa%3B similar to TR:O68641 (EMBL:AF052745) Oerskovia xanthineolytica beta-1%2C3-glucanase II BglII%2C 435 aa%3B fasta scores: opt: 999 z-score: 1047.9 E(): 0%3B 52.4%25 identity in 443 aa overlap. Contains Pfam match to entry PF00722 Glyco_hydro_16%2C Glycosyl hydrolases family 16 and PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain%2C 3 copies and match to Prosite entry PS01034 Glycosyl hydrolases family 16 active sites. Also contains possible N-terminal region signal peptide sequence gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0787 SCO0788 SCO0788 3SCF60.20c 3SCF60.20c 835238 835474 - hypothetical protein 3SCF60.20c%2C unknown%2C len: 78 aa gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0788 SCO0789 SCO0789 3SCF60.21 3SCF60.21 835547 836665 + hypothetical protein 3SCF60.21%2C conserved hypothetical protein%2C len: 372 aa%3B C-terminal region identical to TR:P72464 (EMBL:Z70724) Streptomyces lividans hypothetical protein ORF1%2C 343 aa and similar to TR:P96221 (EMBL:Z83864) Mycobacterium tuberculosis hypothetical 36.7 kDa protein MTCY01A6.12%2C 335 aa%3B fasta scores: opt: 1286 z-score: 1468.5 E(): 0%3B 61.0%25 identity in 336 aa overlap. Contains Pfam match to entry PF02231 PHP_N%2C PHP domain N-terminal region gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0789 SCO0790 SCO0790 3SCF60.22 3SCF60.22 836721 837377 + hydrolase SCF43.01%2C possible hydrolase%2C partial CDS%2C len: > 98 aa. Identical over the available sequence to Streptomyces lividans TR:P72465(EMBL:Z70724) substrate hyphae associated protein%2C Orf2 (218 aa)%2C fasta scores opt: 648 z-score: 826.2 E(): 0 100.0%25 identity in 98 aa overlap. Also similar to several phosphatases e.g. Streptomyces collinus TR:Q9X654(EMBL:AF131877) NapH phosphatase (231 aa)%2C fasta scores opt: 186 z-score: 245.7 E(): 2.6e-06 41.9%25 identity in 86 aa overlap.~3SCF60.22%2C possible hydrolase (fragment)%2C len: >154 aa%3B identical to N-terminal region of TR:P72465 (EMBL:Z70724) Streptomyces lividans coat protein ORF2%2C 218 aa and similar to TR:Q9RWE0 (EMBL:AE001929) Deinococcus radiodurans hydrolase%2C CbbY/CbbZ/Gph/YirH family DR0729%2C 259 aa%3B fasta scores: opt: 227 z-score: 282.6 E(): 3.3e-08%3B 30.3%25 identity in 152 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0790 SCO0791 SCO0791 SCF43.02 SCF43.02 837541 838680 + hypothetical protein SCF43.02%2C possible integral membrane protein%2C len: 379 aa. Almost identical to Streptomyces lividans TR:P72466(EMBL:Z70724) substrate hyphae associated protein%2C Orf3 (329 aa)%2C fasta scores opt: 2115 z-score: 2334.5 E():0 99.4%25 identity in 329 aa overlap. Also weakly similar to Mycobacterium tuberculosis SW:Y0BU_MYCTU(EMBL:Z77724) hypothetical 36.8 KD protein (355 aa)%2C fasta scores opt: 208 z-score: 236.0 E(): 9.3e-06 26.1%25 identity in 303 aa overlap and to a downstream CDS%2C SCF43.07%2C integral membrane protein (419 aa)%2C fasta scores opt: 276 z-score: 252.1 E(): 1.2e-08 28.1%25 identity in 366 aa overlap. Note SCF43.02 is 50 aa longer than Streptomyces lividans Orf3. Contains possible membrane spanning hydrophobic domains. gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0791 SCO0792 SCO0792 SCF43.03 SCF43.03 838977 840008 + hypothetical protein SCF43.03%2C unknown%2C len: 343 aa. Almost identical to Streptomyces lividans TR:P72467(EMBL:Z70724) substrate hyphae associated protein%2C Orf4 (343 aa)%2C fasta scores opt: 2274 z-score: 2584.7 E():0 99.1%25 identity in 343 aa overlap. Also weakly similar to Streptomyces coelicolor TR:Q9WX08(EMBL:AL079345) epimerase (353 aa)%2C fasta scores opt: 275 z-score: 318.0 E(): 2.5e-10 25.9%25 identity in 340 aa overlap. gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0792 SCO0793 SCO0793 SCF43.04c SCF43.04c 840026 840334 - hypothetical protein SCF43.04c%2C unknown%2C len: 102 aa. gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0793 SCO0794 SCO0794 SCF43.05c SCF43.05c 840399 841688 - transcriptional regulator SCF43.05c%2C possible ROK family transcriptional regulator%2C len: 429 aa. Similar to Anaerocellum thermophilum SW:XYLR_ANATH (EMBL:Z69782) xylose repressor (399 aa)%2C fasta scores opt: 519 z-score: 575.9 E(): 1.1e-24 28.1%25 identity in 402 aa overlap. Also highly similar to Streptomyces coelicolor TR:O87855(EMBL:AL031013) transcriptional regulator SC8A6.21c (441 aa)%2C fasta scores opt: 2034 z-score: 2241.7 E():0 71.4%25 identity in 434 aa overlap. Contains a Pfam match to entry PF00480 ROK%2C ROK family and a helix-turn-helix motif situated between residues 30..51 (+3.09 SD). gene gene780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0794 SCO0795 SCO0795 SCF43.06 SCF43.06 841878 842372 + hypothetical protein SCF43.06%2C unknown%2C len: 164 aa. Highly similar to a protein of unknown function from Streptomyces coelicolor SC1G2.10 (165 aa)%2C fasta scores opt: 663 z-score: 732.7 E():0 60.1%25 identity in 163 aa overlap gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0795 SCO0796 SCO0796 SCF43.07 SCF43.07 842488 843747 + hypothetical protein SCF43.07%2C possible integral membrane protein%2C len: 419 aa. Weakly similar to several proteins of undefined function e.g. Streptomyces lividans TR:P72466(EMBL:Z70724) a substrate hyphae associated protein%2C Orf3 (329 aa)%2C fasta scores opt: opt: 221 z-score: 250.2 E(): 1.5e-06 27.0%25 identity in 318 aa overlap. Also similar to the upstream CDS SCF43.02%2C integral membrane protein (379 aa)%2C fasta scores opt: 276 z-score: 252.1 E(): 1.2e-08 28.1%25 identity in 366 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0796 SCO0797 SCO0797 SCF43.08 SCF43.08 843808 844860 + hypothetical protein SCF43.08%2C possible integral membrane protein%2C len: 350 aa. Contains possible membrane spanning hydrophobic domains and a TTA /leucine codon%2C possible target for bldA regulation. gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0797 SCO0798 SCO0798 SCF43.09 SCF43.09 844881 846116 + hypothetical protein SCF43.09%2C hypothetical protein%2C len: 411 aa. Weakly similar to several proteins of undefined function e.g. Lactococcus lactis TR:O86271(EMBL:AJ001008) OrfB (341 aa)%2C fasta scores opt: 579 z-score: 550.5 E(): 2.8e-23 31.1%25 identity in 347 aa overlap. gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0798 SCO0799 SCO0799 SCF43.10c SCF43.10c 846084 846809 - hypothetical protein SCF43.10c%2C unknown%2C len: 241 aa. Weakly similar to Mycobacterium tuberculosis TR:P96239(EMBL:Z83864) hypothetical 28.3 KD protein (258 aa)%2C fasta scores opt: 270 z-score: 339.5 E(): 1.6e-11 33.5%25 identity in 272 aa overlap. gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0799 SCO0800 SCO0800 SCF43.11c SCF43.11c 846917 847534 - TetR family transcriptional regulator SCF43.11c%2C possible TetR-family transcriptional regulatory protein%2C len: 205 aa. Similar to several including: Escherichia coli SW:ACRR_ECOLI (EMBL:U00734) potential AcrAB operon repressor AcrR (215 aa)%2C fasta scores opt: 176 z-score: 223.7 E(): 4.5e-05 27.5%25 identity in 189 aa overlap and Streptomyces coelicolor TR:Q9XAE5 (EMBL:AL079356) hypothetical 24.2 KD protein SC6G9.37 (217 aa)%2C fasta scores opt: 282 z-score: 351.9 E(): 3.3e-12 33.2%25 identity in 196 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 43..64 (+5.17 SD). gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0800 SCO0801 SCO0801 SCF43.12 SCF43.12 847649 849232 + cytochrome P450 SCF43.12%2C possible cytochrome P450%2C len: 527 aa. Highly similar to the N-terminal P450 domain of Bacillus megaterium SW:CPXB_BACME (EMBL:J04832) cytochrome P450(BM-3) (1048 aa)%2C fasta scores opt: 789 z-score: 839.8 E():0 41.9%25 identity in 497 aa overlap. Also weakly similar to Eukaryotic cytochrome P450 proteins e.g. Homo sapiens (Human) SW:CPF3_HUMAN(EMBL:D12620) cytochrome P450 4F3 (leukotriene-B4 20-monooxygenase) (EC 1.14.13.30) (520 aa)%2C fasta scores opt: 553 z-score: 592.7 E(): 1.2e-25 29.2%25 identity in 390 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 and a Prosite hit to PS00086 Cytochrome P450 cysteine heme-iron ligand signature. gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0801 SCO0802 SCO0802 SCF43.13c SCF43.13c 849194 850042 - hypothetical protein SCF43.13c%2C unknown%2C len: 282 aa. Highly similar to several including: Bacillus megaterium TR:O24772(EMBL:AB005787) oxetanocin A resistance protein%2C OxrA (185 aa)%2C fasta scores opt: 632 z-score: 753.8 E():0 56.8%25 identity in 176 aa overlap and Bacillus subtilis SW:YYBG_BACSU(EMBL:D26185) hypothetical 31.3 KD protein (279 aa)%2C fasta scores opt: 1070 z-score: 1267.0 E():0 59.0%25 identity in 266 aa overlap. Contains 2xPfam matches to entry PF00805 Pentapeptide%2C Pentapeptide repeats (8 copies) gene gene788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0802 SCO0803 SCO0803 SCF43.14c SCF43.14c 850100 851074 - RNA polymerase sigma factor SCF43.14c%2C possible RNA polymerase sigma factor%2C len: 330 aa. Similar to Mycobacterium smegmatis TR:O05767 (EMBL:U87307) extracytoplasmic function alternative sigma factor SigE (204 aa)%2C fasta scores opt: 234 z-score: 278.1 E(): 4.1e-08 29.1%25 identity in 175 aa overlap. Also highly similar to many other sigma factors e.g. Streptomyces coelicolor TR:Q9X8P3 (EMBL:AL049754) RNA polymerase sigma factor SCH10.04C (294 aa)%2C fasta scores opt: 915 z-score: 1056.2 E():0 52.9%25 identity in 293 aa overlap. gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0803 SCO0804 SCO0804 SCF43.15c SCF43.15c 851097 851840 - hypothetical protein SCF43.15c%2C unknown%2C len: 247 aa. Weakly similar to several proteins of undefined function e.g. Pyrococcus horikoshii TR:O58235(EMBL:AP000002) (272 aa) fasta scores opt:323 z-score: 406.6 E(): 2.9e-15 28.2%25 identity in 227 aa overlap. gene gene790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0804 SCO0805 SCO0805 SCF43.16c SCF43.16c 851911 853212 - prolyl aminopeptidase SCF43.16c%2C possible prolyl aminopeptidase%2C len: 433 aa. Highly similar to several peptidases including: Aeromonas sobria SW:PIP_AERSO(EMBL:D30714) proline iminopeptidase (EC 3.4.11.5) (prolyl aminopeptidase) (424 aa)%2C fasta scores opt: 954 z-score: 1113.1 E():0 48.6%25 identity in 428 aa overlap and Hafnia alvei TR:P94800(EMBL:D61383) prolyl aminopeptidase (427 aa)%2C fasta scores opt: 1208 z-score: 1408.6 E():0 47.2%25 identity in 432 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0805 SCO0806 SCO0806 SCF43.17c SCF43.17c 853340 854365 - LacI family transcriptional regulator SCF43.17c%2C possible LacI-family transcriptional regulatory protein%2C len: 341 aa. Similar to many regulators including: Escherichia coli SW:RBSR_ECOLI (EMBL:M13169) ribose operon repressor%2C RbsR (329 aa)%2C fasta scores opt: 646 z-score: 726.9 E(): 0 35.9%25 identity in 334 aa overlap and Streptomyces coelicolor TR:Q9Z509 (EMBL:AL035591) transcriptional regulator (LacI family) SCC54.16 (368 aa)%2C fasta scores opt: 659 z-score: 740.7 E(): 0 39.2%25 identity in 337 aa overlap. Contains a Pfam matches to entries PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family. Also contains a Prosite hit to PS00356 Bacterial regulatory proteins%2C lacI family signature. A helix-turn-helix motif situated between residues 5..26 (+6.47 SD) gene gene792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0806 SCO0807 SCO0807 SCF43.18c SCF43.18c 854455 854775 - hypothetical protein SCF43.18c%2C unknown%2C len: 107 aa. Highly similar to several proteins of unknown function e.g. Escherichia coli SW:YIIL_ECOLI(EMBL:L19201) hypothetical 12.3 KD protein YiiL (104 aa)%2C fasta scores opt: 174 z-score: 248.9 E(): 1.8e-06 31.1%25 identity in 106 aa overlap and Bacillus subtilis TR:O05263(EMBL:Z93938) hypothetical 12.6 KD protein YulD (104 aa)%2C fasta scores opt: 254 z-score: 355.8 E(): 1.9e-12 43.4%25 identity in 106 aa overlap. gene gene793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0807 SCO0808 SCO0808 SCF43.19c SCF43.19c 854802 855884 - solute-binding lipoprotein SCF43.19c%2C possible solute-binding lipoprotein%2C len: 360 aa. Similar to many bacterial extracellular solute-binding proteins including: Bacillus subtilis SW:RBSB_BACSU(EMBL:Z92953) D-ribose-binding protein precursor%2C RbsB (305 aa)%2C fasta scores opt: 234 z-score: 252.1 E(): 1.2e-06 24.9%25 identity in 277 aa overlap and Streptomyces coelicolor TR:CAB56679(EMBL:AL121596) possible solute-binding lipoprotein SCF51A.27 (359 aa)%2C fasta scores opt: 1487 z-score: 1547.8 E(): 0 63.1%25 identity in 360 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0808 SCO0809 SCO0809 SCF43.20c SCF43.20c 856126 857139 - ABC transporter permease SCF43.20c. possible ABC transporter permease%2C len: 337 aa. Similar to many permeases e.g. Bacillus subtilis SW:RBSC_BACSU(EMBL:Z25798) ribose transport system permease RbsC (323 aa)%2C fasta scores opt: 561 z-score: 603.2 E(): 3.3e-26 33.9%25 identity in 295 aa overlap. Also similar to the adjoining CDS%2C SCF43.21c%2C possible ABC transporter permease (346 aa)%2C fasta scores opt: 545 z-score: 528.3 E(): 5e-24 33.4%25 identity in 335 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0809 SCO0810 SCO0810 SCF43.21c SCF43.21c 857132 858172 - ABC transporter permease SCF43.21c. possible ABC transporter permease%2C len: 346 aa. Similar to many permeases e.g. Bacillus subtilis SW:RBSC_BACSU(EMBL:Z25798) ribose transport system permease RbsC (323 aa)%2C fasta scores opt: 591 z-score: 644.0 E(): 1.7e-28 33.4%25 identity in 302 aa overlap and Escherichia coli SW:RBSC_ECOLI(EMBL:L10328) ribose transport system permease RbsC (321 aa)%2C fasta scores opt: 596 z-score: 649.4 E(): 8.6e-29 34.5%25 identity in 304 aa overlap. Also similar to the adjoining CDS%2C SCF43.20c%2C possible ABC transporter permease (346 aa)%2C fasta scores opt: 545 z-score: 528.3 E(): 5e-24 33.4%25 identity in 335 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0810 SCO0811 SCO0811 SCF43.22c SCF43.22c 858169 859686 - ABC transporter ATP-binding protein SCF43A.01c%2C probable ABC transporter ATP-binding protein%2C partial CDS%2C len: >104 aa%3B similar to many e.g. SW:ARAG_ECOLI (EMBL:X06091)%2C araG%2C Escherichia coli L-arabinose transport ATP-binding protein (504 aa)%2C fasta scores%3B opt: 305 z-score: 368.0 E(): 3.6e-13%2C 45.8%25 identity in 96 aa overlap. Similar to many others from S.coelicolor e.g. TR:O50504 (EMBL:AL009199) S.coelicolor probable ABC-transport system ATP binding protein (260 aa) (55.2%25 identity in 96 aa overlap). Contains Pfam match to PF00005 ABC_tran%2C ABC transporter and PS00017 ATP/GTP-binding site motif A (P-loop)~SCF43.22c%2C possible ABC transporter%2C ATP-binding component%2C partial CDS%2C len: > 434 aa. Highly similar to many including: Escherichia coli SW:RBSA_ECOLI(EMBL:M13169) ribose transport ATP-binding protein RbsA (501 aa)%2C fasta scores opt: 1301 z-score: 1408.5 E(): 0 45.7%25 identity in 431 aa overlap and Streptomyces coelicolor TR:O69942(EMBL:AL023862) ABC transporter ATP-binding protein SC3F9.02 (505 aa)%2C fasta scores opt: 1179 z-score: 978.7 E():0 46.0%25 identity in 428 aa overlap. Contains 2x Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and a Prosite hit to PS00211 ABC transporters family signature. gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0811 SCO0812 SCO0812 SCF43A.02 SCF43A.02 859963 861123 + sugar isomerase SCF43A.02%2C possible sugar isomerase%2C len: 386 aa%3B weakly similar to many xylose isomerases (divergent at N- and C-termini) e.g. SW:XYLA_AMPSP (EMBL:M15050)%2C XylA%2C Ampullariella sp. xylose isomerase (394 aa)%2C fasta scores%3B opt: 189 z-score: 229.6 E(): 1.8e-05%2C 26.9%25 identity in 219 aa overlap gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0812 SCO0813 SCO0813 SCF43A.03 SCF43A.03 861242 863281 + short chain dehydrogenase SCF43A.03%2C probable oxidoreductase%2C len: 679 aa%3B similar to many members of the short-chain dehydrogenase/reductase family e.g. SW:YUXG_BACSU (EMBL:Z93938) Bacillus subtilis hypothetical oxidoreductase (689 aa)%2C fasta scores%3B opt: 1727 z-score: 1840.8 E(): 0%2C 40.3%25 identity in 677 aa overlap. C-terminal half is similar to acetoin dehydrogenases e.g. SW:BUDC_KLEPN (EMBL:D86412)%2C BudC%2C Klebsiella pneumoniae acetoin (diacetyl) reductase (256 aa) (35.7%25 identity in 258 aa overlap). C-terminal half is similar to dehydrogenases from S. coelicolor e.g. TR:O88068 (EMBL:AL031541) S.coelicolor probable dehydrogenase (260 aa) (34.3%25 identity in 268 aa overlap). Contains probable coiled-coil from 307 to 334 (28 residues) (Max score: 1.492%2C probability 0.94). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0813 SCO0814 SCO0814 SCF43A.04 SCF43A.04 863278 864732 + rhamnose kinase SCF43A.04%2C probable rhamnose kinase%2C len: 484 aa%3B similar to rhamnose kinases e.g. SW:RHAB_ECOLI (EMBL:L19201)%2C rhaB%2C Escherichia coli rhamnulokinase (489 aa)%2C fasta scores%3B opt: 1136 z-score: 1280.7 E(): 0%2C 41.5%25 identity in 468 aa overlap. Also similar to many other carbohydrate kinases e.g. SW:FUCK_ECOLI (EMBL:X15025)%2C fucK%2C Escherichia coli L-fuculokinase (482 aa) (27.7%25 identity in 411 aa overlap). Contains Pfam match to entry PF00370 FGGY%2C FGGY family of carbohydrate kinases gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0814 SCO0815 SCO0815 SCF43A.05 SCF43A.05 864811 865563 + hypothetical protein SCF43A.05%2C conserved hypothetical protein%2C len: 250 aa%3B unknown function%2C similar to other hypothetical proteins e.g. TR:O07020 (EMBL:Z94043) Bacillus subtilis hypothetical protein (238 aa)%2C fasta scores%3B opt: 720 z-score: 887.0 E(): 0%2C 46.1%25 identity in 245 aa overlap. Also similar to the C-terminal half of many Fe-S proteins e.g. SW:GLPC_ECOLI (EMBL:M20938)%2C glpC%2C Escherichia coli anaerobic glycerol-3-phosphate dehydrogenase subunit C (396 aa) (26.7%25 identity in 255 aa overlap) gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0815 SCO0816 SCO0816 SCF43A.06 SCF43A.06 865560 867038 + iron-sulfur protein SCF43A.06%2C conserved possible iron-sulfur protein%2C len: 492 aa%3B similar to several iron-sulfur proteins e.g. SW:YKGF_ECOLI (EMBL:AE000137) Escherichia coli hypothetical protein (475 aa)%2C fasta scores%3B opt: 1148 z-score: 1249.5 E(): 0%2C 39.7%25 identity in 481 aa overlap%2C which contains 2 4Fe-4S centres. Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0816 SCO0817 SCO0817 SCF43A.07 SCF43A.07 867035 867682 + hypothetical protein SCF43A.07%2C hypothetical protein%2C len: 215 aa%3B unknown function%2C weakly similar to TR:O32259 (EMBL:Z99121) Bacillus subtilis hypothetical protein (240 aa)%2C fasta scores%3B opt: 185 z-score: 226.3 E(): 2.9e-05%2C 27.6%25 identity in 232 aa overlap and to TR:Q9RT57 (EMBL:AE002030) Deinococcus radiodurans conserved hypothetical protein DR1909%2C 212 aa%2C fasta scores: opt: 490 Z-score: 562.1 E(): 1.1e-23%3B 46.893%25 identity in 177 aa overlap gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0817 SCO0818 SCO0818 SCF43A.08 SCF43A.08 867800 868594 + ABC transporter ATP-binding protein SCF43A.08%2C probable ABC transporter ATP-binding protein%2C len: 264 aa%3B similar to many hypothetical ABC transporter ATP-binding proteins e.g. TR:O28803 (EMBL:AE001001) Archaeoglobus fulgidus ABC transporter ATP-binding protein (226 aa)%2C fasta scores%3B opt: 675 z-score: 764.2 E(): 0%2C 48.2%25 identity in 220 aa overlap. Alternative start codons are present at codons 2 and 4. Similar to many from S.coelicolor e.g. TR:O54136 (EMBL:AL021530) S.coelicolor probable ABC-transporter ATP binding protein (230 aa) (44.5%25 identity in 218 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0818 SCO0819 SCO0819 SCF43A.09 SCF43A.09 868598 869908 + transmembrane transport protein SCF43A.09%2C possible transmembrane transport protein%2C len: 436 aa%3B probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains hydrophobic%2C possible membrane-spanning regions. Very weak similarity to TR:O54193 (EMBL:AL021411)%2C cbiM%2C S.coelicolor probable membrane protein (452 aa)%2C fasta scores%3B opt: 139 z-score: 131.9 E(): 0.033%2C 27.8%25 identity in 331 aa overlap. May be involved in membrane transport in association with its upstream neighbour which resembles an ABC-tranporter ATP-binding protein gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0819 SCO0820 SCO0820 SCF43A.10c SCF43A.10c 869978 870337 - hypothetical protein SCF43A.10c%2C unknown%2C len: 119 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0820 SCO0821 SCO0821 SCF43A.11c SCF43A.11c 870420 871397 - threonine dehydratase SCF43A.11c%2C probable threonine dehydratase%2C len: 325 aa%3B similar to many threonine dehydratases e.g. SW:THD2_ECOLI (EMBL:M21312)%2C tdcB%2C Escherichia coli threonine dehydratase catabolic (329 aa)%2C fasta scores%3B opt: 815 z-score: 885.6 E(): 0%2C 42.1%25 identity in 318 aa overlap. Similarity to SW:YKV8_YEAST (EMBL:X75951) Saccharomyces cerevisiae threonine dehydratase homologue (326 aa) is slightly higher (52.9%25 identity in 312 aa overlap). Contains Pfam match to entry PF00291 S_T_dehydratase%2C Pyridoxal-phosphate dependent enzymes and PS00165 Ser/Thr dehydratases pyridoxal-phosphate attachment site gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0821 SCO0822 SCO0822 SCF43A.12c SCF43A.12c 871406 872086 - DNA-binding protein SCF43A.12c%2C possible DNA-binding protein%2C len: 226 aa%3B unknown function%2C weakly similar to SW:YHEO_HAEIN (EMBL:U32739) Haemophilus influenzae hypothetical protein (221 aa)%2C fasta scores%3B opt: 294 z-score: 349.4 E(): 4e-12%2C 25.9%25 identity in 216 aa overlap and SW:YHEO_ECOLI (EMBL:U18997) Escherichia coli hypothetical protein (240 aa) (24.7%25 identity in 223 aa overlap). C-terminal half shows similarity to TR:Q9Z594 (EMBL:AL035478) S.coelicolor possible DNA-binding protein (122 aa) (38.8%25 identity in 80 aa overlap). Contains probable helix-turn-helix motif at aa 193-214 (Score 1406%2C +3.98 SD) gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0822 SCO0823 SCO0823 SCF43A.13 SCF43A.13 872193 872633 + GntR family transcriptional regulator SCF43A.13%2C probable gntR-family transcriptional regulator%2C len: 146 aa%3B weakly similar to transcriptional regulators e.g. TR:Q07191 (EMBL:Z19589)%2C KorSA%2C Streptomyces ambofaciens plasmid pSAM2 transcriptional regulator protein (259 aa)%2C fasta scores%3B opt: 159 z-score: 203.8 E(): 0.00051%2C 32.3%25 identity in 99 aa overlap. Similar to SW:YHCF_BACSU (EMBL:X96983) Bacillus subtilis hypothetical transcriptional regulator (121 aa) (36.8%25 identity in 106 aa overlap). Weakly similar to others from S.coelicolor e.g. SCGD3.13 on cosmid GD3%2C probable gntR-family transcriptional regulator (115 aa) (32.1%25 identity in 112 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0823 SCO0824 SCO0824 SCF43A.14 SCF43A.14 872630 873520 + ABC transporter ATP-binding protein SCF43A.14%2C probable ABC transporter ATP-binding protein%2C len: 296 aa%3B similar to many e.g. SW:NOSF_PSEST (EMBL:X53676)%2C nosF%2C Pseudomonas stutzeri copper transport ATP-binding protein (308 aa)%2C fasta scores%3B opt: 375 z-score: 445.1 E(): 1.8e-17%2C 36.8%25 identity in 223 aa overlap (divergent at the C-terminus). Similar to many from S.coelicolor e.g. SCE7.06c (EMBL:AL049819) probable ABC transporter ATP-binding subunit (276 aa) (40.7%25 identity in 231 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0824 SCO0825 SCO0825 SCF43A.15 SCF43A.15 873517 874473 + transmembrane transport protein SCF43A.15%2C possible transmembrane transport protein%2C len: 318 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains hydrophobic%2C possible membrane-spanning regions. May be involved in membrane transport in association with its upstream neighbour which resembles an ABC-tranporter ATP-binding protein gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0825 SCO0826 SCO0826 SCF43A.16 SCF43A.16 874543 875343 + hypothetical protein SCF43A.16%2C hypothetical protein%2C len: 266 aa%3B unknown function%2C shares short internal regions of similarity with several methyltransferases e.g. TR:O82434 (EMBL:AF053766) Nicotiana tabacum S-adenosyl-methionine cycloartenol-C24-methyltransferase (349 aa)%2C fasta scores%3B opt: 165 z-score: 206.0 E(): 0.00038%2C 29.8%25 identity in 104 aa overlap. Weakly similar to part of SC1E6.19C (EMBL:AL033505) S.coelicolor hypothetical protein (273 aa) (35.1%25 identity in 131 aa overlap) gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0826 SCO0827 SCO0827 SCF43A.17c SCF43A.17c 875388 875726 - hypothetical protein SCF43A.17c%2C unknown%2C len: 112 aa%3B unknown function%2C probable CDS suggested by GC frameplot and amino acid composition gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0827 SCO0828 SCO0828 SCF43A.18 SCF43A.18 875839 877500 + alkaline phosphatase SCF43A.18%2C probable alkaline phosphatase%2C len: 553 aa%3B similar to SW:PPBD_BACSU (EMBL:U49060)%2C PhoD%2C Bacillus subtilis alkaline phosphatase D precursor (556 aa)%2C fasta scores%3B opt: 1512 z-score: 1782.1 E(): 0%2C 47.8%25 identity in 485 aa overlap gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0828 SCO0829 SCO0829 SCF43A.19 SCF43A.19 877702 879078 + serine protease SCF43A.19%2C probable serine protease%2C len: 458 aa%3B similar to many serine proteases e.g. SW:PRTC_STRGR (EMBL:L29018)%2C SprC%2C Streptomyces griseus serine protease C precursor (457 aa)%2C fasta scores%3B opt: 1563 z-score: 1510.8 E(): 0%2C 54.1%25 identity in 449 aa overlap. Both have a C-terminal region similar to part of some chitinases e.g. SW:CHI1_BACCI (EMBL:M57601)%2C chiA1%2C Bacillus circulans chitinase A1 precursor%2C which is not found in the other similar serine proteases. The Thr/Pro-rich 19-amino acid linker region previously identified in SW:PRTC_STRGR is shortened in the S.coelicolor homologue. Contains probable N-terminal signal sequence. Weakly similar to TR:O54109 (EMBL:AL021529) S.coelicolor probable protease (411 aa) (29.4%25 identity in 418 aa overlap). Contains Pfam match to entry PF00089 trypsin%2C Trypsin and PS00135 Serine proteases%2C trypsin family%2C serine active site gene gene815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0829 SCO0830 SCO0830 SCF43A.20c SCF43A.20c 879140 880219 - penicillin-binding protein SCF43A.20c%2C possible penicillin-binding protein%2C len: 359 aa%3B weakly similar to penicillin-binding proteins%2C carboxypeptidases and beta-lactamases e.g. SW:AMPH_ECOLI (EMBL:AE000144)%2C AmpH%2C Escherichia coli penicillin-binding protein (376 aa)%2C fasta scores%3B opt: 274 z-score: 305.5 E(): 1.1e-09%2C 26.5%25 identity in 343 aa overlap%2C SW:DAC_STRSQ (EMBL:M26842) Streptomyces sp. D-alanyl-D-alanine carboxypeptidase precursor (406 aa) (23.8%25 identity in 344 aa overlap) and SW:AMPC_PSEAE (EMBL:X54719)%2C AmpC%2C Pseudomonas aeruginosa beta-lactamase precursor (397 aa) (27.3%25 identity in 381 aa overlap). Weakly similar to others from S. coelicolor e.g. TR:O86739 (EMBL:AL031035) S. coelicolor probable peptidase (386 aa) (26.6%25 identity in 369 aa overlap) and SCH24.34 (EMBL:AL049826) S. coelicolor possible beta-lactamase (461 aa) (31.4%25 identity in 325 aa overlap) gene gene816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0830 SCO0831 SCO0831 SCF43A.21c SCF43A.21c 880216 881136 - hypothetical protein SCF43A.21c%2C hypothetical protein%2C len: 306 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Similar to the adjacent protein SCF43A.22c%2C hypothetical protein (321 aa)%2C fasta scores%3B opt: 674 z-score: 697.3 E(): 1.1e-33%2C 41.3%25 identity in 300 aa overlap gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0831 SCO0832 SCO0832 SCF43A.22c SCF43A.22c 881133 882098 - hypothetical protein SCF43A.22c%2C hypothetical protein%2C len: 321 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Similar to the adjacent protein SCF43A.21c%2C hypothetical protein (306 aa)%2C fasta scores%3B opt: 674 z-score: 666.6 E(): 5.5e-32%2C 41.3%25 identity in 300 aa overlap gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0832 SCO0833 SCO0833 SCF43A.23c SCF43A.23c 882095 882805 - hypothetical protein SCF43A.23c%2C unknown%2C len: 236 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0833 SCO0834 SCO0834 SCF43A.24c SCF43A.24c 882826 883014 - hypothetical protein SCF43A.24c%2C unknown%2C len: 62 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. An alternative start codon is present at codon 7%2C but without an apparent RBS gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0834 SCO0835 SCO0835 SCF43A.25c SCF43A.25c 883113 883760 - methyltransferase SCF43A.25c%2C possible methyltransferase%2C len: 215 aa%3B weakly similar to methyltransferases e.g. SW:UBIG_ECOLI (EMBL:Y00544)%2C UbiG%2C Escherichia coli 3-demethylubiquinone-9 3-methyltransferase (240 aa)%2C fasta scores%3B opt: 206 z-score: 249.1 E(): 1.5e-06%2C 31.1%25 identity in 148 aa overlap and TR:Q53137 (EMBL:L21196)%2C CobL%2C Rhodococcus erythropolis methyltransferase/decarboxylase (447 aa) (40.6%25 identity in 138 aa overlap) gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0835 SCO0836 SCO0836 SCF43A.26c SCF43A.26c 883920 884921 - hypothetical protein SCF43A.26c%2C conserved possible membrane protein%2C len: 333 aa%3B unknown function%2C similar to (or to part of) many hypothetical proteins of different sizes e.g. TR:Q55987 (EMBL:D64005) Synechocystis sp. hypothetical protein (617 aa)%2C fasta scores%3B opt: 581 z-score: 633.2 E(): 6.2e-28%2C 40.1%25 identity in 232 aa overlap and TR:O05781 (EMBL:Z95150) Mycobacterium tuberculosis hypothetical protein (308 aa) (34.9%25 identity in 301 aa overlap). Contains hydrophobic%2C possible membrane-spanning region. Contains Pfam match to entry PF00924 UPF0003%2C Uncharacterized protein family UPF0003 gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0836 SCO0837 SCO0837 SCF43A.27c SCF43A.27c 885004 885270 - hypothetical protein SCF43A.27c%2C unknown%2C len: 88 aa%3B unknown function%2C improbable Pro/Gln-rich CDS suggested by weak GC frameplot%2C positional base preference and amino acid composition scores gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0837 SCO0838 SCO0838 SCF43A.28 SCF43A.28 885442 885867 + hypothetical protein SCF43A.28%2C conserved hypothetical protein%2C len: 141 aa%3B unknown function%2C similar to SW:YY13_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis hypothetical protein (137 aa)%2C fasta scores%3B opt: 393 z-score: 495.0 E(): 3.1e-20%2C 52.9%25 identity in 121 aa overlap Weakly similar to SC6G9.21 (EMBL:AL079356) S.coelicolor conserved hypothetical protein (144 aa) (35.7%25 identity in 126 aa overlap) gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0838 SCO0839 SCO0839 SCF43A.29c SCF43A.29c 885933 888050 - transmembrane transport protein SCF43A.29c%2C probable transmembrane transport protein%2C len: 705 aa%3B similar to TR:Q53902 (EMBL:M64683) S.coelicolor actII ORF3 antibiotic export protein (711 aa)%2C fasta scores%3B opt: 887 z-score: 912.2 E(): 0%2C 45.3%25 identity in 700 aa overlap and to many transporters and hypothetical proteins. Also similar to TR:O54101 (EMBL:AL021529) S.coelicolor probable export protein (847 aa) (37.2%25 identity in 702 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0839 SCO0840 SCO0840 SCF43A.30c SCF43A.30c 888194 888700 - MarR family transcriptional regulator SCF43A.30c%2C possible marR-family transcriptional regulator%2C len: 168 aa%3B weakly similar to several transcriptional regulators e.g. SW:PECS_ERWCH (EMBL:X74409)%2C PecS%2C Erwinia chrysanthemi regulator of pectinase%2C cellulase%2C and blue pigment production (166 aa)%2C fasta scores%3B opt: 125 z-score: 166.0 E(): 0.064%2C 29.2%25 identity in 89 aa overlap. Also similar to hypothetical proteins e.g. TR:O31472 (EMBL:Z99105) Bacillus subtilis hypothetical protein (155 aa) (35.4%25 identity in 144 aa overlap). Contains Pfam match to PF01047 MarR%2C MarR family Score 30.03 gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0840 SCO0841 SCO0841 SCF43A.31 SCF43A.31 888805 890367 + oxidoreductase SCF43A.31%2C possible oxidoreductase%2C len: 520 aa%3B weakly similar to some oxidoreductases e.g. SW:NUEM_BOVIN (EMBL:X59418) Bos taurus NADH-ubiquinone oxidoreductase 39 kD subunit precursor (380 aa)%2C fasta scores%3B opt: 288 z-score: 319.2 E(): 1.9e-10%2C 23.8%25 identity in 286 aa overlap. Also similar to hypothetical proteins e.g. SW:YBJT_ECOLI (EMBL:AE000188) Escherichia coli hypothetical protein (476 aa) (32.2%25 identity in 490 aa overlap). The N-terminal half is similar to TR:O54156 (EMBL:AL021409) S.coelicolor probable oxidoreductase (347 aa) (31.7%25 identity in 287 aa overlap) gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0841 SCO0842 SCO0842 phr phr 890835 892211 + deoxyribodipyrimidine photolyase SCF43A.32%2C phr%2C probable deoxyribodipyrimidine photolyase%2C len: 458 aa%3B highly similar to many deoxyribodipyrimidine photolyases e.g. SW:PHR_STRGR (EMBL:X15060)%2C phr%2C Streptomyces griseus deoxyribodipyrimidine photolyases (455 aa)%2C fasta scores%3B opt: 2043 z-score: 1879.8 E(): 0%2C 67.1%25 identity in 459 aa overlap. Contains Pfam match to entry PF00875 DNA_photolyase%2C DNA photolyase%2C PS00394 DNA photolyases class 1 signature 1 and PS00691 DNA photolyases class 1 signature 2 gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0842 SCO0843 SCO0843 SCF43A.33c SCF43A.33c 892238 892672 - hypothetical protein SCF43A.33c%2C unknown%2C len: 144 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0843 SCO0844 SCO0844 SCF43A.34c SCF43A.34c 892665 893006 - DNA-binding protein SCF43A.34c%2C possible DNA-binding protein%2C len: 113 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains probable helix-turn-helix motif at aa 9-30 (Score 1062%2C +2.80 SD) gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0844 SCO0845 SCO0845 SCF43A.35c SCF43A.35c 893013 893279 - hypothetical protein SCF43A.35c%2C unknown%2C len: 88 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. The N-terminus is rich in basic amino acids%2C while the remainder is rich in Ser/Thr gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0845 SCO0846 SCO0846 SCF43A.36 SCF43A.36 893386 894186 + hypothetical protein SCF43A.36%2C hypothetical protein%2C len: 266 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0846 SCO0847 SCO0847 SCF43A.37c SCF43A.37c 894244 894702 - lyase SCF43A.37c%2C possible lyase%2C len: 152 aa%3B weakly similar to many lactoylglutathione lyases e.g. SW:LGUL_SALTY (EMBL:U57364)%2C GloA%2C Salmonella typhimurium lactoylglutathione lyase (135 aa)%2C fasta scores%3B opt: 133 z-score: 175.2 E(): 0.02%2C 28.7%25 identity in 136 aa overlap. Weakly similar to SCI7.11c (EMBL:AL096743) S.coelicolor possible lyase (130 aa) (28.3%25 identity in 127 aa overlap). An alternative start codon is present at codon 3 gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0847 SCO0848 SCO0848 SCM2.01c SCM2.01c 894818 895819 - oxidoreductase SCM2.01c%2C possible oxidoreductase%2C len: 333 aa. Similar to many including several from eukaryotes e.g. Mus musculus (Mouse) SW:QOR_MOUSE(EMBL:S70056) quinone oxidoreductase (EC 1.6.5.5) (331 aa)%2C fasta scores opt: 499 z-score: 508.7 E(): 5.9e-21 30.5%25 identity in 331 aa overlap. Also similar to several from Prokaryotes e.g. Streptomyces coelicolor TR:Q53927(EMBL:X62373) hydroxyacyl-CoA dehydrogenase involved in actinorhodin biosynthesis (329 aa)%2C fasta scores opt: 481 z-score: 490.8 E(): 5.8e-20 35.8%25 identity in 338 aa overlap. Contains a Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0848 SCO0849 SCO0849 SCM2.02c SCM2.02c 895829 896353 - hypothetical protein SCM2.02c%2C possible membrane protein%2C len: 174 aa. Contains possible membrane spanning hydrophobic domains. gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0849 SCO0850 SCO0850 SCM2.03 SCM2.03 896543 896968 + hypothetical protein SCM2.03%2C possible membrane protein%2C len: 141 aa. Contains possible membrane spanning hydrophobic domains. gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0850 SCO0851 SCO0851 SCM2.04c SCM2.04c 896973 898037 - PfkB-family carbohydrate kinase SCM2.04c%2C possible PfkB-family carbohydrate kinase%2C len: 354 aa. Similar to many carbohydrate kinases including Bacillus subtilis SW:KDGK_BACSU(EMBL:L47838) 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) KdgK (324 aa)%2C fasta scores opt: 497 z-score: 554.8 E(): 1.6e-23 35.0%25 identity in 311 aa overlap and Bacillus stearothermophilus TR:Q9ZFM1(EMBL:AF098273) 2-keto-3-deoxy-gluconate kinase (314 aa)%2C fasta scores opt: 541 z-score: 603.5 E(): 3.1e-26 36.7%25 identity in 308 aa overlap. Contains a Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase. gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0851 SCO0852 SCO0852 SCM2.05c SCM2.05c 898034 898666 - aldolase SCM2.05c%2C possible aldolase%2C len: 210 aa. Similar to Bacillus subtilis SW:ALKH_BACSU (EMBL:L47838) 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) (196 aa)%2C fasta scores opt: 383 z-score: 406.3 E(): 3e-15 38.5%25 identity in 179 aa overlap. Contains a Pfam match to entry PF01081 Aldolase%2C KDPG and KHG aldolase. gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0852 SCO0853 SCO0853 SCM2.06 SCM2.06 898895 899293 + hypothetical protein SCM2.06%2C possible membrane protein%2C len: 132 aa. Contains a possible membrane spanning hydrophobic domain. gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0853 SCO0854 SCO0854 SCM2.07 SCM2.07 899538 902129 + hypothetical protein SCM2.07%2C unknown%2C len: 863 aa. gene gene840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0854 SCO0855 SCO0855 SCM2.08c SCM2.08c 902174 902680 - acetyltransferase SCM2.08c%2C possible acetyltransferase%2C len: 168 aa. Weak similarity to several other acetyltransferases e.g. Streptomyces coelicolor TR:CAB51273 (EMBL:AL096872) acetyltransferase SC5F7.12C (169 aa)%2C fasta scores opt: 121 z-score: 155.1 E(): 0.29 31.3%25 identity in 147 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0855 SCO0856 SCO0856 SCM2.09c SCM2.09c 902743 903969 - hypothetical protein SCM2.09c possible integral membrane protein%2C len: 408 aa. Contains multiple possible membrane spanning hydrophobic domains. Also contains a TTA /leucine codon%2C which is a possible target for bldA regulation. gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0856 SCO0857 SCO0857 SCM2.10 SCM2.10 904109 904747 + TetR family transcriptional regulator SCM2.10%2C possible TetR-family regulator%2C len: 242 aa. Similar to Streptomyces coelicolor TR:Q9X8G9(EMBL:AL049819) transcriptional regulator SCE7.13c (204 aa)%2C fasta scores opt: 455 z-score: 536.7 E(): 1.6e-22 41.1%25 identity in 202 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and an N-terminal 3x AAG repeat%2C between residues 5..15. gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0857 SCO0858 SCO0858 SCM2.11c SCM2.11c 905000 905377 - hypothetical protein SCM2.11c%2C unknown%2C len: 125 aa. gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0858 SCO0859 SCO0859 SCM2.12c SCM2.12c 905546 906055 - hypothetical protein SCM2.12c%2C possible membrane protein%2C len: 169 aa. . Contains possible hydrophobic membrane spanning region gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0859 SCO0860 SCO0860 SCM2.13c SCM2.13c 906052 908340 - cation-transporting ATPase SCM2.13c%2C probable cation-transporting ATPase%2C len: 762 aa. Highly similar to many other cation transporters e.g. Enterococcus hirae SW:COPA_ENTHR(EMBL:L13292) copper/potassium-transporting ATPase A (EC 3.6.1.36) (727 aa)%2C fasta scores opt: 1287 z-score: 1275.2 E():0 37.8%25 identity in 749 aa overlap. Contains Prosite hits to PS01047 Heavy-metal-associated domain and PS00154 E1-E2 ATPases phosphorylation site. Also contains Pfam matches to entries PF00122 E1-E2_ATPase%2C E1-E2 ATPase and PF00403 HMA%2C Heavy-metal-associated domain as well as multiple possible membrane spanning hydrophobic domains. gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0860 SCO0861 SCO0861 SCM2.14c SCM2.14c 908340 908549 - hypothetical protein SCM2.14c%2C hypothetical protein%2C len: 69 aa. Rich in the amino acid Gly. Contains possible N-terminal region signal peptide sequence gene gene847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0861 SCO0862 SCO0862 SCM2.15c SCM2.15c 908813 909472 - hypothetical protein SCM2.15c%2C possible integral membrane protein%2C len: 219 aa. Similar to a protein of unknown function from Mycobacterium tuberculosis SW:Y970_MYCTU(EMBL:Z79700) hypothetical 22.9 KD protein (210 aa)%2C fasta scores opt: 224 z-score: 235.4 E(): 9.8e-06 30.5%25 identity in 213 aa overlap. Contains possible membrane spanning hydrophobic domains and a a possible N-terminal signal sequence. gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0862 SCO0863 SCO0863 SCM2.16c SCM2.16c 909469 910926 - hypothetical protein SCM2.16c%2C possible integral membrane protein%2C len: 485 aa. Weakly similar to Pseudomonas aeruginosa TR:P72122(EMBL:D28119) OprC outer membrane protein C (471 aa)%2C fasta scores opt: 256 z-score: 271.9 E(): 9.1e-08 28.5%25 identity in 466 aa overlap and to TR:CAC44337 (EMBL:AL596102) Streptomyces coelicolor integral membrane protein SCBAC19F3.14%2C 517 aa%3B fasta scores: opt: 581 Z-score: 603.9 E(): 5.2e-26%3B 46.076%25 identity in 497 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0863 SCO0864 SCO0864 SCM2.17c SCM2.17c 911343 911939 - ECF family RNA polymerase sigma factor SCM2.17c%2C probable ECF-family sigma factor%2C len: 198 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa)%2C fasta scores opt: 268 z-score: 337.2 E(): 2.1e-11 34.3%25 identity in 181 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU (EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa)%2C fasta scores opt: 517 z-score: 643.3 E(): 1.9e-28 50.8%25 identity in 177 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 %25 identity%2C in 197 aa overlap%2C with the downstream gene%2C SCM2.19c. Contains a Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily). gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0864 SCO0865 SCO0865 SCM2.18c SCM2.18c 912092 912862 - hypothetical protein SCM2.18c%2C possible integral-membrane protein%2C len: 278 aa. Similar to Streptomyces coelicolor TR:CAB51458(EMBL:AL096884) membrane protein (236 aa)%2C fasta scores opt: 184 z-score: 201.5 E(): 0.00077 31.3%25 identity in 265 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 40.6 %25 identity%2C in 256 aa overlap%2C with the downstream gene%2C SCM2.20c. Contains a possible N-terminal signal sequence and possible membrane spanning hydrophobic domains. gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0865 SCO0866 SCO0866 SCM2.19c SCM2.19c 912931 913572 - ECF family RNA polymerase sigma factor SCM2.19c%2C probable ECF-family sigma factor%2C len: 213 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa)%2C fasta scores opt: 292 z-score: 354.1 E(): 2.4e-12 35.7%25 identity in 185 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU( EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa)%2C fasta scores opt: 530 z-score: 636.2 E(): 4.6e-28 51.7%25 identity in 178 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 %25 identity%2C in 197 aa overlap%2C with the upstream gene%2C SCM2.17c. Note that the predicted product of SCM2.19c is 17 aa longer than that of SCM2.17c. Contains a Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) and a possible helix-turn-helix motif situated between residues 169..190. gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0866 SCO0867 SCO0867 SCM2.20c SCM2.20c 913768 914472 - hypothetical protein SCM2.20c%2C possible integral-membrane protein%2C len: 234 aa. Similar to Streptomyces coelicolor TR:CAB51458(EMBL:AL096884) membrane protein (236 aa)%2C fasta scores opt: 211 z-score: 247.5 E(): 2.1e-06 28.8%25 identity in 243 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 40.6 %25 identity%2C in 256 aa overlap%2C with the upstream gene%2C SCM2.18c. Contains a possible N-terminal signal sequence and possible membrane spanning hydrophobic domains. gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0867 SCO0868 SCO0868 SCM1.01c SCM1.01c 914827 915270 - regulatory protein SCM1.01c%2C possible regulatory protein%2C len: 147 aa. Similar to Streptomyces fradiae TR:Q9Z9I5 (EMBL:AB024056) regulatory protein (139 aa)%2C fasta scores opt: 166 z-score: 217.5 E(): 9.1e-05 30.9%25 identity in 123 aa overlap and Streptomyces coelicolor A3(2) TR:CAB55834 (EMBL:AJ249581) regulator of sig15 (170 aa)%2C fasta scores opt: 157 z-score: 205.1 E(): 0.00044 32.8%25 identity in 119 aa overlap. gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0868 SCO0869 SCO0869 SCM1.02c SCM1.02c 915341 915715 - anti-sigma factor antagonist SCM1.02c%2C possible anti-sigma factor antagonist%2C len: 124 aa. Weakly similar to several anti anti sigma factors including: Bacillus subtilis SW:SP21_BACSU( EMBL:M17643) anti-sigma F factor antagonist (stage II sporulation protein AA) (116 aa)%2C fasta scores opt: 147 z-score: 204.6 E(): 0.00047 26.6%25 identity in 109 aa overlap and Streptomyces coelicolor A3(2) TR:CAB55835 (EMBL:AJ249581) anti anti sigma factor (125 aa)%2C fasta scores opt: 142 z-score: 197.8 E(): 0.0011 29.8%25 identity in 94 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA%2C SpoIIAA family. gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0869 SCO0870 SCO0870 SCM1.03c SCM1.03c 916336 916785 - two-component system response regulator SCM1.03c%2C probable two-component system response regulator%2C len: 149 aa. Highly similar to the response regulator receiver domains of two-component regulatory proteins including: Synechocystis sp. (strain PCC 6803) TR:P72781(EMBL:D90900) regulatory components of sensory transduction system (282 aa)%2C fasta scores opt: 229 z-score: 290.6 E(): 7.7e-09 31.8%25 identity in 129 aa overlap and Methanobacterium thermoautotrophicum TR:O26545(EMBL:AE000828) sensory transduction regulatory protein (145 aa)%2C fasta scores opt: 422 z-score: 531.6 E(): 2.9e-22 47.2%25 identity in 142 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0870 SCO0871 SCO0871 SCM1.04c SCM1.04c 916782 918377 - two-component sensor protein SCM1.04c%2C possible two-component sensor protein. Len: 545 aa. Similar%2C in parts%2C to many others including: Methanobacterium thermoautotrophicum TR:O26544(EMBL:AE000828) signal-transducing histidine kinase (373 aa)%2C fasta scores opt: 509 z-score: 548.0 E(): 3.5e-23 34.2%25 identity in 313 aa overlap and Streptomyces coelicolor TR:O88056(EMBL:AL031541) two-component sensor (379 aa)%2C fasta scores opt:350 z-score: 378.5 E(): 9.7e-14 35.6%25 identity in 233 aa overlap. Contains a Pfam matches to entries PF00512 signal%2C Histidine kinase and Pfam match to entry PF00672 DUF5%2C Domain found in bacterial signal proteins. Also contains possible membrane spanning hydrophobic regions gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0871 SCO0872 SCO0872 SCM1.05c SCM1.05c 918438 919775 - hypothetical protein SCM1.05c%2C unknown%2C len: 445 aa. Weakly similar to several Streptomyces coelicolor proteins including: TR:O86807(EMBL:AL031031) regulatory protein SC7C7.02C (916 aa)%2C fasta scores opt: 306 z-score: 336.6 E(): 2.1e-11 30.7%25 identity in 264 aa overlap and TR:CAB59599(EMBL:AL132662) hypothetical regulatory protein SCF11.22 (877 aa)%2C fasta scores opt: 284 z-score: 312.7 E(): 4.5e-10 34.6%25 identity in 243 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain. gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0872 SCO0873 SCO0873 SCM1.06c SCM1.06c 919901 920182 - hypothetical protein SCM1.06c%2C doubtful CDS%2C len: 93 aa. gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0873 SCO0874 SCO0874 SCM1.07c SCM1.07c 920727 921419 - hypothetical protein SCM1.07c%2C possible integral membrane protein%2C len: 230 aa. Highly similar to Streptomyces coelicolor TR:Q9X897(EMBL:AL049645) integral membrane protein SCE2.02c (234 aa)%2C fasta scores opt: 1217 z-score: 1265.3 E():0 82.8%25 identity in 233 aa overlap. Also weakly similar to several other proteins of undefined function e.g. Mycobacterium tuberculosis TR:P96876(EMBL:Z92771) hypothetical 23.6 KD protein (222 aa)%2C fasta scores opt: 360 z-score: 447.3 E(): 1.4e-17 33.8%25 identity in 195 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0874 SCO0875 SCO0875 SCM1.08c SCM1.08c 921420 921755 - transcription regulator ArsR SCM1.08c%2C possible ArsR-family transcriptional regulatory protein%2C len: 111 aa. Highly similar to several transcriptional regulatory proteins e.g. Streptomyces lividans SW:MERR_STRLI(EMBL:X65467) probable mercury resistance operon repressor MerR (125 aa)%2C fasta scores opt: 198 z-score: 268.8 E(): 1.3e-07 36.9%25 identity in 103 aa overlap and Mycobacterium tuberculosis SW:YJ94_MYCTU(EMBL:Z74025) hypothetical transcriptional regulator (118 aa)%2C fasta scores opt: 338 z-score: 448.4 E(): 1.2e-17 55.4%25 identity in 92 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X898(EMBL:AL049645) transcriptional regulator SCE2.03C (111 aa)%2C fasta scores opt: 672 z-score: 876.4 E():0 90.1%25 identity in 111 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family and a helix-turn-helix motif situated between residues 35..56 (+3.29 SD). gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0875 SCO0876 SCO0876 SCM1.09c SCM1.09c 921927 922175 - hypothetical protein SCM1.09c%2C unknown%2C len: 82 aa. gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0876 SCO0877 SCO0877 SCM1.10 SCM1.10 922247 924913 + transcriptional regulator SCM1.10%2C possible transcriptional regulatory protein%2C len: 888 aa. Highly similar to many e.g. Streptomyces hygroscopicus TR:Q54307 (EMBL:X86780) regulator of cholesterol oxidase (872 aa)%2C fasta scores opt: 259 z-score: 271.6 E(): 8.8e-08 29.3%25 identity in 916 aa overlap and Streptomyces coelicolor TR:CAB52359 (EMBL:AL109747) probable transcriptional regulator SCJ21.13 (919 aa)%2C fasta scores opt: 780 z-score: 819.1 E():0 37.5%25 identity in 918 aa overlap. Contains a Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible membrane spanning hydrophobic domains. Contains a helix-turn-helix motif situated between residues 836..857 (+4.18 SD) gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0877 SCO0878 SCO0878 SCM1.11 SCM1.11 924917 925795 + hydrolase SCM1.11%2C possible hydrolase%2C len: 292 aa. Highly similar to several including: Streptomyces peucetius TR:Q54809(EMBL:L40425) 10-carbomethoxy-13-deoxycarminomycin esterase (298 aa)%2C fasta scores opt: 670 z-score: 757.9 E():0 40.3%25 identity in 288 aa overlap and Streptomyces purpurascens TR:Q54528(EMBL:U10405:) possible C-C hydrolase%2C RdmC (298 aa) fasta scores opt: 709 z-score: 801.6 E():0 41.2%25 identity in 289 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0878 SCO0879 SCO0879 SCM1.12. SCM1.12. 925792 926569 + gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0879 SCO0880 SCO0880 SCM1.13 SCM1.13 926916 927332 + hypothetical protein SCM1.13%2C possible membrane protein%2C len: 138 aa. Contains a possible membrane spanning hydrophobic domain and an N-terminal signal sequence. gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0880 SCO0881 SCO0881 SCM1.14c SCM1.14c 927534 928499 - hypothetical protein SCM1.14c%2C unknown%2C len: 321 aa. Highly similar to another protein of undefined function from Streptomyces coelicolor TR:CAB56728(EMBL:AL121600) hypothetical 34.3 KD protein SCF76.08C (325 aa)%2C fasta scores opt: 978 z-score: 1133.4 E(): 0 47.2%25 identity in 326 aa overlap gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0881 SCO0882 SCO0882 SCM1.15 SCM1.15 928670 929017 + hypothetical protein SCM1.15%2C unknown%2C len: 115 aa. Highly similar to another protein of undefined function from Streptomyces coelicolor TR:CAB52051(EMBL:AL109732) hypothetical 14.0 KD protein SC7H2.09c (126 aa)%2C fasta scores opt: 234 z-score: 312.6 E(): 4.6e-10 41.8%25 identity in 91 aa overlap. gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0882 SCO0883 SCO0883 def def 929061 929717 + peptide deformylase cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins%3B binds iron(2+) gene gene869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0883 SCO0884 SCO0884 SCM1.17c SCM1.17c 929779 931212 - oxidoreductase SCM1.17c%2C probable oxidoreductase%2C len: 477 aa. Highly similar to many mercuric reductases (EC 1.16.1.1) and to dihydrolipoamide dehydrogenases (EC 1.8.1.4)(both enzyme classes belong to the pyridine nucleotide-disulfide oxidoreductases class-I family): Mycobacterium tuberculosis TR:O07268(EMBL:AL021959) mercuric reductase (499 aa)%2C fasta scores opt: 2030 z-score: 2133.1 E():0 63.2%25 identity in 476 aa overlap and Synechocystis sp. (strain PCC 6803) SW:DLDH_SYNY3(EMBL:D90900) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (473 aa)%2C fasta scores opt: 586 z-score: 619.8 E(): 3.5e-27 29.0%25 identity in 497 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X8C3(EMBL:AL049763) pyridine nucleotide-disulfide oxidoreductase SCE36.10C (454 aa)%2C fasta scores opt: 774 z-score: 650.9 E(): 7e-31 40.3%25 identity in 472 aa overlap. Note that the length of this CDS is more consistent with the dihydrolipoamide dehydrogenases than the mercuric reductases. Contains a Pfam match to entry PF00070 pyr_redox%2C Pyridine nucleotide-disulphide oxidoreductase class-I. gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0884 SCO0885 SCO0885 SCM1.18 SCM1.18 931333 931737 + thioredoxin SCM1.18%2C trxA3%2C thioredoxin%2C len: 134 aa. Highly similar to many thioredoxins e.g. Escherichia coli SW:THI2_ECOLI (EMBL:U85942) thioredoxin 2 (Trx2) (139 aa)%2C fasta scores opt: 280 z-score: 337.5 E(): 1.9e-11 41.6%25 identity in 101 aa overlap. Also similar to Streptomyces coelicolor TR:CAB42711 (EMBL:AL049826) thioredoxin TrxA%2C SCH24.11C (110 aa)%2C fasta scores opt: 224 z-score: 263.9 E(): 2.5e-09 38.7%25 identity in 93 aa overlap. Contains a Prosite hit to PS00194 Thioredoxin family active site and a Pfam match to entry PF00085 thiored%2C Thioredoxin. gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0885 SCO0886 SCO0886 SCM1.19c SCM1.19c 931757 932791 - LacI family transcriptional regulator SCM1.19c%2C possible LacI-family transcriptional regulator%2C len: 344 aa. Similar to many including: Escherichia coli SW:RBSR_ECOLI (EMBL:M13169) ribose operon repressor (329 aa)%2C fasta scores opt: 353 z-score: 387.9 E(): 2.9e-14 30.7%25 identity in 313 aa overlap. Also similar to several Streptomyces coelicolor LacI-family transcriptional regulators e.g. TR:CAB59495 (EMBL:AL132648) (350 aa)%2C fasta scores opt: 377 z-score: 413.3 E(): 1.1e-15 33.9%25 identity in 345 aa overlap and TR:O87600 (EMBL:AF086832) (350 aa)%2C fasta scores opt: 377 z-score: 413.3 E(): 1.1e-15 33.9%25 identity in 345 aa overlap. Contains a Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family with a helix-turn-helix motif situated between residues 19..40 (+5.76 SD). gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0886 SCO0887 SCO0887 SCM1.20c SCM1.20c 932864 933568 - TetR family transcriptional regulator SCM1.20c%2C possible TetR-family transcriptional regulator%2C len: 234 aa. Similar to another Streptomyces coelicolor TetR-family transcriptional regulator TR:CAB58280 (EMBL:AL121849) (194 aa)%2C fasta scores opt: 196 z-score: 233.7 E(): 1.1e-05 30.8%25 identity in 208 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with a helix-turn-helix motif situated between residues 61..82 (+3.80 SD). gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0887 SCO0888 SCO0888 SCM1.21 SCM1.21 933708 934271 + hypothetical protein SCM1.21%2C possible hypothetical protein%2C len: 187 aa. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:P95105 (EMBL:Z83866) hypothetical 19.1 KD protein (184 aa)%2C fasta scores opt: 651 z-score: 722.6 E(): 6.7e-33 56.6%25 identity in 175 aa overlap. Contains a possible N-terminal signal sequence gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0888 SCO0889 SCO0889 SCM1.22c SCM1.22c 934332 935237 - LysR family transcriptional regulator SCM1.22c%2C possible LysR-family transcriptional regulatory protein%2C len: 301 aa. Similar to many other regulatory proteins including: Escherichia coli SW:OXYR_ECOLI (EMBL:J04553) hydrogen peroxide-inducible genes activator (305 aa)%2C fasta scores opt: 348 z-score: 401.9 E(): 4.8e-15 28.4%25 identity in 299 aa overlap and Streptomyces coelicolor TR:O86805 (EMBL:AL031317) transcriptional regulator (306 aa)%2C fasta scores opt: 491 z-score: 563.9 E(): 4.6e-24 36.4%25 identity in 302 aa overlap. Contains a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family%2C with the helix-turn-helix motif situated between residues 17..38 (+3.88 SD). gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0889 SCO0890 SCO0890 SCM1.23c SCM1.23c 935622 936329 - short chain oxidoreductase SCM1.23c%2C possible short chain oxidoreductase%2C len: 235 aa. Similar to several including: Bradyrhizobium japonicum SW:FIXR_BRAJA(EMBL:X06167) FixR protein involved in symbiotic nitrogen fixation (278 aa)%2C fasta scores opt: 262 z-score: 283.4 E(): 1.9e-08 30.8%25 identity in 224 aa overlap and Streptomyces coelicolor TR:CAB56136(EMBL:AL117669) short chain oxidoreductase (299 aa)%2C fasta scores opt: 290 z-score: 311.9 E(): 5e-10 38.6%25 identity in 233 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0890 SCO0891 SCO0891 SCM1.24 SCM1.24 936431 937270 + DNA-binding protein SCM1.24%2C possible DNA-binding protein%2C len: 279 aa. Highly similar to many Streptomyces coelicolor DNA-binding proteins e.g. TR:CAB53273 (EMBL:AL109972) SCJ9A.12C (279 aa)%2C fasta scores opt: 564 z-score: 639.5 E(): 2.8e-28 37.2%25 identity in 269 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a Prosite hit to PS00092 N-6 Adenine-specific DNA methylases signature. The helix-turn-helix motif is situated between residues 35..56 (+4.25 SD) gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0891 SCO0892 SCO0892 SCM1.25c SCM1.25c 937290 938240 - hypothetical protein SCM1.25c%2C possible integral membrane protein%2C len: 316 aa. Highly similar to several other membrane proteins including: Serratia marcescens SW:TERC_SERMA(EMBL:L38824) tellurium resistance protein TerC (346 aa)%2C fasta scores opt: 381 z-score: 448.5 E(): 1.2e-17 32.3%25 identity in 325 aa overlap and Streptomyces coelicolor TR:Q9Z503(EMBL:AL035591) integral membrane export protein SCC54.23c (333 aa)%2C fasta scores opt: 1690 z-score: 1964.9 E(): 0 79.1%25 identity in 316 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0892 SCO0893 SCO0893 SCM1.26 SCM1.26 938389 939612 + hypothetical protein SCM1.26%2C possible membrane protein%2C len: 407 aa. Weakly similar to a hypothetical protein from Synechocystis sp. (strain PCC 6803) TR:P72959(EMBL:D90902) (343 aa)%2C fasta scores opt: 215 z-score: 248.3 E(): 1.8e-06 28.7%25 identity in 352 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0893 SCO0894 SCO0894 SCM1.27 SCM1.27 939627 941063 + hypothetical protein SCM1.27%2C possible membrane protein%2C len: 478 aa. Contains possible membrane spanning hydrophobic domain. gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0894 SCO0895 SCO0895 hrdC hrdC 941071 942090 - RNA polymerase principal sigma factor HrdC SCM1.28c%2C hrdC%2C RNA polymerase principal sigma factor HrdC%2C len: 339 aa. Previously sequenced and characterised Streptomyces coelicolor strain A3(2) SW:HRDC_STRCO(EMBL:X52981). Contains a Pfam match to entry PF00140 sigma70%2C Sigma-70 factor. The helix-turn-helix motif is situated between residues 298..319 (+6.49 SD). gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0895 SCO0896 SCO0896 SCM1.29c SCM1.29c 942453 942878 - oxidoreductase SCM1.29c%2C possible oxidoreductase%2C len: 141 aa. Similar to many including Methanopyrus kandleri SW:IMDH_METKA (EMBL:U31567) inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (172 aa)%2C fasta scores opt: 227 z-score: 288.9 E(): 9.5e-09 31.6%25 identity in 117 aa overlap and Bacillus subtilis SW:YHCV_BACSU (EMBL:X96983) hypothetical 14.9 KD protein (140 aa)%2C fasta scores opt: 295 z-score: 372.8 E(): 2e-13 40.0%25 identity in 135 aa overlap. Contains 2x Pfam match to entry PF00571 CBS%2C CBS domains. gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0896 SCO0897 SCO0897 SCM1.30c SCM1.30c 942974 943567 - hypothetical protein SCM1.30c%2C unknown%2C len: 197 aa%3B similar to the plasmid borne TR:CAC48467 (EMBL:AL603642) Rhizobium meliloti (Sinorhizobium meliloti) hypothetical protein SMB20067%2C 173 aa%3B fasta scores: opt: 483 Z-score: 502.3 E(): 2.4e-20%3B 51.370%25 identity) in 146 aa overlap gene gene883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0897 SCO0898 SCO0898 SCM1.31c SCM1.31c 943851 945833 - regulator SCM1.31c%2C possible regulator%2C len: 660 aa. Similar to many other regulators including several from Streptomyces coelicolor e.g. SW:AFSR_STRCO (EMBL:D90155) regulatory protein AfsR (993 aa)%2C fasta scores opt: 531 z-score: 560.0 E(): 7.5e-24 31.9%25 identity in 568 aa overlap and TR:Q9Z389(EMBL:AL035654) transcriptional regulator SCE8.10 (638 aa)%2C fasta scores opt: 430 z-score: 456.1 E(): 4.6e-18 31.2%25 identity in 385 aa overlap. gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0898 SCO0899 SCO0899 SCM1.32 SCM1.32 946045 946941 + hydrolase SCM1.32%2C possible hydrolase%2C len: 298 aa. Similar to many including: Moraxella sp. SW:DEH1_MORSP (EMBL:D90422:) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa)%2C fasta scores opt: 669 z-score: 782.5 E():0 39.2%25 identity in 296 aa overlap and Streptomyces coelicolor TR:O86546 (EMBL:AL031350) hydrolase SC1F2.09C (309 aa)%2C fasta scores opt: 336 z-score: 396.1 E(): 1e-14 31.1%25 identity in 305 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0899 SCO0900 SCO0900 SCM1.33 SCM1.33 947027 948310 + transmembrane efflux protein SCM1.33%2C possible transmembrane efflux protein%2C len: 427 aa. Similar to several other membrane transport proteins including: Francisella tularensis TR:AAC12938(EMBL:AF055345) tetracycline-resistance protein (396 aa)%2C fasta scores opt: 230 z-score: 259.1 E(): 4.4e-07 25.4%25 identity in 397 aa overlap and Streptomyces flavopersicus TR:AAD45543(EMBL:U70376) spectinomycin export protein%2C SpcT (433 aa)%2C fasta scores opt: 467 z-score: 520.7 E(): 1.2e-21 30.7%25 identity in 394 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0900 SCO0901 SCO0901 SCM1.34c SCM1.34c 948674 949762 - hypothetical protein SCM1.34c%2C unknown%2C len: 362 aa. Contains an inverted repeat. gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0901 SCO0902 SCO0902 SCM1.35c SCM1.35c 949864 950292 - hypothetical protein SCM1.35c%2C unknown%2C len: 142 aa. Similar to the C-terminus of several catechol 2%2C3-dioxygenases e.g. Sphingomonas sp. A8AN3 TR:Q9ZAY3(EMBL:U73127) catechol 2%2C3-dioxygenase (307 aa)%2C fasta scores opt:128 z-score: 160.4 E():0.14 31.2%25 identity in 141 aa overlap. gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0902 SCO0903 SCO0903 SCM1.36 SCM1.36 950551 950811 + hypothetical protein SCM1.36%2C unknown%2C len: 86 aa. gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0903 SCO0904 SCO0904 SCM1.37 SCM1.37 950823 951122 + hypothetical protein SCM1.37%2C possible hypothetical protein%2C len: 99 aa. Contains a possible N-terminal signal sequence. gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0904 SCO0905 SCO0905 SCM1.38 SCM1.38 951217 951522 + hypothetical protein SCM1.38%2C possible membrane protein%2C len: 101 aa. Highly similar to the very C-terminus of Streptomyces coelicolor SW:MMLA_STRCO(EMBL:M64683) membrane protein ACTII-3 (711 aa)%2C fasta scores opt: 232 z-score: 254.6 E(): 7.8e-07 48.3%25 identity in 87 aa overlap. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain. gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0905 SCO0906 SCO0906 SCM1.39c SCM1.39c 951452 951949 - hypothetical protein SCM1.39c%2C unknown%2C len: 165 aa. Weakly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:O53240(EMBL:AL021287) hypothetical 18.2 KD protein (163 aa)%2C fasta scores opt: 148 z-score: 178.3 E(): 0.014 30.9%25 identity in 139 aa overlap. gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0906 SCO0907 SCO0907 SCM1.40c SCM1.40c 951968 952858 - dehydrogenase SCM1.40c%2C possible dehydrogenase%2C len: 296 aa. Similar to many including: Pseudomonas cruciviae TR:Q9ZNH7 (EMBL:AB015439) D-threonine dehydrogenase (fragment) (292 aa)%2C fasta scores opt: 458 z-score: 510.7 E(): 4.5e-21 33.0%25 identity in 297 aa overlap. gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0907 SCO0908 SCO0908 SCM1.41 SCM1.41 952991 953455 + hypothetical protein SCM1.41%2C unknown%2C len: 154 aa. Similar to the C-terminus of a protein of unknown function in Mycobacterium tuberculosis TR:P71738(EMBL:Z81368) (189 aa)%2C fasta scores opt: 451 z-score: 544.4 E(): 5.6e-23 48.7%25 identity in 154 aa overlap gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0908 SCO0909 SCO0909 SCM1.42c SCM1.42c 953440 954429 - hypothetical protein SCM1.42c%2C hypothetical protein%2C len: 329 aa%3B similar to TR:Q9RZM4 (EMBL:AE001826) Deinococcus radiodurans hypothetical protein DRB0099%2C 285 aa%3B fasta scores: opt: 634 Z-score: 682.1 E(): 2.3e-30%3B 46.642%25 identity in 268 aa overlap gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0909 SCO0910 SCO0910 SCM1.43 SCM1.43 954566 955867 + hypothetical protein SCM1.43%2C unknown%2C len: 433 aa. Similar to a hypothetical protein from Mycobacterium tuberculosis TR:O69672 (EMBL:AL022121) (432 aa)%2C fasta scores opt: 687 z-score: 787.6 E():0 37.5%25 identity in 421 aa overlap. Also similar to the C-terminus of several Eukaryotic gamma-glutamylcysteine synthetases involved in the de novo synthesis of glutathione in plant chloroplasts%2C e.g. Brassica juncea (Indian mustard) SW:GSH1_BRAJU(EMBL:Y10848) glutamate-cysteine ligase precursor (EC 6.3.2.2) (514 aa)%2C fasta scores opt: 428 z-score: 490.5 E(): 6.1e-20 30.4%25 identity in 362 aa overlap gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0910 SCO0911 SCO0911 SCM1.44 SCM1.44 955864 957204 + hypothetical protein SCM1%2C44%2C unknown%2C len: 446 aa. Similar to several proteins of undefined function e.g. from Mycobacterium tuberculosis TR:O69671(EMBL:AL022121) hypothetical 47.1 KD protein (425 aa)%2C fasta scores opt: 1480 z-score: 1643.4 E():0 53.9%25 identity in 421 aa overlap. gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0911 SCO0912 SCO0912 SCM1.45 SCM1.45 957204 958019 + hypothetical protein SCM1.45%2C unknown%2C len: 271 aa. Similar to several proteins of undefined function including: Mycobacterium tuberculosis TR:O69670(EMBL:AL022121) hypothetical 24.6 KD protein (233 aa)%2C fasta scores opt: 383 z-score: 443.9 E(): 2.2e-17 44.8%25 identity in 252 aa overlap. Also weakly similar to several Eukaryotic proteins e.g. Saccharomyces cerevisiae SW:YNT1_YEAST(EMBL:Z71467) hypothetical 40.2 KD protein (357 aa)%2C fasta scores opt: 221 z-score: 257.3 E(): 5.5e-07 26.1%25 identity in 306 aa overlap. gene gene898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0912 SCO0913 SCO0913 SCM1.46 SCM1.46 958016 958987 + hypothetical protein SCM10.01%2C hypothetical protein (partial CDS)%2C len: >115 aa%3B similar to various hypothetical proteins%2C e.g. TR:O69669 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 35.4 kD protein MTV025.049c%2C 321 aa%3B fasta scores: opt: 413 z-score: 559.6 E(): 8.8e-24%3B 59.8%25 identity in 112 aa overlap~SCM1.46%2C hypothetical protein%2C partial CDS%2C len: > 251 aa. Similar to several proteins of undefined function including: Mycobacterium tuberculosis TR:O69669(EMBL:AL022121) hypothetical 35.4 KD protein (321 aa)%2C fasta scores opt: 897 z-score: 1053.0 E():0 59.9%25 identity in 242 aa overlap and Synechocystis sp. (strain PCC 6803) TR:P73759(EMBL:D90909) hypothetical 38.0 KD protein (337 aa)%2C fasta scores opt: 646 z-score:759.9 E():0 47.4%25 identity in 232 aa overlap. gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0913 SCO0914 SCO0914 SCM10.02c SCM10.02c 959024 960292 - lipoprotein SCM10.02c%2C possible lipoprotein%2C len: 422 aa%3B similar to TR:CAB59588 (EMBL:AL132662) Streptomyces coelicolor sugar transporter sugar binding protein SCF11.11%2C 422 aa%3B fasta scores: opt: 1543 z-score: 1682.7 E(): 0%3B 57.6%25 identity in 427 aa overlap and to SW: MALE_ENTAE Enterobacter aerogenes maltose-binding periplasmic protein precursor MalE%2C 396 aa%3B fasta scores: opt: 224 z-score: 248.5 E(): 1.9e-06%3B 23.9%25 identity in 427 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and match correctly situated to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0914 SCO0915 SCO0915 SCM10.03 SCM10.03 960501 960758 + hypothetical protein SCM10.03%2C unknown%2C len: 85 aa%3B similar to TR:O53714 (EMBL:AL021931) Mycobacterium tuberculosis MTV036.14 possible protein transport protein%2C 71 aa%3B fasta scores: opt: 96 z-score: 153.6 E(): 0.36%3B 24.2%25 identity in 62 aa overlap gene gene901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0915 SCO0916 SCO0916 SCM10.04c SCM10.04c 960792 961283 - hypothetical protein SCM10.04c%2C unknown%2C len: 163 aa gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0916 SCO0917 SCO0917 SCM10.05 SCM10.05 961534 962553 + oxygenase SCM10.05%2C possible oxygenase%2C len: 339 aa%3B similar to TR:Q9X2P4 (EMBL:AF041061) Mycobacterium smegmatis alkanal monooxygenase-like hypothetical protein AmlP%2C 289 aa%3B fasta scores: opt: 269 z-score: 305.4 E(): 1.3e-09%3B 29.2%25 identity in 291 aa overlap and to SW:LUXA_VIBHA (EMBL:M10961) Vibrio harveyi alkanal monooxygenase alpha chain (EC 1.14.14.3) LuxA%2C 355 aa%3B fasta scores: opt: 208 z-score: 236.6 E(): 8.6e-06%3B 27.8%25 identity in 205 aa overlap. Contains Pfam match to entry PF00296 bac_luciferase%2C Bacterial luciferase gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0917 SCO0918 SCO0918 SCM10.06 SCM10.06 962596 964941 + excinuclease ABC subunit A SCM10.06%2C probable excinuclease ABC subunit A%2C len: 781 aa%3B similar to SW:UVRA_PSELE (EMBL:Z22595) Pseudomonas lemoignei excinuclease ABC subunit A (fragment) UvrA%2C 689 aa%3B fasta scores: opt: 1263 z-score: 1326.5 E(): 0%3B 57.5%25 identity in 670 aa overlap%2C to SW:UVRA_MICLU (EMBL:X15867) Micrococcus luteus excinuclease ABC subunit A UvrA%2C 992 aa%3B fasta scores: opt: 1096 z-score: 1149.1 E(): 0%3B 40.9%25 identity in 962 aa overlap and to S. coelicolor SC5F2A.02c%2C 752 aa%3B fasta scores: opt: 1207 z-score: 981.3 E(): 0%3B 44.8%25 identity in 772 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter%2C two matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and another two to Prosite entry PS00211 ABC transporters family signature gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0918 SCO0919 SCO0919 SCM10.07c SCM10.07c 964984 965943 - hypothetical protein SCM10.07c%2C unknown%2C len: 319 aa. Contains glycine/alanine rich region gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0919 SCO0920 SCO0920 SCM10.08c SCM10.08c 966016 966843 - acyltransferase SCM10.08c%2C probable acyltransferase%2C len: 260 aa%3B similar to SW:PLSC_NEIGO (EMBL:U21806) Neisseria gonorrhoeae 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)PlsC%2C 255aa%3B fasta scores: opt: 384 z-score: 454.1 E(): 6.7e-18%3B 38.9%25 identity in 185 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase%2C Acyltransferase. Contains possible hydrophobic membrane spanning region gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0920 SCO0921 SCO0921 SCM10.09c SCM10.09c 966843 967613 - hypothetical protein SCM10.09c%2C hypothetical protein%2C len: 256 aa%3B similar to TR:O53274 (EMBL:AL021287) Mycobacterium tuberculosis hypothetical 27.0 kD protein%2C 246 aa%3B fasta scores: opt: 498 z-score: 593.9 E(): 1.1e-25%3B 47.7%25 identity in 237 aa overlap gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0921 SCO0922 SCO0922 SCM10.10c SCM10.10c 967895 968641 - succinate dehydrogenase/fumarate reductase iron-sulfur subunit catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0922 SCO0923 SCO0923 sdhA sdhA 968638 970587 - succinate dehydrogenase flavoprotein subunit part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers)%3B SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556%3B SdhC binds ubiquinone%3B oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0923 SCO0924 SCO0924 SCM10.12c SCM10.12c 970589 971320 - cytochrome B subunit SCM10.12c%2C possible cytochrome B subunit subunit%2C len: 243 aa%3B similar to SW:FRDC_HELPY (EMBL:U78101) Helicobacter pylori fumarate reductase cytochrome B subunit FrdC%2C 255aa%3B fasta scores: opt: 106 z-score: 139.5 E(): 2.2%3B 22.1%25 identity in 181 aa overlap gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0924 SCO0925 SCO0925 SCM10.13 SCM10.13 971392 972276 + LysR family transcriptional regulator SCM10.13%2C probable lysR-family transcriptional regulator%2C len: 294 aa%3B similar to SW:GLTC_BACSU (EMBL:M28509) Bacillus subtilis transcriptional regulator protein GltC%2C 300 aa%3B fasta scores: opt: 539 z-score: 638.5 E(): 3.6e-28%3B 33.6%25 identity in 283 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains a possible helix-turn-helix motif at residues 16..37 (+4.14 SD) gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0925 SCO0926 SCO0926 SCM10.14c SCM10.14c 972311 973210 - hypothetical protein SCM10.14c%2C hypothetical protein%2C len: 299 aa%3B similar to TR:CAB58282 (EMBL:AL121850) Streptomyces coelicolor conserved hypothetical protein SCC78.01c (fragment)%2C 234 aa%3B fasta scores: opt: 221 z-score: 264.8 E(): 2.3e-07%3B 30.0%25 identity in 250 aa overlap gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0926 SCO0927 SCO0927 SCM10.15 SCM10.15 973388 974224 + LysR family transcriptional regulator SCM10.15%2C probable lysR-family transcriptional regulator%2C len: 278 aa%3B similar to TR:CAB55655 (EMBL:AL117385) Streptomyces coelicolor lysR-family transcriptional regulator SC5G9.07c%2C 287 aa%3B fasta scores: opt: 598 z-score: 666.9 E(): 9.3e-30%3B 47.9%25 identity in 286 aa overlap and to SW:ALSR_BACSU (EMBL:L04470) Bacillus subtilis ALS operon regulatory protein AlsR%2C 302 aa%3B fasta scores: opt: 398 z-score: 446.6 E(): 1.7e-17%3B 37.6%25 identity in 186 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and two mathces to Prosite entries PS00044 Bacterial regulatory proteins%2C lysR family signature and PS00216 Sugar transport proteins signature 1. Contains also a helix-turn-helix motif at residues 16..37 (+5.84 SD) gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0927 SCO0928 SCO0928 SCM10.16c SCM10.16c 974312 976456 - hypothetical protein SCM10.16c%2C hypothetical protein%2C len: 714 aa%3B similar to C-terminal region of TR:Q55576 (EMBL:D63999) Synechocystis sp. hypothetical 141.7 kD protein%2C 1244 aa%3B fasta scores: opt: 1179 z-score: 1354.7 E(): 0%3B 37.6%25 identity in 574 aa overlap and to S. coelicolor SC8D9.07 phosphodiesterase%2C 746 aa%3B fasta scores: opt: 817 z-score: 782.4 E(): 0%3B 41.8%25 identity in 452 aa overlap. Contains Pfam matches to entries PF00989 PAS%2C PAS domain%2C PF00785 PAC%2C PAC motif%2C PF00990 DUF9%2C Domain of unknown function and PF00563 DUF2%2C Domain of unknown function 2 gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0928 SCO0929 SCO0929 SCM10.17c SCM10.17c 976453 977265 - hypothetical protein SCM10.17c%2C hypothetical protein%2C len: 270 aa%3B similar to various S. coelicolor hypothetical proteins%2C e.g. TR:O86540 (EMBL:AL031350) Streptomyces coelicolor hypothetical 32.8 kD protein SC1F2.03c%2C 300 aa%3B fasta scores: opt: 713 z-score: 830.1 E(): 0%3B 45.0%25 identity in 262 aa overlap gene gene915 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0929 SCO0930 SCO0930 SCM10.18c SCM10.18c 977491 978444 - lipoprotein SCM10.18c%2C possible lipoprotein%2C len: 317 aa. Contains possible N-terminal region signal peptide sequence and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0930 SCO0931 SCO0931 SCM10.19 SCM10.19 978713 979324 + proline-rich protein SCM10.19%2C possible proline-rich protein%2C len: 203 aa. Contains possible N-terminal signal peptide sequence and proline-rich region (giving similarities to proline-rich regions in many other proteins) and transmembrane domain at C-terminal region gene gene917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0931 SCO0932 SCO0932 SCM10.20 SCM10.20 979340 980104 + hypothetical protein SCM10.20%2C possible integral membrane protein%2C len: 254 aa. Contains possible N-terminal region signal peptide sequence gene gene918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0932 SCO0933 SCO0933 SCM10.21 SCM10.21 980316 980834 + lipoprotein SCM10.21%2C possible lipoprotein%2C len: 172 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0933 SCO0934 SCO0934 SCM10.22c SCM10.22c 980917 981558 - hypothetical protein SCM10.22c%2C possible integral membrane protein%2C len: 213 aa. Contains possible hydrophobic membrane spanning regions gene gene920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0934 SCO0935 SCO0935 SCM10.23 SCM10.23 981742 982407 + hypothetical protein SCM10.23%2C possible hypothetical protein%2C len: 221 aa. Contains N-terminal region signal peptide sequence gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0935 SCO0936 SCO0936 SCM10.24c SCM10.24c 982439 983044 - oligosaccharide deacetylase SCM10.24%2C probable oligosaccharide deacetylase%2C len: 201 aa%3B similar to SW:NODB_RHIGA (EMBL:X87578) Rhizobium galegae chitooligosaccharide deacetylase (EC 3.5.1.-) (nodulation protein B) NodB%2C 214 aa%3B fasta scores: opt: 461 z-score: 581.4 E(): 5.4e-25%3B 45.1%25 identity in 153 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet%2C Polysaccharide deacetylase gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0936 SCO0937 SCO0937 SCM10.25 SCM10.25 983389 983850 + hypothetical protein SCM10.25%2C hypothetical protein%2C len: 153 aa%3B similar to various hypothetical proteins%2C e.g. TR:BAA86264 (EMBL:AB023785) Streptomyces griseus ORF2%2C 173 aa%3B fasta scores: opt: 218 z-score: 266.9 E(): 1.8e-07%3B 35.5%25 identity in 138 aa overlap gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0937 SCO0938 SCO0938 SCM10.26 SCM10.26 983971 985377 + amino acid transporter SCM10.26%2C probable amino acid transporter%2C len: 468 aa%3B similar to TR:O69844 (EMBL:AL023702) Streptomyces coelicolor cationic amino acid transporter SC1C3.02%2C 503 aa%3B fasta scores: opt: 829 z-score: 890.5 E(): 0%3B 45.9%25 identity in 490 aa overlap and to SW:CTR2_HUMAN (EMBL:D29990) Homo sapiens (Human) low-affinity cationic amino acid transporter-2 AtrC2%2C 658 aa%3B fasta scores: opt: 446 z-score: 480.4 E(): 2.3e-19%3B 32.8%25 identity in 430 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and match to Prosite entry PS00165 Ser/Thr dehydratases pyridoxal-phosphate attachment site gene gene924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0938 SCO0939 SCO0939 SCM10.27c SCM10.27c 985374 986237 - hydrolase SCM10.27c%2C probable hydrolase%2C len: 287 aa%3B similar to TR:CAB56657 (EMBL:AL121596) Streptomyces coelicolor hydrolase SCF51A.05%2C 278 aa%3B fasta scores: opt: 325 z-score: 381.1 E(): 7.7e-14%3B 32.9%25 identity in 283 aa overlap and to SW:PRXC_STRAU (EMBL:AF031242) Streptomyces aureofaciens non-heme chloroperoxidase (EC 1.11.1.10) CpoT%2C 278 aa%3B fasta scores: opt: 239 z-score: 282.3 E(): 2.5e-08%3B 30.4%25 identity in 253 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0939 SCO0940 SCO0940 SCM10.28 SCM10.28 986247 986720 + MarR family regulatory protein SCM10.28%2C possible marR-family regulatory protein%2C len: 157 aa%3B weakly similar to TR:O07458 (EMBL:U75363) Rhodopseudomonas palustris regulatory protein%2C 175 aa%3B fasta scores: opt: 150 z-score: 189.7 E(): 0.0036%3B 28.1%25 identity in 160 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0940 SCO0941 SCO0941 SCM10.29c SCM10.29c 986722 987876 - lipoprotein SCM10.29c%2C possible lipoprotein%2C len: 384 aa%3B weakly similar to SW:CAPA_BACAN (EMBL:M24150) Bacillus anthracis CapA protein%2C 411 aa%3B fasta scores: opt: 270 z-score: 296.6 E(): 4e-09%3B 24.0%25 identity in 338 aa overlap. Contains match correctly situated to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal peptide sequence gene gene927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0941 SCO0942 SCO0942 SCM10.30 SCM10.30 988130 988684 + RNA polymerase sigma factor SigL Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B in M. tuberculosis this protein regulates polyketide synthases and or membrane proteins gene gene928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0942 SCO0943 SCO0943 SCM10.31 SCM10.31 988826 989341 + hypothetical protein SCM10.31%2C unknown%2C len: 171 aa gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0943 SCO0944 SCO0944 SCM10.32 SCM10.32 989560 990210 + hypothetical protein SCM1032%2C possible membrane protein%2C len: 216 aa%3B similar to TR:O53799 (EMBL:AL021958) Mycobacterium tuberculosis%2C and Mycobacterium bovis hypothetical 25.9 kD protein MTV041.10%2C 250 aa%3B fasta scores: opt: 180 z-score: 217.2 E(): 0.0001%3B 34.3%25 identity in 216 aa overlap and to S. coelicolor StF56.17%2C 250 aa%3B fasta scores: opt: 137 z-score: 133.5 E(): 0.05%3B 31.2%25 identity in 247 aa overlap gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0944 SCO0945 SCO0945 SCM10.34c SCM10.34c 990249 991112 - formamidopyrimidine-DNA glycosylase SCM10.34c%2C probable formamidopyrimidine-DNA glycosylase len: 287 aa%3B similar to TR:P71565 (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 16.5k kD protein MTYC10D7.30c%2C 158 aa%3B fasta scores: opt: 608 z-score: 707.4 E(): 5.2e-32%3B 59.0%25 identity in 156 aa overlap and to SW:FPG_SYNEN (EMBL:Y10290) Synechococcus elongatus naegeli formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) MutM%2C 284 aa%3B fasta scores: opt: 426 z-score: 495.1 E(): 3.4e-20%3B 33.6%25 identity in 283 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco%2C Formamidopyrimidine-DNA glycosylase gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0945 SCO0946 SCO0946 SCM10.35c SCM10.35c 991153 993243 - regulatory protein SCM11.01c%2C hypothetical protein%2C len: >587 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9ZBJ0 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.20%2C 860 aa%3B fasta scores: opt: 588 z-score: 654.5 E(): 4.4e-29%3B 30.4%25 identity in 542 aa overlap~SCM10.35c%2C possible regulatory protein%2C (partial CDS)%2C len: >141 aa%3B similar to TR:Q9ZBT2 (EMBL:AL034446)Streptomyces coelicolor regulatory protein SC1A9.20%2C 135 aa%3B fasta scores: opt: 286 z-score: 366.0 E(): 5.3e-13%3B 42.4%25 identity in 132 aa overlap gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0946 SCO0947 SCO0947 SCM11.02 SCM11.02 993366 994778 + hypothetical protein SCM11.02%2C possible integral membrane protein%2C len: 470 aa%3B similar to TR:P96418 (EMBL:Z92669) Mycobacterium tuberculosis hypothetical 54.8 kD protein MTCY08D5.31c%2C 482 aa%3B fasta scores: opt: 2112 z-score: 2527.5 E(): 0%3B 61.9%25 identity in 472 aa overlap and to TR:O69633 (EMBL:AL022121) Mycobacterium tuberculosis peptide transport system permease%3B fasta scores: opt: 122 z-score: 149.8 E(): 0.58%3B 27.7%25 identity in 166 aa overlap gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0947 SCO0948 SCO0948 SCM11.03c SCM11.03c 994798 997821 - alpha-mannosidase SCM11.03c%2C possible alpha-mannosidase%2C len: 1007 aa%3B similar to TR:AAC00190 (EMBL:AF044414) Homo sapiens alpha-mannosidase 6A8B%2C 1062 aa%3B fasta scores: opt: 1326 z-score: 1446.5 E(): 0%3B 37.8%25 identity in 1013 aa overlap and to SW:MAN1_RAT (EMBL:M57547) Rattus norvegicus alpha-mannosidase (EC 3.2.1.24)%2C 1040 aa%3B fasta scores: opt: 1285 z-score: 1401.8 E(): 0%3B 35.9%25 identity in 1041 aa overlap gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0948 SCO0949 SCO0949 SCM11.04c SCM11.04c 997963 999210 - hypothetical protein SCM11.04c%2C hypothetical protein%2C len: 415 aa%3B similar to TR:CAB56687 (EMBL:AL121596) Streptomyces coelicolor hypothetical 71.4 kD protein SCF51A.35%2C 644 aa%3B fasta scores: opt: 205 z-score: 234.7 E(): 1.1e-05%3B 26.0%25 identity in 408 aa overlap gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0949 SCO0950 SCO0950 SCM11.05c SCM11.05c 999242 1000162 - transport system permease SCM11.05c%2C probable transport system permease%2C len: 306 aa%3B similar to TR:P73854 (EMBL:D90910) Synechocystis sp. lactose transport system permease LacG%2C 270 aa%3B fasta scores: opt: 688 z-score: 826.9 E(): 0%3B 39.2%25 identity in 273 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0950 SCO0951 SCO0951 SCM11.06c SCM11.06c 1000159 1001091 - transport system permease SCM11.06c%2C probable transport system permease%2C len: 310 aa%3B similar to TR:P73352 (EMBL:D90905) Synechocystis sp. lactose transport system permease LacF%2C 298 aa%3B fasta scores: opt: 750 z-score: 885.7 E(): 0%3B 44.9%25 identity in 292 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and to prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0951 SCO0952 SCO0952 SCM11.07c SCM11.07c 1001098 1002390 - solute-binding protein SCM11.07c%2C possible solute-binding protein%2C len: 430 aa%3B similar to TR:P73325 (EMBL:D90905) Synechocystis sp SrrA%2C 433 aa%3B fasta scores: opt: 611 z-score: 678.3 E(): 2.1e-30%3B 29.8%25 identity in 430 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and possible N-terminal region signal peptide sequence gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0952 SCO0953 SCO0953 SCM11.08 SCM11.08 1002624 1003673 + LacI family transcriptional regulator SCM11.08%2C probable lacI-family transcriptional regulator%2C len: 349 aa%3B similar to TR:O86598 (EMBL:AL031514) Streptomyces coelicolor transcriptional regulator%2C SC2H4.15%2C 342 aa%3B fasta scores opt: 949 z-score: 1067.0 E(): 0%3B 44.6%25 identity in 341 aa overlap and to SW:ASCG_ECOLI (EMBL:M73326) Escherichia coli cryptic asc operon repressor%2C 336 aa%3B fasta scores: opt: 409 z-score: 463.9 E(): 1.8e-18%3B 28.4%25 identity in 334 aa overlap. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C score 37.90%2C E-value 3.1e-09 and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and Prosite match to entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Contains also a possible helix-turn-helix motif at residues 11..32 (+5.76 SD) gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0953 SCO0954 SCO0954 SCM11.09c SCM11.09c 1003996 1004478 - acetyltransferase SCM11.09c%2C possible acetyltransferase%2C len: 160 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q51670 (EMBL:U34346) Paracoccus denitrificans hypothetical 18.8 kD protein%2C 173 aa%3B fasta scores: opt: 427 z-score: 515.7 E(): 2.4e-21%3B 45.3%25 identity in 161 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0954 SCO0955 SCO0955 SCM11.10c SCM11.10c 1004534 1004710 - hypothetical protein SCM11.10c%2C unknown%2C len: 58 aa gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0955 SCO0956 SCO0956 SCM11.11 SCM11.11 1005186 1005641 + hypothetical protein SCM11.11%2C unknown%2C len: 151 aa gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0956 SCO0957 SCO0957 SCM11.12c SCM11.12c 1005700 1007202 - oxidoreductase SCM11.12c%2C possible oxidoreductase%2C len: 500 aa%3B C-terminus similar to SW:OXIR_STRAT (EMBL:M96551) Streptomyces antibioticus probable oxidoreductase (EC 1.-.-.-)%2C 298 aa%3B fasta scores: opt: 169 z-score: 197.8 E(): 0.0012%3B 32.0%25 identity in 150 aa overlap gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0957 SCO0958 SCO0958 SCM11.13c SCM11.13c 1007306 1008646 - hypothetical protein SCM11.13c%2C hypothetical protein%2C len: 446 aa%3B similar to various Mycobacterium tuberculosis hypothetical proteins%2C e.g. TR:O07035 (EMBL:Z95150) Mycobacterium tuberculosis hypothetical 50.7 kD protein RV3130c%2C 463 aa%3B fasta scores: opt: 491 z-score: 529.2 E(): 4.3e-22%3B 30.2%25 identity in 464 aa overlap gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0958 SCO0959 SCO0959 SCM11.14c SCM11.14c 1008835 1011153 - hypothetical protein SCM11.14c%2C possible hypothetical protein%2C len: 772 aa%3B similar to N-terminus of TR:O69822 (EMBL:AL023496) Streptomyces coelicolor hypothetical protein SC1A6.17c%2C 2314 aa%3B fasta scores: opt: 444 z-score: 500.2 E(): 1.8e-20%3B 30.0%25 identity in 818 aa overlap and low similarities to TR: (EMBL:) Pseudomonas sp. acetaldehyde dehydrigenase (acylating) PhnI%2C 312 aa%3B fasta scores: opt: 125 z-score: 146.1 E(): 0.92%3B 23.7%25 identity in 177 aa overlap . Contains possible signal peptide sequence gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0959 SCO0960 SCO0960 SCM11.15c SCM11.15c 1011212 1013830 - hydrolase SCM11.15c%2C possible hydrolase (hypothetical protein)%2C len: 872 aa%3B similar to TR:Q9X0F2 (EMBL:AE001766) Thermotoga maritima beta-glucuronidase TM1062%2C 563 aa%3B fasta scores: opt: 420 z-score: 447.6 E(): 1.5e-17%3B 28.3%25 identity in 406 aa overlap and to SW:BGLR_ECOLI (EMBL:M14641) Escherichia coli beta-glucuronidase (EC 3.2.1.31) UidA or GusA or GurA%2C 603 aa%3B fasta scores: opt: 359 z-score: 382.2 E(): 6.6e-14%3B 26.2%25 identity in 454 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0960 SCO0961 SCO0961 glgC glgC 1014030 1015250 - glucose-1-phosphate adenylyltransferase catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate gene gene947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0961 SCO0962 SCO0962 glgA glgA 1015300 1016463 - glycosyl transferase SCM11.17c%2C glgA%2C glycosyl transferase%2C len: 387 aa%3B identical to previously sequenced TR:Q9X9U5 (EMBL:AJ243803) Streptomyces coelicolor glycosyl transferase%2C GlgA%2C 387 and similar to TR:Q9X7Z1 (EMBL:AL049497) Streptomyces coelicolor glycosyl transferase SC6G10.05c%2C 412 aa%3B fasta scores: opt: 352 z-score: 421.1 E(): 4.4e-16%3B 29.3%25 identity in 403 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0962 SCO0963 SCO0963 SCM11.18c SCM11.18c 1016501 1017394 - hypothetical protein SCM11.18c%2C hypothetical protein%2C len: 297 aa%3B C-terminal region identical to previously sequenced TR:Q9X9U6 (EMBL:AJ243803) Streptomyces coelicolor hypothetical 18.7 kD protein (fragment)%2C 181 aa. Contains proline-rich C-terminal region gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0963 SCO0964 SCO0964 SCM11.19c SCM11.19c 1017707 1018138 - hypothetical protein SCM11.19c%2C unknown%2C len: 143 aa gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0964 SCO0965 SCO0965 SCM11.20c SCM11.20c 1018179 1018838 - hypothetical protein SCM11.20c%2C conserved hypothetical protein%2C len: 219 aa%3B similar to TR:O50637 (EMBL:AB010203) Leptospira interrogans hypothetical 23.2 kD protein%2C 216 aa%3B fasta scores: opt: 197 z-score: 222.5 E(): 5.1e-05%3B 27.5%25 identity in 182 aa overlap and to TR:Q98N90 (EMBL:AP002994) Rhizobium loti (Mesorhizobium loti) MLL0243 protein%2C 231 aa%3B fasta scores: opt: 545 Z-score: 593.3 E(): 2e-25%3B 48.00%25 identity in 200 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0965 SCO0966 SCO0966 SCM11.21c SCM11.21c 1018944 1019903 - dehydratase SCM11.21c%2C probable dehydratase%2C len: 319 aa%3B similar to TR:Q9Y7K4 (EMBL:AL049495) Schizosaccharomyces pombe hypothetical 31.5 kD protein%2C 295 aa%3B fasta scores opt: 478 z-score: 525.2 E(): 7.1e-22%3B 40.1%25 identity in 312 aa overlap and to TR:O69128 (EMBL:AF064070) Burkholderia pseudomallai epimerase/dehydratase WbiG%2C 321 aa%3B fasta scores: opt: 231 z-score: 257.9 E(): 5.5e-07%3B 26.8%25 identity in 314 aa overlap. Contains match to Prosite entry PS00059 Zinc-containing alcohol dehydrogenases signature gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0966 SCO0967 SCO0967 SCM11.22c SCM11.22c 1019971 1020594 - reductase SCM11.22c%2C possible reductase%2C len: 207 aa%3B similar to SW:F4RE_METJA (EMBL:U67591) Methanococcus jannaschii F420-dependent NADP reductase (EC 1.-.-.-) MJ1501%2C 223 aa%3B fasta scores: opt: 209 z-score: 243.7 E(): 3.4e-06%3B 27.9%25 identity in 197 aa overlap and to SCM11.25c%2C 207 aa%3B fasta scores: opt: 761 z-score: 757.9 E(): 0%3B 60.3%25 identity in 204 aa overlap gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0967 SCO0968 SCO0968 SCM11.23c SCM11.23c 1020695 1021237 - hypothetical protein SCM11.23c%2C hypothetical protein%2C len: 180 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9ZBF0 (EMBL:AL035206) Streptomyces coelicolor hypothetical 31.5 kD protein%2C 289 aa%3B fasta scores: opt: 162 z-score: 182.7 E(): 0.0085%3B 34.0%25 identity in 147 aa overlap gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0968 SCO0969 SCO0969 SCM11.24c SCM11.24c 1021386 1022009 - reductase SCM11.24c%2C possible reductase%2C len: 207 aa%3B similar to SW:F4RE_METJA (EMBL:U67591) Methanococcus jannaschii F420-dependent NADP reductase (EC 1.-.-.-) MJ1501%2C 223 aa%3B fasta scores: opt: 169 z-score: 190.2 E(): 0.0032%3B 27.0%25 identity in 200 aa overlap and to SCM11.23c%2C 207 aa%3B fasta scores: opt: 761 z-score: 742.1 E(): 0%3B 60.3%25 identity in 204 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0969 SCO0970 SCO0970 SCM11.25c SCM11.25c 1022079 1022813 - dehydrogenase/reductase SCM11.25c%2C probable dehydrogenase/reductase ( hypothetical protein)%2C len: 244 aa%3B similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor oxidoreductase SCJ11.40%2C 250 aa%3B fasta scores: opt: 526 z-score: 621.9 E(): 2.9e-27%3B 42.1%25 identity in 242 aa overlap and to SW:DHG3_BACME (EMBL:D10625) Bacillus megaterium glucose 1-dehydrogenase III (EC 1.1.1.47) GdhIII%2C 261 aa%3B fasta scores: opt: 430 z-score: 509.8 E(): 5.1e-21%3B 36.4%25 identity in 247 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. Contains possible N-terminal region signal peptide sequence gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0970 SCO0971 SCO0971 SCM11.26 SCM11.26 1023053 1023964 + LysR family transcriptional regulator SCM11.26%2C probable lysR-family trancsriptional regulator%2C len: 303 aa%3B similar to TR:Q9X9U9 (EMBL:Y18817) Streptomyces coelicolor transcriptional regulator of lysR family%2C 307 aa%3B fasta scores: opt: 502 z-score: 591.8 E(): 1.4e-25%3B 41.9%25 identity in 284 aa overlap and to SW:TFDT_ALCEU (EMBL:U16782) Alcaligenes eutrophus transcriptional regulatory protein TfdT%2C 228 aa%3B fasta scores: opt: 408 z-score: 484.4 E(): 1.3e-19%3B 42.6%25 identity in 204 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains a possible helix-turn-helix motif at residues 18..39 (+4.71 SD) gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0971 SCO0972 SCO0972 SCM11.27 SCM11.27 1024039 1024383 + transposase remnant SCM11.27%2C probable transposase remnant%2C len: 114 aa%3B similar to TR:CAB52928 (EMBL:AL109949) Streptomyces coelicolor transposase (fragment) SCJ11.43c%2C 86 aa%3B fasta scores: opt: 292 z-score: 351.4 E(): 3.4e-12%3B 74.1%25 identity in 58 aa overlap and to SW:YI21_BURCE (EMBL:M64065) Burkholderia cepacia (Pseudomonas cepacia) insertion element IS402 hypothetical 24 kD protein%2C 211 aa%3B fasta scores: opt: 227 z-score: 271.9 E(): 9.1e-08%3B 59.6%25 identity in 57 aa overlap gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0972 SCO0973 SCO0973 SCM11.28 SCM11.28 1024508 1025767 + hypothetical protein SCM11.28%2C probable integral membrane protein%2C len: 419 aa%3B similar to various integral membran proteins%2C e.g. TR:Q9XAN8 (EMBL:AL079355) Streptomyces coelicolor integral membrane protein SC4C6.02c%2C 317 aa%3B fasta scores: opt: 674 z-score: 607.8 E(): 1.8e-26%3B 43.6%25 identity in 326 aa overlap gene gene959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0973 SCO0974 SCO0974 SCBAC19F3.01c SCBAC19F3.01c 1025757 1027076 - hypothetical protein SCBAC19F3.01c%2C possible hypothetical protein%2C len: >237aa: interesting similarity to TR:O86308 (EMBL:Z96935) a resuscitation-promoting factor from Micrococcus luteus (220 aa) fasta scores%3B opt: 499%2C Z-score: 540.6%2C 41.784%25 identity (45.408%25 ungapped) in 213 aa overlap. Similar to many others eg. TR:Q9F2Q2 (EMBL:AL442120) hypothetical protein from Streptomyces coelicolor (244 aa) fasta scores%3B opt: 461%2C Z-score: 499.7%2C 44.033%25 identity (51.442%25 ungapped) in 243 aa overlap. Contains Pfam match to entry PF01476 LysM%2C LysM domain and has a possible N-terminal signal sequence.~SCM11.29c%2C probable hypothetical protein (partial CDS)%2C len: >234 aa%3B similar to TR:Q9X7W8 (EMBL:AL049485) Streptomyces coelicolor peptidase SC6A5%2C 312 aa%3B fast ascores: opt: 684 z-score: 619.7 E(): 3.9e-27%3B 55.2%25 identity in 183 aa overlap and to SW:ALE1_STACP (EMBL:D86328) Staphylococcus capitis glycyl-glycine endopeptidase Ale-1 precursor (EC 3.4.24.75)%2C 362 aa%3B fasta scores: opt: 313 z-score: 291.5 E(): 7.4e-09%3B 29.3%25 identity in 229 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0974 SCO0975 SCO0975 SCBAC19F3.02 SCBAC19F3.02 1027393 1028832 + 6-phosphogluconate dehydrogenase catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate gene gene961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0975 SCO0976 SCO0976 SCBAC19F3.03c SCBAC19F3.03c 1028822 1029955 - hypothetical protein SCBAC19F3.03c%2C unknown%2C len: 377 aa: no significant database matches. Alanine-rich C-terminal region. gene gene962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0976 SCO0977 SCO0977 SCBAC19F3.04c SCBAC19F3.04c 1029991 1030341 - hypothetical protein SCBAC19F3.04c%2C conserved hypothetical protein%2C len: 116aa: similar to many eg. TR:Q9RTC1 (EMBL:AE002024) conserved hypothetical protein from Deinococcus radiodurans (93 aa) fasta scores%3B opt: 176%2C Z-score: 229.5%2C 34.091%25 identity (35.294%25 ungapped) in 88 aa overlap and TR:Q9AJZ8 (EMBL:AL512944) conserved hypothetical protein SC8D11.21 from Streptomyces coelicolor (112 aa) fasta scores%3B opt: 169%2C Z-score: 220.0%2C 34.862%25 identity (38.776%25 ungapped) in 109 aa overlap. gene gene963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0977 SCO0978 SCO0978 panD panD 1030387 1030806 - aspartate alpha-decarboxylase Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0978 SCO0979 SCO0979 SCBAC19F3.06c SCBAC19F3.06c 1031136 1031372 - hypothetical protein SCBAC19F3.06c%2C doubtful CDS%2C len: 78aa: no significant database matches. gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0979 SCO0980 SCO0980 SCBAC19F3.07 SCBAC19F3.07 1031600 1031956 + acyl-CoA thioesterase SCBAC19F3.07%2C partial CDS%2C len: 119aa: similar to N-terminus of many eg. SW:P49851 (YKHA_BACSU) acyl-CoA thioester hydrolase from Bacillus subtilis (179 aa) fasta scores%3B opt: 240%2C Z-score: 251.9%2C 39.815%25 identity (40.187%25 ungapped) in 108 aa overlap. gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0980 SCO0981 SCO0981 SCBAC19F3.08c SCBAC19F3.08c 1031976 1033445 - DNA-binding protein SCBAC19F3.08c%2C possible DNA-binding protein%2C len: 489aa: similar to many eg. TR:AAK44705 (EMBL:AE006950) DNA-binding protein MT0481 from Mycobacterium tuberculosis (474 aa) fasta scores%3B opt: 1753%2C Z-score: 1963.4%2C 56.780%25 identity (58.009%25 ungapped) in 472 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0981 SCO0982 SCO0982 aceA aceA 1033827 1035107 + isocitrate lyase Catalyzes the first step in the glyoxalate cycle%2C which converts lipids to carbohydrates gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0982 SCO0983 SCO0983 aceB2 aceB2 1035208 1036800 + malate synthase Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0983 SCO0984 SCO0984 SCBAC19F3.11 SCBAC19F3.11 1036797 1037666 + 3-hydroxybutyryl-CoA dehydrogenase converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0984 SCO0985 SCO0985 metE metE 1038243 1040561 + 5-methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0985 SCO0986 SCO0986 SCBAC19F3.13 SCBAC19F3.13 1040764 1041465 + hypothetical protein SCBAC19F3.13%2C possible integral membrane protein%2C len: 233aa: similar to others from Streptomyces coelicolor eg. TR:Q9RCU4 (EMBL:AL136149) integral membrane protein (234 aa) fasta scores%3B opt: 315%2C Z-score: 347.2%2C 34.632%25 identity (37.559%25 ungapped) in 231 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0986 SCO0987 SCO0987 SCBAC19F3.14 SCBAC19F3.14 1041692 1043245 + hypothetical protein SCBAC19F3.14%2C possible integral membrane protein%2C len: 517aa: similar to many eg. TR:Q9RCU8 (EMBL:AL136149) integral membrane protein from Streptomyces coelicolor (485 aa) fasta scores%3B opt: 581%2C Z-score: 572.1%2C 46.076%25 identity (48.211%25 ungapped) in 497 aa overlap. Contains possible membrane-spanning hydrophobic regions gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0987 SCO0988 SCO0988 2SCG2.01 2SCG2.01 1043277 1043969 + acetyltransferase 2SCG2.01%2C possible acetyltransferase%2C len: 230 aa. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0988 SCO0989 SCO0989 2SCG2.02c 2SCG2.02c 1043990 1044394 - hypothetical protein 2SCG2.02c%2C unknown%2C len: 134 aa gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0989 SCO0990 SCO0990 2SCG2.03c 2SCG2.03c 1044679 1045668 - hypothetical protein 2SCG2.03c%2C possible integral membrane protein%2C len: 329 aa. Contains possible hydrophobic membrane spanning regions gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0990 SCO0991 SCO0991 2SCG2.04 2SCG2.04 1046251 1047114 + hypothetical protein 2SCG2.04%2C conserved hypothetical protein%2C len: 287 aa%3B similar to TR:Q9XDM4 (EMBL:AF026270) Salmonella enterica serovar Typhimurium hypothetical protein PduX%2C 300 aa%3B fasta scores: opt: 217 z-score: 267.6 E(): 2.2e-07%3B 27.1%25 identity in 266 aa overlap gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0991 SCO0992 SCO0992 2SCG2.05 2SCG2.05 1047111 1048133 + cysteine synthase 2SCG2.05%2C possible cysteine synthase%2C len: 340 aa%3B similar to SW:CYSM_ALCEU (EMBL:X97499) Alcaligenes eutrophus cysteine synthase (EC 4.2.99.8) CysM%2C 339 aa%3B fasta scores: opt: 283 z-score: 331.0 E(): 6.5e-11%3B 30.3%25 identity in 277 aa overlap. Contains Pfam match to entry PF00291 PALP%2C Pyridoxal-phosphate dependent enzyme. Also contains TTA leucine codon (115)%2C possible target for bldA regulation gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0992 SCO0993 SCO0993 2SCG2.06 2SCG2.06 1048130 1049368 + hypothetical protein 2SCG2.06%2C conserved hypothetical protein%2C len: 412 aa%3B similar to SW:Y4RH_RHISN (EMBL:AE000094) Rhizobium sp. hypothetical 52.5 kDa protein Y4rH%2C 478 aa%3B fasta scores: opt: 348 z-score: 384.2 E(): 7.1e-14%3B 26.3%25 identity in 400 aa overlap gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0993 SCO0994 SCO0994 2SCG2.07 2SCG2.07 1049361 1050626 + hypothetical protein 2SCG2.07%2C possible integral membrane protein%2C len: 421 aa%3B similar to TR:O86692 (EMBL:AL031371) Streptomyces coelicolor transport system permease SC4G2.20%2C 436 aa%3B fasta scores: opt: 354 z-score: 396.0 E(): 1.6e-14%3B 29.6%25 identity in 429 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0994 SCO0995 SCO0995 2SCG2.08 2SCG2.08 1050595 1051344 + methyltransferase 2SCG2.08%2C possible methyltransferase%2C len: 249 aa%3B similar to TR:P72459 (EMBL:Y08763) Streptomyces griseus methyltransferase StsG%2C 253 aa%3B fasta scores: opt: 337 z-score: 418.3 E(): 8.9e-16%3B 28.9%25 identity in 242 aa overlap. Contains Pfam match to entry PF01209 Ubie_methyltran%2C ubiE/COQ5 methyltransferase family gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0995 SCO0996 SCO0996 2SCG2.09 2SCG2.09 1051613 1052656 + lipoprotein 2SCG2.09%2C possible lipoprotein%2C len: 347 aa%3B similar to TR:Q9K467 (EMBL:AL359215) Streptomyces coelicolor iron transport lipoprotein SC2H12.17%2C 345 aa%3B fasta scores: opt: 473 z-score: 540.7 E(): 1.4e-22%3B 39.2%25 identity in 339 aa overlap. Contains Pfam match to entry PF01497 Peripla_BP_2%2C Periplasmic binding protein%2C correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0996 SCO0997 SCO0997 2SCG2.10 2SCG2.10 1052653 1053768 + Fe uptake system integral membrane protein 2SCG2.10%2C ftrD%2C Fe uptake system integral membrane protein%2C len: 371 aa%3B previously sequenced and annotated as TR:Q9X471 (EMBL:AF099015) Streptomyces coelicolor Fe uptake system integral membrane protein FtrD%2C 374 aa and similar to TR:CAB94639 (EMBL:AL359215) Streptomyces coelicolor FecCD-family membrane transport protein SC2H12.15%2C 368 aa%3B fasta scores: opt: 942 z-score: 839.0 E(): 0%3B 45.8%25 identity in 360 aa overlap. Contains Pfam match to entry PF01032 FecCD_family%2C FecCD transport family. Also contains possible hydrophobic membrane spanning regions gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0997 SCO0998 SCO0998 2SCG2.11 2SCG2.11 1053765 1054583 + Fe uptake system permease 2SCG2.11%2C ftrE%2C Fe uptake system permease%2C len: 272 aa%3B similar to previously sequenced and annotated as TR:Q9X470 (EMBL:AF099015) Streptomyces coelicolor Fe uptake system permease FtrE%2C 271 aa%3B fasta scores:opt: 1424 z-score: 1545.2 E(): 0%3B 89.5%25 identity in 257 aa overlap and similar to TR:CAB94640 (EMBL:AL359215) Streptomyces coelicolor iron transport protein%2C ATP-binding component SC2H12.16%2C 258 aa%3B fasta scores: opt: 834 z-score: 672.9 E(): 7.8e-32%3B 55.4%25 identity in 251 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0998 SCO0999 SCO0999 2SCG2.12c 2SCG2.12c 1054754 1055401 - superoxide dismutase 2SCG2.12c%2C sodF2%2C superoxide dismutase%2C len: 215 aa%3B previously sequenced as TR:Q9X469 (EMBL:AF099015) Streptomyces coelicolor superoxide dismutase (EC 1.15.1.1) SodF2%2C 215 aa and similar to SW:SODF_STRCO (EMBL:AF012087) Streptomyces coelicolor superoxide dismutase SodF%2C (SC8E4A.03) 213 aa%3B fasta scores: opt: 1315 z-score: 1473.9 E(): 0%3B 89.3%25 identity in 215 aa overlap. Contains Pfam match to entry PF00081 sodfe%2C Iron/manganese superoxide dismutases (SODM) and match to Prosite entry PS00088 Manganese and iron superoxide dismutases signature gene gene985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO0999 SCO1000 SCO1000 2SCG2.13c 2SCG2.13c 1055883 1056995 - integrase 2SCG2.13c%2C integrase%2C len: 370 aa%3B N-terminal previously sequenced and annotated as TR:Q9X468 (EMBL:AF099015) Streptomyces coelicolor integrase Int%2C 222 aa. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family gene gene986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1000 SCO1001 SCO1001 2SCG2.14 2SCG2.14 1057387 1057749 + hypothetical protein 2SCG2.14%2C unknown%2C len: 120 aa gene gene987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1001 SCO1002 SCO1002 2SCG2.15c 2SCG2.15c 1057892 1058278 - hypothetical protein 2SCG2.15c%2C unknown%2C len: 128 aa gene gene988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1002 SCO1003 SCO1003 2SCG2.16 2SCG2.16 1058377 1058961 + TetR family transcriptional regulator 2SCG2.16%2C probable tetR-family transcriptional regulator%2C len: 194 aa%3B similar to TR:Q9RL21 (EMBL:AL117385) Streptomyces coelicolor transcriptional regulator SC5G9.05%2C 193 aa%3B fasta scores: opt: 408 z-score: 498.8 E(): 2.9e-20%3B 39.4%25 identity in 193 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains possible helix-turn-helix motif at residues 37..58 (+4.68 SD) gene gene989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1003 SCO1004 SCO1004 2SCG2.17c 2SCG2.17c 1059073 1059873 - hypothetical protein 2SCG2.17c%2C unknown%2C len: 266 aa%3B similar to part of TR:CAC01640 (EMBL:AL391072) Streptomyces coelicolor conserved hypothetical protein SC9A4.13%2C 267 aa%3B fasta scores opt: 191 z-score: 213.7 E(): 0.00022%3B 52.5%25 identity in 59 aa overlap. Contains a TTA leucine codon%2C possible target for bldA regulation gene gene990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1004 SCO1005 SCO1005 2SCG2.18 2SCG2.18 1060181 1061398 + insertion element 2SCG2.18%2C IS110-B%2C insertion element%2C len: 405 aa%3B identical to previously sequenced SW:YIS1_STRCO (EMBL:Y00434) Streptomyces coelicolor insertion element IS110 hypothetical 43.6 kDa protein SC3C8.10%2C 405 aa. Contains Pfam match to entry PF01548 Transposase_9%2C Transposase and PF02371 Transposase_19%2C Transposase gene gene991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1005 SCO1006 SCO1006 2SCG2.19c 2SCG2.19c 1061415 1061552 - hypothetical protein 2SCG2.19c%2C hypothetical protein%2C len: 45 aa%3B similar to part of TR:CAC01640 (EMBL:AL391072) Streptomyces coelicolor conserved hypothetical protein SC9A4.13%2C 267 aa%3B fasta scores: opt: 140 z-score: 206.9 E(): 0.00053%3B 72.4%25 identity in 29 aa overlap gene gene992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1006 SCO1007 SCO1007 2SCG2.20c 2SCG2.20c 1061871 1063013 - oxidoreductase 2SCG2.20c%2C possible oxidoreductase%2C len: 380 aa%3B similar to TR:O54177 (EMBL:AL021411) Streptomyces coelicolor oxidoreductase SC7H1.18%2C 397 aa%3B fasta scores: opt: 842 z-score: 944.5 E(): 0%3B 41.6%25 identity in 368 aa overlap. Contains Pfam matches to entries PF01494 FAD_binding_3%2C FAD binding domain and PF01360 Monooxygenase%2C Monooxygenase gene gene993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1007 SCO1008 SCO1008 2SCG2.21 2SCG2.21 1063185 1063520 + hypothetical protein 2SCG2.21%2C hypothetical protein%2C len: 111 aa%3B similar to the plasmid SCP1 protein TR:Q52517 (EMBL:M18263) Streptomyces coelicolor hypothetical 12.1 kDa protein MmyJ%2C 111 aa%3B fasta scores: opt: 246 z-score: 332.3 E(): 5.5e-11%3B 43.8%25 identity in 89 aa overlap gene gene994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1008 SCO1009 SCO1009 2SCG2.22c 2SCG2.22c 1063535 1064155 - transposase 2SCG2.22c%2C possible transposase%2C len: 206 aa%3B N-terminal region similar to N-terminal region of TR:Q9XAG8 (EMBL:AL079356) Streptomyces coelicolor transposase SC6G9.06c%2C 247 aa%3B fasta scores: opt: 628 z-score: 727.1 E(): 0%3B 73.7%25 identity in 133 aa overlap gene gene995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1009 SCO1010 SCO1010 2SCG2.23 2SCG2.23 1064858 1066294 + integral membrane transport protein 2SCG2.23%2C possible integral membrane transport protein%2C len: 478 aa%3B highly similar to TR:O68895 (EMBL:AF056309) Streptomyces argillaceus membrane protein ORFA%2C 414 aa%3B fasta scores: opt: 1923 z-score: 2121.0 E(): 0%3B 82.0%25 identity in 362 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and match to Prosite entry PS00217 Sugar transport proteins signature 2. Also contains possible hydrophobic membrane spanning regions gene gene996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1010 SCO1011 SCO1011 2SCG2.24c 2SCG2.24c 1066337 1068241 - hypothetical protein 2SCG2.24c%2C hypothetical protein%2C len: 634 aa%3B similar to TR:Q00509 (EMBL:X6451) Streptomyces ambofaciens hypothetical SrmR protein%2C 604 aa%3B fasta scores: opt: 952 z-score: 1028.3 E(): 0%3B 36.5%25 identity in 600 aa overlap. Contains Pfam match to entry PF01590 GAF%2C GAF domain gene gene997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1011 SCO1012 SCO1012 2SCG2.25c 2SCG2.25c 1068298 1069098 - oxidoreductase 2SCG2.25c%2C probable oxidoreductase%2C len: 266 aa%3B similar to SW:BDHA_ALCEU (EMBL:AF145230) Alcaligenes eutrophus D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30) HbdH1%2C 258 aa%3B fasta scores: opt: 586 z-score: 655.1 E(): 5.8e-29%3B 39.3%25 identity in 257 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1012 SCO1013 SCO1013 2SCG2.26c 2SCG2.26c 1069154 1069633 - mut-like protein 2SCG2.26c%2C possible mut-like protein%2C len: 159 aa%3B similar to TR:Q9K3X1 (EMBL:AL359988) Streptomyces coelicolor mut-like protein SCD10.05c%2C 184 aa%3B fasta scores: opt: 203 z-score: 264.6 E(): 3.2e-07%3B 35.7%25 identity in 126 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and match to Prosite entry PS00893 mutT domain signature gene gene999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1013 SCO1014 SCO1014 2SCG2.28c 2SCG2.28c 1069702 1071315 - transferase 2SCG2.28c%2C probable transferase%2C len: 537 aa%3B similar to SW:LNT_ECOLI (EMBL:X58070) Escherichia coli apolipoprotein N-acyltransferase (EC 2.3.1.-) CutE%2C 512 aa%3B fasta scores: opt: 328 z-score: 352.1 E(): 4.4e-12%3B 26.1%25 identity in 533 aa overlap. Contains Pfam match to entry PF00795 CN_hydrolase%2C Carbon-nitrogen hydrolase. Also contains possible hydrophobic membrane spanning regions gene gene1000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1014 SCO1015 SCO1015 2SCG2.29c 2SCG2.29c 1071312 1071656 - hypothetical protein 2SCG2.29c%2C unknown%2C len: 114 aa gene gene1001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1015 SCO1016 SCO1016 2SCG2.30c 2SCG2.30c 1071720 1072544 - hypothetical protein 2SCG2.30c%2C possible hypothetical protein%2C len: 274 aa. Contains possible N-terminal region signal peptide sequence. Rich in alanine and proline amino acid residues. High content in G+C (79.8%25) gene gene1002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1016 SCO1017 SCO1017 2SCG2.31c 2SCG2.31c 1072677 1073219 - lipoprotein 2SCG2.31c%2C possible lipoprotein%2C len: 180 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains at N-terminal region possible hydrophobic membrane spanning regions gene gene1003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1017 SCO1018 SCO1018 2SCG2.32c 2SCG2.32c 1073299 1074141 - glutamate racemase 2SCG2.32c%2C glutamate racemase%2C len: 280 aa%3B similar to SW:MURI_ECOLI (EMBL:) Escherichia coli glutamate racemase (EC 5.1.1.3) MurI%2C 285 aa%3B fasta scores: opt: 359 z-score: 390.2 E(): 3.3e-14%3B 34.4%25 identity in 256 aa overlap. Contains Pfam match to entry PF01177 Asp_Glu_race%2C Aspartate / glutamate racemase and match to Prosite entry PS00923 Aspartate and glutamate racemases signature 1 gene gene1004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1018 SCO1019 SCO1019 2SCG2.33 2SCG2.33 1074142 1075377 + hypothetical protein 2SCG2.33%2C possible integral membrane protein%2C len: 411 aa%3B similar to TR:P74597 (EMBL:D90916) Synechocystis sp. hypothetical 43.6 kDa protein SLR1566%2C 395 aa%3B fasta scores: opt: 1119 z-score: 1282.3 E(): 0%3B 46.3%25 identity in 402 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferase and a cleavable N-terminal signal sequence gene gene1005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1019 SCO1020 SCO1020 2SCG2.34c 2SCG2.34c 1075397 1076719 - hypothetical protein 2SCG2.34c%2C conserved hypothetical protein%2C len: 440 aa%3B similar to the plasmid encoded SW:TERA_ALCSP (EMBL:M20238) Alcaligenes sp. tellurium resistance protein TerA%2C 339 aa%3B fasta scores: opt: 515 z-score: 412.2 E(): 1.9e-15%3B 35.1%25 identity in 396 aa overlap. Contains Pfam match to entry PF02342 TerD gene gene1006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1020 SCO1021 SCO1021 2SCG2.35 2SCG2.35 1077009 1077458 + hypothetical protein SCG20A.01%2C unknown (fragment)%2C len: >110 aa~2SCG2.35%2C unknown (fragment)%2C len: >72 aa gene gene1007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1021 SCO1022 SCO1022 SCG20A.02 SCG20A.02 1077501 1078328 + hypothetical protein SCG20A.02%2C hypothetical protein%2C len: 275 aa%3B similar to C-terminal part of TR:Q9XFN9 (EMBL:AC000107) Arabidopsis thaliana F17F8.6%2C 325 aa%3B fasta scores: opt: 491 z-score: 580.3 E(): 7.6e-25%3B 34.1%25 identity in 305 aa overlap and to TR:Q9HZI4 (EMBL:AE004727) Pseudomonas aeruginosa hypothetical protein PA3022%2C 268 aa%3B fasta scores: opt: 688 Z-score: 795.9 E(): 1.1e-36%3B 45.788%25 identity in 273 aa overlap gene gene1008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1022 SCO1023 SCO1023 SCG20A.03 SCG20A.03 1078574 1079182 + hypothetical protein SCG20A.03%2C possible membrane protein%2C len: 202 aa%3B similar to TR:Q9RIY8 (EMBL:AL109962) Streptomyces coelicolor hypothetical 20.8 kD protein%2C SCJ1.26%2C 193 aa%3B fasta scores: opt: 201 z-score: 245.7 E(): 3.3e-06%3B 35.4%25 identity in 195 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1009 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1023 SCO1024 SCO1024 SCG20A.04 SCG20A.04 1079228 1081729 + hypothetical protein SCG20A.04%2C hypothetical protein%2C len: 833 aa%3B highly similar in its C-terminal domain to SW:SP5K_BACSU (EMBL:X59412) Bacillus subtilis stage V sporulation protein K SpoVK%2C 322 aa%3B fasta scores: opt: 699 z-score: 720.9 E(): 1.1e-32%3B 42.6%25 identity in 265 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1024 SCO1025 SCO1025 SCG20A.05c SCG20A.05c 1081780 1084137 - hypothetical protein SCG20A.05c%2C possible integral membrane protein%2C len: 785 aa. Contains possible hydrophobic membrane spanning regions. High content in alanine and leucine amino acid residues gene gene1011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1025 SCO1026 SCO1026 SCG20A.06 SCG20A.06 1084395 1085219 + transcriptional regulator SCG20A.06%2C probable transcriptional regulatory protein%2C len: 274 aa%3B similar to SW:AGAR_ECOLI (EMBL:U18997) Escherichia coli aga operon transcriptional repressor AgaR%2C 269 aa%3B fasta scores: opt: 524 z-score: 597.5 E(): 8.4e-26%3B 36.6%25 identity in 246 aa overlap. Contains Pfam match to entry PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family and match to Prosite entry PS00894 Bacterial regulatory proteins%2C deoR family signature. Contains also possible helix-turn-helix motif at residues 26..47 (+2.94 SD) gene gene1012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1026 SCO1027 SCO1027 SCG20A.07 SCG20A.07 1085351 1085824 + hypothetical protein SCG20A.07%2C hypothetical protein%2C len: 157 aa%3B similar to SW:Y0BR_MYCTU (EMBL:Z77724) Mycobacterium tuberculosis hypothetical 19.0 kD protein CY227.27c%2C 167 aa%3B fasta scores: opt: 218 z-score: 283.7 E(): 2.5e-08%3B 30.7%25 identity in 150 aa overlap gene gene1013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1027 SCO1028 SCO1028 SCG20A.08c SCG20A.08c 1085859 1086983 - lyase SCG20A.08c%2C possible lyase%2C len: 374 aa%3B highly similar to TR:O69652 (EMBL:AL022121) Mycobacterium tuberculosis lyase MTV025.032%2C 346 aa%3B fasta scores: opt: 1469 z-score: 1762.4 E(): 0%3B 63.3%25 identity in 341 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase%2C Pyridoxal-phosphate dependent enzyme gene gene1014 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1028 SCO1029 SCO1029 SCG20A.09 SCG20A.09 1087360 1087587 + hypothetical protein SCG20A.09%2C unknown%2C len: 75 aa gene gene1015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1029 SCO1030 SCO1030 SCG20A.10 SCG20A.10 1087803 1088321 + hypothetical protein SCG20A.10%2C conserved hypothetical protein%2C len: 172 aa%3B similar to TR:CAB88805 (EMBL:AL35383) Streptomyces coelicolor hypothetical 20.2 kD protein (fragment) SCE6.01c%2C 183 aa%3B fasta scores: opt: 227 z-score: 278.3 E(): 5e-08%3B 36.6%25 identity in 134 aa overlap gene gene1016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1030 SCO1031 SCO1031 SCG20A.11c SCG20A.11c 1088547 1091114 - ABC transporter SCG20A.11c%2C possible ABC transport system integral membrane protein%2C len: 855 aa%3B similar to TR:CAB89462 (EMBL:AL354048) Streptomyces coelicolor ABC transporter integral membrane protein SCE25.31%2C 843 aa%3B fasta scores: opt: 1459 z-score: 1443.9 E(): 0%3B 34.7%25 identity in 864 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1031 SCO1032 SCO1032 SCG20A.12c SCG20A.12c 1091111 1091860 - ABC transporter ATP-binding protein SCG20A.12c%2C probable ABC transport system ATP-binding protein%2C len: 249 aa%3B similar to many%2C e.g. TR:CAB89461 (EMBL:AL354048) Streptomyces coelicolor ABC transport system ATP-binding protein SCE25.31%2C 256 aa%3B fasta scores: opt: 1112 z-score: 953.1 E(): 0%3B 67.9%25 identity in 240 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene1018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1032 SCO1033 SCO1033 SCG20A.13c SCG20A.13c 1091857 1092141 - hypothetical protein SCG20A.13c%2C possible membrane protein%2C len: 94 aa%3B low similarity to TR:Q9WYF1 (EMBL:AE001713) Thermotoga maritima hypothetical 10.3 kD protein TM0315%2C 83 aa%3B fasta scores: opt: 95 z-score: 135.8 E(): 4.4%3B 29.7%25 identity in 74 aa overlap. Contains possible hydrophobic membrane spanning region gene gene1019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1033 SCO1034 SCO1034 SCG20A.14 SCG20A.14 1092244 1092897 + TetR family transcriptional regulator SCG20A.14%2C possible tetR-family regulatory protein%2C len: 217 aa%3B similar to TR:Q9RJ10 (EMBL:AL109962) Streptomyces coelicolor transcriptional regulatory protein SCJ1.04%2C 207 aa%3B fasta scores: opt: 208 z-score: 253.6 E(): 1.2e-06%3B 27.2%25 identity in 195 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene1020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1034 SCO1035 SCO1035 SCG20A.15 SCG20A.15 1092908 1093495 + hypothetical protein SCG20A.15%2C unknown%2C len: 195 aa gene gene1021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1035 SCO1036 SCO1036 SCG20A.16 SCG20A.16 1093492 1094400 + phosphotriesterase-family protein SCG20A.16%2C probable phosphotriesterase-family protein%2C len: 302 aa%3B similar to SW:PHP_ECOLI (EMBL:U18997) Escherichia coli phosphotriesterase homology protein Php%2C 292 aa%3B fasta scores: opt: 319 z-score: 370.9 E(): 3.5e-13%3B 28.0%25 identity in 286 aa overlap. Contains Pfam match to entry PF02126 PTE%2C Phosphotriesterase family and match to Prosite entry PS01323 Phosphotriesterase family signature 2 gene gene1022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1036 SCO1037 SCO1037 SCG20A.17 SCG20A.17 1094465 1094866 + hypothetical protein SCG20A.17%2C hypothetical protein%2C len: 133 aa%3B similar to TR:O32183 (EMBL:Z99120) Bacillus subtilis hypothetical protein YusQ%2C 127 aa%3B fasta scores: opt: 280 z-score: 359.2 E(): 1.6e-12%3B 36.4%25 identity in 129 aa overlap gene gene1023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1037 SCO1038 SCO1038 SCG20A.18 SCG20A.18 1094911 1095258 + hypothetical protein SCG20A.18%2C hypothetical protein%2C len: 115 aa%3B similar to TR:O06633 (EMBL:Z95618) Mycobacterium tuberculosis hypothetical 12.5 kD protein aa%3B fasta scores: opt: 138 z-score: 194.2 E(): 0.0024%3B 34.0%25 identity in 97 aa overlap gene gene1024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1038 SCO1039 SCO1039 SCG20A.19c SCG20A.19c 1095280 1096518 - regulatory protein SCG20A.19c%2C possible ROK family regulatory protein%2C len: 412 aa%3B similar to TR:O50502 (EMBL:AL009199) Streptomyces coelicolor probable transcriptional repressor protein SC7B7.05%2C 403 aa%3B fasta scores: opt: 456 z-score: 485.8 E(): 1.4e-19%3B 27.7%25 identity in 390 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family gene gene1025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1039 SCO1040 SCO1040 SCG20A.20c SCG20A.20c 1096556 1097206 - DNA repair protein SCG20A.20c%2C probable DNA repair protein%2C len: 216 aa%3B similar to SW:ALKB_ECOLI (EMBL:J02607) Escherichia coli DNA repair protein AlkB%2C 216 aa%3B fasta scores: opt: 302 z-score: 361.8 E(): 1.1e-12%3B 34.3%25 identity in 207 aa overlap gene gene1026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1040 SCO1041 SCO1041 SCG20A.21 SCG20A.21 1097282 1098505 + hypothetical protein SCG20A.21%2C hypothetical protein%2C len: 407 aa%3B similar to SW:YGJO_ECOLI (EMBL:U18997) Escherichia coli hypothetical 43.4 kD protein in EbgC-UxaA intergenic region Ygjo%2C 388 aa%3B fasta scores: opt: 956 z-score: 1103.1 E(): 0%3B 44.0%25 identity in 373 aa overlap gene gene1027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1041 SCO1042 SCO1042 SCG20A.22c SCG20A.22c 1098616 1098966 - hypothetical protein SCG20A.22c%2C hypothetical protein%2C len: 116 aa%3B similar to N-terminal part of TR:Q9UYH1 (EMBL:AJ248287) Pyrococcus abyssi glutamine-fructose-6-phosphate transaminase related%2C 341 aa%3B fasta scores: opt: 135 z-score: 173.1 E(): 0.036%3B 33.0%25 identity in 103 aa overlap gene gene1028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1042 SCO1043 SCO1043 SCG20A.23 SCG20A.23 1099030 1099809 + transcriptional regulator SCG20A.23%2C probable transcriptional regulatory protein%2C len: 259 aa%3B similar to SW:SRLR_ECOLI (EMBL:J02708) Escherichia coli glucitol operon repressor SrlR%2C 257 aa%3B fasta scores: opt: 429 z-score: 487.9 E(): 1.1e-19%3B 30.6%25 identity in 258 aa overlap. Contains Pfam match to entry PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family and match to Prosite entry PS00894 Bacterial regulatory proteins%2C deoR family signature. Contains also a possible helix-turn-helix motif at residues 20..41 (+2.55 SD) gene gene1029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1043 SCO1044 SCO1044 SCG20A.24c SCG20A.24c 1099831 1100772 - hypothetical protein SCG20A.24c%2C possible hypothetical protein%2C len: 313 aa. Contains possible N-terminal region signal peptide sequence gene gene1030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1044 SCO1045 SCO1045 SCG20A.25 SCG20A.25 1100965 1101198 + metal associated protein SCG20A.25%2C possible metal associated protein%2C len: 77 aa%3B similar to SW:COPP_HELFE (EMBL:AJ001932) Helicobacter felis cop associated protein (copper ion binding protein) CopP%2C 66 aa%3B fasta scores: opt: 153 z-score: 210.7 E(): 0.00029%3B 40.7%25 identity in 59 aa overlap and to TR:Q9RDJ5 (EMBL:AL136519) Streptomyces coelicolor regulator (fragment) SCC57A.01%2C >47 aa%3B fasta scores: opt: 146 z-score: 186.0 E(): 9.3e-05%3B 53.2%25 identity in 47 aa overlap. Contains Pfam match to entry PF00403 HMA%2C Heavy-metal-associated domain gene gene1031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1045 SCO1046 SCO1046 SCG20A.26 SCG20A.26 1101284 1103545 + metal transporter ATPase SCG20A.26%2C probable metal transporter ATPase%2C len: 753 aa%3B similar to SW:ATCU_RHIME (EMBL:AF129004) Rhizobium meliloti copper-transporting ATPase (EC 3.6.1.36) ActP%2C 827 aa%3B fasta scores: opt: 1748 z-score: 1773.4 E(): 0%3B 42.4%25 identity in 767 aa overlap and to TR:Q9RDJ4 (EMBL:AL136519) Streptomyces coelicolor cation-transporting P-type ATPase SCC57A.02%2C 760 aa%3B fasta scores: opt: 3484 z-score: 2834.6 E(): 0%3B 73.9%25 identity in 761 aa overlap. Contains Pfam matches to entries PF00403 HMA%2C Heavy-metal-associated domain and PF00122 E1-E2_ATPase%2C E1-E2 ATPase and matches to Prosite entries PS01047 Heavy-metal-associated domain%2C PS00154 E1-E2 ATPases phosphorylation site and PS01229 Hypothetical cof family signature 2. Contains also possible hydrophobic membrane spanning regions gene gene1032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1046 SCO1047 SCO1047 SCG20A.27 SCG20A.27 1103835 1104527 + hypothetical protein SCG20A.27%2C possible integral membrane protein%2C len: 230 aa%3B similar to TR:O86625 (EMBL:AL031155) Streptomyces coelicolor integral membrane protein SC3A7.24c%2C 201 aa%3B fasta scores: opt: 277 z-score: 278.6 E(): 4.9e-08%3B 41.7%25 identity in 168 aa overlap. Contains Pfam match to entry PF01569 PAP2%2C PAP2 superfamily and possible hydrophobic membrane spanning regions gene gene1033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1047 SCO1048 SCO1048 SCG20A.28c SCG20A.28c 1104500 1104952 - hypothetical protein SCG20A.28c%2C possible hypothetical protein%2C len: 150 aa%3B similar to TR:Q9Z4W (EMBL:AL035654) Streptomyces coelicolor hypothetical 16.4 kD protein SCE8.15c%2C 151 aa%3B fasta scores: opt: 727 z-score: 866.9 E(): 0%3B 72.1%25 identity in 147 aa overlap gene gene1034 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1048 SCO1049 SCO1049 SCG20A.29c SCG20A.29c 1105031 1106194 - oxidoreductase SCG20A.29c%2C probable oxidoreductase%2C len: 387 aa%3B similar to SW:GFO_ZYMMO (EMBL:M97379) Zymomonas mobilis glucose-fructose oxidoreductase precursor (EC 1.1.99.28) Gfo%2C 439 aa%3B fasta scores: opt: 287 z-score: 318.4 E(): 2.9e-10%3B 26.6%25 identity in 350 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family and possible N-terminal region signal peptide sequence gene gene1035 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1049 SCO1050 SCO1050 SCG20A.30 SCG20A.30 1106404 1107006 + DNA protection protein SCG20A.30%2C possible DNA protection protein%2C len: 200 aa%3B similar to SW:DPS_ECOLI (EMBL:X69337) Escherichia coli DNA protection during starvation protein Dps%2C 166 aa%3B fasta scores: opt: 200 z-score: 257.4 E(): 7.4e-07%3B 27.5%25 identity in 138 aa overlap. Contains Pfam match to entry PF02047 DPS%2C Dps protein family and matches to Prosite entries PS00818 Dps protein family signature 1 and PS00819 Dps protein family signature 2 gene gene1036 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1050 SCO1051 SCO1051 SCG20A.31 SCG20A.31 1107018 1108091 + hypothetical protein SCG20A.31%2C possible integral membrane protein%2C len: 357 aa%3B similar to TR:Q9S290 (EMBL:AL096849) Streptomyces coelicolor membrane protein SCI11.29%2C 354 aa%3B fasta scores: opt: 422 z-score: 473.8 E(): 6.5e-19%3B 30.5%25 identity in 357 aa overlap gene gene1037 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1051 SCO1052 SCO1052 SCG20A.32c SCG20A.32c 1108110 1108778 - regulatory protein SCG20A.32c%2C possible regulatory protein%2C len: 222 aa%3B similar to C-terminal part of TR:CAB91114 (EMBL:AL355913) Streptomyces coelicolor regulatory protein SC5H4.02%2C 552 aa%3B fasta scores: opt: 195 z-score: 192.1 E(): 0.0032%3B 30.5%25 identity in 210 aa overlap. Contains possible helix-turn-helix motif at residues 172..193 (+3.29 SD) gene gene1038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1052 SCO1053 SCO1053 SCG20A.33c SCG20A.33c 1109004 1109432 - hypothetical protein SCG20A.33c%2C unknown%2C len: 142. Doubtful CDS gene gene1039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1053 SCO1054 SCO1054 SCG20A.34 SCG20A.34 1109450 1110652 + aminotransferase SCG20A.34%2C possible aminotransferase%2C len: 400 aa%3B similar to TR:Q9XAD5 (EMBL:AL096839) Streptomyces coelicolor aminotransferase SCC22.03c%2C 418 aa%3B fasta scores: opt: 397 z-score: 446.1 E(): 2.3e-17%3B 27.7%25 identity in 423 aa overlap and to TR:Q9RY03 (EMBL:AE001877) Deinococcus radiodurans NifS-related protein DR0151%2C 401 aa%3B fasta scores: opt: 791 z-score: 884.2 E(): 0%3B 41.2%25 identity in 396 aa overlap. Contains Pfam match to entry PF00266 aminotran_5%2C Aminotransferases class-V gene gene1040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1054 SCO1055 SCO1055 SCG20A.35c SCG20A.35c 1110755 1113025 - alpha-xylosidase catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose%2C glucose%2C mannose%2C fructose%2C maltose%2C isomaltose%2C nigerose%2C kojibiose%2C sucrose%2C and trehalose%3B shows higher activity against alpha-xylosyl fluoride%2C isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose)%2C and alpha-xyloside in xyloglucan oligosaccharides gene gene1041 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1055 SCO1056 SCO1056 SCG22.02 SCG22.02 1113337 1114596 + sugar transport sugar binding protein SCG22.02%2C possible sugar transport sugar binding protein%2C len: 419 aa%3B similar to TR:CAB90879 (EMBL:AL355752) Streptomyces coelicolor maltose-binding protein MalE%2C 423 aa%3B fasta scores: opt: 433 z-score: 507.0 E(): 9.2e-21%3B 28.7%25 identity in 380 aa overlap and to SW:MALX_STRPN (EMBL:L08611) Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX%2C 423 aa%3B fasta scores: opt: 255 z-score: 299.6 E(): 3.3e-09%3B 23.9%25 identity in 372 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also a possible N-terminal signal peptide sequence gene gene1042 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1056 SCO1057 SCO1057 SCG22.03 SCG22.03 1114608 1115573 + sugar transport integral membrane protein SCG22.03%2C possible sugar transport integral membrane protein%2C len: 321 aa%3B similar to TR:Q9RK91 (EMBL:AL117322) Streptomyces coelicolor binding-protein-dependent transport protein SCF1.13%2C 317 aa%3B fasta scores: opt: 681 z-score: 798.6 E(): 0%3B 35.0%25 identity in 317 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene1043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1057 SCO1058 SCO1058 SCG22.04 SCG22.04 1115579 1116406 + sugar transport integral membrane protein SCG22.04%2C possible sugar transport integral membrane protein%2C len: 275 aa%3B similar to TR:Q9RUF0 (EMBL:AE001988) Deinococcus radiodurans ABC transporter%2C permease%2C MalFG family%2C DR1436 aa%3B fasta scores: opt: 550 z-score: 629.9 E(): 1.3e-27%3B 32.9%25 identity in 283 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene1044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1058 SCO1059 SCO1059 SCG22.05 SCG22.05 1116447 1117826 + beta-glucosidase SCG22.05%2C probable beta-glucosidase%2C len: 459 aa%3B similar to TR:Q59976 (EMBL:Z29625) Streptomyces sp. beta-glucosidase (EC 3.2.1.21) Bgl3%2C 479 aa%3B fasta scores: opt: 1627 z-score: 1895.8 E(): 0%3B 57.6%25 identity in 458 aa overlap. Contains Pfam match to entry PF00232 Glyco_hydro_1%2C Glycosyl hydrolase family 1 and match to Prosite entry PS00653 Glycosyl hydrolases family 1 N-terminal signature gene gene1045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1059 SCO1060 SCO1060 SCG22.06c SCG22.06c 1117870 1119111 - transcriptional repressor SCG22.06%2C probable transcriptional repressor%2C len: 413 aa%3B similar to TR:O05180 (EMBL:Z71474) Bacillus megaterium Xyl repressor XylR%2C 388 aa%3B fasta scores: opt: 382 z-score: 417.8 E(): 8.5e-16%3B 31.3%25 identity in 386 aa overlap and to TR:CAB61583 (EMBL:AL133210) Streptomyces coelicolor possible xylose repressor SCF37.02%2C 402 aa%3B fasta scores: opt: 586 z-score: 523.0 E(): 1.5e-23%3B 48.0%25 identity in 396 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and a possible helix-turn-helix motif at residues 35..56 (+3.03 SD) gene gene1046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1060 SCO1061 SCO1061 SCG22.07c SCG22.07c 1119167 1120834 - bifunctional sugar binding protein/sugar hydrolase SCG22.07%2C probable bifunctional protein ( sugar binding protein/sugar hydrolase)%2C len: 555 aa%3B N-terminal domain similar to N-terminal domain of TR:O86727 (EMBL:AL031515) Streptomyces coelicolor cellulase SC5C7.30c%2C 890 aa%3B blastp scores: Score %3D 84 (29.6 bits)%2C Expect %3D 0.031%2C Sum P(3) %3D 0.030 Identities %3D 61/233 (26%25)%2C Positives %3D 89/233 (38%25) and C-terminal domain similar to C-terminal domain of SW:E13B_OERXA (EMBL:AF052745) Oerskovia xanthineolytica glucan enco-1%2C3-glucosidase precursor (EC 3.2.1.39)%2C 548 aa%3B fasta scores: opt: 368 Z-score: 394.8 E(): 2.3e-14%3B 41.447%25 identity) in 152 aa overlap. Contains 3x Pfam match to entry PF02012 BNR%2C BNR repeat and Pfam match to entry PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain%2C 3 copies. Contains also possible N-terminal region signal peptide sequence gene gene1047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1061 SCO1062 SCO1062 SCG22.08c SCG22.08c 1120925 1123006 - hydrolase SCG22.08c%2C possible hydrolase%2C len: 693 aa%3B similar to SW:BGLR_ECOLI (EMBL:M14641) Escherichia coli beta-glucuronidase (EC 3.2.1.31) GusA%2C 603 aa%3B fasta scores: opt: 386 z-score: 439.2 E(): 5.5e-17%3B 25.3%25 identity in 582 aa overlap and to TR:Q9RIU6 (EMBL: AL133278) Streptomyces coelicolor hydrolase SCM11.15c%2C 872 aa%3B fasta scores: opt: 977 z-score: 1111.4 E(): 0%3B 37.1%25 identity in 596 aa overlap gene gene1048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1062 SCO1063 SCO1063 SCG22.09c SCG22.09c 1123067 1123960 - sugar transport integral membrane protein SCG22.09c%2C possible sugar transport integral membrane protein%2C len: 297 aa%3B similar to SW:LACG_AGRRD (EMBL:X66596) Agrobacterium radiobacter lactose transport system permease LacG%2C 273 aa%3B fasta scores: opt: 514 z-score: 627.5 E(): 1.8e-27%3B 35.1%25 identity in 282 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains also possible hydrophobic membrane spanning regions gene gene1049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1063 SCO1064 SCO1064 SCG22.10c SCG22.10c 1123963 1124898 - sugar transport integral membrane protein SCG22.10c%2C probable sugar transport integral membrane protein%2C len: 311 aa%3B similar to TR:AAF37728 (EMBL:AF086819) Thermomonospora fusca cellobiose transport permease BglA%2C 302 aa%3B fasta scores: opt: 664 z-score: 802.8 E(): 0%3B 38.6%25 identity in 280 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene1050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1064 SCO1065 SCO1065 SCG22.11c SCG22.11c 1124895 1126256 - sugar transport sugar binding protein SCG22.11c%2C possible sugar transport sugar binding protein%2C len: 453 aa%3B similar to SW:LACE_AGRRD (EMBL:X66596) Agrobacterium radiobacter lactose-binding protein precursor LacE%2C 422 aa%3B fasta scores: opt: 273 z-score: 296.9 E(): 4.6e-09%3B 23.8%25 identity in 420 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and possible N-terminal region signal peptide sequence gene gene1051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1065 SCO1066 SCO1066 SCG22.12 SCG22.12 1126535 1127557 + LacI family transcriptional regulator SCG22.12%2C probable lacI-family transcriptional regulator%2C len: 340 aa%3B similar to SW:CYTR_ECOLI (EMBL:X03683) Escherichia coli transcriptional repressor CytR%2C 341 aa%3B fasta scores: opt: 608 z-score: 692.2 E(): 4.4e-31%3B 34.2%25 identity in 339 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature and possible helix-turn-helix motif at residues 4..25 (+6.04 SD) gene gene1052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1066 SCO1067 SCO1067 SCG22.13 SCG22.13 1127704 1128876 + integral membrane transport protein SCG22.13%2C possible integral membrane transport protein%2C len: 390 aa%3B similar to TR:Q9RRI8 (EMBL:AE002079) Deinococcus radiodurans transport protein%2C DR2502%2C 471 aa%3B fasta scores: opt: 774 z-score: 797.8 E(): 0%3B 40.3%25 identity in 387 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1067 SCO1068 SCO1068 SCG22.14 SCG22.14 1128954 1129694 + hypothetical protein SCG22.14%2C conserved hypothetical protein%2C len: 246 aa%3B similar to TR:CAB92209 (EMBL:AL356592) Streptomyces coelicolor hypothetical 27.6 kD protein SC9H11.20%2C 255 aa%3B fasta scores: opt: 369 z-score: 455.9 E(): 6.4e-18%3B 37.0%25 identity in 257 aa overlap gene gene1054 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1068 SCO1069 SCO1069 SCG22.15c SCG22.15c 1129716 1130195 - MarR family transcriptional regulator SCG22.15c%2C possible marR-family transcriptional regulator%2C len: 159 aa%3B similar to TR:Q9X8V0 (EMBL:AL049826) Streptomyces coelicolor transcriptional regulator SCH24.36c%2C 154 aa%3B fasta scores: opt: 302 z-score: 391.5 E(): 2.5e-14%3B 41.4%25 identity in 128 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and match to Prosite entry PS01117 Bacterial regulatory proteins%2C marR family signature. Contains also a possible helix-turn-helix motif at residues 89..110 (+4.56 SD) gene gene1055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1069 SCO1070 SCO1070 SCG22.16c SCG22.16c 1130429 1131094 - two component system response regulator SCG22.16c%2C possible two component system response regulator%2C len: 221 aa%3B similar to TR:O69816 (EMBL:AL023496) Streptomyces coelicolor two component regulator SC1A6.11%2C 224 aa%3B fasta scores: opt: 872 z-score: 1006.3 E(): 0%3B 64.8%25 identity in 216 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Contains also a possible helix-turn-helix motif at residues 170..191 (+2.64 SD) gene gene1056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1070 SCO1071 SCO1071 SCG22.17c SCG22.17c 1131091 1132338 - two component system sensor kinase SCG22.17c%2C possible two component system sensor kinase%2C len: 415 aa%3B similar to TR:Q9X8S1 (EMBL:AL049754) Streptomyces coelicolor two component system sensor kinase SCH10.32c%2C 441 aa%3B fasta scores: opt: 723 z-score: 761.0 E(): 0%3B 40.6%25 identity in 382 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1071 SCO1072 SCO1072 SCG22.18 SCG22.18 1132462 1132683 + hypothetical protein SCG22.18%2C unknown%2C len: 73 aa. High G+C content (84.01%25) gene gene1058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1072 SCO1073 SCO1073 SCG22.19c SCG22.19c 1132744 1134012 - hydrogenase SCG22.19c%2C possible hydrogenase%2C len: 422 aa%3B similar to SW:BCHP_RHOCA (EMBL:Z11165) Rhodobacter capsulatus geranylgeranyl hydrogenase BchP%2C 391 aa%3B fasta scores: opt: 386 z-score: 432.9 E(): 1.2e-16%3B 33.2%25 identity in 319 aa overlap. Contains Pfam match to entry PF01494 FAD_binding_3%2C FAD binding domain gene gene1059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1073 SCO1074 SCO1074 SCG22.20 SCG22.20 1134157 1135512 + hypothetical protein SCG22.20%2C possible peptidase%2C len: 451 aa%3B similar to TR:Q9X7E4 (EMBL:AL049478) Mycobacterium leprae hypothetical 46.6 kD protein%2C 442 aa%3B fasta scores: opt: 1103 z-score: 1270.5 E(): 0%3B 43.8%25 identity in 443 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20%2C Peptidase family M20/M25/M40 gene gene1060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1074 SCO1075 SCO1075 SCG22.21c SCG22.21c 1135646 1136689 - hypothetical protein SCG22.21c%2C possible bifunctional protein (ATP/GTP binding protein/MutT-like)%2C len: 347 aa%3B N-terminal domain similar to TR:O88042 (EMBL:AL031541) Streptomyces coelicolor ATP/GTP binding protein SCI35.04c%2C 174 aa%3B fasta scores: opt: 462 z-score: 521.1 E(): 1.5e-21%3B 47.2%25 identity in 180 aa overlap and C-terminal domain similar to TR:CAB85162 (EMBL:AL162757) Neisseria meningitidis MutT-like protein NMA1942%2C 174 aa%3B fasta scores: opt: 148 z-score: 174.6 E(): 0.03%3B 28.9%25 identity in 121 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1075 SCO1076 SCO1076 SCG22.22c SCG22.22c 1136858 1137052 - hypothetical protein SCG22.22c%2C possible hypothetical protein%2C len: 64 aa. Contains possible N-terminal region signal peptide sequence gene gene1062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1076 SCO1077 SCO1077 SCG22.23c SCG22.23c 1137148 1138101 - sugar kinase SCG22.23c%2C probable sugar kinase%2C len: 317 aa%3B similar to SW:GLK_BACSU (EMBL:D84432) Bacillus subtilis glucokinase (EC 2.7.1.2) GlcK%2C 321 aa%3B fasta scores: opt: 495 z-score: 504.0 E(): 1.3e-20%3B 31.4%25 identity in 312 aa overlap. Contains match to Prosite entry PS01125 ROK family signature gene gene1063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1077 SCO1078 SCO1078 SCG22.24 SCG22.24 1138342 1139391 + LacI family transcriptional regulator SCG22.24%2C probable lacI-family transcriptional regulator%2C len: 349 aa%3B similar to TR:Q9S1T0 (EMBL:AL109950) Streptomyces coelicolor lacI-family transcriptional regulator SCJ4.43c%2C 367 aa%3B fasta scores: opt: 786 z-score: 894.0 E(): 0%3B 38.5%25 identity in 353 aa overlap and to SW:GALR_ECOLI (EMBL:V00280) Escherichia coli galactose operon repressor GalR%2C 343 aa%3B fasta scores: opt: 504 z-score: 575.9 E(): 1.3e-24%3B 31.3%25 identity in 336 aa overlap. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Contains also a possible helix-turn-helix motif at residues 29..50 (+4.16 SD) gene gene1064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1078 SCO1079 SCO1079 SCG22.25 SCG22.25 1139479 1140312 + hypothetical protein SCG22.25%2C hypothetical protein%2C len: 277 aa%3B similar to TR:CAB88921 (EMBL:AL353862) Streptomyces coelicolor oxidoreductase SCE34.18%2C 443 aa%3B fasta scores: opt: 133 z-score: 155.6 E(): 0.34%3B 28.2%25 identity in 287 aa overlap gene gene1065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1079 SCO1080 SCO1080 SCG22.26c SCG22.26c 1140293 1141591 - hypothetical protein SCG22.26c%2C hypothetical protein%2C len: 432 aa%3B C-terminal domain similar to TR:Q9ZBK3 (EMBL:AL035161) Streptomyces coelicolor lyase SC9C7.07c%2C 339 aa%3B fasta scores: opt: 163 z-score: 187.9 E(): 0.0054%3B 27.7%25 identity in 206 aa overlap gene gene1066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1080 SCO1081 SCO1081 SCG22.27c SCG22.27c 1141759 1142721 - electron transfer flavoprotein subunit alpha SCG22.27c%2C probable electron transfer flavoprotein%2C alpha subunit%2C len: 320 aa%3B similar to SW:ETFA_PARDE (EMBL:L14864) Paracoccus denitrificans electron transfer flavoprotein%2C alpha subunit EftA%2C 307 aa%3B fasta scores: opt: 673 z-score: 707.8 E(): 6e-32%3B 44.3%25 identity in 316 aa overlap and to SW:ETFA_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis electron transfer flavoprotein alpha-subunit EftA or MTV012.43c%2C 318 aa%3B fasta scores: opt: 1161 z-score: 1212.8 E(): 0%3B 59.4%25 identity in 323 aa overlap. Contains Pfam match to entry PF00766 ETF_alpha%2C Electron transfer flavoprotein alpha subunit and match to Prosite entry PS00696 Electron transfer flavoprotein alpha-subunit signature gene gene1067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1081 SCO1082 SCO1082 SCG22.28c SCG22.28c 1142777 1143565 - electron transfer flavoprotein subunit beta SCG22.28c%2C probable electron transfer flavoprotein%2C beta subunit%2C len: 262 aa%3B similar to SW:ETFB_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis electron transfer flavoprotein%2C beta subunit FixA or MTV012.44c%2C 266 aa%3B fasta scores: opt: 860 z-score: 939.3 E(): 0%3B 52.5%25 identity in 263 aa overlap. Contains Pfam match to entry PF01012 ETF_beta%2C Electron transfer flavoprotein beta subunit gene gene1068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1082 SCO1083 SCO1083 SCG22.29c SCG22.29c 1143786 1144295 - flavin-dependent reductase SCG22.29c%2C probable flavin-dependent reductase%2C len: 169 aa%3B similar to TR:O68503 (EMBL:AF048979) Rhodococcus erythropolis NADH-dependent FMN oxydoreductase DszD%2C 192 aa%3B fasta scores: opt: 444 z-score: 517.7 E(): 2.3e-21%3B 44.6%25 identity in 168 aa overlap. Contains Pfam match to entry PF01613 Flavin_Reduct%2C Flavin reductase like domain gene gene1069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1083 SCO1084 SCO1084 SCG22.30c SCG22.30c 1144442 1144822 - thioredoxin SCG22.30c%2C possible thioredoxin%2C len: 126 aa%3B similar to TR:Q50039 (EMBL:U15182) Mycobacterium leprae ThiX%2C 172 aa%3B fasta scores: opt: 253 z-score: 318.8 E(): 2.8e-10%3B 40.6%25 identity in 101 aa overlap%2C 172 and to SW:THIO_MYCSM (EMBL:AF023161) Mycobacterium smegmatis thioredoxin TrxA%2C 112 aa%3B fasta scores: opt: 147 z-score: 193.6 E(): 0.0026%3B 28.4%25 identity in 109 aa overlap. Contains match to Prosite entry PS00194 Thioredoxin family active site gene gene1070 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1084 SCO1085 SCO1085 2SCG4.01 2SCG4.01 1145088 1145816 + acyltransferase 2SCG4.01%2C probable acyltransferase%2C len: 242 aa%3B similar to TR:O0780 (EMBL:Z97188) Mycobacterium tuberculosis acyltransferase MTCY409.14%2C 259 aa%3B fasta scores: opt: 758 z-score: 928.7 E(): 0%3B 51.7%25 identity in 234 aa overlap and to SW:PLSC_LIMDO (EMBL:X83266) Limnanthes douglasii 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) PlsC%2C 281 aa%3B fasta scores: opt: 218 z-score: 272.2 E(): 1.1e-07%3B 31.0%25 identity in 174 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase%2C Acyltransferase gene gene1071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1085 SCO1086 SCO1086 2SCG4.02c 2SCG4.02c 1145827 1146426 - hypothetical protein 2SCG4.02c%2C hypothetical protein%2C len: 199 aa%3B similar to TR:P71843 (EMBL:Z80226) Mycobacterium tuberculosis hypothetical 26.7 kD protein MTCY369.34c%2C 242 aa%3B fasta scores: opt: 168 z-score: 213.2 E(): 0.00022%3B 29.7%25 identity in 111 aa overlap gene gene1072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1086 SCO1087 SCO1087 2SCG4.03c 2SCG4.03c 1146486 1147556 - aldolase 2SCG4.03c%2C probable aldolase%2C len: 356 aa%3B similar to TR:O50584 (EMBL:AB001577) Pseudomonas sp. low specificity L-threonine aldolase%2C 346 aa%3B fasta scores: opt: 832 z-score: 977.3 E(): 0%3B 41.3%25 identity in 339 aa overlap and to SW:LTAA_AERJA (EMBL:D87890) Aeromonas jandaei L-allo-threonine aldolase (EC 4.1.2.-) LtaA%2C 338 aa%3B fasta scores: opt: 270 z-score: 321.1 E(): 2.1e-10%3B 26.9%25 identity in 324 aa overlap gene gene1073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1087 SCO1088 SCO1088 2SCG4.04c 2SCG4.04c 1147553 1148371 - oxidoreductase gene gene1074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1088 SCO1089 SCO1089 2SCG4.05c 2SCG4.05c 1148368 1149771 - hypothetical protein 2SCG4.05c%2C unknown%2C len: 467 aa. High content in alanine%2C asparagine and valine amino acid residues gene gene1075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1089 SCO1090 SCO1090 2SCG4.06 2SCG4.06 1149998 1150681 + phosphodiesterase 2SCG4.06%2C possible phosphodiesterase%2C len: 227 aa%3B similar to TR:Q9RKX8 (EMBL:AL133213) Streptomyces coelicolor phosphodiesterase SC6D7.20c%2C 255 aa%3B fasta scores: opt: 287 z-score: 341.1 E(): 1.6e-11%3B 33.9%25 identity in 230 aa overlap and to SW:GLPQ_BACSU (EMBL:Z26522) Bacillus subtilis glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) GlpQ%2C 293 aa%3B fasta scores: opt: 268 z-score: 318.3 E(): 3e-10%3B 30.8%25 identity in 247 aa overlap gene gene1076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1090 SCO1091 SCO1091 2SCG4.07c 2SCG4.07c 1150733 1151272 - acetyltransferase 2SCG4.07c%2C possible acetyltransferase%2C len: 179 aa%3B similar to TR:Q9ZBJ7 (EMBL:AL035161) Streptomyces coelicolor hypothetical 19.8 kD protein SC9C7.13c%2C 179 aa%3B fasta scores: opt: 131 z-score: 171.3 E(): 0.047%3B 29.3%25 identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1091 SCO1092 SCO1092 2SCG4.08 2SCG4.08 1151356 1151748 + hypothetical protein 2SCG4.08%2C conserved hypothetical protein%2C len: 130 aa%3B similar to TR:O06412 (EMBL:Z95558%3B) Mycobacterium tuberculosis hypothetical 14.3 kD protein MTCY25D10.25c%2C 128 aa%3B fasta scores: opt: 399 z-score: 498.2 E(): 2.9e-20%3B 48.4%25 identity in 128 aa overlap gene gene1078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1092 SCO1093 SCO1093 2SCG4.09 2SCG4.09 1151783 1152634 + hydroxylase 2SCG4.09%2C possible hydroxylase%2C len: 283 aa%3B similar to TR:O50527 (EMBL:AL009204) Streptomyces coelicolor hydroxylase SC9B10.20c%2C 267 aa%3B fasta scores: opt: 534 z-score: 593.2 E(): 1.5e-25%3B 37.0%25 identity in 270 aa overlap. Contains a TTA leucine codon%2C possible target for bldA regulation gene gene1079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1093 SCO1094 SCO1094 2SCG4.10 2SCG4.10 1152798 1153376 + TetR family transcriptional regulator 2SCG4.10%2C probable tetR-family regulatory protein%2C len: 192 aa%3B similar to TR:CAB69777 (EMBL:AL137187) Streptomyces coelicolor tetR-family transcriptional regulator SC7A8.28%2C 194 aa%3B fasta scores: opt: 419 z-score: 522.7 E(): 1.3e-21%3B 39.7%25 identity in 194 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene1080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1094 SCO1095 SCO1095 2SCG4.11 2SCG4.11 1153488 1154504 + hypothetical protein 2SCG4.11%2C unknown%2C len: 338 aa. Contains highly hydrophilic C-terminal region gene gene1081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1095 SCO1096 SCO1096 2SCG4.12 2SCG4.12 1154572 1154766 + hypothetical protein 2SCG4.12%2C unknown%2C len: 64 aa gene gene1082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1096 SCO1097 SCO1097 2SCG4.13 2SCG4.13 1154808 1155686 + hydrolase 2SCG4.13%2C probable hydrolase%2C len: 292 aa%3B similar to TR:O52866 (EMBL:AJ224332) Corynebacterium sp. soluble epoxide hydrolase (EC 3.3.2.3) Ceh%2C 285 aa%3B fasta scores: opt: 601 z-score: 728.8 E(): 0%3B 35.8%25 identity in 288 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene1083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1097 SCO1098 SCO1098 2SCG4.14c 2SCG4.14c 1155717 1156292 - MarR family regulatory protein 2SCG4.14c%2C probable MarR-family regulatory protein%2C len: 191 aa%3B similar to SW:PECS_ERWCH (EMBL:X74409) Erwinia chrysanthemi regulatory protein PecS%2C 166 aa%3B fasta scores: opt: 302 z-score: 329.2 E(): 7.5e-11%3B 34.0%25 identity in 150 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene1084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1098 SCO1099 SCO1099 2SCG4.15c 2SCG4.15c 1156289 1158022 - hypothetical protein 2SCG4.15c%2C possible integral membrane protein%2C len: 577 aa%3B similar to TR:O32225 (EMBL:Z99121) Bacillus subtilis YvaC protein%2C 631 aa%3B fasta scores: opt: 259 z-score: 265.7 E(): 2.6e-07%3B 26.5%25 identity in 578 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1099 SCO1100 SCO1100 2SCG4.16 2SCG4.16 1158218 1158796 + hypothetical protein 2SCG4.16%2C possible integral membrane protein%2C len: 192 aa. Contains possible hydrophobic membrane spanning regions gene gene1086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1100 SCO1101 SCO1101 2SCG4.17 2SCG4.17 1158944 1159879 + hypothetical protein 2SCG4.17%2C possible integral membrane protein%2C len: 311 aa%3B similar to TR:Q9XAS1 (EMBL:AL078618) Streptomyces coelicolor integral membrane protein SC10A7.04%2C 312 aa%3B fasta scores: opt: 1123 z-score: 1310.0 E(): 0%3B 56.4%25 identity in 305 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1101 SCO1102 SCO1102 2SCG4.18 2SCG4.18 1160123 1160794 + hypothetical protein 2SCG4.18%2C possible integral membrane protein%2C len: 223 aa%3B similar to TR:Q06074 (EMBL:Z21972) Bacillus megaterium hypothetical 24.9 kD protein in cytochrome P450MEG gene 3' region%2C 216 aa%3B fasta scores: opt: 298 z-score: 353.5 E(): 3.3e-12%3B 27.5%25 identity in 207 aa overlap. Contains Pfam match to entry PF01569 PAP2%2C PAP2 superfamily. Also contains possible hydrophobic membrane spanning regions gene gene1088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1102 SCO1103 SCO1103 2SCG4.19 2SCG4.19 1160876 1161565 + hydrolase 2SCG4.19%2C probable hydrolase%2C len: 229 aa%3B similar to SW:HAD4_BURCE (EMBL:X66249) Burkholderia cepacia 2-haloalkanoic acid dehalogenase IVa (EC 3.8.1.2) Hdl IVa%2C 230 aa%3B fasta scores: opt: 218 z-score: 257.2 E(): 7.6e-07%3B 29.8%25 identity in 205 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene1089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1103 SCO1104 SCO1104 2SCG4.20 2SCG4.20 1161710 1162411 + TetR family transcriptional regulator 2SCG4.20%2C probable tetR-family transcriptional regulatory protein%2C len: 233 aa%3B similar to SW:BETI_ECOLI (EMBL:X52905) Escherichia coli regulatory protein BetI%2C 195 aa%3B fasta scores: opt: 177 z-score: 211.3 E(): 0.00027%3B 24.5%25 identity in 196 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains possible helix-turn-helix at residues 36..57 (+3.64 SD) gene gene1090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1104 SCO1105 SCO1105 2SCG4.21c 2SCG4.21c 1162399 1163901 - hypothetical protein 2SCG4.21c%2C possible hypothetical protein%2C len: 500 aa. Contains possible N-terminal region signal peptide sequence gene gene1091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1105 SCO1106 SCO1106 2SCG4.22 2SCG4.22 1164110 1164766 + lipoprotein 2SCG4.22%2C possible lipoprotein%2C len: 218 aa%3B similar to C-terminal region of TR:Q9RVD0 (EMBL:AE001960) Deinococcus radiodurans conserved hypothetical protein DR1099%2C 197 aa%3B fasta scores: opt: 263 z-score: 286.8 E(): 1.7e-08%3B 35.4%25 identity in 147 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene1092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1106 SCO1107 SCO1107 2SCG4.23c 2SCG4.23c 1164809 1165264 - hypothetical protein 2SCG4.23c%2C unknown%2C len: 151 aa gene gene1093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1107 SCO1108 SCO1108 2SCG38.01c 2SCG38.01c 1165403 1165774 - regulatory protein 2SCG38.01c%2C possible regulatory protein(fragment)%2C len: >106 aa%3B similar to N-terminal region of TR:CAC01635 (EMBL:AL391072) Streptomyces coelicolor regulatory protein SC9A4.08%2C 116 aa%3B fasta scores: opt: 218 z-score: 308.8 E(): 9.3e-10%3B 46.2%25 identity in 91 aa overlap~2SCG4.24c%2C hypothetical protein (fragment)%2C len: >47 aa%3B similar to TR:CAB82870 (EMBL:AJ276673) Streptomyces coelicolor hypothetical 12.1 kD protein MmyJ%2C 111 aa%3B fasta scores: opt: 166 z-score: 266.6 E(): 2.3e-07%3B 68.4%25 identity in 38 aa overlap gene gene1094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1108 SCO1109 SCO1109 2SCG38.02 2SCG38.02 1165916 1166995 + oxidoreductase 2SCG38.02%2C probable oxidoreductase%2C len: 359 aa%3B similar to SW:NEMA_ECOLI (EMBL:D86931) Escherichia coli N-ethylmaleimide reductase (EC 1.-.-.-) NemA%2C 365 aa%3B fasta scores: opt: 509 z-score: 564.1 E(): 5.6e-24%3B 32.1%25 identity in 364 aa overlap. Contains Pfam match to entry PF00724 oxidored_FMN%2C NADH:flavin oxidoreductase / NADH oxidase family gene gene1095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1109 SCO1110 SCO1110 2SCG38.03 2SCG38.03 1167193 1167993 + lyase 2SCG38.03%2C probable lyase%2C len: 266 aa%3B similar to TR:Q04701 (EMBL:M94691) Fusarium solani pectate lyase A precursor (EC 4.2.2.2) PelA%2C 242 aa%3B fasta scores: opt: 605 z-score: 664.1 E(): 1.5e-29%3B 43.6%25 identity in 236 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1110 SCO1111 SCO1111 2SCG38.04c 2SCG38.04c 1167998 1168804 - hypothetical protein 2SCG38.04c%2C conserved hypothetical protein%2C len: 268 aa%3B similar to TR:O53782 (EMBL:AL021943) Mycobacterium tuberculosis hypothetical 26.5 kDa protein MTV040.02%2C 240 aa%3B fasta scores: opt: 735 z-score: 848.5 E(): 0%3B 51.4%25 identity in 218 aa overlap gene gene1097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1111 SCO1112 SCO1112 2SCG38.05 2SCG38.05 1168853 1170556 + oxidoreductase 2SCG38.05%2C probable oxidoreductase%2C len: 567 aa%3B similar to SW:AIDB_ECOLI (EMBL:L20915) Escherichia coli acyl-CoA dehydrogenase%3B adaptive response AidB protein%2C 541 aa%3B fasta scores: opt: 1437 z-score: 1553.6 E(): 0%3B 45.8%25 identity in 517 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and match to Prosite entry PS00073 Acyl-CoA dehydrogenases signature 2 gene gene1098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1112 SCO1113 SCO1113 2SCG38.06 2SCG38.06 1170638 1171792 + hypothetical protein 2SCG38.06%2C conserved hypothetical protein%2C len: 384 aa%3B similar to TR:AAG04745 (EMBL:AE004565) Pseudomonas aeruginosa hypothetical 41.0 kDa protein PA1356%2C 368 aa%3B fasta scores: opt: 714 z-score: 833.2 E(): 0%3B 36.9%25 identity in 374 aa overlap. Contains 6x Pfam matches to entry PF02012 BNR%2C BNR repeat gene gene1099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1113 SCO1114 SCO1114 2SCG38.07 2SCG38.07 1171863 1172540 + uracil-DNA glycosylase Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine gene gene1100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1114 SCO1115 SCO1115 2SCG38.08 2SCG38.08 1172537 1173535 + hypothetical protein 2SCG38.08%2C hypothetical protein%2C len: 332 aa%3B similar to TR:O50524 (EMBL:AL009204) Streptomyces coelicolor hypothetical 34.4 kDa protein SC9B10.17%2C 330 aa%3B fasta scores: opt: 263 z-score: 269.2 E(): 1.5e-07%3B 29.2%25 identity in 329 aa overlap and to TR:Q9EWI7 (EMBL:AL450223) Streptomyces coelicolor hypothetical protein SC7H9.09c%2C 332 aa%3B fasta scores: opt: 619 Z-score: 612.5 E(): 1.7e-26%3B 45.289%25 identity in 329 aa overlap gene gene1101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1115 SCO1116 SCO1116 2SCG38.09 2SCG38.09 1173674 1174600 + hypothetical protein 2SCG38.09%2C hypothetical protein%2C len: 338 aa%3B similar to TR:P71751 (EMBL:Z81368) Mycobacterium tuberculosis hypothetical 29.7 kDa protein MTCY253.28c%2C 281 aa%3B fasta scores: opt: 210 z-score: 227.0 E(): 3.4e-05%3B 29.1%25 identity in 282 aa overlap gene gene1102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1116 SCO1117 SCO1117 2SCG38.10c 2SCG38.10c 1174890 1175927 - hypothetical protein 2SCG38.10c%2C possible hypothetical protein%2C len: 345 aa%3B similar to TR:Q9RD79 (EMBL:AL136502) Streptomyces coelicolor hypothetical 41.5 kDa protein SCF43.09%2C 411 aa%3B fasta scores: opt: 813 z-score: 857.3 E(): 0%3B 44.1%25 identity in 358 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1117 SCO1118 SCO1118 2SCG38.11c 2SCG38.11c 1176089 1177579 - hypothetical protein 2SCG38.11c%2C possible integral membrane protein%2C len: 496 aa%3B low similarity to TR:AAG03843 (EMBL:AE004483) Pseudomonas aeruginosa conserved hypothetical protein PA0454%2C 733 aa%3B fasta scores: opt: 224 z-score: 245.0 E(): 3.3e-06%3B 28.0%25 identity in 300 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1118 SCO1119 SCO1119 2SCG38.12 2SCG38.12 1177797 1178273 + transcription regulator AsnC 2SCG38.12%2C probable asnC-family transcriptional regulatory protein%2C len: 158 aa%3B similar to SW:PUTR_RHOCA (EMBL:X78346) Rhodobacter capsulatus proline dehydrogenase transcriptional activator PutR%2C 154 aa%3B fasta scores: opt: 245 z-score: 306.6 E(): 1.2e-09%3B 34.3%25 identity in 143 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and possible helix-turn-helix motif at residues 20..41 (+2.62 SD) gene gene1105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1119 SCO1120 SCO1120 2SCG38.13 2SCG38.13 1178294 1179010 + hydrolase 2SCG38.13%2C probable hydrolase%2C len: 238 aa%3B similar to SW:GPHC_ALCEU (EMBL:M68904) Alcaligenes eutrophus phosphoglycolate phosphatase%2C chromosomal (EC 3.1.3.18) CbbZC%2C 231 aa%3B fasta scores: opt: 300 z-score: 354.5 E(): 2.7e-12%3B 32.9%25 identity in 207 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene1106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1120 SCO1121 SCO1121 2SCG38.14 2SCG38.14 1179094 1179834 + hypothetical protein 2SCG38.14%2C possible hypothetical protein%2C len: 246 aa%3B highly similar to TR:Q9XAG0 (EMBL:AL079356) Streptomyces coelicolor hypothetical protein SC6G9.22%2C 248 aa%3B fasta scores: opt: 1111 z-score: 1110.0 E(): 0%3B 66.8%25 identity in 244 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1121 SCO1122 SCO1122 2SCG38.15c 2SCG38.15c 1179956 1180792 - regulatory protein 2SCG38.15c%2C possible regulatory protein%2C len: 278 aa%3B similar to TR:Q9RIT6 (EMBL:AL133278) Streptomyces coelicolor lysR-family transcriptional regulator SCM11.26%2C 303 aa%3B fasta scores: opt: 243 z-score: 243.1 E(): 4.2e-06%3B 33.9%25 identity in 168 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1122 SCO1123 SCO1123 2SCG38.16 2SCG38.16 1180851 1181249 + hypothetical protein 2SCG38.16%2C unknown%2C len: 132 aa gene gene1109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1123 SCO1124 SCO1124 2SCG38.17c 2SCG38.17c 1181366 1181857 - hypothetical protein 2SCG38.17c%2C possible integral membrane protein%2C len: 163 aa%3B similar to TR:O31623 (EMBL:Z99110) Bacillus subtilis YjcA protein%2C 118 aa%3B fasta scores: opt: 229 z-score: 294.7 E(): 5.7e-09%3B 38.2%25 identity in 110 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1124 SCO1125 SCO1125 2SCG38.18c 2SCG38.18c 1181900 1182421 - hypothetical protein 2SCG38.18c%2C unknown%2C len: 173 aa gene gene1111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1125 SCO1126 SCO1126 2SCG38.19c 2SCG38.19c 1182418 1183572 - hypothetical protein 2SCG38.19c%2C conserved hypothetical protein%2C len: 384 aa%3B similar to TR:Q9RVF3 (EMBL:AE001958) Deinococcus radiodurans cell wall synthesis protein%2C DR1076%2C 411 aa%3B fasta scores: opt: 327 z-score: 366.3 E(): 5.8e-13%3B 30.2%25 identity in 397 aa overlap gene gene1112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1126 SCO1127 SCO1127 2SCG38.20 2SCG38.20 1183673 1184611 + oxidoreductase 2SCG38.20%2C probable oxidoreductase%2C len: 312 aa%3B similar to SW:BDHA_RHIME (EMBL:AF080548) Rhizobium meliloti D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30) BdhA%2C 258 aa%3B fasta scores: opt: 332 z-score: 358.5 E(): 1.6e-12%3B 32.7%25 identity in 223 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene1113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1127 SCO1128 SCO1128 2SCG38.21 2SCG38.21 1184628 1185536 + hypothetical protein 2SCG38.21%2C possible integral membrane protein%2C len: 302 aa%3B similar to TR:Q9RJN5 (EMBL:AL132991) Streptomyces coelicolor integral membrane protein SCF55.33%2C 287 aa%3B fasta scores: opt: 590 z-score: 654.2 E(): 5.4e-29%3B 42.4%25 identity in 278 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1128 SCO1129 SCO1129 2SCG38.22 2SCG38.22 1185632 1186480 + deacetylase 2SCG38.22%2C probable deacetylase%2C len: 282 aa%3B similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) NodB%2C 217 aa%3B fasta scores: opt: 363 z-score: 383.5 E(): 6.5e-14%3B 38.5%25 identity in 195 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet%2C Polysaccharide deacetylase and possible N-terminal region signal peptide sequence gene gene1115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1129 SCO1130 SCO1130 2SCG38.23 2SCG38.23 1186491 1188266 + hypothetical protein 2SCG38.23%2C conserved hypothetical protein%2C len: 591 aa%3B similar to TR:P71741 (EMBL:Z81368) Mycobacterium tuberculosis hypothetical 72.7 kDa protein MTCY253.18c%2C 642 aa%3B fasta scores: opt: 339 z-score: 399.9 E(): 7.9e-15%3B 29.0%25 identity in 628 aa overlap gene gene1116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1130 SCO1131 SCO1131 2SCG38.24c 2SCG38.24c 1188324 1189481 - hypothetical protein 2SCG38.24c%2C conserved hypothetical protein%2C len: 385 aa%3B similar to TR:O53711 (EMBL:AL021931) Mycobacterium tuberculosis hypothetical 39.9 kDa protein MTV036.11c%2C 380 aa%3B fasta scores: opt: 1176 z-score: 1285.6 E(): 0%3B 56.7%25 identity in 351 aa overlap and to TR:Q9ZBN5 (EMBL:AL034492) Streptomyces coelicolor hypothetical 40.7 kDa protein SC6C5.10%2C 395 aa%3B fasta scores: opt: 1764 z-score: 1925.1 E(): 0%3B 76.9%25 identity in 351 aa overlap gene gene1117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1131 SCO1132 SCO1132 2SCG38.25c 2SCG38.25c 1189474 1191621 - oxidoreductase 2SCG38.25c%2C possible oxidoreductase%2C len: 715 aa%3B similar to TR:AAG05321 (EMBL:AE004619) Pseudomonas aeruginosa probable hydroxylase large subunit PA1933%2C 734 aa%3B fasta scores: opt: 1323 z-score: 1465.6 E(): 0%3B 44.2%25 identity in 737 aa overlap and to TR:CAB69663 (EMBL:AL137165) Streptomyces coelicolor oxidoreductase SCF42.01%2C 369 aa%3B fasta scores: opt: 1286 z-score: 1141.0 E(): 0%3B 55.4%25 identity in 359 aa overlap. Contains 3x Pfam matches to entry PF01315 Ald_Xan_dh_C%2C Aldehyde oxidase and xanthine dehydrogenase%2C C terminus gene gene1118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1132 SCO1133 SCO1133 2SCG38.26c 2SCG38.26c 1191618 1192610 - oxidoreductase%2C molybdopterin binding subunit 2SCG38.26c%2C probable oxidoreductase%2C molybdopterin binding subunit%2C len: 330 aa%3B similar to TR:AAG05320 (EMBL:AE004619) Pseudomonas aeruginosa probable hydroxylase molybdopterin-containing subunit PA1932%2C 329 aa%3B fasta scores: opt: 1032 z-score: 1156.3 E(): 0%3B 52.0%25 identity in 325 aa overlap and to TR:Q9RK26 (EMBL:AL132856) Streptomyces coelicolor possible oxidoreductase%2C molybdopterin binding subunit SCF15.11%2C 330 aa%3B fasta scores: opt: 1254 z-score: 1403.4 E(): 0%3B 62.0%25 identity in 326 aa overlap. Contains Pfam match to entry PF00941 dehydrog_molyb%2C Molybdopterin binding domain in dehydrogenase gene gene1119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1133 SCO1134 SCO1134 2SCG38.27c 2SCG38.27c 1192607 1193209 - oxidoreductase%2C iron-sulfur binding subunit 2SCG38.27c%2C probable oxidoreductase%2C iron-sulphur binding subunit%2C len: 200 aa%3B similar to TR:Q52589 (EMBL:X77931) Pseudomonas thermocarboxydovorans carbon monoxide oxygenase [cytochrome B-561]%2C small chain (EC 1.2.2.4) CutC%2C 163 aa%3B fasta scores: opt: 405 z-score: 478.3 E(): 3.4e-19%3B 45.6%25 identity in 169 aa overlap and to TR:Q9RK27 (EMBL:AL132856) Streptomyces coelicolor oxidoreductase%2C iron-sulphur binding subunit StF15.10%2C 211 aa%3B fasta scores: opt: 729 z-score: 804.0 E(): 0%3B 62.3%25 identity in 175 aa overlap. Contains Pfam matches to entries PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains and PF01799 fer2_2%2C [2Fe-2S] binding domain and matches to Prosite entries PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature and PS00070 Aldehyde dehydrogenases cysteine active site gene gene1120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1134 SCO1135 SCO1135 2SCG38.28 2SCG38.28 1193398 1193988 + TetR family transcriptional regulator 2SCG38.28%2C probable tetR-family transcriptional regulator%2C len: 196 aa%3B highly similar to TR:Q9RJL5 (EMBL:AL121849) Streptomyces coelicolor tetR-family transcriptional regulator SCF6.16%2C 194 aa%3B fasta scores: opt: 461 z-score: 557.4 E(): 1.3e-23%3B 40.7%25 identity in 189 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 38..59 (+4.25 SD) gene gene1121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1135 SCO1136 SCO1136 2SCG38.29c 2SCG38.29c 1193951 1194742 - two component system response regulator 2SCG38.29c%2C probable two component system response regulator%2C len: 263 aa%3B similar to SW:DCUR_ECOLI (EMBL:U14003) Escherichia coli transcriptional regulatory protein DcuR%2C 239 aa%3B fasta scores: opt: 421 z-score: 469.7 E(): 1e-18%3B 35.0%25 identity in 226 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and possible helix-turn-helix motif at residues 201.222 (+3.87 SD) gene gene1122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1136 SCO1137 SCO1137 2SCG38.30c 2SCG38.30c 1194739 1196385 - two component system histidine kinase 2SCG38.30c%2C probable two component system histidine kinase%2C len: 548 aa%3B similar to SW:DCUS_ECOLI (EMBL:U14003) Escherichia coli sensor protein (EC 2.7.3.-) DcuS%2C 543 aa%3B fasta scores: opt: 657 z-score: 720.4 E(): 1.1e-32%3B 27.0%25 identity in 529 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase and possible hydrophobic membrane spanning regions gene gene1123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1137 SCO1138 SCO1138 2SCG38.31 2SCG38.31 1196781 1197779 + hypothetical protein 2SCG38.31%2C possible hypothetical protein%2C len: 332 aa%3B similar to TR:AAG04143 (EMBL:AE004510) Pseudomonas aeruginosa hypothetical 34.9 kD protein PA0754%2C 327 aa%3B fasta scores: opt: 503 z-score: 536.4 E(): 2e-22%3B 29.0%25 identity in 328 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1138 SCO1139 SCO1139 2SCG38.32 2SCG38.32 1197776 1198321 + hypothetical protein 2SCG38.32%2C possible integral membrane protein%2C len: 181 aa. Contains possible hydrophobic membrane spanning regions gene gene1125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1139 SCO1140 SCO1140 2SCG38.33 2SCG38.33 1198323 1199822 + hypothetical protein 2SCG38.33%2C possible integral membrane protein%2C len: 499 aa%3B similar to SW:YZ2R_AGRVI (EMBL:U32375) Agrobacterium vitis hypothetical 52.8 kDa protein%2C 502 aa%3B fasta scores: opt: 1419 z-score: 1523.5 E(): 0%3B 44.1%25 identity in 479 aa overlap. Contains Pfam match to entry PF01970 DUF112%2C Integral membrane protein DUF112. Also contains possible hydrophobic membrane spanning regions gene gene1126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1140 SCO1141 SCO1141 2SCG38.34c 2SCG38.34c 1199889 1200311 - hypothetical protein 2SCG38.34c%2C conserved hypothetical protein%2C len: 140 aa%3B similar to SW:YP56_MYCTU (EMBL:Z77250) Mycobacterium tuberculosis hypothetical 13.9 kDa protein MTCY9C4.12%2C 129 aa%3B fasta scores: opt: 487 z-score: 626.4 E(): 1.9e-27%3B 61.2%25 identity in 121 aa overlap. Contains Pfam match to entry PF01894 UPF0047%2C Uncharacterised protein family UPF0047 gene gene1127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1141 SCO1142 SCO1142 2SCG38.35 2SCG38.35 1200394 1201473 + oxidoreductase 2SCG38.35%2C possible oxidoreductase%2C len: 359 aa%3B similar to TR:Q9X8X9 (EMBL:AL078610) Streptomyces coelicolor oxidoreductase SCH35.27%2C 406 aa%3B fasta scores: opt: 670 z-score: 758.0 E(): 0%3B 50.6%25 identity in 235 aa overlap. Contains Pfam match to entry PF00743 FMO-like%2C Flavin-binding monooxygenase-like gene gene1128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1142 SCO1143 SCO1143 2SCG38.36c 2SCG38.36c 1201486 1202247 - hypothetical protein 2SCG38.36c%2C conserved hypothetical protein%2C len: 253 aa%3B similar to TR:O66972 (EMBL:AE000707) Aquifex aeolicus hypothetical 38.3 kDa protein AQ_775%2C 326 aa%3B fasta scores: opt: 376 z-score: 435.0 E(): 8.8e-17%3B 32.8%25 identity in 235 aa overlap gene gene1129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1143 SCO1144 SCO1144 2SCG38.37c 2SCG38.37c 1202480 1204282 - ABC transporter ATP-binding protein 2SCG38.37c%2C possible ABC transporter ATP-binding protein%2C len: 600 aa%3B similar to TR:P71082 (EMBL:Z82044) Bacillus subtilis unidentified transporter-ATP binding YgaD%2C 589 aa%3B fasta scores: opt: 1229 z-score: 1240.6 E(): 0%3B 34.2%25 identity in 576 aa overlap. Contains Pfam matches to entries PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains possible hydrophobic membrane spanning regions gene gene1130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1144 SCO1145 SCO1145 2SCG38.38 2SCG38.38 1204428 1204889 + MarR family regulatory protein 2SCG38.38%2C possible marR-family regulator%2C len: 153 aa%3B similar to TR:Q9RDN9 (EMBL:AL133423) Streptomyces coelicolor marR-family transcriptional regulator SC4A7.26%2C 151 aa%3B fasta scores: opt: 200 z-score: 252.2 E(): 1.3e-06%3B 36.1%25 identity in 147 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene1131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1145 SCO1146 SCO1146 2SCG38.39c 2SCG38.39c 1204911 1205669 - lipoprotein 2SCG38.39c%2C possible lipoprotein%2C len: 252 aa%3B similar to TR:Q9RK82 (EMBL:AL132662) Streptomyces coelicolor hypothetical 26.4 kDa protein SCF11.08%2C 250 aa%3B fasta scores: opt: 645 z-score: 660.7 E(): 2.4e-29%3B 42.1%25 identity in 247 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene1132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1146 SCO1147 SCO1147 2SCG38.40 2SCG38.40 1205898 1207775 + ABC transporter transmembrane subunit 2SCG38.40%2C probable ABC transporter transmembrane protein (fragment)%2C len: >35 aa~SCG8A.01%2C partial CDS%2C probable ABC transporter transmembrane subunit%2C len: >623aa%3B similar to many eg. TR:O87312 (EMBL:AF027770) FxtA iron sequestration protein from Mycobacterium smegmatis (574 aa) fasta scores%3B opt: 794%2C z-score: 866.3%2C E(): 0%2C 35.2%25 identity in 514 aa overlap. Contains Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region%2C Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite match to PS00211 ABC transporters family signature. Also contains possible membrane-spanning hydrophobic regions. gene gene1133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1147 SCO1148 SCO1148 SCG8A.02 SCG8A.02 1207772 1209553 + ABC transporter SCG8A.02%2C probable ABC transporter%2C len: 593aa%3B similar to many eg. TR:CAB76002 (EMBL:AL157916) ABC transporter from Streptomyces coelicolor (583 aa) fasta scores%3B opt: 1624%2C z-score: 1736.4%2C E(): 0%2C 46.8%25 identity in 575 aa overlap. Contains Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region%2C Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible membrane-spanning hydrophobic regions. gene gene1134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1148 SCO1149 SCO1149 SCG8A.03 SCG8A.03 1209788 1210258 + hypothetical protein SCG8A.03%2C unknown%2C len: 156aa%3B strongly similar to another hypothetical protein from Streptomyces coelicolor TR:CAB69691 (EMBL:AL137165) (158 aa) fasta scores%3B opt: 570%2C z-score: 640.3%2C E(): 3.2e-28%2C 59.5%25 identity in 153 aa overlap. Hydrophilic gene gene1135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1149 SCO1150 SCO1150 rpmE2 rpmE2 1210322 1210594 + 50S ribosomal protein L31 RpmE2%3B there appears to be two types of ribosomal proteins L31 in bacterial genomes%3B some contain a CxxC motif while others do not%3B Bacillus subtilis has both types%3B the proteins in this cluster do not have the CXXC motif%3B RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth%3B expression of ytiA is controlled by a zinc-specific transcriptional repressor%3B RpmE contains one zinc ion and a CxxC motif is responsible for this binding%3B forms an RNP particle along with proteins L5%2C L18%2C and L25 and 5S rRNA%3B found crosslinked to L2 and L25 and EF-G%3B may be near the peptidyltransferase site of the 50S ribosome gene gene1136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1150 SCO1151 SCO1151 SCG8A.05c SCG8A.05c 1210615 1211409 - hypothetical protein SCG8A.05c%2C possible integral membrane protein%2C len: 90aa%3B contains possible membrane-spanning hydrophobic regions. gene gene1137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1151 SCO1152 SCO1152 SCG8A.06 SCG8A.06 1211504 1214068 + helicase SCG8A.06%2C possible helicase%2C len: 854 aa%3B similar in regions to many eg. TR:CAB59484 (EMBL:AL132648) helicase from Streptomyces coelicolor (950 aa) fasta scores%3B opt: 417%2C z-score: 463.2%2C E(): 2.3e-18%2C 26.5%25 identity in 755 aa overlap and SW:P47047 (MTR4_YEAST) ATP-dependent RNA helicase DOB1 from Saccharomyces cerevisiae (Baker's yeast) (1073 aa) fasta scores%3B opt: 335%2C z-score: 370.4%2C E(): 3.5e-13%2C 25.1%25 identity in 650 aa overlap. Contains Pfam match to entry PF00270 DEAD%2C DEAD/DEAH box helicase. gene gene1138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1152 SCO1153 SCO1153 SCG8A.07 SCG8A.07 1214088 1214954 + acyl-CoA thioesterase II SCG8A.07%2C tesB%2C acyl-CoA thioesterase II%2C len: 288 aa%3B similar to many e.g. SW:P23911 (TESB_ECOLI) TesB%2C acyl-CoA thioesterase II from Escherichia coli (285 aa) fasta scores%3B opt: 758%2C z-score: 852.2%2C E(): 0%2C 44.1%25 identity in 286 aa overlap and SCC105.04c from Streptomyces coelicolor (290 aa) fasta scores%3B opt: 1004%2C z-score: 1023.6%2C E(): 0%2C 57.0%25 identity in 291 aa overlap. gene gene1139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1153 SCO1154 SCO1154 SCG8A.08c SCG8A.08c 1214956 1215927 - hypothetical protein SCG8A.08c%2C unknown%2C len: 323aa gene gene1140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1154 SCO1155 SCO1155 SCG8A.09c SCG8A.09c 1216065 1216478 - hypothetical protein SCG8A.09c%2C conserved hypothetical protein%2C len: 137aa%3B strongly similar to many from Streptomyces coelicolor eg. TR:Q9X835 (EMBL:AL049727) hypothetical 14.4 kD protein (139 aa) fasta scores%3B opt: 366%2C z-score: 458.5%2C E(): 4.3e-18%2C 48.0%25 identity in 127 aa overlap. Also strongly similar to neighbouring CDS SCG8A.13c. Contains Pfam match to entry PF01860 DUF42%2C Protein of unknown function gene gene1141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1155 SCO1156 SCO1156 SCG8A.10 SCG8A.10 1216584 1217012 + hypothetical protein SCG8A.10%2C conserved hypothetical protein%2C len: 142aa%3B similar to many eg. TR:O52559 (EMBL:AF040570) hypothetical protein from Amycolatopsis mediterranei (166 aa) fasta scores%3B opt: 222%2C z-score: 288.8%2C E(): 1.2e-08%2C 31.6%25 identity in 136 aa overlap. gene gene1142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1156 SCO1157 SCO1157 cvnD3 cvnD3 1217041 1217655 - ATP/GTP binding protein SCG8A.11c%2C cvnD3%2C possible ATP/GTP binding protein (conserved)%2C len: 204aa%3B strongly similar to many from Streptomyces coelicolor eg. TR:O86519 (EMBL:AL031124) ATP/GTP binding protein (174 aa) fasta scores%3B opt: 695%2C z-score: 846.0%2C E(): 0%2C 61.3%25 identity in 168 aa overlap. Also similar to others eg. TR:O67698 (EMBL:AE000759) hypothetical protein from Aquifex aeolicus (186 aa) fasta scores%3B opt: 341%2C z-score: 420.7%2C E(): 5.5e-16%2C 37.1%25 identity in 175 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1157 SCO1158 SCO1158 cvnC3 cvnC3 1217724 1218137 - hypothetical protein SCG8A.12c%2C cvnC3%2C hypothetical protein%2C len: 137 aa%3B strongly similar to many from Streptomyces coelicolor eg. TR:O86523 (EMBL:AL031124) hypothetical protein (132 aa) fasta scores%3B opt: 284%2C z-score: 351.0%2C E(): 4.2e-12%2C 42.6%25 identity in 129 aa overlap gene gene1144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1158 SCO1159 SCO1159 cvnB3 cvnB3 1218156 1218593 - hypothetical protein SCG8A.13c%2C cvnB3%2C hypothetical protein%2C len: 145 aa%3B strongly similar to many from Streptomyces coelicolor e.g. TR:Q9X835 (EMBL:AL049727) hypothetical 14.4 kD protein (139 aa) fasta scores%3B opt: 412%2C z-score: 512.5%2C E(): 4.2e-21%2C 52.8%25 identity in 127 aa overlap. Also strongly similar to neighbouring CDS SCG8A.09c. Contains Pfam match to entry PF01860 DUF42%2C Protein of unknown function gene gene1145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1159 SCO1160 SCO1160 cvnA3 cvnA3 1218590 1221178 - hypothetical protein SCG8A.14c%2C cvnA3%2C possible membrane protein%2C len: 862 aa%3B similar to many from Streptomyces coelicolor e.g. TR:Q9X836 (EMBL:AL049727) large hypothetical protein (877 aa) fasta scores%3B opt: 1248%2C z-score: 1146.3%2C E(): 0%2C 34.7%25 identity in 836 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene1146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1160 SCO1161 SCO1161 SCG8A.15c SCG8A.15c 1221241 1221975 - hypothetical protein SCG8A.15c%2C probable integral membrane protein%2C len: 244aa%3B N-terminal region similar to that of TR:CAB76246 (EMBL:X82447) CoxC protein from Pseudomonas carboxydovorans (402 aa) fasta scores%3B opt: 387%2C z-score: 455.6%2C E(): 6.2e-18%2C 34.6%25 identity in 243 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene1147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1161 SCO1162 SCO1162 SCG8A.16 SCG8A.16 1222188 1222787 + methyltransferase SCG8A.16%2C possible methyltransferase%2C len: 199 aa%3B similar to TR:Q55214 (EMBL:L35154) aklanonic acid methyltransferase from Streptomyces sp. (220 aa) fasta scores%3B opt: 228%2C z-score: 264.1%2C E(): 2.9e-07%2C 34.1%25 identity in 123 aa overlap. gene gene1148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1162 SCO1163 SCO1163 SCG8A.17c SCG8A.17c 1223235 1224134 - hypothetical protein SCG8A.17c%2C unknown%2C len: 299 aa%3B region 230-290aa similar to region from several eg. TR:Q22551 (EMBL:U41746) T18H9.1 from Caenorhabditis elegans (586 aa) fasta scores%3B opt: 110%2C z-score: 134.9%2C E(): 4.5%2C 29.5%25 identity in 105 aa overlap and TR:P72390 (EMBL:U51332) hypothetical protein from Streptomyces coelicolor (122 aa) fasta scores%3B opt: 101%2C z-score: 134.5%2C E(): 4.8%2C 40.0%25 identity in 75 aa overlap. gene gene1149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1163 SCO1164 SCO1164 SCG8A.18 SCG8A.18 1224211 1224537 + hypothetical protein SCG8A.18%2C unknown%2C len: 108aa gene gene1150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1164 SCO1165 SCO1165 SCG8A.19 SCG8A.19 1224677 1225594 + hypothetical protein SCG8A.19%2C possible integral membrane protein%2C len: 305aa%3B Contains possible membrane-spanning hydrophobic regions. gene gene1151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1165 SCO1166 SCO1166 SCG8A.20c SCG8A.20c 1225651 1225983 - hypothetical protein SCG8A.20c%2C possible integral membrane protein%2C len: 110aa%3B Contains possible membrane-spanning hydrophobic region. gene gene1152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1166 SCO1167 SCO1167 2SCG11.01 2SCG11.01 1226297 1228969 + helicase 2SCG11.01%2C probable helicase (fragment)%2C len: >697 aa%3B similar to C-terminal region of TR:CAB60181 (EMBL:AL132824) Streptomyces coelicolor helicase SCAH10.27%2C 977 aa%3B fasta scores: opt: 2570 z-score: 2915.8 E(): 0%3B 65.9%25 identity in 698 aa overlap. Contains Pfam match to entry PF00176 SNF2_N%2C SNF2 and others N-terminal domain and to PF00271 helicase_C%2C Helicases conserved C-terminal domain~SCG8A.21%2C partial CDS%2C possible helicase%2C len: >223aa%3B similar to TR:CAB60181 (EMBL:AL132824) helicase from Streptomyces coelicolor (977 aa) fasta scores%3B opt: 601%2C z-score: 651.6%2C E(): 7.5e-29%2C 51.1%25 identity in 231 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene1153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1167 SCO1168 SCO1168 2SCG11.02 2SCG11.02 1228966 1230234 + hypothetical protein 2SCG11.02c%2C hypothetical protein%2C len: 422 aa%3B similar to C-terminal region of TR:CAB60182 (EMBL:AL132824) Streptomyces coelicolor hypothetical 81.9 kD protein SCAH10.28%2C 797 aa%3B fasta scores: opt: 1009 z-score: 960.4 E(): 0%3B 44.4%25 identity in 435 aa overlap gene gene1154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1168 SCO1169 SCO1169 2SCG11.03c 2SCG11.03c 1230329 1231492 - xylose isomerase catalyzes the interconversion of D-xylose to D-xylulose gene gene1155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1169 SCO1170 SCO1170 2SCG11.04 2SCG11.04 1231648 1233093 + xylulose kinase 2SCG11.04c%2C xylB%2C xylulose kinase (fragment)%2C len: >81 aa%3B identical to N-terminal region of SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) XylB%2C 481 aa~SCG11A.01%2C xylB%2C xylulose kinase%2C len: >432 aa%3B highly similar to SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) (xylulokinase) XylB%2C 481 aa%3B fasta scores: opt: 2553 z-score: 2795.9 E(): 0%3B 89.2%25 identity in 427 aa overlap. Contains match to Pfam entry PF00370 FGGY%2C FGGY family of carbohydrate kinases and two Prosite matches to entries PS00933 FGGY family of carbohydrate kinases signature and PS00445 FGGY family of carbohydrate kinases signature 2 gene gene1156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1170 SCO1171 SCO1171 SCG11A.02 SCG11A.02 1233319 1234527 + xylose repressor SCG11A.02%2C possible xylose repressor%2C len: 402 aa%3B similar to SW:XYLR_BACSU (EMBL:M27248) Bacillus subtilis xylose repressor xylR%2C 384 aa%3B fasta scores: opt: 612 z-score: 642.4 E(): 2.1e-28%3B 29.4%25 identity in 381 aa overlap. Contains match to Pfam entry PF00480 ROK%2C ROK family and a possible helix-turn-helix motif at residues 43..64 (+3.15 SD) gene gene1157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1171 SCO1172 SCO1172 SCG11A.03 SCG11A.03 1234835 1235440 + amidase SCG11A.03%2C probable amidase (hypothetical protein)%2C len: 201 aa%3B similar to SW:AMPD_ECOLI (EMBL:X15237) Escherichia coli anhydro-N-acetylmuramyl-tripeptide amidase AmpD%2C 183aa%3B fasta scores: opt: 211 z-score: 267.1 E(): 1.7e-07%3B 39.5%25 identity in 114 aa overlap and to Streptomyces coelicolor SC2A11.21c%3B fasta scores: opt: 674 z-score: 751.6 E(): 0%3B 50.0%25 identity in 202 aa overlap. Contains match to Pfam entry PF01510 Amidase_2%2C N-acetylmuramoyl-L-alanine amidase. Contains possible N-terminal region signal peptide sequence gene gene1158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1172 SCO1173 SCO1173 SCG11A.04 SCG11A.04 1235615 1236874 + transcriptional regulator SCG11A.04%2C possible transcriptional regulator%2C len: aa%3B similar to TR:O31551 (EMBL:Z99108) Bacillus subtilis transcriptional regulator AcoR%2C 605 aa%3B fasta scores: opt: 393 z-score: 446.5 E(): 1.7e-17%3B 34.7%25 identity in 199 aa overlap gene gene1159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1173 SCO1174 SCO1174 SCG11A.05 SCG11A.05 1237012 1238535 + aldehyde dehydrogenase SCG11A.05%2C thcA%2C aldehyde dehydrogenase%2C len:534 aa%3B highly similar to SW:THCA_RHOSN (EMBL:U17129) Rhodococcus sp. (strain NI86/21) EPTC-inducible aldehyde dehydrogenase (EC 1.2.1.3) ThcA%2C 505 aa%3B fasta scores: opt: 2639 z-score: 3078.6 E(): 0%3B 75.7%25 identity in 506 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase and two matches to Prostie entries PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site gene gene1160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1174 SCO1175 SCO1175 SCG11A.06c SCG11A.06c 1238595 1239002 - hypothetical protein SCG11A.06c%2C hypothetical protein%2C len: 153 aa%3B similar to C-terminus of TR:O52556 (EMBL:AF040570) Amycolatopsis mediterranei esterase%2C 310 aa%3B fasta scores: opt: 303 z-score: 372.1 E(): 2.4e-13%3B 45.1%25 identity in 113 aa overlap gene gene1161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1175 SCO1176 SCO1176 SCG11A.07c SCG11A.07c 1239663 1241453 - dihydroxy-acid dehydratase catalyzes the formation of 3-methyl-2-oxobutanoate from 2%2C3%2C-dihydroxy-3-methylbutanoate gene gene1162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1176 SCO1177 SCO1177 SCG11A.08 SCG11A.08 1241562 1242302 + gntR-famly transcriptional regulator SCG11A.08%2C probable gntR-famly transcriptional regulator%2C len: 246 aa%3B similar to SW:DGOR_ECOLI (EMBL:L10328) Escherichia coli galactone operon transcriptional repressor GdoR%2C 229 aa%3B fasta scores: opt: 409 z-score: 460.9 E(): 2.7e-18%3B 36.5%25 identity in 219 aa overlap and to TR:O50536 (EMBL:AJ003022) Streptomyces coelicolor sporulation transcription factor WhiH%2C 295 aa%3B fasta scores: opt: 370 z-score: 416.5 E(): 8e-16%3B 35.2%25 identity in 230 aa overlap. Contians match to Pfam entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and match to Prosite entry PS00043 Bacterial regulatory proteins%2C gntR family signature gene gene1163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1177 SCO1178 SCO1178 SCG11A.09c SCG11A.09c 1242334 1242783 - hypothetical protein SCG11A.09c%2C unknown%2C len: 149 aa gene gene1164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1178 SCO1179 SCO1179 SCG11A.10c SCG11A.10c 1242817 1243575 - hypothetical protein SCG11A.10c%2C hypothetical protein%2C len: 252 aa%3B similar to various hypothetical proteins%2C e.g. TR:P95287 (EMBL:Z84498) Mycobacterium tuberculosis hypothetical 28.6 KD protein MTCY09F9.37c%2C 257 aa%3B fasta scores: opt: 729 z-score: 872.2 E(): 0%3B 48.3%25 identity in 238 aa overlap gene gene1165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1179 SCO1180 SCO1180 SCG11A.11 SCG11A.11 1243639 1244799 + DNA polymerase III subunit beta SCG11A.11%2C probable DNA polymerase III beta chain%2C len: 386 aa%3B N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor transcriptional regulator SC7H1.32c%2C 196 aa%3B fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06%3B 37.2%25 identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III%2C beta chain (EC 2.7.7.7) DnaN%2C 399 aa%3B fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10%3B 30.7%25 identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and C-terminal region to Pfam entry PF00712 DNA_pol3_beta%2C DNA polymerase III beta subunit. Contains a possible helix-turn-helix motif at residues 21..42 (+2.82 SD) gene gene1166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1180 SCO1181 SCO1181 SCG11A.12 SCG11A.12 1244920 1245774 + hypothetical protein SCG11A.12%2C hypothetical protein%2C len:284 aa%3B similar to TR:CAB46974 (EMBL:AL096825) Streptomyces coelicolor hypothetical 31.8 KD protein SC6G3.02%2C 292 aa%3B fasta scores: opt: 864 z-score: 1038.3 E(): 0%3B 47.9%25 identity in 286 aa overlap and to TR:O52845 (EMBL:AJ223073) Bradyrhizobium japonicum phosphate regulatroy protein%2C PhoB%2C 235 aa%3B fasta scores: opt: 113 z-score: 142.6 E(): 1.4%3B 32.1%25 identity in 131 aa overlap gene gene1167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1181 SCO1182 SCO1182 SCG11A.13 SCG11A.13 1245771 1250951 + hypothetical protein SCG11A.13%2C hypothetical protein%2C len: 1726 aa%3B similar to TR:CAB46975 (EMBL:AL096825) Streptomyces coelicolor hypothetical 181.5 KD protein SC6G3.03%2C 1678 aa%3B fasta scores: opt: 690 z-score: 716.6 E(): 1.5e-32%3B 35.6%25 identity in 1800 aa overlap gene gene1168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1182 SCO1183 SCO1183 SCG11A.14 SCG11A.14 1251004 1252173 + hypothetical protein SCG11A.14%2C hypothetical protein%2C len:389 aa: similar to various hypothetical proteins%2C e.g. SW:YEHL_ECOLI (EMBL:U00007) Escherichia coli hypothetical 42.4 KD protein in MolR-BglX intergenic region%2C 384 aa%3B fasta scores: opt: 873 z-score: 979.4 E(): 0%3B 45.1%25 identity in 381 aa overlap gene gene1169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1183 SCO1184 SCO1184 SCG11A.15 SCG11A.15 1252179 1256141 + hypothetical protein SCG11A.15%2C hypothetical protein%2C len: 1320 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB46976 (EMBL:AL096825) Streptomyces coelicolor hypothetical 122.6 KD protein SC6G3.04%2C 1171 aa%3B fasta scores: opt: 1532 z-score: 1249.6 E(): 0%3B 50.6%25 identity in 1315 aa overlap and to SW:YEHP_ECOLI (EMBL:U00007) Escherichia coli hypothetical 42.1 KD protein in MolR-BglX intergenic region YehP%2C 378 aa%3B fasta scores: opt: 660 z-score: 547.5 E(): 4e-23%3B 37.5%25 identity in 379 aa overlap gene gene1170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1184 SCO1185 SCO1185 SCG11A.16 SCG11A.16 1256138 1258141 + hypothetical protein SCG11A.16%2C hypothetical protein%2C len: 667 aa%3B similar to TR:CAB46977 (EMBL:AL096825) Streptomyces coelicolor hypothetical 60.3 KD protein SC6G3.05%2C 588 aa%3B fasta scores: opt: 633 z-score: 462.0 E(): 2.3e-18%3B 40.4%25 identity in 680 aa overlap gene gene1171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1185 SCO1186 SCO1186 SCG11A.17 SCG11A.17 1258218 1259243 + LacI family transcriptional regulator SCG11A.17%2C probable lacI-family transcriptional regulator%2C len: 341 aa%3B similar to TR:CAB46346 (EMBL:AJ009798) Streptomyces reticuli regulatory protein CebR%2C 350 aa%3B fasta scores: opt: 1241 z-score: 1440.4 E(): 0%3B 57.9%25 identity in 347 aa overlap and to SW:PURR_ECOLI (EMBL:J04212) Escherichia coli purine nucleotide synthesis repressor PurR%2C 340 aa%3B fasta scores: opt: 587 z-score: 684.5 E(): 9.5e-31%3B 35.7%25 identity in 336 aa overlap and to Streptomyces coelicolor SC4G6.23%3B fasta scores: opt: 989 z-score: 952.6 E(): 0%3B 53.8%25 identity in 316 aa overlap. Contains matches to Pfam entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Contains also a possible helix-turn-helix motif at residues 10..31 (+6.13 SD) gene gene1172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1186 SCO1187 SCO1187 celB celB 1259461 1260606 + cellulase B SCG11A.18%2C celB%2C cellulase B precursor%2C len: 381 aa%3B identical to TR:Q54331 (EMBL:U04629) Streptomyces lividans cellulase precursor%2C celB%2C 381 aa and similar to SW:GUX_CELFI (EMBL:M15824) Cellulomonas fimi exoglucanase/xylanase precursor [includes: exoglucanase (EC 3.2.1.91) (exocellobiohydrolase) (1%2C4-beta-cellobiohydrolase) (beta-1%2C4- glycanase Cex)%3B endo-1%2C4-beta-xylanase B (EC 3.2.1.8) (xylanase B) Cex or XynB%2C 484 aa%3B fasta scores: opt: 422 z-score: 450.5 E(): 1e-17%3B 48.8%25 identity in 123 aa overlap. Contains two matches to Pfam entries PF01670 Glyco_hydro_12%2C Glycosyl hydrolase family 12 and PF00553 CBD_2%2C Cellulose binding domain and match to Prosite entry PS00561 Cellulose-binding domain%2C bacterial type. Contains also possible signal peptide sequence gene gene1173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1187 SCO1188 SCO1188 celS2 celS2 1260854 1261948 + cellulose binding protein SCG11A.19%2C celS2%2C cellulose binding protein len: 364 aa%3B highly similar to TR:AAD27623 (EMBL:AF126376) Streptomyces viridosporus cellulose binding protein CelS2%2C 358 aa%3B fasta scores: opt: 2109 z-score: 2160.9 E(): 0%3B 81.9%25 identity in 364 aa overlap and to SW:GUNA_MICBI Microbispora bispora endoglucanase A precursor (EC 3.2.1.4) (endo-1%2C4-beta-glucanase) (CELLULASE) CelA%2C 456 aa%3B fasta scores: opt: 350 z-score: 363.9 E(): 6.8e-13%3B 30.6%25 identity in 278 aa overlap. Contains match to Pfam entry PF00553 CBD_2%2C Cellulose binding domain. Contains also possible signal peptide sequence gene gene1174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1188 SCO1189 SCO1189 SCG11A.20 SCG11A.20 1262121 1262546 + hypothetical protein SCG11A.20%2C unknown%2C len: 141 aa gene gene1175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1189 SCO1190 SCO1190 SCG11A.21c SCG11A.21c 1262509 1264110 - export protein SCG11A.21c%2C probable export protein%2C len: 533 aa%3B similar to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA%2C 538 aa%3B fasta scores: opt: 1520 z-score: 1545.7 E(): 0%3B 45.7%25 identity in 523 aa overlap gene gene1176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1190 SCO1191 SCO1191 SCG11A.22c SCG11A.22c 1264183 1264656 - MarR family transcriptional regulator SCG11A.22c%2C possible marR-family transcriptional regulator%2C len: 157 aa%3B low similarity to TR:CAB48917 (EMBL:AL096837) Streptomyces coelicolor marR-family transcriptional regulator SCF43A.30c%2C 169 aa%3B fasta scores: opt: 125 z-score: 167.7 E(): 0.058%3B 30.6%25 identity in 147 aa overlap gene gene1177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1191 SCO1192 SCO1192 SCG11A.23 SCG11A.23 1264780 1265148 + hypothetical protein SCG11A.23%2C hypothetical protein%2C len:122 aa%3B similar to various hypothetical proteins%2C e.g. TR:O53744 (EMBL:AL021933) Mycobacterium tuberculosis hypothetical 17.2 KD protein MTV038.03%2C 163 aa%3B fasta scores: opt: 478 z-score: 600.7 E(): 4.4e-26%3B 66.7%25 identity in 111 aa overlap gene gene1178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1192 SCO1193 SCO1193 SCG11A.24c SCG11A.24c 1265170 1265739 - TetR family transcriptional regulator SCG11A.24c%2C probable tetR-family transcriptional regulator%2C len: 189 aa%3B similar to TR:CAB56380 (EMBL:AL118515) Streptomyces coelicolor probable tetR-family transcriptional regulator SCD17.03%2C 226 aa%3B fasta scores: opt: 233 z-score: 295.6 E(): 4.3e-09%3B 35.2%25 identity in 176 aa overlap. Contains match to Pfam entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene1179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1193 SCO1194 SCO1194 SCG11A.25 SCG11A.25 1265841 1267331 + export protein SCG11A.25%2C probable export protein%2C len: 496 aa%3B similar to TR:P72184 (EMBL:U51164) Propionibacterium freudenreichii membrane-bound transport protein HemX%2C 487 aa%3B fasta scores: opt: 1371 z-score: 1416.9 E(): 0%3B 47.0%25 identity in 474 aa overlap and to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii (Streptomyces alboniger) puromycin resistance protein Pur8%2C 503aa%3B fasta scores: opt: 576 z-score: 598.4 E(): 5.9e-26%3B 30.2%25 identity in 493 aa overlap gene gene1180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1194 SCO1195 SCO1195 SCG11A.26c SCG11A.26c 1267321 1267515 - hypothetical protein SCG11A.26c%2C membrane protein%2C len: 64 aa. Contains possible hydrophobic membrane spanning regions gene gene1181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1195 SCO1196 SCO1196 SCG11A.27c SCG11A.27c 1267630 1268493 - hypothetical protein SCG11A.27c%2C hypothetical protein%2C len: 287 aa. Contains possible N-terminal region signal peptide sequence gene gene1182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1196 SCO1197 SCO1197 SCG11A.28c SCG11A.28c 1268663 1269751 - acyl-CoA dehydrogenase SCG11A.28c%2C possible acyl-CoA dehydrogenase%2C len:362 aa%3B low similarity to TR:AAD44195 (EMBL:AF142581) Streptomyces coelicolor acyl-CoA dehydrogenase AcdH%2C 386 aa%3B fasta scores: opt: 266 z-score: 294.1 E(): 5.2e-09%3B 28.3%25 identity in 392 aa overlap and to SW:ACDS_CLOAB (EMBL:U17110) Clostridium acetobutylicum acyl-CoA dehydrogenase%2C short-chain specific (EC 1.3.99.2) (ScaD) (butyryl-CoA dehydrogenase) Bcd%2C 379 aa%3B fasta scores: opt: 231 z-score: 256.5 E(): 6.5e-07%3B 26.5%25 identity in 378 aa overlap. Contains two matches to Pfam entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene1183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1197 SCO1198 SCO1198 SCG11A.29c SCG11A.29c 1269748 1270929 - acyl-CoA dehydrogenase SCG11A.29c%2C probable acyl-CoA dehydrogenase%2C len:393 aa%3B similar to TR:Q54857 (EMBL:) Streptomyces purpurascens acyl-CoA dehydrogenase FamB (fragment)%2C 288 aa%3B fasta scores: opt: 1195 z-score: 1377.5 E(): 0%3B 83.2%25 identity in 208 aa overlap and to SW:ACD_MYCLE (EMBL:U00012) Mycobacterium leprae acyl-CoA dehydrogenase (EC 1.3.99.-) Acd or B1308_F1_34%2C 389 aa%3B fasta scores: opt: 386 z-score: 447.1 E(): 1.6e-17%3B 28.5%25 identity in 376 aa overlap. Contains two matches to Pfam entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene1184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1198 SCO1199 SCO1199 SCG11A.30c SCG11A.30c 1270926 1271906 - oxidoreductase SCG11A.30c%2C probable oxidoreductase%2C len: 326 aa%3B highly similar to TR:Q54856 (EMBL:X61931) Streptomyces purpurascens famA (FAS domain)%2C 230 aa%3B fasta scores: opt: 1015 z-score: 1089.1 E(): 0%3B 79.5%25 identity in 239 aa overlap and to SW:QOR_PSEAE (EMBL:X85015) Pseudomonas aeruginosa quinone oxidoreductase (EC 1.6.5.5) (NADH:quinone reductase) Qor%2C 325 aa%3B fasta scores: opt: 446 z-score: 482.5 E(): 1.7e-19%3B 34.1%25 identity in 323 aa overlap. Contains match to Pfam entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature gene gene1185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1199 SCO1200 SCO1200 SCG11A.31c SCG11A.31c 1271991 1272566 - regulatory protein SCG11A.31c%2C probable regulatory protein%2C len 191 aa%3B similar to TR:Q54855 (EMBL:X61931) Streptomyces purpurascens ORF1%2C 90 aa%3B fasta scores: opt: 560 z-score: 686.7 E(): 7.2e-31%3B 85.6%25 identity in 90 aa overlap and to TR:CAB39703 (EMBL:AL049485) Streptomyces coelicolor DNA-binding protein SC6A5.19%2C 204 aa%3B fasta scores: opt: 382 z-score: 468.0 E(): 1.1e-18%3B 39.2%25 identity in 176 aa overlap and to Streptomyces coelicolor SC6G4.21%2C fasta scores: opt: 717 z-score: 721.2 E(): 8e-35%3B 60.0%25 identity in 190 aa overlap. Contains match to Pfam entry PF01381 HTH_3%2C Helix-turn-helix and a predicted possible motif at residues 25..46 (+6.09 SD) gene gene1186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1200 SCO1201 SCO1201 2SCG58.01 2SCG58.01 1272644 1273609 + reductase 2SCG58.01%2C possible reductase (fragment)%2C len: >43 aa%3B C-terminal part of TR:Q9RJW9 (EMBL:AL133210) Streptomyces coelicolor reductase (fragment) SCF37.32%2C 311 aa~SCG11A.32%2C possible reductase%2C len: >310 aa%3B similar to TR:Q9Z9W3 (EMBL:AB011836) Bacillus sp. (strain C-125) alkyl hydroperoxide reductase large subunit (EC 1.6.99.3) AhpF%2C 305 aa%3B fasta scores: opt: 668 z-score: 747.2 E(): 0%3B 37.3%25 identity in 295 aa overlap and to SW:AHPF_PSEPU (EMBL:AB010689) Pseudomonas putida alkyl hydroperoxide reductase subunit F (EC 1.6.4.-) AhpF%2C 520 aa%3B fasta scores: opt: 338 z-score: 378.9 E(): 9.9e-14%3B 28.6%25 identity in 308 aa overlap gene gene1187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1201 SCO1202 SCO1202 ligB ligB 1273700 1275238 + ATP-dependent DNA ligase catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA gene gene1188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1202 SCO1203 SCO1203 2SCG58.03 2SCG58.03 1275235 1275696 + MutT-like protein 2SCG58.03%2C possible MutT-like protein%2C len: 153 aa%3B similar to TR:CAB88476 (EMBL:AL353816) Streptomyces coelicolor MutT-like protein SCD84.10c%2C 142 aa%3B fasta scores: opt: 135 z-score: 171.1 E(): 0.046%3B 33.3%25 identity in 129 aa overlap. Contains match to Prosite entry PS00893 mutT domain signature gene gene1189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1203 SCO1204 SCO1204 gabD1 gabD1 1275830 1277215 + succinic semialdehyde dehydrogenase NADP-dependent semialdehyde dehydrogenase%3B part of alternative pathway from alpha-ketoglutarate to succinate gene gene1190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1204 SCO1205 SCO1205 2SCG58.05 2SCG58.05 1277253 1277477 + hypothetical protein 2SCG58.05%2C unknown%2C len: 74 aa gene gene1191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1205 SCO1206 SCO1206 2SCG58.06 2SCG58.06 1277625 1278749 + 1%2C3%2C6%2C8-tetrahydroxynaphthalene synthase 2SCG58.06%2C possible polyketide synthase%2C len: 374 aa%3B highly similar to TR:Q54240 (EMBL:AB018074) Streptomyces griseus ORF-1 protein similar to chalcone synthase%2C 372 aa%3B fasta scores: opt: 1769 z-score: 1998.4 E(): 0%3B 70.4%25 identity in 361 aa overlap and to SW:CHSJ_PETHY (EMBL:X14597) Petunia hybrida chalcone synthase J (EC 2.3.1.74) ChsJ%2C 389 aa%3B fasta scores: opt: 412 z-score: 469.3 E(): 1.1e-18%3B 29.5%25 identity in 312 aa overlap. Contains Pfam match to entry PF00195 Chal_stil_synt%2C Chalcone and stilbene synthases gene gene1192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1206 SCO1207 SCO1207 2SCG58.07 2SCG58.07 1278746 1279960 + cytochrome P450 2SCG58.07%2C probable cytochrome P450%2C len: 404 aa%3B similar to SW:CPXF_STRGO (EMBL:M32239) Streptomyces griseolus cytochrome P450-Su2 (EC 1.14.-.-) SubC%2C 402 aa%3B fasta scores: opt: 791 z-score: 895.3 E(): 0%3B 37.1%25 identity in 412 aa overlap and to TR:CAB88975 (EMBL:AL353864) Streptomyces coelicolor cytochrome P450 SC8F11.24c%2C 407 aa%3B fasta scores: opt: 1736 z-score: 1959.5 E(): 0%3B 61.2%25 identity in 407 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 and match to Prosite entry PS00086 Cytochrome P450 cysteine heme-iron ligand signature gene gene1193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1207 SCO1208 SCO1208 2SCG58.08 2SCG58.08 1279957 1280490 + hypothetical protein 2SCG58.08%2C hypothetical protein%2C len: 177 aa%3B similar to TR:CAB92104 (EMBL:AL356334) Streptomyces coelicolor hypothetical 21.7 kD protein SCD69.03%2C 200 aa%3B fasta scores: opt: 195 z-score: 238.2 E(): 8.4e-06%3B 31.7%25 identity in 164 aa overlap gene gene1194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1208 SCO1209 SCO1209 2SCG58.09c 2SCG58.09c 1280487 1281713 - acyl-CoA dehydrogenase 2SCG58.09c%2C probable acyl-CoA dehydrogenase%2C len: 408 aa%3B similar to SW:ACDA_BACSU (EMBL:Z49782) Bacillus subtilis acyl-CoA dehydrogenase (EC 1.3.99.-) AcdA%2C 379 aa%3B fasta scores: opt: 512 z-score: 587.6 E(): 2.9e-25%3B 41.3%25 identity in 400 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and match to Prosite entry PS00073 Acyl-CoA dehydrogenases signature 2 gene gene1195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1209 SCO1210 SCO1210 2SCG58.10 2SCG58.10 1281884 1282540 + transcriptional regulator 2SCG58.10%2C probable transcriptional regulatory protein%2C len: 218 aa%3B similar to TR:O53757 (EMBL:AL021933) Mycobacterium tuberculosis regulatory protein MTV038.16c%2C 234 aa%3B fasta scores: opt: 214 z-score: 258.1 E(): 6.5e-07%3B 30.7%25 identity in 199 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 35..56 (+3.27 SD) gene gene1196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1210 SCO1211 SCO1211 2SCG58.11c 2SCG58.11c 1282582 1283235 - polypeptide deformylase 2SCG58.11c%2C probable polypeptide deformylase%2C len: 217 aa%3B similar to SW:DEF_STRCO (EMBL:AL078618) Streptomyces coelicolor polypeptide deformylase (EC 3.5.1.31) Def or SC10A7.23%2C 208 aa%3B fasta scores: opt: 594 z-score: 712.9 E(): 3.1e-32%3B 54.2%25 identity in 166 aa overlap and to SW:DEF_ECOLI (EMBL:X77800) Escherichia coli polypeptide deformylase (EC 3.5.1.31) Def%2C 168 aa%3B fasta scores: opt: 321 z-score: 391.3 E(): 2.5e-14%3B 34.2%25 identity in 155 aa overlap. Contains Pfam match to entry PF01327 Pep_deformylase%2C Polypeptide deformylase gene gene1197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1211 SCO1212 SCO1212 2SCG58.12 2SCG58.12 1283300 1284538 + ligase 2SCG58.12%2C possible ligase%2C len: 412 aa%3B similar to TR:Q9ZGG7 (EMBL:AF080002) Heliobacillus mobilis UDP-N-acetylmuramyl tripeptide synthetase MurC%2C 455 aa%3B fasta scores: opt: 261 z-score: 287.4 E(): 1.5e-08%3B 29.3%25 identity in 441 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase%2C Mur ligase family gene gene1198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1212 SCO1213 SCO1213 2SCG58.13 2SCG58.13 1284562 1285290 + hypothetical protein 2SCG58.13%2C hypotetical protein%2C len: 242 aa%3B similar to TR:Q9ZGG8 (EMBL:AF080002) Heliobacillus mobilis cobyric acid synthase CobQ%2C 252 aa%3B fasta scores: opt: 505 z-score: 574.8 E(): 1.5e-24%3B 39.5%25 identity in 238 aa overlap gene gene1199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1213 SCO1214 SCO1214 2SCG58.14 2SCG58.14 1285457 1286482 + 6-phosphofructokinase catalyzes the formation of D-fructose 1%2C6-bisphosphate from D-fructose 6-phosphate in glycolysis gene gene1200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1214 SCO1215 SCO1215 2SCG58.15 2SCG58.15 1286676 1287626 + hypothetical protein 2SCG58.15%2C possible integral membrane protein%2C len: 316 aa%3B similar to SW:CTAG_BACSU (EMBL:Z98682) Bacillus subtilis CtaG protein%2C 297 aa%3B fasta scores: opt: 139 z-score: 169.9 E(): 0.053%3B 24.7%25 identity in 292 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1215 SCO1216 SCO1216 2SCG58.16 2SCG58.16 1287637 1287840 + hypothetical protein 2SCG58.16%2C possible integral membrane protein%2C len: 67 aa. Contains possible hydrophobic membrane spanning regions gene gene1202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1216 SCO1217 SCO1217 2SCG58.17c 2SCG58.17c 1287879 1289096 - sensor kinase 2SCG58.17c%2C possible sensor kinase%2C len: 405 aa%3B similar to TR:AAF31453 (EMBL:AF221126) Streptococcus pneumoniae histidine kinase ZmpS%2C 563 aa%3B fasta scores: opt: 375 z-score: 453.5 E(): 8.6e-18%3B 26.7%25 identity in 363 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase and possible N-terminal region signal peptide sequence (possibly cleavable) gene gene1203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1217 SCO1218 SCO1218 2SCG58.18c 2SCG58.18c 1289093 1290928 - transmembrane transport protein 2SCG58.18c%2C possible transmembrane transport protein%2C len: 611 aa%3B similar to TR:Q9RX38 (EMBL:AE001907) Deinococcus radiodurans sodium:solute symporter protein DR0477%2C 528 aa%3B fasta scores: opt: 379 z-score: 407.0 E(): 3.3e-15%3B 30.5%25 identity in 564 aa overlap. Contains Pfam match to entry PF00474 SSF%2C Sodium:solute symporter family and match to Prosite entry PS00457 Sodium:solute symporter family signature 2. Also contains possible hydrophobic membrane spanning regions and 4x conserved repeat unit: RTDLL gene gene1204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1218 SCO1219 SCO1219 2SCG58.19c 2SCG58.19c 1290957 1291352 - hypothetical protein 2SCG58.19c%2C possible integral membrane protein%2C len: 131 aa. Contains possible hydrophobic membrane spanning regions gene gene1205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1219 SCO1220 SCO1220 2SCG58.20c 2SCG58.20c 1291356 1292117 - regulatory protein 2SCG58.20c%2C probable regulatory protein%2C len: 253 aa%3B similar to SW:ALGR_PSEAE (EMBL:M23230) Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR%2C 248 aa%3B fasta scores: opt: 384 z-score: 457.3 E(): 5.3e-18%3B 36.5%25 identity in 255 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain gene gene1206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1220 SCO1221 SCO1221 2SCG58.21 2SCG58.21 1292195 1292698 + transcription regulator AsnC 2SCG58.21%2C possible AsnC-family regulatory protein%2C len: 167 aa%3B similar to SW:PUTR_RHOCA (EMBL:X78346) Rhodobacter capsulatus proline dehydrogenase transcriptional activator PutR%2C 154 aa%3B fasta scores: opt: 248 z-score: 311.6 E(): 6.9e-10%3B 31.3%25 identity in 147 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family gene gene1207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1221 SCO1222 SCO1222 2SCG58.22 2SCG58.22 1292824 1293690 + hypothetical protein 2SCG58.22%2C conserved hypothetical protein%2C len: 288 aa%3B similar to TR:P71889 (EMBL:Z79702) Mycobacterium tuberculosis hypothetical 33.0 kD protein MTCY3G12.11%2C 302 aa%3B fasta scores: opt: 561 z-score: 623.2 E(): 3e-27%3B 47.0%25 identity in 279 aa overlap gene gene1208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1222 SCO1223 SCO1223 2SCG58.23 2SCG58.23 1293687 1294910 + ornithine aminotransferase 2SCG58.23%2C rocD%2C ornithine aminotransferase%2C len: 407 aa%3B highly similar to SW:OAT_BACSU (EMBL:X81802) Bacillus subtilis ornithine aminotransferase (EC 2.6.1.13) RocD%2C 401 aa%3B fasta scores: opt: 1356 z-score: 1462.1 E(): 0%3B 50.4%25 identity in 395 aa overlap. Contains Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site gene gene1209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1223 SCO1224 SCO1224 2SCG58.24c 2SCG58.24c 1294926 1295384 - sugar-phosphate isomerase 2SCG58.24c%2C possible sugar-phosphate isomerase%2C len: 152 aa%3B similar to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) RpiB%2C 149 aa%3B fasta scores: opt: 248 z-score: 314.7 E(): 4.6e-10%3B 36.6%25 identity in 134 aa overlap gene gene1210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1224 SCO1225 SCO1225 2SCG58.25 2SCG58.25 1295526 1297040 + osmoprotectant transporter 2SCG58.25%2C probable osmoprotectant transporter%2C len: 504 aa%3B similar to SW:PROP_ECOLI (EMBL:M83089) Escherichia coli proline/betaine transporter ProP%2C 500 aa%3B fasta scores: opt: 1534 z-score: 1728.8 E(): 0%3B 44.7%25 identity in 465 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and matches to Prosite entries PS00217 Sugar transport proteins signature 2 and PS00216 Sugar transport proteins signature 1. Also contains possible hydrophobic membrane spanning regions gene gene1211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1225 SCO1226 SCO1226 2SCG1.01c 2SCG1.01c 1297131 1300331 - hypothetical protein 2SCG1.01c%2C possible metallopeptidase (fragment)%2C len: >385 aa%3B similar to TR:CAB76001 (EMBL:AL157916) Streptomyces coelicolor neutral zinc metallopeptidase SC3D11.04c%2C 684 aa%3B fasta scores: opt: 504 z-score: 545.2 E(): 6.7e-23%3B 35.2%25 identity in 406 aa overlap. Contains match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Also contains possible N-terminal region signal peptide sequence~2SCG58.26c%2C possible bifunctional protein (fragment)%2C len: >713 aa%3B middle region highly similar to SW:APX_STRGR Streptomyces griseus aminopeptidase (EC 3.4.11.-) SgaP%2C 284 aa%3B fasta scores: opt: 967 z-score: 978.8 E(): 0%3B 51.1%25 identity in 284 aa overlap and C-terminal region similar to C-terminal region of SW:CHI1_BACCI (EMBL:M57601) Bacillus circulans chitinase A1 precursor (EC 3.2.1.14) ChiA1%2C 699 aa%3B fasta scores: opt: 283 z-score: 287.0 E(): 1.6e-08%3B 25.0%25 identity in 476 aa overlap gene gene1212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1226 SCO1227 SCO1227 2SCG1.02c 2SCG1.02c 1300601 1302070 - DNA-binding protein 2SCG1.02c%2C possible DNA-binding protein%2C len: 489 aa%3B similar to TR:CAB89011 (EMBL:AL353870) Streptomyces coelicolor hypothetical 50.9 kD protein SC6F7.03%2C 467 aa%3B fasta scores: opt: 177 z-score: 183.6 E(): 0.0092%3B 26.7%25 identity in 476 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 44..65 (+3.67 SD). Also contains a TTA leucine codon (159)%2C possible target for bldA regulation gene gene1213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1227 SCO1228 SCO1228 2SCG1.03 2SCG1.03 1302287 1303009 + acyltransferase 2SCG1.03%2C probable acyltransferase%2C len: 240 aa%3B similar to TR:CAB76086 (EMBL:AL157956) Streptomyces coelicolor acyltransferase SCL24.02%2C 223 aa%3B fasta scores: opt: 786 z-score: 912.9 E(): 0%3B 51.1%25 identity in 219 aa overlap and to TR:CAB51970 (EMBL:AL109661) Streptomyces coelicolor hypothetical protein SC6E10.16c%2C 262 aa%3B fasta scores: opt: 912 z-score: 945.5 E(): 0%3B 59.6%25 identity in 240 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase%2C Acyltransferase gene gene1214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1228 SCO1229 SCO1229 2SCG1.04 2SCG1.04 1303058 1304119 + reductase 2SCG1.04%2C possible reductase%2C len: 353 aa%3B similar to TR:CAB90862 (EMBL:AL355752) Streptomyces coelicolor reductase SC10B7.09%2C 366 aa%3B fasta scores: opt: 182 z-score: 207.8 E(): 0.00042%3B 31.9%25 identity in 295 aa overlap gene gene1215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1229 SCO1230 SCO1230 2SCG1.05c 2SCG1.05c 1304188 1305813 - tripeptidylaminopeptidase 2SCG1.05c%2C possible tripeptidylaminopeptidase%2C len: 541 aa%3B almost identical to TR:Q54410 (EMBL:L27466) Streptomyces lividans tripeptidylaminopeptidase precursor%2C 537 aa and to TR:CAA18977 (EMBL:AL023517) Streptomyces coelicolor protease SC1B5.03c%2C 543 aa%3B fasta scores: opt: 1804 z-score: 1664.4 E(): 0%3B 51.0%25 identity in 547 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and match to Prosite entry PS00120 Lipases%2C serine active site. Also contains possible N-terminal region signal peptide sequence gene gene1216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1230 SCO1231 SCO1231 2SCG1.06c 2SCG1.06c 1305967 1306731 - urease accessory protein 2SCG1.06c%2C ureD%2C urease accessory protein%2C len: 254 aa%3B similar to SW:URED_ECOLI (EMBL:L03307) Escherichia coli urease accessory protein UreD%2C 278 aa%3B fasta scores: opt: 139 z-score: 156.7 E(): 0.29%3B 28.9%25 identity in 166 aa overlap. Contains Pfam match to entry PF01774 UreD%2C UreD urease accessory protein gene gene1217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1231 SCO1232 SCO1232 2SCG1.07c 2SCG1.07c 1306728 1307405 - urease accessory protein 2SCG1.07c%2C ureG%2C urease accessory protein%2C len: 225 aa%3B similar to SW:UREG_MYCTU (EMBL:U33011) Mycobacterium tuberculosis urease accessory protein UreG%2C 224 aa%3B fasta scores: opt: 900 z-score: 1007.7 E(): 0%3B 65.6%25 identity in 218 aa overlap. Contains Pfam match to entry PF01495 HypB_UreG%2C HypB/UreG nucleotide-binding domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1232 SCO1233 SCO1233 2SCG1.08c 2SCG1.08c 1307571 1308245 - urease accessroy protein UreF 2SCG1.08c%2C ureF%2C urease accessory protein%2C len: 224 aa%3B similar to SW:UREF_MYCTU (EMBL:U33011) Mycobacterium tuberculosis urease accessory protein UreF%2C 211 aa%3B fasta scores: opt: 401 z-score: 448.6 E(): 1.6e-17%3B 38.8%25 identity in 224 aa overlap. Contains Pfam match to entry PF01730 UreF%2C UreF and match to Prosite entry PS00099 Thiolases active site gene gene1219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1233 SCO1234 SCO1234 ureC ureC 1308254 1309975 - urease subunit alpha ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide%3B in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa%3B the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits gene gene1220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1234 SCO1235 SCO1235 ureB ureB 1309968 1310279 - urease subunit beta ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide%3B in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa%3B the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta)%3B in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity%2C optimum growth%2C resistance to low-pH killing in-vitro and persistence in-vivo%2C while the other operon does not seem to be active gene gene1221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1235 SCO1236 SCO1236 ureA ureA 1310293 1310595 - urease subunit gamma UreA%2C with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide%3B nickel metalloenzyme%3B accessory proteins UreD%2C UreE%2C UreF%2C and UreG are necessary for assembly of the metallocenter gene gene1222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1236 SCO1237 SCO1237 2SCG1.12c 2SCG1.12c 1310820 1311104 - hypothetical protein 2SCG1.12c%2C hypothetical protein%2C len: 94 aa%3B similar to TR:O50462 (EMBL:AL021006) Mycobacterium tuberculosis hypothetical 9.8 kD protein MTV006.19c%2C 89 aa%3B fasta scores: opt: 141 z-score: 195.0 E(): 0.0021%3B 36.6%25 identity in 71 aa ovelap gene gene1223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1237 SCO1238 SCO1238 2SCG1.13 2SCG1.13 1311216 1311851 + ATP-dependent Clp protease 2SCG1.13%2C probable ATP-dependent Clp protease%2C len: 211 aa%3B similar to TR:Q9ZH58 (EMBL:AF071885) Streptomyces coelicolor ATP-dependent Clp protease proteolytic subunit 2 (EC 3.4.21.92) ClpP2%2C 236 aa%3B fasta scores: opt: 769 z-score: 885.2 E(): 0%3B 55.8%25 identity in 208 aa overlap. Contains Pfam match to entry PF00574 CLP_protease%2C Clp protease gene gene1224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1238 SCO1239 SCO1239 2SCG1.14 2SCG1.14 1311859 1312167 + hypothetical protein 2SCG1.14%2C unknown%2C len: 102 aa gene gene1225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1239 SCO1240 SCO1240 2SCG1.15 2SCG1.15 1312684 1313157 + hypothetical protein 2SCG1.15%2C possible hypothetical protein ( hypothetical protein)%2C len: 157 aa%3B similar to C-terminal region of TR:CAB92659 (EMBL:AL356832) Streptomyces coelicolor hypothetical protein SCD63A.07c%2C 398 aa%3B fasta scores: opt: 351 z-score: 415.4 E(): 1.1e-15%3B 42.5%25 identity in 134 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family. Contains possible N-terminal region signal peptide sequence gene gene1226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1240 SCO1241 SCO1241 2SCG1.16c 2SCG1.16c 1313128 1313640 - hypothetical protein 2SCG1.16c%2C conserved hypothetical protein%2C len: 170 aa%3B similar to TR:Q9X7Q5 (EMBL:AL049587) Streptomyces coelicolor hypothetical 17.1 kD protein%2C 161 aa%3B fasta scores: opt: 269 z-score: 295.6 E(): 5.3e-09%3B 39.4%25 identity in 132 aa overlap gene gene1227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1241 SCO1242 SCO1242 2SCG1.17 2SCG1.17 1313856 1314716 + DNA-binding protein 2SCG1.17%2C probable DNA-binding protein%2C len: 286 aa%3B similar to TR:CAB8844 (EMBL:AL353815) Streptomyces coelicolor DNA-binding protein SCD6.19%2C 295 aa%3B fasta scores: opt: 626 z-score: 747.0 E(): 0%3B 40.0%25 identity in 280 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 25..46 (+4.46 SD). Also contains a TTA leucine codon (58)%2C possible target for bldA regulation gene gene1228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1242 SCO1243 SCO1243 2SCG1.18c 2SCG1.18c 1315011 1316138 - 8-amino-7-oxononanoate synthase catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine gene gene1229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1243 SCO1244 SCO1244 2SCG1.19 2SCG1.19 1316289 1317512 + biotin synthase catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine gene gene1230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1244 SCO1245 SCO1245 2SCG1.20 2SCG1.20 1317505 1318791 + adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7%2C8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate gene gene1231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1245 SCO1246 SCO1246 bioD bioD 1318793 1319509 + dithiobiotin synthetase DTB synthetase%3B dethiobiotin synthase%3B involved in production of dethiobiotin from ATP and 7%2C8-diaminononanoate and carbon dioxide%3B contains magnesium gene gene1232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1246 SCO1247 SCO1247 2SCG1.22 2SCG1.22 1319887 1320564 + hypothetical protein 2SCG1.22%2C conserved hypothetical protein%2C len: 225 aa%3B similar to TR:O06547 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 23.4 kD protein MTCI65.14%2C 216 aa%3B fasta scores: opt: 500 z-score: 599.5 E(): 6.3e-26%3B 45.9%25 identity in 209 aa overlap gene gene1233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1247 SCO1248 SCO1248 2SCG1.23c 2SCG1.23c 1320586 1320960 - hypothetical protein 2SCG1.23c%2C conserved hypothetical protein%2C len: 124 aa%3B similar to TR:Q9RJS4 (EMBL:AL132707) Streptomyces coelicolor hypothetical 14.1 kD protein%2C 127 aa%3B fasta scores: opt: 214 z-score: 293.3 E(): 7.2e-09%3B 38.5%25 identity in 122 aa overlap gene gene1234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1248 SCO1249 SCO1249 2SCG1.24c 2SCG1.24c 1320980 1321207 - hypothetical protein 2SCG1.24c%2C unknown%2C len: 75 aa gene gene1235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1249 SCO1250 SCO1250 2SCG1.25 2SCG1.25 1321315 1321740 + acetyltransferase 2SCG1.25%2C possible acetyltransferase%2C len: 141 aa%3B similar to TR:CAB72694 (EMBL:AL139074) Campylobacter jejuni acetyltransferase CJ0225%2C 148 aa%3B fasta scores: opt: 187 z-score: 246.3 E(): 3e-06%3B 26.5%25 identity in 132 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1250 SCO1251 SCO1251 2SCG1.26 2SCG1.26 1321823 1323229 + hypothetical protein 2SCG1.26%2C possible integral membrane protein%2C len: 468 aa%3B similar to TR:Q9RKZ4 (EMBL:AL133213) Streptomyces coelicolor integral membrane protein SC6D7.03%2C 443 aa%3B fasta scores: opt: 1577 z-score: 1678.6 E(): 0%3B 59.3%25 identity in 427 aa overlap. Contains Pfam matches to entries PF01595 DUF21%2C Domain of unknown function DUF21 and 2x PF00571 CBS%2C CBS domain. Also contains possible N-terminal region signal peptide sequence (seems to be cleavable) and possible hydrophobic membrane spanning regions gene gene1237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1251 SCO1252 SCO1252 2SCG1.27 2SCG1.27 1323226 1324239 + hypothetical protein 2SCG1.27%2C possible integral membrane protein%2C len: 337 aa%3B similar to TR:Q9RKZ3 (EMBL:AL133213) Streptomyces coelicolor integral membrane protein SC6D7.04%2C 347 aa%3B fasta scores: opt: 1101 z-score: 1230.5 E(): 0%3B 50.7%25 identity in 337 aa overlap. Contains Pfam matches to entries PF01595 DUF21%2C Domain of unknown function DUF21 and 2x PF00571 CBS%2C CBS domain. Also contains possible N-terminal region signal peptide sequence (seems to be cleavable) and possible hydrophobic membrane spanning region gene gene1238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1252 SCO1253 SCO1253 2SCG1.28 2SCG1.28 1324336 1325118 + hypothetical protein 2SCG1.28%2C conserved hypothetical protein%2C len: 260 aa%3B similar to TR:Q9X7W9 (EMBL:AL049485) Streptomyces coelicolor hypothetical 28.1 kD protein SC6A5.23%2C 261 aa%3B fasta scores: opt: 646 z-score: 748.3 E(): 0%3B 44.0%25 identity in 250 aa overlap gene gene1239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1253 SCO1254 SCO1254 2SCG1.29 2SCG1.29 1325285 1326727 + adenylosuccinate lyase Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide gene gene1240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1254 SCO1255 SCO1255 2SCG18.02 2SCG18.02 1326802 1327284 + G/U mismatch-specific DNA glycosylase 2SCG18.02%2C mug%2C G/U mismatch-specific DNA glycosylase%2C len: 160 aa%3B highly similar to SW:MUG_ECOLI (EMBL:U28379) Escherichia coli mismatch-specific DNA glycosylase (EC 3.2.2.-) Mug%2C 168 aa%3B fasta scores: opt: 448 z-score: 564.7 E(): 5.7e-24%3B 44.7%25 identity in 152 aa overlap gene gene1241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1255 SCO1256 SCO1256 2SCG18.03c 2SCG18.03c 1327484 1327924 - hypothetical protein 2SCG18.03c%2C unknown%2C len: 146 aa gene gene1242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1256 SCO1257 SCO1257 2SCG18.04c 2SCG18.04c 1327991 1328716 - ABC transporter 2SCG18.04c%2C possible ABC transport system integral membrane protein%2C len: 241 aa%3B similar to TR:CAB94565 (EMBL:AL359152) Streptomyces coelicolor ABC transport system integral membrane protein 2SC6G5.38c%2C 258 aa%3B fasta scores: opt: 513 z-score: 578.5 E(): 9.7e-25%3B 39.8%25 identity in 256 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1257 SCO1258 SCO1258 2SCG18.05c 2SCG18.05c 1328719 1329639 - ABC transporter ATP-binding protein 2SCG18.05c%2C possible ABC transport system ATP-binding protein%2C len: 306 aa%3B similar to TR:CAB94566 (EMBL:AL359152) Streptomyces coelicolor ABC transporter ATP-binding protein 2SC6G5.39c%2C 346 aa%3B fasta scores: opt: 1018 z-score: 1166.6 E(): 0%3B 53.9%25 identity in 306 aa overlap and to SW:BCRA_BACLI (EMBL:L20573) Bacillus licheniformis bacitracin transport ATP-binding protein BcrA%2C 306 aa%3B fasta scores: opt: 594 z-score: 684.6 E(): 1.2e-30%3B 35.6%25 identity in 303 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene1244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1258 SCO1259 SCO1259 2SCG18.06 2SCG18.06 1329747 1330901 + two-component system sensor kinase 2SCG18.06%2C probable two-component system sensor kinase%2C len: 384 aa%3B similar to TR:Q9ZBU9 (EMBL:AL034446) Streptomyces coelicolor sensor kinase SC1A9.03%2C 388 aa%3B fasta scores: opt: 377 z-score: 409.6 E(): 2.5e-15%3B 32.5%25 identity in 381 aa overlap and to TR:Q9Z678 (EMBL:AF102271) Streptomyces coelicolor sensor-histidine kinase%2C 398 aa%3B fasta scores: opt: 454 z-score: 491.8 E(): 6.6e-20%3B 38.0%25 identity in 287 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1259 SCO1260 SCO1260 2SCG18.07 2SCG18.07 1330916 1331578 + two-component system response regulator 2SCG18.07%2C probable two-component system response regulator%2C len: 220 aa%3B similar to TR:CAB95289 (EMBL:AL359779) Streptomyces coelicolor two-component system response regulator SCG22.16c%2C 221 aa%3B fasta scores: opt: 756 z-score: 640.4 E(): 4.5e-30%3B 57.7%25 identity in 222 aa overlap and to TR:Q9Z677 (EMBL:AF102271) Streptomyces coelicolor response-regulator%2C 213 aa%3B fasta scores: opt: 610 z-score: 693.5 E(): 3.8e-31%3B 50.7%25 identity in 215 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains possible helix-turn-helix motif at residues 172..193 (+3.03 SD) gene gene1246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1260 SCO1261 SCO1261 2SCG18.08 2SCG18.08 1331678 1332832 + transcriptional regulator 2SCG18.08%2C probable transcriptional regulatory protein%2C len: 384 aa%3B similar to TR:Q9S2D8 (EMBL:AL110470) Streptomyces coelicolor transcriptional repressor protein SCF85.03%2C 385 aa%3B fasta scores: opt: 980 z-score: 1062.5 E(): 0%3B 44.2%25 identity in 380 aa overlap and to SW:XYLR_ANATH (EMBL:Z69782) Anaerocellum thermophilum xylose repressor XylR%2C 399 aa%3B fasta scores: opt: 376 z-score: 411.5 E(): 1.9e-15%3B 25.4%25 identity in 394 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and possible helix-turn-helix motif at residues 30..51 (+2.57 SD) gene gene1247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1261 SCO1262 SCO1262 2SCG18.09c 2SCG18.09c 1332872 1333633 - GntR family transcriptional regulator 2SCG18.09c%2C probable gntR-family transcriptional regulator%2C len: 253 aa%3B similar to TR:Q9RKT6 (EMBL:AL132824) Streptomyces coelicolor transcriptional regulator SCAH10.21%2C 245 aa%3B fasta scores: opt: 306 z-score: 352.0 E(): 4e-12%3B 32.0%25 identity in 241 aa overlap and to SW:FARR_ECOLI (EMBL:X15790) Escherichia coli fatty acyl responsive regulator (P30 protein) FarR%2C 240 aa%3B fasta scores: opt: 204 z-score: 238.2 E(): 8.7e-06%3B 26.2%25 identity in 233 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and possible helix-turn-helix motif at residues 36..57 (+3.93 SD) gene gene1248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1262 SCO1263 SCO1263 2SCG18.10c 2SCG18.10c 1333824 1334711 - ECF-sigma factor 2SCG18.10c%2C probable ECF-sigma factor%2C len: 295 aa%3B similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor sigma factor SCC57A.13c%2C 315 aa%3B fasta scores: opt: 887 z-score: 1027.2 E(): 0%3B 50.5%25 identity in 285 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene1249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1263 SCO1264 SCO1264 2SCG18.11 2SCG18.11 1334793 1335743 + hydrolase 2SCG18.11%2C probable hydrolase%2C len: 316 aa%3B similar to TR:CAB88827 (EMBL:AL353832) Streptomyces coelicolor hydrolase SCE6.23c%2C 294 aa%3B fasta scores: opt: 302 z-score: 345.4 E(): 9.3e-12%3B 31.5%25 identity in 276 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene1250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1264 SCO1265 SCO1265 2SCG18.12c 2SCG18.12c 1335695 1336564 - lipase 2SCG18.12c%2C probable lipase%2C len: 289 aa%3B similar to TR:Q59644 (EMBL:X99255) Propionibacterium acnes triacylglycerol lipase precursor (EC 3.1.1.3) GehA%2C 339 aa%3B fasta scores: opt: 423 z-score: 498.8 E(): 2.7e-20%3B 36.9%25 identity in 233 aa overlap and to TR:Q9S295 (EMBL:AL096849) Streptomyces coelicolor lipase SCI11.24c%2C 290 aa%3B fasta scores: opt: 682 z-score: 722.5 E(): 1.2e-34%3B 47.0%25 identity in 264 aa overlap. Contains Pfam match to entry PF01674 Lipase_2%2C Lipase gene gene1251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1265 SCO1266 SCO1266 2SCG18.13c 2SCG18.13c 1336608 1337876 - 3-oxoacyl-ACP synthase gene gene1252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1266 SCO1267 SCO1267 2SCG18.14c 2SCG18.14c 1337873 1338130 - acyl carrier protein gene gene1253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1267 SCO1268 SCO1268 2SCG18.15c 2SCG18.15c 1338248 1339366 - acyltransferase 2SCG18.15c%2C probable acyltransferase%2C len: 372 aa%3B similar to SW:ODO2_ECOLI (EMBL:J01619) Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB%2C 404 aa%3B fasta scores: opt: 281 z-score: 311.6 E(): 7.1e-10%3B 24.8%25 identity in 400 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl%2C Biotin-requiring enzymes and match to Prosite entry PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site gene gene1254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1268 SCO1269 SCO1269 2SCG18.16c 2SCG18.16c 1339363 1340376 - pyruvate dehydrogenase subunit beta 2SCG18.16c%2C probable pyruvate dehydrogenase beta subunit%2C len: 337 aa%3B similar to TR:Q9ZQY1 (EMBL:AF069910) Zea mays pyruvate dehydrogenase E1 beta subunit isoform 3 (EC 1.2.4.1) Pdh2%2C 374 aa%3B fasta scores: opt: 494 z-score: 584.2 E(): 4.7e-25%3B 30.3%25 identity in 337 aa overlap gene gene1255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1269 SCO1270 SCO1270 2SCG18.17c 2SCG18.17c 1340373 1341344 - pyruvate dehydrogenase subunit alpha 2SCG18.17c%2C probable pyruvate dehydrogenase alpha subunit%2C len: 323 aa%3B similar to TR:O69011 (EMBL:AF086791) Zymomonas mobilis pyruvate dehydrogenase alpha subunit PdhA%2C 353 aa%3B fasta scores: opt: 553 z-score: 643.8 E(): 2.3e-28%3B 33.4%25 identity in 314 aa overlap. Contains Pfam match to entry PF00676 E1_dehydrog%2C Dehydrogenase E1 component gene gene1256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1270 SCO1271 SCO1271 2SCG18.18c 2SCG18.18c 1341355 1342317 - 3-oxoacyl-ACP synthase gene gene1257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1271 SCO1272 SCO1272 2SCG18.19c 2SCG18.19c 1342317 1342589 - acyl carrier protein gene gene1258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1272 SCO1273 SCO1273 2SCG18.20c 2SCG18.20c 1342661 1343779 - reductase 2SCG18.20c%2C probable reductase%2C len: 372 aa%3B similar to C-terminal domain of SW:HETM_ANASP (EMBL:L22883) Anabaena sp. polyketide synthase HetM%2C 506 aa%3B fasta scores: opt: 333 z-score: 389.0 E(): 3.5e-14%3B 35.7%25 identity in 395 aa overlap and to Streptomyces coelicolor 2SCG18.32c%2C 373 aa%3B fasta scores: opt: 241 z-score: 242.2 E(): 6.9e-08%3B 27.0%25 identity in 330 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation gene gene1259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1273 SCO1274 SCO1274 2SCG18.21 2SCG18.21 1344147 1344806 + hypothetical protein 2SCG18.21%2C unknown%2C len: 219 aa gene gene1260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1274 SCO1275 SCO1275 2SCG18.22 2SCG18.22 1344856 1346613 + halogenase 2SCG18.22%2C probable halogenase%2C len: 585 aa%3B similar to TR:P95482 (EMBL:U74493) Pseudomonas fluorescens halogenase PrnC%2C 567 aa %3Bfasta scores: opt: 1486 z-score: 1773.6 E(): 0%3B 40.9%25 identity in 541 aa overlap gene gene1261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1275 SCO1276 SCO1276 2SCG18.23 2SCG18.23 1346693 1347289 + RNA polymerase ECF sigma factor 2SCG18.23%2C sigJ%2C RNA polymerase ECF sigma factor%2C len: 198 aa%3B identical to previously sequenced TR:AAF35371 (EMBL:AF225460) Streptomyces coelicolor RNA polymerase ECF sigma factor SigJ%2C 198 aa. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene1262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1276 SCO1277 SCO1277 2SCG18.24 2SCG18.24 1347343 1348086 + hypothetical protein 2SCG18.24%2C unknown%2C len: 247 aa%3B identical to N-terminal region of TR:AAF35372 (EMBL:AF225460) Streptomyces coelicolor hypothetical 7.4 kD protein (fragment)%2C 72 aa%3B fasta scores: opt: 452 z-score: 395.3 E(): 1.6e-14%3B 94.4%25 identity in 72 aa overlap. Contains 4 sets of different repeats: 2x conserved repeat: SGSSR%2C 6x degenerate repeat: NPLA(A/G)%2C 7x degenerate repeat: G(A/G)A(G/Q/N) and 7x degenerate repeat: Q(G/V/L)(L/T) gene gene1263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1277 SCO1278 SCO1278 2SCG18.25 2SCG18.25 1348179 1349756 + ATP/GTP-binding protein 2SCG18.25%2C possible ATP/GTP-binding protein%2C len: 525 aa%3B similar to TR:O27682 (EMBL:AE000923) Methanobacterium thermoautotrophicum ABC transporter MTH1645%2C 561 aa%3B fasta scores: opt: 540 z-score: 600.5 E(): 5.8e-26%3B 30.1%25 identity in 372 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1278 SCO1279 SCO1279 2SCG18.26 2SCG18.26 1349799 1350677 + hypothetical protein 2SCG18.26%2C possible hypothetical protein%2C len: 292 aa%3B similar to TR:O07736 (EMBL:Z97193) Mycobacterium tuberculosis hypothetical 33.3 kD protein MTCY180.22%2C 303 aa%3B fasta scores: opt: 420 z-score: 478.9 E(): 3.4e-19%3B 36.8%25 identity in 247 aa overlap. Contains possible N-terminal signal peptide sequence gene gene1265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1279 SCO1280 SCO1280 2SCG18.27c 2SCG18.27c 1350735 1351976 - hypothetical protein 2SCG18.27c%2C conserved hypothetical protein%2C len: 413 aa%3B similar to TR:Q9S203 (EMBL:AL109747) Streptomyces coelicolor hypothetical 48.6 kD protein SCJ21.04c%2C 448 aa%3B fasta scores: opt: 360 z-score: 403.3 E(): 5.6e-15%3B 30.7%25 identity in 391 aa overlap gene gene1266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1280 SCO1281 SCO1281 2SCG18.28c 2SCG18.28c 1352088 1353410 - oxidoreductase 2SCG18.28c%2C possible oxidoreductase%2C len: 440 aa%3B similar to SW:ORDL_ECOLI (EMBL:U38543) Escherichia coli probable oxidoreductase OrdL%2C 426 aa%3B fasta scores: opt: 273 z-score: 283.9 E(): 2.5e-08%3B 27.7%25 identity in 433 aa overlap gene gene1267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1281 SCO1282 SCO1282 2SCG18.29c 2SCG18.29c 1353407 1353985 - oxidoreductase 2SCG18.29c%2C probable oxidoreductase%2C len: 192 aa%3B similar to TR:Q9ZA25 (EMBL:AJ011500) Streptomyces violaceoruber FMN:NADH oxidoreductase Gra-ORF34%2C 179 aa%3B fasta scores: opt: 320 z-score: 377.4 E(): 1.5e-13%3B 41.3%25 identity in 167 aa overlap. Contains Pfam match to entry PF01613 Flavin_Reduct%2C Flavin reductase like domain gene gene1268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1282 SCO1283 SCO1283 2SCG18.30c 2SCG18.30c 1353978 1354445 - hypothetical protein 2SCG18.30c%2C hypothetical protein%2C len: 155 aa%3B low similarity to N-terminal region of TR:Q53669 (EMBL:X89899) Streptomyces argillaceus mithramycin poliketide synthase MtmQ%2C 315 aa%3B fasta scores: opt: 130 z-score: 171.4 E(): 0.046%3B 27.5%25 identity in 120 aa overlap gene gene1269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1283 SCO1284 SCO1284 2SCG18.31c 2SCG18.31c 1354527 1355912 - aminotransferase 2SCG18.31c%2C probable aminotransferase (hypothetical protein)%2C len: 461 aa%3B similar to TR:CAB76097 (EMBL:AL157956) Streptomyces coelicolor acetonitrile amonitransferase ArgD%2C 402 aa%3B fasta scores: opt: 783 z-score: 776.7 E(): 0%3B 41.6%25 identity in 385 aa overlap and to SW:OAT_BACSU (EMBL:X81802) Bacillus subtilis ornithine amonitransferase (EC 2.6.1.13) RocD%2C 401 aa%3B fasta scores: opt: 692 z-score: 687.5 E(): 8.3e-31%3B 32.4%25 identity in 380 aa overlap. Contains Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Also contains a 6x degenerate repeat unit: (P/A/G)ST at N-terminal region and possible N-terminal region signal peptide sequence gene gene1270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1284 SCO1285 SCO1285 2SCG18.32c 2SCG18.32c 1355909 1357030 - ketoreductase 2SCG18.32c%2C possible ketoreductase%2C len: 373 aa%3B similar to N-terminal region of TR:O50417 (EMBL:AL009198) Mycobacterium tuberculosis multi-functional enzyme MTV004.49%2C 650 aa%3B fasta scores: opt: 215 z-score: 237.4 E(): 9.7e-06%3B 30.5%25 identity in 377 aa overlap and to TR:Q9XC69 (EMBL:AF147704) Streptomyces fradiae MDP-hexose 4-ketoreductase TylCIV%2C 347 aa%3B fasta scores: opt: 182 z-score: 205.6 E(): 0.00057%3B 26.8%25 identity in 291 aa overlap and to Streptomyces coelicolor 2SCG18.20%2C 372 aa%3B fasta scores: opt: 241 z-score: 231.1 E(): 2.8e-07%3B 27.0%25 identity in 330 aa overlap gene gene1271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1285 SCO1286 SCO1286 2SCG18.33c 2SCG18.33c 1357085 1358209 - oxidoreductase 2SCG18.33%2C probable oxidoreductase%2C len: 374 aa%3B similar to TR:P96072 (EMBL:U76606) Streptomyces viridifaciens isobutylamine N-hydroxylase (EC 1.14.-.-) (IBAH) VlmH%2C 378 aa%3B fasta scores: opt: 1020 z-score: 1177.8 E(): 0%3B 45.9%25 identity in 379 aa overlap gene gene1272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1286 SCO1287 SCO1287 2SCG18.34c 2SCG18.34c 1358281 1359243 - hypothetical protein 2SCG18.34c%2C hypothetical protein%2C len: 320 aa%3B similar to C-terminal region of TR:O31566 (EMBL:Z99108) Bacillus subtilis YfiX protein%2C 606 aa%3B fasta scores: opt: 252 z-score: 295.6 E(): 5.6e-09%3B 27.5%25 identity in 306 aa overlap gene gene1273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1287 SCO1288 SCO1288 2SCG18.35c 2SCG18.35c 1359227 1359733 - hypothetical protein 2SCG18.35c%2C possible integral membrane protein%2C len: 168 aa. Contains possible hydrophobic membrane spanning regions gene gene1274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1288 SCO1289 SCO1289 2SCG18.36 2SCG18.36 1359896 1361419 + GntR family transcriptional regulator 2SCG18.36%2C probable gntR-family regulatory protein%2C len: 507 aa%3B similar to TR:CAB89055 (EMBL:AL353872) Streptomyces coelicolor gntR-family regulator SC5G8.04%2C 462 aa%3B fasta scores: opt: 1289 z-score: 1152.7 E(): 0%3B 49.3%25 identity in 436 aa overlap and to SW:MOCR_RHIME (EMBL:X78503) Rhizobium meliloti probable rhizopine catabolism regulatory protein MocR%2C 493 aa%3B fasta scores: opt: 584 z-score: 527.8 E(): 6.5e-22%3B 34.8%25 identity in 451 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene1275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1289 SCO1290 SCO1290 2SCG18.36 2SCG18.36 1361564 1363153 + alkaline phosphatase SCBAC36F5.01%2C possible phosphatase (fragment)%2C len: >296 aa%3B similar to C-terminal region of SW:PPBD_BACSU (EMBL:U49060) Bacillus subtilis alkaline phosphatase D precursor (EC 3.1.3.1) PhoD%2C 556 aa%3B fasta scores: opt: 277 Z-score: 319.4 bits: 68.0 E(): 3.5e-10%3B 30.258%25 identity in 271 aa overlap~2SCG18.37%2C possible alkaline phosphatase (fragment)%2C len: >266 aa%3B similar to SW:PPBD_BACSU (EMBL:U49060) Bacillus subtilis alkaline phosphatase D precursor (EC 3.1.3.1) PhoD%2C 556 aa%3B fasta scores: opt: 148 z-score: 173.1 E(): 0.037%3B 25.2%25 identity in 270 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1290 SCO1291 SCO1291 SCBAC36F5.02 SCBAC36F5.02 1363304 1364707 + hypothetical protein SCBAC36F5.02%2C unknown%2C len: 467 aa gene gene1277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1291 SCO1292 SCO1292 SCBAC36F5.03 SCBAC36F5.03 1364716 1367439 + hypothetical protein SCBAC36F5.03%2C hypothetical protein%2C len: 907 aa. Contains possible N-terminal region signal peptide sequence gene gene1278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1292 SCO1293 SCO1293 SCBAC36F5.04 SCBAC36F5.04 1367555 1368913 + hypothetical protein SCBAC36F5.04%2C hypothetical protein%2C len: 452 aa%3B C-terminal part similar to TR:Q9FC64 (EMBL:AL391515) Streptomyces coelicolor acetyltransferase SC4B10.23%2C 163 aa%3B fasta scores: opt: 287 Z-score: 300.0 bits: 63.3 E(): 4.2e-09%3B 42.857%25 identity in 133 aa overlap. Contains Pfam match to entry PF01842 ACT%2C ACT domain and PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1293 SCO1294 SCO1294 SCBAC36F5.05c SCBAC36F5.05c 1368938 1370161 - cystathionine gamma-synthase SCBAC36F5.05c%2C possible cystathionine gamma-synthase%2C len: 407 aa%3B similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086%2C 369 aa%3B fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30%3B 34.127%25 identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP%2C Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2 gene gene1280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1294 SCO1295 SCO1295 SCBAC36F5.06 SCBAC36F5.06 1370221 1370712 + transcription regulator AsnC SCBAC36F5.06%2C probable AsnC-family transcriptional regulatory protein%2C len: 163 aa%3B similar to SW:LRP_RHIME (EMBL:AF193023) Rhizobium meliloti leucine-responsive regulatory protein Lrp%2C 156 aa%3B fasta scores: opt: 285 Z-score: 357.6 bits: 72.4 E(): 2.6e-12%3B 33.333%25 identity in 147 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and possible helix-turn-helix motif at residues 24..45 (+2.96 SD) gene gene1281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1295 SCO1296 SCO1296 SCBAC36F5.07 SCBAC36F5.07 1370791 1372479 + hypothetical protein SCBAC36F5.07%2C conserved hypothetical protein%2C len: 562 aa%3B similar to TR:Q9A3Z7 (EMBL:AE005968) Caulobacter crescentus hypothetical protein CC3053%2C 597 aa%3B fasta scores: opt: 331 Z-score: 361.3 bits: 76.8 E(): 1.6e-12%3B 28.308%25 identity in 597 aa overlap gene gene1282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1296 SCO1297 SCO1297 SCBAC36F5.08c SCBAC36F5.08c 1372948 1373469 - hypothetical protein SCBAC36F5.08c%2C unknown%2C len: 173 aa gene gene1283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1297 SCO1298 SCO1298 SCBAC36F5.09c SCBAC36F5.09c 1373491 1374042 - hypothetical protein SCBAC36F5.09c%2C conserved hypothetical protein%2C len: 183 aa%3B similar to TR:Q9KB42 (EMBL:AP001514) Bacillus halodurans BH2092 protein%2C 162 aa%3B fasta scores: opt: 361 Z-score: 424.4 bits: 85.0 E(): 5e-16%3B 37.410%25 identity in 139 aa overlap. Contains Pfam match to entry PF00581 Rhodanese%2C Rhodanese-like domain gene gene1284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1298 SCO1299 SCO1299 SCBAC36F5.10 SCBAC36F5.10 1374103 1374549 + transcriptional regulator SCBAC36F5.10%2C probable transcriptional regulatory protein%2C len: 148 aa%3B similar to SW:LRPC_BACSU (EMBL:AB001488) Bacillus subtilis transcriptional regulator LrpC%2C 144 aa%3B fasta scores: opt: 294 Z-score: 365.8 bits: 73.6 E(): 9.1e-13%3B 34.848%25 identity in 132 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and possible helix-turn-helix motif at residues 23..44 (+3.08 SD) gene gene1285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1299 SCO1300 SCO1300 SCBAC36F5.11c SCBAC36F5.11c 1374583 1377582 - exonuclease SCBAC36F5.11c%2C possible exonuclease%2C len: 999 aa%3B similar to SW:SBCC_ECOLI (EMBL:X15981) Escherichia coli exonuclease SbcC or B0397%2C 1048 aa%3B fasta scores: opt: 363 Z-score: 323.3 bits: 71.4 E(): 2.1e-10%3B 26.004%25 identity in 1096 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and a possible coiled-coil region at approx. residues 650..698 gene gene1286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1300 SCO1301 SCO1301 SCBAC36F5.12c SCBAC36F5.12c 1377579 1378742 - exonuclease SCBAC36F5.12c%2C possible exonuclease%2C len: 387 aa%3B similar to SW:SBCD_ECOLI (EMBL:X15981) Escherichia coli exonuclease SbcD or B0398%2C 400 aa%3B fasta scores: opt: 394 Z-score: 436.1 bits: 89.5 E(): 1.1e-16%3B 30.711%25 identity in 394 aa overlap. Contains Pfam match to entry PF02549 DNA_repair%2C DNA repair exonuclease gene gene1287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1301 SCO1302 SCO1302 SCBAC36F5.13c SCBAC36F5.13c 1379126 1379752 - hypothetical protein SCBAC36F5.13c%2C conserved hypothetical protein%2C len: 208 aa%3B similar to TR:Q9K6U5 (EMBL:AP001519) Bacillus halodurans BH3630 protein%2C 213 aa%3B fasta scores: opt: 659 Z-score: 773.5 bits: 150.1 E(): 1.8e-35%3B 46.341%25 identity in 205 aa overlap. Contains Pfam match to entry PF01205 UPF0029%2C Uncharacterized protein family UPF0029 and match to Prosite entry PS00910 Uncharacterized protein family UPF0029 signature gene gene1288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1302 SCO1303 SCO1303 SCBAC36F5.14c SCBAC36F5.14c 1379824 1380627 - hypothetical protein SCBAC36F5.14c%2C unknown%2C len: 267 aa gene gene1289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1303 SCO1304 SCO1304 SCBAC36F5.15 SCBAC36F5.15 1380724 1381131 + hypothetical protein SCBAC36F5.15%2C conserved hypothetical protein%2C len: 135 aa%3B similar to TR:BAB34472 (EMBL:AP002554) Escherichia coli O157:H7 hypothetical 14.7 kDa protein ECS1049%2C 137 aa%3B fasta scores: opt: 401 Z-score: 483.6 bits: 95.2 E(): 2.5e-19%3B 50.376%25 identity in 133 aa overlap. Contains Pfam match to entry PF02629 DUF184%2C Uncharacterized ACR%2C COG1832 gene gene1290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1304 SCO1305 SCO1305 SCBAC36F5.16c SCBAC36F5.16c 1381144 1382538 - hypothetical protein SCBAC36F5.16c%2C conserved hypothetical protein%2C len: 464 aa%3B low similarity to SW:Y929_THEMA (EMBL:U24145) Thermotoga maritima hypothetical protein TM0929%2C 397 aa%3B fasta scores: opt: 253 Z-score: 253.9 bits: 56.1 E(): 1.6e-06%3B 25.789%25 identity in 380 aa overlap. Contains match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature and a 6x degenerate repeat: KP(P/M) gene gene1291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1305 SCO1306 SCO1306 SCBAC36F5.17c SCBAC36F5.17c 1382544 1383788 - hypothetical protein SCBAC36F5.17c%2C conserved hypothetical protein%2C len: 414 aa%3B low similarity to TR:Q9RV59 (EMBL:AE001966) Deinococcus radiodurans conserved hypothetical protein DR1171%2C 340 aa%3B fasta scores: opt: 365 Z-score: 391.7 bits: 81.2 E(): 3.3e-14%3B 34.637%25 identity in 358 aa overlap gene gene1292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1306 SCO1307 SCO1307 SCBAC36F5.18c SCBAC36F5.18c 1383886 1385292 - hypothetical protein SCBAC36F5.18c%2C unknown%2C len: 468 aa gene gene1293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1307 SCO1308 SCO1308 SCBAC36F5.19 SCBAC36F5.19 1385454 1386677 + 4-hydroxybenzoate 3-monooxygenase catalyzes the formation of protocatechuate from 4-hydroxybenzoate gene gene1294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1308 SCO1309 SCO1309 SCBAC36F5.20c SCBAC36F5.20c 1386707 1387054 - regulatory protein SCBAC36F5.20c%2C possible regulatory protein%2C len: 115 aa%3B similar to TR:O53838 (EMBL:AL022004) Mycobacterium tuberculosis transcriptional regulator RV0827c or MTV043.19c%2C 130 aa%3B fasta scores: opt: 243 Z-score: 311.9 bits: 63.2 E(): 9.2e-10%3B 39.252%25 identity in 107 aa overlap gene gene1295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1309 SCO1310 SCO1310 SCBAC36F5.21 SCBAC36F5.21 1387179 1388270 + cation efflux system protein SCBAC36F5.21%2C possible cation efflux system protein%2C len: 363 aa%3B similar to TR:AAK46363 (EMBL:AE007059) Mycobacterium tuberculosis CDC1551 MT2084%2C 332 aa%3B fasta scores: opt: 1199 Z-score: 1252.9 bits: 240.3 E(): 3.6e-62%3B 59.627%25 identity in 322 aa overlap. Contains Pfam match to entry PF01545 Cation_efflux%2C Cation efflux family and possible hydrophobic membrane spanning regions gene gene1296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1310 SCO1311 SCO1311 SCBAC36F5.22c SCBAC36F5.22c 1388275 1388832 - hypothetical protein SCBAC36F5.22c%2C conserved hypothetical protein%2C len: 185 aa%3B similar to TR:Q9I1H4 (EMBL:AE004656) Pseudomonas aeruginosa hypothetical protein PA2301%2C 180 aa%3B fasta scores: opt: 386 Z-score: 464.0 bits: 92.5 E(): 3.1e-18%3B 44.118%25 identity in 170 aa overlap gene gene1297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1311 SCO1312 SCO1312 SCBAC36F5.23c SCBAC36F5.23c 1388876 1389481 - transcriptional regulator SCBAC36F5.23c%2C probable transcriptional regulatory protein%2C len: 201 aa%3B similar to TR:Q9I1G3 (EMBL:AE004657) Pseudomonas aeruginosa probable transcriptional regulator PA2312%2C 193 aa%3B fasta scores: opt: 339 Z-score: 397.1 bits: 80.3 E(): 1.6e-14%3B 35.519%25 identity in 183 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and two possible helix-turn-helix domains at residues 35..56 (+2.92 SD) and 64..85 (+4.24 SD) gene gene1298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1312 SCO1313 SCO1313 SCBAC36F5.24 SCBAC36F5.24 1389568 1390425 + hypothetical protein SCBAC36F5.24%2C possible integral membrane protein%2C len: 285 aa%3B similar to TR:Q9RRQ1 (EMBL:AE002073) Deinococcus radiodurans hypothetical 27.6 kDa protein DR2437%2C 278 aa%3B fasta scores: opt: 307 Z-score: 316.3 bits: 66.4 E(): 5.2e-10%3B 35.052%25 identity in 291 aa overlap. Contains 2x Pfam matches to entry PF00892 DUF6%2C Integral membrane protein DUF6 and possible hydrophobic membrane spanning regions gene gene1299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1313 SCO1314 SCO1314 SCBAC36F5.25c SCBAC36F5.25c 1390456 1391259 - sugar acetyltransferase SCBAC36F5.25c%2C possible sugar acetyltransferase%2C len: 267 aa%3B middle region similar to SW:MAA_ECOLI (EMBL:) Escherichia coli maltose O-acetyltransferase (EC 2.3.1.79) Maa or B0459%2C 182 aa%3B fasta scores: opt: 264 Z-score: 295.9 bits: 61.9 E(): 7.2e-09%3B 36.735%25 identity in 147 aa overlap. Contains 5x Pfam matches to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) gene gene1300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1314 SCO1315 SCO1315 SCBAC36F5.26 SCBAC36F5.26 1391367 1391903 + siderophore binding protein SCBAC36F5.26%2C possible siderophore binding protein%2C len: 178 aa%3B similar to TR:Q9V158 (EMBL:AJ248284) Pyrococcus abyssi ferripyochelin binding protein Fbp or PAB0393%2C 173 aa%3B fasta scores: opt: 525 Z-score: 583.9 bits: 114.5 E(): 6.5e-25%3B 49.068%25 identity in 161 aa overlap. Contains 4x Pfam matches to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) gene gene1301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1315 SCO1316 SCO1316 SCBAC36F5.27c SCBAC36F5.27c 1391967 1392602 - hypothetical protein SCBAC36F5.27c%2C possible integral membrane protein%2C len: 211 aa%3B similar to SW:YQ37_MYCTU (EMBL:Z80225) Mycobacterium tuberculosis hypothetical 23.0 kDa protein RV2637%2C 218 aa%3B fasta scores: opt: 833 Z-score: 928.0 bits: 178.8 E(): 4.4e-44%3B 58.706%25 identity in 201 aa overlap. Contains Pfam match to entry PF00597 DedA%2C DedA family and match to Prosite entry PS00606 Beta-ketoacyl synthases active site. Also contains possible hydrophobic membrane spanning regions gene gene1302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1316 SCO1317 SCO1317 SCBAC36F5.28c SCBAC36F5.28c 1392691 1393128 - hypothetical protein SCBAC36F5.28c%2C conserved hypothetical protein%2C len: 145 aa%3B similar to TR:Q9RSU3 (EMBL:AE002039) Deinococcus radiodurans hypothetical 196.9 kDa protein DR2030%2C 159 aa%3B fasta scores: opt: 222 Z-score: 270.7 bits: 56.2 E(): 1.8e-07%3B 36.296%25 identity in 135 aa overlap gene gene1303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1317 SCO1318 SCO1318 SCBAC36F5.29 SCBAC36F5.29 1393213 1394196 + hypothetical protein SCBAC36F5.29%2C membrane protein%2C len: 327 aa%3B C-terminal region similar to TR:Q9K414 (EMBL:AL359949) Streptomyces coelicolor hypothetical 18.8 kDa protein (fragment) 2SCG61.01%2C 174 aa%3B fasta scores: opt: 528 Z-score: 469.6 bits: 94.3 E(): 1.5e-18%3B 46.429%25 identity in 168 aa overlap. Contains possible hydrophobic membrane spanning region in N-terminal domain gene gene1304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1318 SCO1319 SCO1319 2SCG61.01 2SCG61.01 1394273 1395295 + hypothetical protein 2SCG61.01%2C unknown%2C partial CDS%2C len: >174 aa~SCBAC36F5.30%2C membrane protein (fragment)%2C len: >199 aa%3B similar to N-terminal region of TR:O88067 (EMBL:AL031541) Streptomyces coelicolor membrane protein SCI35.32c%2C 319 aa%3B fasta scores: opt: 227 Z-score: 214.6 bits: 47.2 E(): 0.00024%3B 33.333%25 identity in 162 aa overlap and to N-terminal region of Streptomyces coelicolor hypothetical protein SCBAC36F5.29%2C 327 aa%3B fasta scores: opt: 337 Z-score: 288.4 bits: 60.9 E(): 2.4e-10%3B 47.291%25 identity in 203 aa overlap. Contains possible hydrophobic membrane spanning region gene gene1305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1319 SCO1320 SCO1320 2SCG61.02c 2SCG61.02c 1395319 1396164 - hypothetical protein 2SCG61.02c%2C unknown%2C len: 281 aa%3B contains region of alignment with TR:CAB84350 (EMBL:AL162755) transferase from Neisseria meningitidis (263 aa) fasta scores%3B opt: 184%2C z-score: 212.1%2C E(): 0.00025%2C 27.7%25 identity in 148 aa overlap gene gene1306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1320 SCO1321 SCO1321 tuf tuf 1396238 1397416 - elongation factor Tu EF-Tu%3B promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B when the tRNA anticodon matches the mRNA codon%2C GTP hydrolysis results%3B the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts%3B many prokaryotes have two copies of the gene encoding EF-Tu gene gene1307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1321 SCO1322 SCO1322 2SCG61.04c 2SCG61.04c 1397508 1398413 - hypothetical protein 2SCG61.04c%2C unknown%2C len: 301aa%3B contains a serine-rich region. gene gene1308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1322 SCO1323 SCO1323 2SCG61.05c 2SCG61.05c 1398463 1399239 + hypothetical protein 2SCG61.05c%2C possible integral membrane protein%2C len: 258aa%3B similar to many eg. TR:Q9RKH4 (EMBL:AL133252) integral membrane protein from Streptomyces coelicolor (249 aa) fasta scores%3B opt: 353%2C z-score: 396.9%2C E(): 1.2e-14%2C 33.2%25 identity in 244 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene1309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1323 SCO1324 SCO1324 2SCG61.06c 2SCG61.06c 1399280 1400449 - 3-ketoacyl-CoA thiolase 2SCG61.06c%2C possible 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase%2C len: 389 aa%3B similar to many e.g. SW:P21151 (THIK_ECOLI) 3-ketoacyl-CoA thiolase (EC 2.3.1.16)from Escherichia coli (387 aa) fasta scores%3B opt: 892%2C z-score: 980.9%2C E(): 0%2C 42.7%25 identity in 403 aa overlap and SW:P54810 (THIL_PARDE) acetyl-CoA acetyltransferase (EC 2.3.1.9) from Paracoccus denitrificans (391 aa) fasta scores%3B opt: 892%2C z-score: 980.9%2C E(): 0%2C 41.7%25 identity in 403 aa overlap. Contains Pfam match to entry PF00108 thiolase%2C Thiolase and Prosite match to PS00737 Thiolases signature 2. gene gene1310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1324 SCO1325 SCO1325 2SCG61.07 2SCG61.07 1400584 1401057 + hypothetical protein 2SCG61.07%2C conserved hypothetical protein%2C len: 157 aa%3B similar to many e.g. SW:O05774 (YU95_MYCTU) hypothetical protein from Mycobacterium tuberculosis (158 aa) fasta scores%3B opt: 407%2C z-score: 510.5%2C E(): 5.9e-21%2C 43.9%25 identity in 139 aa overlap and TR:Q9RD98 (EMBL:AL136058) conserved hypothetical protein from Streptomyces coelicolor (184 aa) fasta scores%3B opt: 337%2C z-score: 423.9%2C E(): 3.9e-16%2C 42.1%25 identity in 140 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function gene gene1311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1325 SCO1326 SCO1326 uppP uppP 1401207 1402082 + UDP pyrophosphate phosphatase phosphatase activity in Escherichia coli not kinase%3B involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell gene gene1312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1326 SCO1327 SCO1327 2SCG61.09 2SCG61.09 1402574 1403737 + hypothetical protein 2SCG61.09%2C possible integral membrane protein%2C len: 387 aa%3B similar to many predicted integral membrane protein especially others from Streptomyces coelicolor e.g. TR:CAB69689 (EMBL:AL137165) integral membrane protein (375 aa) fasta scores%3B opt: 481%2C z-score: 562.8%2C E(): 7.2e-24%2C 35.7%25 identity in 387 aa overlap. Contains possible membrane-spanning hydrophobic regions gene gene1313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1327 SCO1328 SCO1328 2SCG61.10c 2SCG61.10c 1403709 1404566 - hypothetical protein 2SCG61.10c%2C unknown%2C len: 285aa gene gene1314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1328 SCO1329 SCO1329 2SCG61.11c 2SCG61.11c 1404801 1405034 - hypothetical protein 2SCG61.11c%2C unknown%2C len: 77aa gene gene1315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1329 SCO1330 SCO1330 2SCG61.12c 2SCG61.12c 1405031 1406113 - fatty acid CoA ligase 2SCG61.12c%2C possible fatty acid CoA ligase%2C len: 360aa%3B region similar to many possible fatty acid coA ligases eg. TR:Q9ZIP5 (EMBL:AF117694) malonyl CoA synthetase from Rhizobium trifolii (504 aa) fasta scores%3B opt: 198%2C z-score: 230.9%2C E(): 2.2e-05%2C 28.6%25 identity in 203 aa overlap. gene gene1316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1330 SCO1331 SCO1331 2SCG61.13 2SCG61.13 1406138 1408480 + multidomain-containing protein family 2SCG61.13%2C possible multi-domain regulatory protein%2C len: 780aa%3B similar to proposed regulatory proteins eg. TR:Q11028 (EMBL:Z75555) probable transcriptional regulatory protein from Mycobacterium tuberculosis (1159 aa) fasta scores%3B opt: 743%2C z-score: 848.5%2C E(): 0%2C 31.1%25 identity in 903 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop).Also contains a TTA encoded leucine amino acid at residue 649 (possible target for bldA regulation) which may allow for expression of the protein without the C-terminal domain. gene gene1317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1331 SCO1332 SCO1332 2SCG61.14c 2SCG61.14c 1408850 1409722 - hypothetical protein 2SCG61.14c%2C unknown%2C len: 290 aa%3B similar to TR:Q9Z9I2 (EMBL:AB024056) unknown protein from Streptomyces fradiae (306 aa) fasta scores%3B opt: 705%2C z-score: 786.1%2C E(): 0%2C 45.9%25 identity in 259 aa overlap and TR:CAB92673 (EMBL:AL356832) hypothetical protein from Streptomyces coelicolor (342 aa) fasta scores%3B opt: 577%2C z-score: 644.3%2C E(): 2.1e-28%2C 43.6%25 identity in 280 aa overlap gene gene1318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1332 SCO1333 SCO1333 2SCG61.15 2SCG61.15 1410027 1410995 + hypothetical protein 2SCG61.15%2C possible integral membrane protein%2C len: 322 aa%3B similar to TR:CAC44603 (EMBL:AL596162) Streptomyces coelicolor integral membrane protein SCBAC16H6.24c%2C 294 aa%3B fasta scores: opt: 900 Z-score: 871.5 E(): 6.5e-41%3B 52.597%25 identity in 308 aa overlap. Contains possible membrane-spanning hydrophobic regions gene gene1319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1333 SCO1334 SCO1334 2SCG61.16 2SCG61.16 1411647 1411826 + hypothetical protein 2SCG61.16%2C unknown%2C len: 59aa gene gene1320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1334 SCO1335 SCO1335 2SCG61.17c 2SCG61.17c 1411885 1412625 - oxidoreductase 2SCG61.17c%2C probable oxidoreductase%2C len: 246 aa%3B similar to many eg. SW:P40288 (DHG_BACME) glucose 1-dehydrogenase (EC 1.1.1.47) from Bacillus megaterium (261 aa) fasta scores%3B opt: 511%2C z-score: 535.5%2C E(): 2.4e-22%2C 36.6%25 identity in 243 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Pfam match to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. gene gene1321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1335 SCO1336 SCO1336 2SCG61.18 2SCG61.18 1412774 1414348 + lipoprotein N-acyltransferase (integral membrane) 2SCG61.18%2C possible lipoprotein N-acyltransferase (integral membrane)%2C len: 534a%3B similar to many e.g. SW:P23930 (LNT_ECOLI) apolipoprotein N-acyltransferase (EC 2.3.1.-) from Escherichia coli (512 aa) fasta scores%3B opt: 391%2C z-score: 419.0%2C E(): 7.3e-16%2C 27.0%25 identity in 515 aa overlap and TR:O53536 (EMBL:AL021925) hypothetical protein from Mycobacterium tuberculosis (360 aa) fasta scores%3B opt: 955%2C z-score: 1020.2%2C E(): 0%2C 49.2%25 identity in 317 aa overlap. C-terminal portion contains Pfam match to entry PF00795 CN_hydrolase%2C Carbon-nitrogen hydrolase. N-terminal portion contains possible membrane-spanning hydrophobic regions gene gene1322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1336 SCO1337 SCO1337 2SCG61.19c 2SCG61.19c 1414272 1415177 - oxidoreductase 2SCG61.19c%2C possible oxidoreductase%2C len: 301 aa%3B similar to SW:P37168 (MVIM_SALTY) virulence factor MviM from Salmonella typhimurium (307 aa) fasta scores%3B opt: 467%2C z-score: 533.5%2C E(): 3.1e-22%2C 33.9%25 identity in 304 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene1323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1337 SCO1338 SCO1338 2SCG61.20c 2SCG61.20c 1415191 1416381 - monooxygenase 2SCG61.20c%2C possible monooxygenase (hypothetical protein)%2C len: 396 aa%3B similar to many eg. TR:Q9Z4Y6 (EMBL:AL035707) salicylate hydroxylase from Streptomyces coelicolor (420 aa) fasta scores%3B opt: 505%2C z-score: 556.8%2C E(): 1.5e-23%2C 34.8%25 identity in 391 aa overlap and TR:Q9ZSN7 (EMBL:AF098947) CTF2B from Arabidopsis thaliana (Mouse-ear cress) (428 aa) fasta scores%3B opt: 464%2C z-score: 511.9%2C E(): 4.9e-21%2C 30.8%25 identity in 383 aa overlap. Contains Pfam match to entry PF01494 FAD_binding_3%2C FAD binding domain and Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. Contains possible N-terminal region signal peptide sequence gene gene1324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1338 SCO1339 SCO1339 2SCG61.21 2SCG61.21 1416484 1417104 + hypothetical protein 2SCG61.21%2C hypothetical protein%2C len: 206 aa%3B similar to TR:Q9X9V5 (EMBL:AL096743) hypothetical protein from Streptomyces coelicolor (197 aa) fasta scores%3B opt: 212%2C z-score: 254.4%2C E(): 1.1e-06%2C 33.9%25 identity in 186 aa overlap. gene gene1325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1339 SCO1340 SCO1340 2SCG61.22 2SCG61.22 1417147 1417659 + hypothetical protein 2SCG61.22%2C conserved hypothetical protein%2C len: 170 aa%3B similar to others of unknown function from Streptomyces coelicolor e.g. TR:CAA20815 (EMBL:AL031541) hypothetical protein (175 aa) fasta scores%3B opt: 568%2C z-score: 738.0%2C E(): 0%2C 52.1%25 identity in 169 aa overlap%2C to SW:YM2_STRCO (EMBL:X15942) mini-circle hypothetical 13.3 kD protein (122 aa) fasta scores%3B opt: 366%2C z-score: 482.1%2C E(): 2.2e-19%2C 47.2%25 identity in 123 aa overlap and to TR:Q9AJE6 (EMBL:AB048795) Kitasatospora griseola hypothetical protein%2C 170 aa%3B fasta scores: opt: 614 Z-score: 754.9 E(): 2.1e-34%3B 56.140%25 identity in 171 aa overlap gene gene1326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1340 SCO1341 SCO1341 2SCG61.23 2SCG61.23 1417763 1418269 + lipoprotein 2SCG61.23%2C possible lipoprotein%2C len: 168aa%3B contains an appropriately Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible non-cleavable N-terminal signal sequence. gene gene1327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1341 SCO1342 SCO1342 2SCG61.24c 2SCG61.24c 1418317 1418868 - hypothetical protein 2SCG61.24c%2C unknown%2C len: 183aa gene gene1328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1342 SCO1343 SCO1343 2SCG61.25c 2SCG61.25c 1418995 1419678 - uracil-DNA glycosylase Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine gene gene1329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1343 SCO1344 SCO1344 2SCG61.26c 2SCG61.26c 1419752 1421344 - solute binding transport lipoprotein 2SCG61.26c%2C possible solute binding transport lipoprotein%2C len: 530aa%3B similar to many eg. TR:Q9RJ53 (EMBL:AL132648) lipoprotein oligopeptide binding protein (534 aa) fasta scores%3B opt: 1438%2C z-score: 1620.4%2C E(): 0%2C 43.4%25 identity in 539 aa overlap and SW:P76128 (YDDS_ECOLI) binding protein YddS precursor (516 aa) fasta scores%3B opt: 532%2C z-score: 600.2%2C E(): 5.9e-26%2C 25.7%25 identity in 517 aa overlap. Contains two Pfam match to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5 and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene1330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1344 SCO1345 SCO1345 fabG fabG 1421547 1422308 - 3-ketoacyl-ACP reductase Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis gene gene1331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1345 SCO1346 SCO1346 2SCG61.28c 2SCG61.28c 1422352 1423113 - 3-oxoacyl-ACP reductase gene gene1332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1346 SCO1347 SCO1347 2SCG61.29 2SCG61.29 1423379 1424143 + hypothetical protein 2SCG61.29%2C possible membrane protein%2C len: 254 aa%3B contains possible N-terminal signal sequence and possible membrane-spanning hydrophobic region at C-terminus. gene gene1333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1347 SCO1348 SCO1348 2SCG61.30c 2SCG61.30c 1424234 1424617 - hypothetical protein 2SCG61.30c%2C unknown%2C len: 298aa gene gene1334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1348 SCO1349 SCO1349 2SCG61.31c 2SCG61.31c 1424614 1425369 - hypothetical protein 2SCG61.31c%2C hypothetical protein%2C len: 251aa%3B strongly similar to TR:Q9RCK7 (EMBL:AJ242827) hypothetical protein from Streptomyces tendae (266 aa) fasta scores%3B opt: 1417%2C z-score: 167%2C3.0 E(): 0%2C 84.3%25 identity in 249 aa overlap and TR:Q9RKV0 (EMBL:AL132824) hypothetical protein from Streptomyces coelicolor (304 aa) fasta scores%3B opt: 728%2C z-score: 862.7%2C E(): 0%2C 55.5%25 identity in 247 aa overlap gene gene1335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1349 SCO1350 SCO1350 2SCG61.32 2SCG61.32 1425591 1426211 + hypothetical protein 2SCG61.32%2C unknown%2C len: 206 aa%3B weakly similar to others from Streptomyces coelicolor eg. TR:Q9X7Q5 (EMBL:AL049587) hypothetical protein (161 aa) fasta scores%3B opt: 132%2C z-score: 160.8%2C E(): 0.18%2C 32.6%25 identity in 135 aa overlap. gene gene1336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1350 SCO1351 SCO1351 2SCG61.33 2SCG61.33 1426295 1429033 + large transcriptional regulator 2SCG61.33%2C possible large transcriptional regulator%2C len: 912 aa%3B similar to many from actinomycetes e.g. TR:Q9Z573 (EMBL:AL035569) regulatory protein from Streptomyces coelicolor (1091 aa) fasta scores%3B opt: 233%2C z-score: 243.0%2C E(): 4.6e-06%2C 26.7%25 identity in 899 aa overlap. C-terminal region contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature and a helix-turn-helix motif (residue 867-888). N-terminal region contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1351 SCO1352 SCO1352 2SCG61.34c 2SCG61.34c 1429057 1430469 - Xaa-Pro aminopeptidase II 2SCG61.34c%2C pepP%2C Xaa-Pro aminopeptidase II (EC 3.4.11.9)%2C len: 470aa%3B identical to SW:Q60394 (AMP2_STRLI) from Streptomyces lividans. Similar to many others eg. SW:P15034 (AMPP_ECOLI) Xaa-Pro aminopeptidase II (EC 3.4.11.9) from Escherichia coli (440 aa) fasta scores%3B opt: 689%2C z-score: 807.8%2C E(): 0%2C 34.7%25 identity in 438 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24%2C metallopeptidase family M24 and Prosite match to PS00491 Aminopeptidase P and proline dipeptidase signature. gene gene1338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1352 SCO1353 SCO1353 2SCG61.35 2SCG61.35 1430545 1431576 + transcriptional regulator 2SCG61.35%2C possible transcriptional regulator%2C len: 343 aa%3B similar to many from proposed regulators from streptomyces e.g. TR:Q9ZBT5 (EMBL:AL034446) regulatory protein from Streptomyces coelicolor (327 aa) fasta scores%3B opt: 445%2C z-score: 498.6%2C E(): 2.7e-20%2C 31.7%25 identity in 325 aa overlap. Contains helix-turn-helix motif (residue 298-319) gene gene1339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1353 SCO1354 SCO1354 2SCG61.36c 2SCG61.36c 1431662 1432225 - hypothetical protein 2SCG61.36c%2C possible hypothetical protein%2C len: 187aa%3B contains a possible N-terminal signal sequence and Prosite match to PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. gene gene1340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1354 SCO1355 SCO1355 2SCG61.37c 2SCG61.37c 1432286 1433899 - serine protease 2SCG61.37c%2C possible serine protease%2C len: 537 aa%3B similar to many eg. SW:P08594 (AQL1_THEAQ) aqualysin I precursor (EC 3.4.21.-) from Thermus aquaticus (513 aa) fasta scores%3B opt: 1151%2C z-score: 1199.3%2C E(): 0%2C 45.6%25 identity in 428 aa overlap. Contains Pfam match to entry PF00082 Peptidase_S8%2C Subtilase family and Prosite matches to PS00136%2C PS00137 and PS00138 Serine proteases%2C subtilase family%2C serine active sites. Also contains possible cleavable N-terminal signal sequence. gene gene1341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1355 SCO1356 SCO1356 2SCG61.38 2SCG61.38 1434218 1434715 + iron sulfur protein 2SCG61.38%2C possible iron sulphur protein ( hypothetical protein)%2C len: 165 aa%3B similar to TR:Q9S237 (EMBL:AL109848) iron sulphur protein from Streptomyces coelicolor (131 aa) fasta scores%3B opt: 444%2C z-score: 411.3%2C E(): 1.9e-15%2C 53.4%25 identity in 116 aa overlap. Contains Pfam match to entry PF00355 Rieske%2C Rieske [2Fe-2S] domain and Prosite match to PS00200 Rieske iron-sulfur protein signature 2. Contains possible N-terminal region signal peptide sequence gene gene1342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1356 SCO1357 SCO1357 2SCG61.39 2SCG61.39 1434718 1435179 + hypothetical protein 2SCG61.39%2C hypothetical protein%2C len: 153 aa%3B similar to TR:O53240 (EMBL:AL021287) hypothetical protein from Mycobacterium tuberculosis (163 aa) fasta scores%3B opt: 266%2C z-score: 354.4%2C E(): 2.9e-12%2C 34.8%25 identity in 155 aa overlap. gene gene1343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1357 SCO1358 SCO1358 2SCG61.40c 2SCG61.40c 1435312 1436223 - LysR family transcriptional regulator 2SCG61.40c%2C possible LysR-family transcriptional regulator%2C len: 303 aa%3B similar to many e.g. SW:P11721 (OXYR_ECOLI) hydrogen peroxide-inducible genes activator from Escherichia coli (305 aa) fasta scores%3B opt: 359%2C z-score: 409.3%2C E(): 2.5e-15%2C 27.6%25 identity in 297 aa overlap and TR:Q9RDH0 (EMBL:AL136519) LysR-family transcriptional regulator from Streptomyces coelicolor (313 aa) fasta scores%3B opt: 897%2C z-score: 1010.0%2C E(): 0%2C 49.0%25 identity in 294 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and Prosite match to PS00044 Bacterial regulatory proteins%2C lysR family signature. gene gene1344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1358 SCO1359 SCO1359 2SCG61.41 2SCG61.41 1436298 1437296 + hypothetical protein SC10A9.01%2C possible integral membrane protein (fragment)%2C len: >191 aa%3B similar to TR:Q9S248 (EMBL:AL096811) Streptomyces coelicolor possible integral membrane conserved hypothetical protein SCI30A.25%2C 324 aa%3B fasta scores: opt: 206 z-score: 220.5 E(): 7.8e-05%3B 31.3%25 identity in 176 aa overlap. Contains Pfam match to entry PF00892 DUF6%2C Integral membrane protein DUF6 and possible hydrophobic membrane spanning regions~2SCG61.41%2C possible integral membrane protein%2C partial CDS%2C len: >181aa%3B weakly similar to other membrane proteins eg. TR:CAB88171 (EMBL:AL352972) integral membrane protein from Streptomyces coelicolor (326 aa) fasta scores%3B opt: 195%2C z-score: 241.4%2C E(): 5.7e-06%2C 29.1%25 identity in 158 aa overlap. Contains Pfam match to entry PF00892 DUF6%2C Integral membrane protein. gene gene1345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1359 SCO1360 SCO1360 SC10A9.02c SC10A9.02c 1437760 1439097 - GntR family transcriptional regulator SC10A9.02c%2C probable gntR-family transcriptional regulator%2C len: 445 aa%3B similar to SW:PTSJ_SALTY (EMBL:U11243) Salmonella typhimurium transcriptional regulatory protein PtsJ%2C 430 aa%3B fasta scores: opt: 968 z-score: 1010.8 E(): 0%3B 40.4%25 identity in 433 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and possible helix-turn-helix motif at residues 35..56 (+4.36 SD) gene gene1346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1360 SCO1361 SCO1361 SC10A9.03 SC10A9.03 1439133 1439819 + hypothetical protein SC10A9.03%2C conserved hypothetical protein%2C len: 228 aa%3B similar to TR:Q9RW27 (EMBL:AE001938) Deinococcus radiodurans NimA-related protein DR0842%2C 195 aa%3B fasta scores: opt: 210 z-score: 256.7 E(): 7.4e-07%3B 30.5%25 identity in 197 aa overlap and to TR:Q98JR3 (EMBL:AP002998) Rhizobium loti (Mesorhizobium loti) MLL1820 protein%2C 251 aa%3B fasta scores: opt: 589 Z-score: 692.3 E(): 6.3e-31%3B 42.478%25 identity in 226 aa overlap gene gene1347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1361 SCO1362 SCO1362 SC10A9.04c SC10A9.04c 1439866 1440840 - hypothetical protein SC10A9.04c%2C possible integral membrane protein%2C len: 324 aa%3B similar to SW:YWFM_BACSU (EMBL:X73124) Bacillus subtilis hypothetical 31.3 kDa protein in Pta 3' region Ywfm%2C 296 aa%3B fasta scores: opt: 267 z-score: 282.4 E(): 2.7e-08%3B 26.9%25 identity in 305 aa overlap. Contains 2x Pfam matches to entry PF00892 DUF6%2C Integral membrane protein DUF6. Also contains possible hydrophobic membrane spanning regions and a 4x degenerate repeat: LRP(R/A) gene gene1348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1362 SCO1363 SCO1363 SC10A9.05c SC10A9.05c 1441026 1442030 - hypothetical protein SC10A9.05c%2C possible integral membrane protein%2C len: 334 aa%3B low similarity to SW:YCBK_BACSU (EMBL:D30808) Bacillus subtilis hypothetical 34.0 kDa protein in GltP-Pcp intergenic region YcbK%2C 312 aa%3B fasta scores: opt: 200 z-score: 236.4 E(): 1e-05%3B 22.6%25 identity in 292 aa overlap. Contains 2x Pfam matches to entry PF00892 DUF6%2C Integral membrane protein DUF6. Also contains possible hydrophobic membrane spanning regions gene gene1349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1363 SCO1364 SCO1364 SC10A9.06c SC10A9.06c 1442209 1442748 - hypothetical protein SC10A9.06c%2C unknown%2C len: 179 aa gene gene1350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1364 SCO1365 SCO1365 SC10A9.07 SC10A9.07 1442967 1443134 + hypothetical protein SC10A9.07%2C unknown%2C len: 55 aa gene gene1351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1365 SCO1366 SCO1366 SC10A9.08c SC10A9.08c 1443255 1443908 - hypothetical protein SC10A9.08c%2C hypothetical protein%2C len: 219 aa%3B similar to TR:CAC05955 (EMBL:AL391763) Streptomyces coelicolor hypothetical 40.1 kDa protein 2SC7G11.14c%2C 360 aa%3B fasta scores: opt: 237 z-score: 225.1 E(): 4.3e-05%3B 34.5%25 identity in 145 aa overlap and to TR:Q9CB82 (EMBL:AL583925) Mycobacterium leprae hypothetical protein ML2313%2C 200 aa%3B fasta scores: opt: 526 Z-score: 466.8 E(): 2.3e-18%3B 49.171%25 identity in 181 aa overlap. Contains C-terminal region rich in glycine%2C arginine and proline amino acid residues gene gene1352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1366 SCO1367 SCO1367 SC10A9.09c SC10A9.09c 1443901 1444656 - ABC transporter ATP-binding protein SC10A9.09c%2C probable ABC transport system ATP-binding protein%2C len: 251 aa%3B similar to SW:LOLD_ECOLI (EMBL:AE000212) Escherichia coli lipoprotein releasing system ATP-binding protein LolD%2C 233 aa%3B fasta scores: opt: 530 z-score: 576.0 E(): 1.2e-24%3B 40.8%25 identity in 218 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene1353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1367 SCO1368 SCO1368 SC10A9.10c SC10A9.10c 1444653 1445792 - ABC transporter SC10A9.10c%2C possible ABC transport system transmembrane protein%2C len: 379 aa%3B low similarity to TR:O53617 (EMBL:AL021428) Mycobacterium tuberculosis ABC-transporter transmembrane subunit%2C 349 aa%3B fasta scores: opt: 175 z-score: 176.6 E(): 0.022%3B 24.3%25 identity in 387 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1368 SCO1369 SCO1369 SC10A9.11 SC10A9.11 1445966 1447180 + two component system histidine kinase SC10A9.11%2C probable two component system histidine kinase%2C len: 404 aa%3B highly similar to TR:Q9RIM1 (EMBL:Y14336) Streptomyces reticuli histidine autokinase SenS%2C 398 aa%3B fasta scores: opt: 911 z-score: 966.5 E(): 0%3B 46.0%25 identity in 404 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase and N-terminal region possible hydrophobic membrane spanning regions gene gene1355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1369 SCO1370 SCO1370 SC10A9.12 SC10A9.12 1447177 1447812 + two component system DNA binding response regulator SC10A9.12%2C probable two component system DNA binding response regulator%2C len: 211 aa%3B similar to SW:NARP_ECOLI (EMBL:L11273) Escherichia coli nitrate/nitrite response regulator protein NarP%2C 215 aa%3B fasta scores: opt: 467 z-score: 529.1 E(): 5e-22%3B 41.1%25 identity in 202 aa overlap and to TR:Q9RIM0 (EMBL:Y14336) Streptomyces reticuli response regulatory protein SenR%2C 217 aa%3B fasta scores: opt: 699 z-score: 785.2 E(): 0%3B 56.5%25 identity in 200 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains possible helix-turn-helix motif at residues 164..185 (+4.15 SD) gene gene1356 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1370 SCO1371 SCO1371 SC10A9.13 SC10A9.13 1447950 1448759 + oxidoreductase SC10A9.13%2C probable oxidoreductase%2C len: 278 aa%3B similar to SW:PHZF_PSEFL (EMBL:L48616) Pseudomonas fluorescens phenazine biosynthesis protein PhzF%2C 278 aa%3B fasta scores: opt: 279 z-score: 322.8 E(): 1.5e-10%3B 30.9%25 identity in 285 aa overlap gene gene1357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1371 SCO1372 SCO1372 SC10A9.14c SC10A9.14c 1448786 1449613 - hypothetical protein SC10A9.14c%2C possible integral membrane protein%2C len: 275 aa. Contains possible hydrophobic membrane spanning regions gene gene1358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1372 SCO1373 SCO1373 SC10A9.15c SC10A9.15c 1449695 1451212 - hypothetical protein SC10A9.15c%2C conserved hypothetical protein%2C len: 505 aa%3B similar to TR:O69666 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 56.9 kDa protein MTV025.046%2C 509 aa%3B fasta scores: opt: 1720 z-score: 2047.1 E(): 0%3B 53.6%25 identity in 494 aa overlap gene gene1359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1373 SCO1374 SCO1374 SC10A9.16 SC10A9.16 1451745 1452356 + hypothetical protein SC10A9.16%2C hypothetical protein%2C len: 203 aa. Contains possible N-terminal region signal peptide sequence gene gene1360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1374 SCO1375 SCO1375 SC10A9.17 SC10A9.17 1452656 1452859 + hypothetical protein SC10A9.17%2C unknown%2C len: 67 aa: similar to TR:Q9AD54 (EMBL:AL590463) SCP1.96 from Streptomyces coelicolor plasmid SCP1. gene gene1361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1375 SCO1376 SCO1376 SC10A9.18 SC10A9.18 1453090 1454160 + LacI family transcriptional regulator SC10A9.18%2C probable lacI-family transcriptional regulatory protein%2C len: 356 aa%3B similar to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR%2C 340 aa%3B fasta scores: opt: 681 z-score: 700.7 E(): 1.4e-31%3B 40.7%25 identity in 339 aa overlap and to TR:O86795 (EMBL:AL031317) Streptomyces coelicolor probable transcriptional regulator SC6G4.32%2C 355 aa%3B fasta scores: opt: 1196 z-score: 1059.6 E(): 0%3B 56.7%25 identity in 344 aa overlap. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Also contains a possible helix-turn-helix motif at residues 12..39 (+7.22 SD) gene gene1362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1376 SCO1377 SCO1377 SC10A9.19 SC10A9.19 1454293 1454712 + molibdenum binding protein SC10A9.19%2C possible molibdenum binding protein%2C len: 139 aa%3B similar to C-terminal region of SW:MOPA_RHOCA (EMBL:L06254) Rhodobacter capsulatus molybdenum-pterin binding protein MopA%2C 265 aa%3B fasta scores: opt: 280 z-score: 319.9 E(): 2.2e-10%3B 41.7%25 identity in 139 aa overlap gene gene1363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1377 SCO1378 SCO1378 SC10A9.20c SC10A9.20c 1454780 1457665 - glycine dehydrogenase acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine gene gene1364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1378 SCO1379 SCO1379 SC10A9.21 SC10A9.21 1458078 1458473 + hypothetical protein SC10A9.21%2C hypothetical protein%2C len: 131 aa%3B similar to TR:Q9RJP4 (EMBL:AL132991) Streptomyces coelicolor hypothetical 14.5 kDa protein SCF55.21c%2C 131 aa%3B fasta scores: opt: 195 z-score: 246.8 E(): 2.7e-06%3B 33.3%25 identity in 96 aa overlap gene gene1365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1379 SCO1380 SCO1380 SC10A9.22c SC10A9.22c 1458383 1459822 - DNA polymerase IV involved in translesion DNA polymerization with beta clamp of polymerase III%3B belongs to Y family of polymerases%3B does not contain proofreading function gene gene1366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1380 SCO1381 SCO1381 SC10A9.23c SC10A9.23c 1459887 1460573 - hypothetical protein SC1A8A.01c%2C partial CDS%2C hypothetical protein%2C len: >183aa%3B similar to SW:Q50603 (Y0DD_MYCTU) hypothetical protein from Mycobacterium tuberculosis (225 aa) fasta scores%3B opt: 641%2C z-score: 633.8%2C E(): 7.1e-28%2C 64.7%25 identity in 150 aa overlap. Note possible alternative translational start sites downstream.~SC10A9.23c%2C conserved hypothetical protein (fragment)%2C len: >78 aa%3B similar to SW:YI30_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical 24.0 kDa protein MTCY1A11.13c%2C 225 aa%3B fasta scores: opt: 269 z-score: 377.2 E(): 1.4e-13%3B 56.0%25 identity in 75 aa overlap gene gene1367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1381 SCO1382 SCO1382 SC1A8A.02c SC1A8A.02c 1460736 1461209 - hypothetical protein SC1A8A.02c%2C conserved hypothetical protein%2C len: 157aa%3B similar to many eg. SW:Q50604 (Y0DE_MYCTU) hypothetical protein from Mycobacterium tuberculosis (164 aa) fasta scores%3B opt: 592%2C z-score: 709.0%2C E(): 4.6e-32%2C 60.2%25 identity in 161 aa overlap gene gene1368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1382 SCO1383 SCO1383 SC1A8A.03c SC1A8A.03c 1461293 1462033 - hypothetical protein SC1A8A.03c%2C hypothetical protein%2C len: 246aa%3B similar to SW:Q50605 (Y0DF_MYCTU) hypothetical protein from Mycobacterium tuberculosis (247 aa) fasta scores%3B opt: 359%2C z-score: 418.8%2C E(): 6.8e-16%2C 42.2%25 identity in 230 aa overlap. gene gene1369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1383 SCO1384 SCO1384 SC1A8A.04c SC1A8A.04c 1462078 1462881 - hypothetical protein SC1A8A.04c%2C hypothetical protein%2C len: 267aa%3B similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores%3B opt: 503%2C z-score: 488.2%2C E(): 9.2e-20%2C 56.0%25 identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA%2C FHA domain gene gene1370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1384 SCO1385 SCO1385 SC1A8A.05c SC1A8A.05c 1463072 1463926 - hypothetical protein SC1A8A.05c%2C membrane protein%2C len: 284 aa%3B similar to SW:Q50608 (Y0DI_MYCTU) hypothetical protein from Mycobacterium tuberculosis (292 aa) fasta scores%3B opt: 421%2C z-score: 440.5%2C E(): 4.2e-17%2C 33.6%25 identity in 277 aa overlap. Contains potential coiled-coil region 106-140 aa. Contains possible hydrophobic membrane spanning region gene gene1371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1385 SCO1386 SCO1386 SC1A8A.06c SC1A8A.06c 1463932 1464264 - hypothetical protein SC1A8A.06c%2C possible integral membrane protein%2C len: 110 aa%3B similar to SW:Q50609 (Y0DJ_MYCTU) hypothetical protein from Mycobacterium tuberculosis (121 aa) fasta scores%3B opt: 478%2C z-score: 600.3%2C E(): 5.2e-26%2C 67.3%25 identity in 110 aa overlap. Contains possible hydrophobic membrane spannig regions gene gene1372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1386 SCO1387 SCO1387 SC1A8A.07c SC1A8A.07c 1464261 1465166 - membrane associated protein SC1A8A.07c%2C possible membrane associated protein%2C len: 110 aa%3B similar to SW:Q50610 (Y0DK_MYCTU) hypothetical protein from Mycobacterium tuberculosis (307 aa) fasta scores%3B opt: 499%2C z-score: 537.1%2C E(): 1.7e-22%2C 38.3%25 identity in 282 aa overlap. Contains possible membrane-spanning hydrophobic region 60-75 aa and potential coiled-coil region 100-122 aa gene gene1373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1387 SCO1388 SCO1388 SC1A8A.08c SC1A8A.08c 1465266 1467761 - mannose-1-phosphate guanyltransferase SC1A8A.08c%2C possible mannose-1-phosphate guanyltransferase%2C len: 831aa%3B similar to many eg. TR:P74589 (EMBL:D90916) mannose-1-phosphate guanyltransferase from Synechocystis sp. (strain PCC 6803) (843 aa) fasta scores%3B opt: 2184%2C z-score: 2364.6%2C E(): 0%2C 39.7%25 identity in 817 aa overlap and SW:P41940 (MPG1_YEAST) mannose-1-phosphate guanyltransferase from Saccharomyces cerevisiae (Baker's yeast) (361 aa). Contains Pfam match to entry PF00483 NTP_transferase%2C Nucleotidyl transferase%2C four Pfam match to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) and Pfam match to entry PF00408 PGM_PMM%2C Phosphoglucomutase/phosphomannomutase. gene gene1374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1388 SCO1389 SCO1389 SC1A8A.09c SC1A8A.09c 1467874 1468521 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SC1A8A.09c%2C possible CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase%2C len: 206 aa%3B similar to many eg. SW:Q50611 (PGSA_MYCTU) CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Mycobacterium tuberculosis (209 aa) fasta scores%3B opt: 504%2C z-score: 637.7%2C E(): 4.3e-28%2C 43.5%25 identity in 193 aa overlap and SW:P06978 (PGSA_ECOLI ) CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Escherichia coli (181 aa) fasta scores%3B opt: 232%2C z-score: 299.4 E(): 3e-09%2C 29.3%25 identity in 174 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf%2C CDP-alcohol phosphatidyltransferase and Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature. Contains possible hydrophobic membrane spanning region gene gene1375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1389 SCO1390 SCO1390 SC1A8A.10 SC1A8A.10 1474291 1474740 + PTS system sugar phosphotransferase component IIA SC1A8A.10%2C possible PTS system sugar phosphotransferase component IIA%2C len: 176a%3B similar to many e.g. TR:BAA82669 (EMBL:AB030569) phosphoenolpyruvate:carbohydrate phosphotransferase system family from Streptomyces griseus (149 aa) fasta scores%3B opt: 897%2C z-score: 951.7%2C E(): 0%2C 88.6%25 identity in 149 aa overlap and SW:P42015 (PTGA_BACST) PTS system%2C glucose-specific IIABC component from Bacillus stearothermophilus (324 aa) fasta scores%3B opt: 359%2C z-score: 386.4%2C E(): 4.3e-14%2C 40.6%25 identity in 143 aa overlap. Contains Pfam match to entry PF00358 PTS_EIIA_1%2C phosphoenolpyruvate-dependent sugar phosphotransferase system%2C EIIA 1 and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1390 SCO1391 SCO1391 SC1A8A.11 SC1A8A.11 1474827 1476497 + phosphoenolpyruvate-protein phosphotransferase SC1A8A.11%2C phosphoenolpyruvate-protein phosphotransferase%2C len: 556 aa%3B similar to many e.g. SW:P08839 (PT1_ECOLI) PtsI%2C phosphoenolpyruvate-protein phosphotransferase from Escherichia coli (575 aa) fasta scores%3B opt: 473%2C z-score: 494.3%2C E(): 4.2e-20%2C 34.6%25 identity in 570 aa overlap. Contains Pfam match to entry PF00391 PEP-utilizers%2C PEP-utilizing enzymes%2C Prosite match to PS00370 PEP-utilizing enzymes phosphorylation site signature%2C Prosite match to PS00742 PEP-utilizing enzymes signature 2 and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1391 SCO1392 SCO1392 SC1A8A.12c SC1A8A.12c 1476570 1477472 - hypothetical protein SC1A8A.12%2C unknown%2C len: 300aa gene gene1381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1392 SCO1393 SCO1393 acsA acsA 1477596 1479572 - acetoacetate-CoA ligase AcsA%3B in Sinorhizobium meliloti this enzyme is required for acetoacetate activation%3B similar to acetyl-CoA synthase gene gene1382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1393 SCO1394 SCO1394 SC1A8A.14 SC1A8A.14 1479786 1482173 + glycosyl hydrolase SC1A8A.14%2C possible glycosyl hydrolase%2C len: 795 aa%3B similar to many e.g. SW:O59645 (AGLU_SULSO) alpha-glucosidase from Sulfolobus solfataricus (693 aa) fasta scores%3B opt: 535%2C z-score: 568.6%2C E(): 3e-24%2C 32.4%25 identity in 463 aa overlap. Contains Pfam match to entry PF01055 Glyco_hydro_31%2C Glycosyl hydrolases family 31. gene gene1383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1394 SCO1395 SCO1395 SC1A8A.15c SC1A8A.15c 1482164 1482580 - mutT-like protein SC1A8A.15c%2C mutT-like protein%2C len: 138 aa%3B similar to many eg. SW:P08337 (MUTT_ECOLI) mutator mutT protein from Escherichia coli (129 aa) fasta scores%3B opt: 131%2C z-score: 177.0%2C E(): 0.02%2C 33.7%25 identity in 101 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and Prosite match to PS00893 mutT domain signature. gene gene1384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1395 SCO1396 SCO1396 SC1A8A.16c SC1A8A.16c 1482748 1483572 - D-alanyl-D-alanine dipeptidase SC1A8A.16c%2C probable D-alanyl-D-alanine dipeptidase (hypothetical protein)%2C len: 274aa%3B similar to many eg. TR:Q9X523 (EMBL:AF120672) pcgL%2C D-alanyl-D-alanine dipeptidase from Salmonella typhimurium (256 aa) fasta scores%3B opt: 851%2C z-score: 983.2%2C E(): 0%2C 49.6%25 identity in 252 aa overlap. Contains two Pfam matches to entry PF01427 Peptidase_M45%2C D-ala-D-ala dipeptidase and possible N-terminal region signal peptide sequence gene gene1385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1396 SCO1397 SCO1397 SC1A8A.17 SC1A8A.17 1483776 1484795 + hypothetical protein SC1A8A.17%2C unknown%2C len: 339aa gene gene1386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1397 SCO1398 SCO1398 SC1A8A.18 SC1A8A.18 1484800 1485507 + hypothetical protein SC1A8A.18%2C unknown%2C len: 236 aa%3B contains a region similar to many eg. SW:Q11024 (YD54_MYCTU) hypothetical protein from Mycobacterium tuberculosis (623 aa) fasta scores%3B opt: 202%2C z-score: 200.1%2C E(): 0.001%2C 31.5%25 identity in 178 aa overlap. Contains Pfam match to entry PF00990 DUF9%2C Domain of unknown function. gene gene1387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1398 SCO1399 SCO1399 cvnD4 cvnD4 1485684 1486289 - ATP/GTP-binding protein SC1A8A.19c%2C cvnD4%2C possible ATP/GTP-binding protein%2C len: 201aa%3B similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis eg. TR:Q9XAE1 (EMBL:AL079356) ATP/GTP-binding protein from Streptomyces coelicolor (191 aa) fasta scores%3B opt: 742%2C z-score: 890.7%2C E(): 0%2C 60.9%25 identity in 184 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelicolor paralogues. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1399 SCO1400 SCO1400 cvnC4 cvnC4 1486339 1486734 - hypothetical protein SC1A8A.20c%2C cvnC4%2C unknown%2C len: 131 aa%3B similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis eg. TR:O86523 (EMBL:AL031124) hypothetical protein from Streptomyces coelicolor (132 aa) fasta scores%3B opt: 262%2C z-score: 339.3%2C E(): 1.8e-11%2C 41.9%25 identity in 124 aa overlap and to TR:Q9KZI7 (EMBL:AL353863) Streptomyces coelicolor hypothetical protein SCG8A.12c%2C 137 aa%3B fasta scores: opt: 480 Z-score: 582.4 E(): 8.3e-25%3B 59.690%25 identity in 129 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelicolor paralogues gene gene1389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1400 SCO1401 SCO1401 cvnB4 cvnB4 1486745 1487179 - hypothetical protein SC1A8A.21c%2C cvnB4%2C unknown%2C len: 144 aa%3B similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis e.g. TR:Q9X835 (EMBL:AL049727) hypothetical protein from Streptomyces coelicolor (139 aa) fasta scores%3B opt: 408%2C z-score: 500.5%2C E(): 1.9e-20%2C 47.6%25 identity in 143 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelicolor paralogues gene gene1390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1401 SCO1402 SCO1402 cvnA4 cvnA4 1487176 1490007 - large hypothetical protein SC1A8A.22c%2C cvnA4%2C possible large hypothetical protein%2C len: 943aa%3B similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis eg. TR:Q9X836 (EMBL:AL049727) large hypothetical protein from Streptomyces coelicolor (877 aa) fasta scores%3B opt: 1356%2C z-score: 1302.5%2C E(): 0%2C 34.5%25 identity in 887 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelicolor paralogues. Contains a possible non-cleavable N-terminal signal sequence. gene gene1391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1402 SCO1403 SCO1403 SC1A8A.23 SC1A8A.23 1490427 1490969 + hypothetical protein SC1A8A.23%2C possible membrane protein%2C len: 180aa%3B contains possible membrane-spanning hydrophobic regions. gene gene1392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1403 SCO1404 SCO1404 SC1A8A.24c SC1A8A.24c 1491016 1494021 - hypothetical protein SC1A8A.24c%2C unknown%2C len: 1001aa%3B weakly similar to many other large proteins of undefined function eg. TR:Q9Z5A4 (EMBL:AL035478) hypothetical protein from Streptomyces coelicolor (1156 aa) fasta scores%3B opt: 210%2C z-score: 222.7%2C E(): 5.7e-05%2C 24.7%25 identity in 636 aa overlap. gene gene1393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1404 SCO1405 SCO1405 SC1A8A.25c SC1A8A.25c 1494024 1495871 - HSP90 family protein SC1A8A.25c%2C possible heat shock protein (hsp90-family)%2C len: 615aa%3B similar to many eg. TR:O43642 (EMBL:AF043254) heat shock protein 75 from Homo sapiens (Human) (649 aa) fasta scores%3B opt: 364%2C z-score: 416.0%2C E(): 9.7e-16%2C 25.5%25 identity in 639 aa overlap. Contains two Pfam matches to entry PF00183 HSP90%2C Hsp90 protein. gene gene1394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1405 SCO1406 SCO1406 SC1A8A.26c SC1A8A.26c 1495964 1496950 - hypothetical protein SC1A8A.26c%2C hypothetical protein%2C len: 328 aa%3B weakly similar to TR:CAB46782 (EMBL:AL096811) hypothetical protein from Streptomyces coelicolor (338 aa) fasta scores%3B opt: 140%2C z-score: 170.3%2C E(): 0.047%2C 26.9%25 identity in 338 aa overlap. gene gene1395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1406 SCO1407 SCO1407 SC1A8A.27c SC1A8A.27c 1497056 1501717 - hypothetical protein SC6D7.32%2C unknown%2C len: > 1425 aa. Weakly similar to several including: Streptomyces coelicolor TR:Q9Z5A4(EMBL:AL035478) hypothetical protein SC2G5.19 (1156 aa)%2C fasta scores opt: 327 z-score: 314.0 E(): 4.1e-10 28.0%25 identity in 938 aa overlap and Rhodobacter capsulatus TR:O68032(EMBL:AF010496) potential exonuclease (1238 aa)%2C fasta scores opt: 439 z-score: 421.6 E(): 4.1e-16 28.8%25 identity in 1154 aa overlap. The predicted protein product of this CDS is alanine rich and contains multiple probable coiled-coils between residues: 369 to 401 (33 residues)%2C 406 to 433 (28 residues)%2C 483 to 519 (37 residues)%2C 563 to 604 (42 residues)%2C850 to 921 (72 residues)%2C926 to 982 (57 residues)%2C 1025 to 1054 (30 residues)%2C1072 to 1106 (35 residues)%2C 1124 to 1167 (44 residues)%2C 1199 to 1232 (34 residues) and 1278 to 1309 (32 residues).~SC1A8A.26c%2C partial CDS%2C unknown%2C len: >162aa%3B forms the C-terminal region of SC6D7.32 (TR:CAB61684 EMBL:AL133213) which has weak similarity to proteins of unknown function. gene gene1396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1407 SCO1408 SCO1408 SC6D7.31 SC6D7.31 1501823 1502704 - hypothetical protein SC6D7.31%2C possible membrane protein%2C len: 293 aa. Contains a possible membrane spanning hydrophobic domain. gene gene1397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1408 SCO1409 SCO1409 SC6D7.30 SC6D7.30 1502793 1504319 - hypothetical protein SC6D7.30%2C possible membrane protein%2C len: 508 aa. Contains a possible membrane spanning hydrophobic domain and a probable coiled-coil between residues 259..286 (28 residues) gene gene1398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1409 SCO1410 SCO1410 SC6D7.29 SC6D7.29 1504428 1505123 - GntR family transcriptional regulator SC6D7.29%2C GntR-family transcriptional regulator%2C len: 231 aa. Similar to many other regulators e.g. Bacillus licheniformis SW:GNTR_BACLI(EMBL:D31631) gluconate operon transcriptional repressor (P28 protein) (243 aa)%2C fasta scores opt: 183 z-score: 234.8 E(): 1.1e-05 31.2%25 identity in 138 aa overlap and Chelatobacter heintzii SW:NTRA_CHEHE(EMBL:U39411) NTA operon transcriptional regulator (210 aa)%2C fasta scores opt: 222 z-score: 284.0 E(): 1.9e-08 31.8%25 identity in 195 aa overlap. Contains a PS00043 Bacterial regulatory proteins%2C gntR family signature and a Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. Contains a helix-turn-helix motif between residues 44..65 (+2.58 SD). gene gene1399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1410 SCO1411 SCO1411 SC6D7.28c SC6D7.28c 1505261 1506583 + transmembrane transport protein SC6D7.28c%2C possible transmembrane transport protein%2C len: 440 aa. Highly similar to many other membrane transport proteins e.g. Escherichia coli SW:CIT1_ECOLI(EMBL:M11559) citrate-proton symporter (citrate transporter) (431 aa)%2C fasta scores opt: 349 z-score: 368.9 E(): 3.6e-13 25.1%25 identity in 438 aa overlap and Yersinia pestis TR:Q9ZC42(EMBL:AL031866) transport protein (409 aa)%2C fasta scores opt: 1363 z-score: 1421.9 E():0 49.5%25 identity in 410 aa overlap. Contains a Prosite hit to PS00217 Sugar transport proteins signature 2 and a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. Also contains multiple possible membrane spanning hydrophobic domains. gene gene1400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1411 SCO1412 SCO1412 SC6D7.27c SC6D7.27c 1506580 1507413 + hypothetical protein SC6D7.27c%2C unknown%2C len: 277 aa. Highly similar to proteins of unknown function from Bacillus subtilis SW:YCSI_BACSU(EMBL:D38161) hypothetical 28.1 KD protein (257 aa)%2C fasta scores opt: 945 z-score: 1112.7 E():0 52.5%25 identity in 255 aa overlap and Schizosaccharomyces pombe (Fission yeast) SW:YA01_SCHPO(EMBL:Z49811) hypothetical 33.8 KD protein (301 aa)%2C fasta scores opt: 596 z-score: 703.6 E(): 8.1e-32 40.1%25 identity in 252 aa overlap. gene gene1401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1412 SCO1413 SCO1413 SC6D7.26 SC6D7.26 1507860 1509278 - hypothetical protein SC6D7.26%2C unknown%2C len: 472 aa. gene gene1402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1413 SCO1414 SCO1414 SC6D7.25 SC6D7.25 1509614 1510018 - ankyrin SC6D7.25. possible ankyrin%2C len: 134 aa. Similar to many Prokaryotic and Eukaryotic proteins containing ankyrin repeat domains e.g. Pseudomonas aeruginosa TR:Q51402(EMBL:U59457) AnkB (ankyrin) (180 aa)%2C fasta scores opt: 263 z-score: 329.0 E(): 6e-11 40.7%25 identity in 118 aa overlap and Xiphophorus helleri TR:AAD21313(EMBL:AF132500) P13CDKN2X (124 aa)%2C fasta scores opt: 192 z-score: 246.7 E(): 2.3e-06 34.7%25 identity in 121 aa overlap. Also similar to Streptomyces coelicolor (EMBL:AL121855) hypothetical protein SCF62.06 (131 aa)%2C fasta scores opt:387 z-score: 407.2 E(): 2.5e-17 53.8%25 identity in 119 aa overlap. Contains 2xPfam match to entry PF00023 ank%2C Ank repeat. gene gene1403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1414 SCO1415 SCO1415 SC6D7.24c SC6D7.24c 1510276 1510470 + hypothetical protein SC6D7.24c%2C possible membrane protein%2C len: 582 aa. Highly similar to the Streptomyces coelicolor hypothetical protein SCF37.26c (64 aa)%2C fasta scores opt: 207 z-score: 284.7 E(): 1.7e-10 52.4%25 identity in 63 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1415 SCO1416 SCO1416 SC6D7.23c SC6D7.23c 1510524 1512272 + hypothetical protein SC6D7.23c%2C possible membrane protein%2C len: 582 aa. Contains a possible membrane spanning hydrophobic domain close to th N-terminus. gene gene1405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1416 SCO1417 SCO1417 SC6D7.22 SC6D7.22 1512639 1514141 - GntR family transcriptional regulator SC6D7.22%2C possible GntR-family regulatory protein%2C len: 500 aa. Similar to several including: Streptomyces coelicolor TR:O88047 (EMBL:AL031541) transcriptional regulator SCI35.09C (480 aa)%2C fasta scores opt: 403 z-score: 439.9 E(): 4e-17 29.0%25 identity in 483 aa overlap and Streptomyces venezuelae TR:AAF01064 (EMBL:AF189258) transcriptional regulator (fragment) (507 aa)%2C fasta scores opt: 444 z-score: 484.0 E(): 1.4e-19 31.8%25 identity in 462 aa overlap. Contains a Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and a Prosite hit to PS00043 Bacterial regulatory proteins%2C gntR family signature. gene gene1406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1417 SCO1418 SCO1418 SC6D7.21c SC6D7.21c 1514244 1514936 + hypothetical protein SC6D7.21c%2C possible integral membrane protein%2C len: 230 aa. Similar to several proteins of undefined function e.g. Haemophilus influenzae SW:Y522_HAEIN (EMBL:U32734) hypothetical protein HI0522 (218 aa)%2C fasta scores opt: 492 z-score: 566.3 E(): 3.6e-24 39.1%25 identity in 207 aa overlap and Bacillus subtilis SW:YYAS_BACSU(EMBL:D26185) hypothetical 22.0 KD protein (201 aa)%2C fasta scores opt: 232 z-score: 273.7 E(): 7.2e-08 26.5%25 identity in 181 aa overlap. Contains a 3xSRQ 1x SGQ repeat region in the N-terminus gene gene1407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1418 SCO1419 SCO1419 SC6D7.20c SC6D7.20c 1514933 1515700 + phosphodiesterase SC6D7.20c%2C phosphodiesterase%2C len: 255 aa. Similar to several including Escherichia coli SW:UGPQ_ECOLI(EMBL:X14437) glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) (247 aa)%2C fasta scores opt: 215 z-score: 267.5 E(): 1.6e-07 27.0%25 identity in 252 aa overlap and Mycobacterium tuberculosis TR:O07244(EMBL:Z96800) hypothetical 28.3 KD protein (256 aa)%2C fasta scores opt: 632 z-score: 771.7 E(): 0 44.2%25 identity in 251 aa overlap. gene gene1408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1419 SCO1420 SCO1420 SC6D7.19c SC6D7.19c 1515752 1517212 + hypothetical protein SC6D7.19c%2C possible integral membrane protein%2C len: 486 aa. Similar to several including: Bacillus subtilis SW:YXIO_BACSU(EMBL:D83026) hypothetical 47.3 KD protein (428 aa)%2C fasta scores opt: 735 z-score: 858.7 E():0 29.7%25 identity in 434 aa overlap and Mycobacterium leprae TR:O07710(EMBL:Z97179) hypothetical 48.7 KD protein (464 aa)%2C fasta scores opt: 327 z-score: 383.0 E(): 5.9e-14 29.7%25 identity in 445 aa overlap. Contains a TTA /leucine codon%2C possible target for bldA regulation and multiple possible membrane spanning hydrophobic domains. gene gene1409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1420 SCO1421 SCO1421 SC6D7.18c SC6D7.18c 1517384 1517758 + hypothetical protein SC6D7.18c%2C unknown%2C len: 124 aa. Highly similar to several including: Streptomyces coelicolor TR:Q9Z522(EMBL:AL035591) electron transport protein SCC54.03C (111 aa)%2C fasta scores opt: 223 z-score: 290.6 E(): 8.2e-09 33.6%25 identity in 107 aa overlap and Mycobacterium tuberculosis TR:O53492(EMBL:AL021899) hypothetical 13.0 KD protein (111 aa)%2C fasta scores opt: 426 z-score: 539.6 E(): 1.1e-22 57.4%25 identity in 108 aa overlap. gene gene1410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1421 SCO1422 SCO1422 SC6D7.17 SC6D7.17 1517861 1518445 - hypothetical protein SC6D7.17%2C possible membrane protein%2C len: 194 aa. Contains possible membrane spanning hydrophobic domains. gene gene1411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1422 SCO1423 SCO1423 SC6D7.16 SC6D7.16 1518492 1519400 - glycosyl transferase SC6D7.16%2C possible glycosyl transferase%2C len: 302 aa. Similar to many eukaryotic dolichol-phosphate-mannose synthases e.g. Mus musculus (Mouse) TR:O70152 (EMBL:AB004789) (260 aa)%2C fasta scores opt: 474 z-score: 560.2 E(): 7.9e-24 37.9%25 identity in 227 aa overlap. Also similar to a number of Prokaryotic proteins of undefined function e.g. Mycobacterium leprae TR:O32929 (EMBL:Z98604) hypothetical 30.1 KD protein (277 aa)%2C fasta scores opt: 917 z-score: 1076.0 E():0 52.0%25 identity in 281 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases. gene gene1412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1423 SCO1424 SCO1424 SC6D7.15 SC6D7.15 1519926 1521536 - hypothetical protein SC6D7.15%2C unknown%2C len: 536 aa. Highly similar to a protein of undefined function from Mycobacterium tuberculosis TR:O53494(EMBL:AL021899) hypothetical 55.9 KD protein (534 aa)%2C fasta scores opt: 1708 z-score: 1846.6 E():0 53.7%25 identity in 534 aa overlap. gene gene1413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1424 SCO1425 SCO1425 SC6D7.14 SC6D7.14 1521620 1522117 - transcription regulator AsnC SC6D7.14%2C possible AsnC-family transcriptional regulatory protein%2C len: 165 aa. Highly similar to several proteins of unknown function and to the Lrp (leucine-responsive regulatory protein) global regulatory proteins e.g. Escherichia coli SW:LRP_ECOLI(EMBL:M35869) leucine-responsive regulatory protein (163 aa)%2C fasta scores opt: 283 z-score: 348.1 E(): 5.2e-12 37.1%25 identity in 140 aa overlap and Mycobacterium tuberculosis TR:P96896(EMBL:Z92771) hypothetical 16.5 KD protein (150 aa)%2C fasta scores opt: 503 z-score: 608.4 E(): 1.6e-26 50.3%25 identity in 143 aa overlap. Contains a Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and a Prosite hit to PS00519 Bacterial regulatory proteins%2C asnC family signature. Contains a helix-turn-helix motif between residues 38..59 (+4.53 SD). gene gene1414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1425 SCO1426 SCO1426 SC6D7.13c SC6D7.13c 1522328 1522765 + hypothetical protein SC6D7.13c%2C unknown%2C len: 145 aa. gene gene1415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1426 SCO1427 SCO1427 SC6D7.12c SC6D7.12c 1522938 1523255 + hypothetical protein SC6D7.12c%2C unknown%2C len: 105 aa. gene gene1416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1427 SCO1428 SCO1428 acd acd 1523218 1524393 - acyl-CoA dehydrogenase SC6D7.11%2C acd%2C acyl-CoA dehydrogenase (EC 1.3.99.-)%2C len: 391 aa. Highly similar to many Prokaryotic and eukaryotic acyl-CoA dehydrogenases including: Megasphaera elsdenii SW:ACDS_MEGEL(EMBL:L04528) acyl-CoA dehydrogenase%2C short-chain specific (EC 1.3.99.2) (383 aa)%2C fasta scores opt: 926 z-score: 1026.2 E():0 40.9%25 identity in 372 aa overlap and Homo sapiens (Human) SW:ACDS_HUMAN(EMBL:M26393) acyl-CoA dehydrogenase%2C short-chain precursor (EC 1.3.99.2) (412 aa%2C fasta scores opt: 924 z-score: 1023.5 E():0 41.2%25 identity in 376 aa overlap. Also similar to Streptomyces coelicolor TR:CAB46799(EMBL:AL096811) acyl-CoA dehydrogenase SCI30A.22C (383 aa)%2C fasta scores opt: 940 z-score: 1041.6 E(): 0 41.1%25 identity in 375 aa overlap. Contains a Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and a Prosite hit to PS00073 Acyl-CoA dehydrogenases signature 2. gene gene1417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1428 SCO1429 SCO1429 chiD chiD 1524785 1526038 + chitinase SC6D7.10%2C chiD%2C chitinase (hypothetical protein)%2C len: 417 aa. Previously sequenced and characterised TR:Q9Z9M7(EMBL:AB017011) fasta scores opt: 2877 z-score: 3125.2 E():0 100.0%25 identity in 417 aa overlap. Contains a Pfam match to entry PF00704 Glyco_hydro_18%2C Glycosyl hydrolases family 18 and a Prosite hit to PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence gene gene1418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1429 SCO1430 SCO1430 SC6D7.09 SC6D7.09 1526117 1526779 - TetR family transcriptional regulator SC6D7.09%2C possible TetR-family transcriptional regulator%2C len: 220 aa. Weakly similar to several regulatory proteins e.g. Streptomyces coelicolor TR:CAB55659(EMBL:AL117385) tetR-family transcriptional regulator SC5G9.11C (197 aa)%2C fasta scores opt: 164 z-score: 201.8 E(): 0.00073 26.2%25 identity in 145 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 44..65 (+3.74 SD). gene gene1419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1430 SCO1431 SCO1431 SC6D7.08 SC6D7.08 1526862 1527104 - hypothetical protein SC6D7.08%2C possible membrane protein%2C len: 80 aa. Contains a possible membrane spanning hydrophobic domain. gene gene1420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1431 SCO1432 SCO1432 SC6D7.07 SC6D7.07 1527125 1528564 - hypothetical protein SC6D7.07%2C possible membrane protein%2C len: 479 aa. Contains a possible membrane spanning hydrophobic domain. gene gene1421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1432 SCO1433 SCO1433 SC6D7.06c SC6D7.06c 1528839 1529303 + hypothetical protein SC6D7.06c%2C doubtful CDS%2C len: 154 aa. gene gene1422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1433 SCO1434 SCO1434 SC6D7.05c SC6D7.05c 1529751 1531607 + CbxX/CfqX family protein SC6D7.05c%2C possible CbxX/CfqX family protein%2C len: 618 aa. Similar to several proteins of unknown function e.g. Mycobacterium tuberculosis TR:O69733(EMBL:AL022120) hypothetical 62.4 KD protein (573 aa)%2Cfasta scores opt: 751 z-score: 757.0 E():0 31.0%25 identity in 590 aa overlap. The C-terminus is similar to many proteins of the CbxX/CfqX family e.g. Bacillus subtilis SW:SP5K_BACSU(EMBL:X59412) stage V sporulation protein K (322 aa)%2C fasta scores opt: 645 z-score: 654.4 E(): 4.5e-29 39.6%25 identity in 280 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a TTA /leucine codon%2C possible target for bldA regulation. gene gene1423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1434 SCO1435 SCO1435 SC6D7.04 SC6D7.04 1531792 1532835 - hypothetical protein SC6D7.04%2C possible integral membrane protein%2C len: 347 aa. Highly similar to many proteins of unknown function including: Mycobacterium tuberculosis SW:YI41_MYCTU (EMBL:Z83859) hypothetical 36.7 KD protein (345 aa)%2C fasta scores opt: 884 z-score: 1036.1 E(): 0 43.8%25 identity in 349 aa overlap and Streptomyces coelicolor TR:CAB53285 (EMBL:AL109972) integral membrane protein SCJ9A.24C (339 aa)%2C fasta scores: opt: 705 z-score: 827.6 E():0 36.1%25 identity in 327 aa overlap. Also similar to the adjoining CDS SC6D7.03 (443 aa)%2C fasta scores: opt: 651 z-score: 666.6 E(): 8.9e-32 36.6%25 identity in 344 aa overlap. Contains a Pfam matches to entries PF01595 DUF21%2C Domain of unknown function and 2x Pfam match to entry PF00571 CBS%2C CBS domain. Also contains a possible N-terminal signal sequence and possible membrane spanning hydrophobic domains gene gene1424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1435 SCO1436 SCO1436 SC6D7.03 SC6D7.03 1532832 1534163 - hypothetical protein SC6D7.03%2C possible hypothetical protein%2C len: 443 aa. Highly similar to many proteins of unknown function including: Mycobacterium tuberculosis SW:Y0D3_MYCTU(EMBL:Z78020) hypothetical 36.7 KD protein (345 aa)%2C fasta scores opt: 1088 z-score: 1211.2 E():0 44.1%25 identity in 447 aa overlap and Streptomyces coelicolor TR:CAB53286(EMBL:AL109972) integral membrane protein SCJ9A.25C (445 aa)%2C fast scores opt: 1023 z-score: 1139.2 E():0 42.4%25 identity in 429 aa overlap. Also similar to the adjoining CDS SC6D7.04 (347 aa)%2C fasta scores opt: 651 z-score: 585.4 E(): 3e-27 35.9%25 identity in 343 aa overlap. Contains a Pfam matches to entries PF01595 DUF21%2C Domain of unknown function and 2x Pfam match to entry PF00571 CBS%2C CBS domain. Also contains possible hydrophobic membrane spanning regions gene gene1425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1436 SCO1437 SCO1437 SC6D7.02 SC6D7.02 1534368 1534838 - hypothetical protein SC6D7.02%2C possible membrane protein%2C len: 156 aa. Weakly similar to a hypothetical protein from Mycobacterium tuberculosis: SW:YE17_MYCTU(EMBL:Z80108) (154 aa)%2C fasta scores opt: 212 z-score: 266.9 E(): 1.7e-07 32.4%25 identity in 136 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene1426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1437 SCO1438 SCO1438 hisG hisG 1534876 1535733 - ATP phosphoribosyltransferase long form of enzyme%3B catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate%3B crucial role in histidine biosynthesis%3B forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors gene gene1427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1438 SCO1439 SCO1439 hisE hisE 1535782 1536054 - phosphoribosyl-ATP pyrophosphatase catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis gene gene1428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1439 SCO1440 SCO1440 ribH ribH 1536089 1536574 - 6%2C7-dimethyl-8-ribityllumazine synthase RibE%3B 6%2C7-diimethyl-8-ribityllumazine synthase%3B DMRL synthase%3B lumazine synthase%3B beta subunit of riboflavin synthase%3B condenses 5-amino-6-(1'-D)-ribityl-amino-2%2C4(1H%2C3H)-pyrimidinedione with L-3%2C4-dihydrohy-2-butanone-4-phosphate to generate 6%2C6-dimethyl-8-lumazine (DMRL)%3B riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12)%3B involved in the last steps of riboflavin biosynthesis%3B forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli%3B in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not gene gene1429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1440 SCO1441 SCO1441 ribAB ribAB 1536596 1537885 - bifunctional 3%2C4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein bifunctional enzyme DHBP synthase/GTP cyclohydrolase II%3B functions in riboflavin synthesis%3B converts GTP to 2%2C5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine%3B converts ribulose 5-phopshate to 3%2C4-dihydroxy-2-butanone 4-phosphate gene gene1430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1441 SCO1442 SCO1442 SC6D7A.05c SC6D7A.05c 1537882 1538526 - hypothetical protein SC6D7A.05c%2C possible integral membrane protein%2C len: 214 aa. Contains possible hydrophobic membrane spanning regions gene gene1431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1442 SCO1443 SCO1443 SC6D7A.06c SC6D7A.06c 1538523 1539125 - riboflavin synthase subunit alpha catalyzes the formation of riboflavin from 6%2C7-dimethyl-8-(1-D-ribityl)lumazine gene gene1432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1443 SCO1444 SCO1444 SCL6.01 SCL6.01 1539609 1541984 + chitinase SCL6.01%2C probable chitinase precursor%2C len: 791 aa%3B similar to TR:CAB62382 (EMBL:AJ250585) Arthrobacter sp chitinase precursor (EC 3.2.1.14) ChitIA%2C 880 aa%3B fasta scores: opt: 2788 z-score: 2817.6 E(): 0%3B 56.3%25 identity in 764 aa overlap and to SW:CHID_VIBFU (EMBL:U41418) Vibrio furnissii chitodextrinase precursor (EC 3.2.1.14) EndoI%2C 1046 aa%3B fasta scores: opt: 2055 z-score: 2075.7 E(): 0%3B 53.8%25 identity in 746 aa overlap. Contains three Pfam matches to entry PF00704 Glyco_hydro_18%2C Glycosyl hydrolases family 18 and match to Prosite entry PS01095 Chitinases family 18 active site. Contains also possible N-terminal region signal peptide sequence gene gene1433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1444 SCO1445 SCO1445 SCL6.02 SCL6.02 1542226 1542993 + hypothetical protein SCL6.02%2C hypothetical protein%2C len: aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB52958 (EMBL:AL109950) Streptomyces coelicolor hypothetical 25.2 kD protein%2C SCJ4.24c%2C 242 aa%3B fasta scores: opt: 424 z-score: 482.7 E(): 1.8e-19%3B 39.9%25 identity in 218 aa overlap and to TR:Q9EWF2 (EMBL:AL451182) Streptomyces coelicolor hypothetical protein SCK13.32c%2C 263 aa%3B fasta scores: opt: 711 Z-score: 779.3 E(): 8.9e-36%3B 49.407%25 identity in 253 aa overlap gene gene1434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1445 SCO1446 SCO1446 SCL6.03 SCL6.03 1543064 1543432 + hypothetical protein SCL6.03%2C possible integral membrane protein%2C len: 122 aa. Contains possible hydrophobic membrane spanning regions gene gene1435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1446 SCO1447 SCO1447 SCL6.04c SCL6.04c 1543454 1544653 - transcriptional regulator SCL6.04c%2C possible ROK-family transcriptional regulatory protein%2C len: 399 aa%3B similar to TR:CAB71832 (EMBL:AL138662) Streptomyces coelicolor ROK-family regulatory protein SC8E4A.27%2C 409 aa%3B fasta scores: opt: 938 z-score: 965.1 E(): 0%3B 42.5%25 identity in 398 aa overlap and to SW:XYLR_ANATH (EMBL:Z69782) Anaerocellum thermophilum xylose repressor XylR%2C 399 aa%3B fasta scores: opt: 327 z-score: 341.8 E(): 1.3e-1%3B 22.2%25 identity in 397 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and possible helix-turn-helix motif at residues 26..47 (+2.84 SD) gene gene1436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1447 SCO1448 SCO1448 SCL6.05 SCL6.05 1544766 1545977 + transporter SCL6.05%2C probable transport protein%2C len: 403 aa%3B similar to TR:AAF12043 (EMBL:AE002079) Deinococcus radiodurans transport protein%2C DR2502%2C 471 aa%3B fasta scores: opt: 687 z-score: 761.8 E(): 0%3B 39.0%25 identity in 359 aa overlap and to SW:MOSC_RHIME (EMBL:L17071) Rhizobium meliloti membrane protein MosC%2C 407 aa%3B fasta scores: opt: 496 z-score: 552.3 E(): 2.4e-23%3B 31.0%25 identity in 378 aa overlap. Contains match to Prosite entry PS00217 Sugar transport proteins signature 2. Contains also possible hydrophobic membrane spanning regions gene gene1437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1448 SCO1449 SCO1449 SCL6.06c SCL6.06c 1545937 1546395 - hypothetical protein SCL6.06c%2C hypothetical protein%2C len: 152 aa%3B similar to SW:YBGC_ECOLI (EMBL:M16489) Escherichia coli hypothetical 15.6 kD protein in CydB-TolQ intergenic region YbgC%2C 134 aa%3B fasta scores: opt: 140 z-score: 193.8 E(): 0.0023%3B 26.7%25 identity in 116 aa overlap gene gene1438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1449 SCO1450 SCO1450 SCL6.07 SCL6.07 1546564 1548000 + uracyl permease SCL6.07%2C probable uracyl permease%2C len: 478 aa%3B similar to TR:BAA35783 (EMBL:D90738) Escherichia coli uracil transport protein PyrP%2C 442 aa%3B fasta scores: opt: 908 z-score: 949.9 E(): 0%3B 43.1%25 identity in 429 aa overlap and to SW:PYRP_BACCL (EMBL:X76083) Bacillus caldolyticus uracil permease (uracil transporter) PyrP%2C 432 aa%3B fasta scores: opt: 770 z-score: 806.6 E(): 0%3B 33.0%25 identity in 437 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease%2C Xanthine/uracil permeases family. Contains also possible hydrophobic membrane spanning regions gene gene1439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1450 SCO1451 SCO1451 SCL6.08c SCL6.08c 1547982 1549133 - endoglucanase SCL6.08c%2C probable endoglucanase precursor%2C len: 383 aa%3B similar to SW:GUN1_STRSQ (EMBL:L03218) Streptomyces sp. endoglucanase 1 precursor (EC 3.2.1.4) CasA%2C 359 aa%3B fasta scores: opt: 1042 z-score: 1000.3 E(): 0%3B 50.6%25 identity in 324 aa overlap. Contains Pfam match to entry PF01341 Glyco_hydro_6%2C Glycosyl hydrolases family 6 and possible N-terminal region signal peptide sequence gene gene1440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1451 SCO1452 SCO1452 SCL6.09 SCL6.09 1549307 1550002 + hypothetical protein SCL6.09%2C unknown%2C len: 231 aa gene gene1441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1452 SCO1453 SCO1453 SCL6.10 SCL6.10 1550134 1551066 + hypothetical protein SCL6.10%2C conserved hypothetical protein%2C len: 310 aa%3B similar to various hypothetical proteins%2C e.g. SW:Y953_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 30.9 kD protein RV0953c%2C 282 aa%3B fasta scores: opt: 405 z-score: 467.1 E(): 1.4e-18%3B 33.6%25 identity in 265 aa overlap gene gene1442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1453 SCO1454 SCO1454 SCL6.11c SCL6.11c 1551086 1552783 - amino oxidase SCL6.11c%2C possible amino oxidase%2C len: 565 aa%3B similar to C-terminal region of SW:TR2M_AGRVI (EMBL:M91609) Agrobacterium vitis tryptophan 2-monooxygenase (EC 1.13.12.3) IaaM (auxins biosynthesis)%2C 723 aa%3B fasta scores: opt: 617 z-score: 725.3 E(): 5.6e-33%3B 30.9%25 identity in 557 aa overlap. Contains Pfam match to entry PF01593 Amino_oxidase%2C Flavin containing amine oxidase gene gene1443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1454 SCO1455 SCO1455 SCL6.12c SCL6.12c 1552848 1553636 - hydrolase SCL6.12c%2C possible hydrolase%2C len: 262 aa%3B similar to TR:O69808 (EMBL:AL023496) Streptomyces coelicolor hydrolase SC1A6.03%2C 280 aa%3B fasta scores: opt: 389 z-score: 454.5 E(): 6.8e-18%3B 31.2%25 identity in 276 aa overlap. Contains Pfam match to entry PF00795 CN_hydrolase%2C Carbon-nitrogen hydrolase and match to Prosite entry PS01227 Uncharacterized protein family UPF0012 signature gene gene1444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1455 SCO1456 SCO1456 SCL6.13c SCL6.13c 1553815 1554174 - hypothetical protein SCL6.13c%2C unknown%2C len: 119 aa gene gene1445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1456 SCO1457 SCO1457 SCL6.14c SCL6.14c 1554266 1555507 - transporter SCL6.14c%2C probable transport protein%2C len: 413 aa%3B similar to SW:MALA_BACST (EMBL:L13418) Bacillus stearothermophilus maltose permease MalA%2C 394 aa%3B fasta scores: opt: 221 z-score: 243.2 E(): 4e-06%3B 28.4%25 identity in 391 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1457 SCO1458 SCO1458 SCL6.15c SCL6.15c 1555656 1556108 - transcription regulator AsnC SCL6.15c%2C probable asnC-family regulatory protein%2C len: 150 aa%3B similar to SW:ASNC_HAEIN (EMBL:U32738) Haemophilus influenzae regulatory protein AsnC%2C 150 aa%3B fasta scores: opt: 229 z-score: 298.6 E(): 3.3e-09%3B 28.0%25 identity in 143 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and match ot Prostie entry PS00519 Bacterial regulatory proteins%2C asnC family signature and possible helix-turn-helix motif at residues 19..40 (+3.26 SD) gene gene1447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1458 SCO1459 SCO1459 SCL6.16c SCL6.16c 1556124 1557614 - amino acid transporter SCL6.16c%2C possible amino acid transporter%2C len: 496 aa%3B similar to TR:CAB63187 (EMBL:AL133469) Streptomyces coelicolor amino acid transporter SCM10.26%2C 468 aa%3B fasta scores: opt: 1245 z-score: 1366.2 E(): 0%3B 44.7%25 identity in 463 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and possible hydrophobic membrane spanning regions gene gene1448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1459 SCO1460 SCO1460 SCL6.17c SCL6.17c 1557912 1558307 - hypothetical protein SCL6.17c%2C unknown%2C len: 131 aa gene gene1449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1460 SCO1461 SCO1461 guaB2 guaB2 1558380 1559831 - inosine 5-monophosphate dehydrogenase catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate gene gene1450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1461 SCO1462 SCO1462 SCL6.19c SCL6.19c 1559931 1560284 - hypothetical protein SCL6.19c%2C unknown%2C len: 117 aa gene gene1451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1462 SCO1463 SCO1463 SCL6.20c SCL6.20c 1560350 1561432 - transcriptional regulator SCL6.20c%2C probable transcriptional regulator%2C len: 360 aa%3B similar to SW:DEOR_BACSU (EMBL:X82174) Bacillus subtilis deoxyribonucleoside regulator DeoR%2C 313 aa %3Bfasta scores: opt: 363 z-score: 408.8 E(): 2.4e-15%3B 28.0%25 identity in 307 aa overlap. Contains possible helix-turn-helix motif at residues 54..75 (+4.15 SD) gene gene1452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1463 SCO1464 SCO1464 rpe rpe 1561471 1562157 - ribulose-phosphate 3-epimerase catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate gene gene1453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1464 SCO1465 SCO1465 SCL6.22c SCL6.22c 1562315 1563520 - hypothetical protein SCL6.22c%2C possible hypothetical protein%2C len: 401 aa%3B similar to TR:Q55471 (EMBL:D64006) Synechocystis sp. hypothetical 46.5 kD protein%2C 421 aa%3B fasta scores: opt: 240 z-score: 260.1 E(): 4.6e-07%3B 28.8%25 identity in 385 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1465 SCO1466 SCO1466 SCL6.23c SCL6.23c 1563517 1564455 - hypothetical protein SCL6.23c%2C possible integral membrane protein%2C len: 312 aa. Contains possible hydrophobic membrane spanning regions gene gene1455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1466 SCO1467 SCO1467 SCL6.24c SCL6.24c 1564452 1565927 - hypothetical protein SCL6.24c%2C hypothetical protein%2C len: 491 aa%3B similar to TR:CAB71206 (EMBL:AL138538) Streptomyces coelicolor hypothetical 47.0 kD protein SC6D10.11%2C 452 aa%3B fasta scores: opt: 835 z-score: 861.3 E(): 0%3B 37.6%25 identity in 434 aa overlap gene gene1456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1467 SCO1468 SCO1468 SCL6.25c SCL6.25c 1565986 1568310 - Ser/Thr protein kinase SCL6.25c%2C possible Ser/Thr protein kinase%2C len: 774 aa%3B similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae Ser/Thr kinase MLCB1450.19c%2C 763 aa%3B fasta scores: opt: 682 z-score: 645.1 E(): 1.6e-28%3B 36.0%25 identity in 736 aa overlap and to SW:KMOS_MSVMO (EMBL:V01180) Moloney murine sarcoma virus MOS Ser/Thr protein kinase transforming protein (EC 2.7.1.-) V-MOS%2C 374 aa%3B fasta scores: opt: 230 z-score: 224.5 E(): 4.4e-05%3B 23.4%25 identity in 269 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain gene gene1457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1468 SCO1469 SCO1469 SCL6.26c SCL6.26c 1568408 1570513 - hypothetical protein SCL6.26c%2C unknown%2C len: 701 aa. C-terminal region rich in Glycine and Alanine residues. Contains Pfam match to entry PF00089 trypsin%2C Trypsin gene gene1458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1469 SCO1470 SCO1470 SCL6.27 SCL6.27 1570514 1570885 + hypothetical protein SCL6.27%2C hypothetical protein%2C len: 123 aa%3B similar to TR:Q53804 (EMBL:X73563) Streptomyces bambergiensis plasmid genes tra1 - tra5 and ORF4 and ORF7. Plasmid pBL1%2C 109 aa%3B fasta scores: opt: 134 z-score: 180.1 E(): 0.013%3B 31.1%25 identity in 74 aa overlap gene gene1459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1470 SCO1471 SCO1471 SCL6.28 SCL6.28 1570932 1571951 + transposase SCL6.28%2C transposase%2C len: 339 aa%3B identical to TR:CAB71807 (EMBL:AL138662) Streptomyces coelicolor transposase SC8E4A.02%2C 339 aa gene gene1460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1471 SCO1472 SCO1472 SCL6.29c SCL6.29c 1571971 1573398 - Sun-family protein SCL6.29c%2C conserved hypothetical Sun-family protein%2C len: 475 aa%3B similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein%2C 447 aa%3B fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32%3B 32.0%25 identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB%2C NusB family and to entry PF01189 Nol1_Nop2_Sun%2C NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature gene gene1461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1472 SCO1473 SCO1473 fmt fmt 1573487 1574419 - methionyl-tRNA formyltransferase modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation%3B inactivation of this gene in Escherichia coli severely impairs growth gene gene1462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1473 SCO1474 SCO1474 SCL6.31 SCL6.31 1574728 1575279 + hypothetical protein SCL6.31%2C unknown%2C len: 183 aa gene gene1463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1474 SCO1475 SCO1475 SCL6.32c SCL6.32c 1575452 1577602 - primosome assembly protein PriA binding of PriA to forked DNA starts the assembly of the primosome%2C also possesses 3'-5' helicase activity gene gene1464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1475 SCO1476 SCO1476 metK metK 1577727 1578935 - S-adenosylmethionine synthetase catalyzes the formation of S-adenosylmethionine from methionine and ATP%3B methionine adenosyltransferase gene gene1465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1476 SCO1477 SCO1477 SC9C5.01c SC9C5.01c 1579175 1580458 - bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C which is then decarboxylated to form 4'-phosphopantotheine gene gene1466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1477 SCO1478 SCO1478 SC9C5.02c SC9C5.02c 1580546 1580818 - DNA-directed RNA polymerase subunit omega Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits gene gene1467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1478 SCO1479 SCO1479 gmk gmk 1580881 1581474 - guanylate kinase Essential for recycling GMP and indirectly%2C cGMP gene gene1468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1479 SCO1480 SCO1480 SC9C5.04c SC9C5.04c 1581512 1581835 - hypothetical protein SC9C5.04c%2C conserved hypothetical protein%2C len: 107 aa%3B highly similar to TR:P96802 (EMBL:U75344) Mycobacterium smegmatis integration host factor MihF%2C 105 aa%3B fasta scores: opt: 378 z-score: 470.3 E(): 1e-1%3B 58.1%25 identity in 105 aa overlap gene gene1469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1480 SCO1481 SCO1481 pyrF pyrF 1582059 1582895 - orotidine 5'-phosphate decarboxylase type 2 subfamily%3B involved in last step of pyrimidine biosynthesis%3B converts orotidine 5'-phosphate to UMP and carbon dioxide%3B OMP decarboxylase%3B OMPDCase%3B OMPdecase gene gene1470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1481 SCO1482 SCO1482 pyrD pyrD 1582901 1584007 - dihydroorotate dehydrogenase 2 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway%3B uses a flavin nucleotide as an essential cofactor%3B class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus%2C which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors gene gene1471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1482 SCO1483 SCO1483 carB carB 1584104 1587412 - carbamoyl phosphate synthase large subunit four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate%3B CarB is responsible for the amidotransferase activity gene gene1472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1483 SCO1484 SCO1484 pyrAA pyrAA 1587405 1588547 - carbamoyl phosphate synthase small subunit catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways%3B forms an octamer composed of four CarAB dimers gene gene1473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1484 SCO1485 SCO1485 SC9C5.09c SC9C5.09c 1588544 1589119 - hypothetical protein SC9C5.09c%2C possible integral membrane protein%2C len: 191 aa%3B similar to TR:P71810 (EMBL:Z81011) Mycobacterium tuberculosis hypothetical 18.2 kD protein%2C 165 aa%3B fasta scores: opt: 301 z-score: 362.9 E(): 9.7e-13%3B 33.1%25 identity in 148 aa overlap. Contains possible hydrophobic membrane spanning region gene gene1474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1485 SCO1486 SCO1486 pyrC pyrC 1589116 1590402 - dihydroorotase catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis gene gene1475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1486 SCO1487 SCO1487 pyrB pyrB 1590407 1591387 - aspartate carbamoyltransferase catalytic subunit catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis gene gene1476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1487 SCO1488 SCO1488 pyrR pyrR 1591502 1592083 - bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes%2C also has been shown to have uracil phosphoribosyltransferase activity gene gene1477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1488 SCO1489 SCO1489 bldD bldD 1592381 1592884 + DNA-binding protein SC9C5.13%2C bldD%2C DNA-binding protein%2C len: 167 aa%3B identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor DNA binding protein BldD%2C 167 aa. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix gene gene1478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1489 SCO1490 SCO1490 nusB nusB 1593088 1593516 - transcription antitermination protein NusB Regulates rRNA biosynthesis by transcriptional antitermination gene gene1479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1490 SCO1491 SCO1491 efp efp 1593519 1594085 - elongation factor P Involved in peptide bond synthesis%3B alters the affinity of the ribosome for aminoacyl-tRNA gene gene1480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1491 SCO1492 SCO1492 SC9C5.16c SC9C5.16c 1594150 1595256 - peptidase SC9C5.16c%2C possible peptidase%2C len: 368 aa%3B similar to TR:Q9X842 (EMBL:AL049727) Streptomyces coelicolor dipeptidase SC9B1.23%2C 376 aa%3B fasta scores: opt: 552 z-score: 631.8 E(): 1e-27%3B 33.8%25 identity in 370 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24%2C metallopeptidase family M24 gene gene1481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1492 SCO1493 SCO1493 SC9C5.17c SC9C5.17c 1595436 1596323 - hypothetical protein SC9C5.17c%2C possible ATP/GTP binding protein ( hypothetical protein)%2C len:295 aa%3B similar to TR:Q9S4Q8 (EMBL:AF121009) Mycobacterium tuberculosis hypothetical 33.5 kD protein%2C 342 aa%3B fasta scores: opt: 307 z-score: 233.4 E(): 1.6e-05%3B 41.1%25 identity in 124 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains also degenerate 3x repeat: PAPAP(G/Q)PH at N-terminal domain and high content in proline amino acid residues. Contains possible N-terminal region signal peptide sequence gene gene1482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1493 SCO1494 SCO1494 aroB aroB 1596490 1597581 - 3-dehydroquinate synthase catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate%3B functions in aromatic amino acid biosynthesis gene gene1483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1494 SCO1495 SCO1495 aroK aroK 1597578 1598093 - shikimate kinase catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis gene gene1484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1495 SCO1496 SCO1496 aroF aroF 1598090 1599274 - chorismate synthase catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis gene gene1485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1496 SCO1497 SCO1497 SC9C5.21c SC9C5.21c 1599480 1599845 - hypothetical protein SC9C5.21c%2C possible integral membrane protein%2C len: 121 aa. Contains possible hydrophobic membrane spanning regions gene gene1486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1497 SCO1498 SCO1498 aroE aroE 1599894 1600733 - shikimate 5-dehydrogenase AroE%3B catalyzes the conversion of shikimate to 3-dehydroshikimate gene gene1487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1498 SCO1499 SCO1499 SC9C5.23c SC9C5.23c 1600714 1602462 - hypothetical protein SC9C5.23c%2C possible integral membrane protein%2C len: 582 aa. Contains possible hydrophobic membrane spanning region and degenerate repeat: 2x QDYQQQGY gene gene1488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1499 SCO1500 SCO1500 SC9C5.24c SC9C5.24c 1602591 1603094 - Holliday junction resolvase-like protein similar to RuvC resolvase with substantial differences%3B NMR structural information suggests this protein is monomeric%3B unknown cellular function gene gene1489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1500 SCO1501 SCO1501 alaS alaS 1603091 1605763 - alanyl-tRNA synthetase Catalyzes a two-step reaction%2C first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene1490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1501 SCO1502 SCO1502 SC9C5.26c SC9C5.26c 1605763 1606119 - hypothetical protein SC9C5.26c%2C possible hypothetical protein%2C len: 118 aa. Contains possible N-terminal signal peptide sequence gene gene1491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1502 SCO1503 SCO1503 SC9C5.27c SC9C5.27c 1606127 1606576 - hypothetical protein SC9C5.27c%2C possible hypothetical protein%2C len: 149 aa. Contains possible N-terminal region signal peptide sequence gene gene1492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1503 SCO1504 SCO1504 SC9C5.28 SC9C5.28 1606679 1608931 + regulator SC9C5.28%2C regulator%2C len: 750 aa%3B similar to TR:O53720 (EMBL:AL021931) Mycobacterium tuberculosis transcriptional regulatory protein MTV036.21%2C 1085 aa%3B fasta scores: opt: 975 z-score: 1090.3 E(): 0%3B 34.3%25 identity in 724 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1504 SCO1505 SCO1505 rpsD rpsD 1608976 1609590 - 30S ribosomal protein S4 primary rRNA binding protein%3B nucleates 30S assembly%3B involved in translational accuracy with proteins S5 and S12%3B interacts with protein S5%3B involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA%3B interacts with transcription complex and functions similar to protein NusA in antitermination gene gene1494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1505 SCO1506 SCO1506 SC9C5.30c SC9C5.30c 1609885 1611240 - recombination factor protein RarA SC9C5.30c%2C conserved ATP/GTP binding protein%2C len: 451 aa%3B similar to SW:Y0A9_MYCTU (EMBL:Z77250) Mycobacterium tuberculosis hypothetical 47.5 kD protein MTCY9C4.09%2C 452 aa%3B fasta scores: opt: 1742 z-score: 1796.7 E(): 0%3B 64.4%25 identity in 430 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1506 SCO1507 SCO1507 SC9C5.31c SC9C5.31c 1611310 1612032 - hypothetical protein SC9C5.31c%2C possible integral membrane protein%2C len: 240 aa%3B similar to TR:O69464 (EMBL:AL023635) Mycobacterium leprae integral membrane protein MLCB1243.07%2C 214 aa%3B fasta scores: opt: 511 z-score: 600.4 E(): 5.7e-26%3B 36.1%25 identity in 191 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1507 SCO1508 SCO1508 hisS hisS 1612166 1613443 - histidyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B class II aminoacyl-tRNA synthetase%3B forms homodimers%3B some organisms have a paralogous gene%2C hisZ%2C that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG gene gene1497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1508 SCO1509 SCO1509 SC9C5.33c SC9C5.33c 1613440 1614147 - hydrolase SC9C5.33c%2C possible hydrolase%2C len: 235 aa%3B similar to SW:YCBL_ECOLI (EMBL:AE000195) Escherichia coli hypothetical 23.8 kD protein in MukB-AspC intergenic region YcbL%2C 215 aa%3B fasta scores: opt: 284 z-score: 328.0 E(): 8.4e-11%3B 32.6%25 identity in 215 aa overlap and to TR:CAB83688 (EMBL:AL162753) Neisseria meningitidis hydrolase NMA0387%2C 210 aa%3B fasta scores: opt: 239 z-score: 277.9 E(): 5.2e-08%3B 32.5%25 identity in 206 aa overlap. Contains Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily gene gene1498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1509 SCO1510 SCO1510 SC9C5.34 SC9C5.34 1614331 1615164 + peptidyl-prolyl cis-trans isomerase SC9C5.34%2C possible peptidyl-prolyl cis-trans isomerase%2C len: 277 aa%3B similar to SW:CYPB_MYCLE (EMBL:U00011) Mycobacterium leprae probable peptidyl-prolyl cis-trans isomerase PpiB or MLCB1259.10c%2C 295 aa%3B fasta scores: opt: 514 z-score: 573.6 E(): 1.8e-24%3B 40.0%25 identity in 295 aa overlap and to SW:CYPB_BACSU (EMBL:L09228) Bacillus subtilis peptidyl-prolyl cis-trans isomerase PpiB%2C 143 aa%3B fasta scores: opt: 240 z-score: 276.9 E(): 5.9e-08%3B 37.0%25 identity in 127 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase%2C Cyclophilin type peptidyl-prolyl cis-trans isomerase. Contains also possible hydrophobic membrane spanning region gene gene1499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1510 SCO1511 SCO1511 SC9C5.35 SC9C5.35 1615300 1616367 + hypothetical protein SCL2.01%2C hypothetical protein (fragment)%2C len: >328 aa%3B similar to TR:O33236 (EMBL:Z98209) Mycobacterium tuberculosis hypothetical 49.8 kD protein MTCY174.11%2C len: 450 aa%3B fasta scores: opt: 843 z-score: 874.7 E(): 0%3B 45.9%25 identity in 296 aa overlap. Contains possible coiled-coils region~SC9C5.35%2C hypothetical protein (fragment)%2C len: >57 aa gene gene1500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1511 SCO1512 SCO1512 SCL2.02 SCL2.02 1616388 1616528 + hypothetical protein SCL2.02%2C unknown%2C len: 46 aa gene gene1501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1512 SCO1513 SCO1513 relA relA 1616607 1619150 - GTP pyrophosphokinase SCL2.03c%2C relA%2C GTP pyrophosphokinase%2C len: 847 aa%3B identical to previously sequenced SW:RELA_STRCO (EMBL:X87267) Streptomyces coelicolor GTP pyrophosphokinase (EC 2.7.6.5) RelA%2C 847 aa and highly similar to SW:RELA_STRAT (EMBL:AF072829) Streptomyces antibioticus RelA protein%2C 841 aa%3B fasta scores: opt: 4969 z-score: 4906.2 E(): 0%3B 90.3%25 identity in 848 aa overlap and to SW:RELA_CORGL (EMBL:AF038651) Corynebacterium glutamicum GTP pyrophosphokinase (EC 2.7.6.5) RelA%2C 760 aa%3B fasta scores: opt: 1613 z-score: 1594.3 E(): 0%3B 58.7%25 identity in 774 aa overlap. Contains Pfam match to entry PF01842 ACT%2C ACT domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1513 SCO1514 SCO1514 apt apt 1619334 1619831 - adenine phosphoribosyltransferase catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis gene gene1503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1514 SCO1515 SCO1515 secF secF 1619879 1621000 - preprotein translocase subunit SecF forms a complex with SecD and YajC%3B SecDFyajC stimulates the proton motive force-driven protein translocation%3B seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane%3B in some organisms%2C such as Bacillus subtilis%2C SecD is fused to SecF gene gene1504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1515 SCO1516 SCO1516 secD secD 1621004 1622716 - preprotein translocase subunit SecD part of the preprotein secretory system%3B when complexed with proteins SecF and YajC%2C SecDFyajC stimulates the proton motive force-driven protein translocation%2C and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane gene gene1505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1516 SCO1517 SCO1517 SCL2.07c SCL2.07c 1622951 1623460 - hypothetical protein SCL2.07c%2C possible hypothetical protein%2C len: 169 aa%3B similar to SW:YP88_MYCLE (EMBL:AL023591) Mycobacterium leprae hypothetical protein MCLB1259.04%2C 114 aa%3B fasta scores: opt: 205 z-score: 231.1 E(): 1.8e-05%3B 36.7%25 identity in 120 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1517 SCO1518 SCO1518 ruvB ruvB 1623636 1624709 - Holliday junction DNA helicase RuvB promotes strand exchange during homologous recombination%3B RuvAB complex promotes branch migration%3B RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences%3B forms hexameric rings around opposite DNA arms%3B requires ATP for branch migration and orientation of RuvAB complex determines direction of migration gene gene1507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1518 SCO1519 SCO1519 ruvA ruvA 1624756 1625361 - Holliday junction DNA helicase RuvA plays an essential role in ATP-dependent branch migration of the Holliday junction gene gene1508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1519 SCO1520 SCO1520 ruvC ruvC 1625358 1625924 - Holliday junction resolvase endonuclease%3B resolves Holliday structures%3B forms a complex of RuvABC%3B the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration%3B RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity gene gene1509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1520 SCO1521 SCO1521 SCL2.11c SCL2.11c 1626033 1626785 - hypothetical protein SCL2.11c%2C hypothetical protein%2C len: 250 aa%3B similar to various hypothetical proteins%2C e.g. TR:YQ03_MYCTU (EMBL:Z98045) Mycobacterium tuberculosis hypothetical 26.8 kD protein RV2603c%2C 251 aa%3B fasta scores: opt: 1268 z-score: 1388.1 E(): 0%3B 76.7%25 identity in 249 aa overlap. Contains Pfam match to entry PF01709 DUF28%2C Domain of unknown function gene gene1510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1521 SCO1522 SCO1522 SCL2.12c SCL2.12c 1626835 1627443 - glutamine amidotransferase subunit PdxT with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate%3B PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia%3B PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate gene gene1511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1522 SCO1523 SCO1523 SCL2.13c SCL2.13c 1627456 1628367 - pyridoxal biosynthesis lyase PdxS with PdxT forms pyridoxal 5'-phosphate from glutamine%2C either ribose 5-phosphate or ribulose 5-phosphate%2C and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate gene gene1512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1523 SCO1524 SCO1524 SCL2.14c SCL2.14c 1628479 1629021 - hypothetical protein SCL2.14c%2C membrane protein%2C len: 180 aa%3B similar to TR:O06205 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 38.1 Kd protein MTCY1A10.24%2C 351 aa%3B fasta scores: opt: 179 z-score: 211.7 E(): 0.00021%3B 43.3%25 identity in 171 aa overlap. Contains possible hydrophobic membrane spanning region gene gene1513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1524 SCO1525 SCO1525 SCL2.15c SCL2.15c 1629081 1630244 - sugar transferase SCL2.15c%2C possible sugar transferase%2C len: 387 aa%3B similar to TR:O28546 (EMBL:AE000983) Archaeoglobus fulgidus galactosyltransferase%2C 356 aa%3B fasta scores: opt: 422 z-score: 488.7 E(): 7.9e-20%3B 26.9%25 identity in 375 aa overlap and to TR:O06204 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 40.4 Kd protein MTCY1A10.23%2C 378 aa%3B fasta scores: opt: 1216 z-score: 1400.3 E(): 0%3B 52.7%25 identity in 376 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene1514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1525 SCO1526 SCO1526 SCL2.16c SCL2.16c 1630241 1631176 - lipid A biosynthesis lauroyl acyltransferase Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA gene gene1515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1526 SCO1527 SCO1527 SCL2.17c SCL2.17c 1631173 1631898 - membrane transferase SCL2.17c%2C possible membrane transferase%2C len: 241 aa%3B similar to TR:CAB50482 (EMBL:AJ248288) Pyrococcus abyssi CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA%2C 186 aa%3B fasta scores: opt: 286 z-score: 350.3 E(): 4e-12%3B 33.0%25 identity in 203 aa overlap and to TR:O06202 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 23.3 kD protein MTCY1A10.21%2C 217 aa%3B fasta scores: opt: 564 z-score: 679.1 E(): 2e-30%3B 43.4%25 identity in 212 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf%2C CDP-alcohol phosphatidyltransferase and match to Prosite entry PS00379 CDP-alcohol phosphatidyltransferases signature. Contains possible hydrophobic membrane spanning regions gene gene1516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1527 SCO1528 SCO1528 fusA fusA 1632106 1634304 + elongation factor G EF-G%3B promotes GTP-dependent translocation of the ribosome during translation%3B many organisms have multiple copies of this gene gene gene1517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1528 SCO1529 SCO1529 SCL2.19 SCL2.19 1634572 1636227 + hypothetical protein SCL2.19%2C possible membrane protein%2C len: 551 aa. Contains possible hydrophobic membrane spanning regions gene gene1518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1529 SCO1530 SCO1530 SCL2.20c SCL2.20c 1636316 1636876 - hypothetical protein SCL2.20c%2C hypothetical HIT family protein%2C len: 186 aa%3B similar to TR:O06201 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 21.8 kD protein MTCY01A10.20A%2C 195 aa%3B fasta scores: opt: 638 z-score: 762.0 E(): 0%3B 52.8%25 identity in 176 aa overlap and to TR:CAB48988 (EMBL:AJ248283) Pyrococcus abyssi HIT family protein%2C 185 aa%3B fasta scores: opt: 498 z-score: 597.6 E(): 6.8e-26%3B 45.1%25 identity in 164 aa overlap. similar also to TR:Q9F7Z0 (EMBL:AF265558) Mycobacterium smegmatis hypothetical protein 205 aa%3B fasta scores: opt: 653 Z-score: 762.7 E(): 7.5e-35%3B 52.432%25 identity in 185 aa overlap. Contains Pfam match to entry PF01230 HIT%2C HIT family gene gene1519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1530 SCO1531 SCO1531 thrS thrS 1636966 1638942 - threonyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) gene gene1520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1531 SCO1532 SCO1532 SCL2.22c SCL2.22c 1639131 1640408 - hypothetical protein SCL2.22c%2C hypothetical protein%2C len: 425 aa%3B similar to TR:Q9X4H6 (EMBL:AF110772) Streptomyces aureofaciens aldehyde dehydrogenase AldA%2C 467 aa%3B fasta scores: opt: 156 z-score: 162.9 E(): 0.11%3B 29.0%25 identity in 328 aa overlap gene gene1521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1532 SCO1533 SCO1533 SCL2.23c SCL2.23c 1640405 1640971 - hypothetical protein SCL2.23c%2C unknown%2C len: 188 aa gene gene1522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1533 SCO1534 SCO1534 SCL2.24 SCL2.24 1641143 1641868 + DNA polymerase III subunit epsilon 3'-5' exonuclease of DNA polymerase III gene gene1523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1534 SCO1535 SCO1535 SCL2.25c SCL2.25c 1642057 1642515 - hypothetical protein SCL2.25c%2C unknown%2C len: 152 aa gene gene1525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1535 SCO1536 SCO1536 SCL2.26c SCL2.26c 1642555 1645023 - hypothetical protein SCL2.26c%2C hypothetical protein%2C len: 822 aa%3B similar to TR:O31530 (EMBL:Z99107) Bacillus subtilis YetA PROTEIN%2C 857 aa%3B fasta scores: opt: 982 z-score: 1078.1 E(): 0%3B 35.1%25 identity in 840 aa overlap gene gene1526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1536 SCO1537 SCO1537 SCL2.27c SCL2.27c 1645999 1646910 - transport system membrane protein SCL2.27c%2C probable transport system membrane protein%2C len: 303 aa%3B similar to SW:YESQ_BACSU (EMBL:Z99107) Bacillus subtilis probable ABC transporter permease YesQ%2C 296 aa%3B fasta scores:opt: 868 z-score: 1048.4 E(): 0%3B 45.1%25 identity in 295 aa overlap and to TR:CAB59597 (EMBL:AL132662) Streptomyces coelicolor probable sugar transport inner membrane protein SCF11.20%2C 299 aa%3B fasta scores: opt: 636 z-score: 769.8 E(): 0%3B 37.7%25 identity in 308 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene1527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1537 SCO1538 SCO1538 SCL2.28c SCL2.28c 1646907 1647893 - transport system membrane protein SCL2.28c%2C probable transport system membrane protein%2C len: 328 aa%3B similar to SW:YESP_BACSU (EMBL:Z99107) Bacillus subtilis probable ABC transporter permease YesP%2C 309 aa%3B fasta scores: opt: 1013 z-score: 1146.0 E(): 0%3B 48.8%25 identity in 301 aa overlap and to TR:CAB59596 (EMBL:AL132662) Streptomyces coelicolor probable sugar transporter inner membrane protein SCF11.19%2C 316 aa%3B fasta scores: opt: 608 z-score: 690.8 E(): 4.4e-31%3B 32.8%25 identity in 320 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene1528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1538 SCO1539 SCO1539 SCL2.29c SCL2.29c 1647905 1649206 - lipoprotein SCL2.29c%2C possible hypothetical protein%2C len: 433 aa%3B similar to TR:O31518 (EMBL:Z99107) Bacillus subtilis YesO protein%2C 412 aa%3B fasta scores: opt: 606 z-score: 680.7 E(): 1.7e-30%3B 27.7%25 identity in 411 aa overlap and to TR:CAB59595 (EMBL:AL132662) Streptomyces coelicolor probable sugar transporter sugar binding lipoprotein SCF11.18%2C 442 aa%3B fasta scores: opt: 312 z-score: 352.1 E(): 3.4e-12%3B 24.4%25 identity in 454 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains N-terminal region signal peptide sequence gene gene1529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1539 SCO1540 SCO1540 SCL2.30c SCL2.30c 1649733 1650185 - hypothetical protein SCL2.30c%2C possible membrane protein%2C len: 150 aa%3B similar to SW:YAIZ_ECOLI (EMBL:AE000144) Escherichia coli hypothetical 13.0 kD protein YaiZ%2C 114 aa%3B fasta scores: opt: 121 z-score: 164.5 E(): 0.09%3B 31.0%25 identity in 71 aa overlap and to TR:CAB53332 (EMBL:AL109974) Streptomyces coelicolor membrane protein SCF34.21%2C 144 aa%3B fasta scores: opt: 117 z-score: 158.1 E(): 0.21%3B 23.9%25 identity in 92 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1540 SCO1541 SCO1541 SCL2.31 SCL2.31 1650311 1650790 + regulator SCL2.31%2C probable regulator%2C len: 159 aa%3B similar to various Streptomyces regulatory proteins%2C e.g. TR:CAB51005 (EMBL:AL096852) Streptomyces coelicolor regulator SCE19A.24%2C 142 aa%3B fasta scores: opt: 503 z-score: 661.7 E(): 1.8e-29%3B 57.9%25 identity in 133 aa overlap and TR:P95753 (EMBL:D50051) Streptomyces griseus SsgA%2C 136 aa%3B fasta scores: opt: 326 z-score: 433.9 E(): 8.9e-17%3B 43.1%25 identity in 130 aa overlap gene gene1532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1541 SCO1542 SCO1542 SCL2.32 SCL2.32 1651070 1651630 + hypothetical protein SCL2.32%2C hypothetical protein%2C len: 186 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB59700 (EMBL:AL132707) Streptomyces coelicolor hypothetical 21.7 kD protein SCF51.02c%2C 205 aa%3B fasta scores: opt: 188 z-score: 240.3 E(): 5.4e-06%3B 31.1%25 identity in 180 aa overlap gene gene1533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1542 SCO1543 SCO1543 SCL2.33c SCL2.33c 1652074 1652535 - hypothetical protein SCL2.33c%2C membrane protein%2C len: 153 aa. Contains possible hydrophobic membrane spanning regions gene gene1534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1543 SCO1544 SCO1544 SCL2.34 SCL2.34 1652664 1653251 + hypothetical protein SCL2.34%2C hypothetical protein%2C len: 195 aa%3B similar to TR:AAF10140 (EMBL:AE001914) Deinococcus radiodurans conserved hypothetical protein DR0560%2C 376 aa%3B fasta scores: opt: 248 z-score: 296.3 E(): 4.1e-09%3B 37.6%25 identity in 149 aa overlap gene gene1535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1544 SCO1545 SCO1545 SCL11.01c SCL11.01c 1653340 1654167 - acetyltransferase SCL11.01c%2C possible acetyltransferase%2C len: >81 aa%3B C-terminal part of TR:CAB70947 (EMBL:AL137778) S. coelicolor cosmid SCL2.35c acetyltransferase~SCL2.35c%2C possible acetyltransferase (partial)%2C len: >225 aa%3B similar to TR:CAB50578 (EMBL:AJ248288) Pyrococcus abyssi N-terminal acetyltransferase%2C 172 aa%3B fasta scores: opt: 164 z-score: 202.4 E(): 0.0007%3B 36.0%25 identity in 89 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1545 SCO1546 SCO1546 SCL11.02c SCL11.02c 1654295 1655116 - 4-amino-4-deoxychorismate lyase SCL11.02c%2C probable aminotransferase%2C len: 273 aa%3B similar to SW:DAAA_BACSU (EMBL:)Y14082 Bacillus subtilis D-alanine aminotransferase (EC 2.6.1.21) Dat%2C 282 aa%3B fasta scores: opt: 347 z-score: 415.1 E(): 1.1e-15%3B 28.5%25 identity in 274 aa overlap. Contains Pfam match to entry PF01063 aminotran_4%2C Aminotransferase class IV and match to Prosite entry PS00770 Aminotransferases class-IV signature gene gene1537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1546 SCO1547 SCO1547 SCL11.03c SCL11.03c 1655113 1656174 - anthranilate synthase SCL11.03c%2C possible anthranilate synthase%2C len: 353 aa%3B similar to SW:TRPE_THEMA (EMBL:X74075) Thermotoga maritima Anthranilate synthase component I (EC 4.1.3.27) TrpE%2C 457 aa%3B fasta scores: opt: 459 z-score: 510.1 E(): 5.4e-21%3B 37.2%25 identity in 285 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind%2C chorismate binding enzyme gene gene1538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1547 SCO1548 SCO1548 SCL11.04c SCL11.04c 1656870 1657130 - hypothetical protein SCL11.04c%2C unknown%2C len: 86 aa gene gene1544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1548 SCO1549 SCO1549 SCL11.05c SCL11.05c 1657259 1658197 - hypothetical protein SCL11.05c%2C hypothetical protein%2C len: 312 aa%3B similar to TR:O33744 (EMBL:Y10293) Streptomyces sp. hypothetical 33.8 kD protein 312 aa%3B fasta scores: opt: 206 z-score: 221.9 E(): 6.1e-05%3B 29.7%25 identity in 273 aa overlap gene gene1545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1549 SCO1550 SCO1550 SCL11.06c SCL11.06c 1658389 1658571 - small membrane protein SCL11.06c%2C possible small membrane protein%2C len: 60 aa. Contains possible hydrophobic membrane spanning regions gene gene1546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1550 SCO1551 SCO1551 SCL11.07 SCL11.07 1659144 1660625 + protein kinase SCL11.07%2C possible eukaryotic-type protein kinase%2C len: 493 aa%3B similar to TR:Q9ZN80 (EMBL:AB021679) Streptomyces coelicolor PkaG%2C 592 aa%3B fasta scores: opt: 926 z-score: 659.3 E(): 2.6e-29%3B 41.0%25 identity in 417 aa overlap and N-terminal region similar to SW:AFSK_STRGR0 (EMBL:D45246) Streptomyces griseus Ser/Thr protein kinase AfsK (EC 2.7.1.-) 807 aa%3B fasta scores: opt: 871 z-score: 619.6 E(): 4.3e-27%3B 39.3%25 identity in 435 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature. Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene1547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1551 SCO1552 SCO1552 SCL11.08c SCL11.08c 1660653 1661471 - rRNA methylase SCL11.08c%2C probable rRNA methylase%2C len: 272 aa%3B similar to SW:Y881_MYCTU (EMBL:Z73101) Mycobacterium tuberculosis hypothetical tRNA/rRNA methyltransferase RV0881 (EC 2.1.1.-)%2C 288 aa%3B fasta scores: opt: 726 z-score: 879.9 E(): 0%3B 45.2%25 identity in 259 aa overlap and to SW:TSNR_STRAZ (EMBL:X02392) Streptomyces azureus rRNA (adenosine-2'-O-)-mehtyltransferase (EC 2.1.1.66) TsnR%2C 269 aa%3B fasta scores: opt: 226 z-score: 279.3 E(): 3.9e-08%3B 29.0%25 identity in 269 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase%2C SpoU rRNA Methylase family gene gene1548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1552 SCO1553 SCO1553 SCL11.09c SCL11.09c 1661473 1662705 - uroporphyrin-III methyltransferase SCL11.09c%2C probable uroporphyrin-III methyltransferase%2C len: 410 aa%3B similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG%2C 405 aa%3B fasta scores: opt: 1487 z-score: 1630.7 E(): 0%3B 58.7%25 identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA%2C 238 aa%3B fasta scores: opt: 719 z-score: 794.9 E(): 0%3B 48.1%25 identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase signature 2 gene gene1549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1553 SCO1554 SCO1554 SCL11.10c SCL11.10c 1662892 1666530 - nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase SCL11.10c%2C nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase%2C len: 612 aa%3B N-terminal region similar to TR:O07233 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 24.9 kD protein%2C 223 aa%3B fasta scores: opt: 558 z-score: 594.0 E(): 1.1e-25%3B 42.3%25 identity in 222 aa overlap and C-terminal region similr to SW:COBT_ECOLI (EMBL:U33333) Escherichia coli nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) CobT%2C 359 aa%3B fasta scores: opt: 793 z-score: 837.6 E(): 0%3B 38.3%25 identity in 347 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase%2C Nitroreductase family gene gene1550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1554 SCO1555 SCO1555 SCL11.11c SCL11.11c 1666903 1668129 - methyltransferase SCL11.11c%2C probable methyltransferase%2C len: 408 aa%3B similar to TR:Q55879 (EMBL:D64004) Synechocystis sp. precorrin-6Y methylase CbiE%2C 425 aa%3B fasta scores: opt: 379 z-score: 405.5 E(): 3.6e-15%3B 29.9%25 identity in 354 aa overlap and to SW:CBIE_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-6Y C5%2C15-methyltransferase [decarboxylating] (EC 2.1.1.132) CbiE%2C 201 aa%3B fasta scores: opt: 250 z-score: 274.2 E(): 7.5e-08%3B 33.3%25 identity in 204 aa overlap. Contains Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases gene gene1551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1555 SCO1556 SCO1556 SCL11.12c SCL11.12c 1668247 1668945 - acetyltransferase SCL11.12c%2C possible acetyltransferase%2C len: 232 aa%3B similar to TR:CAB59477 (EMBL:AL132648) Streptomyces coelicolor acetyltransferase SCI41.07c%2C 196 aa%3B fasta scores: opt: 245 z-score: 310.5 E(): 7.1e-10%3B 33.7%25 identity in 175 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1556 SCO1557 SCO1557 SCL11.13c SCL11.13c 1669056 1669883 - lipoprotein SCL11.13c%2C possible lipoprotein%2C len: 275 aa%3B similar to TR:AAD51879 (EMBL:AF102556) Salmonella enteritidis liporpotein SfbA%2C 276 aa%3B fasta scores: opt: 519 z-score: 578.9 E(): 8e-25%3B 38.0%25 identity in 258 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene1553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1557 SCO1558 SCO1558 SCL11.14c SCL11.14c 1669950 1670672 - ABC transporter permease SCL11.14c%2C probable ABC transporter permease%2C len: 240 aa%3B similar to TR:AAF10929 (EMBL:AE001982) Deinococcus radiodurans ABC transporter%2C permease DR1357%2C 218 aa%3B fasta scores: opt: 721 z-score: 842.8 E(): 0%3B 57.7%25 identity in 213 aa overlap and to SW:PROW_BACSU (EMBL:U38418) Bacillus subtilis glycine/betaine/L-proline transport system permease ProW%2C 217 aa%3B fasta scores: opt: 212 z-score: 255.8 E(): 7.9e-07%3B 28.4%25 identity in 194 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component gene gene1554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1558 SCO1559 SCO1559 SCL11.15c SCL11.15c 1670684 1671790 - ABC transporter ATP-binding protein SCL11.15c%2C probable ABC transporter ATP-binding protein%2C len: 368 aa%3B similar to SW:ABC_ECOLI (EMBL:L08626) Escherichia coli ATP-binding protein Abc%2C 343 aa%3B fasta scores: opt: 909 z-score: 1006.2 E(): 0%3B 49.1%25 identity in 346 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporte and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene1555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1559 SCO1560 SCO1560 SCL11.16c SCL11.16c 1672166 1672816 - phosphatase SCL11.16c%2C possible phosphatase%2C len: 216 aa%3B similar to TR:P96428 (EMBL:Z79692) Sinorhizobium meliloti ORF24%2C 233 aa%3B fasta scores: opt: 488 z-score: 573.6 E(): 1.6e-24%3B 42.2%25 identity in 206 aa overlap and to TR:BAA16133 (EMBL:D90861)Escherichia coli 2-deoxyglucose-6-phosphate phosphatase 1 (EC 3.1.3.-) Dog1%2C 222aa%3B fasta scores: opt: 430 z-score: 507.0 E(): 8.1e-21%3B 36.2%25 identity in 213 aa overlap gene gene1556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1560 SCO1561 SCO1561 SCL11.17 SCL11.17 1672877 1673236 + hypothetical protein SCL11.17%2C possible integral membrane protein%2C len: 119 aa. Contains possible hydrophobic membrane spanning regions gene gene1557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1561 SCO1562 SCO1562 SCL11.18 SCL11.18 1673238 1673654 + hypothetical protein SCL11.18%2C possible integral membrane protein%2C len: 138 aa. Contains possible hydrophobic membrane spanning regions gene gene1558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1562 SCO1563 SCO1563 SCL11.19c SCL11.19c 1673718 1674203 - acetyltransferase SCL11.19c%2C possible acetyltransferase%2C len: 161 aa%3B similar to TR:O26873 (EMBL:AE000856) Methanobacterium thermoautotrophicum conserved protein Mth779%2C 170 aa%3B fasta scores: opt: 174 z-score: 231.8 E(): 1.7e-05%3B 28.8%25 identity in 125 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1563 SCO1564 SCO1564 SCL11.20c SCL11.20c 1674273 1674773 - RNA polymerase sigma factor SCL11.20c%2C possible RNA polymerase sigma factor ECF subfamily%2C len: 166 aa%3B similar to SW:RFAY_XANCP (EMBL:U19896) Xanthomonas campestris probable RNA polymerase sigma factor RfaY%2C 217 aa%3B fasta scores: opt: 135 z-score: 168.4 E(): 0.058%3B 30.9%25 identity in 136 aa overlap gene gene1560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1564 SCO1565 SCO1565 SCL11.21c SCL11.21c 1674848 1676026 - glycerophosphoryl diester phosphodiesterase SCL24.01c%2C probable glycerophosphoryl diester phosphodiesterase (fragment)%2C len: >291 aa%3B similar to SW:GLPQ_ECOLI (EMBL:X56907) Escherichia coli glycerophosphoryl diester phosphodiesterase%2C periplasmic precursor (EC 3.1.4.46) GlpQ%2C 358 aa%3B fasta scores: opt: 321 z-score: 336.9 E(): 2.4e-11%3B 35.1%25 identity in 228 aa overlap. Contains possible N-terminal region signal peptide sequence~SCL11.21c%2C probable glycerophophosdyl diester phosphodiesterase (fragment)%2C len: >133 aa%3B similar to SW:GLPQ_ECOLI (EMBL:X56907) Escherichia coli glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) GlpQ%2C 358 aa%3B fasta scores: opt: 146 z-score: 185.0 E(): 0.0069%3B 34.3%25 identity in 102 aa overlap gene gene1561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1565 SCO1566 SCO1566 SCL24.02 SCL24.02 1676402 1677073 + acyltransferase SCL24.02%2C possible acyltransferase%2C len: 223 aa%3B similar to TR:Q9ZBS1 (EMBL:AL034447) Streptomyces coelicolor acyltransferase SC7A1.02%2C 264 aa%3B fasta scores: opt: 277 z-score: 327.1 E(): 8.5e-11%3B 30.7%25 identity in 202 aa overlap and to TR:CAB51970 (EMBL:AL109661) Streptomyces coelicolor hypothetical 28.2 kD protein SC6E10.16c%2C 262 aa%3B fasta scores: opt: 858 z-score: 879.9 E(): 0%3B 59.0%25 identity in 217 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase%2C Acyltransferase gene gene1562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1566 SCO1567 SCO1567 SCL24.03c SCL24.03c 1677149 1678681 - transmembrane-transport protein SCL24.03c%2C possible transmembrane-transport protein%2C len: 510 aa%3B similar to TR:O33968 (EMBL:U80063) Streptomyces cinnamoneus transmembrane%2C proton-dependent transport protein%2C 519 aa%3B fasta scores: opt: 2339 z-score: 2439.5 E(): 0%3B 72.7%25 identity in 510 aa overlap and to SW:QACA_STAAU (EMBL:X56628) Staphylococcus aureus antiseptic resistance protein QacA%2C 514 aa%3B fasta scores: opt: 1116 z-score: 1166.8 E(): 0%3B 36.6%25 identity in 503 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1567 SCO1568 SCO1568 SCL24.04c SCL24.04c 1678678 1679247 - TetR family transcriptional regulator SCL24.04c%2C probable tetR-family transcriptional regulator%2C len: 189 aa%3B similar to SW:NFXB_PSEAE (EMBL:X65646) Pseudomonas aeruginosa transcriptional regulatory protein NfxB%2C 187 aa%3B fasta scores: opt: 297 z-score: 367.8 E(): 4.5e-13%3B 33.3%25 identity in 174 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Contains also possible helix-turn-helix motif at residues 28..49 (+5.21 SD) gene gene1564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1568 SCO1569 SCO1569 SCL24.05c SCL24.05c 1679335 1680387 - oxidoreductase SCL24.05c%2C possible oxidoreductase%2C len: 350 aa%3B similar to TR:AAF09836 (EMBL:AE001886) Deinococcus radiodurans oxidoreductase%2C DR0249%2C 357 aa%3B fasta scores: opt: 1019 z-score: 1133.1 E(): 0%3B 51.0%25 identity in 359 aa overlap gene gene1565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1569 SCO1570 SCO1570 argH argH 1680432 1681859 - argininosuccinate lyase catalyzes the formation of arginine from (N-L-arginino)succinate gene gene1566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1570 SCO1571 SCO1571 SCL24.07 SCL24.07 1681979 1682566 + hypothetical protein SCL24.07%2C unknown%2C len: 195 aa gene gene1567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1571 SCO1572 SCO1572 SCL24.08 SCL24.08 1682570 1683286 + hypothetical protein SCL24.08%2C possible hypothetical protein%2C len: 238 aa%3B similar to TR:O07236 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 22.5 kD protein MTCY63.14%2C 218 aa%3B fasta scores: opt: 315 z-score: 359.1 E(): 1.4e-12%3B 31.2%25 identity in 218 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1572 SCO1573 SCO1573 SCL24.09 SCL24.09 1683419 1684756 + oxidoreductase membrane protein SCL24.09%2C possible oxidoreductase (membrane protein)%2C len: 445 aa%3B similar to SW:XYLZ_PSEPU (EMBL:M64747) Pseudomonas putida toluate 1%2C2-dioxygenase subunit XylZ%2C 336 aa%3B fasta scores: opt: 236 z-score: 273.1 E(): 8.6e-08%3B 25.4%25 identity in 228 aa overlap. Contains Pfam match to entry PF00175 oxidored_fad%2C Oxidoreductase FAD/NAD-binding domain. Contains also possible hydrophobic membrane spanning regions gene gene1569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1573 SCO1574 SCO1574 SCL24.10 SCL24.10 1684919 1685587 + hypothetical protein SCL24.10%2C unknown%2C len: 222 aa gene gene1570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1574 SCO1575 SCO1575 SCL24.11 SCL24.11 1685643 1686383 + thiamine biosynthesis lipoprotein SCL24.11%2C possible thiamine biosynthesis lipoprotein precursor%2C len: 246 aa%3B similar to SW:APBE_TREPA (EMBL:AE001250) Treponema pallidum thiamine biosynthesis lipoprotein ApbE precursor%2C 362 aa%3B fasta scores: opt: 224 z-score: 251.2 E(): 1.4e-06%3B 34.9%25 identity in 172 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1575 SCO1576 SCO1576 argR argR 1686616 1687155 - arginine repressor regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes gene gene1572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1576 SCO1577 SCO1577 argD argD 1687163 1688371 - acetylornithine aminotransferase catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine gene gene1573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1577 SCO1578 SCO1578 argB argB 1688368 1689288 - acetylglutamate kinase catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate gene gene1574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1578 SCO1579 SCO1579 argJ argJ 1689285 1690436 - bifunctional ornithine acetyltransferase/N-acetylglutamate synthase bifunctional arginine biosynthesis protein ArgJ%3B functions at the 1st and 5th steps in arginine biosynthesis%3B involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate gene gene1575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1579 SCO1580 SCO1580 argC argC 1690433 1691461 - N-acetyl-gamma-glutamyl-phosphate reductase catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis%3B involved in both the arginine and lysine biosynthetic pathways%3B lysine is produced via the AAA pathway%2C lysine from alpha-aminoadipate gene gene1576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1580 SCO1581 SCO1581 SCI35.03 SCI35.03 1691495 1692058 + hypothetical protein SCI35.03%2C membrane protein%2C len: 187 aa. Contains possible hydrophobic membrane spanning regions gene gene1577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1581 SCO1582 SCO1582 SCI35.04c SCI35.04c 1692048 1692572 - ATP/GTP binding protein SCI35.04c%2C ATP/GTP binding protein%2C len: 174 aa%3B similar to TMRB_BACSU tunicamycin resistance protein (197 aa)%2C fasta scores%3B opt: 282 z-score: 488.2 E(): 6.1e-20%2C 39.5%25 identity in 119 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1582 SCO1583 SCO1583 SCI35.05c SCI35.05c 1692635 1695109 - arabinosidase SCI35.05c%2C probable arabinosidase%2C len: 824 aa%3B similar to e.g. TR:Q59218 (EMBL:U15178) arabinosidase (EC 3.2.1.55) (Bacteroides ovatus) (660 aa)%2C fasta scores%3B opt: 1204 z-score: 1030.7 E(): 0%2C 41.4%25 identity in 601 aa overlap gene gene1579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1583 SCO1584 SCO1584 SCI35.06 SCI35.06 1695246 1695704 + hypothetical protein SCI35.06%2C unknown%2C len: 152 aa gene gene1580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1584 SCO1585 SCO1585 SCI35.07c SCI35.07c 1695667 1696287 - hypothetical protein SCI35.07c%2C hypothetical protein%2C len: 206 aa%3B similar to TR:O87860 (EMBL:Z15137) Streptomyces chrysomallus hypothetical protein%2C 144 aa%3B fasta scores: opt: 536 Z-score: 638.4 E(): 6.3e-28%3B 66.929%25 identity in 127 aa overlap gene gene1581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1585 SCO1586 SCO1586 SCI35.08c SCI35.08c 1696361 1696801 - hypothetical protein SCI35.08c%2C hypothetical protein%2C len: 146 aa%3B distant similarity to a hypothetical protein from Synechocystis sp. TR:Q55911 (EMBL:D64005) SLL0286 (171 aa)%2C fasta scores%3B opt: 142 z-score: 208.1 E(): 0.00024%2C 33.9%25 identity in 127 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family%2C score 24.80%2C E-value 0.002 gene gene1582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1586 SCO1587 SCO1587 SCI35.09c SCI35.09c 1696856 1698298 - transcriptional regulator SCI35.09c%2C possible transcriptional regulator%2C len: 480 aa%3B similar to hypothetical proteins e.g. TR:P96681 (EMBL:AB001488) YdfD (B. subtilis) (482 aa)%2C fasta scores%3B opt: 535 z-score: 419.1 E(): 4.2e-16%2C 26.1%25 identity in 471 aa overlap and YRDX_RHOSH hypothetical transcriptional regulator (456 aa)%2C fasta scores%3B opt: 299 z-score: 407.0 E(): 2e-15%2C 27.2%25 identity in 464 aa overlap. Contains probable helix-turn-helix motif at aa 17-38 (Score 1327%2C +3.71 SD) and Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family%2C score 41.30%2C E-value 3.4e-11 gene gene1583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1587 SCO1588 SCO1588 SCI35.10 SCI35.10 1698333 1699295 + hypothetical protein SCI35.10%2C probable integral membrane protein%2C len: 320 aa%3B highly similar to a hypothetical protein from B. subtilis TR:P96668 (EMBL:AB001488) YdeK protein%2C 287 aa%3B fasta scores%3B opt: 624 z-score: 893.6 E(): 0%2C 40.3%25 identity in 293 aa overlap gene gene1584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1588 SCO1589 SCO1589 SCI35.11 SCI35.11 1699336 1699530 + hypothetical protein SCI35.11%2C hypothetical protein%2C len: 64 aa%3B similar to two small hypothetical proteins from M. tuberculosis e.g. YU07_MYCTU MTCY339.07C (80 aa)%2C fasta scores%3B opt: 169 z-score: 320.8 E(): 1.3e-10%2C 46.6%25 identity in 58 aa overlap gene gene1585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1589 SCO1590 SCO1590 SCI35.12c SCI35.12c 1699562 1700806 - hypothetical protein SCI35.12c%2C hypothetical protein%2C len: 414 aa%3B similar to hypothetical proteins from several organisms e.g. E. coli TR:P76130 (EMBL:AE000246) (439 aa)%2C fasta scores%3B opt: 879 z-score: 1103.6 E(): 0%2C 39.6%25 identity in 407 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1590 SCO1591 SCO1591 SCI35.13 SCI35.13 1700944 1701855 + 3-hydroxybutyryl-CoA dehydrogenase converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA gene gene1587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1591 SCO1592 SCO1592 SCI35.14c SCI35.14c 1701846 1702388 - hypothetical protein SCI35.14c%2C hypothetical protein%2C len: 180 aa%3B similar to other hypothetical proteins containing a mutT domain e.g. YQKG_BACSU (185 aa)%2C fasta scores%3B opt: 192 z-score: 280.5 E(): 2.2e-08%2C 29.2%25 identity in 168 aa overlap. Contains PS00893 mutT domain signature%2C Pfam match to entry PF00293 mutT%2C Bacterial mutT protein%2C score 28.70%2C E-value 1e-06%2C and TTA Leu codon: possible target for action of bldA gene gene1588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1592 SCO1593 SCO1593 SCI35.15c SCI35.15c 1702516 1703856 - transcriptional regulator SCI35.15c%2C possible transcriptional regulator%2C len: 446 aa%3B similar to transcriptional regulators in S. griseus and S. colelicolor: SP15_STRGR 55.5 kD and 49.5 sporulation proteins (529 aa)%2C fasta scores%3B opt: 399 z-score: 694.6 E(): 1.9e-31%2C 31.5%25 identity in 505 aa overlap and TR:Q53958 (EMBL:M80614) sporulation-associated protein genes (473 aa)%2C fasta scores%3B opt: 405 z-score: 692.7 E(): 2.5e-31%2C 35.2%25 identity in 449 aa overlap. Contains PS00041 Bacterial regulatory proteins%2C araC family signature gene gene1589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1593 SCO1594 SCO1594 pheT pheT 1704284 1706806 - phenylalanyl-tRNA synthetase subunit beta catalyzes a two-step reaction%2C first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B forms a tetramer of alpha(2)beta(2)%3B binds two magnesium ions per tetramer%3B type 2 subfamily gene gene1590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1594 SCO1595 SCO1595 pheS pheS 1706806 1707882 - phenylalanyl-tRNA synthetase subunit alpha catalyzes a two-step reaction%2C first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B forms a heterotetramer of alpha(2)beta(2)%3B binds two magnesium ions per tetramer%3B type 1 subfamily gene gene1591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1595 SCO1596 SCO1596 SCI35.18c SCI35.18c 1708109 1709248 - two-component sensor SCI35.18c%2C probable two-component sensor%2C len: 379 aa%3B similar to many e.g. HYDH_ECOLI sensor protein hydH (465 aa)%2C fasta scores%3B opt: 296 z-score: 418.4 E(): 4.6e-16%2C 35.4%25 identity in 257 aa overlap. No apparent transmembrane domains. Contains Pfam match to entry PF00512 signal%2C Signal carboxyl-terminal domain%2C score 205.10%2C E-value 1e-57 gene gene1592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1596 SCO1597 SCO1597 SCI35.19c SCI35.19c 1709299 1710147 - rRNA methylase SCI35.19c%2C probable rRNA methylase%2C len: 282 aa%3B similar to many members of ther spoU famil e.g. TSNR_STRLU 23s rRNA methyltransferase (270 aa)%2C fasta scores%3B opt: 254 z-score: 251.7 E(): 9e-07%2C 27.0%25 identity in 270 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase%2C SpoU rRNA Methylase family%2C score 107.90%2C E-value 1.9e-28 gene gene1593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1597 SCO1598 SCO1598 rplT rplT 1710331 1710714 - 50S ribosomal protein L20 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit gene gene1594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1598 SCO1599 SCO1599 rpmI rpmI 1710812 1711006 - 50S ribosomal protein L35 SCI35.21c%2C rpmI%2C 50S ribosomal protein L35%2C len: 64 aa%3B similar to many e.g. RL35_BACSU 50S ribosomal protein L35 (65 aa)%2C fasta scores%3B opt: 179 z-score: 355.6 E(): 1.5e-12%2C 45.9%25 identity in 61 aa overlap gene gene1595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1599 SCO1600 SCO1600 infC infC 1711121 1711774 - translation initiation factor IF-3 IF-3 has several functions that are required and promote translation initiation including%3B preventing association of 70S by binding to 30S%3B monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites%3B stimulates codon-anticodon interactions at P-site%3B involved in moving mRNA to the P-site%3B and in recycling subunits gene gene1596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1600 SCO1601 SCO1601 SCI35.23 SCI35.23 1712158 1712523 + hypothetical protein SCI35.23%2C unknown%2C len: 121 aa gene gene1597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1601 SCO1602 SCO1602 SCI35.24c SCI35.24c 1712548 1713279 - hypothetical protein SCI35.24c%2C unknown%2C len: 243 aa%3B possible truncated at N-terminus by IS117 gene gene1598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1602 SCO1603 SCO1603 SCI35.25 SCI35.25 1713855 1715099 + transposase SCI35.25%2C probable transposase for IS117%2C len: 414 aa%3B identical to YYM3_STRCO mini-circle hypothetical 45.7 kd protein (414 aa) and similar to many others e.g. YI11_STRCL insertion element IS116 hypothetical 44.8 kD protein (399 aa)%2C fasta scores%3B opt: 324 z-score: 416.9 E(): 5.6e-16%2C 27.4%25 identity in 413 aa overlap gene gene1599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1603 SCO1604 SCO1604 SCI35.26c SCI35.26c 1715151 1715678 - hypothetical protein SCI35.26c%2C unknown ORF in IS117%2C len: 175 aa%3B identical to%2C but longer than%2C YM2_STRCO mini-circle hypothetical 13.3 KD protein (122 aa). Note alternative ORF on opposite strand. Contains TTA Leu codon%3B possible target for action of bldA gene gene1600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1604 SCO1605 SCO1605 SCI35.27 SCI35.27 1715196 1715549 + hypothetical protein SCI35.27%2C unknown ORF in IS117%2C len: 117 aa%3B identical to YM1_STRCO mini-circle hypothetical 12.9 KD protein (117 aa). Note alternative ORF on opposite strand gene gene1601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1605 SCO1606 SCO1606 SCI35.28 SCI35.28 1715926 1716894 + hypothetical protein SCI35.28%2C possible membrane protein%2C len: 322 aa%3B similar to S. coelicolor TR:O69914 (EMBL:AL023861) hypothetical protein SC3C8.01 (302 aa)%2C fasta scores%3B opt: 730 z-score: 709.0 E(): 3e-32%2C 48.0%25 identity in 275 aa overlap. Contains possible hydrophobic membrane spanning region gene gene1602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1606 SCO1607 SCO1607 SCI35.29c SCI35.29c 1716909 1718090 - serine protease membrane protein SCI35.29c%2C probable serine protease (membrane protein)%2C len: 393 aa%3B similar to many members of the subtilase family e.g. SUBT_BACLI subtilisin carlsberg precursor (379 aa)%2C fasta scores%3B opt: 377 z-score: 509.5 E(): 3.9e-21%2C 38.8%25 identity in 276 aa overlap. Contains probable possible hydrophobic membrane spanning regions (one possible hydrophobic span at the N-terminal region and another one at the C-terminal region)%2C PS00136 Serine proteases%2C subtilase family%2C aspartic acid active sitea and Pfam match to entry PF00082 subtilase%2C Subtilase family of serine proteases%2C score 177.60%2C E-value 2.1e-49 gene gene1603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1607 SCO1608 SCO1608 SCI35.30c SCI35.30c 1718087 1718800 - hypothetical protein SCI35.30c%2C unknown%2C len: 237 aa%3B start uncertain%2C may be considerably further upstream gene gene1604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1608 SCO1609 SCO1609 SCI35.31 SCI35.31 1720261 1721469 + hypothetical protein SCI35.31%2C unknown%2C len: 402 aa%3B similar to a hypothetical protein from M. tuberculosis TR:O06802 (EMBL:Z95890) MTCY28.35 (414 aa)%2C fasta scores%3B opt: 1341 z-score: 1649.4 E(): 0%2C 53.8%25 identity in 398 aa overlap gene gene1605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1609 SCO1610 SCO1610 SCI35.32c SCI35.32c 1721502 1722461 - hypothetical protein SCI35.32c%2C possible membrane protein%2C len: 319 aa%3B similar to TR:Q9XAN5 (EMBL:AL079355) Streptomyces coelicolor membrane protein SC4C6.05c%2C 347 aa%3B fasta scores: opt: 474 Z-score: 431.9 E(): 2e-16%3B 37.853%25 identity in 354 aa overlap. Contains possible transmembrane domain at around aa 80 gene gene1606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1610 SCO1611 SCO1611 SCI35.33c SCI35.33c 1722499 1723281 - 3-oxoacyl-ACP reductase SCI35.33c%2C probable dehydrogenase%2C len: 260 aa%3B similar to members of the short-chain dehydrogenases/reductases family e.g. LINX_PSEPA 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-diol dehydrogenase (250 aa)%2C fasta scores%3B opt: 532 z-score: 629.1 E(): 8.5e-28%2C 36.0%25 identity in 250 aa overlap. Contains Pfam matches to entry PF00106 adh_short%2C Alcohol /other%2C score 230.30%2C E-value 2.7e-65%2C and to entry PF00678 adh_short_C2%2C Short chain dehydrogenase /reductase C-terminus%2C score 41.20%2C E-value 2.4e-08 gene gene1607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1611 SCO1612 SCO1612 SCI35.34c SCI35.34c 1723278 1724729 - aldehyde dehydrogenase SCI35.34c%2C probable aldehyde dehydrogenase%2C len: 483 aa%3B similar to many e.g. DHAB_RHIME betaine aldehyde dehydrogenase (487 aa)%2C fasta scores%3B opt: 1113 z-score: 1170.6 E(): 0%2C 42.4%25 identity in 462 aa overlap. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site%2C PS00070 Aldehyde dehydrogenases cysteine active site and Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenases%2C score 569.80%2C E-value 1.7e-167 gene gene1608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1612 SCO1613 SCO1613 SCI35.35c SCI35.35c 1724726 1726114 - glutamine synthetase SCI35.35c%2C possible glutamine synthetase%2C len: 462 aa%3B similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa)%2C fasta scores%3B opt: 536 z-score: 653.9 E(): 3.6e-29%2C 31.6%25 identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt%2C Glutamine synthetase%2C score 123.40%2C E-value 9.4e-39 gene gene1609 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1613 SCO1614 SCO1614 SCI35.36 SCI35.36 1726192 1726902 + transcriptional regulator SCI35.36%2C probable transcriptional regulator%2C len: 236 aa%3B similar to many members of the gntR family e.g. GLCC_ECOLI Glc operon transcriptional activator (254 aa)%2C fasta scores%3B opt: 183 z-score: 269.1 E(): 9.7e-08%2C 28.3%25 identity in 219 aa overlap. Contains PS00043 Bacterial regulatory proteins%2C gntR family signature%2C probable helix-turn-helix motif at aa 42-63 (Score 1486%2C +4.25 SD)%2C and Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family%2C score 64.70%2C E-value 2e-18 gene gene1610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1614 SCO1615 SCO1615 SCI35.37 SCI35.37 1726978 1727706 + hypothetical protein SCI35.37%2C unknown%2C len: 726 aa%3B similar to hypotheticals e.g. YCJL_ECOLI (258 aa)%2C fasta scores%3B opt: 216 z-score: 265.7 E(): 1.5e-07%2C 31.8%25 identity in 201 aa overlap gene gene1611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1615 SCO1616 SCO1616 SCI35.38c SCI35.38c 1728427 1729404 - transcriptional regulator SCI35.38c%2C probable transcriptional regulator%2C len: 325 aa%3B similar to many members of the lysR family CBBR_RHORU RUBISCO operon transcriptional regulator (298 aa)%2C fasta scores%3B opt: 394 z-score: 410.2 E(): 1.3e-15%2C 30.2%25 identity in 295 aa overlap. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature%2C possible helix-turn-helix motif at aa 53-74 (Score 1391%2C +3.92 SD)%2C and Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix proteins%2C lysR family%2C score 129.30%2C E-value 7e-35 gene gene1612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1616 SCO1617 SCO1617 SCI35.39 SCI35.39 1729475 1730659 + hypothetical protein SCI35.39%2C probable integral membrane protein%2C len: 394 aa%3B similar to several hypothetical membrane proteins e.g. Rhodococcus erythropolis TR:O07448 (EMBL:AF002247) (295 aa)%2C fasta scores%3B opt: 868 z-score: 961.0 E(): 0%2C 44.9%25 identity in 292 aa overlap gene gene1613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1617 SCO1618 SCO1618 SCI35.40c SCI35.40c 1730586 1731305 - hypothetical protein SCI41.01c%2C hypothetical protein%2C len: >212 aa. Low similarity with C-terminus of TR:BAA80034 (EMBL:AP000060) Aeropyrum pernix 493 aa hypothetical protein APE1049 (493 aa)%3B fasta scores: opt: 183 z-score: 217.5 E(): 9.6e-05%3B 29.2%25 identity in 202 aa overlap. Overlaps and extends StI35.40c~SCI35.40c%2C unknown. partial CDS%2C len: >68 aa gene gene1614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1618 SCO1619 SCO1619 SCI41.02c SCI41.02c 1731316 1731885 - regulatory protein SCI41.02c%2C possible transcriptional regulatory protein%2C len: 189 aa%3B similarity with TR:O53759 (EMBL:AL021933) Mycobacterium tuberculosis regulatory protein (140 aa)%3B fasta scores: opt: 164 z-score: 208.0 E(): 0.00032%2C 31.3%25 identity in 112 aa overlap. Contains Pfam match PF01381 HTH_3%2C Helix-turn-helix. Contains probable helix-turn-helix motif at aa 25-46 (Score 1293%2C +3.59 SD) gene gene1615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1619 SCO1620 SCO1620 opuABC opuABC 1732259 1734874 - glycine/betaine ABC transporter permease SCI41.03c%2C opuABC glycine/betaine transport system permease%2C len: 871 aa. N-terminal region highly similar to SW:OPUB_BACSU (P46921) Bacillus subtilis glycine/betaine transport system permease %3B fasta scores: opt: 847 z-score: 884.1 E(): 0%3B 47.2%25 identity in 269 aa overlap%2C and C-terminal region similar to SW:OPUC_BACSU glyine betaine-binding protein precusor%3B fasta scores%3B opt: 322 z-score: 339.7 E(): 1.5e-11%3B 32.8%25 identity in 271 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C binding-protein-dependent transport systems inner membrane component and prosite match to entry PS00402 Binding-protein-dependent transport systems inner membrane component sign gene gene1616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1620 SCO1621 SCO1621 opuAA opuAA 1734867 1735961 - glycine/betaine transport ATP-binding protein SCI41.04c%2C opuAA glycine/betaine transport ATP-binding protein%2C len: 364 aa. Highly similar to SW:OPUA_BACSU (P46920) Bacillus subtilis glycine/betaine transport ATP-binding protein%3B fasta scores: opt: 1093 z-score: 1200.6 E():0%3B 52.4%25 identity in 328 aa overlap. Contains Pfam match to PF00005 ABC_tran%2C ABC transporter and PS00211 ABC transporters family signature. gene gene1617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1621 SCO1622 SCO1622 SCI41.05 SCI41.05 1736156 1737061 + 5'-3' exonuclease SCI41.05%2C probable 5'-3' exonuclease%2C len: 301 aa. High similarity to SW:EX53_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis potential 5'-3' exonuclease (EC 3.1.11.-)%2C 393 aa%3B fasta scores: opt: 964 z-score: 1025.6 E(): 0%3B 52.3%25 identity in 308 aa overlap. Contains Pfam match to entry PF01367 5_3_exonuclease%2C 5'-3' exonuclease. gene gene1618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1622 SCO1623 SCO1623 SCI41.06 SCI41.06 1737167 1738009 + hypothetical protein SCI41.06%2C unknown%2C len: 280 aa%3B similar to e.g. YX26_MYCTU hypothetical 30.6 KD protein CY274.26C%2C 283 aa%3B fasta scores: opt: 641 z-score: 744.6 E()0%3B 45.9%25 identity in 294 aa overlap gene gene1619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1623 SCO1624 SCO1624 SCI41.07c SCI41.07c 1738408 1738998 - acetyltransferase SCI41.07c%2C probable acetyltransferase%2C len: 165 aa. Similar to various acetyltransferases%2C e.g. SW:RIML_ECOLI (EMBL:X15860) Escherichia coli ribosomal-protein-serine acetyltransferase%2C 179 aa%3B fasta scores: opt: 181 z-score: 247.2 E(): 2.1e-06%3B 28.0%25 identity in 132 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene1620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1624 SCO1625 SCO1625 SCI41.08 SCI41.08 1739097 1740071 + ribosomal pseudouridine synthase SCI41.08%2C probable ribosomal pseudouridine synthase%2C len: 324 aa. Similar to SW:RLUA_ECOLI (EMBL:D10483) Escherichia coli ribosomal large subunit pseudouridine synthase 218 aa%3B fasta scores: opt: 262 z-score: 302.0 E(): 1.9e-09%3B 31.7%25 identity in 221 aa overlap. Contains Pfam match to entry PF00849 YABO%2C Hypothetical yabO/yceC/sfhB family also PS01129 Rlu family of pseudouridine synthase signature gene gene1621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1625 SCO1626 SCO1626 SCI41.09c SCI41.09c 1740065 1741561 - cytochrome P450 SCI41.09c%2C possible cytochrome P450%2C len: 498 aa. Similar to cytochrome P450 family%2C e.g. SW:CPXF_STRGO (EMBL:M32239) Streptomyces griseolus cytochrome P450-SU2 (EC 1.14.-.-) (P450-CVB%2C 402 aa)%3B fasta scores: opt: 492 z-score: 485.2 E(): 1.2e-19%3B 31.0%25 identity in 407 aa overlap. Contains Pfam match to entry PF00067 p450%2C cytochrome P450. gene gene1622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1626 SCO1627 SCO1627 cvnD9 cvnD9 1741637 1742167 - ATP-GTP binding protein SCI41.10c%2C cvnD9%2C probable ATP-GTP binding protein%2C len: 176 aa. Highly similar to TR:CAB41559 (EMBL:AL049727) Streptomyces coelicolor SC9B1.13C ATP/GTP-binding protein%2C 181 aa%3B fasta scores: opt: 684 z-score: 845.9 E():0%3B 63.0%25 identity in 173 aa overlap. Contains Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1627 SCO1628 SCO1628 cvnC9 cvnC9 1742238 1742654 - hypothetical protein SCI41.11c%2C cvnC9%2C hypothetical protein%2C len: 138 aa. Similar to TR:CAB41560 (EMBL:AL049727) Streptomyces coelicolor SC9B1.14C hypothetical 12.8 kd protein%2C 119 aa%3B fasta scores: opt: 240 z-score: 262.1 E(): 3.1e-07%3B 45.0%25 identity in 109 aa overlap and to TR:Q9AJP2 (EMBL:AB044803) Streptomyces griseus ORF3%2C 123 aa%3B fasta scores: opt: 472 Z-score: 497.8 E(): 4.3e-20%3B 58.273%25 identity in 139 aa overlap gene gene1624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1628 SCO1629 SCO1629 cvnB9 cvnB9 1742651 1743058 - hypothetical protein SCI41.12c%2C cvnB9%2C unknown%2C len: 135 aa. Similar to TR:CAB41561 (EMBL:AL049727) Streptomyces coelicolor SC9B1.15C hypothetical 14.3 kD protein%2C 137 aa%3B fasta scores: opt: 266 z-score: 339.1 E(): 1.6e-11%3B 37.0%25 identity in 127 aa overlap and to TR:Q9AJP3 (EMBL:AB044803) Streptomyces girseus ORF2%2C 135 aa%3B fasta scores: opt: 559 Z-score: 671.5 E(): 9e-30%3B 62.687%25 identity in 134 aa overlap gene gene1625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1629 SCO1630 SCO1630 cvnA9 cvnA9 1743055 1744680 - hypothetical protein SCI41.13c%2C cvnA9%2C possible integral membrane protein%2C len: 541 aa. N-terminal domain similar to TR:CAB45635 (EMBL:AL079356) Streptomyces coelicolor SC6G9.44C possible histidine sensor kinase (806 aa)%3B fasta scores: opt: 423 z-score: 422.2 E(): 3.8e-16%3B 26.4%25 identity in 481 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1630 SCO1631 SCO1631 SCI41.14c SCI41.14c 1745083 1747935 - helicase SCI41.14c%2C possible helicase%2C len: 950 aa. Similar to TR:O69801 (EMBL:AJ223310) Streptomyces avermitilis SAB3 helicase%2C 612 aa%3B fasta scores: opt: 2382 z-score: 2658.3 E(): 0%3B 68.9%25 identity in 602 aa overlap. Contains Pfam match to entry PF00270 DEAD%2C DEAD/DEAH box helicase and PS00017 ATP/GTP-binding site motif A (P-loop). Contains probable coiled-coil from 554 to 586 (33 residues%2C max score: 1.477%2C probability 0.92). gene gene1627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1631 SCO1632 SCO1632 SCI41.15c SCI41.15c 1748003 1748953 - hypothetical protein SCI41.15c%2C hypothetical integral membrane protein%2C len: 316 aa. Similarity to SW:Q10702 SW:YK93_MYCTU Mycobacterium tuberculosis unknown membrane protein RV2093c%2C 308 aa%3B fasta scores: opt: 638 z-score: 762.5 E():0%3B 40.1%25 identity in 289 aa overlap. Contains Pfam match to entry PF00902 UPF0032%2C MttB family. gene gene1628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1632 SCO1633 SCO1633 tatA tatA 1749001 1749288 - twin arginine translocase A TatA%3B similar to TatE that is found in some proteobacteria%3B part of system that translocates proteins with a conserved twin arginine motif across the inner membrane%3B capable of translocating folded substrates typically those with bound cofactors%3B similar to a protein import system in thylakoid membranes gene gene1629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1633 SCO1634 SCO1634 SCI41.17c SCI41.17c 1749565 1749759 - small membrane protein SCI41.17c%2C small membrane protein%2C len: 64 aa. Contains probable coiled-coil from 28 to 64 (37 residues%2C max score: 1.439%2C probability 0.85) and possible hydrophobic membrane spanning region gene gene1630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1634 SCO1635 SCO1635 SCI41.18c SCI41.18c 1749770 1750081 - hypothetical protein SCI41.18c%2C unknown%2C len: 103 aa gene gene1631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1635 SCO1636 SCO1636 SCI41.19c SCI41.19c 1750078 1751160 - hypothetical protein SCI41.19c%2C unknown%2C len: 360 aa. Similar to various hypothetical proteins%2C e.g. TR:P72265 (EMBL:Z82004) Rhodococcus erythropolis ORF11%2C 326 aa%3B fasta scores: opt: 694 z-score: 768.9 E(): 0%3B 39.8%25 identity in 322 aa overlap gene gene1632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1636 SCO1637 SCO1637 SCI41.20c SCI41.20c 1751179 1752132 - hypothetical protein SCI41.20c%2C unknown%2C len: 317 aa. Similar to various hypothetical proteins%2C e.g. TR:P72264 (EMBL:Z82004) Rhodococcus erythropolis ORF10%2C 330 aa%3B fasta scores: opt: 578 z-score: 682.7 E(): 1.2e-30%3B 39.5%25 identity in 332 aa overlap gene gene1633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1637 SCO1638 SCO1638 fkbP fkbP 1752270 1752641 - peptidyl-prolyl cis-trans isomerase SCI41.21c%2C fkbP%2C peptidyl-prolyl cis-trans isomerase%2C len: 123 aa. Highly similar to SW:FKBP_STRCH (EMBL:M98428) Streptomyces chrysomallus FK506-binding protein (peptidyl-prolyl cis-trans isomerase - PPIase%2C 124 aa)%3B fasta scores: opt: 678 z-score: 808.5 E(): 0%3B 78.2%25 identity in 124 aa overlap. Contains Pfam match to entry PF00254 FKBP%2C FKBP-type peptidyl-prolyl cis-trans isomerases also PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1 and PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. Similarities with C-terminal domain of Streptomyces coelicolor StI41.22c (335 aa)%3B fasta scores: opt: 263 z-score: 285.2 E(): 1.4e-10%3B 40.2%25 identity in 117 aa overlap. C-terminal contains signal peptide gene gene1634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1638 SCO1639 SCO1639 SCI41.22c SCI41.22c 1752701 1753708 - peptidyl-prolyl cis-trans isomerase SCI41.22c%2C probable peptidyl-prolyl cis-trans isomerase%2C len: 335 aa. Similar to TR:Q53919 (EMBL:Z34523) Streptomyces chrysomallus FkbB%2C 312 aa%3B fasta scores: opt: 984 z-score: 1016.1 E():0%3B 49.1%25 identity in 336 aa overlap. Contains two Pfam matches to entry PF00254 FKBP%2C FKBP-type peptidyl-prolyl cis-trans isomerases and two Prosite matches to entry PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2 and also PS00013 prokaryotic membrane lipoprotein lipid attachment site in the correct position. C-terminal contains similarities with Streptomyces coelicolor StI41.21c%2C (244 aa)%3B fasta scores: opt: 134 z-score: 133.2 E():0.04%3B 31.1%25 identity in 177 aa overlap gene gene1635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1639 SCO1640 SCO1640 SCI41.23c SCI41.23c 1753890 1755251 - hypothetical protein SCI41.23c%2C unknown%2C len: 453 aa. Highly similar to Mycobacterium tuberculosis SW:YY37_MYCTU (EMBL:Z73966) hypothetical 51.4 kd protein CY49.37c%2C 452 aa%3B fasta scores: opt: 2309 z-score: 2768.8 E():0%3B 73.5%25 identity in 453 aa overlap. Contains also similarities with Streptomyces coelicolor StI41.30c%2C (497 aa)%3B fasta scores: opt: 962 z-score: 1024.1 E():0%3B 41.9%25 identity in 413 aa overlap. gene gene1636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1640 SCO1641 SCO1641 SCI41.24c SCI41.24c 1755261 1756478 - transporter SCI41.24c%2C probable transport protein%2C len: 405 aa%3B identical to TR:O87601 (EMBL:AF086832) S. coelicolor transporter (419 aa)%2C and similar to e.g. TR:O30996 (EMBL:AF024666) Corynebacterium striatum R-plasmid pTP10 chloramphenicol export protein (391 aa)%2C fasta scores%3B opt: 194 z-score: 210.6 E(): 0.00023%2C 25.9%25 identity in 394 aa overlap gene gene1637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1641 SCO1642 SCO1642 SCI41.25 SCI41.25 1756582 1757634 + LacI family regulator SCI41.25%2C LacI family regulator%2C len 336 aa. Identical to TR:O87600 (EMBL:AF086832) Streptomyces coelicolor ORF4 and similar to TR:AAD36030 (EMBL:AE001758) Thermotoga maritima TM0949 transcriptional regulator%2C LacI family%2C 332 aa%3B fasta scores: opt: 476 z-score: 517.4 E(): 1.9e-21%3B 29.5%25 identity in 339 aa overlap. Contains possible helix-turn-helix motif at aa 23-44.(Score 1430%2C +4.06 SD) gene gene1638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1642 SCO1643 SCO1643 pcrA pcrA 1757649 1758413 - 20S proteasome alpha-subunit SCI41.26%2C pcrA 20S proteasome alpha-subunit%2C len: 254 aa. Identical to TR:O87599 (EMBL:AF086832) Streptomyces coelicolor 20S proteasome alpha-subunit%2C 254 aa and similar to TR:Q53080 (EMBL:U26421) Rhodococcus sp. proteasome alpha-type subunit 1%2C 259 aa%3B fasta scores: opt: 831 z-score: 982.8 E():0%3B 53.4%25 identity in 253 aa overlap. gene gene1639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1643 SCO1644 SCO1644 prcB prcB 1758475 1759320 - 20S proteasome subunit beta SCI41.27%2C pcrB 20S proteasome beta-subunit precursor%2C len: 281 aa. Identical to TR:O87598 (EMBL%3B AF086832) Streptomyces coelicolor 20S proteasome beta-subunit precursor 281 aa and similar to TR:Q53083 (EMBL%3B U26422) Rhodococcus sp. proteasome beta-type subunit 2%2C 292 aa%3B fasta socres: opt: 952 z-score: 1081.0 E():0%3B 56.7%25 identity in 277 aa overlap. gene gene1640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1644 SCO1645 SCO1645 SCI41.28c SCI41.28c 1759272 1759865 - hypothetical protein SCI41.28c%2C hypothetical protein%2C len: 197 aa. Identical to TR:O87597 (EMBL:AF086832) Streptomyces coelicolor hypothetical 18.6 kD protein and similar to SW:VG59_BPMD2 (EMBL:AF022214) Mycobacteriophage D29 gene 59 protein%2C 153 aa%3B fasta scores: opt: 175 z-score: 225.0 E(): 3.7e-05%3B 35.2%25 identity in 122 aa overlap gene gene1641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1645 SCO1646 SCO1646 SCI41.29c SCI41.29c 1759899 1760117 - hypothetical protein SCI41.29c%2C hypothetical protein%2C len: 72 aa. Identical to TR:O87596 (EMBL:AF086832) Streptomyces coelicolor hypothetical 8.0 Kd protein%2C len: 72 aa and similar to TR:Q53082 (EMBL:U26422) Rhodococcus sp. similar to Rhodococcus sp. NI86/21%2C 64 aa%3B fasta scores: opt: 197 z-score: 237.9 E(): 7e-06%3B 51.4%25 identity in 70 aa overlap. Contains probable coiled-coil from 10 to 61 (52 residues%2C max score: 1.620%2C probability 1.00) gene gene1642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1646 SCO1647 SCO1647 SCI41.30c SCI41.30c 1760296 1761789 - hypothetical protein SCI41.30c%2C hypothetical protein%2C len: 497 aa. Identical to TR:O87595 (EMBL:AF086832) Streptomyces coelicolor hypothetical 65.1 Kd protein%2C len: 497 aa and similar to TR:Q53081 (EMBL:U26422) Rhodococcus sp. similar to ORF6(1) of Rhodococcus sp. NI86/21%2C 499 aa%3B fasta scores: opt: 2019 z-score: 2370.6 E():0%3B 62.5%25 identity in 493 aa overlap. Contains also similarities with Streptomyces coelicolor StI41.23c%2C 453 aa%3B fasta scores: opt: 962 z-score: 1019.2 E():0%3B 41.9%25 identity in 413 aa overlap gene gene1643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1647 SCO1648 SCO1648 arc arc 1762040 1763806 - ATPase AAA SCI41.31c%2C arc AAA ATPase%2C len: 588 aa. Identical to TR:O87594 (EMBL:AF086832) Streptomyces coelicolor ARC%2C AAA ATPase forming ring-shaped complexes and similar to TR:O50202 (EMBL:AF088800) Rhodococcus erythropolis ARC protein%2C 591 aa%3B fasta scores: opt: 2036 z-score: 2155.8 E():0%3B 67.1%25 identity in 587 aa overlap. Pfam match to entry PF00004 AAA%2C ATPases associated with various cellular activities (AAA). Contains probable coiled-coil from 47 to 93 (47 residues%2C max score: 1.592%2C probability 0.99) gene gene1644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1648 SCO1649 SCO1649 SCI41.32 SCI41.32 1764052 1764357 + ferredoxin SCI41.32%2C ferredoxin%2C len: 101 aa. Identical to TR:087593 (EMBL:AF086832) Streptomyces coelicolor ferredoxin%2C len: 101 aa and similar to SW:FER_BACST (SW:P00212) Bacillus stearothermophilus ferredoxin%2C fasta scores: opt: 153 z-score: 211.3 E(): 0.00021%3B 33.3%25 identity in 69 aa overlap gene gene1645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1649 SCO1650 SCO1650 SCI41.33c SCI41.33c 1764432 1765022 - hypothetical protein SCI41.33c%2C hypothetical protein%2C len: 196 aa. Identical to TR:087592 (EMBL:AF086832) Streptomyces coelicolor hypothetical 20.2 Kd protein%2C len: 196 aa and low similarities to TR:CAA21729 (EMBL%3B AL032656) Caenorhabditis elegans Y106G6E.2 protein%2C 238 aa%3B fasta scores: opt: 120 z-score: 136.2 E():3.2%3B 29.3%25 identity in 116 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1650 SCO1651 SCO1651 SCI41.34c SCI41.34c 1765257 1766159 - hypothetical protein SCI41.34c%2C hypothetical protein%2C len: 300 aa. N-terminal identical to previously sequenced TR:O87591 (EMBL:AF086832) Streptomyces coelicolor hypothetical 18.8 kd protein (fragment) (168 aa)%3B fasta scores: opt: 1179 z-score: 1395.1 E(): 0%3B 100.0%25 identity in 168 aa overlap and similar to various hypothetical proteins%2C e.g. TR:Q9ZG14 (EMBL:AF088800) Rhodococcus erythropolis hypothetical 35.2 Kd protein%2C 324 aa%3B fasta scores: opt: 1134 z-score: 1338.1 E():0%3B 59.9%25 identity in 279 aa overlap gene gene1647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1651 SCO1652 SCO1652 SCI41.35c SCI41.35c 1766287 1767411 - hypothetical protein SCI41.35c%2C hypothetical protein%2C len: 374 aa%3B similar to various hypothetical proteins%2C e.g. SW:Y528_SYNY3 (EMBL:D64006) Synechocystis sp. (strain PCC 6803) hypothetical 40.5 KD protein SLL0528%2C 379 aa%3B fasta scores: opt: 547 z-score: 618.5 E(): 4.5e-27%3B 32.6%25 identity in 374 aa overlap. Contains two Pfam matches to entry PF00571 CBS%2C CBS domain%2C and a prosite match to entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature gene gene1648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1652 SCO1653 SCO1653 SCI41.36 SCI41.36 1768285 1769139 + hypothetical protein SCI41.36%2C hypothetical protein%2C len: 371aa. Similar to various hypothetical proteins%2C e.g. TR:Q9ZG15 (EMBL:AF088800) Rhodococcus erythropolis hypothetical 35.5 Kd protein (323 aa)%3B fasta scores: opt: 1017 z-score: 1034.8 E(): 0%3B 51.5%25 identity in 299 aa overlap. gene gene1649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1653 SCO1654 SCO1654 SCI41.37 SCI41.37 1769156 1769827 + two-component response regulator SCI41.37%2C possible two-component response regulator%2C len: 223 aa. Highly similar to various two-component response regulator%2C e.g. TR:CAB40929 (EMBL:AL049630) Streptomyces coelicolor SCE126.07C two component response regulator%2C 224 aa%3B fasta scores: opt: 866 z-score: 1015.8 E():0%3B 63.5%25 identity in 222 aa overlap. Pfam match to entry PF00072 response_reg%2C response regulator receiver domain also PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Contains possible helix-turn-helix motif at aa 174-195. (Score 1000%2C +2.59 SD) gene gene1650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1654 SCO1655 SCO1655 SCI41.38c SCI41.38c 1769946 1771550 - lipoprotein oligopeptide binding protein SCI41.38c%2C probable lipoprotein oligopeptide binding protein%2C len: 534 aa. Similar to TR:O54107 (EMBL:AL021529) Streptomyces coelicolor SC10A5.16C periplasmic oligopeptide binding protein%2C 521 aa%3B fasta scores: opt: 1101 z-score: 1218.9 E(): 0%3B 36.0%25 identity in 528 aa overlap. Contains two Pfam matches to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5%2C N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene1651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1655 SCO1656 SCO1656 SCI46.01c SCI46.01c 1771994 1772695 - hydrolase SCI46.01c%2C possible hydrolase%2C len: 233 aa%3B similar to TR:CAC13072 (EMBL:AL445503) Streptomyces coelicolor hydrolase 2SCG38.13%2C 238 aa%3B fasta scores: opt: 323 z-score: 377.6 E(): 1.7e-13%3B 36.6%25 identity in 191 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene1652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1656 SCO1657 SCO1657 SCI46.02c SCI46.02c 1772821 1776333 - methionine synthase SCI46.02c%2C probable methionine synthase%2C len: 1170 aa%3B similar to SW:METH_ECOLI (EMBL:X16584) Escherichia coli 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 2.1.1.13) (methionine synthase%2C vitamin-B12 dependent isozyme) MetH%2C 1226 aa%3B fasta scores: opt: 1593 z-score: 1749.1 E(): 0%3B 32.4%25 identity in 1215 aa overlap. Contains Pfam match to entry PF02310 B12-binding and match to Prosite entry PS00178 Aminoacyl-transfer RNA synthetases class-I signature gene gene1653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1657 SCO1658 SCO1658 gylR gylR 1776737 1777501 + glycerol operon regulatory protein SCI46.03%2C gylR%2C glycerol operon regulatory protein%2C len: 254 aa%3B identical to previously sequenced SW:GYLR_STRCO (EMBL:X14188) Streptomyces coelicolor glycerol operon regulatory protein GylR%2C 254 aa. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator and match to Prosite entry PS01051 Bacterial regulatory proteins%2C iclR family signature gene gene1654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1658 SCO1659 SCO1659 glpF glpF 1777840 1778634 + glycerol uptake facilitator protein SCI52.01%2C glpF%2C probable glycerol uptake facilitator protein%2C len: 264 aa%3B N-terminal region identical to previously sequenced SW:GLPF_STRCO (EMBL:X14188) Streptomyces coelicolor probable glycerol uptake facilitator protein (fragment) GlpF or GylA%2C 80 aa%2C and similar to SW:GLPF_BACSU (EMBL:M99611) Bacillus subtilis glycerol uptake facilitator protein GlpF%2C 274 aa%3B fasta scores: opt: 520 Z-score: 611.2 bits: 120.8 E(): 1.8e-26%3B 51.163%25 identity in 258 aa overlap. Contains Pfam match to entry PF00230 MIP%2C Major intrinsic protein and match to Prosite entry PS00221 MIP family signature. Also contains possible hydrophobic membrane spanning regions gene gene1655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1659 SCO1660 SCO1660 glpK glpK 1778726 1780264 + glycerol kinase SCI52.02%2C glpK%2C glycerol kinase%2C len: 512 aa%3B similar to SW:GLPK_ECOLI (EMBL:X15054) Escherichia coli glycerol kinase (EC 2.7.1.30) GlpK or B3926%2C 501 aa%3B fasta scores: opt: 1756 Z-score: 2090.6 bits: 396.4 E(): 7.3e-109%3B 52.259%25 identity in 509 aa overlap and to TR:Q9RJM2 (EMBL:AL121849) Streptomyces coelicolor glycerol kinase GlpK2 or SCF6.05%2C 508 aa%3B fasta scores: opt: 1974 Z-score: 2055.1 bits: 389.8 E(): 9.3e-109%3B 58.020%25 identity in 505 aa overlap. Contains Pfam match to entry PF00370 FGGY%2C FGGY family of carbohydrate kinases and match to Prosite entry PS00445 FGGY family of carbohydrate kinases signature 2 gene gene1656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1660 SCO1661 SCO1661 SCI52.03 SCI52.03 1780273 1781889 + glycerol-3-phosphate dehydrogenase SCI52.03%2C probable glycerol-3-phosphate dehydrogenase%2C len: 538 aa%3B similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD%2C 555 aa%3B fasta scores: opt: 751 Z-score: 835.1 bits: 164.3 E(): 6.1e-39%3B 30.830%25 identity in 506 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh%2C FAD-dependent glycerol-3-phosphate dehydrogenase gene gene1657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1661 SCO1662 SCO1662 SCI52.04 SCI52.04 1782041 1783042 + hypothetical protein SCI52.04%2C conserved hypothetical protein%2C len: 333 aa%3B similar to TR:O33260 (EMBL:Z97559) Mycobacterium tuberculosis hypothetical 31.8 kDa protein MTCY261.21%2C 292 aa%3B fasta scores: opt: 1072 Z-score: 902.2 bits: 175.1 E(): 1.1e-42%3B 57.554%25 identity in 278 aa overlap. Contains 3x degenerate repeat unit: PGG gene gene1658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1662 SCO1663 SCO1663 cysS cysS 1783107 1784336 - cysteinyl-tRNA synthetase catalyzes a two-step reaction%3B charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA gene gene1659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1663 SCO1664 SCO1664 SCI52.06c SCI52.06c 1784440 1785237 - hypothetical protein SCI52.06%2C conserved hypothetical protein%2C len: 265 aa%3B similar to TR:O06242 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 28.3 kDa protein MTCY270.35%2C 262 aa%3B fasta scores: opt: 495 Z-score: 595.6 bits: 117.9 E(): 1.4e-25%3B 50.951%25 identity in 263 aa overlap gene gene1660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1664 SCO1665 SCO1665 SCI52.07c SCI52.07c 1785234 1785824 - hypothetical protein SCI52.07c%2C conserved hypothetical protein%2C len: 196 aa%3B similar to TR:O06241 (EMBL:Z95388)Mycobacterium tuberculosis hypothetical 21.2 kDa protein MTCY270.34%2C 195 aa%3B fasta scores: opt: 409 Z-score: 445.1 bits: 89.2 E(): 3.3e-17%3B 54.639%25 identity in 194 aa overlap gene gene1661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1665 SCO1666 SCO1666 SCI52.08c SCI52.08c 1785910 1786596 - phosphatase SCI52.08c%2C possible phosphatase%2C len: 228 aa%3B similar to SW:COBC_ECOLI (EMBL:U23163) Escherichia coli alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.*) CobC or PhpB or B0638%2C aa%3B fasta scores: opt: 212 Z-score: 252.7 bits: 53.8 E(): 1.7e-06%3B 29.412%25 identity in 187 aa overlap and to TR:O06240 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 21.5 kDa protein MTCY270.33%2C 250 aa%3B fasta scores: opt: 725 Z-score: 836.0 bits: 162.0 E(): 5.5e-39%3B 51.923%25 identity in 208 aa overlap. Contains Pfam match to entry PF00300 PGAM%2C Phosphoglycerate mutase family gene gene1662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1666 SCO1667 SCO1667 SCI52.09 SCI52.09 1786649 1787653 + ion transport protein SCI52.09%2C possible ion transport protein%2C len: 334 aa%3B similar to SW:CORA_ECOLI (EMBL:L11042) Escherichia coli magnesium and cobalt transport protein CorA%2C 316 aa%3B fasta scores: opt: 281 Z-score: 338.8 bits: 71.0 E(): 2.7e-11%3B 25.418%25 identity in 299 aa overlap and to TR:Q9FBK1 (EMBL:AL390975) Streptomyces coelicolor metal-transport protein SCP8.20c%2C 371 aa%3B fasta scores: opt: 1166 Z-score: 1386.9 bits: 265.1 E(): 1.1e-69%3B 53.801%25 identity in 342 aa overlap. Contains Pfam match to entry PF01544 CorA%2C CorA-like Mg2+ transporter and possible hydrophobic membranes spanning regions in the C-terminal domain gene gene1663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1667 SCO1668 SCO1668 SCI52.10c SCI52.10c 1787668 1788456 - hypothetical protein SCI52.10c%2C unknown%2C len: 262 aa gene gene1664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1668 SCO1669 SCO1669 SCI52.11c SCI52.11c 1788693 1789748 - ATP/GTP-binding protein SCI52.11c%2C possible ATP/GTP-binding protein%2C len: 351 aa%3B similar to TR:O53565 (EMBL:AL022022) Mycobacterium tuberculosis hypothetical 37.6 kDa protein MTV023.27c%2C 347 aa%3B fasta scores: opt: 859 Z-score: 986.1 bits: 190.9 E(): 2.4e-47%3B 41.449%25 identity in 345 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1669 SCO1670 SCO1670 SCI52.12 SCI52.12 1789862 1790848 + oxidoreductase SCI52.12%2C possible oxidoreductase%2C len: 328 aa%3B similar to TR:Q44328 (EMBL:AF242881) Agrobacterium radiobacter MocA protein%2C 354 aa%3B fasta scores: opt: 708 Z-score: 822.0 bits: 160.5 E(): 3.3e-38%3B 41.246%25 identity in 337 aa overlap gene gene1666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1670 SCO1671 SCO1671 SCI52.13 SCI52.13 1790845 1793163 + hypothetical protein SCI52.13%2C hypothetical protein%2C len: 772 aa%3B N-terminal region (first 89 aa) similar to N-terminal region of TR:O05479 (EMBL:M86351) Streptomyces sp. hypothetical protein 481 aa and rest of the CDS similar to C-terminal region of TR:Q9RT63 (EMBL:AE002029) Deinococcus radiodurans exodeoxyribonuclease V%2C subunit RecD%2C DR1902%2C 715 aa%3B fasta scores: opt: 298 Z-score: 242.2 bits: 55.5 E(): 6.5e-06%3B 31.023%25 identity in 577 aa overlap gene gene1667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1671 SCO1672 SCO1672 SCI52.14c SCI52.14c 1793226 1794029 - hypothetical protein SCI52.14c%2C unknown%2C len: 267 aa. Contains 6x degenerate repeat unit:(T/G)(D/E)LD gene gene1668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1672 SCO1673 SCO1673 SCI52.15 SCI52.15 1794077 1794265 + hypothetical protein SCI52.15%2C hypothetical protein%2C len: 62 aa%3B low similarity to TR:Q9CC44 (EMBL:AL583921) Mycobacterium leprae hypothetical protein ML1294%2C 84 aa%3B fasta scores: opt: 139 Z-score: 215.3 bits: 43.8 E(): 0.0002%3B 44.000%25 identity in 50 aa overlap gene gene1669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1673 SCO1674 SCO1674 SCI52.16c SCI52.16c 1794330 1795109 - hypothetical protein SCI52.16c%2C possible hypothetical protein%2C len: 259 aa%3B similar to TR:Q9X7U2 (EMBL:AL049863) Streptomyces coelicolor hypothetical 22.7 kDa protein SC5H1.35c%2C 237 aa%3B fasta scores: opt: 566 Z-score: 369.4 bits: 75.8 E(): 5.3e-13%3B 46.154%25 identity in 260 aa overlap. High content in glycine amino acid residues. Also contains the following repeats: 2x(SPGV-SGN-V--P--VPVNVCGN--DVVG-LNP--GN-C-N-GGG) and 4x(GG-) and a possible N-terminal region signal peptide sequence gene gene1670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1674 SCO1675 SCO1675 SCI52.17c SCI52.17c 1795289 1795522 - small membrane protein SCI52.17c%2C possible small membrane protein%2C len: 77 aa%3B similar to TR:Q9KYH3 (EMBL:AL356595) Streptomyces coelicolor small hypothetical protein SCC61A.20%2C 91 aa%3B fasta scores: opt: 366 Z-score: 390.2 bits: 76.6 E(): 5.1e-16%3B 73.333%25 identity in 75 aa overlap and to TR:Q9L1J9 (EMBL:AL139164) Streptomyces coelicolor small hypothetical protein SCC46.02c%2C 75 aa%3B fasta scores: opt: 323 Z-score: 394.8 bits: 77.1 E(): 2.1e-14%3B 68.493%25 identity in 73 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1675 SCO1676 SCO1676 SCI52.18c SCI52.18c 1795655 1796992 - hypothetical protein SCI52.18c%2C possible peptidase%2C len: 445 aa%3B similar to TR:Q9CC46 (EMBL:AL583921) Mycobacterium leprae possible peptidase ML1288%2C 467 aa%3B fasta scores: opt: 1595 Z-score: 1853.9 bits: 352.3 E(): 1.1e-95%3B 54.788%25 identity in 449 aa overlap%2C to SW:ACY1_PIG (EMBL:D13514) Sus scrofa aminoacylase-1 (EC 3.5.1.14) Acy1%2C 406 aa%3B fasta scores: opt: 368 Z-score: 430.7 bits: 88.7 E(): 2.1e-16%3B 27.563%25 identity in 439 aa overlap and to TR:Q9ZBI7 (EMBL:AL035161) Streptomyces coelicolor aminoacylase SC9C7.23%2C 444 aa%3B fasta scores: opt: 1543 Z-score: 1530.3 bits: 292.3 E(): 1.6e-79%3B 54.795%25 identity in 438 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20%2C Peptidase family M20/M25/M40 and match to Prosite entry PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1 gene gene1672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1676 SCO1677 SCO1677 SCI52.19 SCI52.19 1797321 1797695 + hypothetical protein SCI52.19%2C conserved hypothetical protein%2C len: 124 aa%3B similar to TR:BAB35158 (EMBL:AP002556) Escherichia coli O157:H7 hypothetical 17.0 kDa protein ECS1735%2C 152 aa%3B fasta scores: opt: 397 Z-score: 489.0 bits: 96.3 E(): 1.2e-19%3B 52.033%25 identity in 123 aa overlap gene gene1674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1677 SCO1678 SCO1678 SCI52.20c SCI52.20c 1797723 1798424 - transcriptional regulator SCI52.20c%2C probable transcriptional regulator%2C len: 233 aa%3B similar to TR:O50536 (EMBL:AJ003022) Streptomyces coelicolor sporulation transcriptional factor WhiH%2C 295 aa%3B fasta scores: opt: 432 Z-score: 525.2 E(): 1.1e-21%3B 34.404%25 identity in 218 aa overlap and to SW:DGOR_ECOLI (EMBL:L10328) Escherichia coli galactonate operon transcriptional repressor DgoR or B3694/B3695%2C 229 aa%3B fasta scores: opt: 320 Z-score: 393.0 E(): 2.6e-14%3B 29.808%25 identity in 208 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and possible helix-turn-helix motif at residues 31..52 (+3.18 SD) gene gene1675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1678 SCO1679 SCO1679 SCI52.21 SCI52.21 1798561 1799088 + gluconokinase SCI52.21%2C probable gluconokinase%2C len: 175 aa%3B similar to SW:IDNK_ECOLI (EMBL:U14003) Escherichia coli thermosensitive gluconokinase (EC 2.7.1.12) IdnK or GntV or B4268%2C 187 aa%3B fasta scores: opt: 434 Z-score: 502.9 bits: 99.6 E(): 2e-20%3B 43.125%25 identity in 160 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1679 SCO1680 SCO1680 SCI30A.01 SCI30A.01 1799183 1800580 + gluconate permease SCI30A.01%2C partial CDS%2C probable gluconate permease%2C len: 359aa%3B similar to many eg. SW:GNTT_ECOLI high affinity gluconate transporter from Escherichia coli (437 aa) fasta scores%3B opt: 998%2C z-score: 1067.1%2C E(): 0%2C (42.1%25 identity in 359 aa overlap). Contains possible membrane spanning hydrophobic regions.~SCI52.22%2C probable gluconate permease (fragment)%2C len: >144 aa%3B similar to N-terminal region of SW:GNUT_PSEAE (EMBL:AF026470) Pseudomonas aeruginosa gluconate permease GnuT or PA2322%2C 450 aa%3B fasta scores: opt: 370 Z-score: 442.1 bits: 89.4 E(): 4.8e-17%3B 44.262%25 identity in 122 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1680 SCO1681 SCO1681 SCI30A.02 SCI30A.02 1800620 1801381 + gluconate dehydrogenase SCI30A.02%2C probable gluconate dehydrogenase%2C len: 253 aa%3B similar to many eg. SW:GNO_GLUOX gluconate 5-dehydrogenase from Gluconobacter oxydans (256 aa) fasta scores%3B opt: 985%2C z-score: 1113.1%2C E(): 0%2C (58.0%25 identity in 255 aa overlap). Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase and to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus%2C and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene1678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1681 SCO1682 SCO1682 SCI30A.03 SCI30A.03 1801378 1802454 + zinc-binding alcohol dehydrogenase SCI30A.03%2C probable zinc-binding alcohol dehydrogenase%2C len: 358 aa%3B similar to many both prokaryote and eukaryote e.g. SW:DHSO_BACSU sorbitol dehydrogenase from Bacillus subtilis (352 aa) fasta scores%3B opt: 616%2C z-score: 638.0%2C E(): 3.3e-28%2C (32.7%25 identity in 352 aa overlap) and DHSO_SHEEP sorbitol dehydrogenase from Ovis aries (sheep) (354 aa) fasta scores%3B opt: 606%2C z-score: 627.7%2C E(): 1.2e-27%2C (34.6%25 identity in 344 aa overlap). Conatins Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene1679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1682 SCO1683 SCO1683 SCI30A.04c SCI30A.04c 1802529 1804067 - amino acid permease SCI30A.04c%2C possible amino acid permease%2C len: 512 aa%3B similar to many e.g. TR:Q53148 (EMBL:L24492) ethanolamine permease from Rhodococcus sp. strain NI86/21 (488 aa) fasta scores%3B opt: 266%2C z-score: 293.8%2C E(): 4.9e-09%2C (26.7%25 identity in 397 aa overlap). Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease. Contains possible membrane spanning hydrophobic regions. gene gene1680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1683 SCO1684 SCO1684 SCI30A.05c SCI30A.05c 1804126 1805142 - hypothetical protein SCI30A.05c%2C unknown%2C len: 338aa gene gene1681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1684 SCO1685 SCO1685 SCI30A.06 SCI30A.06 1805384 1806277 + hypothetical protein SCI30A.06%2C possible integral membrane protein%2C len: 297aa%3B similar to many egs. TR:O33234 (EMBL:Z98209) hypothetical protein from Mycobacterium tuberculosis (301 aa) fasta scores%3B opt: 356%2C z-score: 407.0%2C E(): 2.4e-15%2C (31.5%25 identity in 289 aa overlap) and TR:O86668 (EMBL:AL031182) integral membrane protein from Streptomyces coelicolor (299 aa) fasta scores%3B opt: 272%2C z-score: 312.9%2C E(): 4.2e-10%2C (31.5%25 identity in 279 aa overlap). gene gene1682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1685 SCO1686 SCO1686 SCI30A.07 SCI30A.07 1806297 1806842 + NTP pyrophosphohydrolase SCI30A.07%2C possible NTP pyrophosphohydrolase%2C len: 181 aa%3B similar to many e.g. TR:Q53738 (EMBL:X92429) from the puromycin biosynthetic pathway of Streptomyces alboniger (152 aa) fasta scores%3B opt: 170%2C z-score: 226.2%2C E(): 2.9e-05%2C (35.7%25 identity in 129 aa overlap). Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein. gene gene1683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1686 SCO1687 SCO1687 SCI30A.08 SCI30A.08 1807505 1807897 + hypothetical protein SCI30A.08%2C membrane protein%2C len: 130 aa%3B similar to SW:YIDH_ECOLI hypothetical protein from Escherichia coli (115 aa) fasta scores%3B opt: 291%2C z-score: 382.3%2C E(): 5.8e-14%2C (47.3%25 identity in 112 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene1684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1687 SCO1688 SCO1688 SCI30A.09 SCI30A.09 1807900 1808241 + hypothetical protein SCI30A.09%2C membrane protein%2C len: 113 aa%3B similar to SW:YU38_MYCTU hypothetical protein from Mycobacterium tuberculosis (122 aa) fasta scores%3B opt: 105%2C z-score: 141.8%2C E(): 1.4%2C (34.2%25 identity in 120 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene1685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1688 SCO1689 SCO1689 SCI30A.10 SCI30A.10 1808375 1809400 + phosphotransferase SCI30A.10%2C possible phosphotransferase%2C len: 341 aa%3B similar to TR:O69727 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (351 aa) fasta scores%3B opt: 872%2C z-score: 1004.6%2C E(): 0%2C (43.1%25 identity in 350 aa overlap). Also weakly similar to TR:Q53826 (EMBL:U13078) capreomycin phopshotransferase from Streptomyces capreolus (281 aa) fasta scores%3B opt: 142%2C z-score: 169.4%2C E(): 0.042%2C (29.1%25 identity in 172 aa overlap). gene gene1686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1689 SCO1690 SCO1690 SCI30A.11 SCI30A.11 1809406 1810620 + acyl-CoA dehydrogenase SCI30A.11%2C possible acyl-CoA dehydrogenase%2C len: 404 aa%3B varying similarity to many e.g. TR:P96831 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (403 aa) fasta scores%3B opt: 1464%2C z-score: 1688.2%2C E(): 0%2C (57.3%25 identity in 400 aa overlap) and SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores%3B opt: 465%2C z-score: 539.6%2C E(): 1e-22%2C (32.0%25 identity in 347 aa overlap). Contains two Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene1687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1690 SCO1691 SCO1691 SCI30A.12c SCI30A.12c 1810631 1811386 - TetR family transcriptional regulator SCI30A.12c%2C possible tetR transcriptional regulator%2C len: 251 aa%3B similar to many e.g. SW:BM3R_BACME transcriptional repressor from Bacillus megaterium (192 aa) fasta scores%3B opt: 190%2C z-score: 227.2%2C E(): 2.5e-05%2C (26.7%25 identity in 176 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and Prosite match to PS01081 Bacterial regulatory proteins%2C tetR family signature. Contains possible helix-turn-helix motif (+3.97 SD) 87-108aa. gene gene1688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1691 SCO1692 SCO1692 SCI30A.13c SCI30A.13c 1811383 1812153 - oxidoreductase SCI30A.13c%2C possible oxidoreductase%2C len: 256 aa%3B similar to many e.g. SW:FABG_ECOLI 3-oxoacyl-(carrier protein) reductase from Escherichia coli (244 aa) fasta scores%3B opt: 239%2C z-score: 270.9%2C E(): 9.2e-08%2C (27.3%25 identity in 198 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene1689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1692 SCO1693 SCO1693 SCI30A.14c SCI30A.14c 1812259 1813536 - hypothetical protein SCI30A.14c%2C unknown%2C len: 425aa gene gene1690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1693 SCO1694 SCO1694 SCI30A.15c SCI30A.15c 1813616 1816297 - penicillin acylase SCI30A.15c%2C possible penicillin acylase%2C len: 893 aa%3B similar to many eg. SW:PAC_ARTVI penicillin acylase from Arthrobacter viscosus (ATCC 15294) (802 aa) fasta scores%3B opt: 379%2C z-score: 409.2%2C E(): 1.8e-15%2C (25.5%25 identity in 733 aa overlap). gene gene1691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1694 SCO1695 SCO1695 SCI30A.16 SCI30A.16 1816646 1817248 + hypothetical protein SCI30A.16%2C unknown%2C len: 200aa gene gene1692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1695 SCO1696 SCO1696 SCI30A.17 SCI30A.17 1817349 1818083 + hypothetical protein SCI30A.17%2C unknown%2C len: 244 aa%3B similar to TR:P71976 (EMBL:Z81360) hypothetical protein from Mycobacterium tuberculosis (272 aa) fasta scores%3B opt: 192%2C z-score: 223.1%2C E(): 4.3e-05%2C (26.7%25 identity in 236 aa overlap) and to TR:Q98JP6 (EMBL:AP002998) Rhizobium loti (Mesorhizobium loti) MLL1845 241 aa%3B fasta scores: opt: 534 Z-score: 595.0 E(): 1.7e-25%3B 41.564%25 identity in 243 aa overlap gene gene1693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1696 SCO1697 SCO1697 SCI30A.18c SCI30A.18c 1818351 1818878 - MerR family transcriptional regulator SCI30A.18c%2C probable merR-family transcriptional regulator%2C len: 175aa%3B similar to many egs. TR:CAA09641 (EMBL:AJ011500) from Streptomyces violaceoruber Tu22 (196 aa) fasta scores%3B opt: 698%2C z-score: 833.1%2C E(): 0%2C (64.1%25 identity in 167 aa overlap) and SW:SOXR_ECOLI SoxR transcriptional regulator from Escherichia coli (154 aa) fasta scores%3B opt: 575%2C z-score: 689.9%2C E(): 4.3e-31%2C (60.3%25 identity in 146 aa overlap). Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family. gene gene1694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1697 SCO1698 SCO1698 SCI30A.19 SCI30A.19 1819009 1819470 + hypothetical protein SCI30A.19%2C unknown%2C len: 153 aa%3B similar to many of undefined function e.g. TR:P96807 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (151 aa) fasta scores%3B opt: 639%2C z-score: 785.9%2C E(): 0%2C (60.8%25 identity in 148 aa overlap) and SW:NODN_RHILV nodulation protein from Rhizobium leguminosarum (161 aa) fasta scores%3B opt: 388%2C z-score: 482.2%2C E(): 1.6e-19%2C (44.8%25 identity in 145 aa overlap) gene gene1695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1698 SCO1699 SCO1699 SCI30A.20c SCI30A.20c 1819461 1820108 - transcriptional regulator SCI30A.20c%2C possible transcriptional regulator%2C len: 215 aa%3B similar to many e.g. TR:CAB39717 (EMBL:AL049485) regulatory protein from Streptomyces coelicolor (223 aa) fasta scores%3B opt: 330%2C z-score: 413.5%2C E(): 1.1e-15%2C (33.8%25 identity in 216 aa overlap) and TR:AAD13556 (EMBL:AF080235) LanK regulator of landomycin biosynthesis in Streptomyces cyanogenus S136 (192 aa) fasta scores%3B opt: 170%2C z-score: 218.6%2C E(): 7.6e-05%2C (31.8%25 identity in 154 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Contains possible helix-turn-helix motif (+4.32 SD) 43-64aa. gene gene1696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1699 SCO1700 SCO1700 SCI30A.21c SCI30A.21c 1820169 1820483 - hypothetical protein SCI30A.21c%2C membrane protein%2C len: 104 aa. Contains possible hydrophobic membrane spanning regions gene gene1697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1700 SCO1701 SCO1701 SCI30A.22c SCI30A.22c 1820559 1821710 - acyl-CoA dehydrogenase SCI30A.22c%2C probable acyl-CoA dehydrogenase%2C len: 383 aa%3B similar to many both prokaryote and eukaryote eg. SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores%3B opt: 109%2C1 z-score: 1197.8%2C E(): 0%2C (43.8%25 identity in 377 aa overlap) and SW:ACDS_RAT acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa) fasta scores%3B opt: 1079%2C z-score: 1184.2%2C E(): 0%2C (44.6%25 identity in 372 aa overlap). Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase. gene gene1698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1701 SCO1702 SCO1702 SCI30A.23 SCI30A.23 1821800 1822441 + transcriptional regulator SCI30A.23%2C possible transcriptional regulator%2C len: 213 aa%3B similar to many e.g. TR:Q53901 (EMBL:M64683) regulatory protein from Streptomyces coelicolor (259 aa) fasta scores%3B opt: 227%2C z-score: 273.2%2C E(): 6.9e-08%2C (32.3%25 identity in 217 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and Prosite match to PS01081 Bacterial regulatory proteins%2C tetR family signature. Contains possible helix-turn-helix motif (+5.17 SD) 31-52aa. gene gene1699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1702 SCO1703 SCO1703 SCI30A.24 SCI30A.24 1822505 1823218 + transcriptional regulator SCI30A.24%2C possible transcriptional regulator%2C len: 237aa%3B similar to many eg. SW:MERR_STRLI probable mercury resistance operon repressor from Streptomyces lividans (125 aa) fasta scores%3B opt: 144%2C z-score: 183.3%2C E(): 0.007%2C (38.2%25 identity in 89 aa overlap). Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. Contains possible helix-turn-helix motif (+3.92 SD) 37-58aa. gene gene1700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1703 SCO1704 SCO1704 SCI30A.25 SCI30A.25 1823292 1824266 + hypothetical protein SCI30A.25%2C possible integral membrane conserved hypothetical protein%2C len: 324aa%3B similar to many eg. SW:YDFC_BACSU hypothetical protein from Bacillus subtilis (306 aa) fasta scores%3B opt: 485%2C z-score: 529.4%2C E(): 3.7e-22%2C (34.2%25 identity in 269 aa overlap). Contains 2 Pfam matches to entry PF00892 DUF6%2C Integral membrane protein and several possible membrane spanning hydrophobic regions. gene gene1701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1704 SCO1705 SCO1705 SCI30A.26c SCI30A.26c 1824517 1825614 - alcohol dehydrogenase SCI30A.26c%2C probable alcohol dehydrogenase (zinc-binding)%2C len: 365 aa%3B similar to many e.g. SW:ADH3_ECOLI alcohol dehydrogenase class III from Escherichia coli (369 aa) fasta scores%3B opt: 819%2C z-score: 864.3%2C E(): 0%2C (38.6%25 identity in 368 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and Prosite matche to PS00059 Zinc-containing alcohol dehydrogenases signature. gene gene1702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1705 SCO1706 SCO1706 SCI30A.27c SCI30A.27c 1825638 1827026 - aldehyde dehydrogenase SCI30A.27c%2C probable aldehyde dehydrogenase%2C len: 462 aa%3B similar to many e.g. TR:O33455 (EMBL:U24215) P-cumic aldehyde dehydrogenase from Pseudomonas putida Fl (494 aa) fasta scores%3B opt: 1109%2C z-score: 1142.8%2C E(): 0%2C (44.6%25 identity in 471 aa overlap) and TR:O88069 (EMBL:AL031541) aldehyde dehydrogenase from Streptomyces coelicolor (483 aa) fasta scores%3B opt: 1011%2C z-score: 1042.5%2C E(): 0%2C (41.8%25 identity in 466 aa overlap). Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site. gene gene1703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1706 SCO1707 SCO1707 SCI30A.28c SCI30A.28c 1827151 1828488 - ABC sugar transporter%2C ATP-binding subunit SCI30A.28c%2C probable ABC sugar transporter%2C ATP-binding subunit%2C len: 445aa%3B similar to many eg. TR:AAD24578 (EMBL:AF126010) trehalose/maltose transport ATP-hydrolysing subunit from hyperthermophilic archaeon Thermococcus litoralis (372 aa) fasta scores%3B opt: 975%2C z-score: 1068.2%2C E(): 0%2C (50.1%25 identity in 335 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1707 SCO1708 SCO1708 SCI30A.29c SCI30A.29c 1828712 1828912 - hypothetical protein SCI30A.29c%2C membrane protein%2C len: 66 aa. Contains possible hydrophobic membrane spanning region gene gene1705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1708 SCO1709 SCO1709 SCI30A.30c SCI30A.30c 1828915 1830306 - integral membrane transport protein SCI30A.30c%2C possible integral membrane transport protein%2C len: 463aa%3B weak similarity to many eg. TR:Q45632 (EMBL:L13418) maltose permease from Bacillus stearothermophilus (394 aa) fasta scores%3B opt: 220%2C z-score: 200.9%2C E(): 0.00074%2C (28.7%25 identity in 363 aa overlap). Contains a 13x9bp degenerate repeat G/S)GA in the C-terminal region similar to one found in the N-terminal region of TR:Q94673 (EMBL:U72957) merozoite surface protein-2 of Plasmodium falciparum (176 aa) fasta scores%3B opt: 237%2C z-score: 219.6%2C E(): 6.7e-05%2C (45.4%25 identity in 97 aa overlap). Also contains possible membrane spanning hydrophobic regions. gene gene1706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1709 SCO1710 SCO1710 SCI30A.31c SCI30A.31c 1830346 1831797 - integral membrane transport protein SCI30A.31c%2C possible integral membrane transport protein%2C len: 483aa%3B similar to SW:CITM_BACSU Mg2+/citrate complex secondary transporter from Bacillus subtilis (433 aa) fasta scores%3B opt: 687%2C z-score: 644.4%2C E(): 1.5e-28%2C (45.7%25 identity in 484 aa overlap). Contains Gly/Ala-rich region 220-250aa. Contains possible membrane spanning hydrophobic regions. gene gene1707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1710 SCO1711 SCO1711 SCI30A.32c SCI30A.32c 1831921 1834164 - dehydrogenase SCI30A.32c%2C possible dehydrogenase%2C len: 747aa%3B similar to many e.g. TR:O53648 (EMBL:AL021928) hypothetical protein from Mycobacterium tuberculosis (762 aa) fasta scores%3B opt: 617%2C z-score: 625.8%2C E(): 1.6e-27%2C (29.9%25 identity in 762 aa overlap) and SW:FDHF_ECOLI formate dehydrogenase from Escherichia coli (715 aa) fasta scores%3B opt: 466%2C z-score: 473.3%2C E(): 4.9e-19%2C (24.0%25 identity in 716 aa overlap). gene gene1708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1711 SCO1712 SCO1712 SCI11.01c SCI11.01c 1834289 1834906 - TetR family transcriptional regulator SCI11.01c%2C possible tetR-family transcriptional regulator%2C partial CDS%2C len: >158 aa%3B weakly similar to many plasmid tetracycline repressor proteins e.g. SW:TER1_ECOLI (EMBL:X61367)%2C TetR%2C Escherichia coli plasmid RP1 (216 aa)%2C fasta scores%3B opt: 150 z-score: 196.6 E(): 0.0013%2C 32.8%25 identity in 122 aa overlap. Also similar to TR:O54102 (EMBL:AL021529) S.coelicolor transcriptional regulator (198 aa) (31.9%25 identity in 72 aa overlap). An alternative start codon is present at codon 4. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family~SCI30A.33c%2C partial CDS%2C unknown%2C len: >80 aa gene gene1709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1712 SCO1713 SCO1713 SCI11.02c SCI11.02c 1834903 1835007 - hypothetical protein SCI11.02c%2C hypothetical protein%2C len: 34 aa%3B unknown function%2C improbable CDS suggested by positions of start and stop codons gene gene1710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1713 SCO1714 SCO1714 SCI11.03c SCI11.03c 1835004 1835573 - hypothetical protein SCI11.03c%2C possible hypothetical protein%2C len: 189 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains a probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C so may be a lipoprotein gene gene1711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1714 SCO1715 SCO1715 hgd hgd 1835784 1837109 + homogentisate 1%2C2-dioxygenase An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine gene gene1712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1715 SCO1716 SCO1716 SCI11.05 SCI11.05 1837136 1837885 + GntR family transcriptional regulator SCI11.05%2C possible gntR-family transcriptional regulator%2C len: 249 aa%3B weakly similar to many trancriptional regulators e.g. SW:FARR_ECOLI (EMBL:X15790)%2C FarR%2C Escherichia coli fatty acyl responsive regulator (240 aa)%2C fasta scores%3B opt: 213 z-score: 265.9 E(): 1.8e-07%2C 25.0%25 identity in 232 aa overlap. Similar to others from S.coelicolor e.g. SCE39.14c (EMBL:AL049573) S.coelicolor possible gntR-family regulator (243 aa) (29.5%25 identity in 224 aa overlap). Contains probable helix-turn-helix motif at aa 42-63 (Score 1296%2C +3.60 SD). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene1713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1716 SCO1717 SCO1717 SCI11.06 SCI11.06 1837893 1839068 + hypothetical protein SCI11.06%2C hypothetical protein%2C len: 391 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene1714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1717 SCO1718 SCO1718 SCI11.07c SCI11.07c 1839094 1839798 - regulator SCI11.07c%2C possible regulator%2C len: 234 aa%3B similar to transcriptional regulators e.g. TR:O52558 (EMBL:AF040570)%2C RifQ%2C Amycolatopsis mediterranei repressor in rafamycin biosynthetic cluster (242 aa)%2C fasta scores%3B opt: 325 z-score: 405.5 E(): 3e-15%2C 33.6%25 identity in 229 aa overlap. Similar to others from S.coelicolor e.g. SCI30A.23 S.coelicolor possible transcriptional regulator (213 aa) (30.7%25 identity in 218 aa overlap) gene gene1715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1718 SCO1719 SCO1719 SCI11.08 SCI11.08 1839862 1840860 + ABC transporter ATP-binding protein SCI11.08%2C possible ABC-transporter ATP-binding protein%2C len: 332 aa%3B similar to members of the ABC-transporter superfamily e.g. SW:DRRA_STRPE (EMBL:M73758)%2C drrA%2C Streptomyces peucetius daunorubicin resistance ATP-binding protein (330 aa)%2C fasta scores%3B opt: 901 z-score: 964.0 E(): 0%2C 50.6%25 identity in 316 aa overlap. Similar to many from S.coelicolor e.g. SCE9.25c (EMBL:AL049841) S.coelicolor probable ABC transporter ATP-binding component (315 aa) (57.1%25 identity in 308 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1719 SCO1720 SCO1720 SCI11.09 SCI11.09 1840857 1841672 + ABC-transporter transmembrane protein SCI11.09%2C possible ABC-transporter transmembrane protein%2C len: 271 aa%3B similar to transmembrane subunits of members of the ABC-transporter superfamily e.g SW:DRRB_STRPE (EMBL:M73758)%2C drrB%2C Streptomyces peucetius daunorubicin resistance transmembrane protein (283 aa)%2C fasta scores%3B opt: 467 z-score: 550.2 E(): 2.6e-23%2C 34.0%25 identity in 244 aa overlap. Similar to many others from S.coelicolor e.g. SCE9.24c (EMBL:AL049841) S.coelicolor probable ABC transporter transmembrane component (260 aa) (41.8%25 identity in 268 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene1717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1720 SCO1721 SCO1721 SCI11.10c SCI11.10c 1841897 1842166 - hypothetical protein SCI11.10c%2C hypothetical protein%2C len: 89 aa%3B unknown function%2C possible CDS suggested by GC frameplot gene gene1718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1721 SCO1722 SCO1722 SCI11.11c SCI11.11c 1842282 1843034 - hypothetical protein SCI11.11c%2C possible membrane protein%2C len: 250 aa%3B unknown function%2C similar%2C except at the N-terminus%2C to SW:Y24K_STRGR (EMBL:X15060) Streptomyces griseus hypothetical protein (238 aa)%2C fasta scores%3B opt: 274 z-score: 308.4 E(): 7.6e-10%2C 33.0%25 identity in 176 aa overlap. Also similar to TR:O53729 (EMBL:AL021932) mycobacterium tuberculosis hypothetical protein (232 aa) (31.1%25 identity in 241 aa overlap). Contains a hydrophobic%2C possible membrane-spanning region gene gene1719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1722 SCO1723 SCO1723 SCI11.12c SCI11.12c 1843031 1843588 - RNA polymerase sigma factor SigK Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B in M. bovis this protein has been shown to be involved in expression of antigenic proteins gene gene1720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1723 SCO1724 SCO1724 SCI11.13 SCI11.13 1843788 1845440 + Ser/Thr protein kinase SCI11.13%2C probable Ser/Thr protein kinase%2C len: 550 aa%3B similar to eukaryotic-type protein kinases e.g. SW:PKAA_STRCO (EMBL:D86821)%2C PkaA%2C Streptomyces coelicolor Ser/Thr protein kinase (543 aa)%2C fasta scores%3B opt: 628 z-score: 420.3 E(): 4.4e-16%2C 39.0%25 identity in 364 aa overlap%2C but divergent at C-terminus. Similar to many Ser/Thr protein kinases e.g. TR:O83032 (EMBL:AB016932)%2C PkaD%2C S.coelicolor Ser/Thr protein kinase (598 aa) (49.5%25 identity in 444 aa overlap). Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain%2C PS00108 Ser/Thr protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature gene gene1721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1724 SCO1725 SCO1725 SCI11.14c SCI11.14c 1845443 1846249 - hydrolase SCI11.14c%2C possible hydrolase%2C len: 268 aa%3B similar to TR:Q59837 (EMBL:X92765)%2C estA%2C Streptomyces diastatochromogenes esterase A (326 aa)%2C fasta scores%3B opt: 147 z-score: 171.2 E(): 0.033%2C 26.8%25 identity in 314 aa overlap. The difference in length is accounted for by internal deletions in this protein%2C relative to TR:Q59837. The active-site serine motif GDSYT in the S.diastatochromogenes enzyme is conserved in this protein. Contains a probable N-terminal signal sequence gene gene1722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1725 SCO1726 SCO1726 SCI11.15 SCI11.15 1846435 1847529 + ATPase SCI11.15%2C possible ATPase%2C len: 364 aa%3B unknown function%2C very weak similarity to eukaryotic ATPases e.g. TR:P78787 (EMBL:D89136) Schizosaccharomyces pombe ATPase (partial CDS) (419 aa)%2C fasta scores%3B opt: 184 z-score: 216.6 E(): 9.9e-05%2C 26.5%25 identity in 309 aa overlap and to part of SW:AFG2_YEAST (EMBL:L14615)%2C Agf2%2C Saccharomyces cerevisiae ATPase essential for viability (780 aa) (29.9%25 identity in 137 aa overlap). Contains weak Pfam match to entry PF00004 AAA%2C ATPases associated with various cellular activities (AAA) and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1726 SCO1727 SCO1727 SCI11.16 SCI11.16 1847564 1848331 + hypothetical protein SCI11.16%2C conserved hypothetical protein%2C len: 255 aa%3B unknown function%2C similar hypothetical proteins e.g. TR:O67070 (EMBL:AE000714) Aquifex aeolicus hypothetical protein (252 aa)%2C fasta scores%3B opt: 459 z-score: 574.9 E(): 1.1e-24%2C 33.0%25 identity in 230 aa overlap and the N-terminal half of SW:YECE_ECOLI (EMBL:AE000280) Escherichia coli hypothetical protein (272 aa) (29.0%25 identity in 155 aa overlap). Similar to TR:Q9ZBF5 (EMBL:AL035206) S. coelicolor hypothetical protein (292 aa) (32.2%25 identity in 283 aa overlap) gene gene1724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1727 SCO1728 SCO1728 SCI11.17c SCI11.17c 1848412 1848816 - GntR family transcriptional regulator SCI11.17c%2C possible gntR-family transcriptional regulator%2C len: 134 aa%3B weakly similar to the N-terminal half of SW:HUTC_PSEPU (EMBL:M33922)%2C HutC%2C Pseudomonas putida histidine utilization repressor (248 aa)%2C fasta scores%3B opt: 164 z-score: 202.7 E(): 0.00059%2C 33.9%25 identity in 109 aa overlap. Similar to many transcriptional regulators e.g. SCGD3.13 (EMBL:AL096822) S.coelicolor probable gntR-family transcriptional regulator (115 aa) (32.4%25 identity in 111 aa overlap) and to TR:O06550 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical protein (121 aa) (50.0%25 identity in 106 aa overlap). Contains probable helix-turn-helix motif at aa 106-127 (Score 1082%2C +2.87 SD). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene1725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1728 SCO1729 SCO1729 SCI11.18 SCI11.18 1848849 1849775 + hypothetical protein SCI11.18%2C hypothetical protein%2C len: 308 aa%3B unknown function%2C N-terminal half weakly similar to parts of other hypothetical proteins e.g. TR:O32075 (EMBL:Z99119) Bacillus subtilis hypothetical protein (173 aa)%2C fasta scores%3B opt: 148 z-score: 187.8 E(): 0.004%2C 28.0%25 identity in 168 aa overlap. Weakly similar to TR:Q9ZBG7 (EMBL:AL035206) S.coelicolor hypothetical protein (319 aa) (30.1%25 identity in 272 aa overlap). Contains weak Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1729 SCO1730 SCO1730 SCI11.19 SCI11.19 1849756 1850256 + hypothetical protein SCI11.19%2C hypothetical protein%2C len: 166 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Overlaps the upstream CDS by 6 codons gene gene1727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1730 SCO1731 SCO1731 SCI11.20c SCI11.20c 1850270 1850887 - hypothetical protein SCI11.20c%2C hypothetical protein%2C len: 205 aa%3B weakly similar to parts of many hypothetical proteins%2C many of which resemble methyltransferases e.g. TR:Q48938 (EMBL:X93084) Methanosarcina barkeri ORF3 from molybdenum formylmethanofuran dehydrogenase cluster (262 aa)%2C fasta scores%3B opt: 445 z-score: 518.9 E(): 1.4e-21%2C 37.8%25 identity in 193 aa overlap. Weak similarity to many others from S.coelicolor e.g. TR:Q9ZC03 (EMBL:AL033505) S.coelicolor hypothetical protein (273 aa) (35.2%25 identity in 142 aa overlap) gene gene1728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1731 SCO1732 SCO1732 SCI11.21 SCI11.21 1851039 1851173 + hypothetical protein SCI11.21%2C hypothetical protein%2C len: 44 aa%3B unknown function%2C possible CDS suggested by GC frameplot and the presence of a possible RBS gene gene1729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1732 SCO1733 SCO1733 SCI11.22c SCI11.22c 1851199 1851669 - acetyltransferase SCI11.22c%2C possible acetyltransferase%2C len: 156 aa%3B unknown function%2C weakly similar to TR:Q51670 (EMBL:U34346) Paracoccus denitrificans hypothetical protein (173 aa)%2C fasta scores%3B opt: 144 z-score: 184.8 E(): 0.0058%2C 28.9%25 identity in 149 aa overlap. Very weak similarity to some acetyltransferases e.g. SW:IAAT_AZOBR (EMBL:X57853) Azospirillum brasilense IAA acetyltransferase (153 aa) (26.1%25 identity in 111 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1733 SCO1734 SCO1734 SCI11.23 SCI11.23 1851848 1852918 + cellulose-binding protein SCI11.23%2C possible cellulose-binding protein%2C len: 356 aa%3B similar cellulose-binding proteins e.g. TR:O07862 (EMBL:U51222) Streptomyces halstedii cellulose-binding protein (364 aa)%2C fasta scores%3B opt: 584 z-score: 557.4 E(): 1e-23%2C 35.7%25 identity in 305 aa overlap. Weaker similarity to chitin-binding proteins e.g. TR:O87962 (EMBL:Y14315) Streptomyces reticuli chitin-binding protein (201 aa) (32.7%25 identity in 214 aa overlap) when co-cultivated with chitin-containing fungi. Weak similarity to TR:O86614 (EMBL:AL031155) S.coelicolor possible chitinase (252 aa) (28.9%25 identity in 266 aa overlap). Contains a probable N-terminal signal sequence%2Ca possible hydrophobic membrane spanning region at the C-terminal domain and 6x G(D/S) repeats starting at codon 215 gene gene1731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1734 SCO1735 SCO1735 SCI11.24c SCI11.24c 1853026 1853898 - lipase SCI11.24c%2C probable lipase%2C len: 290 aa%3B similar to many lipases e.g. TR:O33969 (EMBL:U80063)%2C lipA%2C Streptomyces cinnamoneus lipase (275 aa)%2C fasta scores%3B opt: 575 z-score: 653.1 E(): 4.8e-29%2C 47.6%25 identity in 254 aa overlap. Contains probable N-terminal signal sequence gene gene1732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1735 SCO1736 SCO1736 SCI11.25c SCI11.25c 1854078 1854524 - MarR family transcriptional regulator SCI11.25c%2C possible marR-family transcriptional regulator%2C len: 148 aa%3B weakly similar to hypothetical proteins e.g. SW:YW06_MYCTU (EMBL:Z74025) Mycobacterium tuberculosis hypothetical protein (143 aa)%2C fasta scores%3B opt: 159 z-score: 204.1 E(): 0.00049%2C 31.9%25 identity in 135 aa overlap. An alternative start codon is present at codon 7. Contains probable helix-turn-helix motif at aa 53-74 (Score 1261%2C +3.48 SD). Contains Pfam match to entry PF01047 MarR%2C MarR family. Contains possible N-terminal region signal peptide sequence gene gene1733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1736 SCO1737 SCO1737 SCI11.26 SCI11.26 1854635 1855009 + hypothetical protein SCI11.26%2C hypothetical protein%2C len: 124 aa%3B unknown function%2C similar to TR:O86372 (EMBL:AL022003) Mycobacterium tuberculosis hypothetical protein (116 aa)%2C fasta scores%3B opt: 129 z-score: 177.0 E(): 0.016%2C 34.7%25 identity in 98 aa overlap gene gene1734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1737 SCO1738 SCO1738 SCI11.27c SCI11.27c 1855022 1855990 - hypothetical protein SCI11.27c%2C conserved hypothetical protein%2C len: 322 aa%3B similar to many hypothetical proteins related to the impB/mucB/samB family e.g. TR:Q10787 (EMBL:Z74020) Mycobacterium tuberculosis hypothetical protein (463 aa)%2C fasta scores%3B opt: 330 z-score: 372.5 E(): 2.1e-13%2C 29.5%25 identity in 281 aa overlap gene gene1735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1738 SCO1739 SCO1739 SCI11.28c SCI11.28c 1855987 1859544 - DNA polymerase III subunit alpha SCI11.28c%2C probable DNA polymerase III%2C alpha chain%2C len: 1185 aa%3B similar to many e.g. SW:DP3A_ECOLI (EMBL:M19334)%2C dnaE%2C Escherichia coli DNA polymerase III%2C alpha chain (1160 aa)%2C fasta scores%3B opt: 1177 z-score: 1220.7 E(): 0%2C 28.4%25 identity in 1135 aa overlap gene gene1736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1739 SCO1740 SCO1740 SCI11.29 SCI11.29 1859718 1860782 + hypothetical protein SCI11.29%2C possible membrane protein%2C len: 354 aa%3B unknown function%2C weakly similar to TR:O07424 (EMBL:Z97050) Mycobacterium tuberculosis possible membrane protein (452 aa)%2C fasta scores%3B opt: 190 z-score: 202.3 E(): 0.00062%2C 25.9%25 identity in 409 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene1737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1740 SCO1741 SCO1741 SCI11.30c SCI11.30c 1860897 1861979 - serine protease SCI11.30c%2C probable serine protease%2C len: 360 aa%3B highly similar to many serine proteases e.g. SW:PRTD_STRGR (EMBL:L29019)%2C sprD%2C Streptomyces griseus serine protease D precursor (392 aa)%2C fasta scores%3B opt: 1703 z-score: 1655.9 E(): 0%2C 67.1%25 identity in 392 aa overlap. Similar to S.coelicolor SCI11.35c%2C sal%2C serine protease (300 aa) (52.2%25 identity in 278 aa overlap). Contains a probable N-terminal signal sequence. Contains probable coiled-coil from 84 to 119 (36 residues) (Max score: 1.468%2C probability 0.91). Contains Pfam match to entry PF00089 trypsin%2C Trypsin%2C PS00134 Serine proteases%2C trypsin family%2C histidine active site and PS00135 Serine proteases%2C trypsin family%2C serine active site gene gene1738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1741 SCO1742 SCO1742 SCI11.31 SCI11.31 1862249 1863169 + ABC transporter ATP-binding protein SCI11.31%2C probable ABC-transporter ATP-binding protein%2C len: 319 aa%3B similar to SW:BCRA_BACLI (EMBL:L20573)%2C bcrA%2C Bacillus licheniformis bacitracin transport ATP-binding protein (306 aa)%2C fasta scores%3B opt: 561 z-score: 595.7 E(): 7.5e-26%2C 36.2%25 identity in 298 aa overlap and to many ABC-transporter ATP-binding proteins. Similar to others from S.coelicolor e.g. SCE8.17C (EMBL:AL035654) S.coelicolor probable ABC transporter ATP-binding protein (317 aa) (45.9%25 identity in 296 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1742 SCO1743 SCO1743 SCI11.32 SCI11.32 1863166 1863885 + ABC-transporter transmembrane protein SCI11.32%2C possible ABC-transporter transmembrane protein%2C len: 239 aa%3B weakly similar to ABC-transporter from S.coelicolor TR:O69995 (EMBL:AL022374) S.coelicolor probable ABC transporter (744 aa)%2C fasta scores%3B opt: 197 z-score: 224.6 E(): 3.5e-05%2C 35.4%25 identity in 212 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions. May be associated with the adjacent ABC-transporter ATP-binding protein gene gene1740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1743 SCO1744 SCO1744 SCI11.33 SCI11.33 1863882 1865048 + two-component system sensor kinase SCI11.33%2C possible two-component system sensor kinase%2C len: 388 aa%3B similar to may sensor kinases e.g. to the N-terminus of TR:Q53893 (EMBL:AL035654)%2C AbsA1%2C S.coelicolor two-component system sensor kinase involved in global regulation of antibiotic synthesis (571 aa)%2C fasta scores%3B opt: 361 z-score: 391.6 E(): 1.8e-14%2C 31.6%25 identity in 364 aa overlap. The C-terminus is similar to part of SW:NARX_ECOLI (EMBL:X13360)%2C NarX%2C NarR%2C Escherichia coli nitrate/nitrite sensor protein (598 aa) (30.7%25 identity in 218 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains probable coiled-coil from 157 to 189 (33 residues) (Max score: 1.493%2C probability 0.94) gene gene1741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1744 SCO1745 SCO1745 SCI11.34 SCI11.34 1865045 1865710 + two-component system response regulator SCI11.34%2C probable two-component system response regulator%2C len: 221 aa%3B similar to SW:NARL_ECOLI (EMBL:X13360)%2C NarL%2C Escherichia coli nitrate/nitrite response regulator protein (216 aa)%2C fasta scores%3B opt: 482 z-score: 568.4 E(): 2.5e-24%2C 38.9%25 identity in 211 aa overlap and TR:Q53894 (EMBL:AL035654)%2C AbsA2%2C S.coelicolor two-component system response regulator (222 aa) (43.1%25 identity in 218 aa overlap). Contains probable helix-turn-helix motif at aa 171-192 (Score 1021%2C +2.66 SD). Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain and to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature gene gene1742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1745 SCO1746 SCO1746 sal sal 1865777 1866679 - serine protease SCI11.35c%2C sal%2C serine protease%2C len: 300 aa%3B highly similar to extracellular serine proteases from Streptomyces spp. Identical to TR:Q54392 (EMBL:L44109)%2C Sal%2C Streptomyces lividans chymotrypsin-like serine protease (300 aa)%2C fasta scores%3B opt: 1919 z-score: 1861.1 E(): 0%2C 99.7%25 identity in 300 aa overlap. Similar to SCI11.30c S.coelicolor probable serine protease (360 aa) (52.2%25 identity in 278 aa overlap). Contains probable N-terminal signal sequence. Contains Pfam match to entry PF00089 trypsin%2C Trypsin%2C PS00134 Serine proteases%2C trypsin family%2C histidine active site and PS00135 Serine proteases%2C trypsin family%2C serine active site gene gene1743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1746 SCO1747 SCO1747 SCI11.36c SCI11.36c 1866887 1867738 - hypothetical protein SCI11.36c%2C hypothetical protein%2C len: 283 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Similar to TR:Q9PFB7 (EMBL:AE003917) hypothetical protein from Xylella fastidiosa (305 aa) fasta scores%3B opt: 394%2C Z-score: 443.5%2C E(): 4.5e-17%2C 35.094%25 identity (37.805%25 ungapped) in 265 aa overlap. gene gene1744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1747 SCO1748 SCO1748 2SCI34.01c 2SCI34.01c 1867793 1868989 - expression regulator 2SCI34.01c%2C probable expression regulator (fragment)%2C len: >159 aa%3B highly similar to metallothionein-like proteins e.g. TR:Q9WX50 (EMBL:AB012145) Streptomyces lividans MrnA encoding metallothionein-like domain exhibiting repressor function against protease expression%2C 315 aa%3B fasta scores: opt: 507 z-score: 589.0 E(): 2.3e-25%3B 98.8%25 identity in 81 aa overlap~SCI11.37c%2C probable expression regulator%2C partial CDS%2C len: >272 aa%3B highly similar to metallothionein-like proteins e.g. Streptomyces lividans CDS (EMBL:AB012145) exhibiting repressor function against protease expression (315 aa)%2C fasta scores%3B opt: 1943 z-score: 1640.5 E(): 0%2C 97.8%25 identity in 272 aa overlap. The C-terminus contains a Pro-rich region (aa 170-200 approx.)%2C followed by a Cys-rich region (aa 235-272 approx.). Contains PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene1745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1748 SCO1749 SCO1749 2SCI34.02 2SCI34.02 1869279 1869719 + hypothetical protein 2SCI34.02%2C conserved hypothetical protein%2C len: 146 aa%3B similar to TR:O06229 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 27.6 kDa protein MTCY270.21%2C 241 aa%3B fasta scores: opt: 311 z-score: 378.3 E(): 1.3e-13%3B 41.8%25 identity in 141 aa overlap gene gene1746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1749 SCO1750 SCO1750 2SCI34.03c 2SCI34.03c 1869768 1870961 - acyl CoA dehydrogenase 2SCI34.03c%2C probable acyl CoA dehydrogenase%2C len: 397 aa%3B similar to many dehydrogenases%2C e.g. SW:GCDH_HUMAN (EMBL:U69141) Homo sapiens (Human) glutaryl-CoA dehydrogenase%2C mitochondrial precursor (EC 1.3.99.7) GcdH%2C 438 aa%3B fasta scores: opt: 1208 z-score: 1358.9 E(): 0%3B 48.2%25 identity in 398 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene1747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1750 SCO1751 SCO1751 2SCI34.04c 2SCI34.04c 1871317 1872921 - transmembrane transport protein 2SCI34.04c%2C probable transmembrane transport protein%2C len: 534 aa%3B similar to TR:O33968 (EMBL:U80063) Streptomyces cinnamoneus transmembrane%2C proton-dependent transport protein%2C 519 aa%3B fasta scores: opt: 1250 z-score: 1258.8 E(): 0%3B 43.9%25 identity in 513 aa overlap and to SW:SMVA_SALTY (EMBL:D26057) Salmonella typhimurium methyl viologen resistance protein SmvA%2C 496 aa%3B fasta scores: opt: 1018 z-score: 1026.6 E(): 0%3B 37.4%25 identity in 497 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1751 SCO1752 SCO1752 2SCI34.05 2SCI34.05 1873183 1874373 + hypothetical protein 2SCI34.05%2C possible integral membrane protein%2C len: 396 aa%3B similar to TR:Q9L0K6 (EMBL:AL161691) Streptomyces coelicolor integral membrane protein SCD40A.03c%2C 434 aa%3B fasta scores: opt: 678 Z-score: 715.1 E(): 3.4e-32%3B 37.530%25 identity in 413 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1752 SCO1753 SCO1753 2SCI34.06 2SCI34.06 1874625 1875647 + hypothetical protein 2SCI34.06%2C possible integral membrane protein%2C len: 340 aa. Contains Pfam match to entry PF01569 PAP2%2C PAP2 superfamily and possible hydrophobic membrane spanning regions. Also presents high content of alanine%2C arginine%2C leucine and proline amino acid residues gene gene1750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1753 SCO1754 SCO1754 2SCI34.07c 2SCI34.07c 1875760 1875975 - hypothetical protein 2SCI34.07c%2C unknown%2C len: 71 aa gene gene1751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1754 SCO1755 SCO1755 2SCI34.08c 2SCI34.08c 1876319 1877167 - hypothetical protein 2SCI34.08c%2C unknown%2C len: 282 aa%3B similar to TR:CAC47960 (EMBL:AJ320278) Streptomyces avermitilis hypothetical protein%2C 278 aa%3B fasta scores: opt: 962 Z-score: 1035.8 E():4.6e-50%3B 63.441%25 identity in 279 aa overlap gene gene1752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1755 SCO1756 SCO1756 2SCI34.09 2SCI34.09 1877577 1878374 + hypothetical protein 2SCI34.09%2C unknown%2C len: 265 aa gene gene1753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1756 SCO1757 SCO1757 2SCI34.10 2SCI34.10 1878448 1878741 + hypothetical protein 2SCI34.10%2C unknown%2C len: 97 aa gene gene1754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1757 SCO1758 SCO1758 engA engA 1878820 1880298 - GTP-binding protein EngA synchronizes cellular events by interacting with multiple targets with tandem G-domains%3B overexpression in Escherichia coli suppresses rrmJ mutation%3B structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains gene gene1755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1758 SCO1759 SCO1759 2SCI34.12c 2SCI34.12c 1880373 1881035 - transferase 2SCI34.12c%2C possible transferase%2C len: 220 aa%3B similar to TR:O67841 (EMBL:AE000770) Aquifex aeolicus 2-acylglycerophosphoethanolamine acyltransferase Aas%2C 211 aa%3B fasta scores: opt: 325 z-score: 388.0 E(): 3.6e-14%3B 33.3%25 identity in 189 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase%2C Acyltransferase gene gene1756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1759 SCO1760 SCO1760 cmk cmk 1881032 1881727 - cytidylate kinase Catalyzes the formation of (d)CDP from ATP and (d)CMP gene gene1757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1760 SCO1761 SCO1761 2SCI34.14c 2SCI34.14c 1882015 1883100 - prephenate dehydrogenase catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate gene gene1758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1761 SCO1762 SCO1762 SCI51.02c SCI51.02c 1883097 1883459 - chorismate mutase SCI51.02c%2C possible chorismate mutase%2C len: 120 aa%3B similar to e.g. SW:CHMU_BACSU (EMBL:M32278)%2C AroH%2C Bacillus subtilis chorismate mutase (127 aa)%2C fasta scores%3B opt: 307 z-score: 407.7 E(): 2.2e-15%2C 38.1%25 identity in 118 aa overlap gene gene1759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1762 SCO1763 SCO1763 SCI51.03 SCI51.03 1883621 1884016 + iron-sulfur protein SCI51.03%2C possible iron-sulphur protein ( hypothetical protein)%2C len: 131 aa%3B similar to part of many cytochrome B6-F complex iron-sulfur subunits from bacteria and chloroplasts e.g. SW:UCRI_CHLLT (EMBL:X73628)%2C PetC%2C Chlorobium limicola F. sp. thiosulfatophilum iron-sulfur subunit (180 aa)%2C fasta scores%3B opt: 198 z-score: 217.9 E(): 8.2e-05%2C 34.4%25 identity in 90 aa overlap. Similar to TR:Q9Z510 (EMBL:AL035591) Streptomyces coelicolor iron sulphur binding protein (141 aa) (36.6%25 identity in 131 aa overlap). Contains Pfam match to entry PF00355 Rieske%2C Rieske iron-sulfur protein. Contains possible N-terminal region signal peptide sequence gene gene1760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1763 SCO1764 SCO1764 SCI51.04 SCI51.04 1884039 1884800 + hypothetical protein SCI51.04%2C hypothetical protein%2C len: 253 aa%3B unknown function%2C shows weak similarity to TR:P94389 (EMBL:D50453)%2C YcgL%2C Bacillus subtilis hypothetical protein (260 aa)%2C fasta scores%3B opt: 177 z-score: 222.1 E(): 5.1e-05%2C 28.1%25 identity in 196 aa overlap. There is some overlap with the C-terminus of SCI51.5c and weak similarity with SCI51.5c (250 aa) (29.6%25 identity in 233 aa overlap) gene gene1761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1764 SCO1765 SCO1765 SCI51.05c SCI51.05c 1884726 1885478 - hypothetical protein SCI51.05c%2C hypothetical protein%2C len: 250 aa%3B unknown function%2C similar to SW:Y002_METJA (EMBL:U67459) Methanococcus jannaschii hypothetical protein (243 aa)%2C fasta scores%3B opt: 290 z-score: 356.7 E(): 1.6e-12%2C 28.3%25 identity in 223 aa overlap. There is some overlap with the C-terminus of SCI51.04 and weak similarity with SCI51.04 (253 aa) (29.6%25 identity in 233 aa overlap) gene gene1762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1765 SCO1766 SCO1766 SCI51.06c SCI51.06c 1885483 1886502 - glycohydrolase SCI51.06c%2C possible glycohydrolase%2C len: 339 aa%3B shows weak similarity to ADP-ribosyl glycohydrolases from nitrogen-fixing bacteria e.g. SW:DRAG_RHORU (EMBL:X16187)%2C DraG%2C Rhodospirillum rubrum ADP-ribosylglycohydrolase (294 aa)%2C fasta scores%3B opt: 211 z-score: 253.7 E(): 8.9e-07%2C 25.6%25 identity in 332 aa overlap gene gene1763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1766 SCO1767 SCO1767 SCI51.07c SCI51.07c 1886499 1887218 - DNA hydrolase SCI51.07c%2C possible DNA hydrolase%2C len: 239 aa%3B shows weak similarity to nucleotide pyrophosphatases e.g. TR:Q58549 (EMBL:U67557) Methanococcus jannaschii ADP-ribose pyrophosphatase (169 aa)%2C fasta scores%3B opt: 256 z-score: 312.0 E(): 5e-10%2C 43.8%25 identity in 112 aa overlap and SW:MUTX_STRMU (EMBL:D78182)%2C MutX%2C Streptococcus mutans mutator MutT protein (dGTP pyrophosphohydrolase) (159 aa) (30.5%25 identity in 118 aa overlap). Also similar many hypothetical proteins e.g. TR:O69994 (EMBL:AL022374) S.coelicolor possible DNA hydrolase (294 aa) (56.2%25 identity in 249 aa overlap) and TR:O06597 (EMBL:Z95586) Mycobacterium tuberculosis hypothetical protein (236 aa) (34.8%25 identity in 221 aa overlap). Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and PS00893 mutT domain signature gene gene1764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1767 SCO1768 SCO1768 SCI51.08c SCI51.08c 1887312 1888427 - pseudouridine synthase SCI51.08c%2C possible pseudouridine synthase%2C len: 371 aa%3B part of this CDS shows similarity to SW:RSUA_ECOLI (EMBL:U00008)%2C rsuA%2C Escherichia coli ribosomal small subunit pseudouridine synthase A (231 aa)%2C fasta scores%3B opt: 389 z-score: 356.8 E(): 1.6e-12%2C 35.2%25 identity in 233 aa overlap and to many pseudouridine synthases. Similarity to SW:YRSU_MYCLE (EMBL:Z95117) Mycobacterium leprae hypothetical protein (256 aa) (54.6%25 identity in 240 aa overlap) and its Mycobacterium tuberculosis counterpart is high. GC frameplot and an absence of possible start codons suggests that an N-terminal extension of approx. 130 aa is present in this sequence%2C but not in similar sequences. The N-terminus is Ser- and Gly-rich. Contains Pfam matches to entry PF01479 S4%2C S4 domain and to entry PF00849 YABO%2C Hypothetical yabO/yceC/sfhB family. Contains PS01149 RsuA family of pseudouridine synthase signature gene gene1765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1768 SCO1769 SCO1769 SCI51.09c SCI51.09c 1888427 1889098 - hypothetical protein SCI51.09c%2C conserved hypothetical protein%2C len: 223 aa%3B unknown function%2C similar to hypothetical proteins from Mycobacterium leprae and Mycobacterium tuberculosis e.g. TR:O05669 (EMBL:Z95117) Mycobacterium leprae hypothetical protein (231 aa)%2C fasta scores%3B opt: 633 z-score: 766.9 E(): 0%2C 54.5%25 identity in 187 aa overlap gene gene1766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1769 SCO1770 SCO1770 SCI51.10c SCI51.10c 1889095 1889889 - hypothetical protein SCI51.10c%2C conserved hypothetical protein%2C len: 264 aa%3B unknown function%2C similar to hypothetical proteins from Mycobacterium leprae%2C Mycobacterium tuberculosis and Bacillus subtilis e.g. TR:O33208 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (278 aa)%2C fasta scores%3B opt: 875 z-score: 760.8 E(): 0%2C 56.2%25 identity in 267 aa overlap gene gene1767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1770 SCO1771 SCO1771 SCI51.11c SCI51.11c 1890421 1890978 - hypothetical protein SCI51.11c%2C hypothetical protein%2C len: 185 aa%3B unknown function%2C improbable CDS suggested by positional base preference and amino acid composition gene gene1768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1771 SCO1772 SCO1772 SCI51.12c SCI51.12c 1890975 1891997 - partitioning or sporulation protein SCI51.12c%2C possible partitioning or sporulation protein%2C len: 340 aa%3B the C-terminal region is similar to SW:SOJ_BACSU (EMBL:D26185)%2C Soj%2C Bacillus subtilis sporulation protein (253 aa)%2C fasta scores%3B opt: 790 z-score: 857.6 E(): 0%2C 48.8%25 identity in 250 aa overlap and TR:O05189 (EMBL:U87804)%2C ParA%2C Caulobacter crescentus chromosome partitioning protein (266 aa) (46.3%25 identity in 255 aa overlap). It is closer in predicted length to similar proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. TR:O33207 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (318 aa) (65.8%25 identity in 301 aa overlap). Similar to SCH24.08 (EMBL:AL049826) S.coelicolor possible partitioning or sporulation protein (275 aa) (45.8%25 identity in 249 aa overlap) to many other members of the parA family. The start codon position is suggested by GC frameplot and codon usage plots. Alternative start codons are present at codons 3%2C 8 and 11. Contains Pfam match to entry PF00991 ParA%2C ParA family ATPase gene gene1769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1772 SCO1773 SCO1773 SCI51.13c SCI51.13c 1892493 1893608 - L-alanine dehydrogenase SCI51.13c%2C probable L-alanine dehydrogenase%2C len: 371 aa%3B similar to many alanine dehydrogenases e.g. SW:DHA_MYCTU (EMBL:X63069)%2C ald%2C Mycobacterium tuberculosis L-alanine dehydrogenase (371 aa)%2C fasta scores%3B opt: 1569 z-score: 1722.1 E(): 0%2C 65.8%25 identity in 371 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT%2C Alanine dehydrogenase/pyridine nucleotide transhydrogenase and PS00836 Alanine dehydrogenase %26 pyridine nucleotide transhydrogenase signature 1 gene gene1770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1773 SCO1774 SCO1774 SCI51.14c SCI51.14c 1893751 1895799 - regulatory protein SCI51.14c%2C probable regulatory protein%2C len: 682 aa%3B similar to the C-terminal region of other regulators from S.coelicolor e.g. SW:AFSR_STRCO (EMBL:D90155)%2C AfsR%2C Streptomyces coelicolor global regulatory protein for secondary metabolite formation (993 aa)%2C fasta scores%3B opt: 474 z-score: 505.1 E(): 8.8e-21%2C 27.7%25 identity in 656 aa overlap. The N-terminal and C-terminal regions of AfsR have been shown to direct actinorhodin production independently. The N-terminal half of this protein is also weakly similar to the C-terminal region of TR:Q9Z389 (EMBL:AL035654)%2C CdaR%2C S.coelicolor transcriptional activator protein for CDA biosynthesis (592 aa) (28.6%25 identity in 332 aa overlap) gene gene1771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1774 SCO1775 SCO1775 SCI51.15c SCI51.15c 1895948 1896583 - hypothetical protein SCI51.15c%2C conserved hypothetical protein%2C len: 211 aa%3B unknown function%2C similar to many bacterial hypothetical proteins e.g. TR:O33199 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (207 aa)%2C fasta scores%3B opt: 508 z-score: 616.4 E(): 5.5e-27%2C 43.1%25 identity in 197 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein gene gene1772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1775 SCO1776 SCO1776 pyrG pyrG 1896671 1898320 - CTP synthetase CTP synthase%3B cytidine triphosphate synthetase%3B catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B in Escherichia coli this enzyme forms a homotetramer gene gene1773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1776 SCO1777 SCO1777 SCI51.17 SCI51.17 1898870 1900708 + hypothetical protein SCI51.17%2C conserved hypothetical protein%2C len: 612 aa%3B unknown function%2C similar to TR:P71741 (EMBL:Z81368) Mycobacterium tuberculosis hypothetical protein (642 aa)%2C fasta scores%3B opt: 1146 z-score: 1320.1 E(): 0%2C 40.6%25 identity in 623 aa overlap and SW:YAY3_SCHPO (EMBL:Z69380) Schizosaccharomyces pombe hypothetical protein (649 aa) (33.5%25 identity in 641 aa overlap). Also similar to SCE36.11C (EMBL:AL049763) S.coelicolor conserved hypothetical protein (fragment) (612 aa) (42.6%25 identity in 615 aa overlap) gene gene1774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1777 SCO1778 SCO1778 SCI51.18 SCI51.18 1901295 1902941 + transcriptional regulator SCI51.18%2C possible transcriptional regulator%2C len: 548 aa%3B shows weak similarity to TR:Q00509 (EMBL:X63451)%2C SmrR%2C Streptomyces ambofaciens regulatory gene governing the expression of a polyketide synthase (604 aa)%2C fasta scores%3B opt: 205 z-score: 220.9 E(): 5.9e-05%2C 26.5%25 identity in 460 aa overlap. Also similar to TR:O69807 (EMBL:AL023496) Streptomyces coelicolor hypothetical protein (537 aa) (32.4%25 identity in 547 aa overlap) and PkwR (EMBL:AF115313) Thermomonospora curvata regulatory protein (535 aa) (28.8%25 identity in 534 aa overlap). Contains probable helix-turn-helix motif at aa 498-519 (Score 1712 (+5.02 SD) gene gene1775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1778 SCO1779 SCO1779 SCI51.19c SCI51.19c 1902964 1904169 - hypothetical protein SCI51.19c%2C hypothetical protein%2C len: 401 aa%3B unknown function%2C C-terminus shows weak similarity to SW:YPJH_BACSU (EMBL:L47709)%2C YpjH%2C Bacillus subtilis hypothetical protein (377 aa)%2C fasta scores%3B opt: 211 z-score: 223.0 E(): 1e-05%2C 28.0%25 identity in 193 aa overlap. Shows similarity to TR:Q9Z5B7 (EMBL:AL035478) S.coelicolor possible transferase (402 aa) (31.9%25 identity in 407 aa overlap). Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene1776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1779 SCO1780 SCO1780 SCI51.20c SCI51.20c 1904440 1906158 - DNA repair protein SCI51.20c%2C possible DNA repair protein%2C len: 572 aa%3B similar to SW:RECN_ECOLI (EMBL:Y00357)%2C recN%2C Escherichia coli DNA repair protein (553 aa)%2C fasta scores%3B opt: 425 z-score: 428.6 E(): 3.6e-17%2C 33.1%25 identity in 568 aa overlap and to recN homologues. Contains probable coiled-coils from 155 to 189 (35 residues) (Max score: 1.472%2C probability 0.91) and from 336 to 376 (41 residues) (Max score: 1.517%2C probability 0.96). Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1780 SCO1781 SCO1781 ppnK ppnK 1906323 1907228 - inorganic polyphosphate/ATP-NAD kinase catalyzes the phosphorylation of NAD to NADP gene gene1778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1781 SCO1782 SCO1782 SCI51.22c SCI51.22c 1907225 1908040 - hypothetical protein SCI51.22c%2C possible membrane protein%2C len: 271 aa%3B unknown function%2C similar to hemolysins and hemolysin-like hypothetical proteins e.g. SW:HLYA_TREHY (EMBL:X61684)%2C tlyA%2C Treponema hyodysenteriae hemolysin A (240 aa)%2C fasta scores%3B opt: 457 z-score: 532.9 E(): 2.5e-22%2C 35.4%25 identity in 240 aa overlap and TR:Q50760 (EMBL:X98295)%2C tlyA%2C Mycobacterium tuberculosis. Contains a hydrophobic%2C possible membrane-spanning region. Contains Pfam match to entry PF01479 S4%2C S4 domain and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1782 SCO1783 SCO1783 SCI51.23c SCI51.23c 1908048 1908395 - hypothetical protein SCI51.23c%2C hypothetical protein%2C len: 115 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. The C-terminus is Pro-rich gene gene1780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1783 SCO1784 SCO1784 SCI51.24 SCI51.24 1908438 1908785 + hypothetical protein SCI51.24%2C hypothetical protein%2C len: 115 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene1781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1784 SCO1785 SCO1785 SCI51.25c SCI51.25c 1908769 1909674 - iron-siderophore uptake system ATP-binding protein SCI51.25c%2C probable iron-siderophore uptake system ATP-binding component%2C len: 301 aa%3B similar to many ATP-binding components from binding-protein-dependent iron uptake systems using a range of siderophores e.g. SW:FEPC_ECOLI (EMBL:X57471)%2C fepC%2C Escherichia coli ferric enterobactin transport ATP-binding protein (271 aa)%2C fasta scores%3B opt: 1101 z-score: 1184.4 E(): 0%2C 61.5%25 identity in 260 aa overlap. Similar to other binding-protein-dependent permease subunits e.g. SC9B1.09 (EMBL:AL049727) S.coelicolor ABC transporter ATP-binding subunit (386 aa) (37.7%25 identity in 228 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene1782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1785 SCO1786 SCO1786 SCI51.26c SCI51.26c 1909671 1910798 - iron-siderophore uptake system transmembrane protein SCI51.26c%2C probable iron-siderophore uptake system transmembrane component%2C len: 375 aa%3B similar to many transmembrane components from binding-protein-dependent iron uptake systems using a range of siderophores e.g. SW:FEPG_ECOLI (EMBL:X57471)%2C fepG%2C Escherichia coli ferric enterobactin transport protein (330 aa)%2C fasta scores%3B opt: 946 z-score: 1034.3 E(): 0%2C 50.0%25 identity in 310 aa overlap. Similar to neighbouring SCI51.27c%2C probable iron-siderophore uptake system transmembrane component (348 aa) (37.9%25 identity in 348 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF01032 FecCD_family%2C FecCD transport family gene gene1783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1786 SCO1787 SCO1787 SCI51.27c SCI51.27c 1910795 1911841 - iron-siderophore uptake system transmembrane protein SCI51.27c%2C probable iron-siderophore uptake system transmembrane component%2C len: 348 aa%3B similar to many transmembrane components from binding-protein-dependent iron uptake systems using a range of siderophores e.g. SW:FEPD_ECOLI (EMBL:X57471)%2C fepD%2C Escherichia coli ferric enterobactin transport protein (334 aa)%2C fasta scores%3B opt: 910 z-score: 991.5 E(): 0%2C 46.0%25 identity in 326 aa overlap. Similar to neighbouring SCI51.26c%2C probable iron-siderophore uptake system transmembrane component (375 aa) (37.9%25 identity in 348 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF01032 FecCD_family%2C FecCD transport family gene gene1784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1787 SCO1788 SCO1788 SCI51.28c SCI51.28c 1911986 1913017 - hypothetical protein SCI51.28c%2C conserved hypothetical protein%2C len: 343 aa%3B unknown function%2C similar to other hypothetical proteins e.g. TR:O33194 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (353 aa)%2C fasta scores%3B opt: 768 z-score: 825.7 E(): 0%2C 44.8%25 identity in 315 aa overlap%2C with SCI51.28c. Also shows weak similarity to SW:NAGD_ECOLI (EMBL:X14135)%2C nagD%2C a CDS in the Escherichia coli N-acetylglucosamine operon (250 aa) (26.7%25 identity in 243 aa overlap) and to SW:PNPP_SCHPO (EMBL:X62722) Schizosaccharomyces pombe 4-nitrophenylphosphatase (unknown physiological substrate) (269 aa) (27.7%25 identity in 238 aa overlap) gene gene1785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1788 SCO1789 SCO1789 SCI51.29 SCI51.29 1913090 1914382 + hypothetical protein SCI51.29%2C hypothetical protein%2C len: 430 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene1786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1789 SCO1790 SCO1790 SCI51.30c SCI51.30c 1914468 1915100 - hypothetical protein SCI51.30c%2C conserved hypothetical protein%2C len: 210 aa%3B unknown function%2C similar to part of TR:O33193 (EMBL:Z98268) Mycobacterium tuberculosis hypothetical protein (250 aa)%2C fasta scores%3B opt: 560 z-score: 665.7 E(): 1e-29%2C 49.7%25 identity in 185 aa overlap. The start codon is uncertain gene gene1787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1790 SCO1791 SCO1791 SCI51.31c SCI51.31c 1915097 1916356 - hypothetical protein SCI51.31c%2C hypothetical protein%2C len: 419 aa%3B unknown function%2C improbable CDS containing Thr- and Val-rich repeats and having a Ser- and Arg-rich C-terminus. Due to the unusual base composition in this region this assignment should be treated with caution gene gene1788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1791 SCO1792 SCO1792 SCI51.32c SCI51.32c 1922128 1922769 - 3-methyladenine DNA glycosylase responsible for recognizing base lesions in the genome and initiating base excision DNA repair gene gene1792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1792 SCO1793 SCO1793 SCI5.01 SCI5.01 1922916 1923698 + hypothetical protein SCI5.01%2C partial CDS%2C unknown%2C len: >195aa%3B similar to TR:O87735 (EMBL:D89936) sporulation control protein Spo0M from Bacillus subtilis (258 aa) fasta scores%3B opt: 283%2C z-score: 342.4%2C E(): 9.7e-12%2C (32.7%25 identity in 153 aa overlap).~SCI51.33%2C hypothetical protein%2C partial CDS%2C len: >98 aa%3B unknown function%2C similar to TR:O87735 (EMBL:D89936)%2C Spo0M%2C Bacillus subtilis sporulation-control protein (258 aa)%2C fasta scores%3B opt: 214 z-score: 268.2 E(): 1.4e-07%2C 34.8%25 identity in 92 aa overlap. Continues in cosmid I5 as SCI5.01 (EMBL:AL079332) S.coelicolor hypothetical protein (195 aa). Contains possible N-terminal region signal peptide sequence gene gene1793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1793 SCO1794 SCO1794 SCI5.02 SCI5.02 1923750 1924289 + hypothetical protein SCI5.02%2C conserved hypothetical protein%2C len: 179 aa%3B similar to many eg. TR:O06235 (EMBL:Z95388) hypothetical protein from Mycobacterium tuberculosis (176 aa) fasta scores%3B opt: 581%2C z-score: 658.0%2C E(): 2.6e-29%2C (52.9%25 identity in 172 aa overlap) gene gene1794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1794 SCO1795 SCO1795 SCI5.03 SCI5.03 1924446 1924952 + hypothetical protein SCI5.03%2C unknown%2C len: 168 aa%3B similar to TR:P72833 (EMBL:D90901) hypothetical protein from Synechocystis sp. PCC6803 (165 aa) fasta scores%3B opt: 417%2C z-score: 517.5%2C E(): 1.7e-21%2C (46.9%25 identity in 143 aa overlap) gene gene1795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1795 SCO1796 SCO1796 SCI5.04c SCI5.04c 1925094 1926053 - hypothetical protein SCI5.04c%2C hypothetical protein%2C len: 319 aa%3B similar to many e.g. SW:YS09_MYCTU hypothetical protein from Mycobacterium tuberculosis (381 aa) fasta scores%3B opt: 956%2C z-score: 915.0%2C E(): 0%2C 55.3%25 identity in 311 aa overlap. Contains Pfam match to PF01145 and Prosite match to PS01270 Band 7 protein family signature. Contains possible N-terminal region signal peptide sequence gene gene1796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1796 SCO1797 SCO1797 SCI5.05c SCI5.05c 1926231 1926662 - hypothetical protein SCI5.05c%2C possible integral membrane protein%2C len: 143aa%3B similar to TR:P71767 (EMBL:Z79701) hypothetical protein from Mycobacterium tuberculosis (144 aa) fasta scores%3B opt: 344%2C z-score: 409.3%2C E(): 1.8e-15%2C (44.8%25 identity in 134 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene1797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1797 SCO1798 SCO1798 SCI5.06c SCI5.06c 1926717 1927514 - ABC transporter ATP-binding protein SCI5.06c%2C possible ABC transporter ATP-binding subunit%2C len: 265aa%3B similar to many egs. TR:O53288 (EMBL:AL021287) predicted ABC transporter ATP-binding subunit (287 aa) fasta scores%3B opt: 893%2C z-score: 998.3%2C E(): 0%2C (53.3%25 identity in 257 aa overlap) and SW:LIVG_SALTY high-affinity branched-chain amino acid transporter from Salmonella typhimurium (255 aa) fasta scores%3B opt: 343%2C z-score: 390.2%2C E(): 2.1e-14%2C (31.0%25 identity in 248 aa overlap). Contains Pfam match to PF00005 ABC transporter transmembrane region and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1798 SCO1799 SCO1799 SCI5.07 SCI5.07 1927668 1928447 + hypothetical protein SCI5.07%2C unknown%2C len: 259 aa%3B similar to SW:YS07_MYCTU hypothetical protein from Mycobacterium tuberculosis (302 aa) fasta scores%3B opt: 131%2C z-score: 146.5%2C E(): 0.79%2C (32.3%25 identity in 279 aa overlap). gene gene1799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1799 SCO1800 SCO1800 SCI5.08c SCI5.08c 1928593 1928841 - hypothetical protein SCI5.08c%2C possible small hypothetical protein%2C len: 82aa%3B contains possible N-terminal signal sequence. gene gene1800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1800 SCO1801 SCO1801 SCI5.09c SCI5.09c 1929011 1929643 - two component response regulator SCI5.09c%2C possible two component response regulator%2C len: 210aa%3B similar to many eg. TR:CAB42027 (EMBL:AL049754) two component response regulator from Streptomyces coelicolor (228 aa) fasta scores%3B opt: 622%2C z-score: 715.0%2C E(): 1.7e-32%2C (48.6%25 identity in 214 aa overlap) and SW:NARL_ECOLI nitrite/nitrate response regulator from Escherichia coli (216 aa) fasta scores%3B opt: 512%2C z-score: 591.0%2C E(): 1.4e-25%2C (39.9%25 identity in 203 aa overlap). Contains Pfam matches to PF00196 Bacterial regulatory proteins%2C luxR family and PF00072 Response regulator receiver domain%2C and Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains probable helix-turn-helix 165-186aa (+3.23 SD). gene gene1801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1801 SCO1802 SCO1802 SCI33.01c SCI33.01c 1929645 1930823 - two-component system sensor kinase SCI33.01c%2C possible two-component system sensor kinase (fragment)%2C len: >383 aa%3B similar to N-terminal region of TR:Q9L1F1 (EMBL:AL157916) Streptomyces coelicolor two-component system sensor kinase SC3D11.11%2C 442 aa%3B fasta scores: opt: 406 z-score: 434.9 E(): 1.1e-16%3B 38.9%25 identity in 211 aa overlap. Contains Pfam matches to entries PF01590 GAF%2C GAF domain and PF02518 HATPase_c%2C GAF domain~SCI5.10c%2C partial CDS%2C possible two component sensor kinase%2C len: >41aa%3B similar to the C-terminus of many egs. TR:Q52558 (EMBL:U02041) VsrA%2C virulence regulator from Ralstonia solanacearum (502 aa) fasta scores%3B opt: 115%2C z-score: 182.8%2C E(): 0.0074%2C (51.4%25 identity in 35 aa overlap) and SW:DEGS_BACBR DegS%2C sensor kinase from Bacillus brevis (386 aa) fasta scores%3B opt: 111%2C z-score: 178.6%2C E(): 0.013%2C (44.1%25 identity in 34 aa overlap). gene gene1802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1802 SCO1803 SCO1803 SCI33.02 SCI33.02 1931041 1931736 + oxidoreductase SCI33.02%2C possible oxidoreductase%2C len: 231 aa%3B similar to TR:Q9KAS7 (EMBL:AP001514) Bacillus halodurans 3-oxoacyl-(acyl-carrier-protein) reductase BH2210%2C 244 aa%3B fasta scores: opt: 369 z-score: 399.8 E(): 1e-14%3B 35.3%25 identity in 235 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene1803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1803 SCO1804 SCO1804 SCI33.03 SCI33.03 1931736 1932812 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase SCI33.03%2C possible S-adenosylmethionine:tRNA ribosyltransferase-isomerase%2C len: 358 aa%3B similar to SW:QUEA_ECOLI (EMBL:M37702) Escherichia coli S-adenosylmethionine:tRNA ribosyltransferase-isomerase QueA%2C 356 aa%3B fasta scores: opt: 232 z-score: 260.0 E(): 6.3e-07%3B 27.6%25 identity in 373 aa overlap gene gene1804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1804 SCO1805 SCO1805 SCI33.04 SCI33.04 1933166 1933900 + hypothetical protein SCI33.04%2C possible membrane protein%2C len: 244 aa%3B C-terminal region highly similar to TR:Q9XAS4 (EMBL:AL078618) Streptomyces coelicolor hypothetical 17.2 kDa protein SC10A7.01%2C 163 aa%3B fasta scores: opt: 620 z-score: 633.5 E(): 9.9e-28%3B 63.1%25 identity in 157 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1805 SCO1806 SCO1806 SCI33.05c SCI33.05c 1934027 1936657 - ABC transporter ATP-binding protein SCI33.05c%2C conserved hypothetical protein%2C len: 876 aa%3B similar to TR:O65934 (EMBL:Z95890) Mycobacterium tuberculosis hypothetical 92.2 kDa protein MTCY28.10%2C 865 aa%3B fasta scores: opt: 1196 z-score: 907.2 E(): 0%3B 37.8%25 identity in 883 aa overlap and to TR:AAK46062 (EMBL:AE007039) Mycobacterium tuberculosis ABC transporter%2C ATP-binding protein MT1789%2C 863 aa%3B fasta scores: opt: 1196 Z-score: 892.8 E(): 4.3e-42%3B 37.826%25 identity in 883 aa overlap. Contains 2x Pfam matches to entry PF00498 FHA%2C FHA domain (N-terminal region) and Pfam match to entry PF00005 ABC_tran%2C ABC transporter (C-terminal region) and Prosite matches to entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains possible hydrophobic membrane spanning regions at C-terminal domain gene gene1806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1806 SCO1807 SCO1807 SCI28.01 SCI28.01 1936844 1938898 + hypothetical protein SCI28.01%2C possible integral membrane protein%2C len: 684 aa%3B similar to TR:Q9X7S6 (EMBL:AL049863) Streptomyces coelicolor membrane protein SC5H1.18%2C 400 aa%3B fasta scores: opt: 550 Z-score: 394.9 E(): 2.3e-14%3B 36.636%25 identity in 434 aa overlap. Contains possible membrane spanning hydrophobic regions up to about 500 aa then a hydrophilic C-terminal tail gene gene1807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1807 SCO1808 SCO1808 SCI28.02 SCI28.02 1939010 1940242 + phosphoserine phosphatase SCI28.02%2C possible phosphoserine phosphatase%2C len: 410 aa%3B similar to many e.g. SW:SERB_ECOLI phosphoserine phosphatase from Escherichia coli (322 aa) fasta scores%3B opt: 621%2C z-score: 674.7%2C E(): 3e-30%2C (49.8%25 identity in 219 aa overlap). Also similar to TR:O53289 (EMBL:AL021287) hypothetical protein from Mycobacterium tuberculosis (409 aa) fasta scores%3B opt: 1209%2C z-score: 1304.1%2C E(): 0%2C (51.8%25 identity in 400 aa overlap). gene gene1808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1808 SCO1809 SCO1809 SCI28.03c SCI28.03c 1940314 1940832 - hypothetical protein SCI28.03c%2C unknown%2C len: 172aa%3B similar to SW:Y086_MYCTU hypothetical protein from Mycobacterium tuberculosis (158 aa) fasta scores%3B opt: 385%2C z-score: 471.9%2C E(): 5.9e-19%2C (43.5%25 identity in 161 aa overlap). gene gene1809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1809 SCO1810 SCO1810 SCI28.04c SCI28.04c 1940925 1941131 - hypothetical protein SCI28.04c%2C membrane protein%2C len: 68 aa. Contains possible hydrophobic membrane spanning regions gene gene1810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1810 SCO1811 SCO1811 SCI28.05c SCI28.05c 1941315 1941431 - hypothetical protein SCI28.05c%2C membrane protein%2C len: 38 aa. Contains possible hydrophobic membrane spanning regions gene gene1811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1811 SCO1812 SCO1812 SCI28.06c SCI28.06c 1941516 1942781 - integral membrane transporter SCI28.06c%2C possible integral membrane transporter%2C len: 421aa%3B similar to SW:CYNX_ECOLI cyanate transport protein from Escherichia coli (384 aa) fasta scores%3B opt: 328%2C z-score: 364.0%2C E(): 6.1e-13%2C (28.0%25 identity in 386 aa overlap). Also similar to TR:O68332 (EMBL:AF033674) hypothetical protein from Pseudomonas marginalis pv. alfalfae (420 aa) fasta scores%3B opt: 521%2C z-score: 574.2%2C E(): 1.2e-24%2C (37.7%25 identity in 385 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene1812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1812 SCO1813 SCO1813 SCI28.07 SCI28.07 1942957 1943649 + GntR family transcriptional regulator SCI28.07%2C possible gntR-family transcriptional regulator%2C len: 230aa%3B similar to many eg. TR:O33960 (EMBL:U78309) pyruvate dehydrogenase complex repressor from Rhodobacter capsulatus (257 aa) fasta scores%3B opt: 326%2C z-score: 383.3%2C E(): 5.2e-14%2C (34.2%25 identity in 228 aa overlap). Also similar to TR:O68331 (EMBL:AF033674) hypothetical protein from Pseudomonas marginalis pv. alfalfae (217 aa) fasta scores%3B opt: 407%2C z-score: 476.9%2C E(): 3.1e-19%2C (40.4%25 identity in 166 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene1813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1813 SCO1814 SCO1814 inhA inhA 1943738 1944505 - enoyl-ACP reductase Catalyzes a key regulatory step in fatty acid biosynthesis gene gene1814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1814 SCO1815 SCO1815 fabG fabG 1944511 1945215 - 3-oxacyl-ACP reductase gene gene1815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1815 SCO1816 SCO1816 SCI28.10 SCI28.10 1945493 1947016 + hypothetical protein SCI8.01%2C unknown%2C partial CDS%2C len: > 104 aa. Similar to many proteins of undefined function e.g. Mycobacterium tuberculosis TR:P71897 (EMBL%3B Z79702) hypothetical 54.6 KD protein (505 aa)%2C fasta scores opt: 596 z-score: 748.3 E(): 0 79.6%25 identity in 103 aa overlap. Overlaps and extends into CDS SCI28.10 on the adjoining cosmid~SCI28.10%2C partial CDS%2C unknown%2C len: >435aa%3B similar to many of undefined function egs. TR:P71897 (EMBL:Z79702) hypothetical protein from Mycobacterium tuberculosis (505 aa) fasta scores%3B opt: 1767%2C z-score: 2036.8%2C E(): 0%2C (63.3%25 identity in 431 aa overlap) and SW:TLDD_ECOLI TldD protein from Escherichia coli (481 aa) fasta scores%3B opt: 327%2C z-score: 379.0%2C E(): 8.9e-14%2C (28.0%25 identity in 415 aa overlap). gene gene1816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1816 SCO1817 SCO1817 SCI8.02 SCI8.02 1947013 1948407 + hypothetical protein SCI8.02%2C unknown%2C len: 464 aa. Similar to many proteins of undefined function e.g. Mycobacterium tuberculosis TR: P71898 (EMBL%3B Z79702) hypothetical 48.7 KD protein MTCY3G12.20 (457 aa)%2C fasta scores opt: 1485 z-score: 1670.5 E():0 53.5%25 identity in 454 aa overlap. Contains a Pfam match to entry PF01523 PmbA_TldD%2C modulator of DNA gyrase. gene gene1817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1817 SCO1818 SCO1818 tyrS tyrS 1948453 1949721 + tyrosyl-tRNA synthetase SCI8.03%2C tyrS%2C tyrosyl-tRNA synthetase (EC 6.1.1.1)%2C len: 422 aa. Highly similar to many tyrosyl-tRNA synthetases e.g. Escherichia coli SW:SYY_ECOLI (EMBL: J01719) (423 aa)%2C fasta scores opt: 1317 z-score: 1463.3 E():0 48.6%25 identity in 416 aa overlap and Mycobacterium tuberculosis SW:SYY_MYCTU (EMBL: Z98268) (424 aa)%2C fasta scores opt: 1657 z-score: 1839.8 E():0 60.7%25 identity in 422 aa overlap. Contains a Prosite hit to PS00178 Aminoacyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00579 tRNA-synt_1b%2C tRNA synthetases class I (W and Y). gene gene1818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1818 SCO1819 SCO1819 SCI8.04c SCI8.04c 1949812 1950093 - hypothetical protein SCI8.04c%2C possible integral membrane protein%2C len: 93 aa. Similar to Streptomyces coelicolor TR:CAB42957 (EMBL: AL049863) possible membrane protein SC5H1.32 (89 aa)%2C fasta scores opt: 180 z-score: 240.4 E(): 5.1e-06 34.2%25 identity in 76 aa overlap and Escherichia coli SW:TAG1_ECOLI (EMBL: U85771) transglycosylase associated protein (84 aa)%2C fasta scores opt: 166 z-score: 223.5 E(): 4.4e-05 36.4%25 identity in 77 aa overlap. Contains a possible membrane spanning hydrophobic domains. gene gene1819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1819 SCO1820 SCO1820 SCI8.05 SCI8.05 1950275 1950754 + hypothetical protein SCI8.05%2C possible integral membrane protein%2C len: 159 aa. Contains possible membrane spanning hydrophobic domains. gene gene1820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1820 SCO1821 SCO1821 moaA moaA 1951220 1952245 - molybdenum cofactor biosynthesis protein A together with moaC%2C is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z gene gene1821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1821 SCO1822 SCO1822 SCI8.07c SCI8.07c 1952378 1954012 - transmembrane transport protein SCI8.07c%2C possible transmembrane transport protein%2C len: 544 aa. A member of the sodium:solute symporter family it is similar to many including: Streptomyces coelicolor TR:O70003 (EMBL: AL022374) transmembrane transport SC5B8.17 (530 aa)%2C fasta scores opt: 2215 z-score: 2454.2 E(): 0 64.5%25 identity in 527 aa overlap and Pseudomonas putida TR:O50471 (EMBL: Z71176) phenylacetic acid permease (520 aa)%2C fasta scores opt: 1004 z-score: 1114.3 E():0 46.3%25 identity in 527 aa overlap. Contains a Pfam match to entry PF00474 SSF%2C Sodium:solute symporter family and multiple possible membrane spanning hydrophobic domains. gene gene1822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1822 SCO1823 SCO1823 SCI8.08c SCI8.08c 1954009 1954383 - hypothetical protein SCI8.08c%2C possible integral membrane protein%2C len: 124 aa. Similar to the C-terminus of Streptomyces coelicolor TR:O70002 (EMBL: AL022374) hypothetical 20.6 KD protein SC5B8.16 (192 aa)%2C fasta scores opt: 268 z-score: 343.6 E(): 9.1e-12 36.9%25 identity in 111 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene1823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1823 SCO1824 SCO1824 ssp ssp 1954737 1956275 + subtilisin-like protease SCI8.09%2C ssp%2C subtilisin-like protease%2C len: 512 aa. Almost identical to the Streptomyces lividans TR:Q54400 (EMBL: L41655) subtilisin-like protease precursor (512 aa)%2C fasta scores opt: 3375 z-score: 3428.7 E(): 0 99.6%25 identity in 512 aa overlap. Contains a Pfam match to entry PF00082 Peptidase_S8%2C Subtilase family and Prosite hits to PS00137 Serine proteases%2C subtilase family%2C histidine active site%2C PS00138 Serine proteases%2C subtilase family%2C serine active site and PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site. Also contains a possible N-terminal signal sequence. gene gene1824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1824 SCO1825 SCO1825 SCI8.10 SCI8.10 1956291 1956929 + hypothetical protein SCI8.10%2C possible membrane protein%2C len: 212 aa. Contains a possible membrane spanning hydrophobic domain. gene gene1825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1825 SCO1826 SCO1826 SCI8.11 SCI8.11 1956980 1957987 + hypothetical protein SCI8.11%2C possible membrane protein%2C len: 335 aa. Contains multiple possible membrane spanning hydrophobic domains. gene gene1826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1826 SCO1827 SCO1827 SCI8.12 SCI8.12 1958139 1959125 + DNA polymerase III subunit epsilon 3'-5' exonuclease of DNA polymerase III gene gene1827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1827 SCO1828 SCO1828 SCI8.13 SCI8.13 1959189 1959422 + hypothetical protein SCI8.13%2C unknown%2C len: 77 aa. gene gene1828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1828 SCO1829 SCO1829 SCI8.14 SCI8.14 1959486 1960358 + hypothetical protein SCI8.14%2C possible membrane protein%2C len: 290 aa. Weakly similar to several proteins of undefined function e.g. Streptomyces coelicolor TR:CAB45478 (EMBL: AL079348) hypothetical 30.3 KD protein SC66T3.22 (278 aa)%2C fasta scores opt: 394 z-score: 463.3 E(): 1.9e-18 33.8%25 identity in 272 aa overlap and Mycobacterium leprae TR:O69480 (EMBL: AL023635) hypothetical 30.0 KD protein (270 aa)%2C fasta scores opt: 392 z-score: 461.2 E(): 2.5e-18 30.7%25 identity in 270 aa overlap. Note it is possible that codon 28 may be the true translational start site. Contains a possible membrane spanning hydrophobic domain gene gene1829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1829 SCO1830 SCO1830 SCI8.15 SCI8.15 1960424 1962211 + hypothetical protein SCI8.15%2C unknown%2C len: 595 aa. Similar to several proteins of unknown function from Streptomyces coelicolor%2C including TR:CAB52841 (EMBL: AL109848) hypothetical 68.4 KD protein SCI51.17 (612 aa)%2C fasta scores pt: 2473 z-score: 2932.7 E(): 0 60.7%25 identity in 596 aa overlap and TR:CAB42080 (EMBL: AL049763) conserved hypothetical protein SCE36.11C (612 aa) fasta scores opt: 1389 z-score: 1396.7 E():0 45.8%25 identity in 605 aa overlap. As well as Mycobacterium tuberculosis TR:P71741 (EMBL%3B Z81368) hypothetical 72.7 KD protein (642 aa)%2C fasta scores opt: 1152 z-score: 1364.6 E(): 0 39.9%25 identity in 622 aa overlap. gene gene1830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1830 SCO1831 SCO1831 SCI8.16 SCI8.16 1962217 1962972 + oxidoreductase SCI8.16%2C possible oxidoreductase%2C len: 251 aa. Similar to several including Streptomyces coelicolor TR:CAB52925 (EMBL: AL109949) oxidoreductase SCJ11.40 (250 aa)%2C fasta scores opt: 462 z-score: 489.9 E(): 6.4e-20 33.9%25 identity in 248 aa overlap and Bacillus megaterium SW:DHG2_BACME (EMBL: D90044) glucose 1-dehydrogenase II (EC 1.1.1.47) (GLCDH-II) (261 aa)%2C fasta scores opt: 412 z-score: 437.9 E(): 5e-17 34.6%25 identity in 254 aa overlap. Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. gene gene1831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1831 SCO1832 SCO1832 SCI8.17c SCI8.17c 1963007 1963594 - hypothetical protein SCI8.17c%2C possible membrane protein%2C len: 192 aa. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain. gene gene1832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1832 SCO1833 SCO1833 SCI8.18c SCI8.18c 1963591 1964112 - hypothetical protein SCI8.18c%2C possible membrane protein%2C len: 226 aa. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain. gene gene1833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1833 SCO1834 SCO1834 SCI8.19c SCI8.19c 1964268 1964651 - hypothetical protein SCI8.19c%2C unknown%2C len: %2C124 aa. gene gene1834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1834 SCO1835 SCO1835 SCI8.20c SCI8.20c 1964648 1964833 - hypothetical protein SCI8.20c%2C possible membrane protein%2C len: 61 aa. Contains possible membrane spanning hydrophobic domains. gene gene1835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1835 SCO1836 SCO1836 SCI8.21c. SCI8.21c. 1964896 1965378 - stress-like protein SCI8.21c%2C possible stress-like protein%2C len: 160 aa. Similar to several stress proteins e.g. Staphylococcus aureus TR:Q53485 (EMBL: S76213) alkaline shock protein 23 (169 aa)%2C fasta scores opt: 303 z-score: 340.6 E(): 1.3e-11 39.3%25 identity in 150 aa overlap and Enterococcus faecalis TR:O32593 (EMBL: AJ000042) Gls24 general stress protein (180 aa)%2C fasta scores opt: 218 z-score: 249.4 E(): 1.6e-06 31.7%25 identity in 126 aa overlap. gene gene1836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1836 SCO1837 SCO1837 SCI8.22 SCI8.22 1965466 1966254 + hypothetical protein SCI8.22%2C unknown%2C len: 262 aa. gene gene1837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1837 SCO1838 SCO1838 SCI8.23c SCI8.23c 1966275 1967078 - enoyl-CoA hydratase/isomerase SCI8.23c%2C possible enoyl-CoA hydratase/isomerase%2C len: 267 aa. Similar to many including: Mycobacterium tuberculosis TR:P75019 (EMBL: Z80343) hypothetical 29.1 KD protein (274 aa)%2C fasta scores opt: 331 z-score: 381.9 E(): 6.7e-14 33.9%25 identity in 236 aa overlap and Pseudomonas fluorescens TR:O69762 (EMBL: Y13067) P-hydroxycinnamoyl CoA hydratase/lyase (276 aa)%2C fasta scores opt: 278 z-score: 322.1 E(): 1.4e-10 29.7%25 identity in 212 aa overlap. Contains a Pfam match to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family and a Prosite hit to PS00166 Enoyl-CoA hydratase/isomerase signature. gene gene1838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1838 SCO1839 SCO1839 SCI8.24c SCI8.24c 1967236 1967457 - transcriptional regulator SCI8.24c%2C possible transcriptional regulator%2C len: 73 aa. Contains a possible helix-turn-helix motif between residues 32..53 (+3.35 SD). gene gene1839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1839 SCO1840 SCO1840 SCI8.25c SCI8.25c 1967794 1969392 - ABC transporter ATP-binding protein SCI8.25c%2C probable ABC transporter%2C ATP binding subunit%2C len: 532 aa. Highly similar to many e.g. Mycobacterium tuberculosis TR:O53164 (EMBL: AL021184) ABC transporter ATP binding protein (542 aa)%2C fasta scores opt: 2213 z-score: 2308.8 E():0 63.5%25 identity in 542 aa overlap and Escherichia coli SW: YBIT_ECOLI (EMBL: AE000184) ABC transporter ATP-binding protein (530 aa)%2C fasta scores opt: 921 z-score: 963.6 E():0 33.5%25 identity in 534 aa overlap. Contains 2xPfam match to entry PF00005 ABC_tran ABC transporter. In addition to Prosite hits to 2xPS00017 ATP/GTP-binding site motif A (P-loop) and 2xPS00211 ABC transporters family signature. Also contains a probable coiled-coil from 250 to 286 (37 residues). gene gene1840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1840 SCO1841 SCO1841 SCI8.26 SCI8.26 1969468 1970052 + hypothetical protein SCI8.26%2C unknown%2C len: 194 aa. Weakly similar to a protein of unknown function from Mycobacterium tuberculosis: SW:YZ15_MYCTU (EMBL: Z73101) hypothetical 16.1 KD protein precursor (152 aa)%2C fasta scores opt: 220 z-score: 256.4 E(): 6.5e-07 33.6%25 identity in 131 aa overlap. gene gene1841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1841 SCO1842 SCO1842 SCI8.27c SCI8.27c 1970085 1971428 - hypothetical protein SCI8.27c%2C unknown%2C len: 447 aa. Similar to another Streptomyces coelicolor protein of unknown function: TR:CAB46408 (EMBL: AL096743) hypothetical 49.9 KD protein (475 aa)%2C fasta scores opt: 380 z-score: 402.6 E(): 4.8e-15 32.1%25 identity in 492 aa overlap. gene gene1842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1842 SCO1843 SCO1843 SCI8.28c SCI8.28c 1971753 1972880 - hypothetical protein SCI8.28c%2C possible hypothetical protein%2C len: 411 aa%3B similar to TR:Q9RRL1 (EMBL:AE002077) Deinococcus radiodurans hypothetical protein DR2478%2C 407 aa%3B fasta scores: opt: 516 Z-score: 552.7 E(): 3.8e-23%3B 30.469%25 identity in 384 aa overlap. Contains a Prosite hit to PS00120 Lipases%2C serine active site. Contains a possible N-terminal signal sequence gene gene1843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1843 SCO1844 SCO1844 SCI8.29c SCI8.29c 1972995 1973717 - aldolase SCI8.29c%2C possible aldolase%2C len: 240 aa. Similar to many aldolases e.g. Escherichia coli SW:FUCA_ECOLI (EMBL: M31059) L-fuculose phosphate aldolase (EC 4.1.2.17) (215 aa)%2C fasta scores opt: 485 z-score: 552.3 E(): 2.1e-23 42.3%25 identity in 194 aa overlap. Contains a Pfam match to entry PF00596 Aldolase_II%2C Class II Aldolase and Adducin N-terminal domain. gene gene1844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1844 SCO1845 SCO1845 SCI8.30 SCI8.30 1973943 1975214 + low-affinity phosphate transport protein SCI8.30%2C possible low-affinity phosphate transport protein%2C len: 423 aa. Highly similar to many possible transporters%2C including: Streptomyces halstedii SW: PITH_STRHA (EMBL: L05390) low-affinity inorganic phosphate transporter (fragment) (>213 aa)%2C fasta scores opt: 505 z-score: 517.8 E(): 1.8e-21 45.9%25 identity in 194 aa overlap and Mycobacterium tuberculosis TR:O06411 (EMBL: Z95558) hypothetical 42.7 KD protein (417 aa)%2C fasta scores opt: 1286 z-score: 1295.4 E():0 50.8%25 identity in 421 aa overlap. Contains a Pfam match to entry PF01384 PHO4%2C Phosphate transporter family. Also contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene1845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1845 SCO1846 SCO1846 SCI8.31 SCI8.31 1975249 1975470 + hypothetical protein SCI8.31%2C possible membrane protein%2C len: 73 aa. Contains possible hydrophobic membrane spanning regions gene gene1846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1846 SCO1847 SCO1847 cobD cobD 1975869 1976852 + cobalamin biosynthesis protein CobD%3B CbiD in Salmonella%3B converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group gene gene1847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1847 SCO1848 SCO1848 cobQ cobQ 1976849 1978357 + cobyric acid synthase catalyzes amidations at positions B%2C D%2C E%2C and G on adenosylcobyrinic A%2CC-diamide. NH(2) groups are provided by glutamine%2C and one molecule of ATP is hydrogenolyzed for each amidation gene gene1848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1848 SCO1849 SCO1849 cobN cobN 1978354 1982007 + cobaltochelatase subunit CobN with CobST catalyzes the formation of cobyrinic acid a%2Cc-diamide from hydrogenobyrinic acid a%2Cc-diamide in an ATP-dependent manner%3B involved in porphyrin and chlorophyll metabolism%3B vitamin B12 metabolism gene gene1849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1849 SCO1850 SCO1850 SCI8.35 SCI8.35 1982004 1984022 + chelatase SCI8.35%2C possible chelatase%2C len: 672 aa. Highly similar to many magnesium chelatase family proteins e.g. Mycobacterium tuberculosis SW:YS50_MYCTU (EMBL: Z95207) hypothetical 67.0 KD protein (629 aa)%2C fasta scores opt: 1941 z-score: 1746.0 E(): 0 54.7%25 identity in 675 aa overlap and Rhodobacter capsulatus SW:BCHI_RHOCA (EMBL: Z11165) magnesium-chelatase 38 KD subunit (Mg-protoporphyrin IX chelatase) (350 aa)%2C fasta scores opt: 1114 z-score: 1008.8 E(): 0 52.7%25 identity in 332 aa overlap. Contains a Pfam match to entry PF01078 Mg_chelatase%2C Magnesium chelatase%2C subunit ChlI and a possible membrane spanning hydrophobic domain. gene gene1850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1850 SCO1851 SCO1851 cobO cobO 1984022 1984621 + cob(I)yrinic acid a%2Cc-diamide adenosyltransferase catalyzes the formation of adenosylcob(III)yrinic acid a%2Cc-diamide from cob(I)yrinic acid a%2Cc-diamide gene gene1851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1851 SCO1852 SCO1852 cobB cobB 1984618 1986078 + cobyrinic acid a%2Cc-diamide synthase responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid gene gene1852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1852 SCO1853 SCO1853 cobI cobI 1986075 1986806 + precorrin-2 C20-methyltransferase SCI8.38%2C cobI%2C precorrin-2 C20-methyltransferase (EC 2.1.1.130)%2C len: 243 aa. Similar to many including: Pseudomonas denitrificans SW:COBI_PSEDE (EMBL: M59301) precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine-precorrin-2 methyltransferase) (SP2MT) (244 aa)%2C fasta scores opt: 322 z-score: 369.3 E(): 3.3e-13 30.0%25 identity in 240 aa overlap and to the N-terminus of the CobI/J fusion protein from Mycobacterium tuberculosis SW:COBI_MYCTU (EMBL: Z73966) cobalamin biosynthesis protein CobIJ [includes: precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine- precorrin-2 methyltransferase) (SP2MT)%3B precorrin-3 methylase (EC 2.1.1.-)] (508 aa)%2C fasta scores opt: 305 z-score: 345.6 E(): 7e-12 33.1%25 identity in 242 aa overlap. Contains a Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases. gene gene1853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1853 SCO1854 SCO1854 SCI39.01c SCI39.01c 1986827 1987555 - permease SCI39.01c%2C possible integral membrane protein (fragment)%2C len: >174 aa. Contains possible hydrophobic membrane spanning regions~SCI8.39%2C possible permease%2C partial CDS%2C len: > 104 aa. Weakly similar to Escherichia coli SW:BTUC_ECOLI (EMBL: M14031) vitamin B12 transport system permease (326 aa)%2C fasta scores opt: 101 z-score: 140.5 E():1.9 32.5%25 identity in 77 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene1854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1854 SCO1855 SCO1855 SCI39.02 SCI39.02 1987618 1988463 + precorrin-4 C11-methyltransferase SCI39.02%2C probable precorrin-4 C11-methyltransferase%2C len: 281 aa%3B similar to TR:O87696 (EMBL:AJ000758) Bacillus megaterium precorrin-4 methylase CbiF%2C 258 aa%3B fasta scores: opt: 674 Z-score: 771.2 bits: 150.4 E(): 2.3e-35%3B 41.502%25 identity in 253 aa overlap and to SW:COBM_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-4 C11-methyltransferase (EC 2.1.1.133) CobM%2C 253 aa%3B fasta scores: opt: 652 Z-score: 746.5 bits: 145.8 E(): 5.5e-34%3B 43.145%25 identity in 248 aa overlap . Contains Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases gene gene1855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1855 SCO1856 SCO1856 SCI39.03 SCI39.03 1988469 1989701 + precorrin-6Y C5%2C15-methyltransferase SCI39.03%2C probable precorrin-6Y C5%2C15-methyltransferase%2C len: 410 aa%3B similar to SW:COBL_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-6Y C5%2C15-methyltransferase [decarboxylating] (EC 2.1.1.132) CobL%2C 413 aa%3B fasta scores: opt: 614 Z-score: 634.0 bits: 126.3 E(): 1e-27%3B 37.500%25 identity in 408 aa overlap. Contains Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases gene gene1856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1856 SCO1857 SCO1857 SCI39.04 SCI39.04 1989779 1991530 + bifunctional CbiGH SCI39.04%2C probable bifunctional protein (CbiGH)%2C len: 583 aa%3B N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein%2C 351 aa%3B fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09%3B 32.986%25 identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH%2C 241 aa%3B fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29%3B 46.862%25 identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG%2C CbiG and PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00639 Eukaryotic thiol (cysteine) proteases histidine active site gene gene1857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1857 SCO1858 SCO1858 SCI39.05 SCI39.05 1991527 1992444 + hypothetical protein SCI39.05%2C conserved hypothetical protein%2C len: 305 aa%3B similar to TR:O87690 (EMBL:AJ000758) Bacillus megaterium Cbi protein CbiX%2C 306 aa%3B fasta scores: opt: 791 Z-score: 870.2 bits: 169.1 E(): 7e-41%3B 39.000%25 identity in 300 aa overlap. Contains Pfam match to entry PF01903 CbiX%2C CbiX gene gene1858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1858 SCO1859 SCO1859 SCI39.06 SCI39.06 1992485 1993504 + hypothetical protein SCI39.06%2C probable aminotransferase%2C len: 339 aa%3B similar to SW:HIS8_ECOLI (EMBL:X03416) Escherichia coli histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC%2C 356 aa%3B fasta scores: opt: 351 Z-score: 375.7 bits: 78.0 E(): 2.4e-13%3B 29.450%25 identity in 309 aa overlap. Contains Pfam match to entry PF00222 aminotran_2%2C Aminotransferase class-II and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site gene gene1859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1859 SCO1860 SCO1860 SCI39.07c SCI39.07c 1994050 1995057 - hypothetical protein SCI39.07c%2C hypothetical protein%2C len: 335 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and possible N-terminal region signal peptide sequence and a possible hydrophobic membrane spanning region at the C-terminal domain gene gene1860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1860 SCO1861 SCO1861 SCI39.08c SCI39.08c 1995204 1996295 - hypothetical protein SCI39.08c%2C conserved hypothetical protein%2C len: 363 aa%3B similar to SW:YT15_MYCTU (EMBL:Z74697) Mycobacterium tuberculosis hypothetical 39.8 kDa protein RV2915c%2C 370 aa%3B fasta scores: opt: 1341 Z-score: 1487.0 bits: 283.8 E(): 3.1e-75%3B 56.630%25 identity in 362 aa overlap gene gene1861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1861 SCO1862 SCO1862 SCI39.09c SCI39.09c 1996351 1996833 - hypothetical protein SCI39.09c%2C possible integral membrane protein%2C len: 160 aa. Contains possible hydrophobic membrane spanning regions gene gene1862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1862 SCO1863 SCO1863 SCI39.10c SCI39.10c 1996945 1998165 - hypothetical protein SCI39.10c%2C unknown%2C len: 406 aa. High content in arginine amino acid residues and also highly hydrophilic gene gene1863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1863 SCO1864 SCO1864 SCI39.11 SCI39.11 1998468 1998980 + acetyltransferase SCI39.11%2C probable acetyltransferase%2C len: 170 aa%3B similar to SW:ECTA_MARHA (EMBL:U66614) Marinococcus halophilus L-2%2C4-diaminobutyric acid acetyltransferase (EC 2.3.1.*) EctA%2C 172 aa%3B fasta scores: opt: 443 Z-score: 540.9 bits: 106.5 E(): 1.5e-22%3B 42.675%25 identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1864 SCO1865 SCO1865 SCI39.12 SCI39.12 1999110 2000381 + diaminobutyrate--2-oxoglutarate aminotransferase catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde gene gene1865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1865 SCO1866 SCO1866 ectC ectC 2000500 2000898 + L-ectoine synthase N-acetyldiaminobutyrate dehydratase%3B catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha%2Cgamma-diaminobutyric acid gene gene1866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1866 SCO1867 SCO1867 SCI39.14 SCI39.14 2000962 2001804 + hydroxylase SCI39.14%2C possible hydroxylase%2C len: 280 aa%3B similar to TR:O06499 (EMBL:D78338) Dactylosporangium L-proline 4-hydroxylase%2C 272 aa%3B fasta scores: opt: 458 Z-score: 529.1 bits: 105.7 E(): 7.1e-22%3B 34.351%25 identity in 262 aa overlap gene gene1867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1867 SCO1868 SCO1868 SCI39.15c SCI39.15c 2001886 2002980 - hypothetical protein SCI39.15c%2C conserved hypothetical protein%2C len: 364 aa%3B similar to SW:YCBU_BACSU (EMBL:AB000617) Bacillus subtilis hypothetical protein homologue of class-V proteins of pyridoxal-phosphate-dependent aminotransferase YcbU%2C aa%3B fasta scores: opt: 277 Z-score: 303.9 bits: 64.9 E(): 2.5e-09%3B 27.707%25 identity in 314 aa overlap gene gene1868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1868 SCO1869 SCO1869 SCI39.16c SCI39.16c 2003040 2003753 - hypothetical protein SCI39.16c%2C conserved hypothetical protein%2C len: 237 aa%3B similar to TR:O68911 (EMBL:AF058302) Streptomyces roseofulvus FrnE protein%2C 216 aa%3B fasta scores: opt: 528 Z-score: 605.5 bits: 119.3 E(): 3.9e-26%3B 46.919%25 identity in 211 aa overlap and to TR:Q9ZA40 (EMBL:AJ011500) Streptomyces violaceoruber disulphide bond-forming protein Gra-ORF19%2C 220 aa%3B fasta scores: opt: 316 Z-score: 366.6 bits: 75.1 E(): 7.9e-13%3B 37.104%25 identity in 221 aa overlap gene gene1869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1869 SCO1870 SCO1870 SCI39.17c SCI39.17c 2003846 2004454 - hypothetical protein SCI39.17c%2C unknown%2C len: 202 aa gene gene1870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1870 SCO1871 SCO1871 SCI39.18c SCI39.18c 2004598 2006127 - aldehyde dehydrogenase SCI39.18c%2C probable aldehyde dehydrogenase%2C len: 509 aa%3B similar to TR:Q56694 (EMBL:U39638) Vibrio harveyi fatty aldehyde dehydrogenase AldH%2C 510 aa%3B fasta scores: opt: 1209 Z-score: 1264.1 bits: 243.5 E(): 8e-63%3B 42.300%25 identity in 487 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family gene gene1871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1871 SCO1872 SCO1872 SCI39.19 SCI39.19 2006250 2007023 + IclR family transcriptional regulator SCI39.19%2C probable IclR-family transcriptional regulator%2C len: 257 aa%3B similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR%2C 274 aa%3B fasta scores: opt: 413 Z-score: 491.6 bits: 98.6 E(): 8.7e-20%3B31.855%25 identity in 248 aa overlap and to TR:Q9RDE7 (EMBL:AL136503) Streptomyces coelicolor IclR-family transcriptional regulator SCC77.11%2C 265aa%3B fasta scores: opt: 766 Z-score: 904.5 bits: 175.0 E(): 8.6e-43%3B 52.846%25 identity in 246 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator and possible helix-turn-helix motif at residues 32..53 (+3.00 SD) gene gene1872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1872 SCO1873 SCO1873 SCI39.20 SCI39.20 2007027 2007497 + acetyltransferase SCI39.20%2C probable acetyltransferase%2C len: 156 aa%3B similar to TR:Q9SKZ7 (EMBL:AC006223) Arabidopsis thaliana alanine acetyl transferase AT2G32020%2C 183 aa%3B fasta scores: opt: 205 Z-score: 253.5 bits: 53.3 E(): 1.6e-06%3B 31.210%25 identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene1873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1873 SCO1874 SCO1874 SCI39.21 SCI39.21 2007606 2007818 + hypothetical protein SCI39.21%2C hypothetical protein%2C len: 70 aa%3B similar to C-terminal region of many two-component system response regulators%2C e.g. TR:Q9K3I0 (EMBL:AL390188) Streptomyces coelicolor two-component system response regulator 2SCG18.07%2C 220 aa%3B fasta scores: opt: 154 Z-score: 195.9 bits: 41.7 E(): 0.0025%3B 54.717%25 identity in 53 aa overlap gene gene1874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1874 SCO1875 SCO1875 SCI39.22 SCI39.22 2007938 2009392 + penicillin binding protein SCI39.22%2C possible penicillin-binding protein%2C len: 484 aa%3B similar to TR:Q9L656 (EMBL:AF241575) Streptomyces griseus PbpA%2C 485 aa%3B fasta scores: opt: 1581 Z-score: 1674.1 bits: 319.2 E(): 1.2e-85%3B 51.633%25 identity in 490 aa overlap and to TR:Q9XA17 (EMBL:AL079308) Streptomyces coelicolor penicillin binding protein SCH69.17%2C 490 aa%3B fasta scores: opt: 1649 Z-score: 1745.9 bits: 332.5 E(): 1.2e-89%3B 52.965%25 identity in 489 aa overlap. Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains N-terminal region signal peptide sequence gene gene1875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1875 SCO1876 SCO1876 SCI39.23 SCI39.23 2009469 2010041 + RNA polymerase sigma factor SCI39.23%2C possible RNA polymerase sigma factor%2C len: 190 aa%3B similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE%2C 176 aa%3B fasta scores: opt: 210 Z-score: 262.1 bits: 55.1 E(): 5.2e-07%3B 34.177%25 identity in 158 aa overlap. Contains possible helix-turn-helix motif at residues 132..153 (+3.59 SD) gene gene1876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1876 SCO1877 SCO1877 SCI39.24 SCI39.24 2010038 2010712 + hypothetical protein SCI39.24%2C unknown%2C len: 224 aa gene gene1877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1877 SCO1878 SCO1878 SCI39.25c SCI39.25c 2010725 2011522 - hypothetical protein SCI39.25c%2C possible hypothetical protein%2C len: 265 aa. Contains possible N-terminal region signal peptide sequence gene gene1878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1878 SCO1879 SCO1879 SCI39.26c SCI39.26c 2011647 2012792 - pectinesterase SCI39.26c%2C probable pectinesterase%2C len: 381 aa%3B similar to SW:PME_BURSO (EMBL:M62803) Burkholderia solanacearum pectinesterase precursor (EC 3.1.1.11) Pme%2C 396 aa%3B fasta scores: opt: 350 Z-score: 372.6 bits: 77.7 E(): 3.7e-13%3B 32.036%25 identity in 334 aa overlap. Contains Pfam match to entry PF01095 Pectinesterase%2C Pectinesterase and match to Prosite entry PS00503 Pectinesterase signature 2. Contains also possible N-terminal region signal peptide sequence gene gene1879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1879 SCO1880 SCO1880 SCI39.27c SCI39.27c 2012859 2014193 - pectate lyase SCI39.27c%2C probable pectate lyase%2C len: 444 aa%3B similar to SW:PEL_BACS (EMBL:X74880) Bacillus subtilis pectate lyase precursor (EC 4.2.2.2) Pel%2C 420 aa%3B fasta scores: opt: 1127 Z-score: 1249.8 bits: 240.3 E(): 5e-62%3B 42.431%25 identity in 436 aa overlap. Contains 2x Pfam matches to entry PF00544 pec_lyase%2C Pectate lyase. Contains also possible N-terminal region signal peptide sequence gene gene1880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1880 SCO1881 SCO1881 SCI39.28c SCI39.28c 2014258 2015061 - hypothetical protein SCI39.28c%2C hypothetical protein%2C len: 267 aa%3B similar to TR:O31528 (EMBL:Z99107) Bacillus subtilis YesY protein%2C 217 aa%3B fasta scores: opt: 548 Z-score: 648.8 bits: 127.5 E(): 1.5e-28%3B 43.939%25 identity in 198 aa overlap and to TR:Q9L936 (EMBL:AF184175) Bacillus sp. KCCM10143 cephalosporin C deacetylase 217 aa%3B fasta scores: opt: 544 Z-score: 644.2 bits: 126.6 E(): 2.7e-28%3B 44.500%25 identity in 200 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene1881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1881 SCO1882 SCO1882 SCI39.29c SCI39.29c 2015194 2016552 - sugar-binding protein SCI39.29c%2C probable sugar-binding protein%2C len: 452 aa%3B similar to TR:P72397 (EMBL:Y07706) Streptomyces coelicolor maltose-binding protein MalE%2C 423 aa%3B fasta scores: opt: 433 Z-score: 459.6 bits: 94.2 E(): 5.2e-18%3B 30.716%25 identity in 433 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and possible N-terminal region signal peptide sequence gene gene1882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1882 SCO1883 SCO1883 SCI39.30c SCI39.30c 2016628 2018172 - xylanase SCI7.01c%2C partial CDS%2C possible xylanase%2C len: >95aa%3B similar to the N-terminal region of many eg. TR:O30426 (EMBL:AF005383) xylanase from the thermophile Caldocellum saccharolyticum (1347 aa) fasta scores%3B opt: 263%2C z-score: 357.5%2C E(): 1.4e-12%2C (35.2%25 identity in 91 aa overlap).~SCI39.30c%2C probable xylanase (fragment)%2C len: >458 aa%3B similar to TR:Q9WXE8 (EMBL:AB022865) Prevotella ruminicola xylosidase%2C 452 aa%3B fasta scores: opt: 553 Z-score: 572.6 bits: 115.2 E(): 2.6e-24%3B 37.954%25 identity in 303 aa overlap gene gene1883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1883 SCO1884 SCO1884 SCI7.02c SCI7.02c 2018169 2019014 - hypothetical protein SCI7.02c%2C unknown%2C len: 281aa gene gene1884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1884 SCO1885 SCO1885 SCI7.03c SCI7.03c 2019011 2020168 - oxidoreductase SCI7.03c%2C possible oxidoreductase%2C len: 385 aa%3B similar to many proteins of undefined function eg. TR:Q45376 (EMBL:X90711) from a locus required for lipopolysaccharide biosynthesis in Bordetella pertussis (350 aa) fasta scores%3B opt: 232%2C z-score: 266.7%2C E(): 1.6e-07%2C (28.0%25 identity in 275 aa overlap). Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene1885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1885 SCO1886 SCO1886 SCI7.04c SCI7.04c 2020165 2021061 - integral membrane transport protein SCI7.04c%2C possible integral membrane transport protein%2C len: 298aa%3B similar to many eg. SW:YURM_BACSU hypothetical ABC transporter from Bacillus subtilis (300 aa) fasta scores%3B opt: 582%2C z-score: 650.2%2C E(): 6.9e-29%2C (31.7%25 identity in 293 aa overlap) and TR:O87858 (EMBL:AL031013) transmembrane sugar transport protein from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 540%2C z-score: 604.3%2C E(): 2.5e-26%2C (34.7%25 identity in 277 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible membrane spanning hydrophobic regions. gene gene1886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1886 SCO1887 SCO1887 SCI7.05c SCI7.05c 2021058 2021993 - integral membrane transport protein SCI7.05c%2C possible integral membrane transport protein%2C len: 298aa%3B similar to many eg. TR:O51924 (EMBL:AF012836) inner membrane protein%2C MalF from the trehalose/maltose transport system of the hyperthermophilic archaeon Thermococcus litoralis (300 aa) fasta scores%3B opt: 681%2C z-score: 814.3%2C E(): 0%2C (37.5%25 identity in 285 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible membrane spanning hydrophobic regions. gene gene1887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1887 SCO1888 SCO1888 SCI7.06c SCI7.06c 2022115 2023845 - dihydroxy-acid dehydratase catalyzes the formation of 3-methyl-2-oxobutanoate from 2%2C3%2C-dihydroxy-3-methylbutanoate gene gene1888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1888 SCO1889 SCO1889 SCI7.07c SCI7.07c 2023842 2024750 - dihydropicolinate synthase SCI7.07c%2C probable dihydropicolinate synthase%2C len: 302 aa%3B similar to many e.g. SW:DAPA_BACSU dihydropicolinate synthase from Bacillus subtilis (290 aa) fasta scores%3B opt: 280%2C z-score: 323.5%2C E(): 1.1e-10%2C (28.2%25 identity in 284 aa overlap). Contains Pfam match to entry PF00701 DHDPS%2C Dihydrodipicolinate synthetase family. gene gene1889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1889 SCO1890 SCO1890 SCI7.08c SCI7.08c 2024747 2025415 - transcriptional regulator SCI7.08c%2C probable transcriptional regulator%2C len: 177aa%3B similar to many egs. TR:O50514 (EMBL:AL009204) transcriptional regulator from Streptomyces coelicolor (231 aa) fasta scores%3B opt: 272%2C z-score: 328.8%2C E(): 5.6e-11%2C 934.4%25 identity in 224 aa overlap) and SW:GNTR_BACSU transcriptional regulator of the gluconate operon of Bacillus subtilis (243 aa) fasta scores%3B opt: 217%2C z-score: 264.1%2C E(): 2.2e-07%2C (33.1%25 identity in 127 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. Also contains a helix-turn-helix motif (+3.07 SD) 35-56aa. gene gene1890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1890 SCO1891 SCO1891 SCI7.09c SCI7.09c 2025584 2026183 - hypothetical protein SCI7.09c%2C hypothetical protein%2C len: 199 aa%3B similar to TR:P71985 (EMBL:Z81360) hypothetical protein from Mycobacterium tuberculosis (189 aa) fasta scores%3B opt: 210%2C z-score: 248.3%2C E(): 1.7e-06%2C (32.4%25 identity in 182 aa overlap). gene gene1891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1891 SCO1892 SCO1892 SCI7.10 SCI7.10 2026325 2027572 + integral membrane efflux protein SCI7.10%2C possible integral membrane efflux protein%2C len: 415aa%3B similar to many egs. TR:CAB41206 (EMBL:AL049661) integral membrane efflux protein from Streptomyces coelicolor (500 aa) fasta scores%3B opt: 347%2C z-score: 354.0%2C E(): 2.2e-12%2C (29.7%25 identity in 408 aa overlap) and SW:TCR3_ECOLI tetracycline resistance protein from Escherichia coli (396 aa) fasta scores%3B opt: 241%2C z-score: 249.6%2C E(): 1.4e-06%2C (25.9%25 identity in 398 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene1892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1892 SCO1893 SCO1893 SCI7.11c SCI7.11c 2027561 2027953 - lyase SCI7.11c%2C possible lyase%2C len: 130aa%3B similar to many egs. TR:O86701 (EMBL:AL031515) lyase from Streptomyces coelicolor (138 aa) fasta scores%3B opt: 153%2C z-score: 201.1%2C E(): 0.00072%2C (30.5%25 identity in 131 aa overlap) and SW:LGUL_ECOLI lactolylglutathione lyase from Escherichia coli (135 aa) fasta scores%3B opt: 111%2C z-score: 150.2%2C E(): 0.49%2C (28.3%25 identity in 138 aa overlap). gene gene1893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1893 SCO1894 SCO1894 SCI7.12c SCI7.12c 2028038 2029210 - hypothetical protein SCI7.12c%2C alanine-rich protein%2C len: 390aa gene gene1894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1894 SCO1895 SCO1895 SCI7.13c SCI7.13c 2029207 2030157 - 5-dehydro-4-deoxyglucarate dehydratase catalyzes the formation of 2%2C5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate gene gene1895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1895 SCO1896 SCO1896 SCI7.14 SCI7.14 2030392 2031201 + hypothetical protein SCI7.14%2C unknown%2C len: 269aa%3B similar to many eg. SW:YTBQ_BACSU hypothetical protein from Bacillus subtilis (253 aa) fasta scores%3B opt: 262%2C z-score: 310.1%2C E(): 6.1e-10%2C (27.8%25 identity in 241 aa overlap). gene gene1896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1896 SCO1897 SCO1897 SCI7.15 SCI7.15 2031485 2032261 + transcriptional regulator SCI7.15%2C probable transcriptional regulator%2C len: 258 aa%3B similar to many e.g. SW:GATR_ECOLI galacticol utilisation operon repressor from Escherichia coli (259 aa) fasta scores%3B opt: 399%2C z-score: 477.4%2C E(): 2.9e-19%2C (33.8%25 identity in 237 aa overlap). Contains Pfam match to entry PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family. Also contains a helix-turn-helix motif (+3.53 SD) 26-47aa. gene gene1897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1897 SCO1898 SCO1898 SCI7.16 SCI7.16 2032364 2033734 + substrate binding protein SCI7.16%2C possible sugar binding protein%2C len: 456aa%3B similar to many eg. TR:O30831 (EMBL:AF018073) periplasmic sorbitol binding protein from Rhodobacter sphaeroides (436 aa) fasta scores%3B opt: 1203%2C z-score: 1347.3%2C E(): 0%2C (42.8%25 identity in 423 aa overlap). Contains possible N-terminal signal sequence. gene gene1898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1898 SCO1899 SCO1899 SCI7.17 SCI7.17 2033731 2034675 + integral membrane sugar transport protein SCI7.17%2C possible integral membrane sugar transport protein%2C len: 314aa%3B similar to many eg. TR:O30832 (EMBL:AF018073) sorbitol/mannitol transport inner membrane protein from Rhodobacter sphaeroides (290 aa) fasta scores%3B opt: 722%2C z-score: 829.0%2C E(): 0%2C (40.6%25 identity in 276 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible membrane spanning hydrophobic regions. gene gene1899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1899 SCO1900 SCO1900 SCI7.18 SCI7.18 2034672 2035550 + integral membrane sugar transport protein SCI7.18%2C possible integral membrane sugar transport protein%2C len: 292aa%3B similar to many eg. TR:O30833 (EMBL:AF018073) sorbitol/mannitol transport inner membrane protein from Rhodobacter sphaeroides (276 aa) fasta scores%3B opt: 659%2C z-score: 770.4%2C E(): 0%2C (40.6%25 identity in 276 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains possible membrane spanning hydrophobic regions. gene gene1900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1900 SCO1901 SCO1901 SCI7.19 SCI7.19 2035547 2036536 + zinc-binding dehydrogenase SCI7.19%2C probable zinc-binding dehydrogenase%2C len: 329 aa%3B similar to many e.g. SW:DHSO_BACSU sorbitol dehydrogenase from Bacillus subtilis (352 aa) fasta scores%3B opt: 552%2C z-score: 626.6%2C E(): 1.4e-27%2C (30.1%25 identity in 345 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and Prosite match to PS00059 Zinc-containing alcohol dehydrogenases signature gene gene1901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1901 SCO1902 SCO1902 SCI7.20 SCI7.20 2036555 2036944 + hypothetical protein SCI7.20%2C unknown%2C hydrophilic%2C len: 129aa gene gene1902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1902 SCO1903 SCO1903 SCI7.21 SCI7.21 2037030 2038229 + transport associated protein SCI7.21%2C possible transport associated protein%2C len: 399aa%3B appears to be the last gene in a possible sugar transport operon%2C similar to many eg. TR:CAB38155 (EMBL:AL035591) export associated protein from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 475%2C z-score: 388.5%2C E(): 2.6e-14%2C (43.6%25 identity in 188 aa overlap) and TR:CAA22211 (EMBL:AL034355) hypothetical protein from Streptomyces coelicolor (482 aa) fasta scores%3B opt: 534%2C z-score: 428.9%2C E(): 1.5e-16%2C (42.3%25 identity in 260 aa overlap) and SW:TERZ_SERMA tellurium resistance protein%2C TerZ from Serratia marcescens (193 aa) fasta scores%3B opt: 429%2C z-score: 352.8%2C E(): 2.6e-12%2C (47.6%25 identity in 185 aa overlap). gene gene1903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1903 SCO1904 SCO1904 SCI7.22c SCI7.22c 2038269 2038877 - transcriptional regulator SCI7.22c%2C probable transcriptional regulator%2C len: 202 aa%3B similar to many e.g. TR:CAA22690 (EMBL:AL035159) transcriptional regulator from Mycobacterium leprae (189 aa) fasta scores%3B opt: 353%2C z-score: 418.1%2C E(): 5.9e-16%2C (38.6%25 identity in 189 aa overlap) and TR:O24739 (EMBL:AB001609) butyrolactone synthesis transcriptional regulator in Streptomyces virginiae (216 aa) fasta scores%3B opt: 191%2C z-score: 231.1%2C E(): 1.5e-05%2C (35.0%25 identity in 163 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains a helix-turn-helix motif (+5.38 SD) 46-67aa. gene gene1904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1904 SCO1905 SCO1905 SCI7.23c SCI7.23c 2038879 2040480 - hypothetical protein SCI7.23c%2C unknown%2C len: 533aa gene gene1905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1905 SCO1906 SCO1906 SCI7.24c SCI7.24c 2040979 2042451 - hypothetical protein SCI7.24c%2C hypothetical protein%2C len: 490 aa%3B similar to TR:O69840 (EMBL:AL023517) hypothetical protein from Streptomyces coelicolor (465 aa) fasta scores%3B opt: 1059%2C z-score: 1178.4%2C E(): 0%2C (48.1%25 identity in 495 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene1906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1906 SCO1907 SCO1907 SCI7.25c SCI7.25c 2042736 2044163 - hypothetical protein SCI7.25c%2C unknown%2C len: 475aa%3B contains Prosite match to PS00213 Lipocalin signature. Similar to TR:Q9RJ26 (EMBL:AL132644) SCI8.27C hypothetical protein from Streptomyces coelicolor (447 aa) fasta scores%3B opt: 380%2C Z-score: 401.6%2C E(): 9.7e-15%2C 32.114%25 identity (38.257%25 ungapped) in 492 aa overlap. gene gene1907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1907 SCO1908 SCO1908 SCI7.26 SCI7.26 2044380 2046221 + large hypothetical protein SCI7.26%2C possible large hypothetical protein%2C len: 613aa%3B similar to TR:O83555 (EMBL:AE001229) hypothetical protein from Treponema pallidum (622 aa) fasta scores%3B opt: 478%2C z-score: 514.7%2C E(): 2.4e-21%2C (34.0%25 identity in 633 aa overlap). Contains possible N-terminal signal sequence. gene gene1908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1908 SCO1909 SCO1909 SCI7.27c SCI7.27c 2046252 2046959 - hypothetical protein SCI7.27c%2C unknown%2C len: 235aa gene gene1909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1909 SCO1910 SCO1910 SCI7.28c SCI7.28c 2047117 2047614 - alanine-rich protein SCI7.28c%2C possible alanine-rich protein%2C len: 165 aa%3B contains 3 x H**H*KAGRA* repeat region. Largely hydrophilic. Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene1910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1910 SCO1911 SCO1911 SCI7.29c SCI7.29c 2047611 2048108 - hypothetical protein SCI7.29c%2C possible integral membrane protein%2C len: 165aa%3B similar to others from Mycobacterium tuberculosis and Streptomyces coelicolor egs. TR:O69637 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (172 aa) fasta scores%3B opt: 194%2C z-score: 223.8%2C E(): 3.9e-05%2C (30.6%25 identity in 134 aa overlap) and SW:CAA22031 (EMBL:AL033505) membrane protein from Streptomyces coelicolor (205 aa) fasta scores%3B opt: 187%2C z-score: 215.2%2C E(): 0.00012%2C (33.8%25 identity in 130 aa overlap). Contains possible membrane spanning hydrophobic region. Also contains a helix-turn-helix motif (+3.21 SD) 39-60aa. gene gene1911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1911 SCO1912 SCO1912 SCI7.30 SCI7.30 2048176 2049129 + 4-hydroxy-tetrahydrodipicolinate synthase catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis gene gene1912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1912 SCO1913 SCO1913 SCI7.31c SCI7.31c 2049114 2049380 - small membrane protein SCI7.31c%2C possible small membrane protein%2C len: 88 aa%3B contains possible hydrophobic membrane spanning region gene gene1913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1913 SCO1914 SCO1914 SCI7.32 SCI7.32 2049519 2049689 + hypothetical protein SCI7.32%2C unknown%2C len: 56aa gene gene1914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1914 SCO1915 SCO1915 SCI7.33 SCI7.33 2049745 2050473 + hypothetical protein SCI7.33%2C unknown%2C len: 242aa gene gene1915 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1915 SCO1916 SCO1916 SCI7.34c SCI7.34c 2050524 2051513 - 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase SCI7.34c%2C possible transferase%2C len: 329 aa%3B similar to many e.g. TR:BAA75911 (EMBL:AB024601) tetrahydrodipicolinate N-succinyltransferase from Pseudomonas aeruginosa (344 aa) fasta scores%3B opt: 1004%2C z-score: 1062.7%2C E(): 0%2C (54.4%25 identity in 307 aa overlap). Contains possible N-terminal signal sequence. gene gene1916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1916 SCO1917 SCO1917 SCI7.35c SCI7.35c 2051523 2052116 - hypothetical protein SCI7.35c%2C unknown%2C len: 197aa%3B similar to many eg. TR:P95092 (EMBL:Z83866) hypothetical protein from Mycobacterium tuberculosis (202 aa) fasta scores%3B opt: 398%2C z-score: 482.3%2C E(): 1.6e-19%2C (40.3%25 identity in 191 aa overlap). gene gene1917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1917 SCO1918 SCO1918 SCI7.36c SCI7.36c 2052116 2052436 - hypothetical protein SCI7.36c%2C possible integral membrane protein%2C len: 106aa%3B similar to many proposed to be involved in resistance mechanisms eg. SW:EMRE_ECOLI viologen resistance protein from Escherichia coli (110 aa) fasta scores%3B opt: 313%2C z-score: 392.7%2C E(): 1.5e-14%2C (51.0%25 identity in 100 aa overlap). Contains Pfam match to entry PF00893 DUF7%2C Integral membrane protein. gene gene1918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1918 SCO1919 SCO1919 SCC22.01c SCC22.01c 2052555 2052887 - hypothetical protein SCC22.01c%2C partial CDS%2C conserved hypothetical protein%2C len: >75aa%3B similar to many other hypothetical proteins eg. TR:O53157 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (115 aa) fasta scores%3B opt: 284%2C z-score: 392.0%2C E(): 1.7e-14%2C (61.3%25 identity in 80 aa overlap).~SCI7.37c%2C partial CDS%2C unknown%2C len: >74aa%3B similar to TR:O53157 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (115 aa) fasta scores%3B opt: 375%2C z-score: 536.1%2C E(): 1.6e-22%2C (70.1%25 identity in 77 aa overlap). gene gene1919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1919 SCO1920 SCO1920 SCC22.02c SCC22.02c 2052884 2053354 - hypothetical protein SCC22.02c%2C conserved hypothetical protein%2C len: 156aa%3B similar to many other hypothetical protein eg. TR:O53156 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores%3B opt: 569%2C z-score: 685.8%2C E(): 7.2e-31%2C (56.3%25 identity in 158 aa overlap) and to SW:NIFU_BACSU (EMBL:Z99120) Bacillus subtilis NifU-like protein NifU%2C 147 aa%3B fasta scores: opt: 439 Z-score: 527.7 E(): 9.3e-22%3B 45.517%25 identity in 145 aa overlap gene gene1920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1920 SCO1921 SCO1921 SCC22.03c SCC22.03c 2053372 2054628 - aminotransferase SCC22.03c%2C possible aminotransferase%2C len: 418 aa%3B similar to many proposed aminotransferase/nifS-like proteins e.g. TR:Q49690 (EMBL:U00013) NifS from Mycobacterium leprae (418 aa) fasta scores%3B opt: 1438%2C z-score: 1673.0%2C E(): 0%2C (53.4%25 identity in 414 aa overlap). Contains Pfam match to entry PF00266 aminotran_5%2C Aminotransferases class-V. gene gene1921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1921 SCO1922 SCO1922 SCC22.04c SCC22.04c 2054625 2055389 - ABC transporter ATP-binding protein SCC22.04c%2C possible ABC transporter ATP-binding subunit%2C len: 254aa%3B similar to many proposed ABC transporter subunit eg. SW:ABCX_CYAPA probable ATP-dependent transporter from Cyanophora paradoxa (259 aa) fasta scores%3B opt: 856%2C z-score: 945.3%2C E(): 0%2C (55.3%25 identity in 246 aa overlap). Also highly similar to TR:O53154 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (266 aa) fasta scores%3B opt: 1258%2C z-score: 1383.7%2C E(): 0%2C (76.9%25 identity in 251 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene1922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1922 SCO1923 SCO1923 SCC22.05c SCC22.05c 2055397 2055714 - dioxygenase ferredoxin subunit SCC22.05c%2C possible dioxygenase ferredoxin subunit%2C len: 105 aa%3B similar to many e.g. SW:BEDB_PSEPU benzene dioxygenase from Pseudomonas putida ML2 (107 aa) fasta scores%3B opt: 286%2C z-score: 390.9%2C E(): 1.9e-14%2C (40.6%25 identity in 101 aa overlap) gene gene1923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1923 SCO1924 SCO1924 SCC22.06c SCC22.06c 2055711 2056895 - hypothetical protein SCC22.06c%2C conserved hypothetical protein%2C len: 394aa%3B similar to many eg. TR:O53153 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (397 aa) fasta scores%3B opt: 1446%2C z-score: 1649.9%2C E(): 0%2C (58.0%25 identity in 388 aa overlap). Contains Pfam match to entry PF01458 UPF0051%2C Uncharacterized protein family (UPF0051). gene gene1924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1924 SCO1925 SCO1925 SCC22.07c SCC22.07c 2056956 2058377 - hypothetical protein SCC22.07c%2C conserved hypothetical protein%2C len: 473aa%3B similar to many eg. TR:O32162 (EMBL:Z99120) hypothetical protein from Bacillus subtilis (465 aa) fasta scores%3B opt: 2087%2C z-score: 2451.5%2C E(): 0%2C (64.6%25 identity in 463 aa overlap). Also similar to the N-terminal region and the C-terminal region of TR:O53152 (EMBL:AL021184) hypothetical splice protein from Mycobacterium tuberculosis (846 aa) fasta scores%3B opt: 1367%2C z-score: 1602.5%2C E(): 0%2C (47.5%25 identity in 832 aa overlap). Contains Pfam match to entry PF01458 UPF0051%2C Uncharacterized protein family (UPF0051). gene gene1925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1925 SCO1926 SCO1926 SCC22.08c SCC22.08c 2058374 2059132 - DNA-binding protein SCC22.08c%2C possible DNA-binding protein%2C len: 252aa%3B similar to TR:O53151 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (278 aa) fasta scores%3B opt: 629%2C z-score: 705.6%2C E(): 5.8e-32%2C (46.8%25 identity in 233 aa overlap). Contains a helix-turn-helix motif (+4.75 SD) at residues 34-55 gene gene1926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1926 SCO1927 SCO1927 SCC22.09 SCC22.09 2059304 2060092 + AAC(3) family N-acetyltransferase SCC22.09%2C possible aminoglycoside acetyltransferase%2C len: 262 aa%3B similar to many e.g. SW:AAC8_STRFR aminoglycoside acetyltransferase from Streptomyces fradiae (286 aa) fasta scores%3B opt: 502%2C z-score: 576.5%2C E(): 8.9e-25%2C (40.4%25 identity in 270 aa overlap) gene gene1927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1927 SCO1928 SCO1928 SCC22.10 SCC22.10 2060169 2061092 + ABC transporter ATP-binding protein SCC22.10%2C possible ABC transporter%2C ATP-binding subunit%2C len: 307aa%3B similar to many egs. SW:DRRA_STRPE daunorubicin resistance ATP-binding protein from Streptomyces peucetius (330 aa) fasta scores%3B opt: 571%2C z-score: 637.1%2C E(): 3.7e-28%2C (35.6%25 identity in 315 aa overlap) and TR:O53149 (EMBL:AL021184) ABC transporter%2C ATP-binding protein from Mycobacterium tuberculosis (313 aa) fasta scores%3B opt: 1170%2C z-score: 1297.6%2C E(): 0%2C (60.9%25 identity in 304 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. gene gene1928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1928 SCO1929 SCO1929 SCC22.11 SCC22.11 2061089 2061898 + integral membrane transport protein SCC22.11%2C possible integral membrane transport protein%2C len: 269aa%3B function predicted as it contains possible membrane spanning hydrophobic regions and is located alongside a possible ABC transport ATP-binding protein (SCC22.10). Similar to egs. TR:O86349 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (261 aa) fasta scores%3B opt: 627%2C z-score: 670.8%2C E(): 4.9e-30%2C (43.6%25 identity in 264 aa overlap) and TR:AAD20380 (EMBL:AF125999) daunorubicin resistance protei n C from Mycobacterium avium (263 aa) fasta scores%3B opt: 266%2C z-score: 291.2%2C E(): 7e-09%2C (29.6%25 identity in 247 aa overlap). gene gene1929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1929 SCO1930 SCO1930 SCC22.12 SCC22.12 2061905 2062975 + integral membrane transport protein SCC22.12%2C possible integral membrane transport protein%2C len: 356aa%3B function predicted as it contains possible membrane spanning hydrophobic regions and is located alongside a possible ABC transport ATP-binding protein (SCC22.10). Similar to TR:O53148 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (310 aa) fasta scores%3B opt: 527%2C z-score: 648.1%2C E(): 9.2e-29%2C (35.0%25 identity in 300 aa overlap). gene gene1930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1930 SCO1931 SCO1931 SCC22.13c SCC22.13c 2062930 2063709 - hypothetical protein SCC22.13c%2C unknown%2C len: 259aa gene gene1931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1931 SCO1932 SCO1932 SCC22.14c SCC22.14c 2063713 2064819 - hypothetical protein SCC22.14c%2C unknown%2C len: 368aa%3B similar to TR:O07751 (EMBL:Z97193) hypothetical protein from Mycobacterium tuberculosis (378 aa) fasta scores%3B opt: 772%2C z-score: 899.4%2C E(): 0%2C (40.3%25 identity in 372 aa overlap). gene gene1932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1932 SCO1933 SCO1933 SCC22.15c SCC22.15c 2064934 2065368 - hypothetical protein SCC22.15c%2C unknown%2C len: 144aa gene gene1933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1933 SCO1934 SCO1934 SCC22.16c SCC22.16c 2065389 2066411 - protoheme IX farnesyltransferase converts protoheme IX and farnesyl diphosphate to heme O gene gene1934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1934 SCO1935 SCO1935 SCC22.17 SCC22.17 2066713 2068800 + transketolase catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate%3B can transfer ketol groups between several groups%3B in Escherichia coli there are two tkt genes%2C tktA expressed during exponential growth and the tktB during stationary phase gene gene1935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1935 SCO1936 SCO1936 SCC22.18 SCC22.18 2068835 2069953 + transaldolase catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate gene gene1936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1936 SCO1937 SCO1937 SCC22.19 SCC22.19 2069957 2071480 + glucose-6-phosphate 1-dehydrogenase catalyzes the formation of D-glucono-1%2C5-lactone 6-phosphate from D-glucose 6-phosphate gene gene1937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1937 SCO1938 SCO1938 SCC22.20 SCC22.20 2071477 2072532 + hypothetical protein SCC22.20%2C hypothetical protein%2C len: 351 aa%3B similar to TR:O88016 (EMBL:AL031107) hypothetical protein from Streptomyces coelicolor (311 aa) fasta scores%3B opt: 1363%2C z-score: 1605.9%2C E(): 0%2C (71.3%25 identity in 300 aa overlap) and TR:O06813 (EMBL:Z95844) hypothetical protein from Mycobacterium tuberculosis (303 aa) fasta scores%3B opt: 849%2C z-score: 1002.6%2C E(): 0%2C (46.3%25 identity in 309 aa overlap). gene gene1938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1938 SCO1939 SCO1939 SCC22.21 SCC22.21 2072529 2073314 + 6-phosphogluconolactonase catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1%2C5-lactone gene gene1939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1939 SCO1940 SCO1940 SCC22.22c SCC22.22c 2073377 2074144 - hypothetical protein SCC22.22c%2C possible hypothetical protein%2C len: 255 aa%3B weakly similar to hypothetical proteins e.g. TR:O33272 (EMBL:Z83018) hypothetical protein from Mycobacterium tuberculosis (255 aa) fasta scores%3B opt: 181%2C z-score: 213.5%2C E(): 0.00015%2C (27.0%25 identity in 226 aa overlap. Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence gene gene1940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1940 SCO1941 SCO1941 SCC22.23c SCC22.23c 2074235 2075203 - hypothetical protein SCC54.01c%2C partial CDS%2C possible intergral membrane protein%2C len: >183aa%3B contains possible membrane spanning hydrophobic regions.~SCC22.23c%2C partial CDS%2C possible integral membrane protein%2C len: >178aa%3B forms the C-terminal portion of TR:CAB38131 (EMBL:AL035591) partial CDS%2C possible integral membrane protein on the end of cosmid C54 from Streptomyces coelicolor. gene gene1941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1941 SCO1942 SCO1942 pgi pgi 2075313 2076968 - glucose-6-phosphate isomerase functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis%3B catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate%3B member of PGI family gene gene1942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1942 SCO1943 SCO1943 SCC54.03c SCC54.03c 2077084 2077419 - electron transport protein SCC54.03c%2C possible electron transport protein%2C len: 111 aa%3B similar to TR:O53492 (EMBL:AL021899) hypothetical protein from Mycobacterium tuberculosis (111 aa) fasta scores%3B opt: 204%2C z-score: 250.4%2C E(): 1.2e-06%2C (36.9%25 identity in 103 aa overlap). Contains PS00202 Rubredoxin signature. gene gene1943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1943 SCO1944 SCO1944 secG secG 2077633 2077941 - preprotein translocase subunit SecG SCC54.04c%2C secG%2C integral membrane protein%2C len: 102 aa%3B varying levels of similarity to many with similarity to SecG proteins e.g. TR:E1363411 (EMBL:AJ007732) SecG protein (undefined) from Corynebacterium glutamicum (77 aa) fasta scores%3B opt: 287%2C z-score: 358.8%2C E(): 1.1e-12%2C 53.4%25 identity in 73 aa overlap) and SW:SECG_ECOLI SecG%2C membrane protein involved in protein translocation across the cytoplasmic membrane%2C (110 aa) fasta scores%3B opt: 118%2C z-score: 157.8%2C E(): 0.17%2C (26.2%25 identity in 65 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene1944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1944 SCO1945 SCO1945 tpiA tpiA 2078015 2078791 - triosephosphate isomerase Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate gene gene1945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1945 SCO1946 SCO1946 pgk pgk 2078797 2080008 - phosphoglycerate kinase Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway gene gene1946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1946 SCO1947 SCO1947 gap1 gap1 2080143 2081153 - glyceraldehyde-3-phosphate dehydrogenase SCC54.07c%2C gap1%2C glyceraldehyde-3-phosphate dehydrogenase%2C len: 336aa%3B member of a highly conserved family of proteins eg. SW:G3P_BACST gap%2C glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus (334 aa) fasta scores%3B opt: 1477%2C z-score: 1657.1%2C E(): 0%2C (67.9%25 identity in 333 aa overlap). Contains Pfam match to entry PF00044 gpdh%2C glyceraldehyde 3-phosphate dehydrogenases%2C score 725.60%2C E-value 2.2e-214. gene gene1947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1947 SCO1948 SCO1948 SCC54.08c SCC54.08c 2081381 2084380 - zinc-binding carboxypeptidase SCC54.08c%2C possible zinc-binding carboxypeptidase%2C len: 999 aa%3B N-terminal region similar to many carboxypeptidases eg. SW:CBPS_STRGR zinc-carboxypeptidase from Streptomyces griseus (451 aa) fasta scores%3B opt: 565%2C z-score: 581.4%2C E(): 4.4e-25%2C (31.8%25 identity in 456 aa overlap). Contains PS00132 Zinc carboxypeptidases%2C zinc-binding region 1 signature and Pfam match to entry PF00246 Zn_carbOpept%2C Zinc carboxypeptidase%2C score 143.40%2C E-value 4e-39. Also contains probable N-terminal signal sequence. gene gene1948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1948 SCO1949 SCO1949 SCC54.09c SCC54.09c 2084468 2084563 - hypothetical protein SCC54.09c%2C unknown%2C len: 31aa%3B designated based on Hidden-Markov Model prediction. gene gene1949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1949 SCO1950 SCO1950 SCC54.10c SCC54.10c 2084575 2085561 - hypothetical protein SCC54.10c%2C hypothetical protein%2C len: 324 aa%3B similar to TR:P71692 (EMBL:Z80108) hypothetical protein from Mycobacterium tuberculosis (325 aa) fasta scores%3B opt: 1495%2C z-score: 1704.7%2C E(): 0%2C (70.6%25 identity in 320 aa overlap). gene gene1950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1950 SCO1951 SCO1951 SCC54.11c SCC54.11c 2085558 2086649 - hypothetical protein SCC54.11c%2C unknown%2C len: 363aa%3B similar to many hypothetical proteins eg. SW:YR40_MYCTU from Mycobacterium tuberculosis (342 aa) fasta scores%3B opt: 1047%2C z-score: 1131.4%2C E(): 0%2C (54.5%25 identity in 308 aa overlap) gene gene1951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1951 SCO1952 SCO1952 SCC54.12c SCC54.12c 2086657 2087673 - hypothetical protein SCC54.12c%2C unknown%2C len: 338aa%3B similar to many hypothetical proteins e.g. SW:YR39_MYCTU hypothetical protein from Mycobacterium tuberculosis (301 aa) fasta scores%3B opt: 1071%2C z-score: 1215.8%2C E(): 0%2C (55.6%25 identity in 284 aa overlap) gene gene1952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1952 SCO1953 SCO1953 uvrC uvrC 2087670 2089856 - excinuclease ABC subunit C The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision gene gene1953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1953 SCO1954 SCO1954 SCC54.14 SCC54.14 2090209 2091159 + hypothetical protein SCC54.14%2C unknown%2C len: 316aa gene gene1954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1954 SCO1955 SCO1955 SCC54.15c SCC54.15c 2091177 2091602 - iron sulfur binding protein SCC54.15c%2C possible iron sulphur binding membrane lipoprotein%2C len: 141aa%3B similar to many of this type eg. SW:UCRI_CHLLT cytochrome B6-F iron-sulphur subunit%2C petC from chlorobium limicola (180 aa) fasta scores%3B opt: 197%2C z-score: 225.2%2C E(): 3.1e-05%2C (33.3%25 identity in 108 aa overlap). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene1955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1955 SCO1956 SCO1956 SCC54.16 SCC54.16 2091825 2092931 + LacI family transcription regulator SCC54.16%2C probable transcriptional regulator (lacI family)%2C len: 368 aa%3B similar to many lacI family transcriptional regulators e.g. SW:RBSR_ECOLI RbsR%2C ribose operon repressor from Escherichia coli (329 aa) fasta scores%3B opt: 611%2C z-score: 696.2%2C E(): 1.8e-31%2C (34.2%25 identity in 336 aa overlap). Contains PS00356 Bacterial regulatory proteins%2C lacI family signature and Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C score 102.80%2C E-value 6.7e-27. Also contains Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C score 36.60%2C E-value 7.4e-09 which corresponds to a probable helix-turn-helix at 3-24aa (+5.62 SD). gene gene1956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1956 SCO1957 SCO1957 SCC54.17 SCC54.17 2092928 2093836 + fructokinase SCC54.17%2C probable fructokinase%2C len: 302 aa%3B similar to many e.g. SW:SCRK_RHILT Frk%2C fructokinase from Rhizobium leguminosarum biovar trifolii (326 aa) fasta scores%3B opt: 617%2C z-score: 682.4%2C E(): 1.1e-30%2C (41.0%25 identity in 288 aa overlap). Contains PS00584 pfkB family of carbohydrate kinases signature 2 and Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase%2C score 132.90%2C E-value 9.6e-41 gene gene1957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1957 SCO1958 SCO1958 uvrA uvrA 2094274 2097318 - excinuclease ABC subunit A The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB%2C the uvrA molecules dissociate gene gene1958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1958 SCO1959 SCO1959 SCC54.19 SCC54.19 2097542 2098228 + mycothiol-dependent maleylpyruvate isomerase in Corynebacterium glutamicum this enzyme catalyzes the conversion of maleylpyruvate into fumarylpyruvate in a glutathione-independent gentisate pathway%3B dependent on mycothiol gene gene1959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1959 SCO1960 SCO1960 SCC54.20 SCC54.20 2098289 2098945 + hydrolase SCC54.20%2C possible hydrolase%2C len: 218aa%3B similar to many hypothetical proteins eg. TR:O06154 (EMBL:Z95554) hypothetical protein from Mycobacterium tuberculosis fasta scores%3B opt: 732. z-score: 872.3. E(): 0%2C (52.3%25 identity in 220 aa overlap). Also has a region of similarity to SW:GLO2_RHOBL probable hydrocylglutathione hydrolase from Rhodopseudomonas blastica (255 aa) fasta scores%3B opt: 275%2C z-score: 333.2%2C E(): 3e-11%2C (33.7%25 identity in 193 aa overlap). gene gene1960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1960 SCO1961 SCO1961 aroQ aroQ 2099149 2099622 - 3-dehydroquinate dehydratase catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis gene gene1961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1961 SCO1962 SCO1962 SCC54.22c SCC54.22c 2099713 2100813 - ionic transporter SCC54.22c%2C probable ionic transporter%2C len: 366 aa%3B similar to many egs. TR:O53910 (EMBL:AL022001) ionic transporter from Mycobacterium tuberculosis (360 aa) fasta scores%3B opt: 1466%2C z-score: 1650.6%2C E(): 0%2C (69.4%25 identity in 356 aa overlap) and SW:CHAA_ECOLI ChaA%2C calcium/proton antiporter from Escherichia coli (366 aa) fasta scores%3B opt: 668%2C z-score: 756.2%2C E(): 0%2C (34.7%25 identity in 352 aa overlap). Contains several probable membrane spanning hydrophobic regions. gene gene1962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1962 SCO1963 SCO1963 SCC54.23c SCC54.23c 2100946 2101947 - integral membrane export protein SCC54.23c%2C probable integral membrane export protein%2C len: 333aa%3B similar to many egs. TR:O33228 (EMBL:Z98209) hypothetical protein from Mycobacterium tuberculosis (397 aa) fasta scores%3B opt: 879%2C z-score: 1040.7%2C E(): 0%2C (46.6%25 identity in 326 aa overlap) and SW:TERC_ALCSP plasmid determinant for resistance to tellurium anions from plasmid pMJ606 of Alcaligenes sp. (346 aa) fasta scores%3B opt: 249%2C z-score: 299.8%2C E(): 2.2e-09%2C (31.8%25 identity in 333 aa overlap). Contains several probable membrane spanning hydrophobic regions. gene gene1963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1963 SCO1964 SCO1964 SCC54.24c SCC54.24c 2102200 2104215 - export associated protein SCC54.24c%2C possible export associated protein%2C len: 671aa%3B prediction based on the predicted function of surrounding genes and the short region (67-162aa) of similarity to TR:Q52357 (EMBL:L38824) terD%2C associated with phage inhibition%2C colicin resistance and tellurite resistance from Serratia marcescens IncHI2 plasmid R478 blast scores%3B E%3D2.1e-12%2C Identities %3D 40/98 (40%25)%2C Positives %3D 55/98 (56%25) which may represent an active site. gene gene1964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1964 SCO1965 SCO1965 SCC54.25c SCC54.25c 2104340 2104918 - export associated protein SCC54.25c%2C possible export associated protein%2C len: 192aa%3B similar to many associated with plasmid borne resistance export systems egs. TR:Q52353 (EMBL:L38824) from the IncHI2 plasmid R478 of Serratia marcescens (193 aa) fasta scores%3B opt: 497%2C z-score: 593.2%2C E(): 9.8e-26%2C (42.2%25 identity in 192 aa overlap) and SW:TERD_ALCSP terD%2C tellurium resistance protein from the pMER610 plasmid of Alcaligenes sp. (192 aa) fasta scores%3B opt: 357%2C z-score: 429.6%2C E(): 1.3e-16%2C (37.2%25 identity in 188 aa overlap). gene gene1965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1965 SCO1966 SCO1966 SC3C9.01c SC3C9.01c 2105061 2107199 - excinuclease ABC subunit B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands%2C where it probes for the presence of a lesion gene gene1966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1966 SCO1967 SCO1967 SC3C9.02c SC3C9.02c 2107239 2108117 - hypothetical protein SC3C9.02c%2C possible integral membrane protein%2C len: 292 aa%3B similar to TR:Q9KZI4 (EMBL:AL353863) Streptomyces coelicolor integral membrane protein SCG8A.15c%2C 244 aa%3B fasta scores: opt: 703 Z-score: 726.3 bits: 142.1 E(): 7.6e-33%3B 48.430%25 identity in 223 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1967 SCO1968 SCO1968 SC3C9.03 SC3C9.03 2108409 2109278 + hydrolase SC3C9.03%2C probable hydrolase%2C len: 289 aa%3B similar to SW:GLPQ_BACSU (EMBL:Z26522) Bacillus subtilis glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) GlpQ%2C 293 aa%3B fasta scores: opt: 495 Z-score: 576.9 bits: 114.7 E(): 1.6e-24%3B 34.114%25 identity in 299 aa overlap. Contains possible cleavable N-terminal region signal peptide sequence gene gene1968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1968 SCO1969 SCO1969 SC3C9.04 SC3C9.04 2109316 2109870 + DNA-methyltransferase SC3C9.04%2C possible DNA-methyltransferase%2C len: 184 aa%3B similar to SW:OGT_MYCPA (EMBL:AJ011838) Mycobacterium paratuberculosis methylated-DNA protein-cysteine methyltransferase (EC 2.1.1.63) Ogt%2C 165 aa%3B fasta scores: opt: 355 Z-score: 399.1 bits: 80.3 E(): 1.3e-14%3B 40.964%25 identity in 166 aa overlap. Contains Pfam matches to entries PF02870 Methyltransf_1N%2C 6-O-methylguanine DNA methyltransferase%2C ribonuclease-like domain and PF01035 Methyltransf_1%2C 6-O-methylguanine DNA methyltransferase%2C DNA binding domain and match to Prosite entry PS00374 Methylated-DNA--protein-cysteine methyltransferase active site gene gene1969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1969 SCO1970 SCO1970 SC3C9.05c SC3C9.05c 2109895 2110338 - dioxygenase SC3C9.05c%2C possible dioxygenase%2C len: 147 aa%3B similar to TR:Q9I0T8 (EMBL:AE004682) Pseudomonas aeruginosa probable ring-cleaving dioxygenase PA2546%2C 143 aa%3B fasta scores: opt: 178 Z-score: 231.1 bits: 48.7 E(): 2.9e-05%3B 33.333%25 identity in 135 aa overlap. Contains Pfam match to entry PF00903 Glyoxalase%2C Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily gene gene1970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1970 SCO1971 SCO1971 SC3C9.06 SC3C9.06 2110465 2111370 + hypothetical protein SC3C9.06%2C conserved hypothetical protein%2C len: 301 aa%3B similar to TR:BAB36480 (EMBL:AP002560) Escherichia coli O157:H7 hypothetical 32.9 kDa protein ECS3057%2C 312 aa%3B fasta scores: opt: 837 Z-score: 923.0 bits: 178.9 E(): 8.4e-44%3B 48.495%25 identity in 299 aa overlap gene gene1971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1971 SCO1972 SCO1972 SC3C9.07 SC3C9.07 2111367 2112302 + sugar kinase SC3C9.07%2C probable sugar kinase%2C len: 311 aa%3B similar to SW:SCRK_KLEPN (EMBL:X61004) Klebsiella pneumoniae fructokinase (EC 2.7.1.4) ScrK%2C 307 aa%3B fasta scores: opt: 294 Z-score: 321.0 bits: 67.5 E(): 2.9e-10%3B 31.541%25 identity in 279 aa overlap. Contains Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase and match to Prosite entry PS00584 pfkB family of carbohydrate kinases signature 2 gene gene1972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1972 SCO1973 SCO1973 SC3C9.08c SC3C9.08c 2112316 2113110 - hypothetical protein SC3C9.08c%2Cconserved hypothetical protein%2C len: 264 aa%3B low similarity to SW:YT37_STRFR (EMBL:M29297) Streptomyces fradiae hypothetical 37.1 kDa protein in transposon TN4556%2C 345 aa%3B fasta scores: opt: 224 Z-score: 256.6 bits: 55.5 E(): 1.1e-06%3B 29.259%25 identity in 270 aa overlap gene gene1973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1973 SCO1974 SCO1974 SC3C9.09 SC3C9.09 2113356 2114481 + gene gene1974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1974 SCO1975 SCO1975 SC3C9.10c SC3C9.10c 2114500 2115132 - hypothetical protein SC3C9.10c%2C unknown%2C len: 210 aa gene gene1975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1975 SCO1976 SCO1976 SC3C9.11 SC3C9.11 2115347 2115826 + hypothetical protein SC3C9.11%2C possible integral membrane protein%2C len: 159 aa%3B similar to TR:BAB50721 (EMBL:AP003003) Rhizobium loti MLR3943 protein%2C 158 aa%3B fasta scores: opt: 409 Z-score: 476.8 bits: 94.4 E(): 6e-19%3B 40.667%25 identity in 150 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene1976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1976 SCO1977 SCO1977 SC3C9.12 SC3C9.12 2115989 2117479 + oxidoreductase function undetermined%3B similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain gene gene1977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1977 SCO1978 SCO1978 SC3C9.13c SC3C9.13c 2117630 2117905 - AbaA-like protein SC3C9.13c%2C possible AbaA-like protein%2C len: 91 aa%3B similar to TR:Q9F3E1 (EMBL:AL450289) Streptomyces coelicolor AbaA-like protein SC2H2.14%2C 89 aa%3B fasta scores: opt: 371 Z-score: 479.1 bits: 93.2 E(): 4.5e-19%3B 69.863%25 identity in 73 aa overlap and to TR:Q53896 (EMBL:X60316) Streptomyces coelicolor AbaA gene (regulator) SCF42.13%2C 75 aa%3B fasta scores: opt: 220 Z-score: 293.4 bits: 58.6 E(): 9.9e-09%3B 50.000%25 identity in 74 aa overlap gene gene1978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1978 SCO1979 SCO1979 SC3C9.14c SC3C9.14c 2117906 2118766 - DNA-binding protein SC3C9.14c%2C probable DNA-binding protein%2C len: 286 aa%3B similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor DNA-binding proteins SC2H2.13%2C 290 aa%3B fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58%3B 55.000%25 identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c%2C 287 aa%3B fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71%3B 69.338%25 identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD) gene gene1979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1979 SCO1980 SCO1980 SC3C9.15 SC3C9.15 2119050 2119763 + hypothetical protein SC3C9.15%2C hypothetical protein%2C len: 237 aa%3B similar to TR:O86675 (EMBL:AL031371) Streptomyces coelicolor hypothetical 21.4 kDa protein SC4G2.02c%2C 196 aa%3B fasta scores: opt: 248 Z-score: 277.4 bits: 58.4 E(): 7.7e-08%3B 34.239%25 identity in 184 aa overlap. Contains Pfam match to entry PF02518 HATPase_c%2C Histidine kinase-%2C DNA gyrase B-%2C phytochrome-like ATPase and a TTA leucine codon%2C possible target for bldA regulation gene gene1980 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1980 SCO1981 SCO1981 SC3C9.16 SC3C9.16 2119760 2120194 + hypothetical protein SC3C9.16%2C hypothetical protein%2C len: 144 aa%3B similar to C-terminal part of TR:Q9F397 (EMBL:AL450165) Streptomyces coelicolor hypothetical 21.9 kDa protein SC5F1.32c%2C 205 aa%3B fasta scores: opt: 395 Z-score: 465.9 bits: 92.6 E(): 2.4e-18%3B 43.165%25 identity in 139 aa overlap gene gene1981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1981 SCO1982 SCO1982 SC3C9.17c SC3C9.17c 2120213 2120395 - hypothetical protein SC3C9.17c%2C hypothetical protein%2C len: 60 aa%3B similar to SCP1 borne TR:Q9AD30 (EMBL:AL590463) Streptomyces coelicolor hypothetical 6.3 kDa protein SCP1.120%2C 59 aa%3B fasta scores: opt: 224 Z-score: 325.4 bits: 63.6 E(): 1.6e-10%3B 66.667%25 identity in 45 aa overlap gene gene1982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1982 SCO1983 SCO1983 SC3C9.18c SC3C9.18c 2120551 2121240 - hypothetical protein SC3C9.18c%2C conserved hypothetical protein%2C len: 229 aa%3B similar to TR:BAB49166 (EMBL:AP002998) Rhizobium loti MLR1911 protein%2C 249 aa%3B fasta scores: opt: 689 Z-score: 839.8 bits: 162.8 E(): 3.6e-39%3B 50.000%25 identity in 234 aa overlap. Contains a TTA leucine codon%2C possible target for bldA regulation gene gene1983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1983 SCO1984 SCO1984 SC3C9.19c SC3C9.19c 2121378 2122775 - hydrolase SC3C9.19c%2C probable hydrolase%2C len: 465 aa%3B similar to SW:ATZA_PSESD (EMBL:U55933) Pseudomonas sp. atrazine chlorohydrolase (EC 3.8.1.8) AtzA%2C 474 aa%3B fasta scores: opt: 448 Z-score: 490.2 bits: 100.0 E(): 1.1e-19%3B 33.258%25 identity in 445 overlap. Contains Pfam match to entry PF01685 ATZ_TRZ%2C Chlorohydrolase gene gene1984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1984 SCO1985 SCO1985 SC3C9.20c SC3C9.20c 2122775 2124631 - hypothetical protein SC3C9.20c%2C possible integral membrane protein%2C len: 618 aa%3B similar to TR:Q9FBT3 (EMBL:AL391072) Streptomyces coelicolor integral membrane protein SC9A4.21%2C 645 aa%3B fasta scores: opt: 889 Z-score: 886.0 bits: 174.1 E(): 9.6e-42%3B 35.055%25 identity in 639 aa overlap. Contains possible hydrophobic membrane spanning regions at the N-terminal domain gene gene1985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1985 SCO1986 SCO1986 SC3C9.21c SC3C9.21c 2124799 2125581 - hypothetical protein SC3C9.21c%2C hypothetical protein%2C len: 260 aa%3B low similarity to TR:O54361 (EMBL:U73025) Staphylococcus aureus transposon TN5405 ORFX (hypothetical 32.9 kDa protein)%2C 289 aa%3B fasta scores: opt: 241 Z-score: 283.5 bits: 60.2 E(): 3.5e-08%3B 28.251%25 identity in 223 aa overlap gene gene1986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1986 SCO1987 SCO1987 SC3C9.22 SC3C9.22 2125668 2126168 + hypothetical protein SC7H2.01%2C partial CDS%2C unknown%2C len: >90aa%3B similar to the C-terminal region of several hypothetical proteins both prokaryote and eukaryote egs. SW:Y709_SYNY3 hypothetical protein from Synechocystis sp. strain PCC6803 (130 aa) fasta scores%3B opt: 100%2C z-score: 145.9%2C E(): 0.84%2C (34.9%25 identity in 83 aa overlap) and SW:UK14_CAPHI from Capra hircus (goat) (137 aa) fasta scores%3B opt: 96%2C z-score: 140.4%2C E(): 1.7%2C (34.6%25 identity in 81 aa overlap).~SC3C9.22%2C conserved hypothetical protein (fragment)%2C len: >115 aa%3B similar to N-terminal region of TR:BAB48518 (EMBL:AP002996) Rhizobium loti MLL1058 protein%2C 148 aa%3B fasta scores: opt: 175 Z-score: 218.8 bits: 46.1 E(): 0.00014%3B 40.789%25 identity in 76 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C YjgF family gene gene1987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1987 SCO1988 SCO1988 SC7H2.02 SC7H2.02 2126165 2126716 + hypothetical protein SC7H2.02%2C possible acetyltransferase%2C len: 183 aa%3B similar to SW:YIAC_ECOLI hypothetical protein from Escherichia coli (146 aa) fasta scores%3B opt: 178%2C z-score: 227.9%2C E(): 2.3e-05%2C (27.2%25 identity in 147 aa overlap). Also has region of similarity to several acetyltransferases eg. TR:Q08414 (EMBL:X73149) nourseothricin acetyltransferase from Streptomyces noursei (189 aa) fasta scores%3B opt: 115%2C z-score: 150.4%2C E(): 0.47%2C (40.2%25 identity in 82 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene1988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1988 SCO1989 SCO1989 SC7H2.03c SC7H2.03c 2126802 2127773 - aminopeptidase SC7H2.03c%2C probable aminopeptidase%2C len: 323 aa%3B similar to many proline aminopeptidases e.g. SW:PIP_XANCI proline iminopeptidase from Xanthomonas campestris pv. citri (313 aa) fasta scores%3B opt: 848%2C z-score: 979.3%2C E(): 0%2C (44.4%25 identity in 320 aa overlap). Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene1989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1989 SCO1990 SCO1990 SC7H2.04c SC7H2.04c 2127828 2128541 - hypothetical protein SC7H2.04c%2C unknown%2C len: 237aa%3B similar to SW:Y08N_MYCTU hypothetical protein from Mycobacterium tuberculosis (350 aa) fasta scores%3B opt: 870%2C z-score: 990.4%2C E(): 0%2C (57.1%25 identity in 231 aa overlap). gene gene1990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1990 SCO1991 SCO1991 SC7H2.05 SC7H2.05 2128658 2129218 + hypothetical protein SC7H2.05%2C hypothetical protein%2C len: 186 aa%3B similar to SW:YRFH_ECOLI hypothetical protein from Escherichia coli (133 aa) fasta scores%3B opt: 228%2C z-score: 249.5%2C E(): 1.4e-06%2C (35.2%25 identity in 122 aa overlap). gene gene1991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1991 SCO1992 SCO1992 SC7H2.06c SC7H2.06c 2129270 2129776 - hypothetical protein SC7H2.06c%2C possible integral membrane protein%2C len: 168aa%3B contains possible membrane spanning hydrophobic regions. gene gene1992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1992 SCO1993 SCO1993 SC7H2.07c SC7H2.07c 2129838 2130524 - hypothetical protein SC7H2.07c%2C unknown%2C len: 228aa gene gene1993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1993 SCO1994 SCO1994 SC7H2.08 SC7H2.08 2130596 2130952 + hypothetical protein SC7H2.08%2C possible integral membrane protein%2C len: 118aa%3B contains possible membrane spanning hydrophobic region. gene gene1994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1994 SCO1995 SCO1995 SC7H2.09c SC7H2.09c 2130961 2131341 - hypothetical protein SC7H2.09c%2C unknown%2C len: 126aa gene gene1995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1995 SCO1996 SCO1996 coaE coaE 2131391 2131993 - dephospho-CoA kinase SC7H2.10c%2C coaE%2C dephospho-CoA kinase%2C len: 200 aa%3B similar to many e.g. SW:YTAG_BACSU hypothetical protein from Bacillus subtilis (197 aa) fasta scores%3B opt: 508%2C z-score: 575.3%2C E(): 1e-24%2C (42.2%25 identity in 192 aa overlap). Also similar to the N-terminal half of SW:Y14N_MYCTU hypothetical protein from Mycobacterium tuberculosis (407 aa) fasta scores%3B opt: 672%2C z-score: 751.8%2C E(): 0%2C (54.3%25 identity in 199 aa overlap). Similar to SW:COAE_ECOLI (EMBL:AE000119) Escherichia coli dephospho-CoA kinase (EC 2.7.1.24) CoaE or B0103%2C 206 aa%3B fasta scores: opt: 444 Z-score: 491.1 E(): 1e-19%3B 44.509%25 identity in 173 aa overlap. Contains Pfam match to entry PF01121 UPF0038%2C Uncharacterized protein family UPF0038 and Prosite match to PS01294 Uncharacterized protein family UPF0038 signature gene gene1996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1996 SCO1997 SCO1997 SC7H2.11c SC7H2.11c 2132026 2132964 - hypothetical protein SC7H2.11c%2C unknown%2C len: 312 aa%3B similar to TR:O07213 (EMBL:Z96072) hypothetical protein from Mycobacterium tuberculosis (324 aa) fasta scores%3B opt: 770%2C z-score: 866.1%2C E(): 0%2C (40.9%25 identity in 286 aa overlap) gene gene1997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1997 SCO1998 SCO1998 rpsA rpsA 2133121 2134629 - 30S ribosomal protein S1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit%3B autoregulates expression via a C-terminal domain%3B in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats%3B the S1 nucleic acid-binding domain is found associated with other proteins gene gene1998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1998 SCO1999 SCO1999 SC7H2.13 SC7H2.13 2135154 2135816 + hypothetical protein SC7H2.13%2C hypothetical protein%2C len: 220 aa%3B similar to many some of which are proposed to have methyltransferase activity egs. TR:CAB44537 (EMBL:AL078618) ubiquinone/menaquinone methyltransferase from Streptomyces coelicolor (231 aa) fasta scores%3B opt: 199%2C z-score: 247.0%2C E(): 2e-06%2C (40.4%25 identity in 104 aa overlap) and TR:O06424 (EMBL:Z95558) hypothetical protein from Mycobacterium tuberculosis (234 aa) fasta scores%3B opt: 191%2C z-score: 237.3%2C E(): 6.8e-06%2C (42.7%25 identity in 96 aa overlap). gene gene1999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO1999 SCO2000 SCO2000 SC7H2.14 SC7H2.14 2135883 2138879 + ATP-binding RNA helicase SC7H2.14%2C possible ATP-binding RNA helicase%2C len: 998 aa%3B similar to many proposed helicases eg. SW:HRPB_ECOLI ATP-dependent helicase from Escherichia coli (809 aa) fasta scores%3B opt: 889%2C z-score: 783.0%2C E(): 0%2C (33.6%25 identity in 998 aa overlap). Contains a repeat region which does not appear in homologues: 8 x GDDRR(R/G)QRATVES. Also contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00037 Myb DNA-binding domain repeat signature 1. gene gene2000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2000 SCO2001 SCO2001 SC7H2.15c SC7H2.15c 2138930 2140723 - hypothetical protein SC7H2.15c%2C hypothetical protein%2C len: 597 aa%3B similar to TR:O86313 (EMBL:Z98260) hypothetical protein from Mycobacterium tuberculosis (411 aa) fasta scores%3B opt: 548%2C z-score: 447.1%2C E(): 1.4e-17%2C (33.7%25 identity in 380 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene2001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2001 SCO2002 SCO2002 SC7H2.16c SC7H2.16c 2141042 2141398 - hypothetical protein SC7H2.16c%2C unknown%2C len: 118aa gene gene2002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2002 SCO2003 SCO2003 polA polA 2141659 2144382 - DNA polymerase I has 3'-5' exonuclease%2C 5'-3' exonuclease and 5'-3'polymerase activities%2C primarily functions to fill gaps during DNA replication and repair gene gene2003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2003 SCO2004 SCO2004 SC7H2.18 SC7H2.18 2144639 2146918 + formate dehydrogenase SC7H2.18%2C possible formate dehydrogenase%2C len: 759 aa%3B similar to many formate dehydrogenase e.g. SW:FDHF_ECOLI formate dehydrogenase H from Escherichia coli (715 aa) fasta scores%3B opt: 386%2C z-score: 441.8%2C E(): 2.8e-17%2C (26.3%25 identity in 670 aa overlap). Also similar to SW:YX31_MYCTU hypothetical protein from Mycobacterium tuberculosis (779 aa) fasta scores%3B opt: 3038%2C z-score: 3497.1%2C E(): 0%2C (59.7%25 identity in 767 aa overlap). gene gene2004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2004 SCO2005 SCO2005 SC7H2.19 SC7H2.19 2146962 2147501 + hypothetical protein SC7H2.19%2C unknown%2C len: 179aa%3B similar to many of undefined function egs. SW:YBDB_ECOLI hypothetical protein from Escherichia coli (137 aa) fasta scores%3B opt: 339%2C z-score: 407.0%2C E(): 2.5e-15%2C (50.0%25 identity in 116 aa overlap) and SW:CMA2_BACSU ComA protein%2C involved in competence (126 aa) fasta scores%3B opt: 312%2C z-score: 376.3%2C E(): 1.3e-13%2C (44.5%25 identity in 110 aa overlap). gene gene2005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2005 SCO2006 SCO2006 SC7H2.20 SC7H2.20 2147859 2148404 + hypothetical protein SC7H2.20%2C unknown%2C len: 181aa gene gene2006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2006 SCO2007 SCO2007 SC7H2.21 SC7H2.21 2148401 2148997 + hypothetical protein SC7H2.21%2C unknown%2C len: 198aa gene gene2007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2007 SCO2008 SCO2008 SC7H2.22 SC7H2.22 2149264 2150520 + branched-chain amino acid ABC transporter substrate-binding protein SC7H2.22%2C possible branched-chain amino acid binding protein%2C len: 481aa%3B similar to many eg. SW:LIVK_ECOLI leucine-specific binding protein from Escherichia coli (369 aa) fasta scores%3B opt: 360%2C z-score: 374.0%2C E(): 1.6e-13%2C (28.4%25 identity in 352 aa overlap). Contains possible N-terminal signal sequence. gene gene2008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2008 SCO2009 SCO2009 SC7H2.23 SC7H2.23 2150635 2151567 + branched-chain amino acid ABC transporter permease SC7H2.23%2C probable branched-chain amino acid ABC transporter permease%2C len: 310aa%3B similar to many eg. SW:LIVH_SALTY high affinity branched-chain amino acid ABC transporter permease from Salmonella typhimurium (308 aa) fasta scores%3B opt: 711%2C z-score: 782.4%2C E(): 0%2C (43.5%25 identity in 306 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene2009 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2009 SCO2010 SCO2010 SC7H2.24 SC7H2.24 2151573 2153399 + branched-chain amino acid ABC transporter permease SC7H2.24%2C probable branched-chain amino acid ABC transporter permease%2C len: 310aa%3B region from 200-608aa similar to many eg. SW:LIVM_SALTY high affinity branched-chain amino acid ABC transporter permease from Salmonella typhimurium (425 aa) fasta scores%3B opt: 633%2C z-score: 702.7%2C E(): 8.1e-32%2C (36.8%25 identity in 400 aa overlap). gene gene2010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2010 SCO2011 SCO2011 SC7H2.25 SC7H2.25 2153405 2154334 + ABC transporter ATP-binding protein SC7H2.25%2C probable branched-chain amino acid transport ATP-binding protein%2C len: 309aa%3B similar to many eg. SW:LIVG_ECOLI branched-chain amino acid transport ATP-binding protein from Escherichia coli (255 aa) fasta scores%3B opt: 770%2C z-score: 837.9%2C E(): 0%2C (46.8%25 identity in 250 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene2011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2011 SCO2012 SCO2012 SC7H2.26 SC7H2.26 2154331 2155047 + ABC transporter ATP-binding protein SC7H2.26%2C probable branched-chain amino acid transport ATP-binding protein%2C len: 238aa%3B similar to many eg. SW:LIVF_ECOLI branched-chain amino acid transport ATP-binding protein from Escherichia coli (237 aa) fasta scores%3B opt: 774%2C z-score: 860.8%2C E(): 0%2C (52.4%25 identity in 233 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. gene gene2012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2012 SCO2013 SCO2013 SC7H2.27c SC7H2.27c 2155123 2155779 - two-component system response regulator SC7H2.27c%2C probable two-component system response regulator%2C len: 218aa%3B similar to many eg. TR:Q53894 (EMBL:U51332) AbsA2 response regulator from Streptomyces coelicolor (222 aa) fasta scores%3B opt: 313%2C z-score: 359.0%2C E(): 1.1e-12%2C (36.1%25 identity in 155 aa overlap). Also similar to TR:O06143 (EMBL:Z95554) hypothetical protein from Mycobacterium tuberculosis (205 aa) fasta scores%3B opt: 880%2C z-score: 986.3%2C E(): 0%2C (69.4%25 identity in 196 aa overlap). Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain. gene gene2013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2013 SCO2014 SCO2014 pyk1 pyk1 2156337 2157773 - pyruvate kinase SC7H2.28c%2C pyk1%2C pyruvate kinase%2C len: 478 aa%3B strongly similar to many e.g. SW:KPYK_CORGL pyruvate kinase from Corynebacterium glutamicum (475 aa) fasta scores%3B opt: 1800%2C z-score: 2008.1%2C E(): 0%2C (59.6%25 identity in 473 aa overlap). Contains Pfam match to entry PF00224 PK%2C Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature. gene gene2015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2014 SCO2015 SCO2015 SC7H2.29 SC7H2.29 2157990 2159798 + nucleotidase SC7H2.29%2C possible nucleotidase%2C len: 602 aa%3B similar to many e.g. SW:CN16_ECOLI periplasmic 2'%2C3'-cyclic phosphodiesterase from Escherichia coli (647 aa) fasta scores%3B opt: 577%2C z-score: 618.9%2C E(): 3.8e-27%2C (32.3%25 identity in 595 aa overlap). Contains Pfam match to entry PF01009 5_nucleotidase%2C 5'-nucleotidase and Prosite match to PS00786 5'-nucleotidase signature 2. Also has possible N-terminal signal sequence. gene gene2016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2015 SCO2016 SCO2016 SC7H2.30c SC7H2.30c 2159817 2161229 - monooxygenase SC7H2.30c%2C possible monooxygenase%2C len: 470 aa%3B similar to many e.g. SW:IUCD_ECOLI L-lysine 6-monooxygenase from Escherichia coli (425 aa) fasta scores%3B opt: 393%2C z-score: 466.0%2C E(): 1.2e-18%2C (34.4%25 identity in 425 aa overlap). gene gene2017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2016 SCO2017 SCO2017 SC7H2.31c SC7H2.31c 2161226 2162584 - amino acid decarboxylase SC7H2.31c%2C possible amino acid decarboxylase%2C len: 452aa%3B similar to many eg. TR:Q43908 (EMBL:D55724) L-2%2C4-diaminobutyrate decarboxylase of Acinetobacter baumannii (510 aa) fasta scores%3B opt: 532%2C z-score: 544.9%2C E(): 5e-23%2C (31.8%25 identity in 431 aa overlap). Contains Pfam match to entry PF00282 pyridoxal_deC%2C Pyridoxal-dependent decarboxylase conserved domain. gene gene2018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2017 SCO2018 SCO2018 SC7H2.32c SC7H2.32c 2162746 2165253 - aminopeptidase SC7H2.32c%2C possible aminopeptidase%2C len: 835aa%3B similar to many eg. SW:AMPN_LACDL lysyl aminopeptidase from Lactobacillus delbruckii ssp. lactis (842 aa) fasta scores%3B opt: 705%2C z-score: 805.5%2C E(): 0%2C (27.7%25 identity in 622 aa overlap). Also similar to TR:O53194 (EMBL:AL021246) aminopeptidase from Mycobacterium tuberculosis (861 aa) fasta scores%3B opt: 1490%2C z-score: 1707.1%2C E(): 0%2C (39.6%25 identity in 867 aa overlap). Contains Pfam match to entry PF01433 Peptidase_M1%2C Peptidase family M1 and Prosite match to PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. gene gene2019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2018 SCO2019 SCO2019 SC7H2.33c SC7H2.33c 2165374 2165724 - chorismate mutase catalyzes the interconversion of chorismate to prephenate gene gene2020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2019 SCO2020 SCO2020 SC7H2.34 SC7H2.34 2165859 2166758 + hypothetical protein SC7H2.34%2C unknown%2C len: 299aa gene gene2021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2020 SCO2021 SCO2021 SC7H2.35 SC7H2.35 2166835 2167428 + hypothetical protein SC7H2.35%2C hypothetical protein%2C len: 197 aa%3B similar to other hypothetical protein eg. TR:O06384 (EMBL:Z95436) hypothetical protein from Mycobacterium tuberculosis (240 aa) fasta scores%3B opt: 215%2C z-score: 248.4%2C E(): 1.6e-06%2C (28.1%25 identity in 199 aa overlap). gene gene2022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2021 SCO2022 SCO2022 SC7H2.36c SC7H2.36c 2167476 2168234 - hypothetical protein SC7H2.36c%2C unknown%2C len: 252 aa%3B similar to SW:YCBR_BACSU hypothetical protein from Bacillus subtilis (243 aa) fasta scores%3B opt: 421%2C z-score: 523.5%2C E(): 7.8e-22%2C (32.8%25 identity in 229 aa overlap) gene gene2023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2022 SCO2023 SCO2023 SC3A3.01 SC3A3.01 2168433 2169291 + hypothetical protein SC3A3.01%2C possible membrane protein%2C partial CDS%2C len: >285 aa%3B similar to TR:O53632 (EMBL:AL021926) Mycobacterium tuberculosis transmembrane protein (249 aa)%2C fasta scores%3B opt: 375 z-score: 425.6 E(): 2.3e-16%2C 39.4%25 identity in 282 aa overlap and SCH69.25C (EMBL:AL079308) S.coelicolor possible membrane protein (297 aa) (39.4%25 identity in 284 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene2024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2023 SCO2024 SCO2024 SC3A3.02 SC3A3.02 2169305 2170222 + chitosanase SC3A3.02%2C probable chitosanase (hypothetical protein)%2C len: 305 aa%3B similar to chitosanases e.g. SW:CHIS_STRSQ (EMBL:L07779)%2C csn%2C Streptomyces sp. (strain N174) chitosanase precursor (278 aa)%2C fasta scores%3B opt: 893 z-score: 1036.3 E(): 0%2C 58.4%25 identity in 233 aa overlap. Has an approx. 70 aa N-terminal extension not present in homologues which includes a possible N-terminal signal sequence. Contains Pfam match to entry PF01374 Glyco_hydro_46%2C Glycosyl hydrolase family 46 gene gene2025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2024 SCO2025 SCO2025 gltD gltD 2170384 2171847 - glutamate synthase glutamate synthase is composed of subunits alpha and beta%3B beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase%3B provides electrons to the alpha subunit%2C which binds L-glutamine and 2-oxoglutarate and forms L-glutamate gene gene2026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2025 SCO2026 SCO2026 gltB gltB 2171840 2176384 - glutamate synthase SC3A3.04c%2C gltB%2C probable glutamate synthase large subunit%2C len: 1514 aa%3B similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230)%2C gltB%2C Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa)%2C fasta scores%3B opt: 5662 z-score: 6172.3 E(): 0%2C 56.4%25 identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9%25 identity in 1577 aa overlap) gene gene2027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2026 SCO2027 SCO2027 SC3A3.05c SC3A3.05c 2176826 2177557 - hypothetical protein SC3A3.05c%2C possible membrane protein%2C len: 243 aa%3B unknown function%2C shows weak similarity to TR:Q9ZUA5 (EMBL:AC006069) Arabidopsis thaliana hypothetical protein (250 aa)%2C fasta scores%3B opt: 347 z-score: 387.7 E(): 3e-14%2C 29.7%25 identity in 229 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene2028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2027 SCO2028 SCO2028 SC3A3.06 SC3A3.06 2177792 2179321 + hypothetical protein SC3A3.06%2C possible membrane protein%2C len: 509 aa%3B unknown function%2C probable Ser- and Pro-rich CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains a compound repeat region at the C-terminus consisting of 22 degenerate repeats (19x RSPP(A/D)PD and 3x AHAPAPD). Shows weak similarity to the neighbouring CDS SC3A3.07%2C SC3A3.08 and SC3A3.09 e.g. SC3A3.07 hypothetical protein (425 aa) (32.1%25 identity in 383 aa overlap). Contains a hydrophobic%2C possible membrane-spanning region gene gene2029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2028 SCO2029 SCO2029 SC3A3.07 SC3A3.07 2179318 2180595 + hypothetical protein SC3A3.07%2C hypothetical protein%2C len: 425 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Shows weak similarity to the neighbouring CDS SC3A3.06%2C SC3A3.08 and SC3A3.09 e.g. SC3A3.06 possible membrane protein (509 aa) (32.1%25 identity in 383 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene2030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2029 SCO2030 SCO2030 SC3A3.08 SC3A3.08 2180592 2181770 + hypothetical protein SC3A3.08%2C hypothetical protein%2C len: 392 aa%3B unknown function%2C shows very weak similarity to SW:YH24_ARCFU (EMBL:AE000984) Archaeoglobus fulgidus hypothetical protein (305 aa)%2C fasta scores%3B opt: 147 z-score: 168.3 E(): 0.051%2C 30.3%25 identity in 333 aa overlap. Shows weak similarity to the neighbouring CDS SC3A3.06%2C SC3A3.07 and SC3A3.09 e.g. SC3A3.06 possible membrane protein (509 aa) (33.1%25 identity in 393 aa overlap) gene gene2031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2030 SCO2031 SCO2031 SC3A3.09 SC3A3.09 2181758 2183161 + hypothetical protein SC3A3.09%2C hypothetical protein%2C len: 467 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Shows weak similarity to the neighbouring CDS SC3A3.06%2C SC3A3.07 and SC3A3.08 e.g. SC3A3.06 possible membrane protein (509 aa) (33.1%25 identity in 353 aa overlap). Has a Pro-rich C-terminus gene gene2032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2031 SCO2032 SCO2032 SC3A3.10 SC3A3.10 2183119 2184333 + hypothetical protein SC4G6.01%2C partial CDS%2C unknown%2C len: >35 aa~SC3A3.10%2C hypothetical protein%2C len: 404 aa%3B unknown function%2C similar to both bacterial dehydratases e.g. SW:CAIB_ECOLI (EMBL:X67748) Escherichia coli L-carnitine dehydratase (405 aa)%2C fasta scores%3B opt: 579 z-score: 647.7 E(): 1e-28%2C 28.9%25 identity in 409 aa overlap and to eukaryotic isomerases e.g. TR:O43673 (EMBL:AF047020) Homo sapiens alpha-methylacyl-CoA racemase (382 aa) (31.2%25 identity in 398 aa overlap). Similar to others from S.coelicolor e.g. SC5F2A.13 (EMBL:AL049587) S.coelicolor possible racemase (398 aa) (35.9%25 identity in 404 aa overlap). Present%2C in part%2C in cosmid 4G6 (EMBL:AL096884) as SC4G6.01 gene gene2033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2032 SCO2033 SCO2033 SC4G6.02 SC4G6.02 2184330 2185154 + citrate lyase subunit beta SC4G6.02%2C possible citrate lyase beta chain%2C len: 274 aa%3B similar to SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores%3B opt: 293%2C z-score: 325.3%2C E(): 8.5e-11%2C (33.5%25 identity in 284 aa overlap). gene gene2034 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2033 SCO2034 SCO2034 SC4G6.03c SC4G6.03c 2185228 2186259 - prolipoprotein diacylglyceryl transferase transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein gene gene2035 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2034 SCO2035 SCO2035 SC4G6.04c SC4G6.04c 2186336 2187163 - hypothetical protein SC4G6.04c%2C possible membrane protein%2C len: 275 aa%3B similar to TR:Q9S2S3 (EMBL:AL096884) Streptomyces coelicolor hypothetical protein SC4G6.36%2C 266 aa%3B fasta scores: opt: 519 Z-score: 588.1 E(): 4e-25%3B 34.470%25 identity in 264 aa overlap gene gene2036 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2035 SCO2036 SCO2036 trpA trpA 2187211 2188026 - tryptophan synthase subunit alpha catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis gene gene2037 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2036 SCO2037 SCO2037 SC4G6.06c SC4G6.06c 2188023 2189306 - tryptophan synthase subunit beta catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate gene gene2038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2037 SCO2038 SCO2038 SC4G6.07c SC4G6.07c 2189421 2189612 - hypothetical protein SC4G6.07c%2C unknown%2C len: 63aa%3B previously sequenced therefore identical to TR:O68815 (EMBL:AF054585). gene gene2039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2038 SCO2039 SCO2039 trpC trpC 2189633 2190442 - indole-3-glycerol-phosphate synthase involved in tryptophan biosynthesis%3B amino acid biosynthesis%3B converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water gene gene2040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2039 SCO2040 SCO2040 SC4G6.09c SC4G6.09c 2190560 2191006 - hypothetical protein SC4G6.09c%2C possible membrane protein%2C len: aa%3B similar to TR:O06133 (EMBL:Z95554) hypothetical protein from Mycobacterium tuberculosis (132 aa) fasta scores%3B opt: 245%2C z-score: 301.1%2C E(): 1.9e-09%2C (36.7%25 identity in 128 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene2041 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2040 SCO2041 SCO2041 SC4G6.10c SC4G6.10c 2191109 2191360 - hypothetical protein SC4G6.10c%2C possible membrane protein%2C len: 83aa%3B Contains possible membrane spanning hydrophobic regions. gene gene2042 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2041 SCO2042 SCO2042 SC4G6.11c SC4G6.11c 2191505 2192140 - hypothetical protein SC4G6.11c%2C possible membrane protein%2C len: 211aa%3B similar to TR:O06128 (EMBL:Z95554) hypothetical protein from Mycobacterium tuberculosis (235 aa) fasta scores%3B opt: 155%2C z-score: 174.0%2C E(): 0.023%2C (29.9%25 identity in 224 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene2043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2042 SCO2043 SCO2043 SC4G6.12c SC4G6.12c 2192224 2193732 - anthranilate synthase component I with component II%2C the glutamine amidotransferase%2C catalyzes the formation of anthranilate from chorismate and glutamine gene gene2044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2043 SCO2044 SCO2044 hisI hisI 2193744 2194130 - phosphoribosyl-AMP cyclohydrolase PR-AMP cyclohydrolase%3B functions in histidine biosynthesis from PRPP%3B converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxyamide during the histidine biosynthesis pathway%3B binds zinc and magnesium%3B forms homodimers gene gene2045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2044 SCO2045 SCO2045 SC4G6.14 SC4G6.14 2194212 2194847 + hypothetical protein SC4G6.14%2C unknown%2C len: 211aa%3B similar to TR:P95285 (EMBL:Z84498) hypothetical protein from Mycobacterium tuberculosis (214 aa) fasta scores%3B opt: 416%2C z-score: 500.9%2C E(): 1.4e-20%2C (39.8%25 identity in 206 aa overlap). gene gene2046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2045 SCO2046 SCO2046 SC4G6.15c SC4G6.15c 2194858 2196012 - integral membrane efflux protein SC4G6.15c%2C possible integral membrane efflux protein%2C len: 384aa%3B similar to many egs. TR:O31137 (EMBL:AF030344) TetV%2C tetracycline resistance determinant from Mycobacterium smegmatis (419 aa) fasta scores%3B opt: 446%2C z-score: 465.6%2C E(): 1.3e-18%2C (27.3%25 identity in 381 aa overlap) and TR:CAB41206 (EMBL:AL049661) integral membrane efflux protein from Streptomyces coelicolor (500 aa) fasta scores%3B opt: 416%2C z-score: 433.8%2C E(): 7.7e-17%2C (32.8%25 identity in 375 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene2047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2046 SCO2047 SCO2047 SC4G6.16c SC4G6.16c 2196122 2196709 - DNA-binding protein SC4G6.16c%2C possible DNA-binding protein%2C len: 195aa%3B contains helix-turn-helix motif (+3.18 SD) 37-58aa. gene gene2048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2047 SCO2048 SCO2048 SC4G6.17c SC4G6.17c 2196793 2197548 - imidazole glycerol phosphate synthase subunit HisF catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate%2C 5-aminoimidazol-4-carboxamideribonucleotide and glutamate%3B the HisF subunit acts as a cyclase gene gene2049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2048 SCO2049 SCO2049 SC4G6.18c SC4G6.18c 2197545 2197949 - hypothetical protein SC4G6.18c%2C conserved hypothetical protein%2C len: 134aa%3B previously sequenced therefore almost identical to SW:YHI2_STRCO. Also similar to many others eg. TR:O07205 (EMBL:Z96072) hypothetical protein from Mycobacterium tuberculosis (142 aa) fasta scores%3B opt: 225%2C z-score: 300.2%2C E(): 2.1e-09%2C (34.1%25 identity in 123 aa overlap). gene gene2050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2049 SCO2050 SCO2050 hisA hisA 2197966 2198688 - 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l-(5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate%3B involved in histidine and tryptophan biosynthesis gene gene2051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2050 SCO2051 SCO2051 hisH hisH 2198706 2199374 - imidazole glycerol phosphate synthase subunit HisH with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate%2C 5-aminoimidazol-4-carboxamide ribonucleotide%2C and glutamate in histidine biosynthesis%3B the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide gene gene2052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2051 SCO2052 SCO2052 hisB hisB 2199539 2200132 - imidazoleglycerol-phosphate dehydratase catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis gene gene2053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2052 SCO2053 SCO2053 hisC1 hisC1 2200129 2201238 - histidinol-phosphate aminotransferase catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis gene gene2054 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2053 SCO2054 SCO2054 hisD hisD 2201235 2202560 - histidinol dehydrogenase catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis%3B functions as a dimer gene gene2055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2054 SCO2055 SCO2055 SC4G6.24 SC4G6.24 2202760 2204337 + hypothetical protein SC4G6.24%2C unknown%2C len: 525 aa%3B previously sequenced but annotated as two seperate hypothetical CDSs TR:Q53930 and TR:Q53931 (EMBL:X64420)) suggesting a sequence error which lead to a frameshift. Amino acid and codon usage plots support a single CDS. Also similar to TR:O88013 (EMBL:AL031107) hypothetical protein from Streptomyces coelicolor (527 aa) fasta scores%3B opt: 593%2C z-score: 699.2%2C E(): 1.3e-31%2C (36.0%25 identity in 545 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene2056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2055 SCO2056 SCO2056 SC4G6.25 SC4G6.25 2204605 2205735 + hypothetical protein SC4G6.25%2C unknown%2C len: 376aa gene gene2057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2056 SCO2057 SCO2057 SC4G6.26 SC4G6.26 2205747 2206487 + hypothetical protein SC4G6.26%2C unknown%2C len: 246 aa%3B similar to TR:Q55701 (EMBL:D64000) hypothetical protein from Synechocystis sp. strain PCC6803 (214 aa) fasta scores%3B opt: 158%2C z-score: 192.8%2C E(): 0.0021%2C (32.6%25 identity in 224 aa overlap). Also some simliarity to the N-terminal region of many ATP-dependent proteases eg. SW:LON_ECOLI Lon protease from Escherichia coli (784 aa) fasta scores%3B opt: 152%2C z-score: 176.8%2C E(): 0.016%2C (24.6%25 identity in 228 aa overlap). gene gene2058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2057 SCO2058 SCO2058 SC4G6.27 SC4G6.27 2206501 2207010 + transcriptional regulator SC4G6.27%2C possible transcriptional regulatory protein%2C len: 169 aa%3B similar to many e.g. TR:Q51388 (EMBL:U49666) proposed regulatory protein from the glycerol metabolism cluster in Pseudomonas aeruginosa (156 aa) fasta scores%3B opt: 546%2C z-score: 627.8%2C E(): 1.2e-27%2C (59.7%25 identity in 154 aa overlap). Contains possible helix-turn-helix motif (+2.63 SD) 43-64 aa. Contains possible N-terminal region signal peptide sequence gene gene2059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2058 SCO2059 SCO2059 SC4G6.28c SC4G6.28c 2207142 2207858 - hypothetical protein SC4G6.28c%2C possible membrane protein%2C len: 238aa%3B Contains possible membrane spanning hydrophobic regions. gene gene2060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2059 SCO2060 SCO2060 SC4G6.29c SC4G6.29c 2207893 2208813 - integral membrane transport protein SC4G6.29c%2C possible integral membrane transport protein%2C len: 306aa%3B weakly similar to many eg. TR:CAB42664 (EMBL:AL049819) integral membrane protein from Streptomyces coelicolor (266 aa) fasta scores%3B opt: 163%2C z-score: 184.2%2C E(): 0.0061%2C (25.3%25 identity in 273 aa overlap). Contains possible membrane spanning hydrophobic regions. Location directly downstream of a possible ABC transport ATP-binding protein sueggsts a transport function. gene gene2061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2060 SCO2061 SCO2061 SC4G6.30c SC4G6.30c 2208825 2209799 - ABC transport ATP-binding subunit SC4G6.30c%2C possible ABC transport ATP-binding subunit%2C len: 324aa%3B similar to many eg. TR:Q53716 (EMBL:L06249) ATP-binding protein from Streptomyces antibioticus (325 aa) fasta scores%3B opt: 611%2C z-score: 658.7%2C E(): 2.3e-29%2C (39.4%25 identity in 310 aa overlap). Also similar to TR:CAB42771 (EMBL:AL049841) from Streptomyces coelicolor (315 aa) fasta scores%3B opt: 599%2C z-score: 646.2%2C E(): 1.1e-28%2C (40.9%25 identity in 291 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene2062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2061 SCO2062 SCO2062 SC4G6.31c SC4G6.31c 2209967 2211178 - hypothetical protein SC4G6.31c%2C unknown%2C len: 403aa gene gene2063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2062 SCO2063 SCO2063 SC4G6.32 SC4G6.32 2211403 2211570 + small hydrophilic protein SC4G6.32%2C possible small hydrophilic protein%2C len: 55 aa gene gene2064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2063 SCO2064 SCO2064 dnaE dnaE 2211637 2215176 - DNA polymerase III subunit alpha catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time%3B main replicative polymerase gene gene2065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2064 SCO2065 SCO2065 SC4G6.34 SC4G6.34 2215379 2216719 + hypothetical protein SC4G6.34%2C unknown%2C len: 446 aa%3B weakly similar to two other hypothetical proteins from Streptomyces coelicolor%3B TR:CAB45208 (EMBL:AL079308) (509 aa) fasta scores%3B opt: 382%2C z-score: 443.7%2C E(): 2.2e-17%2C (33.3%25 identity in 448 aa overlap) and TR:O86499 (EMBL:AL031232) (469 aa) fasta scores%3B opt: 222%2C z-score: 259.2%2C E(): 4.1e-07%2C (27.7%25 identity in 437 aa overlap) gene gene2066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2065 SCO2066 SCO2066 SC4G6.35 SC4G6.35 2216806 2217516 + hypothetical protein SC4G6.35%2C possible membrane protein%2C len: 236aa%3B Contains possible membrane spanning hydrophobic regions. gene gene2067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2066 SCO2067 SCO2067 SC4G6.36 SC4G6.36 2217614 2218414 + hypothetical protein SC4G6.36%2C membrane protein%2C len: 266 aa%3B weakly similar to TR:O69463 (EMBL:AL023635) hypothetical protein from Mycobacterium leprae (258 aa) fasta scores%3B opt: 250%2C z-score: 277.4%2C E(): 4e-08%2C (27.2%25 identity in 250 aa overlap) and similar to TR:Q9S2U7 (EMBL:AL096884) Streptomyces coelicolor integral membrane protein SC4G6.04c%2C 275 aa%3B fasta scores: opt: 519 Z-score: 568.5 E(): 4.9e-24%3B 34.470%25 identity in 264 aa overlap. Contains possible hydrophobic membrane spanning region gene gene2068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2067 SCO2068 SCO2068 SC4A10.01 SC4A10.01 2218545 2220200 + alkaline phosphatase SC4A10.01%2C hypothetical protein%2C partial CDS%2C len: >67 aa%3B unknown function%2C probable CDS suggested by GC frameplot and positional base preference. Continues in cosmid 4G6 as SC4G6.39~SC4G6.37%2C possible alkaline phosphatase%2C len: >517aa%3B similar to SW:PPBD_BACSU alkaline phosphatase D from Bacillus subtilis (556 aa) fasta scores%3B opt: 837%2C z-score: 915.3%2C E(): 0%2C (34.3%25 identity in 539 aa overlap). Contains possible N-terminal region signal sequence peptide gene gene2069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2068 SCO2069 SCO2069 SC4A10.02c SC4A10.02c 2220185 2220775 - hypothetical protein SC4A10.02c%2C hypothetical protein%2C len: 196 aa%3B similar to the plasmid borne TR:CAC48425 (EMBL:AL603642) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMB20022%2C 188 aa%3B fasta scores: opt: 485 Z-score: 576.0 E(): 1.9e-24%3B 45.198%25 identity in 177 aa overlap. Probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Annotated in cosmid 4G6 as SC4G6.38c gene gene2070 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2069 SCO2070 SCO2070 SC4A10.03 SC4A10.03 2220881 2222029 + hypothetical protein SC4A10.03%2C possible membrane protein%2C len: 382 aa%3B unknown function%2C shows weak similarity to parts of many hypothetical proteins e.g. SW:YB43_METJA (EMBL:U67556) Methanococcus jannaschii hypothetical protein (361 aa)%2C fasta scores%3B opt: 222 z-score: 255.3 E(): 6.7e-07%2C 24.8%25 identity in 306 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00924 UPF0003%2C Uncharacterized protein family UPF0003 gene gene2071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2070 SCO2071 SCO2071 SC4A10.04c SC4A10.04c 2222051 2223637 - Na+/H+ antiporter SC4A10.04c%2C possible Na+/H+ antiporter%2C len: 528 aa%3B shows weak similarity to the N-terminal portion of eukaryotic Na+/H+ antiporters e.g. SW:NAH3_RAT (EMBL:M85300) Rattus norvegicus sodium/hydrogen exchanger 3 (831 aa)%2C fasta scores%3B opt: 271 z-score: 293.1 E(): 5.3e-09%2C 25.8%25 identity in 481 aa overlap. Similar to many Na+/H+ antiporters e.g. SW:YU23_MYCTU (EMBL:Z77163) Mycobacterium tuberculosis Na(+)/H(+) exchanger (542 aa) (31.4%25 identity in 528 aa overlap). Shows weak similarity to SC66T3.14c (EMBL:AL079348) S.coelicolor probable Na(+)/H(+) antiporter (514 aa) (27.5%25 identity in 545 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00999 Na_H_Exchanger%2C Sodium/hydrogen exchanger family gene gene2072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2071 SCO2072 SCO2072 SC4A10.05c SC4A10.05c 2223726 2224208 - hypothetical protein SC4A10.05c%2C hypothetical protein%2C len: 160 aa%3B unknown function%2C shows weak similarity to hypothetical proteins from other eubacteria e.g. SW:YYBD_BACSU (EMBL:D26185) Bacillus subtilis hypothetical protein (147 aa)%2C fasta scores%3B opt: 199 z-score: 236.4 E(): 7.6e-06%2C 36.8%25 identity in 144 aa overlap. Shows weak similarity to SC5F7.12c (EMBL:AL096872) S.coelicolor possible acetyltransferase (169 aa) (37.7%25 identity in 114 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene2073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2072 SCO2073 SCO2073 SC4A10.06c SC4A10.06c 2224211 2225155 - ribosomal large subunit pseudouridine synthase SC4A10.06c%2C possible ribosomal large subunit pseudouridine synthase%2C len: 314 aa%3B similar to many e.g. SW:RLUC_ECOLI (EMBL:AE000209)%2C RluC%2C Escherichia coli ribosomal large subunit pseudouridine synthase C%2C fasta scores%3B opt: 415 z-score: 467.2 E(): 1.1e-18%2C 30.1%25 identity in 326 aa overlap and SW:RLUD_ECOLI (EMBL:U50134)%2C RluD%2C Escherichia coli ribosomal large subunit pseudouridine synthase D (326 aa) (37.1%25 identity in 315 aa overlap). Highly similar to hypothetical proteins from mycobacteria e.g. MLCB458.15 (EMBL:AL049478)%2C RluC%2C Mycobacterium leprae possible pseudouridine synthase (308 aa) (64.3%25 identity in 305 aa overlap). Contains Pfam matches to entry PF01479 S4%2C S4 domain and to entry PF00849 YABO%2C Hypothetical yabO/yceC/sfhB family gene gene2074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2073 SCO2074 SCO2074 lspA lspA 2225281 2225895 - lipoprotein signal peptidase lipoprotein signal peptidase%3B integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis gene gene2075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2074 SCO2075 SCO2075 SC4A10.08c SC4A10.08c 2225964 2226683 - DNA-binding protein SC4A10.08c%2C probable DNA-binding protein%2C len: 239 aa%3B the N-terminus is Lys- and Ala-rich%2C containing 13 degenerate AAKK(S)(P/T) repeats and is similar to histone-like proteins e.g. SW:KARP_CHLTR (EMBL:M86605)%2C KarP%2C Chlamydia trachomatis developmentally regulated gene (207 aa)%2C fasta scores%3B opt: 245 z-score: 253.5 E(): 8.5e-07%2C 44.7%25 identity in 114 aa overlap. This region is also similar to a repeat in TR:O86537 (EMBL:AL031124) S.coelicolor histone-like DNA binding protein (218 aa) (51.4%25 identity in 72 aa overlap). The C-terminus is similar to SW:DKSA_ECOLI (EMBL:M34945)%2C DskA%2C Escherichia coli DnaK suppressor protein (151 aa) (28.8%25 identity in 125 aa overlap)%2C a dosage-dependent suppressor of dnaK deletion mutants. Contains probable coiled-coil from 123 to 159 (37 residues) (Max score: 1.709%2C probability 1.00). Contains Pfam match to entry PF01258 zf_dskA_traR%2C Prokaryotic dksA/traR C4-type zinc finger and PS01102 Prokaryotic dksA/traR C4-type zinc finger gene gene2076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2075 SCO2076 SCO2076 ileS ileS 2227237 2230380 + isoleucyl-tRNA synthetase IleRS%3B catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile)%3B since isoleucine and other amino acids such as valine are similar%2C there are additional editing function in this enzyme%3B one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile)%3B there are two active sites%2C one for aminoacylation and one for editing%3B class-I aminoacyl-tRNA synthetase family type 2 subfamily%3B some organisms carry two different copies of this enzyme%3B in some organisms%2C the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) gene gene2077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2076 SCO2077 SCO2077 SC4A10.10c SC4A10.10c 2230582 2231778 - hypothetical protein SC4A10.10c%2C hypothetical protein%2C len: 398 aa%3B unknown function%2C probable Gln-%2C Met- and Pro-rich CDS suggested by GC frame plot%2C positional base preference and amino acid composition. Contains probable coiled-coils from 23 to 68 (46 residues) (Max score: 1.868%2C probability 1.00) and from 217 to 294 (78 residues) (Max score: 1.445%2C probability 0.86) gene gene2078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2077 SCO2078 SCO2078 SC4A10.11c SC4A10.11c 2231834 2232118 - hypothetical protein SC4A10.11c%2C membrane protein%2C len: 94 aa%3B unknown function%2C similar to hypothetical proteins e.g. TR:O06230 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical protein (96 aa)%2C fasta scores%3B opt: 262 z-score: 367.1 E(): 4e-13%2C 41.9%25 identity in 86 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2078 SCO2079 SCO2079 SC4A10.12c SC4A10.12c 2232200 2232841 - hypothetical protein SC4A10.12c%2C conserved hypothetical protein%2C len: 213 aa%3B unknown function%2C similar to hypothetical proteins e.g. TR:O06229 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical protein (241 aa)%2C fasta scores%3B opt: 441 z-score: 479.6 E(): 2.2e-19%2C 40.8%25 identity in 218 aa overlap. The N-terminus is Asp- and Glu-rich gene gene2080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2079 SCO2080 SCO2080 SC4A10.13c SC4A10.13c 2232970 2233689 - hypothetical protein SC4A10.13c%2C conserved hypothetical protein%2C len: 239 aa%3B unknown function%2C similar to many hypothetical proteins e.g. SW:YPT5_PSEAE (EMBL:M55524) Pseudomonas aeruginosa hypothetical protein (230 aa)%2C fasta scores%3B opt: 464 z-score: 546.4 E(): 4.1e-23%2C 39.7%25 identity in 229 aa overlap. Contains Pfam match to entry PF01168 UPF0001%2C Uncharacterized protein family UPF0001 and PS01211 Uncharacterized protein family UPF0001 signature gene gene2081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2080 SCO2081 SCO2081 SC4A10.14c SC4A10.14c 2233696 2234424 - hypothetical protein SC4A10.14c%2C conserved hypothetical protein%2C len: 242 aa%3B unknown function%2C similar to many hypothetical proteins e.g. SW:YFIH_STRGR (EMBL:U07344) Streptomyces griseus hypothetical protein (246 aa)%2C fasta scores%3B opt: 1246 z-score: 1349.0 E(): 0 76.3%25 identity in 245 aa overlap and SW:YFIH_ECOLI (EMBL:U50134)%2C YfiH%2C Escherichia coli hypothetical protein (243 aa) (38.5%25 identity in 247 aa overlap) gene gene2082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2081 SCO2082 SCO2082 ftsZ ftsZ 2234421 2235620 - cell division protein FtsZ GTPase%3B similar structure to tubulin%3B forms ring-shaped polymers at the site of cell division%3B other proteins such as FtsA%2C ZipA%2C and ZapA%2C interact with and regulate FtsZ function gene gene2083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2082 SCO2083 SCO2083 ftsQ ftsQ 2235909 2236703 - sporulation protein SC4A10.16c%2C ftsQ%2C sporulation protein%2C len: 264 aa%3B previously sequenced as SW:FTSQ_STRCO (EMBL:U10879)%2C ftsQ%2C Streptomyces coelicolor protein required for efficient sporulation%2C but not growth and viability (264 aa) and identical that sequence. Contains a hydrophobic%2C possible membrane-spanning region gene gene2084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2083 SCO2084 SCO2084 murG murG 2236729 2237823 - UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase%3B involved in cell wall formation%3B inner membrane-associated%3B last step of peptidoglycan synthesis gene gene2085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2084 SCO2085 SCO2085 ftsW ftsW 2237830 2239200 - cell division protein SC4A10.18c%2C ftsW%2C probable cell division protein%2C len%3B 456 aa%3B previously sequenced as TR:Q9ZBA6 (EMBL:U10879)%2C ftsW%2C Streptomyces coelicolor ftsW protein (456 aa) and identical to that sequence. Similar to many members of the ftsW/rodA/spoVE family e.g. SW:SP5E_BACSU (EMBL:X51419)%2C spoVE%2C Bacillus subtilis stage V sporulation protein (366 aa)%2C fasta scores%3B opt: 745 z-score: 788.4 E(): 0%2C 36.9%25 identity in 350 aa overlap. Shows similarity to SC6G9.31 (EMBL:AL079356) S.coelicolor probable integral membrane cell-cycle protein (446 aa) (30.0%25 identity in 416 aa overlap) and SCH69.16 (EMBL:AL079308) S.coelicolor probable FtsW/RodA/SpoVE family cell cycle protein (479 aa) (28.6%25 identity in 385 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE%2C Cell cycle protein and PS00428 Cell cycle proteins ftsW/rodA/spoVE signature gene gene2086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2085 SCO2086 SCO2086 murD murD 2239278 2240693 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase UDP-N-acetylmuramoylalanine--D-glutamate ligase%3B involved in peptidoglycan biosynthesis%3B cytoplasmic%3B catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation gene gene2087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2086 SCO2087 SCO2087 mraY mraY 2240702 2241793 - phospho-N-acetylmuramoyl-pentapeptide-transferase First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan gene gene2088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2087 SCO2088 SCO2088 murF murF 2241793 2243208 - UDP-N-acetylmuramoylalanyl-D-glutamyl-2%2C6-diaminopimelate- D-alanyl-alanyl ligase SC4A10.21c%2C murF%2C probable UDP-N-acetylmuramoylalanyl-D-glutamyl- 2%2C6-diaminopimelate- D-alanyl-alanyl ligase%2C len: 471 aa%3B similar to many e.g. SW:MURF_ECOLI (EMBL:X15432)%2C Mra%2C MurF%2C Escherichia coli UDP-N-acetylmuramoylalanyl-D-glutamyl- 2%2C6-diaminopimelate- D-alanyl-alanyl ligase (452 aa)%2C fasta scores%3B opt: 774 z-score: 866.3 E(): 0%2C 36.1%25 identity in 471 aa overlap. Also similar to SW:MURF_STRTO (EMBL:U82965)%2C MurF%2C MurX%2C Streptomyces toyocaensis probable UDP-N-acetylmuramoylalanyl-D-glutamyl- 2%2C6-diaminopimelate- D-alanyl-alanyl ligase (443 aa) (50.4%25 identity in 464 aa overlap). Shows weak similarity to others from S.coelicolor e.g. SC9B1.07 (EMBL:AL049727) S.coelicolor possible UDP-N-acetylmuramoyl-L-alanine ligase (462 aa) (24.1%25 identity in 464 aa overlap). Contains Pfam match to entry PF01225 Mur_ligase%2C Mur ligase family gene gene2089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2088 SCO2089 SCO2089 murE murE 2243269 2244789 - UDP-N-acetylmuramoylalanyl-D-glutamate--2%2C6-diaminopimelate ligase involved in cell wall formation%3B peptidoglycan synthesis%3B cytoplasmic enzyme%3B catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate gene gene2090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2089 SCO2090 SCO2090 ftsI ftsI 2244997 2246961 - cell division protein SC4A10.23c%2C ftsI%2C cell division protein%2C len: 654 aa%3B previously sequenced as TR:Q9Z5V7 (EMBL:AF123319)%2C FtsI%2C Streptomyces coelicolor cell division protein (651 aa) and identical to that sequence%2C but with a different start codon. C-terminal end shares weak similarity with others from S.coelicolor e.g. SC6G9.32 (EMBL:AL079356) S.coelicolor possible penicillin-binding protein (485 aa) (29.3%25 identity in 447 aa overlap). Contains a hydrophobic%2C possible membrane-spanning region. Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and two PS00017 ATP/GTP-binding site motif A (P-loop) gene gene2091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2090 SCO2091 SCO2091 SC4A10.24c SC4A10.24c 2246958 2247578 - hypothetical protein SC4A10.24c%2C possible membrane protein%2C len: 206 aa%3B unknown function%2C previously partially sequenced as TR:Q9Z5V8 (EMBL:AF123319) Streptomyces coelicolor hypothetical protein (fragment) (163 aa) and identical to that sequence. Similar to a central region of mycobacterial hypothetical proteins e.g. TR:O06213 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical protein (384 aa)%2C fasta scores%3B opt: 282 z-score: 255.8 E(): 6.8e-07%2C 36.2%25 identity in 224 aa overlap. Contains a hydrophobic%2C possible membrane-spanning region and probable coiled-coil from 74 to 109 (36 residues) (Max score: 1.684%2C probability 1.00) gene gene2092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2091 SCO2092 SCO2092 mraW mraW 2247685 2248617 - S-adenosyl-methyltransferase MraW SC4A10.25c%2C conserved hypothetical protein%2C len: 310 aa%3B unknown function%2C similar to many hypothetical proteins e.g. TR:O06212 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical protein (396 aa)%2C fasta scores%3B opt: 1037 z-score: 1165.6 E(): 0%2C 53.7%25 identity in 313 aa overlap%2C which is longer at the N-terminus. The majority of possible homologues are 300-320 aa in length gene gene2093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2092 SCO2093 SCO2093 SC4A10.26 SC4A10.26 2249114 2249617 + hypothetical protein SC4A10.26%2C conserved hypothetical protein%2C len: 167 aa%3B unknown function%2C similar to other hypothetical proteins e.g. SW:Y023_MYCTU (EMBL:Z73419) Mycobacterium tuberculosis hypothetical protein (163 aa)%2C fasta scores%3B opt: 567 z-score: 691.9 E(): 3.2e-31%2C 53.4%25 identity in 163 aa overlap. Very weak similarity to the C-terminus of many carbonic anhydrases e.g. TR:P93109 (EMBL:U80805) Chlamydomonas reinhardtii beta-carbonic anhydrase (267 aa) (24.3%25 identity in 181 aa overlap) gene gene2094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2093 SCO2094 SCO2094 SC4A10.27 SC4A10.27 2249934 2250947 + regulatory protein SC4A10.27%2C possible regulatory protein%2C len: 337 aa%3B similar to many e.g. SW:MOXR_PARDE (EMBL:M57684)%2C MoxR%2C Paracoccus denitrificans protein probably involved in the regulation of methanol dehydrogenase synthesis (339 aa)%2C fasta scores%3B opt: 189 z-score:216.0 E(): 7.6e-05%2C 31.55%25 identity in 336 aa overlap. Similar to many hypothetical proteins e.g. TM1132 (EMBL:AE001771) Thermotoga maritima MoxR protein (305 aa) (52.1%25 identity in 303 aa overlap). Similar to TR:Q9Z538 (EMBL:AL035212) S.coelicolor possible regulatory protein (332 aa) (45.8%25 identity in 312 aa overlap) gene gene2095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2094 SCO2095 SCO2095 SC4A10.28 SC4A10.28 2250944 2252308 + hypothetical protein SC4A10.28%2C possible membrane protein%2C len: 454 aa%3B unknown function%2C similar to parts of bacterial hypothetical proteins e.g. TR:P74479 (EMBL:D90915) Synechocystis sp hypothetical protein (406 aa)%2C fasta scores%3B opt: 266 z-score: 307.9 E(): 8e-10%2C 30.4%25 identity in 253 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions near the N-terminus gene gene2096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2095 SCO2096 SCO2096 SC4A10.29 SC4A10.29 2252305 2254698 + hypothetical protein SC4A10.29%2C possible membrane protein%2C len: 797 aa%3B unknown function%2C shows weak similarity to parts of other bacterial hypothetical proteins e.g. TR:P94476 (EMBL:U51115)%2C yebA%2C Bacillus subtilis hypothetical protein (655 aa)%2C fasta scores%3B opt: 335 z-score: 330.0 E(): 4.7e-11%2C 30.4%25 identity in 263 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions in the N-terminus gene gene2097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2096 SCO2097 SCO2097 SC4A10.30c SC4A10.30c 2254850 2255257 - hypothetical protein SC4A10.30c%2C possible membrane protein%2C len: 135 aa%3B unknown function%2C similar to mycobacterial hypothetical proteins TR:O53503 (EMBL:AL021957) Mycobacterium tuberculosis (134 aa)%2C fasta scores%3B opt: 349 z-score: 414.6 E(): 9e-16%2C 44.1%25 identity in 136 aa overlap and its homologue in Mycobacterium leprae TR:O69562 (EMBL:AL022602) Mycobacterium leprae hypothetical protein (134 aa) (42.6%25 identity in 136 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene2098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2097 SCO2098 SCO2098 SC4A10.31c SC4A10.31c 2255534 2256349 - methyltransferase SC4A10.31c%2C possible methyltransferase%2C len: 271 aa%3B shows weak similarity to SW:SMTA_ECOLI (EMBL:D26440)%2C SmtA%2C Escherichia coli S-adenosylmethionine-dependent methyltransferase (261 aa)%2C fasta scores%3B opt: 311 z-score: 330.3 E(): 4.5e-11%2C 32.0%25 identity in 250 aa overlap and to SC5F7.31 (EMBL:AL096872) S.coelicolor possible methyltransferase (233 aa) (34.3%25 identity in 236 aa overlap) gene gene2099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2098 SCO2099 SCO2099 SC4A10.32 SC4A10.32 2256540 2257046 + hypothetical protein SC4A10.32%2C hypothetical protein%2C len: 168 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene2100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2099 SCO2100 SCO2100 SC4A10.33 SC4A10.33 2257287 2257916 + transcriptional regulator SC4A10.33%2C probable transcriptional regulator%2C len: 209 aa%3B shows weak similarity to many hypothetical proteins e.g. TR:O53641 (EMBL:AL021927) Mycobacterium tuberculosis hypothetical protein (214 aa)%2C fasta scores%3B opt: 224 z-score: 282.1 E(): 2.2e-08%2C 28.8%25 identity in 208 aa overlap and to SCI30A.20c (EMBL:AL096811) S.coelicolor possible transcriptional regulator (215 aa) (31.6%25 identity in 190 aa overlap). Contains probable helix-turn-helix motif at aa 38-59 (Score 1454%2C +4.14 SD) and Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene2101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2100 SCO2101 SCO2101 SC4A10.34 SC4A10.34 2258402 2259922 + carotenoid dehydrogenase SC4A10.34%2C probable carotenoid dehydrogenase ( hypothetical protein)%2C len: 506 aa%3B similar to many bacterial and fungal carotenoid dehydrogenases e.g. SW:CRTD_RHOSH (EMBL:X63204) CrtD%2C Rhodobacter sphaeroides methoxyneurosporene dehydrogenase (495 aa)%2C fasta scores%3B opt: 470 z-score: 505.2 E(): 8.1e-21%2C 29.2%25 identity in 506 aa overlap. Shows very weak similarity to TR:Q9ZBG4 (EMBL:AL035206) S. coelicolor possible dehydrogenase (472 aa) (28.1%25 identity in 523 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene2102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2101 SCO2102 SCO2102 SC4A10.35c SC4A10.35c 2259944 2260936 - hypothetical protein SC4A10.35c%2C possible membrane protein%2C len: 330 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. The C-terminal half is Gln-rich. Contains hydrophobic%2C possible membrane-spanning regions in the N-terminus gene gene2103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2102 SCO2103 SCO2103 metF metF 2260993 2261916 - 5%2C10-methylenetetrahydrofolate reductase SC4A10.36c%2C metF%2C 5%2C10-methylenetetrahydrofolate reductase%2C len: 307 aa%3B identical to SW:METF_STRLI (EMBL:AJ001630)%2C MetF%2C Streptomyces lividans 5%2C10-methylenetetrahydrofolate reductase (307 aa)%2C apart from substitution of Arg41 for Lys41 in S.coelicolor%2C fasta scores%3B opt: 2015 z-score: 2364.3 E(): 0%2C 99.7%25 identity in 307 aa overlap gene gene2104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2103 SCO2104 SCO2104 thiE thiE 2262055 2262726 - thiamine-phosphate pyrophosphorylase Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate gene gene2105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2104 SCO2105 SCO2105 SC2C1A.01c SC2C1A.01c 2262881 2263246 - transcriptional regulator SC2C1A.01c%2C possible transcriptional regulatory protein%2C partial CDS%2C len: > 57 aa. Similar to Mycobacterium tuberculosis TR:O53509 (EMBL:AL021957) hypothetical protein (146 aa)%2C fasta scores opt: 137 z-score: 204.5 E(): 0.00048 42.3%25 identity in 71 aa overlap. Overlaps and extends into CDS SC4A10.38c on the adjoining cosmid. Contains a helix-turn-helix motif situated between residues 17..38 (+4.08 SD).~SC4A10.38c%2C conserved hypothetical protein%2C partial CDS%2C len: >86 aa%3B similar to mycobacterial hypothetical proteins TR:O53509 (EMBL:AL021957) Mycobacterium tuberculosis hypothetical protein (146 aa)%2C fasta scores%3B opt: 198 z-score: 273.9 E(): 6.2e-08%2C 43.9%25 identity in 98 aa overlap and TR:O69567 (EMBL:AL022602) Mycobacterium leprae possible transcriptional regulator (134 aa) (44.8%25 identity in 96 aa overlap) gene gene2106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2105 SCO2106 SCO2106 SC2C1A.02c SC2C1A.02c 2263288 2264511 - oxidoreductase SC2C1A.02c%2C possible oxidoreductase%2C len: 407 aa. Highly similar to several reductases including: Rhodococcus sp. (strain NI86/21) SW:THCD_RHOSN(EMBL:U17130) rhodocoxin reductase (EC 1.18.1.-) (426 aa)%2C fasta scores opt: 792 z-score: 833.9 E():0 36.9%25 identity in 412 aa overlap and Sphingomonas sp. TR:O65946(EMBL:AJ002606) reductase%2C RedA2%2C protein (409 aa)%2C fasta scores opt:794 z-score: 836.2 E():0 40.1%25 identity in 409 aa overlap gene gene2107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2106 SCO2107 SCO2107 SC2C1A.03 SC2C1A.03 2264828 2266033 + oxidoreductase SC6E10.01%2C possible oxidoreductase%2C partial CDS%2C len: >375 aa%3B similar to TR:O85228 (EMBL:AF053760)%2C HcnC%2C Pseudomonas fluorescens hydrogen cyanide synthase (417 aa)%2C fasta scores%3B opt: 511 z-score: 564.8 E(): 3.9e-24%2C 30.7%25 identity in 348 aa overlap%2C although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins~SC2C1A.03%2C possible oxidoreductase%2C partial CDS%2C len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa)%2C fasta scores opt: 111 z-score: 145.4 E(): 0.94 54.3%25 identity in 35 aa overlap. Overlaps and extends into CDS SC6E10.01 on the adjoining cosmid gene gene2108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2107 SCO2108 SCO2108 SC6E10.02 SC6E10.02 2266030 2266230 + hypothetical protein SC6E10.02%2C conserved hypothetical protein%2C len: 66 aa%3B unknown function%2C similar to e.g. SW:THIS_ECOLI (EMBL:M88701)%2C ThiS%2C ThiG1%2C Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa)%2C fasta scores%3B opt: 138 z-score: 203.8 E(): 0.0005%2C 30.3%25 identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7%25 identity in 68 aa overlap) gene gene2109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2108 SCO2109 SCO2109 thiG thiG 2266233 2267027 + thiazole synthase functions in thiamine (vitamin B1) biosynthesis%3B in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate gene gene2110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2109 SCO2110 SCO2110 pkaF pkaF 2267186 2269189 + Ser/Thr protein kinase SC6E10.04%2C pkaF%2C probable eukaryotic-type Ser/Thr protein kinase%2C len: 667 aa%3B previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence%2C but with a different start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857)%2C Pkn2%2C Myxococcus xanthus Ser/Thr protein kinase involved in regulation of beta-lactamase secretion (830 aa)%2C fasta scores%3B opt: 564 z-score: 531.4 E(): 2.8e-22%2C 35.5%25 identity in 366 aa overlap. Similar to many hypothetical protein Ser/Thr protein kinases from mycobacteria e.g. TR:O53510 (EMBL:AL021957) Mycobacterium tuberculosis (399 aa) (43.4%25 identity in 394 aa overlap). Similar to others from S.coelicolor e.g. SCH69.18 (EMBL:AL079308) S.coelicolor possible Ser/Thr protein kinase (673 aa) (34.7%25 identity in 622 aa overlap). Alternative start codons are present at codons 3 and 11. Contains probable coiled-coil from 543 to 576 (34 residues) (Max score: 1.485%2C probability 0.93). Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and PS00108 Ser/Thr protein kinases active-site signature and possible hydrophobic membrane spanning region gene gene2111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2110 SCO2111 SCO2111 SC6E10.05 SC6E10.05 2269374 2270258 + endonuclease SC6E10.05%2C probable endonuclease%2C len: 294 aa%3B similar to many DNA-repair endonucleases e.g. SW:END4_ECOLI (EMBL:M22591)%2C nfo%2C Escherichia coli endonuclease IV (285 aa)%2C fasta scores%3B opt: 482 z-score: 516.5 E(): 1.9e-21%2C 33.3%25 identity in 279 aa overlap and SW:APN1_YEAST (EMBL:M33667)%2C apn1%2C Saccharomyces cerevisiae DNA-(apurinic or apyrimidinic site) lyase (366 aa) (28.4%25 identity in 289 aa overlap). Contains Pfam match to entry PF01261 AP_endonuclease2%2C AP endonuclease family 2%2C PS00730 AP endonucleases family 2 signature 2 and PS00731 AP endonucleases family 2 signature 3 gene gene2112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2111 SCO2112 SCO2112 SC6E10.06c SC6E10.06c 2270305 2270952 - hypothetical protein SC6E10.06c%2C hypothetical protein%2C len: 215 aa%3B unknown function%2C similar to hypothetical proteins e.g. TR:O32103 (EMBL:Z99120) Bacillus subtilis hypothetical protein (198 aa)%2C fasta scores%3B opt: 522 z-score: 625.8 E(): 1.5e-27%2C 40.6%25 identity in 192 aa overlap. Shares a short sequence motif from aa 150-160 with many oxidoreductases (sulfite oxidases and nitrate reductases). An alternative start codon is present at codon 5 gene gene2113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2112 SCO2113 SCO2113 bfr bfr 2271144 2271647 + bacterioferritin SC6E10.07%2C bfr%2C probable bacterioferritin%2C len: 167 aa%3B highly similar to SW:BFR_MYCAV (EMBL:X76906) Bfr%2C Mycobacterium avium bacterioferritin (159 aa)%2C fasta scores%3B opt: 672 z-score: 815.6 E(): 0%2C 63.6%25 identity in 162 aa overlap. Contains Pfam match to entry PF01334 Bacteriofer%2C Bacterioferritin gene gene2114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2113 SCO2114 SCO2114 SC6E10.08c SC6E10.08c 2271664 2271915 - hypothetical protein SC6E10.08c%2C hypothetical protein%2C len: 83 aa%3B unknown function%2C similar to part of many nitrate or nitrite reductases e.g. SW:NIR_EMENI (EMBL:M58289)%2C NiiA%2C Emericella nidulans nitrite reductase (1104 aa)%2C fasta scores%3B opt: 137 z-score: 178.6 E(): 0.013%2C 38.0%25 identity in 50 aa overlap gene gene2115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2114 SCO2115 SCO2115 aroH aroH 2272073 2273425 - 2-dehydro-3-deoxyphosphoheptonate aldolase SC6E10.09c%2C aroH%2C probable 2-dehydro-3-deoxyphosphoheptonate aldolase%2C len: 450 aa%3B highly similar to many%2C especially those from plants e.g. SW:AROF_ARATH (EMBL:M74819)%2C Dhs1%2C Arabidopsis thaliana phospho-2-dehydro-3-deoxyheptonate aldolase 1 precursor (525 aa)%2C fasta scores%3B opt: 1633 z-score: 1839.4 E(): 0%2C 53.8%25 identity in 437 aa overlap. The N-terminus is similar (but not identical) to the SW:AROF_STRCO%2C AroH%2C Streptomyces coelicolor 2-dehydro-3-deoxyphosphoheptonate aldolase N-terminal sequence determined from purified protein (TVNAKTSPSA GNTDDPLQAP S). Similar to TR:O52308 (EMBL:AF035756) Streptomyces sp. 2-dehydro-3-deoxyphosphoheptonate aldolase (fragment) (448 aa) (90.4%25 identity in 448 aa overlap). Also similar to TR:Q9Z4X1 (EMBL:AL035654)%2C Aro%2C S.coelicolor probable 2-dehydro-3-deoxyheptonate aldolase (484 aa) (53.6%25 identity in 440 aa overlap). An alternative start codon is present at codon 3. Contains Pfam match to entry PF01474 DAHP_synth_2%2C Class-II DAHP synthetase family gene gene2116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2115 SCO2116 SCO2116 SC6E10.10 SC6E10.10 2273596 2276427 + hypothetical protein SC6E10.10%2C possible hypothetical protein%2C len: 943 aa%3B unknown function%2C similar in parts to bacterial AmpD (amidase) proteins e.g. TR:Q46959 (EMBL:U40805)%2C AmpD%2C Enterobacter cloacae anhydro-N-acetylmuramyl-tripeptide amidase (187 aa)%2C fasta scores%3B opt: 208 z-score: 224.7 E(): 3.4e-05%2C 37.4%25 identity in 123 aa overlap. Similar to parts of others from S.coelicolor e.g. SCH35.49C (EMBL:AL078610) S.coelicolor hypothetical protein (410 aa) (37.7%25 identity in 252 aa overlap). Contains possible N-terminal signal sequence. The C-terminus contains 5x degenerate 50 aa repeats gene gene2117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2116 SCO2117 SCO2117 SC6E10.11 SC6E10.11 2276703 2278607 + anthranilate synthase SC6E10.11%2C trpE1%2C probable anthranilate synthase%2C len: 634 aa%3B highly similar to many anthranilate synthases e.g. TR:O30589 (EMBL:AF012627)%2C TrpE%2C Streptomyces venezuelae anthranilate synthase (623 aa)%2C fasta scores%3B opt: 3108 z-score: 3257.7 E(): 0%2C 80.0%25 identity in 620 aa overlap. Anthranilate synthases may have one or two components. This protein is similar at the C-terminus to TR:Q9Z4W8 (EMBL:AL035654)%2C TrpG%2C S.coelicolor probable anthranilate synthase component II (200 aa) (32.7%25 identity in 202 aa overlap) and centrally to TR:Q9Z4W7 (EMBL:AL035654)%2C trpE2%2C S.coelicolor probable anthranilate synthase component I (511 aa) (30.6%25 identity in 301 aa overlap) which appear to constitute a two-component type enzyme. Contains two Pfam matches to entry PF00425 chorismate_bind%2C chorismate binding enzyme and Pfam match to entry PF00117 GATase%2C Glutamine amidotransferase class-I gene gene2118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2117 SCO2118 SCO2118 dldh2 dldh2 2278559 2279554 - D-lactate dehydrogenase Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate%2C alpha-ketoglutarate%2C and to a much lower extent%2C KHTCA%2C but not pyruvate. Involved in the biosynthes gene gene2119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2118 SCO2119 SCO2119 pfkA pfkA 2279638 2280666 - 6-phosphofructokinase catalyzes the formation of D-fructose 1%2C6-bisphosphate from D-fructose 6-phosphate in glycolysis gene gene2120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2119 SCO2120 SCO2120 SC6E10.14c SC6E10.14c 2280718 2281365 - two-component system regulator SC6E10.14c%2C probable two-component system regulator%2C len: 215 aa%3B similar to many e.g. SW:DEGU_BACBR (EMBL:M21658)%2C DegU%2C Bacillus brevis transcriptional regulatory protein for the production of extracellular proteases (236 aa)%2C fasta scores%3B opt: 443 z-score: 510.2 E(): 4.3e-21%2C 36.5%25 identity in 219 aa overlap. Similar to others from S.coelicolor e.g. SCH10.18C (EMBL:AL049754) S.coelicolor probable two-component system regulator (228 aa) (37.9%25 identity in 214 aa overlap). Contains probable helix-turn-helix motif at aa 169-190 (Score 1764%2C +5.19 SD). Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain and to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature gene gene2121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2120 SCO2121 SCO2121 SC6E10.15c SC6E10.15c 2281433 2282674 - two-component system sensor kinase SC6E10.15c%2C possible two-component system sensor kinase%2C len: 413 aa%3B similar to many e.g. SW:DEGS_BACBR (EMBL:L15444)%2C DegS%2C Bacillus brevis sensor protein (386 aa)%2C fasta scores%3B opt: 174 z-score: 193.4 E(): 0.0019%2C 23.4%25 identity in 278 aa overlap. The N-terminal approx. 100 aa are different from many of the homologues. Similar to others from S.coelicolor e.g. SCE126.08C (EMBL:AL049630) S.coelicolor possible two component sensor kinase (401 aa) (26.6%25 identity in 323 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions in the N-terminal half gene gene2122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2121 SCO2122 SCO2122 SC6E10.16c SC6E10.16c 2282715 2283503 - hypothetical protein SC6E10.16c%2C conserved hypothetical protein%2C len: 262 aa%3B unknown function%2C similar to part of TR:O33970 (EMBL:U80063) Streptomyces cinnamoneus hypothetical protein (199 aa)%2C fasta scores%3B opt: 827 z-score: 903.5 E(): 0%2C 61.9%25 identity in 202 aa overlap and to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. TR:O69572 (EMBL:AL022602) Mycobacterium leprae hypothetical protein (244 aa) (54.0%25 identity in 215 aa overlap). Similar to others from S.coelicolor e.g. TR:Q9ZBS1 (EMBL:AL034447) S.coelicolor possible acyltransferase (264 aa) (33.2%25 identity in 250 aa overlap). C-terminus contains 5x slightly degenerate KAAK(A/N)(D/E) repeats. Contains probable coiled-coil from 214 to 255 (42 residues) (Max score: 1.475%2C probability 0.92) gene gene2123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2122 SCO2123 SCO2123 SC6E10.17 SC6E10.17 2283639 2284442 + esterase/lipase SC6E10.17%2C possible esterase/lipase%2C len: 267 aa%3B similar to esterases e.g. SW:EST_BACST (EMBL:D12681)%2C Est%2C Bacillus stearothermophilus carboxylesterase precursor (247 aa)%2C fasta scores%3B opt: 333 z-score: 387.6 E(): 2.9e-14%2C 32.7%25 identity in 251 aa overlap gene gene2124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2123 SCO2124 SCO2124 SC6E10.18 SC6E10.18 2284435 2285052 + hypothetical protein SC6E10.18%2C membrane protein%2C len: 205 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. The amino acid composition of this CDS is unusual%2C being Pro-rich and having a very acidic N-terminus. Contains probable coiled-coil from 1 to 29 (29 residues) (Max score: 1.455%2C probability 0.88). Contains possible hydrophobic membrane spanning regions gene gene2125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2124 SCO2125 SCO2125 SC6E10.19c SC6E10.19c 2285077 2285838 - hypothetical protein SC6E10.19c%2C hypothetical protein%2C len: 362 aa%3B unknown function%2C weak similarity to Y63D3A.4 (EMBL:AL032652) Caenorhabditis elegans hypothetical protein (362 aa)%2C fasta scores%3B opt: 172 z-score: 209.3 E(): 0.00025%2C 28.7%25 identity in 181 aa overlap gene gene2126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2125 SCO2126 SCO2126 glk glk 2285983 2286936 - glucokinase SC6E10.20c%2C glk%2C glucokinase%2C len: 317 aa%3B previously sequenced as SW:GLK_STRCO (EMBL:X65932)%2C Glk%2C Streptomyces coelicolor glucokinase (317 aa)%2C identical to this sequence. Similar to other ROK-family proteins from S.coelicolor e.g. TR:O69941 (EMBL:AL023862) S. coelicolor hypothetical ROK family protein (403 aa) (34.7%25 identity in 317 aa overlap). Pfam match to entry PF00480 ROK%2C ROK family and PS01125 ROK family signature gene gene2127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2126 SCO2127 SCO2127 SC6E10.21c SC6E10.21c 2286991 2287566 - hypothetical protein SC6E10.21c%2C hypothetical protein%2C len: 191 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Previously sequenced as SW:YGL2_STRCO (EMBL:X65932) Streptomyces coelicolor hypothetical protein (191 aa)%2C identical to this sequence gene gene2128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2127 SCO2128 SCO2128 SC6E10.22c SC6E10.22c 2287637 2288911 - hypothetical protein SC6G10.01c%2C partial CDS%2C unknown%2C len: >40aa%3B~SC6E10.22c%2C hypothetical protein%2C len: 390 aa%3B unknown function%2C similar to the N-terminal half of anion-transporter ATPases e.g. TR:O50593 (EMBL:AB004659)%2C arsA%2C Acidiphilium multivorum plasmid pKW301 arsenite activated ATPase of translocating ATPase (583 aa)%2C fasta scores%3B opt: 190 z-score: 208.0 E(): 0.00029%2C 27.3%25 identity in 267 aa overlap. Previously partially sequenced as SW:YGL1_STRCO (EMBL:X65932) Streptomyces coelicolor hypothetical protein (341 aa)%2C identical to this sequence gene gene2129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2128 SCO2129 SCO2129 SC6G10.02c SC6G10.02c 2289023 2289457 - hypothetical protein SC6G10.02c%2C hypothetical protein%2C len: 144 aa%3B similar to hypothetical proteins from Mycobacterium eg. TR:O53519 (EMBL:AL021957) hypothetical protein from Mycobacterium tuberculosis (144 aa) fasta scores%3B opt: 479%2C z-score: 620.2%2C E(): 3.1e-27%2C (49.0%25 identity in 143 aa overlap) gene gene2130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2129 SCO2130 SCO2130 SC6G10.03c SC6G10.03c 2289595 2290392 - hypothetical protein SC6G10.03c%2C hypothetical protein%2C len: 265 aa%3B weak similarity to many eg. TR:P95860 (EMBL:Y08256) Sulfolobus solfataricus hypothetical protein ORF CO6013 (309 aa) fasta scores%3B opt: 152%2C z-score: 186.9%2C E(): 0.0041%2C (24.8%25 identity in 270 aa overlap). gene gene2131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2130 SCO2131 SCO2131 SC6G10.04 SC6G10.04 2290703 2292499 + long chain fatty acid CoA ligase SC6G10.04%2C probable long chain fatty acid CoA ligase%2C len: 598 aa%3B similar to many e.g. TR:E1359128 (EMBL:AL034443) long chain fatty acid CoA ligase from Streptomyces coelicolor (608 aa) fasta scores%3B opt: 1347%2C z-score: 1506.7%2C E(): 0%2C (51.3%25 identity in 608 aa overlap) and SW:LCFB_RAT long chain fatty acid CoA ligase from Rattus norvegicus (Rat) (699 aa) fasta scores%3B opt: 568%2C z-score: 634.7%2C E(): 4.7e-28%2C (30.2%25 identity in 589 aa overlap). Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and Prosite match to PS00455 AMP-binding domain signature. gene gene2132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2131 SCO2132 SCO2132 SC6G10.05c SC6G10.05c 2292487 2293725 - glycosyl transferase SC6G10.05c%2C possible glycosyl transferase%2C len: 412 aa%3B similar to TR:O53522 (EMBL:AL021957) hypothetical protein from Mycobacterium tuberculosis (399 aa) fasta scores%3B opt: 1276%2C z-score: 1452.2%2C E(): 0%2C (51.9%25 identity in 391 aa overlap) and SW:WCAL_SALTY colanic acid biosynthesis glycosyl transferase from the Rfb (O antigen) gene cluster of Salmonella typhimurium (406 aa) fasta scores%3B opt: 291%2C z-score: 334.2%2C E(): 2.6e-11%2C (29.0%25 identity in 300 aa overlap). Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene2133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2132 SCO2133 SCO2133 SC6G10.06 SC6G10.06 2293882 2295147 + hypothetical protein SC6G10.06%2C possible integral membrane protein%2C len: 421 aa%3B similar to hypothetical proteins eg. TR:P71708 (EMBL:Z80775) hypothetical protein from Mycobacterium tuberculosis fasta scores%3B opt: 230%2C z-score: 251.3%2C E(): 1.1e-06%2C (27.1%25 identity in 417 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene2134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2133 SCO2134 SCO2134 SC6G10.07c SC6G10.07c 2295175 2296332 - hypothetical protein SC6G10.07c%2C unknown%2C len: 385aa%3B similar to TR:O53523 (EMBL:AL021957) hypothetical protein from Mycobacterium tuberculosis (257 aa) fasta scores%3B opt: 225%2C z-score: 262.9%2C E(): 2.4e-07%2C (33.1%25 identity in 254 aa overlap). gene gene2135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2134 SCO2135 SCO2135 SC6G10.08c SC6G10.08c 2296454 2297470 - hypothetical protein SC6G10.08c%2C possible hypothetical protein%2C len: 338 aa%3B similar to TR:O69580 (EMBL:AL022602) hypothetical protein from Mycobacterium leprae (374 aa) fasta scores%3B opt: 382%2C z-score: 384.3%2C E(): 4.2e-14%2C (32.4%25 identity in 358 aa overlap). Also similar to several examples of Listeria P60 a major extracellular protein involved in the invasion of non-professional phagocytic cells eg. SW:P60_LISIV from Listeria ivanovii (524 aa) fasta scores%3B opt: 337%2C z-score: 338.3%2C E(): 1.5e-11%2C (29.1%25 identity in 309 aa overlap). Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family and the C-terminus%2C a probable membrane spanning hydrophobic region towards the N-terminus and two possible coiled coil regions. NOTE: highly similar to upstream gene%2C 6G10.09c%2C indicating a duplication event%3B fasta scores: opt: 1042%2C z-score: 843.1%2C E(): 0%2C (49.9%25 identity in 339 aa overlap). gene gene2136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2135 SCO2136 SCO2136 SC6G10.09c SC6G10.09c 2297707 2298750 - hypothetical protein SC6G10.09c%2C possible hypothetical protein%2C len: 347 aa%3B similar to TR:E1370194 (EMBL:Y13601) hypothetical protein from Streptomyces lividans (250 aa) fasta scores%3B opt: 371%2C z-score: 366.3%2C E(): 4.3e-13%2C (31.4%25 identity in 229 aa overlap). Also similar to several examples of Listeria P60 a major extracellular protein involved in the invasion of non-professional phagocytic cells e.g. SW:P60_LISMO from Listeria monocytogenes (484 aa) fasta scores%3B opt: 351%2C z-score: 343.1%2C E(): 8.3e-12%2C (33.3%25 identity in 201 aa overlap). Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family at the C-terminus%2C a probable N-terminal signal sequence and two possible coiled coils. NOTE: highly similar to downstream gene%2C 6G10.08c%2C indicating a duplication event%3B fasta scores: opt: 1042%2C z-score: 1027.7%2C E(): 0%2C (49.9%25 identity in 339 aa overlap) gene gene2137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2136 SCO2137 SCO2137 SC6G10.10c SC6G10.10c 2298982 2300325 - hypothetical protein SC6G10.10c%2C unknown%2C len: 447aa%3B some similarity to TR:Q60218 (EMBL:L10330) TraN from plasmid RP4 of Escherichia coli (261 aa) fasta scores%3B opt: 176%2C z-score: 185.4%2C E(): 0.005%2C (29.5%25 identity in 224 aa overlap). Contains probable coiled coil region. gene gene2138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2137 SCO2138 SCO2138 SC6G10.11c SC6G10.11c 2300388 2300627 - hypothetical protein SC6G10.11c%2C len: 79aa gene gene2139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2138 SCO2139 SCO2139 SC6G10.12 SC6G10.12 2300785 2301555 + hypothetical protein SC6G10.12%2C possible integral membrane protein%2C len: 256aa%3B similar to TR:O69868 (EMBL:AL023702) integral membrane protein from Streptomyces coelicolor (383 aa) fasta scores%3B opt: 569%2C z-score: 706.4%2C E(): 4.8e-32%2C (44.6%25 identity in 242 aa overlap). Contains possible hydrophobic membrane sapnning regions gene gene2140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2139 SCO2140 SCO2140 SC6G10.13 SC6G10.13 2301552 2301833 + transcriptional regulator SC6G10.13%2C possible transcriptional regulator%2C len: 93 aa%3B similar to many e.g. TR:O28868 (EMBL:AE001007) transcriptional regulatory protein%2C AsnC family from Archaeoglobus fulgidus (77 aa) fasta scores%3B opt: 148%2C z-score: 216.7%2C E(): 9.1e-05%2C (40.8%25 identity in 71 aa overlap) and SW: LRP_ECOLI Lrp%2C leucine responsive regulatory protein from Escherichia coli (163 aa) fasta scores%3B opt: 107%2C z-score: 157.6%2C E(): 0.18%2C (24.7%25 identity in 85 aa overlap). gene gene2141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2140 SCO2141 SCO2141 SC6G10.14 SC6G10.14 2301983 2302306 + small hydrophilic protein SC6G10.14%2C possible small hydrophilic protein%2C len: 107aa%3B contains possible N-terminal signal sequence. gene gene2142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2141 SCO2142 SCO2142 SC6G10.15 SC6G10.15 2302365 2303729 + two component sensor kinase SC6G10.15%2C possible two component sensor kinase%2C len: 454 aa%3B similar to many e.g. SW:CUTS_STRCO CutS%2C two component sensor kinase involved in the regulation of copper metabolism in Streptomyces lividans 66 (414 aa) fasta scores%3B opt: 537%2C z-score: 580.3%2C E(): 5.1e-25%2C (34.8%25 identity in 328 aa overlap). Contains Pfam match to entry PF00512 signal%2C Signal carboxyl-terminal domain and Pfam match to entry PF00672 DUF5%2C Domain found in bacterial signal proteins. Also contains a possible membrane spanning hydrophobic region gene gene2143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2142 SCO2143 SCO2143 SC6G10.16 SC6G10.16 2303726 2304391 + two component system response regulator SC6G10.16%2C possible two component system response regulator%2C len: 221aa%3B similar to many eg. SW:IRLR_BURPS two component response regulator involved in heavy-metal resistance in Burkholderia pseudomallei (229 aa) fasta scores%3B opt: 635%2C z-score: 758.0%2C E(): 0%2C (50.0%25 identity in 220 aa overlap). Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal. gene gene2144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2143 SCO2144 SCO2144 SC6G10.17 SC6G10.17 2304481 2305890 + integral membrane transporter SC6G10.17%2C possible integral membrane transporter%2C len: 469aa%3B similar to many eg. SW:CITT_ECOLI CitR%2C citrate transporter from Escherichia coli (487 aa) fasta scores%3B opt: 257%2C z-score: 284.2%2C E(): 1.6e-08%2C (23.3%25 identity in 454 aa overlap). Contains Pfam match to entry PF00939 Na_sulph_symp%2C Sodium:sulfate symporter transmembrane region%2C score -165.10%2C E-value 3.2e-06 and several probable membrane spanning hydrophobic regions. gene gene2145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2144 SCO2145 SCO2145 SC6G10.18 SC6G10.18 2305901 2307199 + glycerate kinase SC6G10.18%2C unknown%2C len: 432aa%3B similar to many hypothetical proteins eg. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores%3B opt: 1005%2C z-score: 1049.9%2C E(): 0%2C (44.1%25 identity in 381 aa overlap). Note predicted C-terminal overlap with downstream CDS. Simialr also to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK or S14A%2C 382 aa%3B fasta scores: opt: 1005 Z-score:1015.2 E(): 6.5e-49%3B 44.094%25 identity in 381 aa overlap gene gene2146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2145 SCO2146 SCO2146 SC6G10.19c SC6G10.19c 2307076 2308506 - aminotransferase SC6G10.19c%2C possible aminotransferase%2C len: 476 aa%3B similar to SW:CSDB_ECOLI (EMBL:AE000263) Escherichia coli selenocysteine lyase (EC 4.4.1.16) CsdB%2C 406 aa%3B fasta scores: opt: 565 Z-score: 628.7 E(): 2.3e-27%3B 33.862%25 identity in 378 aa overlap. Contains Pfam match to entry PF00266 aminotran_5%2C Aminotransferases class-V. Note: C-terminus overlaps with downstream gene. gene gene2147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2146 SCO2147 SCO2147 trpD trpD 2308851 2309915 - anthranilate phosphoribosyltransferase Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate gene gene2148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2147 SCO2148 SCO2148 qcrB qcrB 2310047 2311684 - cytochrome B subunit SC6G10.21c%2C qcrB%2C cytochrome B subunit%2C len: 545 aa%3B almost identical to one previously sequenced in Streptomyces lividans TR:G4154324 (EMBL:AF107888) (549 aa) fasta scores: opt: 3501%2C z-score: 3791.6%2C E(): 0%2C (95.5%25 identity in 550 aa overlap). Also similar to SW:QCRB_BACST cytochrome B subunit from Bacillus stearothermophilus (224 aa) fasta scores%3B opt: 409%2C z-score: 451.8%2C E(): 7.2e-18%2C (30.0%25 identity in 240 aa overlap). Contains Pfam match to entry PF00033 cytochrome_b_N%2C Cytochrome b(N-terminal)/b6/petB. Also contains several probable membrane spanning hydrophobic regions. gene gene2149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2148 SCO2149 SCO2149 qcrA qcrA 2311681 2312742 - Rieske iron-sulfur protein SC6G10.22c%2C qcrA%2C Rieske iron-sulfur protein%2C len: 353 aa%3B identical over the partial sequence of QcrA%2C Rieske iron-sulfur protein from Streptomyces lividans (170 aa) fasta scores%3B opt: 1174%2C z-score: 1332.%2C1 E(): 0%2C (100.0%25 identity in 169 aa overlap). SW:UCRI_BRAJA ubiquinol cytochrome C reductase iron-sulphur subunit (176 aa) fasta scores%3B opt: 156%2C z-score: 186.0%2C E(): 0.0047%2C (33.3%25 identity in 84 aa overlap). Contains Prosite match to PS00200 Rieske iron-sulfur protein signature 2 and possible hydrophobic membrane spanning regions gene gene2150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2149 SCO2150 SCO2150 qcrC qcrC 2312739 2313548 - cytochrome C heme-binding subunit SC6G10.23c%2C qcrC%2C cytochrome C heme-binding subunit%2C len: aa%3B similar to many eg. TR:O69583 (EMBL:AL022602) proposed QcrC protein from Mycobacterium leprae (164 aa) fasta scores%3B opt: 368%2C z-score: 374.3%2C E(): 1.5e-13%2C (45.4%25 identity in 141 aa overlap). Contains two Pfam matches to entry PF00034 cytochrome_c%2C Cytochrome c and two Prosite matches to PS00190 Cytochrome c family heme-binding site signature. Also contains possible membrane spanning hydrophobic regions. gene gene2151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2150 SCO2151 SCO2151 cox3 cox3 2313623 2314243 - cytochrome c oxidase subunit III SC6G10.24c%2C cox3%2C cytochrome c oxidase subunit III%2C len: 206aa%3B similar to many eg. SW:COX3_BACP3 caaC%2C cytochrome c oxidase subunit III from Bacillus PS3 (207 aa) fasta scores%3B opt: 397%2C z-score: 511.9%2C E(): 3.3e-21%2C (35.9%25 identity in 181 aa overlap). Contains Pfam match to entry PF00510 COX3%2C Cytochrome c oxidase subunit III. gene gene2152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2151 SCO2152 SCO2152 SC6G10.25 SC6G10.25 2314453 2314854 + response regulator SC6G10.25%2C possible response regulator%2C len: 133aa%3B similar to TR:P95183 (EMBL:Z83867) hypothetical protein from Mycobacterium tuberculosis (133 aa) fasta scores%3B opt: 474%2C z-score: 602.8%2C E(): 2.8e-26%2C (54.2%25 identity in 120 aa overlap) and TR:E1358527 (EMBL:AJ131213) response regulator from Streptomyces coelicolor (234 aa) fasta scores%3B opt: 122%2C z-score: 162.8%2C E(): 0.091%2C (28.5%25 identity in 130 aa overlap) gene gene2153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2152 SCO2153 SCO2153 SC6G10.26c SC6G10.26c 2314942 2316216 - hypothetical protein SC6G10.26c%2C possible hypothetical protein%2C len: 424aa%3B similar to many of undefined function eg. TR:O53223 (EMBL:AL021185) hypothetical protein from Mycobacterium tuberculosis (408 aa) fasta scores%3B opt: 867%2C z-score: 941.5%2C E(): 0%2C (35.2%25 identity in 403 aa overlap). Contains Prosite matches to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00213 Lipocalin signature. Also contains possible N-terminal signal sequence. gene gene2154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2153 SCO2154 SCO2154 SC6G10.27c SC6G10.27c 2316363 2316761 - hypothetical protein SC6G10.27c%2C possible integral membrane protein%2C len: 132aa%3B similar to proteins of undefined function eg. SW:Y00A_MYCTU hypothetical protein from Mycobacterium tuberculosis (139 aa) fasta scores%3B opt: 317%2C z-score: 403.3%2C E(): 3.7e-15%2C (38.3%25 identity in 133 aa overlap). gene gene2155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2154 SCO2155 SCO2155 cox1 cox1 2316758 2318494 - cytochrome c oxidase subunit I SC6G10.28c%2C cox1%2C cytochrome c oxidase subunit I%2C len: 578aa%3B similar to many eg. SW:COX1_BACFI cytochrome c oxidase polypeptide I from Bacillus firmus (624 aa) fasta scores%3B opt: 1835%2C z-score: 2056.2%2C E(): 0%2C (49.5%25 identity in 527 aa overlap). Contains Pfam match to entry PF00115 COX1%2C Cytochrome C and Quinol oxidase polypeptide I and Prosite matches to PS00152 ATP synthase alpha and beta subunits signature and PS00077 Heme-copper oxidase catalytic subunit%2C copper B binding region signature. Also contains several probable membrane spanning hydrophobic regions. gene gene2156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2155 SCO2156 SCO2156 cox cox 2318491 2319450 - cytochrome c oxidase subunit II SC6G10.29c%2C cox2%2C cytochrome c oxidase subunit II%2C len: 319aa%3B similar to many eg. SW:COX2_MYCTU cox2%2C cytochrome c oxidase subunit II from Mycobacterium tuberculosis (363 aa) fasta scores%3B opt: 417%2C z-score: 477.1%2C E(): 2.8e-19%2C (35.4%25 identity in 308 aa overlap). Contains two Pfam match to entry PF00116 COX2%2C Cytochrome C oxidase subunit II and Prosite match to PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. gene gene2157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2156 SCO2157 SCO2157 SC6G10.30 SC6G10.30 2319777 2321159 + aminotransferase SC6G10.30%2C probable aminotransferase%2C len: 460 aa%3B similar to many NifS-like proteins e.g. SW:NIFS_RHOSH NifS protein from Rhodobacter sphaeroides (387 aa) fasta scores%3B opt: 702%2C z-score: 760.5%2C E(): 0%2C (37.4%25 identity in 390 aa overlap). Contains Pfam matches to entry PF00266 aminotran_5%2C Aminotransferases class-V and entry PF01206 UPF0033%2C Uncharacterized protein family UPF0033. gene gene2158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2157 SCO2158 SCO2158 SC6G10.31c SC6G10.31c 2321282 2322298 - kinase SC6G10.31c%2C probable kinase%2C len: 338 aa%3B similar to many e.g. SW:RBSK_BACSU ribokinase from Bacillus subtilis (293 aa) fasta scores%3B opt: 222%2C z-score: 264.5%2C E(): 2e-07%2C (26.6%25 identity in 252 aa overlap). Contains Prosite matches to PS00583 pfkB family of carbohydrate kinases signature 1 and PS00485 Adenosine and AMP deaminase signature. gene gene2159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2158 SCO2159 SCO2159 SC6G10.32 SC6G10.32 2322389 2322598 + hypothetical protein SC6G10.32%2C unknown%2C len: 69aa gene gene2160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2159 SCO2160 SCO2160 SC6G10.33 SC6G10.33 2322715 2324265 + large membrane protein SC6G10.33%2C possible large membrane protein%2C len: 516 aa%3B contains possible hydrophobic membrane spanning region near the N-terminal domain gene gene2161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2160 SCO2161 SCO2161 SC6G10.34c SC6G10.34c 2324368 2324724 - hypothetical protein SC6G10.34c%2C conserved hypothetical protein%2C len: 118 aa%3B similar to many e.g. SW:YM04_MYCTU (EMBL:Z70283) protein RV2204c from Mycobacterium tuberculosis (118 aa) fasta scores%3B opt: 625%2C z-score: 766.6%2C E(): 0%2C (74.6%25 identity in 118 aa overlap). Contains PS01152 Hypothetical hesB/yadR/yfhF family signature gene gene2162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2161 SCO2162 SCO2162 SC6G10.35 SC6G10.35 2325064 2326248 + quinolinate synthetase 3 different subfamilies%3B catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate gene gene2163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2162 SCO2164 SCO2164 SC5F7.37c SC5F7.37c 2326327 2329452 - integral membrane efflux protein SC5F7.37c%2C possible integral membrane efflux protein%2C len: >822aa%3B similar to SW:ACRD_ECOLI acriflavin resistance efflux protein from Escherichia coli (1037 aa) fasta scores%3B opt: 628%2C z-score: 629.0%2C E(): 1.1e-27%2C (22.9%25 identity in 853 aa overlap). Also similar to TR:O31501 (EMBL:Z99107) hypothetical protein from Bacillus subtilis (1065 aa) fasta scores%3B opt: 968%2C z-score: 969.5%2C E(): 0%2C (29.4%25 identity in 874 aa overlap). Contains Pfam match to entry PF00873 ACR_tran%2C AcrB/AcrD/AcrF family. Also contains possible membrane spanning hydrophobic regions.~SC6G10A.02c%2C possible integral membrane efflux protein (fragment)%2C len: >253 aa%3B similar to C-terminal region of SW:CZCA_ALCSP (EMBL:D67044) Alcaligenes sp. cation efflux system protein CzcA%2C 1063 aa%3B fasta scores: opt: 474 z-score: 507.7 E(): 7.7e-21%3B 34.6%25 identity in 246 aa overlap. Contains Pfam match to entry PF00873 ACR_tran%2C AcrB/AcrD/AcrF family. Also contains possible hydrophobic membrane spanning regions gene gene2164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2164 SCO2165 SCO2165 SC5F7.36c SC5F7.36c 2329632 2330315 - two component system response regulator SC5F7.36c%2C probable two component system response regulator%2C len: 227 aa%3B similar to many others from Streptomyces coelicolor egs. TR:O69816 (EMBL:AL023496) proposed two component regulator (224 aa) fasta scores%3B opt: 753%2C z-score: 882.2%2C E(): 0%2C (57.4%25 identity in 223 aa overlap) and TR:Q53894 (EMBL:U51332) AbsA2 two component response regulator of antibiotic synthesis (222 aa) fasta scores%3B opt: 564%2C z-score: 663.8%2C E(): 1.2e-29%2C (44.6%25 identity in 222 aa overlap). Contains Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature and Pfam matches to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and to entry PF00072 response_reg%2C Response regulator receiver domain.Contains helix-turn-helix motif (+2.94 SD) 178-199aa. gene gene2165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2165 SCO2166 SCO2166 SC5F7.35c SC5F7.35c 2330312 2331562 - two component sensor kinase SC5F7.35c%2C probable two component sensor kinase%2C len: 416 aa%3B similar to many others from Streptomyces coelicolor egs. TR:CAB40930 (EMBL:AL049630) two component sensor kinase (401 aa) fasta scores%3B opt: 731%2C z-score: 799.1%2C E(): 0%2C (36.7%25 identity in 398 aa overlap) and TR:Q53893 (EMBL:U51332) two component sensor kinase for the regulation of antibiotic production (571 aa) fasta scores%3B opt: 429%2C z-score: 469.2%2C E(): 8.4e-19%2C (29.5%25 identity in 407 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene2166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2166 SCO2167 SCO2167 SC5F7.34c SC5F7.34c 2331727 2332011 - hypothetical protein SC5F7.34c%2C unknown%2C len: aa gene gene2167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2167 SCO2168 SCO2168 SC5F7.33c SC5F7.33c 2332033 2332812 - hypothetical protein SC5F7.33c%2C unknown%2C possible hydrophilic protein%2C len: 259aa%3B some similartity to others of undefined function eg. SW:Y617_SYNY3 hypothetical protein from Synechocystis sp. strain PCC6803 (267 aa) fasta scores%3B opt: 313%2C z-score: 322.8%2C E(): 1.2e-10%2C (30.6%25 identity in 232 aa overlap). Contains probable coiled coil regions approx. 35-55aa and 45-110aa. gene gene2168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2168 SCO2169 SCO2169 SC5F7.32 SC5F7.32 2332994 2333749 + hypothetical protein SC5F7.32%2C possible integral membrane protein%2C len: 251aa%3B contains possible membrane spanning hydrophobic regions. some similarity to TR:O32952 (EMBL:Z98741) hypothetical protein from Mycobacterium leprae (247 aa) fasta scores%3B opt: 335%2C z-score: 361.2%2C E(): 8.8e-13%2C (34.4%25 identity in 221 aa overlap). gene gene2169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2169 SCO2170 SCO2170 SC5F7.31 SC5F7.31 2333833 2334534 + methyltransferase SC5F7.31%2C possible methyltransferase%2C len: 233 aa%3B similar to SW:SMTA_ECOLI methyltransferase from Escherichia coli (261 aa) fasta scores%3B opt: 301%2C z-score: 359.0%2C E(): 1.2e-12%2C (31.1%25 identity in 212 aa overlap). gene gene2170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2170 SCO2171 SCO2171 SC5F7.30 SC5F7.30 2334636 2335724 + protease SC5F7.30%2C probable protease%2C len: 362aa%3B similar to many egs. SW:HTRA_ECOLI Protease Do from Escherichia coli (474 aa) fasta scores%3B opt: 505%2C z-score: 503.1%2C E(): 1.1e-20%2C (39.1%25 identity in 294 aa overlap). Contains possible membrane spanning hydrophobic regions. Also contains Pfam matches to entry PF00089 trypsin%2C Trypsin and to entry PF00595 PDZ%2C PDZ domain (Also known as DHR or GLGF). gene gene2171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2171 SCO2172 SCO2172 SC5F7.29c SC5F7.29c 2335755 2336003 - hypothetical protein SC5F7.29c%2C unknown%2C len: 82aa gene gene2172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2172 SCO2173 SCO2173 SC5F7.28 SC5F7.28 2336218 2337411 + adenosylcobinamide kinase/adenosylcobinamide phosphate guanyltransferase SC5F7.28%2C adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase%2C len: 397 aa%3B regions similar to different proteins. 1-220aa similar to TR:O05479 (EMBL:M86351) triacylglycerol acylhydrolase from Streptomyces sp. (481 aa) fasta scores%3B opt: 146%2C z-score: 158.6%2C E(): 0.17%2C (30.4%25 identity in 207 aa overlap). 220-397aa similar to many bifunctional adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferases in the biosynthesis of cobalamin (vitamin B12) eg. SW:COBU_SALTY adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium (181 aa) fasta scores%3B opt: 368%2C z-score: 398.3%2C E(): 7.5e-15%2C (41.7%25 identity in 175 aa overlap). gene gene2173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2173 SCO2174 SCO2174 SC5F7.27c SC5F7.27c 2337400 2338170 - transferase SC5F7.27c%2C possible transferase%2C len: 256 aa%3B region (120-210aa) similar to SW:UBIG_SALTY 3-demethylubiquinone-9 3-methyltransferase from Salmonella typhimurium (209 aa) fasta scores%3B opt: 142%2C z-score: 165.2%2C E(): 0.073%2C (31.6%25 identity in 98 aa overlap) gene gene2174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2174 SCO2175 SCO2175 cobT cobT 2338274 2339347 + nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5%2C6-dimethylbenzimidazole gene gene2175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2175 SCO2176 SCO2176 SC5F7.25c SC5F7.25c 2339770 2340510 - hypothetical protein SC5F7.25c%2C possible integral membrane protein%2C len: 246 aa%3B similar to TR:O53514 (EMBL:AL021957) integral membrane protein from Mycobacterium tuberculosis (295 aa) fasta scores%3B opt: 468%2C z-score: 539.2%2C E(): 1.1e-22%2C (42.3%25 identity in 260 aa overlap). Contains possible membrane spanning hydrophobic regions. Also contains Pfam match to entry PF00499 oxidored_q3%2C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 gene gene2176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2176 SCO2177 SCO2177 SC5F7.24 SC5F7.24 2340571 2341353 + adenosylcobinamide-GDP ribazoletransferase SC5F7.24%2C possible cobalamin (5'-phosphate) synthase%2C len: 260 aa%3B similar to many e.g. SW:COBS_SALTY cobalamin (5'-phosphate) synthase from Salmonella typhimurium (247 aa) fasta scores%3B opt: 309%2C z-score: 331.0%2C E(): 4.2e-11%2C (34.0%25 identity in 247 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene2177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2177 SCO2178 SCO2178 SC5F7.23c SC5F7.23c 2341371 2342219 - endo alpha-1%2C4 polygalactosaminidase SC5F7.23c%2C possible endo alpha-1%2C4 polygalactosaminidase%2C possibly %2C len: 282 aa%3B similar to TR:Q52423 (EMBL:D14846) endo alpha-1%2C4 polygalactosaminidase from Pseudomonas sp.881 (294 aa) fasta scores%3B opt: 759%2C z-score: 748.2%2C E(): 0%2C (44.2%25 identity in 278 aa overlap). Contains possible N-terminal signal sequence gene gene2178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2178 SCO2179 SCO2179 SC5F7.22 SC5F7.22 2342474 2344027 + leucyl aminopeptidase catalyzes the removal of N-terminal amino acids preferably leucine from various peptides gene gene2179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2179 SCO2180 SCO2180 pdhL pdhL 2344272 2345732 + dihydrolipoamide dehydrogenase E3 component of pyruvate complex%3B catalyzes the oxidation of dihydrolipoamide to lipoamide gene gene2180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2180 SCO2181 SCO2181 SC5F7.20 SC5F7.20 2345796 2347568 + 2-oxoglutarate dehydrogenase%2C E2 component%2C dihydrolipoamide succinyltransferase SC5F7.20%2C sucB%2C possible dihydrolipoamide succinyltransferase%2C len: 590 aa%3B similar to many egs. TR:AAC23517 (EMBL:AF068740) dihydrolipoamide succinyltransferase from Pseudomonas ovalis (407 aa) fasta scores%3B opt: 847%2C z-score: 602.5%2C E(): 3.2e-26%2C (41.9%25 identity in 453 aa overlap) and SW:ODO2_MYCTU dihydrolipoamide succinyltransferase from Mycobacterium tuberculosis (553 aa) fasta scores%3B opt: 1232%2C z-score: 866.2%2C E(): 0%2C (56.2%25 identity in 596 aa overlap). Contains two Pfam matches to entry PF00364 biotin_lipoyl%2C Biotin-requiring enzymes%2C Pfam match to entry PF00198 2-oxoacid_dh%2C 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and two Prosite matches to PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. gene gene2181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2181 SCO2182 SCO2182 SC5F7.19 SC5F7.19 2347778 2348401 + GntR family transcriptional regulator SC5F7.19%2C possible gntR-family transcriptional regulator%2C len: 207aa%3B similar to many egs. SW:GNTR_BACSU gluconate operon transcriptional repressor (243 aa) fasta scores%3B opt: 192%2C z-score: 240.4%2C E(): 4.7e-06%2C (31.1%25 identity in 180 aa overlap) and TR:CAA22369 (EMBL:AL034443) transcriptional regulator from Streptomyces coelicolor (225 aa) fasta scores%3B opt: 242%2C z-score: 300.9%2C E(): 2e-09%2C (32.2%25 identity in 199 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene2182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2182 SCO2183 SCO2183 aceE1 aceE1 2348740 2351439 + 2-oxoacid dehydrogenase subunit E1 paralogs to the E1 component of pyruvate dehydrogenase subunit E1 gene gene2183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2183 SCO2184 SCO2184 SC5F7.17 SC5F7.17 2351510 2352493 + transcriptional regulator SC5F7.17%2C possible transcriptional regulator%2C len: 327aa%3B similar to TR:O34920 (EMBL:AF027868) transcriptional regulator from Bacillus subtilis (313 aa) fasta scores%3B opt: 319%2C z-score: 380.6%2C E(): 7.3e-14%2C (27.3%25 identity in 330 aa overlap). Contains helix-turn-helix motif (+4.15 SD) 20-41aa. gene gene2184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2184 SCO2185 SCO2185 SC5F7.16 SC5F7.16 2352501 2352923 + hypothetical protein SC5F7.16%2C unknown%2C len: 140aa gene gene2185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2185 SCO2186 SCO2186 SC5F7.15 SC5F7.15 2352920 2353624 + hypothetical protein SC5F7.15%2C unknown%2C len: 234aa gene gene2186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2186 SCO2187 SCO2187 SC5F7.14c SC5F7.14c 2353659 2354585 - hypothetical protein SC5F7.14c%2C unknown%2C len: 308aa%3B similar to TR:O86334 (EMBL:Z97188) from Mycobacterium tuberculosis (539 aa) fasta scores%3B opt: 472%2C z-score: 514.3%2C E(): 2.6e-21%2C (37.5%25 identity in 208 aa overlap) gene gene2187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2187 SCO2188 SCO2188 SC5F7.13 SC5F7.13 2355010 2355858 + peptidase SC5F7.13%2C possible peptidase (hypothetical protein)%2C len: 282 aa%3B similar to TR:CAB38504 (EMBL:AL035636) serine protease from Streptomyces coelicolor (385 aa) fasta scores%3B opt: 873%2C z-score: 979.4%2C E(): 0%2C (49.5%25 identity in 281 aa overlap). Contains a weak Pfam match to entry PF00089 trypsin%2C Trypsin. Contains possible N-terminal region signal peptide sequence gene gene2188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2188 SCO2189 SCO2189 SC5F7.12c SC5F7.12c 2355882 2356391 - acetyltransferase SC5F7.12c%2C possible acetyltransferase%2C len: 169 aa%3B similar to SW:PTCR_ALCFA phosphinothricin acetyltransferase from Alcaligenes faecalis (197 aa) fasta scores%3B opt: 178%2C z-score: 226.5%2C E(): 2.8e-05%2C (36.0%25 identity in 136 aa overlap) and TR:O33583 (EMBL:S60706) nourseothricin acetyltransferase from Streptomyces noursei (190 aa) fasta scores%3B opt: 140%2C z-score: 180.8%2C E(): 0.0098%2C (29.3%25 identity in 150 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene2189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2189 SCO2190 SCO2190 SC5F7.11 SC5F7.11 2356470 2357579 + hypothetical protein SC5F7.11%2C unknown%2C len: 369aa%3B similar to SW:Y00R_MYCTU hypothetical protein from Mycobacterium tuberculosis (301 aa) fasta scores%3B opt: 885%2C z-score: 925.1%2C E(): 0%2C (46.9%25 identity in 290 aa overlap). gene gene2190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2190 SCO2191 SCO2191 SC5F7.10 SC5F7.10 2357793 2359196 + oxidoreductase SC5F7.10%2C probable oxidoreductase%2C len: 467 aa%3B low similarity to many e.g. SW:PUO_MICRU putrescine oxidase from Micrococcus rubens (478 aa) fasta scores%3B opt: 195%2C z-score: 192.3%2C E(): 0.0022%2C (42.7%25 identity in 110 aa overlap). gene gene2191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2191 SCO2192 SCO2192 SC5F7.09c SC5F7.09c 2359257 2360720 - regulator SC5F7.09c%2C possible regulator%2C len: 487 aa%3B similar to others from Streptomyces spp. e.g. TR:Q53958 (EMBL:M80614) sporulation associated proteins from Streptomyces coelicolor (473 aa) fasta scores%3B opt: 728%2C z-score: 812.2%2C E(): 0%2C (39.7%25 identity in 489 aa overlap) and TR:O88053 (EMBL:AL031541) transcriptional regulator from Streptomyces coelicolor (446 aa) fasta scores%3B opt: 501%2C z-score: 560.4%2C E(): 7e-24%2C (33.8%25 identity in 459 aa overlap). gene gene2192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2192 SCO2193 SCO2193 lipB lipB 2360955 2361752 + lipoyltransferase lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse%3B lipoate-protein ligase B%3B transfers lipoate to apolipoproteins%3B involved in lipoate metabolism gene gene2193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2193 SCO2194 SCO2194 lipA lipA 2361907 2362860 + lipoyl synthase catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group gene gene2194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2194 SCO2195 SCO2195 SC5F7.06 SC5F7.06 2363105 2363320 + hypothetical protein SC5F7.06%2C unknown%2C len: 71aa gene gene2195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2195 SCO2196 SCO2196 SC5F7.05 SC5F7.05 2363402 2364106 + hypothetical protein SC5F7.05%2C possible integral membrane protein%2C len: 234aa%3B similar to SW:Y00U_MYCTU hypothetical protein from Mycobacterium tuberculosis (250 aa) fasta scores%3B opt: 574%2C z-score: 642.0%2C E(): 2e-28%2C (39.4%25 identity in 226 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene2196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2196 SCO2197 SCO2197 SC3H12.05c SC3H12.05c 2364217 2364684 - hypothetical protein SC3H12.05c%2C possible integral membrane protein%2C len: 155 aa%3B identical to previously sequenced TR:CAB51281 (EMBL:AL096872) Streptomyces coelicolor hypothetical 16.6 kD protein SC5F7.04c%2C 155 aa and similar to SW:YCKC_BACSU (EMBL:D50453) Bacillus subtilis hypothetical 17.0 kD protein in ComJ 5'region (ORF3) YckC%2C 151 aa%3B fasta scores: opt: 108 z-score: 138.4 E(): 2.5%3B 33.1%25 identity in 118 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2197 SCO2198 SCO2198 glnA glnA 2364905 2366314 + glutamine synthetase SC3H12.06%2C glnA%2C glutamine synthetase I%2C len: 469 aa%3B identical to previously sequenced SW:GLNA_STRCO (EMBL:M23172) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnA%2C 469 aa and to previously sequenced TR:CAB51282 (EMBL:AL096872) Streptomyces coelicolor glutamine synthetase I SC5F7.03%2C 469 aa and highly similar to SW:GLN1_STRVR (EMBL:X70924) Streptomyces viridochromogenes glutamine synthetase I (EC 6.3.1.2) (glutamate-ammonia ligase I) GlnI or GlnA%2C 469 aa%3B fasta scores: opt: 2905 z-score: 3417.5 E(): 0%3B 90.6%25 identity in 469 aa overlap. Contains Pfam match to entry PF00120 gln-synt%2C Glutamine synthetase and three Prosite matches to entries PS00180 Glutamine synthetase signature 1%2C PS00181 Glutamine synthetase ATP-binding region signature and PS00182 Glutamine synthetase class-I adenylation site gene gene2198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2198 SCO2199 SCO2199 SC3H12.07 SC3H12.07 2366476 2366745 + hypothetical protein SC3H12.07%2C possible integral membrane protein%2C len: 89 aa%3B identical to previously sequenced TR:CAB51283 (EMBL:AL096872) Streptomyces coelicolor hypothetical protein SC5F7.02%2C 89 aa. Contains possible hydrophobic membrane spanning regions gene gene2199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2199 SCO2200 SCO2200 SC3H12.08c SC3H12.08c 2366795 2367634 - hypothetical protein SC3H12.08c%2C hypothetical protein%2C len: 279 aa%3B identical to N-terminal region of previously sequenced TR:CAB58282 (EMBL:AL121850) Streptomyces coelicolor conserved hypothetical protein SCC78.01c (fragment)%2C 234 aa%2C identical to C-terminal region of TR:CAB51284 (EMBLAL096872:) Streptomyces coelicolor hypothetical 9.2 kD protein SC5F7.01c (fragment)%2C 85 aa and similar to TR:O30485 (EMBL:AF007101) Streptomyces hygroscopicus hypothetical 29.8 kD protein%2C 282 aa%3B fasta scores: opt: 559 z-score: 634.1 E(): 6.1e-28%3B 40.6%25 identity in 286 aa overlap gene gene2200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2200 SCO2201 SCO2201 SC3H12.09 SC3H12.09 2367728 2368099 + hypothetical protein SC3H12.09%2C conserved hypothetical protein%2C len: 123 aa%3B identical to previously sequenced TR:CAB58283 (EMBL:AL121850) Streptomyces coelicolor conserved hypothetical protein SCC78.02%2C 123 aa and similar to TR:Q9ZBQ5 (EMBL:AL034447) Streptomyces coelicolor hypothetical 17.8 kD protein SC7A1.18c%2C 141 aa%3B fasta scores: opt: 317 z-score: 412.3 E(): 1.4e-15%3B 44.6%25 identity in 112 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function gene gene2201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2201 SCO2202 SCO2202 htpX2 htpX2 2368178 2369092 + heat shock protein HtpX metalloprotease gene gene2202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2202 SCO2203 SCO2203 SC3H12.11 SC3H12.11 2369102 2369680 + hypothetical protein SC3H12.11%2C hypothetical protein%2C len: 192 aa%3B identical to previously sequenced TR:CAB58285 (EMBL:AL121850) Streptomyces coelicolor hypothetical 20.8 kD protein SCC78.04 and similar to SW:YMU5_STRCM (EMBL:L10064) Streptomyces cinnamonensis hypothetical 25.0 kD protein in MutA 5'region (ORF-D)%2C 237 aa%3B fasta scores: opt: 114 z-score: 145.0 E(): 1.1%3B 31.1%25 identity in 151 aa overlap gene gene2203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2203 SCO2204 SCO2204 SC3H12.12 SC3H12.12 2369767 2370954 + hypothetical protein SC3H12.12%2C hypothetical protein%2C len: 395 aa%3B identical to N-terminal region of previously sequenced TR:CAB58286 (EMBL:AL121850) Streptomyces coelicolor hypothetical 37.4 kD protein (fragment) SCC78.05%2C 347 aa gene gene2204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2204 SCO2205 SCO2205 SC3H12.13c SC3H12.13c 2371009 2371323 - hypothetical protein SC3H12.13c%2C unknown%2C len: 104 aa gene gene2205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2205 SCO2206 SCO2206 arsC arsC 2371456 2371857 + hypothetical protein SC3H12.14%2C arsC%2C arsenate reductase (partial CDS)%2C len: >47 aa%3B identical to N-terminal region of previously sequenced TR:Q9X954 (EMBL:Y13833) Streptomyces coelicolor arsenate reductase (fragment) ArsC%2C 117 aa and to SW:YGL1_STRVR (EMBL:X52842) Streptomyces viridochromogenes hypothetical 13.4 kD protein in GlnII region (ORF1)%2C 119 aa~SC10B7.01%2C arsC%2C arsenate reductase (fragment)%2C len: >117 aa%3B identical to previously sequenced TR:Q9X954 (EMBL:Y13833) Streptomyces coelicolor aresenate reductase (fragment)%2C 117 aa%2C highly similar to SW:YGL1_STRVR (EMBL:X52842) Streptomyces viridochromogenes hypothetical 13.4 kD protein in GlnII region (ORF1)%2C 119 aa%3B fasta scores: opt: 695 z-score: 873.2 E(): 0%3B 86.3%25 identity in 117 aa overlap and similar to SW:ARSC_ECOLI (EMBL:U00039%3B) Escherichia coli arsenate reductase (arsenical pump modifier) ArsC%2C 141 aa%3B fasta scores: opt: 202 z-score: 264.7 E(): 2.3e-07%3B 32.2%25 identity in 115 aa overlap gene gene2206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2206 SCO2207 SCO2207 SC10B7.02 SC10B7.02 2371976 2372671 + hypothetical protein SC10B7.02%2C hypothetical hypothetical protein%2C len: 231 aa%3B identical to previously sequenced TR:Q9X955 (EMBL:Y13833) Streptomyces coelicolor hypothetical 23.4 kD protein precursor. Contains a possible N-terminal region signal peptide sequence gene gene2207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2207 SCO2208 SCO2208 SC10B7.03c SC10B7.03c 2372674 2373546 - carboxylesterase SC10B7.03c%2C probable carboxylesterase%2C len: 290 aa%3B identical to previously sequenced TR:Q9X956 (EMBL:Y13833) Streptomyces coelicolor hypothetical 30.8 kD protein%2C 290 aa and similar to TR:Q59248 (EMBL:X82892) Bacillus subtilis carboxylesterase NP (EC 3.1.1.1) Nap%2C 300 aa%3B fasta scores: opt: 438 z-score: 516.3 E(): 2.2e-21%3B 31.5%25 identity in 292 aa overlap gene gene2208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2208 SCO2209 SCO2209 SC10B7.04 SC10B7.04 2373658 2374182 + transcriptional regulator S10B7.04 probable transcriptional regulator%2C len: 174 aa%3B identical to previously sequenced TR:Q9X957 (EMBL:Y13833) Streptomyces coelicolor hypothetical 19.0 kD protein%2C 174 aa and similar to TR:Q9XA85 (EMBL:AL096837) Streptomyces coelicolor marR-family transcriptional regulator%2C SCF43A.30c%2C 168 aa%3B fasta scores: opt: 276 z-score: 336.5 E(): 2.3e-11%3B 39.9%25 identity in 153 aa overlap gene gene2209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2209 SCO2210 SCO2210 glnII glnII 2374319 2375350 + glutamine synthetase SC10B7.05%2C glnII%2C glutamine synthetase%2C len: 343 aa%3B identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII%2C 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII%2C 343 aa%3B fasta scores: opt: 2196 z-score: 2572.0 E(): 0%3B 91.0%25 identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt%2C Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signature 1 and PS00181 Glutamine synthetase ATP-binding region signature gene gene2210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2210 SCO2211 SCO2211 SC10B7.06 SC10B7.06 2375406 2376335 + hypothetical protein SC10B7.06%2C unknown%2C len: 309 aa gene gene2211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2211 SCO2212 SCO2212 SC10B7.07 SC10B7.07 2376423 2376545 + hypothetical protein SC10B7.07%2C unknown%2C len: 40 aa gene gene2212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2212 SCO2213 SCO2213 SC10B7.08 SC10B7.08 2376676 2377257 + regulatory protein SC10B7.08%2C probable regulatory protein%2C len: 193 aa%3B C-terminal region similar to C-terminal region of SW:GLNR_STRCO (EMBL:L03213) Streptomyces coelicolor transcriptional regulatory protein GlnR%2C 267 aa%3B fasta scores: opt: 330 z-score: 356.0 E(): 1.9e-12%3B 47.1%25 identity in 121 aa overlap. Contains Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene2213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2213 SCO2214 SCO2214 SC10B7.09 SC10B7.09 2377262 2378362 + reductase SC10B7.09%2C possible reductase%2C len: 366 aa%3B similar to TR:Q9ZA37 (EMBL:AJ011500) Streptomyces violaceoruber DTDP4-keto-6-deoxyhexose reductase%2C 304 aa%3B fasta scores: opt: 212 z-score: 236.4 E(): 8.7e-06%3B 31.6%25 identity in 285 aa overlap gene gene2214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2214 SCO2215 SCO2215 SC10B7.10 SC10B7.10 2378415 2379692 + two-component system sensor kinase SC10B7.10%2C possible two-component system sensor kinase%2C len: 425 aa%3B similar to various sensor kinases%2C e.g. TR:Q9ZBS5 (EMBL:AL034446) Streptomyces coelicolor SC1A9.27c%2C 303 aa%3B fasta scores: opt: 304 z-score: 337.8 E(): 2e-11%3B 29.1%25 identity in 306 aa overlap and low similarity to C-terminal region of SW:NARX_ECOLI (EMBL:X13360) Escherichia coli mitrate/nitrite sensor protein (EC 2.7.3.-) NarX%2C 598 aa%3B fasta scores: opt: 214 z-score: 235.8 E(): 9.4e-06%3B 27.8%25 identity in 194 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2215 SCO2216 SCO2216 SC10B7.11 SC10B7.11 2379677 2380330 + two-component system response regulator SC10B7.11%2C probable two-component system response regulator%2C len: 217 aa%3B similar to TR:Q9X8Q7 (EMBL:AL049754) Streptomyces coelicolor two-component system regulator SCH10.18c%2C 228 aa%3B fasta scores: opt: 349 z-score: 426.3 E(): 2.3e-16%3B 34.8%25 identity in 221 aa overlap and to Streptomyces coelicolor SCC75.27c%2C 228 aa%3B fasta scores: opt: 722 z-score: 711.8 E(): 2.9e-34%3B 54.4%25 identity in 217 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family gene gene2216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2216 SCO2217 SCO2217 SC10B7.12 SC10B7.12 2380490 2381995 + hypothetical protein SC10B7.12%2C probable hypothetical protein%2C len: 501 aa%3B similar to TR:CAB61161 (EMBL:AL132973) Streptomyces coelicolor membrane protein%2C SCF91.04c%2C 718 aa%3B fasta scores: opt: 1496 z-score: 1486.8 E(): 0%3B 55.1%25 identity in 523 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2217 SCO2218 SCO2218 SC10B7.13c SC10B7.13c 2382072 2382518 - lipoprotein SC10B7.13c%2C possible lipoprotein%2C len: 148 aa%3B similar to TR:O07722 (EMBL:Z97193) Mycobacterium tuberculosis hypothetical 19.8 kD protein MTCY180.07%2C 201 aa%3B fasta scores: opt: 121 z-score: 149.5 E(): 0.6%3B 33.1%25 identity in 160 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene2218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2218 SCO2219 SCO2219 SC10B7.14 SC10B7.14 2382545 2383162 + hypothetical protein SC10B7.14%2C hypothetical protein%2C len: 205 aa%3B C-terminal region similar to TR:Q9RUW3 (EMBL:AE001974) Deinococcus radiodurans hypothetical protein DR1267%2C 163 aa%3B fasta scores: opt: 471 Z-score: 554.2 E(): 3.1e-23%3B 52.761%25 identity in 163 aa overlap gene gene2219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2219 SCO2220 SCO2220 SC10B7.15 SC10B7.15 2383230 2385161 + hypothetical protein SC10B7.15%2C unknown%2C len: 643 aa gene gene2220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2220 SCO2221 SCO2221 SC10B7.16 SC10B7.16 2385265 2386155 + hypothetical protein SC10B7.16%2C hypothetical protein%2C len: 296 aa%3B similar to TR:O33319 (EMBL:AL008967) Mycobacterium tuberculosis hypothetical 40.2 kD protein MTV002.42c%2C 356 aa%3B fasta scores: opt: 980 z-score: 1190.8 E(): 0%3B 51.2%25 identity in 281 aa overlap gene gene2221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2221 SCO2222 SCO2222 SC10B7.17 SC10B7.17 2386152 2387246 + iron-sulfur oxidoreductase SC10B7.17%2C probable iron-sulfur oxidoreductase ( hypothetical protein)%2C len: 364 aa%3B similar to TR:O88034 (EMBL:AL031107) Streptomyces coelicolor iron-sulfur oxidoreductase beta subunit SC5A7.28c%2C 313 aa%3B fasta scores: opt: 1032 z-score: 1177.8 E(): 0%3B 55.2%25 identity in 310 aa overlap and to SW:POBB_PSEPS (EMBL:X78823) Pseudomonas pseudoalcaligenes phenoxybenzoate dioxygenase beta subunit (EC 1.-.-.-.) PobB%2C 319 aa%3B fasta scores: opt: 680 z-score: 777.9 E(): 0%3B 40.8%25 identity in 314 aa overlap. Contains two matches to Pfam entries Pfam match to entry PF00175 oxidored_fad%2C Oxidoreductase FAD/NAD-binding and Pfam match to entry PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains domain match to Prosite entry PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature. Contains possible N-terminal region signal peptide sequence gene gene2222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2222 SCO2223 SCO2223 SC10B7.18 SC10B7.18 2387313 2388005 + TetR family transcriptional regulator SC10B7%2C18%2C possible tetR-family transcriptional regulator%2C len: 230 aa%3B similar to TR:Q9XAE5 (EMBL:AL079356) Streptomyces coelicolor hypothetical 24.2 kD protein SC6G9.37%2C 217 aa%3B fasta scores: opt: 688 z-score: 811.4 E(): 0%3B 52.4%25 identity in 210 aa overlap and to TR:Q9WZT0 (EMBL:AE001749) Thermotoga maritima transcriptional regulator%2C tetR family%2C TM0823%2C 190 aa%3B fasta scores: opt: 169 z-score: 208.1 E(): 0.00033%3B 32.6%25 identity in 89 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 34..55 (+4.48 SD) gene gene2223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2223 SCO2224 SCO2224 SC10B7.19 SC10B7.19 2388002 2388466 + hypothetical protein SC10B7.19%2C unknown%2C len: 154 aa. High content in alanine and proline amino acid residues. Also high G+C content (80.3%25) gene gene2224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2224 SCO2225 SCO2225 SC10B7.20c SC10B7.20c 2388485 2388844 - isomerase SC10B7.20c%2C possible isomerase%2C len: 119 aa%3B low similarities to SW:HPCD_ECOLI (EMBL:X53666) Escherichia coli 5-carboxymethyl-2-hydroxymuconate delta-isomerase HpcD%2C 125 aa%3B fasta scores: opt: 104 z-score: 146.1 E(): 0.93%3B 21.4%25 identity in 112 aa overlap gene gene2225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2225 SCO2226 SCO2226 SC10B7.21c SC10B7.21c 2388900 2394296 - bifunctional alpha-amylase/dextrinase SC10B7.21c%2C probable bi-functional protein ( alpha-amylase/dextrinase)%2C len: 1798 aa%3B N-terminal identical to SW:AMY_STRLI (EMBL:X70255) Streptomyces lividans alpha-amylase precursor (EC 3.2.1.1) Amy%2C 919 aa and C-terminal similar to TR:O48541 (EMBL:AF022725) Hordeum vulgare (Barley) limit dextrinase HVLD99%2C 904 aa%3B fasta scores: opt: 2114 z-score: 2193.6 E(): 0%3B 42.4%25 identity in 887 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase. Contains also possible N-terminal region signal peptide sequence gene gene2226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2226 SCO2227 SCO2227 SC10B7.22c SC10B7.22c 2394422 2394982 - acetyltransferase SC10B7.22c possible acetyltransferase%2C len: 186 aa%3B similar to TR:Q9XAQ0 (EMBL:AL078618) Streptomyces coelicolor acetyltransferase SC10A7.25%2C 187 aa%3B fasta scores: opt: 160 z-score: 203.0 E(): 0.00063%3B 29.9%25 identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene2227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2227 SCO2228 SCO2228 aglA aglA 2395074 2396807 - alpha-glucosidase SC10B7.23c%2C aglA%2C alpha-glucosidase%2C len: 577 aa%3B highly similar to TR:P72463 (EMBL:Y08304) Streptomyces limosus alpha-glucosidase AglA%2C 391 aa%3B fasta scores: opt: 1453 z-score: 1607.1 E(): 0%3B 72.0%25 identity in 347 aa overlap%2C to TR:AAD50603 (EMBL:AF096282) Thermus aquaticus alpha-glucosidase%2C 529 aa%3B fasta scores: opt: 925 z-score: 1022.3 E(): 0%3B 40.2%25 identity in 567 aa overlap and to SW:MAL2_DROVI (EMBL:AF006573) Drosophila virilis maltase 2 precursor (EC 3.2.1.20) Mal2%2C 524 aa%3B fasta scores: opt: 870 z-score: 961.6 E(): 0%3B 36.2%25 identity in 516 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene2228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2228 SCO2229 SCO2229 malG malG 2396944 2397855 - maltose permease SC10B7.24c%2C malG%2C maltose permease%2C len: 303 aa%3B identical to previously sequenced TR:P72399 (EMBL:Y07706) Streptomyces coelicolor maltose permease MalG%2C 302 aa and similar to SW:MALG_ECOLI (EMBL:X02871) Escherichia coli maltose transport system permease MalG%2C 296 aa%3B fasta scores: opt: 476 z-score: 570.0 E(): 2.3e-24%3B 34.1%25 identity in 293 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene2229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2229 SCO2230 SCO2230 malF malF 2397869 2398873 - maltose permease SC10B7.25c%2C malF%2C maltose permease%2C len: 334 aa%3B identical to previously sequenced TR:P72398 (EMBL:Y07706) Streptomyces coelicolor maltose permease MalF%2C 334 aa and similar to SW:MALF_ECOLI (EMBL:J01648) Escherichia coli maltose transport system permease MalF%2C 514 aa%3B fasta scores: opt: 424 z-score: 504.4 E(): 1e-20%3B 33.9%25 identity in 239 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophonic membrane spanning regions gene gene2230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2230 SCO2231 SCO2231 malE malE 2398988 2400259 - maltose-binding protein SC10B7.26c%2C malE%2C maltose-binding protein%2C len: 423 aa%3B identical to previously sequenced TR:P72397 (EMBL:Y07706) Streptomyces coelicolor maltose-binding protein MalE%2C 423 aa and similar to SW:MALX_STRPN (EMBL:L08611) Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX%2C 423 aa%3B fasta scores: opt: 431 z-score: 470.1 E(): 8.4e-19%3B 28.1%25 identity in 434 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and two matches to Prosite entries PS00013 Prokaryotic membrane lipoprotein lipid attachment site (correctly situated) and PS01037 Bacterial extracellular solute-binding proteins%2C family 1 signature. Contains also possible N-terminal region peptide signal sequence gene gene2231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2231 SCO2232 SCO2232 malR malR 2400651 2401685 + maltose operon transcriptional repressor SC10B7.27%2C malR%2C maltose operon transcriptional repressor%2C len: 344 aa%3B identical to previously sequenced SW:MALR_STRCO (EMBL:Y07706) Streptomyces coelicolor maltose operon transcriptional repressor MalR%2C 344 aa and highly similar to SW:REGL_STRLI (EMBL:X98242) Streptomyces lividans transcriptional regulatory protein RegL%2C 345 aa%3B fasta scores: opt: 2098 z-score: 2315.7 E(): 0%3B 95.4%25 identity in 345 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Contains a possible helix-turn-helix motif at residues 3..24 (+6.54 SD) gene gene2232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2232 SCO2233 SCO2233 SC10B7.28 SC10B7.28 2401780 2402643 + hypothetical protein SC10B7.28%2C probable integral membrane protein%2C len: 287 aa%3B similar to TR:Q9XAN7 (EMBL:AL079355) Streptomyces coelicolor membrane protein SC4C6.03c%2C 271 aa%3B fasta scores: opt: 489 z-score: 586.3 E(): 2.8e-25%3B 38.0%25 identity in 255 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2233 SCO2234 SCO2234 glnE glnE 2402769 2405768 - bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase%3B also catalyzes the reverse reaction - deadenylation%3B adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme gene gene2234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2234 SCO2235 SCO2235 SCBAC17D6.02 SCBAC17D6.02 2405942 2406205 + hypothetical protein SCBAC17D6.02%2C conserved hypothetical protein%2C len: 87 aa%3B identical to previously sequenced SW:YU1E_STRCO (EMBL:Y17736) Streptomyces coelicolor hypothetical 9.7 kDa protein (ORFU1E)%2C 87 aa and similar to SW:YEFM_ECOLI (EMBL:AE000293) Escherichia coli hypothetical 9.3 kDa protein in sbcB-hisL intergenic region%2C 83 aa%3B fasta scores: opt: 250 Z-score: 348.4 bits: 68.9 E(): 8e-12%3B 51.852%25 identity in 81 aa overlap. Contains Pfam match to entry PF02604 DUF172%2C Uncharacterized ACR%2C COG2161 gene gene2235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2235 SCO2236 SCO2236 SCBAC17D6.03 SCBAC17D6.03 2406202 2406456 + hypothetical protein SCBAC17D6.03%2C conserved hypothetical protein%2C len: 84 aa%3B identical to previously sequenced TR:Q9Z4V8 (EMBL:Y17736) Streptomyces coelicolor hypothetical 10.0 kDa protein%2C 84 aa and similar to SW:YOEB_ECOLI (EMBL:AE000293) Escherichia coli hypothetical 10.2 kDa protein in sbcB-hisL intergenic region%2C 84 aa%3B fasta scores: opt: 354 Z-score: 476.5 bits: 92.5 E(): 5.9e-19%3B 53.571%25 identity in 84 aa overlap gene gene2236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2236 SCO2237 SCO2237 SCBAC17D6.04 SCBAC17D6.04 2406519 2406965 + lyase SCBAC17D6.04%2C possible lyase%2C len: 148 aa%3B similar to TR:Q9FBS1 (EMBL:AL391072) Streptomyces coelicolor lyase SC9A4.33c%2C 143 aa%3B fasta scores: opt: 287 Z-score: 354.0 bits: 71.5 E(): 3.9e-12%3B 41.497%25 identity in 147 aa overlap. Contains 2x Pfam matches to entry PF00903 Glyoxalase%2C Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily gene gene2237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2237 SCO2238 SCO2238 nadE nadE 2406988 2408829 - NAD(+) synthase (glutamine-hydrolysing) SCBAC17D6.05c%2C nadE%2C NAD(+) synthase (glutamine-hydrolysing)%2C len: 613 aa%3B identical to TR:Q9Z4V9 (EMBL:Y17736) Streptomyces coelicolor NAD(+) synthase (glutamine-hydrolysing) (EC 6.3.5.1) (fragment) NadE%2C 538 aa and highly similar to SW:NADE_RHOCA (EMBL:X59399) Rhodobacter capsulatus glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolysing]) NadE or AdgA%2C 552 aa%3B fasta scores: opt: 631 Z-score: 697.6 bits: 139.0 E(): 2.8e-31%3B 43.645%25 identity in 598 aa overlap. Contains Pfam matches to entries PF00795 CN_hydrolase%2C Carbon-nitrogen hydrolase and PF02540 NAD_synthase%2C NAD synthase and matches to Prosite entries PS00920 Nitrilases / cyanide hydratase signature 1 and PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site gene gene2238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2238 SCO2239 SCO2239 SC1G2.01c SC1G2.01c 2408840 2409466 - hypothetical protein SC1G2.01c%2C possible hypothetical protein%2C partial CDS%2C len: >92 aa. Weakly similar to a protein of unknown function from Synechocystis sp. (strain PCC 6803) TR:Q55943(EMBL:D64005) (196 aa)%2C fasta scores opt: 109 z-score: 144.6 E():1.1 28.9%25 identity in 83 aa overlap. Contains a a possible N-terminal signal sequence.~SCBAC17D6.06c%2C conserved hypothetical protein (fragment)%2C len: >149 aa%3B similar to TR:Q9RVD0 (EMBL:AE001960) Deinococcus radiodurans conserved hypothetical protein DR1099%2C 197 aa%3B fasta scores:opt: 179 Z-score: 226.9 bits: 48.4 E(): 4.7e-05%3B 35.821%25 identity in 134 aa overlap gene gene2239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2239 SCO2240 SCO2240 SC1G2.02c SC1G2.02c 2409463 2410131 - hypothetical protein SC1G2.02c%2C possible membrane protein%2C len: 222 aa. Contains a possible N-terminal membrane spanning hydrophobic domain. gene gene2240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2240 SCO2241 SCO2241 SC1G2.03 SC1G2.03 2410423 2411784 + glutamine synthetase SC1G2.03%2C probable glutamine synthetase (EC 6.3.1.2)%2C len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa)%2C fasta scores opt: 1017 z-score: 1188.9 E():0 44.4%25 identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa)%2C fasta scores opt: 2114 z-score: 2469.2 E():0 70.2%25 identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt%2C Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase ATP-binding region signature. gene gene2241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2241 SCO2242 SCO2242 SC1G2.04c SC1G2.04c 2411818 2412264 - hypothetical protein SC1G2.04c%2C possible membrane protein%2C len: 148 aa. Highly similar to a protein of undefined function from Streptomyces coelicolor TR:Q9Z550(EMBL:AL035212) SC9B2.09 (148 aa)%2C fasta scores opt: 727 z-score: 888.0 E():0 75.5%25 identity in 147 aa overlap. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene2242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2242 SCO2243 SCO2243 SC1G2.05 SC1G2.05 2412355 2412933 + TetR family transcriptional regulator SC1G2.05%2C possible TetR-family transcriptional regulator%2C len: 192 aa. Similar to Bacillus subtilis TR:O34892 (EMBL:AF027868) transcription regulator YobS (191 aa)%2C fasta scores opt: 179 z-score: 219.4 E(): 7.7e-05 27.9%25 identity in 165 aa overlap. Also highly similar to another transcriptional regulator from Streptomyces coelicolor TR:Q9Z551 (EMBL:AL035212) SC9B2.08C (192 aa)%2C fasta scores opt: 1071 z-score: 1249.2 E(): 0 87.0%25 identity in 192 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with a possible helix-turn-helix motif situated between residues 34..55 (+4.02 SD). gene gene2243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2243 SCO2244 SCO2244 SC1G2.06c SC1G2.06c 2412958 2415018 - Ser/Thr protein kinase SC1G2.06c%2C probable Ser/Thr protein kinase%2C len: 686 aa. Highly similar to many Ser/Thr protein kinases including: Streptomyces coelicolor SW:AFSK_STRCO (EMBL:D15062) AfsK (799 aa)%2C fasta scores opt: 818 z-score: 736.0 E():0 34.2%25 identity in 658 aa overlap and Thermomonospora curvata SW:PKWA_THECU (EMBL:U23820) PkwA (742 aa)%2C fasta scores opt: 1065 z-score: 956.9 E():0 37.0%25 identity in 763 aa overlap. Contains a Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and 3xPfam matches to entry PF00400 WD40%2C WD domain%2C G-beta repeat. Also contains Prosite hits to PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00678 Trp-Asp (WD) repeats signature%2C PS00108 Ser/Thr protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature. gene gene2244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2244 SCO2245 SCO2245 SC1G2.07c SC1G2.07c 2415027 2415236 - hypothetical protein SC1G2.07c%2C unknown%2C len: 69 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86600(EMBL:AL031514) SC2H4.17C (81 aa)%2C fasta scores opt: 200 z-score: 296.9 E(): 3.7e-09 49.2%25 identity in 65 aa overlap%2C TR:O86677(EMBL:AL031371) SC4G2.04 (67 aa)%2C fasta scores opt: 170 z-score: 256.6 E(): 6.5e-07 55.6%25 identity in 54 aa overlap and TR:Q9Z544(EMBL:AL035212) SC9B2.15C (77 aa)%2C fasta scores opt: 165 z-score: 248.7 E(): 1.8e-06 55.1%25 identity in 49 aa overlap. Also similar to OrfD located within a novel antibiotic regulatory locus%2C abaA%2C in Streptomyces coelicolor TR:Q53896(EMBL:X60316) (75 aa)%2C fasta scores opt: 125 z-score: 193.4 E(): 0.0022 37.0%25 identity in 54 aa overlap. This gene is duplicated on this cosmid and shares 74 %25 identity%2C in 65 aa overlap%2C with the downstream gene%2C SC1G2.14c. gene gene2245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2245 SCO2246 SCO2246 SC1G2.08c SC1G2.08c 2415308 2416084 - hypothetical protein SC1G2.08c%2C unknown%2C len: 258 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86676(EMBL:AL031371) SC4G2.03 (277 aa)%2C fasta scores opt: 604 z-score: 734.8 E():0 46.3%25 identity in 229 aa overlap and TR:Q9X8M2(EMBL:AL049628) SCE94.16C (280 aa)%2C fasta scores opt: 469 z-score: 572.0 E(): 1.8e-24 35.2%25 identity in 230 aa overlap. This gene is duplicated on this cosmid and shares 76.1 %25 identity%2C in 259 aa overlap%2C with the downstream gene%2C SC1G2.15c. gene gene2246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2246 SCO2247 SCO2247 SC1G2.09c SC1G2.09c 2416129 2416314 - hypothetical protein SC1G2.09c%2C unknown%2C len: 61 aa. gene gene2247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2247 SCO2248 SCO2248 SC1G2.10 SC1G2.10 2416596 2417093 + hypothetical protein SC1G2.10%2C hypothetical protein%2C len: 165 aa%3B similar to TR:Q9RD82 (EMBL:AL136502) Streptomyces coelicolor hypothetical protein SCF43.06%2C 164 aa%3B fasta scores: opt: 669 Z-score: 833.5 E(): 8.6e-39%3B 60.736%25 identity in 163 aa overlap gene gene2248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2248 SCO2249 SCO2249 SC1G2.11 SC1G2.11 2417492 2417722 + hypothetical protein SC1G2.11%2C unknown%2C len: 76 aa. gene gene2249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2249 SCO2250 SCO2250 SC1G2.12 SC1G2.12 2417879 2418706 + hypothetical protein SC1G2.12%2C unknown%2C len: 275 aa. Weakly similar to a protein of undefined function from Mycobacterium tuberculosis TR:O07720(EMBL:Z97193) hypothetical 26.9 KD protein (250 aa)%2C fasta scores 0pt: 176 z-score: 214.1 E(): 0.00015 28.4%25 identity in 250 aa overlap. gene gene2250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2250 SCO2251 SCO2251 SC1G2.13 SC1G2.13 2418753 2419427 + hypothetical protein SC1G2.13%2C possible integral membrane protein%2C len: 224 aa. Contains multiple possible membrane spanning hydrophobic domains. gene gene2251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2251 SCO2252 SCO2252 SC1G2.14c SC1G2.14c 2419411 2419632 - hypothetical protein SC1G2.14c%2C unknown%2C len: 69 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86600(EMBL:AL031514) SC2H4.17C (81 aa)%2C fasta scores opt: 219 z-score: 324.3 E(): 1.1e-10 64.7%25 identity in 51 aa overlap%2C TR:O86677(EMBL:AL031371) SC4G2.04 (67 aa)%2C fasta scores opt: 184 z-score: 276.9 E(): 4.8e-08 46.0%25 identity in 63 aa overlap and TR:Q9Z544(EMBL:AL035212) SC9B2.15C (77 aa)%2C fasta scores opt: 168 z-score: 253.6 E(): 9.6e-07 51.0%25 identity in 49 aa overlap. Also similar to OrfD located within a novel antibiotic regulatory locus%2C abaA%2C in Streptomyces coelicolor TR:Q53896(EMBL:X60316) (75 aa)%2C fasta scores opt: 124 z-score: 192.5 E(): 0.0024 42.0%25 identity in 50 aa overlap. This gene is duplicated on this cosmid and shares 74 %25 identity%2C in 50 aa overlap%2C with the upstream gene%2C SC1G2.07c. gene gene2252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2252 SCO2253 SCO2253 SC1G2.15c SC1G2.15c 2419629 2420483 - hypothetical protein SC1G2.15c%2C unknown%2C len: 258 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86676(EMBL:AL031371) SC4G2.03 (277 aa)%2C fasta scores opt: 758 z-score: 919.8 E():0 46.7%25 identity in 276 aa overlap and TR:Q9X8M2(EMBL:AL049628) SCE94.16C (280 aa)%2C fasta scores opt: 476 z-score: 580.1 E(): 6.2e-25 32.7%25 identity in 260 aa overlap. This gene is duplicated on this cosmid and shares 76.1 %25 identity%2C in 259 aa overlap%2C with the upstream gene%2C SC1G2.08c. gene gene2253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2253 SCO2254 SCO2254 SC1G2.16c SC1G2.16c 2420563 2421804 - transmembrane efflux protein SC1G2.16c.possible transmembrane efflux protein%2C len: 413 aa. Highly similar to many transmembrane transport proteins e.g. Streptomyces lividans SW:CMLR_STRLI(EMBL:X59968) chloramphenicol resistance protein CmlR (392 aa)%2C fasta scores opt: 743 z-score: 769.2 E():0 35.8%25 identity in 377 aa overlap and Streptomyces coelicolor TR:Q9X8V1(EMBL:AL049826) transmembrane efflux protein SCH24.37 (404 aa)%2C fasta scores opt: 1313 z-score: 1352.1 E(): 0 52.0%25 identity in 408 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and multiple possible membrane spanning hydrophobic domains. gene gene2254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2254 SCO2255 SCO2255 SC1G2.17c SC1G2.17c 2421926 2422978 - hypothetical protein SCC75A.01c%2C possible membrane protein%2C partial CDS%2C len: > 268 aa. Highly similar to another membrane protein from Streptomyces coelicolor TR:CAB45459(EMBL:AL079348) SC66T3.03 (330 aa)%2C fasta scores opt: 695 z-score: 823.4 E():0 54.8%25 identity in 241 aa overlap. Contains possible membrane spanning hydrophobic domains.~SC1G2.17c%2C unknown%2C partial CDS%2C len: > 116 aa. Highly similar to the C-terminus of Streptomyces coelicolor TR:Q9XAL0(EMBL:AL079348) membrane protein SC66T3.03 (330 aa)%2C fasta scores opt: 472 z-score: 600.5 E(): 4.6e-26 66.1%25 identity in 109 aa overlap. gene gene2255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2255 SCO2256 SCO2256 panB panB 2423298 2424173 + 3-methyl-2-oxobutanoate hydroxymethyltransferase catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5%2C10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate gene gene2256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2256 SCO2257 SCO2257 SCC75A.03 SCC75A.03 2424293 2425390 + ABC transporter ATP-binding protein SCC75A.03%2C probable ABC transporter%2C ATP-binding component%2C len: 365 aa. Highly similar to many ABC transporters e.g. Streptomyces peucetius SW:DRRA_STRPE(EMBL:M73758) daunorubicin resistance ATP-binding protein (330 aa)%2C fasta scores opt: 922 z-score: 1009.0 E():0 48.9%25 identity in 329 aa overlap and Streptomyces antibioticus TR:Q53716(EMBL:L06249) ATP-binding protein OLEC-ORF4 involved in oleandomycin-resistance (325 aa)%2C fasta scores opt: 1883 z-score: 2052.8 E():0 89.7%25 identity in 329 aa overlap. Also similar to several Streptomyces coelicolor ABC transporter ATP-binding components e.g TR:CAB42771(EMBL:AL049841) SCE9.25C (315 aa)%2C fasta scores opt: 1031 z-score: 1127.7 E():0 54.4%25 identity in 318 aa overlap. Contains Prosite hits to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene2257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2257 SCO2258 SCO2258 SCC75A.04 SCC75A.04 2425387 2426211 + ABC transporter SCC75A.04%2C probable ABC-transporter%2C transmembrane component%2C len: 274 aa. Similar to many transport proteins including: Streptomyces peucetius SW:DRRB_STRPE(EMBL:M73758) daunorubicin resistance transmembrane protein (283 aa)%2C fasta scores opt: 523 z-score: 593.2 E(): 1.2e-25 35.1%25 identity in 245 aa overlap and Streptomyces antibioticus TR:Q53717(EMBL:L06249) membrane protein OLEC-ORF5 involved in oleandomycin-resistance (273 aa)%2C fasta scores opt: 1502 z-score: 1685.2 E():0 83.2%25 identity in 274 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene2258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2258 SCO2259 SCO2259 SCC75A.05c SCC75A.05c 2426233 2430237 - multidomain-containing protein family SCC75A.05c%2C possible multi-domain regulatory protein%2C len: 1334 aa. Similar in parts to many regulators. Similar in the N-terminus to Streptomyces coelicolor SW:AFSR_STRCO (EMBL:D90155) regulatory protein AfsR (993 aa)%2C fasta scores opt: 524 z-score: 356.0 E(): 1.9e-12 37.0%25 identity in 316 aa overlap. Similar in the C-terminus to many other proposed regulators e.g. Mycobacterium tuberculosis TR:O53720 (EMBL:AL021931) transcriptional regulatory protein (1085 aa)%2C fasta scores opt: 809 z-score: 541.8 E(): 8.3e-23 34.1%25 identity in 883 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a highly degenerate repeat region with 16x PA(P/S)G and 5x APG. This repeat region also has a notably higher GC content (83.4%25). Contains probable coiled-coils between residues 867 to 904 (38 residues) and 1093 to 1121 (29 residues). gene gene2259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2259 SCO2260 SCO2260 SCC75A.06 SCC75A.06 2430388 2431185 + hypothetical protein SCC75A.06%2C possible membrane protein%2C len: 265 aa. Highly similar to a protein of undefined function from Mycobacterium tuberculosis TR:O06309(EMBL:Z95324) (259 aa)%2C fasta scores opt: 646 z-score: 795.3 E():0 42.9%25 identity in 259 aa overlap. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene2260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2260 SCO2261 SCO2261 SCC75A.07c SCC75A.07c 2431192 2431449 - hypothetical protein SCC75A.07c%2C possible membrane protein%2C len: 85 aa. Contains a possible membrane spanning hydrophobic domains. gene gene2261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2261 SCO2262 SCO2262 SCC75A.08c SCC75A.08c 2431446 2432165 - oxidoreductase SCC75A.08c%2C possible oxidoreductase%2C len: 239 aa. Similar to several including: Methanobacterium thermoautotrophicum TR:O59661(EMBL:Y17210) F420-dependent NADP reductase (224 aa)%2C fasta scores opt: 257 z-score: 283.4 E(): 2.1e-08 38.3%25 identity in 222 aa overlap and Archaeoglobus fulgidus TR:O29059(EMBL:AE001021) conserved hypothetical protein (213 aa)%2C fasta scores opt: 397 z-score: 431.0 E(): 1.2e-16 37.3%25 identity in 204 aa overlap. gene gene2262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2262 SCO2263 SCO2263 SCC75A.09 SCC75A.09 2432297 2432911 + hypothetical protein SCC75A.09%2C unknown%2C len: 204 aa. Weakly similar to Streptomyces coelicolor TR:CAB45617(EMBL:AL079356) hypothetical 29.3 KD protein SC6G9.26C (274 aa)%2C fasta scores opt: 125 z-score: 153.0 E(): 0.38 32.8%25 identity in 189 aa overlap. gene gene2263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2263 SCO2264 SCO2264 SCC75A.10 SCC75A.10 2433311 2434606 + hypothetical protein SCC75A.10%2C possible integral membrane protein%2C len: 431 aa. Weakly similar to Mycobacterium smegmatis TR:O31137(EMBL:AF030344) tetracycline-resistance determinant (419 aa)%2C fasta scores opt: 330 z-score: 364.8 E(): 6e-13 24.2%25 identity in 414 aa overlap. Highly similar to Streptomyces coelicolor TR:O69821(EMBL:AL023496) transmembrane protein SC1A6.16 (431 aa)%2C fasta scores opt: 1808 z-score: 1971.5 E():0 64.7%25 identity in 419 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene2264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2264 SCO2265 SCO2265 SCC75A.11c SCC75A.11c 2434607 2434885 - hypothetical protein SCC75A.11c%2C unknown%2C len: 92 aa. gene gene2265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2265 SCO2266 SCO2266 map3 map3 2434908 2435765 + methionine aminopeptidase catalyzes the removal of N-terminal amino acids from peptides and arylamides%3B generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn%2C Fe%2C or Mn gene gene2266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2266 SCO2267 SCO2267 SCC75A.13 SCC75A.13 2435930 2436577 + heme oxygenase SCC75A.13%2C probable heme oxygenase%2C len: 215 aa. Highly similar to many Eukaryotic and several Prokaryotic heme oxygenases including: Gallus gallus (Chicken) SW:HO_CHICK (EMBL:X56201) (296 aa)%2C fasta scores opt: 485 z-score: 601.9 E(): 3.8e-26 37.6%25 identity in 205 aa overlap and Corynebacterium diphtheriae SW:HMUO_CORDI (EMBL:U73860)(215 aa)%2C fasta scores opt: 463 z-score: 577.0 E(): 9.2e-25 41.5%25 identity in 205 aa overlap. Contains a Pfam match to entry PF01126 Heme_oxygenase%2C Heme oxygenase. gene gene2267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2267 SCO2268 SCO2268 SCC75A.14c SCC75A.14c 2436593 2437237 - hypothetical protein SCC75A.14c%2C unknown%2C len: 214 aa. Highly similar to Mycobacterium tuberculosis SW:YR16_MYCTU (EMBL:Z96072) hypothetical 24.6 KD protein (228 aa)%2C fasta scores: opt: 447 z-score: 555.4 E(): 1.5e-23 44.1%25 identity in 220 aa overlap and to the C-terminus of Mycobacterium tuberculosis SW:TYSY_MYCTU (EMBL:X59273) thymidylate synthase (EC 2.1.1.45) (450 aa)%2C fasta scores opt: 447 z-score: 550.9 E(): 2.6e-23 44.1%25 identity in 220 aa overlap gene gene2268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2268 SCO2269 SCO2269 SCC75A.15c SCC75A.15c 2437246 2438073 - hypothetical protein SCC75A.15c%2C unknown%2C len: 275 aa. gene gene2269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2269 SCO2270 SCO2270 SCC75A.16c SCC75A.16c 2438127 2439746 - hypothetical protein SCC75A.16c%2C possible membrane protein%2C len: 539 aa. Contains a possible N-terminal signal sequence%2C a possible membrane spanning hydrophobic domain and is rich in amino acids Ala%2C Gly and Thr. gene gene2270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2270 SCO2271 SCO2271 SCC75A.17c SCC75A.17c 2439787 2441220 - hypothetical protein SCC75A.17c%2C possible membrane protein%2C len: 539 aa. Contains a possible N-terminal signal sequence%2C a possible membrane spanning hydrophobic domain and is rich in the amino acid Ala. gene gene2271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2271 SCO2272 SCO2272 SCC75A.18 SCC75A.18 2441324 2442376 + binding-protein-dependent transport lipoprotein SCC75A.18%2C binding-protein-dependent transport lipoprotein%2C len: 350 aa. Similar to many proteins involved in iron acquisition including: Yersinia pestis SW:HMUT_YERPE(EMBL:U60647) hemin-binding periplasmic protein HmuT precursor (278 aa)%2C fasta scores opt: 462 z-score: 474.0 E(): 5e-19 33.3%25 identity in 258 aa overlap and Corynebacterium diphtheriae TR:AAD37493(EMBL:AF109162) probable lipoprotein heme receptor HmuT (353 aa)%2C fasta scores opt: 670 z-score: 680.9 E(): 1.5e-30 37.2%25 identity in 339 aa overlap. Contains a Pfam match to entry PF01497 Peripla_BP_2%2C Periplasmic binding protein and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a possible N-terminal signal sequence. gene gene2272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2272 SCO2273 SCO2273 SCC75A.19 SCC75A.19 2442373 2443464 + FecCD-family membrane transport protein SCC75A.19%2C FecCD-family membrane transport protein%2C len: 363 aa. Highly similar to proteins involved in iron acquisition including: Yersinia pestis SW:HMUU_YERPE(EMBL:U60647) hemin transport system permease HmuU (334 aa)%2C fasta scores: opt: 855 z-score: 924.4 E():0 45.9%25 identity in 290 aa overlap and Corynebacterium diphtheriae TR:AAD37494(EMBL:AF109162) BC-type transporter permease (350 aa)%2C fasta scores opt: 1006 z-score: 1085.8 E():0 47.2%25 identity in 339 aa overlap. Contains a Pfam match to entry PF01032 FecCD_family%2C FecCD transport family and multiple possible membrane spanning hydrophobic domains. gene gene2273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2273 SCO2274 SCO2274 hmuV hmuV 2443461 2444303 + hemin importer ATP-binding subunit with HmuTU is involved in the transport of hemin gene gene2274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2274 SCO2275 SCO2275 SCC75A.21 SCC75A.21 2444536 2445690 + lipoprotein SCC75A.21%2C possible lipoprotein%2C len: 384 aa. Similar to several proteins of undefined function including: Escherichia coli TR:BAA35799(EMBL:D90739) (362 aa)%2C fasta scores opt: 783 z-score: 851.0 E():0 39.2%25 identity in 365 aa overlap and Bacillus subtilis SW:YWBM_BACSU(EMBL:X73124) (385 aa)%2C fasta scores opt: 675 z-score: 734.3 E():0 34.9%25 identity in 387 aa overlap. Contains a N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene2275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2275 SCO2276 SCO2276 SCC75A.22 SCC75A.22 2445705 2446967 + hypothetical protein SCC75A.22%2C possible membrane protein%2C len: 420 aa. Similar to several proteins of undefined function including: Bacillus subtilis SW:YWBN_BACSU(EMBL:X73124) (416 aa)%2C fasta scores opt: 1076 z-score: 1183.4 E(): 0 42.7%25 identity in 405 aa overlap and Streptomyces coelicolor TR:Q9ZBW9(EMBL:AL034355) SCD78.30c (445 aa)%2C fasta scores opt:584 z-score: 643.8 E(): 1.7e-28 43.2%25 identity in 428 aa overlap. Contains a possible N-terminal membrane spanning hydrophobic domain. gene gene2276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2276 SCO2277 SCO2277 SCC75A.23 SCC75A.23 2446970 2447842 + hypothetical protein SCC75A.23%2C possible membrane protein%2C len: 290 aa. Highly similar to many proteins of undefined function including: Escherichia coli SW:YCDN_ECOLI(EMBL:AE000203) YcdN (276 aa)%2C fasta scores opt: 693 z-score: 817.1 E():0 41.6%25 identity in 267 aa overlap and Synechocystis sp. (strain PCC 6803) SW:Y964_SYNY3(EMBL:D90901) (308 aa)%2C fasta scores opt: 363 z-score: 431.0 E(): 1.2e-16 30.4%25 identity in 303 aa overlap gene gene2277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2277 SCO2278 SCO2278 SCC75A.24 SCC75A.24 2447904 2448791 + hypothetical protein SCC75A.24%2C unknown%2C len: 295 aa. gene gene2278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2278 SCO2279 SCO2279 SCC75A.25c SCC75A.25c 2448807 2449538 - hypothetical protein SCC75A.25c%2C unknown%2C len: 243 aa. gene gene2279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2279 SCO2280 SCO2280 SCC75A.26c SCC75A.26c 2449644 2450291 - TetR family transcriptional regulator SCC75A.26c%2C possible TetR-family transcriptional regulator%2C len: 215 aa. Similar to several other regulators including: Pseudomonas fluorescens TR:AAD31815(EMBL:AF129856) transcriptional regulatory protein PhlF (208 aa)%2C fasta scores opt: 198 z-score: 248.3 E(): 1.9e-06 25.9%25 identity in 158 aa overlap and Streptomyces coelicolor TR:CAB56137(EMBL:AL117669) transcriptional regulator SCF12.11 (206 aa)%2C fasta scores opt: 309 z-score: 381.8 E(): 6.8e-14 30.5%25 identity in 213 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 48..69. gene gene2280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2280 SCO2281 SCO2281 SCC75A.27c SCC75A.27c 2450354 2451040 - two-component system response-regulator SCC75A.27c%2C possible two-component system response-regulator%2C len: 228 aa. Similar to many other regulators including: Rhodococcus sp TR:O85372(EMBL:AF064700) two-component regulator CprR (212 aa)%2C fasta scores opt: 295 z-score: 351.2 E(): 3.5e-12 31.5%25 identity in 203 aa overlap and Streptomyces coelicolor TR:CAB50960(EMBL:AL096849) two-component system response regulator SCI11.34 (221 aa)%2C fasta scores opt: 336 z-score: 398.1 E(): 8.4e-15 34.4%25 identity in 224 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. gene gene2281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2281 SCO2282 SCO2282 SCC75A.28c SCC75A.28c 2451048 2452028 - hypothetical protein SCC75A.28c%2C hypothetical protein%2C len: 326 aa%3B similar to TR:Q984U3 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) MLL7840 protein 323 aa%3B fasta scores: opt: 712 Z-score: 794.8 E(): 1.2e-36%3B 38.365%25 identity in 318 aa overlap gene gene2282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2282 SCO2283 SCO2283 SCC75A.29c SCC75A.29c 2452574 2453629 - esterase SCC75A.29c%2C possible esterase%2C len: 351 aa. Similar%2C in parts%2C to several esterases e.g. Pseudomonas sp. TR:Q52467(EMBL:M68491) esterase (389 aa)%2C fasta scores opt: 256 z-score: 289.8 E(): 9.2e-09 30.3%25 identity in 323 aa overlap. Also similar%2C in parts%2C to several penicillin-binding proteins e.g. Nocardia lactamdurans SW:PBP4_NOCLA (EMBL:Z13972) penicillin-binding protein 4 (PBP-4) (381 aa)%2C fasta scores opt: 249 z-score: 282.1 E(): 2.4e-08 29.2%25 identity in 308 aa overlap. Contains a possible N-terminal signal sequence. gene gene2283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2283 SCO2284 SCO2284 SCC75A.30c SCC75A.30c 2453707 2454993 - membrane transport protein SCC75A.30c%2C possible membrane transport protein%2C len: 428 aa. Similar to many members of the drug resistance translocase family including: Escherichia coli SW:BCR_ECOLI(EMBL:X63703) bicyclomycin resistance protein (sulfonamide resistance protein) (396 aa)%2C fasta scores opt: 767 z-score: 825.5 E():0 33.9%25 identity in 395 aa overlap and Bacillus subtilis TR:P96709(EMBL:AB001488) bicyclomycin resistance protein YdgK (402 aa)%2C fasta scores opt: 1073 z-score: 1151.7 E():0 42.3%25 identity in 397 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and a Prosite hit to PS00216 Sugar transport proteins signature 1. Also contains multiple possible membrane spanning hydrophobic domains. gene gene2284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2284 SCO2285 SCO2285 SCC75A.31 SCC75A.31 2455103 2456158 + oxidoreductase SCC75A.31%2C possible oxidoreductase%2C len: 351 aa. Similar to many Eukaryotic dimeric dihydrodiol dehydrogenases e.g. Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) TR:BAA83489(EMBL:AB021932) dimeric dihydrodiol dehydrogenase (EC 1.3.1.20) (334 aa)%2C fasta scores opt: 741 z-score: 868.2 E():0 39.1%25 identity in 335 aa overlap. Also similar to Prokaryotic oxidoreductases e.g. Streptomyces antibioticus TR:AAD55450(EMBL:AF055579) 3-ketoreductase (328 aa)%2C fasta scores opt: 434 z-score: 510.8 E(): 4.5e-21 34.0%25 identity in 300 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene2285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2285 SCO2286 SCO2286 SCC75A.32c SCC75A.32c 2456145 2457821 - alkaline phosphatase SCC75A.32c%2C possible alkaline phosphatase%2C len: 558 aa. Highly similar to alkaline phosphatases from Bacillus subtilis SW:PPBD_BACSU (EMBL:U49060) alkaline phosphatase D precursor (EC 3.1.3.1) (556 aa)%2C fasta scores opt: 1652 z-score: 1864.2 E():0 49.6%25 identity in 488 aa overlap. Also similar to several from Streptomyces coelicolor: EMBL:AL096837 alkaline phosphatase SCF43A.18 (553 aa)%2C fasta scores opt: 2452 z-score: 2273.5 E():0 65.0%25 identity in 552 aa overlap and TR:CAB51460 (EMBL:AL096884) alkaline phosphatase (551 aa)%2C fasta scores opt: 928 z-score: 1047.4 E(): 0 38.5%25 identity in 556 aa overlap. Contains possible hydrophobic membrane spanning region gene gene2286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2286 SCO2287 SCO2287 SCC75A.33 SCC75A.33 2457954 2458745 + oxidoreductase SCC75A.33%2C possible oxidoreductase%2C len: 263 aa. Similar to several including: Bacillus megaterium SW:DHG2_BACME (EMBL:D90044) glucose 1-dehydrogenase II (EC 1.1.1.47) (261 aa)%2C fasta scores opt: 400 z-score: 442.6 E(): 2.8e-17 38.9%25 identity in 193 aa overlap SW:YOHF_ECOLI (EMBL:U00007) hypothetical oxidoreductase (253 aa)%2C fasta scores opt: 422 z-score: 466.5 E(): 1.3e-18 38.3%25 identity in 206 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene2287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2287 SCO2288 SCO2288 SCC75A.34c SCC75A.34c 2459004 2459330 - hypothetical protein SCC75A.34c%2C unknown%2C len: 108 aa. Similar to Streptomyces coelicolor TR:CAB58302(EMBL:AL121854) hypothetical 11.8 KD protein (106 aa)%2C fasta scores opt:99 z-score: 145.3 E():0.96 31.2%25 identity in 93 aa overlap. gene gene2288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2288 SCO2289 SCO2289 SCC75A.35 SCC75A.35 2459484 2460026 + hypothetical protein SCC75A.35%2C possible membrane protein%2C len: 180 aa. Similar to several proteins of undefined function including: Bacillus subtilis TR:P96694(EMBL:AB001488) YdfP protein (129 aa)%2C fasta scores opt: 308 z-score: 319.7 E(): 2e-10 42.4%25 identity in 125 aa overlap and Mycobacterium tuberculosis TR:O53252(EMBL:AL021287) (279 aa)%2C fasta scores opt: 328 z-score: 335.2 E(): 2.7e-11 43.5%25 identity in 147 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene2289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2289 SCO2290 SCO2290 SCC75A.36 SCC75A.36 2460057 2460398 + hypothetical protein SCC75A.36%2C unknown%2C len: 113 aa. Weakly similar to Bacillus subtilis SW:YPJD_BACSU(EMBL:L38424) hypothetical 13.0 KD protein (111 aa)%2C fasta scores opt:103 z-score: 145.9 E():0.94 30.8%25 identity in 91 aa overlap. gene gene2290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2290 SCO2291 SCO2291 axeA axeA 2460463 2461470 - acetylxylan esterase SCC75A.37%2C axeA%2C acetylxylan esterase%2C len: 335 aa. Almost identical in sequence with Streptomyces lividans TR:Q54413 (EMBL:M64552) acetylxylan esterase precursor (EC 3.1.1.72) (335 aa)%2C fasta scores opt: 2197 z-score: 2058.4 E(): 0 98.5%25 identity in 335 aa overlap. Also highly similar to the C-terminus of Cellulomonas fimi SW:XYND_CELFI (EMBL:X76729) endo-1%2C4-beta-xylanase D precursor (EC 3.2.1.8) (644 aa)%2C fasta scores opt: 1108 z-score: 1040.5 E(): 0 50.0%25 identity in 346 aa overlap. Also similar to the adjoining CDS on this cosmid%2C xlnB%2C (335 aa)%2C fasta scores opt: 652 z-score: 554.2 E(): 1.7e-25 56.2%25 identity in 201 aa overlap. Contains a possible N-terminal signal sequence and a Pfam match to entry PF01522 Polysac_deacet%2C Polysaccharide deacetylase gene gene2291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2291 SCO2292 SCO2292 xlnB xlnB 2461505 2462512 - endo-1%2C4-beta-xylanase B SCC75A.38%2C xlnB%2C endo-1%2C4-beta-xylanase B (xylanase B)%2C len: 335 aa. Almost identical to Streptomyces lividans SW:XYNB_STRLI(EMBL:M64552) endo-1%2C4-beta-xylanase B precursor (xylanase B) (EC 3.2.1.8) (334 aa)%2C fasta scores opt: 2266 z-score: 2249.3 E():0 98.2%25 identity in 335 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52919 (EMBL:AL109949) endo-1%2C4-beta-xylanase%2C XlnC (241 aa)%2C fasta scores opt: 1087 z-score: 970.6 E():0 71.9%25 identity in 224 aa overlap and to the adjoining CDS on this cosmid%2C AxeA%2C (335 aa)%2C fasta scores opt: 652 z-score: 585.8 E(): 2.9e-27 56.2%25 identity in 201 aa overlap. Contains a N-terminal signal sequence%2C Prosite hits to PS00776 Glycosyl hydrolases family 11 active site signature 1 and PS00777 Glycosyl hydrolases family 11 active site signature 2%2C as well as a Pfam match to entry PF00457 Glyco_hydro_11%2C Glycosyl hydrolases family 11. gene gene2292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2292 SCO2293 SCO2293 SCC30.01c SCC30.01c 2463222 2464202 - hypothetical protein SCC30.01c%2C possible integral membrane protein%2C len: 326 aa%3B similar to TR:BAA87714 (EMBL:AB016260) Agrobacterium tumefaciens TIORF89 protein%2C 306 aa%3B fasta scores: opt: 396 z-score: 465.4 E(): 1.8e-18%3B 28.7%25 identity in 286 aa overlap. Contains 2x Pfam match to entry PF00892 DUF6%2C Integral membrane protein and possible hydrophobic membrane spanning regions gene gene2294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2293 SCO2294 SCO2294 SCC30.02c SCC30.02c 2464222 2465058 - AraC family transcription regulator SCC30.02c%2C probable araC-family regulatory protein%2C len: 278 aa%3B similar to SW:ARAC_SALTY (EMBL:J01797) Salmonella typhimurium arabinose operon regulatory protein AraC%2C 281 aa%3B fasta scores: opt: 232 z-score: 270.4 E(): 1.3e-07%3B 26.7%25 identity in 270 aa overlap and to various Streptomyces coelicolor araC-family transcriptional regulators%2C e.g. TR:O50480 (EMBL:AL031031) S. coelicolor transcriptional regulator SC7C7.17 (SC4H8.01)%2C 288 aa%3B fasta scores: opt: 638 z-score: 605.1 E(): 3.3e-28%3B 43.8%25 identity in 292 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and possible helix-turn-helix motif at residues 189..210 (+3.81 SD) gene gene2295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2294 SCO2295 SCO2295 SCC30.03 SCC30.03 2465169 2465930 + hypothetical protein SCC30.03%2C hypothetical protein%2C len: 253 aa%3B N-terminal region similar to TR:CAB52842 (EMBL:AL109848) Streptomyces coelicolor transcriptional regulator SCI51.18%2C 548 aa%3B fasta scores: opt: 114 z-score: 134.1 E(): 5%3B 30.6%25 identity in 196 aa overlap. Contains possible coiled-coil region at aprox residues 76..93 gene gene2296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2295 SCO2296 SCO2296 SCC30.04 SCC30.04 2465927 2466541 + hypothetical protein SCC30.04%2C possible integral membrane protein%2C len: 204 aa%3B similar to TR:AAF12504 (EMBL:AE001863) Deinococcus radiodurans hypothetical 32.0 kD protein%2C 289 aa%3B fasta scores: opt: 178 z-score: 231.0 E(): 2e-05%3B 29.8%25 identity in 161 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2296 SCO2297 SCO2297 SCC30.05 SCC30.05 2466581 2467363 + hypothetical protein SCC30.05%2C hypothetical protein%2C len: 260 aa%3B similar to SW:YHI3_CAMJE (EMBL:Z36940) Campylobacter jejuni hypothetical 28.7 kD protein in HipO 3'region%2C 246 aa%3B fasta scores: opt: 245 z-score: 295.9 E(): 4.9e-09%3B 28.1%25 identity in 210 aa overlap gene gene2298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2297 SCO2298 SCO2298 kdgA kdgA 2467437 2468096 + KHG/KDPG aldolase SCC30.06%2C kdgA%2C KHG/KDPG aldolase%2C len: 219 aa%3B highly similar to SW:ALKH_ECOLI (EMBL:X68871) Escherichia coli KHG/KDPG aldolase [includes: 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) (2-keto-4-hydroxyglutarate aldolase) (KHG-aldolase)%3B 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) (phospho-2-dehydro-3-deoxygluconate aldolase) (phospho-2-keto-3-deoxygluconate aldolase) (2-keto-3-deoxy-6-phosphogluconate aldolase) (KDPG-aldolase)] KdgA%2C 213 aa%3B fasta scores: opt: 757 z-score: 811.9 E(): 0%3B 55.0%25 identity in 202 aa overlap. Contains Pfam match to entry PF01081 Aldolase%2C KDPG and KHG aldolase and matches to Prosite entries PS00159 KDPG and KHG aldolases active site and PS00160 KDPG and KHG aldolases Schiff-base forming residue gene gene2299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2298 SCO2299 SCO2299 SCC30.07c SCC30.07c 2468071 2469564 - bifunctional RNase H/acid phosphatase SCC30.07c%2C possible bifunctional protein (ribonuclease H/phosphoglycerate mutase)%2C len: 497 aa%3B N-terminal region similar to TR:Q9X7R6 (EMBL:AL049863) Streptomyces coelicolor ribonuclease H SC5H1.08c%2C 235 aa%3B blastp scores: Score %3D 185 (65.1 bits)%2C Expect %3D 9.5e-14%2C P %3D 9.5e-14 Identities %3D 82/230 (35%25)%2C Positives %3D 105/230 (45%25) and C-terminal region similar to TR:O67797 (EMBL:AE000766) Aquifex aeolicus phosphoglycerate mutase PgmA%2C 212 aa%3B fasta scores: opt: 355 z-score: 327.3 E(): 8.7e-11%3B 32.8%25 identity in 201 aa overlap. Contains Pfam match to entry PF00075 rnaseH%2C RNase H and PF00300 PGAM%2C Phosphoglycerate mutase family gene gene2300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2299 SCO2300 SCO2300 SCC30.08c SCC30.08c 2469576 2470166 - hypothetical protein SCC30.08c%2C hypothetical protein%2C len: 196 aa%3B similar to SW:Y01A_MYCTU (EMBL:Z70692) Mycobacterium tuberculosis hypothetical 26.9 kD protein MTCY427.10c%2C 245 aa%3B fasta scores: opt: 375 z-score: 404.1 E(): 4.6e-15%3B 37.5%25 identity in 176 aa overlap. Contains possible colied-coil region at aprox residues 56..112 gene gene2301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2300 SCO2301 SCO2301 SCC30.09c SCC30.09c 2470316 2471173 - hypothetical protein SCC30.09c%2C hypothetical protein%2C len: 285 aa%3B similar to TR:O69481 (EMBL:AL023635) Mycobacterium leprae hypothetical 40.3 kD protein MLCB1243.36%2C 385 aa%3B fasta scores: opt: 414 z-score: 484.0 E(): 1.7e-19%3B 34.9%25 identity in 370 aa overlap. Contains Pfam match to entry PF01784 DUF34%2C Domain of unknown function gene gene2302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2301 SCO2302 SCO2302 SCC30.10 SCC30.10 2471382 2472650 + hypothetical protein SCC30.10%2C unknown%2C len: 422 aa. High content in glycine%2C alanine and proline amino acid residues gene gene2303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2302 SCO2303 SCO2303 SCC30.11 SCC30.11 2472748 2472915 + hypothetical protein SCC30.11%2C unknown%2C len: 55 aa gene gene2304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2303 SCO2304 SCO2304 SCC30.12c SCC30.12c 2473023 2474024 - dehydrogenase SCC30.12c%2C possible dehydrogenase%2C len: 333 aa%3B similar to SW:DHB4_HUMAN (EMBL:X87176) Homo sapiens%2C estradiol 17 beta-dehydrogenase 4 (EC 1.1.1.62) Hsd17b4%2C 736 aa%3B fasta scores: opt: 611 z-score: 633.2 E(): 8e-28%3B 34.7%25 identity in 288 aa overlap. Contains Pfam match to entry PF01575 MaoC_like%2C MaoC like domain gene gene2305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2304 SCO2305 SCO2305 SCC30.13 SCC30.13 2474063 2474989 + ABC transporter ATP-binding protein SCC30.13%2C probable ABC transporter ATP-binding subunit%2C len: 308 aa%3B similar to TR:AAF12291 (EMBL:AE001862) Deinococcus radiodurans ABC transporter%2C ATP-binding protein%2C %2C DRA0007%2C 301 aa%3B fasta scores: opt: 753 z-score: 842.3 E(): 0%3B 47.9%25 identity in 288 aa overlap and to SW:NODI_RHILO (EMBL:X55705) Rhizobium loti nodulation ATP-binding protein I%2C NodI%2C 339 aa%3B fasta scores: opt: 576 z-score: 645.7 E(): 1.6e-28%3B 37.3%25 identity in 303 aa overlap. Also similar to various Streptomyces coelicolor ABC transporter ATP-binding proteins%2C e.g. TR:CAB56355 (EMBL:AL118514) S. coelicolor ABC transporter%2C ATP-binding subunit SCD25.11c%2C 326 aa%3B fasta scores: opt: 606 z-score: 418.1 E(): 8.6e-18%3B 41.6%25 identity in 296 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene2306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2305 SCO2306 SCO2306 SCC30.14 SCC30.14 2474986 2475702 + ABC transporter SCC30.14%2C probable ABC transporter integral membrane protein%2C len: 238 aa%3B similar to TR:Q9XAC7 (EMBL:AL096839) Streptomyces coelicolor integral membrane transport protein SCC22.11%2C 269 aa%3B fasta scores: opt: 219 z-score: 253.7 E(): 1.1e-06%3B 30.1%25 identity in 239 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2306 SCO2307 SCO2307 SCC30.15 SCC30.15 2475740 2476969 + two-component sensor kinase SCC30.15%2C possible two-component sensor kinase%2C len: 409 aa%3B similar to TR:Q9ZA46 (EMBL:AJ011500) Streptomyces violaceoruber two-component sensor kinase GRA-ORF11%2C 406 aa%3B fasta scores: opt: 460 z-score: 493.4 E(): 4.9e-20%3B 33.3%25 identity in 402 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2307 SCO2308 SCO2308 SCC30.16 SCC30.16 2477055 2477687 + two-component system response regulator SCC30.16%2C probable two-component system response regulator%2C len: 235 aa%3B similar to TR:Q9ZA47 (EMBL:AJ011500) Streptomyces violaceoruber two-component response regulator GRA-ORF10%2C 202 aa%3B fasta scores: opt: 711 z-score: 821.6 E(): 0%3B 55.0%25 identity in 200 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains also possible helix-turn-helix motif at residues 190..211 (+4.76 SD) gene gene2309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2308 SCO2309 SCO2309 SCC30.17c SCC30.17c 2478172 2479641 - transmembrane transport protein SCC30.17c%2C probable transmembrane transport protein%2C len: 489 aa%3B similar to TR:Q9WVV3 (EMBL:AF127374) Streptomyces lavendulae Mtc%2C 484 aa%3B fasta scores: opt: 1680 z-score: 1711.3 E(): 0%3B 54.7%25 identity in 475 aa overlap and to SW:CMCT_NOCLA (EMBL:Z13973) Nocardia lactamdurans cephamycin export protein CmcT%2C 486 aa%3B fasta scores: opt: 1334 z-score: 1360.2 E(): 0%3B 48.3%25 identity in 480 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2309 SCO2310 SCO2310 SCC30.18 SCC30.18 2479917 2481674 + integral membrane efflux protein SCC53.01%2C possible integral membrane efflux protein%2C partial CDS%2C len: 277aa%3B similar to C-terminus of many eg. TR:Q9ZBJ1 (EMBL:AL035161) efflux protein from Streptomyces coelicolor (815 aa) fasta scores%3B opt: 249%2C z-score: 264.8%2C E(): 2.8e-07%2C 29.9%25 identity in 314 aa overlap and SW:P39886 (TCMA_STRGA) tetracenomycin c resistance and export protein from Streptomyces glaucescens (538 aa) fasta scores%3B opt: 197%2C z-score: 213.0%2C E(): 0.00022%2C 30.1%25 identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions.~SCC30.18%2C probable transport protein (fragment)%2C len: >348 aa%3B similar to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA%2C 538 aa%3B fasta scores: opt: 447 z-score: 504.9 E(): 1.1e-20%3B 27.7%25 identity in 361 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2310 SCO2311 SCO2311 SCC53.02 SCC53.02 2481918 2483546 + hypothetical protein SCC53.02%2C unknown%2C len: 542aa%3B contains possible stem loop in the 3' end of the CDS. gene gene2312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2311 SCO2312 SCO2312 SCC53.03 SCC53.03 2483562 2484278 + hypothetical protein SCC53.03%2C hypothetical protein%2C len: 238 aa. Contains possible N-terminal region signal peptide sequence gene gene2313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2312 SCO2313 SCO2313 SCC53.04 SCC53.04 2484289 2485299 + hypothetical protein SCC53.04%2C possible membrane protein%2C len: 336aa%3B similar to TR:O69684 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (241 aa) fasta scores%3B opt: 536%2C z-score: 436.5%2C E(): 7.6e-17%2C 41.2%25 identity in 233 aa overlap. Contains Pfam match to entry PF01520 Amidase_3%2C N-acetylmuramoyl-L-alanine amidase and possible hydrophobic membrane spanning region gene gene2314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2313 SCO2314 SCO2314 SCC53.05 SCC53.05 2485458 2486327 + hypothetical protein SCC53.05%2C possible integral membrane protein%2C len: 289 aa%3B contains possible membrane-spanning hydrophobic regions. Also contains Gly/Pro/Gln-rich region 160-220aa. gene gene2315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2314 SCO2315 SCO2315 SCC53.06 SCC53.06 2486429 2486722 + hypothetical protein SCC53.06%2C possible membrane protein%2C len: 97aa%3B contains possible membrane-spanning hydrophobic regions. gene gene2316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2315 SCO2316 SCO2316 SCC53.07c SCC53.07c 2486736 2487833 - hypothetical protein SCC53.07c%2C unknown%2C len: 365aa gene gene2317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2316 SCO2317 SCO2317 SCC53.08c SCC53.08c 2487830 2488564 - methyltransferase SCC53.08c%2C possible methyltransferase%2C len: 244 aa%3B region similar to many methyltransferases e.g. TR:O82720 (EMBL:U81312) S-adenosyl-methionine-sterol-C-methyltransferase from Nicotiana tabacum (Common tobacco) (346 aa) fasta scores%3B opt: 228%2C z-score: 285.6%2C E(): 1.9e-08%2C 33.1%25 identity in 139 aa overlap. gene gene2318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2317 SCO2318 SCO2318 SCC53.09c SCC53.09c 2488558 2490054 - glycosyl transferase SCC53.09c%2C possible glycosyl transferase%2C len: 498 aa%3B similar to many e.g. TR:Q00481 (EMBL:X61917) second mannosyl transferase from Salmonella enterica (336 aa) fasta scores%3B opt: 325%2C z-score: 324.2%2C E(): 1.4e-10%2C 30.9%25 identity in 259 aa overlap and TR:Q9Z5B7 (EMBL:AL035478) transferase from Streptomyces coelicolor (406 aa) fasta scores%3B opt: 398%2C z-score: 393.8 %2CE(): 1.8e-14%2C 32.4%25 identity in 454 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1. gene gene2319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2318 SCO2319 SCO2319 SCC53.10 SCC53.10 2490169 2490921 + TetR family transcriptional regulator SCC53.10%2C possible tetR-family regulatory protein%2C len: 250 aa%3B regions similar to many proposed regulatory proteins e.g. TR:P96856 (EMBL:Z92774) hypothetical protein from Mycobacterium tuberculosis (199 aa) fasta scores%3B opt: 492%2C z-score: 572.6%2C E(): 2e-24%2C 44.8%25 identity in 183 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene2320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2319 SCO2320 SCO2320 SCC53.11c SCC53.11c 2490934 2491818 - hypothetical protein SCC53.11c%2C hypothetical protein%2C len: 294 aa%3B similar to regions from many larger proteins eg. TR:O54230 (EMBL:AJ000264) protein kinase (EC 2.7.1.37) from Streptomyces granaticolor (701 aa) fasta scores%3B opt: 160%2C z-score: 170.0%2C E(): 0.054%2C 29.5%25 identity in 190 aa overlap and SW:P54739 (PKAA_STRCO) Ser/Thr protein kinase PkaA from Streptomyces coelicolor (543 aa) fasta scores%3B opt: 129%2C z-score: 139.5%2C E(): 2.7%2C 31.7%25 identity in 139 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation. gene gene2321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2320 SCO2321 SCO2321 SCC53.12 SCC53.12 2491926 2493185 + hypothetical protein SCC53.12%2C possible hypothetical protein%2C len: 419aa%3B contains possible cleavable N-terminal signal sequence and Pfam match to entry PF00432 prenyltrans%2C Prenyltransferase and squalene oxidase repeat. gene gene2322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2321 SCO2322 SCO2322 SCC53.13 SCC53.13 2493182 2493844 + hypothetical protein SCC53.13%2C possible hypothetical protein%2C len: 220aa%3B contains possible cleavable N-terminal signal sequence. gene gene2323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2322 SCO2323 SCO2323 SCC53.14 SCC53.14 2493924 2495063 + hypothetical protein SCC53.14%2C possible integral membrane protein%2C len: 379aa%3B contains possible membrane-spanning hydrophobic regions. gene gene2324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2323 SCO2324 SCO2324 SCC53.15 SCC53.15 2495060 2496751 + ABC transporter ATP-binding protein SCC53.15%2C possible ABC transporter ATP-binding subunit%2C len: 563aa%3B similar to many eg. TR:Q9V1Q4 (EMBL:AJ248284) ABC transporter%2C ATP-binding protein from Pyrococcus abyssi (280 aa) fasta scores%3B opt: 544%2C z-score: 493.5%2C E(): 5.1e-20%2C 40.4%25 identity in 230 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter%2C two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature. gene gene2325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2324 SCO2325 SCO2325 SCC53.16 SCC53.16 2496748 2497599 + hypothetical protein SCC53.16%2C possible integral membrane protein%2C len: 283aa%3B contains possible membrane-spanning hydrophobic regions. gene gene2326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2325 SCO2326 SCO2326 SCC53.17 SCC53.17 2497804 2498268 + hypothetical protein SCC53.17%2C hypothetical protein%2C len: 154 aa%3B similar to the C-terminal region of TR:Q9FBP7 (EMBL:AL391754) Streptomyces coelicolor hypothetical protein SCK7.02%2C 238 aa%3B fasta scores: opt: 477 Z-score: 516.1 bits: 102.2 E(): 4.1e-21%3B 64.356%25 identity (65.000%25 ungapped) in 101 aa overlap gene gene2327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2326 SCO2327 SCO2327 SCC53.18c SCC53.18c 2498289 2498675 - hypothetical protein SCC53.18c%2C unknown%2C len: 128aa%3B strongly similar to TR:CAB82885 (EMBL:AJ276673) from plasmid pSCP1 from Streptomyces coelicolor (128 aa) fasta scores%3B opt: 395%2C z-score: 534.6%2C E(): 2.6e-22%2C 51.6%25 identity in 128 aa overlap. gene gene2328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2327 SCO2328 SCO2328 SCC53.19 SCC53.19 2498914 2499570 + dipeptidase SCC53.19%2C possible dipeptidase%2C len: 218aa%3B similar to TR:Q9R6S5 (EMBL:Y18874) hypothetical 26.3 kD protein from Synechococcus PCC6301 (232 aa) fasta scores%3B opt: 258%2C z-score: 323.7%2C E(): 1.5e-10%2C 30.8%25 identity in 227 aa overlap and SW:Q06241 (VANX_ENTFC) D-alanyl-D-alanine dipeptidase (vancomycin resistance protein) (EC 3.4.13.-) from Enterococcus faecium (202 aa) fasta scores%3B opt: 173%2C z-score: 220.5%2C E(): 8.3e-05%2C 33.1%25 identity in 136 aa overlap. Contains Pfam match to entry PF01427 Peptidase_M45%2C D-ala-D-ala dipeptidase. gene gene2329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2328 SCO2329 SCO2329 SCC53.20c SCC53.20c 2499573 2500535 - transcriptional regulator SCC53.20c%2C possible transcriptional regulator%2C len: 320aa%3B similar to many eg. TR:Q9S166 (EMBL:AB023785) AdpA transcriptional activator for StrR from Streptomyces griseus (405 aa) fasta scores%3B opt: 502%2C z-score: 592.7%2C E(): 1.5e-25%2C 32.6%25 identity in 319 aa overlap and TR:Q9X7Q2 (EMBL:AL049587) transcriptional regulator from Streptomyces coelicolor (325 aa) fasta scores%3B opt: 772%2C z-score: 909.9%2C E(): 0%2C 47.5%25 identity in 318 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C Pfam match to entry PF01965 ThiJ%2C ThiJ/PfpI family and Prosite match to PS00041 Bacterial regulatory proteins%2C araC family signature. gene gene2330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2329 SCO2330 SCO2330 SCC53.21 SCC53.21 2500697 2501287 + isochorismatase SCC53.21%2C possible isochorismatase%2C len: 196 aa%3B region similar to many eg. SW:P15048 (ENTB_ECOLI) isochorismatase (EC 3.3.2.1) from Escherichia coli (285 aa) fasta scores%3B opt: 123%2C z-score: 154.2%2C E(): 0.41%2C 28.9%25 identity in 114 aa overlap. Also similar to TR:P96654 (EMBL:AB001488) hypothetical protein from Bacillus subtilis (180 aa) fasta scores%3B opt: 358%2C z-score: 433.4%2C E(): 1.1e-16%2C 36.7%25 identity in 177 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family. gene gene2331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2330 SCO2331 SCO2331 SCC53.22c SCC53.22c 2501284 2501697 - MarR family transcriptional regulator SCC53.22c%2C possible MarR-family transcriptional regulator%2C len: 137 aa%3B similar to many e.g. SW:Q10810 (YX18_MYCTU) hypothetical transcriptional regulator CY274.18 from Mycobacterium tuberculosis (139 aa) fasta scores%3B opt: 145%2C z-score: 193.6%2C E(): 0.0026%2C 28.9%25 identity in 128 aa overlap and SW:P42195 (PECS_ERWCH) regulatory protein PecS from Erwinia chrysanthemi (166 aa) fasta scores%3B opt: 109%2C z-score: 148.4%2C E(): 0.86%2C 25.6%25 identity in 129 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family. gene gene2332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2331 SCO2332 SCO2332 SCC53.23 SCC53.23 2501757 2502536 + hydrolase SCC53.23%2C possible hydrolase%2C len: 259 aa%3B similar to many e.g. SW:Q59695 (ACOC_PSEPU) acetoin dehydrogenase E2 component from Pseudomonas putida (370 aa) fasta scores%3B opt: 213%2C z-score: 235.6%2C E(): 1.2e-05%2C 30.5%25 identity in 249 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. Also contains possible stem loop structure in %25' half of CDS. gene gene2333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2332 SCO2333 SCO2333 SCC53.24 SCC53.24 2502545 2502709 + hypothetical protein SCC53.24%2C conserved hypothetical protein%2C species-specific%2C len: 54aa%3B similar to others of similar size from Streptomyces coelicolor eg. TR:CAB82047 (EMBL:AL161803) conserved hypothetical protein (63 aa) fasta scores%3B opt: 100%2C z-score: 160.0%2C E(): 0.19%2C 48.6%25 identity in 37 aa overlap. gene gene2334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2333 SCO2334 SCO2334 SCC53.25 SCC53.25 2502808 2504463 + hypothetical protein SCC53.25%2C possible integral membrane protein%2C len: 551aa%3B contains possible membrane-spanning hydrophobic regions. Similar to TR:CAB88445 (EMBL:AL353815) integral membrane protein from Streptomyces coelicolor (625 aa) fasta scores%3B opt: 1266%2C z-score: 1408.1%2C E(): 0%2C 42.4%25 identity in 502 aa overlap and TR:Q9RZ17 (EMBL:AE001862) proposed amino acid abc transporter%2C permease from Deinococcus radiodurans (484 aa) fasta scores%3B opt: 138%2C z-score: 156.1%2C E(): 0.32%2C 29.6%25 identity in 321 aa overlap. gene gene2335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2334 SCO2335 SCO2335 SCC53.26c SCC53.26c 2504417 2506702 - hypothetical protein SCC53.26c%2C possible integral membrane protein%2C len: 761 aa%3B contains possible membrane-spanning hydrophobic regions. Regions similar to many eg. TR:CAB90881 (EMBL:AL355752) integral membrane protein from Streptomyces coelicolor (287 aa) fasta scores%3B opt: 627%2C z-score: 671.4%2C E(): 6.3e-30%2C 41.0%25 identity in 290 aa overlap gene gene2336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2335 SCO2336 SCO2336 SCC53.27 SCC53.27 2506906 2508294 + integral membrane transport protein SCC53.27%2C possible integral membrane transport protein%2C len: 498aa%3B similar to many eg. SW:Q47421 (OUSA_ERWCH) osmoprotectant uptake protein from Erwinia chrysanthemi (498 aa) fasta scores%3B opt: 1554%2C z-score: 1636.5%2C E(): 0%2C 50.3%25 identity in 445 aa overlap and TR:CAB76296 (EMBL:AL158057) membrane transport protein from Streptomyces coelicolor (521 aa) fasta scores%3B opt: 1703%2C z-score: 1792.6%2C E(): 0%2C 57.2%25 identity in 437 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and Prosite match to PS00217 Sugar transport proteins signature 2. gene gene2337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2336 SCO2337 SCO2337 SCC53.28 SCC53.28 2508324 2508884 + acetyltransferase SCC53.28%2C possible acetyltransferase%2C len: 186 aa%3B regions similar to many of undefined function e.g. TR:CAB76276 (EMBL:AL158057) acetyltransferase from Streptomyces coelicolor (264 aa) fasta scores%3B opt: 131%2C z-score: 161.0%2C E(): 0.17%2C 37.5%25 identity in 112 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene2338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2337 SCO2338 SCO2338 SCC53.29 SCC53.29 2508881 2509552 + O-methyltransferase SCC53.29%2C possible O-methyltransferase%2C len: 223 aa%3B similar to many e.g. SW:Q00719 (MDMC_STRMY) macrolide O-methyltransferase (EC 2.1.1.-) from Streptomyces mycarofaciens (221 aa) fasta scores%3B opt: 405%2C z-score: 484.6%2C E(): 1.6e-19%2C 41.1%25 identity in 190 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3%2C O-methyltransferase. gene gene2339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2338 SCO2339 SCO2339 SCC53.30c SCC53.30c 2509609 2510091 - hypothetical protein SCC53.30c%2C unknown%2C len: 160aa gene gene2340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2339 SCO2340 SCO2340 SCC53.31 SCC53.31 2510090 2510497 + hypothetical protein SCC53.31%2C hypothetical protein%2C len: 135 aa%3B similar to SW:P36677 (YHDN_ECOLI) hypothetical protein from Escherichia coli (122 aa) fasta scores%3B opt: 133%2C z-score: 164.8%2C E(): 0.1%2C 33.0%25 identity in 97 aa overlap. gene gene2341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2340 SCO2341 SCO2341 SCC53.32c SCC53.32c 2510508 2511071 - hypothetical protein SCC53.32c%2C unknown%2C len: 204aa%3B contains Pro/Arg/Thr-rich region residues 10-80. gene gene2342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2341 SCO2342 SCO2342 SCC53.33c SCC53.33c 2511076 2511747 - hypothetical protein SCC53.33c%2C possible hypothetical protein%2C len: 223aa%3B contains a possible non-cleavable N-terminal signal sequence. gene gene2343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2342 SCO2343 SCO2343 SCC8A.01 SCC8A.01 2511913 2512446 + acetyltransferase SCC8A.01%2C possible acetyltransferase%2C len: 177 aa%3B similar to many of undefined function e.g. TR:CAB59671 (EMBL:AL132674) acetyltransferase from Streptomyces coelicolor (161 aa) fasta scores%3B opt: 194%2C z-score: 245.6%2C E(): 3.2e-06%2C 33.3%25 identity in 165 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family%2C score 44.30%2C E-value 2.7e-09. gene gene2344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2343 SCO2344 SCO2344 SCC8A.02c SCC8A.02c 2512483 2514552 - integral membrane transport protein SCC8A.02c%2C possible integral membrane transport protein%2C len: 689aa%3B similar to many eg. TR:CAB89031 (EMBL:AL353870) membrane transport protein from Streptomyces coelicolor (714 aa) fasta scores%3B opt: 1767%2C z-score: 1907.0%2C E(): 0%2C 46.1%25 identity in 670 aa overlap and TR:P96712 (EMBL:D50098) multidrug transporter from Bacillus subtilis (512 aa) fasta scores%3B opt: 1168%2C z-score: 1262.8%2C E(): 0%2C 37.6%25 identity in 495 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and possible membrane-spanning hydrophobic regions. gene gene2345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2344 SCO2345 SCO2345 SCC8A.03 SCC8A.03 2514601 2515959 + peptidodoglycan-binding membrane protein SCC8A.03%2C possible peptidodoglycan-binding membrane protein%2C len: 452 aa%3B contains Pfam match to entry PF01471 PG_binding_1%2C peptidoglycan binding domain%2C score 35.30%2C E-value 1.4e-06 and possible membrane-spanning hydrophobic region. gene gene2346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2345 SCO2346 SCO2346 SCC8A.04c SCC8A.04c 2515998 2516663 - hydrolase SCC8A.04c%2C possible hydrolase%2C len: 221 aa%3B similar to many e.g. TR:P96428 (EMBL:Z79692) ORF24 from Sinorhizobium meliloti (233 aa) fasta scores%3B opt: 526%2C z-score: 576.9%2C E(): 1.1e-24%2C TR:AAF18566 (EMBL:AF043232) glycerol-3-phosphate phosphatase from Emericella nidulans (Aspergillus nidulans) (236 aa) fasta scores%3B opt: 352%2C z-score: 390.2%2C E(): 2.9e-14%2C 31.8%25 identity in 233 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase and Prosite match to PS01228 Hypothetical cof family signature 1. gene gene2347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2346 SCO2347 SCO2347 SCC8A.05c SCC8A.05c 2516812 2517393 - hypothetical protein SCC8A.05c%2C possible integral membrane protein%2C len: aa%3B similar to others of undefined function eg. TR:P96229 (EMBL:Z83864) hypothetical 32.0 kD protein from Mycobacterium tuberculosis (302 aa) fasta scores%3B opt: 245%2C z-score: 295.9%2C E(): 5.1e-09%2C 32.8%25 identity in 195 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match to entry PF01169 UPF0016%2C Uncharacterized protein family UPF0016. gene gene2348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2347 SCO2348 SCO2348 SCC8A.06 SCC8A.06 2517893 2518537 + hypothetical protein SCC8A.06%2C hypothetical protein%2C len: 214 aa%3B similar to TR:P95123 (EMBL:Z83018) hypothetical protein from Mycobacterium tuberculosis (237 aa) fasta scores%3B opt: 335%2C z-score: 412.6%2C E(): 1.6e-15%2C 35.4%25 identity in 223 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2348 SCO2349 SCO2349 SCC8A.07 SCC8A.07 2518626 2520308 + hypothetical protein SCC8A.07%2C unknown%2C len: 560 aa%3B similar to TR:O52813 (EMBL:AJ223998) hypothetical protein from Amycolatopsis orientalis (508 aa) fasta scores%3B opt: 1020%2C z-score: 1115.5%2C E(): 0%2C 48.0%25 identity in 542 aa overlap. gene gene2350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2349 SCO2350 SCO2350 SCC8A.08 SCC8A.08 2520564 2521025 + hypothetical protein SCC8A.08%2C possible integral membrane protein%2C len: 153 aa%3B similar to TR:O86323 (EMBL:Z83866) hypothetical protein from Mycobacterium tuberculosis (141 aa) fasta scores%3B opt: 391%2C z-score: 477.0%2C E(): 4.2e-19%2C 48.5%25 identity in 130 aa overlap%2C to TR:CAB85407 (EMBL:AL162758) conserved inner membrane hypothetical protein from Neisseria meningitidis (132 aa) fasta scores%3B opt: 328%2C z-score: 402.9%2C E(): 5.7e-15%2C 41.9%25 identity in 129 aa overlap and to TR:Q9K461 (EMBL:AL359215) Streptomyces coelicolor integral membrane protein SC2H12.23c%2C 151 aa%3B fasta scores: opt: 533 Z-score: 626.7 E(): 2.8e-27%3B 58.741%25 identity in 143 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene2351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2350 SCO2351 SCO2351 SCC8A.09 SCC8A.09 2521200 2521838 + hypothetical protein SCC8A.09%2C possible integral membrane protein%2C len: 212aa%3B similar to many DedA-family members eg. TR:O86706 (EMBL:AL031515) integral membrane protein from Streptomyces coelicolor (208 aa) fasta scores%3B opt: 216%2C z-score: 247.9%2C E(): 2.4e-06%2C 31.4%25 identity in 191 aa overlap and SW:P09548 (DEDA_ECOLI) DedA protein from Escherichia coli (219 aa) fasta scores%3B opt: 155%2C z-score: 181.4%2C E(): 0.012%2C 26.9%25 identity in 167 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene2352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2351 SCO2352 SCO2352 SCC8A.10c SCC8A.10c 2521928 2522161 - hypothetical protein SCC8A.10c%2C unknown%2C len: 77aa gene gene2353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2352 SCO2353 SCO2353 SCC8A.11c SCC8A.11c 2522166 2522807 - hypothetical protein SCC8A.11c%2C unknown%2C len: 213aa%3B weakly similar to others eg. TR:Q9XAQ0 (EMBL:AL078618) acetyltransferase from Streptomyces coelicolor (187 aa) fasta scores%3B opt: 133%2C z-score: 173.2%2C E(): 0.035%2C 27.2%25 identity in 162 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene2354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2353 SCO2354 SCO2354 SCC8A.12 SCC8A.12 2522814 2523149 + hypothetical protein SCC8A.12%2C unknown%2C len: 111aa gene gene2355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2354 SCO2355 SCO2355 SCC8A.13 SCC8A.13 2523500 2524270 + lipoprotein SCC8A.13%2C possible lipoprotein%2C len: 256aa%3B contains an appropriately positioned Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene2357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2355 SCO2356 SCO2356 SCC8A.14 SCC8A.14 2524342 2525745 + hypothetical protein SCC8A.14%2C possible membrane protein%2C len: 467aa%3B contains a possible membrane-spanning hydrophobic region close to the N-terminus. gene gene2358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2356 SCO2357 SCO2357 SCC8A.15 SCC8A.15 2525802 2526020 + hypothetical protein SCC8A.15%2C unknown%2C doubtful CDS%2C len: 72aa gene gene2359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2357 SCO2358 SCO2358 SCC8A.16c SCC8A.16c 2526064 2526702 - two-component system response regulator SCC8A.16c%2C possible two-component system response regulator%2C len: 212aa%3B similar to many proposed regulators eg. TR:CAB81859 (EMBL:AL161691) two-component system response regulator from Streptomyces coelicolor (210 aa) fasta scores%3B opt: 736%2C z-score: 875.7%2C E(): 0%2C 61.0%25 identity in 210 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and helix-turn-helix motif 164-185aa. gene gene2360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2358 SCO2359 SCO2359 SCC8A.17c SCC8A.17c 2526699 2527817 - two-component system sensor kinase SCC8A.17c%2C possible two-component sensor kinase%2C len: 372aa%3B similar to many from Streptomyces coelicolor eg. TR:CAB81858 (EMBL:AL161691) two-component system sensor kinase (431 aa) fasta scores%3B opt: 690%2C z-score: 750.8%2C E(): 0%2C 39.3%25 identity in 399 aa overlap and SW:P27668 (UHPB_SALTY) sensor protein UhpB from Salmonella typhimurium (500 aa) fasta scores%3B opt: 269%2C z-score: 295.6%2C E(): 5.3e-09%2C 25.5%25 identity in 377 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2359 SCO2360 SCO2360 SCC8A.18 SCC8A.18 2527923 2528804 + hypothetical protein SC8A.18%2C membrane protein%2C len: 293 aa%3B region similar to many of undefined function eg. SW:Q48630 (APL_LACLA) alkaline phosphatase like protein from Lactococcus lactis (242 aa) fasta scores%3B opt: 554%2C z-score: 549.3%2C E(): 3.9e-23%2C 46.4%25 identity in 194 aa overlap. Contains Pfam match to entry PF00597 DedA%2C DedA family. Contains possible hydrophobic membrane spanning regions gene gene2362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2360 SCO2361 SCO2361 SCC8A.19c SCC8A.19c 2528722 2529534 - hypothetical protein SCC8A.19c%2C unknown%2C len: 270aa gene gene2363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2361 SCO2362 SCO2362 SCC8A.20c SCC8A.20c 2529534 2532053 - hypothetical protein SCC8A.20c%2C unknown%2C len: 839 aa%3B regions similar to others of undefined function e.g. TR:AAF11767 (EMBL:AE002054) hypothetical protein from Deinococcus radiodurans (353 aa) fasta scores%3B opt: 463%2C z-score: 489.2%2C E(): 8.7e-20%2C 40.3%25 identity in 355 aa overlap gene gene2364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2362 SCO2363 SCO2363 SCC8A.21c SCC8A.21c 2532132 2533298 - ATP/GTP-binding protein SCC8A.21c%2C possible ATP/GTP-binding protein%2C len: 388aa%3B similar to TR:AAF11768 (EMBL:AE002054) hypothetical protein from Deinococcus radiodurans (310 aa) fasta scores%3B opt: 146%2C z-score: 175.2%2C E(): 0.027%2C 32.0%25 identity in 347 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene2365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2363 SCO2364 SCO2364 SCC8A.22 SCC8A.22 2533506 2534501 + hypothetical protein SCC8A.22%2C unknown%2C len: 331 aa%3B regions similar to many of undefined function eg. TR:Q9ZBZ1 (EMBL:AL034355) hypothetical protein from Streptomyces coelicolor (482 aa) fasta scores%3B opt: 686%2C z-score: 521.2%2C E(): 1.4e-21%2C 51.0%25 identity in 247 aa overlap and SW:P18782 (TERE_ALCSP) tellurium resistance protein from plasmid IncHI2 pMER610 of Alcaligenes sp. (191 aa) fasta scores%3B opt: 339%2C z-score: 271.3%2C E(): 1.2e-07%2C 35.9%25 identity in 195 aa overlap gene gene2366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2364 SCO2365 SCO2365 SCC8A.23c SCC8A.23c 2534532 2535269 - hypothetical protein SCC8A.23c%2C unknown%2C len: 245 aa%3B similar to proteins associated with resistance to tellurium salts eg. TR:Q44313 (EMBL:M20238) tellurium salts resistance protein from plasmid pMER610 of Alcaligenes sp. (339 aa) fasta scores%3B opt: 408%2C z-score: 510.3%2C E(): 5.8e-21%2C 38.4%25 identity in 219 aa overlap gene gene2367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2365 SCO2366 SCO2366 SCC8A.24c SCC8A.24c 2535421 2536563 - hypothetical protein SCC8A.24c%2C possible integral membrane protein%2C len: 380aa%3B similar to other eg. TR:Q9Z654 (EMBL:AF102543) hypothetical protein from Zymomonas mobilis (339 aa) fasta scores%3B opt: 428%2C z-score: 504.2%2C E(): 1.3e-20%2C 43.3%25 identity in 374 aa overlap and TR:CAB57414 (EMBL:AL121746) integral membrane protein from Streptomyces coelicolor (370 aa) fasta scores%3B opt: 2038%2C z-score: 2376.3%2C E(): 0%2C 85.6%25 identity in 369 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene2368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2366 SCO2367 SCO2367 SCC8A.25c SCC8A.25c 2536613 2537188 - hypothetical protein SCC8A.25c%2C conserved hypothetical protein%2C len: 191aa%3B similar to proteins associated with resistance to tellurium salts e.g. SW:Q52357 (TERD_SERMA) tellurium resistance protein TerD from Serratia marcescens (192 aa) fasta scores%3B opt: 853%2C z-score: 1006.2%2C E(): 0%2C 67.2%25 identity in 192 aa overlap. Also strongly similar to others from Streptomyces coelicolor e.g. TR:CAB62770 (EMBL:AL356892) and neighbouring CDS SCC8A.26c. gene gene2369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2367 SCO2368 SCO2368 SCC8A.26c SCC8A.26c 2537340 2537915 - hypothetical protein SCC8A.26c%2C conserved hypothetical protein%2C len: 191aa%3B similar to proteins associated with resistance to tellurium salts e.g. SW:Q52357 (TERD_SERMA) tellurium resistance protein TerD from Serratia marcescens (192 aa) fasta scores%3B opt: 866%2C z-score: 1036.9%2C E(): 0%2C 65%2C8%25 identity in 190 aa overlap. Also strongly similar to others from Streptomyces coelicolor e.g. TR:CAB62770 (EMBL:AL356892) and neighbouring CDS SCC8A.26c gene gene2370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2368 SCO2369 SCO2369 SCC8A.27c SCC8A.27c 2538097 2538555 - thiol-specific antioxidant protein SCC8A.27c%2C possible thiol-specific antioxidant protein%2C len: 152 aa%3B similar to many e.g. SW:O24364 (BAS1_SPIOL) 2-cys peroxiredoxin Bas1 precursor from Spinacia oleracea (Spinach) (265 aa) fasta scores%3B opt: 352%2C z-score: 450.7%2C E(): 1.2e-17%2C 39.9%25 identity in 158 aa overlap and SW:Q10520 (Y01J_MYCTU) hypothetical protein from Mycobacterium tuberculosis (153 aa) fasta scores%3B opt: 507%2C z-score: 648.2%2C E(): 1.2e-28%2C 48.7%25 identity in 150 aa overlap. Contains Pfam match to entry PF00578 AhpC-TSA%2C AhpC/TSA family. gene gene2371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2369 SCO2370 SCO2370 SCC8A.28c SCC8A.28c 2538717 2539196 - hypothetical protein SCC8A.28c%2C unknown%2C len: 159 aa%3B similar to others from mycobacteria e.g. SW:Q10521 (YM39_MYCTU) hypothetical protein from Mycobacterium tuberculosis (158 aa) fasta scores%3B opt: 447%2C z-score: 518.6%2C E(): 2e-21%2C 50.4%25 identity in 141 aa overlap gene gene2372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2370 SCO2371 SCO2371 aceE aceE 2539576 2542332 + pyruvate dehydrogenase subunit E1 E1 component%3B part of pyruvate dehydrogenase%3B forms a complex with DlaT and LpdC gene gene2373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2371 SCO2372 SCO2372 SCC8A.30c SCC8A.30c 2542460 2542768 - small hydrophobic protein SCC8A.30c%2C possible small hydrophobic protein%2C len: 102 aa%3B similar to TR:O86580 (EMBL:AL031184) small hydrophobic protein from Streptomyces coelicolor (97 aa) fasta scores%3B opt: 119%2C z-score: 161.8%2C E(): 0.15%2C 33.3%25 identity in 81 aa overlap. Contains possible membrane-spanning hydrophobic region. gene gene2374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2372 SCO2373 SCO2373 SC4A7.01c SC4A7.01c 2543007 2544617 - tetracenomycin C efflux protein SCC8A.31c%2C tcmA%2C tetracenomycin C efflux protein%2C partial CDS%2C len: >331aa%3B similar to many export protein especially SW:TCMA_STRGA( EMBL:M80674) tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa) fasta scores%3B opt: 1285%2C z-score: 1299.8%2C E(): 0%2C 59.8%25 identity in 323 aa overlap.~SC1E12.01c%2C tcmA%2C tetracenomycin C efflux protein%2C partial CDS%2C len: >103 aa. Highly similar over the available sequence to Streptomyces glaucescens SW:TCMA_STRGA(EMBL:M80674) tetracenomycin C resistance and export protein (538 aa)%2C fasta scores opt: 500 z-score: 635.7 E(): 5e-28 70.9%25 identity in 103 aa overlap. Also similar to several from Streptomyces coelicolor: SW:AC22_STRCO(EMBL:M64683) probable actinorhodin transporter ACTII-2 (578 aa)%2C fasta scores opt: 246 z-score: 316.7 E(): 2.9e-10 35.8%25 identity in 109 aa overlap and SCF37.21c (EMBL:AL133210) probable export protein (533 aa)%2C fasta scores opt: 378 z-score: 434.6 E(): 8e-19 47.6%25 identity in 103 aa overlap. Contains possible membrane spanning hydrophobic domains.~SC4A7.01c%2C tcmA%2C tetracenomycin C resistance and export protein (partial CDS)%2C len: >173 aa%3B highly similar to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA%2C 538 aa%3B fasta scores: opt: 813 z-score: 922.3 E(): 0%3B 78.6%25 identity in 159 aa overlap%2C to SW:AC22_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhidin transporter ActII-2%2C 578 aa%3B fasta scores: opt: 396 z-score: 452.6 E(): 7.9e-18%3B 37.8%25 identity in 164 aa overlap and to S. coelicolor SCF37.21c%2C 533 aa%3B fasta scores: opt: 641 z-score: 623.5 E(): 2.4e-29%3B 56.7%25 identity in 171 aa overlap gene gene2375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2373 SCO2374 SCO2374 SC4A7.02 SC4A7.02 2544733 2545416 + transcriptional regulator SC4A7.02%2C probable transcriptional regulator%2C len: 227 aa%3B similar to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR%2C 226 aa%3B fasta scores: opt: 594 z-score: 727.4 E(): 0%3B 46.5%25 identity in 215 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 49..70 (+3.84 SD) gene gene2376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2374 SCO2375 SCO2375 SC4A7.03 SC4A7.03 2545471 2546691 + hypothetical protein SC4A7.03%2C possible hypothetical protein%2C len: 406 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9X8R0 (EMBL:AL049754) Streptomyces coelicolor hypothetical 33.9 kD protein%2C SCH10.21c%2C 329 aa%3B fasta scores: opt: 634 z-score: 714.7 E(): 2e-32%3B 39.3%25 identity in 346 aa overlap. Contains possible N-terminal signal peptide sequence gene gene2377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2375 SCO2376 SCO2376 SC4A7.04 SC4A7.04 2546758 2547645 + hypothetical protein SC4A7.04%2C hypothetical protein%2C len: 295 aa%3B similar to TR:Q9L067 (EMBL:AL163641) Streptomyces coelicolor hypothetical protein SCC105.18%2C 298 aa%3B fasta scores: opt: 556 Z-score: 591.0 E(): 2.8e-25%3B 37.415%25 identity in 294 aa overlap gene gene2378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2376 SCO2377 SCO2377 SC4A7.05c SC4A7.05c 2547771 2548787 - aldo/keto reductase SC4A7.05c%2C probable aldo/keto reductase%2C len: 338 aa%3B similar to TR:Q9X5G7 (EMBL:AF124928) Streptomyces clavuligerus aldo/keto reductase family 2 enzyme Cvm1%2C 344 aa%3B fasta scores: opt: 916 z-score: 1035.7 E(): 0%3B 47.7%25 identity in 331 aa overlap gene gene2379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2377 SCO2378 SCO2378 SC4A7.06c SC4A7.06c 2548784 2549374 - MerR family transcriptional regulator SC4A7.06c%2C possible merR-family transciptional regulator%2C len: 196 aa%3B similar to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA%2C 253 aa%3B fasta scores: opt: 187 z-score: 225.2 E(): 3.7e-05%3B 32.7%25 identity in 110 aa overlap. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and a possible helix-turn-helix motif at residues 72..93 (+3.19 SD) gene gene2380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2378 SCO2379 SCO2379 SC4A7.07 SC4A7.07 2549404 2549871 + acetyltransferase SC4A7.07%2C possible acetyltransferase%2C len: 155 aa%3B similar to TR:Q55840 (EMBL:D64004) Synechocystis sp hypothetical 23.4 kD protein%2C 204 aa%3B fasta scores: opt: 134 z-score: 171.7 E(): 0.035%3B 26.6%25 identity in 124 aa overlap and to SW:RIMI_ECOLI (EMBL:X06117) Escherichia coli ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128) RimI%2C 148 aa%3B fasta scores: opt: 115 z-score: 151.3 E(): 0.48%3B 34.5%25 identity in 55 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene2381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2379 SCO2380 SCO2380 SC4A7.08 SC4A7.08 2549891 2550712 + hypothetical protein SC4A7.08%2C hypothetical protein%2C len: 273 aa%3B similar to TR:O53531 (EMBL:AL021925) Mycobacterium tuberculosis hypothetical 28.a kD protein MTV022.07c%2C 272 aa%3B fasta scores: opt: 1011 z-score: 1132.5 E(): 0%3B 56.8%25 identity in 271 aa overlap gene gene2382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2380 SCO2381 SCO2381 SC4A7.09 SC4A7.09 2550901 2551737 + hypothetical protein SC4A7.09%2C hypothetical protein%2C len: 278 aa%3B simialr to various hypothetical proteins%2C e.g. TR:Q9X8M2 (EMBL:AL049628) Streptomyces coelicolor hypothetical 31.5 kD protein SCE94.16c%2C 280 aa%3B fasta scores: opt: 1333 z-score: 1595.1 E(): 0%3B 76.4%25 identity in 271 aa overlap gene gene2383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2381 SCO2382 SCO2382 SC4A7.10 SC4A7.10 2551706 2551903 + hypothetical protein SC4A7.10%2C hypothetical protein%2C len: 65 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9Z544 (EMBL:AL035212) Streptomyces coelicolor hypothetical 8.2 kD protein%2C 77 aa%3B fasta scores: opt: 186 z-score: 270.2 E(): 1.1e-07%3B 60.0%25 identity in 55 aa overlap%2C to S. coelicolor SC2H4.17c%2C 81 aa%3B fasta scores: opt: 165 z-score: 212.0 E(): 2e-06%3B 50.0%25 identity in 60 aa overlap and to S. coelicolor SC4G2.04%2C 67 aa%3B fasta scores: opt: 149 z-score: 195.0 E(): 1.8e-05%3B 51.0%25 identity in 51 aa overlap gene gene2384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2382 SCO2383 SCO2383 SC4A7.11 SC4A7.11 2552256 2556893 + hypothetical protein SC4A7.11%2C possible hypothetical protein%2C len: 1545 aa%3B similar in its central part to SW:STFR_ECOLI (EMBL:AE000234) Escherichia coli side tail fiber protein homolog from labmboid prophage RAC StfR or B1372%2C 1120 aa%3B fasta scores: opt: 494 Z-score: 414.4 E(): 1.9e-15%3B 31.461%25 identity in 445 aa overlap. Contains high percentage of aa residues A and G. Contains Pfam match to entry PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain and possible N-terminal region signal peptide sequence. Also contains possible colied-coil regions at approx. residues 655..761%2C 789..846 and 1098..1163 gene gene2385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2383 SCO2384 SCO2384 SC4A7.12 SC4A7.12 2556886 2557305 + hypothetical protein SC4A7.12%2C unknown%2C len: 139 aa gene gene2386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2384 SCO2385 SCO2385 SC4A7.13c SC4A7.13c 2557326 2557982 - hypothetical protein SC4A7.13c%2C hypothetical protein%2C len: 218 aa%3B similar to various hypothetical proteins%2C e.g. TR:Y181_MYCTU (EMBL:Z97050) Mycobacterium tuberculosis hypothetical 26.3 kD protein MCTI28.21c%2C 244 aa%3B fasta scores: opt: 410 z-score: 496.1 E(): 3e-20%3B 39.0%25 identity in 236 aa overlap gene gene2387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2385 SCO2386 SCO2386 SC4A7.14 SC4A7.14 2558045 2559250 + hypothetical protein SC4A7.14%2C hypothetical protein%2C len: 401 aa%3B similar to various hypothetical proteins%2C e.g. SW:YM42_MYCTU (EMBL:Z70692) Mycobacterium tuberculosis hypothetical 44.6 kD protein RV2242%2C 414 aa%3B fasta scores: opt: 581 z-score: 650.9 E(): 7.2e-29%3B 43.0%25 identity in 409 aa overlap gene gene2388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2386 SCO2387 SCO2387 fabD fabD 2559340 2560290 + ACP S-malonyltransferase gene gene2389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2387 SCO2388 SCO2388 fabH fabH 2560307 2561338 + 3-oxoacyl-ACP synthase III FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs%3B in Pseudomonas this protein is involved in quinolone signal biosynthesis gene gene2390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2388 SCO2389 SCO2389 acpP acpP 2561443 2561691 + acyl carrier protein carries the fatty acid chain in fatty acid biosynthesis gene gene2391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2389 SCO2390 SCO2390 fabF fabF 2561801 2563090 + 3-oxoacyl-ACP synthase gene gene2392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2390 SCO2391 SCO2391 SC4A7.19c SC4A7.19c 2563192 2563686 - hypothetical protein SC4A7.19c%2C hypothetical protein%2C len: 164 aa%3B identical to previously sequenced TR:Q54209 (EMBL:L43074) Streptomyces glaucescens ORF5%2C 164 aa and similar to TR:O53530 (EMBL:AL021925) Mycobacterium tuberculosis hypothetical 18.9 kD protein%2C 177 aa%3B fasta scores: opt: 489 z-score: 628.5 E(): 1.3e-27%3B 42.6%25 identity in 162 aa overlap gene gene2393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2391 SCO2392 SCO2392 SC4A7.20 SC4A7.20 2563944 2564861 + lipoprotein SC4A7.20%2C possible lipoprotein%2C len: 305 aa%3B similar to TR:Q9X7W9 (EMBL:AL049485) Streptomyces coelicolor hypothetical 28.1 kD protein%2C 261 aa%3B fasta scores: opt: 137 z-score: 160.4 E(): 0.15%3B 31.0%25 identity in 187 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene2394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2392 SCO2393 SCO2393 SC4A7.21 SC4A7.21 2564900 2565871 + aldose 1-epimerase SC4A7.21%2C probable aldose 1-epimerase%2C len: 323 aa%3B similar to TR:Q9WYB8 (EMBL:AE001710) Thermotoga maritima aldose 1-epimerase TM0282%2C 356 aa%3B fasta scores: opt: 677 z-score: 752.5 E(): 0%3B 47.5%25 identity in 345 aa overlap%2C to SW:GALM_ECOLI (EMBL:U13636) Escherichia coli aldose 1-epimerase (EC 5.1.3.3) (mutarotase) GalM%2C 346 aa%3B fasta scores: opt: 543 z-score: 605.1 E(): 2.5e-26%3B 39.0%25 identity in 346 aa overlap and to S. coelicolor SC4A7.35%2C 366 aa%3B fasta scores: opt: 838 z-score: 839.4 E(): 0%3B 54.2%25 identity in 347 aa overlap. Contains Pfam match to entry PF01263 Aldose_epim%2C Aldose 1-epimerase and match to PRosite entry PS00545 Aldose 1-epimerase active site gene gene2395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2393 SCO2394 SCO2394 SC4A7.22 SC4A7.22 2566207 2567460 + hypothetical protein SC4A7.22%2C hypothetical protein%2C len: 417 aa%3B similar to TR:Q9I783 (EMBL:AE004444) Pseudomonas aeruginosa hypothetical protein PA0049%2C 553 aa%3B fasta scores: opt: 566 Z-score: 609.9 E(): 2.4e-26%3B 35.800%25 identity in 500 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2394 SCO2395 SCO2395 SC4A7.23c SC4A7.23c 2567432 2568256 - hypothetical protein SC4A7.23c%2C possible integral membrane protein%2C len: 274 aa%3B low similarities to SW:CYSZ_ECOLI (EMBL:AE000329) Escheichia coli CysZ protein%2C 253 aa%3B fasta scores: opt: 258 z-score: 295.2 E(): 4.6e-09%3B 25.8%25 identity in 244 aa overlap gene gene2397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2395 SCO2396 SCO2396 SC4A7.24c SC4A7.24c 2568352 2568771 - hypothetical protein SC4A7.24c%2C hypothetical protein%2C len: 139 aa%3B similar to TR:O68390 (EMBL:AF036166) Xanthomonas campestris organic hydroperoxide resistance protein Ohr%2C 142 aa%3B fasta scores: opt: 478 z-score: 578.1 E(): 8e-25%3B 55.2%25 identity in 134 aa overlap and to TR:P70736 (EMBL:Y09102) Acinetobacter sp. hypothetical 15.2 kD protein%2C 143 aa%3B fasta scores: opt: 442 z-score: 535.7 E(): 1.9e-22%3B 53.3%25 identity in 137 aa overlap gene gene2398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2396 SCO2397 SCO2397 SC4A7.25c SC4A7.25c 2568888 2569982 - oxidoreductase SC4A7.25c%2C probable oxidoreductase%2C len: 364 aa%3B similar to SW:YNCB_ECOLI (EMBL:AE000242) Escherichia coli NADP-dependent oxidoreductase in TehB-RhsE intergenic region YncB%2C 353 aa%3B fasta scores: opt: 950 z-score: 1018.4 E(): 0%3B 43.6%25 identity in 335 aa overlap and to SW:P2_ARATH (EMBL:Z49268) Arabidopsis thaliana probable NADP-dependent oxidoreductase P2%2C 342 aa%3B fasta scores: opt: 880 z-score: 944.2 E(): 0%3B 45.4%25 identity in 328 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene2399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2397 SCO2398 SCO2398 SC4A7.26 SC4A7.26 2570030 2570485 + MarR family transcriptonal regulator SC4A7.26%2C possible marR-family transcriptonal regulator%2C len: 151 aa%3B similar to TR:Q9WZS3 (EMBL:AE001749) Thermotoga maritima transcriptional regulator%2C %2C marR family TM0816%2C 142 aa%3B fasta scores: opt: 167 z-score: 210.9 E(): 0.00023%3B 31.7%25 identity in 139 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene2400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2398 SCO2399 SCO2399 SC4A7.27 SC4A7.27 2570546 2571427 + hypothetical protein SC4A7.27%2C hypothetical protein%2C len: 293 aa%3B low similarity to TR:Q9XAH5 (EMBL:AL096825) Streptomyces coelicolor hypothetical 60.3 kD protein SC6G3.05%2C 588 aa%3B fasta scores: opt: 128 z-score: 149.7 E(): 0.59%3B 28.8%25 identity in 313 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene2401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2399 SCO2400 SCO2400 SC4A7.28c SC4A7.28c 2571440 2572189 - hypothetical protein SC4A7.28c%2C membrane protein%2C len: 249 aa. Contains 1 possible hydrophobic membrane spanning region gene gene2402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2400 SCO2401 SCO2401 SC4A7.29 SC4A7.29 2572404 2573570 + dehydratase SC4A7.29%2C possible dehydratase%2C len: 388 aa%3B similar to C-terminal region of SW:DGOA_ECOLI (EMBL:L10328) Escherichia coli galactonate dehydratase (EC 4.2.1.6) GdoA%2C 587 aa%3B fasta scores: opt: 751 z-score: 864.7 E(): 0%3B 35.0%25 identity in 383 aa overlap. Contains Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family gene gene2403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2401 SCO2402 SCO2402 SC4A7.30 SC4A7.30 2573567 2574583 + dehydrogenase SC4A7.30%2C possible dehydrogenase%2C len: 338 aa%3B similar to SW:TDH_ECOLI (EMBL:X06690) Escherichia coli threonine 3-dehydrogenase (EC 1.1.1.103) Tdh%2C 341 aa%3B fasta scores: opt: 468 z-score: 507.9 E(): 6.6e-21%3B 28.4%25 identity in 328 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and match to Prosite entry PS00059 Zinc-containing alcohol dehydrogenases signature gene gene2404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2402 SCO2403 SCO2403 SC4A7.31 SC4A7.31 2574719 2575690 + hypothetical protein SC4A7.31%2C hypothetical protein%2C len: 323 aa%3B similar to TR:O27045 (EMBL:AE000870) Methanobacterium thermoautotrophicum hypothetical 32.8 kD protein MTH964%2C 299 aa%3B fasta scores: opt: 685 z-score: 763.8 E(): 0%3B 40.3%25 identity in 300 aa overlap gene gene2405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2403 SCO2404 SCO2404 SC4A7.32 SC4A7.32 2575786 2576895 + sugar-binding receptor SC4A7.32%2C probable sugar-binding receptor%2C len: 369 aa%3B similar to SW:CVE2_AGRTU (EMBL:X97456) Agrobacterium tumefaciens multiple sugar-binding periplasmic receptor chve precursor%2C ChvE%2C 354 aa%3B fasta scores: opt: 1391 z-score: 1497.2 E(): 0%3B 60.3%25 identity in 350 aa overlap. Contains possible signal peptide sequence%2C Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and Prosite match correctly situated PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene2406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2404 SCO2405 SCO2405 SC4A7.33 SC4A7.33 2576928 2578505 + sugar-transport ATP binding protein SC4A7.24%2C probable sugar-transport ATP binding protein%2C len: 513 aa%3B similar to TR:AAD45713 (EMBL:AF160811) Bacillus stearothermophilus L-arabinose transport%2C ATP binding protein AraG%2C 513 aa%3B fasta scores: opt: 2220 z-score: 2417.4 E(): 0%3B 65.5%25 identity in 510 aa overlap and to SW:ALSA_ECOLI (EMBL:U14003) Escherichia coli D-allose transport ATP-binding protein AlsA%2C 510 aa%3B fasta scores: opt: 1200 z-score: 1308.3 E(): 0%3B 40.7%25 identity in 514 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and two matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene2407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2405 SCO2406 SCO2406 SC4A7.34 SC4A7.34 2578502 2579746 + sugar transport permease SC4A7.34%2C probable sugar transport permease%2C len: 414 aa%3B similar to TR:AAD45714 (EMBL:AF160811) Bacillus stearothermophilus L-arabinose membrane permease AraH%2C 407 aa%3B fasta scores: opt: 1448 z-score: 1515.1 E(): 0%3B 56.9%25 identity in 385 aa overlap and to SW:XYLH_HAEIN (EMBL:U32791) Haemophilus influenzae xylose transport permease XylH%2C 375 aa%3B fasta scores: opt: 970 z-score: 1017.9 E(): 0%3B 42.6%25 identity in 376 aa overlap gene gene2408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2406 SCO2407 SCO2407 SC4A7.35 SC4A7.35 2579862 2580962 + aldose 1-epimerase SC4A7.35%2C probable aldose 1-epimerase%2C len: 366 aa%3B similar to SW:GALM_ACICA (EMBL:X03893) Acinetobacter calcoaceticus aldose 1-epimerase precursor (EC 5.1.3.3) Mro%2C 381 aa%3B fasta scores: opt: 1022 z-score: 1184.4 E(): 0%3B 44.3%25 identity in 350 aa overlap and to S. coelicolor SC4A7.21%2C 323 aa%3B fasta scores: opt: 838 z-score: 928.5 E(): 0%3B 54.2%25 identity in 347 aa overlap. Contains Pfam match to entry PF01263 Aldose_epim%2C Aldose 1-epimerase gene gene2409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2407 SCO2408 SCO2408 SC4A7.36 SC4A7.36 2581080 2582705 + aminotransferase SC4A7.36%2C possible aminotransferase%2C len: 541 aa%3B similar to SW:HIS8_METJA (EMBL:U67539) Methanococcus jannaschii probable histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC%2C 373 aa%3B fasta scores: opt: 390 z-score: 299.5 E(): 2.6e-09%3B 25.1%25 identity in 334 aa overlap. Contains Pfam match to entry PF00222 aminotran_2%2C Aminotransferases class-II gene gene2410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2408 SCO2409 SCO2409 SC4A7.37c SC4A7.37c 2582733 2583998 - hypothetical protein SC4A7.37c%2C possible hypothetical protein%2C len: 421 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB52057 (EMBL:AL109732) Streptomyces coelicolor hypothetical 61.4 kD protein SC7H2.15c%2C 597 aa%3B fasta scores: opt: 1148 z-score: 809.3 E(): 0%3B 51.3%25 identity in 388 aa overlap. Contains proline-rich region and possible N-terminal region signal peptide sequence gene gene2411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2409 SCO2410 SCO2410 SC4A7.38c SC4A7.38c 2584078 2584839 - hypothetical protein SC4A7.38c%2C possible integral membrane protein%2C len: 253 aa%3B similar to various hypothetical proteins%2C e.g. TR:O07422 (EMBL:Z97050) Mycobacterium tuberculosis hypothetical 25.9 kD protein MTCI28.18%2C 244 aa%3B fasta scores: opt: 183 z-score: 204.4 E(): 0.00053%3B 31.0%25 identity in 171 aa overlap and to S. coelicolor SC4A7.40c%2C 219 aa%3B fasta scores: opt: 323 z-score: 280.2 E(): 3.2e-10%3B 40.5%25 identity in 200 aa overlap gene gene2412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2410 SCO2411 SCO2411 SC4A7.39c SC4A7.39c 2584886 2585440 - hypothetical protein SC4A7.39c%2C possible membrane protein%2C len: 184 aa%3B similar to various hypothetical proteins%2C e.g. SW:Y07R_MYCTU (EMBL:Z75555) Mycobacterium tuberculosis hypothetical 28.3 kD protein%2C 261 aa%3B fasta scores: opt: 188 z-score: 223.5 E(): 4.6e-05%3B 28.7%25 identity in 164 aa overlap and to S/ coelicolor SC4A7.41c%2C >165 aa%3B fasta scores: opt: 240 z-score: 255.3 E(): 7.9e-09%3B 36.0%25 identity in 161 aa overlap. Contains possible hydrophobic membrane spanning region gene gene2413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2411 SCO2412 SCO2412 SC4A7.40c SC4A7.40c 2585467 2586126 - hypothetical protein SC4A7.40c%2C possible membrane protein%2C len: 219 aa%3B similar to C-terminus of TR:P71415 (EMBL:U75438) Halobacterium salinarium transducer Htd protein%2C 777 aa%3B fasta scores: opt: 182 z-score: 198.8 E(): 0.0011%3B 30.6%25 identity in 193 aa overlap and to S. coelicolor SC4A7.38c%2C 253 aa%3B fasta scores: opt: 323 z-score: 286.8 E(): 1.4e-10%3B 40.5%25 identity in 200 aa overlap gene gene2414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2412 SCO2413 SCO2413 SC4A7.41c SC4A7.41c 2586123 2586635 - hypothetical protein SC8A2.01c%2C possible hypothetical protein (fragment)%2C len: >42 aa. Contains possible N-terminal region signal peptide sequence~SC4A7.41c%2C possible membrane protein (partial CDS)%2C len: >165 aa%3B similar to various hypothetical proteins%2C e.g. TR:P71754 (EMBL:Z81368) Mycobacterium tuberculosis hypothetical 19.9 kD protein MCTY253.31%2C 185 aa%3B fasta scores: opt: 125 z-score: 158.3 E(): 0.2%3B 26.0%25 identity in 150 aa overlap and to S. coelicolor SC4A7.39c%2C 192 aa%3B fasta scores: opt: 240 z-score: 236.5 E(): 8.8e-08%3B 36.0%25 identity in 161 aa overlap gene gene2415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2413 SCO2414 SCO2414 SC8A2.02c SC8A2.02c 2586632 2587933 - hypothetical protein SC8A2.02c%2C possible hypothetical protein%2C len: 433 aa%3B similar to TR:O53972 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 46.7 kDa protein MTV051.09%2C 437 aa%3B fasta scores: opt: 529 z-score: 488.9 E(): 1e-19%3B 31.3%25 identity in 438 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence gene gene2416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2414 SCO2415 SCO2415 SC8A2.03c SC8A2.03c 2587930 2589171 - hypothetical protein SC8A2.03c%2C possible hypothetical protein%2C len: 413 aa%3B similar to TR:O53971 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 40.2 kDa protein MTV051.08%2C 377 aa%3B fasta scores: opt: 685 z-score: 681.0 E(): 2.1e-30%3B 36.0%25 identity in 311 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence gene gene2417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2415 SCO2416 SCO2416 SC8A2.04c SC8A2.04c 2589168 2590181 - hypothetical protein SC8A2.04c%2C possible hypothetical protein%2C len: 337 aa%3B similar to TR:O53970 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 44.4 kDa protein MTV051.07%2C 423 aa%3B fasta scores: opt: 596 z-score: 625.4 E(): 2.6e-27%3B 33.1%25 identity in 320 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence gene gene2418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2416 SCO2417 SCO2417 SC8A2.05c SC8A2.05c 2590178 2591233 - hypothetical protein SC8A2.05c%2C possible hypothetical protein%2C len: 351 aa%3B similar to TR:O53969 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 43.7 kDa protein MTV051.06%2C 410 aa%3B fasta scores: opt: 683 z-score: 769.5 E(): 0%3B 33.4%25 identity in 368 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence gene gene2419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2417 SCO2418 SCO2418 SC8A2.06c SC8A2.06c 2591230 2592294 - hypothetical protein SC8A2.06c%2C possible hypothetical protein%2C len: 354 aa%3B similar to TR:O53968 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 36.5 kDa protein MTV051.05%2C 342 aa%3B fasta scores: opt: 665 z-score: 735.0 E(): 0%3B 37.6%25 identity in 343 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence gene gene2420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2418 SCO2419 SCO2419 SC8A2.07c SC8A2.07c 2592291 2593547 - hypothetical protein SC8A2.07c%2C possible hypothetical protein%2C len: 418 aa%3B similar to TR:O53967 (EMBL:AL022073) Mycobacterium tuberculosis mce-family protein MTV051.04%2C 425 aa%3B fasta scores: opt: 548 z-score: 564.7 E(): 6.2e-24%3B 33.0%25 identity in 367 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence gene gene2421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2419 SCO2420 SCO2420 SC8A2.08c SC8A2.08c 2593549 2594355 - ABC-transporter integral membrane protein SCC42.01c%2C possible ABC-transporter integral membrane protein (fragment)%2C len: >161 aa%3B similar to TR:O53545 (EMBL:AL022022) Mycobacterium tuberculosis hypothetical 29.6 kD protein MTV023.07c%2C 280 aa%3B fasta scores: opt: 565 z-score: 630.0 E(): 1.3e-27%3B 54.5%25 identity in 154 aa overlap. Contains possible hydrophobic membrane spanning regions~SC8A2.08c%2C conserved hypothetical protein (fragment)%2C len: >139 aa%3B similar to TR:O53966 (EMBL:AL022073) Mycobacterium tuberculosis hypothetical 28.1 kDa protein MTV051.03%2C 271 aa%3B fasta scores: opt: 474 z-score: 595.0 E(): 1.3e-25%3B 48.6%25 identity in 138 aa overlap gene gene2422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2420 SCO2421 SCO2421 SCC42.02c SCC42.02c 2594362 2595126 - ABC-transporter integral membrane protein SCC42.02c%2C possible ABC-transporter integral membrane protein%2C len: 254 aa%3B similar to TR:O53546 (EMBL:AL022022) Mycobacterium tuberculosis hypothetical 26.6 kD protein MTV023.08c%2C 254 aa%3B fasta scores: opt: 881 z-score: 1004.0 E(): 0%3B 50.8%25 identity in 242 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2421 SCO2422 SCO2422 SCC42.03c SCC42.03c 2595123 2596154 - ABC transporter ATP-binding protein SCC42.03c%2C possible ABC-transporter ATP-binding protein%2C len: 343 aa%3B similar to SW:YRBF_HAEIN (EMBL:U32788) Haemophilus influenzae hypothetical ABC-transporter ATP-binding protein HI1087%2C 264 aa%3B fasta scores: opt: 680 z-score: 686.6 E(): 8.9e-31%3B 41.4%25 identity in 244 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene2424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2422 SCO2423 SCO2423 SCC42.04 SCC42.04 2596787 2597419 + hypothetical protein SCC42.04%2C possible hypothetical protein%2C len: 210 aa. Contains possible N-terminal region signal peptide sequence gene gene2425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2423 SCO2424 SCO2424 SCC42.05 SCC42.05 2597556 2599157 + hypothetical protein SCC42.05%2C possible hypothetical protein%2C len: 533 aa. Contains possible N-terminal region signal peptide sequence. High content in alanine amino acid residues gene gene2426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2424 SCO2425 SCO2425 SCC42.06 SCC42.06 2599192 2600133 + hypothetical protein SCC42.06%2C possible hypothetical protein%2C len: 313 aa. Contains possible N-terminal region signal peptide sequence gene gene2427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2425 SCO2426 SCO2426 SCC42.07 SCC42.07 2600318 2601529 + regulatory protein SCC42.07%2C possible regulatory protein%2C len: 403 aa%3B similar to TR:CAB88166 (EMBL:AL352956) Streptomyces coelicolor regulatory protein SC1H10.22c%2C 555 aa%3B fasta scores: opt: 157 z-score: 183.8 E(): 0.0091%3B 26.8%25 identity in 447 aa overlap. Contains a possible helix-turn-helix motif at residues 347..863 (+3.80 SD) and two TTA leucine codons (codon 170 and codon 174)%2C possible targets for bldA regulation gene gene2428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2426 SCO2427 SCO2427 SCC42.08c SCC42.08c 2601569 2602537 - arabinase SCC42.08c%2C probable arabinase%2C len: 322 aa%3B similar to SW:ABNA_ASPNG (EMBL:L23430) Aspergillus niger arabinan endo-1%2C5-alpha-L-arabinosidase A precursor (EC 3.2.1.99) AbnA%2C 321 aa%3B fasta scores: opt: 764 z-score: 832.4 E(): 0%3B 42.0%25 identity in 326 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2427 SCO2428 SCO2428 SCC42.09 SCC42.09 2602879 2604447 + phosphate binding protein SCC42.09%2C possible phosphate binding protein ( hypothetical protein)%2C len: 522 aa%3B C-terminal domain similar to TR:Q9Z9M3 (EMBL:AB017492) Pseudomonas aeruginosa phosphate binding protein PtpS%2C 323 aa%3B fasta scores: opt: 226 z-score: 266.2 E(): 2.3e-07%3B 25.3%25 identity in 328 aa overlap. Contains Pfam match to entry PF01449 PstS%2C Phosphate-binding protein and possible N-terminal region signal peptide sequence gene gene2430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2428 SCO2429 SCO2429 SCC42.10c SCC42.10c 2604477 2605133 - hypothetical protein SCC42.10c%2C possible hypothetical protein%2C len: 218 aa. Contains possible N-terminal region signal peptide sequence gene gene2431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2429 SCO2430 SCO2430 SCC24.01 SCC24.01 2605550 2608351 + beta-galactosidase SCC24.01%2C possible sugar hydrolase (fragment) ( hypothetical protein)%2C len: >407 aa%3B similar to C-terminal region of SW:BGAL_ASPNG (EMBL:L06037) Aspergillus niger beta galactosidase precursor (EC 3.2.1.23) LacA%2C 1006 aa%3B fasta scores: opt: 214 z-score: 223.7 E(): 5e-05%3B 27.1%25 identity in 321 aa overlap~SCC42.11%2C probable beta-galactosidase (fragment)%2C len: >555 aa%3B similar to SW:BGAL_ASPNG (EMBL:L06037) Aspergillus niger beta-galactosidase precursor (EC 3.2.1.23) LacA%2C 1006 aa%3B fasta scores: opt: 413 z-score: 403.4 E(): 5.4e-15%3B 24.3%25 identity in 608 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2430 SCO2431 SCO2431 abfA abfA 2608364 2609869 - alpha-L-arabinofuranosidase SCC24.02c%2C abfA%2C alpha-L-arabinofuranosidase%2C len: 501 aa%3B almost identical to SW:ABFA_STRLI (EMBL:U04630) Streptomyces lividans alpha-L-arabinofuranosidase (EC 3.2.1.55) AbfA%2C 662 aa gene gene2433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2431 SCO2432 SCO2432 SCC24.03c SCC24.03c 2609897 2610760 - sugar transporter membrane protein SCC24.03c%2C possible sugar transporter membrane protein%2C len: 287 aa%3B similar to TR:CAB59597 (EMBL:AL132662) Streptomyces coelicolor probable sugar transport inner membrane protein SCF11.20%2C 299 aa%3B fasta scores: opt: 673 z-score: 788.9 E(): 0%3B 35.3%25 identity in 278 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene2434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2432 SCO2433 SCO2433 SCC24.04c SCC24.04c 2610757 2611698 - sugar transporter membrane protein SCC24.04c%2C possible sugar transporter membrane protein%2C len: 313 aa%3B similar to TR: CAB59596(EMBL:AL132662) Streptomyces coelicolor probable sugar transporter inner membrane protein SCF11.19%2C 316 aa%3B fasta scores: opt: 533 z-score: 637.4 E(): 4.5e-28%3B 36.2%25 identity in 304 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene2435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2433 SCO2434 SCO2434 SCC24.05c SCC24.05c 2611695 2613053 - sugar transporter sugar binding protein SCC24.05c%2C possible sugar transporter sugar binding protein%2C len: 452 aa%3B similar to TR:CAB59595 (EMBL:AL132662) Streptomyces coelicolor%2C probable sugar transporter sugar binding lipoprotein SCF11.18%2C 442 aa%3B fasta scores: opt: 274 z-score: 320.2 E(): 2.1e-10%3B 23.3%25 identity in 443 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein. Contains possible N-terminal signal peptide sequence gene gene2436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2434 SCO2435 SCO2435 SCC24.06 SCC24.06 2613322 2613849 + hypothetical protein SCC24.06%2C unknown%2C len: 175 aa%3B similar to TR:Q9F1V4 (EMBL:AB041825) Streptomyces ambofaciens ORF1 (genes for calcium binding) hypothetical protein%2C 131 aa%3B fasta scores: opt: 452 Z-score: 555.1 E(): 2.8e-23%3B 64.655%25 identity in 116 aa overlap gene gene2437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2435 SCO2436 SCO2436 SCC24.07 SCC24.07 2613846 2615030 + hypothetical protein SCC24.07%2C possible integral membrane protein%2C len: 394 aa. Contains possible hydrophobic membrane spanning regions gene gene2438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2436 SCO2437 SCO2437 SCC24.08 SCC24.08 2615125 2616336 + hypothetical protein SCC24.08%2C possible integral membrane protein%2C len: 403 aa. Contains possible hydrophobic membrane spanning regions gene gene2439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2437 SCO2438 SCO2438 SCC24.09 SCC24.09 2616326 2617732 + hypothetical protein SCC24.09%2C possible hypothetical protein%2C len: 468 aa%3B similar to various hypothetical proteins%2C e.g. TR:O86550 (EMBL:AL031350) Streptomyces coelicolor hypothetical 50.7 kD protein SC1F2.13c%2C 476 aa%3B fasta scores: opt: 931 z-score: 995.7 E(): 0%3B 43.2%25 identity in 458 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2438 SCO2439 SCO2439 SCC24.10c SCC24.10c 2617790 2618650 - calcium-binding protein SCC24.10c%2C possible calcium-binding protein%2C len: 286 aa%3B similar to TR:BAA90694 (EMBL:AB037936) Xenopus laevis regucalcin%2C 299 aa%3B fasta scores: opt: 449 z-score: 514.7 E(): 3.1e-21%3B 33.8%25 identity in 293 aa overlap gene gene2441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2439 SCO2440 SCO2440 SCC24.11c SCC24.11c 2618647 2619420 - transcriptional regulator SCC24.11c%2C probable transcriptional regulator%2C len: 257 aa%3B similar to SW:KDGR_ECOLI (EMBL:AE000277) Escherichia coli transcriptional regulator KdgR%2C 263 aa%3B fasta scores: opt: 446 z-score: 510.4 E(): 5.4e-21%3B 32.1%25 identity in 249 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator gene gene2442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2440 SCO2441 SCO2441 SCC24.12 SCC24.12 2619547 2620149 + hypothetical protein SCC24.12%2C unknown%2C len: 200 aa. High content in alanine and arginine residues gene gene2443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2441 SCO2442 SCO2442 SCC24.13c SCC24.13c 2620174 2620881 - GntR family transcriptional regulator SCC24.13c%2C probable gntR-family transcriptional regulator%2C len: 235 aa%3B similar to SW:UXUR_ECOLI (EMBL:U14003) Escherichia coli%2C Uxu operon transcriptional regulator UxuR%2C 257 aa%3B fasta scores: opt: 338 z-score: 385.5 E(): 4.9e-14%3B 32.6%25 identity in 236 aa overlap and to TR:CAB6127 (EMBL:AL132991) Streptomyces coelicolor transcriptional regulator SCF55.06%2C 253 aa%3B fasta scores: opt: 380 z-score: 432.1 E(): 1.2e-16%3B 33.1%25 identity in 236 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and match ot Prosite entry S00043 Bacterial regulatory proteins%2C gntR family signature and possible helix-turn-helix motif at residues 37..58 (+3.83 SD) gene gene2444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2442 SCO2443 SCO2443 SCC24.14 SCC24.14 2621091 2622488 + hypothetical protein SCC24.14%2C probable carrier protein (membrane protein)%2C len: 465 aa%3B similar to TR:Q9ZIP4 (EMBL:AF022387) Rhizobium trifolii dicarboxylate carrier protein gene MatC%2C 448 aa%3B fasta scores: opt: 827 z-score: 814.6 E(): 0%3B 51.0%25 identity in 465 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2443 SCO2444 SCO2444 SCC24.15 SCC24.15 2622576 2624033 + acyl-CoA synthetase activates fatty acids by binding to coenzyme A gene gene2446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2444 SCO2445 SCO2445 SCC24.16 SCC24.16 2624026 2625402 + acetyl CoA carboxylase subunits alpha/beta SCC24.16%2C probable acetyl CoA carboxylase (alpha and beta subunits)%2C len: 458 aa%3B N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD%2C 304 aa%3B fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13%3B 32.4%25 identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214%2C 316 aa%3B fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13%3B 39.9%25 identity in 223 aa overlap gene gene2447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2445 SCO2446 SCO2446 SCC24.17c SCC24.17c 2625671 2629333 - peptidase SCC24.17c%2C probable peptidase%2C len: 1220 aa%3B similar to TR:P95684 (EMBL:D83672) Streptomyces albogriseolus subtilisin-like protease%2C 1102 aa%3B fasta scores: opt: 1362 z-score: 1378.8 E(): 0%3B 33.7%25 identity in 1233 aa overlap and to TR:CAB56662 (EMBL:AL121596) Streptomyces coelicolor probable peptidase SCF51A.10%2C 1245 aa%3B fasta scores: opt: 1509 z-score: 1527.2 E(): 0%3B 39.5%25 identity in 1278 aa overlap. Contains Pfam match to entry PF00082 Peptidase_S8%2C Subtilase family and matches to Prosite entries PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site%2C S00137 Serine proteases%2C subtilase family%2C histidine active site and PS00138 Serine proteases%2C subtilase family%2C serine active site. Contains also possible N-terminal region signal peptide sequence gene gene2448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2446 SCO2447 SCO2447 SCC24.18 SCC24.18 2629512 2629973 + hypothetical protein SCC24.18%2C unknown%2C len: 153 aa gene gene2449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2447 SCO2448 SCO2448 SCC24.19 SCC24.19 2629970 2631634 + hypothetical protein SCC24.19%2C unknown%2C len: 554 aa gene gene2450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2448 SCO2449 SCO2449 SCC24.20 SCC24.20 2631773 2632795 + hypothetical protein SCC24.20%2C conserved hypothetical protein%2C len: 340 aa%3B similar to TR:Q9F3J5 (EMBL:AL391763) Streptomyces coelicolor conserved hypothetical protein 340 aa%3B fasta scores: opt: 1113 Z-score: 1094.9 E(): 2.4e-53%3B 54.519%25 identity in 343 aa overlap gene gene2451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2449 SCO2450 SCO2450 SCC24.21 SCC24.21 2632795 2636844 + Ser/Thr protein kinase (regulator) SCC24.21%2C possible Ser/Thr protein kinase (regulator)%2C len: 1349 aa%3B N-terminal region similar to SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr protein kinase PkaB%2C 417 aa%3B blastp socres: Score %3D 109 (38.4 bits)%2C Expect %3D 0.00070%2C Sum P(2) %3D 0.00070 Identities %3D 39/121 (32%25)%2C Positives %3D 60/121 (49%25) and C-teminal region similar to SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR%2C 993 aa%3B fasta scores: opt: 510 z-score: 438.0 E(): 5.8e-17%3B 33.3%25 identity in 442 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain gene gene2452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2450 SCO2451 SCO2451 SCC24.22 SCC24.22 2637014 2638096 + rod shape-determining protein MreB SCC24.22%2C probable rod shape-determining protein%2C len: 360 aa%3B similar to SW:MREB_BACSU (EMBL:M95582) Bacillus subtilis rod-shape determining protein MreB%2C 337 aa%3B fasta scores: opt: 740 z-score: 810.4 E(): 0%3B 34.8%25 identity in 322 aa overlap and to TR:CAB75392 (EMBL:AL139298) Streptomyces coelicolor rod shape-determining protein MreB%2C 343 aa%3B fasta scores: opt: 868 z-score: 835.5 E(): 0%3B 43.1%25 identity in 320 aa overlap gene gene2453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2451 SCO2452 SCO2452 SCC24.23 SCC24.23 2638132 2639559 + two-component sensor histidine kinase SCC24.23%2C possible two-component sensor histidine kinase%2C len: 475 aa%3B similar to TR:Q9ZBY4 (EMBL:AL034355) Streptomyces coelicolor two-component sensor SCD78.15%2C 560 aa%3B fasta scores: opt: 1304 z-score: 1399.9 E(): 0%3B 46.9%25 identity in 510 aa overlap and to C-terminal region to C-terminal region of TR:Q9Z678 (EMBL:AF10227) Streptomyces coelicolor sensor-histidine kinase%2C 398 aa%3B fasta scores: opt: 158 z-score: 174.4 E(): 0.028%3B 31.9%25 identity in 182 aa overlap. Contains Pfam match to entry PF01590 GAF%2C GAF domain gene gene2454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2452 SCO2453 SCO2453 SCC24.24 SCC24.24 2639574 2639792 + hypothetical protein SCC24.24%2C unknown%2C len: 72 aa. High content in glycine and proline amino acid residues gene gene2455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2453 SCO2454 SCO2454 SCC24.25 SCC24.25 2640001 2642232 + hypothetical protein SCC24.25%2C possible integral membrane protein%2C len: 743 aa%3B similar to SW:MMLC_STRCO (EMBL:AL031107) Streptomyces coelicolor membrane protein SC5A7.16c%2C 705 aa%3B fasta scores: opt: 765 z-score: 808.9 E(): 0%3B 37.9%25 identity in 737 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membane spanning regions gene gene2456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2454 SCO2455 SCO2455 SCC24.26c SCC24.26c 2642344 2643939 - spermidine synthase catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine gene gene2457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2455 SCO2456 SCO2456 SCC24.27c SCC24.27c 2644019 2644459 - hypothetical protein SCC24.27c%2C possible integral membrane protein%2C len: 146 aa%3B similar to SW:Y0B1_MYCTU (EMBL:Z77724) Mycobacterium tuberculosis hypothetical 13.7 kD protein CY227.01c%2C MTCY227.01c%2C 133 aa%3B fasta scores: opt: 241 z-score: 297.9 E(): 3.7e-09%3B 34.8%25 identity in 135 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2456 SCO2457 SCO2457 SCC24.28c SCC24.28c 2644511 2644906 - lipoprotein SCC24.28c%2C possible lipoprotein%2C len: 131 aa%3B similar to SW:Y0B2_MYCTU (EMBL:Z77724) Mycobacterium tuberculosis hypothetical 15.0 kD protein CY227.02c precursor%2C MTCY227.02c%2C 143 aa%3B fasta scores: opt: 130 z-score: 169.2 E(): 0.054%3B 26.5%25 identity in 136 aa overlap. Contains match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene2459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2457 SCO2458 SCO2458 SCC24.29c SCC24.29c 2644903 2645421 - hypothetical protein SCC24.29c%2C hypothetical protein%2C len: 172 aa%3B similar to TR:Q9X8S3 (EMBL:AL049754) Streptomyces coelicolor hypothetical 20.1 kD protein SCH10.34c%2C 185 aa%3B fasta scores: opt: 412 z-score: 505.6 E(): 1e-20%3B 40.7%25 identity in 172 aa overlap gene gene2460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2458 SCO2459 SCO2459 SCC24.30 SCC24.30 2645538 2646071 + hypothetical protein SCC24.30%2C unknown%2C len: 177 aa gene gene2461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2459 SCO2460 SCO2460 SCC24.31c SCC24.31c 2646222 2646650 - hypothetical protein SCC24.31c%2C hypothetical protein%2C len: 142 aa%3B similar to TR:O06633 (EMBL:Z95618) Mycobacterium tuberculosis hypothetical 12.5 kD protein MTCY07H7A.08c%2C 115 aa%3B fasta scores: opt: 109 z-score: 150.6 E(): 0.59%3B 35.0%25 identity in 140 aa overlap gene gene2462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2460 SCO2461 SCO2461 SCC24.32 SCC24.32 2647411 2647737 + hypothetical protein SCC24.32%2C possible hypothetical protein%2C len: 108 aa. Contains possible N-terminal region signal peptide sequence gene gene2466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2461 SCO2462 SCO2462 SC7A8.01 SC7A8.01 2647782 2649230 + sugar kinase SC7A8.01%2C probable sugar kinase (fragment)%2C len: >434 aa%3B similar to TR:CAB61582 (EMBL:AL133210) Streptomyces coelicolor xylulose kinase (fragment) XylB%2C 432 aa%3B fasta scores: opt: 822 z-score: 871.9 E(): 0%3B 38.8%25 identity in 418 aa overlap and to SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) XylB%2C 481 aa%3B fasta scores: opt: 814 z-score: 862.8 E(): 0%3B 39.5%25 identity in 423 aa overlap . Contains Pfam match to entry PF00370 FGGY%2C FGGY family of carbohydrate kinases and PS00445 FGGY family of carbohydrate kinases signature 2~SCC24.33%2C probable sugar kinase (fragment)%2C len: >82 aa%3B similar to SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) XylB%2C 481 aa%3B fasta scores: opt: 135 z-score: 170.4 E(): 0.05%3B 34.1%25 identity in 82 aa overlap gene gene2467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2462 SCO2463 SCO2463 SC7A8.02 SC7A8.02 2649370 2651103 + ABC transporter SC7A8.02%2C probable ABC transporter%2C len: 577 aa%3B similar to TR:Q9WYC3 (EMBL:AE001710) Thermotoga maritima ABC transporter%2C ATP-binding protein%2C 577 aa%3B fasta scores: opt: 1411 z-score: 1575.1 E(): 0%3B 39.9%25 identity in 569 aa overlap and to SW:YC73_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein RV1273c%2C 582 aa%3B fasta scores: opt: 1966 z-score: 2193.8 E(): 0%3B 51.7%25 identity in 574 aa overlap. Contains Pfam two matches to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region and two matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene2468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2463 SCO2464 SCO2464 SC7A8.03 SC7A8.03 2651103 2653031 + ABC transporter SC7A8.03%2C probable ABC transporter%2C len: 642 aa%3B similar to TR:Q9WYC4 (EMBL:AE001710) Thermotoga maritima ABC transporter%2C ATP-binding protein%2C 598 aa%3B fasta scores: opt: 1520 z-score: 1587.7 E(): 0%3B 40.3%25 identity in 613 aa overlap and to SW:YC72_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein RV1273c%2C 631 aa%3B fasta scores: opt: 2325 z-score: 2426.2 E(): 0%3B 57.6%25 identity in 632 aa overlap. Contains two Pfam matches to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region and two matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene2469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2464 SCO2465 SCO2465 hrdA hrdA 2653137 2654327 - RNA polymerase principal sigma factor SC7A8.04c%2C hrdA%2C RNA polymerase principal sigma factor%2C len: 396 aa%3B identical to previously sequenced SW:HRDA_STRCO (EMBL:X52980) Streptomyces coelicolor RNA polymerase principal sigma factor HrdA%2C 396 aa and highly similar to SW:RPSD_STRAU (EMBL:M90410) Streptomyces aureofaciens RNA polumerase sigma factor RpoD%2C 317 aa%3B fasta scores: opt: 1792 z-score: 1762.6 E(): 0%3B 89.9%25 identity in 316 aa overlap and to S. coelicolor SC5B8.10%2C 511 aa%3B fasta scores: opt: 1276 z-score: 1056.4 E(): 0%3B 51.6%25 identity in 397 aa overlap. Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and two matches to Prosite entries PS00715 Sigma-70 factors family signature 1 and PS00716 Sigma-70 factors family signature 2. Contains also a possible helix-turn-helix motif at residues 355..376 (+6.21 SD) gene gene2470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2465 SCO2466 SCO2466 SC7A8.05 SC7A8.05 2654512 2655117 + hypothetical protein SC7A8.05%2C hypothetical protein%2C len: 201 aa%3B identical to C-terminus of previously sequenced TR:CAB51553 (EMBL:AJ244019) Streptomyces coelicolor A3(2) hypothetical 14.6 kD protein%2C 132 aa gene gene2471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2466 SCO2467 SCO2467 SC7A8.06 SC7A8.06 2655114 2656115 + hypothetical protein SC7A8.06%2C hypothetical protein%2C len: 333 aa%3B identical to previously sequenced TR:CAB51552 (EMBL:AJ244019) Streptomyces coelicolor A3(2) hypothetical 37.1 kD protein%2C 333 aa gene gene2472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2467 SCO2468 SCO2468 dnaG dnaG 2656131 2658056 - DNA primase synthesizes RNA primers at the replication forks gene gene2473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2468 SCO2469 SCO2469 SC7A8.08c SC7A8.08c 2658086 2659351 - reductase SC7A8.08c%2C probable reductase%2C len: 421 aa%3B identical to previously sequenced TR:CAB51550 (EMBL:AJ244019) Streptomyces coelicolor A3(2) dnaG gene and flanking genes and similar to SW:CAMA_PSEPU (EMBL:J05406) Pseudomonas putida putidaredoxin reductase (EC 1.18.1.-) CamA%2C 422 aa%3B fasta scores: opt: 805 z-score: 922.5 E(): 0%3B 35.8%25 identity in 422 aa overlap gene gene2474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2469 SCO2470 SCO2470 SC7A8.09c SC7A8.09c 2659480 2660754 - deoxyguanosinetriphosphate triphosphohydrolase-like protein dGTPase family type 2 subfamily%3B presumably hydrolyzes dGTP to deoxyguanosine and triphosphate gene gene2475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2470 SCO2471 SCO2471 SC7A8.10c SC7A8.10c 2660813 2661637 - hypothetical protein SC7A8.10c%2C possible hypothetical protein%2C len: 274 aa%3B similar to various hypothetical proteins%2C e.g. TR:P95216 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical 26.2 kD protein%2C 247 aa%3B fasta scores: opt:413 z-score: 450.1 E(): 1.1e-17%3B 34.5%25 identity in 232 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2471 SCO2472 SCO2472 SC7A8.11 SC7A8.11 2661818 2662504 + hypothetical protein SC7A8.11%2C possible integral membrane protein%2C len: 228 aa%3B similar to SW:YGJQ_ECOLI (EMBL:U18997) Escherichia coli hypothetical 25%2C5 kD protein%2C 230 aa%3B fasta scores: opt: 405 z-score: 493.9 E(): 4e-20%3B 37.7%25 identity in 207 aa overlap and to SW:SANA_ECOLI (EMBL:Z47804) Escherichia coli SanA protein%2C 239 aa%3B fasta scores: opt: 328 z-score: 401.5 E(): 5.7e-15%3B 34.7%25 identity in 170 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2472 SCO2473 SCO2473 SC7A8.12 SC7A8.12 2662608 2665067 + nitrate reductase SC7A8.12%2C probable nitrate reductase%2C len: 819 aa%3B similar to SW:NASC_BACSU (EMBL:D50453) Bacillus subtilis assimilatory nitrate reductase catalytic subunit (EC 1.7.99.4) NasC%2C 710 aa%3B fasta scores: opt: 1568 z-score: 1572.1 E(): 0%3B 37.9%25 identity in 816 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding%2C Molydopterin dinucleotide binding domain. Contains also glycine/serine rich region gene gene2478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2473 SCO2474 SCO2474 SC7A8.13 SC7A8.13 2665196 2666839 + metalloproteinase SC7A8.13%2C probable metalloproteinase (hypothetical protein)%2C len: 547 aa%3B similar to TR:O06694 (EMBL:U50548) Vibrio vulnificus metalloprotease%2C 606 aa%3B fasta scores: opt: 493 z-score: 516.9 E(): 2.1e-21%3B 31.5%25 identity in 461 aa overlap and to SW:PROA_LEGPN (EMBL:M31884) Legionella pneumophila zinc metalloproteinase precursor (EC 3.4.24.-) ProA%2C 543 aa%3B fasta scores: opt: 475 z-score: 498.8 E(): 2.1e-20%3B 31.4%25 identity in 417 aa overlap. Contains Pfam match to entry PF01447 Peptidase_M4%2C Thermolysin family peptidase and match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Contains also possible N-terminal region signal peptide sequence gene gene2479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2474 SCO2475 SCO2475 SC7A8.14 SC7A8.14 2666940 2667869 + LysR family transcriptional regulator SC7A8.14%2C probable lysR-family transcriptional regulator%2C len: 309 aa%3B similar to TR:O06466 (EMBL:U94336) Xanthomonas campestris oxidative stress transcriptional regulator OxyR%2C 313 aa%3B fasta scores: opt: 374 z-score: 419.6 E(): 5.5e-16%3B 29.7%25 identity in 316 aa overlap and SW:OXYR_MYCLE (EMBL:L01095) Mycobacterium leprae probable hydrogen peroxide-inducible genes activator OxyR%2C 311 aa%3B fasta scores: opt: 375 z-score: 420.8 E(): 4.8e-16%3B 33.7%25 identity in 246 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains a possible helix-turn-helix motif at residues 16..37 (+3.82 SD) gene gene2480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2475 SCO2476 SCO2476 SC7A8.15c SC7A8.15c 2667818 2668561 - dehydrogenase/reductase SC7A8.15c%2C probable dehydrogenase/reductase ( hypothetical protein)%2C len: 247 aa%3B similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor oxidoreductase SCJ11.40%2C 250 aa%3B fasta scores: opt: 591 z-score: 665.9 E(): 1.1e-29%3B 43.1%25 identity in 246 aa overlap and to SW:2BHD_STREX AC:P19992 Streptomyces exfoliatus (Streptomyces hydrogenans) 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53)%2C 25 aa%3B fasta scores: opt: 414 z-score: 469.7 E(): 9e-19%3B 36.1%25 identity in 249 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature. Contains also possible N-terminal region signal peptide sequence gene gene2481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2476 SCO2477 SCO2477 SC7A8.16c SC7A8.16c 2668624 2669391 - short chain dehydrogenase gene gene2482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2477 SCO2478 SCO2478 SC7A8.17c SC7A8.17c 2669524 2670111 - reductase SC7A8.17c%2C possible reductase%2C len: 195 aa%3B similar to TR:Q9ZGD0 (EMBL:AF080235) Streptomyces cyanogenus reductase homolog LanO%2C 193 aa%3B fasta scores: opt: 780 z-score: 927.8 E(): 0%3B 60.1%25 identity in 188 aa overlap and to TR:AAF00220 (EMBL:AF164961) Streptomyces fradiae UrdO%2C 197 aa%3B fasta scores: opt: 775 z-score: 921.8 E(): 0%3B 55.7%25 identity in 194 aa overlap gene gene2483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2478 SCO2479 SCO2479 SC7A8.18 SC7A8.18 2670321 2670863 + hypothetical protein SC7A8.18%2C possible membrane protein%2C len: 180 aa. Contains possible hydrophobic membrane spanning regions both at N- and C-terminal domains gene gene2484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2479 SCO2480 SCO2480 SC7A8.19 SC7A8.19 2670982 2671614 + hypothetical protein SC7A8.19%2C possible hypothetical protein%2C len: 210 aa. Similar to Streptomyces coelicolor SCM10.24%2C 221 aa%3B fasta scores: opt: 672 z-score: 568.7 E(): 2.9e-26%3B 50.2%25 identity in 211 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2480 SCO2481 SCO2481 SC7A8.20c SC7A8.20c 2671552 2671941 - hypothetical protein SC7A8.20c%2C hypothetical protein%2C len: 129 aa%3B similar to various hypothetical proteins%2C e.g. SW:YYBR_BACSU (EMBL:D26185) Bacillus subtilis hypothetical 14.7 kD protein in CotF-TetB intergenic region YybR%2C 125 aa%3B fasta scores: opt: 333 z-score: 424.6 E(): 2.9e-16%3B 45.5%25 identity in 112 aa overlap and to Streptomyces coelicolor SC7A1.18c%2C 141 aa%3B fasta scores: opt: 243 z-score: 270.7 E(): 1.1e-09%3B 49.4%25 identity in 77 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function gene gene2486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2481 SCO2482 SCO2482 SC7A8.21 SC7A8.21 2672049 2672984 + dehydrogenase SC7A8.21%2C possible dehydrogenase (hypothetical protein)%2C len: 311 aa%3B similar to various hypothetical dehydrogenases%2C e.g. TR:Q9YE14 (EMBL:AP000060) Aeropyrum pernix 287 aa long hypothetical 3-hydroxyisobutyrate dehydrogenase APE0756%2C 287 aa%3B fasta scores: opt: 196 z-score: 223.5 E(): 4.7e-05%3B 27.0%25 identity in 293 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2482 SCO2483 SCO2483 SC7A8.22 SC7A8.22 2673003 2673713 + hypothetical protein SC7A8.22%2C possible hypothetical protein%2C len: 236 aa. Contains possible N-terminal region signal peptide sequence gene gene2488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2483 SCO2484 SCO2484 SC7A8.23 SC7A8.23 2673743 2675029 + hypothetical protein SC7A8.23%2C possible hypothetical protein%2C len: 428 aa%3B similar to TR:O86542 (EMBL:AL031350) Streptomyces coelicolor hypothetical protein SC1F2.05%2C 552 aa%3B fasta scores: opt: 440 z-score: 473.6 E(): 5.5e-19%3B 32.3%25 identity in 406 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2484 SCO2485 SCO2485 SC7A8.24c SC7A8.24c 2675087 2675869 - hypothetical protein SC7A8.24c%2C hypothetical protein%2C len: 242 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB54589 (EMBL:AJ249205) Vibrio cholerae hypothetical 27.3 kD protein%2C 261 aa%3B fasta scores: opt: 509 z-score: 568.8 E(): 2.7e-24%3B 35.5%25 identity in 256 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2485 SCO2486 SCO2486 nirB nirB 2676046 2677278 + nitrite reductase NirB SC7A8.25%2C nirB%2C probable nitrite reductase%2C len: 410 aa%3B similar to N-terminal region of TR:O53674 (EMBL:AL021929) Mycobacterium tuberculosis nitrite reductase large subunit NirB%2C 853 aa%3B fasta scores: opt: 657 z-score: 711.6 E(): 3e-32%3B 37.8%25 identity in 431 aa overlap and to SW:NIRB_KLEPN (EMBL:L06800) Klebsiella pneumoniae nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NasB%2C 957 aa%3B fasta scores: opt: 636 z-score: 688.3 E(): 6e-3%3B 35.4%25 identity in 412 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2486 SCO2487 SCO2487 nirB nirB 2677278 2679893 + nitrite reductase large subunit NirB SC7A8.26%2C nirB%2C probable nitrite reductase large subunit%2C len: 871 aa%3B similar to TR:Q00943 (EMBL:Z68122) Pichia angusta nitrite reductase Yni1%2C 1044 aa%3B fasta scores: opt: 1960 z-score: 2117.6 E(): 0%3B 43.2%25 identity in 868 aa overlap and SW:NIRB_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NirB 847 aa%3B fasta scores:opt: 1609 z-score: 1739.1 E(): 0%3B 52.1%25 identity in 845 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR%2C Nitrite and sulphite reductase and two matches to Prosite entries PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site and PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site gene gene2492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2487 SCO2488 SCO2488 nirC nirC 2679896 2680291 + nitrite reductase small subunit NirC SC7A8.27%2C nirC%2C probable nitrite reductase small subunit%2C len: 131 aa%3B similar to TR:O53675 (EMBL:AL021929) Mycobacterium tuberculosis nitrite reductase small subunit NirD%2C 118 aa%3B fasta scores: opt: 353 z-score: 455.1 E(): 5.9e-18%3B 56.5%25 identity in 92 aa overlap and to SW:NIRD_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4) NirD%2C 108 aa%3B fasta scores: opt: 265 z-score: 346.0 E(): 7e-12%3B 46.9%25 identity in 96 aa overlap gene gene2493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2488 SCO2489 SCO2489 SC7A8.28 SC7A8.28 2680340 2680924 + TetR family transcriptional regulator SC7A8.28%2C probable tetR-family transcriptional regulator%2C len: 194 aa%3B similar to TR:CAB53122 (EMBL:AL109962) Streptomyces coelicolor transcriptional regulatory protein SCJ1.04%2C aa%3B fasta scores: opt: 184 z-score: 231.2 E(): 1.7e-05%3B 30.9%25 identity in 162 aa overlap and to SW:YCFQ_ECOLI (EMBL:AE000211) Escherichia coli hypothetical transcriptional regulator in NDH-MFD intergenic region YcfQ%2C 210 aa%3B fasta scores: opt: 282 z-score: 348.3 E(): 5.2e-12%3B 32.3%25 identity in 192 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 28..49 (+3.04 SD) gene gene2494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2489 SCO2490 SCO2490 SC7A8.29 SC7A8.29 2681005 2681772 + dehydrogenase SC7A8.29%2C probable dehydrogenase (hypothetical protein)%2C len: 255 aa%3B similar to TR:O88068 (EMBL:AL031541) Streptomyces coelicolor dehydrogenase SCI35.33c%2C 260 aa%3B fasta scores: opt: 536 z-score: 554.4 E(): 1.7e-23%3B 40.0%25 identity in 255 aa overlap and to SW:DHG2_BACSU (EMBL:AB000617)Bacillus subtilis glucose 1-dehydrogenase II (EC 1.1.1.47) (GlcDH-II) (Gdh-II) (general stress protein 74) (Gsp74) YcdF%2C 258 aa%3B fasta scores: opt: 566 z-score: 584.7 E(): 3.5e-25%3B 39.3%25 identity in 252 aa overlap Contains two Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and possible N-terminal region signal peptide sequence gene gene2495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2490 SCO2491 SCO2491 SC7A8.30c SC7A8.30c 2681817 2682749 - oxidoreductase SC7A8.30c%2C probable oxidoreductase%2C len: 310 aa%3B similar to TR:O53726 (EMBL:AL021932) Mycobacterium tuberculosis oxidoreductase MTV037.03c%2C 311 aa%3B fasta scores: opt: 827 z-score: 914.1 E(): 0%3B 49.3%25 identity in 306 aa overlap%2C to SW:OXIR_STRAT (EMBL:M96551) Streptomyces antibioticus probable oxidoreductase (EC 1.-.-.-)%2C 298 aa%3B fasta scores: opt: 427 z-score: 476.5 E(): 3.7e-19%3B 37.2%25 identity in 293 aa overlap and to S. coelicolor SCJ9A.19c%2C 311 aa%3B fasta scores: opt: 729 z-score: 645.5 E(): 1.5e-30%3B 44.5%25 identity in 310 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene2496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2491 SCO2492 SCO2492 SC7A8.31 SC7A8.31 2682933 2683406 + hypothetical protein SC7A8.31%2C possible membrane protein%2C len: 157 aa. Contains possible N-terminal region signal peptide sequence and C-terminal region possible hydrophobic membrane spanning region gene gene2497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2492 SCO2493 SCO2493 SC7A8.32c SC7A8.32c 2683469 2684677 - hypothetical protein SC7A8.32c%2C probable membrane protein%2C len: 402 aa%3B similar to TR:Q9WX28 (EMBL:AL079345) Streptomyces coelicolor membrane protein SCE68.03%2C 441 aa%3B fasta scores: opt: 1057 z-score: 1265.9 E(): 0%3B 44.8%25 identity in 384 aa overlap and SW:MDMB_STRMY (EMBL:M93958) Streptomyces mycarofaciens acyltransferase (EC 2.3.1.-) MdmB%2C 387 aa%3B fasta scores: opt: 211 z-score: 255.4 E(): 7.8e-07%3B 25.6%25 identity in 406 aa overlap gene gene2498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2493 SCO2494 SCO2494 SC7A8.33c SC7A8.33c 2684904 2687633 - pyruvate phosphate dikinase catalyzes the formation of phosphoenolpyruvate from pyruvate gene gene2499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2494 SCO2495 SCO2495 SC7A8.34 SC7A8.34 2688116 2689894 + hypothetical protein SCC82.01%2C unknownm len: >83 aa~SC7A8.34%2C possible membrane protein (fragment)%2C len: >541 aa. Contains possible hydrophobic membrane spanning regions gene gene2500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2495 SCO2496 SCO2496 SCC82.02 SCC82.02 2690016 2690456 + hypothetical protein SCC82.02%2C possible hypothetical protein%2C len: 146 aa. Contains possible N-terminal region signal peptide sequence gene gene2501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2496 SCO2497 SCO2497 SCC82.03c SCC82.03c 2690476 2691696 - hypothetical protein SCC82.03c%2C hypothetical protein%2C len: 406 aa%3B similar to varous hypothetical proteins%2C e.g. SW:Y823_MYCTU (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 41.4 kD protein RV0823c%2C 389 aa%3B fasta scores: opt: 1153 z-score: 1349.3 E(): 0%3B 56.2%25 identity in 406 aa overlap. Contains Pfam match to entry PF01207 UPF0034%2C Uncharacterized protein family UPF0034 and match to Prosite entry PS01136 Uncharacterized protein family UPF0034 signature gene gene2502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2497 SCO2498 SCO2498 SCC121.01 SCC121.01 2691805 2693250 + efflux protein SCC121.01%2C probable efflux membrane protein%2C len: >344 aa%3B similar to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA%2C 538 aa%3B fasta scores: opt: 654 z-score: 718.1 E(): 1.3e-32%3B 38.7%25 identity in 305 aa overlap~SCC82.04%2C possible efflux protein%2C len: >168 aa%3B similar to TR:CAB55652 (EMBL:AL117385) Streptomyces coelicolor transmembrane efflux protein%2C SC5G9.04c%2C 489 aa%3B fasta scores: opt: 564 z-score: 675.1 E(): 3.3e-30%3B 46.9%25 identity in 160 aa overlap and to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii (Streptomyces alboniger)puromycin resistance protein Pur8%2C 503 aa%3B fasta scores: opt: 454 z-score: 544.8 E(): 5.9e-23%3B 44.7%25 identity in 159 aa overlap. Contains N-terminal region signal peptide sequence and match to Prosite entry PS00216 Sugar transport proteins signature 1 gene gene2503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2498 SCO2499 SCO2499 SCC121.02c SCC121.02c 2693290 2697708 - transport ATPase SCC121.02c%2C possible transport ATPase%2C len: 1472 aa%3B similar to TR:P96271 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 159.8 kD protein MTCY22G10.22c%2C 1539 aa%3B fasta scores: opt: 2216 z-score: 2157.1 E(): 0%3B 38.4%25 identity in 1543 aa overlap and N-terminal region similar to SW:ATMA_SALTY (EMBL:U07843) Salmonella typhimurium Mg(2+) transport atpase%2C P-type 1 (EC 3.6.1.-) MgtA%2C 902 aa%3B fasta scores: opt: 800 z-score: 779.8 E(): 0 %3B28.0%25 identity in 880 aa overlap. Contains Pfam match to entry PF00122 E1-E2_ATPase%2C match to Prosite entry PS00154 E1-E2 ATPases phosphorylation site and possible N-terminal region signal peptide sequence gene gene2504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2499 SCO2500 SCO2500 SCC121.03 SCC121.03 2697734 2698408 + hypothetical protein SCC121.03%2C possible membrane protein%2C len: 142 aa gene gene2505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2500 SCO2501 SCO2501 SCC121.04c SCC121.04c 2698679 2699575 - DNA-binding protein SCC121.04c%2C possible DNA-binding protein%2C len: 298 aa%3B similar to TR:CAB52924 (EMBL:AL109949) Streptomyces coelicolor DNA-binding protein SCJ11.39c%2C 279 aa%3B fasta scores: opt: 713 z-score: 847.3 E(): 0%3B 44.0%25 identity in 266 aa overlap and to TR:CAB53273 (EMBL:AL109972) Streptomyces coelicolor DNA-binding protein SCJ9A.12c%2C 279 aa%3B fasta scores: opt: 416 z-score: 497.4 E(): 2.6e-20%3B 35.1%25 identity in 276 aa overlap gene gene2506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2501 SCO2502 SCO2502 SCC121.05 SCC121.05 2699686 2701119 + transporter SCC121.05%2C probable transport protein%2C len: 477 aa%3B similar to SW:AC22_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhodin transporter ActII-2%2C 578 aa%3B fasta scores: opt: 902 z-score: 985.8 E(): 0%3B 36.6%25 identity in 437 aa overlap and to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii (Streptomyces alboniger) Puromycin resistance protein Pur8%2C 503 aa%3B fasta scores: opt: 700 z-score: 766.7 E(): 0%3B 34.1%25 identity in 440 aa overlap gene gene2507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2502 SCO2503 SCO2503 SCC121.06 SCC121.06 2701242 2702318 + chitinase SCC121.06%2C probable chitinase precursor%2C len: 358 aa%3B similar to C-terminal region of SW:CHID_BACCI (EMBL:D10594) Bacillus circulans chitinase D precursor (EC 3.2.1.14) ChiD%2C 497 aa%3B fasta scores: opt: 471 z-score: 502.4 E(): 1.4e-20%3B 33.0%25 identity in 370 aa overlap and to SW:CHIX_STROI (EMBL:X71080) Streptomyces olivaceoviridis (Streptomyces corchorusii exochitinase 1 precursor (EC 3.2.1.14) Chi01%2C 597 aa%3B fasta scores: opt: 249 z-score: 267.3 E(): 1.7e-07%3B 31.2%25 identity in 391 aa overlap. Contains Pfam match to entry PF00704 Glyco_hydro_18 and match to Prosite enry PS01095 Chitinases family 18 active site. Contains also possible N-terminal region signal peptide sequence gene gene2508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2503 SCO2504 SCO2504 glyS glyS 2702461 2703843 - glycyl-tRNA synthetase Catalyzes a two-step reaction%2C first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene2509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2504 SCO2505 SCO2505 SCC121.08 SCC121.08 2704004 2704990 + ABC-transporter metal-binding lipoprotein SCC121.08%2C probable ABC-transporter metal-binding lipoprotein%2C len: 328 aa%3B similar to TR:O05703 (EMBL:Z71552) Streptococcus pneumoniae AdcA protein (fragment)%2C 423 aa%3B fasta scores: opt: 551 z-score: 603.5 E(): 3.2e-26%3B 39.7%25 identity in 305 aa overlap and to SW:ZNUA_ECOLI (EMBL:U38702) Escherichia coli%2C high-affinity zinc uptake system protein ZnuA precursor ZnuA%2C 328 aa%3B fasta scores: opt: 294 z-score: 327.0 E(): 8e-11%3B 26.5%25 identity in 283 aa overlap. Contains Pfam match to entry PF01297 Lipoprotein_4 and match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene2510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2505 SCO2506 SCO2506 SCC121.09 SCC121.09 2705052 2705822 + metal transport ABC transporter SCC121.09%2C probable metal transport ABC transporter%2C len: 256 aa%3B similar to TR:Q9XDA6 (EMBL:AF104349) Listeria monocytogenes ABC transporter ZurA%2C 257aa%3B fasta scores: opt: 468 z-score: 522.7 E(): 1e-21%3B 38.0%25 identity in 237 aa overlap and to SW:FHUC_ECOLI (EMBLX05810:) Escherichia coli ferrichrome transport ATP-binding protein FhuC%2C 265 aa%3B fasta scores: opt: 416 z-score: 465.6 E(): 1.5e-18%3B 34.8%25 identity in 256 aa overlap. Contains Pfam match to entry PF00005 ABC_tran and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene2511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2506 SCO2507 SCO2507 SCC121.10 SCC121.10 2705836 2706738 + metal transport ABC transporter SCC121.10%2C probable metal transport ABC transporter%2C len: 300 aa%3B similar to TR:Q9XDA5 (EMBLAF104349:) Listeria monocytogenes hydrophobic membrane protein ZurM%2C 295aa fasta scores: opt: 608 z-score: 697.8 E(): 1.8e-31%3B 34.7%25 identity in 288 aa overlap and to SW:ZNUB_ECOLI (EMBL:AE000280) Escherichia coli high-affinity Zinc uptake system membrane protein ZnuB%2C 261 aa%3B fasta scores: opt: 397 z-score: 459.6 E(): 3.3e-18%3B 27.3%25 identity in 245 aa overlap. Contains Pfam match to entry PF00950 ABC-3 gene gene2512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2507 SCO2508 SCO2508 SCC121.11 SCC121.11 2706801 2707220 + metal uptake regulation protein SCC121.11%2C probable metal uptake regulation protein%2C len: 139 aa%3B similar to TR:O05839 (EMBL:Z95208) Mycobacterium tuberculosis cosmid Y27 Fur%2C 130 aa%3B fasta scores: opt: 546 z-score: 663.0 E(): 1.5e-29%3B 61.8%25 identity in 123 aa overlap and to SW:FUR_NEIGO (EMBL:L11361) Neisseria gonorrhoeae ferric uptake regulation protein (ferric uptake regulator) Fur%2C 144 aa%3B fasta scores: opt: 273 z-score: 339.0 E(): 1.7e-11%3B 35.5%25 identity in 110 aa overlap. Contains Pfam match to entry PF01475 FUR gene gene2513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2508 SCO2509 SCO2509 SCC121.12c SCC121.12c 2707331 2708164 - UDP phosphate synthetase SCC121.12c%2C uppS%2C UDP phosphate synthetase%2C len: 277 aa%3B similar to SW:UPPS_MYCTU (EMBL:Z95208) Mycobacterium tuberculosis UDP pyrophosphate synthetase (EC 2.5.1.31) (Upp synthetase) UppS%2C 296 aa%3B fasta scores: opt: 1144 z-score: 1315.8 E(): 0%3B 63.6%25 identity in 247 aa overlap and to SW:UPPS_ECOLI (EMBL:D83536) Escherichia coli UDP pyrophosphate synthetase (EC 2.5.1.31) (Upp synthetase) UppS%2C 253 aa%3B fasta scores: opt: 642 z-score: 743.0 E(): 0%3B 43.1%25 identity in 232 aa overlap. Contains Pfam match to entry PF01255 UPF0015 gene gene2514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2509 SCO2510 SCO2510 recO recO 2708177 2708932 - DNA repair protein RecO involved in DNA repair and RecFOR pathway recombination%3B RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA gene gene2515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2510 SCO2511 SCO2511 SCC121.14c SCC121.14c 2708946 2709167 - hypothetical protein SCC121.14c%2C unknown%2C len: 73 aa gene gene2516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2511 SCO2512 SCO2512 SCC121.15c SCC121.15c 2709164 2709370 - hypothetical protein SCC121.15c%2C unknown%2C len: 68 aa gene gene2517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2512 SCO2513 SCO2513 SCC121.16 SCC121.16 2709485 2710318 + hypothetical protein SCC121.16%2C hypothetical protein%2C len: 277 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9X8M2 (EMBL:AL049628) Streptomyces coelicolor hypothetical 31.5 kD protein SCE94.16c%2C 280 aa%3B fasta scores: opt: 538 z-score: 655.5 E(): 4.1e-29%3B 37.1%25 identity in 259 aa overlap gene gene2518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2513 SCO2514 SCO2514 SCC121.17 SCC121.17 2710300 2710590 + hypothetical protein SCC121.17%2C hypothetical protein%2C len: 96 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9Z544 (EMBL:AL035212) Streptomyces coelicolor hypothetical 8.2 kD protein SC9B2.15c%2C 77 aa%3B fasta scores: opt: 230 z-score: 304.4 E(): 1.5e-09%3B 48.1%25 identity in 79 aa overlap gene gene2519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2514 SCO2515 SCO2515 SCC121.18 SCC121.18 2710619 2711158 + lipoprotein SCC121.18%2C possible lipoprotein%2C len: 179 aa%3B similar to TR:O86780 (EMBL:AL031317) Streptomyces coelicolor lipoprotein SC6Ga.17%2C 268 aa%3B fasta scores: opt: 145 z-score: 162.0 E(): 0.12%3B 32.1%25 identity in 134 aa overlap. Contains match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene2520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2515 SCO2516 SCO2516 SCC121.19 SCC121.19 2711253 2712752 + hypothetical protein SCC121.19%2C possible hypothetical protein%2C len: 499 aa%3B similar to TR:O69831 (EMBL:AL023517) Streptomyces coelicolor protease SC1B5.03C%2C 543 aa%3B fasta scores: opt: 772 z-score: 821.6 E(): 0%3B 32.2%25 identity in 537 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2516 SCO2517 SCO2517 SCC121.20c SCC121.20c 2712740 2713423 - two-component system response regulator SCC121.20c%2C possible two-component system response regulator%2C len: 227 aa%3B similar to various S. coelicolor two-component response regulators%2C e.g. TR:CAB51249 (EMBL:AL096872) Streptomyces coelicolor two-component response regulator SC5F7.36c%2C 227 aa%3B fasta scores: opt: 752 z-score: 883.6 E(): 0%3B 57.7%25 identity in 220 aa overlap. Contains two Pfam matches to entries PF00072 response_reg and PF00196 GerE. Contains also a possible helix-turn-helix motif at residues 168..189 (+3.69 SD) gene gene2522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2517 SCO2518 SCO2518 SCC121.21c SCC121.21c 2713432 2714775 - two-component sensor kinase SCC121.21c%2C possible two-component sensor kinase%2C len: 447 aa%3B similar to various S. coelicolor two-component sensor kinases%2C e.g. TR:CAB51250 (EMBL:AL096872) Streptomyces coelicolor two-component sensor kinase SC5F7.35c%2C 416 aa%3B fasta scores: opt: 752 z-score: 802.9 E(): 0%3B 40.7%25 identity in 410 aa overlap gene gene2523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2518 SCO2519 SCO2519 SCC121.22c SCC121.22c 2714777 2716855 - hypothetical protein SCC121.22c%2C probable membrane protein%2C len: 692 aa%3B similar to SW:MMLA_STRCO (EMBL:M64683) Streptomyces coelicolor membrane protein ActII-3%2C 711 aa%3B fasta scores: opt: 1700 z-score: 1790.7 E(): 0%3B 42.7%25 identity in 693 aa overlap and to S. coelicolor SCF43.29c%2C 705 aa%3B fasta scores: opt: 848 z-score: 750.5 E(): 0%3B 40.1%25 identity in 700 aa overlap gene gene2524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2519 SCO2520 SCO2520 SCC121.23c SCC121.23c 2717003 2718136 - hypothetical protein SCC121.23c%2C possible membrane protein%2C len: 377 aa. Contains possible hydrophobic membrane spanning regions gene gene2525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2520 SCO2521 SCO2521 SCC121.24c SCC121.24c 2718235 2719215 - hypothetical protein SCC121.24c%2C unknown%2C len: 326 aa gene gene2526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2521 SCO2522 SCO2522 SCC121.25c SCC121.25c 2719217 2720170 - hypothetical protein SCC121.25c%2C unknown%2C len: 317 aa gene gene2527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2522 SCO2523 SCO2523 SCC121.26c SCC121.26c 2720179 2721096 - hypothetical protein SCC121.26c%2C unknown%2C len: 305 aa gene gene2528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2523 SCO2524 SCO2524 SCC121.27c SCC121.27c 2721099 2722943 - hypothetical protein SCC121.27c%2C unknown%2C len: 614 aa gene gene2529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2524 SCO2525 SCO2525 SCC121.28c SCC121.28c 2723027 2723800 - hypothetical protein SCC121.28c%2C unknown%2C len: 257 aa gene gene2530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2525 SCO2526 SCO2526 SCC121.29 SCC121.29 2724049 2724603 + acetyltransferase SCC121.29c%2C possible acetyltransferase%2C len: 184 aa%3B similar to TR:O27080 (EMBLAE000872:) Methanobacterium thermoautotrophicum N-terminal acetyltransferase complex%2C subunit Ard1 MTH999%2C 156 aa%3B fasta scores: opt: 232 z-score: 289.3 E(): 1e-08%3B 29.6%25 identity in 152 aa overlap and to TR:CAB50578 (EMBL:AJ248288) Pyrococcus abyssi N-terminal acetyltransferase%2C 172 aa%3B fasta scores: opt: 213 z-score: 266.0 E(): 2e-07%3B 30.3%25 identity in 142 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf gene gene2531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2526 SCO2527 SCO2527 SCC121.30c SCC121.30c 2724600 2725295 - hypothetical protein SCC121.30c%2C unknown%2C len: 231 aa gene gene2532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2527 SCO2528 SCO2528 leuA leuA 2725480 2727201 - 2-isopropylmalate synthase SCC121.31c%2C leuA%2C 2-ispoprylmalate synthase (EC 4.1.3.12)%2C len: 499 aa%3B identical to C-terminal region of previously sequenced Streptomyces coelicolor 2-isopropylmalate synthase (EC 4.1.3.12) LeuA%2C 573 aa and highly similar to SW:LEU1_CORGL (EMBL:X70959) Corynebacterium glutamicum (Brevibacterium flavum) 2-isopropylmalate synthase (EC 4.1.3.12) (alpha-isopropylmalate synthase) (alpha-ipm synthetase) LeuA%2C 616 aa%3B fasta scores: opt: 1812 z-score: 2105.1 E(): 0%3B 55.1%25 identity in 506 aa overlap. Contains Pfam match to entry PF00682 HMGL-like and match to Prosite entry PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2~SCC117.01c%2C leuA%2C 2-isopropylmalate synthase (EC 4.1.3.12) (fragment)%2C len: > 113 aa. Previously sequenced and characterised Streptomyces coelicolor TR:O31046(EMBL:AF026444) (573 aa). Contains a Prosite hit to PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. Overlaps and extends into CDS SCC121.31c on the adjoining cosmid. gene gene2533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2528 SCO2529 SCO2529 SCC117.02 SCC117.02 2727564 2728634 + metalloprotease SCC117.02%2C possible metalloprotease%2C len: 356 aa. Highly similar to several including: Serratia marcescens SW:SMP_SERMA(EMBL:M59854) extracellular minor metalloprotease precursor (EC 3.4.24.-) (352 aa)%2C fasta scores opt: 659 z-score: 721.0 E(): 9e-33 41.2%25 identity in 291 aa overlap and Erwinia carotovora subsp. carotovora SW:PRT1_ERWCA(EMBL:M36651) extracellular metalloprotease precursor (EC 3.4.24.-) (347 aa)%2C fasta scores opt: 1151 z-score: 1254.0 E():0 49.6%25 identity in 349 aa overlap. Contains a Pfam match to entry PF01447 Peptidase_M4%2C Thermolysin family peptidase and a Prosite hit to S00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. gene gene2534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2529 SCO2530 SCO2530 SCC117.03 SCC117.03 2728656 2728922 + hypothetical protein SCC117.03%2C unknown%2C len: 88 aa. gene gene2535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2530 SCO2531 SCO2531 SCC117.04 SCC117.04 2728980 2730326 + beta-glucosidase SCC117.04%2C possible beta-glucosidase%2C len: 448 aa. Highly similar to many including: Microbispora bispora SW:BGLB_MICBI(EMBL:M97265) thermostable beta-glucosidase B (EC 3.2.1.21) (473 aa)%2C fasta scores opt: 1059 z-score: 1221.1 E(): 0 48.7%25 identity in 454 aa overlap and Paenibacillus polymyxa (Bacillus polymyxa) SW:BGLA_PAEPO(EMBL:M60210) beta-glucosidase A (EC 3.2.1.21) (448 aa)%2C fasta scores opt: 1014 z-score: 1169.7 E():0 40.4%25 identity in 455 aa overlap. Contains a Prosite hit to PS00653 Glycosyl hydrolases family 1 N-terminal signature and a Pfam match to entry PF00232 Glyco_hydro_1%2C Glycosyl hydrolase family 1. gene gene2536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2531 SCO2532 SCO2532 SCC117.05 SCC117.05 2730432 2731511 + PhoH-like protein SCC117.05%2C PhoH-like protein%2C len: 359 aa. Highly similar to many including: Escherichia coli SW:PHOH_ECOLI (EMBL:D10391) phosphate starvation-inducible protein PhoH protein (354 aa)%2C fasta scores opt: 583 z-score: 650.4 E(): 7.8e-29 37.7%25 identity in 321 aa overlap and Mycobacterium tuberculosis SW:PHOL_MYCTU(EMBL:Z95208) PhoH-like protein (352 aa)%2C fasta scores opt: 1407 z-score: 1560.0 E():0 63.6%25 identity in 349 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene2537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2532 SCO2533 SCO2533 SCC117.06 SCC117.06 2731524 2732021 + metalloprotease SCC117.06%2C unknown%2C len: 165 aa. Highly similar to several proteins of unknown function%2C including: Mycobacterium tuberculosis SW:Y1DD_MYCTU(EMBL:Z95208) hypothetical 20.3 KD protein (182 aa)%2C fasta scores opt: 599 z-score: 713.5 E(): 2.4e-32 56.5%25 identity in 154 aa overlap and Mycobacterium leprae SW:YN67_MYCLE(EMBL:U00016) hypothetical 19.8 KD protein (178 aa)%2C fasta scores opt: 588 z-score: 700.8 E(): 1.2e-31 54.5%25 identity in 154 aa overlap. Contains a Prosite hit to PS01306 Uncharacterised protein family UPF0054 signature gene gene2538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2533 SCO2534 SCO2534 SCC117.07 SCC117.07 2732018 2733322 + hypothetical protein SCC77.01%2C unknown%2C partial CDS%2C len: > 110 aa. Highly similar to a protein of undefined function from Mycobacterium tuberculosis SW:Y1DE_MYCTU(EMBL:Z95208) (435 aa)%2C fasta scores opt: 290 z-score: 369.6 E(): 3.4e-13 54.0%25 identity in 100 aa overlap. Overlaps and extends into CDS SCC117.07 on the adjoining cosmid.~SCC117.07%2C possible membrane protein%2C partial CDS%2C len: > 358 aa. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis SW:YN66_MYCTU(EMBL:Z95208) hypothetical 47.2 KD protein (435 aa)%2C fasta scores opt: 1159 z-score: 1367.6 E(): 0 53.0%25 identity in 353 aa overlap and Thermotoga maritima TR:Q9WZU9(EMBL:AE001751) hemolysin-related protein (455 aa)%2C fasta scores opt: 568 z-score: 671.7 E(): 5.1e-30 29.9%25 identity in 355 aa overlap. Contains a Pfam match to entry PF01595 DUF21%2C Domain of unknown function and 2xPfam matches to entry PF00571 CBS%2C CBS domain. Contains a possible N-terminal signal sequence and membrane spanning hydrophobic domains. Overlaps and extends into CDS SCC77.01 on the adjoining cosmid. gene gene2539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2534 SCO2535 SCO2535 SCC77.02 SCC77.02 2733319 2733693 + hypothetical protein SCC77.02%2C unknown%2C len: 124 aa. Similar to several proteins of unknown function including: Streptomyces lavendulae TR:Q9X5T5(EMBL:AF127374) MmcQ%2C located within the antibiotic mitomycin C biosynthetic gene cluster (123 aa)%2C fasta scores opt: 377 z-score: 487.1 E(): 9.6e-20 52.0%25 identity in 127 aa overlap and Deinococcus radiodurans TR:AAF11947(EMBL:AE002071) conserved hypothetical protein (132 aa)%2C fasta scores opt: 299 z-score: 389.0 E(): 2.8e-14 43.0%25 identity in 128 aa overlap. gene gene2540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2535 SCO2536 SCO2536 SCC77.03c SCC77.03c 2733655 2735154 - transmembrane transport protein SCC77.03c%2C probable transmembrane transport protein%2C len: 499 aa. Highly similar to many including: Nocardia lactamdurans SW:CMCT_NOCLA(EMBL:Z13973) cephamycin export protein CmcT (486 aa)%2C fasta scores opt: 721 z-score: 808.4 E():0 38.5%25 identity in 478 aa overlap and Streptomyces coelicolor TR:O54179(EMBL:AL021411) export protein SC7H1.20C (483 aa)%2C fasta scores opt: 745 z-score: 835.2 E():0 47.1%25 identity in 495 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr and multiple possible membrane spanning hydrophobic domains. gene gene2541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2536 SCO2537 SCO2537 SCC77.04c SCC77.04c 2735261 2736145 + DNA-binding protein SCC77.04c%2C possible DNA-binding protein%2C len: 294 aa. Highly similar to several other Streptomyces coelicolor proteins including: TR:CAB52924 (EMBL:AL109949) DNA-binding protein SCJ11.39C (279 aa)%2C fasta scores opt: 575 z-score: 702.8 E(): 9.3e-32 41.2%25 identity in 257 aa overlap and TR:CAB55664 (EMBL:AL117385) hypothetical 32.2 KD protein SC5G9.16 (295 aa)%2C fasta scores opt: 521 z-score: 637.0 E(): 4.3e-28 36.5%25 identity in 288 aa overlap. Contains a helix-turn-helix motif situated between residues 47..68 (+2.88 SD). gene gene2542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2537 SCO2538 SCO2538 SCC77.05 SCC77.05 2736142 2736540 + hypothetical protein SCC77.05%2C unknown%2C len: 132 aa. Similar to Mycobacterium tuberculosis TR:O05833(EMBL:Z95208) hypothetical 11.1 KD protein (113 aa)%2C fasta scores opt: 254 z-score: 298.3 E(): 3.2e-09 53.1%25 identity in 96 aa overlap and Mycobacterium leprae TR:Q49767(EMBL:U00016) hypothetical 11.1 KD protein (108 aa)%2C fasta scores opt: 186 z-score: 224.0 E(): 4.4e-05 39.4%25 identity in 99 aa overlap. gene gene2543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2538 SCO2539 SCO2539 era era 2736597 2737559 + GTP-binding protein Era Era%3B Escherichia coli Ras-like protein%3B Bex%3B Bacillus Era-complementing segment%3B essential protein in Escherichia coli that is involved in many cellular processes%3B GTPase%3B binds the cell membrane through apparent C-terminal domain%3B mutants are arrested during the cell cycle%3B Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome gene gene2544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2539 SCO2540 SCO2540 SCC77.07c SCC77.07c 2737582 2738772 - carbohydrate kinase SCC77.07c%2C possible carbohydrate kinase%2C len: 396 aa. Weakly similar to many kinases including: Escherichia coli SW:RBSK_ECOLI(EMBL:M13169) ribokinase (EC 2.7.1.15) (309 aa)%2C fasta scores opt: 283 z-score: 306.1 E(): 1.2e-09 29.3%25 identity in 297 aa overlap. Contains a Prosite hit to PS00584 pfkB family of carbohydrate kinases signature 2 and a Pfam match to entry PF00294 pfkB. Rich in the amino acid Ala. gene gene2545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2540 SCO2541 SCO2541 SCC77.08c SCC77.08c 2738852 2740222 - transmembrane transport protein SCC77.08c%2C probable transmembrane transport protein%2C len: 456 aa. Highly similar to many including: Pseudomonas putida SW:PHT1_PSEPU(EMBL:D13229) phthalate transporter (451 aa)%2C fasta scores opt: 817 z-score: 912.4 E():0 34.6%25 identity in 416 aa overlap%2C Streptomyces coelicolor TR:CAB61275(EMBL:AL132991) transporter SCF55.05C (455 aa)%2C fasta scores opt: 699 z-score: 781.2 E():0 36.0%25 identity in 453 aa overlap and Agrobacterium vitis SW:TUB4_AGRVI(EMBL:U25634) tartrate transporter (433 aa)%2C fasta scores opt: 1154 z-score: 1287.3 E():0 43.6%25 identity in 433 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr and multiple possible membrane spanning hydrophobic domains. gene gene2546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2541 SCO2542 SCO2542 SCC77.09c SCC77.09c 2740287 2741582 - glucarate dehydratase SCC77.09c%2C possible glucarate dehydratase%2C len: 431 aa. Similar to many glucarate dehydratases and (less similar) to many members of the mandelate racemase / muconate lactonizing enzyme family: Escherichia coli SW:GUD1_ECOLI(EMBL:AE000362) probable glucarate dehydratase 1 (EC 4.2.1.40) (446 aa)%2C fasta scores opt: 673 z-score: 769.9 E(): 0 37.3%25 identity in 440 aa overlap and Rhodococcus opacus TR:O67985(EMBL:AF003948) chloromuconate cycloisomerase (373 aa)%2C fasta scores opt: 271 z-score: 312.8 E(): 4.9e-10 26.2%25 identity in 416 aa overlap. Contains a Pfam match to entry PF01188 MR_MLE. gene gene2547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2542 SCO2543 SCO2543 SCC77.10c SCC77.10c 2741579 2742547 - 5-dehydro-4-deoxyglucarate dehydratase catalyzes the formation of 2%2C5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate gene gene2548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2543 SCO2544 SCO2544 SCC77.11 SCC77.11 2742662 2743459 + IclR family transcriptional regulator SCC77.11%2C possible IclR-family transcriptional regulator%2C len: 265 aa. Similar to many other IclR-family regulators including: Escherichia coli SW:ICLR_ECOLI (EMBL:M31761) acetate operon repressor IclR (274 aa)%2C fasta scores opt: 368 z-score: 447.5 E(): 1.5e-17 33.1%25 identity in 263 aa overlap and Erwinia carotovora subsp. carotovora TR:AAD50647 (EMBL:AF135396) regulator of virulence KdgR (263 aa)%2C fasta scores opt: 326 z-score: 397.5 E(): 9.4e-15 29.7%25 identity in 239 aa overlap. Contains a possible N-terminal helix-turn-helix motif%2C situated between residues 36..57 (+4.94 SD) and a Pfam match to entry PF01614 IclR. gene gene2549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2544 SCO2545 SCO2545 SCC77.12 SCC77.12 2743633 2744982 + transmembrane efflux protein SCC77.12%2C possible transmembrane efflux protein%2C len: 449 aa. Weakly similar to Streptomyces lividans SW:CMLR_STRLI(EMBL:X59968) chloramphenicol resistance protein CmlR (392 aa)%2C fasta scores opt: 234 z-score: 234.3 E(): 1.2e-05 27.5%25 identity in 396 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene2550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2545 SCO2546 SCO2546 SCC77.13c SCC77.13c 2745002 2746024 - adenosine deaminase catalyzes the formation of inosine from adenosine gene gene2551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2546 SCO2547 SCO2547 SCC77.14c SCC77.14c 2746021 2746926 - ribonuclease Z member of metallo-beta-lactamase family%3B the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase%3B in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not%3B associates with two zinc ions gene gene2552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2547 SCO2548 SCO2548 SCC77.15c SCC77.15c 2746955 2747308 - Hit-family protein SCC77.15c%2C possible Hit-family protein%2C len: 117 aa. Similar to many proteins carrying the HIT (histidine triad) family motif which is thought to mediate nucleotide binding%2C including: Oryctolagus cuniculus (Rabbit) SW:IPK1_RABIT(EMBL:Y11175) HinT protein (protein kinase C inhibitor 1) (125 aa)%2C fasta scores opt: 338 z-score: 429.0 E(): 1.7e-16 47.4%25 identity in 114 aa overlap and Aquifex aeolicus SW:YHIT_AQUAE(EMBL:AE000675) hypothetical Hit-like protein AQ_141 (121 aa)%2C fasta scores opt: 369 z-score: 467.0 E(): 1.3e-18 46.2%25 identity in 119 aa overlap. Contains a Pfam match to entry PF01230 HIT. gene gene2553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2548 SCO2549 SCO2549 SCC77.16c. SCC77.16c. 2747664 2750867 - protease SCC77.16c%2C possible protease%2C len: 1067 aa. Similar to Thermoplasma acidophilum TR:P96086(EMBL:U72850) tricorn protease (1071 aa)%2C fasta scores opt:opt: 937 z-score: 985.8 E():0 29.9%25 identity in 1091 aa overlap and Streptomyces coelicolor TR:CAB59664(EMBL:AL132674) protease SCE87.19 (1171 aa)%2C fasta scores opt: 2252 z-score: 2374.0 E():0 48.1%25 identity in 1159 aa overlap. gene gene2554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2549 SCO2550 SCO2550 SCC77.17c SCC77.17c 2750935 2751450 - lipoprotein SCC77.17c%2C possible lipoprotein%2C len: 171 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene2555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2550 SCO2551 SCO2551 SCC77.18 SCC77.18 2751556 2751900 + hypothetical protein SCC77.18%2C unknown%2C len: 114 aa. gene gene2556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2551 SCO2552 SCO2552 sdrD sdrD 2751941 2752690 - 16S rRNA (uracil(1498)-N(3))-methyltransferase in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA%3B cells lacking this function can grow%2C but are outcompeted by wild-type%3B SAM-dependent m(3)U1498 methyltransferase gene gene2557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2552 SCO2553 SCO2553 SCC77.20c SCC77.20c 2752687 2753781 - oxidoreductase SCC77.20c%2C possible oxidoreductase%2C len: 364 aa. This CDS has been partially sequenced and the C-terminal 142 aa%2C of its predicted protein product%2C are identical to Streptomyces coelicolor TR:Q02797(EMBL:X68792) hypothetical protein in pth270 promoter (fragment). Also highly similar to Mycobacterium tuberculosis TR:O33323(EMBL:AL008967) oxidoreductase (344 aa)%2C fasta scores opt: 912 z-score: 971.6 E(): 0 45.5%25 identity in 336 aa overlap and Bacillus subtilis TR:O05413(EMBL:U93875) 2-nitropropane dioxygenase (347 aa)%2C fasta scores opt: 702 z-score:749.8 E(): 0 37.8%25 identity in 339 aa overlap. gene gene2558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2553 SCO2554 SCO2554 dnaJ2 dnaJ2 2753870 2755006 - chaperone protein DnaJ chaperone Hsp40%3B co-chaperone with DnaK%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C dnaK-independent fashion gene gene2559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2554 SCO2555 SCO2555 hrcA hrcA 2755007 2756023 - heat-inducible transcription repressor Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons gene gene2560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2555 SCO2556 SCO2556 SCC77.23 SCC77.23 2756208 2756951 + hypothetical protein SCC77.23%2C unknown%2C len: 247 aa. Similar to Mycobacterium tuberculosis TR:O07720(EMBL:Z97193) hypothetical 26.9 KD protein (250 aa)%2C fasta scores opt: 618 z-score: 666.7 E(): 9.6e-30 45.0%25 identity in 238 aa overlap gene gene2561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2556 SCO2557 SCO2557 SCC77.24 SCC77.24 2756986 2757810 + hypothetical protein SCC77.24%2C unknown%2C len: 274 aa. Similar to Mycobacterium tuberculosis TR:O53477(EMBL:AL021899) hypothetical 30.5 KD protein (280 aa)%2C fasta scores opt: 1044 z-score: 1136.4 E(): 0 61.9%25 identity in 268 aa overlap. gene gene2562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2557 SCO2558 SCO2558 SCC77.25c SCC77.25c 2757788 2758462 - hypothetical protein SCC77.25c%2C unknown%2C len: 224 aa. gene gene2563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2558 SCO2559 SCO2559 SCC77.26c SCC77.26c 2758482 2759789 - coproporphyrinogen III oxidase catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III gene gene2564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2559 SCO2560 SCO2560 SCC77.27c SCC77.27c 2759799 2762177 - hypothetical protein SCC77.27c%2C unknown%2C len: 792 aa. Weakly similar to Streptomyces coelicolor TR:O86807 (EMBL:AL031031) regulatory protein SC7C7.02C (916 aa)%2C fasta scores opt: 447 z-score: 376.3 E(): 1.4e-13 34.1%25 identity in 954 aa overlap. The N-terminus is also similar Streptomyces coelicolor TR:Q53897(EMBL:X60316) OrfA within the AbaA pleiotropic regulatory locus for antibiotic production (192 aa)%2C fasta scores opt: 248 z-score: 220.6 E(): 6.7e-05 37.1%25 identity in 178 aa overlap gene gene2565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2560 SCO2561 SCO2561 SCC77.28c SCC77.28c 2762403 2764346 - long-chain fatty-acid CoA ligase SCC77.28c%2C possible long-chain fatty-acid CoA ligase%2C len: 647 aa. Similar to many from eukaryotes and prokaryotes including: Homo sapiens (Human) SW:LCFB_HUMAN(EMBL:D10040) long-chain-fatty-acid-CoA ligase 2 (EC 6.2.1.3) (698 aa)%2C fasta scores opt: 698 z-score: 755.0 E(): 0 29.6%25 identity in 612 aa overlap and Streptomyces coelicolor TR:Q9X7Z0(EMBL:AL049497) long chain fatty acid CoA ligase SC6G10.04 (598 aa)%2C fasta scores opt: 1056 z-score: 1142.9 E():0 40.5%25 identity in 583 aa overlap. Contains a Pfam match to entry PF00501 AMP-binding and a Prosite hit to PS00455 AMP-binding domain signature. gene gene2566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2561 SCO2562 SCO2562 lepA lepA 2764588 2766456 - GTP-binding protein LepA binds to the ribosome on the universally-conserved alpha-sarcin loop gene gene2567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2562 SCO2563 SCO2563 rpsT rpsT 2766694 2766960 + 30S ribosomal protein S20 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase gene gene2568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2563 SCO2564 SCO2564 SCC123.02c SCC123.02c 2767268 2768278 - DNA-binding protein SCC123.02c%2C possible DNA-binding protein%2C len: 336 aa. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:P71730 (EMBL:Z81368) hypothetical 33.1 KD protein (316 aa)%2C fasta scores opt: 792 z-score: 880.3 E():0 42.4%25 identity in 316 aa overlap. Note that codon 21 may be an alternative translational start site. Contains a possible helix-turn-helix motif situated between residues 263..284 (+2.96 SD) gene gene2569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2564 SCO2565 SCO2565 SCC123.03c SCC123.03c 2768323 2768544 - hypothetical protein SCC123.03c%2C unknown%2C len: 73 aa. gene gene2570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2565 SCO2566 SCO2566 SCC123.04c SCC123.04c 2768600 2769481 - hypothetical protein SCC123.04c%2C hypothetical protein%2C len: 293 aa. Similar in parts to several proteins of unknown function e.g. Streptomyces coelicolor TR:O86515(EMBL:AL031124) hypothetical 20.0 KD protein (185 aa)%2C fasta scores: opt: 384 z-score: 456.7 E(): 4.7e-18 32.8%25 identity in 180 aa overlap gene gene2571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2566 SCO2567 SCO2567 SCC123.05c SCC123.05c 2769878 2772445 - hypothetical protein SCC123.05c%2C possible integral membrane protein%2C len: 855 aa. Similar to Bacillus subtilis SW:CME3_BACSU(EMBL:L15202) ComE operon protein 3%2C required for the binding and uptake of transforming DNA (776 aa)%2C fasta scores opt: 355 z-score: 368.7 E(): 3.8e-13 26.3%25 identity in 635 aa overlap and Mycobacterium tuberculosis TR:P71729(EMBL:Z81368) hypothetical 52.8 KD protein (514 aa)%2C fasta scores opt: 450 z-score: 470.1 E(): 8.5e-19 35.2%25 identity in 546 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene2572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2567 SCO2568 SCO2568 SCC123.06c SCC123.06c 2772442 2773509 - DNA-binding protein SCC123.06c%2C possible DNA-binding protein%2C len: 355 aa. Similar to Mycobacterium tuberculosis TR:P71728 (EMBL:Z81368) hypothetical 30.5 KD protein (297 aa)%2C opt: 271 z-score: 260.6 E(): 4e-07 36.3%25 identity in 292 aa overlap. Also similar in parts to Bacillus subtilis SW:CME1_BACSU (EMBL:L15202) ComE operon protein 1%2C required for the binding and uptake of transforming DNA (205 aa)%2C fasta scores opt: 295 z-score: 284.5 E(): 1.9e-08 32.2%25 identity in 180 aa overlap. Contains a Pfam match to entry PF00633 HHH%2C Helix-hairpin-helix motif and a possible membrane spanning hydrophobic domain. gene gene2573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2568 SCO2569 SCO2569 SCC123.07c SCC123.07c 2773654 2774499 - hypothetical protein SCC123.07c%2C unknown%2C len: 281 aa. Similar to several proteins of undefined function including: Bacillus subtilis SW:DEGV_BACSU(EMBL:Z18629) DegV protein (281 aa)%2C fasta scores opt: 549 z-score: 626.7 E(): 1.6e-27 37.1%25 identity in 278 aa overlap and Mycobacterium tuberculosis TR:P71726 (EMBL:Z81368) hypothetical 28.5 KD protein (280 aa)%2C fasta scores opt: 579 z-score: 660.5 E(): 2.1e-29 38.3%25 identity in 274 aa overlap gene gene2574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2569 SCO2570 SCO2570 SCC123.08c SCC123.08c 2774591 2775367 - hypothetical protein SCC123.08c%2C possible hypothetical protein%2C len: 258 aa. Contains a possible N-terminal signal sequence. gene gene2575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2570 SCO2571 SCO2571 leuS leuS 2775536 2778436 - leucyl-tRNA synthetase leucine--tRNA ligase%3B LeuRS%3B class-I aminoacyl-tRNA synthetase%3B charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA%3B due to the large number of codons that tRNA(Leu) recognizes%2C the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA%2C but instead recognition is dependent on a conserved discriminator base A37 and a long arm%3B an editing domain hydrolyzes misformed products%3B in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase gene gene2576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2571 SCO2572 SCO2572 SCC123.10 SCC123.10 2778973 2780259 + hypothetical protein SCC123.10%2C possible integral membrane protein%2C len: 428 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene2577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2572 SCO2573 SCO2573 SCC123.11 SCC123.11 2780292 2781866 + oxidoreductase SCC123.11%2C possible oxidoreductase%2C len: 524 aa. Weakly similar to several including: Homo sapiens (Human) SW:NUBM_HUMAN(EMBL:Y17379) NADH-ubiquinone oxidoreductase 51 KD subunit precursor (EC 1.6.5.3) (464 aa)%2C fasta scores opt: 341 z-score: 369.2 E(): 3.6e-13 27.1%25 identity in 365 aa overlap and Streptomyces coelicolor TR:Q9XAQ9(EMBL:AL078618) NADH dehydrogenase subunit%2C NuoF (449 aa)%2C fasta scores opt: 398 z-score: 430.5 E(): 1.4e-16 26.5%25 identity in 392 aa overlap. gene gene2578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2573 SCO2574 SCO2574 SCC123.12c SCC123.12c 2782151 2782384 - hypothetical protein SCC123.12c%2C doubtful CDS%2C len: 77 aa. gene gene2580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2574 SCO2575 SCO2575 SCC123.13c SCC123.13c 2782388 2782615 - hypothetical protein SCC123.13c%2C doubtful CDS%2C len: 75 aa. gene gene2581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2575 SCO2576 SCO2576 pgm2 pgm2 2782944 2783615 - phosphoglycerate mutase SCC123.14c%2C pgm2%2C phosphoglycerate mutase%2C len: 223 aa. Highly similar to several other phosphoglycerate mutases including: Escherichia coli SW:PMG2_ECOLI (EMBL:M97495) GpmB (215 aa)%2C fasta scores opt: 252 z-score: 313.8 E(): 4.4e-10 32.5%25 identity in 194 aa overlap and Deinococcus radiodurans TR:AAF10667(EMBL:AE001959) (232 aa)%2C fasta scores opt: 317 z-score: 392.0 E(): 1.9e-14 41.5%25 identity in 193 aa overlap. Contains a Prosite hit to PS00175 Phosphoglycerate mutase family phosphohistidine signature and a Pfam match to entry PF00300 PGAM%2C Phosphoglycerate mutase family. gene gene2583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2576 SCO2577 SCO2577 SCC123.15c SCC123.15c 2783612 2784058 - hypothetical protein SCC123.15c%2C unknown%2C len: 148 aa. Highly similar to several proteins of undefined function including: Bacillus subtilis SW:YQEL_BACSU(EMBL:D84432) YqeL (118 aa)%2C fasta scores opt: 286 z-score: 365.1 E(): 6e-13 42.6%25 identity in 108 aa overlap and Mycobacterium tuberculosis TR:O86327(EMBL:Z81368) (126 aa)%2C fasta scores opt: 441 z-score: 553.8 E(): 1.9e-23 51.9%25 identity in 129 aa overlap gene gene2584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2577 SCO2578 SCO2578 SCC123.16c SCC123.16c 2784151 2785929 - hypothetical protein SCC123.16c%2C possible membrane protein%2C len: 592 aa. Contains a possible membrane spanning hydrophobic domain. The protein is rich in the amino acid Gln and has a notable repeat region with 6x QQ(G/Y) between residues 53..84. gene gene2585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2578 SCO2579 SCO2579 nadD nadD 2785946 2786662 - nicotinic acid mononucleotide adenylyltransferase transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase%3B essential enzyme in bacteria gene gene2586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2579 SCO2580 SCO2580 SCC123.18c SCC123.18c 2786722 2786889 - hypothetical protein SCC123.18c%2C possible membrane protein%2C len: 55 aa. Contains a possible membrane spanning hydrophobic domain. gene gene2587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2580 SCO2581 SCO2581 SCC123.19c SCC123.19c 2786987 2787181 - hypothetical protein SCC123.19c%2C possible membrane protein%2C len: 64 aa. Contains a possible membrane spanning hydrophobic domain. gene gene2588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2581 SCO2582 SCO2582 SCC123.20 SCC123.20 2787290 2788498 + hypothetical protein SCC123.20%2C unknown%2C len: 402 aa. Similar to Mycobacterium tuberculosis TR:O53978(EMBL:AL022073) hypothetical 38.3 KD protein (348 aa)%2C fasta scores opt: 1044 z-score: 981.9 E():0 49.5%25 identity in 319 aa overlap and Synechocystis sp. (strain PCC 6803) TR:P73529(EMBL:D90907) hypothetical 34.0 KD protein (303 aa)%2C fasta scores opt: 568 z-score: 540.3 E(): 1.1e-22 37.5%25 identity in 269 aa overlap. gene gene2589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2582 SCO2583 SCO2583 SCC123.21c SCC123.21c 2788512 2789582 - hypothetical protein SCC123.21c%2C possible membrane protein%2C len: 356 aa. similar to TR:Q9L0J6 (EMBL:AL161691) SCD40A.15 membrane protein from Streptomyces coelicolor (379 aa) fasta scores%3B opt: 350%2C Z-score: 385.8%2C E(): 7.4e-14%2C 30.056%25 identity (33.025%25 ungapped) in 356 aa overlap. Contains a possible membrane spanning hydrophobic domain. gene gene2590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2583 SCO2584 SCO2584 SCC123.22c SCC123.22c 2789669 2790355 - hypothetical protein SCC123.22c%2C possible membrane protein%2C len: 228 aa. Contains a possible membrane spanning hydrophobic domain. gene gene2591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2584 SCO2585 SCO2585 proA proA 2790362 2791648 - gamma-glutamyl phosphate reductase Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway gene gene2592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2585 SCO2586 SCO2586 SCC123.24c SCC123.24c 2791720 2792250 - hypothetical protein SCC123.24c%2C unknown%2C len: 176 aa. gene gene2593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2586 SCO2587 SCO2587 proB proB 2792386 2793510 - gamma-glutamyl kinase catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis gene gene2594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2587 SCO2588 SCO2588 SCC123.26 SCC123.26 2794753 2796912 + hypothetical protein SCC123.26%2C possible integral membrane protein%2C len: 719 aa. Contains possible membrane spanning hydrophobic domains. gene gene2595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2588 SCO2589 SCO2589 SCC123.27 SCC123.27 2797141 2799372 + glycosyl transferase SCC123.27%2C possible glycosyl transferase%2C len: 743 aa. Weakly similar to Staphylococcus epidermidis TR:AAD56434(EMBL:AF162863) poly(glycerolphosphate) glycerophosphotransferase%2C TagF (721 aa)%2C fasta scores opt: 564 z-score: 661.8 E(): 1.8e-29 27.4%25 identity in 731 aa overlap and Bacillus subtilis SW:TAGF_BACSU(EMBL:X15200) teichoic acid biosynthesis protein%2C TagF (746 aa)%2C fasta scores opt: 567 z-score: 665.1 E(): 1.2e-29 30.9%25 identity in 417 aa overlap. Also similar to the adjoining gene fragment%2C CDS SCC123.28 (> 97 aa)%2C fasta scores opt: 298 z-score: 353.4 E(): 2.9e-14 47.9%25 identity in 96 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene2596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2589 SCO2590 SCO2590 SCC123.28 SCC123.28 2799396 2802989 + glycosyltransferase SCC88.01 possible glycosyltransferase%2C len: >1135 aa%3B N-terminal region similar to TR:Q9XC92 (EMBL:AF146532) Klebsiella pneumoniae glycosyltransferase%2C 329 aa%3B fasta scores: opt: 214 z-score: 245.4 E(): 3e-06%3B 21.3%25 identity in 263 aa overlap and C-terminal region similar to SW:TAGF_BACSU (EMBL:X15200) Bacillus subtilis teichoic acid biosynthesis protein F TagF%2C 746 aa%3B fasta scores: opt: 1056 z-score: 1203.0 E(): 0%3B 41.5%25 identity in 381 aa overlap~SCC123.28%2C possible glycosyl transferase%2C partial CDS%2C len: > 97 aa. Similar to several proteins associated with polysaccharide biosynthesis e.g. Lactococcus lactis TR:O06035(EMBL:AF036485) galactosyltransferase%2C EpsG (316 aa)%2C fasta scores opt: 309 z-score: 414.0 E(): 1.1e-15 47.4%25 identity in 95 aa overlap and Streptococcus suis TR:Q9X4V4(EMBL:AF118389) glycosyltransferase%2C Cps2J (332 aa)%2C fasta scores opt: 309 z-score: 413.6 E(): 1.2e-15 46.8%25 identity in 94 aa overlap. Also similar to the adjoining CDS%2C SCC123.27 (743 aa)%2C fasta scores opt: 298 z-score: 353.4 E(): 2.9e-14 47.9%25 identity in 96 aa overlap. gene gene2597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2590 SCO2591 SCO2591 SCC88.02 SCC88.02 2803160 2804890 + hypothetical protein SCC88.02. possible hypothetical protein%2C len: 576 aa%3B similar to TR:CAB51964 (EMBL:AL109661) Streptomyces coelicolor hypothetical 100.7 kD protein SC6E10.10%2C 943 aa%3B fasta scores: opt: 522 z-score: 556.2 E(): 1.4e-23%3B 31.8%25 identity in 471 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2591 SCO2592 SCO2592 SCC88.03c SCC88.03c 2804967 2807795 - transferase SCC88.03c%2C possible transferase%2C len: 942 aa%3B N-terminal region similar to hypothetical proteins%2C e. g. TR:O69853 (EMBL:AL023702) Streptomyces coelicolor hypothetical 66.0 kD protein SC1C3.11%2C 586 aa%3B fasta scores: opt: 1214 z-score: 1395.6 E(): 0%3B 40.7%25 identity in 573 aa overlap and C-terminal region similar to TR:O69854 (EMBL:AL023702) Streptomyces coelicolor transferase SC1C3.12%2C 697 aa%3B fasta scores: opt: 658 z-score: 754.0 E(): 0%3B 30.1%25 identity in 574 aa overlap. Contains Pfam match at N-terminal region to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene2599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2592 SCO2593 SCO2593 SCC88.04c SCC88.04c 2807802 2808791 - hypothetical protein SCC88.04c%2C unknown%2C len: 329 aa gene gene2600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2593 SCO2594 SCO2594 SCC88.05c SCC88.05c 2808791 2810599 - hypothetical protein SCC88.05c%2C hypothetical protein%2C len: 586 aa%3B similar to various hypothetical proteins%2C e.g. TR:O69853 (EMBL:AL023702) Streptomyces coelicolor hypothetical 66.0 kD protein SC1C3.11%2C 586 aa%3B fasta scores: opt: 1251 z-score: 1446.9 E(): 0%3B 46.5%25 identity in 600 aa overlap gene gene2601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2594 SCO2595 SCO2595 obgE obgE 2810811 2812247 - GTPase ObgE essential GTPase%3B exhibits high exchange rate for GTP/GDP%3B associates with 50S ribosomal subunit%3B involved in regulation of chromosomal replication gene gene2602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2595 SCO2596 SCO2596 rpmA rpmA 2812358 2812612 - 50S ribosomal protein L27 involved in the peptidyltransferase reaction during translation gene gene2603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2596 SCO2597 SCO2597 rplU rplU 2812627 2812947 - 50S ribosomal protein L21 SCC88.08c%2C rplU%2C 50S ribosomal protein L21%2C len: 106 aa%3B identical to TR:P95756 (EMBL:D87916) Streptomyces griseus ribosomal protein L21 RplU%2C 106 aa and highly similar to SW:RL21_ECOLI (EMBL:D13267) Escherichia coli 50S ribosomal protein L21%2C RplU%2C 103 aa%3B fasta scores: opt: 272 z-score: 350.3 E(): 4.3e-12%3B 38.1%25 identity in 105 aa overlap. Contains Pfam match to entry PF00829 Ribosomal_L21p%2C Ribosomal prokaryotic L21 protein gene gene2604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2597 SCO2598 SCO2598 SCC88.09c SCC88.09c 2813146 2814168 - dehydrogenase SCC88.09c%2C probable dehydrogenase%2C len: 340 aa%3B highly similar to TR:Q9X7U9 (EMBL:AL049485) Streptomyces coelicolor glycerol dehydrogenase SC6A5.03%2C 340 aa%3B fasta scores: opt: 1734 z-score: 1970.7 E(): 0%3B 75.4%25 identity in 338 aa overlap and to SW:GLDA_PSEPU (EMBL:U08463) Pseudomonas putida glycerol dehydrogenase (EC 1.1.1.6) GldA%2C 365 aa%3B fasta scores: opt: 262 z-score: 302.6 E(): 1.9e-09%3B 25.7%25 identity in 335 aa overlap gene gene2605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2598 SCO2599 SCO2599 SCC88.10c SCC88.10c 2814360 2818382 - hypothetical protein SCC88.10c%2C hypothetical protein%2C len: 1340 aa%3B N-terminal region similar to TR:P71905 (EMBL:Z81451%3B) Mycobacterium tuberculosis hypothetical 103.4 kD protein%2C 953 aa%3B fasta scores: opt: 1098 z-score: 829.0 E(): 0%3B 48.7%25 identity in 881 aa overlap and C-terminal region similar to SW:CAFA_ECOLI (EMBL:X57166) Escherichia coli ribonuclease G%2C cytoplasmic axial filament protein CafA%2C 488 aa%3B fasta scores: opt: 996 z-score: 756.6 E(): 0%3B 39.0%25 identity in 405 aa overlap. Contains match to Prosite entry PS00107 Protein kinases ATP-binding region signature and possible coiled-coil region. Contains also two repeats: 10x(A/T)(T/A)KK and 4x(PEPAAA) gene gene2606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2599 SCO2600 SCO2600 SCC88.11c SCC88.11c 2818657 2819433 - hypothetical protein SCC88.11c%2C hypothetical protein%2C len: 258 aa%3B similar to TR:P73260 (EMBL:D90905) Synechocystis sp. hypothetical 97.4 kD protein%2C 865 aa%3B fasta scores: opt: 290 z-score: 317.3 E(): 2.9e-10%3B 31.3%25 identity in 179 aa overlap gene gene2607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2600 SCO2601 SCO2601 SCC88.12c SCC88.12c 2819482 2820558 - hypothetical protein SCC88.12c%2C possible integral membrane protein%2C len: 358 aa. Contain possible hydrophobic membrane spanning regions gene gene2608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2601 SCO2602 SCO2602 SCC88.13c SCC88.13c 2820608 2822731 - hypothetical protein SCC88.13c%2C unknown%2C len: 707 aa gene gene2609 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2602 SCO2603 SCO2603 SCC88.14 SCC88.14 2823656 2825212 + integrase SCC88.14%2C possible integrase%2C len: 518 aa%3B similar to TR:Q38184 (EMBL:X85213) Bacteriophage TP901-1 integrase%2C 485 aa%3B fasta scores: opt: 212 z-score: 243.5 E(): 3.8e-06%3B 24.2%25 identity in 417 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation gene gene2610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2603 SCO2604 SCO2604 SCC88.15c SCC88.15c 2825348 2826283 - hypothetical protein SCC88.15c%2C possible hypothetical protein%2C len: 311 aa. Contains N-terminal region signal peptide sequence and TTA leucine codon%2C possible target for bldA regulation gene gene2611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2604 SCO2605 SCO2605 SCC88.16 SCC88.16 2826447 2827148 + hypothetical protein SCC88.16%2C unknown%2C len: 233 aa gene gene2612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2605 SCO2606 SCO2606 orfsyn orfsyn 2827396 2829381 - hypothetical protein SCC88.17c%2C orfsyn%2C hypothetical protein%2C len: 661 aa%3B N-terminal region identical to previously sequenced TR:O33624 (EMBL:Y14206) Streptomyces coelicolor ORFSYN (fragment) and similar to TR:P73260 (EMBL:D90905) Synechocystis sp. hypothetical 97.4 kD protein 865 aa%3B fasta scores: opt: 1055 z-score: 1198.6 E(): 0%3B 41.2%25 identity in 624 aa overlap. Contains match to Prosite entry PS00133 Zinc carboxypeptidases%2C zinc-binding region 2 signature gene gene2613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2606 SCO2607 SCO2607 SCC88.18c SCC88.18c 2829460 2830656 - Sfr protein SCC88.18c%2C sfr%2C Sfr protein%2C len: 372 aa%3B identical to previously sequenced TR:O33623 (EMBL:Y14206) Streptomyces coelicolor Sfr protein and similar to SW:SP5E_BACSU (EMBL:X51419) Bacillus subtilis stage V sporulation protein E%2C SpoVE%2C 366 aa%3B fasta scores: opt: 795 z-score: 897.2 E(): 0%3B 39.4%25 identity in 363 aa overlap. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE%2C Cell cycle protein and match to Prosite entry PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. Contains also possible hydrophobic membrane spanning regions gene gene2614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2607 SCO2608 SCO2608 pbp2 pbp2 2830653 2832962 - penicillin binding protein SCC88.19c%2C pbp2%2C penicillin binding protein%2C len: 769 aa%3B almost identical to previously sequenced TR:O33622 (EMBL:Y14206) Streptomyces coelicolor Pbp protein and similar to SW:PBP2_ECOLI (EMBL:X04516) Escherichia coli penicillin-binding protein 2 (Pbp-2)%2C 633 aa%3B fasta scores: opt: 226 z-score: 236.5 E(): 9.3e-06%3B 27.9%25 identity in 692 aa overlap. Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain gene gene2615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2608 SCO2609 SCO2609 mreD mreD 2833015 2833686 - rod shape-determining protein SCC88.20c%2C mreD%2C rod shape-determining protein%2C len: 223 aa%3B identical to previously sequenced TR:O33621 (EMBL:Y14206) Streptomyces coelicolor MreD protein%2C 223 aa and similar to TR:O83512 (EMBL:AE001226) Treponema pallidum rod shape-determining protein (MreD)%2C 168 aa%3B fasta scores: opt: 135 z-score: 162.4 E(): 0.13%3B 24.8%25 identity in 161 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2609 SCO2610 SCO2610 mreC mreC 2833700 2834725 - rod shape-determining protein MreC in some organisms this protein is a transmembrane protein while in others it is periplasmic%3B involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall gene gene2617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2610 SCO2611 SCO2611 mreB mreB 2834908 2835939 - rod shape-determining protein MreB functions in MreBCD complex in some organisms gene gene2618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2611 SCO2612 SCO2612 ndk ndk 2836247 2836660 - nucleoside diphosphate kinase catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate gene gene2619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2612 SCO2613 SCO2613 SCC88.24c SCC88.24c 2836785 2837141 - hypothetical protein SCC88.24c%2C possible membrane protein%2C len: 117 aa%3B identical to previously sequenced TR:O06852 (EMBL:Y13070) Streptomyces coelicolor hypothetical 12.3 kD protein%2C 117 aa. Contains possible hydrophobic membrane spanning regions gene gene2620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2613 SCO2614 SCO2614 fpgS fpgS 2837148 2838482 - folylpolyglutamate synthase SCC88.25c%2C fpgS%2C folylpolyglutamate synthase%2C len: 444 aa%3B identical to previously sequenced TR:O08416 (EMBL:Y13070) Streptomyces coelicolor folylpolyglutamate synthase (EC 6.3.2.17)%2C 444 aa and similar to SW:FOLC_BACSU (EMBL:L04520) Bacillus subtilis folylpolyglutamate synthase (EC 6.3.2.17)%2C FolC%2C 430 aa%3B fasta scoreS: opt: 622 z-score: 688.7 E(): 6.1e-31%3B 32.0%25 identity in 438 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase%2C Mur ligase family and matches to Prosite entries PS00398 Site-specific recombinases signature 2 and PS01012 Folylpolyglutamate synthase signature 2 gene gene2621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2614 SCO2615 SCO2615 valS valS 2838957 2841581 - valyl-tRNA synthetase valine--tRNA ligase%3B ValRS%3B converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val)%3B class-I aminoacyl-tRNA synthetase type 1 subfamily%3B has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain gene gene2622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2615 SCO2616 SCO2616 SCC80.01 SCC80.01 2841719 2842726 + hypothetical protein SCC80.01%2C unknown (fragment)%2C len: >142 aa~SCC88.27%2C possible membrane protein%2C len: >225 aa. Rich in proline and glycine. Contains possible hydrophobic membrane spanning region and the following repeats at the N-terminal region: 4x(QPGPYG) and 4x(PPYGQQ) gene gene2623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2616 SCO2617 SCO2617 clpX clpX 2842798 2844084 - ATP-dependent protease ATP-binding subunit ClpX binds and unfolds substrates as part of the ClpXP protease gene gene2624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2617 SCO2618 SCO2618 clpP2 clpP2 2844276 2844986 - ATP-dependent Clp protease proteolytic subunit hydrolyzes proteins to small peptides%3B with the ATPase subunits ClpA or ClpX%2C ClpP degrades specific substrates gene gene2625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2618 SCO2619 SCO2619 clpP clpP 2845037 2845696 - ATP-dependent Clp protease proteolytic subunit hydrolyzes proteins to small peptides%3B with the ATPase subunits ClpA or ClpX%2C ClpP degrades specific substrates gene gene2626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2619 SCO2620 SCO2620 tig tig 2846000 2847406 - trigger factor Tig%3B RopA%3B peptidyl-prolyl cis/trans isomerase%3B promotes folding of newly synthesized proteins%3B binds ribosomal 50S subunit%3B forms a homodimer gene gene2627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2620 SCO2621 SCO2621 SCC80.06c SCC80.06c 2847983 2848177 - hypothetical protein SCC80.06c%2C membarne protein%2C len: 64 aa%3B similar to TR:Q9RJX5 (EMBL:AL133210) Streptomyces coelicolor hypothetical 6.6 kDa protein SCG11A.26c%2C 64 aa%3B fasta scores: opt: 175 z-score: 234.0 E(): 1.6e-05%3B 46.0%25 identity in 63 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2621 SCO2622 SCO2622 SCC80.07 SCC80.07 2848812 2849981 + hypothetical protein SCC80.07%2C possible integral membrane protein%2C len: 389 aa%3B similar to TR:O31660 (EMBL:Z99111) Bacillus subtilis YkrP protein%2C 340 aa%3B fasta scores: opt: 590 z-score: 707.1 E(): 7.2e-32%3B 32.0%25 identity in 341 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2622 SCO2623 SCO2623 SCC80.08c SCC80.08c 2849992 2850486 - hypothetical protein SCC80.08c%2C hypothetical protein%2C len: 164 aa%3B similar to N-terminal domain of SW:RELA_CORGL (EMBL:AF038651) Corynebacterium glutamicum GTP pyrophosphokinase (EC 2.7.6.5) RelA%2C 760 aa%3B fasta scores: opt: 162 z-score: 170.8 E(): 0.054%3B 33.6%25 identity in 149 aa overlap. Contains 3x conserved repeat: MPP gene gene2632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2623 SCO2624 SCO2624 SCC80.09c SCC80.09c 2850510 2851697 - hypothetical protein SCC80.09c%2C possible integral membrane protein%2C len: 395 aa%3B similar to TR:Q9RL36 (EMBL:AL121596) Streptomyces coelicolor hypothetical 29.6 kDa protein SCF51A.29c%2C 284 aa%3B fasta scores: opt: 269 z-score: 309.0 E(): 1.1e-09%3B 31.0%25 identity in 258 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2624 SCO2625 SCO2625 SCC80.10 SCC80.10 2851911 2853152 + hypothetical protein SCC80.10%2C hypothetical protein%2C len: 413 aa%3B similar to TR:CAB94090 (EMBL:AL358692) Streptomyces coelicolor conserved hypothetical protein SCD66.23%2C 418 aa%3B fasta scores: opt: 698 z-score: 807.3 E(): 0%3B 35.8%25 identity in 419 aa overlap gene gene2634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2625 SCO2626 SCO2626 SCC80.11c SCC80.11c 2853163 2854005 - DNA repair hydrolase (fragment) SCC80.11c%2C probable DNA repair hydrolase (fragment)%2C len: >306 aa%3B similar to SW:FPG_ECOLI (EMBL:M86305) Escherichia coli formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) MutM%2C 269 aa%3B fasta scores: opt: 347 z-score: 395.3 E(): 1.7e-14%3B 31.6%25 identity in 209 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco%2C Formamidopyrimidine-DNA glycosylase and match to Prosite entry gene gene2635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2626 SCO2627 SCO2627 SC8E4.02c SC8E4.02c 2854112 2854591 - ribose-5-phosphate isomerase B catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate%3B enzyme from E. coli shows allose 6-phosphate isomerase activity gene gene2636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2627 SCO2628 SCO2628 SC8E4.03 SC8E4.03 2854806 2856074 + amino acid permease SC8E4.03%2C probable amino acid permease%2C len: 422 aa%3B similar to SW:GABP_BACSU (EMBL:U31756) Bacillus subtilis GABA permease (4-amino butyrate transport carrier) GabP%2C 469 aa%3B fasta scores: opt: 1479 z-score: 1502.0 E(): 0%3B 58.5%25 identity in 366 aa overlap%2C to SW:GABP_ECOLI (EMBL:M88334) Escherichia coli GABA permease (4-amino butyrate transport carrier) GabP%2C 466 aa%3B fasta scores: opt: 1334 z-score: 1355.6 E(): 0%3B 52.4%25 identity in 372 aa overlap and to S. ceolicolor SC8E4A.01 517 aa%3B fasta scores: opt: 1367 z-score: 1291.7 E(): 0%3B 54.4%25 identity in 371 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and match to Prosite entry PS00218 Amino acid permeases signature. Contains also several possible hydrophobic membrane spanning regions gene gene2637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2628 SCO2629 SCO2629 SC8E4.04 SC8E4.04 2856104 2856250 + hypothetical protein SC8E4.04%2C membrane protein%2C len: 48 aa. Contains possible hydrophobic membrane spanning region gene gene2638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2629 SCO2630 SCO2630 SC8E4.05c SC8E4.05c 2856329 2857072 - biotin synthase SC8E4.05c%2C possible biotin synthase%2C len: 246 aa%3B similar to TR:AAF12013 (EMBL:AE002076) Deinococcus radiodurans biotin synthase DR2470%2C 229 aa%3B fasta scores: opt: 293 z-score: 315.9 E(): 3.5e-10%3B 33.0%25 identity in 209 aa overlap and to SW:BIOY_BACSH (EMBL:M29292) Bacillus sphaericus BioY protein%2C 196 aa%3B fasta scores: opt: 275 z-score: 299.1 E(): 3e-09%3B 35.5%25 identity in 155 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2630 SCO2631 SCO2631 SC8E4A.01 SC8E4A.01 2857300 2858685 + amino acid permease SC8E4A.01%2C probable amino acid permease%2C len: 461 aa%3B similar to C-terminal domain of SW:GABP_BACSU (EMBL:U31756) Bacillus subtilis GABA permease (4-amino butyrate transport carrier) GabP%2C 469 aa%3B fasta scores: opt: 1330 z-score: 1240.9 E(): 0%3B 42.9%25 identity in 448 aa overlap and to SW:GABP_ECOLI (EMBL:M88334) Escherichia coli GABA permease (4-amino butyrate transport carrier) GabP%2C 466 aa%3B fasta scores: opt: 1255 z-score: 1381.7 E(): 0%3B 41.9%25 identity in 451 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and match to Prosite entry PS00218 Amino acid permeases signature. Contains also possible hydrophobic membrane spanning regions gene gene2640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2631 SCO2632 SCO2632 SC8E4A.02 SC8E4A.02 2858918 2859937 + transposase SC8E4A.02%2C probable transposase%2C len: 338 aa%3B identical to previously sequenced TR:Q9X467 (EMBL:AF099014) Streptomyces coelicolor transposase tnpA%2C 338 aa and to TR:CAB55730 (EMBL:AL117387) Streptomyces coelicolor transposase SCF41.27%2C 318 aa%3B fasta scores: opt: 2217 z-score: 2582.6 E(): 0%3B 99.7%25 identity in 318 aa overlap gene gene2641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2632 SCO2633 SCO2633 SC8E4A.03 SC8E4A.03 2860089 2860730 + superoxide dismutase SC8E4A.03%2C sodF%2C superoxide dismutase [Fe-Zn] (EC 1.15.1.1)%2C len: 213 aa%3B identical to previously sequenced SW:SODF_STRCO (EMBL:AF012087) Streptomyces coelicolor superoxide dismutase [Fe-Zn] (EC 1.15.1.1) SodF and highly similar to SW:SODM_PROFR (PIR:S41106) Propionibacterium freudenreichii shermanii superoxide dismutase [Mn-Fe] (EC 1.15.1.1) SodA%2C 201 aa%3B fasta scores: opt: 792 z-score: 939.3 E(): 0%3B 57.9%25 identity in 202 aa overlap. Contains Pfam match to entry PF00081 sodfe%2C Iron/manganese superoxide dismutases (SODM) and match to Prosite entry PS00088 Manganese and iron superoxide dismutases signature gene gene2642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2633 SCO2634 SCO2634 SC8E4A.04c SC8E4A.04c 2860846 2861496 - hypothetical protein SC8E4A.04c%2C hypothetical protein%2C len: 216 aa%3B similar to various hypothetical proteins%2C e.g. TR:O53193 (EMBL:AL021246) Mycobacterium tuberculosis hypothetical 23.0 kD protein MTV008.22c%2C 207 aa%3B fasta scores: opt: 789 z-score: 898.4 E(): 0%3B 54.9%25 identity in 213 aa overlap gene gene2643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2634 SCO2635 SCO2635 SC8E4A.05 SC8E4A.05 2861702 2864203 + aminopeptidase SC8E4A.05%2C probable aminopeptidase%2C len: 833 aa%3B similar to SW:AMPN_STRLI (EMBL:L23172) Streptomyces lividans aminopeptidase N (EC 3.4.11.2) PepN%2C 857 aa%3B fasta scores: opt: 3002 z-score: 3413.5 E(): 0%3B 56.5%25 identity in 832 aa overlap%2C to TR:O53194 (EMBL:AL021246) Mycobacterium tuberculosis aminopeptidase MTV008.23%2C 861 aa%3B fasta scores: opt: 2215 z-score: 2517.8 E(): 0%3B 50.8%25 identity in 837 aa overlap and to S. coelicolor St8E4A.13%2C pepN%2C 857 aa%3B fasta scores: opt: 2998 z-score: 2999.1 E(): 0%3B 55.8%25 identity in 842 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1%2C Peptidase family M1 and match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature gene gene2644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2635 SCO2636 SCO2636 SC8E4A.06 SC8E4A.06 2864407 2865597 + hypothetical protein SC8E4A.06%2C unknown%2C len: 396 aa gene gene2645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2636 SCO2637 SCO2637 SC8E4A.07 SC8E4A.07 2865913 2869209 + serine protease SC8E4A.07%2C possible serine protease (hypothetical protein)%2C len: 1098 aa%3B similar to TR:O93635 (EMBL:AF015225) Thermococcus stetteri stetterlysin (fragment) PlsT%2C 891 aa%3B fasta scores: opt: 564 z-score: 570.6 E(): 2.2e-24%3B 26.0%25 identity in 918 aa overlap and to SW:SUBV_BACSU (EMBL:M76590) Bacillus subtilis minor extracellular protease VPR precursor (EC 3.4.21.-)%2C 806 aa%3B fasta scores: opt: 251 z-score: 254.0 E(): 9.7e-07%3B 23.8%25 identity in 820 aa overlap. Contains Pfam match to entry PF00082 Peptidase_S8%2C Subtilase family PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site PS00137 Serine proteases%2C subtilase family%2C histidine active site PS00138 Serine proteases%2C subtilase family%2C serine active site. Contains also possible N-terminal region peptide signal sequence gene gene2646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2637 SCO2638 SCO2638 SC8E4A.08c SC8E4A.08c 2869281 2870030 - hypothetical protein SC8E4A.08c%2C membrane protein%2C len: 249 aa. Contains possible hydrophobic membrane spanning regions gene gene2647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2638 SCO2639 SCO2639 SC8E4A.09c SC8E4A.09c 2870032 2870658 - RNA polymerase sigma factor SC8E4A.09c%2C possible RNA polymerase sigma factor%2C len: 208 aa%3B similar to TR:O53798 (EMBL:AL021958) Mycobacterium tuberculosis RNA polymerase sigma factor SigJ%2C 177 aa%3B fasta scores: opt: 221 z-score: 269.6 E(): 1.3e-07%3B 34.9%25 identity in 146 aa overlap and to SW:SIGV_BACSU (EMBL:U93874) Bacillus subtilis RNA polymerase sigma factor SigV%2C 166 aa%3B fasta scores: opt: 177 z-score: 218.8 E(): 8.9e-05%3B 28.2%25 identity in 142 aa overlap. Contains possible helix-turn-helix motif at residues 171..192 (+2.79 SD) gene gene2648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2639 SCO2640 SCO2640 asd1 asd1 2870836 2871858 + aspartate-semialdehyde dehydrogenase catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde gene gene2649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2640 SCO2641 SCO2641 SC8E4A.11 SC8E4A.11 2871981 2873168 + resistance protein SC8E4A.11%2C possible resistance protein%2C len: 395 aa%3B similar to TR:Q9ZBZ1 (EMBL:AL034355) Streptomyces coelicolor hypothetical 51.0 kD protein SCD78.06%2C 482 aa%3B fasta scores: opt: 715 z-score: 690.5 E(): 4.7e-31%3B 38.0%25 identity in 403 aa overlap and to SW:TERD_ALCSP (EMBL:M20238) Alcaligenes sp. tellurium resistance protein TerD%2C 192 aa%3B fasta scores: opt: 392 z-score: 388.1 E(): 3.3e-14%3B 40.2%25 identity in 189 aa overlap gene gene2650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2641 SCO2642 SCO2642 SC8E4A.12c SC8E4A.12c 2873181 2873657 - hypothetical protein SC8E4A.12c%2C unknown%2C len: 158 aa gene gene2651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2642 SCO2643 SCO2643 pepN pepN 2873770 2876343 + aminopeptidase N SC8E4A.13%2C pepN%2C aminopeptidase N%2C len: 857 aa%3B identical to SW:AMPN_STRLI (EMBL:L23172) Streptomyces lividans aminopeptidase N (EC 3.4.11.2) PepN%2C 857 aa and similar to SW:AMPN_LACLA (EMBL:D38040) Lactococcus lactis aminopeptidase N (EC 3.4.11.2) PepN%2C 848 aa%3B fasta scores: opt: 738 z-score: 846.7 E(): 0%3B 33.4%25 identity in 440 aa overlap and to S. coelicolor SC8E4A.05%2C 833 aa%3B fasta scores: opt: 2998 z-score: 2943.4 E(): 0%3B 55.8%25 identity in 842 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1%2C Peptidase family M1 and match ot Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature gene gene2652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2643 SCO2644 SCO2644 SC8E4A.14c SC8E4A.14c 2876450 2877352 - LysR family transcriptional regulator SC8E4A.14c%2C probable lysR-family transcriptional regulator%2C len: 300 aa%3B similar to TR:CAB62680 (EMBL:AL133422) Streptomyces coelicolor lysR-family transcriptional regulatory protein SCM1.22c%2C 301 aa%3B fasta scores: opt: 714 z-score: 790.0 E(): 0%3B 43.8%25 identity in 299 aa overlap and to TR:GLTC_BACSU (EMBL:M28509) Bacillus subtilis transcriptional regulatory protein GltC%2C 300 aa%3B fasta scores: opt: 376 z-score: 420.6 E(): 5.1e-16%3B 27.1%25 identity in 288 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein and possible helix-turn-helix motif at residues 19..40 (+4.89 SD) gene gene2653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2644 SCO2645 SCO2645 SC8E4A.15c SC8E4A.15c 2877382 2878338 - hypothetical protein SC8E4A.15c%2C possible integral membrane protein%2C len: 318 aa%3B similar to various hypothetical proteins%2C e.g. TR:O68125 (EMBL:AF010496) Rhodobacter capsulatus hypothetical 32.2 kD protein%2C 296 aa%3B fasta scores: opt: 495 z-score: 560.3 E(): 8.4e-24%3B 36.0%25 identity in 292 aa overlap and to TR:AAF10091 (EMBL:AE001910) Deinococcus radiodurans conserved hypothetical protein DR0512%2C 301 aa%3B fasta scores: opt: 351 z-score: 399.7 E(): 7.5e-15%3B 30.0%25 identity in 303 aa overlap. Contains two Pfam matches to entry PF00892 DUF6%2C Integral membrane protein and various possible hydrophobic membrane spanning regions gene gene2654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2645 SCO2646 SCO2646 SC8E4A.16c SC8E4A.16c 2878372 2879334 - hypothetical protein SC8E4A.16c%2C possible integral membrane protein%2C len: 320 aa%3B similar to SW:PECM_ERWCH (EMBL:X74409) Erwinia chrysanthemi PecM protein%2C 297 aa%3B fasta scores: opt: 781 z-score: 802.2 E(): 0%3B 43.9%25 identity in 278 aa overlap and to TR:AAF10091 (EMBL:AE001910) Deinococcus radiodurans conserved hypothetical protein DR0512%2C 301 aa%3B fasta scores: opt: 310 z-score: 324.9 E(): 1.1e-10%3B 29.0%25 identity in 286 aa overlap%3B fasta scores: opt: 748 z-score: 768.7 E(): 0%3B 46.5%25 identity in 284 aa overlap. Contains tow matches to Pfam entry PF00892 DUF6%2C Integral membrane protein and various possible hydrophobic membrane spanning regions gene gene2655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2646 SCO2647 SCO2647 SC8E4A.17 SC8E4A.17 2879447 2879965 + MarR family regulatory protein SC8E4A.17%2C probable MarR-family regulatory protein%2C len: 172 aa%3B similar to SW:PECS_ERWCH (EMBL:X74409) Erwinia chrysanthemi regulatory protein PecS%2C 166 aa%3B fasta scores: opt: 372 z-score: 442.3 E(): 3.2e-17%3B 39.6%25 identity in 149 aa overlap and to SW:MARR_SALTY (EMBL:U54468) Salmonella typhimurium multiple antibiotic resistance protein MarR%2C 144 aa%3B fasta scores: opt: 181 z-score: 223.4 E(): 5e-0%3B 28.6%25 identity in 133 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene2656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2647 SCO2648 SCO2648 SC8E4A.18c SC8E4A.18c 2880082 2880369 - hypothetical protein SC8E4A.18c%2C possible membrane protein%2C len: 95 aa. Contains possible hydrophobic membrane spanning regions gene gene2657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2648 SCO2649 SCO2649 SC8E4A.19c SC8E4A.19c 2880455 2882590 - 4-alpha-glucanotransferase SC8E4A.19c%2C probable 4-alpha-glucanotransferase%2C len: 711 aa%3B similar to SW:MALQ_MYCTU (EMBL:AL022021) Mycobacterium tuberculosis 4-alpha-glucanotransferase (EC 2.4.1.25) MalQ%2C 724 aa%3B fasta scores: opt: 2038 z-score: 2288.0 E(): 0%3B 47.9%25 identity in 727 aa overlap and to SW:MALQ_ECOLI (EMBL:M32793) Escherichia coli 4-alpha-glucanotransferase (EC 2.4.1.25) MalQ%2C 694 aa%3B fasta scores: opt: 979 z-score: 1098.2 E(): 0%3B 33.3%25 identity in 654 aa overlap gene gene2658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2649 SCO2650 SCO2650 SC8E4A.20c SC8E4A.20c 2882600 2882911 - hypothetical protein SC8E4A.20c%2C hypothetical protein%2C len: 103 aa. Contains possible N-terminal region signal peptide sequence gene gene2659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2650 SCO2651 SCO2651 SC8E4A.21c SC8E4A.21c 2883219 2883956 - dehydrogenase/reductase SC8E4A.21c%2C possible dehydrogenase/reductase ( hypothetical protein)%2C len: 245 aa%3B similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor oxidoreductase SCJ11.40%2C 250 aa%3B fasta scores: opt: 717 z-score: 778.8 E(): 0%3B 47.6%25 identity in 250 aa overlap and to SW:LINX_PSEPA (EMBL:D23722) Pseudomonas paucimobilis 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-diol dehydrogenase (EC 1.1.-.-) LinX%2C 250 aa%3B fasta scores: opt: 446 z-score: 488.9 E(): 8e-20%3B 34.3%25 identity in 248 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain. Contains possible N-terminal region signal peptide sequence dehydrogenases/reductases family signature gene gene2660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2651 SCO2652 SCO2652 SC8E4A.22 SC8E4A.22 2884084 2884518 + hypothetical protein SC8E4A.22%2C hypothetical protein%2C len: 144 aa%3B similar to TR:P71036 (EMBL:Y08559) Bacillus subtilis hypothetical 14.7 kD protein YwnA%2C 133 aa%3B fasta scores: opt: 301 z-score: 389.2 E(): 2.9e-14%3B 38.4%25 identity in 138 aa overlap gene gene2661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2652 SCO2653 SCO2653 SC8E4A.23 SC8E4A.23 2884761 2885426 + hypothetical protein SC8E4A.23%2C hypothetical protein%2C len: 221 aa%3B similar to SW:Y089_MYCTU (EMBL:Z74410) Mycobacterium tuberculosis methyltransferase RV0089 (EC 2.1.1.-) MTCY251.07%2C 197aa%2C fasta scores: opt: 258 z-score: 309.5 E(): 7.9e-10%3B 29.6%25 identity in 203 aa overlap and to TR:AAF09618 (EMBL:AE001866) Deinococcus radiodurans methyltransferase%2C DR0026%2C 269 aa%3B fasta scores: opt: 188 z-score: 226.5 E(): 3.3e-05%3B 32.7%25 identity in 168 aa overlap gene gene2662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2653 SCO2654 SCO2654 SC8E4A.24 SC8E4A.24 2885483 2886067 + hypothetical protein SC8E4A.24%2C hypothetical protein%2C len: 194 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB56360 (EMBL:AL118514) Streptomyces coelicolor hypothetical 21.6 kD protein SCD25.16c%2C 194 aa%3B fasta scores: opt: 700 z-score: 857.1 E(): 0%3B 58.5%25 identity in 188 aa overlap gene gene2663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2654 SCO2655 SCO2655 SC8E4A.25c SC8E4A.25c 2886105 2886641 - hypothetical protein SC8E4A.25c%2C hypothetical protein%2C len: 178 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9X7B4 (EMBL:AL049913) Mycobacterium leprae hypothetical 23.9 kD protein MLCB1610.15%2C 215 aa%3B fasta scores: opt: 589 z-score: 757.6 E(): 0%3B 52.8%25 identity in 161 aa overlap. Contains Pfam match to entry PF01844 HNH%2C HNH endonuclease gene gene2664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2655 SCO2656 SCO2656 SC8E4A.26 SC8E4A.26 2886859 2888085 + hypothetical protein SC8E4A.26%2C possible membrane protein%2C len: 408 aa%3B similar to various hypothetical proteins%2C e.g. TR:Q9XA89 (EMBL:AL096837) Streptomyces coelicolor hypothetical 36.1 kD protein SCF43A.26c%2C 333 aa%3B fasta scores: opt: 661 z-score: 668.4 E(): 8.1e-30%3B 42.3%25 identity in 317 aa overlap. Contains Pfam match to entry PF00924 UPF0003%2C Uncharacterized protein family UPF0003 and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains also possible hydrophobic membrane spanning regions gene gene2665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2656 SCO2657 SCO2657 SC8E4A.27 SC8E4A.27 2888297 2889526 + transcriptional regulator SC8E4A.27%2C possible ROK-family transcriptional regulatory protein%2C len: 409 aa%3B similar to TR:O69941 (EMBL:AL023862) Streptomyces coelicolor hypothetical ROK family protein (fragment) SC3F9.01%2C 403 aa%3B fasta scores: opt: 456 z-score: 480.7 E(): 2.3e-19%3B 30.8%25 identity in 396 aa overlap and to SW:XYLR_CALSR (EMBL:L18965) Caldicellulosiruptor sp. xylose repressor XylR%2C 399 aa%3B fasta scores: opt: 381 z-score: 402.9 E(): 5e-15%3B 25.2%25 identity in 361 aa overlap. Contains Pfam match to entry PF00325 crp%2C Bacterial regulatory proteins%2C crp family and Pfam match to entry PF00480 ROK%2C ROK family. Contains also possible helix-turn-helix motif at residues 32..53 (+5.09 SD) gene gene2666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2657 SCO2658 SCO2658 SC6D10.01 SC6D10.01 2889601 2890938 + sugar-binding protein SC6D10.01%2C possible sugar-binding protein (partial)%2C len: > 273 aa%3B similar to TR:CAB49101 (EMBL:AJ248283) Pyrococcus abyssi maltose-binding periplasmic protein precursor MalE%2C 453 aa%3B fasta scores: opt: 246 z-score: 288.7 E(): 1.1e-08%3B 24.0%25 identity in 271 aa overlap and to SW:MALX_STRPN (EMBL:L08611) Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX%2C 423 aa%3B fasta scores: opt: 184 z-score: 217.6 E(): 0.0001%3B 22.9%25 identity in 279 aa overlap~SC8E4A.28%2C possible sugar-binding protein (fragment)%2C len: >205 aa%3B similar to TR:O87856 (EMBL:AL031013) Streptomyces coelicolor sugar binding protein SC8A6.22%2C 438 aa%3B fasta scores: opt: 314 z-score: 373.2 E(): 2.5e-13%3B 38.8%25 identity in 206 aa overlap and to TR:O51923 (EMBL:AF012836) Thermococcus litoralis trehalose/maltose binding protein MalE%2C 450 aa%3B fasta scores: opt: 272 z-score: 323.9 E(): 1.4e-10%3B 31.7%25 identity in 183 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal sequence peptide gene gene2667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2658 SCO2659 SCO2659 SC6D10.02 SC6D10.02 2890945 2891889 + sugar transport system permease SC6D10.02%2C possible sugar transport system permease%2C len: 314 aa%3B similar to TR:Q9X6C4 (EMBL:AF135398) Thermus brockianus integral membrane protein BdtF%2C 280 aa%3B fasta scores: opt: 498 z-score: 582.4 E(): 5e-25%3B 35.4%25 identity in 288 aa overlap and to SW:LACF_AGRRD (EMBL:X66596) Agrobacterium radiobacter lactose transport system permease LacF%2C 298 aa%3B fasta scores: opt: 437 z-score: 511.6 E(): 4.4e-21%3B 31.1%25 identity in 315 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene2668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2659 SCO2660 SCO2660 SC6D10.03 SC6D10.03 2891886 2892797 + sugar transport membrane protein SC6D10.03%2C possible sugar transport membrane protein%2C len: 303 aa%3B similar to TR:CAB59597 (EMBL:AL132662) Streptomyces coelicolor probable sugar transport inner membrane protein SCF11.20%2C 299 aa%3B fasta scores: opt: 662 z-score: 806.9 E(): 0%3B 38.4%25 identity in 297 aa overlap and to SW:YESQ_BACSU (EMBL:Z99107) Bacillus subtilis probable ABC transporter permease YesQ%2C 296 aa%3B fasta scores: opt: 588 z-score: 717.5 E(): 1.5e-32%3B 33.2%25 identity in 304 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains possible hydrophobic membrane spanning regions gene gene2669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2660 SCO2661 SCO2661 SC6D10.04 SC6D10.04 2892805 2894070 + sugar hydrolase SC6D10.04%2C possible sugar hydrolase%2C len: 421 aa%3B similar to SW:CELF_ECOLI (EMBL:X52890) Escherichia coli 6-phospho-beta-glucosidase (EC 3.2.1.86) CelF%2C 450 aa%3B fasta scores: opt: 556 z-score: 624.0 E(): 2.4e-27%3B 36.0%25 identity in 431 aa overlap and to SW:AGAL_ECOLI (EMBL:X04894) Escherichia coli alpha-galactosidase (EC 3.2.1.22) (melibiase) MelA%2C 451 aa%3B fasta scores: opt: 300 z-score: 338.4 E(): 1.9e-11%3B 25.5%25 identity in 459 aa overlap gene gene2670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2661 SCO2662 SCO2662 SC6D10.05 SC6D10.05 2894115 2895032 + kinase SC6D10.05%2C possible kinase%2C len: 305 aa%3B similar to TR:CAB61848 (EMBL:AJ242910) Homo sapiens N-acetylglucosamine kinase (EC 2.7.1.59)%2C 344 aa%3B fasta scores: opt: 192 z-score: 223.6 E(): 4.8e-05%3B 24.5%25 identity in 253 aa overlap and to TR:CAB61849 (EMBL:AJ242909) Mus musculus N-acetylglucosamine kinase (EC 2.7.1.59)%2C 343 aa%3B fasta scores: opt: 180 z-score: 210.1 E(): 0.00027%3B 24.4%25 identity in 250 aa overlap gene gene2671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2662 SCO2663 SCO2663 SC6D10.06 SC6D10.06 2895262 2896551 + hypothetical protein SC6D10.06%2C possible hypothetical protein%2C len: 429 aa%3B similar to TR:P96258 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 47.1 kD protein MTCY22G10.08c%2C 439 aa%3B fasta scores: opt: 430 z-score: 482.8 E(): 1.8e-19%3B 30.9%25 identity in 427 aa overlap and to TR:Q9ZBL6 (EMBL:AL035159) Mycobacterium leprae membrane protein MLCB1450.21c%2C 403 aa%3B fasta scores: opt: 412 z-score: 463.3 E(): 2.1e-18%3B 29.6%25 identity in 423 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2663 SCO2664 SCO2664 SC6D10.07 SC6D10.07 2896634 2897692 + sugar-binding protein SC6D10.07%2C possible sugar-binding protein%2C len: 352 aa%3B similar to TR:O34563 (EMBL:Z99117) Bacillus subtilis glutamine ABC transporter (glutamine-binding protein) GlnH%2C 27 33%3B fasta scores: opt: 474 z-score: 507.4 E(): 7.5e-21%3B 32.6%25 identity in 285 aa overlap and to SW:GLNH_BACST (EMBL:M61017) Bacillus stearothermophilus glutamine-binding protein precursor GlnH%2C 262 aa%3B fasta scores: opt: 414 z-score: 444.6 E(): 2.4e-17%3B 33.1%25 identity in 236 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3%2C Bacterial extracellular solute-binding proteins%2C family 3%2C to Prosite entry PS01039 Bacterial extracellular solute-binding proteins%2C family 3 signature and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site plus possible N-terminal region signal sequence peptide gene gene2673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2664 SCO2665 SCO2665 SC6D10.08 SC6D10.08 2897763 2899097 + hypothetical protein SC6D10.08%2C unknown%2C len: 444 aa. Contains possible coiled-coil region gene gene2674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2665 SCO2666 SCO2666 SC6D10.09 SC6D10.09 2899173 2901884 + Ser/Thr protein kinase SC6D10.09%2C possible Ser/Thr protein kinase%2C len: 903 aa%3B similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae Ser/Thr kinase MLCB1450.19c%2C 763 aa%3B fasta scores: opt: 1045 z-score: 821.3 E(): 0%3B 42.0%25 identity in 793 aa overlap and to SW:PKN2_MYXXA (EMBL:M94857) Myxococcus xanthus Ser/Thr protein kinase Pkn2 (EC 2.7.1.-)%2C 830 aa%3B fasta scores: opt: 301 z-score: 243.3 E(): 3.8e-06%3B 28.9%25 identity in 433 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene2675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2666 SCO2667 SCO2667 SC6D10.10 SC6D10.10 2901888 2903336 + hypothetical protein SC6D10.10%2C unknown%2C len: 482 aa gene gene2676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2667 SCO2668 SCO2668 SC6D10.11 SC6D10.11 2903439 2904797 + hypothetical protein SC6D10.11%2C hypothetical protein%2C len: 452 aa%3B similar to TR:Y103_SYNY3 (EMBL:D64004) Synechocystis sp. hypothetical 45.8 kD protein SLL0103%2C 420 aa%3B fasta scores: opt: 265 z-score: 295.0 E(): 5.1e-09%3B 26.6%25 identity in 354 aa overlap gene gene2677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2668 SCO2669 SCO2669 SC6D10.12 SC6D10.12 2904844 2906658 + hypothetical protein SC6D10.12%2C unknown%2C len: 604 aa. Glycine and proline rich. Contains Pfam match to entry PF00498 FHA%2C FHA domain gene gene2678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2669 SCO2670 SCO2670 SC6D10.13c SC6D10.13c 2906677 2907651 - O-methyltransferase SC6D10.13c%2C probable O-methyltransferase%2C len: 324 aa%3B similar to TR:O30199 (EMBL:AE001104) Archaeoglobus fulgidus L-isoaspartyl protein carboxyl methyltransferase AF0036%2C 216 aa%3B fasta scores: opt: 373 z-score: 428.9 E(): 1.8e-16%3B 36.8%25 identity in 209 aa overlap and to SW:PIMT_METJA (EMBL:U67474) Methanococcus jannaschii protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77)%2C 215 aa%3B fasta scores: opt: 356 z-score: 407.3 E(): 2.8e-15%3B 42.1%25 identity in 140 aa overlap. Contains Pfam match to entry PF01135 PCMT%2C Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) and match to Prosite entry PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature gene gene2679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2670 SCO2671 SCO2671 SC6D10.14 SC6D10.14 2907738 2908151 + globin SC6D10.14%2C possible globin%2C len: 137 aa%3B similar to TR:O53197 (EMBL:AL021246) Mycobacterium tuberculosis globin%2C 128 aa%3B fasta scores: opt: 466 z-score: 620.8 E(): 3.6e-27%3B 53.6%25 identity in 125 aa overlap and to SW:GLBN_NOSSN (EMBL:L47979) Nostoc sp. cyanoglobin GlbN%2C 118 aa%3B fasta scores: opt: 170 z-score: 236.1 E(): 9.7e-06%3B 25.2%25 identity in 119 aa overlap. Contains Pfam match to entry PF01152 Bac_globin%2C Protozoan/cyanobacterial globin gene gene2680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2671 SCO2672 SCO2672 SC6D10.15 SC6D10.15 2908366 2911707 + hypothetical protein SC6D10.15%2C possible membrane protein%2C len: 1113 aa%3B similar to TR:O86657 (EMBL:AL031182) Streptomyces coelicolor integral membrane protein (fragment) SC4A2.01c%2C 653 aa%3B fasta scores: opt: 220 z-score: 208.2 E(): 0.00035%3B 27.8%25 identity in 654 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene2681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2672 SCO2673 SCO2673 SC6D10.16 SC6D10.16 2911856 2914579 + hypothetical protein SC6D10.16%2C possible membrane protein%2C len: 907 aa%3B similar to TR:O86634 (EMBL:AL031155) Streptomyces coelicolor hypothetical 26.5 kD protein (fragment) SC3A7.33c%2C 259 aa%3B fasta scores: opt: 166 z-score: 178.0 E(): 0.017%3B 33.7%25 identity in 249 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. Contains also possible hydrophobic membrane spanning regions gene gene2682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2673 SCO2674 SCO2674 SC6D10.17 SC6D10.17 2914632 2915591 + ABC transporter ATP-binding protein SC6D10.17%2C probable ABC transporter ATP-binding protein%2C len: 319 aa%3B similar to various ABC transporter%2C ATP-binding proteins%2C e.g. TR:O28803 (EMBL:AE001001) Archaeoglobus fulgidus ABC transporter ATP-binding protein AF1469%2C 226 aa%3B fasta scores: opt: 631 z-score: 717.1 E(): 1.6e-32%3B 45.7%25 identity in 219 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene2683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2674 SCO2675 SCO2675 SC6D10.18c SC6D10.18c 2915616 2916332 - hypothetical protein SC6D10.18c%2C unknown%2C len: 238 aa gene gene2684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2675 SCO2676 SCO2676 SC6D10.19c SC6D10.19c 2916335 2916745 - hypothetical protein SC6D10.19c%2C hypothetical protein%2C len: 136 aa%3B similar to various hypothetical proteins%2C e.g. TR:O53202 (EMBL:AL021246) Mycobacterium tuberculosis hypothetical 15.8 kD protein MTV008.31c%2C 138 aa%3B fasta scores: opt: 236 z-score: 318.7 E(): 2.4e-10%3B 34.1%25 identity in 126 aa overlap gene gene2685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2676 SCO2677 SCO2677 SC6D10.20c SC6D10.20c 2916748 2918391 - ABC transporter ATP-binding protein ChvD%3B in Agrobacterium tumefaciens%2C mutations in both Walker boxes were found to affect virulence gene gene2686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2677 SCO2678 SCO2678 SC6D10.21 SC6D10.21 2918653 2919168 + hypothetical protein SC6D10.21%2C hypothetical protein%2C len: 171 aa%3B similar to TR:CAB55735 (EMBL:AL117387) Streptomyces coelicolor hypothetical protein SCF41.32c%2C fasta scores: opt: 399 z-score: 488.3 E(): 8.7e-20%3B 45.6%25 identity in 169 aa overlap gene gene2687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2678 SCO2679 SCO2679 SC6D10.22c SC6D10.22c 2919307 2919678 - lipoprotein SC6D10.22c%2C possible lipoprotein%2C len: 123 aa%3B similar to TR:O86703 (EMBL:AL031515) Streptomyces coelicolor hypothetical protein SC5C7.06%2C 318 aa%3B fasta scores: opt: 99 z-score: 130.8 E(): 7.1%3B 29.8%25 identity in 94 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene2688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2679 SCO2680 SCO2680 SC6D10.23 SC6D10.23 2920007 2920477 + hypothetical protein SCC61A.01%2C conserved hypothetical protein%2C partial CDS%2C len: >153 aa%3B similar to others of unknown function from Streptomyces coelicolor eg. TR:O86768 (EMBL:AL031035) ATP /GTP-binding protein (886 aa) fasta scores%3B opt: 457%2C z-score: 460.9%2C E(): 3.2e-18%2C 48.6%25 identity in 146 aa overlap. Searches suggest a frameshift mutation between CDSs 01 and 02.~SC6D10.23%2C hypothetical protein (partial)%2C len: >85 aa%3B highly similar to N-terminal region of TR:O86768 (EMBL:AL031035) Streptomyces coelicolor ATP /GTP-binding%3D 333 z-score: 478.0 E(): 3.2e-19%3B 59.4%25 identity in 69 aa overlap gene gene2689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2680 SCO2681 SCO2681 SCC61A.02 SCC61A.02 2920476 2922815 + ATP /GTP-binding protein SCC61A.02%2C possible ATP/GTP-binding protein%2C partial CDS%2C len: 727aa%3B similar to others from Streptomyces coelicolor eg. TR:CAB77406 (EMBL:AL160431) ATP /GTP-binding%3D z-score: 2917.3%2C E(): 0%2C 58.7%25 identity in 719 aa overlap. Hydrophilic C-terminal region contains 6 x 42 amino acid repeat (LGE(DEN)HP(DHR)TL(DA)SAH(SY)L(AG)(AVSH)(AVGTS)(LI) (HS)(DANY)(LF)GQ(YPD)(GAVT)(EDQ)A(RH)(RS)M(HDV)E(DY)TL(ED ) (RG)RRR(TI). Also contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) at the N-terminus. Searches suggest a frameshift mutation between CDSs 01 and 02. gene gene2690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2681 SCO2682 SCO2682 SCC61A.03c SCC61A.03c 2922880 2924292 - hypothetical protein SCC61A.03c%2C possible membrane protein%2C len: 470 aa%3B contains possible membrane-spanning hydrophobic regions. gene gene2691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2682 SCO2683 SCO2683 SCC61A.04c SCC61A.04c 2924515 2924985 - single-strand DNA-binding protein SCC61A.04c%2C possible single-strand DNA-binding protein%2C len: 156 aa%3B similar to many eg. SW:P71711 (SSB_MYCTU) single-strand binding protein from Mycobacterium tuberculosis (164 aa) fasta scores%3B opt: 259%2C z-score: 301.8%2C E(): 2.4e-09%2C 35.5%25 identity in 141 aa overlap and TR:Q9X8U3 (EMBL:AL049826) single-strand binding protein from Streptomyces coelicolor (199 aa) fasta scores%3B opt: 261%2C z-score: 302.7%2C E(): 2.1e-09%2C 42.5%25 identity in 120 aa overlap. Contains Pfam match to entry PF00436 SSB%2C Single-strand binding protein family. gene gene2692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2683 SCO2684 SCO2684 SCC61A.05c SCC61A.05c 2925258 2927738 - ATP-binding membrane protein SCC61A.05c%2C possible ATP-binding membrane protein%2C len: 826aa%3B no significant database similarities%2C N-terminal region rich in glycine/arginine/asparagine%2C C-terminal contains possible membrane-spanning hydrophobic region. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Note possible alternative downstream translational start sites. gene gene2693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2684 SCO2685 SCO2685 SCC61A.06c SCC61A.06c 2927742 2929349 - ATP-binding protein SCC61A.06c%2C possible ATP-binding protein%2C len: 535aa%3B no significant database similarities. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Note possible alternative downstream translational start sites. gene gene2694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2685 SCO2686 SCO2686 SCC61A.07c SCC61A.07c 2929823 2930839 - LuxR family transcriptional regulator SCC61A.07c%2C possible luxR-family transcriptional regulator%2C len: 338aa%3B similar to many eg. TR:Q56084 (EMBL:D63904) erythropoiesis-stimulating protein from Streptomyces thermoviolaceus (334 aa) fasta scores%3B opt: 393%2C z-score: 460.3%2C E(): 3.5e-18%2C 32.5%25 identity in 295 aa overlap and SW:Q01108 (BRPA_STRHY) bialaphos biosynthetic pathway regulatory protein from Streptomyces hygroscopicus (256 aa) fasta scores%3B opt: 178%2C z-score: 213.5%2C E(): 0.0002%2C 25.1%25 identity in 255 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and helix-turn-helix motif 276-297aa. gene gene2696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2686 SCO2687 SCO2687 ribA ribA 2931148 2931792 + GTP cyclohydrolase II catalyzes the conversion of GTP to formate and 2%2C5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate gene gene2697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2687 SCO2688 SCO2688 ribD ribD 2931848 2932993 + riboflavin-specific deaminase SCC61A.09%2C ribD%2C riboflavin-specific deaminase%2C len: 381aa%3B similar to many eg. SW:P25539 (RIBD_ECOLI) ribD%2C riboflavin-specific deaminase from Escherichia coli (367 aa) fasta scores%3B opt: 581%2C z-score: 642.9%2C E(): 2.4e-28%2C 36.3%25 identity in 386 aa overlap. Contains Pfam match to entry PF01872 RibD_C%2C RibD C-terminal domain%2C Pfam match to entry PF00383 dCMP_cyt_deam%2C Cytidine and deoxycytidylate deaminase zinc-binding region and PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. gene gene2698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2688 SCO2689 SCO2689 SCC61A.10 SCC61A.10 2932990 2934117 + hypothetical protein SCC61A.10%2C possible membrane protein%2C len: 375aa%3B contains possible membrane-spanning hydrophobic regions. gene gene2699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2689 SCO2690 SCO2690 SCC61A.11 SCC61A.11 2934114 2935478 + membrane transport protein SCC61A.11%2C possible membrane transport protein%2C len: 454aa%3B similar to eg. TR:Q54309 (EMBL:X86780) membrane transport protein from rapamycin biosynthetic gene cluster of Streptomyces hygroscopicus (453 aa) fasta scores%3B opt: 546%2C z-score: 566.6%2C E(): 4.2e-24%2C 27.7%25 identity in 452 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene2700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2690 SCO2691 SCO2691 SCC61A.12 SCC61A.12 2935475 2936632 + hypothetical protein SCC61A.12%2C unknown%2C len: 385aa gene gene2701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2691 SCO2692 SCO2692 SCC61A.13 SCC61A.13 2936812 2938692 + repetative protein SCC61A.13%2C possible repetetive protein%2C len: 626 aa%3B contains eleven (weak) Pfam matches to entry PF00400 WD40%2C WD domain%2C G-beta repeat and three Prosite matches to PS00678 Trp-Asp (WD) repeats signature. gene gene2702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2692 SCO2693 SCO2693 SCC61A.14 SCC61A.14 2938689 2939690 + oxygenase SCC61A.14%2C possible oxygenase (hypothetical protein)%2C len: 333 aa%3B similar to others from Streptomyces spp. e.g. TR:Q05582 (EMBL:L06214) clavaminate synthase 2 from Streptomyces clavuligerus (325 aa) fasta scores%3B opt: 582%2C z-score: 633.2%2C E(): 8.2e-28%2C 37.5%25 identity in 317 aa overlap and TR:Q9Z4Z5 (EMBL:AL035707) oxygenase from Streptomyces coelicolor (333 aa) opt: 1205%2C z-score: 1302.5%2C E(): 0%2C 59.4%25 identity in 320 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2693 SCO2694 SCO2694 SCC61A.15 SCC61A.15 2939719 2940261 + hypothetical protein SCC61A.15%2C unknown%2C len: 180aa gene gene2704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2694 SCO2695 SCO2695 SCC61A.16 SCC61A.16 2940382 2941152 + hypothetical protein SCC61A.16%2C unknown%2C len: 256 aa%3B region similar to others eg. TR:O69671 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (425 aa) fasta scores%3B opt: 266%2C z-score: 305.4%2C E(): 1.5e-09%2C 32.3%25 identity in 248 aa overlap. gene gene2705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2695 SCO2696 SCO2696 SCC61A.17 SCC61A.17 2941209 2942201 + 2-hydroxyacid dehydrogenase SCC61A.17%2C possible 2-hydroxyacid-family dehydrogenase%2C len: 330 aa%3B similar to many e.g. SW:P35136 (SERA_BACSU) D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (525 aa) fasta scores%3B opt: 519%2C z-score: 581.8%2C E(): 6e-25%2C 35.7%25 identity in 294 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases. gene gene2706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2696 SCO2697 SCO2697 SCC61A.18c SCC61A.18c 2942208 2942786 - hypothetical protein SCC61A.18c%2C possible hypothetical protein%2C len: 192aa%3B contains a possible cleavable N-terminal signal sequence. gene gene2707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2697 SCO2698 SCO2698 SCC61A.19 SCC61A.19 2942785 2942904 + small hydrophilic protein SCC61A.19%2C possible small hydrophilic protein%2C len: 39 aa gene gene2708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2698 SCO2699 SCO2699 SCC61A.20 SCC61A.20 2943092 2943364 + small membrane protein SCC61A.20%2C possible small membrane protein%2C len: 90 aa%3B strongly similar to others from Streptomyces coelicolor eg. TR:CAB75306 (EMBL:AL139164) small hypothetical protein (75 aa) fasta scores%3B opt: 338%2C z-score: 381.0%2C E(): 9.2e-14%2C 68.4%25 identity in 76 aa overlap and neighbouring CDS SCC61A.26c. Contains possible hydrophobic membrane spanning region gene gene2709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2699 SCO2700 SCO2700 melC2 melC2 2943456 2944322 - tyrosinase SCC61A.21c%2C melC2%2C tyrosinase (monophenol monooxygenase)%2C len: 288 aa%3B strongly similar to many eg. SW:P06845 (TYRO_STRGA) tyrosinase from Streptomyces glaucescens (273 aa) fasta scores%3B opt: 682%2C z-score: 837.0%2C E(): 0%2C 52.0%25 identity in 277 aa overlap. Contains Pfam match to entry PF00264 tyrosinase%2C Common central domain of tyrosinase Prosite match to PS00497 Tyrosinase CuA-binding region signature and Prosite match to PS00498 Tyrosinase and hemocyanins CuB-binding region signature. gene gene2710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2700 SCO2701 SCO2701 melC1 melC1 2944306 2944875 - tyrosinase co-factor SCC61A.22c%2C melC1%2C tyrosinase co-factor%2C len: 189 aa%3B similar to others from Streptomyces spp. e.g. SW:P55047 (TYRT_STRGA) tyrosinase co-factor from Streptomyces glaucescens (134 aa) fasta scores%3B opt: 304%2C z-score: 323.4%2C E(): 1.5e-10%2C 44.4%25 identity in 133 aa overlap gene gene2711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2701 SCO2702 SCO2702 SCC61A.23c SCC61A.23c 2944995 2945510 - hypothetical protein SCC61A.23c%2C possible hypothetical protein%2C len: 171aa%3B contains a possible cleavable N-terminal signal sequence. gene gene2712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2702 SCO2703 SCO2703 SCC61A.24c SCC61A.24c 2945615 2945917 - hypothetical protein SCC61A.24c%2C possible membrane protein%2C len: 100 aa%3B similar to TR:CAB75306 (EMBL:AL139164) small hypothetical protein from Streptomyces coelicolor (75 aa) fasta scores%3B opt: 114%2C z-score: 155.1%2C E(): 0.35%2C 43.1%25 identity in 51 aa overlap. Contains possible hydrophobic membrane spanning region gene gene2713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2703 SCO2704 SCO2704 SCC61A.25c SCC61A.25c 2946094 2946828 - hypothetical protein SCC61A.25c%2C possible hypothetical protein%2C len: 244aa%3B contains a possible cleavable N-terminal signal sequence. gene gene2714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2704 SCO2705 SCO2705 SCC61A.26c SCC61A.26c 2947104 2947370 - hypothetical protein SCC61A.26c%2C possible membrane protein%2C len: 88 aa%3B similar to others from Streptomyces coelicolor eg. TR:CAB75306 (EMBL:AL139164) small hypothetical protein (75 aa) fasta scores%3B opt: 330%2C z-score: 389.5%2C E(): 3.1e-14%2C 72.1%25 identity in 68 aa overlap and neighbouring CDS SCC61A.20. Contains possible hydrophobic membrane spanning region gene gene2715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2705 SCO2706 SCO2706 SCC61A.27 SCC61A.27 2947584 2948894 + transferase SCC61A.27%2C possible transferase%2C len: 436 aa%3B similar to many proposed to be involved in LPS biosynthesis e.g. SW:LPSB_RHIME (EMBL:AF193023) LpsB from lipopolysaccharide biosynthesis cluster of Rhizobium meliloti. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1. Also contains a TTA encoded leucine close to the N-terminus%2C possible target for bldA regulation gene gene2716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2706 SCO2707 SCO2707 SCC61A.28 SCC61A.28 2948891 2950345 + transferase SCC61A.28%2C possible transferase (membrane-associated)%2C len: 484 aa%3B similar to many proposed to be involved in LPS biosynthesis e.g. SW:P71241 (WCAJ_ECOLI) colanic biosynthesis UDP-glucose lipid carrier transferase from Escherichia coli (464 aa) fasta scores%3B opt: 493%2C z-score: 540.1%2C E(): 1.3e-22%2C 30.9%25 identity in 376 aa overlap. Contains possible membrane-spanning hydrophobic regions gene gene2717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2707 SCO2708 SCO2708 SCC61A.29 SCC61A.29 2950351 2951667 + hypothetical protein SCC61A.29%2C possible integral membrane protein%2C len: 438aa%3B weakly similar to TR:Q51524 (EMBL:X83916) PilO%2C required for glycosylation of Pseudomonas aeruginosa 1244 pilin (461 aa) fasta scores%3B opt: 165%2C z-score: 184.2%2C E(): 0.0085%2C 25.7%25 identity in 439 aa overlap. gene gene2718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2708 SCO2709 SCO2709 SCC61A.30 SCC61A.30 2952033 2953604 + hypothetical protein SCC61A.30%2C possible integral membrane protein%2C len: 523aa%3B similar to many proposed virulence factors eg. SW:P37169 (MVIN_SALTY) virulence factor MviN from Salmonella typhimurium (524 aa) fasta scores%3B opt: 475%2C z-score: 495.1%2C E(): 4e-20%2C 28.8%25 identity in 423 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2709 SCO2710 SCO2710 SCC61A.31 SCC61A.31 2953648 2954337 + polysaccharide deacetylase SCC61A.31%2C possible polysaccharide deacetylase%2C len: 229 aa%3B weakly similar to many e.g. TR:Q9XDJ5 (EMBL:AF048749) deacetylase from Bacteroides fragilis (259 aa) fasta scores%3B opt: 135%2C z-score: 169.7%2C E(): 0.054%2C 22.6%25 identity in 137 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet%2C Polysaccharide deacetylase. gene gene2720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2710 SCO2711 SCO2711 SCC61A.32 SCC61A.32 2954348 2955550 + glycosyl transferase SCC61A.32%2C possible glycosyl transferase%2C len: 400 aa%3B weakly similar to others proposed to be involved in LPS biosynthesis e.g. TR:AAF23993 (EMBL:AF035937) from Pseudomonas aeruginosa (383 aa) fasta scores%3B opt: 381%2C z-score: 364.0%2C E(): 8.2e-13%2C 28.6%25 identity in 392 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1. gene gene2721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2711 SCO2712 SCO2712 SCC61A.33 SCC61A.33 2955547 2956266 + hypothetical protein SCC61A.33%2C possible membrane protein%2C len: 239aa%3B weakly similar to TR:Q9X4U6 (EMBL:AF118389) from cps locus of Streptococcus suis serotype 2 (229 aa) fasta scores%3B opt: 161%2C z-score: 172.0%2C E(): 0.04%2C 28.4%25 identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene2722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2712 SCO2713 SCO2713 SCC61A.34 SCC61A.34 2956263 2957411 + hypothetical protein SCC61A.34%2C unknown%2C len: 382aa gene gene2723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2713 SCO2714 SCO2714 SCC61A.35 SCC61A.35 2957449 2958636 - hypothetical protein SCC61A.35%2C possible hypothetical protein%2C len: 395aa%3B contains a possible non-cleavable N-terminal signal sequence. gene gene2724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2714 SCO2715 SCO2715 SCC61A.36 SCC61A.36 2958781 2960079 + hypothetical protein SCC61A.36%2C unknown%2C len: 432aa gene gene2725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2715 SCO2716 SCO2716 SCC46.01c SCC46.01c 2960170 2960928 - hypothetical protein SCC46.01c%2C possible hypothetical protein%2C len: > 171 aa%3B similar to TR:Q9X7U2 (EMBL:AL049863) Streptomyces coelicolor hypothetical 22.7 kD protein SC5H1.35c%2C 237 aa%3B fasta scores: opt: 456 z-score: 458.0 E(): 4.3e-18%3B 42.6%25 identity in 176 aa overlap. Contains possible N-terminal region signal peptide sequence~SCC61A.37c%2C possible hypothetical protein (fragment)%2C len: >114aa%3B forms to C-terminus of TR:CAB75305 (EMBL:AL139164) hypothetical protein on an overlapping cosmid. Contains possible hydrophobic membrane spanning region gene gene2726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2716 SCO2717 SCO2717 SCC46.02c SCC46.02c 2961104 2961331 - small membrane protein SCC46.02c%2C possible small membrane protein%2C len: 75 aa%3B similar to TR:Q9X9Z2 (EMBL:AL079332) Streptomyces coelicolor small hypothetical protein SCI5.08c%2C 82 aa%3B fasta scores: opt: 283 z-score: 339.8 E(): 1.6e-11%3B 58.1%25 identity in 74 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2717 SCO2718 SCO2718 SCC46.03c SCC46.03c 2961619 2962014 - hypothetical protein SCC46.03c%2C hypothetical protein%2C len: 131 aa%3B similar to S. coelicolor unknown protein SCC46.04%2C 147 aa%3B fasta scores: opt: 626 z-score: 635.3 E(): 6.2e-30%3B 69.2%25 identity in 130 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2718 SCO2719 SCO2719 SCC46.04 SCC46.04 2962235 2962678 + hypothetical protein SCC46.04%2C hypothetical protein%2C len: 147 aa%3B similar to S. coelicolor unknwon protein SCC46.03c%2C 131 aa%3B fasta scores: opt: 626 z-score: 650.1 E(): 9.3e-31%3B 69.2%25 identity in 130 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2719 SCO2720 SCO2720 SCC46.05c SCC46.05c 2962767 2964695 - long-chain fatty acid ligase SCC46.05c%2C possible long-chain fatty acid ligase%2C len: 642 aa%3B similar to TR:Q9ZBW6 (EMBL:AL034443) Streptomyces coelicolor long-chain-fatty-acid-CoA ligase SC4B5.02c%2C 608 aa%3B fasta scores: opt: 2039 z-score: 2214.0 E(): 0%3B 51.4%25 identity in 607 aa overlap and to SW:LCFB_HUMAN (EMBL:D10040) Homo sapiens long-chain-fatty-acid-CoA ligase 2 (EC 6.2.1.3) FacL2%2C 698 aa%3B fasta scores: opt: 471 z-score: 511.5 E(): 4.5e-21%3B 27.8%25 identity in 615 aa overlap. Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and match to Prosite entry PS00455 AMP-binding domain signature gene gene2730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2720 SCO2721 SCO2721 SCC46.06c SCC46.06c 2964860 2966458 - lipoprotein SCC46.06c%2C possible lipoprotein%2C len: 532 aa%3B similar to various hypothetical proteins%2C e.g. SW:YFBK_ECOLI (EMBL:AE000317) Escherichia coli hypothetical 63.6 kD protein in ElaD-NuoN intergenic region%2C YfbK%2C 575 aa%3B fasta scores: opt: 778 z-score: 815.2 E(): 0%3B 32.6%25 identity in 482 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene2731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2721 SCO2722 SCO2722 SCC46.07c SCC46.07c 2966690 2967589 - hypothetical protein SCC46.07c%2C possible integral membrane protein%2C len: 299 aa. Contains possible hydrophobic membrane spanning regions gene gene2732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2722 SCO2723 SCO2723 SCC46.08c SCC46.08c 2967586 2970186 - ABC transporter ATP-binding protein SCC46.08c%2C probable ABC transporter ATP-binding protein%2C len: 866 aa%3B C-terminal region similar to SW:YHCH_BACSU (EMBL:X96983) Bacillus subtilis hypothetical ABC transporter ATP-binding protein 2 in GlpD-CspB intergenic region%2C YhcH%2C 305 aa%3B fasta scores: opt: 597 z-score: 577.6 E(): 9.3e-25%3B 36.6%25 identity in 303 aa overlap and to SW:BCRA_BACLI (EMBL:L20573) Bacillus licheniformis bacitracin transport ATP-binding protein BcrA%2C 306 aa%3B fasta scores: opt: 581 z-score: 562.3 E(): 6.6e-24%3B 38.8%25 identity in 304 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Contains also possible N-terminal region signal peptide sequence gene gene2733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2723 SCO2724 SCO2724 SCC46.09c SCC46.09c 2970454 2971884 - amino acid transporter SCC46.09c%2C possible amino acid transporter%2C len: 476 aa%3B similar to TR:BAA87325 (EMBL:AB020520) Rattus norvegicus Y+L amino acid transporter 1%2C RT+Lat1%2C 512 aa%3B fasta scores: opt: 354 z-score: 394.6 E(): 1.5e-14%3B 26.3%25 identity in 460 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease. Contains also possible hydrophobic membrane spanning regions gene gene2734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2724 SCO2725 SCO2725 SCC46.10 SCC46.10 2972229 2973086 + lipoprotein SCC46.10%2C possible lipoprotein%2C len: 285 aa%3B identical to previously sequenced TR:Q53936 (EMBL:L48550) Streptomyces coelicolor unknown protein downstream of msdA. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal peptide sequence gene gene2735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2725 SCO2726 SCO2726 msdA msdA 2973144 2974646 - methylmalonic acid semialdehyde dehydrogenase SCC46.11c%2C msdA%2C methylmalonic acid semialdehyde dehydrogenase%2C 500 aa%3B identical to previously sequenced TR:Q53935 (EMBL:L48550) Streptomyces coelicolor methylmalonic acid semialdehyde dehydrogenase MsdA and highly similar to SW:MMSA_PSEAE (EMBL:M84911) Pseudomonas aeruginosa methylmalonate-semialdehyde dehydrogenase [acylating] (EC 1.2.1.27) MmsA%2C 496 aa%3B fasta scores: opt: 1652 z-score: 1799.5 E(): 0%3B 48.0%25 identity in 490 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family and match to Prosite entry PS00070 Aldehyde dehydrogenases cysteine active site gene gene2736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2726 SCO2727 SCO2727 SCC46.12c SCC46.12c 2974661 2975038 - hypothetical protein SCC46.12c%2C improbable CDS predicted by HMM%2C len: 125 aa gene gene2737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2727 SCO2728 SCO2728 SCC46.13 SCC46.13 2975219 2975617 + hypothetical protein SCC46.13%2C unknown%2C len: 132 aa gene gene2738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2728 SCO2729 SCO2729 SCC46.14 SCC46.14 2975704 2976312 + acetyltransferase SCC46.14%2C possible acetyltransferase%2C len: 202 aa%3B similar to SW:ATDA_ECOLI (EMBL:D25276) Escherichia coli spermidine N1-acetyltransferase (EC 2.3.1.57) SpeG%2C 185 aa%3B fasta scores: opt: 236 z-score: 303.2 E(): 1.8e-09%3B 27.6%25 identity in 170 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene2739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2729 SCO2730 SCO2730 SCC46.15 SCC46.15 2976325 2976630 + regulator SCC57A.01%2C possible regulator%2C partial CDS%2C len: > 47 aa. Similar to the C-terminus of Streptomyces coelicolor TR:CAB61163 (EMBL:AL132973) TetR-family transcriptional regulator (194 aa)%2C fasta scores opt: 85 z-score: 133.1 E():5 58.1%25 identity in 31 aa overlap.~SCC46.15%2C possible regulator (fragment)%2C len: >89 aa%3B N-terminal region of TR:CAB66269 (EMBL:AL136519) Streptomyces coelicolor regulator (fragment) SCC57A.01. gene gene2740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2730 SCO2731 SCO2731 SCC57A.02 SCC57A.02 2976666 2978948 + cation-transporting P-type ATPase SCC57A.02%2C probable cation transporting P-type ATPase%2C len: 760 aa. Highly similar to many cation transporters e.g. Mycobacterium leprae SW:CTPB_MYCLE(EMBL:Z46257) cation-transporting P-type ATPase B (EC 3.6.1.-) (750 aa)%2C fasta scores opt: 1955 z-score: 1929.1 E():0 49.5%25 identity in 750 aa overlap and Streptomyces coelicolor (EMBL:AL136149) SCM2.13c (762 aa)%2C fasta scores opt: 2552 z-score: 2109.2 E():0 55.8%25 identity in 749 aa overlap. Contains Prosite hits to PS00154 E1-E2 ATPases phosphorylation site%2C PS01229 Hypothetical cof family signature 2 and PS01047 Heavy-metal-associated domain. Also contains Pfam hits to PF00122 E1-E2_ATPase%2C E1-E2 ATPase and PF00403 HMA%2C Heavy-metal-associated domain%2C as well as%2C several possible membrane spanning hydrophobic domains. gene gene2741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2731 SCO2732 SCO2732 SCC57A.03c SCC57A.03c 2978987 2979586 - hypothetical protein SCC57A.03c%2C possible integral-membrane protein%2C len: 199 aa. Contains possible membrane spanning hydrophobic domains. gene gene2742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2732 SCO2733 SCO2733 SCC57A.04c SCC57A.04c 2979583 2980422 - hypothetical protein SCC57A.04c%2C unknown%2C len: 279 aa. Similar to several proteins of unconfirmed function including: Streptomyces coelicolor TR:CAB58282(EMBL:AL121850) conserved hypothetical protein SCC78.01C (fragment)%2C fasta scores opt: 274 z-score: 319.9 E(): 2e-10 35.3%25 identity in 235 aa overlap and Streptomyces nogalater TR:AAF01810(EMBL:AF187532) hydroxylase (275 aa)%2C fasta scores opt: 384 z-score: 443.4 E(): 2.6e-17 34.9%25 identity in 281 aa overlap. gene gene2743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2733 SCO2734 SCO2734 SCC57A.05 SCC57A.05 2980558 2981592 + LysR family transcriptional regulator SCC57A.05%2C possible LysR-family transcriptional regulator%2C len: 344 aa. Similar to several other regulators including: Streptomyces lividans TR:Q9X9S5 (EMBL:Y18818) transcriptional regulator (LysR-family)%2C found adjacent to the actinorhodin biosynthetic cluster (307 aa)%2C fasta scores opt: 275 z-score: 303.4 E(): 1.6e-09 31.3%25 identity in 336 aa overlap. Also similar to Streptomyces coelicolor regulators: TR:Q9X9U9 (EMBL:Y18817) transcriptional regulator of LysR family (307 aa)%2C fasta scores opt: 274 z-score: 302.6 E(): 1.8e-09 31.3%25 identity in 336 aa overlap and (EMBL:AL136058) LysR-family transcriptional regulator%2C SCE20.14 (297 aa)%2C fasta scores opt: 509 z-score: 460.1 E(): 3.3e-20 37.5%25 identity in 323 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins%2C lysR family signature and a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family with the helix-turn-helix motif situated between residues 16..37 (+2.63 SD). gene gene2744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2734 SCO2735 SCO2735 SCC57A.06 SCC57A.06 2981644 2982126 + hypothetical protein SCC57A.06%2C possible integral membrane protein%2C len: 160 aa. Similar to Streptomyces coelicolor TR:O69999(EMBL:AL022374) integral membrane protein SC5B8.13 (174 aa)%2C fasta scores opt: 186 z-score: 231.3 E(): 1.7e-05 34.5%25 identity in 148 aa overlap. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene2745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2735 SCO2736 SCO2736 gltA gltA 2982769 2984058 - type II citrate synthase type II enzyme%3B in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate%3B allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation%3B forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A%3B functions in TCA cycle%2C glyoxylate cycle and respiration%3B enzyme from Helicobacter pylori is not inhibited by NADH gene gene2746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2736 SCO2737 SCO2737 SCC57A.08c SCC57A.08c 2984296 2986557 - deoxyribonuclease SCC57A.08c%2C possible deoxyribonuclease%2C len: 753 aa. Similar to several including: Chlamydia trachomatis TR:O84036(EMBL:AE001278) exodeoxyribonuclease V%2C alpha subunit (746 aa)%2C fasta scores opt:1007 z-score: 1095.8 E():0 36.8%25 identity in 740 aa overlap and to the C-terminus of Escherichia coli SW:EX5A_ECOLI(EMBL:X04582) exodeoxyribonuclease V (EC 3.1.11.5) RecD (608 aa)%2C fasta scores opt: 225 z-score: 245.0 E(): 2.9e-06 29.3%25 identity in 460 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene2747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2737 SCO2738 SCO2738 SCC57A.09c SCC57A.09c 2986705 2986902 - hypothetical protein SCC57A.09c%2C unknown%2C len: 65 aa. Highly similar to many other Streptomyces coelicolor proteins of undefined function e.g. TR:Q9XD97(EMBL:AF106004) (63 aa)%2C fasta scores opt: 197 z-score: 305.4 E(): 1.3e-09 47.5%25 identity in 59 aa overlap and TR:CAB62714(EMBL:AL133423) SC4A7.10 (65 aa)%2C fasta scores opt: 156 z-score: 245.9 E(): 2.6e-06 45.5%25 identity in 55 aa overlap. This gene is duplicated on this cosmid and shares 62.9%25 identity%2C in a 62 aa overlap%2C with the adjoining CDS SCC57A.10c. Note codon 4 may offer an alternative translational start site. gene gene2748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2738 SCO2739 SCO2739 SCC57A.10c SCC57A.10c 2986899 2987096 - hypothetical protein SCC57A.10c%2C unknown%2C len: 65 aa. Highly similar to many other Streptomyces coelicolor proteins of undefined function e.g. TR:Q9XD97(EMBL:AF106004) (63 aa)%2C fasta scores opt: 237 z-score: 360.2 E(): 1.1e-12 64.8%25 identity in 54 aa overlap and TR:Q9Z544(EMBL:AL035212) SC9B2.15C (77 aa)%2C fasta scores opt: 145 z-score: 227.3 E(): 2.9e-05 51.0%25 identity in 49 aa overlap. This gene is duplicated on this cosmid and shares 62.9%25 identity%2C in a 62 aa overlap%2C with the adjoining CDS SCC57A.09c. Note codon 4 may offer an alternative translational start site. gene gene2749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2739 SCO2740 SCO2740 SCC57A.11 SCC57A.11 2987168 2987528 + gene gene2750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2740 SCO2741 SCO2741 SCC57A.12 SCC57A.12 2987625 2988134 + hypothetical protein SCC57A.12%2C possible hypothetical protein%2C len: 169 aa. Contains a possible N-terminal signal sequence. gene gene2751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2741 SCO2742 SCO2742 SCC57A.13c SCC57A.13c 2988198 2989145 - sigma factor SCC57A.13c%2C possible sigma factor%2C len: 315 aa. Similar to many Streptomyces coelicolor ECF sigma factors e.g. TR:CAB53126 (EMBL:AL109962) SCJ1.08 (322 aa)%2C fasta scores opt: 506 z-score: 595.6 E(): 8.7e-26 34.5%25 identity in 290 aa overlap. Also similar to Mycobacterium tuberculosis TR:O53378 (EMBL:AL021841) sigma factor (fragment)(312 aa)%2C fasta scores opt: 525 z-score: 617.9 E(): 5e-27 33.7%25 identity in 291 aa overlap. Contains a helix-turn-helix motif situated between residues 152..173 (+2.66 SD). gene gene2752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2742 SCO2743 SCO2743 SCC57A.14 SCC57A.14 2989276 2989761 + hypothetical protein SCC57A.14%2C hypothetical protein%2C len: 161 aa%3B similar to TR:Q9FC57 (EMBL:AL391515) Streptomyces coelicolor conserved hypothetical protein SC4B10.30c%2C 156 aa%3B fasta scores: opt: 624 Z-score: 777.1 E(): 1.2e-35%3B 60.897%25 identity in 156 aa overlap gene gene2753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2743 SCO2744 SCO2744 SCC57A.15c SCC57A.15c 2989772 2990122 - hypothetical protein SCC57A.15c%2C unknown%2C len: 116 aa. gene gene2754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2744 SCO2745 SCO2745 SCC57A.16 SCC57A.16 2990408 2991451 + LacI family transcriptional regulator SCC57A.16%2C probable LacI-family transcriptional regulator%2C len: 347 aa. Highly similar to many other regulators including: Escherichia coli SW:CYTR_ECOLI (EMBL:X03683) transcriptional repressor CytR (341 aa)%2C fasta scores opt: 714 z-score: 751.4 E(): 0 34.9%25 identity in 332 aa overlap and Streptomyces coelicolor TR:Q9Z509 (EMBL:AL035591) transcriptional regulator SCC54.16 (368 aa)%2C fasta scores opt: 843 z-score: 885.1 E():0 43.4%25 identity in 348 aa overlap. Contains a Prosite hit to PS00356 Bacterial regulatory proteins%2C lacI family signature and Pfam hits to PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family. The possible helix-turn-helix motif is situated between residues 2..23 (+5.89 SD). gene gene2755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2745 SCO2746 SCO2746 SCC57A.17 SCC57A.17 2991448 2993001 + ABC transporter ATP-binding protein SCC57A.17%2C ABC transporter%2C ATP binding component%2C len: 517 aa. Highly similar to many including: Escherichia coli SW:RBSA_ECOLI(EMBL:M13169) ribose transport ATP-binding protein RbsA (501 aa)%2C fasta scores opt: 1421 z-score: 1446.1 E(): 0 47.5%25 identity in 493 aa overlap and Streptomyces coelicolor TR:O69942(EMBL:AL023862) ABC transporter ATP binding protein SC3F9.02 (505 aa)%2C fasta scores opt: 1495 z-score: 1521.0 E(): 0 50.2%25 identity in 494 aa overlap. Contains Prosite hits to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains 2x Pfam matches to entry PF00005 ABC_tran%2C ABC transporter. gene gene2756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2746 SCO2747 SCO2747 SCC57A.18 SCC57A.18 2992991 2994946 + bifunctional carbohydrate binding and transport protein SCC57A.18%2C bifunctional carbohydrate binding and transport protein%2C len: 613 aa. The N-terminus is highly similar to many ribose transport system permeases e.g. Escherichia coli SW:RBSC_ECOLI(EMBL:L10328) ribose transport system permease RbsC (321 aa)%2C fasta scores opt: 846 z-score: 833.8 E(): 0 47.1%25 identity in 310 aa overlap. The C-terminus is highly similar to many ribose-binding proteins e.g. Escherichia coli SW:RBSB_ECOLI(EMBL:K00511) D-ribose-binding periplasmic protein precursor (296 aa)%2C fasta scores opt: 863 z-score: 847.0 E():0 46.9%25 identity in 303 aa overlap. Contains a Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family. The N-terminus contains multiple possible membrane spanning hydrophobic domains. gene gene2757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2747 SCO2748 SCO2748 SCC57A.19 SCC57A.19 2994994 2995914 + carbohydrate kinase SCC57A.19%2C carbohydrate kinase%2C len: 306 aa. Highly similar to several ribokinases including: Escherichia coli SW:RBSK_ECOLI (EMBL:M13169) ribokinase (EC 2.7.1.15) (309aa)%2C fasta scores opt: 602 z-score: 638.1 E(): 3.7e-28 40.5%25 identity in 299 aa overlap and Bacillus subtilis SW:RBSK_BACSU (EMBL:Z25798) ribokinase (EC 2.7.1.15) (293 aa)%2C fasta scores opt: 639 z-score: 677.0 E(): 2.5e-30 41.1%25 identity in 299 aa overlap. Contains Prosite hits to PS00583 pfkB family of carbohydrate kinases signature 1 and PS00584 pfkB family of carbohydrate kinases signature 2. Also contains a Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase. gene gene2758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2748 SCO2749 SCO2749 SCC57A.20 SCC57A.20 2995911 2996300 + D-ribose pyranase cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose%3B RbsD is required for efficient ribose utilization in E. coli%3B rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source gene gene2759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2749 SCO2750 SCO2750 SCC57A.21c SCC57A.21c 2996489 2997352 - hypothetical protein SCC57A.21c%2C hypothetical protein%2C len: 287 aa%3B similar to TR:CAC41509 (EMBL:AL591782) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMC04130%2C 274 aa%3B fasta scores: opt: 796 Z-score: 889.6 E(): 6.4e-42%3B 47.191%25 identity in 267 aa overlap gene gene2760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2750 SCO2751 SCO2751 SCC57A.22c SCC57A.22c 2997349 2998515 - hypothetical protein SCC57A.22c%2C unknown%2C len: 388 aa. gene gene2761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2751 SCO2752 SCO2752 SCC57A.23c SCC57A.23c 2998512 2999648 - oxidoreductase SCC57A.23c%2C possible oxidoreductase%2C len: 378 aa. Weakly similar to several other oxidoreductases e.g. Streptomyces coelicolor TR:O69945 (EMBL:AL023862) oxidoreductase (430 aa)%2C fasta scores opt: 252 z-score: 300.4 E(): 2.4e-09 28.8%25 identity in 278 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene2762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2752 SCO2753 SCO2753 SCC57A.24 SCC57A.24 2999879 3000925 + LacI family transcriptional regulator SCC57A.24%2C possible LacI-family transcriptional regulator%2C len: 348 aa. Similar to many other Streptomyces coelicolor LacI-family regulators including: TR:Q9X862 (EMBL:AL049661) SCE134.07 (353 aa)%2C fasta scores opt: 489 z-score: 554.3 E(): 1.8e-23 33.8%25 identity in 358 aa overlap and TR:O86795 (EMBL:AL031317) SC6G4.32 (355 aa)%2C fasta scores opt: 460 z-score: 521.7 E(): 1.2e-21 37.1%25 identity in 353 aa overlap. Contains a Prosite hit to PS00356 Bacterial regulatory proteins%2C lacI family signature and Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family. A helix-turn-helix motif is situated between residues 3..24 (+5.80 SD). gene gene2763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2753 SCO2754 SCO2754 SCC57A.25 SCC57A.25 3001125 3001931 + hypothetical protein SCC57A.25%2C unknown%2C len: 268 aa. Weakly similar to Streptomyces coelicolor TR:Q9Z596(EMBL:AL035478) oxidoreductase (279 aa)%2C fasta scores opt: 185 z-score: 212.6 E(): 0.00019 29.6%25 identity in 247 aa overlap. gene gene2764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2754 SCO2755 SCO2755 SCC57A.26c SCC57A.26c 3001915 3002577 - acetyltransferase SCC57A.26c%2C possible acetyltransferase%2C len: 220 aa. Weakly similar to Deinococcus radiodurans TR:AAF10183 (EMBL:AE001918) acetyltransferase (188 aa)%2C fasta scores opt: 308 z-score: 385.7 E(): 4.3e-14 37.0%25 identity in 189 aa overlap and Myxococcus xanthus TR:O54394 (EMBL:U81516) hypothetical 24.4 KD protein (216 aa)%2C fasta scores opt: 453 z-score: 561.2 E(): 7.2e-24 46.6%25 identity in 206 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene2765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2755 SCO2756 SCO2756 SCC57A.27c SCC57A.27c 3002574 3003509 - hypothetical protein SCC57A.27c%2C integral membrane protein%2C len: 311 aa. Similar to many proteins of undefined function including: Deinococcus radiodurans TR:AAF09725(EMBL:AE001876) conserved hypothetical protein (325 aa)%2C fasta scores opt: 713 z-score: 803.2 E(): 0 41.8%25 identity in 280 aa overlap and Bacillus subtilis SW:YOAV_BACSU(EMBL:AF027868) hypothetical 33.0 KD protein (292 aa)%2C fasta scores opt: 355 z-score: 404.7 E(): 3.8e-15 26.3%25 identity in 297 aa overlap. Contains 2xPfam matches to entry PF00892 DUF6%2C Integral membrane protein. gene gene2766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2756 SCO2757 SCO2757 SCC57A.28 SCC57A.28 3003658 3004599 + LysR family transcriptional regulator SCC57A.28%2C possible LysR-family transcriptional regulator%2C len: 313 aa. Similar to several other regulators including: Escherichia coli SW:XAPR_ECOLI (EMBL:X63976) xanthosine operon regulatory protein (294 aa)%2C fasta scores opt: 322 z-score: 366.5 E(): 5e-13 27.4%25 identity in 292 aa overlap. Also similar to several other Streptomyces coelicolor regulators including: TR:O86805 (EMBL:AL031317) SC6G4.44 (306 aa)%2C fasta scores opt: 523 z-score: 590.0 E(): 1.8e-25 37.2%25 identity in 320 aa overlap and TR:CAB62680 (EMBL:AL133422) SCM1.22C (301 aa)%2C fasta scores opt: 636 z-score: 715.9 E(): 1.8e-32 41.5%25 identity in 294 aa overlap. Contains a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family%2C with the helix-turn-helix motif situated between residues 17..38 (+4.21 SD). gene gene2767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2757 SCO2758 SCO2758 nagA nagA 3004794 3006641 + beta-N-acetylglucosaminidase SCC57A.29%2C nagA%2C beta-N-acetylglucosaminidase ( hypothetical protein)%2C len: 615 aa%2C Highly similar to Streptomyces thermoviolaceus TR:O82840 (EMBL:AB008771) beta-N-acetylglucosaminidase precursor (EC 3.2.1.30) (632 aa)%2C fasta scores opt: 3169 z-score: 3414.1 E():0 80.0%25 identity in 614 aa overlap. Note the N-terminus of the S. coelicolor protein varies significantly from that of the S. thermoviolaceus protein. Contains a Prosite hit to PS00775 Glycosyl hydrolases family 3 active site and a Pfam match to entry PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3. Also contains a possible N-terminal region signal peptide sequence gene gene2768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2758 SCO2759 SCO2759 SCC57A.30c SCC57A.30c 3006815 3008032 - transposase SCC57A.30c%2C probable IS110 transposase%2C len: 405 aa. Previously sequenced SW:YIS1_STRCO(EMBL:Y00434) hypothetical protein within the Streptomyces coelicolor insertion element IS110. Contains a Pfam match to entry PF01548 Transposase_9%2C Transposase. Also highly similar to the Streptomyces coelicolor insertion element fragments: TR:O69926(EMBL:AL023861) SC3C8.13 (>175 aa)%2C fasta scores opt: 804 z-score: 907.9 E():0 71.3%25 identity in 171 aa overlap and TR:O69929(EMBL:AL023861) SC3C8.17 (>230 aa)%2C fasta scores opt: 1023 z-score: 1150.6 E(): 0 69.1%25 identity in 230 aa overlap. gene gene2769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2759 SCO2760 SCO2760 SCC57A.31 SCC57A.31 3008299 3008949 + hypothetical protein SCC57A.31%2C possible membrane protein%2C len: 216 aa. Contains a possible membrane spanning hydrophobic domain. gene gene2770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2760 SCO2761 SCO2761 SCC57A.32c SCC57A.32c 3008987 3010411 - tripeptidyl aminopeptidase SCC57A.32c%2C possible tripeptidyl aminopeptidase%2C len: 474 aa. Identical to Streptomyces lividans TR:Q54408(EMBL:L46588) tripeptidyl aminopeptidase precursor (474 aa)%2C fasta scores opt: 3236 z-score: 3793.9 E(): 0%3B 99.6%25 identity in 474 aa overlap. Contains a possible N-terminal signal sequence. gene gene2771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2761 SCO2762 SCO2762 SCC57A.33c SCC57A.33c 3010475 3010867 - hypothetical protein SCC57A.33c%2C possible hypothetical protein%2C len: 130 aa. Similar to Streptomyces coelicolor TR:CAB59706(EMBL:AL132707) spore-associated protein precursor (154 aa)%2C fasta scores opt: 113 z-score: 146.1 E(): 0.95 30.6%25 identity in 121 aa overlap. Contains a possible N-terminal signal sequence. gene gene2772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2762 SCO2763 SCO2763 SCC57A.34c SCC57A.34c 3010977 3014708 - ABC transporter ATP-binding protein SCC57A.34c%2C ABC transporter%2C ATP-binding component%2C len: 1253 aa. Highly similar to many Prokaryotic and Eukaryotic transport proteins including: Mycobacterium tuberculosis TR:O53645(EMBL:AL021928) ABC transporter (1194 aa)%2C fasta scores opt: 2002 z-score: 2049.7 E():0 53.0%25 identity in 1231 aa overlap and Drosophila melanogaster SW:MDR4_DROME(EMBL:M59076) multidrug resistance protein homolog 50 (P-glycoprotein 50) (1302 aa)%2C fasta scores opt: 1550 z-score: 1585.8 E():0 30.7%25 identity in 1267 aa overlap. Contains Prosite hits to 2x PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains Pfam matches to entries 2x PF00664 ABC_membrane%2C ABC transporter transmembrane region%2C 2x Pfam match to entry PF00005 ABC_tran%2C ABC transporter and multiple possible membrane spanning hydrophobic domains. gene gene2773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2763 SCO2764 SCO2764 SCC57A.35c SCC57A.35c 3014808 3015818 - lipoprotein SCC57A.35c%2C possible lipoprotein%2C len: 336 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene2774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2764 SCO2765 SCO2765 SCC57A.36 SCC57A.36 3015897 3016268 + hypothetical protein SCC57A.36%2C unknown%2C len: 123 aa. gene gene2775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2765 SCO2766 SCO2766 SCC57A.37 SCC57A.37 3016395 3017255 + ribonuclease SCC57A.37%2C possible ribonuclease%2C len: 286 aa. Highly similar to Bacillus subtilis SW:RN_BACSU (EMBL:D01097) ribonuclease precursor (EC 3.1.-.-) (289 aa)%2C fasta scores opt: 1165 z-score: 1237.7 E():0 61.5%25 identity in 273 aa overlap. Contains a possible N-terminal signal sequence rich in the amino acid Ala. gene gene2776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2766 SCO2767 SCO2767 SCC57A.38c SCC57A.38c 3017260 3019491 - ATP/GTP-binding protein SCC57A.38c%2C possible ATP/GTP-binding protein%2C len: 743 aa. Weakly similar to another Streptomyces coelicolor TR:O86768(EMBL:AL031035) ATP/GTP-binding protein (886 aa)%2C fasta scores opt: 328 z-score: 356.5 E(): 1.8e-12 28.9%25 identity in 699 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene2777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2767 SCO2768 SCO2768 SCC57A.39c SCC57A.39c 3019488 3019907 - hypothetical protein SCC57A.39c%2C unknown%2C len: 139 aa. gene gene2778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2768 SCO2769 SCO2769 SCC57A.40c SCC57A.40c 3019967 3021661 - acetolactate synthase SCC57A.40c%2C possible acetolactate synthase%2C len: 564 aa. Similar to many e.g. Escherichia coli SW:ILVB_ECOLI (EMBL:J01633) acetolactate synthase isozyme I large subunit (EC 4.1.3.18) (562 aa)%2C fasta scores opt: 732 z-score: 776.9 E(): 0 29.6%25 identity in 538 aa overlap. Contains a Prosite hit to PS00187 Thiamine pyrophosphate enzymes signature and a Pfam match to entry PF00205 TPP_enzymes%2C Thiamine pyrophosphate enzymes gene gene2779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2769 SCO2770 SCO2770 SCC105.01c SCC105.01c 3021658 3022626 - agmatinase SCC105.01c%2C speB%2C agmatinase (fragment)%2C len: >302 aa%3B highly similar to N-terminal region of SW:SPEB_STRCL (EMBL:L15470) Streptomyces clavuligerus possible agmatinase (EC 3.5.3.11) Pah%2C 313 aa%3B fasta scores: opt: 843 z-score: 968.6 E(): 0%3B 43.3%25 identity in 293 aa overlap and of SW:SPEB_ECOLI (EMBL:M32363) Escherichia coli agmatinase (EC 3.5.3.11)%2C SpeB%2C 306 aa%3B fasta scores: opt: 473 z-score: 546.7 E(): 5.1e-23%3B 41.8%25 identity in 282 aa overlap. Contains Pfam match to entry PF00491 arginase%2C Arginase family and matches to Prosite entries PS00147 Arginase family signature 1%2C PS00148 Arginase family signature 2%2C PS00678 Trp-Asp (WD) repeats signature and PS01053 Arginase family signature 3~SCC57A.41c%2C possible agmatinase%2C partial CDS%2C len: >53 aa. Highly similar to Escherichia coli SW:SPEB_ECOLI(EMBL:M32363) agmatinase (EC 3.5.3.11) (306 aa)%2C fasta scores opt: 145 z-score: 242.9 E(): 3.8e-06 49.0%25 identity in 49 aa overlap and Schizosaccharomyces pombe SW:SPEB_SCHPO(EMBL:Z68166) agmatinase precursor (EC 3.5.3.11) (394 aa)%2C fasta scores opt: 159 z-score: 263.7 E(): 2.7e-07 55.6%25 identity in 45 aa overlap. gene gene2780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2770 SCO2771 SCO2771 SCC105.02 SCC105.02 3022836 3023624 + hypothetical protein SCC105.02%2C hypothetical protein%2C len: 262 aa%3B similar to TR:Q9WX05 (EMBL:AL079345) Streptomyces coelicolor hypothetical 28.5 kD protein SCE68.27c%2C 271 aa%3B fasta scores: opt: 315 z-score: 382.9 E(): 6.8e-14%3B 42.8%25 identity in 269 aa overlap gene gene2781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2771 SCO2772 SCO2772 SCC105.03c SCC105.03c 3023634 3024614 - membrane transport protein SCC105.03c%2C possible membrane transport protein%2C len: 326 aa%3B similar to TR:O85699 (EMBL:AF072709) Streptomyces lividans hypothetical 35.5 kD protein%2C 338 aa%3B fasta scores: opt: 702 z-score: 839.7 E(): 0%3B 41.7%25 identity in 324 aa overlap. Contains Pfam match to entry PF01545 Cation_efflux%2C Cation efflux family and match to Prosite entry PS01156 TonB-dependent receptor proteins signature 2. Contains also possible hydrophobic membrane spanning regions gene gene2782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2772 SCO2773 SCO2773 SCC105.04c SCC105.04c 3024620 3025492 - acyl-CoA thioesterase II SCC105.04c%2C tesB2%2C acyl CoA thioesterase II%2C len: 290 aa%3B highly similar to SW:TESB_ECOLI (EMBL:M63308) Escherichia coli acyl CoA thioesterase II TesB%2C 285 aa%3B fasta scores: opt: 877 z-score: 1015.0 E(): 0%3B 48.6%25 identity in 286 aa overlap gene gene2783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2773 SCO2774 SCO2774 acdH2 acdH2 3025503 3026660 - acyl-CoA dehydrogenase SCC105.05c%2C acdH2%2C probable acyl-CoA dehydrogenase%2C len: 385 aa%3B similar to TR:Q9X7Y2 (EMBL:AL049485) Streptomyces coelicolor probable acyl-CoA dehydrogenase SC6A5.36%2C 382 aa%3B fasta scores: opt: 1170 z-score: 1351.4 E(): 0%3B 47.9%25 identity in 382 aa overlap. Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and match to Prosite entry PS00073 Acyl-CoA dehydrogenases signature 2 gene gene2784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2774 SCO2775 SCO2775 SCC105.06c SCC105.06c 3026790 3027416 - TetR family transcriptional regulator SCC105.06%2C possible tetR-family regulatory protein%2C len: 208 aa%3B similar to TR:AAF11696 (EMBL:AE002049) Deinococcus radiodurans transcriptional regulatory protein%2C tetR family DR2148%2C 240 aa%3B fasta scores: opt: 189 z-score: 219.0 E(): 9.3e-05%3B 31.7%25 identity in 205 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene2785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2775 SCO2776 SCO2776 accD1 accD1 3027514 3029130 + acetyl/propionyl CoA carboxylase subunit beta SCC105.07%2C accD1%2C acetyl/propionyl CoA carboxylase%2C beta subunit%2C len: 538 aa%3B similar to TR:O06165 (EMBL:Z95556) Mycobacterium tuberculosis%2C hypothetical 56.7 kD protein MTCY07A7.08c%2C 529 aa%3B fasta scores: opt: 2749 z-score: 3110.3 E(): 0%3B 76.5%25 identity in 532 aa overlap and to TR:AAF35258 (EMBL:AF059510) Arabidopsis thaliana 3-methylcrotonyl-CoA carboxylase non-biotinylated subunit (EC 6.4.1.4) MccB%2C 587 aa%3B fasta scores: opt: 2185 z-score: 2471.8 E(): 0%3B 60.4%25 identity in 540 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans%2C Carboxyl transferase domain gene gene2786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2776 SCO2777 SCO2777 accC accC 3029169 3031109 + acetyl/propionyl CoA carboxylase subunit alpha SCC105.08%2C accC%2C acetyl/propionyl CoA carboxylase alpha subunit%2C len: 646 aa%3B similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA%2C 703 aa%3B fasta scores: opt: 1539 z-score: 1630.1 E(): 0%3B 43.0%25 identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14)%2C alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG%2C 449 aa%3B fasta scores: opt: 1439 z-score: 1527.1 E(): 0%3B 47.9%25 identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptomyces coelicolor pyruvate carboxylase SCF11.26c%2C 1124 aa%3B fasta scores: opt: 1367 z-score: 1204.5 E(): 0%3B 44.3%25 identity in 569 aa overlap. Contains Pfam matches to entries PF00289 CPSase_L_chain%2C Carbamoyl-phosphate synthase (CPSase) and Pfam match to entry PF00364 biotin_lipoyl%2C Biotin-requiring enzymes and matches to Prosite entries PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site gene gene2787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2777 SCO2778 SCO2778 hmgL hmgL 3031106 3032059 + hydroxymethylglutaryl-CoA lyase SCC105.09%2C hmgL%2C hydroxymethylglutaryl-CoA lyase%2C len: 317 aa%3B similar to TR:P95639 (EMBL:U41280) Rhodospirillum rubrum hydroxymethylglutaryl-CoA lyase (EC4.1.3.4) HmgL%2C 303 aa%3B fasta scores: opt: 924 z-score: 1043.1 E(): 0%3B 51.2%25 identity in 297 aa overlap and to SW:HMGL_RAT (EMBL:Y10054) Rattus norvegicus hydroxymethylglutaryl-CoA lyase%2C mitochondrial precursor (EC 4.1.3.4) HmgCL%2C 325 aa%3B fasta scores: opt: 983 z-score: 1108.8 E(): 0%3B 52.7%25 identity in 296 aa overlap. Contains Pfam match to entry PF00682 HMGL-like%2C HMGL-like gene gene2788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2778 SCO2779 SCO2779 acdH acdH 3032065 3033225 + acyl-CoA dehydrogenase SCC105.10%2C acdH%2C acyl-CoA dehydrogenase%2C len: 386 aa%3B identical to previously sequenced TR:Q9XCG6 (EMBL:AF142581) Streptomyces coelicolor acyl-CoA dehydrogenase AcdH%2C 386 aa. Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and matches to Prosite entries PS00072 Acyl-CoA dehydrogenases signature 1 and PS00073 Acyl-CoA dehydrogenases signature 2 gene gene2789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2779 SCO2780 SCO2780 SCC105.11 SCC105.11 3033355 3034404 + hypothetical protein SCC105.11%2C possible hypothetical protein%2C len: 349 aa%3B similar to TR:CAB53324 (EMBL:AL109974) Streptomyces coelicolor iron-siderophore binding lipoprotein SCF34.13c%2C 350 aa%3B fasta scores: opt: 288 z-score: 297.2 E(): 4.1e-09%3B 28.3%25 identity in 332 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2780 SCO2781 SCO2781 SCC105.12 SCC105.12 3034632 3035477 + hypothetical protein SCC105.12%2C hypothetical protein%2C len: 281 aa%3B similar to TR:CAB56689 (EMBL:AL121596) Streptomyces coelicolor hypothetical 28.7 kD protein%2C 259 aa%3B fasta scores: opt: 261 z-score: 302.6 E(): 2e-09%3B 34.9%25 identity in 255 aa overlap gene gene2791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2781 SCO2782 SCO2782 SCC105.13 SCC105.13 3035641 3037083 + pyridoxal-dependent decarboxylase SCC105.13%2C probable pyridoxal-dependent decarboxylase%2C len: 480 aa%3B similar to SW:RHSB_RHIME (EMBL:AF110737) Rhizobium meliloti L-2%2C4-diaminobutyrate decarboxylase (EC 4.1.1.-) RhsB%2C 495 aa%3B fasta scores: opt: 1111 z-score: 1326.2 E(): 0%3B 41.9%25 identity in 458 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC%2C Pyridoxal-dependent decarboxylase conserved domain gene gene2792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2782 SCO2783 SCO2783 SCC105.14 SCC105.14 3037106 3038347 + monooxygenase SCC105.14%2C probable monooxygenase%2C len: 413 aa%3B similar to SW:RHSE_RHIME (EMBL:AF110737) Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsE (EC 1.-.-.-)%2C 454 aa%3B fasta scores: opt: 616 z-score: 727.2 E(): 0%3B 42.3%25 identity in 430 aa overlap and to SW:IUCD_ECOLI (EMBL:M18968) Escherichia coli L-lysine 6-monooxygenase (EC 1.13.12.10) IucD%2C 425 aa%3B fasta scores: opt: 802 z-score: 946.5 E(): 0%3B 31.6%25 identity in 414 aa overlap gene gene2793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2783 SCO2784 SCO2784 SCC105.15 SCC105.15 3038344 3038898 + aceytltranferase SCC105.15%2C probable aceytltranferase%2C len: 184 aa%3B similar to SW:RHSD_RHIME (EMBL:AF110737) Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsD%2C 196 aa%3B fasta scores: opt: 257 z-score: 326.7 E(): 9.2e-11%3B 33.7%25 identity in 172 aa overlap and to TR:AAD46626 (EMBL:AF162771) Pseudomonas aeruginosa aminoglycoside 6'-N-acetyltransferase Aac%2C 193 aa%3B fasta scores: opt: 175 z-score: 226.3 E(): 3.6e-05%3B 28.2%25 identity in 174 aa overlap gene gene2794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2784 SCO2785 SCO2785 SCC105.16 SCC105.16 3038895 3040682 + hypothetical protein SCC105.16%2C hypothetical protein%2C len: 595 aa%3B similar to SW:RHSF_RHIME (EMBL:AF110737) Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhsF%2C 601 aa%3B fasta scores: opt: 1094 z-score: 1325.6 E(): 0%3B 32.4%25 identity in 592 aa overlap and to TR:P94255 (EMBL:U61153) Bordetella bronchiseptica AlcC%2C 618 aa%3B fasta scores: opt: 2037 z-score: 2470.2 E(): 0%3B 51.5%25 identity in 592 aa overlap gene gene2795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2785 SCO2786 SCO2786 hexA hexA 3040752 3042359 - beta-N-acetylhexosaminidase SCC105.17c%2C hexA%2C beta-N-acetylhexosaminidase precursor%2C len: 535 aa%3B highly similar to TR:O85361 (EMBL:AF063001) Streptomyces plicatus B-N-acetylhexosaminidase%2C Hex%2C 561 aa%3B fasta scores: opt: 2991 z-score: 3318.1 E(): 0%3B 93.2%25 identity in 469 aa overlap and to TR:BAA8876 (EMBL:AB015350) Streptomyces thermoviolaceus beta-N-acetylglucosaminidase precursor NagB%2C 541 aa%3B fasta scores: opt: 2856 z-score: 3168.6 E(): 0%3B 76.7%25 identity in 537 aa overlap. Contains Pfam match to entry PF00728 Glyco_hydro_20%2C Glycosyl hydrolase family 20 and possible N-terminal region signal peptide sequence gene gene2796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2786 SCO2787 SCO2787 SCC105.18 SCC105.18 3042474 3043370 + hypothetical protein SCC105.18%2C hypothetical protein%2C len: 298 aa%3B similar to TR:Q9RDQ8 (EMBL:AL133423) Streptomyces coelicolor hypothetical 31.7 kD protein SC4A7.04%2C 295 aa%3B fasta scores: opt: 556 z-score: 623.0 E(): 2.9e-27%3B 37.4%25 identity in 294 aa overlap gene gene2797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2787 SCO2788 SCO2788 SCC105.19 SCC105.19 3043459 3043716 + hypothetical protein SCC105.19%2C unknown%2C len: 85 aa gene gene2798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2788 SCO2789 SCO2789 glmS2 glmS2 3043786 3045603 + glucosamine-fructose-6-phosphate aminotransferase SCC105.20%2C glmS2%2C glucosamine-fructose-6-phosphate aminotransferase%2C len: 605 aa%3B similar to SW:GLMS_ECOLI (EMBL:X01631) Escherichia coli glucosamine-fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) GlmS%2C 608 aa%3B fasta scores: opt: 1617 z-score: 1815.6 E(): 0%3B 44.1%25 identity in 612 aa overlap and highly similar to TR:BAA86263 (EMBL:AB023785) Streptomyces griseus ORF3 (fragment)%2C 589 aa%3B fasta scores: opt: 3364 z-score: 3776.2 E(): 0%3B 87.6%25 identity in 589 aa overlap and also to SW:GLMS_STRCO (EMBL:AL031317) Streptomyces coelicolor GlmS1%2C probable glucosamine--fructose-6-phosphate aminotransferase SC6G4.18%2C 615 aa%3B fasta scores: opt: 1480 z-score: 1526.7 E(): 0%3B 43.8%25 identity in 621 aa overlap. Contains Pfam matches to entries PF00310 GATase_2%2C Glutamine amidotransferases class-II and 2x PF01380 SIS%2C SIS domain gene gene2799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2789 SCO2790 SCO2790 SCC105.21c SCC105.21c 3045619 3046146 - hypothetical protein SCC105.21c%2C hypothetical protein%2C len: 175 aa%3B highly similar to TR:BAA86264 (EMBL:AB023785) Streptomyces griseus ORF2%2C 173 aa%3B fasta scores: opt: 998 z-score: 1157.6 E(): 0%3B 82.9%25 identity in 175 aa overlap gene gene2800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2790 SCO2791 SCO2791 SCC105.22c SCC105.22c 3046452 3046763 - hypothetical protein SCC105.22c%2C unknown%2C len: 103 aa gene gene2801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2791 SCO2792 SCO2792 adpA adpA 3047135 3048331 + AraC family transcription regulator SCC105.23%2C adpA%2C araC-family transcriptional regulator%2C len: 398 aa%3B highly similar to TR:BAA86265 (EMBL:AB023785) Streptomyces griseus AdpA%2C 405 aa%3B fasta scores: opt: 2219 z-score: 2270.5 E(): 0%3B 84.4%25 identity in 410 aa overlap and to TR:Q9XA73 (EMBL:AL096822) Streptomyces coelicolor araC-family transcriptional regulator SCGD3.05%2C 334 aa%3B fasta scores: opt: 878 z-score: 904.2 E(): 0%3B 45.7%25 identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and match to Prosite entry PS00041 Bacterial regulatory proteins%2C araC family signature. Contains possible helix-turn-helix motif gene gene2802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2792 SCO2793 SCO2793 2SCC13.01 2SCC13.01 3048673 3049275 + oligoribonuclease 3'-5' exoribonuclease specific for small oligoribonuclotides gene gene2803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2793 SCO2794 SCO2794 2SCC13.02c 2SCC13.02c 3049837 3050892 - LacI family transcriptional regulator 2SCC13.02c%2C lacI-family transcriptional regulatory protein%2C len: 351 aa%3B highly similar to TR:Q9X9R3 (EMBL:AJ009798) Streptomyces reticuli CebR protein%2C 350 aa%3B fasta scores: opt: 2011 z-score: 2174.4 E(): 0%3B 89.4%25 identity in 350 aa overlap and C-terminal region identical to TR:BAB03462 (EMBL:AB036424) Streptomyces coelicolor transcriptional regulator (fragment) ORF5-H%2C 193 aa. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Also contains a possible helix-turn-helix motif at residues 14..35 (+6.05 SD) gene gene2805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2794 SCO2795 SCO2795 2SCC13.03 2SCC13.03 3051258 3052583 + sugar binding hypothetical protein 2SCC13.03%2C probable sugar binding hypothetical protein%2C len: 441 aa%3B highly similar to TR:Q9X9R7 (EMBL:AJ009797) Streptomyces reticuli Cbp protein precursor (fragment) CebE%2C 444 aa%3B fasta scores: opt: 1490 z-score: 1672.5 E(): 0%3B 51.2%25 identity in 445 aa overlap and similar to SW:LACE_AGRRD (EMBL:X66596) Agrobacterium radiobacter Lactose-binding protein precursor LacE%2C 422 aa%3B fasta scores: opt: 263 z-score: 298.4 E(): 4.1e-09%3B 23.1%25 identity in 398 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene2806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2795 SCO2796 SCO2796 2SCC13.04 2SCC13.04 3052589 3053602 + cellobiose transport permease 2SCC13.04%2C probable cellobiose transport permease%2C len: 337 aa%3B highly similar to TR:Q9X9R6 (EMBL:AJ009797) Streptomyces reticuli permease CebF protein%2C 305 aa%3B fasta scores: opt: 1416 z-score: 1722.4 E(): 0%3B 67.9%25 identity in 296 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene2807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2796 SCO2797 SCO2797 2SCC13.05 2SCC13.05 3053615 3054526 + cellobiose transport permease 2SCC13.05%2C probable cellobiose transport permease%2C len: 303 aa%3B highly similar to TR:Q9X9R5 (EMBL:AJ009797) Streptomyces reticuli permease CebG protein%2C 275 aa%3B fasta scores: opt: 1262 z-score: 1477.0 E(): 0%3B 67.8%25 identity in 276 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene2808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2797 SCO2798 SCO2798 2SCC13.06 2SCC13.06 3054670 3056109 + cellobiose hydrolase 2SCC13.06%2C probable cellobiose hydrolase%2C len: 479 aa%3B highly similar to TR:Q59976 (EMBL:Z29625) Streptomyces sp. beta-glucosidase (EC 3.2.1.21) (cellobiose) Bgl3%2C 479 aa%3B fasta scores: opt: 2214 z-score: 2511.6 E(): 0%3B 65.5%25 identity in 472 aa overlap. Contains Pfam match to entry PF00232 Glyco_hydro_1%2C Glycosyl hydrolase family 1 and matches to Prosite entries PS00653 Glycosyl hydrolases family 1 N-terminal signature and PS00572 Glycosyl hydrolases family 1 active site gene gene2809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2798 SCO2799 SCO2799 2SCC13.07c 2SCC13.07c 3056184 3057653 - sugar hydrolase 2SCC13.07c%2C possible sugar hydrolase%2C len: 489 aa%3B similar to the C-terminal region of TR:Q9UWR7 (EMBL:AB024740) Pyrococcus kodakaraensis chitinase PK-ChiA%2C 1215 aa%3B fasta scores: opt: 671 z-score: 561.2 E(): 9.4e-24%3B 31.6%25 identity in 471 aa overlap. Contains Pfam match to entry PF00553 CBD_2%2C Cellulose binding domain and 3x degenerate repeat: PAPT(P/G)TP. Also possible N-terminal region signal peptide sequence gene gene2810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2799 SCO2800 SCO2800 2SCC13.08c 2SCC13.08c 3057814 3059226 - two component system histidine kinase 2SCC13.08c%2C probable two component system histidine kinase%2C len: 470 aa%3B similar to many other Streptomyces coelicolor two component system histidine kinases%2C e.g. TR:Q9RK59 (EMBL:AL132662) histidine kinase SCF11.31c%2C 442 aa%3B fasta scores: opt: 1185 z-score: 1227.7 E(): 0%3B 47.1%25 identity in 448 aa overlap. Contains Pfam matches to entries PF00672 DUF5%2C HAMP domain and PF00512 signal%2C Histidine kinase. Contains possible hydrophobic membrane spanning regions gene gene2811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2800 SCO2801 SCO2801 2SCC13.09c 2SCC13.09c 3059223 3059936 - two component system response regulator 2SCC13.09c%2C probable two component system response regulator%2C len: 234 aa%3B similar to many other Streptomyces coelicolor two component system response regulators%2C e.g. TR:Q9RK58 (EMBL:AL132662) response regulator SCF11.32c%2C 238 aa%3B fasta scores: opt: 894 z-score: 1031.1 E(): 0%3B 60.6%25 identity in 226 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene2812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2801 SCO2802 SCO2802 2SCC13.10 2SCC13.10 3060038 3060619 + hypothetical protein 2SCC13.10%2C possible hypothetical protein%2C len: 193 aa. Contains possible N-terminal region signal peptide sequence gene gene2813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2802 SCO2803 SCO2803 2SCC13.11c 2SCC13.11c 3060648 3061517 - hypothetical protein 2SCC13.11c%2C hypothetical protein%2C len: 289 aa%3B similar to TR:CAB95777 (EMBL:AL359949) Streptomyces coelicolor hypothetical 29.6 kDa protein 2SCG61.02c%2C 281 aa%3B fasta scores: opt: 1064 z-score: 1175.8 E(): 0%3B 61.4%25 identity in 267 aa overlap gene gene2814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2803 SCO2804 SCO2804 2SCC13.12c 2SCC13.12c 3061566 3061961 - hypothetical protein 2SCC13.12c%2C hypothetical protein%2C len: 131 aa%3B similar to TR:O86827 (EMBL:AL031225) Streptomyces coelicolor hypothetical 15.7 kDa protein SC8B7.06c%2C 152 aa%3B fasta scores: opt: 232 z-score: 266.8 E(): 2.4e-07%3B 41.6%25 identity in 113 aa overlap gene gene2815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2804 SCO2805 SCO2805 2SCC13.13 2SCC13.13 3062230 3063669 + hypothetical protein 2SCC13.13%2C hypothetical protein%2C len: 479 aa%3B similar to SW:SP15_STRGR (EMBL:M32687) Streptomyces griseus sporulation related protein ORF1590%2C 529 aa%3B fasta scores: opt: 413 z-score: 469.3 E(): 1.2e-18%3B 30.4%25 identity in 326 aa overlap. Contains 2x conserved repeat: YETHD and 3x degenerate repeat: D(T/A)QD(V/L) gene gene2816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2805 SCO2806 SCO2806 2SCC13.14c 2SCC13.14c 3063968 3064564 - mutase 2SCC13.14c%2C possible mutase%2C len: 198 aa%3B similar to TR:O05852 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 21.9 kDa protein MTCY07D11.12c%2C 203 aa%3B fasta scores: opt: 487 z-score: 602.4 E(): 4.7e-26%3B 42.3%25 identity in 194 aa overlap. Contains Pfam match to entry PF00300 PGAM%2C Phosphoglycerate mutase family gene gene2817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2806 SCO2807 SCO2807 2SCC13.15 2SCC13.15 3064780 3065769 + hypothetical protein 2SCC13.15%2C possible integral membrane protein%2C len: 329 aa%3B similar to TR:CAB90881 (EMBL:AL355752) Streptomyces coelicolor integral membrane protein SC10B7.28%2C 287 aa%3B fasta scores: opt: 598 z-score: 630.9 E(): 1.2e-27%3B 37.7%25 identity in 284 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2807 SCO2808 SCO2808 2SCC13.16 2SCC13.16 3065876 3066904 + hypothetical protein 2SCC13.16%2C possible hypothetical protein%2C len: 342 aa. Contains possible N-terminal region signal peptide sequence gene gene2819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2808 SCO2809 SCO2809 2SCC13.17 2SCC13.17 3066931 3068574 + hypothetical protein 2SCC13.17%2C membrane protein%2C len: 547 aa. Contains possible hydrophobic membrane spanning regions gene gene2820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2809 SCO2810 SCO2810 2SCC13.18 2SCC13.18 3068571 3069932 + hypothetical protein SCBAC17F8.01%2C unknown%2C len: 220aa: no significant database matches.~2SCC13.18%2C unknown (fragment)%2C len: >268 aa gene gene2821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2810 SCO2811 SCO2811 SCBAC17F8.02c SCBAC17F8.02c 3070230 3070556 - regulator SCBAC17F8.02c%2C possible regulator%2C len: 220 aa: similar to many from Gram positives eg. TR:Q52517 (EMBL:M18263) MmyJ from the methylenomycin cluster of plasmid SCP1 from Streptomyces coelicolor (111 aa) fasta scores%3B opt: 242%2C Z-score: 307.2%2C 43.878%25 identity in 98 aa overlap and TR:BAB49625 (EMBL:AP002999) probable regulatory protein from Rhizobium loti (118 aa) fasta scores%3B opt: 174%2C Z-score: 225.5%2C 38.095%25 identity in 84 aa overlap. gene gene2822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2811 SCO2812 SCO2812 SCBAC17F8.03 SCBAC17F8.03 3070648 3071898 + drug efflux protein SCBAC17F8.03%2C possible drug efflux protein%2C len: 416aa: similar to many eg. TR:Q9LA76 (EMBL:AF148322) valanimycin-resistance protein from Streptomyces viridifaciens (402 aa) fasta scores%3B opt: 582%2C Z-score: 614.9%2C 32.405%25 identity (33.952%25 ungapped) in 395 aa overlap and TR:CAC41338 (EMBL:AJ307714) tertracycline resistance protein from Escherichia coli (398 aa) fasta scores%3B opt: 262%2C Z-score: 281.3%2C 28.056%25 identity (32.268%25 ungapped) in 360 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene2823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2812 SCO2813 SCO2813 SCBAC17F8.04 SCBAC17F8.04 3071960 3072526 + hypothetical protein SCBAC17F8.04%2C conserved hypothetical protein%2C len: 188aa: similar to many e.g. TR:BAB48410 (EMBL:AP002996) MLR0926 protein from Rhizobium loti (188 aa) fasta scores%3B opt: 447%2C Z-score: 537.5%2C 38.587%25 identity (39.227%25 ungapped) in 184 aa overlap gene gene2824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2813 SCO2814 SCO2814 SCBAC17F8.05c SCBAC17F8.05c 3072689 3073546 - methyltransferase SCBAC17F8.05c%2C possible methyltransferase%2C len: 285 aa: similar to many some of which reside within antibiotic biosynthetic clusters e.g. TR:Q54818 (EMBL:L35560) doxorubicin polyketide biosynthesis gene from Streptomyces peucetius (286 aa) fasta scores%3B opt: 258%2C Z-score: 287.1%2C 38.136%25 identity (39.130%25 ungapped) in 118 aa overlap%2C TR:Q9S0N6 (EMBL:AB032524) C5-O-methyltransferase AveD from the avermectin biosynthetic cluster of Streptomyces avermitilis (283 aa) fasta scores%3B opt: 249%2C Z-score: 277.5%2C 30.508%25 identity (34.123%25 ungapped) in 236 aa overlap and TR:AAK64748 (EMBL:AE007203) hypothetical protein from Rhizobium meliloti (261 aa) fasta scores%3B opt: 581%2C Z-score: 635.1%2C 41.406%25 identity (42.570%25 ungapped) in 256 aa overlap. gene gene2825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2814 SCO2815 SCO2815 SCBAC17F8.06 SCBAC17F8.06 3073580 3074278 + TetR family transcriptional regulator SCBAC17F8.06%2C possible TetR-family transcriptional regulator%2C len: 232 aa: similar to many hypothetical regulators eg. TR:Q9RWD4 (EMBL:AE001929) TetR-family transcriptional regulator from Deinococcus radiodurans (229 aa) fasta scores%3B opt: 164%2C Z-score: 191.6%2C 34.416%25 identity (36.054%25 ungapped) in 154 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene2826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2815 SCO2816 SCO2816 SCBAC17F8.07 SCBAC17F8.07 3074377 3075477 + hypothetical protein SCBAC17F8.07%2C conserved hypothetical protein%2C len: 366 aa%3B similar to many e.g. TR:Q9I0Z9 (EMBL:AE004676) hypothetical protein from Pseudomonas aeruginosa (333 aa) fasta scores%3B opt: 588%2C Z-score: 637.0%2C 47.826%25 identity (50.305%25 ungapped)in 345 aa overlap gene gene2827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2816 SCO2817 SCO2817 SCBAC17F8.08c SCBAC17F8.08c 3075453 3077357 - hypothetical protein SCBAC17F8.08c%2C conserved hypothetical protein%2C len: 634 aa: similar in regions to many proteins of varying lengths e.g. TR:Q9RCY2 (EMBL:AL133469) hypothetical protein SCM10.16c from Streptomyces coelicolor (714 aa) fasta scores%3B opt: 1259%2C Z-score: 1358.4%2C 43.960%25 identity (46.454%25 ungapped) in 596 aa overlap and TR:Q9HVI8 (EMBL:AE004874) hypothetical protein from Pseudomonas aeruginosa (1415 aa) fasta scores%3B opt: 961%2C Z-score: 1032.5%2C 36.825%25 identity (40.250%25 ungapped) in 611 aa overlap. Contains Pfam match to entry PF00563 EAL%2C Domain of unknown function and Pfam match to entry PF00990 GGDEF%2C GGDEF domain gene gene2828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2817 SCO2818 SCO2818 SCBAC17F8.09 SCBAC17F8.09 3077642 3078952 + hypothetical protein SCBAC17F8.09%2C hypothetical protein%2C len: 436 aa: similar TR:Q9Z4X3 (EMBL:AL035654) hypothetical protein SCE8.01 from Streptomyces coelicolor (432 aa) fasta scores%3B opt: 555%2C Z-score: 609.9%2C 33.991%25 identity (38.945%25 ungapped) in 456 aa overlap gene gene2829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2818 SCO2819 SCO2819 SCBAC17F8.10c SCBAC17F8.10c 3079189 3079803 - hypothetical protein SCBAC17F8.10c%2C hypothetical protein%2C len: 204 aa: similar to many eg. TR:Q9X8N0 (EMBL:AL049628) hypothetical protein SCE94.25 from Streptomyces coelicolor (233 aa) fasta scores%3B opt: 250%2C Z-score: 267.4%2C 36.709%25 identity (39.726%25 ungapped) in 158 aa overlap. gene gene2831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2819 SCO2820 SCO2820 SCBAC17F8.11c SCBAC17F8.11c 3079945 3080292 - hypothetical protein SCBAC17F8.11c%2C hypothetical protein%2C len: 115 aa: no significant database matches. gene gene2832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2820 SCO2821 SCO2821 SCBAC17F8.12c SCBAC17F8.12c 3080444 3082009 - pectate lyase SCBAC17F8.12c%2C possible pectate lyase%2C len: 521 aa: similar to many e.g. TR:Q9KGY6 (EMBL:AF278705) pectate lyase B from Alteromonas haloplanktis (658 aa) fasta scores%3B opt: 1744%2C Z-score: 1590.1%2C 63.301%25 identity (65.859%25 ungapped) in 515 aa overlap and SW:P04959 (PELB_ERWCH) pectate lyase B from Erwinia chrysanthemi (375 aa) fasta scores%3B opt: 413%2C Z-score: 386.2%2C 29.167%25 identity (32.464%25 ungapped) in 384 aa overlap. Contains Pfam match to entry PF00544 pec_lyase%2C Pectate lyase and a probable N-terminal signal sequence. gene gene2833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2821 SCO2822 SCO2822 SCBAC17F8.13c SCBAC17F8.13c 3082430 3083161 - decarboxylase SCBAC17F8.13c%2C possible decarboxylase%2C len: 243 aa: similar to many e.g. SW:Q05115 (AMDA_BORBR) arylmalonate decarboxylase from Alcaligenes bronchisepticus (240 aa) fasta scores%3B opt: 258%2C Z-score: 293.3%2C 33.333%25 identity (34.302%25 ungapped) in 177 aa overlap. Almost identical to TR:Q54412 (EMBL:X52071) hypothetical protein which close alongside transfer RNA-gly in Streptomyces lividans (195 aa) fasta scores%3B opt: 1233%2C Z-score: 1358.6%2C 98.980%25 identity (99.487%25 ungapped) in 196 aa overlap. Also similar to neighbouring CDS SCBAC17F8.14c. gene gene2834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2822 SCO2823 SCO2823 SCBAC17F8.14c SCBAC17F8.14c 3083158 3084060 - decarboxylase SCBAC17F8.14c%2C possible decarboxylase%2C len: 300 aa: similar to many e.g. SW:Q05115 (AMDA_BORBR) arylmalonate decarboxylase from Alcaligenes bronchisepticus (240 aa) fasta scores%3B opt: 328%2C Z-score: 331.2%2C 33.810%25 identity (35.323%25 ungapped) in 210 aa overlap and TR:Q54412 (EMBL:X52071) hypothetical protein which close alongside transfer RNA-gly in Streptomyces lividans (195 aa) fasta scores%3B opt: 295%2C Z-score: 300.7%2C 36.872%25 identity (38.824%25 ungapped) in 179 aa overlap. Also similar to neighbouring CDS SCBAC17F8.13c. gene gene2835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2823 SCO2824 SCO2824 SCBAC17F8.15 SCBAC17F8.15 3084248 3085231 + NAD-binding protein SCBAC17F8.15%2C possible NAD-binding protein%2C len: 327aa: similar to many predicted dehydrogenases eg. TR:Q9KEA4 (EMBL:AP001510) D-3-phosphoglycerate dehydrogenase from Bacillus halodurans (316 aa) fasta scores%3B opt: 523%2C Z-score: 556.0%2C 33.808%25 identity (35.055%25 ungapped) in 281 aa overlap. Contains Pfam match to entry PF02826 2-Hacid_DH_C%2C D-isomer specific 2-hydroxyacid dehydrogenase%2C NAD binding domain but does not contain the corresponding catalytic domain. gene gene2836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2824 SCO2825 SCO2825 SCBAC17F8.16 SCBAC17F8.16 3085268 3086671 + amidase SCBAC17F8.16%2C possible amidase%2C len: 467 aa: similar to many e.g. TR:Q9ZHK8 (EMBL:AF058285) pyrazinamidase from Mycobacterium smegmatis (468 aa) fasta scores%3B opt: 767%2C Z-score: 783.4%2C 34.573%25 identity (35.666%25 ungapped) in 457 aa overlap and SW:Q9Z580 (GATA_STRCO) glutamyl-tRNA amidotransferase subunit A SC8D9.11 from Streptomyces coelicolor (497 aa) fasta scores%3B opt: 628%2C Z-score: 642.1%2C 33.128%25 identity (35.698%25 ungapped) in 486 aa overlap. Contains Pfam match to entry PF01425 Amidase%2C Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00571 Amidases signature gene gene2837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2825 SCO2826 SCO2826 SCBAC17F8.17 SCBAC17F8.17 3086692 3087165 + hypothetical protein SCBAC17F8.17%2C hypothetical protein%2C len: 157 aa: no significant database matches. gene gene2838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2826 SCO2827 SCO2827 SCBAC17F8.18c SCBAC17F8.18c 3087146 3087649 - hypothetical protein SCBAC17F8.18c%2C hypothetical protein%2C len: 167 aa: no significant database matches. gene gene2839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2827 SCO2828 SCO2828 SCE20.02 SCE20.02 3087748 3088677 + amino acid ABC transporter substrate-binding protein SCE20.02%2C probable amino acid ABC transporter%2C solute-binding component%2C len: 309 aa. Similar to several including: Salmonella typhimurium SW:ARGT_SALTY(EMBL:V01368) lysine-arginine-ornithine-binding periplasmic protein precursor (260 aa)%2C fasta scores opt: 251 z-score: 294.5 E(): 5.1e-09 25.8%25 identity in 279 aa overlap and Rhizobium sp. (strain NGR234) SW:Y4TE_RHISN(EMBL:AE000098) probable amino-acid ABC transporter periplasmic binding protein Y4TE (300 aa)%2C fasta scores opt: 599 z-score: 691.7 E(): 3.8e-31 35.4%25 identity in 297 aa overlap. Contains a Pfam match to entry PF00497 SBP_bac_3%2C Bacterial extracellular solute-binding proteins%2C family 3. Also contains an N-terminal possible membrane spanning hydrophobic domain. gene gene2840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2828 SCO2829 SCO2829 SCE20.03 SCE20.03 3088674 3089375 + amino acid ABC transporter transmembrane protein SCE20.03%2C amino acid ABC transporter%2C integral membrane component%2C len: 233 aa. Highly similar to many including: Escherichia coli SW:GLNP_ECOLI(EMBL:X14180) glutamine transport system permease GlnP (219 aa)%2C fasta scores opt: 377 z-score: 445.7 E(): 1.9e-17 27.8%25 identity in 212 aa overlap and Rhizobium sp. (strain NGR234) SW:Y4TF_RHISN(EMBL:AE000098) probable amino-acid ABC transporter permease Y4TF (238 aa)%2C fasta scores opt: 570 z-score: 667.5 E(): 8.5e-30 45.1%25 identity in 204 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains a possible N-terminal signal sequence and possible membrane spanning hydrophobic domains. gene gene2841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2829 SCO2830 SCO2830 SCE20.04 SCE20.04 3089372 3090022 + amino acid ABC transporter transmembrane protein SCE20.04%2C probable amino acid ABC transporter%2C integral membrane component%2C len: 216 aa. Highly similar to several ABC transporter permeases including: Escherichia coli SW:GLNP_ECOLI(EMBL:X14180) glutamine transport system permease GlnP (219 aa)%2C fasta scores opt: 378 z-score: 454.8 E(): 6e-18 33.2%25 identity in 217 aa overlap and Rhizobium sp. (strain NGR234) SW:Y4TG_RHISN(EMBL:AE000098) probable amino-acid ABC transporter permease Y4TG (231 aa)%2C fasta scores opt: 667 z-score: 792.8 E(): 0 47.6%25 identity in 208 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene2842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2830 SCO2831 SCO2831 SCE20.05 SCE20.05 3090012 3090797 + amino acid ABC transporter ATP-binding protein SCE20.05%2C probable amino acid ABC transporter%2C ATP-binding component%2C len: 261 aa. Highly similar to many ATP-binding transport protein including: Bacillus stearothermophilus SW:GLNQ_BACST(EMBL:M61017) glutamine transport ATP-binding protein GLNQ (242 aa)%2C fasta scores opt: 758 z-score: 851.7 E():0 47.5%25 identity in 242 aa overlap and Thermotoga maritima TR:Q9WZ60(EMBL:AE001734) amino acid ABC transporter%2C ATP-binding protein (242 aa)%2C fasta scores opt: 829 z-score: 930.4 E(): 0 54.5%25 identity in 242 aa overlap. Also similar to several other Streptomyces coelicolor transport proteins e.g. TR:O50495(EMBL:AL020958) glutamate uptake system ATP-binding protein%2C GluA (258 aa)%2C fasta scores opt: 775 z-score: 683.3 E(): 1.1e-32 48.2%25 identity in 251 aa overlap. Contains Prosite hits to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene2843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2831 SCO2832 SCO2832 SCE20.06 SCE20.06 3090880 3091737 + IclR family transcriptional regulator SCE20.06%2C possible IclR-family transcriptional regulator%2C len: 285 aa%2C Almost identical to a gene fragment which%2C like SCE20.06%2C is located upstream of the Streptomyces lividans lysT tRNA gene: TR:Q54411(EMBL:X52073) (200 aa)%2C fasta scores opt: 1250 z-score: 1464.9 E():0 99.5%25 identity in 200 aa overlap. Also similar to Streptomyces coelicolor TR:Q9X9U3(EMBL:AL096823) transcriptional regulator (241 aa)%2C fasta scores opt: 597 z-score: 704.2 E(): 7.7e-32 43.2%25 identity in 236 aa overlap. Contains a Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator with a helix-turn-helix motif situated between residues 41..62 (+3.07 SD). gene gene2844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2832 SCO2833 SCO2833 chb chb 3091946 3092551 - chitin binding protein SCE20.07c%2C chb%2C chitin binding protein%2C len: 201 aa. Highly similar to several including: Streptomyces olivaceoviridis (Streptomyces corchorusii) TR:Q54501(EMBL:X78535) chitin binding protein precursor Chb1 (201 aa)%2C fasta scores opt: 1185 z-score: 1303.0 E():0 83.7%25 identity in 202 aa overlap and Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (Chb2) (201 aa)%2C fasta scores opt: 1161 z-score: 1276.8 E(): 0 79.1%25 identity in 201 aa overlap. Contains a possible N-terminal signal sequence. gene gene2846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2833 SCO2834 SCO2834 SCE20.08c SCE20.08c 3092672 3093823 - hypothetical protein SCE20.08c%2C possible membrane protein%2C len: 383 aa%3B C-terminal region similar to TR:Q9KIM1 (EMBL:AF230489) Streptomyces coelicolor F42A (integral membrane protein) or SCK7.11c%2C 312 aa%3B fasta scores: opt: 467 Z-score: 441.6 E(): 5.8e-17%3B 31.229%25 identity in 301 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene2847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2834 SCO2835 SCO2835 SCE20.09c SCE20.09c 3093880 3094941 - hypothetical protein SCE20.09c%2C possible membrane protein%2C len: 353 aa. Contains a possible membrane spanning hydrophobic domain and is rich in the amino acid Ala. gene gene2848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2835 SCO2836 SCO2836 SCE20.10 SCE20.10 3095506 3097467 + glycosyl transferase SCE20.10%2C possible glycosyl transferase.%2C len: 653 aa. Weakly similar to several other glycosyl transferases e.g. Aquifex aeolicus TR:O67406 (EMBL:AE000738) cellulose synthase catalytic subunit (759 aa)%2C fasta scores opt: 326 z-score: 359.1 E(): 1.3e-12 22.0%25 identity in 590 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases and multiple possible membrane spanning hydrophobic domains gene gene2850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2836 SCO2837 SCO2837 SCE20.11 SCE20.11 3097464 3099401 + hypothetical protein SCE20.11%2C possible hypothetical protein%2C len: 645 aa. Weakly similar to a Eukaryotic galactose oxidase precursor (EC 1.1.3.9) from Dactylium dendroides (Cladobotryum dendroides) SW:GAOA_DACDE(EMBL:M86819) (680 aa)%2C fasta scores opt: 350 z-score: 374.4 E(): 1.8e-13 26.8%25 identity in 400 aa overlap. Contains a possible N-terminal signal sequence. gene gene2851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2837 SCO2838 SCO2838 SCE20.12c SCE20.12c 3099502 3100500 - endoglucanase SCE20.12c%2C possible endoglucanase%2C len: 332 aa. Similar to many including: Streptomyces halstedii SW:GUN1_STRHA(EMBL:Z12157) endoglucanase 1 precursor (EC 3.2.1.4) (321 aa)%2C fasta scores opt: 613 z-score: 677.4 E(): 2.4e-30 37.6%25 identity in 343 aa overlap and Mycobacterium tuberculosis TR:O53607(EMBL:AL021428) cellulase (380 aa)%2C fasta scores opt: 796 z-score: 876.5 E():0 44.3%25 identity in 298 aa overlap. Note that codon 10 maybe the true initiation codon. Contains a Pfam match to entry PF01341 Glyco_hydro_6%2C Glycosyl hydrolases and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a possible N-terminal signal sequence. gene gene2852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2838 SCO2839 SCO2839 SCE20.13c SCE20.13c 3100609 3101196 - lipoprotein SCE20.13c%2C possible lipoprotein%2C len: 190 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. gene gene2853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2839 SCO2840 SCO2840 SCE20.14. SCE20.14. 3101313 3102206 + LysR family transcriptional regulator SCE20.14%2C possible LysR-family transcriptional regulatory protein%2C len: 297 aa. Similar to many other regulators including: Bacillus subtilis SW:ALSR_BACSU (EMBL:L04470%3B) als operon regulatory protein (302 aa). fasta scores opt: 373 z-score: 437.5 E(): 5.5e-17 26.6%25 identity in 286 aa overlap and Streptomyces lividans TR:Q9X9S5 (EMBL:Y18818) transcriptional regulator of LysR family (307 aa)%2C fasta scores opt: 449 z-score: 525.1 E(): 7.3e-22 34.0%25 identity in 303 aa overlap. Contains a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family with a helix-turn-helix motif situated between residues 17..38 (+4.47 SD). gene gene2854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2840 SCO2841 SCO2841 SCE20.15c SCE20.15c 3102196 3102936 - hypothetical protein SCE20.15c%2C possible hypothetical protein%2C len: 246 aa%3B similar to TR:Q9L2D9 (EMBL:AL137187) Streptomyces coelicolor hypothetical protein SC7A8.16c%2C 210 aa%3B fasta scores: opt: 493 Z-score: 488.6 E(): 1.4e-19%3B 40.580%25 identity in 207 aa overlap. Contains a possible membrane spanning hydrophobic domain gene gene2855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2841 SCO2842 SCO2842 SCE20.16c SCE20.16c 3102939 3103493 - hypothetical protein SCE20.16c%2C possible membrane protein%2Clen: 184 aa. Contains possible membrane spanning hydrophobic domain and a possible N-terminal signal sequence. gene gene2856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2842 SCO2843 SCO2843 nagD nagD 3103597 3104376 - N-acetylglucosamine-6-phosphate deacetylase SCE20.17c%2C nagD%2C probable N-acetylglucosamine-6-phosphate deacetylase%2C len: 259 aa. Highly similar to Escherichia coli SW:NAGD_ECOLI(EMBL:X14135) possible N-acetylglucosamine-6-phosphate deacetylase NagD (250 aa)%2C fasta scores opt: 740 z-score: 847.6 E(): 0 43.0%25 identity in 249 aa overlap. gene gene2857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2843 SCO2844 SCO2844 SCE20.18c SCE20.18c 3104452 3104547 - hypothetical protein SCE20.18c%2C doubtful CDS%2C len: 31 aa. gene gene2858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2844 SCO2845 SCO2845 SCE20.19c SCE20.19c 3104547 3104891 - GntR family transcriptional regulator SCE20.19c%2C possible GntR-family transcriptional regulatory protein%2C len: 114 aa. Weakly similar to Streptomyces coelicolor TR:CAB60175(EMBL:AL132824) transcriptional regulator (245 aa)%2C fasta scores opt: 143 z-score: 180.9 E(): 0.011%2C 38.8%25 identity in 80 aa overlap and Bacillus subtilis TR:O34817(EMBL:AF017113) GntR family of transcriptional regulator YvoA (243 aa)%2C fasta scores opt: 198 z-score: 245.5 E(): 2.7e-06. 38.1%25 identity in 97 aa overlap. Contains a Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family with a helix-turn-helix motif situated between residues 25..46 (+4.27 SD). gene gene2859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2845 SCO2846 SCO2846 SCE20.20c SCE20.20c 3105013 3106233 - transcriptional regulator SCE20.20c%2C possible transcriptional regulatory protein%2C len: 406 aa. Similar in parts to several proteins of the ROK (NagC/XylR) family including: Bacillus subtilis SW:GLK_BACSU (EMBL:D84432) glucokinase (EC 2.7.1.2) (glucose kinase) (321 aa)%2C fasta scores opt: 320 z-score: 310.6 E(): 6.4e-10 34.1%25 identity in 164 aa overlap and Thermotoga maritima TR:Q9X1I0 (EMBL:AE001798) glucokinase (317 aa)%2C fasta scores opt: 385 z-score: 370.1 E(): 3.1e-13 33.6%25 identity in 360 aa overlap. Contains a Prosite hits to PS01125 ROK family signature and PS01228 Hypothetical cof family signature 1. Also contains a Pfam match to entry PF00480 ROK%2C ROK family and a helix-turn-helix motif situated between residues 45..66 (+5.25 SD). gene gene2860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2846 SCO2847 SCO2847 SCE20.21 SCE20.21 3106290 3107372 + oxidoreductase SCE20.21%2C possible oxidoreductase%2C len: 360 aa. Similar to several other oxidoreductases e.g. Escherichia coli SW:YDGJ_ECOLI(EMBL:AE000258) hypothetical oxidoreductase (346 aa)%2C fasta scores opt: 873 z-score: 972.9 E():0 45.0%25 identity in 353 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene2861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2847 SCO2848 SCO2848 SCE20.22 SCE20.22 3107369 3107845 + hypothetical protein SCE20.22%2C unknown%2C len: 158 aa. Similar to several proteins of undefined function e.g. Rhizobium meliloti SW:YPMI_RHIME(EMBL:M96584) hypothetical 18.2 KD protein (164 aa)%2C fasta scores opt: 434 z-score: 540.5 E(): 1e-22 49.7%25 identity in 143 aa overlap. Also similar to Saccharomyces cerevisiae SW:YBY7_YEAST(EMBL:X75891) hypothetical 20.5 KD protein (179 aa)%2C fasta scores opt: 278 z-score: 350.5 E(): 3.8e-12 38.8%25 identity in 152 aa overlap gene gene2862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2848 SCO2849 SCO2849 SCE20.23 SCE20.23 3107953 3108825 + hypothetical protein SCE20.23%2C unknown%2C len: 290 aa. Similar to a protein of undefined function from Mycobacterium tuberculosis TR:O06328(EMBL:Z95390) hypothetical 30.7 KD protein (285 aa)%2C fasta scores opt: 770 z-score: 928.4 E(): 0 48.6%25 identity in 247 aa overlap. gene gene2863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2849 SCO2850 SCO2850 SCE20.24c SCE20.24c 3109095 3109952 - 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase SCE20.24c%2C possible 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase%2C len: 285 aa. Similar to many including: Mycobacterium tuberculosis TR:O53242 (EMBL:AL021287) possible 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (239 aa)%2C fasta scores opt: 544 z-score: 651.1 E(): 7e-29 40.3%25 identity in 221 aa overlap and similar in parts to the C-terminus of Escherichia coli SW:HPCE_ECOLI (EMBL:X75028) 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (EC 5.3.3.-) (405 aa)%2C fasta scores opt: 467 z-score: 556.6 E(): 1.3e-23 40.2%25 identity in 214 aa overlap. Also similar to Streptomyces coelicolor TR:CAB55708 (EMBL:AL117387) 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase SCF41.05 (292 aa)%2C fasta scores opt: 1142 z-score: 1213.4 E():0 61.5%25 identity in 286 aa overlap. Contains a Pfam match to entry PF01557 FAA_hydrolase%2C Fumarylacetoacetate (FAA) hydrolase family. gene gene2864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2850 SCO2851 SCO2851 SCE20.25c SCE20.25c 3110120 3110833 - hypothetical protein SCE20.25c%2C possible membrane protein%2C len: 237 aa. Similar in parts to many bacterial inner membrane proteins e.g. Streptomyces coelicolor TR:O54569(EMBL:Y16311) inner membrane protein%2C STH24.05 (431 aa)%2C fasta scores opt: 240 z-score: 285.1 E(): 1.7e-08 25.0%25 identity in 232 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene2865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2851 SCO2852 SCO2852 SCE20.26c SCE20.26c 3110947 3111282 - hypothetical protein SCE20.26c%2C possible membrane protein%2C len: 111 aa. Contains a possible N-terminal membrane spanning hydrophobic domain. gene gene2866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2852 SCO2853 SCO2853 SCE20.27c SCE20.27c 3111340 3111894 - hypothetical protein SCE20.27c%2C unknown%2C len: 184 aa. Similar to many proteins of unknown function including: Mycobacterium tuberculosis SW:YU95_MYCTU(EMBL:Z95150) hypothetical 17.8 KD protein (158 aa)%2C fasta scores opt: 396 z-score: 478.9 E(): 2.7e-19 42.6%25 identity in 141 aa overlap and Streptomyces coelicolor TR:O86588(EMBL:AL031514) hypothetical 23.3 KD protein SC2H4.05 (216 aa)%2C fasta scores opt: 294 z-score: 357.1 E(): 1.7e-12 44.6%25 identity in 112 aa overlap. Contains a Pfam match to entry PF01638 DUF24%2C Protein of unknown function gene gene2867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2853 SCO2854 SCO2854 SCE20.28 SCE20.28 3111998 3113431 + transmembrane efflux protein SCE20.28%2C possible transmembrane efflux protein%2C len: 477 aa. Similar to many including: Mycobacterium smegmatis TR:Q50392(EMBL:U40487) proton antiporter efflux pump (504 aa)%2C fasta scores opt: 626 z-score: 586.9 E(): 2.6e-25 32.1%25 identity in 471 aa overlap and Streptomyces coelicolor TR:Q9ZBW5(EMBL:AL034443) integral membrane efflux protein SC4B5.03C (504 aa)%2C fasta scores opt: 729 z-score: 681.9 E(): 1.3e-30 36.6%25 identity in 435 aa overlap. Contains a Prosite hit to PS00216 Sugar transport proteins signature 1 and multiple possible membrane spanning hydrophobic domains. gene gene2868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2854 SCO2855 SCO2855 SCE20.29 SCE20.29 3113643 3114659 + hypothetical protein SCE20.29%2C unknown%2C len: 338 aa. gene gene2869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2855 SCO2856 SCO2856 SCE20.30 SCE20.30 3114765 3115223 + hypothetical protein SCE20.30%2C unknown%2C len: 152 aa. Similar to another protein of unknown function from Streptomyces coelicolor TR:O86819(EMBL:AL031031) SC7C7.14 (161 aa)%2C fasta scores opt: 152 z-score: 189.7 E(): 0.0035 31.7%25 identity in 123 aa overlap. gene gene2870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2856 SCO2857 SCO2857 SCE20.31c SCE20.31c 3115344 3115688 - hypothetical protein SCE20.31c%2C possible membrane protein%2C len: 114 aa. Contains possible membrane spanning hydrophobic domains and an N-terminal signal sequence. gene gene2871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2857 SCO2858 SCO2858 SCE20.32c SCE20.32c 3115703 3115960 - hypothetical protein SCE20.32c%2C unknown%2C len: 85 aa. gene gene2872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2858 SCO2859 SCO2859 SCE20.33c SCE20.33c 3115957 3116334 - hypothetical protein SCE20.33c%2C unknown%2C len: 125 aa. Similar several other proteins of unknown function e.g. from Lactococcus lactis TR:O87247(EMBL:AE001272) conserved hypothetical protein (114 aa)%2C fasta scores opt: 226 z-score: 311.1 E(): 6e-10 35.1%25 identity in 94 aa overlap. gene gene2873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2859 SCO2860 SCO2860 arr arr 3116521 3116931 - rifampin ADP-ribosyl transferase SCE20.34c%2C arr%2C rifampin ADP-ribosyl transferase%2C len 136 aa. Highly similar to Mycobacterium smegmatis TR:O67972 (EMBL:AF001493) rifampin ADP-ribosyl transferase (143 aa)%2C fasta scores opt: 487 z-score: 611.8 E(): 1.1e-26 53.0%25 identity in 134 aa overlap and Pseudomonas aeruginosa TR:O87490 (EMBL:AF078527) ribosylating transferase ARR-2 (150 aa)%2C fasta scores opt: 429 z-score: 540.3 E(): 1e-22 50.0%25 identity in 128 aa overlap gene gene2874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2860 SCO2861 SCO2861 SCE20.35. SCE20.35. 3117159 3117881 + hypothetical protein SCE20.35%2C unknown%2C len: 240 aa. gene gene2875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2861 SCO2862 SCO2862 SCE20.36c SCE20.36c 3117978 3118211 - hypothetical protein SCE20.36c%2C unknown%2C len: 77 aa. gene gene2876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2862 SCO2863 SCO2863 SCE20.37 SCE20.37 3118362 3121199 + helicase SCE20.37%2C possible helicase%2C len: 945 aa. Weakly similar to Saccharomyces cerevisiae (Baker's yeast) TR:Q06683(EMBL:U32517) DEAD box family helicase family protein (689 aa)%2C fasta scores opt: 455 z-score: 511.5 E(): 4.1e-21 27.2%25 identity in 357 aa overlap. Also weakly similar to several bacteriophage proteins including: Lactococcus bacteriophage (isolate 7-9) SW:V51K_BPL79 (EMBL:M36388) 51.5 KD protein which may play a role in either regulating bacteriophage replication or bacteriophage specific genes (452 aa)%2C fasta scores opt: 407 z-score: 460.0 E(): 3.1e-18 27.4%25 identity in 328 aa overlap. Contains Prosite hit to 2xPS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain. gene gene2877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2863 SCO2864 SCO2864 SCE6.01c SCE6.01c 3121344 3121892 - hypothetical protein SCE6.01c%2C unknown%2C partial CDS%2C len: > 183 aa. Similar to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9XD95(EMBL:AF106004) hypothetical 15.4 KD protein found within the whiJ sporulation regulatory locus (141 aa)%2C fasta scores opt: 232 z-score: 304.9 E(): 1.5e-09 37.4%25 identity in 131 aa overlap and Streptomyces coelicolor TR:Q9ZBT2(EMBL:AL034446) regulatory protein%2C SC1A9.20 (135 aa)%2C fasta scores opt: 201 z-score: 266.1 E(): 2.2e-07 38.3%25 identity in 120 aa overlap. gene gene2878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2864 SCO2865 SCO2865 SCE6.02 SCE6.02 3122091 3122933 + regulatory protein SCE6.02%2C possible regulatory protein%2C len: 280 aa. Similar to several proteins of undefined function including: Streptomyces albulus TR:BAA89264 (EMBL:AB025200) hypothetical protein ORF312 (285 aa)%2C fasta scores opt: 585 z-score: 728.2 E():0 38.2%25 identity in 280 aa overlap and Streptomyces coelicolor TR:Q9Z543 (EMBL:AL035212) DNA binding protein%2C SC9B2.16C (303 aa)%2C fasta scores opt: 313 z-score: 391.9 E(): 2.1e-14 31.0%25 identity in 284 aa overlap. Also weakly similar to SCE6.06%2C also located on this cosmid%2C fasta scores opt: 269 z-score: 293.0 E(): 8.1e-11 27.5%25 identity in 265 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix with the helix-turn-helix motif situated between residues 25..46 (+5.35 SD). gene gene2879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2865 SCO2866 SCO2866 SCE6.03 SCE6.03 3123223 3123477 + hypothetical protein SCE6.03%2C unknown%2C len: 84 aa. gene gene2880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2866 SCO2867 SCO2867 SCE6.04 SCE6.04 3123679 3123906 + hypothetical protein SCE6.04%2C unknown%2C len: 75 aa. Similar to another hypothetical protein from Streptomyces coelicolor TR:CAB53305 (EMBL:AL109973) SCJ30.10C (92 aa)%2C fasta scores opt: 101 z-score: 154.5 E(): 0.35 32.1%25 identity in 81 aa overlap. gene gene2881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2867 SCO2868 SCO2868 SCE6.05 SCE6.05 3123914 3124393 + hypothetical protein SCE6.05%2C hypothetical protein%2C len: 159 aa. The C-terminus shares 54.1%25 identity in 74 aa overlap with Streptomyces coelicolor TR:CAB53304(EMBL:AL109973) hypothetical 10.9 KD protein%2C SCJ30.09C (96 aa)%3B similar also to the SCP1 plasmid borne TR:Q9ACW6 (EMBL:AL590464) Streptomyces coelicolor conserved hypothetical protein SCP1.185%2C 184 aa%3B fasta scores: opt: 520 Z-score: 652.0 E(): 1.1e-28%3B 49.390%25 identity in 164 aa overlap gene gene2882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2868 SCO2869 SCO2869 SCE6.06 SCE6.06 3124417 3125262 + regulatory protein SCE6.06%2C possible regulatory protein%2C len: 281 aa. Similar to several proteins of undefined function e.g. Streptomyces albulus TR:BAA89264(EMBL: AB025200) plasmid pNO33 protein ORF312 (285 aa)%2C fasta scores opt: 356 z-score: 441.0 E(): 3.9e-17 30.9%25 identity in 282 aa overlap. Also weakly similar to SCE6.02%2C also located on this cosmid%2C fasta scores opt: 269 z-score: 293.0 E(): 8.1e-11 27.5%25 identity in 265 aa overlap. Contains a helix-turn-helix motif situated between residues 27..48 (+4.07 SD). gene gene2883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2869 SCO2870 SCO2870 SCE6.07 SCE6.07 3125334 3125630 + hypothetical protein SCE6.07%2C unknown%2C len: 98 aa. gene gene2884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2870 SCO2871 SCO2871 SCE6.08 SCE6.08 3125634 3126614 + hypothetical protein SCE6.08%2C unknown%2C len: 326 aa. Similar to Streptomyces coelicolor TR:CAB69667(EMBL:AL137165) hypothetical 34.9 kd protein%2C SCF42.05 (328 aa)%2C fasta scores opt: 371 z-score: 450.8 E(): 1.1e-17 35.6%25 identity in 334 aa overlap. gene gene2885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2871 SCO2872 SCO2872 SCE6.09 SCE6.09 3126611 3127843 + hypothetical protein SCE6.09%2C unknown%2C len: 410 aa. Weakly similar to several methyltransferase e.g. Streptomyces coelicolor TR:CAB71208(EMBL:AL138538) O-methyltransferase%2C SC6D10.13C (324 aa)%2C fasta scores opt: 337 z-score: 387.6 E(): 3.7e-14 37.2%25 identity in 277 aa overlap. gene gene2886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2872 SCO2873 SCO2873 SCE6.10c SCE6.10c 3127894 3128439 - hypothetical protein SCE6.10c%2C unknown%2C len: 181 aa. Shows weak similarity to Streptomyces coelicolor TR:CAB51981 (EMBL:AL109663) hypothetical protein%2C SC4A10.05C (160 aa)%2C fasta scores opt: 171 z-score: 221.2 E(): 6.9e-05 32.7%25 identity in 156 aa overlap. gene gene2887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2873 SCO2874 SCO2874 SCE6.11c SCE6.11c 3128619 3129590 - oxidoreductase SCE6.11c%2C possible oxidoreductase%2C len: 323 aa. Similar to several other members of the short-chain dehydrogenases/reductases family including: Streptomyces antibioticus SW:OXIR_STRAT(EMBL:M96551) probable oxidoreductase (298 aa)%2C fasta scores opt: 641 z-score: 722.8 E(): 7.9e-33 43.4%25 identity in 304 aa overlap and Streptomyces coelicolor TR:AAF26372(EMBL:AF204735) NADP-dependent oxidoreductase (297 aa)%2C fasta scores opt: 670 z-score: 755.1 E(): 0 43.9%25 identity in 289 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene2888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2874 SCO2875 SCO2875 SCE6.12 SCE6.12 3129670 3130077 + MerR family transcriptional regulator SCE6.12%2C possible MerR-family transcriptional regulator%2C len: 135 aa. Similar to many regulators e.g. Haemophilus influenzae SW:Y186_HAEIN(EMBL:U32704) hypothetical transcriptional regulator (135 aa)%2C fasta scores opt: 233 z-score: 315.6 E(): 3.8e-10 33.9%25 identity in 121 aa overlap. Also similar to Streptomyces coelicolor TR:CAB62710(EMBL:AL133423) MerR-family transcriptional regulator%2C SC4A7.06C (196 aa)%2C fasta scores opt: 295 z-score: 393.5 E(): 1.7e-14 41.2%25 identity in 119 aa overlap. Contains a Prosite hit to PS00552 Bacterial regulatory proteins%2C merR family signature and a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family with a helix-turn-helix motif situated between residues 6..27 (+4.68 SD). gene gene2889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2875 SCO2876 SCO2876 SCE6.13 SCE6.13 3130105 3130731 + acetyltransferase SCE6.13%2C possible acetyltransferase%2C len: 208 aa. Similar to several including: Escherichia coli SW:ATDA_ECOLI(EMBL:D25276) spermidine N1-acetyltransferase (EC 2.3.1.57) (185 aa)%2C fasta scores opt: 208 z-score: 273.6 E(): 8.2e-08 25.3%25 identity in 158 aa overlap and Streptomyces coelicolor TR:CAB76075(EMBL:AL157953) acetyltransferase%2C SCL11.12C (232 aa)%2C fasta scores opt: 287 z-score: 372.5 E(): 2.6e-13 33.7%25 identity in 187 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene2890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2876 SCO2877 SCO2877 SCE6.14 SCE6.14 3130825 3131211 + hypothetical protein SCE6.14%2C possible membrane protein%2C len: 128 aa. Contains an N-terminal membrane spanning hydrophobic domain. gene gene2891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2877 SCO2878 SCO2878 SCE6.15 SCE6.15 3131350 3133899 + hypothetical protein SCE6.15%2C unknown%2C len: 849 aa. Contains degenerate repeats: 3xNR(N/H)TART and 3xAAGEAAAVA(Q/A). The predicted product of this CDS is also rich in the amino acid Ala and contains coiled-coils between residues 194..257 and 587..612. gene gene2892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2878 SCO2879 SCO2879 cvnA12 cvnA12 3134618 3136273 + hypothetical protein SCE6.16%2C cvnA12%2C possible membrane protein%2C len: 551 aa. Similar to many Streptomyces coelicolor proteins e.g. TR:CAB59483 (EMBL:AL132648) integral membrane protein%2C SCI41.13C (541 aa)%2C fasta scores opt: 449 z-score: 340.7 E(): 1.5e-11 27.5%25 identity in 564 aa overlap. Contains a possible hydrophobic membrane spanning region and coiled-coils between residues 120..140 gene gene2893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2879 SCO2880 SCO2880 cvnB12 cvnB12 3136276 3136698 + hypothetical protein SCE6.17%2C cvnB12%2C unknown%2C len: 140 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:Q9X835 (EMBL:AL049727) SC9B1.15C (139 aa)%2C fasta scores opt: 222 z-score: 297.5 E(): 3.9e-09 34.3%25 identity in 134 aa overlap and TR:CAB61281 (EMBL:AL132991) SCF55.11C (152 aa)%2C fasta scores opt: 221 z-score: 295.6 E(): 4.9e-09 32.6%25 identity in 138 aa overlap. Contains a Pfam match to entry PF01860 DUF42%2C Protein of unknown function. gene gene2894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2880 SCO2881 SCO2881 cvnC12 cvnC12 3136695 3137048 + hypothetical protein SCE6.18%2C cvnC12%2C unknown%2C len: 117 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:CAB71243 (EMBL:AL138598) SC1A2.05 (126 aa)%2C fasta scores opt: 194 z-score: 251.3 E(): 1.4e-06 38.7%25 identity in 119 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa)%2C fasta scores opt: 192 z-score: 249.3 E(): 1.9e-06 37.9%25 identity in 124 aa overlap. gene gene2895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2881 SCO2882 SCO2882 cvnD12 cvnD12 3137116 3137664 + ATP/GTP-binding protein SCE6.19%2C cvnD12%2C possible ATP/GTP-binding protein%2C len: 182 aa. Highly similar to many other ATP/GTP-binding proteins from Streptomyces coelicolor including: TR:CAB59480 (EMBL:AL132648) SCI41.10C (176 aa)%2C fasta scores opt: 618 z-score: 748.9 E(): 0 58.4%25 identity in 166 aa overlap and TR:Q9X833 (EMBL:AL049727) SC9B1.13C (181 aa)%2C fasta scores opt: 588 z-score: 712.9 E(): 2.8e-32 53.4%25 identity in 176 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) gene gene2896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2882 SCO2883 SCO2883 SCE6.20 SCE6.20 3137661 3138893 + cytochrome P450 SCE6.20%2C possible cytochrome P450%2C len: 410 aa. Highly similar to many other cytochrome P450 proteins from Streptomyces including: S. coelicolor TR:CAB61278 (EMBL:AL132991) SCF55.08C (420 aa)%2C fasta scores opt: 710 z-score: 807.4 E():0 33.1%25 identity in 411 aa overlap and S. violaceus (S. venezuelae) TR:O87605 (EMBL:AF087022) cytochrome P450 monooxygenase%2C PikC (416 aa)%2C fasta scores opt: 464 z-score: 529.1 E(): 4.8e-22 30.2%25 identity in 411 aa overlap. Also similar to the adjoining CDS SCE6.21 (408 aa)%2C fasta scores opt: 257 z-score: 252.4 E(): 1.5e-08 26.5%25 identity in 407 aa overlap. Contains a Prosite hit to PS00086 Cytochrome P450 cysteine heme-iron ligand signature. gene gene2897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2883 SCO2884 SCO2884 SCE6.21 SCE6.21 3138905 3140131 + cytochrome P450 SCE6.21%2C possible cytochrome P450%2C len: 408 aa. Highly similar to many other cytochrome P450 proteins including: Saccharopolyspora erythraea (Streptomyces erythraeus) SW:CPXJ_SACER(EMBL:X60379) 6-deoxyerythronolide B hydroxylase (404 aa)%2C fasta scores opt: 777 z-score: 888.8 E():0 37.8%25 identity in 410 aa overlap and Streptomyces fradiae TR:Q9XCC6(EMBL:AF145049) (433 aa)%2C fasta scores opt: 1253 z-score: 1430.3 E():0 50.9%25 identity in 409 aa overlap. Also similar to the adjoining CDS SCE6.20 (410 aa)%2C fasta scores opt: 257 z-score: 252.4 E(): 1.5e-08 26.5%25 identity in 407 aa overlap. Contains a PS00086 Cytochrome P450 cysteine heme-iron ligand signature and a Pfam match to entry PF00067 p450%2C Cytochrome P450. gene gene2898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2884 SCO2885 SCO2885 SCE6.22c SCE6.22c 3140184 3140657 - hypothetical protein SCE6.22c%2C unknown%2C len: 157 aa. Highly similar to another hypothetical protein from Streptomyces coelicolor TR:CAB66282 (EMBL:AL136519) SCC57A.14 (161 aa)%2C fasta scores opt: 611 z-score: 780.6 E():0 58.3%25 identity in 156 aa overlap gene gene2899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2885 SCO2886 SCO2886 SCE6.23c SCE6.23c 3140760 3141644 - hydrolase SCE6.23c%2C possible hydrolase%2C len: 294 aa. Similar to several including: Mycobacterium sp. TR:Q9ZER0 (EMBL:AJ012627) haloalkane dehalogenase%2C DhaAF (307 aa)%2C fasta scores opt: 347 z-score: 425.8 E(): 2.7e-16 27.4%25 identity in 292 aa overlap and Deinococcus radiodurans TR:AAF12090 (EMBL:AE002084) epoxide hydrolase-related protein (278 aa)%2C fasta scores opt: 402 z-score: 493.2 E(): 4.8e-2032.4%25 identity in 284 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene2900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2886 SCO2887 SCO2887 SCE6.24 SCE6.24 3141805 3142107 + hypothetical protein SCE6.24%2C possible membrane protein%2C len: 100. The predicted product of this CDS is rich in the amino acid Ala and contains several possible hydrophobic membrane spanning domains. gene gene2901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2887 SCO2888 SCO2888 SCE6.25c SCE6.25c 3142123 3142482 - hypothetical protein SCE6.25c%2C unknown%2C len: 119 aa. similar to TR:CAC46858 (EMBL:AL591790) hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) (120 aa) fasta scores%3B opt: 360%2C Z-score: 449.2%2C E(): 2.2e-17%2C 48.305%25 identity (49.565%25 ungapped) in 118 aa overlap. Weakly similar in parts to Streptomyces coelicolor TR:O86701(EMBL:AL031515) lyase%2C SC5C7.04 (138 aa)%2C fasta scores opt: 141 z-score: 193.4 E(): 0.0024 33.3%25 identity in 111 aa overlap. gene gene2902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2888 SCO2889 SCO2889 SCE6.26c SCE6.26c 3142528 3144042 - sugar transport protein SCE6.26c%2C possible sugar transport protein%2C len: 504 aa. Similar to several Eukaryotic and Prokaryotic transport proteins including: Schizosaccharomyces pombe (Fission yeast) SW:ITR2_SCHPO(EMBL:Z95334) myo-inositol transporter 2 (557 aa)%2C fasta scores opt: 422 z-score: 488.9 E(): 8.4e-20 27.6%25 identity in 467 aa overlap and Bacillus subtilis SW:YYAJ_BACSU(EMBL:D26185) hypothetical metabolite transport protein (451 aa)%2C fasta scores opt: 420 z-score: 487.9 E(): 9.6e-20 27.7%25 identity in 451 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and multiple possible membrane spanning hydrophobic domains. gene gene2903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2889 SCO2890 SCO2890 SCE6.27c SCE6.27c 3144126 3145338 - gene gene2904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2890 SCO2892 SCO2892 SCE6.29 SCE6.29 3145726 3147090 + hypothetical protein SCE6.29%2C possible hypothetical protein%2C len: 454 aa. Similar to another hypothetical protein from Streptomyces coelicolor: TR:CAB56661(EMBL:AL121596) SCF51A.09C (442 aa)%2C fasta scores opt: 614 z-score: 649.3 E(): 9.8e-29 31.3%25 identity in 454 aa overlap. Contains a possible N-terminal signal sequence. gene gene2905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2892 SCO2893 SCO2893 SCE6.30c SCE6.30c 3147118 3147951 - hypothetical protein SCE6.30c%2C unknown%2C len: 277 aa. Similar to several proteins of undefined function e.g. Mycobacterium leprae TR:Q9Z5H1(EMBL:AL035500) hypothetical 22.1 kd protein (200 aa)%2C fasta scores opt: 413 z-score: 443.6 E(): 2.8e-17 41.5%25 identity in 205 aa overlap. Contains a possible coiled-coil between residues 206..226. gene gene2906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2893 SCO2894 SCO2894 SCE6.31c SCE6.31c 3147985 3149049 - ABC transporter ATP-binding protein SCE6.31c%2C possible ABC-transport protein%2C ATP-binding component%2C len: 354 aa. Similar to many other proposed transport proteins e.g. Synechocystis sp. (strain PCC 6803) TR:P73329(EMBL:D90905) ABC transporter (326 aa)%2C fasta scores opt: 831 z-score: 906.9 E(): 0 45.3%25 identity in 296 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene2907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2894 SCO2895 SCO2895 SCE6.32c SCE6.32c 3149058 3149945 - integral membrane transport protein SCE6.32c possible integral membrane transport protein%2C len: 295 aa. Similar to Deinococcus radiodurans TR:AAF09789(EMBL:AE001882) conserved hypothetical protein (277 aa)%2C fasta scores. Also weakly similar to the adjoining CDS SCE6.33c%2C fasta scores opt: 174 z-score: 186.6 E(): 6.9e-05 29.4%25 identity in 269 aa overlap. Contains a Prosite hit to PS00216 Sugar transport proteins signature 1 and multiple possible membrane spanning hydrophobic domains. Also contains an N-terminal 5xEAA repeat sequence. gene gene2908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2895 SCO2896 SCO2896 SCE6.33c SCE6.33c 3149938 3150744 - hypothetical protein SCE6.33c%2C possible integral membrane protein%2C len: 268 aa. Similar to a protein of undefined function from Deinococcus radiodurans TR:AAF09788(EMBL:AE001882) conserved hypothetical protein (275 aa)%2C fasta scores: opt: 521 z-score: 606.4 E(): 2.4e-26 38.6%25 identity in 272 aa overlap. Also weakly similar to the adjoining CDS SCE6.32c%2C fasta scores: opt: 174 z-score: 186.6 E(): 6.9e-05 29.4%25 identity in 269 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene2909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2896 SCO2897 SCO2897 SCE6.34 SCE6.34 3151125 3153395 + penicillin-binding protein SCE6.34%2C probable penicillin-binding protein%2C len: 756 aa. Similar to many including: Bacillus subtilis SW:PBPD_BACSU(EMBL:U11882) penicillin-binding protein 4 precursor (624 aa)%2C fasta scores opt: 550 z-score: 456.8 E(): 5.5e-18 28.1%25 identity in 572 aa overlap and Helicobacter pylori TR:O25319(EMBL:AE000573) penicillin-binding protein 1A (659 aa)%2C fasta scores opt: 750 z-score: 619.0 E(): 5.1e-27 31.9%25 identity in 605 aa overlap. Contains Pfam matches to entries PF00912 Transglycosyl%2C Transglycosylase and PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain as well a possible N-terminal signal sequence. gene gene2910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2897 SCO2898 SCO2898 SCE6.35c SCE6.35c 3153389 3153709 - molecular chaperone SCE6.35c%2C sugE%2C molecular chaperone%2C len: 106 aa. Highly similar to several proposed molecular chaperones e.g. Escherichia coli SW:SUGE_ECOLI(EMBL:X69949) SugE (105 aa)%2C fasta scores opt: 394 z-score: 454.4 E(): 7e-18 51.0%25 identity in 104 aa overlap. Contains a Pfam match to entry PF00893 DUF7%2C Integral membrane protein and multiple possible membrane spanning hydrophobic domains. gene gene2911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2898 SCO2899 SCO2899 SCE6.36c SCE6.36c 3153870 3154226 - GroES family molecular chaperone SCE6.36c%2C possible GroES-family molecular chaperone%2C len: 110 aa. Similar to many members of the GroES chaperonin family including: Rhizobium meliloti SW:CH13_RHIME(EMBL:M94191) 10 KD chaperonin C (GroES-C) (101 aa)%2C fasta scores opt: 172 z-score: 231.3 E(): 1.9e-05 33.7%25 identity in 101 aa overlap. Contains 2xPfam matches to entry PF00166 cpn10%2C Chaperonins 10 Kd subunit. gene gene2912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2899 SCO2900 SCO2900 SCE6.37c SCE6.37c 3154250 3154582 - hypothetical protein SCE6.37c%2C possible membrane protein%2C len: 110 aa. Contains a possible membrane spanning hydrophobic domain. gene gene2913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2900 SCO2901 SCO2901 SCE19A.01 SCE19A.01 3154677 3155144 + hypothetical protein SCE19A.01%2C hypothetical protein%2C partial CDS%2C len: >31 aa%3B unknown function%2C similar to members of the alkyl hydroperoxide reductase C/thiol-specific antioxidant family e.g. TR:O53226 (EMBL:AL021185)%2C bcp%2C Mycobacterium tuberculosis bacterioferritin comigratory protein (157 aa)%2C fasta scores%3B opt: 124 z-score: 238.1 E(): 6.2e-06%2C 63.3%25 identity in 30 aa overlap~SCE6.38%2C unknown%2C len: 155 aa. Highly similar to many bacterioferritin co migratory proteins which have no known function e.g. Escherichia coli SW:BCP_ECOLI(EMBL:M63654) bacterioferritin co migratory protein%2C Bcp (156 aa)%2C fasta scores opt: 516 z-score: 621.8 E(): 3.3e-27 51.1%25 identity in 141 aa overlap. Overlaps and extends into CDS SCE19A.01 on the adjoining cosmid. Contains a Pfam match to entry PF00578 AhpC-TSA%2C AhpC/TSA family. gene gene2914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2901 SCO2902 SCO2902 SCE19A.02c SCE19A.02c 3155290 3155892 - deoxyribonucleotide triphosphate pyrophosphatase HAM1-like protein%3B Rec-dependent growth%3B RgdB%3B yggV%3B it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine gene gene2916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2902 SCO2903 SCO2903 SCE19A.03c SCE19A.03c 3155939 3156343 - hypothetical protein SCE19A.03c%2C possible hypothetical protein%2C len: 134 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C so may be a lipoprotein gene gene2917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2903 SCO2904 SCO2904 rph rph 3156501 3157238 - ribonuclease PH RNase PH%3B tRNA nucleotidyltransferase%3B forms hexamers in Bacillus subtilis%3B phosphoroltic 3'-5' exoribonuclease%3B involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs gene gene2918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2904 SCO2905 SCO2905 SCE19A.05c SCE19A.05c 3157315 3157548 - hypothetical protein SCE19A.05c%2C hypothetical protein%2C len: 77 aa%3B unknown function%2C similar to parts of many sugar permeases e.g. TR:P96159 (EMBL:U65013)%2C MalX%2C Vibrio furnissii PTS (phosphoenolpyruvate-dependent sugar phosphotransferase system) permease for glucose (523 aa)%2C fasta scores%3B opt: 217 z-score: 287.9 E(): 1.1e-08%2C 48.1%25 identity in 77 aa overlap. Contains Pfam match to entry PF00367 PTS_EIIB%2C phosphotransferase system%2C EIIB gene gene2919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2905 SCO2906 SCO2906 SCE19A.06 SCE19A.06 3157707 3159002 + PTS transmembrane protein SCE19A.06%2C possible PTS transmembrane component%2C len: 431 aa%3B similar to many PTS (phosphoenolpyruvate-dependent sugar phosphotransferase system) transmembrane and sugar-binding components e.g. TR:Q57071 (EMBL:X93360)%2C GlcA%2C PtsG%2C Staphylococcus carnosus PTS system%2C glucose-specific IIABC component (675 aa)%2C fasta scores%3B opt: 1120 z-score: 1260.6 E(): 0%2C 43.4%25 identity in 431 aa overlap. Similar to the adjacent CDS SCE19A.07%2C possible PTS transmembrane component (416 aa) (4.1%25 identity in 429 aa overlap).The homologous PTS family proteins have a C-terminal extension not present in this CDS. Contains hydrophobic%2C possible membrane-spanning regions gene gene2920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2906 SCO2907 SCO2907 SCE19A.07 SCE19A.07 3159229 3160479 + PTS transmembrane protein SCE19A.07%2C possible PTS transmembrane component%2C len: 416 aa%3B similar to many PTS (phosphoenolpyruvate-dependent sugar phosphotransferase system) transmembrane and sugar-binding components e.g. SW:PTGB_ECOLI (EMBL:J02618)%2C ptsG%2C glcA%2C Escherichia coli PTS system%2C glucose-specific IIBC component (477 aa)%2C fasta scores%3B opt: 1112 z-score: 1244.4 E(): 0%2C 44.7%25 identity in 396 aa overlap. Similar to the adjacent CDS SCE19A.06%2C possible PTS transmembrane component (431 aa) (64.1%25 identity in 429 aa overlap). The homologous PTS family proteins have a C-terminal extension not present in this CDS. Contains hydrophobic%2C possible membrane-spanning regions gene gene2921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2907 SCO2908 SCO2908 SCE19A.08c SCE19A.08c 3160574 3161326 - hypothetical protein SCE19A.08c%2C conserved hypothetical protein%2C len: 250 aa%3B unknown function%2C similar to hypothetical proteins from Mycobacterium leprae%2C Mycobacterium tuberculosis and bacillus subtilis e.g. SW:Y03O_MYCLE (EMBL:U00014) Mycobacterium leprae hypothetical protein (284 aa)%2C fasta scores%3B opt: 642 z-score: 777.3 E(): 0%2C 43.0%25 identity in 256 aa overlap. Similar to SC66T3.08c (EMBL:AL079348) S.coelicolor hypothetical protein (270 aa) (36.4%25 identity in 272 aa overlap) gene gene2922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2908 SCO2909 SCO2909 SCE19A.09 SCE19A.09 3161531 3161698 + hypothetical protein SCE19A.09%2C membrane protein%2C len: 55 aa%3B unknown function%2C improbable CDS suggested by GC frameplot. C-terminus is rich in Arg and Pro. Contains possible hydrophobic membrane spanning region gene gene2923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2909 SCO2910 SCO2910 SCE19A.10c SCE19A.10c 3161747 3162697 - cysteine synthase SCE19A.10c%2C probable cysteine synthase%2C len: 316 aa%3B similar to many e.g. SW:CYSM_ECOLI (EMBL:M32101)%2C CysM%2C Escherichia coli cysteine synthase B (303 aa)%2C fasta scores%3B opt: 776 z-score: 884.3 E(): 0%2C 43.7%25 identity in 293 aa overlap. Highly similar to SW:CYSK_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis probable cysteine synthase (323 aa) (72.4%25 identity in 322 aa overlap). Weak similarity to the N-terminus of SCF43A.11c (EMBL:AL096837) S.coelicolor probable threonine dehydratase (325 aa) (27.2%25 identity in 195 aa overlap). Contains Pfam match to entry PF00291 S_T_dehydratase%2C Pyridoxal-phosphate dependent enzymes and PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site gene gene2924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2910 SCO2911 SCO2911 SCE19A.11c SCE19A.11c 3162704 3162982 - hypothetical protein SCE19A.11c%2C conserved hypothetical protein%2C len: 92 aa%3B unknown function%2C similar to hypothetical proteins from other organisms e.g. SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (93 aa)%2C fasta scores%3B opt: 341 z-score: 451.3 E(): 8.3e-18%2C 57.0%25 identity in 93 aa overlap gene gene2925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2911 SCO2912 SCO2912 SCE19A.12c SCE19A.12c 3163082 3163225 - hypothetical protein SCE19A.12c%2C hypothetical protein%2C len: 47 aa%3B unknown function%2C possible CDS suggested by GC frameplot gene gene2926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2912 SCO2913 SCO2913 SCE19A.13c SCE19A.13c 3163257 3163679 - hypothetical protein SCE19A.13c%2C conserved hypothetical protein%2C len: 140 aa%3B unknown function%2C similar to hypothetical proteins from other organisms e.g. SW:Y03J_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (146 aa)%2C fasta scores%3B opt: 579 z-score: 694.1 E(): 2.5e-31%2C 65.0%25 identity in 140 aa overlap and TR:Q54330 (EMBL:M29166) Streptomyces kasugaensis CDS from Mec+ region (115 aa) (69.8%25 identity in 116 aa overlap) gene gene2927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2913 SCO2914 SCO2914 SCE19A.14c SCE19A.14c 3163847 3165274 - amino acid permease SCE19A.14c%2C probable amino acid permease%2C len: 475 aa%3B similar to many amino acid permeases e.g. SW:ANSP_SALTY (EMBL:U04851)%2C ansP%2C Salmonella typhimurium L-asparagine permease (497 aa)%2C fasta scores%3B opt: 1360 z-score: 1551.0 E(): 0%2C 44.4%25 identity in 455 aa overlap. Similar to SC5F2A.17 (EMBL:AL049587) probable amino acid permease (489 aa) (44.9%25 identity in 465 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and PS00218 Amino acid permeases signature gene gene2928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2914 SCO2915 SCO2915 SCE19A.15c SCE19A.15c 3165626 3166234 - hypothetical protein SCE19A.15c%2C hypothetical protein%2C len: 202 aa%3B similar to SW:Y03H_MYCLE (EMBL:U00014) Mycobacterium leprae hypothetical protein (222 aa)%2C fasta scores%3B opt: 192 z-score: 222.4 E(): 4.7e-05%2C 34.6%25 identity in 188 aa overlap and SW:Y03H_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (218 aa) (32.8%25 identity in 186 aa overlap) gene gene2929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2915 SCO2916 SCO2916 clpS clpS 3166288 3166605 - ATP-dependent Clp protease adaptor protein ClpS involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation%3B binds to the N-terminal domain of the chaperone ClpA gene gene2930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2916 SCO2917 SCO2917 SCE19A.17 SCE19A.17 3166796 3168142 + nicotinate phosphoribosyltransferase catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate gene gene2931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2917 SCO2918 SCO2918 SCE19A.18 SCE19A.18 3168248 3168835 + nicotinamidase SCE19A.18%2C probable nicotinamidase%2C len: 195 aa%3B highly similar to nicotinamidases e.g. TR:Q50575 (EMBL:U59967)%2C PncA%2C Mycobacterium tuberculosis pyrazinamidase/nicotinamidase (186 aa)%2C fasta scores%3B opt: 801 z-score: 921.3 E(): 0%2C 65.6%25 identity in 186 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family gene gene2932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2918 SCO2919 SCO2919 SCE19A.19c SCE19A.19c 3168848 3169192 - hypothetical protein SCE19A.19c%2C hypothetical protein%2C len: 114 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene2933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2919 SCO2920 SCO2920 SCE19A.20c SCE19A.20c 3169339 3171684 - protease SCE19A.20c%2C probable protease%2C len: 781 aa%3B similar to SW:INA_BACTL (EMBL:X55436)%2C Ina%2C Bacillus thuringiensis inhibitor A (a protease) (687 aa)%2C fasta scores%3B opt: 924 z-score: 991.3 E(): 0%2C 32.9%25 identity in 747 aa overlap and TR:O07351 (EMBL:Y00557)%2C PrtV%2C Vibrio cholerae protease precursor (919 aa) (33.2%25 identity in 794 aa overlap). Contains probable N-terminal signal sequence and PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature gene gene2934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2920 SCO2921 SCO2921 SCE19A.21 SCE19A.21 3172118 3172417 + hypothetical protein SCE19A.21%2C membrane protein%2C len: 99 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by GC frameplot and positional base preference. Contains possible hydrophobic membrane spanning regions gene gene2935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2921 SCO2922 SCO2922 SCE19A.22c SCE19A.22c 3172431 3172877 - hypothetical protein SCE19A.22c%2C possible membrane protein%2C len: 148 aa%3B unknown function%2C weakly similar to TR:O34424 (EMBL:AF008220) Bacillus subtilis hypothetical protein (164 aa)%2C fasta scores%3B opt: 137 z-score: 190.5 E(): 0.0028%2C 30.4%25 identity in 135 aa overlap. Weak similarity to adjacent CDS SCE19.23c%2C hypothetical protein (224 aa) (29.1%25 identity in 158 aa overlap). Contains a hydrophobic%2C possible membrane-spanning region gene gene2936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2922 SCO2923 SCO2923 SCE19.23c SCE19.23c 3173314 3173988 - hypothetical protein SCE19.23c%2C membrane protein%2C len: 224 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. The N-terminus is Pro-rich. Weak similarity to adjacent CDS SCE19.22c%2C hypothetical protein (148 aa) (29.1%25 identity in 158 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene2937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2923 SCO2924 SCO2924 SCE19A.24 SCE19A.24 3175140 3175568 + regulator SCE19A.24%2C possible regulator%2C len: 142 aa%3B similar to TR:P95753 (EMBL:D50051)%2C SsgA%2C Streptomyces griseus gene involved in regulation of sporulation and cell division (136 aa)%2C fasta scores%3B opt: 291 z-score: 368.2 E(): 3.6e-13%2C 37.3%25 identity in 126 aa overlap and to SC5F2A.05C (EMBL:AL049587) S. coelicolor regulator (138 aa) (38.5%25 identity in 135 aa overlap) gene gene2938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2924 SCO2925 SCO2925 SCE19A.25c SCE19A.25c 3175582 3177048 - oxidoreductase subunit SCE19A.25c%2C probable oxidoreductase subunit%2C len: 488 aa%3B similar to many e.g. SW:GLCD_ECOLI (EMBL:L43490)%2C GlcD%2C Escherichia coli glycolate oxidase subunit (499 aa)%2C fasta scores%3B opt: 1033 z-score: 1172.9 E(): 0%2C 38.9%25 identity in 460 aa overlap. Also similar to SW:DLD1_YEAST (EMBL:X66052)%2C dld%2C Saccharomyces cerevisiae D-lactate dehydrogenase [cytochrome] precursor (587 aa) (29.4%25 identity in 435 aa overlap). The N-terminus differs from its homologues and an alternative start codon is present at codon 3 gene gene2939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2925 SCO2926 SCO2926 SCE19A.26 SCE19A.26 3177221 3178576 + hypothetical protein SCE19A.26%2C hypothetical protein%2C len: 451 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Alternaive start codons are present at codons 11 and 17. Contains possible N-terminal region signal peptide sequence gene gene2940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2926 SCO2927 SCO2927 SCE19A.27c SCE19A.27c 3178620 3179765 - 4-hydroxyphenylpyruvate dioxygenase SCE19A.27c%2C probable 4-hydroxyphenylpyruvate dioxygenase%2C len: 381 aa%3B highly similar to many e.g. SW:HPPD_STRAW (EMBL:U11864) Streptomyces avermitilis 4-hydroxyphenylpyruvate dioxygenase (380 aa)%2C fasta scores%3B opt: 2347 z-score: 2634.5 E(): 0%2C 91.9%25 identity in 381 aa overlap. Similar to TR:Q9Z4X7 (EMBL:AL035640) S. coelicolor probable 4-hydroxyphenylpyruvic acid dioxygenase (325 aa) (36.4%25 identity in 330 aa overlap) gene gene2941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2927 SCO2928 SCO2928 SCE19A.28 SCE19A.28 3179891 3180382 + transcription regulator AsnC SCE19A.28%2C probable asnC-family transcriptional regulator%2C len: 163 aa%3B similar to SW:ASNC_ECOLI (EMBL:K00826)%2C AsnC%2C Escherichia coli transcriptional activator of asparagine synthetase (152 aa)%2C fasta scores%3B opt: 236 z-score: 296.2 E(): 3.7e-09%2C 31.3%25 identity in 147 aa overlap and to asnC-family regulators. Similar to SC6G9.10 (EMBL:AL079356) S.coelicolor probable AsnC family transcriptional regulator (164 aa) (48.7%25 identity in 156 aa overlap). Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family gene gene2942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2928 SCO2929 SCO2929 SCE19A.29c SCE19A.29c 3180504 3181553 - transposase SCE19A.29c%2C possible transposase%2C len: 349 aa%3B weak similarity to TR:Q48345 (EMBL:M24855) ORF within Anabaena sp. insertion sequence IS891 (402 aa)%2C fasta scores%3B opt: 271 z-score: 327.3 E(): 6.8e-11%2C 25.6%25 identity in 309 aa overlap. Weakly similar to SCH35.10 (EMBL:AL078610) S.coelicolor probable transposase (407 aa) (26.3%25 identity in 342 aa overlap) gene gene2943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2929 SCO2930 SCO2930 SCE19A.30 SCE19A.30 3181757 3182404 + permease membrane protein SCE19A.30%2C probable permease membrane component%2C len: 215 aa%3B similar to components transporters involved in osmoregulation e.g. SW:PROW_BACSU (EMBL:U38418)%2C proW%2C Bacillus subtilis glycine/betaine/L-proline transport system permease (217 aa)%2C fasta scores%3B opt: 413 z-score: 474.7 E(): 4.2e-19%2C 35.1%25 identity in 211 aa overlap. Similar to SCE19A.32%2C probable permease inner membrane component (290 aa) (33.8%25 identity in 207 aa overlap) and to SC9B1.11 (EMBL:AL049727) S.coelicolor probable ABC transport permease (221 aa) (31.3%25 identity in 195 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. May be part of a multicomponent transporter which includes SCE19A.30%2C SCE19A.31%2C SCE19A.32 and SCE19A.33. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component gene gene2944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2930 SCO2931 SCO2931 SCE19A.31 SCE19A.31 3182412 3183686 + ABC transporter ATP-binding protein SCE19A.31%2C probable ABC transporter ATP-binding protein%2C len: 424 aa%3B similar to many%2C including components of transporters involved in osmoregulation e.g. SW:PROV_BACSU (EMBL:U38418)%2C proV%2C Bacillus subtilis glycine/betaine/L-proline transport ATP-binding protein (404 aa)%2C fasta scores%3B opt: 997 z-score: 1092.8 E(): 0%2C 45.7%25 identity in 359 aa overlap. Similar to SC9B1.09 (EMBL:AL049727) S.coelicolor ABC transporter ATP-binding subunit (386 aa) (49.0%25 identity in 365 aa overlap). Contains an approx. 20 aa N-terminal extension absent similar proteins. May be part of a multicomponent transporter which includes SCE19A.30%2C SCE19A.31%2C SCE19A.32 and SCE19A.33. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene2945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2931 SCO2932 SCO2932 SCE19A.32 SCE19A.32 3183683 3184555 + permease membrane protein SCE19A.32%2C probable permease membrane component%2C len: 290 aa%3B similar to many%2C including components of transporters involved in osmoregulation e.g. SW:PROW_BACSU (EMBL:U38418)%2C proW%2C Bacillus subtilis glycine/betaine/L-proline transport system permease (217 aa)%2C fasta scores%3B opt: 429 z-score: 461.7 E(): 2.2e-18%2C 37.7%25 identity in 220 aa overlap. Similar to SCE19A.30%2C probable permease inner membrane component (215 aa) (33.5%25 identity in 209 aa overlap) and SC9B1.11 (EMBL:AL049727) probable ABC transport permease (221 aa) (37.6%25 identity in 186 aa overlap). Contains an approx. 50 aa N-terminal extension absent from similar proteins and hydrophobic%2C possible membrane-spanning regions. May be part of a multicomponent transporter which includes SCE19A.30%2C SCE19A.31%2C SCE19A.32 and SCE19A.33. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene2946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2932 SCO2933 SCO2933 SCE19A.33 SCE19A.33 3184552 3185520 + permease binding-protein component SCE19A.33%2C probable permease binding-protein component%2C len: 322 aa%3B similar to SW:PROX_BACSU (EMBL:U38418)%2C proX%2C Bacillus subtilis glycine/betaine-binding protein precursor (313 aa)%2C fasta scores%3B opt: 300 z-score: 341.4 E(): 1.1e-11%2C 27.5%25 identity in 320 aa overlap and to similar permease components. Similar to SC9B1.12 (EMBL:AL049727) S.coelicolor probable substrate-binding protein (320 aa) (30.4%25 identity in 329 aa overlap). Contains a probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. May be part of a multicomponent transporter which includes SCE19A.30%2C SCE19A.31%2C SCE19A.32 and SCE19A.33 gene gene2947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2933 SCO2934 SCO2934 SCE19A.34c SCE19A.34c 3185545 3186324 - hypothetical protein SCE19A.34c%2C possible hypothetical protein%2C len: 259 aa%3B unknown function%2C similar to parts of hypothetical proteins e.g. TR:O53340 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical protein (340 aa)%2C fasta scores%3B opt: 396 z-score: 436.5 E(): 5.6e-17%2C 34.4%25 identity in 337 aa overlap%2C but with significant indels with respect to that sequence. Very weak similarity to the C-termini of ATP-dependent proteases e.g. SW:LON_CAUCR (EMBL:U56652)%2C lon%2C Caulobacter crescentus ATP-dependent protease (799 aa) (31.5%25 identity in 178 aa overlap). Contains a probable N-terminal signal sequence gene gene2948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2934 SCO2935 SCO2935 SCE19A.35c SCE19A.35c 3186380 3187042 - transcriptional regulator SCE19A.35c%2C probable transcriptional regulator%2C len: 220 aa%3B similar to many e.g. SW:ICLR_ECOLI (EMBL:M31761)%2C IclR%2C Escherichia coli acetate operon repressor (274 aa)%2C fasta scores%3B opt: 206 z-score: 234.8 E(): 9.6e-06%2C 29.2%25 identity in 154 aa overlap. Similar to TR:O05148 (EMBL:U89712)%2C hppR%2C Rhodococcus globerulus regulator of 3-(3-hydroxyphenyl)propionic acid catabolic pathway (206 aa) (44.8%25 identity in 174 aa overlap). Contains probable helix-turn-helix motif at aa 27-48 (Score 1663%2C +4.85 SD) gene gene2949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2935 SCO2936 SCO2936 SCE19A.36c SCE19A.36c 3187344 3189140 - hypothetical protein SCE19A.36c%2C conserved hypothetical protein%2C len: 598 aa%3B unknown function%2C similar to mycobacterial hypothetical proteins SW:Y065_MYCTU (EMBL:Z74697) Mycobacterium tuberculosis hypothetical protein (626 aa)%2C fasta scores%3B opt: 1921 z-score: 2072.6 E(): 0%2C 56.1%25 identity in 567 aa overlap and TR:O33011 (EMBL:Z97369) Mycobacterium leprae hypothetical protein (596 aa) (55.7%25 identity in 566 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene2950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2936 SCO2937 SCO2937 SCE19A.37c SCE19A.37c 3189296 3190747 - transmembrane transport protein SCE56.01c%2C possible transport protein (partial)%2C len: >170 aa%3B similar to TR:AAF11647 (EMBL:AE002045) Deinococcus radiodurans conserved hypothetical protein DR2098%2C 462 aa%3B fasta scores: opt: 330 z-score: 380.0 E(): 9.3e-14%3B 37.4%25 identity in 155 aa overlap and to TR:O69070 (EMBL:AF079900) Streptomyces rimosus tetracycline efflux protein OtrB%2C 563 aa%3B fasta scores: opt: 271 z-score: 312.6 E(): 5.3e-10%3B 34.8%25 identity in 158 aa overlap. Contains possible hydrophobic membrane spanning regions~SCE19A.37c%2C possible transmembrane transport protein%2C partial CDS%2C len: >344 aa%3B weak similarity to transport proteins%2C many hypothetical e.g. TR:Q50392 (EMBL:U40487)%2C lfrA%2C Mycobacterium smegmatis proton antiporter efflux pump (504 aa)%2C fasta scores%3B opt: 220 z-score: 251.9 E(): 1.1e-06%2C 27.8%25 identity in 345 aa overlap. Weak similarity to part of others from S.coelicolor e.g. TR:Q9ZBJ1 (EMBL:AL035161) S.coelicolor probable efflux protein (815 aa) (27.2%25 identity in 345 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene2951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2937 SCO2938 SCO2938 SCE56.02 SCE56.02 3191138 3192148 + oxidoreductase SCE56.02%2C possible oxidoreductase%2C len: 336 aa%3B similar to TR:CAB61562 (EMBL:AL133171) Streptomyces coelicolor aldo/keto reductase (fragment) SCF81.28c%2C 307 aa%3B fasta scores: opt: 1370 z-score: 1572.6 E(): 0%3B 65.2%25 identity in 305 aa overlap and to SW:NORA_ASPFL (EMBL:U32377) Aspergillus flavus norsolorinic acid reductase (EC 1.1.1.-) NorA%2C 388 aa%3B fasta scores: opt: 572 z-score: 659.1 E(): 2.7e-29%3B 32.8%25 identity in 329 aa overlap gene gene2952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2938 SCO2939 SCO2939 SCE56.03c SCE56.03c 3192115 3192897 - hypothetical protein SCE56.03c%2C unknown%2C len: 260 aa gene gene2953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2939 SCO2940 SCO2940 SCE56.04c SCE56.04c 3192991 3195312 - oxidoreductase SCE56.04c%2C possible oxidoreductase%2C len: 773 aa%3B similar to TR:Q9ZBN7 (EMBL:AL034492) Streptomyces coelicolor oxidoreductase SC6C5.08%2C 828 aa%3B fasta scores: opt: 1088 z-score: 1144.8 E(): 0%3B 42.2%25 identity in 782 aa overlap and to SW:XDH_DROPS (EMBL:M33977) Drosophila pseudoobscura xanthine dehydrogenase (EC 1.1.1.204) Xdh%2C 1342 aa%3B fasta scores: opt: 517 z-score: 540.4 E(): 1.1e-22%3B 27.4%25 identity in 762 aa overlap. Contains Pfam match to entry PF01315 Ald_Xan_dh_C%2C Aldehyde oxidase and xanthine dehydrogenase%2C C terminus gene gene2954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2940 SCO2941 SCO2941 SCE56.05c SCE56.05c 3195309 3197630 - hypothetical protein SCE56.05c%2C unknown%2C len: 773 aa%3B similar to C-terminal region of TR:Q9VYQ2 (EMBL:AE003488) Drosophila melanogaster CG2779 protein%2C 1612 aa%3B fasta scores: opt: 651 Z-score: 464.7 E(): 3e-18%3B 31.405%25 identity in 847 aa overlap. High content in proline%2C glycine and alanine. Contains Pfam matches to entries PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains and PF01799 fer2_2%2C [2Fe-2S] binding domain and match to Prosite entry PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature gene gene2955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2941 SCO2942 SCO2942 SCE56.06c SCE56.06c 3197627 3198547 - oxidoreductase SCE59.01c%2C possible oxidoreductase (partial)%2C len: >116 aa%3B similar to N-terminal region of TR:Q9ZBN9 (EMBL:AL034492) Streptomyces coelicolor oxidoreductase subunit SC6C5.06%2C 296 aa%3B fasta scores: opt: 223 z-score: 268.2 E(): 1.6e-07%3B 37.6%25 identity in 93 aa overlap and to TR:P95637 (EMBL:U65440) Rhodopseudomonas palustris 4-hydroxybenzoyl-CoA reductase HbaD subunit%2C 327 aa%3B fasta scores: opt: 193 z-score: 233.2 E(): 1.4e-05%3B 42.6%25 identity in 94 aa overlap~SCE56.06%2C possible oxidoreductase (partial)%2C len: >221 aa%3B similar of TR:Q9ZBN9 (EMBL:AL034492) Streptomyces coelicolor oxidoreductase subunit SC6C5.06%2C 296 aa%3B fasta scores: opt: 393 z-score: 443.2 E(): 2.8e-17%3B 34.7%25 identity in 222 aa overlap and to TR:P95637 (EMBL:U65440) Rhodopseudomonas palustris 4-hydroxybenzoyl-CoA reductase HbaD subunit%2C 327 aa%3B fasta scores: opt: 159 z-score: 184.7 E(): 0.0071%3B 32.1%25 identity in 184 aa overlap gene gene2956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2942 SCO2943 SCO2943 SCE59.02c SCE59.02c 3198763 3200400 - sugar hydrolase SCE59.02c%2C probable sugar hydrolase%2C len: 545 aa%3B similar to TR:Q9ZH39 (EBML:AF072374) Pseudoalteromonas sp. S9 beta-N-acetylglucosaminidase ChiQ%2C 783 aa%3B fasta scores: opt: 1378 z-score: 1537.3 E(): 0%3B 41.6%25 identity in 512 aa overlap and to SW:HEX1_VIBFU (EMBL:U41417) Vibrio furnissii beta-hexosaminidase (EC 3.2.1.52) ExoI%2C 611 aa%3B fasta scores: opt: 1023 z-score: 1142.5 E(): 0%3B 40.0%25 identity in 487 aa overlap. Contains Pfam match to entry PF00728 Glyco_hydro_20%2C Glycosyl hydrolase family 20 gene gene2957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2943 SCO2944 SCO2944 SCE59.03c SCE59.03c 3200405 3201250 - sugar transporter membrane protein SCE59.03c%2C possible sugar transporter membrane protein%2C len: 281 aa%3B similar to TR:CAB59590 (EMBL:AL132662) Streptomyces coelicolor sugar transporter inner membrane protein SCF11.13%2C 285 aa%3B fasta scores: opt: 730 z-score: 883.7 E(): 0%3B 42.1%25 identity in 278 aa overlap and to TR:AAF11008 (EMBL:AE001988) Deinococcus radiodurans ABC transporter%2C permease%2C MalFG family DR1436%2C 283 aa%3B fasta scores: opt: 645 z-score: 781.7 E(): 0%3B 38.2%25 identity in 272 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains possible hydrophobic membrane spanning regions gene gene2958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2944 SCO2945 SCO2945 SCE59.04c SCE59.04c 3201247 3202197 - sugar transporter membrane protein SCE59.04c%2C possible sugar transporter membrane protein%2C len: 316 aa%3B similar to TR:CAB59589 (EMBL:AL132662) Streptomyces coelicolor sugar transporter inner membrane protein SCF11.12%2C 302 aa%3B fasta scores: and to TR:CAB55533 (EMBL:AL117322) Streptomyces coelicolor binding-protein-dependent transport protein SCF1.13%2C 317 aa%3B fasta scores: opt: 527 z-score: 611.6 E(): 1.2e-26%3B 33.1%25 identity in 302 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains also possible hydrophobic membrane spanning regions gene gene2959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2945 SCO2946 SCO2946 SCE59.05c SCE59.05c 3202209 3203507 - sugar transporter sugar-binding protein SCE59.05c%2C possible sugar transporter sugar-binding protein%2C len: 432 aa%3B similar to TR:CAB59588 (EMBL:AL132662) Streptomyces coelicolor sugar transporter sugar-binding protein SCF11.11%2C 422 aa%3B fasta scores: opt: 538 z-score: 581.0 E(): 6e-25%3B 27.0%25 identity in 429 aa overlap and to SW:MALX_STRPN (EMBL:L08611) Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX%2C 423 aa%3B fasta scores: opt: 299 z-score: 325.5 E(): 1e-10%3B 26.0%25 identity in 431 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene2960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2946 SCO2947 SCO2947 SCE59.06c SCE59.06c 3203751 3204044 - hypothetical protein SCE59.06c%2C hypothetical protein%2C len: 97 aa%3B similar to TR:O07209 (EMBL:Z96072) Mycobacterium tuberculosis hypothetical 9.0 kD protein MTCY05A6.29%2C len: 82 aa%3B fasta scores: opt: 200 z-score: 268.5 E(): 1.5e-07%3B 51.6%25 identity in 62 aa overlap gene gene2961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2947 SCO2948 SCO2948 SCE59.07c SCE59.07c 3204066 3204647 - hypothetical protein SCE59.07c%2C hypothetical protein%2C len: 193 aa%3B similar to various hypothetical proteins%2C e.g. TR:P71608 (EMBL:Z80233) Mycobacterium tuberculosis hypothetical 21.8 kD protein CY10H4.38%2C 202 aa%3B fasta scores: opt: 525 z-score: 594.5 E(): 1.1e-25%3B 46.7%25 identity in 182 aa overlap gene gene2962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2948 SCO2949 SCO2949 murA murA 3204872 3206218 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation%3B gram-positive bacteria have 2 copies of MurA which are active gene gene2963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2949 SCO2950 SCO2950 hup hup 3206403 3206684 - DNA-binding protein HU (hs1) SCE59.09%2C hup%2C DNA-binding protein Hu (hs1)%2C len: 93 aa%3B identical to SW:DBH_STRLI (EMBL:AB001381) Streptomyces lividans DNA-binding protein hu (HS1) Hup%2C 93 aa and highly similar to SW:DBH_BACSU (EMBL:X66448) Bacillus subtilis DNA-binding protein II (HB) (HU)%2C 92 aa%3B fasta scores: opt: 237 z-score: 311.2 E(): 6.4e-10%3B 40.9%25 identity in 93 aa overlap. Contains Pfam match to entry PF00216 Bac_DNA_binding%2C Bacterial DNA-binding protein gene gene2964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2950 SCO2951 SCO2951 SCE59.10c SCE59.10c 3207037 3208452 - malate oxidoreductase SCE59.10c%2C probable malate oxidoreductase%2C len: 471 aa%3B similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa%3B fasta scores: opt: 1778 z-score: 1887.0 E(): 0%3B 58.8%25 identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB%2C 759 aa%3B fasta scores: opt: 1092 z-score: 1158.4 E(): 0%3B 46.4%25 identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic%2C Malic enzyme gene gene2965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2951 SCO2952 SCO2952 SCE59.11c SCE59.11c 3208887 3211121 - helicase SCE59.11c%2C possible helicase%2C len: 744 aa%3B similar to TR:O32215 (EMBL:Z99121) Bacillus subtilis YvgS protein%2C 774 aa%3B fasta scores: opt: 346 z-score: 378.5 E(): 1.1e-13%3B 23.1%25 identity in 808 aa overlap and to C-terminal region of SW:UVRD_MYCLE (EMBL:U00016) Mycobacterium leprae probable DNA helicase II homolog (EC 3.6.1.-) UvrD%2C 457 aa%3B fasta scores: opt: 155 z-score: 172.1 E(): 0.036%3B 26.6%25 identity in 241 aa overlap. Contains Pfam match to entry PF01443 Viral_helicase1%2C Viral (Superfamily 1) RNA helicase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible helix-turn-helix motif at residues 638..659 (+2.82 SD) gene gene2966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2952 SCO2953 SCO2953 SCE59.12c SCE59.12c 3211306 3212094 - hypothetical protein SCE59.12c%2C possible membrane protein%2C len: 262 aa%3B similar to TR:CAB63193 (EMBL:AL133469) Streptomyces coelicolor membrane protein SCM10.32%2C 216 aa%3B fasta scores: opt: 204 z-score: 218.0 E(): 9.9e-05%3B 37.2%25 identity in 253 aa overlap. Contains possible hydrophobic membrane spanning region gene gene2967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2953 SCO2954 SCO2954 SCE59.13c SCE59.13c 3212154 3212738 - RNA polymerase sigma factor SigL Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B in M. tuberculosis this protein regulates polyketide synthases and or membrane proteins gene gene2968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2954 SCO2955 SCO2955 SCE59.14c SCE59.14c 3212863 3213453 - hypothetical protein SCE59.14c%2C hypothetical protein%2C len: 196 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB56723 (EMBL:AL121600) Streptomyces coelicolor hypothetical 22.2kD protein SCF76.03%2C 204 aa%3B fasta scores: opt: 357 z-score: 403.5 E(): 4.6e-15%3B 37.4%25 identity in 187 aa overlap gene gene2969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2955 SCO2956 SCO2956 SCE59.15 SCE59.15 3213669 3214232 + hypothetical protein SCE59.15%2C possible integral-membrane protein%2C len: 187 aa%3B similar to TR:CAB66271 (EMBL:AL136519) Streptomyces coelicolor integral-membrane protein SCC57A.03c%2C 199 aa%3B fasta scores: opt: 333 z-score: 376.0 E(): 1.6e-13%3B 47.3%25 identity in 182 aa overlap. Contains possible hydrohpobic membrane spanning regions gene gene2970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2956 SCO2957 SCO2957 SCE59.16c SCE59.16c 3214479 3215057 - hypothetical protein SCE59.16c%2C unknown%2C len: 192 aa gene gene2971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2957 SCO2958 SCO2958 SCE59.17c SCE59.17c 3215125 3216312 - bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane gene gene2972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2958 SCO2959 SCO2959 SCE59.18c SCE59.18c 3216421 3217779 - nitrate extrusion protein SCE59.18c%2C probable nitrate extrusion protein%2C len: 452 aa%3B similar to SW:NARK_ECOLI (EMBL:X15996) Escherichia coli nitrite extrusion protein 1 (nitrite facilitator 1) NarK%2C 463 aa%3B fasta scores: opt: 526 z-score: 590.8 E(): 1.7e-25%3B 39.7%25 identity in 451 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2959 SCO2960 SCO2960 SCE59.19c SCE59.19c 3217912 3218859 - hypothetical protein SCE59.19c%2C possible integral membrane protein%2C len: 315 aa. Contains possible hydrophobic membrane spanning regions and proline rich C-terminal region gene gene2974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2960 SCO2961 SCO2961 SCE59.20c SCE59.20c 3218973 3220178 - hypothetical protein SCE59.20c%2C possible integral membrane protein%2C len: 401 aa%3B similar to TR:Q9XAP7 (EMBL:AL078618) Streptomyces coelicolor integral membrane transferase SC10A7.28c%2C 363 aa%3B fasta scores: opt: 397 z-score: 390.6 E(): 2.4e-14%3B 46.6%25 identity in 369 aa overlap. Contains possible hydrophobic membrane spanning regions and match to Prosite entry PS00038 Myc-type%2C 'helix-loop-helix' dimerization domain signature gene gene2975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2961 SCO2962 SCO2962 SCE59.21c SCE59.21c 3220316 3222520 - bifunctional transferase/deacetylase SCE59.21c%2C possible bi-functional transferase/deacetylase%2C len: 734 aa%3B similar to TR:Q9XAP6 (EMBL:AL078618) Streptomyces coelicolor bi-functional transferase/deacetylase SC10A7.29c%2C 743 aa%3B fasta scores: opt: 2045 z-score: 2233.4 E(): 0%3B 59.5%25 identity in 726 aa overlap and N-terminal region similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) (nodulation protein B) NodB%2C 217 aa%3B fasta scores: opt: 411 z-score: 455.6 E(): 5.8e-18%3B 37.9%25 identity in 198 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet%2C Polysaccharide deacetylase at N-terminal region and Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases at C-terminal region and possible hydrophobic membrane spanning regions gene gene2976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2962 SCO2963 SCO2963 SCE59.22c SCE59.22c 3222520 3224004 - hypothetical protein SCE59.22c%2C membrane protein%2C len: 494 aa. Contains C-terminal region rich in proline and glycine. Contains possible hydrophobic membrane spanning region gene gene2977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2963 SCO2964 SCO2964 SCE59.23c SCE59.23c 3224084 3225055 - LysR family transcriptional regulator SCE59.23c%2C probable lysR-family transcriptional regulator%2C len: 323 aa%3B similar to TR:O88132 (EMBL:AJ006517) Streptomyces lipmanii lysR-type transcriptional regulator StgR%2C 327 aa%3B fasta scores: opt: 551 z-score: 619.3 E(): 4.4e-27%3B 36.6%25 identity in 320 aa overlap and to SW:XAPR_ECOLI (EMBL:X63976) Escherichia coli xanthosine operon regulatory protein XapR%2C 294 aa%3B fasta scores: opt: 364 z-score: 412.4 E(): 1.5e-15%3B 33.6%25 identity in 301 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains possible helix-turn-helix motif at residues 22..43 (+3.25 SD) gene gene2978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2964 SCO2965 SCO2965 SCE59.24 SCE59.24 3225334 3226434 + transporter SCE59.24%2C possible transport protein%2C len: 366 aa%3B similar to TR:CAB59494 (EMBL:AL132648) Streptomyces coelicolor transport protein SCI41.24c%2C 405 aa%3B fasta scores: opt: 513 z-score: 569.7 E(): 2.6e-24%3B 31.1%25 identity in 366 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene2979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2965 SCO2966 SCO2966 smpB smpB 3227050 3227529 - SsrA-binding protein binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes%3B also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site%3B SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus%3B both the tmRNA and SmpB are regulated in cell cycle-dependent manner%3B functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation gene gene2981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2966 SCO2967 SCO2967 SCE59.26c SCE59.26c 3227576 3228700 - carboxy-terminal processing protease SCE59.26c%2C probable carboxy-terminal processing protease precursor%2C len: 374 aa%3B similar to SW:CTPA_BARBA (EMBL:L37094) Bartonella bacilliformis carboxy-terminal processing protease precursor (C-terminal processing protease) CtpA%2C 434 aa%3B fasta scores: opt: 505 z-score: 527.2 E(): 6e-22%3B 30.6%25 identity in 337 aa overlap. Contains Pfam match to entry PF00595 PDZ%2C PDZ domain (Also known as DHR or GLGF) and possible N-terminal region signal peptide sequence gene gene2982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2967 SCO2968 SCO2968 SCE59.27c SCE59.27c 3228832 3229749 - cell division protein SCE59.27c%2C possible cell division protein%2C len: 305 aa%3B similar to TR:P96293 (EMBL:X70031) Mycobacterium tuberculosis FtsX%2C 297 aa%3B fasta scores: opt: 591 z-score: 681.4 E(): 1.5e-30%3B 34.9%25 identity in 304 aa overlap and to SW:FTSX_ECOLI (EMBL:X04398) Escherichia coli cell division protein FtsX%2C 352 aa%3B fasta scores: opt: 194 z-score: 228.3 E(): 2.7e-05%3B 23.4%25 identity in 295 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene2983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2968 SCO2969 SCO2969 ftsE ftsE 3229793 3230482 - cell division ATP-binding protein SCE59.28c%2C ftsE%2C cell division ATP-binding protein%2C len: 229 aa%3B similar to TR:O05779 (EMBL:Z95150) Mycobacterium tuberculosis FtsE%2C 229 aa%3B fasta scores: opt: 908 z-score: 1050.8 E(): 0%3B 62.4%25 identity in 226 aa overlap and to SW:FTSE_ECOLI (EMBL:X04398) Escherichia coli cell division ATP-binding protein FtsE%2C 222 aa%3B fasta scores: opt: 646 z-score: 751.1 E(): 0%3B 49.1%25 identity in 216 aa overlap . Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C two matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and match to Prosite entry PS00211 ABC transporters family signature gene gene2984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2969 SCO2970 SCO2970 SCE59.29 SCE59.29 3230696 3230890 + hypothetical protein SCE59.29%2C membrane protein%2C len: 64 aa. Contains possible hydrophobic membrane spanning region gene gene2985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2970 SCO2971 SCO2971 SCE59.30c SCE59.30c 3231048 3231839 - hypothetical protein SCE59.30c%2C possible hypothetical protein%2C len: 263 aa. Contains the following repeats: 2x(NGGNGNGGNGD) and 18x(PDT). Contains also possible N-terminal region signal peptide sequence gene gene2986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2971 SCO2972 SCO2972 prfB prfB 3232165 3233271 - peptide chain release factor 2 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2%3B in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism%3B this protein is similar to release factor 1 gene gene2987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2972 SCO2973 SCO2973 pkaB pkaB 3233349 3234602 - Ser/Thr protein kinase SCE59.32c%2C pkaB%2C Ser/Thr protein kinase (partial)%2C len: >233 aa%3B identical to C-terminal region of previously sequenced SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr protein kinase PkaB%2C 417 aa. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain. Contains possible hydrophobic membrane spanning region~SCE50.01%2C pkaB%2C Ser/Thr protein kinase%2C len: >222 aa%3B identical to C-terminal region of previously sequenced SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr protein kinase PkaB (EC 2.7.1.-.)%2C 417 aa. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and match to Prosite entry PS00108 Ser/Thr protein kinases active-site signature gene gene2988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2973 SCO2974 SCO2974 pkaA pkaA 3234708 3236339 - Ser/Thr protein kinase SCE50.02c%2C pkaA%2C Ser/Thr protein kinase%2C len: 543 aa%3B identical to previously sequenced SW:PKAA_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr protein kinase PkaA (EC 2.7.1.-)%2C 543 aa. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and match to Prosite entry PS00108 Ser/Thr protein kinases active-site signature gene gene2989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2974 SCO2975 SCO2975 SCE50.03 SCE50.03 3236737 3240774 + hypothetical protein SCE50.03%2C unknown%2C len: 1345 aa. High G+C content (80.71%25) and high also in alanine%2C glycine and proline amino acid residues gene gene2990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2975 SCO2976 SCO2976 SCE50.04c SCE50.04c 3240815 3241444 - hypothetical protein SCE50.04c%2C unknown%2C len: 209 aa gene gene2991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2976 SCO2977 SCO2977 SCE50.05 SCE50.05 3241532 3242731 + hypothetical protein SCE50.05%2C unknown%2C len: 399 aa gene gene2992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2977 SCO2978 SCO2978 SCE50.06 SCE50.06 3242925 3244322 + hypothetical protein SCE50.06%2C possible hypothetical protein%2C len: 465 aa%3B similar to TR:Q55471 (EMBL:D64006) Synechocystis sp. hypothetical 46.5 kD protein%2C 421 aa%3B fasta scores: opt: 788 z-score: 803.7 E(): 0%3B 35.2%25 identity in 386 aa overlap%2C to C-terminal part of SW:MSME_STRMU (EMBL:M77351) Streptococcus mutans multiple sugar binding protein precursor MsmE%2C 420 aa%3B fasta scores: opt: 240 z-score: 249.6 E(): 1.9e-06%3B 25.7%25 identity in 303 aa overlap and to SW:AGLE_RHIME (EMBL:AF045609) Rhizobium meliloti (Sinorhizobium meliloti) alpha-glucosidase-binding periplasmic protein AglE precursor%2C 429 aa%3B fasta scores: opt: 503 Z-score: 522.9 E(): 1.7e-21%3B 35.452%25 identity in 409 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene2993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2978 SCO2979 SCO2979 SCE50.07 SCE50.07 3244399 3245682 + integral membrane transport protein SCE50.07%2C possible integral membrane transport protein%2C len: 427 aa%3B N-terminal and C-terminal regions both similar to TR:Q55472 (EMBL:D64006) Synechocystis sp. membrane bound sugar transport protein%2C 279 aa%3B fasta scores: opt: 307 z-score: 333.7 E(): 3.8e-11%3B 26.5%25 identity in 412 aa overlap. Contains Pfam match in C-terminal region to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match also in C-terminal region to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains possible N-terminal region signal peptide sequence and also possible hydrophobic membrane spanning regions gene gene2994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2979 SCO2980 SCO2980 SCE50.08 SCE50.08 3245679 3246596 + integral membrane transport protein SCE50.08%2C possible integral membrane transport protein%2C len: 305 aa%3B similar to TR:Q55473 (EMBL:D64006) Synechocystis sp. membrane bound sugar transport protein%2C 298 aa%3B fasta scores: opt: 883 z-score: 1001.8 E(): 0%3B 44.5%25 identity in 272 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene2995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2980 SCO2981 SCO2981 SCE50.09 SCE50.09 3246749 3249046 + glycosyl transferase SCE50.09%2C possible glycosyl transferase%2C len: 765 aa%3B similar to TR:CAB66267 (EMBL:AL136518) Streptomyces coelicolor glycosyl transferase (fragment) SCC123.27%2C 743 aa%3B fasta scores: opt: 2334 z-score: 2578.7 E():0%3B 50.4%25 identity in 748 aa overlap and to SW:TAGF_BACSU (EMBL:X15200) Bacillus subtilis teichoic acid biosynthesis protein F%2C TagF%2C 746 aa%3B fasta scores: opt: 319 z-score: 350.8 E(): 4.3e-12%3B 27.9%25 identity in 376 aa overlap. Also similar to Streptomyces coelicolor SCE50.10%2C 736 aa%3B fasta scores: opt: 1837 z-score: 1644.2 E(): 0%3B 45.2%25 identity in 756 aa overlap and SCE50.11%2C 745 aa %3Bfasta scores: opt: 2095 z-score: 1875.1 E(): 0%3B 49.0%25 identity in 764 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene2996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2981 SCO2982 SCO2982 SCE50.10 SCE50.10 3249066 3251276 + glycosyl transferase SCE50.10%2C possible glycosyl transferase%2C len: 736 aa%3B similar to TR:CAB66267 (EMBL:AL136518) Streptomyces coelicolor glycosyl transferase (fragment) SCC123.27%2C 743 aa%3B fasta scores: opt: 2115 z-score: 2498.8 E():0%3B 47.9%25 identity in 746 aa overlap and to SW:TAGF_BACSU (EMBL:X15200) Bacillus subtilis teichoic acid biosynthesis protein F%2C TagF%2C 746 aa%3B fasta scores: opt: 465 z-score: 545.7 E(): 6e-23%3B 30.9%25 identity in 376 aa overlap. Also similar to Streptomyces coelicolor SCE50.09%2C 765 aa%3B fasta scores: opt: 1837 z-score: 1731.8 E(): 0%3B 44.8%25 identity in 754 aa overlap and SCE50.11%2C 745 aa%3B fasta scores: opt: 1407 z-score: 1326.5 E(): 0%3B 43.7%25 identity in 746 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene2997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2982 SCO2983 SCO2983 SCE50.11 SCE50.11 3251284 3253521 + glycosyl transferase SCE50.11%2C possible glycosyl transferase%2C len: 745 aa%3B similar to TR:CAB66267 (EMBL:AL136518) Streptomyces coelicolor glycosyl transferase (fragment) SCC123.27%2C 743 aa%3B fasta scores: opt: 2355 z-score: 2721.3 E(): 0%3B 51.2%25 identity in 732 aa overla and to SW:TAGF_BACSU (EMBL:X15200) Bacillus subtilis teichoic acid biosynthesis protein F%2C TagF%2C 746 aa%3B fasta scores: opt: 553 z-score: 636.4 E(): 5.3e-28%3B 28.2%25 identity in 432 aa overlap. Also similar to Streptomyces coelicolor SCE50.09%2C 765 aa%3B fasta scores: opt: 2095 z-score: 1969.9 E(): 0%3B 48.7%25 identity in 764 aa overlap and SCE50.10%2C 736 aa%3B fasta scores: opt: 1407 z-score: 1323.0 E(): 0%3B 43.7%25 identity in 746 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene2998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2983 SCO2984 SCO2984 SCE50.12 SCE50.12 3253518 3254849 + hypothetical protein SCE50.12%2C possible integral membrane protein%2C len: 443 aa. Contains possible hydrophobic membrane spanning regions and possible N-terminal region signal peptide sequence gene gene2999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2984 SCO2985 SCO2985 SCE50.13 SCE50.13 3254989 3256542 + hypothetical protein SCE50.13 possible integral membrane protein%2C len: 517 aa. Contains possible hydrophobic membrane spanning regions gene gene3000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2985 SCO2986 SCO2986 SCE50.14c SCE50.14c 3256564 3256977 - hypothetical protein SCE50.14c%2C hypothetical protein%2C len: 137 aa%3B similar to TR:CAB62728 (EMBL:AL133423) Streptomyces coelicolor hypothetical 14.2 kD protein SC4A7.24c%2C 139 aa%3B fasta scores: opt: 533 z-score: 620.7 E(): 4e-27%3B 60.9%25 identity in 133 aa overlap gene gene3001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2986 SCO2987 SCO2987 SCE50.15 SCE50.15 3257116 3257622 + regulatory protein SCE50.15%2C possible regulatory protein%2C len: 168 aa%3B similar to SW:HPCR_ECOLI (EMBL:S56952) Escherichia coli homoprotocatechuate degradative operon repressor HpcR%2C 148 aa%3B fasta scores: opt: 151 z-score: 195.2 E(): 0.002%3B 27.9%25 identity in 136 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene3002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2987 SCO2988 SCO2988 galE2 galE2 3257700 3258680 + UDP-glucose 4-epimerase SCE50.16%2C galE2%2C UDP-glucose 4-epimerase%2C len: 326 aa%3B highly similar to SW:EXOB_AZOBR (EMBL:Z25478) Azospirillum brasilense UDP-glucose 4-epimerase (EC 5.1.3.2) ExoB%2C 348 aa%3B fasta scores: opt: 885 z-score: 970.7 E(): 0%3B 46.4%25 identity in 319 aa overlap and to SW:GALE_STRLI (EMBL:M18953) Streptomyces lividans UDP-glucose 4-epimerase (EC 5.1.3.2) GalE%2C 329 aa%3B fasta scores: opt: 793 z-score: 870.9 E(): 0%3B42.7%25 identity in 328 aa overlap. Contains Pfam match to entry PF01370 Epimerase%2C NAD dependent epimerase/dehydratase family gene gene3003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2988 SCO2989 SCO2989 SCE50.17c SCE50.17c 3258693 3259130 - hypothetical protein SCE50.17c%2C possible integral membrane protein%2C len: 145 aa%3B similar to TR:Q9X8C2 (EMBL:AL049763) Streptomyces coelicolor hypothetical 13.0 kD protein SCE36.09%2C 114 aa%3B fasta scores: opt: 256 z-score: 321.6 E(): 1.8e-10%3B 53.5%25 identity in 71 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene3004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2989 SCO2990 SCO2990 SCE50.18c SCE50.18c 3259127 3259738 - hypothetical protein SCE50.18c%2C hypothetical protein%2C len: 203 aa%3B similar to TR:Q9Z552 (EMBL:AL03521) Streptomyces coelicolor hypothetical 17.8 kD protein%2C 162 aa%3B fasta scores: opt: 203 z-score: 257.9 E(): 6.4e-07%3B 29.7%25 identity in 165 aa overlap and to TR:Q9AK06 (EMBL:AL512944) Streptomyces coelicolor hypothetical protein SC8D11.13%2C 194 aa%3B fasta scores: opt: 588 Z-score: 704.3 E(): 1.4e-31%3B 49.735%25 identity in 189 aa overlap gene gene3005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2990 SCO2991 SCO2991 SCE50.19c SCE50.19c 3259735 3260538 - hypothetical protein SCE50.19c%2C unknown%2C len: 267 aa gene gene3006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2991 SCO2992 SCO2992 SCE50.20c SCE50.20c 3260554 3261048 - acetyltransferase SCE50.20c%2C probable acetyltransferase%2C len: 164 aa%3B similar to TR:O66161 (EMBL:AB005901) Streptomyces kasugaensis kasugamycin acetyltransferase KAC338%2C 141 aa%3B fasta scores: opt: 756 z-score: 933.2 E(): 0%3B 76.8%25 identity in 142 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene3007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2992 SCO2993 SCO2993 SCE50.21 SCE50.21 3261047 3261601 + hypothetical protein SCE50.21%2C unknown%2C len: 184 aa gene gene3008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2993 SCO2994 SCO2994 SCE99.01c SCE99.01c 3261649 3262339 - TetR family transcriptional regulator SCE99.01c%2C probable tetR-family transcriptional regulator (fragment)%2C len: >230 aa%3B similar to TR:Q54288 (EMBL:X86780) Streptomyces hygroscopicus regulator of antibiotic transport complexes ORFY%2C 204 aa%3B fasta scores: opt: 427 z-score: 493.1 E(): 6.3e-20%3B 45.5%25 identity in 167 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 71..92 (+4.56 SD) gene gene3009 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2994 SCO2995 SCO2995 SCE99.02 SCE99.02 3262446 3263402 + ABC transporter SCE99.02%2C possible ABC transporter integral membrane protein%2C len: 318 aa%3B similar to TR:Q9X7V2 (EMBL:AL049485) Streptomyces coelicolor ABC transporter membrane component SC6A5.06%2C 309 aa%3B fasta scores: opt: 1393 z-score: 1546.8 E(): 0%3B 69.0%25 identity in 300 aa overlap and to SW:RFA1_KLEPN (EMBL:L31775) Klebsiella pneumoniae O-antigen export system permease RfbA%2C 259 aa%3B fasta scores: opt: 327 z-score: 370.8 E(): 4.1e-13%3B 26.6%25 identity in 199 aa overlap. Contains Pfam match to entry PF01061 ABC2_membrane%2C ABC-2 type transporter and possible hydrophobic membrane spanning regions gene gene3010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2995 SCO2996 SCO2996 SCE99.03 SCE99.03 3263440 3264306 + ABC transporter ATP-binding protein SCE99.03%2C possible ABC transporter ATP-binding protein%2C len: 288 aa%3B similar to SW:RFB1_KLEPN (EMBL:L31775) Klebsiella pneumoniae O-antigen export system ATP-binding protein RfbB%2C 246 aa%3B fasta scores: opt: 550 z-score: 504.2 E(): 1.5e-20%3B 40.2%25 identity in 209 aa overlap and to TR:Q9X7V3 (EMBL:AL049085) Streptomyces coelicolor ABC transporter ATP-binding component SC6A5.07%2C 253 aa%3B fasta scores: opt: 1381 z-score: 963.7 E(): 0%3B 82.5%25 identity in 251 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene3011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2996 SCO2997 SCO2997 SCE99.04 SCE99.04 3264435 3266675 + transferase SCE99.04%2C possible transferase%2C len: 746 aa%3B similar to TR:Q9L053 (EMBL:AL163672) Streptomyces coelicolor glycosyl transferase SCE50.10%2C 736 aa%3B fasta scores: opt: 1826 z-score: 2036.2 E(): 0%3B 46.9%25 identity in 749 aa overlap gene gene3012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2997 SCO2998 SCO2998 SCE99.05 SCE99.05 3266672 3268393 + transferase SCE99.05%2C possible transferase%2C len: 573 aa%3B N-terminal domain similar to TR:AAG01876 (EMBL:AF292031) Mesorhizobium huakuii glucosyltransferase Exo1%2C 340 aa%3B fasta scores: opt: 312 z-score: 366.8 E(): 6.8e-13%3B 30.3%25 identity in 337 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene3013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2998 SCO2999 SCO2999 SCE33.01c SCE33.01c 3268611 3273572 - hypothetical protein SCE33.01c%2C hypothetical protein (fragment)%2C len: >187 aa%3B similar to TR:Q9X7B2 (EMBL:AL049913) Mycobacterium leprae hypothetical 177.9 kD protein MCLB1610.10%2C 1622 aa%3B fasta scores: opt: 154 z-score: 172.5 E(): 0.038%3B 29.7%25 identity in 155 aa overlap~SCE99.06c%2C conserved hypothetical protein (fragment)%2C len: >1515 aa%3B similar to TR:AAG06456 (EMBL:AE004731) Pseudomonas aeruginosa conserved hypothetical protein PA3068%2C 1620 aa%3B fasta scores: opt: 4170 z-score: 4589.7 E(): 0%3B 46.3%25 identity in 1521 aa overlap gene gene3014 http://www.ncbi.nlm.nih.gov/gene/?term=SCO2999 SCO3000 SCO3000 SCE33.02c SCE33.02c 3274075 3274746 - phosphatase SCE33.02c%2C possible phosphatase%2C len: 223 aa%3B similar to TR:AAF42165 (EMBL:AE002532) Neisseria meningitidis phosphoglycolate phosphatase%2C NMB1830%2C 219 aa%3B fasta scores: opt: 221 z-score: 270.1 E(): 1.4e-07%3B 28.4%25 identity in 218 aa overlap and to SW:GPH_RHOCA (EMBL:U23145) Rhodobacter capsulatus phosphoglycolate phosphatase (EC 3.1.3.18) CbbZ%2C 219 aa%3B fasta scores: opt: 158 z-score: 196.2 E(): 0.0018%3B 25.4%25 identity in 189 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene3015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3000 SCO3001 SCO3001 SCE33.03c SCE33.03c 3274805 3275308 - hypothetical protein SCE33.03c%2C hypothetical protein%2C len: 167 aa%3B similar to TR:O0587 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 17.8 kD protein MTCY20B11.06c%2C 169 aa%3B fasta scores: opt: 415 z-score: 473.1 E(): 6.8e-19%3B 49.1%25 identity in 171 aa overlap gene gene3016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3001 SCO3002 SCO3002 SCE33.04c SCE33.04c 3275287 3275574 - hypothetical protein SCE33.04c%2C unknown%2C len: 95 aa gene gene3017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3002 SCO3003 SCO3003 SCE33.05c SCE33.05c 3275599 3275946 - hypothetical protein SCE33.05c%2C unknown%2C len: 115 aa. High content in glycine and proline amino acid residues and also high %25 G+C (80.57%25) gene gene3018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3003 SCO3004 SCO3004 SCE33.06 SCE33.06 3276479 3276748 + hypothetical protein SCE33.06%2C unknown%2C len: 89 aa. High content in arginine amino acid residues and also high %25 G+C (77.4%25) gene gene3019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3004 SCO3005 SCO3005 azi azi 3276877 3279720 - preprotein translocase subunit SecA functions in protein export%3B can interact with acidic membrane phospholipids and the SecYEG protein complex%3B binds to preproteins%3B binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein%3B ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane%3B additional proteins SecD/F/YajC aid SecA recycling%3B exists in an equilibrium between monomers and dimers%3B may possibly form higher order oligomers%3B proteins in this cluster correspond SecA1%3B SecA2 is not essential and seems to play a role in secretion of a subset of proteins gene gene3020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3005 SCO3006 SCO3006 SCE33.08 SCE33.08 3280002 3280577 + acetyltransferase SCE33.08%2C possible acetyltransferase%2C len: 191 aa%3B similar to TR:Q9Z576 (EMBL:AL035569) Streptomyces coelicolor acetyltransferase SC8D9.15%2C 194 aa%3B fasta scores: opt: 212 z-score: 283.0 E(): 2.6e-08%3B 40.5%25 identity in 84 aa overlap. Contains possible hydrophobic membrane spanning region gene gene3021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3006 SCO3007 SCO3007 SCE33.09 SCE33.09 3280662 3281837 + hypothetical protein SCE33.09%2C hypothetical protein%2C len: 391 aa%3B similar to TR:AAF11622 (EMBL:AE002043) Deinococcus radiodurans conserved hypothetical protein DR2072%2C 360 aa%3B fasta scores: opt: 300 z-score: 355.4 E(): 2.5e-12%3B 30.1%25 identity in 362 aa overlap and to TR:Q9HZZ9 (EMBL:AE004711) Pseudomonas aeruginosa hypothetical protein PA2844%2C 402 aa%3B fasta scores: opt: 629 Z-score: 729.7 E(): 5.2e-33%3B 40.415%25 identity in 386 aa overlap gene gene3022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3007 SCO3008 SCO3008 SCE33.10c SCE33.10c 3281872 3282630 - two-component system response regulator SCE33.10c%2C probable two-component system response regulator%2C len: 252 aa%3B similar to TR:AAF10563 (EMBL:AE001951) Deinococcus radiodurans DNA-binding response regulator DR0987%2C 239 aa%3B fasta scores: opt: 576 z-score: 658.2 E(): 3.3e-29%3B 44.0%25 identity in 218 aa overlap and to various Streptomyces coelicolor two-component response regulators%2C e.g. TR:CAB59507 (EMBL:AL132648) SCI41.37%2C 223 aa%3B fasta scores: opt: 622 z-score: 571.0 E(): 2.8e-26%3B 47.2%25 identity in 214 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains also possible helix-turn-helix motif at residues 204..225 (+5.13 SD) gene gene3023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3008 SCO3009 SCO3009 SCE33.11c SCE33.11c 3282859 3283623 - hypothetical protein SCE33.11c%2C hypothetical protein%2C len: 254 aa%3B similar to TR:O05886 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 24.5 kD protein MTCY20B11.16c%2C 214 aa%3B fasta scores: opt: 487 z-score: 551.0 E(): 3.1e-23%3B 47.6%25 identity in 210 aa overlap gene gene3024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3009 SCO3010 SCO3010 SCE33.12c SCE33.12c 3283865 3284812 - hypothetical protein SCE33.12c%2C hypothetical protein%2C len: 315 aa%3B similar to TR:O05887 (EMBL:Z95121) hypothetical 22.5 kD protein MTCY20B11.17c%2C 213 aa%3B fasta scores: opt: 189 z-score: 191.8 E(): 0.0032%3B 36.8%25 identity in 228 aa overlap gene gene3025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3010 SCO3011 SCO3011 SCE33.13c SCE33.13c 3284985 3286832 - lipoprotein LpqB SCE33.13c%2C possible lipoprotein%2C len: 615 aa%3B similar to TR:O05889 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 61.2 kD protein MTCY20B11.19c%2C 583 aa%3B fasta scores: opt: 228 z-score: 243.7 E(): 4.1e-06%3B 25.5%25 identity in 624 aa overlap. Contains properly located match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3011 SCO3012 SCO3012 SCE33.14c SCE33.14c 3286822 3288888 - two-component system histidine kinase SCE33.14c%2C probable two-component system histidine kinase%2C len: 688 aa%3B similar to TR:O05890 (EMBL:Z95121) Mycobacterium tuberculosis MtrB%2C 567 aa%3B fasta scores: opt: 1355 z-score: 1302.5 E(): 0%3B 48.9%25 identity in 515 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-) fasta scores: opt: 560 z-score: 542.0 E(): 9.8e-23%3B 31.1%25 identity in 460 aa overlap. Contains Pfam matches to entries PF00672 DUF5%2C Domain found in bacterial signal proteins and PF00512 signal%2C Histidine kinase. Contains possible hydrophobic membrane spanning regions gene gene3027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3012 SCO3013 SCO3013 SCE33.15c SCE33.15c 3288890 3289579 - two-component system response regulator SCE33.15c%2C probable two-component system response regulator%2C len: 229 aa%3B similar to TR:Q50447 (EMBL:Z95121) Mycobacterium tuberculosis MtrA%2C 228 aa%3B fasta scores: opt: 1141 z-score: 1397.7 E(): 0%3B 74.9%25 identity in 227 aa overlap%2C to SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1%2C 225 aa%3B fasta scores: opt: 698 z-score: 858.5 E(): 0%3B 47.7%25 identity in 220 aa overlap and to many other S. coelicolor two-component system response regulators%2C e.g. TR: CAB77324(EMBL:AL160331) response regulator SCD8A.03%2C 223 aa%3B fasta scores: opt: 695 z-score: 745.0 E(): 0%3B 50.2%25 identity in 223 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene3028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3013 SCO3014 SCO3014 SCE33.16c SCE33.16c 3289584 3290726 - translation initiation factor SCE33.16c%2C possible translation initiation factor%2C len: 380 aa%3B similar to TR:Q9ZUG4 (EMBL:AC005970) Arabidopsis thaliana translation initiation factor EIF-2B alpha subunit T6P5.3%2C 365 aa%3B fasta scores: opt: 631 z-score: 658.4 E(): 3.2e-29%3B 37.6%25 identity in 338 aa overlap. Contains Pfam match to entry PF01008 IF-2B%2C Initiation factor 2 subunit family gene gene3029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3014 SCO3015 SCO3015 SCE33.17 SCE33.17 3290867 3292255 + hypothetical protein SCE33.17%2C possible integral membrane protein%2C len: 462 aa%3B similar to TR:O69657 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 46.4 kD protein MTV025.037%2C 451 aa%3B fasta scores: opt: 730 z-score: 506.4 E(): 9.5e-21%3B 38.1%25 identity in 412 aa overlap. Contains possible hydrophobic membrane spanning regions and high content in proline and glycine amino acid residues gene gene3030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3015 SCO3016 SCO3016 SCE33.18 SCE33.18 3292317 3293012 + hypothetical protein SCE33.18%2C possible integral membrane protein%2C len: 231 aa%3B similar to TR:O69658 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 23.8 kD protein MTV025.038%2C 217 aa%3B fasta scores: opt: 419 z-score: 493.8 E(): 4.8e-20%3B 36.0%25 identity in 211 aa overlap. Contains possible hydrophobic membrane spanning region gene gene3031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3016 SCO3017 SCO3017 SCE33.19 SCE33.19 3293063 3294226 + hypothetical protein SCE33.19%2C possible hypothetical protein%2C len: 387 aa%3B similar to TR:O69659 (EMBL::AL022121) Mycobacterium tuberculosis hypothetical 355 kD protein MTV025.039%2C 333 aa%3B fasta scores: opt: 481 z-score: 542.0 E(): 9.9e-23%3B 36.6%25 identity in 358 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3017 SCO3018 SCO3018 SCE33.20 SCE33.20 3294226 3295215 + regulatory protein SCE33.20%2C possible regulatory protein%2C len: 329 aa%3B similar to TR:O69660 (EMBL:AL022121) Mycobacterium tuberculosis regulatory protein MTV025.040%2C 358 aa%3B fasta scores: opt: 1523 z-score: 1708.1 E(): 0%3B 70.9%25 identity in 330 aa overlap and to TR:CAA22801 (EMBL:AL035212) Streptomyces coelicolor regulatory protein%2C SC9B2.21c%2C 332 aa%3B fasta scores: opt: 956 z-score: 937.8 E(): 0%3B 50.7%25 identity in 306 aa overlap. Contains Pfam match to entry PF01078 Mg_chelatase%2C Magnesium chelatase%2C subunit ChlI gene gene3033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3018 SCO3019 SCO3019 SCE33.21 SCE33.21 3295215 3296525 + lipoprotein SCE33.21%2C possible lipoprotein%2C len: 436 aa%3B similar to TR:O69661 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 47.7 kD protein MTV025.041%2C 440 aa%3B fasta scores: opt: 875 z-score: 982.3 E(): 0%3B 56.3%25 identity in 448 aa overlap. Contains Pfam match to entry PF01882 DUF58%2C Protein of unknown function and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site also contains possible N-terminal region signal peptide sequence gene gene3034 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3019 SCO3020 SCO3020 SCE34.01c SCE34.01c 3302319 3303326 - hypothetical protein SCE34.01c%2C possible integral membrane protein%2C len: 335 aa%3B similar to TR:O69662 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 35.5 kD protein MTV025.042c%2C 330 aa%3B fasta scores: opt: 1119 z-score: 1285.3 E(): 0%3B 51.8%25 identity in 334 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3020 SCO3021 SCO3021 SCE34.02 SCE34.02 3303453 3304409 + hypothetical protein SCE34.02%2C possible integral membrane protein%2C len: 318 aa%3B similar to TR:O69663 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 33.2 kD protein MTV025.043%2C 310 aa%3B fasta scores: opt: 734 z-score: 602.4 E(): 4.3e-26%3B 42.9%25 identity in 319 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3021 SCO3022 SCO3022 SCE34.03c SCE34.03c 3304430 3305044 - hypothetical protein SCE34.03c%2C unknown%2C len: 204 aa gene gene3040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3022 SCO3023 SCO3023 sahH sahH 3305155 3306612 - adenosylhomocysteinase catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine gene gene3041 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3023 SCO3024 SCO3024 SCE34.05c SCE34.05c 3306886 3307866 - transporter SCE34.05c%2C possible transport protein%2C len: 326 aa%3B similar to TR:AAF26917 (EMBL:AF210843) Sorangium cellulosum transport protein%2C 305 aa%3B fasta scores: opt: 629 z-score: 707.7 E(): 5.9e-32%3B 37.8%25 identity in 299 aa overlap. Contains Pfam match to entry PF01545 Cation_efflux%2C Cation efflux family and possible hydrophobic membrane spanning regions gene gene3042 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3024 SCO3025 SCO3025 manA manA 3307981 3309132 - mannose-6-phosphate isomerase SCE34.06c%2C manA%2C mannose-6-phosphate isomerase%2C len: 383 aa%3B similar to SW:MANA_ECOLI (EMBL:M15380) Escherichia coli mannose-6-phosphate isomerase (EC 5.3.1.8) ManA%2C 391 aa%3B fasta scores: opt: 912 z-score: 1055.7 E(): 0%3B 40.9%25 identity in 391 aa overlap. Contains Pfam match to entry PF01238 PMI_typeI%2C Phosphomannose isomerase type I and match to Prosite entry S00965 Phosphomannose isomerase type I signature 1 gene gene3043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3025 SCO3026 SCO3026 SCE34.07c SCE34.07c 3309183 3310310 - hypothetical protein SCE34.07c%2C hypothetical protein%2C len: 375 aa%3B similar to TR:O05899 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 35.3 kD protein RV3256c%2C 346 aa%3B fasta scores: opt: 171 z-score: 187.3 E(): 0.0057%3B 31.1%25 identity in 376 aa overlap gene gene3044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3026 SCO3027 SCO3027 SCD84.08c SCD84.08c 3310398 3310568 - hypothetical protein SCD84.08c%2C hypothetical protein%2C len: 56 aa%3B similar to SW:YCAR_ECOLI (EMBL:AE000193) Escherichia coli%2C hypotheical 6.9 kD protein in MsbA-KdsB intergenic region YcaR%2C 60 aa%3B fasta scores: opt: 159 z-score: 238.1 E(): 8.3e-06%3B 55.1%25 identity in 49 aa overlap gene gene3045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3027 SCO3028 SCO3028 manB manB 3310820 3312184 - phosphomannomutase converts mannose-6-phosphate to mannose-1-phosphate%3B the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells gene gene3046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3028 SCO3029 SCO3029 SCE34.10c SCE34.10c 3312276 3313892 - L-lactate permease SCE34.10c%2C possible L-lactate permease%2C len: 538 aa%3B similar to SW:LLDP_ECOLI (EMBL:L13970) Escherichia coli L-lactate permease LldP%2C 551 aa%3B fasta scores: opt: 825 z-score: 909.1 E(): 0%3B 40.0%25 identity in 552 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3029 SCO3030 SCO3030 SCE34.11c SCE34.11c 3314042 3314464 - hypothetical protein SCE34.11c%2C hypothetical protein%2C len: 140 aa%3B similar to TR:O53351 (EMBL:AL021840) Mycobacterium tuberculosis hypothetical 16.8 kD protein MTV015.30c%2C 163 aa%3B fasta scores: opt: 353 z-score: 430.4 E(): 1.6e-16%3B 48.3%25 identity in 147 aa overlap gene gene3048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3030 SCO3031 SCO3031 SCE34.12 SCE34.12 3314858 3315211 + hypothetical protein SCE34.12%2C hypothetical protein%2C len: 117 aa%3B similar to TR:AAD4708 (EMBL:AF164439) Mycobacterium smegmatis hypothetical 6.0 kD protein (fragment)%2C 54 aa%3B fasta scores: opt: 184 z-score: 255.1 E(): 9.4e-07%3B 46.3%25 identity in 54 aa overlap gene gene3049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3031 SCO3032 SCO3032 SCE34.13c SCE34.13c 3315241 3316761 - hypothetical protein SCE34.13c%2C possible hypothetical protein%2C len: 506 aa. Contains possible N-terminal region signal peptide sequence gene gene3050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3032 SCO3033 SCO3033 SCE34.14c SCE34.14c 3316758 3320564 - integral membrane regulatory protein SCE34.14c%2C possible integral membrane regulatory protein%2C len: 1268 aa%3B N-terminal region identical to previously sequenced TR:Q53964 (EMBL:X62287) Streptomyces coelicolor regulatory protein WhiB%2C 914 aa and highly similar to TR:Q53785 (EMBL:L22864) Streptomyces aureofaciens transmembrane protein WhiB2%2C 1219 aa%3B fasta scores: opt: 4895 z-score: 4433.4 E(): 0%3B 62.0%25 identity in 1267 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3033 SCO3034 SCO3034 SCE34.15c SCE34.15c 3320753 3321016 - sporulation regulatory protein SCE34.15c%2C whiB%2C sporulation regulatory protein%2C len: 87 aa%3B identical to previously sequenced TR:Q53963 (EMBL:X62287) Streptomyces coelicolor regulatory protein WhiB%2C 87 aa also highly similar to TR:Q9XAL5 (EMBL:AL079355) Streptomyces coelicolor probable transcriptional regulator SC4C6.25%2C 81 aa%3B fasta scores: opt: 336 z-score: 473.5 E(): 7.3e-21%3B 61.1%25 identity in 72 aa overlap gene gene3052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3034 SCO3035 SCO3035 SCE34.16 SCE34.16 3321701 3322195 + hypothetical protein SCE34.16%2C hypothetical protein%2C len: 164 aa%3B similar to TR:O53413 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 20.6 kD protein MTV017.18%2C 188 aa%3B fasta scores: opt: 251 z-score: 321.5 E(): 1.9e-10%3B 39.6%25 identity in 154 aa overlap gene gene3053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3035 SCO3036 SCO3036 SCE34.17 SCE34.17 3322266 3323225 + 2-phospho-L-lactate transferase catalyzes the formation of the L-lactyl phosphodiester of 7%2C8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7%2C8-didemethyl-8-hydroxy-5-deazariboflavin (FO) gene gene3054 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3036 SCO3037 SCO3037 SCE34.18 SCE34.18 3323222 3324553 + F420-0--gamma-glutamyl ligase catalyzes the addition of gamma linked glutamate to 7%2C8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0) gene gene3055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3037 SCO3038 SCO3038 SCE34.19 SCE34.19 3324630 3325610 + hypothetical protein SCE34.19%2C hypothetical protein%2C len: 326 aa%3B similar to TR:P96819 (EMB:LZ92770) Mycobacterium tuberculosis hypothetical 33.0 kD protein MTCI5.16%2C 308 aa%3B fasta scores: opt: 902 z-score: 980.1 E(): 0%3B 51.2%25 identity in 287 aa overlap and C-terminal region presents low similarity to SW:3MGA_BACSU (EMBLD14465:) Bacillus subtilis DNA-3-methyladenine glycosylase (EC 3.2.2.21) AlkA%2C 303 aa%3B fasta scores: opt: 146 z-score: 166.1 E(): 0.086%3B 23.6%25 identity in 208 aa overlap gene gene3056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3038 SCO3039 SCO3039 SCE34.20c SCE34.20c 3325773 3326855 - nucleotide phosphorylase SCE34.20c%2C probable nucleotide phosphorylase%2C len: 360 aa%3B similar to SW:MPG1_YEAST (EMBL:U19608) Saccharomyces cerevisiae mannose-1-phosphate guanyltransferase (EC 2.7.7.13) Mpg1%2C 361 aa%3B fasta scores: opt: 570 z-score: 625.6 E(): 2.2e-27%3B 30.8%25 identity in 347 aa overlap. Contains Pfam matches to entries PF00483 NTP_transferase%2C Nucleotidyl transferase and 3x PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) gene gene3057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3039 SCO3040 SCO3040 SCE34.21c SCE34.21c 3326959 3328209 - hypothetical protein SCE34.21c%2C possible hypothetical protein%2C len: 416 aa%3B similar to TR:CAB51271 (EMBL:AL096872) Streptomyces coelicolor hypothetical 31.9 kD protein SC5F7.14c%2C 308 aa%3B fasta scores: opt: 646 z-score: 629.8 E(): 1.3e-27%3B 40.5%25 identity in 304 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and possible N-terminal region signal peptide sequence gene gene3058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3040 SCO3041 SCO3041 SCE34.22 SCE34.22 3328322 3329113 + hypothetical protein SCE34.22%2C hypothetical protein%2C len: 263 aa%3B similar to TR:P96873 (EMBL:Z92771) Mycobacterium tuberculosis hypothetical 23.7 kD protein%2C 229 aa%3B fasta scores: opt: 442 z-score: 490.8 E(): 7.1e-20%3B 40.1%25 identity in 242 aa overlap gene gene3059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3041 SCO3042 SCO3042 SCE34.23 SCE34.23 3329406 3330596 + transcriptional regulator SCE34.23%2C possible transcriptional regulator%2C len: 396 aa%3B similar to TR:O86796 (EMBL:AL031317) Streptomyces coelicolor transcriptional regulator SC6G4.33%2C 360 aa%3B fasta scores: opt: 792 z-score: 875.9 E(): 0%3B 43.3%25 identity in 363 aa overlap%2C to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA%2C 770 aa%3B fasta scores: opt: 686 z-score: 739.2 E(): 0%3B 41.3%25 identity in 283 aa overlap%2C to Streptomyces coelicolor SCE34.26%2C 507 aa%3B fasta scores: opt: 709 z-score: 659.1 E(): 3.4e-31%3B 36.4%25 identity in 357 aa overlap%2C StE34.25%2C 507 aa%3B fasta scores: opt: 671 z-score: 624.0 E(): 3e-29%3B33.2%25 identity in 365 aa overlap%2C to SCE34.24%2C 472 aa%3B fasta scores: opt: 666 z-score: 619.9 E(): 5.2e-29%3B 38.0%25 identity in 324 aa overlap and to SCE34.27 (partial)%2C >356 aa%3B fasta scores: opt: 554 z-score: 518.2 E(): 2.4e-23%3B 35.7%25 identity in 361 aa overlap. Contains a possible hydrophobic membrane spanning region at N-terminal domain gene gene3060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3042 SCO3043 SCO3043 SCE34.24 SCE34.24 3331178 3332596 + hypothetical protein SCE34.24%2C conserved hypothetical protein%2C len: 472 aa%3B similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA%2C 770 aa%3B fasta scores: opt: 1249 z-score: 1391.4 E(): 0%3B 52.0%25 identity in 429 aa overlap%2C to Streptomyces coelicolor SCE34.26%2C 507 aa%3B fasta scores: opt: 2161 z-score: 2203.4 E(): 0%3B 70.9%25 identity in 471 aa overlap%2C to SCE34.23%2C 404 aa%3B fasta scores: opt: 666 z-score: 682.6 E(): 1.6e-32%3B 38.0%25 identity in 324 aa overlap%2C to SCE34.27 (fragment)%2C >356 aa%3B fasta scores: opt: 659 z-score: 676.4 E(): 3.7e-32%3B 39.9%25 identity in 348 aa overlap and to SCE35.25%2C 507 aa%3B fasta scores: opt: 644 z-score: 658.7 E(): 3.5e-31%3B 34.0%25 identity in 509 aa overlap gene gene3061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3043 SCO3044 SCO3044 SCE34.25 SCE34.25 3332956 3334479 + hypothetical protein SCE34.25%2C conserved hypothetical protein%2C len: 507 aa%3B similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA%2C 770 aa%3B fasta scores: opt: 711 z-score: 770.7 E(): 0%3B 33.9%25 identity in 508 aa overlap%2C to Streptomyces coelicolor SCE34.27 (fagment)%2C >356 aa%3B fasta scores: opt: 1210 z-score: 1128.7 E(): 0%3B 51.5%25 identity in 359 aa overlap%2C to SCE34.26%2C 507 aa%3B fasta scores: opt: 739 z-score: 689.6 E(): 6.7e-33%3B 33.1%25 identity in 508 aa overlap%2C to SCE34.23%2C 404 aa%3B fasta scores: opt: 671 z-score: 628.0 E(): 1.8e-29%3B 33.2%25 identity in 365 aa overlap and to SCE34.24%2C 472 aa%3B fasta scores: opt: 644 z-score: 601.9 E(): 5.1e-28%3B 34.6%25 identity in 509 aa overlap. Contains possible hydrophobic membrane spanning region gene gene3062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3044 SCO3045 SCO3045 SCE34.26 SCE34.26 3334869 3336392 + hypothetical protein SCE34.26%2C hypothetical protein%2C len: 507 aa%3B similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA%2C 770 aa%3B fasta scores: opt: 1350 z-score: 1461.9 E(): 0%3B 55.1%25 identity in 430 aa overlap%2C to Streptomyces coelicolor SCE34.24%2C 472 aa%3B fasta scores: opt: 2161 z-score: 2145.7 E(): 0%3B 70.9%25 identity in 471 aa overlap%2C to SCE34.25%2C 507 aa%3B fasta scores: opt: 739 z-score: 735.6 E(): 0%3B 31.9%25 identity in 508 aa overlap%2C to SCE34.23%2C 404 aa%3B fasta scores: opt: 709 z-score: 707.2 E(): 7e-34%3B 36.4%25 identity in 357 aa overlap and to SCE34.27 (fragment)%2C >356 aa%3B fasta scores: opt: 643 z-score: 642.5 E(): 2.8e-30%3B 39.5%25 identity in 354 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3045 SCO3046 SCO3046 SCBAC19G2.01 SCBAC19G2.01 3336677 3338146 + hypothetical protein SCBAC19G2.01%2C conserved hypothetical protein%2C len: >199aa: similar to neighbouring gene TR:Q9KZK1 (EMBL:AL353862) conserved hypothetical protein SCE34.25 fasta scores%3B opt: 558%2C Z-score: 599.1%2C 44.796%25 identity (50.254%25 ungapped) in 221 aa overlap. Contains possible hydrophobic membrane spanning regions~SCE34.27%2C conserved hypothetical protein (fragment)%2C len: >357 aa%3B similar to TR:O68907 (EMBL:AF05830) Streptomyces roseofulvus FrnA%2C 770 aa%3B fasta scores: opt: 676 z-score: 755.5 E(): 0%3B 43.3%25 identity in 293 aa overlap%2C to Streptomyces coelicolor SCE34.25%2C 507 aa%3B fasta scores: opt: 1210 z-score: 1247.7 E(): 0%3B 51.5%25 identity in 359 aa overlap%2C to SCE34.24%2C 472 aa%3B fasta scores: opt: 659 z-score: 681.3 E(): 1.9e-32%3B 39.9%25 identity in 348 aa overlap%2C to SCE34.26%2C 507 aa%3B fasta scores: opt: 643 z-score: 664.4 E(): 1.7e-31%3B 39.5%25 identity in 354 aa overlap and to SCE34.23%2C 404 aa%3B fasta scores: opt: 554 z-score: 574.2 E(): 1.8e-26%3B 35.3%25 identity in 357 aa overlap gene gene3064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3046 SCO3047 SCO3047 SCBAC19G2.02 SCBAC19G2.02 3338276 3339850 + hypothetical protein SCBAC19G2.02%2C possible membrane protein%2C len: 524aa: similar to many eg. neighbouring gene TR:Q9KZK3 (EMBL:AL353862) SCE34.23 transcriptional regulator (396 aa) fasta scores%3B opt: 631%2C Z-score: 610.7%2C 36.011%25 identity (38.235%25 ungapped) in 361 aa overlap and TR:O68907 (EMBL:AF058302) FrnA from polyketide antibiotic frenolicin biosynthetic cluster of Streptomyces roseofulvus (770 aa) fasta scores%3B opt: 482%2C Z-score: 464.5%2C 28.387%25 identity (32.195%25 ungapped) in 465 aa overlap. Contains possible membrane-spanning hydrophobic region. Also has region of similarity with adjacent CDS SCBAC19F3.03c. gene gene3065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3047 SCO3048 SCO3048 SCBAC19G2.03c SCBAC19G2.03c 3339882 3341075 - hypothetical protein SCBAC19G2.03c%2C possible membrane protein%2C len: 397aa: similar to TR:O69850 (EMBL:AL023702) transcriptional regulator from Streptomyces coelicolor (366 aa) fasta scores%3B opt: 615%2C Z-score: 578.6%2C 34.694%25 identity (37.072%25 ungapped) in 343 aa overlap. Contains possible membrane-spanning hydrophobic region. Also has region of similarity with adjacent CDS SCBAC19F3.02. gene gene3066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3048 SCO3049 SCO3049 SCBAC19G2.04 SCBAC19G2.04 3341259 3341852 + acyl-CoA thioesterase SCBAC19G2.04%2C possible acyl-CoA hydrolase%2C len: 197 aa: similar to many e.g. SW:Q64559 (CTE2_RAT) rat brain cytosolic acyl-coenzyme A thioester hydrolase (338 aa) fasta scores%3B opt: 353%2C Z-score: 394.1%2C 34.973%25 identity (35.754%25 ungapped) in 183 aa overlap and TR:Q9I0E9 (EMBL:AE004697) hypothetical protein from Pseudomonas aeruginosa (166 aa) fasta scores%3B opt: 391%2C Z-score: 440.1%2C 42.949%25 identity (44.667%25 ungapped) in 156 aa overlap. Contains Pfam match to entry PF01662 Acyl-CoA_hydro%2C Cytosolic long-chain acyl-CoA thioester hydrolase. gene gene3067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3049 SCO3050 SCO3050 SCBAC19G2.05c SCBAC19G2.05c 3341888 3342928 - hypothetical protein SCBAC19G2.05c%2C unknown%2C len: 346aa: no significant database matches. gene gene3068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3050 SCO3051 SCO3051 fadE fadE 3343070 3344227 - acyl-CoA dehydrogenase SCBAC19G2.06c%2C fadE%2C acyl-CoA dehydrogenase%2C len: 385 aa: similar to many e.g. TR:Q9RIQ5 (EMBL:AJ250495) fatty acid acyl CoA dehydrogenase FadE from Streptomyces lividans (385 aa) fasta scores%3B opt: 2480%2C Z-score: 2753.5%2C 99.740%25 identity (99.740%25 ungapped) in 385 aa overlap and SW:P45867 (ACDA_BACSU) acyl CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores%3B opt: 1214%2C Z-score: 1351.1%2C 53.600%25 identity (54.472%25 ungapped) in 375 aa overlap. Also similar to TR:Q9RKY7 (EMBL:AL133213) SC6D7.11 Acd acyl CoA dehydrogenase from Streptomyces coelicolor (391 aa) fasta scores%3B opt: 1079%2C Z-score: 1201.3%2C 47.244%25 identity (48.387%25 ungapped) in 381 aa overlap. Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase%2C C-terminal domain%3B Pfam match to entry PF02770 Acyl-CoA_dh_M%2C Acyl-CoA dehydrogenase%2C middle domain%3B Pfam match to entry PF02771 Acyl-CoA_dh_N%2C Acyl-CoA dehydrogenase%2C N-terminal domain%3B Prosite match to PS00072 Acyl-CoA dehydrogenases signature 1 and Prosite match to PS00073 Acyl-CoA dehydrogenases signature 2. gene gene3069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3051 SCO3052 SCO3052 SCBAC19G2.07 SCBAC19G2.07 3344420 3345763 + UDP-glucose 6-dehydrogenase SCBAC19G2.07%2C probable UDP-glucose 6-dehydrogenase%2C len: 447aa: similar to many eg. SW:O54068 (UDG_RHIME) UDP-glucose 6-dehydrogenase RkpK from Rhizobium meliloti EC:1.1.1.22 (437 aa) fasta scores%3B opt: 1101%2C Z-score: 1198.1%2C 43.080%25 identity (44.780%25 ungapped) in 448 aa overlap. Contains Pfam match to entry PF00984 UDPG_MGDP_dh%2C UDP-glucose/GDP-mannose dehydrogenase family. gene gene3070 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3052 SCO3053 SCO3053 SCBAC19G2.08c SCBAC19G2.08c 3345819 3347939 - esterase SCBAC19G2.08c%2C possible esterase%2C len: 706 aa: similar to many from streptomycetes e.g. TR:Q54345 (EMBL:Z50108) FusH fusidic acid inactivating esterase from Streptomyces lividans 66 (509 aa) fasta scores%3B opt: 821%2C Z-score: 876.2%2C 36.782%25 identity (40.592%25 ungapped) in 522 aa overlap and TR:Q9ADF5 (EMBL:AL589708) esterase FusH from Streptomyces coelicolor (520 aa) fasta scores: opt: 816 Z-score: 872.0 E(): 6.4e-41%3B 36.154%25 identity in 520 aa overlap. Contains a possible non-cleavable N-terminal signal sequence%3B Pfam match to entry PF01453 Agglutinin%2C Lectin (probable mannose binding)%3B Pfam match to entry PF00089 trypsin%2C Trypsin and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. C-terminal region contains a degenerate repeat sequence. Contains possible N-terminal region signal peptide sequence gene gene3071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3053 SCO3054 SCO3054 SCBAC19G2.09c SCBAC19G2.09c 3348346 3348852 - hypothetical protein SCBAC19G2.09c%2C conserved hypothetical protein%2C len: 168aa: similar to many in Streptomyces coelicolor eg. TR:Q9F2X0 (EMBL:AL392148) SCD20.09 hypothetical protein (190 aa) fasta scores%3B opt: 250%2C Z-score: 285.6%2C 34.503%25 identity (38.816%25 ungapped) in 171 aa overlap. gene gene3072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3054 SCO3055 SCO3055 SCBAC19G2.10 SCBAC19G2.10 3348964 3349323 + hypothetical protein SCBAC19G2.10%2C conserved hypothetical protein%2C len: 119aa: similar to many in Streptomyces coelicolor e.g. TR:O85701 (EMBL:AF072709) 3SCF60.11c conserved hypothetical protein (131 aa) fasta scores%3B opt: 322%2C Z-score: 387.9%2C 42.017%25 identity in 119 aa overlap and downstream neighbouring CDS SCBAC19G2.11 gene gene3073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3055 SCO3056 SCO3056 SCBAC19G2.11 SCBAC19G2.11 3349353 3349745 + hypothetical protein SCBAC19G2.11%2C conserved hypothetical protein%2C len: aa: similar to many in Streptomyces coelicolor eg. TR:Q9F3E9 (EMBL:AL450289) SC2H2.06 hypothetical protein (150 aa) fasta scores%3B opt: 340%2C Z-score: 415.4%2C 46.032%25 identity in 126 aa overlap and upstream neighbouring CDS SCBAC19G2.10 gene gene3074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3056 SCO3057 SCO3057 SCBAC19G2.12c SCBAC19G2.12c 3349758 3350888 - dipeptidase SCBAC19G2.12c%2C possible dipeptidase%2C len: 376 aa: similar to many eukaryotic peptidases e.g. SW:P31430 (MDP1_RAT) rat renal dipeptidase (410 aa) fasta scores%3B opt: 440%2C Z-score: 474.0%2C 36.056%25 identity (38.906%25 ungapped) in 355 aa overlap. Also weakly similar to TR:Q9KH70 (EMBL:AF268476) thermostable dipeptidase from Brevibacillus borstelensis (307 aa) fasta scores%3B opt: 273%2C Z-score: 298.4%2C 28.159%25 identity (30.116%25 ungapped) in 277 aa overlap. Contains Pfam match to entry PF01244 Renal_dipeptase%2C Renal dipeptidase. Also similar to neighbouring upstream CDS SCBAC19G2.13c gene gene3075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3057 SCO3058 SCO3058 SCBAC19G2.13c SCBAC19G2.13c 3351008 3352210 - dipeptidase SCBAC19G2.13c%2C possible dipeptidase%2C len: 400 aa: similar to many eukaryotic peptidases e.g. SW:P31429 (MDP1_RABIT) rabbit renal dipeptidase (410 aa) fasta scores%3B opt: 788%2C Z-score: 879.1%2C 42.432%25 identity (48.580%25 ungapped) in 403 aa overlap. Also weakly similar to TR:Q9KH70 (EMBL:AF268476) thermostable dipeptidase from Brevibacillus borstelensis (307 aa) fasta scores%3B opt: 450%2C Z-score: 506.1%2C 31.034%25 identity (36.486%25 ungapped) in 348 aa overlap. Contains Pfam match to entry PF01244 Renal_dipeptase%2C Renal dipeptidase. Also similar to neighbouring downstream CDS SCBAC19G2.12c gene gene3076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3058 SCO3059 SCO3059 purE purE 3352225 3352767 - 5-(carboxyamino)imidazole ribonucleotide mutase SCBAC19G2.14c%2C phosphoribosylaminoimidazole carboxylase catalytic subunit PurE%2C len: 180aa: strongly similar to many eg. SW:Q44679 (PUR6_CORAM) phosphoribosylaminoimidazole carboxylase catalytic subunit PurE from Corynebacterium ammoniagenes (177 aa) fasta scores%3B opt: 666%2C Z-score: 735.8%2C 65.541%25 identity (65.541%25 ungapped) in 148 aa overlap and TR:O80937 (EMBL:AC004684) phosphoribosylaminoimidazole carboxylase from Arabidopsis thaliana (645 aa) fasta scores%3B opt: 644%2C Z-score: 703.2%2C 60.870%25 identity (60.870%25 ungapped) in 161 aa overlap. Contains Pfam match to entry PF00731 AIRC%2C AIR carboxylase. gene gene3077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3059 SCO3060 SCO3060 purK purK 3352764 3353999 - 5-(carboxyamino)imidazole ribonucleotide synthase With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway gene gene3078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3060 SCO3061 SCO3061 SCE25.02 SCE25.02 3354084 3354656 + hypothetical protein SCE25.02%2C possible integral membrane protein%2C len: 190 aa%3B similar to TR:P96882 (EMBL:Z92771) Mycobacterium tuberculosis hypothetical 30.1 kD protein MTCY71.17%2C 272 aa%3B fasta scores: opt: 197 z-score: 245.6 E(): 3.2e-06%3B 32.0%25 identity in 150 aa overlap. Contains possible hydrophobis membrane spanning regions gene gene3079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3061 SCO3062 SCO3062 SCE25.03c SCE25.03c 3354681 3355955 - two-component system histidine kinase SCE25.03c%2C probable two-component system histidine kinase%2C len: 424 aa%3B similar to TR:O86661 (EMBL:AL031182) Streptomyces coelicolor two-component sensor SC4A2.05%2C 436 aa%3B fasta scores: opt: 486 z-score: 535.4 E(): 2.3e-22%3B 31.8%25 identity in 450 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase. Contains possible hydrophobic membrane spanning regions gene gene3080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3062 SCO3063 SCO3063 SCE25.04c SCE25.04c 3355990 3356667 - two-component system reponse regulator SCE25.04c%2C probable two-component system reponse regulator%2C len: 225 aa%3B similar to TR:CAB77324 (EMBL:AL160331) Streptomyces coelicolor response regulator SCD8A.03%2C 223 aa%3B fasta scores: opt: 688 z-score: 781.9 E(): 0%3B 48.9%25 identity in 223 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene3081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3063 SCO3064 SCO3064 SCE25.05 SCE25.05 3357162 3358658 + peptide transporter SCE25.05%2C probable peptide transporter%2C len: 498 aa%3B similar to SW:DTPT_LACLA (EMBL:U05215) Lactococcus lactis di-/tripeptide transporter DtpT%2C 463 aa%3B fasta scores: opt: 1105 z-score: 1248.4 E(): 0%3B 38.2%25 identity in 468 aa overlap. Contains Pfam match to entry PF00854 PTR2%2C POT family and match to Prosite entry PS01023 PTR2 family proton/oligopeptide symporters signature 2 and possible hydrophobic membrane spanning regions gene gene3082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3064 SCO3065 SCO3065 SCE25.06 SCE25.06 3358788 3359225 + hypothetical protein SCE25.06%2C hypothetical protein%2C len: 145 aa%3B similar to TR:CAB86125 (EMBL:AL163003) Streptomyces coelicolor hypothetical 16.0 kD protein%2C SCC24.31c%2C 142 aa%3B fasta scores: opt: 338 z-score: 419.4 E(): 6.6e-16%3B 42.6%25 identity in 141 aa overlap gene gene3083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3065 SCO3066 SCO3066 SCE25.07c SCE25.07c 3359355 3359867 - regulator of Sig15 SCE25.07c%2C regulator of Sig15%2C len: 170 aa%3B identical to previously sequenced TR:CAB55834 (EMBL:AJ249581) Streptomyces coelicolor A3(2) regulator of Sig15%2C 170 aa gene gene3084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3066 SCO3067 SCO3067 SCE25.08c SCE25.08c 3360064 3360441 - anti anti sigma factor SCE25.08c%2C anti anti sigma factor%2C len: 125 aa%3B identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) anti anti sigma factor%2C 125 aa. Contains Pfam match to entry PF01740 SpoIIAA%2C SpoIIAA family gene gene3085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3067 SCO3068 SCO3068 SCE25.09 SCE25.09 3360694 3361608 + RNA polymerase sigma factor SCE25.09%2C sig15%2C RNA polymerase sigma factor%2C len: 304 aa%3B identical to previously sequenced TR:CAB55836 (EMBL:AJ249581) Streptomyces coelicolor A3(2) RNA polymerase sigma factor Sig15%2C 304 aa. Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and match to Prosite entry PS00715 Sigma-70 factors family signature 1. Contains also possible helix-turn-helix motif at residues 269..290 (+6.83 SD) gene gene3086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3068 SCO3069 SCO3069 SCE25.10c SCE25.10c 3361685 3362029 - hypothetical protein SCE25.10c%2C possible integral membrane protein%2C len: 114 aa. Contains possible hydrophobic membrane spanning regions gene gene3087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3069 SCO3070 SCO3070 SCE25.11c SCE25.11c 3362037 3363212 - imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate%2C the third step in the histidine degradation pathway gene gene3088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3070 SCO3071 SCO3071 SCE25.12c SCE25.12c 3363269 3364618 - N-formimino-L-glutamate deiminase catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate gene gene3089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3071 SCO3072 SCO3072 SCE25.13c SCE25.13c 3364615 3365832 - allantoate amidohydrolase allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar%3B the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia%3B carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids%2C ammonia%2C and carbon dioxide gene gene3090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3072 SCO3073 SCO3073 hutU hutU 3365829 3367547 - urocanate hydratase catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism gene gene3091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3073 SCO3074 SCO3074 SCE25.15c SCE25.15c 3367747 3368334 - hypothetical protein SCE25.15c%2C possible integral membrane protein%2C len: 195 aa. Contains possible hydrophobic membrane spanning regions gene gene3092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3074 SCO3075 SCO3075 SCE25.16c SCE25.16c 3368495 3369364 - transcriptional regulator SCE25.16c%2C possible transcriptional regulator%2C len: 289 aa%3B similar to SW:HEXR_PSEAE (EMBL:AF029673) Pseudomonas aeruginosa hex regulon repressor HexR%2C 285 aa%3B fasta scores: opt: 197 z-score: 227.5 E(): 3.2e-05%3B 27.7%25 identity in 220 aa overlap. Contains possible helix-turn-helix motif at residues 50..71 (+2.54 SD) gene gene3093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3075 SCO3076 SCO3076 SCE25.17 SCE25.17 3369483 3369953 + hypothetical protein SCE25.17%2C possible integral membrane protein%2C len: 156 aa. Contains possible hydrophobic membrane spanning regions gene gene3094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3076 SCO3077 SCO3077 SCE25.18c SCE25.18c 3370359 3371744 - cystathionine beta-synthase SCE25.18%2C probable cystathionine beta-synthase%2C len: 461 aa%3B highly similar to TR:O53425 (EMBL:AL021897) Mycobacterium tuberculosis cystathionine beta-synthase CysM%2C 464 aa%3B fasta scores: opt: 2025 z-score: 2184.8 E(): 0%3B 67.6%25 identity in 454 aa overlap%2C to TR:Q9YHU3 (EMBL:AF090120) Fugu rubripe cystathionine beta-synthase%2C 585 aa%3B fasta scores: opt: 1087 z-score: 1173.5 E(): 0%3B 39.6%25 identity in 465 aa overlap and to TR:CAB50991 (EMBL:AL096852) Streptomyces coelicolor cysteine synthase SCE19A.10c%2C 316 aa%3B fasta scores: opt: 558 z-score: 540.6 E(): 1.4e-24%3B 40.3%25 identity in 303 aa overlap. Contains Pfam matches to entries PF00291 S_T_dehydratase%2C Pyridoxal-phosphate dependent enzyme%2C 2x PF00571 CBS%2C CBS domain and match to Prosite entry PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site gene gene3095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3077 SCO3078 SCO3078 SCE25.19 SCE25.19 3371912 3372934 + hypothetical protein SCE25.19%2C possible hypothetical protein%2C len: 340 aa%3B similar to TR:O53423 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 32.9 kD protein MTV017.28c%2C 314 aa%3B fasta scotes: opt: 519 z-score: 544.7 E(): 7e-23%3B 38.3%25 identity in 332 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3078 SCO3079 SCO3079 SCE25.20 SCE25.20 3373160 3374380 + acetyl-CoA acetyltransferase Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase%2C catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation gene gene3097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3079 SCO3080 SCO3080 SCE25.21 SCE25.21 3374675 3375484 + hypothetical protein SCE25.21%2C possible hypothetical protein%2C len: 269 aa. Contains possible N-terminal region signal peptide sequence gene gene3098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3080 SCO3081 SCO3081 SCE25.22c SCE25.22c 3375535 3375828 - hypothetical protein SCE25.22c%2C unknown%2C len: 97 aa gene gene3099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3081 SCO3082 SCO3082 SCE25.23 SCE25.23 3375950 3376180 + hypothetical protein SCE25.23%2C unknown%2C len: 76 aa gene gene3100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3082 SCO3083 SCO3083 SCE25.24c SCE25.24c 3376252 3377175 - hypothetical protein SCE25.24c%2C possible integral membrane protein%2C len: 307 aa%3B highly similar to TR:Q54192 (EMBL:M80628) Streptomyces griseus transfer hypothetical product%2C 293 aa%3B fasta scores: opt: 1265 z-score: 1184.1 E(): 0%3B 70.7%25 identity in 307 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3083 SCO3084 SCO3084 pobA pobA 3377344 3378513 - 4-hydroxybenzoate 3-monooxygenase catalyzes the formation of protocatechuate from 4-hydroxybenzoate gene gene3102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3084 SCO3085 SCO3085 SCE25.26c SCE25.26c 3378735 3379088 - hypothetical protein SCE25.26c%2C possible membarne protein%2C len: 117 aa. Contains possible hydrophobic membrane spanning regions gene gene3103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3085 SCO3086 SCO3086 SCE25.27 SCE25.27 3379423 3380202 + lipoprotein SCE25.27%2C possible lipoprotein%2C len: 259 aa. Contains matches to Prosite entries PS00013 Prokaryotic membrane lipoprotein lipid attachment site (correctly situated) and PS00017 ATP/GTP-binding site motif A (P-loop)%2C possible N-terminal region signal peptide sequence and high content in alanine and glycine amino acid residues gene gene3104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3086 SCO3087 SCO3087 SCE25.28c SCE25.28c 3380229 3380874 - gene gene3105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3087 SCO3088 SCO3088 SCE25.29c SCE25.29c 3381094 3381339 - hypothetical protein SCE25.29c%2C doubtful CDS%2C function unknown%2C len: 81 aa. Hig content in alanine and glycine amino acid residues gene gene3107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3088 SCO3089 SCO3089 SCE25.30 SCE25.30 3381453 3382223 + ABC transporter ATP-binding protein SCE25.30 probable ABC transporter ATP-binding protein%2C len: 256 aa%3B similar to TR:CAB81857 (EMBL:AL16169) Streptomyces coelicolor ABC transporter ATP-binding protein SCD40A.12c%2C 246 aa%3B fasta scores: opt: 922 z-score: 1039.0 E(): 0%3B 58.4%25 identity in 238 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene3108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3089 SCO3090 SCO3090 SCE25.31 SCE25.31 3382330 3384861 + ABC transporter SCE25.31%2C possible ABC transporter integral membrane protein%2C len: 843 aa%3B similar to TR:CAB77000 (EMBL:AL159178) Streptomyces coelicolor integral membrane protein SCH22A.31%2C 850 aa%3B fasta scores: opt: 675 z-score: 676.0 E(): 3.4e-30%3B 26.4%25 identity in 879 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3090 SCO3091 SCO3091 SCE25.32c SCE25.32c 3384933 3386249 - cyclopropane-fatty-acyl-phospholipid synthase SCE25.32c%2C cyclopropane-fatty-acyl-phospholipid synthase%2C len: 438 aa%3B similar to TR:AAF1173 (EMBL:AE002051) Deinococcus radiodurans cyclopropane-fatty-acyl-phospholipid synthase%2C DR2187%2C 462 aa%3B fasta scores: opt: 832 z-score: 910.3 E(): 0%3B 42.7%25 identity in 433 aa overlap and to SW:CFA_ECOLI (EMBL:M98330) Escherichia coli cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) (cyclopropane fatty acid synthase) (CFA synthase) Cfa or CdfA%2C 381 aa%3B fasta scores: opt: 482 z-score: 530.2 E(): 4.5e-22%3B 38.0%25 identity in 303 aa overlap gene gene3110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3091 SCO3092 SCO3092 SCE25.33c SCE25.33c 3386513 3387853 - oxidoreductase SCE41.01c%2C probable oxidoreductase (fragment)%2C len: >317 aa%3B similar to SW:DHNA_ECOLI (EMBL:V00306) Escherichia coli NADH dehydrogenase (EC 1.6.99.3) Ndh%2C 433 aa%3B fasta scores: opt: 361 z-score: 417.8 E(): 9.1e-16%3B 27.6%25 identity in 330 aa overlap and to TR:CAB92372 (EMBL:AL356612) Streptomyces coelicolor NADH dehydrogenase SCD72A.05%2C 442 aa%3B fasta scores: opt: 1185 z-score: 1267.3 E(): 0%3B 57.0%25 identity in 321 aa overlap. Contains Pfam match to entry PF00070 pyr_redox%2C Pyridine nucleotide-disulphide oxidoreductase~SCE25.33c%2C possible dehydrogenase (fragment)%2C len: >162 aa%3B similar to TR:Q9ZC17 (EMBL:AL033505) Streptomyces coelicolor dehydrogenase SC1E6.05%2C 629 aa%3B fasta scores: opt: 209 z-score: 253.8 E(): 1.1e-06%3B 32.6%25 identity in 141 aa overlap and to C-terminal region of SW:DHNA_ECOLI (EMBL:V00306) Escherichia coli NADH dehydrogenase (EC 1.6.99.3) Ndh%2C 433 aa%3B fasta scores: opt: 116 z-score: 145.6 E(): 1.2%3B 26.8%25 identity in 82 aa overlap gene gene3111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3092 SCO3093 SCO3093 SCE41.02c SCE41.02c 3388379 3389320 - hydrolase SCE41.02c%2C possible hydrolase%2C len: 313 aa%3B similar to N-terminal region of SW:GPPA_ECOLI (EMBL:M87049) Escherichia coli guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase (EC 3.6.1.40) GppA%2C 494 aa%3B fasta scores: opt: 311 z-score: 357.2 E(): 2.2e-12%3B 28.4%25 identity in 310 aa overlap gene gene3112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3093 SCO3094 SCO3094 SCE41.03c SCE41.03c 3389317 3389877 - hypothetical protein SCE41.03c%2C conserved hypothetical protein%2C len: 186 aa%3B similar to TR:P96375 (EMBL:Z92539) Mycobacterium tuberculosis hypothetical 16.6 kDa protein MTCY10G2.24c%2C 155 aa%3B fasta scores: opt: 632 z-score: 730.7 E(): 0%3B 67.6%25 identity in 136 aa overlap gene gene3113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3094 SCO3095 SCO3095 SCE41.04c SCE41.04c 3389963 3390487 - hypothetical protein SCE41.04c%2C membrane protein%2C len: 174 aa%3B similar to TR:P96376 (EMBL:Z92539) Mycobacterium tuberculosis hypothetical 24.6 kDa protein MTC10G2.25c%2C 228 aa%3B fasta scores: opt: 273 z-score: 332.6 E(): 5.1e-11%3B 35.6%25 identity in 149 aa overlap. Contains possible coiled-coil region at approx residues 87..106 and possible hydrophobic membrane spanning regions gene gene3114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3095 SCO3096 SCO3096 eno eno 3390541 3391821 - phosphopyruvate hydratase enolase%3B catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis gene gene3115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3096 SCO3097 SCO3097 SCE41.06c SCE41.06c 3392083 3392817 - hypothetical protein SCE41.06c%2C possible hypothetical protein%2C len: 244 aa%3B similar to TR:O86308 (EMBL:Z96935) Micrococcus luteus Rpf protein precursor%2C 220 aa%3B fasta scores: opt: 366 z-score: 357.9 E(): 2e-12%3B 39.7%25 identity in 234 aa overlap. Contains Pfam match to entry PF01476 PG_binding_2%2C peptidoglycan binding domain and possible N-terminal region signal peptide sequence gene gene3116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3097 SCO3098 SCO3098 SCE41.07c SCE41.07c 3393171 3394196 - hypothetical protein SCE41.07c%2C possible hypothetical protein%2C len: 341 aa%3B similar to TR:O53879 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 40.0 kDa protein MTV043.60c%2C 407 aa%3B fasta scores: opt: 443 z-score: 346.0 E(): 9.1e-12%3B 33.3%25 identity in 234 aa overlap. Contains Pfam match to entry PF01476 PG_binding_2%2C peptidoglycan binding domain and high content in serine and glycine amino acid residues. Also contains a possible N-terminal region signal peptide sequence gene gene3117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3098 SCO3099 SCO3099 SCE41.08c SCE41.08c 3394340 3395641 - cytochrome P450 hydroxylase SCE41.08c%2C probable cytochrome P450 hydroxylase%2C len: 433 aa%3B similar to SW:CPXR_BRAJA (EMBL:U12678) Bradyrhizobium japonicum cytochrome P450 BJ-3 (EC 1.14.14.-) CYP114%2C 429 aa%3B fasta scores: opt: 682 z-score: 792.5 E(): 0%3B 32.9%25 identity in 435 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 gene gene3118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3099 SCO3100 SCO3100 SCE41.09c SCE41.09c 3395638 3396615 - nucleoside triphosphate pyrophosphohydrolase functions in degradation of stringent response intracellular messenger ppGpp%3B in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF%3B activity of MazG is inhibited by MazEF in vitro%3B ppGpp inhibits mazEF expression%3B MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation%3B MazG also interacts with the GTPase Era gene gene3119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3100 SCO3101 SCO3101 SCE41.10c SCE41.10c 3396692 3397339 - lipoprotein SCE41.10c%2C possible lipoprotein%2C len: 215 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3101 SCO3102 SCO3102 pkaE pkaE 3397490 3398953 - protein kinase SCE41.11c%2C pkaE%2C eukaryotic-type protein kinase%2C len: 487 aa%3B identical to previously sequenced TR:Q9ZNB6 (EMBL:AB018799) Streptomyces coelicolor eukaryotic-type protein kinase PkaE%2C 287 aa. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature gene gene3121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3102 SCO3103 SCO3103 SCE41.12c SCE41.12c 3399019 3399624 - hypothetical protein SCE41.12c%2C possible integral membrane protein%2C len: 201 aa. Contains possible hydrophobic membrane spanning regions gene gene3122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3103 SCO3104 SCO3104 SCE41.13c SCE41.13c 3399763 3401802 - hypothetical protein SCE41.13c%2C unknown%2C len: 679 aa gene gene3123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3104 SCO3105 SCO3105 SCE41.14 SCE41.14 3401899 3402504 + hypothetical protein SCE41.14%2C unknown%2C len: 201 aa gene gene3124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3105 SCO3106 SCO3106 SCE41.15 SCE41.15 3402554 3403453 + lipoprotein SCE41.15%2C possible lipoprotein%2C len: 299 aa%3B similar to TR:CAB76294 (EMBL:AL158057) Streptomyces coelicolor lipoprotein SC10G8.21c%2C 249 aa%3B fasta scores: opt: 407 z-score: 384.9 E(): 6.2e-14%3B 31.1%25 identity in 241 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3106 SCO3107 SCO3107 SCE41.16c SCE41.16c 3403521 3404297 - lipoprotein SCE41.16c%2C possible lipoprotein%2C len: 258 aa%3B similar to TR:P95123 (EMBL:Z83018) Mycobacterium tuberculosis hypothetical 25.9 kDa protein MTCY349.15%2C 237 aa%3B fasta scores: opt: 498 z-score: 531.0 E(): 4.5e-22%3B 44.1%25 identity in 186 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3107 SCO3108 SCO3108 SCE41.17 SCE41.17 3404444 3404641 + hypothetical protein SCE41.17%2C conserved hypothetical protein%2C len: 65 aa%3B similar to TR:O05901 (EMBL:Z95210) Mycobacterium tuberculosis hypothetical 6.4 kDa protein MTCY21C12.03%2C 59 aa%3B fasta scores: opt: 102 z-score: 149.9 E(): 0.76%3B 29.3%25 identity in 58 aa overlap gene gene3127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3108 SCO3109 SCO3109 SCE41.18c SCE41.18c 3404759 3408313 - transcriptional-repair coupling factor SCE41.18c%2C probable transcriptional-repair coupling factor%2C len: 1184 aa%3B similar to SW:MFD_ECOLI (EMBL:AE000211) Escherichia coli transcriptional-repair coupling factor Mfd%2C 1148 aa%3B fasta scores: opt: 2043 z-score: 2247.7 E(): 0%3B 37.5%25 identity in 1181 aa overlap . Contains Pfam match to entry PF00270 DEAD%2C DEAD/DEAH box helicase and PF00271 helicase_C%2C Helicases conserved C-terminal domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3109 SCO3110 SCO3110 SCE41.19c SCE41.19c 3408950 3411514 - ABC transporter SCE41.19c%2C possible ABC transport system integral membrane protein%2C len: 854 aa%3B similar to TR:CAB96016 (EMBL:AL360055) Streptomyces coelicolor ABC transport system integral membrane protein SCG20A.11c%2C 855 aa%3B fasta scores: opt: 1429 z-score: 1454.6 E(): 0%3B 34.0%25 identity in 871 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3110 SCO3111 SCO3111 SCE41.20c SCE41.20c 3411511 3412299 - ABC transporter ATP-binding protein SCE41.20c%2C possible ABC transport system ATP-binding protein%2C len: 262 aa%3B similar to TR: CAB89461(EMBL:AL354048) Streptomyces coelicolor ABC transporter ATP-binding protein SCE25.31%2C 256 aa%3B fasta scores: opt: 1240 z-score: 1356.4 E(): 0%3B 75.2%25 identity in 246 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene3130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3111 SCO3112 SCO3112 SCE41.21c SCE41.21c 3413025 3413129 - hypothetical protein SCE41.21c%2C partial CDS%2C len: 105 bp. Transposase remnant. Similar to TR:Q9X8Z6 TRANSPOSASE. Continuous with SCE41.22 when reversed gene gene3131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3112 SCO3113 SCO3113 SCE41.22 SCE41.22 3413130 3413195 + hypothetical protein SCE41.22%2C partial CDS%2C len: 66 bp. Transposase remnant. Similar to TR:Q9X8Z6 TRANSPOSASE. Continuous with SCE41.21c when reversed gene gene3132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3113 SCO3114 SCO3114 SCE41.23c SCE41.23c 3413804 3414700 - hypothetical protein SCE41.23c%2C conserved hypothetical protein%2C len: 298 aa%3B similar to TR:O07481 (EMBL:Z97071) Streptomyces reticuli AbpS protein%2C 311 aa%3B fasta scores: opt: 482 z-score: 473.6 E(): 7.1e-19%3B 35.0%25 identity in 294 aa overlap. Contains various coiled-coil regions at approx. residues 42..60 and 207..251 gene gene3133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3114 SCO3115 SCO3115 SCE41.24c SCE41.24c 3414901 3417570 - hypothetical protein SCE41.24c%2C unknown%2C len: 889 aa. High content in alanine%2C glycine and proline amino acid residues. Contains 20x degenerate repeat: (G/P/A/N)P(G/P/A) gene gene3134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3115 SCO3116 SCO3116 SCE41.25c SCE41.25c 3417578 3418585 - hypothetical protein SCE41.25c%2C unknown%2C len: 335 aa gene gene3135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3116 SCO3117 SCO3117 SCE41.26 SCE41.26 3418879 3419409 + hypothetical protein SCE41.26%2C unknown%2C len: 176 aa gene gene3136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3117 SCO3118 SCO3118 SCE41.27 SCE41.27 3419502 3419999 + hypothetical protein SCE41.27%2C unknown%2C len: 165 aa gene gene3137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3118 SCO3119 SCO3119 SCE41.28c SCE41.28c 3420021 3421340 - hypothetical protein SCE41.28c%2C possible sensor kinase%2C len: 439 aa%3B similar to TR:O86631 (EMBL:AL031155) Streptomyces coelicolor two-component sensor SC3A7.30%2C 429 aa%3B fasta scores: opt: 296 z-score: 316.7 E(): 3.9e-10%3B 32.9%25 identity in 395 aa overlap. Contains possible hydrophobic membrane spanning regions at N-terminal domain gene gene3138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3119 SCO3120 SCO3120 SCE41.29c SCE41.29c 3421849 3422058 - hypothetical protein SCE41.29c%2C unknown%2C len: 69 aa gene gene3139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3120 SCO3121 SCO3121 SCE41.30 SCE41.30 3422071 3422199 + hypothetical protein SCE41.30%2C unknown%2C len: 42 aa. Doubtful CDS%2C TBparse predicted gene gene3140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3121 SCO3122 SCO3122 glmU glmU 3422409 3423857 + bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase forms a homotrimer%3B catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc%3B function in cell wall synthesis gene gene3142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3122 SCO3123 SCO3123 prsA2 prsA2 3423989 3424963 + ribose-phosphate pyrophosphokinase catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP gene gene3143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3123 SCO3124 SCO3124 SCE66.03 SCE66.03 3425176 3425772 + 50S ribosomal protein L25/general stress protein Ctc the Ctc family of proteins consists of two types%2C one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response gene gene3144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3124 SCO3125 SCO3125 pth pth 3425878 3426480 + peptidyl-tRNA hydrolase Enables the recycling of peptidyl-tRNAs produced at termination of translation gene gene3145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3125 SCO3126 SCO3126 SCE66.05 SCE66.05 3426533 3427051 + hypothetical protein SCE66.05%2C possible membrane protein%2C len: 172aa%3B contains possible membrane-spanning hydrophobic regions. gene gene3146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3126 SCO3127 SCO3127 ppc ppc 3427132 3429867 - phosphoenolpyruvate carboxylase SCE66.06c%2C ppc%2C phosphoenolpyruvate carboxylase (EC 4.1.1.31)%2C len: 911 aa%3B previously sequenced as TR:Q9RNU9 (EMBL:AF177946). Strongly similar to many others eg. SW:O32483 (CAPP_RHOPA) from Rhodopseudomonas palustris (936 aa) fasta scores%3B opt: 1801%2C z-score: 1974.8%2C E(): 0%2C 38.4%25 identity in 948 aa overlap. Contains Pfam match to entry PF00311 PEPcase%2C Phosphoenolpyruvate carboxylase and Prosite match to PS00781 Phosphoenolpyruvate carboxylase active site 1. gene gene3147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3127 SCO3128 SCO3128 SCE66.07 SCE66.07 3430174 3431184 + fatty acid desaturase (membrane) SCE66.07%2C possible fatty acid desaturase (membrane)%2C len: 336 aa%3B similar to many (mainly eukaryotic) e.g. SW:O00767 (ACOD_HUMAN) acyl-CoA desaturase (EC 1.14.99.5) from Homo sapiens (Human) (359 aa) fasta scores%3B opt: 409%2C z-score: 480.0%2C E(): 2.9e-19%2C 29.7%25 identity in 330 aa overlap. Contains Pfam match to entry PF01069 Desaturase%2C Fatty acid desaturase and possible membrane-spanning hydrophobic regions. gene gene3148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3128 SCO3129 SCO3129 SCE66.08 SCE66.08 3431181 3431858 + TetR family transcriptional regulator SCE66.08%2C possible TetR-family transcriptional regulator%2C len: 225 aa%3B similar to many proposed transcriptional regulators e.g. TR:Q9RYK4 (EMBL:AE001863) transcriptional regulator%2C TetR-family from Deinococcus radiodurans (239 aa) fasta scores%3B opt: 318%2C z-score: 386.8%2C E(): 4.6e-14%2C 32.7%25 identity in 208 aa overlap. Also similar to TR:P96381 (EMBL:Z92539) hypothetical protein from Mycobacterium tuberculosis (197 aa) fasta scores%3B opt: 827%2C z-score: 991.9%2C E(): 0%2C 64.4%25 identity in 194 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif (Score 1473 (+4.20 SD) in SCE66.08 at residues 51-72 gene gene3149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3129 SCO3130 SCO3130 SCE66.09 SCE66.09 3431891 3433066 + dehydratase SCE66.09%2C possible dehydratase%2C len: 391 aa%3B similar to many e.g. SW:P31572 (CAIB_ECOLI) L-carnitine dehydratase from Escherichia coli (405 aa) fasta scores%3B opt: 440%2C z-score: 478.4%2C E(): 3.6e-19%2C 28.7%25 identity in 401 aa overlap. gene gene3150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3130 SCO3131 SCO3131 SCE66.10c SCE66.10c 3433079 3433456 - hypothetical protein SCE66.10c%2C unknown%2C len: 125aa%3B similar to TR:Q9RY42 (EMBL:AE001873) hypothetical protein from Deinococcus radiodurans gene gene3151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3131 SCO3132 SCO3132 SCE66.11c SCE66.11c 3433453 3434364 - trans-aconitate 2-methyltransferase catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate gene gene3152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3132 SCO3133 SCO3133 SCE66.12 SCE66.12 3434529 3435026 + MarR family regulatory protein SCE66.12%2C probable MarR-family regulator%2C len: 165 aa%3B similar to many e.g. SW:P42195 (PECS_ERWCH) regulatory protein PecS from Erwinia chrysanthemi (166 aa) fasta scores%3B opt: 412%2C z-score: 499.8%2C E(): 2.3e-20%2C 42.7%25 identity in 150 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family. gene gene3153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3133 SCO3134 SCO3134 SCE66.13c SCE66.13c 3434985 3435941 - two-component system response regulator SCE66.13c%2C possible two-component system response regulator%2C len: 318 aa%3B similar to many proposed regulators e.g. TR:Q9RI42 (EMBL:AL109989) LuxR family transcriptional regulator (233 aa) fasta scores%3B opt: 299%2C z-score: 339.4%2C E(): 2e-11%2C 31.6%25 identity in 234 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and helix-turn-helix motif (Score 1492 (+4.27 SD) in SCE66.13c at residue 253-274). gene gene3154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3134 SCO3135 SCO3135 SCE66.14 SCE66.14 3436004 3436459 + acetyltransferase SCE66.14%2C probable acetyltransferase%2C len: 151 aa%3B similar to many especially SW:P19997 (BLS_STRSJ) blasticidin S-acetyltransferase (confers resistance to blasticidin S antibiotic) from Streptoverticillium sp. (strain JCM4673) (136 aa) fasta scores%3B opt: 465%2C z-score: 599.3%2C E(): 6.6e-26%2C 57.3%25 identity in 131 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene3155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3135 SCO3136 SCO3136 galK galK 3436463 3437626 - galactokinase SCE66.15c%2C galK%2C galactokinase (EC 2.7.1.6)%2C len: 387aa%3B strongly similar to many eg. SW:P13227 (GAL1_STRLI) galactokinase from Streptomyces lividans (397 aa) fasta scores%3B opt: 2131%2C z-score: 2454.6%2C E(): 0%2C 88.8%25 identity in 383 aa overlap. Contains Pfam match to entry PF00288 GHMP_kinases%2C GHMP kinases ATP-binding proteins%2C Prosite match to PS00627 GHMP kinases ATP-binding domain and Prosite match to PS00106 Galactokinase signature. gene gene3156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3136 SCO3137 SCO3137 galE1 galE1 3437662 3438627 - UDP-glucose 4-epimerase SCE66.16c%2C galE1%2C UDP-glucose 4-epimerase (EC 5.1.3.2)%2C len: 321aa%3B strongly similar to many eg. SW:P13226 (GALE_STRLI) UDP-glucose 4-epimerase from Streptomyces lividans (329 aa) fasta scores%3B opt: 1791%2C z-score: 2020.5%2C E(): 0%2C 89.4%25 identity in 321 aa overlap. Contains Pfam match to entry PF01370 Epimerase%2C NAD dependent epimerase/dehydratase family. gene gene3157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3137 SCO3138 SCO3138 galT galT 3438624 3439685 - galactose-1-phosphate uridylyltransferase SCE66.17c%2C galT%2C galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)%2C len: 353aa%3B similar to many especially SW:P13212 (GAL7_STRLI) galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa) fasta scores%3B opt: 1998%2C z-score: 2363.0%2C E(): 0%2C 87.2%25 identity in 352 aa overlap. Contains Pfam match to entry PF01087 GalP_UDP_transf%2C Galactose-1-phosphate uridyl transferase and Prosite match to PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. gene gene3158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3138 SCO3139 SCO3139 SCE66.18 SCE66.18 3439885 3441573 + sodium:solute symporter SCE66.18%2C possible sodium:solute symporter%2C len: 562aa%3B similar to many eg. SW:P96169 (SGLT_VIBPA) sodium/glucose co-transporter from Vibrio parahaemolyticus (543 aa) fasta scores%3B opt: 538%2C z-score: 594.1%2C E(): 1.3e-25%2C 27.8%25 identity in 479 aa overlap. Contains Pfam match to entry PF00474 SSF%2C Sodium:solute symporter family and possible membrane-spanning hydrophobic regions. gene gene3159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3139 SCO3140 SCO3140 SCE66.19 SCE66.19 3441595 3441891 + hypothetical protein SCE66.19%2C possible membrane protein%2C len: 98aa%3B contains possible membrane-spanning hydrophobic regions. gene gene3160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3140 SCO3141 SCO3141 SCE66.20 SCE66.20 3441921 3442073 + hypothetical protein SCE66.20%2C unknown%2C partial CDS%2C len: 50 aa%3B similar region of SC5F7.16 TR:Q9S2Q1 (EMBL:AL096872) hypothetical protein from Streptomyces coelicolor (140 aa) fasta scores%3B opt: 221%2C z-score: 268.2%2C E(): 1.9e-07%2C 69.6%25 identity in 46 aa overlap. gene gene3161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3141 SCO3142 SCO3142 SCE66.21 SCE66.21 3442013 3442183 + hypothetical protein SCE66.21%2C unknown%2C partial CDS%2C len: 57 aa%3B similar region of SC5F7.16 TR:Q9S2Q1 (EMBL:AL096872) hypothetical protein from Streptomyces coelicolor (140 aa) fasta scores%3B opt: 207%2C z-score: 278.8%2C E(): 4.8e-08%2C 69.4%25 identity in 49 aa overlap. gene gene3162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3142 SCO3143 SCO3143 SCE66.22 SCE66.22 3442183 3442347 + hypothetical protein SCE66.22%2C unknown%2C partial CDS%2C len: 55 aa%3B similar region of SC5F7.15 TR:Q9S2Q0 (EMBL:AL096872) hypothetical protein from Streptomyces coelicolor (234 aa) fasta scores%3B opt: 237%2C z-score: 237.2%2C E(): 9.9e-06%2C 59.0%25 identity in 61 aa overlap. gene gene3163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3143 SCO3144 SCO3144 SCE66.23 SCE66.23 3442302 3442976 - two-component system response regulator SCE66.23%2C possible two-component system response regulator%2C len: 224aa%3B similar to many proposed regulators eg. TR:O53856 (EMBL:AL022004) response regulator from Mycobacterium tuberculosis (216 aa) fasta scores%3B opt: 352%2C z-score: 397.3%2C E(): 1.2e-14%2C 36.9%25 identity in 217 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family gene gene3164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3144 SCO3145 SCO3145 SCE66.24c SCE66.24c 3443196 3444689 - hypothetical protein SCE66.24c%2C possible hypothetical protein%2C len: 497 aa%3B similar to TR:Q9K3R8 (EMBL:AL359989) Streptomyces coelicolor membrane protein SCE66.25c%2C 490 aa%3B fasta scores: opt: 430 Z-score: 424.1 E(): 5.4e-16%3B 33.012%25 identity in 518 aa overlap. Contains possible N-terminal signal sequence gene gene3165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3145 SCO3146 SCO3146 SCE66.25c SCE66.25c 3445110 3446582 - hypothetical protein SCE66.25c%2C possible hypothetical protein%2C len: 490 aa%3B similar to TR:Q9K3R9 (EMBL:AL359989) Streptomyces coelicolor membrane protein SCE66.24c%2C 497 aa%3B fasta scores: opt: 430 Z-score: 454.0 E(): 1.2e-17%3B 33.140%25 identity) in 516 aa overlap. Contains possible N-terminal signal sequence gene gene3166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3146 SCO3147 SCO3147 SCE66.26c SCE66.26c 3447175 3448989 - ABC transporter ATP-binding protein SCE66.26c%2C possible ABC transporter ATP-binding subunit%2C len: 604aa%3B similar to many others eg. TR:O06476 (EMBL:D86418) from Bacillus subtilis (629 aa) fasta scores%3B opt: 1223%2C z-score: 1292.7%2C E(): 0%2C 37.0%25 identity in 638 aa overlap. Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter%2C three Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and two Prosite matches to PS00211 ABC transporters family signature. Also contains possible coiled-coil region 544-604aa. gene gene3167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3147 SCO3148 SCO3148 SCE66.27c SCE66.27c 3449047 3449946 - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis gene gene3168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3148 SCO3149 SCO3149 ksgA ksgA 3449961 3450821 - dimethyladenosine transferase catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA%3B mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin gene gene3169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3149 SCO3150 SCO3150 SCE66.29c SCE66.29c 3450852 3452228 - hypothetical protein SCE87.01c%2C unknown%2C partial CDS%2C len: > 329 aa. Similar in parts to Mycobacterium tuberculosis TR:O05594 (EMBL:Z94752) hypothetical 38.1 KD protein (362 aa)%2C fasta scores opt: 365 z-score: 372.3 E(): 2.3e-13 34.1%25 identity in 232 aa overlap and Bacillus subtilis SW:YABE_BACSU (EMBL:D26185) hypothetical 47.7 KD protein (437 aa)%2C fasta scores opt: 315 z-score: 321.5 E(): 1.5e-10 29.2%25 identity in 233 aa overlap.~SCE66.29c%2C unknown%2C partial CDS%2C len: >165aa%3B similar to TR:O05594 (EMBL:Z94752) hypothetical protein from Mycobacterium tuberculosis (362 aa) fasta scores%3B opt: 316%2C z-score: 379.7%2C E(): 1.1e-13%2C 37.8%25 identity in 156 aa overlap. gene gene3170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3150 SCO3151 SCO3151 SCE87.02c SCE87.02c 3452316 3453206 - hypothetical protein SCE87.02c%2C unknown%2C len: 296 aa. Highly similar to many hypothetical proteins including: Mycobacterium tuberculosis TR:O08343 (EMBL: Z94752) hypothetical protein YcfH (264 aa)%2C fasta scores opt: 576 z-score: 667.6 E(): 8.2e-30 42.7%25 identity in 279 aa overlap and Escherichia coli SW:YCFH_ECOLI (EMBL:AE000210) hypothetical 29.8 KD protein (265 aa)%2C fasta scores opt: 477 z-score: 554.2 E(): 1.7e-23 37.0%25 identity in 276 aa overlap. Contains a Pfam match to entry PF01026 UPF0006%2C Uncharacterized protein family gene gene3171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3151 SCO3152 SCO3152 SCE87.03c SCE87.03c 3453247 3453684 - hypothetical protein SCE87.03c%2C unknown%2C len: 145 aa. gene gene3172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3152 SCO3153 SCO3153 SCE87.04c SCE87.04c 3453841 3454701 - hypothetical protein SCE87.04c%2C conserved hypothetical protein%2C len: 286 aa. Highly similar to many including: Mycobacterium tuberculosis SW:YA03_MYCTU (EMBL:Z94752) hypothetical 29.7 KD protein RV1003 (285 aa)%2C fasta scores opt: 877 z-score: 992.7 E():0 53.6%25 identity in 278 aa overlap and Bacillus subtilis SW:YABC_BACSU (EMBL:D26185) hypothetical 33.0 KD protein (292 aa)%2C fasta scores opt: 640 z-score: 726.6 E():0 41.3%25 identity in 276 aa overlap. Contains a Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases. gene gene3173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3153 SCO3154 SCO3154 SCE87.05 SCE87.05 3454768 3456543 + hypothetical protein SCE87.05%2C possible integral membrane protein%2C len: 591 aa. Similar to several of undefined function e.g. Mycobacterium tuberculosis TR: O05586 (EMBL: Z94752) hypothetical 55.5 KD protein (503 aa)%2C fasta scores opt: 666 z-score: 775.7 E(): 0 39.0%25 identity in 544 aa overlap and Aeropyrum pernix TR:BAA79111 (EMBL:AP000058) 418aa long hypothetical protein (418 aa)%2C fasta scores opt: 201 z-score: 235.2 E(): 9.9e-06 30.4%25 identity in 299 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene3174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3154 SCO3155 SCO3155 SCE87.06 SCE87.06 3456597 3457136 + hypothetical protein SCE87.06%2C unknown%2C len: 179 aa. gene gene3175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3155 SCO3156 SCO3156 SCE87.07 SCE87.07 3457367 3458992 + penicillin-binding protein SCE87.07%2C possible penicillin-binding protein ( hypothetical protein)%2C len: 541 aa. Similar to many including: Bacillus subtilis SW:PBPB_BACSU (EMBL:L09703) penicillin-binding protein 2B (PBP-2B) (716 aa)%2C fasta scores opt: 221 z-score: 233.6 E(): 1.2e-05 26.8%25 identity in 336 aa overlap and Streptomyces coelicolor TR: CAB45623 (EMBL:AL079356) penicillin-binding protein SC6G9.32 (485 aa)%2C fasta scores opt: 241 z-score: 257.0 E(): 6.1e-07 28.9%25 identity in 464 aa overlap. Also similar to the neighbouring CDS SCE87.08 (591 aa)%2C fasta scores opt: 653 z-score: 627.3 E(): 1.3e-29 45.1%25 identity in 550 aa overlap. Contains a Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and a possible N-terminal signal sequence. gene gene3176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3156 SCO3157 SCO3157 SCE87.08 SCE87.08 3459077 3460852 + penicillin-binding protein SCE87.08%2C possible penicillin-binding protein ( hypothetical protein)%2C len: 591 aa. Similar to many including: Streptomyces clavuligerus TR:P72405 (EMBL:U56256) penicillin-binding protein PcbR (551 aa)%2C fasta scores opt: 775 z-score: 731.0 E(): 0 36.5%25 identity in 526 aa overlap and Streptomyces coelicolor TR:CAB45214 (EMBL:AL079308) penicillin-binding protein SCH69.17 (490 aa)%2C fasta scores opt: 234 z-score: 226.4 E(): 3.1e-05 26.2%25 identity in 416 aa overlap. Also similar to the neighbouring CDS SCE87.07 (541 aa)%2C fasta scores opt: 653 z-score: 513.9 E(): 2.7e-23 45.1%25 identity in 550 aa overlap. Contains a Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and a possible N-terminal signal sequence. gene gene3177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3157 SCO3158 SCO3158 SCE87.09c SCE87.09c 3460797 3461177 - hypothetical protein SCE87.09c%2C unknown%2C len: 126 aa. Similar to two regulators from Streptomyces coelicolor: TR:CAB51005 (EMBL:AL096852) SCE19A.24 (142 aa)%2C fasta scores opt: 168 z-score: 227.4 E(): 2.7e-05 32.7%25 identity in 101 aa overlap and TR:CAB40672 (EMBL: AL049587) SC5F2A.05C (138 aa)%2C fasta scores opt: 222 z-score: 296.3 E(): 3.9e-09 36.0%25 identity in 114 aa overlap. gene gene3178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3158 SCO3159 SCO3159 SCE87.10 SCE87.10 3461363 3462424 + hypothetical protein SCE87.10%2C possible membrane protein%2C len: 353 aa. Weakly similar to Salmonella typhimurium SW:CBIM_SALTY (EMBL:L12006) cobalamin biosynthesis protein CbiM (245 aa)%2C fasta scores opt: 224 z-score: 251.7 E(): 1.2e-06 32.8%25 identity in 180 aa overlap. Also similar to Methanobacterium thermoautotrophicum TR: O27742 (EMBL:AE000928) cobalamin biosynthesis protein M (217 aa)%2C fasta scores opt: 495 z-score: 544.6 E(): 5.9e-23 41.4%25 identity in 220 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence gene gene3179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3159 SCO3160 SCO3160 SCE87.11 SCE87.11 3462426 3463187 + integral membrane transport protein SCE87.11%2C possible integral membrane transport protein%2C len: 253 aa. Similar to many proteins thought to be involved in the transport of cobalt e.g. Streptomyces coelicolor TR:O54188(EMBL:AL021411) cobalt transport integral membrane protein SC7H1.29c (CbiQ) (249 aa)%2C fasta scores opt: 196 z-score: 249.6 E(): 1.6e-06 25.5%25 identity in 251 aa overlap and Methanobacterium thermoautotrophicum TR:O27740(EMBL:AE000928) cobalt transport membrane protein (261 aa)%2C fasta scores opt: 332 z-score: 417.0 E(): 7.5e-16 30.2%25 identity in 212 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene3180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3160 SCO3161 SCO3161 SCE87.12 SCE87.12 3463196 3463978 + ABC transporter ATP-binding protein SCE87.12%2C possible ABC transporter%2C ATP-binding subunit%2C len: 260 aa. Highly similar to many cbiO-like proteins thought to be involved in ATP-dependent cobalt transport e.g. Methanococcus jannaschii TR:Q58488(EMBL:U67551) cobalt transport ATP-binding protein (279 aa)%2C fasta scores opt: 737 z-score: 823.3 E(): 0 45.8%25 identity in 238 aa overlap and Streptomyces coelicolor TR:O54187 (EMBL:AL021411) cobalt transport system ATP binding protein SC7H1.28c (284 aa)%2C fasta scores opt: 664 z-score: 742.6 E():0 44.4%25 identity in 261 aa overlap. Contains a possible membrane spanning hydrophobic domain and a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. Also contains Prosite hits to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3161 SCO3162 SCO3162 SCE87.13 SCE87.13 3463996 3465258 + esterase SCE87.13%2C possible esterase%2C len: 420 aa. Similar to several including: Streptomyces chrysomallus TR:O87861(EMBL:Z15137) esterase A (389 aa)%2C fasta scores opt: 684 z-score: 729.1 E():0 44.9%25 identity in 405 aa overlap and Pseudomonas fluorescens TR:Q53403 (EMBL:S69066) esterase III (382 aa)%2C fasta scores opt: 597 z-score: 637.2 E(): 4e-28 41.8%25 identity in 397 aa overlap. gene gene3182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3162 SCO3163 SCO3163 SCE87.14c SCE87.14c 3465317 3465592 - hypothetical protein SCE87.14c%2C unknown%2C len: 91 aa. Similar to a hypothetical protein from Mycobacterium tuberculosis: SW:YQ32_MYCTU (EMBL:Z80225) hypothetical 10.1 KD protein (93 aa)%2C fasta scores opt: 112 z-score: 161.8 E(): 0.12 31.3%25 identity in 83 aa overlap. gene gene3183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3163 SCO3164 SCO3164 SCE87.15c SCE87.15c 3465682 3466527 - hypothetical protein SCE87.15c%2C possible integral membrane protein%2C len: 281 aa. Weakly similar to Bacillus subtilis SW:YWFM_BACSU (EMBL:X73124) hypothetical 31.3 KD protein in PTA 3'region (296 aa)%2C fasta scores opt: 157 z-score: 184.7 E(): 0.0065 22.9%25 identity in 279 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Also similar to TR:CAC45825 (EMBL:AL591786) Rhizobium meliloti (Sinorhizobium meliloti) hypothetical transmembrane protein SMC01807%2C 278 aa%3B fasta scores: opt: 605 Z-score: 660.4 E(): 3.7e-29%3B 38.811%25 identity in 286 aa overlap gene gene3184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3164 SCO3165 SCO3165 SCE87.16c SCE87.16c 3466524 3467063 - hypothetical protein SCE87.16c%2C unknown%2C len: 179 aa. Weakly similar to several including: Aeropyrum pernix TR:BAA81557 (EMBL: AP000064) 152 aa long hypothetical protein (152 aa)%2C fasta scores opt: 249 z-score: 300.9 E(): 2.2e-09 38.9%25 identity in 131 aa overlap and Streptomyces coelicolor TR:CAB51450 (EMBL:AL096884) transcriptional regulatory protein SC4G6.27 (169 aa)%2C fasta scores opt: 198 z-score: 241.6 E(): 4.4e-06 27.9%25 identity in 129 aa overlap. gene gene3185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3165 SCO3166 SCO3166 SCE87.17c SCE87.17c 3467222 3469459 - membrane transport protein SCE87.17c%2C possible membrane transport protein%2C len: 745 aa. Highly similar to several other Streptomyces coelicolor transport proteins: TR:CAB56653 (EMBL:AL121596) membrane transport protein SCF51A.01C (765 aa)%2C fasta scores opt: 1664 z-score: 1670.0 E(): 0 57.8%25 identity in 760 aa overlap and TR:Q9Z577(EMBL:AL035569) integral membrane export protein SC8D9.13 (748 aa)%2C fasta scores opt: 1382 z-score: 1387.5 E():0 40.7%25 identity in 734 aa overlap. Also similar to a number of other MMPL family membrane proteins such as: Mycobacterium leprae SW:MMLB_MYCLE(EMBL:Z95398) membrane protein MMPL11 (1014 aa)%2C fasta scores opt: 999 z-score: 1001.8 E(): 0 29.6%25 identity in 743 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene3186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3166 SCO3167 SCO3167 SCE87.18c SCE87.18c 3469606 3470205 - TetR family transcriptional regulator SCE87.18c%2C possible tetR-family transcriptional regulator%2C len: 199 aa. Similar to many including: Propionibacterium freudenreichii TR:P72185(EMBL:U51164) repressor protein (HemR protein) (259 aa)%2C fasta scores opt: 222 z-score: 276.8 E(): 4.8e-08 30.6%25 identity in 196 aa overlap and Streptomyces coelicolor TR:CAB45568(EMBL:AL079355) transcriptional regulator (fragment) SC4C6.04 (204 aa)%2C fasta scores opt: 539 z-score: 660.1 E(): 2.2e-29 42.9%25 identity in 191 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene3187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3167 SCO3168 SCO3168 SCE87.19 SCE87.19 3470354 3473869 + protease SCE87.19%2C possible protease%2C len: 1171 aa. Similar to Thermoplasma acidophilum TR:P96086(EMBL:U72850) tricorn protease (1071 aa) opt: 829 z-score: 857.6 E(): 0 28.1%25 identity in 1158 aa overlap and a protein of unknown function from Sulfolobus solfataricus TR:P95871(EMBL: Y08256) ORF C06024 (1068 aa)%2C fasta scores opt: 846 z-score: 875.3 E(): 0 30.3%25 identity in 1150 aa overlap. gene gene3188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3168 SCO3169 SCO3169 SCE87.20c SCE87.20c 3473958 3474185 - hypothetical protein SCE87.20c%2C unknown%2C len: 75 aa. Note the predicted product of this CDS has an unusual amino acid composition with an excess of Arg%2C Asp and Gln residues. gene gene3189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3169 SCO3170 SCO3170 SCE87.21c SCE87.21c 3474274 3475167 - short chain dehydrogenase gene gene3190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3170 SCO3171 SCO3171 SCE87.22c SCE87.22c 3475164 3476108 - hydrolase gene gene3191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3171 SCO3172 SCO3172 SCE87.23c SCE87.23c 3476105 3477664 - monooxygenase SCE87.23c%2C probable monooxygenase%2C len: 519 aa. Highly similar to many including: Acinetobacter sp SW:CYMO_ACISP (EMBL:M19029) cyclohexanone monooxygenase (EC 1.14.13.22) (542 aa)%2C fasta scores opt: 459 z-score: 510.7 E(): 4.5e-21 28.0%25 identity in 511 aa overlap and Mycobacterium tuberculosis TR:O53294(EMBL:AL021287) monooxygenase (524 aa)%2C fasta scores opt: 1522 z-score: 1690.4 E():0 47.4%25 identity in 485 aa overlap. Contains a Pfam match to entry PF00743 FMO-like%2C Flavin-binding monooxygenase-like. gene gene3192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3172 SCO3173 SCO3173 SCE87.24 SCE87.24 3477824 3478471 + MerR family transcriptional regulator SCE87.24%2C possible merR-family transcriptional regulator%2C len: 215 aa. Similar to two other transcriptional regulators from Streptomyces coelicolor TR:CAB40683 (EMBL:AL049587) SC5F2A.16C (251 aa)%2C fasta scores opt: 210 z-score: 257.9 E(): 5.4e-07 32.3%25 identity in 217 aa overlap and TR:O86531 (EMBL:AL031124) SC1C2.31C (214 aa)%2C fasta scores opt: 176 z-score: 218.8 E(): 8.2e-05 30.4%25 identity in 191 aa overlap. Contains a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family with the helix-turn-helix motif situated between residues 8..29 (+3.90 SD). gene gene3193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3173 SCO3174 SCO3174 SCE87.25c SCE87.25c 3478490 3479314 - exodeoxyribonuclease SCE87.25c%2C possible exodeoxyribonuclease (EC 3.1.11.2) (hypothetical protein)%2C len: 274 aa. Highly similar to several e.g. Bacillus subtilis SW:EXOA_BACSU (EMBL:D26185) exodeoxyribonuclease (EC 3.1.11.2) (252 aa)%2C fasta scores opt: 592 z-score: 694.3 E(): 2.7e-31 38.6%25 identity in 267 aa overlap and Methanobacterium thermoautotrophicum TR:O26314 (EMBL:AE000808) exodeoxyribonuclease (257 aa)%2C fasta scores opt: 674 z-score: 789.1 E():0 41.6%25 identity in 262 aa overlap. Also similar to Pseudomonas aeruginosa TR:Q51380 (EMBL:U38241) catabolite repression control protein (259 aa)%2C fasta scores opt: 601 z-score: 704.5 E(): 7.2e-32 39.3%25 identity in 267 aa overlap. Contains a Pfam match to entry PF01260 AP_endonucleas1%2C AP endonuclease family 1. Note that the translational start site may be located at residue 8. Contains possible N-terminal region signal peptide sequence gene gene3194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3174 SCO3175 SCO3175 SCE87.26 SCE87.26 3479362 3479847 + acetyltransferase SCE87.26%2C possible acetyltransferase%2C len: 161 aa. Similar to Azospirillum brasilense SW:IAAT_AZOBR (EMBL:X57853) IAA acetyltransferase (EC 2.3.1.-) (153 aa)%2C fasta scores opt: 224 z-score: 280.9 E(): 2.8e-08 36.7%25 identity in 139 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene3195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3175 SCO3176 SCO3176 SCE87.27c SCE87.27c 3479867 3481618 - hypothetical protein SCE87.27c%2C possible membrane protein%2C len: 583 aa. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene3196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3176 SCO3177 SCO3177 SCE87.28c SCE87.28c 3481968 3483236 - hypothetical protein SCE87.28c%2C possible membrane protein%2C len: 422. Contains possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Also contains a probable coiled-coil between residues 213..240 (28 residues). gene gene3198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3177 SCO3178 SCO3178 SC87.29c SC87.29c 3483413 3484063 - gene gene3199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3178 SCO3179 SCO3179 moaB moaB 3484069 3484608 - molybdenum cofactor biosynthesis protein SCE87.30c%2C moaB%2C probable molybdenum cofactor biosynthesis protein (hypothetical protein)%2C len: 179 aa. Highly similar to many including: Mycobacterium tuberculosis TR:O53877 (EMBL:AL022004) molybdopterin biosynthesis Mog protein (160 aa)%2C fasta scores opt: 617 z-score: 660.3 E(): 2.1e-29 60.0%25 identity in 160 aa overlap and the C-terminus of the Synechococcus sp MoaC%2C MoaB fusion protein SW:MOCB_SYNP7 (EMBL:X99625) molybdenum cofactor biosynthesis protein CB (319 aa)%2C fasta scores opt: 401 z-score: 430.6 E(): 1.3e-16 41.5%25 identity in 171 aa overlap. Contains a Prosite hit to PS01078 Molybdenum cofactor biosynthesis proteins signature 1 and a possible N-terminal signal sequence. gene gene3200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3179 SCO3180 SCO3180 moaC moaC 3484605 3485117 - molybdenum cofactor biosynthesis protein MoaC MoaC%3B along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z%3B involved in molybdenum cofactor biosynthesis gene gene3201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3180 SCO3181 SCO3181 moeA moeA 3485204 3486478 - molybdopterin biosynthesis protein SCE87.32c%2C moeA%2C probable molybdopterin biosynthesis protein. len: 424 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:MOEA_MYCTU (EMBL:Z94752) molybdopterin biosynthesis protein (426 aa)%2C fasta scores opt: 795 z-score: 812.4 E():0 39.3%25 identity in 438 aa overlap. Contains a Pfam match to entry PF00994 MoCF_biosynth%2C Molybdenum cofactor biosynthesis protein. gene gene3202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3181 SCO3182 SCO3182 gtaB gtaB 3486550 3487461 - UTP-glucose-1-phosphate uridylyltransferase SCE87.33c%2C gtaB%2C UTP-glucose-1-phosphate uridylyltransferase%2C len: 303 aa. Highly similar to many proteins belonging to the prokaryotic UDPGP family e.g. Bacillus subtilis SW:GTAB_BACSU (EMBL:L12272) UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (292 aa)%2C fasta scores opt: 907 z-score: 1054.0 E(): 0 47.1%25 identity in 293 aa overlap. Contains a Pfam match to entry PF00483 NTP_transferase%2C Nucleotidyl transferase. gene gene3203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3182 SCO3183 SCO3183 SCE87.34 SCE87.34 3487555 3488169 + 5-formyltetrahydrofolate cyclo-ligase SCE87.34%2C unknown%2C len: 204 aa. Similar to many proteins of undefined function including: Escherichia coli SW:YGFA_ECOLI (EMBL:M12965) hypothetical 21.1 KD protein in SSR-SERA intergenic region (182 aa)%2C fasta scores opt: 298 z-score: 347.9 E(): 5.3e-12 35.0%25 identity in 180 aa overlap. Also weakly similar to several Eukaryotic proteins such as: Homo sapiens SW:FTHC_HUMAN (EMBL: L38928) 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (202 aa)%2C fasta scores opt: 183 z-score: 217.8 E(): 9.3e-05 23.4%25 identity in 188 aa overlap. Contains a Pfam match to entry PF01812 5-FTHF_cyc-lig. gene gene3204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3183 SCO3184 SCO3184 SCE22.01c SCE22.01c 3488258 3491068 - penicillin acylase SCE22.01c%2C possible penicillin acylase (fragment)%2C len: >162 aa%3B similar to C-terminal region of SW:PAC2_PSES3 (EMBL:M18278) Pseudomonas sp. penicillin acylase II precursor (EC 3.5.1.11) AcyII%2C 773 aa%3B fasta scores: opt: 291 z-score: 347.5 E(): 6.8e-12%3B 39.1%25 identity in 110 aa overlap. Contains possible N-terminal signal peptide sequence~SCE87.35c%2C possible penicillin acylase (EC 3.5.1.11) partial CDS%2C len: > 808 aa. Similar to many penicillin acylases including: Pseudomonas sp. (strain SE83) SW:PAC2_PSES3c (EMBL:M18278) penicillin acylase II precursor (EC 3.5.1.11) (penicillin amidase II) (773 aa)%2C fasta scores opt: 308 z-score: 319.7 E(): 2e-10 27.2%25 identity in 815 aa overlap. Contains a Pfam match to entry PF01804 Penicil_amidase and a 12x 'TG' repeat region between residues 148..172. gene gene3205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3184 SCO3185 SCO3185 cvrA cvrA 3491383 3492930 + potassium/proton antiporter the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter%3B can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli gene gene3206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3185 SCO3186 SCO3186 SCE22.03 SCE22.03 3493179 3494444 + ABC transporter SCE22.03%2C possible ABC transporter integral membrane protein%2C len: 421 aa%3B similar to TR:O50532 (EMBL:AL009204) Streptomyces coelicolor hypothetical 41.1 kD protein SC9B10.25c%2C 393 aa%3B fasta scores: opt: 721 z-score: 787.1 E(): 0%3B 34.7%25 identity in 363 aa overlap. Contains match to Prosite entry PS00211 ABC transporters family signature and possible hydrophobic membrane spanning regions gene gene3207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3186 SCO3187 SCO3187 SCE22.04 SCE22.04 3494512 3494844 + hypothetical protein SCE22.04%2C hypothetical protein%2C len: 110 aa%3B similar to TR:O05574 (EMBL:Z94752) Mycobacterium tuberculosis hypothetical 11.4 kD protein MTCI237.05c%2C 110 aa%3B fasta scores: opt: 379 z-score: 372.3 E(): 2.8e-13%3B 52.3%25 identity in 107 aa overlap. High content in serine amino acid residue in C-terminal domain gene gene3208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3187 SCO3188 SCO3188 SCE22.05 SCE22.05 3494975 3495817 + 5'-methylthioadenosine phosphorylase Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate gene gene3209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3188 SCO3189 SCO3189 SCE22.06 SCE22.06 3496079 3496558 + hypothetical protein SCE22.06%2C possible membrane protein%2C len: 159 aa. Contains possible hydrophobic membrane spanning region and high content in alanine amino acid residues gene gene3210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3189 SCO3190 SCO3190 SCE22.07 SCE22.07 3496670 3497140 + mechanosensitive channel SCE22.07%2C probable mechanosensitive channel%2C len: 156 aa%3B similar to TR:Q9Z5G4 (EMBL:AL035500) Mycobacterium leprae gated mechanosensitive ion channel MscL%2C 154 aa%3B fasta scores: opt: 248 z-score: 308.9 E(): 9.6e-10%3B 38.1%25 identity in 147 aa overlap and to SW:MSCL_CLOPE (EMBL:D50309) Clostridium perfringens large-conductance mechanosensitive channel MscL%2C 152 aa%3B fasta scores: opt: 216 z-score: 271.1 E(): 1.2e-07%3B 34.7%25 identity in 124 aa overlap. Contains Pfam match to entry PF01741 MscL%2C Large-conductance mechanosensitive channel%2C MscL and match to Prosite entry PS01327 Large-conductance mechanosensitive channels mscL family signature. Contains also possible hydrophobic membrane spanning regions gene gene3211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3190 SCO3191 SCO3191 SCE22.08c SCE22.08c 3497181 3497357 - hypothetical protein SCE22.08c%2C unknown%2C len: 58 aa gene gene3212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3191 SCO3192 SCO3192 SCE22.09 SCE22.09 3497381 3498703 + hypothetical protein SCE22.09%2C possible integral membrane protein%2C len: 440 aa%3B similar to TR:AAF10839 (EMBL:AE001974) Deinococcus radiodurans conserved hypothetical protein DR1273%2C 429 aa%3B fasta scores: opt: 365 z-score: 385.0 E(): 5.5e-14%3B 28.6%25 identity in 413 aa overlap. High content in alanine amino acid residues. Contains possible hydrophobic membrane spanning regions gene gene3213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3192 SCO3193 SCO3193 SCE22.10 SCE22.10 3498864 3499910 + hypothetical protein SCE22.10%2C hypothetical protein%2C len: 348 aa%3B similar to SW:Y03I_MYCLE (EMBL:U00014) Mycobacterium leprae hypothetical 36.1 kD protein B1549_C2_208%2C 362 aa%3B fasta scores: opt: 894 z-score: 899.8 E(): 0%3B 48.2%25 identity in 365 aa overlap gene gene3214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3193 SCO3194 SCO3194 SCE22.11 SCE22.11 3500071 3501294 + lipoprotein SCE22.11%2C possible lipoprotein%2C len: 407 aa%3B similar to TR:CAB76012 (EMBL:AL157916) Streptomyces coelicolor lipoprotein SC3D11.15%2C 400 aa%3B fasta scores: opt: 1416 z-score: 1518.4 E(): 0%3B 52.4%25 identity in 403 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal domain signal peptide sequence gene gene3215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3194 SCO3195 SCO3195 SCE22.12 SCE22.12 3501532 3502212 + hypothetical protein SCE22.12%2C unknown%2C len: 226 aa gene gene3216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3195 SCO3196 SCO3196 SCE22.13c SCE22.13c 3502247 3504346 - fructose-specific permease SCE22.13c%2C probable fructose-specific permease%2C len: 699 aa%3B similar to SW:PTFB_ECOLI (EMBL:M23196) Escherichia coli PTS system%2C fructose-specific IIBC component (EIIBC-fru) FruA 563 aa%3B fasta scores: opt: 1006 z-score: 1038.9 E(): 0%3B 43.7%25 identity in 583 aa overlap. Contains match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible hydrophobic membrane spanning regions in C-terminal domain gene gene3217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3196 SCO3197 SCO3197 SCE22.14c SCE22.14c 3504474 3505421 - 1-phosphofructokinase SCE22.14c%2C probable 1-phosphofructokinase%2C len: 315 aa%3B similar to SW:K1PF_RHOCA (EMBL:X53150) Rhodobacter capsulatus 1-phosphofructokinase (EC 2.7.1.56) (fructose 1-phosphate kinase) FruK%2C 316 aa%3B fasta scores: opt: 555 z-score: 576.5 E(): 1.2e-24%3B 37.8%25 identity in 315 aa overlap. Contains Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase and match to Prosite entry PS00583 pfkB family of carbohydrate kinases signature 1 gene gene3218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3197 SCO3198 SCO3198 SCE22.15c SCE22.15c 3505418 3506179 - DeoR family transcriptional regulator SCE22.15c%2C probable deoR-family transcriptional regulator%2C len: 253 aa%3B similar to TR:Q9X9X5 (EMBL:AL096743) Streptomyces coelicolor transcriptional regulator SCI7.15%2C 258 aa%3B fasta scores: opt: 609 z-score: 704.8 E(): 8.5e-32%3B 43.1%25 identity in 248 aa overlap and to SW:GATR_ECOLI (EMBL:AE000298) Escherichia coli galactitol utilization operon repressor GatR%2C 259 aa%3B fasta scores: opt: 438 z-score: 509.7 E(): 6.3e-21%3B 33.6%25 identity in 256 aa overlap. Contains Pfam match to entry PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family gene gene3219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3198 SCO3199 SCO3199 SCE22.16c SCE22.16c 3506390 3507907 - transmembrane efflux protein SCE22.16c%2C probable transmembrane efflux protein%2C len: 505 aa%3B similar to SW:AC22_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhodin transporter ActII-2%2C 578 aa%3B fasta scores: opt: 1347 z-score: 1470.8 E(): 0%3B 45.9%25 identity in 442 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and also possible hydrophobic membrane spanning regions gene gene3220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3199 SCO3200 SCO3200 SCE22.17 SCE22.17 3507970 3508941 + DeoR family transcriptional regulator SCE22.17%2C probable deoR-family transcriptional regulator%2C len: 330 aa%3B similar to TR:CAB81864 (EMBL:AL161691) Streptomyces coelicolor deoR-family transcriptional regulator SCD40A.19c%2C 339 aa%3B fasta scores: opt: 682 z-score: 765.6 E(): 0%3B 43.3%25 identity in 298 aa overlap and to Streptomyces coelicolor SC8G12.03c%2C 343 aa%3B fasta scores: opt: 761 z-score: 720.8 E(): 1.3e-34%3B 45.1%25 identity in 326 aa overlap. Contains match to Prosite entry PS00894 Bacterial regulatory proteins%2C deoR family signature and possible helix-turn-helix motif at residues 22..43 (+5.48 SD) gene gene3221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3200 SCO3201 SCO3201 SCE22.18c SCE22.18c 3509244 3509954 - TetR family transcriptional regulator SCE22.18c%2C probable tetR-family transcriptional regulator%2C len: 236 aa%3B similar to TR:CAB62751 (EMBL:AL133424) Streptomyces coelicolor tetR-family transcriptional regulator SCF56.06%2C 213 aa%3B fasta scores: opt: 311 z-score: 346.2 E(): 8e-12%3B 38.1%25 identity in 194 aa overlap and to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR%2C 226 aa%3B fasta scores: opt: 254 z-score: 284.8 E(): 2.1e-08%3B 32.2%25 identity in 214 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 53..74 (+5.22 SD) gene gene3222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3201 SCO3202 SCO3202 hrdD hrdD 3510381 3511379 - RNA polymerase principal sigma factor SCE22.19c%2C hrdD%2C RNA polymerase principal sigma factor%2C len: 332 aa%3B identical to previously sequenced SW:HRDD_STRCO (EMBL:X52982) Streptomyces coelicolor RNA polymerase principal sigma factor HrdD%2C 332 aa. Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and matches to Prosite entries PS00715 Sigma-70 factors family signature 1 and PS00716 Sigma-70 factors family signature 2. Contains also possible helix-turn-helix motif at residues 292..313 (+5.89 SD) gene gene3223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3202 SCO3203 SCO3203 bar bar 3511595 3512110 + phosphinothricin acetyltransferase SCE22.20%2C bar%2C phosphinothricin acetyltransferase%2C len: 171 aa%3B identical to previously sequenced SW:BAR_STRCO (EMBL:M62753) Streptomyces coelicolor phosphinothricin acetyltransferase (EC 2.3.1.-) Bar%2C 171 aa. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene3224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3203 SCO3204 SCO3204 SCE22.21c SCE22.21c 3512143 3512904 - hypothetical protein SCE22.21c%2C unknown%2C len: 253 aa%3B identical to previously sequenced TR:Q54224 (EMBL:X79980) Streptomyces griseus unknown gene%2C 253 aa and similar to SW:YGID_ECOLI (EMBL:M77129) Escherichia coli hypothetical 29.9 kD protein in TolC-RibB intergenic region (ORFC) YgiD%2C 271 aa%3B fasta scores: opt: 566 z-score: 655.8 E(): 4.6e-29%3B 38.5%25 identity in 262 aa overlap gene gene3225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3204 SCO3205 SCO3205 SCE22.22 SCE22.22 3513024 3513515 + MarR family transcriptional regulator SCE22.22%2C probable MarR-family transcriptional repressor%2C len: 163 aa%3B similar to TR:Q9X5U1 (EMBL:AF127374) Streptomyces lavendula repressor MmcW%2C 163 aa%3B fasta scores: opt: 724 z-score: 892.8 E(): 0%3B 65.4%25 identity in 162 aa overlap and to TR:CAB70635 (EMBL:AL137242) Streptomyces coelicolor transcriptional regulator SC8F4.09c%2C 158 aa%3B fasta scores: opt: 409 z-score: 459.2 E(): 4.8e-20%3B 43.2%25 identity in 146 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene3226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3205 SCO3206 SCO3206 SCE22.23c SCE22.23c 3513616 3515160 - transmembrane efflux protein SCE22.23c%2C probable transmembrane efflux protein%2C len: 514 aa%3B similar to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii puromycin resistance protein Pur8%2C 503 aa%3B fasta scores: opt: 1634 z-score: 1768.4 E(): 0%3B 53.1%25 identity in 493 aa overlap and to many other efflux proteins%2C e.g. TR:CAA18346 (EMBL:AL022268) Streptomyces coelicolor transmembrane efflux protein SC4H2.31c%2C 515 aa%3B fasta scores: opt: 1237 z-score: 1139.7 E(): 0%3B 41.0%25 identity in 493 aa overlap. Contains match to Prosite entry PS00216 Sugar transport proteins signature 1 and possible hydrophobic membrane spanning regions gene gene3227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3206 SCO3207 SCO3207 SCE22.24c SCE22.24c 3515302 3516036 - TetR family transcriptional regulator SCE22.24c%2C probable tetR-family transcriptional regulator (fragment)%2C len: >244 aa%3B similar to TR:Q9WX19 (EMBL:AL079345) Streptomyces coelicolor transcriptional regulator SCE68.13%2C 230 aa%3B fasta scores: opt: 305 z-score: 361.2 E(): 1.2e-12%3B 35.2%25 identity in 210 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Contains also possible helix-turn-helix motif at residues 67..88 (+4.22 SD) gene gene3228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3207 SCO3208 SCO3208 SCE8.01 SCE8.01 3516275 3517573 + hypothetical protein SCE8.01%2C possible hypothetical protein%2C len: 432 aa%3B similar to TR:CAC44281 (EMBL:AL596030) Streptomyces coelicolor hypothetical protein SCBAC17F8.09%2C 436 aa%3B fasta scores: opt: 555 Z-score: 578.7 E(): 1.3e-24%3B 33.991%25 identity in 456 aa overlap. Contains a possible N-terminal signal sequence gene gene3229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3208 SCO3209 SCO3209 SCE8.02 SCE8.02 3517633 3519207 + transcriptional regulator SCE8.02%2C possible transcriptional regulator%2C len: 524 aa%3B N-terminal (up to approx. 270aa) similar to one group of transcriptional regulator (eg. SW:ICLR_ECOLI acetate operon repressor from Escherichia coli (274 aa) fasta scores%3B opt: 208%2C z-score: 221.4%2C E(): 5e-05%2C (27.1%25 identity in 262 aa overlap)) and C-terminal (from approx. 270aa) similar to a different group of transcriptional regulator (eg. SW:MHPR_ECOLI mhp operon transcriptional activator (315 aa) fasta scores%3B opt: 205%2C z-score: 217.5%2C E(): 8.3e-05%2C (28.5%25 identity in 267 aa overlap). Both halves appear to be members of the same family of transcriptional regulators (IclR-type) suggesting a duplication event. Contains two probable helix-turn-helix motifs at 37-58aa (Score 1082 (+2.87 SD)) and 320-341aa (Score 1437 (+4.08 SD)). gene gene3230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3209 SCO3210 SCO3210 SCE8.03c SCE8.03c 3519449 3520903 - 3-deoxy-7-phosphoheptulonate synthase SCE8.03c%2C aro%2C probable 2-dehydro-3-deoxyheptonate aldolase%2C len: 484 aa%3B similar to many e.g. TR:O52308 (EMBL:AF035756) 2-dehydro-3-deoxyheptonate aldolase from Streptomyces sp. fasta scores%3B opt: 1619%2C z-score: 1722.0%2C E(): 0%2C (54.5%25 identity in 440 aa overlap) and SW:AROF_ARATH phospho-2-dehydro-3-deoxyheptonate aldolase 1 from Arabidopsis thaliana (525 aa) fasta scores%3B opt: 1457%2C z-score: 1549.2%2C E(): 0%2C (48.4%25 identity in 457 aa overlap). gene gene3231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3210 SCO3211 SCO3211 SCE8.04c SCE8.04c 3520900 3521676 - indoleglycerol phosphate synthase SCE8.04c%2C trpC2%2C probable indoleglycerol phosphate synthase%2C len: 258aa%3B similar to many inluding another from Streptomyces coelicolor TR:O68814 (EMBL:AF054585) located in the trpCBA locus which maps (by hybridisation) to the overlap between cosmids 3A3 and 4G6 (269 aa) fasta scores%3B opt: 652%2C z-score: 740.9%2C E(): 0%2C (47.2%25 identity in 254 aa overlap). Also similar to SW:TRPC_PSEAE trpC%2C probable indoleglycerol phosphate synthase from Pseudomonas aeruginosa (278 aa) fasta scores%3B opt: 632%2C z-score: 718.3%2C E(): 1.1e-32%2C (43.5%25 identity in 260 aa overlap). Contains Pfam match to entry PF00218 IGPS%2C Indole-3-glycerol phosphate synthases%2C score 316.20%2C E-value 3.8e-91. gene gene3232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3211 SCO3212 SCO3212 SCE8.05c SCE8.05c 3521673 3522680 - anthranilate phosphoribotransferase SCE8.05c%2C trpD2%2C anthranilate phosphoribotransferase%2C len: 335 aa%3B similar to many e.g. SW:TRPD_AZOBR TrpD%2C anthranilate phosphoribotransferase from Azospirillum brasilense (355 aa) fasta scores%3B opt: 924%2C z-score: 1056.6%2C E(): 0%2C (49.5%25 identity in 315 aa overlap). Contains Pfam match to entry PF00591 Glycos_transf_3%2C glycosyl transferase family%2C score 223.70%2C E-value 2.8e-63. gene gene3233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3212 SCO3213 SCO3213 SCE8.06c SCE8.06c 3522697 3523299 - anthranilate synthase component II SCE8.06c%2C trpG%2C anthranilate synthase component II%2C len: 200aa%3B similar to many eg. TR:G4185545 (EMBL:AF108766) TrpG%2C anthranilate synthase component II%2C from Rhodobacter sphaeroides (195 aa) fasta scores%3B opt: 728%2C z-score: 825.0%2C E(): 0%2C (60.2%25 identity in 186 aa overlap). Contains matches to Pfam entry PF00117 GATase%2C Glutamine amidotransferases class-I%2C score 332.60%2C E-value 4.3e-96 and Prosite PS00442 Glutamine amidotransferases class-I active site. gene gene3234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3213 SCO3214 SCO3214 SCE8.07c SCE8.07c 3523296 3524831 - anthranilate synthase component I SCE8.07c%2C trpE2%2C anthranilate synthase component I%2C len: 511aa%3B similar to many eg. SW:TRPE_PSEPU TrpE%2C anthranilate synthase component I from Pseudomonas putida (493 aa) fasta scores%3B opt: 1173%2C z-score: 1253.8%2C E(): 0%2C (44.3%25 identity in 492 aa overlap). Contains Pfam match to entry PF00425 chorismate_bind%2C chorismate binding enzyme%2C score 529.40%2C E-value 2.5e-155. gene gene3235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3214 SCO3215 SCO3215 SCE8.08c SCE8.08c 3524828 3525844 - hypothetical protein SCE8.08c%2C unknown%2C len: 338 aa gene gene3236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3215 SCO3216 SCO3216 SCE8.09 SCE8.09 3526137 3528527 + integral membrane ATPase SCE8.09%2C probable integral membrane ATPase%2C len: 796 aa%3B member of a large family including SW:Y1B2_MYCTU cation-transporting ATPase from Mycobacterium tuberculosis (797 aa) fasta scores%3B opt: 2741%2C z-score: 2896.9%2C E(): 0%2C (56.8%25 identity in 791 aa overlap). Contains two Pfam matches to entry PF00122 E1-E2_ATPase%2C E1-E2 ATPases%2C score 109.40%2C E-value 9.7e-30 and score 155.80%2C E-value 7.3e-43%2C and Prosite match to PS00154 E1-E2 ATPases phosphorylation site. gene gene3237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3216 SCO3217 SCO3217 cdaR cdaR 3529272 3531188 + transcriptional regulator SCE8.10%2C cdaR%2C transcriptional activator protein%2C len: 638 aa%3B Previously sequenced and therefore identical to CdaR (EM:AF124138) transcriptional activator protein for the CDA biosynthesis cluster in Streptomyces coelicolor. Also similar to many including SW:AFSR_STRCO AfsR%2C a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2) (993 aa) fasta scores%3B opt: 972%2C z-score: 1087.1%2C E(): 0%2C (36.6%25 identity in 610 aa overlap) and SW:REDD_STRCO regulator of undecylprodigiosin production in Streptomyces coelicolor A3(2) (350 aa) fasta scores%3B opt: 382%2C z-score: 432.2%2C E(): 9.1e-17%2C (32.6%25 identity in 258 aa overlap). Contains match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3217 SCO3218 SCO3218 SCE8.11c SCE8.11c 3531250 3531465 - hypothetical protein SCE8.11c%2C small conserved hypothetical protein%2C len: 71aa%3B similar to others located within antibiotic synthesis clusters egs. TR:O52824 (EMBL:AJ223999) hypothetical protein located within the vancomycin biosynthesis cluster in Amycolatopsis orientalis (56 aa) fasta scores%3B opt: 281%2C z-score: 402.6%2C E(): 4e-15%2C (67.3%25 identity in 52 aa overlap) and SW:YBDZ_ECOLI hypothetical protein located within the enterobactin region of Escherichia coli (72 aa) fasta scores%3B opt: 186%2C z-score: 272.4%2C E(): 7.3e-08%2C (32.8%25 identity in 64 aa overlap). gene gene3239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3218 SCO3219 SCO3219 SCE8.12c SCE8.12c 3531588 3532763 - lipase SCE8.12c%2C possible lipase (hypothetical protein)%2C len: 391 aa%3B weak similarity to many eukaryotic lipases e.g. SW:PAFA_CAVPO platelet-activating factor-acetylhydrolase from guinea pig (Cavia porcellus) (436 aa) fasta scores%3B opt: 153%2C z-score: 161.7%2C E(): 0.11%2C (22.9%25 identity in 319 aa overlap). Contains PS00120 Lipases%2C serine active site. Contains possible N-terminal region signal peptide sequence gene gene3240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3219 SCO3220 SCO3220 SCE8.13c SCE8.13c 3532971 3533399 - hypothetical protein SCE8.13c%2C hypothetical protein%2C len: 142 aa%3B contains alanine-rich N-terminal region and possible N-terminal region signal peptide sequence gene gene3241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3220 SCO3221 SCO3221 SCE8.14c SCE8.14c 3533492 3534346 - prephenate dehydrogenase catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate gene gene3242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3221 SCO3222 SCO3222 SCE8.15c SCE8.15c 3534444 3534899 - hypothetical protein SCE8.15c%2C possible small hypothetical protein%2C len: 169 aa%3B similar to TR:Q9K3L2 (EMBL:AL360055) Streptomyces coelicolor hypothetical protein SCG20A.28c%2C 150 aa%3B fasta scores: opt: 727 Z-score: 859.9 E(): 2.9e-40%3B 72.109%25 identity in 147 aa overlap. Contains possible N-terminal signal sequence gene gene3243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3222 SCO3223 SCO3223 SCE8.16c SCE8.16c 3535054 3535848 - ABC transporter SCE8.16c%2C probable ABC transporter integral membrane protein%2C len: 266aa%3B located directly downstream of a probable ABC transporter ATP-binding protein (6bp gap). Similar to many particularly TR:O86630 (EMBL:AL031155) an integral membrane protein located directly downstream of a probable ABC transporter ATP-binding protein (2bp gap) from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 460%2C z-score: 539.7%2C E(): 9.4e-23%2C (37.0%25 identity in 273 aa overlap). Contains several probable membrane spanning hydrophobic regions. gene gene3244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3223 SCO3224 SCO3224 SCE8.17c SCE8.17c 3535855 3536808 - ABC transporter ATP-binding protein SCE8.17c%2C probable ABC transporter ATP-binding protein%2C len: 317aa%3B similar to many egs. TR:O86629 (EMBL:AL031155) ABC transporter ATP-binding protein from Streptomyces coelicolor (312 aa) fasta scores%3B opt: 1080%2C z-score: 1174.5%2C E(): 0%2C (57.4%25 identity in 303 aa overlap) and SW:BCRA_BACLI bacitracin-resistance ABC transporter from Bacillus licheniformis (306 aa) fasta scores%3B opt: 567%2C z-score: 621.0%2C E(): 2.8e-27%2C (42.4%25 identity in 217 aa overlap). N-terminal region previously sequenced therefore identical to TR:P72389 (EMBL:U51332) partial%2C designated D7 (103 aa) fasta scores%3B opt: 666%2C z-score: 734.8%2C E(): 0%2C (99.0%25 identity in 103 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C score 151.20%2C E-value 1.9e-41 and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3224 SCO3225 SCO3225 absA1 absA1 3536945 3538660 + two component sensor kinase SCE8.18%2C absA1%2C two component sensor kinase%2C len: 571aa%3B sequenced previously therefore identical to TR:Q53893 (EMBL:U51332) AbsA1%2C predicted sensor histidine kinase which acts as part of a two component signal transduction system in the global regulation of antibiotic synthesis in Streptomyces coelicolor (571 aa) fasta scores%3B opt: 3782%2C z-score: 3585.7%2C E(): 0%2C (100.0%25 identity in 571 aa overlap). gene gene3246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3225 SCO3226 SCO3226 absA2 absA2 3538679 3539347 + two component system response regulator SCE8.19%2C absA2%2C two component system response regulator%2C len: 222aa%3B sequenced previously therefore identical to TR:Q53894 (EMBL:U51332) AbsA2%2C predicted response regulator which acts as part of a two component signal transduction system in the global regulation of antibiotic synthesis in Streptomyces coelicolor (222 aa) fasta scores%3B opt: 1376%2C z-score: 1584.1%2C E(): 0%2C (100.0%25 identity in 222 aa overlap). Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain%2C score 138.20%2C E-value 1.5e-37 and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 70.90%2C E-value 2.7e-17. Contains a probable helix-turn-helix motif at 171-192aa (Score 1177 (+3.20 SD)). gene gene3247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3226 SCO3227 SCO3227 SCE63.06 SCE63.06 3539337 3540671 - aminotransferase SCE8.20c%2C partial CDS%2C possible aminotransferase%2C len: 431 aa%3B similar to many of undefined function e.g. TR:O52815 (EMBL:AJ223998) a protein similar to aminotransferase%2C from a cluster of genes involved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (438 aa) fasta scores%3B opt: 953%2C z-score: 1093.1%2C E(): 0%2C (48.4%25 identity in 426 aa overlap). Also similar to TR:Q64602 (EMBL:Z50144) kynurenine/alpha-aminoadipate aminotransferase from rat (Rattus norvegicus) kidney (425 aa) fasta scores%3B opt: 293%2C z-score: 338.4%2C E(): 1.5e-11%2C (25.8%25 identity in 419 aa overlap).~SCE63.06%2C partial CDS%2C possible aminotransferase%2C len: >45 aa%3B similar to the N-terminal region of TR:O52815 (EMBL:AJ223998) a protein similar to aminotransferase from a cluster of genes nvolved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (438 aa) fasta scores%3B opt: 87%2C z-score: 147.0%2C E(): 0.69%2C (45.2%25 identity in 31 aa overlap). The remainder of this CDS lies on the neighbouring Streptomyces coelicolor cosmid E8. gene gene3248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3227 SCO3228 SCO3228 SCE63.05 SCE63.05 3540668 3541801 - glycolate oxidase SCE63.05%2C probable glycolate oxidase%2C len: 377 aa%3B similar to many both prokaryotic and eukaryotic e.g. TR:O52792 (EMBL:AJ223998) similar to glycolate oxidase from a cluster of genes nvolved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (357 aa) fasta scores%3B opt: 995%2C z-score: 998.4%2C E(): 0%2C (47.5%25 identity in 343 aa overlap) and SW:GOX_SPIOL glycolate oxidase from Spinacia oleracea (spinach) (369 aa) fasta scores%3B opt: 917%2C z-score: 920.7%2C E(): 0%2C (41.9%25 identity in 360 aa overlap). Contains Pfam match to entry PF01070 FMN_dh%2C FMN-dependent de hydrogenase%2C score 412.60%2C E-value 3.6e-120 and PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. gene gene3249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3228 SCO3229 SCO3229 SCE63.04 SCE63.04 3541951 3543066 - 4-hydroxyphenylpyruvate dioxygenase SCE63.04%2C probable 4-hydroxyphenylpyruvic acid dioxygenase%2C len: 371 aa%3B similar to many both prokaryotic and eukaryotic e.g. TR:O52791 (EMBL:AJ223998) similar to hydroxyphenyl pyruvate dioxygenase from a cluster of genes involved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (357 aa) fasta scores%3B opt: 989%2C z-score: 1130.3%2C E(): 0%2C (48.7%25 identity in 355 aa overlap) and SW:HPPD_MOUSE hpd%2C 4-hydroxyphenylpyruvic acid dioxygenase from Mus musculus (mouse) (392 aa) fasta scores%3B opt: 610%2C z-score: 698.5%2C E(): 1.3e-31%2C (31.6%25 identity in 361 aa overlap). gene gene3250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3229 SCO3230 SCO3230 cdaPSI cdaPSI 3543335 3565726 + CDA peptide synthetase I SCE63.03c%2C cdaPSI%2C CDA peptide synthetase I%2C len: 7463 aa%3B part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 DUF4%2C Domain of unknown function (U)%2C six separate Pfam matches to entry PF00501 AMP-binding%2C AMP-binding enzyme (A) and six separate Pfam matches to entry PF00550 pp-binding%2C Phosphopantetheine attachment site (P). These Pfam matches cover the full length of the protein in the following order from N to C-terminal U-A-P-U-A-P-U-A-P-U-U-A-P-U-A-P-U-A-P-U. gene gene3251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3230 SCO3231 SCO3231 cdaPS2 cdaPS2 3565723 3576735 + CDA peptide synthetase II SCE63.02c%2C cdaPS2%2C CDA peptide synthetase II%2C len: 3670 aa%3B part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matches to entry PF00668 DUF4%2C Domain of unknown function (U)%2C three separate Pfam matches to entry PF00501 AMP-binding%2C AMP-binding enzyme (A) and three separate Pfam matches to entry PF00550 pp-binding%2C Phosphopantetheine attachment site (P). These Pfam matches cover the full length of the protein in the following order from N to C-terminal U-A-P-U-A-P-U-A-P-U. The first and third Pfam matches to entry PF00501 also contain Prosite matches to PS00455 AMP-binding domain signature. All three Pfam matches to entry PF00550 also contain Prosite matches to PS00012 Phosphopantetheine attachment site. gene gene3252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3231 SCO3232 SCO3232 cdaPS3 cdaPS3 3576735 3583988 + CDA peptide synthetase III SCE63.01%2C partial CDS%2C cdaPS3%2C CDA peptide synthetase III%2C len: >332 aa%3B Constitutes the N-terminus of cdaPS3%2C CDA peptide synthetase III%2C part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible translational coupling. Contains Pfam match to entry PF00668 DUF4%2C Domain of unknown function.~SCE29.01%2C partial CDS%2C cdaPS3%2C CDA peptide synthetase III%2C len: >332aa%3B Constitutes the the majority of cdaPS3%2C CDA peptide synthetase III%2C part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a multifunctional peptide synthetase enzyme. This partial CDS encodes a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible translational coupling. Contains two Pfam matches to entry PF00501 AMP-binding%2C AMP-binding enzyme%2C a Pfam match to entry PF00668 DUF4%2C Domain of unknown function%2C a Pfam match to entry PF00975 Thioesterase%2C Thioesterase domain and two Pfam matches to entry PF00550 pp-binding%2C Phosphopantetheine attachment site. Each PF00501 contains a Prosite match PS00455 AMP-binding domain signature. Each PF00550 contains a Prosite match PS00012 Phosphopantetheine attachment site. gene gene3253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3232 SCO3233 SCO3233 SCE29.0 SCE29.0 3583992 3584810 + hydrolase SCE29.02%2C probable hydrolase%2C len: 272 aa%3B similar to many e.g. TR:O52809 (EMBL:AJ223998) from the vancomycin biosynthesis cluster of Amycolatopsis orientalis (276 aa) fasta scores%3B opt: 892%2C z-score: 1028.9%2C E(): 0%2C (50.9%25 identity in 271 aa overlap) and TR:O67982 (EMBL:AF003947) PcaL%3B single polypeptide combining 3-oxoadipate enol-lactone hydrolyzing and 4-carboxymuconolactone decarboxylating activityfrom Rhodococcus opacus (400 aa) fasta scores%3B opt: 288%2C z-score: 335.4%2C E(): 2.3e-11%2C (32.0%25 identity in 256 aa overlap). Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold%2C score 77.80%2C E-value 2.2e-19. gene gene3254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3233 SCO3234 SCO3234 SCE29.03 SCE29.03 3584822 3585724 + phosphotransferase SCE29.03%2C possible phosphotransferase%2C len: 300 aa%3B weak similarity to TR:P72441 (EMBL:U70376) spectinomycin phosphotransferase from spectinomycin producer Streptomyces flavopersicus (330 aa) fasta scores%3B opt: 145%2C z-score: 177.0%2C E(): 0.015%2C (25.3%25 identity in 261 aa overlap). gene gene3255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3234 SCO3235 SCO3235 SCE29.04c SCE29.04c 3585800 3587647 - ABC transporter SCE29.04c%2C probable ABC transporter%2C len: 615aa%3B similar to many eg. TR:D1035364 (EMBL:AB019513) ABC transporter from Streptomyces coelicolor fasta scores%3B opt: 783%2C z-score: 794.3%2C E(): 0%2C (42.8%25 identity in 596 aa overlap). C-terminal half contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter (score 184.50%2C E-value 1.7e-51) which itself contains Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). N-terminal half contains Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region.%2C score 129.80%2C E-value 4.9e-35. Contains probable transmembrane hydrophobic regions. gene gene3256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3235 SCO3236 SCO3236 SCE29.05c SCE29.05c 3587687 3588688 - oxygenase SCE29.05c%2C possible oxygenase%2C len: 333 aa%3B similar to TR:Q05581 (EMBL:L06213) clavaminate synthase I%2C an alpha-ketoglutarate-dependent oxygenase central to the biosynthesis of clavulanic acid%2C a potent inhibitor of beta-lactamases (324 aa) fasta scores%3B opt: 498%2C z-score: 571.8%2C E(): 1.5e-24%2C (34.3%25 identity in 283 aa overlap). gene gene3257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3236 SCO3237 SCO3237 SCE29.06c SCE29.06c 3588746 3590134 - hypothetical protein SCE29.06c%2C unknown%2C len: 462 aa%3B similar to TR:O69954 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (465 aa) fasta scores%3B opt: 2210%2C z-score: 2646.8%2C E(): 0%2C (70.8%25 identity in 452 aa overlap). gene gene3258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3237 SCO3238 SCO3238 SCE29.07c SCE29.07c 3590146 3591306 - hypothetical protein SCE29.07c%2C unknown%2C len: 386 aa%3B similar to TR:O69953 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (391 aa) fasta scores%3B opt: 1396%2C z-score: 1559.7%2C E(): 0%2C (58.6%25 identity in 389 aa overlap). Contains PS00730 AP endonucleases family 2 signature 2. gene gene3259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3238 SCO3239 SCO3239 SCE29.08c SCE29.08c 3591313 3592182 - hypothetical protein SCE29.08c%2C unknown%2C len: 289 aa%3B similar to TR:O69952 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (282 aa) fasta scores%3B opt: 1391%2C z-score: 1679.9%2C E(): 0%2C (72.3%25 identity in 285 aa overlap). gene gene3260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3239 SCO3240 SCO3240 SCE29.09c SCE29.09c 3592179 3592889 - hypothetical protein SCE29.09c%2C unknown%2C len: 236 aa%3B similar to TR:O69951 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (245 aa) fasta scores%3B opt: 416%2C z-score: 464.9%2C E(): 1.4e-18%2C (45.5%25 identity in 220 aa overlap). gene gene3261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3240 SCO3241 SCO3241 SCE29.10c SCE29.10c 3592886 3593758 - hypothetical protein SCE29.10c%2C possible isomerase%2C len: 290 aa%3B similar to TR:O69950 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (315 aa) fasta scores%3B opt: 1116%2C z-score: 1331.4%2C E(): 0%2C (62.5%25 identity in 283 aa overlap). Also similar to SW:XYLA_STRDI xylose isomerase from Streptomyces diastaticus (388 aa) fasta scores%3B opt: 122%2C z-score: 148.8%2C E(): 0.56%2C25.0%25 identity in 296 aa overlap. gene gene3262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3241 SCO3242 SCO3242 SCE29.11c SCE29.11c 3593755 3594630 - puitative transferase SCE29.11c%2C possible transferase%2C len: 291 aa%3B similar to TR:O69949 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (363 aa) fasta scores%3B opt: 666%2C z-score: 682.9%2C E(): 9.9e-31%2C (51.3%25 identity in 312 aa overlap). Also similar to SW:UBIA_ECOLI 4-hydroxybenzoate octaprenyl transferase from Escherichia coli (290 aa) fasta scores%3B opt: 137%2C z-score: 150.2%2C E(): 0.47%2C (31.8%25 identity in 110 aa overlap). gene gene3263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3242 SCO3243 SCO3243 SCE29.12c SCE29.12c 3594627 3595793 - myo-inositol phosphate synthase SCE29.12c%2C possible myo-inositol phosphate synthase%2C len: 388 aa%3B similar to many e.g. TR:O69948 (EMBL:AL023862) from Streptomyces coelicolor (417 aa) fasta scores%3B opt: 955%2C z-score: 1034.1%2C E(): 0%2C (60.3%25 identity in 380 aa overlap) and SW:INO1_CITPA myo-inositol phosphate synthase from Citrus paradisi (grapefruit) fasta scores%3B opt: 323%2C z-score: 352.1%2C E(): 2.6e-12%2C (26.9%25 identity in 364 aa overlap). gene gene3264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3243 SCO3244 SCO3244 SCE29.13c SCE29.13c 3595843 3596640 - hypothetical protein SCE29.13c%2C hypothetical protein%2C len: 265 aa%3B similar to SW:Y0BO_MYCTU hypothetical protein from Mycobacterium tuberculosis (529 aa) fasta scores%3B opt: 116%2C z-score: 133.8%2C E(): 3.8%2C (38.2%25 identity in 76 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene3265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3244 SCO3245 SCO3245 SCE29.14c SCE29.14c 3596708 3597970 - salicylate hydroxylase SCE29.14c%2C possible salicylate hydroxylase ( hypothetical protein)%2C len: 420 aa%3B similar to many e.g. TR:P96555 (EMBL:AB000564) salicylate hydroxylase from Sphingomonas sp. AJ1 (395 aa) fasta scores%3B opt: 830%2C z-score: 827.2%2C E(): 0%2C (41.9%25 identity in 320 aa overlap) and TR:G4104775 (EMBL:AF039534) salicylate hydroxylase from Pseudomonas stutzeri strain AN10 (389 aa) fasta scores%3B opt: 707%2C z-score: 706.0%2C E(): 5.1e-32%2C (34.7%25 identity in 401 aa overlap). Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase%2C score 91.00%2C E-value 2.4e-23. Contains possible N-terminal region signal peptide sequence gene gene3266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3245 SCO3246 SCO3246 fabH4 fabH4 3598017 3599009 - 3-oxoacyl-ACP synthase III FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs gene gene3267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3246 SCO3247 SCO3247 SCE29.16c SCE29.16c 3599006 3600808 - acyl CoA oxidase SCE29.16c%2C possible acyl CoA oxidase%2C len: 600 aa%3B similar to many acyl CoA oxidases%2C especially from eukaryotes e.g. SW:CAOP_RAT acyl CoA oxidase from Rattus norvegicus (rat) (661 aa) fasta scores%3B opt: 462%2C z-score: 477.6%2C E(): 2.7e-19%2C (27.8%25 identity in 425 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3247 SCO3248 SCO3248 fabF3 fabF3 3600858 3602078 - 3-oxoacyl-ACP synthase SCE29.17c%2C fabF3%2C probable 3-oxoacyl-[acyl carrier protein] synthase II%2C len: 406 aa%3B similar to many e.g. TR:O54149 (EMBL:AL021409) 3-oxoacyl acyl carrier protein synthase II from the Red cluster of Streptomyces coelicolor (407 aa) fasta scores%3B opt: 1217%2C z-score: 1314.2%2C E(): 0%2C (50.1%25 identity in 407 aa overlap) and SW:FABF_ECOLI 3-oxoacyl-[acyl carrier protein] synthase II FabF%2C from Escherichia coli (412 aa) fasta scores%3B opt: 843%2C z-score: 912.2%2C E(): 0%2C (35.4%25 identity in 404 aa overlap). Contains Pfam match to entry PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C score 92.60%2C E-value 7.7e-24 and Prosite match PS00606 Beta-ketoacyl synthases active site. gene gene3269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3248 SCO3249 SCO3249 SCE29.18c SCE29.18c 3602075 3602320 - acyl carrier protein SCE29.18c%2C probable acyl carrier protein%2C len: 81 aa%3B member of a large family including SW:ACP_HELPY acyl carrier protein from Helicobacter pylori (78 aa) fasta scores%3B opt: 121%2C z-score: 179.0%2C E(): 0.012%2C (37.5%25 identity in 64 aa overlap). Contains Pfam match to entry PF00550 pp-binding%2C Phosphopantetheine attachment site%2C score 31.20%2C E-value 5.3e-07. gene gene3270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3249 SCO3250 SCO3250 SCE29.19c SCE29.19c 3602753 3603907 - integrase SCE29.19c%2C probable integrase%2C len: 384aa%3B similar to many eg. SW:INTR_STRAM integrase from the integrated conjugative pSAM plasmid of Streptomyces ambofaciens (388 aa) fasta scores%3B opt: 445%2C z-score: 549.1%2C E(): 2.8e-23%2C (26.8%25 identity in 392 aa overlap). Contains Pfam match to entry PF00589 Phage_integrase%2C 'Phage' integrase family%2C score 88.00%2C E-value 1.9e-22. gene gene3272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3250 SCO3251 SCO3251 SCE29.20c SCE29.20c 3603907 3604107 - excisionase SCE39.01c%2C partial CDS%2C probable excisionase%2C len: >33 aa%3B similar to others eg. TR:E1286473 (EMBL:AJ005260) Xis%2C excisionase fron the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (62 aa) fasta scores%3B opt: 143%2C z-score: 280.9%2C E(): 2.4e-08%2C (96.0%25 identity in 25 aa overlap).~SCE29.20c%2C probable excisionase%2C len: 66 aa%3B highly similar to SW:VXIS_STRAM excisionase from the integrated conjugative pSAM plasmid of Streptomyces ambofaciens (62 aa) fasta scores%3B opt: 290%2C z-score: 444.1%2C E(): 2e-17%2C (80.7%25 identity in 57 aa overlap). gene gene3273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3251 SCO3252 SCO3252 repSA repSA 3604104 3605504 - replication initiator protein SCE39.02c%2C repSA%2C replication initiator protein%2C len: 466 aa%3B highly similar to TR:E1288125 (EMBL:AJ005260) RepSA%2C replication initiator protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (459 aa) fasta scores%3B opt: 2822%2C z-score: 3195.3%2C E(): 0%2C (89.5%25 identity in 455 aa overlap) and TR:E1355655 (EMBL:AL034355) plasmid replication initiator protein from Streptomyces coelicolor (452 aa) fasta scores%3B opt: 732%2C z-score: 831.1%2C E(): 0%2C (45.8%25 identity in 459 aa overlap). gene gene3274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3252 SCO3253 SCO3253 SCE39.03c SCE39.03c 3605594 3605911 - SpdD protein SCE39.03c%2C SpdD protein%2C len: 105aa%3B highly similar to TR:Q07196 (EMBL:AJ005260) SpdD protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (104 aa) fasta scores%3B opt: 491%2C z-score: 476.3%2C E(): 3.2e-19%2C (72.1%25 identity in 104 aa overlap). Contains possible membrane spanning regions gene gene3275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3253 SCO3254 SCO3254 SCE39.04c SCE39.04c 3605935 3606090 - SpdC protein SCE39.04c%2C SpdC protein%2C len: 51 aa%3B highly similar to TR:Q07195 (EMBL:AJ005260) SpdC protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (51 aa) fasta scores%3B opt: 286%2C z-score: 418.6%2C E(): 5.2e-16%2C (80.4%25 identity in 51 aa overlap). Largely hydrophobic suggesting membrane association. Contains possible hydrophobic membrane spanning region gene gene3276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3254 SCO3255 SCO3255 SCE39.05c SCE39.05c 3606102 3606263 - SpdB protein SCE39.05c%2C SpdB protein%2C len: 53 aa%3B highly similar to TR:Q07194 (EMBL:AJ005260) SpdB protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (58 aa) fasta scores%3B opt: 291%2C z-score: 448.0%2C E(): 1.2e-17%2C (83.3%25 identity in 48 aa overlap). gene gene3277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3255 SCO3256 SCO3256 SCE39.06c SCE39.06c 3606326 3606979 - SpdA protein SCE39.06c%2C SpdA protein%2C len: 217 aa%3B highly similar to TR:Q07193 (EMBL:AJ005260) SpdA protein form the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (224 aa) fasta scores%3B opt: 1071%2C z-score: 973.6%2C E(): 0%2C (75.6%25 identity in 225 aa overlap). Contains possible membrane spanning regions and a possible N-terminal region signal sequence peptide gene gene3278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3256 SCO3257 SCO3257 SCE39.07c SCE39.07c 3607061 3608416 - plasmid transfer protein SCE39.07c%2C traSA%2C plasmid transfer protein%2C len: 451 aa%3B similar to many from Streptomyces spp. eg. TR:O69803 (EMBL:AJ005260) from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (415 aa) fasta scores%3B opt: 2515%2C z-score: 2911.8%2C E(): 0%2C (90.6%25 identity in 415 aa overlap) and TR:O86766 (EMBL:AL031035) TraSA integrase fusion protein from the Streptomyces coelicolor cosmid 6A9 (768 aa) fasta scores%3B opt: 2418%2C z-score: 2795.6%2C E(): 0%2C (89.1%25 identity in 405 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains strongly hydrophilic peak at about aa 300 and TTA codon%2C possible target for bldA regulation. FtsK/SpoIIIE family member. gene gene3279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3257 SCO3258 SCO3258 pra pra 3608420 3608776 - regulatory protein SCE39.08c%2C pra%2C regulatory protein%2C len: 118 aa%3B highly similar to TR:Q53733 (EMBL:AJ005260) Pra%2C a protein found to have a regulatory function in the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (116 aa) fasta scores%3B opt: 655%2C z-score: 836.5%2C E(): 0%2C (88.1%25 identity in 118 aa overlap). Also highly similar to and apparently frameshifted (with high confidence in sequence) gene TR:O86764 and TR:O86765 (EMBL:AL031035) from Streptomyces coelicolor cosmid 6A9 fasta scores for TR:O86764%3B opt: 348%2C z-score: 456.1%2C E(): 4.3e-18%2C (88.7%25 identity in 62 aa overlap) and TR:O86765%3B opt: 259%2C z-score: 347.5%2C E(): 4.8e-12%2C (87.2%25 identity in 47 aa overlap). gene gene3280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3258 SCO3259 SCO3259 korSA korSA 3608916 3609695 - korSA%2C regulatory protein SCE39.09c%2C korSA%2C regulatory protein%2C len: 259 aa%3B highly similar to TR:Q07191 (EMBL:AJ005260) KorSA%2C regulatory protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (259 aa) fasta scores%3B opt: 1669%2C z-score: 1948.2%2C E(): 0%2C (98.5%25 identity in 259 aa overlap) and TR:O86763 (EMBL:AL031035) regulatory protein from Streptomyces coelicolor cosmid SC6A9 (259 aa) fasta scores%3B opt: 1655%2C z-score: 1931.9%2C E(): 0%2C (96.9%25 identity in 259 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene3281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3259 SCO3260 SCO3260 SCE39.10 SCE39.10 3609789 3610178 + MutT-like protein SCE39.10%2C MutT-like protein%2C len: 129aa%3B highly similar to TR:O69802 (EMBL:AJ005260) from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (131 aa) fasta scores%3B opt: 813%2C z-score: 1042.9%2C E(): 0%2C (94.6%25 identity in 129 aa overlap) and TR:O86762 (EMBL:AL031035) from Streptomyces coelicolor cosmid 6A9 (131 aa) fasta scores%3B opt: 804%2C z-score: 1031.5%2C E(): 0%2C (93.8%25 identity in 129 aa overlap). Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and Prosite match to PS00893 mutT domain signature. gene gene3282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3260 SCO3261 SCO3261 SCE39.11 SCE39.11 3610876 3612171 + ATP-binding protein SCE39.11%2C possible ATP-binding protein%2C len: 431 aa%3B limited similarity to others of unknown function eg. TR:Q47527 (EMBL:Z12832) hypothetical ATP-binding protein from Escherichia coli (492 aa) fasta scores%3B opt: 239%2C z-score: 271.8%2C E(): 7.9e-08%2C (32.0%25 identity in 153 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3261 SCO3262 SCO3262 SCE39.12 SCE39.12 3612168 3612917 + hypothetical protein SCE39.12%2C unknown%2C len: 249aa%3B limited similarity to others of unknown function some of which are associated with bacteriophage eg. SW:VE31_LAMBD protein EA31 from bacteriophage lambda (296 aa) fasta scores%3B opt: 133%2C z-score: 164.9%2C E(): 0.071%2C (35.3%25 identity in 85 aa overlap). Contains TTA codon%2C possible target for bldA regulation. gene gene3284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3262 SCO3263 SCO3263 SCE39.13c SCE39.13c 3613332 3613631 - hypothetical protein SCE39.13c%2C unknown%2C len: 99 aa%3B similar to TR:CAC44711 (EMBL:AL596251) Streptomyces coelicolor conserved hypothetical protein SCBAC25E3.24%2C 101 aa%3B fasta scores: opt: 441 Z-score: 540.6 E(): 1.8e-22%3B 67.742%25 identity in 93 aa overlap. Contains possible coiled-coil region gene gene3285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3263 SCO3264 SCO3264 SCE39.14c SCE39.14c 3613628 3614359 - GntR family transcriptional regulator SCE39.14c%2C possible gntR-family regulator%2C len: 243aa%3B weak similarity to many egs. SW:FARR_ECOLI fatty acyl responsive regulator from Escherichia coli (240 aa) fasta scores%3B opt: 196%2C z-score: 243.9%2C E(): 2.8e-06%2C (24.3%25 identity in 243 aa overlap) and SW:KORA_STRLI KorA protein found to control plasmid transfer in the Streptomyces lividans plasmid pIJ101 (241 aa) fasta scores%3B opt: 158%2C z-score: 198.3%2C E(): 0.00098%2C (22.0%25 identity in 227 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and Prosite match to PS00043 Bacterial regulatory proteins%2C gntR family signature. Also contains probable helix-turn-helix (+3.94 SD) 29-50aa gene gene3286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3264 SCO3265 SCO3265 SCE39.15c SCE39.15c 3614368 3614592 - hypothetical protein SCE39.15c%2C unknown%2C len: 74aa%3B similar to TR:CAC44709 (EMBL:AL596251) conserved hypothetical protein SCBAC25E3.22 from Streptomyces coelicolor (74 aa) fasta scores%3B opt: 356%2C Z-score: 489.1%2C E(): 1.3e-19%2C 77.465%25 identity (77.465%25 ungapped) in 71 aa overlap. gene gene3287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3265 SCO3266 SCO3266 SCE39.16c SCE39.16c 3614589 3614792 - hypothetical protein SCE39.16c%2C unknown%2C len: 67aa gene gene3288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3266 SCO3267 SCO3267 SCE39.17 SCE39.17 3614834 3615034 + hypothetical protein SCE39.17%2C unknown%2C len: 66aa gene gene3289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3267 SCO3268 SCO3268 SCE39.18c SCE39.18c 3615122 3615400 - hypothetical protein SCE39.18c%2C hypothetical protein%2C len: 92 aa%3B similar to TR:CAC44706 (EMBL:AL596251) Streptomyces coelicolor conserved hypothetical protein SCBAC25E3.19%2C 92 aa%3B fasta scores: opt: 471 Z-score: 603.7 E(): 5.4e-26l%3B 81.522%25 identity in 92 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3268 SCO3269 SCO3269 SCE39.19 SCE39.19 3615480 3616235 + GntR family transcriptional regulator SCE39.19%2C possible gntR-family regulator%2C len: 251 aa%3B some similarity to many egs. TR:Q07191 (EMBL:AJ005260) KorSA protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (259 aa) fasta scores%3B opt: 327%2C z-score: 380.9%2C E(): 6.7e-14%2C (31.0%25 identity in 252 aa overlap) and TR:O86763 (EMBL:AL031035) KorSA transcriptional regulator from Streptomyces coelicolor cosmid 6A9 (259 aa) fasta scores%3B opt: 326%2C z-score: 379.7%2C E(): 7.7e-14%2C (28.9%25 identity in 249 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. Also contains probable helix-turn-helix (+4.51 SD) 31-52aa. gene gene3291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3269 SCO3270 SCO3270 SCE39.20 SCE39.20 3616286 3616798 + hypothetical protein SCE39.20%2C unknown%2C len: 170aa gene gene3292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3270 SCO3271 SCO3271 SCE39.21 SCE39.21 3617075 3617377 + dehydrogenase SCE39.21%2C possible dehydrogenase%2C len: 100aa%3B similar to TR:Q53783 (EMBL:L33871) vdh%2C valine dehydrogenase from Streptomyces ambofaciens (120 aa) fasta scores%3B opt: 92%2C z-score: 127.5%2C E(): 8.6%2C (29.9%25 identity in 107 aa overlap). gene gene3293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3271 SCO3272 SCO3272 SCE39.22c SCE39.22c 3617612 3617980 - DNA-binding protein SCE39.22c%2C possible DNA-binding protein%2C len: 122aa%3B some similarity to TR:O64356 (EMBL:AF064539) Gp48 protein from bacteriophage N15 (95 aa) fasta scores%3B opt: 114%2C z-score: 155.2%2C E(): 0.25%2C (36.6%25 identity in 71 aa overlap). Contains probable helix-turn-helix (+6.85 SD) 82-103aa. gene gene3294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3272 SCO3273 SCO3273 SCE39.23 SCE39.23 3618213 3618479 + hypothetical protein SCE39.23%2C unknown%2C len: 88aa%3B contains possible coiled-coil. gene gene3295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3273 SCO3274 SCO3274 SCE39.24 SCE39.24 3618476 3618922 + hypothetical protein SCE39.24%2C unknown%2C len: 148aa gene gene3296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3274 SCO3275 SCO3275 SCE39.25c SCE39.25c 3619017 3619469 - MerR family transcriptional regulator SCE39.25c%2C possible merR-family transcriptional regulator%2C len: 150 aa%3B similar to many e.g. SW:MERR_BACSR MerR%2C mercury resistance operon transcriptional regulator from Bacillus subtilis (132 aa) fasta scores%3B opt: 201%2C z-score: 245.2%2C E(): 2.4e-06%2C (40.3%25 identity in 77 aa overlap) and SW:TIPA_STRLI TipA%2C transcriptional activator of a thiostrepton-induced gene in Streptomyces lividans (253 aa) fasta scores%3B opt: 196%2C z-score: 235.4%2C E(): 8.4e-06%2C (35.5%25 identity in 107 aa overlap). Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and Prosite match to PS00552 Bacterial regulatory proteins%2C merR family signature. Also contains probable helix-turn-helix (+3.27 SD) 13-34 aa gene gene3297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3275 SCO3276 SCO3276 SCE39.26 SCE39.26 3619892 3621391 + integral membrane transporter SCE39.26%2C possible integral membrane transporter%2C len: 499aa%3B similar to many eg. TR:Q50443 (EMBL:U50335) ORF2 from Mycobacterium smegmatis (498 aa) fasta scores%3B opt: 2027%2C z-score: 2225.4%2C E(): 0%2C (64.0%25 identity in 478 aa overlap) and TR:O07488 (EMBL:Y13308) proposed sulphate permease from Yersinia enterocolitica (492 aa) fasta scores%3B opt: 1564%2C z-score: 1718.0%2C E(): 0%2C (51.0%25 identity in 482 aa overlap). Contains Pfam match to entry PF00916 Sulfate_transp%2C Sulfate transporter family. Also contains several possible membrane spanning hydrophobic regions. gene gene3298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3276 SCO3277 SCO3277 SCE39.27c SCE39.27c 3621404 3622270 - phosphotransferase SCE39.27c%2C possible phosphotransferase%2C len: 288aa%3B similar to many antibiotic phosphotransferases eg. TR:Q53826 (EMBL:U13078) capreomycin phosphotransferase from Streptomyces capreolus (281 aa) fasta scores%3B opt: 157%2C z-score: 183.5%2C E(): 0.0065%2C (28.3%25 identity in 226 aa overlap). gene gene3299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3277 SCO3278 SCO3278 SCE39.28 SCE39.28 3622465 3622593 + hypothetical protein SCE39.28%2C unknown%2C len: 42aa gene gene3300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3278 SCO3279 SCO3279 SCE39.29 SCE39.29 3622590 3623804 + integral membrane efflux protein SCE39.29%2C possible integral membrane efflux protein%2C len: 404aa%3B similar to many eg. SW:KEFB_ECOLI glutathione-regulated potassium-efflux system protein%2C KefB (601 aa) fasta scores%3B opt: 250%2C z-score: 293.4%2C E(): 5e-09%2C (27.1%25 identity in 414 aa overlap). Contains several potential membrane spanning hydrophobic regions. gene gene3301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3279 SCO3280 SCO3280 SCE39.30 SCE39.30 3623801 3624412 + hypothetical protein SCE39.30%2C membrane protein%2C len: 203 aa%3B similar to another from Streptomyces coelicolor cosmid 5C7 TR:O86731 (EMBL:AL031515) hypothetical protein (314 aa) fasta scores%3B opt: 163%2C z-score: 187.7%2C E(): 0.0038%2C (31.8%25 identity in 154 aa overlap). Contains histidine-rich N-terminal region. Contains possible hydrophobic membrane spanning regions gene gene3302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3280 SCO3281 SCO3281 SCE39.31c SCE39.31c 3624449 3624859 - hypothetical protein SCE39.31c%2C unknown%2C len: 136aa%3B similar to TR:O68643 (EMBL:AF052749) hypothetical protein from Pseudomonas putida (109 aa) fasta scores%3B opt: 359%2C z-score: 415.3%2C E(): 8.1e-16%2C (41.3%25 identity in 109 aa overlap). gene gene3303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3281 SCO3282 SCO3282 cobH cobH 3625007 3625663 + precorrin-8X methylmutase catalyzes the interconversion of precorrin-8X and hydrogenobyrinate gene gene3304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3282 SCO3283 SCO3283 cbiJ cbiJ 3625695 3626462 - cobalt-precorrin-6x reductase CobK/CbiJ%3B there are 2 pathways for cobalamin (vitamin B12) production%2C one aerobic (ex. P. denitrificans)%2C the other anaerobic (ex. S. typhimurium)%3B the CobK/CbiJ perform similar reactions in both%3B the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur%3B CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 gene gene3305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3283 SCO3284 SCO3284 SCE15.01 SCE15.01 3626633 3628768 + hypothetical protein SCE15.01%2C partial CDS%2C conserved hypothetical protein%2C len: >436aa%3B similar to C-terminal region of TR:CAA22732 (EMBL:AL035161) another conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores%3B opt: 922%2C z-score: 1011.5%2C E(): 0%2C (39.5%25 identity in 425 aa overlap).~SCE39.34%2C unknown%2C len: >307aa%3B similar to TR:E1370406 (EMBL:AL035161) conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores%3B opt: 254%2C z-score: 277.0%2C E(): 4e-08%2C (29.2%25 identity in 277 aa overlap) TR:O86875 (EMBL:U22894) hypothetical protein from Streptomyces lividans (547 aa) fasta scores%3B opt: 226%2C z-score: 249.7%2C E(): 1.3e-06%2C (33.0%25 identity in 197 aa overlap). gene gene3306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3284 SCO3285 SCO3285 SCE15.02c SCE15.02c 3628805 3634123 - large glycine/alanine rich protein SCE15.02c%2C large glycine/alanine rich protein%2C len: 1772aa gene gene3307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3285 SCO3286 SCO3286 SCE15.03c SCE15.03c 3634209 3636242 - hypothetical protein SCE15.03%2C hypothetical protein%2C len: 677 aa%3B weak similarity to SW:YQIK_ECOLI hypothetical protein from Escherichia coli (553 aa) fasta scores%3B opt: 542%2C z-score: 501.2%2C E(): 1.3e-20%2C (27.0%25 identity in 504 aa overlap). Contains possible N-terminal region signal peptide sequence also contains a highly hidrophilic central part of the protein gene gene3308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3286 SCO3287 SCO3287 SCE15.04 SCE15.04 3636329 3636847 + serine/arginine rich protein SCE15.04%2C serine/arginine rich protein%2C len: 172aa gene gene3309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3287 SCO3288 SCO3288 SCE15.05 SCE15.05 3636856 3637587 + hypothetical protein SCE15.05%2C possible integral membrane protein%2C len: 243aa%3B similar to TR:Q53715 (EMBL:L06249) hypothetical protein from Streptomyces antibioticus (234 aa) fasta scores%3B opt: 292%2C z-score: 298.6%2C E(): 2.5e-09%2C (33.2%25 identity in 241 aa overlap). Contains a possible membrane spanning hydrophobic region and a 8x5 degenerate repeat of GT***. gene gene3310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3288 SCO3289 SCO3289 SCE15.06 SCE15.06 3637594 3639204 + large membrane protein SCE15.06%2C possible large membrane protein%2C len: 536 aa%3B contains a possible membrane spanning hydrophobic region gene gene3311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3289 SCO3290 SCO3290 SCE15.07 SCE15.07 3639201 3639950 + hypothetical protein SCE15.07%2C unknown%2C len: 249aa gene gene3312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3290 SCO3291 SCO3291 SCE15.08 SCE15.08 3640178 3641611 + regulatory protein SCE15.08%2C possible regulatory protein%2C len: 477 aa%3B N-terminal region similar to others from Actinomycetes eg. SW:DNRI_STRPE regulatory protein from Streptomyces peucetius (272 aa) fasta scores%3B opt: 143%2C z-score: 162.9%2C E(): 0.092%2C (27.8%25 identity in 241 aa overlap). gene gene3313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3291 SCO3292 SCO3292 SCE15.09c SCE15.09c 3641739 3642248 - hypothetical protein SCE15.09c%2C unknown%2C len: 169aa gene gene3314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3292 SCO3293 SCO3293 SCE15.10c SCE15.10c 3642308 3642811 - small integral membrane protein SCE15.10c%2C possible small integral membrane protein%2C len: 167aa%3B contains a possible membrane spanning hydrophobic region. gene gene3315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3293 SCO3294 SCO3294 SCE15.11c SCE15.11c 3642817 3644163 - transferase SCE15.11c%2C possible transferase%2C len: 448aa%3B weak similarity to SW:MTRD_METMA N5-methyltetrahydromethanopterin coenzyme M methyltransferase from Methanosarcina mazei (250 aa) fasta scores%3B opt: 126%2C z-score: 151.3%2C E(): 0.41%2C (26.3%25 identity in 137 aa overlap). Contains TTA leucine codon in the N-terminal region - possible target for bldA regulation. gene gene3316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3294 SCO3295 SCO3295 SCE15.12c SCE15.12c 3644267 3644935 - oxidoreductase SCE15.12c%2C possible oxidoreductase%2C len: 222aa%3B similar to TR:O85762 (EMBL:AF075709) NADH dependent FMN reductase from Pseudomonas putida (200 aa) fasta scores%3B opt: 208%2C z-score: 241.1%2C E(): 4e-06%2C (35.7%25 identity in 129 aa overlap). gene gene3317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3295 SCO3296 SCO3296 SCE15.13c SCE15.13c 3644932 3646035 - oxidoreductase SCE15.13c%2C possible oxidoreductase%2C len: 367aa%3B some similarity to TR:CAA77275 (EMBL:Y18729) F420-dependent alcoholdehydrogenase from Methanoculleus thermophilicus (330 aa) fasta scores%3B opt: 211%2C z-score: 252.%2C1 E(): 9.9e-07%2C (29.0%25 identity in 183 aa overlap). gene gene3318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3296 SCO3297 SCO3297 SCE15.14 SCE15.14 3646131 3646469 + hypothetical protein SCE15.14%2C membrane protein%2C len: 112 aa%3B similar to others e.g. SW:YQ09_MYCTU (EMBL:Z80225) Mycobacterium tuberculosis hypothetical protein (110 aa) fasta scores%3B opt: 597%2C z-score: 741.6%2C E(): 0%2C (73.1%25 identity in 108 aa overlap) Contains possible hydrophobic membrane spanning regions gene gene3319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3297 SCO3298 SCO3298 SCE15.15 SCE15.15 3646539 3647321 + oxidoreductase SCE15.15%2C possible oxidoreductase%2C len: 260aa%3B similar to many egs. SW:YV10_MYCTU oxidoreductase from Mycobacterium tuberculosis (251 aa) fasta scores%3B opt: 826%2C z-score: 880.1%2C E():0%2C (57.2%25 identity in 243 aa overlap) and TR:O54197 (EMBL:AJ000671) clavulanate-9-aldehyde reductase from Streptomyces clavuligerus (247 aa) fasta scores%3B opt: 493%2C z-score: 530.5%2C E(): 3.1e-22%2C (39.8%25 identity in 249 aa overlap). Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene3320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3298 SCO3299 SCO3299 SCE15.16c SCE15.16c 3647355 3648548 - hypothetical protein SCE15.16c%2C unknown%2C len: 397aa%3B similar to many e.g. SW:RTCB_ECOLI hypothetical protein from Escherichia coli (408 aa) fasta scores%3B opt: 809%2C z-score: 903.2%2C E(): 0%2C 46.8%25 identity in 408 aa overlap. Contains Pfam match to entry PF01139 UPF0027%2C Uncharacterized protein family UPF0027. gene gene3321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3299 SCO3300 SCO3300 SCE15.17 SCE15.17 3648648 3649631 + hypothetical protein SCE15.17%2C possible serine-rich protein%2C len: 320aa%3B contains possible N-terminal signal sequence. gene gene3322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3300 SCO3301 SCO3301 SCE15.18 SCE15.18 3649764 3650615 + hypothetical protein SCE15.18%2C possible hypothetical protein%2C len: 283aa%3B contains possible N-terminal signal sequence. gene gene3323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3301 SCO3302 SCO3302 SCE15.19 SCE15.19 3650705 3652006 + hypothetical protein SCE15.19%2C possible integral membrane protein%2C len: 433aa%3B contains possible membrane spanning hydrophobic regions. gene gene3324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3302 SCO3303 SCO3303 lysK lysK 3652259 3654001 - lysyl-tRNA synthetase class I%3B LysRS1%3B catalyzes a two-step reaction%2C first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine gene gene3325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3303 SCO3304 SCO3304 argS argS 3654175 3655935 + arginyl-tRNA synthetase catalyzes a two-step reaction%2C first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B class-I aminoacyl-tRNA synthetase gene gene3326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3304 SCO3305 SCO3305 SCE68.03 SCE68.03 3656071 3657396 + acyltransferase SCE68.03%2C possible membrane protein%2C len: 441 aa%3B unknown function%2C weakly similar to TR:O66257 (EMBL:AB010415) Actinobacillus actinomycetemcomitans integral membrane acetyltransferase (344 aa)%2C fasta scores%3B opt: 259 z-score: 247.1 E(): 1.9e-06%2C 24.2%25 identity in 360 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene3327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3305 SCO3306 SCO3306 SCE68.04c SCE68.04c 3657329 3658543 - aminotransferase SCE68.04c%2C possible aminotransferase%2C len: 404 aa%3B similar to TR:Q56232 (EMBL:D38459)%2C aspC%2C Thermus aquaticus aspartate aminotransferase (385 aa)%2C fasta scores%3B opt: 379 z-score: 433.6 E(): 7.9e-17%2C 28.9%25 identity in 370 aa overlap and to many hypothetical aminotransferases. Similar to many from S.coelicolor e.g. SCH10.36 (EMBL:AL049754) probable aspartate aminotransferase (396 aa) (33.2%25 identity in 404 aa overlap). Alternative start codons are present at codons 3 and 7. Contains Pfam match to entry PF00155 aminotran_1%2C Aminotransferases class-I gene gene3328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3306 SCO3307 SCO3307 SCE68.05c SCE68.05c 3658635 3659537 - hypothetical protein SCE68.05c%2C conserved hypothetical protein%2C len: 300 aa%3B unknown function%2C similar to others from S.coelicolor e.g. TR:O86541 (EMBL:AL031350)%2C SC1F3.04%2C hypothetical protein (261 aa)%2C fasta scores%3B opt: 791 z-score: 916.0 E(): 0%2C 48.9%25 identity in 262 aa overlap gene gene3329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3307 SCO3308 SCO3308 SCE68.06c SCE68.06c 3659641 3661035 - DNA-binding protein SCE68.06c%2C probable DNA-binding protein%2C len: 464 aa%3B similar to TR:Q9AK04 (EMBL:AL512944) Streptomyces coelicolor hypothetical protein SC8D11.15c%2C 471 aa%3B fasta scores: opt: 428 Z-score: 331.6 E(): 7.7e-11%3B 40.377%25 identity in 478 aa overlap%3B probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains a hydrophobic%2C possible membrane-spanning region%2C followed by a low-complexity proline- and serine-rich region from aa 210 to 250 approx. Contains probable helix-turn-helix motif at aa 20-41 (Score 1605%2C +4.65 SD) gene gene3330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3308 SCO3309 SCO3309 SCE68.07c SCE68.07c 3661178 3661555 - hypothetical protein SCE68.07c%2C hypothetical protein%2C len: 125 aa%3B unknown function%2C probable CDS suggested by GC frame analysis and amino acid composition gene gene3331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3309 SCO3310 SCO3310 SCE68.08 SCE68.08 3661737 3661991 + hypothetical protein SCE68.08%2C hypothetical protein%2C len: 84 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3310 SCO3311 SCO3311 hemB hemB 3662050 3663042 - delta-aminolevulinic acid dehydratase catalyzes the formation of porphobilinogen from 5-aminolevulinate gene gene3333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3311 SCO3312 SCO3312 SCE68.10 SCE68.10 3663566 3663976 + hypothetical protein SCE68.10%2C hypothetical protein%2C len: 136 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Similar to TRNEW:CAC46514 (EMBL:AL591789) hypothetical protein SMC04265 from Rhizobium meliloti (Sinorhizobium meliloti) (147 aa) fasta scores%3B opt: 380%2C Z-score: 458.7%2C E(): 6.5e-18%2C 46.875%25 identity (47.244%25 ungapped) in 128 aa overlap. gene gene3334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3312 SCO3313 SCO3313 SCE68.11 SCE68.11 3663973 3664890 - hypothetical protein SCE68.11c%2C conserved hypothetical protein%2C len: 305 aa%3B unknown function%2C N-terminal half similar to hypothetical proteins from Mycobacterium tuberculosis%2C Mycobacterium paratuberculosis and Streptomyces lividans%2C e.g. SW:Y08L_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical protein (149 aa)%2C fasta scores%3B opt: 297 z-score: 354.1 E(): 2.1e-12%2C 42.7%25 identity in 124 aa overlap gene gene3335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3313 SCO3314 SCO3314 SCE68.12c SCE68.12c 3665180 3666136 - dehydrogenase SCE68.12c%2C possible dehydrogenase%2C len: 318 aa%3B weakly similar to SW:QOR_CAVPO (EMBL:M26936) Cavia porcellus quinone oxidoreductase (329 aa)%2C fasta scores%3B opt: 301 z-score: 320.4 E(): 1.6e-10%2C 27.6%25 identity in 326 aa overlap. Similar to TR:Q53927 (EMBL:X62373) ORF2 from S.coelicolor actVI locus (329 aa) (33.7%25 identity in 329 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene3336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3314 SCO3315 SCO3315 SCE68.13 SCE68.13 3666265 3666957 + transcriptional regulator SCE68.13%2C probable transcriptional regulator%2C len: 230 aa%3B similar to TR:O53612 (EMBL:AL021428) Mycobacterium tuberculosis transcriptional regulator (189 aa)%2C fasta scores%3B opt: 315 z-score: 346.2 E(): 5.8e-12%2C 35.5%25 identity in 172 aa overlap. Weak similarity to TR:O54180 (EMBL:AL021411)%2C SC7H1.22%2C S.coelicolor probable transcriptional regulator (203 aa) (34.4%25 identity in 154 aa overlap). Contains probable helix-turn-helix motif at aa 50-71 (Score 1594%2C +4.62 SD). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family (weak match) gene gene3337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3315 SCO3316 SCO3316 SCE68.14c SCE68.14c 3666980 3667756 - dehydrogenase SCE68.14c%2C probable dehydrogenase%2C len: 258 aa%3B similar to many e.g. SW:DHG3_BACME (EMBL:D10625)%2C gdhIII%2C Bacillus megaterium glucose 1-dehydrogenase III (261 aa)%2C fasta scores%3B opt: 424 z-score: 446.0 E(): 1.6e-17%2C32.4%25 identity in 253 aa overlap. Similar to many others from S.coelicolor e.g. TR:O88068 (EMBL:AL031541)%2C SCI35.33c%2C probable dehydrogenase (260 aa) (33.5%25 identity in 254 aa overlap). Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase and entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. Contains PS00061 Short-chain dehydrogenases/reductases family signature gene gene3338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3316 SCO3317 SCO3317 SCE68.15c SCE68.15c 3668023 3669720 - uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase SCE68.15c%2C possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase%2C len: 565 aa%3B similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503)%2C hemD%2C Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa)%2C fasta scores%3B opt: 519 z-score: 562.5 E(): 5.2e-24%2C 29.8%25 identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7%25 identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to entry PF00590 TP_methylase%2C Tetrapyrrole (Corrin/Porphyrin) Methylases and PS00839 Uroporphyrin-III C-methyltransferase signature 1 gene gene3339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3317 SCO3318 SCO3318 hemC hemC 3669717 3670676 - porphobilinogen deaminase transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis gene gene3340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3318 SCO3319 SCO3319 hemA hemA 3670673 3672418 - glutamyl-tRNA reductase catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH%3B the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid%3B functions in porphyrin (tetrapyrroles) biosynthesis%3B the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins gene gene3341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3319 SCO3320 SCO3320 SCE68.18c SCE68.18c 3672415 3673191 - redox-sensing transcriptional repressor Rex modulates transcription in response to the NADH/NAD(+) redox state gene gene3342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3320 SCO3321 SCO3321 SCE68.19c SCE68.19c 3673466 3673771 - redoxin SCE68.19c%2C possible redoxin%2C len: 101 aa%3B similar to TR:O69271 (EMBL:Y09572)%2C NrdH%2C Corynebacterium ammoniagenes NrdH-redoxin from a ribonucleotide reductase operon (75 aa)%2C fasta scores%3B opt: 96 z-score: 145.6 E(): 0.88%2C 27.6%25 identity in 76 aa overlap. Also similar to SW:YV35_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (97 aa) (33.3%25 identity in 75 aa overlap). Cys32 and Cys35 are conserved in similar proteins gene gene3343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3321 SCO3322 SCO3322 SCE68.20 SCE68.20 3673970 3674866 + hypothetical protein SCE68.20%2C membrane protein%2C len: 298 aa%3B unknown function%2C similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa)%2C fasta scores%3B opt: 463 z-score: 536.3 E(): 1.5e-22%2C 34.2%25 identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8%25 identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3%25 identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene3344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3322 SCO3323 SCO3323 SCE68.21 SCE68.21 3675442 3675975 + RNA polymerase sigma factor SCE68.21%2C probable RNA polymerase sigma factor%2C len: 177 aa%3B similar to many members of the extracytoplasmic function sigma factor family e.g. SW:CARQ_MYXXA (EMBL:X71062)%2C CarQ%2C Myxococcus xanthus RNA polymerase sigma factor (174 aa)%2C fasta scores%3B opt: 237 z-score: 281.3 E(): 2.4e-08%2C 32.0%25 identity in 169 aa overlap. Similar to others from S. coelicolor e.g. TR:O54163 (EMBL:AL021411)%2C SC7H1.04%2C possible sigma factor (200 aa) (30.8%25 identity in 172 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene3345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3323 SCO3324 SCO3324 SCE68.22 SCE68.22 3676214 3677473 + hypothetical protein SCE68.22%2C hypothetical protein%2C len: 419 aa%3B unknown function%2C probable serine-rich CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. An alternative start codon is present at codon 4 gene gene3346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3324 SCO3325 SCO3325 SCE68.23c SCE68.23c 3677515 3678582 - hypothetical protein SCE68.23c%2C conserved hypothetical protein%2C len: 355 aa%3B similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV29_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (358 aa)%2C fasta scores%3B opt: 1281 z-score: 1288.1 E(): 0%2C 56.5%25 identity in 356 aa overlap. Similar to TR:O54097 (EMBL:AL021529)%2C SC10A5.04%2C S.coelicolor hypothetical protein (295 aa) (64.4%25 identity in 278 aa overlap) gene gene3347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3325 SCO3326 SCO3326 SCE68.24c SCE68.24c 3678597 3679658 - epimerase SCE68.24c%2C possible epimerase%2C len: 353 aa%3B similar to many e.g. SW:GALE_SALT (EMBL:M33681)%2C galE%2C Salmonella typhimurium UDP-glucose 4-epimerase (337 aa)%2C fasta scores%3B opt: 209 z-score: 250.6 E(): 1.2e-06%2C 32.1%25 identity in 193 aa overlap. Similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV28_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis UDP-glucose 4-epimerase (376 aa) (45.0%25 identity in 353 aa overlap). N-terminal half weakly similar to the corresponding region of TR:O54156 (EMBL:AL021409)%2C SC3F7.13%2C S.coelicolor probable oxidoreductase (347 aa) (29.8%25 identity in 181 aa overlap) gene gene3348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3326 SCO3327 SCO3327 SCE68.25c SCE68.25c 3679848 3679946 - hypothetical protein SCE68.25c%2C hypothetical protein%2C len: 32 aa%3B unknown function%2C possible small%2C lysine-rich protein suggested by GC frameplot gene gene3349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3327 SCO3328 SCO3328 SCE68.26c SCE68.26c 3680056 3680268 - hypothetical protein SCE68.26c%2C hypothetical protein%2C len: 70 aa%3B similar to TR:Q49828 (EMBL:U00018) Mycobacterium leprae hypothetical protein (86 aa)%2C fasta scores%3B opt: 269 z-score: 380.5 E(): 7.2e-14%2C 68.3%25 identity in 63 aa overlap. Weakly similar to excisionases e.g. TR:Q54076 (EMBL:L11597)%2C xis%2C Saccharopolyspora erythraea excisionase (76 aa) (34.0%25 identity in 47 aa overlap) and SCE29.20c (EMBL:AL035707) S.coelicolor probable excisionase (66 aa) (33.3%25 identity in 48 aa overlap). Contains probable helix-turn-helix motif at aa 16-37 (Score 1251%2C +3.45 SD) gene gene3350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3328 SCO3329 SCO3329 SCE68.27c SCE68.27c 3680398 3681213 - hypothetical protein SCE68.27c%2C hypothetical protein%2C len: 271 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis%2C amino acid composition and possible RBS. The start codon is uncertain%2C alternatives being present at codons 19%2C 20 and 26 gene gene3351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3329 SCO3330 SCO3330 SCE68.28c SCE68.28c 3681507 3682610 - acetoin utilization protein SCE68.28c%2C probable acetoin utilization protein%2C len: 367 aa%3B similar to proteins known to be required for growth on acetoin and 2%2C3-butanediol in Bacillus subtilis and Staphylococcus xylosus e.g. SW:ACUC_BACSU (EMBL:L17309)%2C AcuC%2C Bacillus subtilis acetoin utilization protein (387 aa)%2C fasta scores%3B opt: 910 z-score: 1032.3 E(): 0%2C 43.5%25 identity in 315 aa overlap. Similar to many histone deacetylases e.g. SW:RPD3_YEAST (EMBL:S66438)%2C Rpd3%2C Saccharomyces cerevisiae histone deacetylases (433 aa) (32.0%25 identity in 338 aa overlap). Contains Pfam match to entry PF00850 Hist_deacetyl%2C Histone deacetylase family gene gene3352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3330 SCO3331 SCO3331 SCE68.29c SCE68.29c 3682630 3683877 - transmembrane transport protein SCE68.29c%2C possible transmembrane transport protein%2C len: 415 aa%3B similar to many e.g. TR:O30996 (EMBL:AF024666)%2C cmx%2C Corynebacterium striatum R-plasmid pTP10 transposon Tn5564 chloramphenicol export protein (391 aa)%2C fasta scores%3B opt: 215 z-score: 235.6 E(): 8.4e-06%2C 24.4%25 identity in 390 aa overlap. Similar to TR:O69867 (EMBL:AL023702)%2C SC1C3.25%2C S.coelicolor transmembrane transport protein (410 aa) (32.1%25 identity in 383 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene3353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3331 SCO3332 SCO3332 SCE68.30c SCE68.30c 3683901 3684617 - hypothetical protein SCE68.30c%2C possible membrane protein%2C len: 238 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains hydrophobic%2C possible membrane-spanning regions. Alternative start codons are present at codons 10 and 11. gene gene3354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3332 SCO3333 SCO3333 SCE68.31c SCE68.31c 3684694 3685341 - hydrolase SCE68.31c%2C possible hydrolase%2C len: 215 aa%3B similar to many e.g. TR:O68118 (EMBL:AF010496) Rhodobacter capsulatus hypothetical protein (225 aa)%2C fasta scores%3B opt: 456 z-score: 540.0 E(): 9.4e-23%2C 38.5%25 identity in 221 aa overlap. Weakly similar to SW:GPH_RHOCA (EMBL:U23145)%2C cbbZ%2C Rhodobacter capsulatus phosphoglycolate phosphatase (219 aa) (24.0%25 identity in 217 aa overlap). Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene3355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3333 SCO3334 SCO3334 SCE68.32 SCE68.32 3691374 3692384 + tryptophanyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene3359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3334 SCO3335 SCO3335 SCE7.02c SCE7.02c 3692339 3693343 - AraC family transcription regulator SCE7.02c%2C probable AraC-family transcriptional regulator%2C len: 334 aa%3B similar to many e.g. TR:CAB40696 (EMBL:AL049587) transcriptional regulator (325 aa) fasta scores%3B opt: 643%2C z-score: 750.6%2C E(): 0%2C (39.9%25 identity in 316 aa overlap) and TR:O30507 (EMBL:AF008308) from Pseudomonas aeruginosa (328 aa) fasta scores%3B opt: 360%2C z-score: 423.1%2C E(): 3e-16%2C (27.7%25 identity in 328 aa overlap). Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. Also contains probable helix-turn-helix motif (+4.06 SD) at 241-262aa. gene gene3360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3335 SCO3336 SCO3336 SCE7.03 SCE7.03 3693418 3693999 + hydrolase SCE7.03%2C possible hydrolase%2C len: 193aa%3B similar to many egs. TR:O07081 (EMBL:U93876) hypothetical protein from Bacillus subtilis (187 aa) fasta scores%3B opt: 370%2C z-score: 455.2%2C E(): 5e-18%2C (35.1%25 identity in 188 aa overlap) and SW:ENTB_ECOLI isochorismatase from Escherichia coli (285 aa) fasta scores%3B opt: 133%2C z-score: 168.5%2C E(): 0.046%2C (29.1%25 identity in 196 aa overlap). Contains Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family. gene gene3361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3336 SCO3337 SCO3337 proC proC 3694063 3694917 - pyrroline-5-carboxylate reductase SCE7.04c%2C proC%2C pyrroline-5-carboxylate reductase%2C len: 284aa%3B highly similar to many from prokaryotes and eukaryotes egs. SW:PROC_CORGL proC%2C pyrroline-5-carboxylate reductase from Corynebacterium glutamicum (270 aa) fasta scores%3B opt: 735%2C z-score: 832.5%2C E(): 0%2C (46.2%25 identity in 264 aa overlap) and SW:PROC_ARATH proC%2C pyrroline-5-carboxylate reductase from Arabidopsis thaliana (276 aa) fasta scores%3B opt: 604%2C z-score: 685.7%2C E(): 7.1e-31%2C (41.1%25 identity in 265 aa overlap). Contains Pfam match to entry PF01089 P5CR%2C Delta 1-pyrroline-5-carboxylate reductase and Prosite match to PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. gene gene3362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3337 SCO3338 SCO3338 SCE7.05c SCE7.05c 3695123 3695923 - hypothetical protein SCE7.05c%2C probable integral membrane protein%2C len: 266aa%3B similar to many hypothetical proteins eg. TR:O33188 (EMBL:Z98268) from Mycobacterium tuberculosis (226 aa) fasta scores%3B opt: 661%2C z-score: 725.6%2C E(): 4.3e-33%2C (45.1%25 identity in 226 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene3363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3338 SCO3339 SCO3339 SCE7.06c SCE7.06c 3695920 3696750 - ABC transporter ATP-binding protein SCE7.06c%2C probable ABC transporter ATP-binding subunit%2C len: 276aa%3B similar to many eg. TR:O33189 (EMBL:Z98268) ABC-type transport protein from Mycobacterium tuberculosis (255 aa) fasta scores%3B opt: 811%2C z-score: 850.0%2C E(): 0%2C (53.8%25 identity in 251 aa overlap) and TR:Q53626 (EMBL:U43537) ABC protein in mithramycin resistance (320 aa) fasta scores%3B opt: 491%2C z-score: 517.8%2C E(): 1.6e-21%2C (37.0%25 identity in 230 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3339 SCO3340 SCO3340 SCE7.07c SCE7.07c 3696891 3697673 - hypothetical protein SCE7.07c%2C unknown%2C len: 400 aa%3B similar to TR:O53392 (EMBL:AL021841) hypothetical protein from Mycobacterium tuberculosis (243 aa) fasta scores%3B opt: 424%2C z-score: 497.4%2C E(): 2.2e-20%2C (35.8%25 identity in 226 aa overlap). gene gene3365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3340 SCO3341 SCO3341 SCE7.08c SCE7.08c 3698670 3699173 - hypothetical protein SCE7.08c%2C possible integral membrane protein%2C len: 167aa%3B Contains possible membrane spanning hydrophobic regions. gene gene3366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3341 SCO3342 SCO3342 SCE7.09c SCE7.09c 3699215 3699889 - glycine-rich hypothetical protein SCE7.09c%2C possible glycine-rich hypothetical protein%2C len: 224aa%3B Contains a possible N-terminal signal sequence. Also contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene3367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3342 SCO3343 SCO3343 SCE7.10c SCE7.10c 3700056 3700430 - hypothetical protein SCE7.10c%2C unknown%2C len: 124 aa%3B similar to SW:YRAI_BACSU hypothetical protein from Bacillus subtilis (144 aa) fasta scores%3B opt: 252%2C z-score: 308.2%2C E(): 7.6e-10%2C (42.4%25 identity in 92 aa overlap). gene gene3368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3343 SCO3344 SCO3344 SCE7.11 SCE7.11 3700571 3702733 + Ser/Thr protein kinase SCE7.11%2C probable Ser/Thr protein kinase%2C len: 720 aa%3B similar to many from other Streptomyces spp. eg. SW:AFSK_STRCO Ser/Thr protein kinase from Streptomyces coelicolor (799 aa) fasta scores%3B opt: 896%2C z-score: 827.4%2C E(): 0%2C (33.1%25 identity in 771 aa overlap). Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and Prosite matches to PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature. Also contains five Pfam matches to entry PF01011 Bacterial_PQQ%2C PQQ enzyme repeat. gene gene3369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3344 SCO3345 SCO3345 SCE7.12c SCE7.12c 3702759 3704612 - dihydroxy-acid dehydratase catalyzes the dehydration of 2%2C3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis gene gene3370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3345 SCO3346 SCO3346 SCE7.13c SCE7.13c 3704768 3705382 - transcriptional regulator SCE7.13c%2C possible transcriptional regulator%2C len: 204 aa%3B similar to SW:UIDR_ECOLI uid operon repressor from Escherichia coli (196 aa) fasta scores%3B opt: 168%2C z-score: 207.0%2C E(): 0.00033%2C (28.7%25 identity in 188 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Note N-terminal region previously sequenced and annotated as a UDP-MurNAc L-alanine ligase-like protein therefore almost (conflict of two amino acids) identical to TR:O87451 (EMBL:AF068843) (63 aa) fasta scores%3B opt: 392%2C z-score: 473.9%2C E(): 4.5e-19%2C (96.8%25 identity in 63 aa overlap). gene gene3371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3346 SCO3347 SCO3347 SCE7.14c SCE7.14c 3705379 3706236 - hypothetical protein SCE7.14c%2C unknown%2C len: 285aa%3B similar to SW:YV24_MYCTU hypothetical protein from Mycobacterium tuberculosis (280 aa) fasta scores%3B opt: 569%2C z-score: 688.7%2C E(): 4.9e-31%2C (54.6%25 identity in 273 aa overlap) gene gene3372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3347 SCO3348 SCO3348 SCE7.15c SCE7.15c 3706398 3707327 - DNA-binding protein SCE7.15c%2C possible DNA-binding protein%2C len: 309 aa%3B similar to SW:YV22_MYCTU hypothetical protein from Mycobacterium tuberculosis (328 aa) fasta scores%3B opt: 991%2C z-score: 1143.8%2C E(): 0%2C (55.0%25 identity in 289 aa overlap) and similar to N-terminal region of SW:PPX_ECOLI (EMBL:L06129) Escherichia coli exopolyphosphatase Ppx%2C 512 aa%3B fasta scores: opt: 286 Z-score: 317.1 E(): 5e-10%3B 25.329%25 identity in 304 aa overlap. Contains possible helix-turn-helix motif (+3.03 SD) at 251..272 aa gene gene3373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3348 SCO3349 SCO3349 SCE7.16 SCE7.16 3707399 3708214 + hypothetical protein SCE7.16%2C unknown%2C len: 271aa%3B similar to SW:YV21_MYCTU hypothetical protein from Mycobacterium tuberculosis (296 aa) fasta scores%3B opt: 966%2C z-score: 1180.4%2C E(): 0%2C (50.4%25 identity in 278 aa overlap) gene gene3374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3349 SCO3350 SCO3350 SCE7.17c SCE7.17c 3708278 3710074 - hypothetical protein SCE94.01c%2C partial CDS unknown%2C alanine-rich protein%2C len: >503aa%3B~SCE7.17c%2C partial CDS%2C proline-rich protein%2C len: >129aa gene gene3375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3350 SCO3351 SCO3351 SCE94.02 SCE94.02 3710688 3712097 + DNA repair protein RadA Sms%3B stabilizes the strand-invasion intermediate during the DNA repair%3B involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents gene gene3376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3351 SCO3352 SCO3352 SCE94.03 SCE94.03 3712179 3713303 + DNA integrity scanning protein DisA non-specific DNA-binding%3B scans chromosomes during sporulation for DNA-damage%3B delays initiation of sporulation%3B participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair gene gene3377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3352 SCO3353 SCO3353 SCE94.04c SCE94.04c 3713340 3713720 - hypothetical protein SCE94.04c%2C unknown%2C len: 126aa gene gene3378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3353 SCO3354 SCO3354 SCE94.05 SCE94.05 3713731 3714135 + hypothetical protein SCE94.05%2C unknown%2C proline-rich%2C len: aa gene gene3379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3354 SCO3355 SCO3355 mutY mutY 3714378 3715304 + adenine glycosylase SCE94.06%2C mutY%2C adenine glycosylase%2C len: 308 aa%3B previously partially sequenced therefore partially identical to TR:E1358524 (EMBL:AJ131213) MutY%2C adenine glycosylase from Streptomyces coelicolor (183 aa) fasta scores%3B opt: 1220%2C z-score: 1357.4%2C E(): 0%2C (100.0%25 identity in 183 aa overlap). Also similar to many others e.g. SW:MUTY_SALTY MutY%2C adenine glycosylase from Salmonella typhimurium (350 aa) fasta scores%3B opt: 500%2C z-score: 558.7%2C E(): 8.3e-24%2C (39.4%25 identity in 231 aa overlap). Contains Pfam match to entry PF00730 Endonuclease_3%2C Endonuclease III. gene gene3380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3355 SCO3356 SCO3356 SCE94.07 SCE94.07 3715604 3716137 + ECF sigma factor SCE94.07%2C sigE%2C ECF sigma factor%2C len: 177 aa%3B previously sequenced therefore identical to TR:E1358525 (EMBL:AJ131213) SigE%2C ECF sigma factor from Streptomyces coelicolor (177 aa) fasta scores%3B opt: 1140%2C z-score: 1336.4%2C E(): 0%2C (100.0%25 identity in 177 aa overlap). Member of ECF sigma factors. Contains Prosite match to PS01063 Sigma-70 factors ECF subfamily signature. Also contains a possible helix-turn-helix region at 127-148aa (+3.34 SD). gene gene3381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3356 SCO3357 SCO3357 SCE94.08 SCE94.08 3716194 3716802 + hypothetical protein SCE94.08%2C unknown%2C len: 202aa%3B previously sequenced therefore identical to TR:e1358526 (EMBL:AJ131213) hypothetical protein from Streptomyces coelicolor (202 aa) fasta scores%3B opt: 1347%2C z-score: 1386.9%2C E(): 0%2C (99.5%25 identity in 202 aa overlap). Note conflict in first codon%2C GTG rather than ATG. gene gene3382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3357 SCO3358 SCO3358 cseB cseB 3716926 3717630 + two-component system response regulator SCE94.09%2C cseB%2C two-component system response regulator%2C len: 234 aa%3B previously sequenced therefore identical to TR:E1358527 (EMBL:AJ131213) CseB%2C response regulator%2C positive regulator of sigE transcription from Streptomyces coelicolor (234 aa) fasta scores%3B opt: 1529%2C z-score: 1731.2%2C E(): 0%2C (100.0%25 identity in 234 aa overlap). Also similar to many others eg. SW:PHOP_BACSU PhoP%2C response regulator of the phosphate regulon of Bacillus subtilis (240 aa) fasta scores%3B opt: 582%2C z-score: 665.4%2C E(): 9.4e-30%2C (41.2%25 identity in 233 aa overlap). Contains Pfam matches to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal and entry PF00072 response_reg%2C Response regulator receiver domain. gene gene3383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3358 SCO3359 SCO3359 SCE94.10 SCE94.10 3717647 3719170 + sensory histidine kinase contains hydrophobic membrane spanning regions SCE94.10%2C cseC%2C sensory histidine kinase%2C len: 507 aa%3B previously sequenced therefore identical to TR:E1358528 (EMBL:AJ131213) CseC%2C sensory histidine kinase from Streptomyces coelicolor (507 aa) fasta scores%3B opt: 3298%2C z-score: 3217.4%2C E(): 0%2C (100.0%25 identity in 507 aa overlap). Also similar to many others eg. SW:AFQ2_STRCO sensor protein%2C part of a two-component regulatory system involved in secondary metabolism in Streptomyces coelicolor (535 aa) fasta scores%3B opt: 382%2C z-score: 378.4%2C E(): 9.2e-14%2C (29.8%25 identity in 413 aa overlap). Contains Pfam matches to entry PF00672 DUF5%2C Domain found in bacterial signal proteins and entry PF00512 signal%2C Signal carboxyl-terminal domain. gene gene3384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3359 SCO3360 SCO3360 SCE94.11c SCE94.11c 3719200 3720033 - hypothetical protein SCE94.11c%2C unknown%2C len: 277aa%3B previously sequenced therefore identical to TR:E1358529 (EMBL:AJ131213) hypothetical protein from Streptomyces coelicolor (277 aa) fasta scores%3B opt: 1897%2C z-score: 2249.5%2C E(): 0%2C (99.6%25 identity in 277 aa overlap). gene gene3385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3360 SCO3361 SCO3361 SCE94.12c SCE94.12c 3720125 3720577 - transcription regulator AsnC SCE94.12c%2C lrpA%2C probable AsnC-family transcriptional regulator%2C len: 150a a%3B previously sequenced therefore identical to TR:E1358530 (EMBL:AJ131213) LrpA%2C transcriptional regulator from Streptomyces coelicolor (150 aa) fasta scores%3B opt: 953%2C z-score: 1220.9%2C E(): 0%2C (100.0%25 identity in 150 aa overlap). Also similar to many amino acid responsive regulators e.g. TR:O33467 (EMBL:D89015) MdeR%2C transcriptional regulator from Pseudomonas putida (159 aa) fasta scores%3B opt: 380%2C z-score: 494.5%2C E(): 3.1e-20%2C (40.0%25 identity in 150 aa overlap). Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family. Also contains a possible helix-turn-helix at 19-40aa (+4.10 SD). gene gene3386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3361 SCO3362 SCO3362 SCE94.13 SCE94.13 3720696 3721331 + hypothetical protein SCE94.13%2C membrane protein%2C len: 211 aa%3B weakly similar to many eg. SW:YRHP_BACSU hypothetical protein located close to sigma factor genes in Bacillus subtilis (210 aa) fasta scores%3B opt: 192%2C z-score: 222.0%2C E(): 4.7e-05%2C (25.0%25 identity in 164 aa overlap). Contains a possible membrane spanning hydrophobic regions gene gene3387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3362 SCO3363 SCO3363 SCE94.14 SCE94.14 3721342 3721785 + acetyltransferase SCE94.14%2C possible acetyltransferase%2C len: 147aa%3B weakly similar to many eg. SW:PAT_STRHY phosphinothricin acetyltransferase from Streptomyces hygroscopicus (183 aa) fasta scores%3B opt: 116%2C z-score: 157.5%2C E(): 0.19%2C (27.9%25 identity in 136 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene3388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3363 SCO3364 SCO3364 SCE94.15 SCE94.15 3721792 3722244 + hypothetical protein SCE94.15%2C unknown%2C len: 150aa gene gene3389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3364 SCO3365 SCO3365 SCE94.16c SCE94.16c 3722414 3723256 - hypothetical protein SCE94.16c%2C unknown%2C len: aa%3B similar to others from Streptomyces coelicolor eg. TR:E1370777 (EMBL:AL035212) possible DNA binding protein (303 aa) fasta scores%3B opt: 420%2C z-score: 512.3%2C E(): 3.2e-21%2C (32.5%25 identity in 265 aa overlap). gene gene3390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3365 SCO3366 SCO3366 SCE94.17c SCE94.17c 3723844 3725439 - exporter SCE94.17c%2C possible exporter%2C len: 531aa%3B similar to many export proteins eg. TR:G4240426 (EMBL:AF080235) antibiotic transporter landomycin biosynthesis cluster of Streptomyces cyanogenus S136 (517 aa) fasta scores%3B opt: 1848%2C z-score: 1973.8%2C E(): 0%2C (55.2%25 identity in 511 aa overlap). also similar to TR:E1370405 (EMBL:AL035161) efflux protein from Streptomyces coelicolor (815 aa) fasta scores%3B opt: 1622%2C z-score: 1730.4%2C E(): 0%2C (46.1%25 identity in 518 aa overlap). Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. Also contains several probable membrane spanning hydrophobic regions. gene gene3391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3366 SCO3367 SCO3367 SCE94.18 SCE94.18 3725598 3726185 + TetR family transcriptional regulator SCE94.18%2C possible tetR-family regulator%2C len: 195 aa%3B similar to many regulators e.g. TR:G4240425 (EMBL:AF080235) LanK from Streptomyces cyanogenus S136 (192 aa) fasta scores%3B opt: 584%2C z-score: 737.3%2C E(): 0%2C (51.4%25 identity in 185 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and Prosite match to PS01081 Bacterial regulatory proteins%2C tetR family signature. Also contains a probable helix-turn-helix at 43-55aa (+5.78 SD). gene gene3392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3367 SCO3368 SCO3368 SCE94.19c SCE94.19c 3726219 3726905 - peptidase SCE94.19c%2C possible peptidase (hypothetical protein)%2C len: 228 aa%3B similar to SW:ALE1_STACP glycylglycine endopeptidase from Staphylococcus capitis EPK1 (362 aa) fasta scores%3B opt: 329%2C z-score: 324.3%2C E(): 9.5e-11%2C (38.9%25 identity in 180 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene3393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3368 SCO3369 SCO3369 SCE94.20 SCE94.20 3727304 3729892 + large ATP-binding protein SCE94.20%2C possible large ATP-binding protein%2C len: 862aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Similar to two closely neighbouring genes SCE94.23 and SCE94.21 suggesting local duplication fasta scores%3B SCE94.23 opt: 1840%2C z-score: 1675.4%2C E(): 0%2C (48.9%25 identity in 839 aa overlap)%2C SCE94.21 opt: 789%2C z-score: 717.7%2C E(): 5e-35%2C (44.7%25 identity in 877 aa overlap). gene gene3394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3369 SCO3370 SCO3370 SCE94.21 SCE94.21 3729902 3732487 + large ATP-binding protein SCE94.21%2C possible large ATP-binding protein%2C len: 861 aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Similar to two closely neighbouring genes SCE94.23 and SCE94.20 suggesting local duplication%3B fasta scores: SCE94.23 opt: 984%2C z-score: 883.6%2C E(): 0%2C (43.6%25 identity in 857 aa overlap)%2C SCE94.20 opt: 789%2C z-score: 709.4%2C E(): 1.4e-34%2C (44.7%25 identity in 877 aa overlap) gene gene3395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3370 SCO3371 SCO3371 SCE94.22 SCE94.22 3732558 3733277 + hypothetical protein SCE94.22%2C unknown%2C len: 239aa gene gene3396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3371 SCO3372 SCO3372 SCE94.23 SCE94.23 3733321 3736353 + large ATP-binding protein SCE94.23%2C possible large ATP-binding protein%2C len: 1010aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Similar to two closely neighbouring genes SCE94.20 and SCE94.21 suggesting local duplication fasta scores%3B SCE94.20 opt: 1840%2C z-score: 1632.1%2C E(): 0%2C (48.9%25 identity in 839 aa overlap)%2C SCE94.21 opt: 984%2C z-score: 872.5%2C E(): 0%2C (43.8%25 identity in 857 aa overlap). gene gene3397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3372 SCO3373 SCO3373 SCE94.24c SCE94.24c 3736431 3738956 - Clp-family ATP-binding protease SCE94.24c%2C probable Clp-family ATP-binding protease%2C len: 841aa%3B highly similar to many egs. SW:MECB_BACSU MecB/ClpC pleiotropic regulator controlling competence gene expression and growth at high temperature in Bacillus subtilis (810 aa) fasta scores%3B opt: 3266%2C z-score: 3278.7%2C E(): 0%2C (61.6%25 identity in 805 aa overlap) and TR:Q48760 (EMBL:U40604) ClpC ATPase required for stress tolerance and in vivo survival of Listeria monocytogenes (825 aa) fasta scores%3B opt: 3204%2C z-score: 3216.3%2C E(): 0%2C (61.2%25 identity in 804 aa overlap). Also similar to TR:O69936 (EMBL:AL023861) clp protease ATP binding subunit from Streptomyces coelicolor (842 aa) fasta scores%3B opt: 2357%2C z-score: 2283.1%2C E(): 0%2C (48.9%25 identity in 829 aa overlap). Contains Pfam match to entry PF00495 clpA_B%2C Chaperonin clpA/B and two Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3373 SCO3374 SCO3374 SCE94.25 SCE94.25 3739398 3740099 + hypothetical protein SCE94.25%2C unknown%2C proline-rich%2C len: 702 aa gene gene3399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3374 SCO3375 SCO3375 SCE94.26c SCE94.26c 3740100 3740435 - Lsr2-like protein SCE94.26c%2C Lsr2-like protein%2C len: 111 aa%3B similar to SW:LSR2_MYCLE surface antigen protein from Mycobacterium tuberculosis (112 aa) fasta scores%3B opt: 358%2C z-score: 416.0%2C E(): 7.4e-16%2C (55.4%25 identity in 112 aa overlap). gene gene3400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3375 SCO3376 SCO3376 SCE94.27c SCE94.27c 3740711 3741220 - N-acetylglutamate synthase catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis gene gene3401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3376 SCO3377 SCO3377 SCE94.28c SCE94.28c 3741230 3741604 - hypothetical protein SCE94.28c%2C unknown%2C len: 124 aa%3B similar to hypothetical proteins eg. TR:O32909 (EMBL:AL008609) from Mycobacterium leprae (142 aa) fasta scores%3B opt: 215%2C z-score: 273.2%2C E(): 6.6e-08%2C (41.9%25 identity in 105 aa overlap). gene gene3402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3377 SCO3378 SCO3378 SCE94.29c SCE94.29c 3741763 3741942 - small membrane protein SCE94.29c%2C small membrane protein%2C len: 47 aa. Contains possible hydrophobic membrane spanning region gene gene3403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3378 SCO3379 SCO3379 SCE94.30c SCE94.30c 3741966 3742592 - hypothetical protein SCE94.30c%2C unknown%2C proline-rich%2C len: 208aa gene gene3404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3379 SCO3380 SCO3380 SCE94.31c SCE94.31c 3743026 3743823 - pantothenate kinase type III%3B catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis%3B type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP gene gene3405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3380 SCO3381 SCO3381 nadC nadC 3743829 3744818 - nicotinate-nucleotide pyrophosphorylase catalyzes the formation of pyridine-2%2C3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide gene gene3406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3381 SCO3382 SCO3382 nadB nadB 3744824 3746566 - L-aspartate oxidase catalyzes the formation of oxaloacetate from L-aspartate gene gene3407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3382 SCO3383 SCO3383 panC panC 3746563 3747576 - pantoate--beta-alanine ligase catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine gene gene3408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3383 SCO3384 SCO3384 SCE126.02c SCE126.02c 3747573 3748835 - hypothetical protein SCE126.02c%2C unknown%2C len: 420aa%3B similar to TR:O06279 (EMBL:Z95557) hypothetical protein from Mycobacterium tuberculosis (303 aa) fasta scores%3B opt: 683%2C z-score: 584.3%2C E(): 3.1e-25%2C (49.3%25 identity in 284 aa overlap). gene gene3409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3384 SCO3385 SCO3385 SCE126.03 SCE126.03 3749036 3750247 + L-allo-threonine aldolase SCE126.03%2C possible lyase%2C len: 403aa%3B weakly similar to many eg. SW:LTAA_AERJA L-allo-threonine aldolase from Aeromonas jandaei DK-39 (338 aa) fasta scores%3B opt: 257%2C z-score: 293.4%2C E(): 5e-09%2C (31.4%25 identity in 255 aa overlap). gene gene3410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3385 SCO3386 SCO3386 SCE126.04 SCE126.04 3750419 3750691 + hypothetical protein SCE126.04%2C unknown%2C len: 90aa gene gene3411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3386 SCO3387 SCO3387 SCE126.05 SCE126.05 3750688 3751794 + transcriptional regulator SCE126.05%2C possible transcriptional regulator%2C len: 368aa%3B similar to many in a limited region which corresponds to the probable DNA-binding site eg. SW:SMTB_SYNP7 SmtB transcriptional repressor from Synechococcus sp. (Strain PCC7942) (122 aa) fasta scores%3B opt: 169%2C z-score: 204.8%2C E(): 0.00043%2C (37.0%25 identity in 92 aa overlap). Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene3412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3387 SCO3388 SCO3388 SCE126.06c SCE126.06c 3751837 3752478 - TmrB-like protein SCE126.06c%2C TmrB-like protein%2C len: 213aa%3B similar to SW:TMRB_BACSU tunicamycin resistance protein (binds tunicamycin) from Bacillus subtilis (197 aa) fasta scores%3B opt: 335%2C z-score: 416.0%2C E(): 7.3e-16%2C (38.9%25 identity in 203 aa overlap). gene gene3413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3388 SCO3389 SCO3389 SCE126.07c SCE126.07c 3752539 3753213 - two component system response regulator SCE126.07c%2C probable two component system response regulator%2C len: 224aa%3B similar to many%2C particularly others from Streptomyces coelicolor eg. TR:O86632 (EMBL:AL031155) two component regulator (222 aa) fasta scores%3B opt: 784%2C z-score: 897.1%2C E(): 0%2C (57.7%25 identity in 215 aa overlap). Also similar to SW:DEGU_BACSU transcriptional regulator protein DegU from Bacillus subtilis (229 aa) fasta scores%3B opt: 466%2C z-score: 538.0%2C E(): 1.2e-22%2C (37.2%25 identity in 223 aa overlap). Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain and to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Also contains Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature. gene gene3414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3389 SCO3390 SCO3390 SCE126.08c SCE126.08c 3753279 3754484 - two component sensor kinase SCE126.08c%2C possible two component sensor kinase%2C len: 401 aa%3B similar to many%2C often from Streptomyces coelicolor e.g. TR:O88024 (EMBL:AL031107) two component sensor (405 aa) fasta scores%3B opt: 718%2C z-score: 796.4%2C E(): 0%2C (42.2%25 identity in 313 aa overlap). Also similar to SW:DEGS_BACBR sensor protein DegS from Bacillus brevis (386 aa) fasta scores%3B opt: 320%2C z-score: 358.3%2C E(): 1.2e-12%2C (30.1%25 identity in 236 aa overlap). N-terminal half contains possible membrane spanning hydrophobic regions followed by a possible coiled-coil at approx. aa 180 gene gene3415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3390 SCO3391 SCO3391 SCE126.09 SCE126.09 3754603 3755691 + hypothetical protein SCE126.09%2C unknown%2Clen: 362aa%3B similar to TR:O25492 (EMBL:AE000593) hypothetical protein from Helicobacter pylori (336 aa) fasta scores%3B opt: 143%2C z-score: 161.4%2C E(): 0.11%2C (31.5%25 identity in 111 aa overlap). gene gene3416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3391 SCO3392 SCO3392 nuoD2 nuoD2 3755656 3756807 - NADH dehydrogenase subunit NuoD2 SCE126.10%2C nuoD2%2C probable NADH dehydrogenase subunit%2C len: 383 aa%3B similar to many others e.g. SW:NUOD_ECOLI NADH dehydrogenase chain D (407 aa) fasta scores%3B opt: 689%2C z-score: 821.3%2C E(): 0%2C (33.2%25 identity in 397 aa overlap). Contains two Pfam matches to entry PF00346 complex1_49Kd%2C Respiratory-chain NADH dehydrogenase%2C 49 Kd subunit and Prosite match to PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. gene gene3417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3392 SCO3393 SCO3393 SCE126.11 SCE126.11 3756941 3757396 + hypothetical protein SCE126.11%2C possible integral membrane protein%2C len: 151aa%3B similar to other hypotheticals eg. TR:P96615 (EMBL:AB001488) hypothetical protein from Bacillus subtilis (159 aa) fasta scores%3B opt: 208%2C z-score: 264.3%2C E(): 2.1e-07%2C (30.3%25 identity in 145 aa overlap). Contains a possible membrane spanning hydrophobic region. gene gene3418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3393 SCO3394 SCO3394 SCE126.12 SCE126.12 3757393 3759117 + hypothetical protein SCE9.01%2C hypothetical protein%2C partial CDS%2C len: >436 aa%3B unknown function%2C this is the remainder of CDS SCE126.12 (EMBL:AL049630). Weakly similar to TR:O33222 (EMBL:Z98260) Mycobacterium tuberculosis hypothetical protein (487 aa)%2C fasta scores%3B opt: 203 z-score: 237.4 E(): 6.7e-06%2C 30.3%25 identity in 347 aa overlap. Contains hydrophobic membrane spanning region and contains probable coiled-coil from 394 to 429 (36 residues) (Max score: 1.471%2C probability 0.91)~SCE126.12%2C partial CDS%2C unknown%2C proline-rich%2C len: >174aa gene gene3419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3394 SCO3395 SCO3395 SCE9.02c SCE9.02c 3759147 3760322 - hypothetical protein SCE9.02c%2C hypothetical protein%2C len: 391 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Hydrophobic region at N-terminus and degenerate E(T/A)(P/R)EQ repeat in centre. Contains probable coiled-coil from 45 to 114 (70 residues) (Max score: 1.834%2C probability 1.00). Contains possible N-terminal region signal peptide sequence gene gene3420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3395 SCO3396 SCO3396 SCE9.03c SCE9.03c 3760573 3761706 - hypothetical protein SCE9.03c%2C possible membrane protein%2C len: 370 aa%3B unknown function%2C similar to SW:YLI2_CORGL (EMBL:X60312) Corynebacterium glutamicum hypothetical protein (426 aa)%2C fasta scores%3B opt: 274 z-score: 307.1 E(): 8.8e-10%2C 23.9%25 identity in 351 aa overlap and TR:P94973 (EMBL:Z85982) Mycobacterium tuberculosis hypothetical protein (489 aa) (23.1%25 identity in 386 aa overlap). Contains hydrophobic regions at N-terminus%2C possibly a membrane anchor gene gene3421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3396 SCO3397 SCO3397 SCE9.04 SCE9.04 3761869 3763674 + integral membrane lysyl-tRNA synthetase SCE9.04%2C possible integral membrane lysyl-tRNA synthetase%2C len: 601 aa%3B unknown function%2C similar to hypothetical proteins e.g. N-terminal half of SW:P94974 (SYK2_MYCTU) Mycobacterium tuberculosis probable lysyl-tRNA synthetase (1172 aa)%2C fasta scores%3B opt: 1245 z-score: 1445.4 E(): 0%2C 39.9%25 identity in 604 aa overlap and TR:O69916 (EMBL:AL023861) S.coelicolor integral membrane protein (589 aa) (45.8%25 identity in 539 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene3422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3397 SCO3398 SCO3398 folP folP 3764143 3765009 + dihydropteroate synthase SCE9.05%2C folP%2C probable dihydropteroate synthase%2C len: 288 aa%3B similar to many e.g. SW:DHPS_ECOLI (EMBL:X68776)%2C FolP%2C Escherichia coli dihydropteroate synthase (282 aa)%2C fasta scores%3B opt: 618 z-score: 694.3 E(): 2.4e-31%2C 39.9%25 identity in 268 aa overlap. Contains Pfam match to entry PF00809 DHPS%2C Dihydropteroate synthase%2C score 418.00%2C E-value 8.9e-122%2C PS00792 Dihydropteroate synthase signature 1 and PS00793 Dihydropteroate synthase signature 2 gene gene3423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3398 SCO3399 SCO3399 SCE9.06 SCE9.06 3765006 3765509 + hypothetical protein SCE9.06%2C hypothetical protein%2C len: 167 aa%3B probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3399 SCO3400 SCO3400 folB folB 3765814 3766173 + dihydroneopterin aldolase SCE9.07%2C folB%2C probable dihydroneopterin aldolase%2C len: 119 aa%3B similar to many e.g. the N-terminal%2C dihydroneopterin aldolase domain of SW:SULD_STRPN (EMBL:U16156)%2C sulD%2C Streptococcus pneumoniae bifunctional dihydroneopterin aldolase/hydroxymethyldihydropterin pyrophosphokinase (270 aa)%2C fasta scores%3B opt: 240 z-score: 310.8 E(): 5.5e-10%2C 31.9%25 identity in 119 aa overlap. start codon suggested by GC frame plot and the presence of a potential RBS gene gene3425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3400 SCO3401 SCO3401 folK folK 3766170 3766781 + 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase SCE9.08%2C folK%2C probable hydroxymethyldihydropteridine pyrophosphokinase%2C len: 203 aa%3B similar to many e.g. SW:HPPK_ECOLI (EMBL:L06495)%2C FolK%2C Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (158 aa)%2C fasta scores%3B opt: 351 z-score: 426.9 E(): 1.9e-16%2C 42.0%25 identity in 138 aa overlap. start codon suggested by GC frame plot and the presence of a potential RBS%2C resulting in a short N-terminal extension not present in homologs. There is an alternative start codon at position 17. Contains Pfam match to entry PF01288 HPPK%2C 7%2C8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)%2C score 145.80%2C E-value 7.5e-40 gene gene3426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3401 SCO3402 SCO3402 SCE9.09 SCE9.09 3766852 3767340 + hypothetical protein SCE9.09%2C possible hypothetical protein%2C len: 162 aa%3B unknown function%2C similar to TR:O06277 (EMBL:Z95557) Mycobacterium tuberculosis hypothetical protein (158 aa)%2C fasta scores%3B opt: 174 z-score: 218.1 E(): 7.9e-05%2C 31.3%25 identity in 128 aa overlap. Hydrophobic protein containing possible N-terminal signal sequence gene gene3427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3402 SCO3403 SCO3403 folE folE 3767356 3767961 - GTP cyclohydrolase I involved in the first step of tetrahydrofolate biosynthesis%3B catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1%2C2%2C3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water%3B forms a homopolymer gene gene3428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3403 SCO3404 SCO3404 ftsH2 ftsH2 3768093 3770099 - cell division protein FtsH-like protein SCE9.11c%2C ftsH2%2C cell division protein ftsH homolog%2C len: 668 aa%3B similar to many e.g. SW:FTSH_ECOLI (EMBL:M83138)%2C ftsH%2C Escherichia coli membrane-bound%2C ATP-dependent protease involved in cell cycle control (644 aa)%2C fasta scores%3B opt: 1921 z-score: 1987.4 E(): 0%2C 48.5%25 identity in 641 aa overlap. Similar to TR:O69875 (EMBL:AL023797)%2C ftsH%2C S.coelicolor cell division protein ftsH homolog (648 aa) (43.3%25 identity in 610 aa overlap)%2C but lacking the proline-rich N-terminus. Contains a hydrophobic%2C possible membrane-spanning region near the N-terminus. Contains Pfam match to entry PF00004 AAA%2C ATPases associated with various cellular activities (AAA)%2C score 335.00%2C E-value 8.4e-97%2C PS00674 AAA-protein family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3404 SCO3405 SCO3405 hprT hprT 3770329 3770892 - hypoxanthine phosphoribosyltransferase SCE9.12c%2C hprT%2C probable hypoxanthine phosphoribosyltransferase%2C len: 187 aa%3B similar to many e.g. TR:O33799 (EMBL:AF008931)%2C HprT%2C Salmonella typhimurium hypoxanthine phosphoribosyltransferase (178 aa)%2C fasta scores%3B opt: 583 z-score: 711.2 E(): 2.7e-32%2C 54.2%25 identity in 166 aa overlap. The start codon is uncertain as there are 5 potential. Contains Pfam match to entry PF00156 Pribosyltran%2C Purine/pyrimidine phosphoribosyl transferases%2C score 177.70%2C E-value 1.9e-49 and PS00103 Purine/pyrimidine phosphoribosyl transferases signature. Contains probable coiled-coil from 3 to 39 (37 residues) (Max score: 1.481%2C probability 0.93) gene gene3430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3405 SCO3406 SCO3406 SCE9.13c SCE9.13c 3770964 3772022 - hypothetical protein SCE9.13c%2C conserved hypothetical protein%2C len: 352 aa%3B similar to many e.g. SW:MESJ_ECOLI (EMBL:D49445)%2C mesJ%2C Escherichia coli cell cycle protein (432 aa)%2C fasta scores%3B opt: 327 z-score: 356.8 E(): 1.5e-12%2C 34.4%25 identity in 282 aa overlap. Highly similar to SW:YZC5_MYCTU (EMBL:Z95436) Mycobacterium tuberculosis hypothetical protein (323 aa) (47.9%25 identity in 305 aa overlap) gene gene3431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3406 SCO3407 SCO3407 SCE9.14c SCE9.14c 3772215 3773342 - hypothetical protein SCE9.14c%2C conserved hypothetical protein%2C len: 375 aa%3B unknown function%2C highly similar to TR:O06381 (EMBL:Z95436) Mycobacterium tuberculosis hypothetical protein (350 aa)%2C fasta scores%3B opt: 720 z-score: 820.9 E(): 0%2C 41.6%25 identity in 361 aa overlap and similar to TR:O53341 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical protein (472 aa) (25.6%25 identity in 383 aa overlap) and TR:Q49746 (EMBL:U00016) Mycobacterium leprae hypothetical protein (479 aa) (24.9%25 identity in 305 aa overlap) gene gene3432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3407 SCO3408 SCO3408 SCE9.15c SCE9.15c 3773464 3774843 - hypothetical protein SCE9.15c%2C possible penicillin-binding protein%2C len: 459 aa%3B weakly similar to penicillin-binding proteins e.g. SW:DAC_ACTSP (EMBL:X64790)%2C dac%2C Actinomadura sp. D-alanyl-D-alanine carboxypeptidase precursor (538 aa)%2C fasta scores%3B opt: 248 z-score: 243.2 E(): 3.2e-06%2C 29.5%25 identity in 499 aa overlap and TR:O85665 (EMBL:AF071224)%2C pbp3%2C Neisseria gonorrhoeae penicillin binding protein 3 (469 aa) (26.8%25 identity in 399 aa overlap). Similar to SC9B2.18c (EMBL:AL035212) S.coelicolor probable carboxypeptidase (451 aa) (36.1%25 identity in 429 aa overlap). The start codon is uncertain as there are 2 potential gene gene3433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3408 SCO3409 SCO3409 ppa ppa 3775145 3775636 + inorganic pyrophosphatase SCE9.16%2C ppa%2C probable inorganic pyrophosphatase%2C len: 163 aa%3B similar to many e.g. SW:IPYR_SULAC (EMBL:X81842)%2C ppa%2C Sulfolobus acidocaldarius inorganic pyrophosphatase (173 aa)%2C fasta scores%3B opt: 483 z-score: 617.4 E(): 4.6e-27%2C 46.4%25 identity in 166 aa overlap. Contains Pfam match to entry PF00719 Pyrophosphatase%2C Inorganic pyrophosphatase%2C score 163.70%2C E-value 3e-45 and PS00387 Inorganic pyrophosphatase signature gene gene3434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3409 SCO3410 SCO3410 SCE9.17 SCE9.17 3775723 3777459 + hypothetical protein SCE9.17%2C possible membrane protein%2C len: 578 aa%3B similar to TR:O69704 (EMBL:AL022121) Mycobacterium tuberculosis membrane protein (529 aa)%2C fasta scores%3B opt: 642 z-score: 677.3 E(): 2.1e-30%2C 31.6%25 identity in 481 aa overlap. The start codon is uncertain as there are 2 potential. The general position of the CDS start was estimated by GC frame plot. Contains hydrophobic%2C possible membrane-spanning regions in the C-terminal half%2C while the N-terminal half is more hydrophilic gene gene3435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3410 SCO3411 SCO3411 SCE9.18c SCE9.18c 3777456 3778367 - hypothetical protein SCE9.18c%2C possible membrane protein%2C len: 303 aa%3B similar to many hypothetical proteins e.g. SW:DEDA_ECOLI (EMBL:M68934)%2C dedA%2C Escherichia coli hypothetical protein in hisT-purF region (219 aa)%2C fasta scores%3B opt: 588 z-score: 585.6 E(): 2.7e-25%2C 49.7%25 identity in 187 aa overlap. Similar to others from S.coelicolor e.g. TR:O86627 (EMBL:AL031155) DedA family hypothetical protein (228 aa) (41.4%25 identity in 203 aa overlap). Central region contains hydrophobic%2C possible membrane spans and C-terminal region contains glutamine-rich repeats. Contains Pfam match to entry PF00597 DedA%2C DedA family%2C score 104.00%2C E-value 2.9e-27 gene gene3436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3411 SCO3412 SCO3412 SCE9.19 SCE9.19 3778548 3778868 + hypothetical protein SCE9.19%2C conserved hypothetical protein%2C len: 106 aa%3B unknown function%2C weakly similar to e.g. TR:O26644 (EMBL:AE000837) Methanobacterium thermoautotrophicum hypothetical protein (127 aa)%2C fasta scores%3B opt: 338 z-score: 369.7 E(): 2.9e-13%2C 50.5%25 identity in 107 aa overlap gene gene3437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3412 SCO3413 SCO3413 SCE9.20 SCE9.20 3778914 3779675 - transcriptional regulator SCE9.20c%2C tipA%2C transcriptional regulator%2C len: 253 aa%3B highly similar to many e.g. SW:TIPA_STRLI (EMBL:S64314)%2C TipA%2C Streptomyces lividans thiostrepton-binding transcriptional activator (253 aa)%2C fasta scores%3B opt: 1693 z-score: 1909.7 E(): 0%2C 99.6%25 identity in 253 aa overlap. Weakly similar to others from S. coelicolor e.g. TR:O54191 (EMBL:AL021411) probable transcriptional regulator (196 aa) (29.8%25 identity in 181 aa overlap). Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family%2C score 66.50%2C E-value 5.7e-1 and PS00552 Bacterial regulatory proteins%2C merR family signature. Contains probable coiled-coil from 77 to 107 (31 residues) (Max score: 1.523%2C probability 0.97) gene gene3438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3413 SCO3414 SCO3414 SCE9.21c SCE9.21c 3779785 3780231 - transcriptional regulator SCE9.21c%2C possible transcriptional regulator%2C len: 148 aa%3B weakly similar to TR:P71885 (EMBL:Z79702) Mycobacterium tuberculosis hypothetical protein (163 aa)%2C fasta scores%3B opt: 166 z-score: 220.3 E(): 6e-05%2C 29.5%25 identity in 139 aa overlap and TR:O34949 (EMBL:AJ002571)%2C ykoM%2C Bacillus subtilis hypothetical protein (154 aa) (27.0%25 identity in 141 aa overlap). Contains Pfam match to entry PF01047 MarR%2C MarR family%2C score 71.50%2C E-value 1.8e-17 gene gene3439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3414 SCO3415 SCO3415 SCE9.22 SCE9.22 3780468 3781268 + esterase SCE9.22%2C probable esterase%2C len: 266 aa%3B similar to many e.g. SW:BAH_STRHY (EMBL:M64783)%2C bah%2C Streptomyces hygroscopicus acetyl-hydrolase in bialaphos biosynthetic gene cluster (299 aa)%2C fasta scores%3B opt: 637 z-score: 678.5 E(): 1.8e-30%2C 45.3%25 identity in 236 aa overlap. Contains PS01173 Lipolytic enzymes 'G-D-X-G' family%2C histidine active site gene gene3440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3415 SCO3416 SCO3416 gad gad 3781328 3782755 + glutamate decarboxylase SCE9.23%2C gad%2C probable glutamate decarboxylase%2C len: 475 aa%3B similar to many e.g. SW:DCEA_ECOLI (EMBL:M84024)%2C gadA%2C Escherichia coli glutamate decarboxylase alpha (466 aa)%2C fasta scores%3B opt: 1433 z-score: 1665.2 E(): 0%2C 50.0%25 identity in 426 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC%2C Pyridoxal-dependent decarboxylase conserved domain%2C score 276.70%2C E-value 1.1e-79 gene gene3441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3416 SCO3417 SCO3417 SCE9.24c SCE9.24c 3782903 3783685 - ABC transporter SCE9.24c%2C probable ABC transporter transmembrane component%2C len: 315 aa%3B similar to many e.g. SW:DRRB_STRPE (EMBL:M73758)%2C drrB%2C Streptomyces peucetius daunorubicin resistance transmembrane protein (283 aa)%2C fasta scores%3B opt: 507 z-score: 565.3 E(): 3.6e-24%2C 35.6%25 identity in 264 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene3442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3417 SCO3418 SCO3418 SCE9.25c SCE9.25c 3783682 3784629 - ABC transporter ATP-binding protein SCE9.25c%2C probable ABC transporter ATP-binding component%2C len: 315 aa%3B similar to many e.g SW:DRRA_STRPE (EMBL:M73758)%2C drrA%2C Streptomyces peucetius daunorubicin resistance ATP-binding protein (330 aa)%2C fasta scores%3B opt: 942 z-score: 1020.6 E(): 0%2C 51.4%25 identity in 317 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C score 187.90%2C E-value 1.6e-52%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3418 SCO3419 SCO3419 SCE9.26c SCE9.26c 3784717 3785358 - hypothetical protein SCE9.26c%2C hypothetical protein%2C len: 213 aa%3B unknown function%2C weakly similar to TR:P7170 (EMBL:Z80775) Mycobacterium tuberculosis hypothetical protein (180 aa)%2C fasta scores%3B opt: 154 z-score: 195.5 E(): 0.0014%2C 27.0%25 identity in 178 aa overlap. The start codon is uncertain as there are 2 potential gene gene3444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3419 SCO3420 SCO3420 SCE9.27c SCE9.27c 3785441 3786901 - aldehyde dehydrogenase SCE9.27c%2C probable aldehyde dehydrogenase%2C len: 486 aa%3B highly similar to many NAD-linked aldehyde dehydrogenases e.g. SW:XYLC_PSEPU (EMBL:U15151)%2C xylC%2C Pseudomonas putida benzaldehyde dehydrogenase [NAD+] from TOL plasmid pWW0 (487 aa)%2C fasta scores%3B opt: 1244 z-score: 1420.3 E(): 0%2C 41.5%25 identity in 479 aa overlap. Similar to others from S.coelicolor e.g. TR:O88069 (EMBL:AL031541) probable aldehyde dehydrogenase (483 aa) (40.0%25 identity in 448 aa overlap). Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase%2C score 491.30%2C E-value 7.6e-144%2C PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site gene gene3445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3420 SCO3421 SCO3421 SCE9.28c SCE9.28c 3786977 3787801 - hypothetical protein SCE9.28c%2C hypothetical protein%2C len: 274 aa%3B similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515)%2C SC5C7.22C%2C hypothetical protein (287 aa)%2C fasta scores%3B opt: 727 z-score: 871.9 E(): 0%2C 44.7%25 identity in 273 aa overlap gene gene3446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3421 SCO3422 SCO3422 SCE9.29c SCE9.29c 3787911 3788114 - hypothetical protein SCE9.29c%2C hypothetical protein%2C len: 67 aa%3B improbable CDS suggested by GC frame plot alone gene gene3447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3422 SCO3423 SCO3423 SCE9.30 SCE9.30 3788179 3788643 + regulator SCE9.30%2C possible regulator%2C len: 154 aa%3B similar to TR:Q53897 (EMBL:X60316)%2C AbaA%2C Streptomyces coelicolor ORFA from AbaA regulatory locus for antibiotic production (192 aa)%2C fasta scores%3B opt: 278 z-score: 352.7 E(): 2.5e-12%2C 39.9%25 identity in 148 aa overlap. Also similar to several S. coelicolor hypothetical proteins including the N-terminus of TR:O86807 (EMBL:AL031031)%2C SC7C7.02c%2C possible regulatory protein (916 aa) (35.0%25 identity in 137 aa overlap). Contains TTA (leucine) codon%2C possible target for bldA regulation%2C near N-terminus gene gene3448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3423 SCO3424 SCO3424 SCE9.31c SCE9.31c 3788692 3788943 - regulator SCE9.31c%2C possible regulator%2C len: 83 aa%3B similar to TR:Q53896 (EMBL:X60316)%2C abaA%2C Streptomyces coelicolor ORFD from AbaA regulatory locus for antibiotic production (75 aa)%2C fasta scores%3B opt: 307 z-score: 422.3 E(): 3.4e-16%2C 64.9%25 identity in 74 aa overlap and to TR:Q53842 (EMBL:U28930)%2C BldB%2C S.coelicolor developmental protein (98 aa) (41.8%25 identity in 67 aa overlap) gene gene3449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3424 SCO3425 SCO3425 rpsR2 rpsR2 3789248 3789487 - 30S ribosomal protein S18 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%3B helps stabilize the platform of the 30S subunit gene gene3450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3425 SCO3426 SCO3426 SCE9.33c SCE9.33c 3789569 3790681 - hypothetical protein SCE9.33c%2C conserved hypothetical protein%2C len: 370 aa%3B similar to hypothetical proteins in Burkholderia%2C Mycobacterium tuberculosis and Bacillus subtilis. Similar to SW:P47K_PSECL (EMBL:D90216) Pseudomonas chlororaphis 47 kD protein critical for the expression of nitrile hydratase genes (419 aa)%2C fasta scores%3B opt: 374 z-score: 409.4 E(): 1.8e-15%2C 28.1%25 identity in 392 aa overlap gene gene3451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3426 SCO3427 SCO3427 rpmE2 rpmE2 3790678 3790932 - 50S ribosomal protein L31 RpmE2%3B there appears to be two types of ribosomal proteins L31 in bacterial genomes%3B some contain a CxxC motif while others do not%3B Bacillus subtilis has both types%3B the proteins in this cluster do not have the CXXC motif%3B RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth%3B expression of ytiA is controlled by a zinc-specific transcriptional repressor%3B RpmE contains one zinc ion and a CxxC motif is responsible for this binding%3B forms an RNP particle along with proteins L5%2C L18%2C and L25 and 5S rRNA%3B found crosslinked to L2 and L25 and EF-G%3B may be near the peptidyltransferase site of the 50S ribosome gene gene3452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3427 SCO3428 SCO3428 rpmG rpmG 3790939 3791103 - 50S ribosomal protein L33 in Escherichia coli BM108%2C a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function%3B there are paralogous genes in several bacterial genomes%2C and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31%3B the proteins in this group lack the CXXC motif gene gene3453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3428 SCO3429 SCO3429 rpmB rpmB 3791176 3791412 + 50S ribosomal protein L28 required for 70S ribosome assembly gene gene3454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3429 SCO3430 SCO3430 rpsN rpsN 3791412 3791717 + 30S ribosomal protein S14 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit%3B similar to what is observed with proteins L31 and L33%2C some proteins in this family contain CXXC motifs that are involved in zinc binding%3B if two copies are present in a genome%2C then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc%3B the proteins in this group do not appear to have the zinc-binding motif gene gene3455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3430 SCO3431 SCO3431 SCE9.38 SCE9.38 3791719 3792453 + hypothetical protein SCE9.38%2C possible membrane protein%2C len: 244 aa%3B unknown function%2C contains a hydrophobic%2C possible membrane-spanning region. Contains PS00213 Lipocalin signature%2C so may be involved in transport of small%2C hydrophobic molecules gene gene3456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3431 SCO3432 SCO3432 SCE9.39c SCE9.39c 3792412 3793668 - hypothetical protein SCE9.39c%2C hypothetical protein%2C len: 418 aa%3B unknown function%2C C-terminal end similar to TR:O07428 (EMBL:Z97050) Mycobacterium tuberculosis hypothetical protein (249 aa)%2C fasta scores%3B opt: 231 z-score: 252.5 E(): 9.7e-07%2C 30.4%25 identity in 270 aa overlap. Contains probable coiled-coil from 254 to 283 (30 residues) (Max score: 1.418%2C probability 0.78) gene gene3457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3432 SCO3433 SCO3433 SCE9.40 SCE9.40 3793755 3794531 + hypothetical protein SCE9.40%2C conserved hypothetical protein%2C len: 258 aa%3B unknown function%2C C-terminus similar to N-terminal region of the clpC family of ATP-dependent Clp protease ATP-binding subunits e.g. TR:Q48760 (EMBL:U40604)%2C mec%2C Listeria monocytogenes clpC ATPase (825 aa)%2C fasta scores%3B opt: 272 z-score: 311.0 E(): 5.3e-10%2C 36.4%25 identity in 140 aa overlap. A hypothetical protein of similar length occurs in Mycobacterium tuberculosis%3B TR:P71964 (EMBL:Z80225) clpC family hypothetical protein (252 aa) (57.3%25 identity in 255 aa overlap). Contains probable helix-turn-helix motif at aa 62-83 (Score 1144%2C +3.08 SD) gene gene3458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3433 SCO3434 SCO3434 SCE36.01 SCE36.01 3794733 3796424 + DNA polymerase I SCE36.01%2C partial CDS%2C possible DNA polymerase I%2C len: >328 aa%3B similar to the C-terminal region many e.g. SW:DPO1_CHLAU DNA polymerase I from Chloroflexus aurantiacus (942 aa) fasta scores%3B opt: 287%2C z-score: 322.2%2C E(): 1.3e-10%2C (28.9%25 identity in 305 aa overlap). Contains two Pfam matches to entry PF00476 DNA_pol_A%2C DNA polymerase family A.~SCE9.41%2C hypothetical protein%2C partial CDS%2C len: >268 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3434 SCO3435 SCO3435 SCE36.02 SCE36.02 3796515 3797402 + transcriptional regulator SCE36.02%2C probable transcriptional regulator%2C len: 295 aa%3B similar to many e.g. SW:GLTC_BACSU glutamate biosynthesis transcriptional regulator from Bacillus subtilis (300 aa) fasta scores%3B opt: 456%2C z-score: 520.3%2C E(): 1.2e-21%2C (31.9%25 identity in 288 aa overlap). Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix proteins%2C lysR family and Prosite match to PS00044 Bacterial regulatory proteins%2C lysR family signature. gene gene3460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3435 SCO3436 SCO3436 SCE36.03 SCE36.03 3797490 3799043 + fatty acid CoA ligase SCE36.03%2C possible fatty acid CoA ligase%2C len: 517 aa%3B similar to many eg. TR:O86483 (EMBL:AJ007932) acyl CoA ligase from Streptomyces argillaceus mithramycin biosynthesis cluster (514 aa) fasta scores%3B opt: 625%2C z-score: 678.0%2C E(): 1.9e-30%2C (32.7%25 identity in 513 aa overlap). Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and Prosite match to PS00455 AMP-binding domain signature. gene gene3461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3436 SCO3437 SCO3437 SCE36.04c SCE36.04c 3799715 3800455 - hypothetical protein SCE36.04c%2C possible integral membrane protein%2C len: 246aa%3B contains possible membrane spanning hydrophobic regions. gene gene3462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3437 SCO3438 SCO3438 SCE36.05c SCE36.05c 3800452 3801675 - hypothetical protein SCE36.05c%2C unknown%2C len: 407aa%3B contains a repeat region. gene gene3463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3438 SCO3439 SCO3439 SCE36.06 SCE36.06 3801757 3802629 + hypothetical protein SCE36.06%2C unknown%2C len: 290aa gene gene3464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3439 SCO3440 SCO3440 SCE36.07 SCE36.07 3802689 3803408 + hypothetical protein SCE36.07%2C unknown%2C len: 239aa gene gene3465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3440 SCO3441 SCO3441 SCE36.08 SCE36.08 3803405 3803974 + hypothetical protein SCE36.08%2C hypothetical protein%2C len: 189 aa. Contains possible N-terminal region signal peptide sequence gene gene3466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3441 SCO3442 SCO3442 SCE36.09 SCE36.09 3804032 3804376 + hypothetical protein SCE36.09%2C unknown%2C len: 114aa gene gene3467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3442 SCO3443 SCO3443 SCE36.10c SCE36.10c 3804673 3806037 - pyridine nucleotide-disulfide oxidoreductase SCE36.10c%2C probable pyridine nucleotide-disulphide oxidoreductase%2C len: 454 aa%3B similar to many eg. SW:MERA_STRLI mercuric reductase from Streptomyces lividans (474 aa) fasta scores%3B opt: 752%2C z-score: 772.0%2C E(): 0%2C (34.5%25 identity in 464 aa overlap). Contains Pfam match to entry PF00070 pyr_redox%2C Pyridine nucleotide-disulphide oxidoreductase class-I. gene gene3468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3443 SCO3444 SCO3444 SCE36.11c SCE36.11c 3806179 3808032 - hypothetical protein SCE46.01c%2C hypothetical protein (partial CDS)%2C len: >38 aa %3Bsimilar to TR:CAB52841 (EMBL:AL109848) Streptomyces coelicolor hypothetical 68.4 kD protein%3B fasta scores: opt: 152 z-score: 252.5 E(): 1e-06%3B 52.8%25 identity in 36 aa overlap~SCE36.11c%2C partial CDS%2C conserved hypothetical protein%2C len: 612aa%3B similar to TR:P71741 (EMBL:Z81368) hypothetical protein from Mycobacterium tuberculosis (642 aa) fasta scores%3B opt: 1283%2C z-score: 1479.1%2C E(): 0%2C (41.9%25 identity in 623 aa overlap) and SW:YAY3_SCHPO hypothetical protein from Schizosaccharomyces pombe (649 aa) fasta scores%3B opt: 883%2C z-score: 1017.4%2C E(): 0%2C (33.1%25 identity in 634 aa overlap). gene gene3469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3444 SCO3445 SCO3445 SCE46.02c SCE46.02c 3808168 3808335 - small membrane protein SCE46.02c%2C small membrane protein%2C len: 55 aa. Contains possible hydrophobic membrane spanning region gene gene3470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3445 SCO3446 SCO3446 SCE46.03c SCE46.03c 3808429 3809106 - dehalogenase SCE46.03c%2C possible dehalogenase%2C len: 225 aa%3B similar to SW:HAD_PSESP (EMBL:S74078) Pseudomonas sp. (strain YL) 2-haloalkanoic acid dehalogenase (EC 3.8.1.2)%2C 232 aa%3B fasta scores: opt: 243 z-score: 288.1 E(): 1.1e-08%3B 23.5%25 identity in 217 aa overlap. Contins match to Pfam entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene3471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3446 SCO3447 SCO3447 SCE46.04c SCE46.04c 3809247 3809930 - transcriptional regulator SCE46.04c%2C possible transcriptional regulatory protein%2C len: 227 aa%3B similar to TR:O53922 (EMBL:AL022002) Mycobacterium tuberculosis hypothetical 26.8kD protein MTV047.10c%2C 244 aa%3B fasta scores: opt: 486 z-score: 603.1 E(): 3e-26%3B 40.5%25 identity in 220 aa overlap. Contains Pfam matches to entries PF00325 crp%2C Bacterial regulatory proteins%2C crp family and PF00027 cNMP_binding%2C Cyclic nucleotide-binding domain. Contains a possible helix-turn-helix motif at residues 176..197 (+4.24 SD) gene gene3472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3447 SCO3448 SCO3448 SCE46.05c SCE46.05c 3809959 3810261 - hypothetical protein SCE46.05c%2C unknown%2C len: 100 aa gene gene3473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3448 SCO3449 SCO3449 SCE46.06c SCE46.06c 3810352 3810672 - hypothetical protein SCE46.06c%2C unknown%2C len: 106 aa gene gene3474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3449 SCO3450 SCO3450 SCE46.07c SCE46.07c 3810669 3811274 - ECF subfamily RNA polymerase sigma factor SCE46.07c%2C probable RNA polymerase sigma factor (ECF subfamily)%2C len: 201 aa%3B similar to TR:O87834 (EMBL:AJ010320) Streptomyces coelicolor RNA polymerase sigma factor SigR%2C 227 aa%3B fasta scores: opt: 337 z-score: 413.7 E(): 1.1e-15%3B 34.1%25 identity in 208 aa overlap and to SW:RPOE_MYCTU (EMBL:Z95120) Mycobacterium tuberculosis RNA polymerase sigma-E factor (sigma-24)%2C 216 aa%3B fasta socres: opt: 339 z-score: 416.4 E(): 7.5e-16%3B 35.4%25 identity in 189 aa overlap. Contains match to Pfam entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) and match to PS01063 Sigma-70 factors ECF subfamily signature. Contains also a possible helix-turn-helix motif at residues 159..180 (+3.23 SD) gene gene3475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3450 SCO3451 SCO3451 SCE46.08 SCE46.08 3811392 3811703 + hypothetical protein SCE46.08%2C unknown%2C len: 103 aa gene gene3476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3451 SCO3452 SCO3452 SCE46.09c SCE46.09c 3811766 3812845 - methyltransferase SCE46.09c%2C probable methyltransferase%2C len: 359 aa%3B similar to TR:AAF00618 (EMBL:AF166383) Mus musculus methyltransferase%2C 336 aa%3B fasta scores: opt: 868 z-score: 1022.0 E(): 0%3B 44.7%25 identity in 320 aa overlap and to SW:GRC2_LACLA (EMBL:L14679) Lactococcus lactis probable menaquinone biosynthesis methyltransferase (EC 2.1.1.-)%2C 252 aa%3B fasta scores: opt: 221 z-score: 265.2 E(): 2e-07%3B 38.7%25 identity in 111 aa overlap. Contains Pfam match to entry PF01209 Ubie_methyltran%2C ubiE/COQ5 methyltransferase family gene gene3477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3452 SCO3453 SCO3453 SCE46.10c SCE46.10c 3812961 3814025 - ABC-transporter ATP binding protein SCE46.10c%2C probable ABC-transporter ATP binding protein%2C len: 354 aa%3B similar to TR:CAB49712 (EMBL:AJ248285) Pyrococcus abyssi ABC-transporter ATP binding protein%2C 329 aa%3B fasta scores opt: 708 z-score: 742.4 E(): 0%3B 43.9%25 identity in 280 aa overlap and to SW:CYSA_ECOLI (EMBL:M32101) Escherichia coli sulfate transport ATP-binding protein CysA%2C 365 aa%3B fasta scores: opt: 668 z-score: 700.3 E(): 1.2e-31%3B 38.6%25 identity in 332 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and two matches to Prosite entries PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3453 SCO3454 SCO3454 SCE46.11c SCE46.11c 3814031 3814873 - ABC-transporter membrane protein SCE46.11c%2C possible ABC-transporter membrane protein%2C len: 280 aa%3B similar to TR:Q44381 (EMBL:U60011) Agrobacterium tumefaciens inner membrane protein MotD%2C 273 aa%3B fasta scores: opt: 360 z-score: 418.0 E(): 6.1e-16%3B 29.3%25 identity in 256 aa overlap and to SW:POTC_ECOLI (EMBL:M64519) Escherichia coli spermidine/putrescine transport system permease PotC%2C 264 aa%3B fasta scores: opt: 309 z-score: 360.4 E(): 1e-12%3B 25.8%25 identity in 260 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible N-terminal region signal peptide sequence. Contains also a possible helix-turn-helix motif at residues 159..180 (+3.23 SD) gene gene3479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3454 SCO3455 SCO3455 SCE46.12c SCE46.12c 3814870 3815727 - ABC-transporter transport protein SCE46.12c%2C possible ABC-transporter transport protein%2C len: 285 aa%3B similar to TR:O57756 (EMBL:AP000001) Pyrococcus horikoshii 284 aa long hypothetical sugar transport membrane protein%2C 284 aa%3B fasta scores: opt: 281 z-score: 329.5 E(): 5.2e-11%3B 26.6%25 identity in 278 aa overlap and to SW:UGPA_ECOLI (EMBL:X13141) Escherichia coli SN-glycerol-3-phosphate transport system permease UgpA%2C 295 aa%3B fasta scores: opt: 233 z-score: 274.6 E(): 6e-08%3B 28.7%25 identity in 279 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains possible N-terminal region signal peptide sequence gene gene3480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3455 SCO3456 SCO3456 SCE46.13c SCE46.13c 3815736 3816989 - ABC transporter substrate-binding protein SCE46.13c%2C possible hypothetical protein%2C len: 135 aa%3B similar to TR:CAC41457 (EMBL:AL591782) Rhizobium meliloti conserved hypothetical protein SMC02589%2C 408 aa%3B fasta scores: opt: 927 Z-score: 1029.9 E(): 9.8e-50%3B 37.198%25 identity in 414 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3456 SCO3457 SCO3457 SCE46.14 SCE46.14 3817153 3817770 + transmembrane protein SCE46.14%2C possible transmembrane protein%2C len: 205 aa%3B similar to TR:P76226 (EMBL:AE000270) Escherichia coli from bases 1830199 to 1840304%2C 208 aa%3B fasta scores: opt: 402 z-score: 471.0 E(): 6.9e-19%3B 37.4%25 identity in 206 aa overlap and to TR:CAB50482 (EMBL:AJ248288) Pyrococcus abyssi predicted CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PgsA%2C 185 aa%3B fasta scores: opt: 216 z-score: 259.1 E(): 4.4e-07%3B 31.2%25 identity in 205 aa overlap gene gene3482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3457 SCO3458 SCO3458 SCE46.15c SCE46.15c 3817745 3818494 - hypothetical protein SCE46.15c possible integral membrane protein%2C len: 249 aa%3B similar to various hypothetical proteins%2C e.g. SW:Y305_SYNY3 (EMBL:D64005) Synechocystis sp. hypothetical 22.2 kD protein SLR0305%2C 209 aa%3B fasta scores: opt: 419 z-score: 450.0 E(): 1e-17%3B 39.8%25 identity in 161 aa overlap gene gene3483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3458 SCO3459 SCO3459 SCE46.16c SCE46.16c 3818491 3819354 - hypothetical protein SCE46.16c%2C hypothetical protein%2C len: 287 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB52055 (EMBL:AL109732) Streptomyces coelicolor hypothetical 24.3kD protein%3B fasta scores: opt: 165 z-score: 195.9 E(): 0.0014%3B 37.4%25 identity in 131 aa overlap gene gene3484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3459 SCO3460 SCO3460 SCE46.17 SCE46.17 3819415 3820932 + oxidoreductase SCE46.17%2C probable oxidoreductase%2C len: 505 aa%3B similar to SW:MERA_STAAU (EMBL:L29436) Staphylococcus aureus mercuric reductase (EC 1.16.1.1) MerA%2C 547 aa%3B fasta scores: opt: 891 z-score: 971.7 E(): 0%3B 37.4%25 identity in 452 aa overlap. Contains match to Prosite entry PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site gene gene3485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3460 SCO3461 SCO3461 SCE46.18 SCE46.18 3820929 3821387 + hypothetical protein SCE46.18%2C possible integral membrane protein%2C len: 152 aa%3B similar to SW: MAUE_PARDE (EMBL:X98581) Paracoccus denitrificans methylamine utilization protein MauE%2C 186 aa%3B fasta scores: opt: 162 z-score: 208.6 E(): 0.00028%3B 28.1%25 identity in 139 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3461 SCO3462 SCO3462 SCE46.19 SCE46.19 3821387 3822823 + hypothetical protein SCE46.19%2C unknown%2C len: 478 aa gene gene3487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3462 SCO3463 SCO3463 SCE46.20 SCE46.20 3822850 3823638 + phosphorylase SCE46.20%2C probable phosphorylase%2C len: 262 aa%3B similar to TR:O58891 (EMBL:AP000005) Pyrococcus horikoshii 265 aa long hypothetical 5'-methylthioadenosine phosphorylase PH1143 265 aa%3B fasta scores: opt: 461 z-score: 534.1 E(): 2.1e-22%3B 35.1%25 identity in 251 aa overlap and to SW:MTAP_HUMAN (EMBL:U22233) Homo sapiens 5'-methylthioadenosine phosphorylase (EC 2.4.2.28) MtaP%2C 283 aa%3B fasta scores: opt: 373 z-score: 433.4 E(): 8.6e-17%3B 32.4%25 identity in 216 aa overlap. Contains Pfam match to entry PF00896 Mtap_PNP%2C phosphorylases family 2 gene gene3488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3463 SCO3464 SCO3464 SCE46.21 SCE46.21 3823677 3824309 + hypothetical protein SCE46.21%2C hypothetical protein%2C len: 210 aa%3B identical to N-terminal region of previously sequenced TR:BAA84086 (EMBL:AB032065) Streptomyces coelicolor hypothetical 47.9 kD protein%2C 446 aa and similar to TR:P74231 (EMBL:D90913) Synechocystis sp. (strain PCC 6803) hypothetical 23.5 kD protein%2C 211 aa%3B fasta scores: opt: 327 z-score: 394.6 E(): 1.2e-14%3B 36.5%25 identity in 189 aa overlap. Contains plasmid SCP1 integration target site gene gene3489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3464 SCO3465 SCO3465 SCE46.22 SCE46.22 3824306 3825016 + hypothetical protein SCE65.01%2C hypothetical protein (partial CDS)%2C len: >38 aa%3B identical to previously sequenced TR:BAA84086 (EMBL:AB032065) Streptomyces ceolicolor hypothetical 47.9 KD protein%2C 446 aa~SCE46.22%2C hypothetical protein%2C len: >231 aa%3B identical to C-terminal region of previously sequenced TR:BAA84086 (EMBL:AB032065) Streptomyces coelicolor hypothetical 47.9 kD protein%2C 446 aa. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene3490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3465 SCO3466 SCO3466 IS468B IS468B 3825371 3826210 + transposase SCE65.02%2C IS468B%2C transposase%2C len: 279 aa%3B identical to previously sequenced TR:BAA84088 (EMB:AB032065) Streptomyces coelicolor transposase IS468B-ORF%2C to Streptomyces coelicolor SCE65.03 and to Streptomyces coelicolor SCJ11.27c. Contains Pfam matches to entry PF01675 Transposase_13%2C Transposase and to entry PF01511 Transposase_6%2C Transposase gene gene3491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3466 SCO3467 SCO3467 IS468B IS468B 3826473 3827312 + transposase SCE65.03%2C IS468B%2C transposase%2C len: 279 aa%3B identical to previously sequenced TR:BAA84088 (EMB:AB032065) Streptomyces coelicolor transposase IS468B-ORF%2C to S. coelicolor SCE65.02 and to S. coelicolor SCJ11.27c. Contains Pfam matches to entry PF01675 Transposase_13%2C Transposase and to entry PF01511 Transposase_6%2C Transposase gene gene3492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3467 SCO3468 SCO3468 IS469 IS469 3827457 3828962 + transposase SCE65.04%2C IS469%2C transposase%2C len: 501 a%3B identical to previously sequenced TR:BAA84089 (EMBL:AB032065) Streptomyces coelicolor IS469-ORF%2C 501 aa%2C to Streptomyces coelicolor SCE65.26 and highly similar to Streptomyces coelicolor SCE65.05c%2C 513 aa%3B fasta scores: opt: 2079 z-score: 2166.3 E(): 0%3B 63.7%25 identity in 501 aa overlap. Contains Leucine TTA codon%2C possible target for bldA regulation gene gene3493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3468 SCO3469 SCO3469 IS469 IS469 3829043 3830584 - transposase SCE65.05c%2C IS469%2C transposase%2C len: 513 aa%3B identical to previously sequenced TR:BAA84089 (EMBL:AB032065) Streptomyces coelicolor IS469-ORF%2C 501 aa%2C to Streptomyces coelicolor SCE65.26 and highly similar to Streptomyces coelicolor SCE65.04%2C 501 aa%3B fasta scores: opt: 2079 z-score: 2040.2 E(): 0%3B 63.7%25 identity in 501 aa overlap. Contains Pfam match to entry PF01610 Transposase_12%2C Transposase. Also contains Leucine TTA codon%2C possible target for bldA regulation and a possible helix-turn-helix motif at residues 219..312 (+3.15 SD) gene gene3494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3469 SCO3470 SCO3470 IS470 IS470 3830698 3831525 - transposase SCE65.06c%2C IS470%2C transposase%2C len: 275 aa%3B identical to previously sequenced TR:BAA84091 (EMBL:AB032065) Streptomyces coelicolor transposase IS470-ORF%2C 275 aa gene gene3495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3470 SCO3471 SCO3471 dagA dagA 3831705 3832634 - extracellular agarase SCE65.07c%2C dagA%2C extracellular agarase precursor%2C len: 309 aa%3B identical to previously sequenced SW:AGAR_STRCO (EMBL:X05811) Streptomyces coelicolor extracellular agarase precursor (EC 3.2.1.81) DagA%2C 309 aa and similar to TR:Q59078 (EMBL:M73783) Alteromonas atlantica (Pseudomonas atlantica) beta-agarase I precursor (EC 3.2.1.81)%2C 290 aa%3B fasta scores: opt: 385 z-score: 446.1 E(): 1.8e-17%3B 33.2%25 identity in 304 aa overlap. Contains match to Prosite entry PS01034 Glycosyl hydrolases family 16 active sites. Contains N-terminal region signal sequence peptide gene gene3496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3471 SCO3472 SCO3472 SCE65.08c SCE65.08c 3832988 3833251 - transposase remnant SCE65.08c%2C possible transposase remnant%2C len: 87 aa%3B similar to TR:P71428 (EMBL:X02734) Lactobacillus casei transposable element ISL1%2C 93 aa%3B fasta scores: opt: 98 z-score: 145.6 E(): 0.91%3B 31.5%25 identity in 54 aa overlap and to Streptomyces coelicolor SCE65.24%2C 114 aa%3B fasta scores: opt: 76 z-score: 102.7 E(): 2.3%3B 40.6%25 identity in 32 aa overlap gene gene3497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3472 SCO3473 SCO3473 SCE65.09c SCE65.09c 3834055 3834702 - aldolase SCE65.09c%2C probable aldolase%2C len: 215 aa%3B similar to SW:ALKH_BACSU (EMBL:L47838) Bacillus subtilis KHG/KDPG aldolase AlkH%2C 347 aa%3B fasta scores: opt: 457 z-score: 523.2 E(): 9.1e-22%3B 39.5%25 identity in 200 aa overlap and to Streptomyces coelicolor SCE65.31c%2C 225 aa%3B fasta scores: opt: 424 z-score: 429.4 E(): 1.5e-18%3B 37.7%25 identity in 215 aa overlap. Contains Pfam match to entry PF01081 Aldolase%2C KDPG and KHG aldolase and match to Prosite entry PS00160 KDPG and KHG aldolases Schiff-base forming residue gene gene3498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3473 SCO3474 SCO3474 SCE65.10c SCE65.10c 3834741 3835742 - sugar kinase SCE65.10c%2C possible sugar kinase%2C len: 333 aa%3B similar to SW:KDGK_BACSU (EMBL:L47838) Bacillus subtilis 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) KdgK%2C 324 aa%3B fasta scores: opt: 500 z-score: 585.4 E(): 3.1e-25%3B 34.1%25 identity in 299 aa overlap. Contains Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase gene gene3499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3474 SCO3475 SCO3475 SCE65.11c SCE65.11c 3835870 3837003 - galactonate dehydratase SCE65.11c%2C possible isomerase%2C len: 377 aa%3B similar to SW:ATB_RHOOP (EMBL:X99622) Rhodococcus opacus muconate cycloisomerase I (EC 5.5.1.1) CatB%2C 373 aa%3B fasta scores: opt: 390 z-score: 443.3 E(): 2.6e-17%3B 31.1%25 identity in 357 aa overlap. Contains Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2 gene gene3500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3475 SCO3476 SCO3476 SCE65.12c SCE65.12c 3837216 3837971 - short-chain dehydrogenase SCE65.12c%2C probable dehydrogenase%2C len: 251 aa%3B similar to SW:KDUD_BACSU (EMBL:L47838) Bacillus subtilis 2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) KduD%2C 254 aa%3B fasta scores: opt: 833 z-score: 937.8 E(): 0%3B 52.0%25 identity in 248 aa overlap and to Streptomyces coelicolor SCI30A.02%2C 253 aa%3B fasta scores: opt: 605 z-score: 622.2 E(): 2.7e-29%3B 44.1%25 identity in 245 aa overlap. Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase and to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene3501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3476 SCO3477 SCO3477 SCE65.13c SCE65.13c 3837968 3839002 - dehydrogenase SCE65.13c%2C possible dehydrogenase%2C len: 344 aa%3B similar to TR:CAB50292 (EMBL:AJ248287) Pyrococcus abyssi threonine 3-dehydrogenase (EC 1.1.1.103) 348 aa%3B fasta scores: opt: 567 z-score: 616.8 E(): 5.6e-27%3B 33.8%25 identity in 328 aa overlap and to SW:TDH_BACSU (EMBL:Z99112) threonine 3-dehydrogenase (EC 1.1.103) Tdh%2C 347 aa%3B fasta scores: opt: 544 z-score: 592.1 E(): 1.3e-25%3B 31.4%25 identity in 331 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene3502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3477 SCO3478 SCO3478 SCE65.14c SCE65.14c 3838999 3840033 - dehydrogenase SCE65.14c%2C probable dehydrogenase%2C len: 344 aa%3B similar to TR:O50095 (EMBL:AP000006) Pyrococcus horikoshii 307aa long hypothetical phosphoglycerate dehydrogenase PH1387%2C 307 aa%3B fasta scores: opt: 687 z-score: 777.1 E(): 0%3B 40.5%25 identity in 291 aa overlap and to SW:SERA_METTH (EMBL:AE000870%3B) Methanobacterium thermoautotrophicum D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA%2C 525 aa%3B fasta scores: opt: 664 z-score: 748.1 E(): 0%3B 39.0%25 identity in 282 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2 gene gene3503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3478 SCO3479 SCO3479 SCE65.15c SCE65.15c 3840395 3843382 - beta-galatosidase SCE65.15c%2C possible beta-galatosidase%2C len: 995 aa%3B similar to SW:BGAL_ECOLI (EMBL:J01636) Escherichia coli beta-galactosidase (EC 3.2.1.23) (lactase) lacZ%2C 1023 aa%3B fasta scores: opt: 1594 z-score: 1693.3 E(): 0%3B 33.6%25 identity in 1039 aa overlap. Contains Pfam match to entry PF00703 Glyco_hydro_2%2C Glycosyl hydrolases family and match to Prosite entry PS00719 Glycosyl hydrolases family 2 signature 1 gene gene3504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3479 SCO3480 SCO3480 SCE65.16c SCE65.16c 3843523 3844608 - racemase SCE65.16c%2C possible racemase%2C len: 361 aa%3B similar to TR:CAB55709 (EMBL:AL117387) Streptomyces coelicolor possible racemase SCF41.06%2C 416 aa%3B fasta scores: opt: 471 z-score: 557.6 E(): 1.1e-23%3B 32.6%25 identity in 328 aa overlap and to SW:MANR_PSEPU (EMBL:M19043) Pseudomonas putida mandelate racemase (EC 5.1.2.2) MdlA%2C 359 aa%3B fasta scores: opt: 473 z-score: 561.0 E(): 7.2e-24%3B 27.8%25 identity in 363 aa overlap. Contains Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family and match to Prosite entry PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2 gene gene3505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3480 SCO3481 SCO3481 SCE65.17c SCE65.17c 3844670 3845782 - hypothetical protein SCE65.17c unknown%2C len: 370 aa gene gene3506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3481 SCO3482 SCO3482 SCE65.18c SCE65.18c 3845809 3846690 - sugar-permease SCE65.18c%2C possible sugar-permease%2C len: 293 aa%3B similar to TR:P72399 (EMBL:Y07706) Streptomyces coelicolor maltose permease MalG%2C 302 aa%3B fasta scores: opt: 491 z-score: 561.6 E(): 6.6e-24%3B 28.2%25 identity in 301 aa overlap. Contains match to Pfam entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains possible N-terminal region signal peptide sequence gene gene3507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3482 SCO3483 SCO3483 SCE65.19c SCE65.19c 3846702 3847649 - integral membrane transport protein SCE65.19c%2C probable integral membrane transport protein%2C len: 315 aa%3B similar to TR:O50452 (EMBL:AL021006) Mycobacterium tuberculosis probable sugar transport protein MTV006.08%2C 307 aa%3B fasta scores: opt: 542 z-score: 668.9 E(): 7e-30%3B 32.6%25 identity in 288 aa overlap. Contains match to Pfam entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and possible N-terminal region signal peptide sequence gene gene3508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3483 SCO3484 SCO3484 SCE65.20c SCE65.20c 3847685 3848995 - sugar-binding protein SCE65.20c%2C possible sugar-binding protein%2C len: 436 aa%3B similar to TR:P72397 (EMBL:Y07706) Streptomyces coelicolor maltose-binding protein MalE%2C 423 aa%3B fasta scores: opt: 361 z-score: 398.4 E(): 8.1e-15%3B 26.2%25 identity in 409 aa overlapand to TR:O87856 (EMBL:AL031013) Streptomyces coelicolor sugar binding protein SC8A6.22%2C 438 aa%3B fasta scores: opt: 344 z-score: 379.6 E(): 9e-14%3B 23.6%25 identity in 365 aa overlap. Contains match to Pfam entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and match to Prosite entry correctly situated PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains possible N-terminal signal peptide sequence gene gene3509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3484 SCO3485 SCO3485 SCE65.21c SCE65.21c 3849177 3850226 - LacI family transcriptional regulator SCE65.21c%2C probable lacI-family transcriptional regulator%2C len: 349 aa%3B similar to TR:AAD42741 (EMBL:AF105219) Thermomonospora curvata regulatory protein AglR%2C 347 aa%3B fasta scores: opt: 563 z-score: 648.1 E(): 1e-28%3B 34.9%25 identity in 341 aa overlap and to SW:CYTR_ECOLI (EMBL:X03683) Escherichia coli%2C transcriptional repressor CytR 341 aa%3B fasta scores: opt: 552 z-score: 635.6 E(): 5e-28%3B 30.5%25 identity in 347 aa overlap. Contains matches to Pfam entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI. Contains probable helix-turn-helix motif at residues 18..39 (+4.84 SD) gene gene3510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3485 SCO3486 SCO3486 SCE65.22 SCE65.22 3850388 3851866 + aldehyde dehydrogenase SCE65.22%2C probable aldehyde dehydrogenase%2C len: 492 aa%3B similar to SW:ALDA_ECOLI (EBML:M64541) Escherichia coli aldehyde dehydrogenase A (EC 1.2.1.22) aldA%2C 478 aa%3B fasta scores: opt: 1189 z-score: 1347.0 E(): 0%3B 39.1%25 identity in 473 aa overlap and to Streptomyces coelicolor SCI35.34c%2C 483 aa%3B fasta scores: opt: 1014 z-score: 940.7 E(): 0%3B 40.2%25 identity in 455 aa overlap. Contains match to Pfam entry PF00171 aldedh%2C Aldehyde dehydrogenase and two matches to Prosite entries PS00687 Aldehyde dehydrogenases glutamic acid active site PS00070 Aldehyde dehydrogenases cysteine active site gene gene3511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3486 SCO3487 SCO3487 SCE65.23 SCE65.23 3852249 3854645 + hydrolase SCE65.23%2C possible hydrolase%2C len: 798 aa%3B similar to SW:AGAB_VIBS7 (EMBL:D21202) Vibrio sp. (strain JT0107) beta-agarase B (EC 3.2.1.81) AgaB%2C 955 aa%3B fasta socres: opt: 1394 z-score: 1581.4 E(): 0%3B 39.0%25 identity in 772 aa overlap. Contains possible hydrophobic membrane spanning region and Leucine TTA codon%2C possible target for bldA regulation gene gene3512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3487 SCO3488 SCO3488 SCE65.24 SCE65.24 3854814 3855331 + gene gene3513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3488 SCO3490 SCO3490 IS466A IS466A 3855405 3856946 + transposase SCE65.26%2CIS466A%2C transposase%2C len: 513 aa%3B identical to previously sequenced TR:BAA84090 (EMBL:AB032065) Streptomyces coelicolor transposase IS466A-ORF%2C 513 aa and identical also to previosuly sequenced TR:CAB52795 (EMBL:AJ245804) Streptomyces coelicolor transposase TnpA%2C 513 aa%2C to Streptomyces coelicolor SCE65.05c and higly similar to Streptomyces coelicolor SCE65.04%2C 501 aa%3B fasta scores: opt: 2079 z-score: 2040.2 E(): 0%3B 63.7%25 identity in 501 aa overlap. Contains Leucine TTA codon%2C possible target for bldA regulation and a possible helix-turn-helix motif at residues 291..312 (+3.15 SD) gene gene3514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3490 SCO3491 SCO3491 SCE65.27 SCE65.27 3857600 3858133 + transmembrane protein SCE65.27%2C possible transmembrane protein%2C len: 177 aa%3B highly similar to TR:CAB41065 (EMBL:AL049645) Streptomyces coelicolor hypothetical 15.4 KD protein SCE2.06%2C 146 aa%3B fasta scores: opt: 780 z-score: 972.8 E(): 0%3B 90.9%25 identity in 132 aa overlap gene gene3515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3491 SCO3492 SCO3492 SCE65.28c SCE65.28c 3858303 3858431 - hypothetical protein SCE65.28c%2C unknown%2C len: 42 aa gene gene3516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3492 SCO3493 SCO3493 SCE65.29c SCE65.29c 3858421 3859008 - acetyl transferase SCE65.29c%2C possible acetyl transferase%2C len: 195 aa%3B similar to TR:AAD15402 (EMBL:AC006223) Arabidopsis thaliana alanine acetyl transferase F22D22.23%2C 183 aa%3B fasta scores: opt: 208 z-score: 273.8 E(): 7.1e-08%3B 30.8%25 identity in 172 aa overlap and to SW:ATDA_ECOLI (EMBL:D25276) Escherichia coli spermidine N1-acetyltransferase (EC 2.3.1.57) SpeG%2C 185 aa%3B fasta scores: opt: 163 z-score: 216.7 E(): 0.00011%3B 23.6%25 identity in 174 aa overlap. Contains match to Pfam entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene3517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3493 SCO3494 SCO3494 SCE65.30c SCE65.30c 3859063 3860043 - sugar kinase SCE65.30c%2C probable sugar kinase%2C len: 326 aa%3B similar to TR:Q9ZFM1 (EMBL:AF098273) Bacillus stearothermophilus 2-keto-3-deoxy-gluconate kinase KdgK%2C 314 aa%3B fasta scores: opt: 598 z-score: 671.6 E(): 4.9e-30%3B 37.0%25 identity in 308 aa overlap and to SW:KDGK_BACSU (EMBL:L47838) Bacillus subtilis 2-dehydro-3-deoxygluconokinase (EC 2.7.1.4) KdgK%2C 324 aa%3B fasta scores: opt: 560 z-score: 629.2 E(): 1.1e-27%3B 35.4%25 identity in 311 aa overlap. Contains match to Pfam entry PF00294 pfkB%2C pfkB family carbohydrate kinase and match to Prosite entry PS00584 pfkB family of carbohydrate kinases signature 2 gene gene3518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3494 SCO3495 SCO3495 SCE65.31c SCE65.31c 3860040 3860717 - aldolase SCE65.31c probable aldolase%2C len: 225 aa%3B similar to TR:AAD35160 (EMBL:AE001693) Thermotoga maritima 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase TM0066%2C 205 aa%3B fasta scores: opt: 437 z-score: 460.7 E(): 2.8e-18%3B 39.1%25 identity in 174 aa overlap and to SW:ALKH_BACSU (EMBL:L47838) Bacillus subtilis Khg/KdpG aldolase KdgA%2C 196 aa %3Bfasta scores: opt: 379 z-score: 401.8 E(): 5.3e-15%3B 37.9%25 identity in 177 aa overlap. Contains match to Pfam entry PF01081 Aldolase%2C KDPG and KHG aldolase gene gene3519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3495 SCO3496 SCO3496 SCE65.32c SCE65.32c 3861209 3862690 - lyase SCE65.32c%2C possible lyase precursor%2C len: 493 aa%3B low similarity to SW:ALYP_PSESO (EMBL:D10336) Pseudomonas sp. (strain OS-ALG-9) alginate lyase precursor (EC 4.2.2.3) (poly(beta-D-mannuronate) lyase) (poly(ManA) alginate lyase) Aly or AlyP%2C 398 aa%3B fasta scores: opt: 550 z-score: 593.8 E(): 1.1e-25%3B 29.5%25 identity in 380 aa overlap. Contains possible signal peptide sequence and also a Leucine TTA codon%2C possible target for bldA regulation gene gene3520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3496 SCO3497 SCO3497 SCE65.33c SCE65.33c 3863148 3863927 - polyguluronate lyase SCE65.33c%2C probable polyguluronate lyase precursor%2C len: 259 aa%3B highly similar to TR:BAA83339 (EMBL:AB030481) Corynebacterium sp. ALY-1 polyguluronate lyase precursor (EC 4.2.2.11) AlyPG%2C 256 aa%3B fasta scores: opt: 1329 z-score: 1518.4 E(): 0%3B 76.9%25 identity in 260 aa overlap. Contains possible N-terminal signal peptide sequence gene gene3521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3497 SCO3498 SCO3498 SCE65.34c SCE65.34c 3863976 3865052 - hypothetical protein SCE65.34c%2C possible hypothetical protein%2C len: 358 aa%3B similar to TR:P94576 (EMBL:Z82987) Bacillus subtilis hypothetical 51.5 kD protein YwoF%2C 468 aa%3B fasta scores: opt: 171 z-score: 188.8 E(): 0.0038%3B 24.1%25 identity in 403 aa overlap. Contains possible N-terminal region signal peptide sequence and Leucine TTA codon%2C possible target for bldA regulation gene gene3522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3498 SCO3499 SCO3499 SCE65.35c SCE65.35c 3865049 3865636 - hypothetical protein SCE65.35c%2C possible integral membrane protein%2C len: 585 aa. Contains possible hydrophobic membrane spanning regions gene gene3523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3499 SCO3500 SCO3500 SCE134.01c SCE134.01c 3865647 3867689 - hypothetical protein SCE134.01c%2C partial CDS%2C unknown%2C len: >671aa%3B~SCE65.36c%2C unknown (partial CDS)%2C len: >41 aa%3B identical to previously sequenced TR:CAB41199 (EMBL:AL049661) Streptomyces coelicolor SCE134.01c gene gene3524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3500 SCO3501 SCO3501 SCE134.02c SCE134.02c 3867696 3869381 - hypothetical protein SCE134.02c%2C unknown%2C len: 561aa gene gene3525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3501 SCO3502 SCO3502 SCE134.03c SCE134.03c 3869438 3870205 - 3-oxoacyl-ACP reductase SCE134.03c%2C possible 3-oxoacyl-[acyl carrier protein] reductase%2C len: 255 aa%3B similar to many e.g. SW:FABG_BACSU 3-oxoacyl-[acyl carrier protein] reductase from Bacillus subtilis (246 aa) fasta scores%3B opt: 522%2C z-score: 518.3%2C E(): 1.5e-21%2C (38.1%25 identity in 247 aa overlap). Contains Pfam matches to entries PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and PF00106 adh_short%2C short chain dehydrogenase. gene gene3526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3502 SCO3503 SCO3503 SCE134.04c SCE134.04c 3870261 3871100 - binding protein dependent transport protein SCE134.04c%2C possible binding protein dependent transport protein%2C len: 279aa%3B similar to many egs. SW:YURM_BACSU hypothetical ABC transporter permease from Bacillus subtilis (300 aa) fasta scores%3B opt: 424%2C z-score: 513.6%2C E(): 2.7e-21%2C (32.4%25 identity in 281 aa overlap) and SW:UGPE_ECOLI Sn-glycerol-3-phosphate transport permease from Escherichia coli (281 aa) fasta scores%3B opt: 350%2C z-score: 425.7%2C E(): 2.1e-16%2C (29.6%25 identity in 284 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene3527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3503 SCO3504 SCO3504 SCE134.05c SCE134.05c 3871177 3872160 - binding protein dependent transport protein SCE134.05c%2C possible binding protein dependent transport protein%2C len: 327aa%3B similar to many egs. SW:YURN_BACSU hypothetical ABC transporter permease from Bacillus subtilis (292 aa) fasta scores%3B opt: 586%2C z-score: 707.9%2C E(): 4.1e-32%2C (32.4%25 identity in 287 aa overlap) and SW:UGPA_ECOLI Sn-glycerol-3-phosphate transport permease from Escherichia coli (295 aa) fasta scores%3B opt: 583%2C z-score: 704.3%2C E(): 6.5e-32%2C (33.8%25 identity in 290 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp signature. gene gene3528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3504 SCO3505 SCO3505 SCE134.06c SCE134.06c 3872165 3873454 - substrate binding protein SCE134.06c%2C possible substrate binding protein%2C len: 429aa%3B weak similarity to many egs. TR:O87856 (EMBL:AL031013) sugar binding protein from Streptomyces coelicolor (438 aa) fasta scores%3B opt: 368%2C z-score: 408.8%2C E(): 1.9e-15%2C (26.2%25 identity in 428 aa overlap) and SW:MALE_ECOLI maltose-binding protein from Escherichia coli (396 aa) fasta scores%3B opt: 188%2C z-score: 211.5%2C E(): 0.00018%2C (23.0%25 identity in 374 aa overlap). Contains probable N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene3529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3505 SCO3506 SCO3506 SCE134.07 SCE134.07 3873615 3874676 + LacI family transcriptional regulator SCE134.07%2C possible lacI-family transcriptional regulator%2C len: 353 aa%3B similar to many e.g. SW:MALR_STRCO maltose operon transcriptional repressor MalR from Streptomyces coelicolor (344 aa) fasta scores%3B opt: 440%2C z-score: 508.9%2C E(): 4.9e-21%2C (32.4%25 identity in 352 aa overlap). Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family. gene gene3530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3506 SCO3507 SCO3507 SCE134.08 SCE134.08 3874761 3876263 + integral membrane efflux protein SCE134.08%2C possible integral membrane efflux protein%2C len: 500aa%3B similar to many mostly involved in antibiotic efflux eg. TR:Q50396 (EMBL:U46844) from the ethambutol resistance gene cluster of Mycobacterium tuberculosis (412 aa) fasta scores%3B opt: 780%2C z-score: 854.0%2C E(): 0%2C (36.7%25 identity in 401 aa overlap). Contains several possible membrane spanning hydrophobic regions. gene gene3531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3507 SCO3508 SCO3508 SCE134.09 SCE134.09 3877191 3877628 + maturase-like protein SCE134.09%2C possible maturase-related protein%2C len: 145aa%3B similar to many proposed maturase-related protein from prokaryotes eg. TR:O53616 (EMBL:AL021428) maturase homolog from Mycobacterium tuberculosis (235 aa) fasta scores%3B opt: 251%2C z-score: 315.3%2C E(): 3e-10%2C (56.9%25 identity in 72 aa overlap). gene gene3532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3508 SCO3509 SCO3509 SCE134.10 SCE134.10 3877697 3878659 + hypothetical protein SCE134.10%2C unknown%2C len: 320 aa%3B weakly similar to SW:YD75_HAEIN hypothetical protein from Haemophilus influenzae (302 aa) fasta scores%3B opt: 308%2C z-score: 377.0%2C E(): 1.1e-13%2C (23.6%25 identity in 301 aa overlap) and similar to TR:Q9L1X0 (EMBL:AL138667) Streptomyces coelicolor hypothetical protein SC3D9.09%2C 350 aa%3B fasta scores: opt: 589 Z-score: 696.5 E(): 3.6e-31%3B 46.006%25 identity in 313 aa overlap gene gene3533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3509 SCO3510 SCO3510 SCE134.11c SCE134.11c 3878757 3879503 - DNA methylase SCE134.11c%2C possible DNA methylase%2C len: 248 aa%3B similar to many e.g. TR:O68789 (EMBL:AF053947) adenine methyltransferase homolog from Yersinia pestis (213 aa) fasta scores%3B opt: 246%2C z-score: 300.2%2C E(): 2.1e-09%2C (30.8%25 identity in 224 aa overlap). Contains Prosite match to PS00092 N-6 Adenine-specific DNA methylases signature. gene gene3534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3510 SCO3511 SCO3511 SCE134.12 SCE134.12 3880083 3881228 + lipoprotein SCE134.12%2C possible lipoprotein%2C len: 381aa%3B similar to many%2C mostly hypotheticals%2C eg. TR:P71594 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (281 aa) fasta scores%3B opt: 288%2C z-score: 295.1%2C E(): 4e-09%2C (40.9%25 identity in 132 aa overlap). Also similar to SW:SPR_ECOLI lipoprotein Spr precusror from Escherichia coli (188 aa) fasta scores%3B opt: 201%2C z-score: 211.7%2C E(): 0.00018%2C (37.2%25 identity in 113 aa overlap). Contains a possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family domain of unknown function. gene gene3535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3511 SCO3512 SCO3512 SCE134.13 SCE134.13 3881317 3881625 + hypothetical protein SCE134.13%2C possible integral membrane protein%2C len: 102 aa%3B similar to TR:Q9L1N2 (EMBL:AL138977) Streptomyces coelicolor membrane protein SC7F9.35c%2C 104 aa%3B fasta scores: opt: 545 Z-score: 647.4 E(): 2e-28%3B 79.412%25 identity in 102 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3512 SCO3513 SCO3513 SCE134.14 SCE134.14 3881625 3882305 + hypothetical protein SCE134.14%2C possible hypothetical protein%2C len: 226 aa. Contains possible N-terminal region signal peptide sequence gene gene3537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3513 SCO3514 SCO3514 SCE134.15 SCE134.15 3882333 3883742 + ATP-binding protein SCE134.15%2C possible integral membrane ATP-binding protein%2C len: 469aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible membrane spanning hydrophobic regions. gene gene3538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3514 SCO3515 SCO3515 SCE134.16 SCE134.16 3883874 3885340 + hypothetical protein SCE134.16%2C possible integral membrane protein%2C len: 488aa%3B contains a possible membrane spanning hydrophobic region. gene gene3539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3515 SCO3516 SCO3516 SCE134.17 SCE134.17 3885367 3885819 + hypothetical protein SCE134.17%2C unknown%2C len: 150aa gene gene3540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3516 SCO3517 SCO3517 SCE134.18 SCE134.18 3885882 3887351 + ATP-binding protein SCE134.18%2C possible ATP-binding protein%2C len: 489aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Similar to TR:Q9L1N7 (EMBL:AL138977) from Streptomyces coelicolor (507 aa) fasta scores%3B opt: 2405%2C Z-score: 2578.8%2C 73.469%25 identity (75.000%25 ungapped) in 490 aa overlap. gene gene3541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3517 SCO3518 SCO3518 SCE134.19 SCE134.19 3887444 3888079 + hypothetical protein SCE134.19%2C unknown%2C len: aa gene gene3542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3518 SCO3519 SCO3519 SCE134.20 SCE134.20 3888210 3888821 + hypothetical protein SCE134.20%2C unknown%2C len: 203aa gene gene3543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3519 SCO3520 SCO3520 SCE134.21 SCE134.21 3888872 3889636 + hypothetical protein SCE2.01%2C unknown%2C len: 254aa%3B~SCE134.21%2C partial CDS%2C unknown%2C len: >203aa gene gene3544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3520 SCO3521 SCO3521 SCE2.02c SCE2.02c 3889752 3890456 - hypothetical protein SCE2.02c%2C possible integral membrane protein%2C len: 234 aa%3B similar to TR:P96876 (EMBL:Z92771) hypothetical protein from Mycobacterium tuberculosis (222 aa) fasta scores%3B opt: 357%2C z-score: 430.7%2C E(): 1.1e-16%2C (33.8%25 identity in 195 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene3545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3521 SCO3522 SCO3522 SCE2.03c SCE2.03c 3890457 3890792 - transcriptional regulator SCE2.03c%2C possible transcriptional regulator%2C len: 111aa%3B similar to many egs. SW:YW25_MYCTU hypothetical transcriptional regulator from Mycobacterium tuberculosis (118 aa) fasta scores%3B opt: 348%2C z-score: 457.9%2C E(): 3.4e-18%2C (52.9%25 identity in 102 aa overlap) and SW:ARSR_STAXY arsenical ersistance operon repressor from Staphylococcus xylosus plasmid pSX267 (104 aa) fasta scores%3B opt: 126%2C z-score: 176.8%2C E(): 0.016%2C (30.4%25 identity in 102 aa overlap). Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene3546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3522 SCO3523 SCO3523 SCE2.04 SCE2.04 3891104 3891829 + hypothetical protein SCE2.04%2C unknown%2C len: 241aa gene gene3547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3523 SCO3524 SCO3524 SCE2.05 SCE2.05 3891921 3892586 + hypothetical protein SCE2.05%2C unknown%2C len: 221aa gene gene3548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3524 SCO3525 SCO3525 SCE2.06 SCE2.06 3892682 3893122 + hypothetical protein SCE2.06%2C membrane protein%2C len: 146 aa. Contains possible hydrophobic membrane spanning regions gene gene3549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3525 SCO3526 SCO3526 SCE2.07 SCE2.07 3893187 3894470 + hypothetical protein SCE2.07%2C hypothetical protein%2C len: 427 aa%3B C-terminal region similar to TR:Q9L1W2 (EMBL:AL138667) Streptomyces coelicolor hypothetical protein (fragment) SC3D9.17c%2C 235 aa%3B fasta scores: opt: 1120 Z-score: 1250.9 E(): 4.8e-62%3B 71.795%25 identity in 234 aa overlap gene gene3550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3526 SCO3527 SCO3527 SCE2.08 SCE2.08 3894467 3894697 + hypothetical protein SCE2.08%2C unknown%2C len: 76aa gene gene3551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3527 SCO3528 SCO3528 SCE2.09 SCE2.09 3894706 3895866 + hypothetical protein SCE2.09%2C unknown%2C len: 386 aa%3B weak similarity to several predicted helicases e.g. SW:DNAB_TREPA replicative DNA helicase from Treponema pallidum (438 aa) fasta scores%3B opt: 188%2C z-score: 190.6%2C E(): 0.0027%2C (36.5%25 identity in 156 aa overlap) and similar to TR:Q9L1W8 (EMBL:AL138667) Streptomyces coelicolor hypothetical protein SC3D9.11c%2C 372 aa%3B fasta scores: opt: 559 Z-score: 528.6 E(): 8.2e-22%3B 37.466%25 identity in 363 aa overlap gene gene3552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3528 SCO3529 SCO3529 SCE2.10c SCE2.10c 3896197 3896718 - hypothetical protein SCE2.10c%2C unknown%2C len: 173aa gene gene3553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3529 SCO3530 SCO3530 SCE2.11 SCE2.11 3897241 3897840 + hypothetical protein SCE2.11%2C unknown%2C len: 199 aa%3B similar to TR:Q9L1M9 (EMBL:AL138977) Streptomyces coelicolor hypothetical protein SC7F9.38%2C 211 aa%3B fasta scores: opt: 562 Z-score: 634.5 E(): 1e-27%3B 44.444%25 identity in 189 aa overlap gene gene3554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3530 SCO3531 SCO3531 SCE2.12 SCE2.12 3897837 3898616 + hypothetical protein SCE2.12%2C unknown%2C len: 259aa%3B similar to TR:Q9L1M6 (EMBL:AL138977) SC7F9.41 hypothetical protein from Streptomyces coelicolor (246 aa) fasta scores%3B opt: 405%2C Z-score: 481.6%2C E(): 3.4e-19%2C 35.622%25 identity (39.713%25 ungapped) in 233 aa overlap. gene gene3555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3531 SCO3532 SCO3532 SCE2.13 SCE2.13 3898613 3899089 + hypothetical protein SCE2.13%2C unknown%2C len: 158aa gene gene3556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3532 SCO3533 SCO3533 SCE2.14 SCE2.14 3899086 3899751 + hypothetical protein SCE2.14%2C unknown%2C len: 221aa gene gene3557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3533 SCO3534 SCO3534 SCE2.15 SCE2.15 3899823 3902345 + large ATP-binding protein SCE2.15%2C possible large ATP-binding protein%2C len: 840aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and a probable coiled-coil region around 600-650aa. gene gene3558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3534 SCO3535 SCO3535 SCE2.16 SCE2.16 3902381 3904501 + hypothetical protein SCE2.16%2C unknown%2C len: 706aa gene gene3559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3535 SCO3536 SCO3536 SCE2.17 SCE2.17 3904532 3904624 + gene gene3560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3536 SCO3537 SCO3537 SCE2.18c SCE2.18c 3904869 3906041 - DNA-binding protein SCE2.18c%2C possible DNA-binding protein%2C len: 390 aa%3B similar to TR:O53463 (EMBL:AL021899) regulator from Mycobacterium tuberculosis (346 aa) fasta scores%3B opt: 208%2C z-score: 251.9%2C E(): 1e-06%2C (32.8%25 identity in 302 aa overlap). Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. gene gene3561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3537 SCO3538 SCO3538 SCE2.19c SCE2.19c 3906058 3906801 - hypothetical protein SCE2.19c%2C unknown%2C len: 247aa gene gene3562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3538 SCO3539 SCO3539 SCE2.20 SCE2.20 3907269 3908108 + transposase SCH5.01%2C partial CDS%2C possible transposase%2C len: >228aa%3B similar to many eg. TR:Q54404 (EMBL:Z11519) probable transposase from Tn4811 of Streptomyces lividans 66 (320 aa) fasta scores%3B opt: 535%2C z-score: 648.0%2C E(): 8.7e-29%2C (41.0%25 identity in 227 aa overlap)~SCE2.20%2C partial CDS%2C probable transposase%2C len: >84aa%3B almost identical to TR:D1039642 (EMBL:AB024596) transposase from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 596%2C z-score: 817.8%2C E(): 0%2C (98.8%25 identity in 84 aa overlap)%2C note conflicting start codon%2C GTG not ATG. Also similar to many others eg. TR:Q54404 (EMBL:Z11519) from transposable element%2C Tn4811%2C in Streptomyces lividans 66 (320 aa) fasta scores%3B opt: 197%2C z-score: 276.0%2C E(): 4.6e-08%2C (42.9%25 identity in 77 aa overlap). gene gene3563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3539 SCO3540 SCO3540 SCH5.02c SCH5.02c 3908520 3910139 - proteinase SCH5.02c%2C slpD%2C proteinase (hypothetical protein)%2C len: 539 aa%3B identical to the previously sequenced TR:Q54398 (EMBL:L42758) SlpD%2C mycelium-associated (lipoprotein) proteinase from Streptomyces lividans 66 (539 aa) fasta scores%3B opt: 3608%2C z-score: 3750.3%2C E(): 0%2C (100.0%25 identity in 539 aa overlap). Also similar to two other peptidases from Streptomyces coelicolor SC9C7.15c (EMBL:AL035161) fasta scores%3B opt: 666%2C z-score: 603.6%2C E(): 9.4e-29%2C (35.7%25 identity in 502 aa overlap) and SC1B5.03c (EMBL:AL023517) fasta scores%3B opt: 661%2C z-score: 598.9%2C E(): 1.7e-28%2C (32.6%25 identity in 562 aa overlap). Contains probable N-terminal signal sequence. Also contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold%2C score 56.80%2C E-value 4.7e-13. gene gene3565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3540 SCO3541 SCO3541 SCH5.03c SCH5.03c 3910252 3911457 - DNA polymerase III subunit delta' catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand%3B the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA gene gene3566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3541 SCO3542 SCO3542 SCH5.05c SCH5.05c 3911610 3914879 - integral membrane protein with kinase activity SCH5.05c%2C probable integral membrane protein with kinase activity%2C len: 1089 aa%3B a multidomain protein. The N-terminal 480 aa (approx.) contains several probable membrane spanning hydrophobic regions. 510-710 aa similar to several thymidylate kinases e.g. SW:KTHY_ECOLI thymidylate kinase%2C Tmk%2C from Escherichia coli (213 aa) fasta scores%3B opt: 423%2C z-score: 339.7%2C E(): 1.3e-11%2C (38.4%25 identity in 198 aa overlap). 710-800 aa (approx.) glutamic acid-rich region which may form a hinge structure. 800-1089 aa has no distinguishing features or significant database similarities. Further clues to function may be indicated by the presence of matches to PS00217 Sugar transport proteins signature 2 and PS00017 ATP/GTP-binding site motif A (P-loop). Contains Probable coiled-coil from 711 to 875 (165 residues)%2C max score: 2.135%2C (probability 1.00) gene gene3567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3542 SCO3543 SCO3543 SCH5.06c SCH5.06c 3915027 3917885 - DNA topoisomerase I SCH5.06c%2C probable DNA topoisomerase I%2C len: 952 aa%3B high levels of similarity to many e.g. SW:TOP1_MYCTU DNA topoisomerase I from Mycobacterium tuberculosis (900 aa) fasta scores%3B opt: 2586%2C z-score: 2586.7%2C E(): 0%2C (58.6%25 identity in 846 aa overlap). Contains PS00396 Prokaryotic DNA topoisomerase I active site and Pfam match to entry PF01131 Topoisom_bac%2C Prokayotic DNA topoisomerase%2C score 736.60%2C E-value 1.1e-217. Also contains alanine/lysine rich C-terminal region. gene gene3568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3543 SCO3544 SCO3544 SCH5.07c SCH5.07c 3918154 3918552 - hypothetical protein SCH5.07c%2C membrane protein%2C len: 132 aa. Contains possible hydrophobic membrane spanning regions gene gene3569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3544 SCO3545 SCO3545 SCH5.08c SCH5.08c 3918572 3920089 - transferase SCH5.08c%2C possible transferase%2C len: 505 aa%3B limited similarity to many proteins of undefined function e.g. TR:O27384 (EMBL:AE000896) methyltransferase related protein (196 aa) fasta scores%3B opt: 162%2C z-score: 186.2%2C E(): 0.0046%2C (28.9%25 identity in 152 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature gene gene3570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3545 SCO3546 SCO3546 SCH5.09c SCH5.09c 3920177 3920767 - hypothetical protein SCH5.09c%2C possible small lipoprotein%2C len: 196aa%3B Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and probable N-terminal signal sequence. Contains probable coiled-coil from 104 to 141 (38 residues)%2C max score: 1.630%2C (probability 1.00). gene gene3571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3546 SCO3547 SCO3547 hppA hppA 3920987 3923371 - membrane-bound proton-translocating pyrophosphatase pyrophosphate-energized proton pump%3B pyrophosphate-energized inorganic pyrophosphatase%3B H+-PPase%3B can cleave pyrophosphate to two phosphates%3B can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient gene gene3572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3547 SCO3548 SCO3548 SCH5.11c SCH5.11c 3923710 3924141 - anti-sigma factor SCH5.11c%2C probable anti-sigma factor%2C len: 143 aa%3B similar to many e.g. SW:RSBW_BACSU RsbW%2C anti-sigma B factor from Bacillus subtilis (160 aa) fasta scores%3B opt: 153%2C z-score: 198.9%2C E(): 0.00089%2C (28.7%25 identity in 136 aa overlap) and SW:SP22_BACSU SpoIIAB%2C anti-sigma F factor%2C sporulation protein%2C from Bacillus subtilis (146 aa) fasta scores%3B opt: 125%2C z-score: 165.8%2C E(): 0.063%2C (29.2%25 identity in 137 aa overlap). gene gene3573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3548 SCO3549 SCO3549 bldG bldG 3924251 3924592 - anti-sigma factor antagonist SCH5.12c%2C bldG%2C probable anti-sigma factor antagonist%2C len: 113 aa%3B similar to many e.g. SW:RSBV_BACSU RsbV%2C anti-sigma B factor antagonist from Bacillus subtilis (109 aa) fasta scores%3B opt: 255%2C z-score: 341.7%2C E(): 9.9e-12%2C (45.7%25 identity in 94 aa overlap) and SW:SP21_BACSU spoIIAA%2C anti-sigma F factor antagonist (116 aa) fasta scores%3B opt: 179%2C z-score: 244.8%2C E(): 2.5e-06%2C (30.2%25 identity in 96 aa overlap). gene gene3574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3549 SCO3550 SCO3550 SCH5.13 SCH5.13 3924702 3927149 + helicase SCH5.13%2C possible helicase%2C len: 815 aa%3B similar to many e.g. SW:YPRA_BACSU hypothetical helicase from Bacillus subtilis (749 aa) fasta scores%3B opt: 1616%2C z-score: 1799.2%2C E(): 0%2C (37.7%25 identity in 735 aa overlap). Also similar to TR:O06359 (EMBL:Z95436) hypothetical protein from Mycobacterium tuberculosis (771 aa) fasta scores%3B opt: 2550%2C z-score: 2840.4%2C E(): 0%2C (52.5%25 identity in 774 aa overlap). Contains Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain%2C score 35.50%2C E-value 1.2e-06. gene gene3575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3550 SCO3551 SCO3551 SCH5.14c SCH5.14c 3927094 3927786 - membrane spanning protein SCH5.14c%2C possible membrane spanning protein%2C len: 230aa%3B This CDS has been designated based on Hidden-Markoff Model and Frameplot predictions%2C lies in a region of high %25GC DNA and contains a potential membrane spanning hydrophobic region. Glycine rich N-terminal. gene gene3576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3551 SCO3552 SCO3552 SCH5.15c SCH5.15c 3927783 3928235 - hypothetical protein SCH5.15c%2C membrane protein%2C len: 150 aa%3B similar to TR:O69623 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (125 aa) fasta scores%3B opt: 211%2C z-score: 258.8%2C E(): 4.1e-07%2C (39.6%25 identity in 111 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene3577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3552 SCO3553 SCO3553 SCH5.16c SCH5.16c 3928243 3928470 - small membrane protein SCH5.16c%2C small membrane protein%2C len: 75 aa%3B similar to TR:O69624 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (68 aa) fasta scores%3B opt: 129%2C z-score: 191.2%2C E(): 0.0024%2C (40.0%25 identity in 60 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene3578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3553 SCO3554 SCO3554 SCH5.17c SCH5.17c 3928551 3929354 - hypothetical protein SCH5.17c%2C possible integral membrane protein%2C len: 267aa%3B similar to TR:O69625 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (191 aa) fasta scores%3B opt: 324%2C z-score: 329.4%2C E(): 4.9e-11%2C (40.9%25 identity in 154 aa overlap). Contains possible membrane spanning regions. gene gene3579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3554 SCO3555 SCO3555 SCH5.18c SCH5.18c 3929351 3930316 - hypothetical protein SCH5.18c%2C possible integral membrane protein%2C len: 321 aa%3B similar to TR:O69626 (EMBL:AL022121) hypothetical protein (266 aa) fasta scores%3B opt: 335%2C z-score: 348.0%2C E(): 4.5e-12%2C (38.1%25 identity in 247 aa overlap). Contains probable coiled-coil from 227 to 264 (38 residues)%2C max score: 1.545%2C (probability 0.98). gene gene3580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3555 SCO3556 SCO3556 SCH5.19c SCH5.19c 3930322 3931893 - secretory protein SCH5.19c%2C possible secretory protein%2C len: 523 aa%3B similar to many of undefined function eg. TR:O69627 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (352 aa) fasta scores%3B opt: 1287%2C z-score: 1191.3%2C E(): 0%2C (59.8%25 identity in 351 aa overlap) and SW:TRBB_AGRT6 conjugal transfer protein from Agrobacterium tumefaciens (323 aa) fasta scores%3B opt: 469%2C z-score: 441.4%2C E(): 2.8e-17%2C (31.4%25 identity in 287 aa overlap). Contains Pfam match to entry PF00437 GSPII_E%2C Bacterial type II secretion system protein%2C score 41.30%2C E-value 1.6e-11. Also contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00041 Bacterial regulatory proteins%2C araC family signature. gene gene3581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3556 SCO3557 SCO3557 SCH5.20c SCH5.20c 3931899 3933089 - septum site determining protein SCH5.20c%2C possible septum site associated protein%2C len: 396aa%3B similar to many eg. TR:O33612 (EMBL:AB004855) involved in inhibition of morphological differentiation in Streptomyces azureus (260 aa) fasta scores%3B opt: 1510%2C z-score: 1580.5%2C E(): 0%2C (89.1%25 identity in 256 aa overlap) and SW:MIND_BACSU MinD%2C septum site determining protein from Bacillus subtilis (268 aa) fasta scores%3B opt: 177%2C z-score: 193.3%2C E(): 0.0019%2C (22.7%25 identity in 242 aa overlap). gene gene3582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3557 SCO3558 SCO3558 SCH5.21 SCH5.21 3933752 3934558 + morphological differentiation-associated protein SCH5.21%2C probable morphological differentiation-associated protein%2C len: 268 aa%3B almost identical to TR:O33611 (EMBL:AB004855) protein associated with inhibition of morphological differentiation in Streptomyces cyaneus (277 aa) fasta scores%3B opt: 1655%2C z-score: 1949.5%2C E(): 0%2C (93.7%25 identity in 268 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene3583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3558 SCO3559 SCO3559 SCH5.22c SCH5.22c 3934978 3935802 - oxidoreductase SCH5.22c%2C possible oxidoreductase%2C len: 274aa%3B similar to TR:O69630 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (256 aa) fasta scores%3B opt: 289%2C z-score: 335.7%2C E(): 2.1e-11%2C (39.3%25 identity in 270 aa overlap). Also contains a region of similarity to many fatty acid desaturases from plants eg. SW:STAD_RICCO Stearoyl-acyl-carrier-protein desaturase from Ricinus communis (castor bean) (396 aa) fasta scores%3B opt: 112%2C z-score: 133.1%2C E(): 4.1%2C (25.3%25 identity in 146 aa overlap). gene gene3584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3559 SCO3560 SCO3560 SCH5.23 SCH5.23 3935905 3936894 + ATP-binding protein SCH5.23%2C possible ATP-binding protein%2C len: 329aa%3B Contains PS00017 ATP/GTP-binding site motif A (P-loop). Similar to other proposed ATP-binding proteins of undefined function eg. SW:Y823_METJA hypothetical ATP-binding protein from Methanococcus jannashii (257 aa) fasta scores%3B opt: 237%2C z-score: 279.6%2C E(): 2.9e-08%2C (30.5%25 identity in 256 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3560 SCO3561 SCO3561 SCH5.24c SCH5.24c 3936946 3938241 - hypothetical protein SCH5.24c%2C possible lipoprotein%2C len: 431aa%3B Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene3586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3561 SCO3562 SCO3562 SCH5.25 SCH5.25 3938497 3940989 + integral membrane transport protein SCH5.25%2C possible integral membrane transport%2C len: 830aa%3B contains possible membrane spanning hydrophobic regions. C-terminal region (600-800aa) similar to carbonic anhydrases eg. SW:CYNT_ECOLI carbonic anhydrase from Escherichia coli fasta scores%3B opt: 342%2C z-score: 333.5%2C E(): 2.9e-11%2C (35.7%25 identity in 210 aa overlap). Also N-terminal half has weak similarity to several proposed sulphate transporters e.g TR:Q55814 (EMBL:D64004) low affinity sulphate transporter from Synechocystis sp. PCC6803 fasta scores%3B opt: 419%2C z-score: 400.7%2C E(): 5.2e-15%2C (30.0%25 identity in 420 aa overlap). Contains Pfam matches to entry PF00484 Pro_CA%2C Prokaryotic-type carbonic anhydrases%2C score 131.20%2C E-value 5.4e-37 and entry PF00916 Sulfate_transp%2C Sulfate transporter family%2C score 119.90%2C E-value 4.9e-32. gene gene3587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3562 SCO3563 SCO3563 acsA acsA 3941251 3943206 + acetyl-CoA synthetase Acs%3B catalyzes the conversion of acetate and CoA to acetyl-CoA gene gene3588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3563 SCO3564 SCO3564 nhaA nhaA 3943390 3944814 + pH-dependent sodium/proton antiporter exports sodium by using the electrochemical proton gradient to allow protons into the cell%3B functions in adaptation to high salinity and alkaline pH%3B activity increases at higher pH%3B downregulated at acidic pH gene gene3589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3564 SCO3565 SCO3565 SCH5.28 SCH5.28 3944949 3945437 + integral membrane transport protein SCH5.28%2C possible integral membrane transport protein%2C len: 162aa%3B similar to TR:O69637 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (172 aa) fasta scores%3B opt: 265%2C z-score: 318.8%2C E(): 1.9e-10%2C (37.4%25 identity in 155 aa overlap). Also limited similarity to TR:O51582 (EMBL:AE001165) proposed sodium/proton antiporter from Borrelia burgdorferi (449 aa) fasta scores%3B opt: 104%2C z-score: 127.7%2C E(): 8.3%2C (32.5%25 identity in 77 aa overlap) and SW:XYLH_HAEIN proposed xylose transport permease from Haemophilus influenzae (375 aa) blast scores (3-109aa) Identities %3D 33/108 (30%25)%2C Positives %3D 53/108 (49%25)%3B (97-127aa) Identities %3D 9/31 (29%25)%2C Positives %3D 18/31 (58%25). Contains possible membrane spanning hydrophobic regions. gene gene3590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3565 SCO3566 SCO3566 SCH5.29 SCH5.29 3945434 3946408 + hydrolase SCH5.29%2C possible hydrolase%2C len: 324aa%3B similar to many egs. TR:O69638 (EMBL:AL022121) epoxide hydrolase from Mycobacterium tuberculosis (327 aa) fasta scores%3B opt: 687%2C z-score: 786.1%2C E(): 0%2C (40.7%25 identity in 327 aa overlap) and TR:Q39856 (EMBL:D63781) epoxide hydrolase from Glycine max (soybean) (341 aa) fasta scores%3B opt: 396%2C z-score: 455.4%2C E(): 4.6e-18%2C (29.1%25 identity in 316 aa overlap). Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold%2C score 68.70%2C E-value 1.3e-16. gene gene3591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3566 SCO3567 SCO3567 SCH17.01c SCH17.01c 3946803 3948008 - serine protease SCH17.01c%2C probable serine protease%2C partial CDS%2C len: >54 aa%3B continues as SCH5.30c in cosmid H5 (EMBL:AL035636). Alternative start codons are present at codons 3 and 8~SCH5.30c%2C partial CDS%2C probable serine protease%2C len: >385aa%3B similar to many eg. TR:O69639 (EMBL:AL022121) proposed serine protease from Mycobacterium tuberculosis (397 aa) fasta scores%3B opt: 835%2C z-score: 938.4%2C E(): 0%2C (39.9%25 identity in 386 aa overlap) and TR:Q44597 (EMBL:U07352) htrA%2C serine protease from Brucella abortus (513 aa) fasta scores%3B opt: 222%2C z-score: 251.4%2C E(): 1.1e-06%2C (30.6%25 identity in 180 aa overlap). gene gene3592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3567 SCO3568 SCO3568 SCH17.02c SCH17.02c 3948054 3948797 - hypothetical protein SCH17.02c%2C conserved hypothetical protein%2C len: 247 aa%3B similar to hypothetical proteins from several organisms e.g. TR:O69640 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical protein (273 aa)%2C fasta scores%3B opt: 524 z-score: 559.0 E(): 8.3e-24%2C 42.6%25 identity in 251 aa overlap. Similar sequences from other organisms e.g. Escherichia coli%2C Klebsiella aerogenes and Schizosaccharomyces pombe%2C have N-termini divergent from this sequence gene gene3593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3568 SCO3569 SCO3569 SCH17.03c SCH17.03c 3948850 3949602 - endonuclease SCH17.03c%2C probable endonuclease%2C len: 250 aa%3B similar to many e.g. SW:UVEN_MICLU (EMBL:U22181)%2C pdg%2C Micrococcus luteus ultraviolet N-glycosylase/AP lyase (279 aa)%2C fasta scores%3B opt: 1012 z-score: 970.1 E(): 0%2C 61.3%25 identity in 261 aa overlap. Weakly similar to SCE94.06%2C mutY (EMBL:AL049628) S.coelicolor adenine glycosylase (308 aa) (30.3%25 identity in 201 aa overlap)%2C differing at C-terminus. Contains Pfam match to entry PF00730 Endonuclease_3%2C Endonuclease III%2C PS01155 Endonuclease III family signature1 and PS00764 Endonuclease III iron-sulfur binding region signature gene gene3594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3569 SCO3570 SCO3570 SCH17.04 SCH17.04 3949727 3950062 + hypothetical protein SCH17.04%2C possible membrane protein%2C len: 111 aa%3B unknown function%2C probable highly hydrophobic CDS suggested by positional base preference%2C GC frame analysis and a RBS. Sequence is rich in Ala and Phe and contains 8x degenerate (A/V)V(S/F)FA repeats. Contains TTA (leucine) codon%2C possible target for bldA regulation gene gene3595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3570 SCO3571 SCO3571 SCH17.05 SCH17.05 3950326 3951000 + transcriptional regulator SCH17.05%2C probable transcriptional regulator%2C len: 224 aa%3B similar to many%2C especially cAMP-binding receptors%2C e.g. TR:O34015 (EMBL:U87623)%2C Crp%2C Vibrio cholerae cyclic AMP receptor protein (210 aa)%2C fasta scores%3B opt: 314 z-score: 381.1 E(): 6.7e-14%2C 30.6%25 identity in 180 aa overlap. Highly similar to TR:O69644 (EMBL:AL022121) Mycobacterium tuberculosis transcriptional regulator (224 aa) (54.5%25 identity in 224 aa overlap). Contains probable helix-turn-helix motif at aa 176-197 (Score 1923%2C +5.74 SD). Contains Pfam matches to entry PF00027 cNMP_binding%2C Cyclic nucleotide-binding domain and to entry PF00325 crp%2C Bacterial regulatory proteins%2C crp family gene gene3596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3571 SCO3572 SCO3572 SCH17.06c SCH17.06c 3951085 3951855 - hydrolase SCH17.06c%2C possible hydrolase%2C len: 256 aa%3B weakly similar to eukaryotic glyoxalase e.g. SW:GL2M_ARATH (EMBL:U90928)%2C glx2-1%2C Arabidopsis thaliana hydroxyacylglutathione hydrolase (331 aa)%2C fasta scores%3B opt: 186 z-score: 218.1 E(): 8e-05%2C 29.2%25 identity in 161 aa overlap. Similar to many hypothetical proteins e.g. TR:O69645 (EMBL:AL022121) Mycobacterium tuberculosis hydrolase (264 aa) (54.7%25 identity in 247 aa overlap) gene gene3597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3572 SCO3573 SCO3573 SCH17.07c SCH17.07c 3951924 3952862 - hypothetical protein SCH17.07c%2C hypothetical protein%2C len: 312 aa%3B unknown function%2C similar to TR:O53287 (EMBL:AL021287) Mycobacterium tuberculosis hypothetical protein (288 aa)%2C fasta scores%3B opt: 648 z-score: 739.5 E(): 0%2C 50.0%25 identity in 260 aa overlap. Weakly similar to TR:O05487 (EMBL:M93187)%2C TnpA%2C Arthrobacter sp. plasmid pASU1 transposase (229 aa) (25.4%25 identity in 256 aa overlap) gene gene3598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3573 SCO3574 SCO3574 SCH17.08c SCH17.08c 3952921 3953985 - epoxide hydrolase SCH17.08c%2C possible epoxide hydrolase%2C len: 354 aa%3B similar to eukaryotic epoxide hydrolases e.g. TR:Q42566 (EMBL:D16628)%2C atseH%2C Arabidopsis thaliana epoxide hydrolase (321 aa)%2C fasta scores%3B opt: 501 z-score: 542.6 E(): 6.8e-23%2C 37.7%25 identity in 332 aa overlap. Similar to others from S.coelicolor e.g. SCH5.29 (EMBL:AL035636) hydrolase (324 aa) (33.6%25 identity in 348 aa overlap). Alternative start codons are present at codons 6 and 30%2C but these have no apparent RBS. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene3599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3574 SCO3575 SCO3575 SCH17.09c SCH17.09c 3954219 3954686 - hypothetical protein SCH17.09c%2C conserved hypothetical protein%2C len: 155 aa%3B unknown function%2C similar to pB5 (EMBL:U67906) Trypanosoma cruzi protein only expressed in the epimastigote form of the parasite (160 aa)%2C fasta scores%3B opt: 384 z-score: 444.0 E(): 2.1e-17%2C 47.4%25 identity in 152 aa overlap. Also similar to TR:O69646 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical protein (151 aa) (68.0%25 identity in 150 aa overlap) gene gene3600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3575 SCO3576 SCO3576 SCH17.10c SCH17.10c 3954683 3954844 - hypothetical protein SCH17.10c%2C hypothetical protein%2C len: 53 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3576 SCO3577 SCO3577 SCH17.11 SCH17.11 3954997 3955974 + ion-transporting ATPase SCH17.11%2C possible ion-transporting ATPase%2C len: 325 aa%3B similar to N-terminus of TR:O50593 (EMBL:AB004659)%2C arsA%2C ATPase subunit of Acidiphilium multivorum arsenite transport protein (583 aa)%2C fasta scores%3B opt: 204 z-score: 231.6 E(): 1.4e-05%2C 25.8%25 identity in 325 aa overlap. Also similar to TR:O69647 (EMBL:AL022121) Mycobacterium tuberculosis anion transporting ATPase (340 aa) (52.1%25 identity in 328 aa overlap). Part of the N-terminus is weakly similar to the adjacent CDS SCH17.12 (481 aa) (25.9%25 identity in 158 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3577 SCO3578 SCO3578 SCH17.12 SCH17.12 3955971 3957416 + ion-transporting ATPase SCH17.12%2C possible ion-transporting ATPase%2C len: 481 aa%3B similar to many arsenite-translocating ATPases and very weakly to TR:O54984 (EMBL:AF039405)%2C arsA%2C Mus musculus arsenite-translocating ATPase (350 aa)%2C fasta scores%3B opt: 192 z-score: 201.5 E(): 0.00068%2C 21.9%25 identity in 302 aa overlap. Similar to TR:O69648 (EMBL:AL022121) Mycobacterium tuberculosis anion transporting ATPase (386 aa) (51.2%25 identity in 441 aa overlap). Part of the N-terminus is weakly similar to the adjacent CDS SCH17.11 (325 aa) (25.9%25 identity in 158 aa overlap). Contains 3x degenerate PARHQKGX repeats near N-terminus and 3x degenerate SPEASDT repeats near the C-terminus. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3578 SCO3579 SCO3579 SCH17.13c SCH17.13c 3957444 3957782 - regulatory protein SCH17.13c%2C probable transcriptional regulator%2C len: 112 aa%3B similar to many transcriptional regulators from Streptomyces e.g. TR:Q53963 (EMBL:X62287)%2C WhiB%2C S.coelicolor transcriptional regulator essential for sporulation (87 aa)%2C fasta scores%3B opt: 230 z-score: 307.8 E(): 8.1e-10%2C 50.0%25 identity in 64 aa overlap. Highest similarity is to TR:O69649 (EMBL:AL022121) Mycobacterium tuberculosis regulatory protein (100 aa) (67.9%25 identity in 78 aa overlap) gene gene3604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3579 SCO3580 SCO3580 SCH17.14 SCH17.14 3958243 3960513 + transpeptidase SCH66.01%2C partial CDS%2C possible transpeptidase%2C len: >366 aa%3B similar to the C-terminal region of many penicillin-binding transpeptidases eg. SW:PBPD_BACSU penicillin-binding protein 4 from Bacillus subtilis (624 aa) fasta scores%3B opt: 298%2C z-score: 300.3%2C E(): 2.1e-09%2C (32.0%25 identity in 228 aa overlap). Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain%2C score 3.70%2C E-value 1.6e-08.~SCH17.14%2C probable penicillin-binding protein%2C partial CDS%2C len: >427 aa%3B similar to many e.g. TR:P72351 (EMBL:S82044)%2C Pon1%2C Mycobacterium leprae penicillin-binding protein (821 aa)%2C fasta scores%3B opt: 735 z-score: 808.8 E(): 0%2C 36.8%25 identity in 413 aa overlap. Similar to others from S. coelicolor e.g. SCH24.23 (EMBL:AL049826) probable penicillin-binding protein (795 aa) (28.8%25 identity in 420 aa overlap). Contains hydrophobic%2C possible membrane-spanning region in the N-terminus. Contains Pfam match to entry PF00912 Transglycosyl%2C Transglycosylase gene gene3605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3580 SCO3581 SCO3581 SCH66.02c SCH66.02c 3960641 3961105 - hypothetical protein SCH66.02c%2C unknown%2C len: 154aa%3B similar to many eg. TR:O69656 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (154 aa) fasta scores%3B opt: 425%2C z-score: 453.4%2C E(): 6.2e-18%2C (46.1%25 identity in 154 aa overlap). gene gene3606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3581 SCO3582 SCO3582 SCH66.03 SCH66.03 3961226 3962155 + hypothetical protein SCH66.03%2C hypothetical protein%2C len: 309 aa%3B similar to many e.g. TR:O69651 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (319 aa) fasta scores%3B opt: 610%2C z-score: 716.1%2C E(): 1.5e-32%2C (51.5%25 identity in 307 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene3607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3582 SCO3583 SCO3583 SCH66.04 SCH66.04 3962279 3963043 + integral membrane regulator SCH66.04%2C possible integral membrane regulator%2C len: 254 aa%3B C-terminal region highly similar to TR:Q54389 (EMBL:M27108) ORFA located alongside the pSAM2 attachment site in Streptomyces lividans (100 aa) fasta scores%3B opt: 621%2C z-score: 728.0%2C E(): 0%2C (95.0%25 identity in 100 aa overlap). N-terminal region similar to SW:CARR_MYXXA CarR%2C light-induced regulator of carotenogenesis in Myxococcus xanthus (221 aa) fasta scores%3B opt: 120%2C z-score: 148.1%2C E(): 0.63%2C (31.1%25 identity in 167 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene3608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3583 SCO3584 SCO3584 SCH66.05c SCH66.05c 3963217 3963576 - hypothetical protein SCH66.05c%2C unknown%2C len: 119 aa%3B some similarity to TR:O86817 (EMBL:AL031031) very hypothetical protein from Streptomyces coelicolor (88 aa) fasta scores%3B opt: 96%2C z-score: 132.6%2C E(): 4.6%2C (48.4%25 identity in 62 aa overlap). gene gene3610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3584 SCO3585 SCO3585 SCH66.06 SCH66.06 3963717 3964058 + hypothetical protein SCH66.06%2C unknown%2C len: 113aa gene gene3611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3585 SCO3586 SCO3586 SCH66.07c SCH66.07c 3964141 3965133 - hypothetical protein SCH66.07c%2C possible integral membrane protein%2C len: 330aa%3B contains a possible membrane spanning hydrophobic region gene gene3612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3586 SCO3587 SCO3587 SCH66.08c SCH66.08c 3965144 3965737 - regulatory protein SCH66.08c%2C possible regulatory protein%2C len: 197 aa%3B similar to many e.g. TR:CAB37593 (EMBL:AL035569) transcriptional regulator from Streptomyces coelicolor (196 aa) fasta scores%3B opt: 386%2C z-score: 483.1%2C E(): 1.4e-19%2C (35.5%25 identity in 169 aa overlap) and SW:MTRR_NEIGO MtrR regulatory protein from Neisseria gonorrhoeae (210 aa) fasta scores%3B opt: 109%2C z-score: 143.8%2C E(): 1.1%2C (23.3%25 identity in 176 aa overlap). Contains possible helix-turn-helix (+2.97 SD) 26-47 aa. gene gene3613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3587 SCO3588 SCO3588 SCH66.09 SCH66.09 3965649 3966812 + hypothetical protein SCH66.09%2C unknown%2C len: 387 aa%3B similar to TR:O32505 (EMBL:AB003475) hypothetical protein from Deinococcus radiodurans (383 aa) fasta scores%3B opt: 157%2C z-score: 184.7%2C E(): 0.0058%2C (27.1%25 identity in 225 aa overlap). gene gene3614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3588 SCO3589 SCO3589 SCH66.10c SCH66.10c 3966835 3967929 - two component sensor kinase SCH66.10c%2C probable two component sensor kinase%2C len: 364 aa%3B similar to many e.g. SW:CUTS_STRCO two component sensor kinase involved in the regulation of copper uptake in Streptomyces coelicolor (414 aa) fasta scores%3B opt: 659%2C z-score: 768.1%2C E(): 0%2C (35.6%25 identity in 390 aa overlap). Contains Pfam matches to entry PF00512 signal%2C Signal carboxyl-terminal domain and to entry PF00672 DUF5%2C Domain found in bacterial signal proteins. Contains possible hydrophobic membrane spanning regions gene gene3615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3589 SCO3590 SCO3590 SC66T3.01c SC66T3.01c 3967922 3968617 - two-component system response regulator SC66T3.01c%2C probable two-component system response regulator%2C partial CDS%2C len: >62 aa%3B similar to many e.g. SW:CUTR_STRCO (EMBL:X58793)%2C CutR%2C S.coelicolor two component response regulator involved in regulation of copper metabolism (217 aa)%2C fasta scores%3B opt: 231 z-score: 316.5 E(): 2.7e-10%2C 56.5%25 identity in 62 aa overlap. The CDS continues as SCH66.11c in cosmid H66 (EMBL:AL049731)~SCH66.11c%2C probable two component response regulator%2C len: 213 aa%3B similar to many e.g. SW:CUTR_STRCO two component response regulator involved in regulation of copper uptake in Streptomyces coelicolor (217 aa) fasta scores%3B opt: 751%2C z-score: 874.8%2C E(): 0%2C (57.8%25 identity in 199 aa overlap). Contains Pfam matches to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal and to entry PF00072 response_reg%2C Response regulator receiver domain. gene gene3616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3590 SCO3591 SCO3591 SC66T3.02c SC66T3.02c 3968694 3968819 - small membrane protein SC66T3.02c%2C small membrane protein%2C len: 41 aa%3B unknown function%2C improbable CDS suggested by GC frame plot%2C amino acid composition and possible RBS. Contains possible hydrophobic membrane spanning region gene gene3617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3591 SCO3592 SCO3592 SC66T3.03 SC66T3.03 3968822 3969814 + hypothetical protein SC66T3.03%2C possible membrane protein%2C len: 330 aa%3B similar to TR:Q9L038 (EMBL:AL352956) Streptomyces coelicolor membrane protein SC1H10.06c%2C 301 aa%3B fasta scores: opt: 557 Z-score: 630.1 E(): 1.8e-27%3B 50.968%25 identity in 310 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions at the N-terminus region gene gene3618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3592 SCO3593 SCO3593 SC66T3.04 SC66T3.04 3970005 3971198 + hypothetical protein SC66T3.04%2C hypothetical protein%2C len: 397 aa%3B unknown function%2C weakly similar to many femA proteins e.g. SW:FEMA_STAAU (EMBL:M23918)%2C FemA%2C Staphylococcus aureus factor essential for expression of methicillin resistance (433 aa)%2C fasta scores%3B opt: 184 z-score: 218.4 E(): 7.7e-05%2C 23.3%25 identity in 434 aa overlap. Similar to SCH24.26c (EMBL:AL049826) S.coelicolor hypothetical protein (373 aa) (50.4%25 identity in 387 aa overlap) gene gene3619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3593 SCO3594 SCO3594 dldh dldh 3971293 3972306 + D-lactate dehydrogenase SC66T3.05%2C dldh%2C probable D-lactate dehydrogenase%2C len: 337 aa%3B highly similar to many e.g. TR:O33805 (EMBL:U8296) Streptomyces toyocaensis D-lactate dehydrogenase (330 aa)%2C fasta scores%3B opt: 1470 z-score: 1711.8 E(): 0%2C71.4%25 identity in 318 aa overlap. Also similar to D-specific alpha-keto acid dehydrogenases from vancomycin-resistant bacteria e.g. SW:VANH_ENTFC (EMBL:M64304)%2C VanH%2C Enterococcus faecium alpha-keto acid dehydrogenase (322 aa) (61.4%25 identity in 316 aa overlap). Similar to other S.coelicolor dehydrogenases e.g. part of SerA (EMBL:AL035569) S.coelicolor probable D-3-phosphoglycerate dehydrogenase (529 aa) (32.2%25 identity in 255 aa overlap). Contains Pfam matches to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases%2C PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2 and PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3 gene gene3620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3594 SCO3595 SCO3595 vanB vanB 3972317 3973357 + D-alanine--D-lactate ligase vancomycin B-type resistance protein%3B catalyzes the formation of D-alanyl-D-lactate in peptidoglycan synthesis gene gene3621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3595 SCO3596 SCO3596 SC66T3.07 SC66T3.07 3973354 3973962 + D-alanine:D-alanine dipeptidase SC66T3.07%2C probable D-alanine:D-alanine dipeptidase%2C len: 202 aa%3B highly similar to e.g. vanXst (EMBL:AF039028) Streptomyces toyocaensis D-ala-D-ala dipeptidase (208 aa)%2C fasta scores%3B opt: 1137 z-score: 1354.4 E(): 0%2C 77.6%25 identity in 201 aa overlap. Also similar to e.g. SW:VANX_ENTF (EMBL:U35369)%2C vanXB%2C Enterococcus faecalis D-alanyl-D-alanine dipeptidase (202 aa) (63.9%25 identity in 202 aa overlap) gene gene3622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3596 SCO3597 SCO3597 SC66T3.08c SC66T3.08c 3974012 3974824 - hypothetical protein SC66T3.08c%2C conserved hypothetical protein%2C len: 270 aa%3B unknown function%2C similar to hypothetical proteins from Mycobacterium tuberculosis%2C Mycobacterium leprae and Bacillus subtilis e.g. SW:Y03O_MYCTU (EMBL:Z75555) Mycobacterium tuberculosis hypothetical protein (273 aa)%2C fasta scores%3B opt: 413 z-score: 428.5 E(): 1.5e-16%2C 31.7%25 identity in 268 aa overlap. Contains poly-glycine tract at N-terminus which is absent in the similar sequences gene gene3623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3597 SCO3598 SCO3598 SC66T3.09c SC66T3.09c 3974836 3975600 - hypothetical protein SC66T3.09c%2C possible membrane protein%2C len: 254 aa%3B unknown function%2C similar to TR:O26720 (EMBL:AE000843) Methanobacterium thermoautotrophicum hypothetical protein%2C fasta scores%3B opt: 319 z-score: 383.6 E(): 4.9e-14%2C 28.7%25 identity in 251 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene3624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3598 SCO3599 SCO3599 SC66T3.10c SC66T3.10c 3975852 3976808 - hypothetical protein SC66T3.10c%2C hypothetical protein%2C len: 318 aa%3B unknown function%2C similar to hypothetical proteins e.g. TR:O54025 (EMBL:AJ000884)%2C ORF2%2C Paracoccus denitrificans hypothetical protein (281 aa)%2C fasta scores%3B opt: 244 z-score: 272.8 E(): 7.2e-08%2C 31.5%25 identity in 295 aa overlap gene gene3625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3599 SCO3600 SCO3600 SC66T3.11 SC66T3.11 3976909 3977412 + hypothetical protein SC66T3.11%2C hypothetical protein%2C len: 167 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. The start codon is uncertain%3B two possible starts codons are present 12 and 15 codons upstream gene gene3626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3600 SCO3601 SCO3601 SC66T3.12 SC66T3.12 3977529 3978014 + hypothetical protein SC66T3.12%2C conserved hypothetical protein%2C len: 161 aa%3B unknown function%2C similar to hypothetical proteins from several organisms%2C often adjacent to a ion transport protein e.g. TR:O05882 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical protein (160 aa)%2C fasta scores%3B opt: 348 z-score: 435.7 E(): 6.1e-17%2C 44.1%25 identity in 152 aa overlap. Similar to TR:O69959 (EMBL:AL022268) S.coelicolor hypothetical protein (161 aa) (68.9%25 identity in 161 aa overlap)%2C which is also adjacent to a possible ion transport protein gene gene3627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3601 SCO3602 SCO3602 SC66T3.13c SC66T3.13c 3978061 3979272 - transmembrane transport protein SC66T3.13c%2C probable transmembrane transport protein%2C len: 403 aa%3B similar to many ion transport proteins and to part of SW:KEFC_ECOLI (EMBL:X56742)%2C kefC%2C Escherichia coli glutathione-regulated potassium-efflux system protein (620 aa)%2C fasta scores%3B opt: 328 z-score: 319.2 E(): 1.9e-10%2C 27.1%25 identity in 410 aa overlap. Similar to TR:O69958 (EMBL:AL022268) S.coelicolor transmembrane transport protein (411 aa) (74.9%25 identity in 399 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions gene gene3628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3602 SCO3603 SCO3603 cvrA cvrA 3979806 3981350 - potassium/proton antiporter the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter%3B can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli gene gene3629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3603 SCO3604 SCO3604 SC66T3.15c SC66T3.15c 3981549 3981839 - hypothetical protein SC66T3.15c%2C possible membrane protein%2C len: 96 aa%3B unknown function%2C N-terminus similar to TR:O53503 (EMBL:L021957) Mycobacterium tuberculosis hypothetical protein (134 aa)%2C fasta scores%3B opt: 134 z-score: 179.9 E(): 0.011%2C 34.7%25 identity in 101 aa overlap and TR:O69562 (EMBL:AL022602) Mycobacterium leprae hypothetical protein (134 aa) (38.3%25 identity in 60 aa overlap). Contains central hydrophobic region while the remainder is hydrophilic gene gene3630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3604 SCO3605 SCO3605 SC66T3.16 SC66T3.16 3982106 3982402 + hypothetical protein SC66T3.16%2C hypothetical protein%2C len: 98 aa%3B unknown function%2C probable CDS suggested by positional base preference and GC frame analysis. C-terminus is Asn-rich and contains 2x QQPY repeats gene gene3631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3605 SCO3606 SCO3606 SC66T3.17 SC66T3.17 3982525 3983607 + regulator SC66T3.17%2C possible regulator%2C len: 360 aa%3B similar to the C-terminal region of TR:Q00509 (EMBL:X63451)%2C SrmR%2C Streptomyces ambofaciens polyketide synthase regulatory gene (604 aa)%2C fasta scores%3B opt: 248 z-score: 291.7 E(): 6.4e-09%2C 25.3%25 identity in 372 aa overlap. Also similar to the C-terminal region of Mycobacteria e.g. TR:O69477 (EMBL:AL023635) Mycobacterium leprae hypothetical protein (414 aa) (26.0%25 identity in 277 aa overlap). Weakly similar to the C-terminal region of SC8D9.30c (EMBL:AL035569) S.coelicolor possible transcriptional regulator (415 aa) (26.7%25 identity in 303 aa overlap). Contains probable helix-turn-helix motif at aa 237-258 (score 1012%2C +2.63 SD) gene gene3632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3606 SCO3607 SCO3607 SC66T3.18c SC66T3.18c 3983677 3985146 - hypothetical protein SC66T3.18c%2C possible hypothetical protein%2C len: 489 aa%3B unknown function%2C similar to SW:YUAG_BACSU (EMBL:Z99119) Bacillus subtilis hypothetical protein (509 aa)%2C fasta scores%3B opt: 618 z-score: 592.7 E(): 1.1e-25%2C 36.8%25 identity in 503 aa overlap. Also similar to many eukaryotic flotillins (epidermal surface antigens) e.g. TR:O75955 (EMBL:AF089750) Homo sapiens flotillin-1 (427 aa) (34.8%25 identity in 442 aa overlap). N-terminus is hydrophobic and may contitute a membrane anchor. Contains probable coiled-coil from 205 to 258 (54 residues) (Max score: 1.522%2C probability 0.97) and possible N-terminal region signal sequence peptide gene gene3633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3607 SCO3608 SCO3608 SC66T3.19c SC66T3.19c 3985241 3985750 - hypothetical protein SC66T3.19c%2C hypothetical protein%2C len: 169 aa%3B unknown function%2C weakly similar to TR:O32077 (EMBL:Z99119)%2C YuaF%2C Bacillus subtilis hypothetical protein (174 aa)%2C fasta scores%3B opt: 142 z-score: 164.3 E(): 0.08%2C 28.0%25 identity in 161 aa overlap. Contains 5x (V/L)(F/L)(D/E)G repeats near the N-terminus gene gene3634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3608 SCO3609 SCO3609 SC66T3.20 SC66T3.20 3985984 3987855 + hypothetical protein SC66T3.20%2C possible membrane protein%2C len: 623 aa%3B unknown function%2C C-terminus shares weak similarity with other hypothetical membrane proteins e.g. TR:P74405 (EMBL:D90914) Synechocystis sp. hypothetical protein (568 aa)%2C fasta scores%3B opt: 250 z-score: 272.0 E(): 8e-08%2C 24.3%25 identity in 576 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene3635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3609 SCO3610 SCO3610 SC66T3.21c SC66T3.21c 3988036 3989856 - peptide hydrolase SC66T3.21c%2C probable peptide hydrolase%2C len: 606 aa%3B similar to many peptidases e.g. (EMBL:AB01029) Sphingomonas capsulata prolyl oligopeptidase (723 aa)%2C fasta scores%3B opt: 333 z-score: 359.1 E(): 1.1e-12%2C 25.8%25 identity in 620 aa overlap (dissimilar at N-terminus). Also weakly similar to eukaryotic peptidases e.g. TR:P70479 (EMBL:X14915) Rattus norvegicus acyl-peptide hydrolase (729 aa) (26.6%25 identity in 395 aa overlap). Contains Pfam match to entry PF00326 Prolyl_oligopep%2C Prolyl oligopeptidase family gene gene3636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3610 SCO3611 SCO3611 SC66T3.22 SC66T3.22 3989980 3990816 + hypothetical protein SC66T3.22%2C membrane protein%2C len: 278 aa%3B unknown function%2C weakly similar to SW:Y01G_MYCTU (EMBL:Z70692) Mycobacterium tuberculosis hypothetical protein (271 aa)%2C fasta scores%3B opt: 218 z-score: 233.1 E(): 1.2e-05%2C 26.8%25 identity in 254 aa overlap. Has a hydrophobic region at the N-terminus gene gene3637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3611 SCO3612 SCO3612 SC66T3.23c SC66T3.23c 3990912 3992276 - hypothetical protein SC66T3.23c%2C possible membrane protein%2C len: 454 aa%3B unknown function%2C the N-terminal third of the protein is hydrophilic%2C followed by a hydrophobic%2C possible membrane-spanning region. The N-terminus also contains 7x slightly degenerate HD(P/A)G(S/P/A)(D/G)ARDG repeats gene gene3638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3612 SCO3613 SCO3613 SC66T3.24c SC66T3.24c 3992273 3992845 - RNA polymerase sigma factor SC66T3.24c%2C possible RNA polymerase sigma factor%2C len: 190 aa%3B weakly similar to many e.g. SW:RPOE_STRCO (EMBL:L29636)%2C AigE%2C S.coelicolor RNA polymerase sigma-E factor (176 aa)%2C fasta scores%3B opt: 236 z-score: 274.0 E(): 6.1e-08%2C 30.9%25 identity in 162 aa overlap. The start site is uncertain as there is a second possible start site at codon 7 gene gene3639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3613 SCO3614 SCO3614 asd2 asd2 3993330 3994418 - aspartate-semialdehyde dehydrogenase SC66T3.25c%2C asd2%2C probable aspartate-semialdehyde dehydrogenase%2C len: 362 aa%3B highly similar to many e.g. SW:DHAS_CORFL (EMBL:L16848)%2C Asd%2C Corynebacterium flavum aspartate-semialdehyde dehydrogenase (344 aa)%2C fasta scores%3B opt: 1018 z-score: 1179.9 E(): 0%2C 50.9%25 identity in 348 aa overlap. The start site is uncertain as the GC frame plot suggests that the start may be at codon 22. Contains Pfam match to entry PF01118 Semialdhyde_dh%2C Semialdehyde dehydrogenase gene gene3640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3614 SCO3615 SCO3615 ask ask 3994418 3995695 - aspartate kinase catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP%2C in Bacillus%2C lysine sensitive%3B regulated by response to starvation. gene gene3641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3615 SCO3616 SCO3616 SC66T3.27 SC66T3.27 3995973 3996191 + hypothetical protein SC66T3.27%2C hypothetical protein%2C len: 72 aa%3B unknown function%2C possible CDS suggested by positional base preference and GC frame analysis gene gene3642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3616 SCO3617 SCO3617 SC66T3.28c SC66T3.28c 3996276 3996935 - hypothetical protein SC66T3.28c%2C hypothetical protein%2C len: 219 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3617 SCO3618 SCO3618 recR recR 3996928 3997527 - recombination protein RecR involved in a recombinational process of DNA repair%2C independent of the recBC complex gene gene3644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3618 SCO3619 SCO3619 SC66T3.30c SC66T3.30c 3997626 3997973 - hypothetical protein SC66T3.30c%2C hypothetical protein%2C len: 115 aa%3B unknown function%2C similar to other hypothetical proteins with Asn-rich N-termini found in the recR regions of some organisms (e.g. Bacillus subtilis%2C Mycobacterium leprae%2C Mycobacterium tuberculosis%2C Escherichia coli) e.g. TR:O69683 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical protein (113 aa)%2C fasta scores%3B opt: 375 z-score: 409.0 E(): 1.9e-15%2C 50.8%25 identity in 120 aa overlap. Contains probable coiled-coils from 9 to 41 (33 residues) (Max score: 1.832%2C probability 1.00) and from 68 to 96 (29 residues) (Max score: 1.491%2C probability 0.94) gene gene3645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3619 SCO3620 SCO3620 SC66T3.31 SC66T3.31 3998255 3999019 + hypothetical protein SC66T3.31%2C possible membrane protein%2C len: 254 aa%3B unknown function%2C contains hyrophobic%2C possible membrane-spanning region gene gene3646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3620 SCO3621 SCO3621 SC66T3.32c SC66T3.32c 3999086 4001437 - serine-threonine protein kinase SC66T3.32c%2C probable serine-threonine protein kinase%2C len: 783 aa%3B N-terminal half similar to the corresponding region of several serine-threonine protein kinases e.g. SW:AFSK_STRCO (EMBL:D15062)%2C afsK%2C S.coelicolor serine-threonine protein kinase (799 aa)%2C fasta scores%3B opt: 944 z-score: 519.3 E(): 1.3e-21%2C 45.6%25 identity in 379 aa overlap. The central region contains 26x slightly degenerate GG(A/V)G(P/S) repeats. Contains two Pfam matches to entry PF00069 pkinase%2C Eukaryotic protein kinase domain%2C PS00108 Ser/Thr protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature and possible hydrophobic membrane spanning region at the C-terminal domain gene gene3647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3621 SCO3622 SCO3622 SC66T3.33 SC66T3.33 4001665 4003020 + hypothetical protein SC66T3.33%2C probable aminotransferase%2C len: 451 aa%3B similar to many e.g. SW:GABT_ECOLI (EMBL:M88334)%2C gabT%2C Escherichia coli 4-aminobutyrate aminotransferase (426 aa)%2C fasta scores%3B opt: 706 z-score: 815.4 E(): 0%2C 32.3%25 identity in 427 aa overlap. Also similar to TR:O86744 (EMBL:AL031035) S.coelicolor probable aminotransferase (457 aa) (37.3%25 identity in 362 aa overlap). Contains Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate and PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site gene gene3648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3622 SCO3623 SCO3623 SC66T3.34 SC66T3.34 4003147 4003848 + transcriptional regulator SCH10.01%2C hypothetical protein%2C partial CDS%2C len: >119 aa%3B probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition~SC66T3.34%2C probable gntR-family transcriptional regulator%2C partial CDS%2C len: >128 aa%3B similar to many e.g. (EMBL:U91412)%2C luxZ%2C Photobacterium leiognathi lux operon enhancer (221 aa)%2C fasta scores%3B opt: 197 z-score: 240.2 E(): 4.7e-06%2C 32.2%25 identity in 87 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene3649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3623 SCO3624 SCO3624 SCH10.02 SCH10.02 4003950 4004615 + hypothetical protein SCH10.02%2C hypothetical protein%2C len: 221 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3624 SCO3625 SCO3625 SCH10.03c SCH10.03c 4004631 4004921 - hypothetical protein SCH10.03c%2C hypothetical protein%2C len: 96 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3625 SCO3626 SCO3626 SCH10.04c SCH10.04c 4004960 4005844 - RNA polymerase sigma factor SCH10.04c%2C probable RNA polymerase sigma factor%2C len: 294 aa%3B similar to many e.g. TR:O05735 (EMBL:U87308) SigE%2C Mycobacterium avium extracytoplasmic function alternative sigma factor (251 aa)%2C fasta scores%3B opt: 226 z-score: 266.2 E(): 1.6e-07%2C 29.8%25 identity in 168 aa overlap gene gene3652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3626 SCO3627 SCO3627 SCH10.05c SCH10.05c 4005960 4006160 - hypothetical protein SCH10.05c%2C hypothetical protein%2C len: 66 aa%3B unknown function%2C probable CDS suggested by positional base preference and GC frame analysis gene gene3653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3627 SCO3628 SCO3628 SCH10.06c SCH10.06c 4006237 4006728 - hypothetical protein SCH10.06c%2C hypothetical protein%2C len: 163 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains possible N-terminal region signal peptide sequence gene gene3654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3628 SCO3629 SCO3629 purA purA 4006900 4008183 - adenylosuccinate synthetase catalyzes the formation of N6-(1%2C2%2C-dicarboxyethyl)-AMP from L-aspartate%2C inosine monophosphate and GTP in AMP biosynthesis gene gene3655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3629 SCO3630 SCO3630 SCH10.08 SCH10.08 4008369 4009274 + hypothetical protein SCH10.08%2C hypothetical protein%2C len: 301 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains a hydrophobic%2C possible membrane-spanning region gene gene3656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3630 SCO3631 SCO3631 SCH10.09 SCH10.09 4009271 4009780 + hypothetical protein SCH10.09%2C hypothetical protein%2C len: 169 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3631 SCO3632 SCO3632 SCH10.10c SCH10.10c 4009793 4010251 - hypothetical protein SCH10.10c%2C hypothetical protein%2C len: 152 aa%3B unknown function%2C weakly similar to TR:O53786 (EMBL:AL021943) Mycobacterium tuberculosis hypothetical protein (165 aa)%2C fasta scores%3B opt: 151 z-score: 200.3 E(): 0.00078%2C 22.5%25 identity in 142 aa overlap. Contains probable helix-turn-helix motif at aa 37-58 (Score 982%2C +2.53 SD) gene gene3658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3632 SCO3633 SCO3633 SCH10.11 SCH10.11 4010391 4011326 + ABC transporter ATP-binding protein SCH10.11%2C probable ABC transporter ATP-binding protein%2C len: 311 aa%3B similar to many e.g. TR:Q54406 (EMBL:X73633)%2C tnrB2%2C from Streptomyces longisporoflavus%2C which is a component of an ABC transport system which confers resistance to the polyether-ionophore antibiotic tetronasin (300 aa)%2C fasta scores%3B opt: 1323 z-score: 1477.2 E(): 0%2C 67.5%25 identity in 305 aa overlap. Also similar to TR:O86311 (EMBL:Z93777) M.tuberculosis hypothetical protein (311 aa) (63.0%25 identity in 305 aa overlap). Similar to many ABC transporter ATP-binding proteins from Streptomyces coelicolor e.g. SCD78.23 (EMBL:AL034355) ABC transporter ATP-binding protein (320 aa) (34.9%25 identity in 258 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C score 169.60%2C E-value 5.4e-47%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3633 SCO3634 SCO3634 SCH10.12 SCH10.12 4011323 4012942 + ABC transporter membrane-spanning protein SCH10.12%2C possible ABC transporter membrane-spanning protein%2C len: 539 aa%3B similar to TR:Q54407 (EMBL:X73633)%2C tnrB3%2C from Streptomyces longisporoflavus%2C which is a component of an ABC transport system which confers resistance to the polyether-ionophore antibiotic tetronasin (337 aa)%2C fasta scores%3B opt: 1086 z-score: 933.6 E(): 0%2C 35.6%25 identity in 531 aa overla. Also similar to TR:O05318 (EMBL:Z93777) Mycobacterium tuberculosis hypothetical protein (548 aa) (40.9%25 identity in 550 aa overlap). Contains hydrophobic%2C probable membrane-spanning regions. Weakly similar to SC4B5.03c (EMBL:AL034443) Streptomyces coelicolor probable integral membrane efflux protein (504 aa) (26.8%25 identity in 373 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene3660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3634 SCO3635 SCO3635 SCH10.13c SCH10.13c 4013295 4013696 - hypothetical protein SCH10.13c%2C hypothetical protein%2C len: 133 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3635 SCO3636 SCO3636 SCH10.14c SCH10.14c 4013901 4015136 - cytochrome P-450 hydroxylase SCH10.14c%2C probable cytochrome P-450 hydroxylase%2C len: 411 aa%3B similar to many e.g. SW:CPXJ_SACER (EMBL:X60379)%2C EryF%2C Saccharopolyspora erythraea 6-deoxyerythronolide B hydroxylase (404 aa)%2C fasta scores%3B opt: 920 z-score: 1001.6 E(): 0%2C 39.2%25 identity in 406 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450%2C score 174.40%2C E-value 1.9e-48 and PS00086 Cytochrome P450 cysteine heme-iron ligand signature gene gene3662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3636 SCO3637 SCO3637 SCH10.15 SCH10.15 4015264 4015701 + hypothetical protein SCH10.15%2C membrane protein%2C len: 145 aa%3B unknown function%2C probable CDS suggested by positional base preference and GC frame analysis. N-terminal half is hydrophobic%2C while remainder is hydrophilic. Contains possible hydrophobic membrane spanning regions gene gene3663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3637 SCO3638 SCO3638 SCH10.16c SCH10.16c 4015726 4016391 - two-component system regulator SCH10.16c%2C probable two-component system regulator%2C len: 221 aa%3B similar to many e.g. TR:Q53894 (EMBL:U51332)%2C AbsA2%2C Streptomyces coelicolor two-component system regulator homolog involved in negative regulation of antibiotic synthesis (222 aa)%2C fasta scores%3B opt: 610 z-score: 722.5 E(): 6.2e-33%2C 48.1%25 identity in 216 aa overlap. Similar to many other two-component system regulators from Streptomyces coelicolor e.g. SCH10.18c%2C probable two-component regulator (218 aa) (76.1%25 identity in 218 aa overlap). Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 118.30%2C E-value 1.5e-31 and entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 73.00%2C E-value 6.4e-18. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains probable helix-turn-helix motif at aa 174-195 (Score 1032%2C +2.70 SD) gene gene3664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3638 SCO3639 SCO3639 SCH10.17c SCH10.17c 4016388 4017806 - two-component system sensor kinase SCH10.17c%2C probable two-component system sensor kinase%2C len: 472 aa%3B similar to many e.g. TR:Q53893 (EMBL:U51332)%2C AbsA1%2C Streptomyces coelicolor histidine kinase homolog involved in negative regulation of antibiotic synthesis (571 aa)%2C fasta scores%3B opt: 370 z-score: 410.4 E(): 1.5e-15%2C 29.6%25 identity in 375 aa overlap. Also similar to SW:NARX_ECOLI (EMBL:X13360)%2C NarX%2C NarR%2C Escherichia coli nitrate/nitrite sensor protein (598 aa) (28.5%25 identity in 228 aa overlap). Contains hydrophobic%2C probable membrane-spanning regions. Similar to many other two-component system sensor kinases from Streptomyces coelicolor e.g. SCH10.32c%2C probable two-component system sensor (441 aa) (38.0%25 identity in 389 aa overlap). Contains probable helix-turn-helix motif at aa 235-256 (Score 1122%2C +3.01 SD). The start codon may be further downstream%2C which would agree with some other bacterial two-component system sensors%3B however%2C NarX has a length comparable to this prediction gene gene3665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3639 SCO3640 SCO3640 SCH10.18c SCH10.18c 4017820 4018506 - two-component system regulator SCH10.18c%2C probable two-component system regulator%2C len: 228 aa%3B similar to many e.g. TR:Q53894 (EMBL:U51332)%2C AbsA2%2C Streptomyces coelicolor two-component system regulator homolog involved in negative regulation of antibiotic synthesis (222 aa)%2C fasta scores%3B opt: 616 z-score: 718.4 E(): 1.1e-32%2C 46.6%25 identity in 219 aa overlap. Similar to many other two-component system regulators from Streptomyces coelicolor e.g. SCH10.16c%2C probable two-component regulator (221 aa) (76.1%25 identity in 218 aa overlap). Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 118.10%2C E-value 1.7e-31 and ntry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 81.60%2C E-value 1.6e-20. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature. gene gene3666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3640 SCO3641 SCO3641 SCH10.19c SCH10.19c 4018503 4019882 - two-component system sensor kinase SCH10.19c%2C probable two-component system sensor kinase%2C len: 459 aa%3B similar to many e.g. TR:Q53893 (EMBL:U51332)%2C AbsA1%2C Streptomyces coelicolor histidine kinase homolog involved in negative regulation of antibiotic synthesis (571 aa)%2C fasta scores%3B opt: 332 z-score: 342.7 E(): 8.9e-12%2C 30.6%25 identity in 402 aa overlap. Contains hydrophobic%2C probable membrane-spanning regions. Similar to many other two-component system sensor kinases from Streptomyces coelicolor e.g. TR:O86631 (EMBL:AL031155) SC3A7.30%2C probable two-component system sensor (429 aa) (36.2%25 identity in 409 aa overlap). Contains probable coiled-coil from 264 to 292 (29 residues) (Max score: 1.426%2C probability 0.81). The start codon may be further downstream%2C which would agree with some other bacterial two-component system sensors%3B however%2C nitrate/nitrite sensory proteins have a length comparable to this prediction gene gene3667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3641 SCO3642 SCO3642 SCH10.20c SCH10.20c 4019875 4021137 - hypothetical protein SCH10.20c%2C hypothetical membrane protein%2C len: 420 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains several hydrophobic%2C probable membrane-spanning regions. Contains PS00133 Zinc carboxypeptidases%2C zinc-binding region 2 signature gene gene3668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3642 SCO3643 SCO3643 SCH10.21c SCH10.21c 4021130 4022119 - hypothetical protein SCH10.21c%2C hypothetical protein%2C len: 329 aa%3B unknown function%2C weakly similar to SW:YT11_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis hypothetical protein (266 aa)%2C fasta scores%3B opt: 183 z-score: 199.4 E(): 0.00086%2C 30.7%25 identity in 225 aa overlap gene gene3669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3643 SCO3644 SCO3644 SCH10.22c SCH10.22c 4022264 4023169 - lipase/esterase SCH10.22c%2C possible lipase/esterase%2C len: 301 aa%3B weakly similar to many esterases e.g. SW:EST1_CAEEL (EMBL:M96145) Caenorhabditis elegans gut esterase precursor (562 aa)%2C fasta scores%3B opt: 150 z-score: 166.4 E(): 0.059%2C 29.3%25 identity in 280 aa overlap. Contains PS00120 Lipases%2C serine active site gene gene3670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3644 SCO3645 SCO3645 SCH10.23c SCH10.23c 4023366 4024598 - hydrolase SCH10.23c%2C probable hydrolase%2C len: 410 aa%3B similar to e.g. SW:KYNU_RAT (EMBL:U68168) Rattus norvegicus L-kynurenine hydrolase (464 aa)%2C fasta scores%3B opt: 458 z-score: 408.3 E(): 2e-15%2C 27.9%25 identity in 462 aa overlap gene gene3671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3645 SCO3646 SCO3646 SCH10.24c SCH10.24c 4024591 4025406 - oxidoreductase SCH10.24c%2C probable oxidoreductase%2C len: 271 aa%3B weakly similar to tryptophan oxygenases e.g. TR:O77457 (EMBL:L76433) Anopheles gambiae tryptophan oxygenase (392 aa)%2C fasta scores%3B opt: 184 z-score: 222.0 E(): 4.7e-05%2C 24.9%25 identity in 341 aa overlap gene gene3672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3646 SCO3647 SCO3647 SCH10.25c SCH10.25c 4025550 4025981 - hypothetical protein SCH10.25c%2C conserved hypothetical protein%2C len: 143 aa%3B unknown function%2C similar to TR:O06310 (EMBL:Z95324) Mycobacterium tuberculosis hypothetical protein (145 aa)%2C fasta scores%3B opt: 497 z-score: 431.5 E(): 1e-16%2C 55.8%25 identity in 138 aa overlap and TR:O69598 (EMBL:AL023514) Mycobacterium leprae hypothetical protein (137 aa) (56.2%25 identity in 130 aa overlap) gene gene3673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3647 SCO3648 SCO3648 SCH10.26c SCH10.26c 4026217 4027671 - transmembrane efflux protein SCH10.26c%2C probable transmembrane efflux protein%2C len: 484 aa%3B similar to many members of the major facilitator family%2C e.g. SW:PUR8_STRLP (EMBL:X76855)%2C pur8%2C Streptomyces lipmanii puromycin resistance protein (503 aa)%2C fasta scores%3B opt: 871 z-score: 937.9 E(): 0%2C 37.3%25 identity in 475 aa overlap. Contains several hydrophobic%2C probable membrane-spanning regions. Similar to many efflux pumps from Streptomyces coelicolor e.g. TR:O69986 (EMBL:AL022268) SC4H2.31c%2C probable transmembrane efflux protein (515 aa) (38.8%25 identity in 412 aa overlap). Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter%2C score -78.80%2C E-value 0.003 gene gene3674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3648 SCO3649 SCO3649 fba fba 4027742 4028773 - fructose-bisphosphate aldolase catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1%2C6%2C bisphosphate gene gene3675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3649 SCO3650 SCO3650 pyrE pyrE 4028946 4029494 - orotate phosphoribosyltransferase involved in fifth step of pyrimidine biosynthesis%3B converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate gene gene3676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3650 SCO3651 SCO3651 SCH1029c1 SCH1029c1 4029505 4030293 - hypothetical protein SCH10.29c%2C hypothetical protein%2C len: 262 aa%3B unknown function%2C weakly similar to SW:YPHB_ECOLI (EMBL:AE000340)%2C YphB%2C Escherichia coli hypothetical protein (290 aa)%2C fasta scores%3B opt: 225 z-score: 270.0 E(): 1e-07%2C 26.4%25 identity in 239 aa overlap and SW:YIHR_ECOLI (EMBL:L19201)%2C YihR%2C Escherichia coli hypothetical protein (308 aa) (26.3%25 identity in 270 aa overlap) gene gene3677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3651 SCO3652 SCO3652 SCH10.30c SCH10.30c 4030362 4031294 - hypothetical protein SCH10.30c%2C membrane protein%2C len: 310 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains possible hydrophobic membrane spanning region at the C-terminal domain gene gene3678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3652 SCO3653 SCO3653 SCH10.31c SCH10.31c 4031299 4032045 - two-component system regulator SCH10.31c%2C probable two-component system regulator%2C len: 248 aa%3B similar to many e.g. TR:Q53894 (EMBL:U51332)%2C AbsA2%2C Streptomyces coelicolor two-component system regulator homolog involved in negative regulation of antibiotic synthesis (222 aa)%2C fasta scores%3B opt: 583 z-score: 647.2 E(): 9.8e-29%2C 45.0%25 identity in 222 aa overlap. Similar to many other two-component system regulators from Streptomyces coelicolor e.g. SCH10.18c%2C probable two-component regulator (228 aa) (56.2%25 identity in 226 aa overlap). Contains Pfam matches to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 80.40%2C E-value 3.7e-20 and entry PF00072 response_reg%2C Response regulator receiver domain%2C score 127.40%2C E-value 2.5e-34. Contains probable helix-turn-helix motif at aa 196-217 (Score 1378%2C +3.88 SD) gene gene3679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3653 SCO3654 SCO3654 SCH10.32c SCH10.32c 4032042 4033367 - two-component system sensor kinase SCH10.32c%2C probable two-component system sensor kinase%2C len: 441 aa%3B similar to many e.g. TR:Q53893 (EMBL:U51332)%2C AbsA1%2C Streptomyces coelicolor histidine kinase homolog involved in negative regulation of antibiotic synthesis (571 aa)%2C fasta scores%3B opt: 474 z-score: 452.1 E(): 7.2e-18%2C 32.8%25 identity in 381 aa overlap. Also similar to SW:NARX_ECOLI (EMBL:X13360)%2C NarX%2C NarR%2C Escherichia coli nitrate/nitrite sensor protein (598 aa) (28.2%25 identity in 234 aa overlap). Contains hydrophobic%2C probable membrane-spanning regions. Similar to many other two-component system sensor kinases from Streptomyces coelicolor e.g. SCH10.17c%2C probable two-component system sensor (472 aa) (38.0%25 identity in 389 aa overlap). The start codon may be further downstream%2C which would agree with some other bacterial two-component system sensors%3B however%2C NarX has a length comparable to this prediction gene gene3680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3654 SCO3655 SCO3655 SCH10.33c SCH10.33c 4033456 4035120 - spermidine synthase catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine gene gene3681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3655 SCO3656 SCO3656 SCH10.34c SCH10.34c 4035252 4035809 - hypothetical protein SCH10.34c%2C hypothetical protein%2C len: 185 aa%3B unknown function%2C similar to SW:Y0B3_MYCTU (EMBL:Z77724) Mycobacterium tuberculosis hypothetical protein (164 aa)%2C fasta scores%3B opt: 197 z-score: 256.6 E(): 5.6e-07%2C 34.7%25 identity in 167 aa overlap gene gene3682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3656 SCO3657 SCO3657 SCH10.35c SCH10.35c 4035996 4036406 - hypothetical protein SCH10.35c%2C hypothetical protein%2C len: 136 aa%3B unknown function%2C improbable Ala-rich CDS suggested by positional base preference gene gene3683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3657 SCO3658 SCO3658 SCH10.36 SCH10.36 4036689 4037879 + aminotransferase SCH10.36%2C probable aspartate aminotransferase%2C len: 399 aa%3B similar to many e.g. TR:Q56232 (EMBL:D38459) Thermus aquaticus aspartate aminotransferase (385 aa)%2C fasta scores%3B opt: 731 z-score: 825.9 E(): 0%2C 36.5%25 identity in 392 aa overlap. Note that there are three possible start codons. Similar to many aminotransferases from Streptomyces coelicolor e.g. TR:O54170 (EMBL:AL021411) SC7H1.11%2C aminotransferase (382 aa) (36.6%25 identity in 331 aa overlap). Contains Pfam match to entry PF00155 aminotran_1%2C Aminotransferases class-I%2C score 159.80%2C E-value 4.6e-44 gene gene3684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3658 SCO3659 SCO3659 SCH10.37c SCH10.37c 4037975 4038511 - hypothetical protein SCH10.37c%2C hypothetical protein%2C len: 178 aa%3B unknown function%2C has unusally low percentage G+C content gene gene3685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3659 SCO3660 SCO3660 SCH10.38c SCH10.38c 4038637 4040280 - hypothetical protein SCH10.38c%2C hypothetical protein%2C len: 547 aa%3B unknown function%2C N-terminus similar to TR:O69933 (EMBL:AL023861)%2C SC3C8.24%2C Streptomyces coelicolor DNA recombinase (672 aa)%2C fasta scores%3B opt: 192 z-score: 225.8 E(): 2.9e-05%2C 24.5%25 identity in 498 aa overlap. Weakly similar to many resolvases. Has unusally low percentage G+C content. Weakly similar to TR:O69933 (EMBL:AL023861) SC3C8.24%2C Streptomyces coelicolor DNA recombinase (672 aa) (24.5%25 identity in 498 aa overlap) gene gene3686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3660 SCO3661 SCO3661 clpB clpB 4040450 4043047 - ATP-dependent protease ATP-binding subunit clpB%2C SCH10.39c%2C probable clp-family ATP-binding subunit%2C partial CDS%2C len: >853 aa%3B similar to many e.g. SW:CLPB_ECOLI (EMBL:M29364) Escherichia coli ATP-dependent protease regulatory subunit (857 aa)%2C fasta scores%3B opt: 3039 z-score: 2963.3 E(): 0%2C 56.5%25 identity in 844 aa overlap. Similar to TR:O69936 (EMBL:AL023861)%2C SC3C8.27c%2C clpA%2C Streptomyces coelicolor probable clp protease ATP-binding subunit (842 aa) (47.5%25 identity in 854 aa overlap) and SCE94.24c (EMBL:AL049628) Streptomyces coelicolor probable clp protease ATP-binding subunit (841 aa) (48.5%25 identity in 845 aa overlap). Contains Pfam match to entry PF00495 clpA_B%2C Chaperonin clpA/B%2C score 696.80%2C E-value 1e-205%2C PS00870 Chaperonins clpA/B signature 1%2C PS00871 Chaperonins clpA/B signature 2 and two PS00017 ATP/GTP-binding site motif A (P-loop). Contains probable coiled-coil from 421 to 491 (71 residues) (Max score: 1.708%2C probability 1.00)~SCH44.01c%2C clpB%2C ATP-dependent protease ATP-binding subunit (fragment) len: >44 aa%3B highly similar to N-terminal domain of TR:Q9Z6E4 (EMBL:AF076980) Streptomyces albus g. heat shock protein ClpB%2C 857 aa%3B fasta scores: opt: 233 z-score: 369.6 E(): 4e-13%3B 81.8%25 identity in 44 aa overlap gene gene3687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3661 SCO3662 SCO3662 SCH44.02c SCH44.02c 4043330 4043665 - hypothetical protein SCH44.02c%2C unknown%2C len: 111 aa gene gene3688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3662 SCO3663 SCO3663 SCH44.03c SCH44.03c 4043667 4043858 - hypothetical protein SCH44.03c%2C possible membrane protein%2C len: 63 aa. Contains possible hydrophobic membrane spanning regions gene gene3689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3663 SCO3664 SCO3664 SCH44.04 SCH44.04 4043991 4045001 + regulatory protein SCH44.04%2C possible regulatory protein%2C len: 336 aa%3B similar to TR:Q56084 (EMBL:D63904) Streptomyces thermoviolaceus ESA36 (erythropoiesis-stimulating activity)%2C 344 aa%3B fasta scores: opt: 339 z-score: 402.5 E(): 5.9e-15%3B 29.7%25 identity in 286 aa overlap and to Streptomyces coelicolor SCH44.05 aa%3B fasta scores: opt: 973 z-score: 1035.9 E(): 0%3B 48.0%25 identity in 325 aa overlap and to SCH44.06c%2C 394 aa%3B fasta scores: opt: 952 z-score: 1012.5 E(): 0%3B 48.1%25 identity in 320 aa overlap. Contains possible helix-turn-helix motif at residues 278..299 (+3.88 SD) gene gene3690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3664 SCO3665 SCO3665 SCH44.05 SCH44.05 4044998 4045981 + regulatory protein SCH44.05%2C possible regulatory protein%2C len: 327 aa%3B similar to TR:Q56084 (EMBL:D63904) Streptomyces thermoviolaceus ESA36 (erythropoiesis-stimulating activity)%2C 344 aa%3B fasta scores: opt: 270 z-score: 315.4 E(): 4.2e-10%3B 25.7%25 identity in 296 aa overlap and als to Streptomyces colicolor SCH44.04 336 aa%3B fasta scores: opt: 973 z-score: 954.8 E(): 0%3B 48.0%25 identity in 325 aa overlap and SCH44.06c 394 aa%3B fasta scores: opt: 849 z-score: 833.2 E(): 0%3B 45.2%25 identity in 323 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and possible helix-turn-helix motif at residues 278..299 (+5.13 SD) gene gene3691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3665 SCO3666 SCO3666 SCH44.06c SCH44.06c 4045944 4047128 - regulatory protein SCH44.06c%2C possible regulatory protein%2C len: 394 aa%3B similar to TR:Q56084 (EMBL:D63904) Streptomyces thermoviolaceus ESA36 (erythropoiesis-stimulating activity)%2C 344 aa%3B fasta scores: opt: 380 z-score: 432.8 E(): 1.2e-16%3B 31.1%25 identity in 286 aa overlapand to Streptomyces colicolor SCH44.04%2C 336 aa%3B fasta scores: opt: 952 z-score: 855.5 E(): 0%3B 48.1%25 identity in 320 aa overlap and to SCH44.05%2C 327 aa%3B fasta scores: opt: 849 z-score: 764.1 E(): 0%3B 45.2%25 identity in 323 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and possible helix-turn-helix motif at residues 328..349 (+3.19 SD) gene gene3692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3666 SCO3667 SCO3667 SCH44.07c SCH44.07c 4047138 4048256 - solute-binding protein SCH44.07c%2C probable solute-binding protein%2C len: 372 aa%3B similar to TR:O50503 (EMBL:AL009199) Streptomyces coelicolor possible solute-binding protein SC7B7.06%2C 371 aa%3B fasta scores: opt: 1441 z-score: 1539.7 E(): 0%3B 60.6%25 identity in 376 aa overlap and to SW:XYLF_ECOLI (EMBL:U00039) Escherichia coli D-xylose-binding periplasmic protein precursor XylF%2C 330 aa%3B fasta scores: opt: 559 z-score: 602.9 E(): 4.1e-26%3B 34.3%25 identity in 318 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene3693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3667 SCO3668 SCO3668 hspR hspR 4048460 4048915 - heat shock protein SCH44.08c%2C hspR%2C heat shock protein%2C len: 151 aa%3B identical to previously sequenced SW:HSPR_STRCO (EMBL:L46700) Streptomyces coelicolor heat shock protein HspR%2C 151 aa. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and match to Prosite entry PS00552 Bacterial regulatory proteins%2C merR family signature. Contains also possible colied-coil region at aprox. residues 78..106 and possible helix-turn-helix motif at residues 18..39 (+3.49 SD) gene gene3694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3668 SCO3669 SCO3669 dnaJ dnaJ 4048921 4050120 - chaperone protein DnaJ chaperone Hsp40%3B co-chaperone with DnaK%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C dnaK-independent fashion gene gene3695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3669 SCO3670 SCO3670 grpE grpE 4050163 4050840 - heat shock protein GrpE with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%3B may act as a thermosensor gene gene3696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3670 SCO3671 SCO3671 dnaK dnaK 4050837 4052693 - molecular chaperone DnaK heat shock protein 70%3B assists in folding of nascent polypeptide chains%3B refolding of misfolded proteins%3B utilizes ATPase activity to help fold%3B co-chaperones are DnaJ and GrpE%3B multiple copies in some bacteria gene gene3697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3671 SCO3672 SCO3672 SCH35.52 SCH35.52 4052789 4054024 - cell surface biosynthesis associated protein SCH35.52%2C possible cell surface biosynthesis associated protein%2C len: 411 aa%3B previously sequenced therefore almost identical to SW:YDNK_STRCO hypothetical protein from Streptomyces coelicolor (411 aa) fasta scores%3B opt: 2635%2C z-score: 2739.7%2C E(): 0%2C (99.8%25 identity in 411 aa overlap). Also similar to many involved in cell surface biosynthesis e.g. SW:RFE_ECOLI UDP-phosphate alpha-N-acetylglucoaminyltransferase from Escherichia coli (367 aa) fasta scores%3B opt: 185%2C z-score: 200.7%2C E(): 0.00075%2C (25.3%25 identity in 383 aa overlap) and SW:MRAY_BACSU phospho-N-acetylmuramoyl-pentapeptide transferase (324 aa) fasta scores%3B opt: 169%2C z-score: 184.8%2C E(): 0.0058%2C (22.0%25 identity in 309 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene3698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3672 SCO3673 SCO3673 SCH35.51c SCH35.51c 4054268 4056550 + iron-sulfur-binding reductase SCH35.51c%2C probable iron-sulphur-binding reductase%2C len: 433 aa%3B similar to many eg. TR:P96797 (EMBL:Y09870) heterodisulphide reductase from Methanosarcina barkeri (409 aa) fasta scores%3B opt: 427%2C z-score: 463.9%2C E(): 1.6e-18%2C (28.9%25 identity in 443 aa overlap). Contains 2 Pfam matches to entry PF00037 fer4%2C 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and 2 Prosite matches to PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature. Contains also possible hydrophobic membrane spanning regions gene gene3699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3673 SCO3674 SCO3674 SCH35.50c SCH35.50c 4056685 4057986 + sensor kinase SCH35.50c%2C possible sensor kinase%2C len: 433 aa%3B similar to TR:O06213 (EMBL:Z95388) hypothetical protein from Mycobacterium tuberculosis (384 aa) fasta scores%3B opt: 176%2C z-score: 174.4%2C E(): 0.022%2C (31.0%25 identity in 210 aa overlap) and SW:PKAA_STRCO Ser/Thr protein kinase from Streptomyces coelicolor (543 aa) fasta scores%3B opt: 160%2C z-score: 157.4%2C E(): 0.19%2C (29.4%25 identity in 262 aa overlap). Contains possible N-terminal signal sequence and two Prosite matches to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene3700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3674 SCO3675 SCO3675 SCH35.49c SCH35.49c 4058105 4059337 + hypothetical protein SCH35.49c%2C conserved hypothetical protein%2C len: 410aa%3B Similar to others from Streptomyces coelicolor. Contains a possible N-terminal signal sequence. gene gene3701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3675 SCO3676 SCO3676 SCH35.48c SCH35.48c 4059415 4060467 + hypothetical protein SCH35.48c%2C possible integral membrane protein%2C len: 350aa%3B Contains possible membrane spanning hydrophobic regions in the C-terminal half and a hydrophobic N-terminal half. gene gene3702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3676 SCO3677 SCO3677 SCH35.47 SCH35.47 4060547 4061044 - purine phosphoribosyltransferase SCH35.47%2C possible purine phosphoribosyltransferase%2C len: 165 aa%3B similar to many eg. TR:P74916 (EMBL:D37928) purine phosphoribosyltransferase from Thermus flavus (154 aa) fasta scores%3B opt: 222%2C z-score: 291.9%2C E(): 6.3e-09%2C 931.8%25 identity in 151 aa overlap). gene gene3703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3677 SCO3678 SCO3678 dcd dcd 4061079 4061654 - deoxycytidine triphosphate deaminase Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis gene gene3704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3678 SCO3679 SCO3679 SCH35.45c SCH35.45c 4062587 4064491 + hypothetical protein SCH35.45c%2C unknown%2C len: 634 aa%3B similar to TR:CAA22732 (EMBL:AL035161) hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores%3B opt: 551%2C z-score: 565.3%2C E(): 3.7e-24%2C (29.7%25 identity in 683 aa overlap). Contains Pfam match to entry PF00989 PAS%2C PAS domain. gene gene3706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3679 SCO3680 SCO3680 SCH35.44 SCH35.44 4064575 4064868 - hypothetical protein SCH35.44%2C unknown%2C len: 97aa gene gene3707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3680 SCO3681 SCO3681 SCH35.43c SCH35.43c 4064888 4065388 + hypothetical protein SCH35.43c%2C unknown%2C len: 166aa%3B similar to TR:Q9X8W6 (EMBL:AL078610) SCH35.40 hypothetical protein from Streptomyces coelicolor. gene gene3708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3681 SCO3682 SCO3682 SCH35.42c SCH35.42c 4065489 4066526 + delta fatty acid desaturase SCH35.42c%2C possible delta fatty acid desaturase%2C len: 345 aa%3B similar to many (prokaryote and eukaryote) egs. TR:CAA11032 (EMBL:AJ222980) delta6-acyl-group desaturase from Physcomitrella patens (moss) (525 aa) fasta scores%3B opt: 499%2C z-score: 601.5%2C E(): 3.6e-26%2C (29.5%25 identity in 329 aa overlap) and TR:Q55240 (EMBL:D13780) omega 3 desaturase from Synechocystis sp. strain PCC6803 (359 aa) fasta scores%3B opt: 207%2C z-score: 253.0%2C E(): 9.1e-07%2C (22.6%25 identity in 283 aa overlap). Contains TTA leucine codon%2C possible target for bldA regulation. Contains possible hydrophobic membrane spanning regions gene gene3709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3682 SCO3683 SCO3683 SCH35.41 SCH35.41 4066523 4066798 - hypothetical protein SCH35.41%2C membrane protein%2C len: 91 aa. Contains possible hydrophobic membrane spanning regions gene gene3710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3683 SCO3684 SCO3684 SCH35.40 SCH35.40 4066804 4067394 - hypothetical protein SCH35.40%2C unknown%2C len: 196aa%3B similar to neighbouring gene SCH35.39c. gene gene3711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3684 SCO3685 SCO3685 SCH35.39c SCH35.39c 4067767 4068168 + hypothetical protein SCH35.39c%2C unknown%2C len: 133aa%3B similar to TR:Q9X8W6 (EMBL:AL078610) SCH35.40 hypothetical protein (196 aa) fasta scores%3B 47.794%25 identity (50.000%25 ungapped) in 136 aa overlap . gene gene3712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3685 SCO3686 SCO3686 SCH35.38 SCH35.38 4068136 4068669 - hypothetical protein SCH35.38%2C unknown%2C len: 177aa gene gene3713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3686 SCO3687 SCO3687 SCH35.37c SCH35.37c 4069088 4069687 + hypothetical protein SCH35.37c%2C unknown%2C len: 199aa%3B N-terminal region alanine-rich%2C C-terminal region glutamic acid-rich. Similar to TR:CAA22040 (EMBL:AL033505) hypothetical protein from Streptomyces coelicolor (239 aa) fasta scores%3B opt: 205%2C z-score: 204.5%2C E(): 0.00046%2C (36.1%25 identity in 202 aa overlap). gene gene3714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3687 SCO3688 SCO3688 SCH35.36c SCH35.36c 4069691 4070653 + hypothetical protein SCH35.36c%2C hypothetical protein%2C len: 320 aa%3B glutamic acid rich%2C similar to TR:CAA22041 (EMBL:AL033505) hypothetical protein from Streptomyces coelicolor (376 aa) fasta scores%3B opt: 1014%2C z-score: 1002.4%2C E(): 0%2C (51.1%25 identity in 323 aa overlap) gene gene3715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3688 SCO3689 SCO3689 SCH35.35 SCH35.35 4071163 4071573 - hypothetical protein SCH35.35%2C unknown%2C len: 136aa%3B predicted based upon amino acid and codon usage. gene gene3716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3689 SCO3690 SCO3690 SCH35.34c SCH35.34c 4071572 4072381 + hydrolase SCH35.34c%2C possible hydrolase%2C len: 269 aa%3B similar to TR: O07015 (EMBL:Z94043) hypothetical protein from Bacillus subtilis (269 aa) fasta scores%3B opt: 907%2C z-score: 1096.7%2C E(): 0%2C (47.7%25 identity in 262 aa overlap). Also weakly similar to TR:BAA34263 (EMBL:AB014348) 2-hydroxy-6-oxo-6-phenylehexa-2%2C4-dienoate hydrolase from Rhodococcus erythropolis TA421 (297 aa) fasta scores%3B opt: 227%2C z-score: 278.9%2C E(): 3.3e-08%2C (27.1%25 identity in 277 aa overlap). Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene3717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3690 SCO3691 SCO3691 SCH35.33c SCH35.33c 4072381 4073649 + regulatory protein SCH35.33c%2C possible regulatory protein%2C len: 422 aa%3B regions of similarity to many egs. TR:O86807 (EMBL:AL031031) regulatory protein from Streptomyces coelicolor (916 aa) fasta scores%3B opt: 541%2C z-score: 629.7%2C E(): 9.6e-28%2C (35.5%25 identity in 349 aa overlap) SW:RSBU_BACSU sigma factor associated regulatory protein from Bacillus subtilis (335 aa) fasta scores%3B opt: 214%2C z-score: 253.9%2C E(): 8.2e-07%2C (26.8%25 identity in 228 aa overlap). Contains probable coiled-coil region at approx. 150-165aa. gene gene3718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3691 SCO3692 SCO3692 SCH35.32c SCH35.32c 4073646 4074005 + anti-sigma factor antagonist SCH35.32c%2C possible anti-sigma factor antagonist%2C len: 119aa%3B similar to many egs. TR:CAB38486 (EMBL:AL035636) anti-sigma factor antagonist from Streptomyces coelicolor (113 aa) fasta scores%3B opt: 218%2C z-score: 288.7%2C E(): 9.4e-09%2C (34.9%25 identity in 109 aa overlap) and SW:SP21_BACSU anti-sigma F factor antagonist from Bacillus subtilis (116 aa) fasta scores%3B opt: 152%2C z-score: 206.5%2C E(): 0.00036%2C (30.9%25 identity in 94 aa overlap). gene gene3719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3692 SCO3693 SCO3693 SCH35.31c SCH35.31c 4074209 4074751 + hypothetical protein SCH35.31c%2C unknown%2C len: 180aa%3B similar to TR:O33344 (EMBL:AL008883) hypothetical protein from Mycobacterium tuberculosis (194 aa) fasta scores%3B opt: 266%2C z-score: 329.4%2C E(): 5.1e-11%2C (34.6%25 identity in 179 aa overlap). Contains TTA codon%2C possible target for bldA regulation. gene gene3720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3693 SCO3694 SCO3694 SCH35.30 SCH35.30 4074756 4075130 - transcriptional regulator SCH35.30%2C possible transcriptional regulator%2C len: 124aa%3B similar to many eg. TR:CAA09641 (EMBL:AJ011500) transcriptional regulator from Streptomyces violaceoruber (196 aa) fasta scores%3B opt: 206%2C z-score: 269.5%2C E(): 1.1e-07%2C (31.2%25 identity in 109 aa overlap). Contains probable helix-turn-helix at 2-23aa (+3.36 SD) gene gene3721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3694 SCO3695 SCO3695 SCH35.29 SCH35.29 4075117 4075605 - hypothetical protein SCH35.29%2C possible hypothetical protein%2C len: 162aa%3B contains possible N-terminal signal sequence. gene gene3722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3695 SCO3696 SCO3696 SCH35.28c SCH35.28c 4075938 4076306 + transcriptional regulator SCH35.28c%2C probable transcriptional regulator%2C len: 122aa%3B similar to many egs. TR:P71941 (EMBL:Z80225) transcriptional regulator from Mycobacterium tuberculosis (126 aa) fasta scores%3B opt: 390%2C z-score: 503.7%2C E(): 1e-20%2C (56.6%25 identity in 122 aa overlap) and SW:ARSR_ECOLI arsenical resistance operon repressor from Escherichia coli (117 aa) fasta scores%3B opt: 198%2C z-score: 263.7%2C E(): 2.3e-07%2C (38.8%25 identity in 80 aa overlap). Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene3723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3696 SCO3697 SCO3697 SCH35.27 SCH35.27 4076249 4077469 - oxidoreductase SCH35.27%2C possible oxidoreductase%2C len: 406aa%3B similar to many hypothetical proteins eg. TR:O07085 (EMBL:U93876) from Bacillus subtilis (345 aa) fasta scores%3B opt: 388%2C z-score: 307.0%2C E(): 9e-10%2C (34.1%25 identity in 179 aa overlap). Also similar to SW:AHPF_SALTY Alkyl hydroperoxide reductase subunit from Salmonella typhimurium (521 aa) fasta scores%3B opt: 222%2C z-score: 180.7%2C E(): 0.0097%2C (30.8%25 identity in 201 aa overlap). NB. Overlaps downstream CDS. gene gene3724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3697 SCO3698 SCO3698 SCH35.26 SCH35.26 4077583 4078692 - heavy metal resistance membrane protein SCH35.26%2C possible heavy metal resistance membrane protein%2C len: 369aa%3B similar to many hypothetical proteins eg. TR:P71942 (EMBL:Z80225) from Mycobacterium tuberculosis (498 aa) fasta scores%3B opt: 1731%2C z-score: 2029.9%2C E(): 0%2C (73.8%25 identity in 362 aa overlap). Also similar to SW:ACR3_YEAST arsenical resistance protein from Saccharomyces cerevisiae (yeast) (404 aa) fasta scores%3B opt: 562%2C z-score: 662.8%2C E(): 1.4e-29%2C (33.1%25 identity in 375 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene3725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3698 SCO3699 SCO3699 SCH35.25 SCH35.25 4078689 4078997 - transcriptional regulator SCH35.25%2C probable transcriptional regulator%2C len: 102aa%3B similar to many eg. SW:ARSR_ECOLI arsenical resistance operon from Escherichia coli (117 aa) fasta scores%3B opt: 147%2C z-score: 212.9%2C E(): 0.00016%2C (36.6%25 identity in 71 aa overlap). Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene3726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3699 SCO3700 SCO3700 SCH35.24c SCH35.24c 4079089 4079502 + heavy metal reductase SCH35.24c%2C possible heavy metal reductase%2C len: 137aa%3B similar to many arsenate reductases eg. SW:ARSC_STAAU ArsC%2C arsenate reductase from Staphylococcus aureus (131 aa) fasta scores%3B opt: 311%2C z-score: 363.4%2C E(): 6.5e-13%2C (38.6%25 identity in 127 aa overlap). Also similar to the C-terminus of TR:P71942 (EMBL:Z80225) hypothetical protein from Mycobacterium tuberculosis (498 aa) fasta scores%3B opt: 567%2C z-score: 641.0%2C E(): 2.2e-28%2C (65.1%25 identity in 129 aa overlap). gene gene3727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3700 SCO3701 SCO3701 SCH35.23c SCH35.23c 4079499 4079729 + hypothetical protein SCH35.23c%2C unknown%2C len: 76aa%3B similar to the N-terminus of many thioredoxin reductases from prokaryotes and eukaryotes egs. SW:TRXB_STRCO TrxB%2C thioredoxin reductase from Streptomyces coelicolor (319 aa) fasta scores%3B opt: 215%2C z-score: 280.7%2C E(): 2.6e-08%2C (63.2%25 identity in 57 aa overlap) and SW:TRXB_NEUCR Cys-9 thioredoxin reductase from Neurospora crassa (334 aa) fasta scores%3B opt: 158%2C z-score: 209.4%2C E(): 0.00025%2C (51.8%25 identity in 56 aa overlap). gene gene3728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3701 SCO3702 SCO3702 SCH35.22c SCH35.22c 4079863 4080510 + DNA-binding protein SCH35.22c%2C possible DNA-binding protein%2C len: 215aa%3B similar to TR:Q51078 (EMBL:Z21683) hypothetical DNA-binding protein from Streptomyces lactamdurans (214 aa) fasta scores%3B opt: 1210%2C z-score: 1460.4%2C E(): 0%2C 77.2%25 identity in 215 aa overlap gene gene3729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3702 SCO3703 SCO3703 SCH35.21c SCH35.21c 4080650 4081045 + substrate binding protein SCH35.21c%2C possible substrate binding protein%2C len: 131aa%3B similar to many eg. SW:MOP2_CLOPA molybdenum-pterin binding protein from Clostridium pasteurianum (68 aa) fasta scores%3B opt: 150%2C z-score: 204.%2C1 E(): 0.00048%2C (42.9%25 identity in 63 aa overlap). Contains probable helix-turn-helix at 5-26aa (+5.01 SD). gene gene3730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3703 SCO3704 SCO3704 SCH35.20c SCH35.20c 4081222 4082031 + substrate-binding transport protein SCH35.20c%2C possible substrate-binding transport protein%2C len: 269aa%3B similar to many egs. TR:O31229 (EMBL:Y10817) molybdate-binding periplasmic transport protein from Arthrobacter nicotinovorans (260 aa) fasta scores%3B opt: 613%2C z-score: 670.6%2C E(): 5e-30%2C (43.4%25 identity in 256 aa overlap) and SW:MODA_ECOLI molybdate-binding periplasmic transport protein from Escherichia coli (257 aa) fasta scores%3B opt: 163%2C z-score: 186.1%2C E(): 0.0049%2C (31.7%25 identity in 249 aa overlap). Contains possible N-terminal signal sequence. gene gene3731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3704 SCO3705 SCO3705 SCH35.19c SCH35.19c 4082028 4082879 + ABC transporter membrane subunit SCH35.19c%2C ABC transporter membrane subunit%2C len: 283aa%3B similar to many egs. TR:O31230 (EMBL:Y10817) from Arthrobacter nicotinovorans (239 aa) fasta scores%3B opt: 745%2C z-score: 854.5%2C E(): 0%2C (52.8%25 identity in 229 aa overlap) and SW:MODB_ECOLI molybdate transport permease from Escherichia coli (229 aa) fasta scores%3B opt: 639%2C z-score: 734.6%2C E(): 0%2C (44.7%25 identity in 219 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains possible membrane spanning hydrophobic regions. gene gene3732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3705 SCO3706 SCO3706 SCH35.18c SCH35.18c 4082876 4084000 + ABC transporter ATP-binding protein SCH35.18c%2C probable ABC transporter ATP-binding subunit%2C len: 374aa%3B similar to many egs. TR:O31231 (EMBL:Y10817) from Arthrobacter nicotinovorans (349 aa) fasta scores%3B opt: 816%2C z-score: 875.0%2C E(): 0%2C (43.2%25 identity in 340 aa overlap) and TR:O86751 (EMBL:AL031035) ABC transporter ATP-binding subunit from Streptomyces coelicolor (348 aa) fasta scores%3B opt: 653%2C z-score: 701.9%2C E(): 9e-32%2C (38.6%25 identity in 321 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3706 SCO3707 SCO3707 SCH35.17 SCH35.17 4084035 4084604 - lipoprotein SCH35.17%2C lipoprotein%2C len: 189 aa%3B weakly similar to TR:Q54334 (EMBL:U22894) hypothetical protein from the AUD1 region of Streptomyces lividans 66 (184 aa) fasta scores%3B opt: 127%2C z-score: 144.8%2C E(): 0.98%2C (28.4%25 identity in 162 aa overlap). Also weakly similar to SW:T2D8_HUMAN transcription initiation factor from Homo sapiens (human) (218 aa) fasta scores%3B opt: 152%2C%2C z-score: 169.1 E(): 0.044%2C (32.3%25 identity in 167 aa overlap). Also contains properly situated Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3707 SCO3708 SCO3708 SCH35.16 SCH35.16 4084704 4085324 - hypothetical protein SCH35.16%2C possible integral membrane protein%2C len: 206aa%3B Contains possible membrane spanning hydrophobic regions. gene gene3735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3708 SCO3709 SCO3709 SCH35.15 SCH35.15 4085317 4085871 - ECF sigma factor SCH35.15%2C possible ECF sigma factor%2C len: 184 aa%3B similar to many e.g. SW:RPOE_STRCO sigma E from Streptomyces coelicolor (176 aa) fasta scores%3B opt: 216%2C z-score: 250.5%2C E(): 1.3e-06%2C (29.2%25 identity in 161 aa overlap). gene gene3736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3709 SCO3710 SCO3710 SCH35.14c SCH35.14c 4086039 4087673 + large integral membrane protein SCH35.14c%2C possible large integral membrane protein%2C len: 544aa%3B Contains possible membrane spanning hydrophobic regions. Region (282-346aa) of similarity to SW:YZ25_MYCTU hypothetical protein from from Mycobacterium tuberculosis (535aa) blast scores: Identities %3D 32/69 (46%25)%2C Positives %3D 37/69 (53%25). gene gene3737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3710 SCO3711 SCO3711 SCH35.13c SCH35.13c 4087742 4088053 + small membrane protein SCH35.13c%2C possible small membrane protein%2C len: 103 aa%3B contains possible membrane spanning hydrophobic regions. gene gene3738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3711 SCO3712 SCO3712 SCH35.12c SCH35.12c 4088148 4088984 + hydrolase SCH35.12c%2C possible hydrolase%2C len: 278aa%3B similar to many polysaccharide deacetylases from Rhizobia spp. eg. SW:NODB_RHIME chito-oligosaccharide deacetylase from Rhizobium meliloti (217 aa) fasta scores%3B opt: 399%2C z-score: 428.0%2C E(): 1.6e-16%2C (36.9%25 identity in 187 aa overlap). gene gene3739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3712 SCO3713 SCO3713 SCH35.11 SCH35.11 4088998 4089171 - hypothetical protein SCH35.11%2C unknown%2C len: 57aa gene gene3740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3713 SCO3714 SCO3714 SCH35.10 SCH35.10 4089285 4090508 - transposase SCH35.10%2C probable transposase%2C len: 407aa%3B similar to many egs. TR:O83029 (EMBL:AB016803) TnpC%2C transposase from Deinococcus radiodurans (408 aa) fasta scores%3B opt: 837%2C z-score: 956.6%2C E(): 0%2C (37.6%25 identity in 399 aa overlap) and TR:P73816 (EMBL:D90909) transposase from Synechocystis sp. PCC6803 (400 aa) fasta scores%3B opt: 1095%2C z-score: 1250.1%2C E(): 0%2C (50.9%25 identity in 381 aa overlap). Contains Pfam match to entry PF01385 Transposase_2%2C Probable transposase. gene gene3741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3714 SCO3715 SCO3715 SCH35.09 SCH35.09 4090396 4091067 - ECF sigma factor SCH35.09%2C possible ECF sigma factor%2C len: 223aa%3B similar to many egs. TR:O53378 (EMBL:AL021841) sigma factor from Mycobacterium tuberculosis (312 aa) fasta scores%3B opt: 357%2C z-score: 418.3%2C E(): 5.7e-16%2C (33.2%25 identity in 226 aa overlap) and SW:RPOE_STRCO sigma factor E from Streptomyces coelicolor (176 aa) fasta scores%3B opt: 131%2C z-score: 162.5%2C E(): 0.1%2C (33.3%25 identity in 114 aa overlap). NB. Overlaps with downstream CDS. gene gene3742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3715 SCO3716 SCO3716 SCH35.08 SCH35.08 4091267 4091944 - potassium-transporting ATPase subunit C one of the components of the high-affinity ATP-driven potassium transport (or KDP)system%2C which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions%3B the C subunit may be involved in assembly of the KDP complex gene gene3743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3716 SCO3717 SCO3717 SCH35.07 SCH35.07 4091950 4094073 - potassium-transporting ATPase subunit B One of the components of the high-affinity ATP-driven potassium transport (or KDP) system%2C which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions gene gene3744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3717 SCO3718 SCO3718 SCH35.06 SCH35.06 4094070 4095734 - potassium-transporting ATPase subunit A catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions gene gene3745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3718 SCO3719 SCO3719 SCH35.05 SCH35.05 4095742 4095831 - small membrane protein SCH35.05%2C possible small membrane protein%2C len: 29aa%3B predicted based on amino acid and codon usage methods. Comprised mostly of hydrophobic amino acids. Similar to SW:KDPF_ECOLI predicted membrane protein from the high-affinity potassium-uptake kdpABC operon of Escherichia coli (29 aa) fasta scores%3B opt: 75%2C z-score: 156.3%2C E(): 0.22%2C (44.8%25 identity in 29 aa overlap). gene gene3746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3719 SCO3721 SCO3721 SCH35.03 SCH35.03 4096157 4096780 - carbonic anhydrase SCH35.03%2C probable carbonic anhydrase%2C len: 207aa%3B similar to many (both prokayote and eukaryote) egs. TR:Q39589 (EMBL:U41189) an algal mitochondrial carbonic anhydrase from Chlamydomonas reinhardtii (267 aa) fasta scores%3B opt: 431%2C z-score: 502.8%2C E(): 1.1e-20%2C (37.9%25 identity in 198 aa overlap) and SW:CYNT_ECOLI carbonic anhydrase from Escherichia coli (219 aa) fasta scores%3B opt: 227%2C z-score: 271.0%2C E(): 9.1e-08%2C (30.9%25 identity in 178 aa overlap). Contains Prosite match to PS00704 Prokaryotic-type carbonic anhydrases signature 1 and Pfam match to entry PF00484 Pro_CA%2C Prokaryotic-type carbonic anhydrases. gene gene3747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3721 SCO3722 SCO3722 SCH35.02 SCH35.02 4096845 4097198 - transcriptional regulator SCH35.02%2C possible transcriptional regulator%2C len: 117aa%3B similar to many eg. TR:O53626 (EMBL:AL021428) transcriptional regulator from Mycobacterium tuberculosis (114 aa) fasta scores%3B opt: 404%2C z-score: 526.2%2C E(): 5.6e-22%2C (58.2%25 identity in 110 aa overlap) and SW:NOLR_RHIME NolR negative transacting factor controlling the nod regulon in Rhizobium meliloti (122 aa) fasta scores%3B opt: 175%2C z-score: 237.2%2C E(): 7e-06%2C (35.2%25 identity in 88 aa overlap). Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene3748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3722 SCO3723 SCO3723 SCH22A.01 SCH22A.01 4097454 4098950 + regulatory protein SCH22A.01%2C possible regulatory protein (fragment)%2C len: >465 aa %3B similar to TR:CAB59599 (EMBL:AL132662) Streptomyces coelicolor hypothetical regulatory protein SCF11.22%2C 877 aa%3B fasta scores: opt: 708 z-score: 765.1 E(): 0%3B 34.5%25 identity in 466 aa overlap. Contains Pfam match to entry PF01590 GAF%2C GAF domain and possible coiled-coil region at residues 48..60~SCH35.01c%2C partial CDS%2C unknown%2C len: >76aa gene gene3749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3723 SCO3724 SCO3724 SCH22A.02c SCH22A.02c 4098986 4099468 - hypothetical protein SCH22A.02c%2C hypothetical protein%2C len: 160 aa%3B similar to TR:Q9X7Q5 (EMBL:AL049587) Streptomyces coelicolor hypothetical 17.1 kD protein SC5F2A.32%2C 161 aa%3B fasta scores: opt: 256 z-score: 310.3 E(): 7.3e-10%3B 39.4%25 identity in 160 aa overlap gene gene3750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3724 SCO3725 SCO3725 SCH22A.03c SCH22A.03c 4099520 4100809 - hypothetical protein SCH22A.03c%2C possible membrane protein%2C len: 429 aa. similar to TR:Q9F388 (EMBL:AL450165) from Streptomyces coelicolor. Contains possible hydrophobic membrane spanning regions gene gene3751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3725 SCO3726 SCO3726 SCH22A.04c SCH22A.04c 4100888 4101508 - hypothetical protein SCH22A.04c%2C unknown%2C len: 206 aa gene gene3752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3726 SCO3727 SCO3727 SCH22A.05 SCH22A.05 4101639 4102223 + stress response protein SCH22A.05%2C possible stress response protein%2C len: 194 aa%3B similar to TR:AAF11772 (EMBL:AE002055) Deinococcus radiodurans tellurium resistance protein TerZ%2C 195 aa%3B fasta scores: opt: 300 z-score: 364.6 E(): 6.8e-13%3B 31.5%25 identity in 178 aa overlap and to SW:TERZ_SERMA (EMBL:L38824) Serratia marcescens tellurium resistance protein TerZ%2C 193 aa%3B fasta scores: opt: 263 z-score: 321.2 E(): 1.8e-10%3B 28.2%25 identity in 195 aa overlap gene gene3753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3727 SCO3728 SCO3728 SCH22A.06c SCH22A.06c 4102349 4103080 - hypothetical protein SCH22A.06c%2C possible membrane protein%2C len: 243 aa. Contains possible hydrophobic membrane spanning regions gene gene3754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3728 SCO3729 SCO3729 SCH22A.07c SCH22A.07c 4103188 4103970 - regulatory protein SCH22A.07c%2C possible regulatory protein%2C len: 260 aa%3B similar to SW:BRPA_STRHY (EMBL:M64783) Streptomyces hygroscopicus bialaphos biosynthetic pathway regulatory protein BrpA%2C 256 aa%3B fasta scores: opt: 267 z-score: 309.8 E(): 7.8e-10%3B 33.8%25 identity in 160 aa overlap. Contains possible helix-turn-helix motif at residues 214..235 (+3.28 SD) gene gene3755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3729 SCO3730 SCO3730 SCH22A.08 SCH22A.08 4104198 4105055 + oxidoreductase SCH22A.08%2C possible oxidoreductase%2C len: 285 aa%3B similar to TR:Q9X7T6 (EMBL:AL049863) Streptomyces coelicolor oxidoreductase SC5H1.28c%2C 305 aa%3B fasta scores: opt: 778 z-score: 848.8 E(): 0%3B 52.1%25 identity in 288 aa overlap gene gene3756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3730 SCO3731 SCO3731 SCH22A.09 SCH22A.09 4105340 4105543 + cold-shock protein SCH22A.09%2C scoF1%2C cold-shock protein%2C len: 67 aa%3B highly similar to TR:O54117 (EMBL:AL021529) Streptomyces coelicolor cold-shock domain protein SC10A5.26c%2C 67 aa and to SW:CSPF_STRCO (EMBL:X92686) Streptomyces coelicolor cold shock protein ScoF%2C 67 aa. Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain and match to Prosite entry PS00352 'Cold-shock' DNA-binding domain signature gene gene3757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3731 SCO3732 SCO3732 SCH22A.10 SCH22A.10 4105819 4107405 + DEAD/DEAH box helicase SCH22A.10%2C probable DEAD-box RNA helicase%2C len: 528 aa%3B similar to TR:O54116 (EMBL:AL021529) Streptomyces coelicolor DEAD-box RNA helicase SC10A5.25c%2C 498 aa%3B fasta scores: opt: 2348 z-score: 2252.6 E(): 0%3B 74.9%25 identity in 506 aa overlap and to SW:RHLE_ECOLI (EMBL:L02123) Escherichia coli ATP-dependent RNA helicase RhlE%2C 454 aa%3B fasta scores: opt: 874 z-score: 843.8 E(): 0%3B 36.6%25 identity in 470 aa overlap. Contains two Pfam matches to entries PF00270 DEAD%2C DEAD/DEAH box helicase and PF00271 helicase_C%2C Helicases conserved C-terminal domain%2C and two matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3732 SCO3733 SCO3733 SCH22A.11 SCH22A.11 4107493 4107822 + hypothetical protein SCH22A.11%2C hypothetical protein%2C len: 109 aa%3B similar to TR:O54114 (EMBL:AL021529) Streptomyces coelicolor hypothetical 11.3 kD protein SC10A5.23c%2C 103 aa%3B fasta scores: opt: 483 z-score: 544.6 E(): 6.5e-23%3B 72.0%25 identity in 100 aa overlap gene gene3759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3733 SCO3734 SCO3734 SCH22A.12c SCH22A.12c 4107830 4108183 - hypothetical protein SCH22A.12c%2C hypothetical protein%2C len: 117 aa%3B similar to TR:AAF09825 (EMBL:AE001885) Deinococcus radiodurans conserved hypothetical protein DR0242%2C 112 aa%3B fasta scores: opt: 128 z-score: 175.1 E(): 0.025%3B 32.7%25 identity in 110 aa overlap gene gene3760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3734 SCO3735 SCO3735 SCH22A.13c SCH22A.13c 4108183 4108686 - hypothetical protein SCH22A.13c%2C possible hypothetical protein%2C len: 167 aa. Contains possible N-teminal region signal peptide sequence. High content in proline and alanine residues gene gene3761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3735 SCO3736 SCO3736 SCH22A.14c SCH22A.14c 4108736 4109227 - RNA polymerase ECF sigma factor SCH22A.14c%2C probable RNA polymerase ECF sigma factor%2C len: 163 aa%3B similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE%2C 176 aa%3B fasta scores: opt: 214 z-score: 282.2 E(): 2.7e-08%3B 32.7%25 identity in 159 aa overlap gene gene3762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3736 SCO3737 SCO3737 SCH22A.15c SCH22A.15c 4109279 4109905 - lipoprotein SCH22A.15c%2C possible lipoprotein%2C len: 208 aa%3B similar to TR:CAB63184 (EMBL:AL133469) Streptomyces coelicolor hypothetical protein SCM10.23%2C 221 aa%3B fasta scores: opt: 495 z-score: 484.3 E(): 1.5e-19%3B 42.4%25 identity in 205 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3737 SCO3738 SCO3738 SCH22A.16c SCH22A.16c 4109902 4110471 - hypothetical protein SCH22A.16c%2C possible integral membrane protein%2C len: 189 aa. Contains possible hydrophobic membrane spanning regions gene gene3764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3738 SCO3739 SCO3739 SCH22A.17 SCH22A.17 4110508 4111512 + epimerase SCH22A.17%2C possible epimerase%2C len: 334 aa%3B similar to TR:O69123 (EMBL:AF064070) Burkholderia pseudomallai epimerase/dehydratase WbiB%2C 363 aa%3B fasta scores: opt: 547 z-score: 590.5 E(): 1.8e-25%3B 35.9%25 identity in 351 aa overlap and to SW:GALE_ERWAM (EMBL:X76172) Erwinia amylovora UDP-glucose 4-epimerase (EC 5.1.3.2) GalE%2C 337 aa%3B fasta scores: opt: 241 z-score: 265.2 E(): 2.4e-07%3B 28.1%25 identity in 360 aa overlap. Contains Pfam match to entry PF01370 Epimerase%2C NAD dependent epimerase/dehydratase family gene gene3765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3739 SCO3740 SCO3740 SCH22A.18c SCH22A.18c 4111533 4112645 - histidine kinase SCH22A.18c%2C probable histidine kinase%2C len: 370 aa%3B similar to TR:CAB54569 (EMBL:AJ006392) Streptococcus pneumoniae histidine kinase HK02%2C 449 aa%3B fasta scores: opt: 425 z-score: 452.2 E(): 9.2e-18%3B 33.7%25 identity in 285 aa overlap and to SW:RESE_BACSU (EMBL:L09228) Bacillus subtilis sensor protein ResE (EC 2.7.3.-)%2C 589 aa%3B fasta scores: opt: 434 z-score: 460.1 E(): 3.4e-18%3B 35.8%25 identity in 229 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase. Contains also possible coiled-coil region at residues 83..95. Contains possible hydrophobic membrane spanning regions gene gene3766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3740 SCO3741 SCO3741 SCH22A.19c SCH22A.19c 4112648 4113418 - response regulator SCH22A.19c%2C probable response regulator%2C len: 256 aa%3B similar to TR:P74922 (EMBL:U67196) Thermotoga maritima DNA-binding response regulator DrrA%2C 239 aa%3B fasta scores: opt: 664 z-score: 686.2 E(): 8.4e-31%3B 45.3%25 identity in 234 aa overlap and to SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1%2C 225 aa%3B fasta scores: opt: 630 z-score: 652.1 E(): 6.7e-29%3B 47.1%25 identity in 221 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal. Contains also possible N-terminal region signal peptide sequence gene gene3767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3741 SCO3742 SCO3742 SCH22A.20 SCH22A.20 4113665 4114393 + glycosyltransferase SCH22A.20%2C possible glycosyltransferase%2C len: 242 aa%3B similar to various glycosyltransferases%2C e.g. TR:CAB50363 (EMBL:AJ248287) Pyrococcus abyssi dolichol-P-glucose synthetase%2C 378 aa%3B fasta scores: opt: 330 z-score: 398.4 E(): 9e-15%3B 31.4%25 identity in 220 aa overlap gene gene3768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3742 SCO3743 SCO3743 SCH22A.21 SCH22A.21 4114390 4115031 + hypothetical protein SCH22A.21%2C hypothetical protein%2C len: 213 aa%3B similar to various hypothetical proteins%2C e.g. TR:P74231 (EMBL:D90913) Synechocystis sp. hypothetical 23.5 kD protein%2C 211 aa%3B fasta scores: opt: 217 z-score: 247.2 E(): 2.4e-06%3B 30.7%25 identity in 192 aa overlap gene gene3769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3743 SCO3744 SCO3744 SCH22A.22 SCH22A.22 4115028 4115813 + hypothetical protein SCH22A.22%2C unknown%2C len: 261 aa gene gene3770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3744 SCO3745 SCO3745 SCH22A.23c SCH22A.23c 4115666 4116157 - lipoprotein SCH22A.23c%2C possible lipoprotein%2C len: 163 aa%3B similar to TR:P96401 (EMBL:Z92669) Mycobacterium tuberculosis hypothetical 20.1 kD protein%2C 182 aa%3B fasta scores: opt: 287 z-score: 377.4 E(): 1.3e-13%3B 38.9%25 identity in 162 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. Also contains possible hydrophobic membrane spanning regions gene gene3771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3745 SCO3746 SCO3746 SCH22A.24c SCH22A.24c 4116154 4117440 - hypothetical protein SCH22A.24c%2C membrane protein%2C len: 412 aa%3B similar to TR:P96400 (EMBL:Z92669) Mycobacterium tuberculosis hypothetical 47.4 kD protein%2C 442 aa%3B fasta scores: opt: 728 z-score: 812.0 E(): 0%3B 52.1%25 identity in 411 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3746 SCO3747 SCO3747 SCH22A.25 SCH22A.25 4117506 4118876 + hypothetical protein SCH22A.25%2C possible integral membrane protein%2C len: 456 aa%3B similar to TR:O06407 (EMBL:Z95558) Mycobacterium tuberculosis hypothetical 47.7 kD protein MTCY25D10.20c%2C 449 aa%3B fasta scores: opt: 1164 z-score: 1309.6 E(): 0%3B 49.6%25 identity in 464 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3747 SCO3748 SCO3748 f40 f40 4118957 4119160 - cold shock protein SCH22A.26c%2C f40%2C cold shock protein%2C len: 67 aa%3B identical to previously sequenced TR:AAD49327 (EMBL:AF162937) Streptomyces coelicolor F40 and highly similar to SW:CSPF_STRCO (EMBL:X92686) Streptomyces coelicolor cold shock protein ScoF%2C 67 aa%2C fasta scores: opt: 408 z-score: 562.4 E(): 6.6e-24%3B 86.6%25 identity in 67 aa overlap. Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain and match to Prosite entry PS00352 'Cold-shock' DNA-binding domain signature gene gene3774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3748 SCO3749 SCO3749 SCH22A.27c SCH22A.27c 4119416 4120066 - hypothetical protein SCH22A.27c%2C possible integral membrane protein%2C len: 216 aa. Contains possible hydrophobic membrane spanning regions gene gene3775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3749 SCO3750 SCO3750 SCH22A.28c SCH22A.28c 4120212 4121462 - two-component sensor histidine kinase SCH22A.28c%2C possible two-component sensor histidine kinase%2C len: 416 aa%3B similar to SW:UHPB_SALTY (EMBL:M89480) Salmonella typhimurium sensor protein UhpB (EC 2.7.3.-)%2C 500 aa%3B fasta scores: opt: 274 z-score: 299.1 E(): 3e-09%3B 26.4%25 identity in 337 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3750 SCO3751 SCO3751 SCH22A.29 SCH22A.29 4121664 4121933 + hypothetical protein SCH22A.29%2C membrane protein%2C len: 89 aa. Contains possible hydrophobic membrane spanning regions gene gene3777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3751 SCO3752 SCO3752 SCH22A.30 SCH22A.30 4121930 4122688 + ABC transporter ATP-binding protein SCH22A.30%2C possible ABC transporter ATP-binding protein%2C len: 252 aa%3B similar to TR:Q9XAA7 (EMBL:AL096837) Streptomyces coelicolor ABC transporter ATP-binding protein SCF43A.08%2C 264 aa%3B fasta scores: opt: 848 z-score: 944.8 E(): 0%3B 56.0%25 identity in 243 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene3778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3752 SCO3753 SCO3753 SCH22A.31 SCH22A.31 4122691 4125243 + hypothetical protein SCH22A.31%2C possible integral membrane%2C len: 850 aa. Contains possible hydrophobic membrane spanning regions gene gene3779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3753 SCO3754 SCO3754 SCH22A.32c SCH22A.32c 4125465 4127978 - ABC transporter SCH63.01c%2C possible ABC transport system integral membrane protein (fragment)%2C len: >319 aa%3B similar to TR:CAB77000 (EMBL:AL159178) Streptomyces coelicolor integral membrane protein SCH22A.31%2C 850 aa%3B fasta scores: opt: 510 z-score: 493.4 E(): 5.8e-20%3B 38.1%25 identity in 315 aa overlap. Contains possible hydrophobic membrane spanning regions~SCH22A.32c%2C possible transmembrane transport protein (fragment)%2C len: >569 aa%3B similar to TR:Q9XAA6 (EMBL:AL096837) Streptomyces coelicolor transmembrane transport protein SCF43A.09 463 a%3B fasta scores: opt: 255 z-score: 268.0 E(): 1.6e-07%3B 30.4%25 identity in 415 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3754 SCO3755 SCO3755 SCH63.02c SCH63.02c 4127975 4128769 - ABC transporter ATP-binding protein SCH63.02c%2C possible ABC transport system ATP binding protein%2C len: 164 aa%3B similar to TR:CAB81857 (EMBL:AL161691) Streptomyces coelicolor ABC-transporter ATP binding protein SCD40A.12c%2C 246 aa%3B fasta scores: opt: 1007 z-score: 1087.6 E(): 0%3B 67.4%25 identity in 236 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene3781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3755 SCO3756 SCO3756 SCH63.03c SCH63.03c 4128978 4129652 - two component system response regulator SCH63.03c%2C possible two component system response regulator%2C len: 224 aa%3B similar to TR:Q9X8Q7 (EMBL:AL049754) Streptomyces coelicolor two-component system regulator SCH10.18c%2C 228 aa%3B fasta scores: opt: 827 z-score: 946.4 E(): 0%3B 62.1%25 identity in 219 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature gene gene3782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3756 SCO3757 SCO3757 SCH63.04c SCH63.04c 4129649 4130995 - two component system sensor kinase SCH63.04c%2C possible two component system sensor kinase%2C len: 448 aa%3B similar to TR:Q9X8Q6 (EMBL:AL049754) Streptomyces coelicolor two-component system sensor kinase SCH10.17c%2C 472 aa%3B fasta scores: opt: 595 z-score: 616.4 E(): 8.2e-27%3B 36.4%25 identity in 453 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3757 SCO3758 SCO3758 SCH63.05c SCH63.05c 4131008 4132060 - fatty acid desaturase SCH63.05c%2C possible fatty acid desaturase%2C len: 350 aa%3B similar to TR:Q9X8W4 (EMBL:AL078610) Streptomyces coelicolor delta fatty acid desaturase SCH35.42c%2C 345 aa%3B fasta scores: opt: 1041 z-score: 1260.0 E(): 0%3B 50.3%25 identity in 332 aa overlap and to TR:Q9SWQ9 (EMBL:AF139720) Euglena gracilis delta 8 fatty acid desaturase Efd1%2C 419 aa%3B fasta scores: opt: 421 z-score: 510.9 E(): 6.1e-21%3B 27.3%25 identity in 333 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3758 SCO3759 SCO3759 SCH63.06c SCH63.06c 4132135 4133346 - hypothetical protein SCH63.06c%2C possible integral membrane protein%2C len: 403 aa%3B similar to TR:Q9X8Q9 (EMBL:AL049754) Streptomyces coelicolor membrane protein SCH10.20c%2C 420 aa%3B fasta scores: opt: 898 z-score: 1025.8 E(): 0%3B 45.3%25 identity in 395 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3759 SCO3760 SCO3760 SCH63.07c SCH63.07c 4133355 4134332 - hypothetical protein SCH63.07c%2C possible hypothetical protein%2C len: 325 aa%3B similar to TR:Q9X8R0 (EMBL:AL049754) Streptomyces coelicolor hypothetical 33.9 kDa protein SCH10.21c%2C 329 aa%3B fasta scores: opt: 589 z-score: 637.7 E(): 5.3e-28%3B 37.5%25 identity in 328 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3760 SCO3761 SCO3761 SCH63.08c SCH63.08c 4134484 4134996 - hypothetical protein SCH63.08c%2C unknown%2C len: 170 aa gene gene3787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3761 SCO3762 SCO3762 SCH63.09c SCH63.09c 4135076 4135273 - hypothetical protein SCH63.09c%2C unknown%2C len: 65 aa gene gene3788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3762 SCO3763 SCO3763 SCH63.10c SCH63.10c 4135438 4137522 - hypothetical protein SCH63.10c%2C hypothetical protein%2C len: 694 aa%3B N-terminal region similar to SW:TERD_ALCSP (EMBL:M20238) Alcaligenes sp. tellurium resistance protein TerD (plasmid determined)%2C 192 aa%3B fasta scores: opt: 420 z-score: 446.6 E(): 2.3e-17%3B 39.8%25 identity in 186 aa overlap and C-terminal region similar to C-terminal region of TR:Q9X843 (EMBL:AL049727) Streptomyces coelicolor transferase (fragment) SC9B1.24%2C 317 aa%3B blastp scores: Score %3D 76 (26.8 bits)%2C Expect %3D 7.3%2C Sum P(2) %3D 1.0%3B Identities %3D 52/165 (31%25)%2C Positives %3D 72/165 (43%25). Contains Pfam match to entry PF02342 TerD at N-terminal region gene gene3789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3763 SCO3764 SCO3764 SCH63.11c SCH63.11c 4137713 4138738 - hypothetical protein SCH63.11c%2C possible integral membrane protein%2C len: 341 aa%3B similar to TR:CAC01476 (EMBL:AL391014) Streptomyces coelicolor integral membrane protein 2SCG1.27%2C 337 aa%3B fasta scores: opt: 1316 z-score: 1472.5 E(): 0%3B 59.9%25 identity in 337 aa overlap. Contains Pfam match to entry PF01595 DUF21%2C Domain of unknown function DUF21 and 2x match to PF00571 CBS%2C CBS domain. Also contains possible hydrophobic membrane spanning regions gene gene3790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3764 SCO3765 SCO3765 SCH63.12c SCH63.12c 4138735 4140114 - hypothetical protein SCH63.12c%2C possible integral membrane protein%2C len: 459 aa%3B similar to TR:CAC01475 (EMBL:AL391014) Streptomyces coelicolor integral membrane protein 2SCG1.26%2C 468 aa%3B fasta scores: opt: 1879 z-score: 2014.4 E(): 0%3B 67.8%25 identity in 441 aa overlap. Contains Pfam match to entry PF01595 DUF21%2C Domain of unknown function DUF21 and 2x matches to PF00571 CBS%2C CBS domain. Also contains possible hydrophobic membrane spanning regions gene gene3791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3765 SCO3766 SCO3766 SCH63.13 SCH63.13 4140307 4141329 + hypothetical protein SCH63.13%2C hypothetical protein%2C len: 340 aa%3B highly similar to TR:Q9S1P4 (EMBL:AL109972) Streptomyces coelicolor hypothetical protein SCJ9A.26%2C 341 aa%3B fasta scores: opt: 1171 z-score: 1269.9 E(): 0%3B 61.8%25 identity in 340 aa overlap gene gene3792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3766 SCO3767 SCO3767 SCH63.14 SCH63.14 4141437 4141892 + hypothetical protein SCH63.14%2C hypothetical protein%2C len: 151 aa%3B similar to plasmid encoded TR:Q52355 (EMBL:L38824) Serratia marcescens tellurite resistance protein TerB%2C plasmid R478%2C 151 aa%3B fasta scores: opt: 257 z-score: 320.7 E(): 2.4e-10%3B 26.5%25 identity in 151 aa overlap and to TR:CAC44659 (EMBL:AL596248) Streptomyces coelicolor conserved hypothetical protein SCBAC17A6.14c%2C 191 aa%3B fasta scores: opt: 588 Z-score: 695.8 E(): 4e-31%3B 65.185%25 identity in 135 aa overlap gene gene3793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3767 SCO3768 SCO3768 SCH63.15 SCH63.15 4141996 4142244 + translocase SCH63.15%2C possible translocase%2C len: 82 aa%3B similar to SW:YK94_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis hypothetical 8.9 kDa protein MTCY49.34c%2C 83 aa%3B fasta scores: opt: 123 z-score: 165.1 E(): 0.11%3B 40.6%25 identity in 69 aa overlap. Contains Pfam match to entry PF02416 MttA_Hcf106 gene gene3794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3768 SCO3769 SCO3769 SCH63.16c SCH63.16c 4142257 4142994 - TetR family transcriptional regulator SCH63.16c%2C possible tetR family transcriptional regulatory protein%2C len: 245 aa%3B similar to TR:Q9WX19 (EMBL:AL079345) Streptomyces coelicolor transcriptional regulator SCE68.13%2C 230 aa%3B fasta scores: opt: 359 z-score: 384.4 E(): 6.8e-14%3B 37.2%25 identity in 231 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 38..59 (+2.58 SD) gene gene3795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3769 SCO3770 SCO3770 SCH63.17 SCH63.17 4143070 4144254 + cytochrome P450 oxidoreductase SCH63.17%2C probable cytochrome P450 oxidoreductase%2C len: 394 aa%3B similar to SW:CPXK_SACER (EMBL:M83110) Saccharopolyspora erythraea cytochrome P450 107B1 (EC 1.14.-.-) (P450CVIIB1) Cyp107B1%2C 405 aa%3B fasta scores: opt: 1038 z-score: 1154.8 E(): 0%3B 46.9%25 identity in 373 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 and match to Prosite entry PS00211 ABC transporters family signature and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Also contains a TTA leucine codon%2C possible target for bldA regulation gene gene3796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3770 SCO3771 SCO3771 SCH63.18c SCH63.18c 4144272 4145912 - penicillin binding protein SCH63.18c%2C probable penicillin binding protein%2C len: 546 aa%3B similar to TR:P72405 (EMBL:U56256) Streptomyces clavuligerus high molecular weight group B penicillin binding protein PcbR%2C 551 aa%3B fasta scores: opt: 1063 z-score: 1122.1 E(): 0%3B 37.7%25 identity in 559 aa overlap. Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and possible N-terminal region signal peptide sequence gene gene3797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3771 SCO3772 SCO3772 SCH63.19c SCH63.19c 4145930 4146976 - hypothetical protein SCH63.19c%2C possible hypothetical protein%2C len: 348 aa%3B similar to TR:AAG03932 (EMBL:AE004490) Pseudomonas aeruginosa hypothetical 35.1 kDa protein PA0543%2C 322 aa%3B fasta scores: opt: 419 z-score: 410.9 E(): 2.3e-15%3B 33.6%25 identity in 295 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3772 SCO3773 SCO3773 SCH63.20 SCH63.20 4147062 4148024 + LysR family transcriptional regulator SCH63.20%2C probable lysR family transcriptional regulatory protein%2C len: 320 aa%3B similar to SW:ALSR_BACSU (EMBL:L04470) Bacillus subtilis Als operon regulatory protein AlsR%2C 302 aa%3B fasta scores: opt: 463 z-score: 517.7 E(): 3e-21%3B 30.4%25 identity in 260 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Also contains possible helix-turn-helix motif at residues 17..38 (+2.87 SD) gene gene3799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3773 SCO3774 SCO3774 SCH63.21 SCH63.21 4148686 4149564 + beta-lactamase SCH63.21%2C possible beta-lactamase related protein%2C len: 292 aa%3B similar to SW:BLAB_STRCI (EMBL:D00937) Streptomyces cacaoi beta-lactamase regulatory protein BlaB%2C 312 aa%3B fasta scores: opt: 225 z-score: 271.2 E(): 1.4e-07%3B 34.6%25 identity in 301 aa overlap gene gene3800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3774 SCO3775 SCO3775 SCH63.22c SCH63.22c 4149589 4151322 - hypothetical protein SCH63.22c%2C unknown%2C len: 577 aa. High content in glycine and alanine amino acid residues gene gene3801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3775 SCO3776 SCO3776 SCH63.23 SCH63.23 4151301 4151843 + hypothetical protein SCH63.23%2C possible membrane protein%2C len: 180 aa. Contains possible hydrophobic membrane spanning region and 3x degenerate repeat: DTG(T/A). Also contains a TTA leucine codon%2C possible target for bldA regulation gene gene3802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3776 SCO3777 SCO3777 SCH63.24 SCH63.24 4151848 4152975 + peptidase SCH63.24%2C probable peptidase%2C len: 375 aa%3B similar to SW:PEPQ_LACDL (EMBL:Z34896) Lactobacillus delbrueckii XAA-PRO dipeptidase (EC 3.4.13.9) PepQ%2C 368 aa%3B fasta scores: opt: 623 z-score: 715.2 E(): 2.6e-32%3B 32.1%25 identity in 365 aa overlap and to TR:CAB41569 (EMBL:AL049727) Streptomyces coelicolor dipeptidase SC9B1.23%2C 376 aa%3B fasta scores: opt: 1608 z-score: 1515.1 E(): 0%3B 63.5%25 identity in 373 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24%2C metallopeptidase family M24 gene gene3803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3777 SCO3778 SCO3778 SCH63.25 SCH63.25 4153150 4154442 + threonyl tRNA synthetase SCH63.25%2C possible threonyl tRNA synthetase%2C len: 430 aa%3B highly similar to C-terminal region of many threonyl tRNA synthetases%2C e.g. SW:SYT1_BACSU (EMBL:M36594) Bacillus subtilis threonyl tRNA synthetase 1 (EC 6.1.1.3) ThrS%2C 643 aa%3B fasta scores: opt: 1274 z-score: 1489.5 E(): 0%3B 50.9%25 identity in 379 aa overlap. Contains Pfam match to entry PF00587 tRNA-synt_2b%2C tRNA synthetase class II (G%2C H%2C P%2C S and T) gene gene3804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3778 SCO3779 SCO3779 SCH63.26 SCH63.26 4154591 4155571 + nucleoside hydrolase SCH63.26%2C probable nucleoside hydrolase%2C len: 326 aa%3B similar to SW:IUNH_CRIFA (EMBL:U43371) Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) IunH%2C 314 aa%3B fasta scores: opt: 634 z-score: 671.5 E(): 6.9e-30%3B 35.0%25 identity in 320 aa overlap. Contains Pfam match to entry PF01156 IU_nuc_hydro%2C Inosine-uridine preferring nucleoside hydrolase gene gene3805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3779 SCO3780 SCO3780 SCH63.27 SCH63.27 4155682 4157352 + sugar hydrolase SCH63.27%2C probable sugar hydrolase%2C len: 556 aa%3B similar to SW:TREC_ECOLI (EMBL:U06195) Escherichia coli trehalose-6-phosphate hydrolase (EC 3.2.1.93) TreC%2C 551 aa%3B fasta scores: opt: 833 z-score: 927.7 E(): 0%3B 35.4%25 identity in 557 aa overlap and to TR:CAB90876 (EMBL:AL355753) Streptomyces coelicolor aglA%2C alpha-glucosidase SC10B7.23c%2C 577 aa%3B fasta scores: opt: 1146 z-score: 1084.7 E(): 0%3B 56.8%25 identity in 572 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene3806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3780 SCO3781 SCO3781 SCH63.28 SCH63.28 4157484 4158338 + hypothetical protein SCH63.28%2C possible hypothetical protein%2C len: 284 aa%3B similar to TR:CAB89024 (EMBL:AL353870) Streptomyces coelicolor lipoprotein SC6F7.16c%2C 281 aa%3B fasta scores: opt: 467 z-score: 500.3 E(): 2.4e-20%3B 39.7%25 identity in 277 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene3807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3781 SCO3782 SCO3782 SCH63.29c SCH63.29c 4158580 4159929 - regulatory protein SCH63.29c%2C possible regulatory protein%2C len: 449 aa%3B similar to TR:O86603 (EMBL:AL031155) Streptomyces coelicolor transcriptional regulator SC3A7.02c%2C 892 aa%3B blastp scores: Score %3D 148 (52.1 bits)%2C Expect %3D 6.7e-07%2C P %3D 6.7e-07%3B Identities %3D 98/317 (30%25)%2C Positives %3D 130/317 (41%25). Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and 4x matches to entry PF00515 TPR%2C TPR Domain gene gene3808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3782 SCO3783 SCO3783 SCH63.30 SCH63.30 4160042 4160218 + lipoprotein SCH63.30%2C possible lipoprotein%2C len: 58 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene3809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3783 SCO3784 SCO3784 SCH63.31c SCH63.31c 4160268 4161347 - hypothetical protein SCH63.31c%2C unknown%2C len: 359 aa. High content in alanine%2C leucine and arginine amino acid residues. Also high content in G+C (79.48%25) gene gene3810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3784 SCO3785 SCO3785 SCH63.32c SCH63.32c 4161431 4162660 - hypothetical protein SCH63.32c%2C possible integral membrane protein%2C len: 409 aa%3B similar to TR:CAB95784 (EMBL:AL359949) Streptomyces coelicolor integral membrane protein 2SCG61.09%2C 387 aa%3B fasta scores: opt: 464 z-score: 500.7 E(): 2.3e-20%3B 32.5%25 identity in 379 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3785 SCO3786 SCO3786 SCH63.33 SCH63.33 4162785 4163303 + hypothetical protein SCH63.33%2C possible integral membrane protein%2C len: 172 aa%3B low similarity to TR:O86915 (EMBL:Y15759) Streptomyces rochei ORFA protein (fragment)%2C 128 aa%3B fasta scores: opt: 221 z-score: 269.8 E(): 1.6e-07%3B 33.0%25 identity in 109 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3786 SCO3787 SCO3787 SCH63.34 SCH63.34 4163376 4164320 + hypothetical protein SCH63.34%2C possible integral membrane protein%2C len: 314 aa. Contains possible hydrophobic membrane spanning regions gene gene3813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3787 SCO3788 SCO3788 SCH63.35 SCH63.35 4164327 4164737 + hypothetical protein SCH63.35%2C unknown%2C len: 136 aa%3B similar to TR:Q98LX4 (EMBL:AP002995) hypothetical protein from Rhizobium loti (Mesorhizobium loti) (71 aa) fasta scores%3B 78.689%25 identity (78.689%25 ungapped) in 61 aa overlap. gene gene3814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3788 SCO3789 SCO3789 SCH63.36 SCH63.36 4164773 4165789 + hypothetical protein SCH63.36%2C possible integral membrane protein%2C len: 338 aa%3B similar to TR:Q9RS34 (EMBL:AE002061) Deinococcus radiodurans conserved hypothetical protein DR2293%2C 322 aa%3B fasta scores: opt: 233 z-score: 262.7 E(): 4.1e-07%3B 34.9%25 identity in 304 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3789 SCO3790 SCO3790 SCH63.37c SCH63.37c 4165816 4167894 - hypothetical protein SCH63.37c%2C conserved hypothetical protein%2C len: 693 aa%3B similar to TR:AAF95947 (EMBL:AE004347) Vibrio cholerae hypothetical 68.9 kDa protein VCA0033%2C 624 aa%3B fasta scores: opt: 936 z-score: 990.2 E(): 0%3B 39.4%25 identity in 670 aa overlap gene gene3816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3790 SCO3791 SCO3791 SCH63.38 SCH63.38 4168158 4169495 + hypothetical protein SCH63.38%2C hypothetical protein%2C len: 445 aa%3B C-terminal region similar to TR:Q9S2I1 (EMBL:AL109732) Streptomyces coelicolor hypothetical protein SC7H2.36c%2C 252 aa%3B fsta scores: opt: 620 Z-score: 451.7 E(): 1.6e-17%3B 45.175%25 identity in 228 aa overlap gene gene3817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3791 SCO3792 SCO3792 SCH63.39 SCH63.39 4169611 4171227 + methionyl-tRNA synthetase methionine--tRNA ligase%3B MetRS%3B adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate%3B some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not%3B four subfamilies exist based on sequence motifs and zinc content gene gene3818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3792 SCO3793 SCO3793 SCAC2.01 SCAC2.01 4171328 4171693 + hypothetical protein SCAC2.01%2C conserved hypothetical protein%2C len: 121 aa%3B similar to TR:O34593 (EMBL:Z99110) Bacillus subtilis YjqA protein%2C 125 aa%3B fasta scores: opt: 459 z-score: 636.3 E(): 6.2e-28%3B 60.5%25 identity in 114 aa overlap gene gene3819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3793 SCO3794 SCO3794 SCAC2.02c SCAC2.02c 4171889 4172662 - glycosyl transferase SCAC2.02c%2C probable glycosyl transferase%2C len: 257 aa%3B similar to TR:BAB07380 (EMBL:AP001519) Bacillus halodurans teichuronic acid biosynthesis TuaG%2C 257 aa%3B fasta scores: opt: 624 z-score: 745.5 E(): 0%3B 41.3%25 identity in 252 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene3820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3794 SCO3795 SCO3795 aspS aspS 4172747 4174510 - aspartyl-tRNA synthetase catalyzes a two-step reaction%2C first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B contains discriminating and non-discriminating subtypes gene gene3821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3795 SCO3796 SCO3796 SCAC2.04 SCAC2.04 4174717 4176885 + hypothetical protein SCAC2.04%2C hypothetical protein%2C len: 722 aa%3B similar to TR:Q9RIW0 (EMBL:AL133278) Streptomyces coelicolor hypothetical 64.1 kDa protein (fragment) SCM11.01c%2C 588 aa%3B fasta scores: opt: 1053 z-score: 1177.1 E(): 0%3B 35.8%25 identity in 598 aa overlap gene gene3822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3796 SCO3797 SCO3797 SCAC2.05c SCAC2.05c 4176813 4177901 - hypothetical protein SCAC2.05c%2C possible integral membrane protein%2C len: 362 aa%3B similar to TR:O53656 (EMBL:AL021928) Mycobacterium tuberculosis hypothetical 38.0 kDa protein MTV033.13%2C 367 aa%3B fasta scores: opt: 586 z-score: 618.4 E(): 6.1e-27%3B 34.8%25 identity in 325 aa overlap. Contains Pfam match to entry PF01594 UPF0118%2C Domain of unknown function DUF20 and possible hydrophobic membrane spanning regions gene gene3823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3797 SCO3798 SCO3798 SCAC2.06c SCAC2.06c 4177967 4178944 - chromosome condensation protein SCAC2.06c%2C possible chromosome condensation protein%2C len: 325 aa%3B similar to many eukaryote Pirin-like proteins%2C e.g. TR:O00625 (EMBL:Y07868) Homo sapiens Pirin%2C 290 aa%3B fasta scores: opt: 353 z-score: 412.8 E(): 1.7e-15%3B 38.6%25 identity in 277 aa overlap. Contains match to Prosite entry PS00626 Regulator of chromosome condensation (RCC1) signature 2 and the actinophage PhiC31 left and right junctions attachment site%2C attB gene gene3824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3798 SCO3799 SCO3799 SCAC2.07c SCAC2.07c 4179065 4179535 - hypothetical protein SCAC2.07c%2C unknown%2C len: 156 aa gene gene3825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3799 SCO3800 SCO3800 SCAC2.08 SCAC2.08 4179684 4181510 + acyl-CoA dehydrogenase SCGD3.01%2C possible acyl-CoA dehydrogenase%2C partial CDS%2C len: >491 aa%3B weakly similar to TR:P97088 (EMBL:Z92974)%2C bcd%2C Clostridium thermosaccharolyticum butyryl-CoA dehydrogenase (379 aa)%2C fasta scores%3B opt: 176 z-score: 203.7 E(): 0.00051%2C 28.0%25 identity in 318 aa overlap. Also highly similar to acyl-CoA dehydrogenases from mycobacteria e.g. TR:O69506 (EMBL:AL022486) Mycobacterium leprae probable acyl-CoA dehydrogenase (611 aa) (64.3%25 identity in 493 aa overlap). Contains two Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase~SCAC2.08%2C possible dehydrogenase (fragment)%2C len: >149 aa%3B similar to N-terminal region of TR:O53666 (EMBL:AL021929%3B) Mycobacterium tuberculosis acyl-CoA dehydrogenase MTV034.10c%2C 611 aa%3B fasta scores: opt: 547 z-score: 662.5 E(): 2.1e-29%3B 52.4%25 identity in 147 aa overlap gene gene3826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3800 SCO3801 SCO3801 SCGD3.02 SCGD3.02 4181609 4182907 + aminopeptidase 2 catalyzes the removal of amino acids from the N termini of peptides gene gene3827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3801 SCO3802 SCO3802 SCGD3.03 SCGD3.03 4183022 4183273 + hypothetical protein SCGD3.03%2C possible membrane protein%2C len: 83 aa%3B probable CDS suggested by probable CDS suggested by positional base preference%2C GC frame analysis and the presence of a possible RBS. Hydrophobic%2C apart from the C-terminal region gene gene3828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3802 SCO3803 SCO3803 SCGD3.04c SCGD3.04c 4183333 4183737 - hypothetical protein SCGD3.04c%2C hypothetical protein%2C len: 134 aa%3B shows similarity to TR:P96597 (EMBL:AB001488)%2C YdbB%2C Bacillus subtilis hypothetical protein (113 aa)%2C fasta scores%3B E(): 2.8e-05%2C 35.6%25 identity in 87 aa overlap and to hypothetical proteins from Neisseria meningitidis serogroup A%2C e.g. NMA0576%2C hypothetical protein (107 aa)%2C blastp scores: Expect%3D 4.6e-11. Probable member of the cupin superfamily gene gene3829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3803 SCO3804 SCO3804 SCGD3.05 SCGD3.05 4183789 4184793 + AraC family transcription regulator SCGD3.05%2C probable araC-family transcriptional regulator%2C len: 334 aa%3B probable araC-type regulator similar to many e.g. TR:O30507 (EMBL:AF008308)%2C ArgR%2C Pseudomonas aeruginosa arginine regulatory protein (328 aa)%2C fasta scores%3B opt: 398 z-score: 463.6 E(): 1.7e-18%2C 30.8%25 identity in 334 aa overlap. Similar to others from S.coelicolor e.g. (EMBL:AL049587)%2C SC5F2A.29%2C S.coelicolor possible transcriptional regulator (325 aa) (37.6%25 identity in 314 aa overlap). Contains probable helix-turn-helix motif at aa 240-261 (Score 1477%2C +4.22 SD). A second%2C less probable motif is at aa 305-326 (Score 1090%2C +2.90 SD). Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family gene gene3830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3804 SCO3805 SCO3805 SCGD3.06 SCGD3.06 4184790 4185284 + hypothetical protein SCGD3.06%2C hypothetical protein%2C len: 164 aa%3B unknown function%2C weakly similar to TR:P94352 (EMBL:D83026) Bacillus subtilis hypothetical protein (162 aa)%2C fasta scores%3B opt: 185 z-score: 240.2 E(): 4.7e-06%2C 21.8%25 identity in 165 aa overlap. An alternative start codon is present at codon 5 gene gene3831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3805 SCO3806 SCO3806 SCGD3.07c SCGD3.07c 4185307 4185765 - hypothetical protein SCGD3.07c%2C hypothetical protein%2C len: 152 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by positional base preference and GC frame analysis gene gene3832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3806 SCO3807 SCO3807 SCGD3.08c SCGD3.08c 4185833 4186627 - hydrolase SCGD3.08c%2C possible hydrolase%2C len: 264 aa%3B weakly similar to hydrolases e.g. to TR:Q44185 (EMBL:X91070) Agrobacterium radiobacter D-N-alpha-carbamilase (304 aa) (28.17%25 identity in 252 aa overlap). Similar to many hypothetical proteins e.g. TR:O27839 (EMBL:AE000934) Methanobacterium thermoautotrophicum N-carbamoyl-D-amino acid amidohydrolase (272 aa) (36.2%25 identity in 265 aa overlap). Similar to others from S.coelicolor e.g. TR:O69808 (EMBL:AL023496) S.coelicolor possible hydrolase (280 aa) (31.7%25 identity in 281 aa overlap). An alternative start codon is present at codon 10. Contains PS01227 Uncharacterized protein family UPF0012 signature which is also present in many of the hypothetical proteins similar to this one gene gene3833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3807 SCO3808 SCO3808 SCGD3.09 SCGD3.09 4186809 4187633 + hypothetical protein SCGD3.09%2C hypothetical protein%2C len: 274 aa%3B unknown function%2C similar to TR:O05777 (EMBL:Z95150) Mycobacterium tuberculosis hypothetical protein (283 aa)%2C fasta scores%3B opt: 384 z-score: 466.0 E(): 1.3e-18%2C 32.7%25 identity in 269 aa overlap gene gene3834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3808 SCO3809 SCO3809 SCGD3.10c SCGD3.10c 4187758 4189068 - transmembrane transport protein SCGD3.10c%2C probable transmembrane transport protein%2C len: 436 aa%3B similar to several hypothetical transporters and weakly similar to TR:O54041 (EMBL:Y15252)%2C narK1%2C Pseudomonas aeruginosa nitrate extrusion protein (341 aa)%2C fasta scores%3B opt: 243 z-score: 275.0 E(): 5.5e-08%2C 24.9%25 identity in 422 aa overlap. Weakly similar to many from S.coelicolor e.g. (EMBL:AL034443)%2C SC4B5.13%2C probable integral membrane transporter (446 aa) (24.6%25 identity in 345 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter gene gene3835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3809 SCO3810 SCO3810 SCGD3.11c SCGD3.11c 4189065 4189715 - GntR family transcriptional regulator SCGD3.11c%2C probable gntR-family transcriptional regulator%2C len: 216 aa%3B similar to many e.g. SW:GNTR_BACSU (EMBL:J02584)%2C GntR%2C Bacillus subtilis gluconate operon transcriptional repressor (243 aa)%2C fasta scores%3B opt: 228 z-score: 274.3 E(): 5.9e-08%2C 28.5%25 identity in 186 aa overlap. Also similar to others from S.coelicolor (EMBL:AL034443) S.coelicolor probable transcriptional regulator (225 aa) (33.6%25 identity in 214 aa overlap). Contains probable helix-turn-helix motif at aa 34-55 (Score 991%2C +2.56 SD). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and PS00043 Bacterial regulatory proteins%2C gntR family signature gene gene3836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3810 SCO3811 SCO3811 dacA dacA 4189937 4190881 + D-alanyl-D-alanine carboxypeptidase SCGD3.12%2C dacA%2C probable D-alanyl-D-alanine carboxypeptidase%2C len: 314 aa%3B highly similar to SW:DACX_STRSK (EMBL:X59965) Streptomyces sp. (strain K15) D-alanyl-D-alanine carboxypeptidase (291 aa)%2C fasta scores%3B opt: 1322 z-score: 1435.8 E(): 0%2C 73.8%25 identity in 302 aa overlap. Also similar to many other penicillin-binding proteins. Contains Pfam match to entry PF00768 Peptidase_S11%2C D-alanyl-D-alanine carboxypeptidase and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible hydrophobic membrane spanning region gene gene3837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3811 SCO3812 SCO3812 SCGD3.13 SCGD3.13 4190999 4191346 + GntR family transcriptional regulator SCGD3.13%2C probable gntR-family transcriptional regulator%2C len: 115 aa%3B weakly similar to several transcriptional regulators e.g. to the N-terminal half of TR:O70026 (EMBL:X80774)%2C traR%2C transcriptional repressor of TraB from Streptomyces ghanaensis plasmid pSG5 (246 aa)%2C fasta scores%3B opt: 173 z-score: 224.1 E(): 3.7e-05%2C 35.6%25 identity in 87 aa overlap. Similar to TR:O34712 (EMBL:AF008220) Bacillus subtilis transcription regulator (130 aa) (28.2%25 identity in 117 aa overlap). Weakly similar to many from S.coelicolor e.g. (EMBL:AL049573)%2C SCE39.19%2C possible gntR-family regulator (251 aa) (37.1%25 identity in 97 aa overlap). Contains probable helix-turn-helix motif at aa 38-59 (Score 1394%2C +3.93 SD). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene3838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3812 SCO3813 SCO3813 SCGD3.14 SCGD3.14 4191343 4192329 + hypothetical protein SCGD3.14%2C possible membrane protein%2C len: 328 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by positional base preference and GC frame analysis. Contains hydrophobic%2C possible membrane-spanning regions gene gene3839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3813 SCO3814 SCO3814 SCGD3.15 SCGD3.15 4192477 4193454 + DNA-binding protein SCGD3.15%2C possible DNA-binding protein%2C len: 325 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by positional base preference%2C GC frame analysis%2C amino acid composition and the presence of a possible RBS. Possible DNA-binding function as it contains a probable helix-turn-helix motif at aa 279-300 (Score 1121%2C +3.00 SD) gene gene3840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3814 SCO3815 SCO3815 bkdC1 bkdC1 4193532 4194941 - branched-chain alpha-keto acid dehydrogenase E2 SCGD3.16c%2C bkdC1%2C probable dihydrolipoamide acyltransferase component E2%2C len: 469 aa%3B similar to many e.g. SW:ODP2_BACST (EMBL:X53560) Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (427 aa)%2C fasta scores%3B opt: 733 z-score: 672.8 E(): 3.8e-30%2C 38.7%25 identity in 460 aa overlap. Highly similar to SCGD3.30c%2C probable dihydrolipoamide acyltransferase component E2 (491 aa) (40.1%25 identity in 494 aa overlap)%2C in a duplication of this region upstream. Contains Pfam matches to entry PF00198 2-oxoacid_dh%2C 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and to entry PF00364 biotin_req_enzy%2C Biotin-requiring enzymes. Contains PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site gene gene3841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3815 SCO3816 SCO3816 bkdB1 bkdB1 4194961 4195941 - branched-chain alpha-keto acid dehydrogenase E1 subunit beta SCGD3.17c%2C bkdB1%2C probable branched-chain alpha keto acid dehydrogenase E1 beta subunit%2C len: 326 aa%3B similar to E1 beta subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53593 (EMBL:U1716)%2C BkdB%2C Streptomyces avermitilis E1-beta branched-chain alpha keto acid dehydrogenase (334 aa)%2C fasta scores%3B opt: 1188 z-score: 1395.2 E(): 0%2C 53.8%25 identity in 325 aa overlap and SW:ODPB_BACST (EMBL:X53560)%2C PdhB%2C Bacillus stearothermophilus pyruvate dehydrogenase complex E1 beta subunit (324 aa) (48.0%25 identity in 323 aa overlap). Highly similar to SCGD3.31c%2C probable dihydrolipoamide acyltransferase component E2 (334 aa) (55.2%25 identity in 324 aa overlap)%2C in a duplication of this region upstream gene gene3842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3816 SCO3817 SCO3817 bkdA1 bkdA1 4195943 4197196 - branched-chain alpha-keto acid dehydrogenase E1 subunit alpha SCGD3.18c%2C bkdA1%2C probable branched-chain alpha keto acid dehydrogenase E1 alpha subunit%2C len: 417 aa%3B similar to E1 alpha subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53610 (EMBL:U26308) Streptomyces avermitilis branched-chain alpha-keto acid dehydrogenase E1-alpha subunit (406 aa)%2C fasta scores%3B opt: 2177 z-score: 2466.3 E(): 0%2C 80.9%25 identity in 409 aa overlap and SW:ODPA_BACST (EMBL:X53560)%2C PdhA%2C Bacillus stearothermophilus pyruvate dehydrogenase complex E1 alpha subunit (368 aa) (39.7%25 identity in 325 aa overlap). Similar to SCGD3.32c%2C probable branched-chain alpha keto acid E1 alpha subunit%2C partial CDS (179 aa) (38.8%25 identity in 165 aa overlap)%2C in a duplication of this region upstream. Contains Pfam match to entry PF00676 E1_dehydrog%2C Dehydrogenase E1 component gene gene3843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3817 SCO3818 SCO3818 SCGD3.19 SCGD3.19 4197520 4198176 + two-component system response transcriptional regulator SCGD3.19%2C probable two-component system transcriptional regulator%2C len: 218 aa%3B similar to many two-component system regulators e.g. TR:O85372 (EMBL:AF064700)%2C CprR%2C Rhodococcus sp. two-component system component controlling expression of an emulsion-stabilizing capsule (212 aa)%2C fasta scores%3B opt: 807 z-score: 938.9 E(): 0%2C 60.7%25 identity in 211 aa overlap%2C but doesn't have a directly adjacent sensor kinase. Similar to many from S.coelicolor e.g. (EMBL:AL049754)%2C SCH10.18c%2C probable two-component system regulator (228 aa) (42.2%25 identity in 211 aa overlap). Contains probable helix-turn-helix motif at aa 172-193 (Score 1200%2C +3.27 SD). Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain and to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature gene gene3844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3818 SCO3819 SCO3819 SCGD3.20 SCGD3.20 4198301 4198708 + hypothetical protein SCGD3.20%2C hypothetical protein%2C len: 135 aa%3B unknown function%2C probable CDS suggested by probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3819 SCO3820 SCO3820 SCGD3.21c SCGD3.21c 4198795 4200363 - Ser/Thr protein kinase SCGD3.21c%2C probable Ser/Thr protein kinase%2C len: 522 aa%3B similar to many e.g. (EMBL:AF094711)%2C PksC%2C Streptomyces coelicolor Ser/Thr protein kinase (556 aa)%2C fasta scores%3B opt: 907 z-score: 635.3 E(): 4.6e-28%2C 36.6%25 identity in 558 aa overlap%2C which lies upstream%2C on the opposite strand. Similar to mycobacterial Ser/Thr protein kinases%2C but divergent at the C-terminal end e.g. TR:P71584 (EMBL:Z80233)%2C PknB%2C Mycobacterium tuberculosis Ser/Thr protein kinase (626 aa) (42.3%25 identity in 437 aa overlap). Contains a hydrophobic%2C possible membrane-spannig region. C-terminal region contains 5x DPTG repeats followed by 3x GG(E/D)PTG repeats. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain%2C PS00108 Ser/Thr protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature gene gene3846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3820 SCO3821 SCO3821 pksC pksC 4200767 4202437 + Ser/Thr protein kinase SCGD3.22%2C pksC%2C Ser/Thr protein kinase%2C len: 556 aa%3B previously sequenced as (EMBL:AF094711)%2C PksC%2C Streptomyces coelicolor Ser/Thr protein kinase (556 aa). Highly similar to SCGD3.21c which lies upstream%2C on the opposite strand. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain%2C PS00108 Ser/Thr protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature gene gene3847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3821 SCO3822 SCO3822 SCGD3.23c SCGD3.23c 4202553 4203092 - hypothetical protein SCGD3.23c%2C conserved hypothetical protein%2C len: 179 aa%3B unknown function%2C highly similar to SW:Y0GE_MYCTU (EMBL:Z80343) Mycobacterium tuberculosis hypothetical protein (178 aa)%2C fasta scores%3B opt: 692 z-score: 731.2 E(): 0%2C 65.9%25 identity in 170 aa overlap gene gene3848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3822 SCO3823 SCO3823 SCGD3.24c SCGD3.24c 4204101 4205081 - quinone oxidoreductase SCGD3.24c%2C probable quinone oxidoreductase%2C len: 326 aa%3B similar to eukaryotic quinone oxidoreductases (some ) e.g. SW:QOR_CAVPO (EMBL:M26936) Cavia porcellus zeta-crystallin/quinone reductase (329 aa)%2C fasta scores%3B opt: 565 z-score: 588.2 E(): 2e-25%2C 32.6%25 identity in 328 aa overlap. Highly similar to TR:O65423 (EMBL:AL022603) Arabidopsis thaliana NADPH quinone oxidoreductase (325 aa) (57.2%25 identity in 325 aa overlap). Similar to SCE68.12c%2C S.coelicolor possible dehydrogenase (318 aa) (31.1%25 identity in 325 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene3849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3823 SCO3824 SCO3824 SCGD3.25 SCGD3.25 4205224 4206252 + ABC transporter ATP-binding protein SCGD3.25%2C probable ABC-transporter ATP-binding component%2C len: 342 aa%3B may be involved in antibiotic resistance by acting as an efflux pump%2C highly similar to to many ABC-tranporter ATP-binding components (especially those involved in antibiotic transport) e.g. TR:O86916 (EMBL:Y15759) Streptomyces rochei ABC-tranporter which induces multidrug resistance (363 aa)%2C fasta scores%3B opt: 1635 z-score: 1717.7 E(): 0%2C 77.6%25 identity in 340 aa overlap. Similar to many from S.coelicolor e.g. (EMBL:AL049841)%2C SCE9.25c%2C S.coelicolor probable ABC transporter ATP-binding component (315 aa) (53.2%25 identity in 310 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C score 192.70%2C PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3824 SCO3825 SCO3825 SCGD3.26 SCGD3.26 4206249 4207097 + ABC-transporter transmembrane protein SCGD3.26%2C probable ABC-transporter transmembrane component%2C len: 282 aa%3B may be involved in antibiotic resistance by acting as an efflux pump%2C highly similar to to many ABC-tranporter transmembrane components (especially those involved in antibiotic transport) e.g. TR:O86917 (EMBL:Y15759) Streptomyces rochei ABC-tranporter which induces multidrug resistance (284 aa)%2C fasta scores%3B opt: 1491 z-score: 1785.3 E(): 0%2C 77.5%25 identity in 284 aa overlap. Similar to many from S.coelicolor e.g. (EMBL:AL049841)%2C SCE9.24c%2C S.coelicolor probable ABC transporter transmembrane component (260 aa) (35.0%25 identity in 254 aa overlap). Contains hydrophobic%2C probable membrane-spanning regions. Contains PS00890 ABC-2 type transport system integral membrane proteins signature gene gene3851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3825 SCO3826 SCO3826 SCGD3.27c SCGD3.27c 4207170 4208267 - ion channel membrane protein SCGD3.27c%2C possible membrane protein%2C len: 365 aa%3B unknown function%2C weakly similar to C-terminal half of SW:KEFC_ECOLI (EMBL:X56742)%2C KefC%2C Escherichia coli glutathione-regulated potassium-efflux system protein (620 aa)%2C fasta scores%3B opt: 164 z-score: 190.7 E(): 0.0027%2C 21.4%25 identity in 308 aa overlap. Highest similarity to TR:O53346 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical protein (355 aa) (49.8%25 identity in 325 aa overlap). Also weakly similar to C-terminal half of SC66T3.20%2C S.coelicolor possible membrane protein (623 aa) (24.6%25 identity in 329 aa overlap) and shares regions of local similarity with other S.coelicolor membrane proteins. Contains hydrophobic%2C possible membrane-spanning regions gene gene3852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3826 SCO3827 SCO3827 SCGD3.28c SCGD3.28c 4208264 4209661 - molybdenum cofactor biosynthesis protein SCGD3.28c%2C probable molybdenum cofactor biosynthesis protein%2C len: 465 aa%3B similar to many e.g. SW:MOEA_ECOLI (EMBL:M21151)%2C moeA%2C Escherichia coli molybdenum cofactor biosynthesis protein (411 aa)%2C fasta scores%3B opt: 481 z-score: 484.8 E(): 1.1e-19%2C 32.9%25 identity in 331 aa overlap. This sequence is some 50 aa longer than many other predicted moeA homologues. The position of the start codon is suggested by the GC frameplot in this region. Contains Pfam match to entry PF00994 MoCF_biosynth%2C Molybdenum cofactor biosynthesis protein gene gene3853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3827 SCO3828 SCO3828 SCGD3.29c SCGD3.29c 4209661 4210572 - molybdopterin-guanine dinucleotide biosynthesis protein SCGD3.29c%2C possible molybdopterin-guanine dinucleotide biosynthesis protein%2C len: 303 aa%3B the N-terminal 150 aa is similar to several molybdenum cofactor biosynthesis proteins e.g. SW:MOBA_ECOLI (EMBL:L19201)%2C mobA%2C Escherichia coli molybdopterin-guanine dinucleotide biosynthesis protein A (194 aa)%2C fasta scores%3B opt: 175 z-score: 202.5 E(): 0.0006%2C 32.7%25 identity in 150 aa overlap gene gene3854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3828 SCO3829 SCO3829 bkdC2 bkdC2 4210796 4212271 - branched-chain alpha-keto acid dehydrogenase E2 SCGD3.30c%2C bkdC2%2C probable dihydrolipoamide acyltransferase component E2%2C len: 491 aa%3B similar to many e.g. SW:ODP2_BACST (EMBL:X53560) Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (427 aa)%2C fasta scores%3B opt: 672 z-score: 634.2 E(): 5.4e-28%2C 33.2%25 identity in 482 aa overlap. Highly similar to SCGD3.16c%2C probable dihydrolipoamide acyltransferase component E2 (469 aa) (40.0%25 identity in 492 aa overlap)%2C in a duplication of this region downstream. Contains Pfam matches to entry PF00198 2-oxoacid_dh%2C 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and to entry PF00364 biotin_req_enzy%2C Biotin-requiring enzymes gene gene3855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3829 SCO3830 SCO3830 bkdB2 bkdB2 4212271 4213275 - branched-chain alpha-keto acid dehydrogenase E1 subunit beta SCGD3.31c%2C bkdB2%2C probable branched-chain alpha keto acid dehydrogenase E1 beta subunit%2C len: 334 aa%3B similar to E1 beta subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53593 (EMBL:U1716)%2C BkdB%2C Streptomyces avermitilis E1-beta branched-chain alpha keto acid dehydrogenase (334 aa)%2C fasta scores%3B opt: 2063 z-score: 2427.3 E(): 0%2C 91.0%25 identity in 334 aa overlap and SW:ODPB_BACST (EMBL:X53560)%2C PdhB%2C Bacillus stearothermophilus pyruvate dehydrogenase complex E1 beta subunit (324 aa) (45.5%25 identity in 319 aa overlap). Highly similar to SCGD3.17c%2C probable branched-chain alpha keto acid dehydrogenase E1 beta subunit (326 aa) (55.2%25 identity in 324 aa overlap)%2C in a duplication of this region downstream gene gene3856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3830 SCO3831 SCO3831 bkdA2 bkdA2 4213272 4214438 - E1-alpha branched-chain alpha keto acid dehydrogenase SCGD3.32c%2C bkdA2%2C probable branched-chain alpha keto acid dehydrogenase E1 alpha subunit%2C partial CDS%2C len: >179 aa%3B similar to E1 alpha subunits from pyruvate dehydrogenase complexes and branched-chain alpha keto acid dehydrogenases e.g. TR:Q53592 (EMBL:U17169)%2C BkdA%2C Streptomyces avermitilis branched-chain alpha-keto acid dehydrogenase E1-alpha subunit (381 aa)%2C fasta scores%3B opt: 987 z-score: 1131.6 E(): 0%2C 90.3%25 identity in 165 aa overlap and SW:ODPA_ACHLA (EMBL:M81753)%2C PdhA%2C Acholeplasma laidlawii pyruvate dehydrogenase E1 component%2C alpha subunit (345 aa) (34.6%25 identity in 162 aa overlap). Similar to SCGD3.18c%2C probable branched-chain alpha keto acid E1 alpha subunit (417 aa) (38.8%25 identity in 165 aa overlap)%2C in a duplication of this region downstream. Contains probable coiled-coil from 148 to 176 (29 residues) (Max score: 1.437%2C probability 0.84)~SCH69.01c%2C bkdA2%2C E1-alpha branched-chain alpha keto acid dehydrogenase%2C len: >261aa%3B very similar to the first 261 aa of TR:Q53592 (EMBL:U17169) BkdA%2C E1-alpha branched-chain alpha keto acid dehydrogenase from Streptomyces avermitilis (381 aa) fasta scores%3B opt: 1602%2C z-score: 1786.0%2C E(): 0%2C (90.8%25 identity in 261 aa overlap). Contains Pfam match to entry PF00676 E1_dehydrog%2C Dehydrogenase E1 component. gene gene3857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3831 SCO3832 SCO3832 SCH69.02 SCH69.02 4214734 4215141 + transcriptional regulator SCH69.02%2C possible transcriptional regulator%2C len: 135 aa%3B similar to many e.g. SW:LRP_ECOLI leucine-responsive regulatory protein from Escherichia coli (163 aa) fasta scores%3B opt: 181%2C z-score: 249.4%2C E(): 1.5e-06%2C (29.5%25 identity in 129 aa overlap). Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and a probable helix-turn-helix 9-30 aa (+3.69 SD) gene gene3858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3832 SCO3833 SCO3833 SCH69.03c SCH69.03c 4215177 4215806 - transcriptional regulator SCH69.03c%2C possible transcriptional regulator%2C len: 209 aa%3B similar to many e.g. TR:AAD13556 (EMBL:AF080235) LanK regulator from the landomycin biosynthesis cluster of Streptomyces cyanogenus (192 aa) fasta scores%3B opt: 201%2C z-score: 245.8%2C E(): 2.3e-06%2C (33.3%25 identity in 159 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and probable helix-turn-helix 31-52 (+5.06 SD). gene gene3859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3833 SCO3834 SCO3834 SCH69.04c SCH69.04c 4215803 4217317 - 3-hydroxyacyl-CoA dehydrogenase converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation gene gene3860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3834 SCO3835 SCO3835 SCH69.05 SCH69.05 4217476 4219167 + dehydrogenase SCH69.05%2C possible dehydrogenase%2C len: 563aa%3B similar to many eg. SW:PUTA_ECOLI proline dehydrogenase (1320 aa) fasta scores%3B opt: 256%2C z-score: 285.1%2C E(): 1.5e-08%2C (27.1%25 identity in 376 aa overlap). gene gene3861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3835 SCO3836 SCO3836 SCH69.06c SCH69.06c 4219178 4219963 - rRNA methylase SCH69.06c%2C possible rRNA methylase%2C len: 261aa%3B similar to many eg. TR:O84408 (EMBL:AE001313) rRNA methylase (269 aa) fasta scores%3B opt: 197 z-score: 225.0 E(): 3.3e-05 (26.8%25 identity in 235 aa overlap). Contains Pfam match to entry PF00588 SpoU_methylase%2C SpoU rRNA Methylase family. gene gene3862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3836 SCO3837 SCO3837 SCH69.07c SCH69.07c 4219960 4221270 - hypothetical protein SCH69.07c%2C membrane protein%2C len: 436 aa. Contains possible hydrophobic membrane spanning regions gene gene3863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3837 SCO3838 SCO3838 SCH69.08c SCH69.08c 4221267 4222505 - hypothetical protein SCH69.08c%2C membrane protein%2C len: 412 aa%3B contains 7 x QG repeat 65-78aa. Contains possible hydrophobic membrane spanning region gene gene3864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3838 SCO3839 SCO3839 SCH69.09c SCH69.09c 4222523 4222852 - hypothetical protein SCH69.09c%2C unknown%2C len: 109aa%3B similar to SW:GLPE_ECOLI protein of unknown function from the sn-glycerol 3-phosphate regulon of Escherichia coli (108 aa) fasta scores%3B opt: 154%2C z-score: 209.1%2C E(): 0.00026%2C (33.3%25 identity in 78 aa overlap). gene gene3865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3839 SCO3840 SCO3840 SCH69.10c SCH69.10c 4222903 4223718 - hypothetical protein SCH69.10c%2C unknown%2C len: 271aa%3B similar to TR:P74322 (EMBL:D90914) from Synechocystis sp. PCC6803 (228 aa) fasta scores%3B opt: 238%2C z-score: 277.0%2C E(): 4.2e-08%2C (26.6%25 identity in 259 aa overlap). Contains possible coiled-coil at 30-40aa. gene gene3866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3840 SCO3841 SCO3841 SCH69.11c SCH69.11c 4223858 4225387 - hypothetical protein SCH69.11c%2C unknown%2C len: 509aa%3B similar to TR:O86499 (EMBL:AL031232) hypothetical protein from Streptomyces coelicolor (469 aa) fasta scores%3B opt: 648%2C z-score: 691.5%2C E(): 3.5e-31%2C (41.6%25 identity in 471 aa overlap) gene gene3867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3841 SCO3842 SCO3842 SCH69.12 SCH69.12 4225790 4226674 + dioxygenase SCH69.12%2C possible dioxygenase%2C len: 294aa%3B similar to many catechol dioxygenases eg. TR:O31247 (EMBL:AJ000187) catechol 1.2-dioxygenase from Arthrobacter sp. mA3 (282 aa) fasta scores%3B opt: 181%2C z-score: 193.2%2C E(): 0.002%2C (32.8%25 identity in 177 aa overlap). Contains Pfam match to entry PF00775 Dioxygenase%2C Dioxygenase. Also contains possible membrane spanning hydrophobic region gene gene3868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3842 SCO3843 SCO3843 SCH69.13 SCH69.13 4227374 4228246 + hypothetical protein SCH69.13%2C unknown%2C len: 290 aa%3B similar to the N-terminal region of TR:P71590 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (527 aa) fasta scores%3B opt: 268%2C z-score: 221.4%2C E(): 5.3e-05%2C (28.1%25 identity in 217 aa overlap). gene gene3870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3843 SCO3844 SCO3844 SCH69.14 SCH69.14 4228257 4228775 + hypothetical protein SCH69.14%2C hypothetical protein%2C len: 172 aa%3B similar to TR:P71589 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (155 aa) fasta scores%3B opt: 389%2C z-score: 442.8%2C E(): 2.5e-17%2C (46.2%25 identity in 171 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene3871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3844 SCO3845 SCO3845 SCH69.15 SCH69.15 4228917 4230464 + protein phosphatase SCH69.15%2C possible protein phosphatase%2C len: 515aa%3B similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores%3B opt: 989%2C z-score: 916.0%2C E(): 0%2C (42.9%25 identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores%3B opt: 966%2C z-score: 895.0%2C E(): 0%2C (40.0%25 identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C%2C Protein phosphatase 2C. could have a role in signalling. gene gene3872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3845 SCO3846 SCO3846 SCH69.16 SCH69.16 4230492 4231931 + FtsW/RodA/SpoVE family cell cycle protein SCH69.16%2C probable FtsW/RodA/SpoVE family cell cycle protein%2C len: 479aa%3B similar to many egs. SW:FTSW_MYCTU probable cell division protein FtsW from Mycobacterium tuberculosis (469 aa) fasta scores%3B opt: 1367%2C z-score: 1568.6%2C E(): 0%2C (48.8%25 identity in 451 aa overlap) and SW:SP5E_BACSU stage V sporulation protein E from Bacillus subtilis (366 aa) fasta scores%3B opt: 496%2C z-score: 572.9%2C E(): 1.4e-24%2C (31.7%25 identity in 391 aa overlap). Also similar to SC6G9.31 from Streptomyces coelicolor (446 aa) fasta scores%3B opt: 1132%2C z-score: 1182.0%2C E(): 0%2C (58.6%25 identity in 444 aa overlap). Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE%2C Cell cycle protein. Also contains possible membrane spanning hydrophobic regions. gene gene3873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3846 SCO3847 SCO3847 SCH69.17 SCH69.17 4231928 4233400 + penicillin-binding protein SCH69.17%2C probable penicillin-binding protein%2C len: 490 aa%3B similar to many e.g. TR:P71586 (EMBL:Z80233) penicillin-binding protein from Mycobacterium tuberculosis (491 aa) fasta scores%3B opt: 112%2C1 z-score: 1262.1%2C E(): 0%2C (39.3%25 identity in 499 aa overlap) and SW:PBPC_BACSU penicillin-binding protein 3 from Bacillus subtilis (668 aa) fasta scores%3B opt: 447%2C z-score: 502.5%2C E(): 1.2e-20%2C (29.0%25 identity in 386 aa overlap). Also similar to SC6G9.32 from Streptomyces coelicolor (485 aa) fasta scores%3B opt: 1493%2C z-score: 1531.4%2C E(): 0%2C (49.4%25 identity in 488 aa overlap). Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain. Also contains possible N-terminal signal sequence. gene gene3874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3847 SCO3848 SCO3848 SCH69.18 SCH69.18 4233591 4235612 + Ser/Thr protein kinase SCH69.18%2C possible Ser/Thr protein kinase%2C len: 673 aa%3B similar to many e.g. TR:P71584 (EMBL:Z80233) Ser/Thr protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores%3B opt: 1185%2C z-score: 1028.0%2C E(): 0%2C (42.0%25 identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) Ser/Thr protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores%3B opt: 598%2C z-score: 522.8%2C E(): 8.6e-22%2C (33.9%25 identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores%3B opt: 1104%2C z-score: 1039.5%2C E(): 0%2C (50.0%25 identity in 392 aa overlap). Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain. Also contains possible membrane spanning hydrophobic region. gene gene3875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3848 SCO3849 SCO3849 SCH69.19c SCH69.19c 4235691 4236452 - hypothetical protein SCH69.19c%2C possible integral membrane protein%2C len: 253 aa%3B contains possible membrane spanning hydrophobic region. Similar to neighbouring gene SCH69.20c fasta scores%3B opt: 651%2C z-score: 689.2%2C E(): 2.8e-33%2C (45.9%25 identity in 218 aa overlap) gene gene3876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3849 SCO3850 SCO3850 SCH69.20c SCH69.20c 4236466 4237524 - hypothetical protein SCH69.20c%2C possible integral membrane protein%2C len: 352 aa%3B contains possible membrane spanning hydrophobic region. Similar to neighbouring gene SCH69.19c fasta scores%3B opt: 651%2C z-score: 547.1%2C E(): 2.3e-25%2C (45.9%25 identity in 218 aa overlap) gene gene3877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3850 SCO3851 SCO3851 SCH69.21c SCH69.21c 4237521 4238159 - para-aminobenzoate synthase component II aminodeoxychorismate synthase subunit PabA%3B with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis%3B PabA provides the glutamine amidotransferase activity gene gene3878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3851 SCO3852 SCO3852 SCH69.22c SCH69.22c 4238156 4238365 - hypothetical protein SCH69.22c%2C membrane protein%2C len: 69 aa. Contains possible hydrophobic membrane spanning region gene gene3879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3852 SCO3853 SCO3853 SCH69.23c SCH69.23c 4238399 4239112 - hypothetical protein SCH69.23c%2C possible membrane protein%2C len: 237 aa%3B similar to TR:P71582 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (262 aa) fasta scores%3B opt: 506%2C z-score: 588.6%2C E(): 1.9e-25%2C (39.8%25 identity in 236 aa overlap). Contains possible membrane spanning hydrophobic region at the N-terminus. gene gene3880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3853 SCO3854 SCO3854 SCH69.24 SCH69.24 4239330 4239584 + septation inhibitor protein integral membrane protein involved in inhibition of the Z-ring formation gene gene3881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3854 SCO3855 SCO3855 SCH69.25c SCH69.25c 4239852 4240745 - hypothetical protein SCH69.25c%2C possible membrane protein%2C len: 297aa%3B similar to TR:O53632 (EMBL:AL021926) transmembrane protein from Mycobacterium tuberculosis (249 aa) fasta scores%3B opt: 552%2C z-score: 598.7%2C E(): 5.1e-26%2C (45.4%25 identity in 251 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene3882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3855 SCO3856 SCO3856 SCH69.26c SCH69.26c 4240850 4241383 - peptidyl-prolyl cis-trans isomerase SCH69.26c%2C probable peptidyl-prolyl cis-trans isomerase%2C len: 177aa%3B similar to many egs. TR:P77949 (EMBL:U64692) peptidyl-prolyl cis-trans isomerase from Streptomyces chrysomallus (175 aa) fasta scores%3B opt: 950%2C z-score: 1136.4%2C E(): 0%2C (78.3%25 identity in 175 aa overlap) and TR:O54168 (EMBL:AL021411) peptidyl-prolyl isomerase from Streptomyces coelicolor (157 aa) fasta scores%3B opt: 400%2C z-score: 486.8%2C E(): 8.8e-20%2C (50.0%25 identity in 124 aa overlap). Contains Pfam match to entry PF00160 pro_isomerase%2C Peptidyl-prolyl cis-trans isomerase. gene gene3883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3856 SCO3857 SCO3857 SCH69.27 SCH69.27 4241704 4242402 + regulatory protein SCH69.27%2C possible regulatory protein%2C len: 232aa%3B similar to SW:NHSR_STRAS proposed regulator of the nosiheptide-resistance genes from Streptomyces actuosus (233 aa) fasta scores%3B opt: 1231%2C z-score: 1330.5%2C E(): 0%2C (83.2%25 identity in 226 aa overlap). gene gene3884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3857 SCO3858 SCO3858 SCH69.28c SCH69.28c 4242512 4243288 - UDP pyrophosphate synthase catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate gene gene3885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3858 SCO3859 SCO3859 SCH69.29 SCH69.29 4243938 4244486 + DNA-binding protein SCH69.29%2C possible DNA-binding protein%2C len: 182 aa%3B highly similar to TR:CAA09629 (EMBL:AJ011500) hypothetical protein from granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22 (182 aa) fasta scores%3B opt: 1045%2C z-score: 1158.8%2C E(): 0%2C (90.1%25 identity in 182 aa overlap). Contains probable helix-turn-helix 38-59aa (+3.20 SD). gene gene3887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3859 SCO3860 SCO3860 SCH69.30 SCH69.30 4244573 4246303 + Ser/Thr protein kinase SCH69.30%2C possible Ser/Thr protein kinase%2C len: 576 aa%3B similar to many e.g. TR:CAA09628 (EMBL:AJ011500) Ser/Thr protein kinase from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22 (433 aa) fasta scores%3B opt: 1791%2C z-score: 976.0%2C E(): 0%2C (65.2%25 identity in 428 aa overlap) and SW:PKAA_STRCO PkaA%2C Ser/Thr protein kinase (543 aa) fasta scores%3B opt: 576%2C z-score: 329.1%2C E(): 5.2e-11%2C (29.6%25 identity in 564 aa overlap). Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain. Contains possible hydrophobic membrane spanning region gene gene3888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3860 SCO3861 SCO3861 SCH69.31c SCH69.31c 4246345 4247670 - hypothetical protein SCH69.31c%2C membrane protein%2C len: 441 aa. Contains possible hydrophobic membrane spanning regions gene gene3889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3861 SCO3862 SCO3862 SCH69.32c SCH69.32c 4247800 4248081 - hypothetical protein SCH69.32c%2C membrane protein%2C len: 93 aa. Contains possible hydrophobic membrane spanning region gene gene3890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3862 SCO3863 SCO3863 SCH69.33 SCH69.33 4248267 4248656 + hypothetical protein SCH69.33%2C hypothetical protein%2C len: 129 aa%3B similar to TR:CAA09663 (EMBL:AJ011500) hypothetical protein from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22 (124 aa) fasta scores%3B opt: 259%2C z-score: 293.5%2C E(): 5.1e-09%2C (41.5%25 identity in 118 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene3891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3863 SCO3864 SCO3864 SCH18.01 SCH18.01 4248804 4249592 + transcriptional regulator SCH18.01%2C probable transcriptional regulator (fragment)%2C len: >70 aa%3B similar to TR:Q9X8D7 (EMBL:AL049573) Streptomyces coelicolor GntR-family transcriptional regulator SCE39.14c%2C 243 aa%3B fasta scores: opt: 142 z-score: 189.8 E(): 0.0042%3B 36.8%25 identity in 57 aa overlap. Overlaps with Streptomyces coelicolor transcriptional regulator (fragment) SCH69.34%2C 225 aa~SCH69.34%2C probable transcriptional regulator%2C len: >225aa%3B similar to many egs. TR:Q07191 (EMBL:Z19589) KorSA regulatory protein from the pSAM2 plasmid of Streptomyces ambofaciens (259 aa) fasta scores%3B opt: 224%2C z-score: 275.8%2C E(): 4.9e-08%2C (34.3%25 identity in 233 aa overlap) and SW:HUTC_KLEAE repressor for the histidine utilization genes of Klebsiella aerogenes (241 aa) fasta scores%3B opt: 180%2C z-score: 223.7%2C E(): 3.9e-05%2C (30.4%25 identity in 214 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and probable helix-turn-helix 29-50aa (+3.13 SD). gene gene3892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3864 SCO3865 SCO3865 SCH18.02 SCH18.02 4249601 4250383 + hypothetical protein SCH18.02%2C hypothetical protein%2C len: 260 aa%3B similar to TR:CAB72374 (EMBL:AL138977) Streptomyces coelicolor hypothetical 27.3 kD protein SC7F9.21c%2C 247 aa%3B fasta scores: opt: 296 z-score: 343.9 E(): 1.1e-11%3B 32.9%25 identity in 234 aa overlap. Contains and match to Prosite entry gene gene3893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3865 SCO3866 SCO3866 SCH18.03c SCH18.03c 4250514 4251389 - hypothetical protein SCH18.03c%2C hypothetical protein%2C len: 291 aa%3B similar to TR:P74357 (EMBL:D90914) Synechocystis sp. hypothetical 43.7 kD protein%2C 368 aa%3B fasta scores: opt: 243 z-score: 281.6 E(): 3.3e-08%3B 29.1%25 identity in 206 aa overlap gene gene3894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3866 SCO3867 SCO3867 SCH18.04c SCH18.04c 4251449 4251661 - ferredoxin SCH18.04c%2C soyB1%2C probable ferredoxin%2C len: 70 aa%3B similar to SW:FERS_STRGR (EMBL:X63601) Streptomyces griseus ferredoxin Soy%2C SoyB%2C 65 aa%3B fasta scores: opt: 169 z-score: 239.4 E(): 7.3e-06%3B 44.4%25 identity in 63 aa ovelap gene gene3895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3867 SCO3868 SCO3868 SCH18.05 SCH18.05 4251867 4252493 + hypothetical protein SCH18.05%2C unknown%2C len: 208 aa gene gene3896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3868 SCO3869 SCO3869 SCH18.06 SCH18.06 4252857 4257887 + WD-40 repeat-containing protein SCH18.06%2C probable WD-40 repeat protein%2C len: 1676 aa%3B C-terminal domain identical to previously sequenced TR:Q9ZEM4 (EMBL:AJ131817) Streptomyces coelicolor WD-40 repeat protein WdpA%2C 1049 aa%3B fasta scores: opt: 7025 z-score: 5917.8 E(): 0%3B 99.8%25 identity in 1049 aa overlap. Contains 13x Pfam matches to entry PF00400 WD40%2C WD domain%2C G-beta repeat%2C 9x matches to Prosite entry PS00678 Trp-Asp (WD) repeats signature and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3869 SCO3870 SCO3870 SCH18.07c SCH18.07c 4258228 4258428 - hypothetical protein SCH18.07c%2C possible integral membrane protein%2C len: 66 aa. Contains possible hydrophobic membrane spanning regions gene gene3898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3870 SCO3871 SCO3871 SCH18.08 SCH18.08 4258993 4259403 + decarboxylase SCH18.08%2C possible decarboxylase%2C len: 136 aa%3B similar to TR:O26336 (EMBL:AE000810) Methanobacterium thermoautotrophicum gamma-carboxymuconolactone decarboxylase Mth234%2C 125 aa%3B fasta scores: opt: 231 z-score: 310.2 E(): 8.3e-10%3B 38.3%25 identity in 107 aa overlap gene gene3899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3871 SCO3872 SCO3872 SCH18.09c SCH18.09c 4259979 4260536 - hypothetical protein SCH18.09c%2C possible integral membrane protein%2C len: 185 aa%3B similar to TR:P71575 (EMBL:Z80233) Mycobacterium tuberculosis hypothetical 31.3 kD protein CY10H4.05%2C 304 aa%3B fasta scores: opt: 315 z-score: 339.9 E(): 1.8e-11%3B 32.8%25 identity in 195 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene3901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3872 SCO3873 SCO3873 gyrA gyrA 4260741 4263314 - DNA gyrase subunit A negatively supercoils closed circular double-stranded DNA gene gene3902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3873 SCO3874 SCO3874 gyrB gyrB 4263378 4265438 - DNA gyrase subunit B negatively supercoils closed circular double-stranded DNA gene gene3903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3874 SCO3875 SCO3875 SCH18.12c SCH18.12c 4265873 4266445 - hypothetical protein SCH18.12c%2C hypothetical protein%2C len: 190 aa%3B identical to previously sequenced SW:YREG_STRCO (EMBL:L27063%3B) Streptomyces coelicolor hypothetical 19.8 kD protein in RedF-GyrB intergenic region%2C 190 aa. Similar to many eg. TR:P71573 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (187 aa) fasta scores%3B opt: 404%2C Z-score: 424.8%2C E(): 5e-16%2C 40.741%25 identity (44.767%25 ungapped) in 189 aa overlap. gene gene3904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3875 SCO3876 SCO3876 recF recF 4266442 4267563 - recombination protein F Required for DNA replication%3B binds preferentially to single-stranded%2C linear DNA gene gene3905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3876 SCO3877 SCO3877 SCH18.14c SCH18.14c 4267594 4268469 - 6-phosphogluconate dehydrogenase similar to full-length Gnd%2C these proteins seems to have a truncated C-terminal 6PGD domainin%3B in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate gene gene3906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3877 SCO3878 SCO3878 dnaN dnaN 4268713 4269843 - DNA polymerase III subunit beta binds the polymerase to DNA and acts as a sliding clamp gene gene3907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3878 SCO3879 SCO3879 dnaA dnaA 4270778 4272748 - chromosomal replication initiation protein binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication%3B can also affect transcription of multiple genes including itself. gene gene3908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3879 SCO3880 SCO3880 rpmH rpmH 4273127 4273264 + 50S ribosomal protein L34 in Escherichia coli transcription of this gene is enhanced by polyamines gene gene3909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3880 SCO3881 SCO3881 rnpA rnpA 4273286 4273657 + ribonuclease P component StH24.03%2C rnpA%2C probable ribonuclease P component%2C len: 123 aa%3B previously sequenced as SW:RNPA_STRCO (EMBL:M82836)%2C RnpA. Similar to SW:RNPA_STRBI (EMBL:M83112)%2C rnpA%2C Streptomyces bikiniensis ribonuclease P protein component (123 aa)%2C fasta scores%3B opt: 704 z-score: 879.0 E(): 0%2C 88.6%25 identity in 123 aa overlap .Contains Pfam match to entry PF00825 Ribonuclease_P%2C Ribonuclease P%2C score 179.50%2C E-value 5.3e-50 and PS00648 Bacterial Ribonuclease P protein component signature gene gene3910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3881 SCO3882 SCO3882 StH24.04 StH24.04 4273654 4274028 + hypothetical protein StH24.04%2C conserved hypothetical protein%2C len: 124 aa%3B previously sequenced as TR:O54625 (EMBL:Y16311) Streptomyces coelicolor hypothetical protein (124 aa). Similar to many bacterial proteins from RnpA region e.g. YIDD_PROMI (EMBL:M58352) Proteus mirabilis hypothetical protein (86 aa)%2C fasta scores%3B opt: 278 z-score: 336.6 E(): 2e-11%2C 57.4%25 identity in 68 aa overlap. Also similar to haemolysins e.g. TR:Q44066 (EMBL:L36462)%2C HylA%2C Aeromonas hydrophila alpha-hemolysin (85 aa) (54.5%25 identity in 66 aa overlap) gene gene3911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3882 SCO3883 SCO3883 StH24.05 StH24.05 4274032 4275327 + inner membrane protein translocase component YidC functions to insert inner membrane proteins into the IM in Escherichia coli%3B interacts with transmembrane segments%3B functions in both Sec-dependent and -independent membrane insertion%3B similar to Oxa1p in mitochondria gene gene3912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3883 SCO3884 SCO3884 SCH24.06 SCH24.06 4275343 4275855 + hypothetical protein SCH24.06%2C conserved hypothetical protein%2C len: 170 aa%3B previously sequenced as TR:O54595 (EMBL:Y16311) Streptomyces coelicolor jag-like protein (170 aa). Similar to SW:JAG_BACSU (EMBL:Z14225)%2C jag%2C Bacillus subtilis SpoIIIJ associated protein (208 aa)%2C fasta scores%3B opt: 231 z-score: 268.4 E(): 1.1e-07%2C 31.7%25 identity in 139 aa overlap%2C and other jag homologs e.g. TR:O53598 (EMBL:AL021426) Mycobacterium tuberculosis hypothetical protein (187 aa) (62.7%25 identity in 169 aa overlap) gene gene3913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3884 SCO3885 SCO3885 gidB gidB 4275980 4276699 + 16S rRNA methyltransferase GidB glucose-inhibited division protein B%3B SAM-dependent methyltransferase%3B methylates the N7 position of guanosine in position 527 of 16S rRNA gene gene3914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3885 SCO3886 SCO3886 StH24.08 StH24.08 4277251 4278078 + partitioning or sporulation protein StH24.08%2C possible partitioning or sporulation protein%2C len: 275 aa%3B previously sequenced as TR:O07328 (EMBL:Y16311) Streptomyces coelicolor hypothetical protein (255 aa)%2C but with a different stop codon position. Similar to many e.g. SW:SOJ_BACSU (EMBL:D26185)%2C SOJ%2C Bacillus subtilis sporulation protein (253 aa)%2C fasta scores%3B opt: 899 z-score: 1077.0 E(): 0%2C 56.6%25 identity in 251 aa overlap%2C TR:O05189 (EMBL:U87804)%2C parA%2C Caulobacter crescentus chromosome partitioning protein (266 aa) (49.2%25 identity in 248 aa overlap) and TR:O53596 (EMBL:AL021426)%2C parB%2C Mycobacterium tuberculosis hypothetical protein (347 aa) (64.3%25 identity in 249 aa overlap). Contains Pfam match to entry PF00991 ParA%2C ParA family ATPase%2C score 123.30%2C E-value 4.4e-33. Contains probable coiled-coil from 86 to 114 (29 residues) (Max score: 1.424%2C probability 0.80) gene gene3915 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3886 SCO3887 SCO3887 StH24.09 StH24.09 4278195 4279181 + partitioning or sporulation protein StH24.09%2C possible partitioning or sporulation protein%2C len: 328 aa%3B previously sequenced as TR:O07327 (EMBL:Y16311)%2C but with different start codon. Similar to many e.g. SW:SP0J_BACSU (EMBL:D26185)%2C spo0J%2C Bacillus subtilis stage 0 sporulation protein (282 aa)%2C fasta scores%3B opt: 686 z-score: 757.0 E(): 0%2C 42.7%25 identity in 262 aa overlap%2C TR:O05190 (EMBL:U87804)%2C parB%2C Caulobacter crescentus chromosome partitioning protein (293 aa) (37.1%25 identity in 264 aa overlap) and TR:O53595 (EMBL:AL021426)%2C parA%2C Mycobacterium tuberculosis hypothetical protein (344 aa) (51.4%25 identity in 360 aa overlap). Contains probable helix-turn-helix motif at aa 160-181 (Score 1587%2C +4.59 SD) gene gene3916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3887 SCO3888 SCO3888 StH24.10 StH24.10 4279519 4280136 + hypothetical protein StH24.10%2C conserved hypothetical protein%2C len: 205 aa%3B previously sequenced as TR:O07326 (EMBL:AF031590)%2C unknown function%2C similar to TR:O53594 (EMBL:AL021426) Mycobacterium tuberculosis hypothetical protein (244 aa)%2C fasta scores%3B opt: 392 z-score: 473.7 E(): 4.5e-19%2C 40.2%25 identity in 234 aa overlap and TR:Q50200 (EMBL:L39923) hypothetical protein (259 aa) (39.6%25 identity in 240 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family%2C score 17.80%2C E-value 0.018 gene gene3917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3888 SCO3889 SCO3889 SCH24.11c SCH24.11c 4280212 4280544 - thioredoxin SCH24.11c%2C trxA%2C thioredoxin%2C len: 110 aa%3B previously sequenced (EMBL:AJ007313)%2C TrxA. Contains Pfam match to entry PF00085 thiored%2C Thioredoxin%2C score 140.90%2C E-value 3.6e-41 and PS00194 Thioredoxin family active site gene gene3918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3889 SCO3890 SCO3890 SCH24.12c SCH24.12c 4280583 4281551 - thioredoxin reductase SCH24.12c%2C trxB%2C thioredoxin reductase (NADPH)%2C len: 322 aa%3B previously sequenced as SW:TRXB_STRCO (EMBL:AJ007313)%2C TrxB. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site gene gene3919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3890 SCO3891 SCO3891 SCH24.13c SCH24.13c 4281711 4282559 - hypothetical protein SCH24.13c%2C possible membrane protein%2C len: 282 aa%3B unknown function%2C previously sequenced as TR:O86857 (EMBL:AJ007313)%2C ORF2. Contains hydrophobic%2C possible membrane-spanning region gene gene3920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3891 SCO3892 SCO3892 SCH24.14c SCH24.14c 4282577 4283287 - RNA polymerase sigma factor SigM Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase gene gene3921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3892 SCO3893 SCO3893 SCH24.15c SCH24.15c 4283316 4285007 - hypothetical protein SCH24.15c%2C hypothetical protein%2C len: 563 aa%3B unknown function%2C previously partially sequenced as TR:O86855 (EMBL:AJ007313) Streptomyces coelicolor hypothetical protein (281 aa). Weakly similar to TR:Q53839 (EMBL:U19250) Streptomyces coelicolor protein kinase-like protein (565 aa)%2C fasta scores%3B opt: 205 z-score: 204.5 E(): 0.00045%2C 25.1%25 identity in 263 aa overlap and to C-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa) (26.9%25 identity in 557 aa overlap) gene gene3922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3893 SCO3894 SCO3894 SCH24.16c SCH24.16c 4285147 4287582 - transmembrane protein SCH24.16c%2C probable transmembrane protein%2C len: 811 aa%3B unknown function%2C similar to hypothetical proteins e.g. the N-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa)%2C fasta scores%3B opt: 573 z-score: 440.2 E(): 3.4e-17%2C 31.1%25 identity in 573 aa overlap and TR:Q50198 (EMBL:L39923) Mycobacterium leprae hypothetical protein (379 aa) (31.7%25 identity in 398 aa overlap). Also weakly similar to SW:MVIN_SALTY (EMBL:Z26133) Salmonella typhimurium 'mvin' (524 aa) (26.8%25 identity in 456 aa overlap). The N-terminal third is hydrophilic%2C while the remainder contains hydrophobic%2C probable membrane-spanning regions gene gene3923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3894 SCO3895 SCO3895 SCH24.17c SCH24.17c 4287627 4289990 - hypothetical protein SCH24.17c%2C membrane protein%2C len: 787 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains possible hydrophobic membrane spanning regions gene gene3924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3895 SCO3896 SCO3896 SCH24.18 SCH24.18 4290216 4291667 + RNA nucleotidyltransferase SCH24.18%2C probable RNA nucleotidyltransferase%2C len: 483 aa%3B similar to tRNA nucleotidyltransferases e.g. SW:CCA_ECOLI (EMBL:M12788)%2C cca%2C Escherichia coli tRNA nucleotidyltransferase (412 aa)%2C fasta scores%3B opt: 413 z-score: 480.7 E(): 1.8e-19%2C 33.8%25 identity in 334 aa overlap. Also similar to mRNA poly(A) polymerases e.g. SW:PCNB_ECOLI (EMBL:S48039)%2C pcnB%2C Escherichia coli poly(A) polymerase (472 aa) (32.0%25 identity in 256 aa overlap). Contains probable coiled-coil from 392 to 425 (34 residues) (Max score: 1.525%2C probability 0.97) gene gene3925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3896 SCO3897 SCO3897 SCH24.19c SCH24.19c 4291764 4292357 - hypothetical protein SCH24.19c%2C hypothetical protein%2C len: 197 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains proline/glutamine-rich region from residues 24-87 approx. and TTA (leucine) codon%2C possible target for bldA regulation%2C near N-terminus gene gene3926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3897 SCO3898 SCO3898 SCH24.20c SCH24.20c 4292389 4293666 - hypothetical protein SCH24.20c%2C probable membrane protein%2C len: 425 aa%3B unknown function%2C similar to many membrane proteins e.g. SW:YO37_MYCTU (EMBL:Z80233) Mycobacterium tuberculosis hypothetical protein (441 aa)%2C fasta scores%3B opt: 725 z-score: 832.9 E(): 0%2C 36.5%25 identity in 408 aa overlap and to resistance determinants e.g. TR:O3113 (EMBL:AF030344)%2C tetV%2C Mycobacterium smegmatis tetracycline-resistance determinant (419 aa) (24.5%25 identity in 416 aa overlap). Similar to TR:O69824 (EMBL:AL023496) S.coelicolor possible integral membrane protein (630 aa) (27.0%25 identity in 429 aa overlap) and TR:O69821 (EMBL:AL023496) S.coelicolor probable transmembrane protein (431 aa) (23.1%25 identity in 428 aa overlap). Contains several hydrophobic%2C probable membrane-spanning regions gene gene3927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3898 SCO3899 SCO3899 SCH24.21c SCH24.21c 4293746 4294828 - hypothetical protein SCH24.21c%2C conserved hypothetical protein%2C len: 360 aa%3B unknown function%2C similar to e.g. TR:P71703 (EMBL:Z80775) Mycobacterium tuberculosis hypothetical protein (367 aa)%2C fasta scores%3B opt: 1790 z-score: 2136.2 E(): 0%2C 78.5%25 identity in 353 aa overlap. C-terminal half shows weak similarity with a region of SW:INO1_CANAL (EMBL:L22737)%2C Ino1%2C Candida albicans myo-inositol-1-phosphate synthase (520 aa) (26.3%25 identity in 251 aa overlap) and with TR:O69948 (EMBL:AL023862) S.coelicolor probable hypothetical protein (417 aa) (25.2%25 identity in 226 aa overlap) gene gene3928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3899 SCO3900 SCO3900 SCH24.22c SCH24.22c 4294873 4295550 - hypothetical protein SCH24.22c%2C conserved hypothetical protein%2C len: 225 aa%3B unknown function%2C similar to e.g. TR:P71704 (EMBL:Z80775) Mycobacterium tuberculosis hypothetical protein (180 aa)%2C fasta scores%3B opt: 583 z-score: 671.1 E(): 4.5e-30%2C 51.4%25 identity in 177 aa overlap. Contains probable coiled-coil from 121 to 165 (45 residues) (Max score: 1.819%2C probability 1.00) gene gene3929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3900 SCO3901 SCO3901 SCH24.23 SCH24.23 4296215 4298602 + penicillin-binding protein SCH24.23%2C probable penicillin-binding protein%2C len: 795 aa%3B similar to many e.g. SW:PBPF_BACSU (EMBL:Y14083)%2C PbpF%2C Bacillus subtilis penicillin-binding protein 1A (714 aa)%2C fasta scores%3B opt: 439 z-score: 369.7 E(): 2.8e-13%2C 31.2%25 identity in 683 aa overlap. Contains hydrophobic%2C possible membrane-spanning region at N-terminus. Contains Pfam matches to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain%2C score 49.60%2C E-value 2.8e-11 and entry PF00912 Transglycosyl%2C Transglycosylase%2C score 172.40%2C E-value 7.3e-48. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene3930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3901 SCO3902 SCO3902 SH24.24 SH24.24 4298723 4300231 + hypothetical protein SH24.24%2C probable integral membrane protein%2C len: 502 aa%3B unknown function%2C similar to transmembrane proteins from Mycobacteria e.g. TR:O53127 (EMBL:AL022118) Mycobacterium leprae transmembrane protein (564 aa)%2C fasta scores%3B opt: 520 z-score: 575.6 E(): 9.5e-25%2C 38.4%25 identity in 490 aa overlap. Contains several hydrophobic%2C probable membrane-spanning regions gene gene3931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3902 SCO3903 SCO3903 SCH24.25c SCH24.25c 4300309 4301340 - hypothetical protein SCH24.25c%2C hypothetical protein%2C len: 343 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene3932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3903 SCO3904 SCO3904 SCH24.26c SCH24.26c 4301402 4302523 - hypothetical protein SCH24.26c%2C conserved hypothetical protein%2C len: 373 aa%3B weakly similar to many e.g. SW:FEMA_STAAU (EMBL:M23918)%2C femA%2C Staphylococcus aureus factor essential for expression of methicillin resistance (433 aa)%2C fasta scores%3B opt: 169 z-score: 200.3 E(): 0.00076%2C 21.7%25 identity in 428 aa overlap gene gene3933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3904 SCO3905 SCO3905 SCH24.27c SCH24.27c 4302661 4302966 - hypothetical protein SCH24.27c%2C membrane protein%2C len: 101 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains possible hydrophobic membrane spanning regions gene gene3934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3905 SCO3906 SCO3906 rpsF rpsF 4303242 4303532 + 30S ribosomal protein S6 binds cooperatively with S18 to the S15-16S complex%2C allowing platform assembly to continue with S11 and S21 gene gene3935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3906 SCO3907 SCO3907 SCH24.29 SCH24.29 4303613 4304212 + single-stranded DNA-binding protein binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA gene gene3936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3907 SCO3908 SCO3908 rpsR rpsR 4304258 4304494 + 30S ribosomal protein S18 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%3B helps stabilize the platform of the 30S subunit gene gene3937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3908 SCO3909 SCO3909 rplI rplI 4304513 4304959 + 50S ribosomal protein L9 in Escherichia coli this protein is wrapped around the base of the L1 stalk gene gene3938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3909 SCO3910 SCO3910 SCH24.32c SCH24.32c 4305060 4306406 - hypothetical protein SCH24.32c%2C membrane protein%2C len: 448 aa%3B similar to many e.g. SW:DINF_ECOLI (EMBL:L02362)%2C DinF%2C Escherichia coli DNA-damage-inducible protein (459 aa)%2C fasta scores%3B opt: 571 z-score: 655.4 E(): 3.4e-29%2C 30.0%25 identity in 437 aa overlap. There is an alternative start codon at the third amino acid. Contains possible hydrophobic membrane spanning regions gene gene3939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3910 SCO3911 SCO3911 dnaB dnaB 4306857 4308332 + replicative DNA helicase SCH24.33%2C dnaB%2C probable replicative DNA helicase%2C len: 491 aa%3B similar to many e.g. SW:DNAB_ECOLI (EMBL:K01174)%2C DnaB%2C Escherichia coli replicative DNA helicase (471 aa)%2C fasta scores%3B opt: 1144 z-score: 1233.0 E(): 0%2C 38.6%25 identity in 461 aa overlap. The position of the start codon is suggested with reference to GC frame plot and a potential RBS. Contains Pfam match to entry PF00772 DnaB%2C DnaB-like helicase%2C score 558.50%2C E-value 4.4e-164 and PS00017 ATP/GTP-binding site motif A (P-loop). Contains probable helix-turn-helix motif at aa 392-413 (Score 982%2C +2.53 SD) gene gene3940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3911 SCO3912 SCO3912 SCH24.34 SCH24.34 4308427 4309812 + beta-lactamase SCH24.34%2C possible beta-lactamase%2C len: 461 aa%3B similar to many e.g. TR:P71420 (EMBL:X92508) Klebsiella pneumoniae ES-beta-lactamase precursor (382 aa)%2C fasta scores%3B opt: 234 z-score: 262.3 E(): 2.7e-07%2C 25.7%25 identity in 378 aa overlap. Weakly similar to TR:O88012 (EMBL:AL031107) S.coelicolor hypothetical protein SC5A7.06c (409 aa) (29.3%25 identity in 376 aa overlap) gene gene3941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3912 SCO3913 SCO3913 SCH24.35c SCH24.35c 4309887 4310339 - hypothetical protein SCH24.35c%2C hypothetical protein%2C len: 150 aa%3B similar to TR:Q54244 (EMBL:D29961) Streptomyces griseus phnO-like regulator for C-P lyase (150 aa)%2C fasta scores%3B opt: 797 z-score: 972.8 E(): 0%2C 79.3%25 identity in 150 aa overlap and to SW:PHNO_ECOLI (EMBL:D90227)%2C phnO%2C in Escherichia coli alkylphosphonate utilization operon (144 aa) (32.2%25 identity in 146 aa overlap). Weakly similar to TR:O86792 (EMBL:AL031317) S.coelicolor probable acetyltransferase (177 aa) (32.7%25 identity in 150 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family%2C score 80.70%2C E-value 3.1e-20 gene gene3942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3913 SCO3914 SCO3914 SCH24.36c SCH24.36c 4310386 4310850 - transcriptional regulator SCH24.36c%2C probable transcriptional regulator%2C len: 154 aa%3B weakly similar to SW:PECS_ERWCH (EMBL:X74409) PecS%2C Erwinia chrysanthemi regulator of pectinase%2C cellulase%2C and blue pigment production (166 aa)%2C fasta scores%3B opt: 136 z-score: 183.2 E(): 0.0068%2C 30.5%25 identity in 95 aa overlap. Also similar to other regulatory proteins. Contains Pfam match to entry PF01047 MarR%2C MarR family%2C score 52.20%2C E-value 1.1e-11 gene gene3943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3914 SCO3915 SCO3915 SCH24.37 SCH24.37 4310991 4312205 + transmembrane efflux protein SCH24.37%2C probable transmembrane efflux protein%2C len: 404 aa%3B similar to many e.g. TR:Q56147 (EMBL:U09991)%2C cmlV%2C Streptomyces violaceus chloramphenicol efflux pump (436 aa)%2C fasta scores%3B opt: 1012 z-score: 1048.2 E(): 0%2C 40.5%25 identity in 395 aa overlap. Similar to other efflux proteins from S.coelicolor e.g. SCE94.17c (EMBL:AL049628) possible exporter (531 aa) (26.8%25 identity in 395 aa overlap). Contains several hydrophobic%2C probable membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter%2C score -61.60%2C E-value 0.00088 gene gene3944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3915 SCO3916 SCO3916 SCH24.38 SCH24.38 4312354 4312773 + hypothetical protein SCH24.38%2C conserved hypothetical protein%2C len: 139 aa%3B similar to many e.g. SW:YDHY_CITFR (EMBL:U09771) Citrobacter freundii hypothetical protein (142 aa)%2C fasta scores%3B opt: 257 z-score: 321.3 E(): 1.4e-10%2C 35.4%25 identity in 130 aa overlap gene gene3945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3916 SCO3917 SCO3917 SCH24.39c SCH24.39c 4312891 4313757 - hypothetical protein SCH24.39c%2C hypothetical protein%2C len: 288 aa%3B unknown function%2C similar to TR:O06743 (EMBL:Y09476)%2C yitH%2C Bacillus subtilis hypothetical protein (282 aa)%2C fasta scores%3B opt: 288 z-score: 349.1 E(): 3.9e-12%2C 26.8%25 identity in 231 aa overlap and TR:P73419 (EMBL:D90906) Synechocystis sp. hypothetical protein (285 aa) (21.9%25 identity in 265 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family%2C score 17.40%2C E-value 0.02 gene gene3946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3917 SCO3918 SCO3918 SCH24.40c SCH24.40c 4313836 4314318 - hypothetical protein SCQ11.01c%2C hypothetical protein%2C partial CDS%2C len: >95 aa%3B unknown function%2C previously sequenced as TR:Q53870 (EMBL:U37580)%2C S.coelicolor hypothetical protein ORF5 downstream of phosphotyrosine protein phosphatase (159 aa). Weak similarity to the N-terminus of TR:O69888 (EMBL:AL023797) Streptomyces coelicolor hypothetical protein (172 aa)%2C fasta scores%3B opt: 158 z-score: 206.4 E(): 0.00036%2C 46.2%25 identity in 65 aa overlap. Continues as SCH24.40c in cosmid H24 (EMBL:AL049826)~SCH24.40c%2C hypothetical protein%2C partial CDS%2C len: >96 aa%3B unknown function%2C highly similar to TR:Q53870 (EMBL:U37580) S.coelicolor hypothetical protein ORF5 downstream of phosphotyrosine protein phosphatase (159 aa)%2C fasta scores%3B opt: 615 z-score: 859.5 E(): 0%2C 94.8%25 identity in 96 aa overlap gene gene3947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3918 SCO3919 SCO3919 abaB abaB 4314389 4315294 - LysR family transcriptional regulator SCQ11.02c%2C abaB%2C probable lysR-family transcriptional regulator%2C len: 301 aa%3B previously sequenced as TR:Q53869 (EMBL:U37580) S.coelicolor lysR-like protein (301 aa). Highly similar to SW:ARAB_STRAT (EMBL:X91393)%2C AraB%2C Streptomyces antibioticus transcriptional regulatory protein (301 aa)%2C fasta scores%3B opt: 1581 z-score: 1813.2 E(): 0%2C 80.3%25 identity in 300 aa overlap. Similar to many other transcriptional regulators. Contains probable helix-turn-helix motif at aa 17-38 (Score 1659%2C +4.84 SD). Contains Pfam match to PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and PS00044 Bacterial regulatory proteins%2C lysR family signature gene gene3948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3919 SCO3920 SCO3920 cysA cysA 4315547 4316725 - cystathionine gamma-lyase catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine gene gene3949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3920 SCO3921 SCO3921 ptpA ptpA 4316722 4317216 - low molecular weight protein-tyrosine-phosphatase SCQ11.04c%2C ptpA%2C low molecular weight protein-tyrosine-phosphatase%2C len: 164 aa%3B previously sequenced as SW:PTPA_STRCO (EMBL:U37580)%2C ptpA%2C S.coelicolor low molecular weight protein-tyrosine-phosphatase (164 aa). Contains Pfam match to PF01451 LMWPc%2C Low molecular weight phosphotyrosine protein phosphatase gene gene3950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3921 SCO3922 SCO3922 SCQ11.05c SCQ11.05c 4317222 4317599 - hypothetical protein SCQ11.05c%2C possible membrane protein%2C len: 125 aa%3B previously sequenced as SW:YPT3_STRCO (EMBL:U37580) hypothetical 15.9 kD protein in ptpA 5' region (148 aa)%2C with different start codon. Start codon position is suggested here by GC frameplot analysis. Similar to others from mycobacteria and Bacillus subtilis e.g. TR:O07729 (EMBL:Z97193) Mycobacterium tuberculosis possible membrane protein (134 aa) (42.9%25 identity in 126 aa overlap) gene gene3951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3922 SCO3923 SCO3923 SCQ11.06 SCQ11.06 4317659 4317976 + hypothetical protein SCQ11.06%2C hypothetical protein%2C len: 105 aa%3B previously sequenced as SW:YPT2_STRCO (EMBL:U37580) hypothetical 8.2 kD protein in PtpA 5' region (77 aa)%2C with different start codon. Start codon position is suggested here by GC frameplot analysis. Similar to others e.g. to part of TR:O06336 (EMBL:Z95390) Mycobacterium tuberculosis hypothetical protein (177 aa)%2C fasta scores%3B opt: 145 z-score: 207.2 E(): 0.00033%2C (42.1%25 identity in 57 aa overlap) and to TR:Q59013 (EMBL:U67602) Methanococcus jannaschii hypothetical protein (125 aa) (30.2%25 identity in 63 aa overlap). Weakly similar to SC9B5.02 (EMBL:AL035206) S.coelicolor hypothetical protein (128 aa) (28.9%25 identity in 76 aa overlap) gene gene3952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3923 SCO3924 SCO3924 SCQ11.07 SCQ11.07 4318118 4318330 + hypothetical protein SCQ11.07%2C possible membrane protein%2C len: 70 aa%3B previously sequenced as SW:YPT1_STRCO (EMBL:U37580) hypothetical protein in PtpA 5' region (64 aa)%2C with different stop codon. Probable hydrophobic CDS suggested by GC frameplot and positional base preference. Contains possible hydrophobic membrane spanning regions gene gene3953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3924 SCO3925 SCO3925 SCQ11.08 SCQ11.08 4318648 4319373 + transcriptional regulator SCQ11.08%2C probable transcriptional regulator%2C len: 241 aa%3B similar to many transcriptional regulators e.g. TR:Q43992 (EMBL:L05770)%2C pobR%2C Acinetobacter calcoaceticus ADP1 transcriptional activator regulating expression of p-hydroxybenzoate hydroxylase (PobA) (271 aa)%2C fasta scores%3B opt: 223 z-score: 262.9 E(): 2.6e-07%2C 25.9%25 identity in 239 aa overlap. Also similar to TR:O88025 (EMBL:AL031107) S.coelicolor probable transcriptional regulator (264 aa) (26.4%25 identity in 239 aa overlap). Contains probable helix-turn-helix motif at aa 19-40 (Score 1331%2C +3.72 SD) and possible hydrophobic membrane spanning region gene gene3954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3925 SCO3926 SCO3926 SCQ11.09 SCQ11.09 4319501 4319911 + regulator SCQ11.09%2C ssgA%2C probable regulator%2C len: 136 aa%3B highly similar to TR:P95753 (EMBL:D50051)%2C SsgA%2C Streptomyces griseus protein associated with sporulation and cell division (136 aa)%2C fasta scores%3B opt: 715 z-score: 896.6 E(): 0%2C 77.9%25 identity in 136 aa overlap and similar to others from S.coelicolor e.g. SC5F2A.05c (EMBL:AL049587) possible regulator (138 aa) (35.7%25 identity in 115 aa overlap) and SC5H1.03 (EMBL:AL049863) possible regulator (142 aa) (2.5%25 identity in 114 aa overlap)%2C both annotated by similarity to Streptomyces griseus SsgA. The start codon was selected by similarity to ssgA gene gene3955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3926 SCO3927 SCO3927 SCQ11.10c SCQ11.10c 4319961 4321502 - hypothetical protein SCQ11.10c%2C possible membrane protein%2C len: 513 aa%3B unknown function%2C probable CDS with Pro/Arg-rich N-terminus and 4x degenerate GGGHGA repeats from aa 58-81. Contains hydrophobic%2C possible membrane-spanning regions gene gene3956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3927 SCO3928 SCO3928 SCQ11.11 SCQ11.11 4321756 4323594 + thiamine biosynthesis protein ThiC required for the synthesis of the hydromethylpyrimidine moiety of thiamine gene gene3957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3928 SCO3929 SCO3929 SCQ11.12c SCQ11.12c 4324441 4325793 - hypothetical protein SCQ11.12c%2C hypothetical protein%2C len: 450 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains TTA (leucine) codon%2C possible target for bldA regulation gene gene3958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3929 SCO3930 SCO3930 SCQ11.13 SCQ11.13 4325990 4326556 + hypothetical protein SCQ11.13%2C hypothetical protein%2C len: 188 aa%3B weakly similar to TR:Q53897 (EMBL:X60316) AbaA ORFA%2C in S. coelicolor pleiotropic regulatory locus for antibiotic production of actinorhodin (192 aa)%2C fasta scores%3B opt: 146 z-score: 190.3 E(): 0.0029%2C 37.0%25 identity in 154 aa overlap. It is not known whether ORFA is involved in antibiotic production. Also weakly similar to SCE9.30 (EMBL:AL049841) S.coelicolor possible regulator containing TTA (leucine) codon near the N-terminus (154 aa) (31.3%25 identity in 131 aa overlap). Contains TTA (leucine) codon%2C possible target for bldA regulation gene gene3959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3930 SCO3931 SCO3931 SCQ11.14 SCQ11.14 4326866 4327165 + hypothetical protein SCQ11.14%2C hypothetical protein%2C len: 99 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene3960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3931 SCO3932 SCO3932 SCQ11.15c SCQ11.15c 4327576 4328355 - GntR family transcriptional regulator SCQ11.15c%2C probable gntR-family transcriptional regulator%2C len: 295 aa%3B similar to many e.g. TR:Q07191 (EMBL:Z19589)%2C KorSA%2C Streptomyces ambofaciens plasmid pSAM2 transcriptional repressor (259 aa)%2C fasta scores%3B opt: 292 z-score: 359.5 E(): 1.1e-12%2C 30.4%25 identity in 253 aa overlap. Also similar to CDS from other integrated plasmids in S.coelicolor e.g. SCE39.09c (EMBL:AL049573)%2C korSA%2C regulatory protein (259 aa) (30.8%25 identity in 253 aa overlap). Part of a integrated plasmid similar to pSAM2. Contains probable helix-turn-helix motif at aa 35-56 (Score 1296%2C +3.60 SD). Contains Pfam match to PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and PS00043 Bacterial regulatory proteins%2C gntR family signature gene gene3961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3932 SCO3933 SCO3933 SCQ11.16 SCQ11.16 4328521 4328871 + regulatory protein SCQ11.16%2C possible regulatory protein%2C len: 116 aa%3B similar to TR:Q53733 (EMBL:Z34987)%2C pra%2C Streptomyces ambofaciens plasmid pSAM2 positive regulator of replicase%2C excisionase%2C and integrase genes (116 aa)%2C fasta scores%3B opt: 161 z-score: 220.6 E(): 5.9e-05%2C 35.0%25 identity in 117 aa overlap. Also similar to CDS from other integrated plasmids in S.coelicolor e.g. SCE39.08c (EMBL:AL049573)%2C Pra%2C regulatory protein (181 aa) (32.5%25 identity in 114 aa overlap). Part of a integrated plasmid similar to pSAM2 gene gene3962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3933 SCO3934 SCO3934 SCD78.01 SCD78.01 4328871 4330172 + ftsK/SpoIIIE family protein SCD78.01%2C ftsK /spoIIIE family protein%2C partial CDS within integrated plasmid%2C len: 271 aa%3B similar to many members of the ftsK /spoIIIE family e.g.SPI_STRAZ (EMBL:S58719) sporulation-regulatory protein from Streptomyces azureus plamsid pSA1.1 (303 aa)%2C fasta scores%3B opt: 736 z-score: 1014.5 E(): 0%2C 49.0%25 identity in 247 aa overlap and TRSA_STRAM (EMBL:Z19593) transfer protein traSA from Streptomyces ambofaciens plasmid pSAM2 (306 aa)%2C fasta scores%3B opt: 222 z-score: 676.5 E(): 2e-30%2C 47.8%25 identity in 203 aa overlap. Also similar to SC6A9.34%2C a protein within another integrated plasmid (on Streptomyces coelicolor cosmid St6A9)(E(): 5.4e-24%2C 45.7%25 identity in 247 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop)~SCQ11.17%2C ftsK/spoIIIE family protein%2C partial CDS%2C len: >200 aa%3B similar to many e.g. part of SW:TRSA_STRAM (EMBL:Z19593)%2C traSA%2C Streptomyces ambofaciens plasmid pSAM2 transfer protein (415 aa)%2C fasta scores%3B opt: 175 z-score: 218.8 E(): 7.4e-05%2C 34.5%25 identity in 116 aa overlap. Also similar to parts of CDS from other integrated plasmids in S.coelicolor e.g. SCE39.09c (EMBL:AL049573) korSA%2C regulatory protein (451 aa) (30.8%25 identity in 182 aa overlap) and TR:O86766 (EMBL:AL031035) probable traSA:integrase fusion protein (768 aa) (33.2%25 identity in 187 aa overlap). Contains TTA (leucine) codon%2C possible target for bldA regulation and PS00017 ATP/GTP-binding site motif A (P-loop. This CDS continues into cosmid D78 (EMBL:AL034355) as SCD78.01 gene gene3963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3934 SCO3935 SCO3935 SCD78.02 SCD78.02 4330169 4330366 + hypothetical protein SCD78.02%2C small hydrophobic protein%2C len: 65 aa%3B within integrated plasmid. Contains possible hydrophobic membrane spanning regions gene gene3964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3935 SCO3936 SCO3936 SCD78.03 SCD78.03 4330663 4332021 + plasmid replication initiator protein SCD78.03%2C possible plasmid replication initiator protein within integrated plasmid%2C len: 452 aa%3B similar to REPS_STRAM (EMBL:Z19594) replication initiator protein from Streptomyces ambofaciens plasmid pSAM2 (459 aa)%2C fasta scores%3B opt: 712 z-score: 983.7 E(): 0%2C (43.7%25 identity in 467 aa overlap). Note that there is no possible initiation codon upstream of the start of homology (or close downstream). The CDS given here has an arbitrary start gene gene3965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3936 SCO3937 SCO3937 SCD78.04c SCD78.04c 4332160 4333647 - integrase /recombinase SCD78.04c%2C possible integrase/ recombinase within integrated plasmid%2C len: 495 aa%3B similar to TR:Q37839 (EMBL:D38173) ORF469 protein (possible site-specific recombinase) from Actinophage R4 (469 aa)%2C fasta scores%3B opt: 261 z-score: 320.1 E(): 1.4e-10%2C 29.1%25 identity in 306 aa overlap and TR:O06604 (EMBL:Z95586) MTCY336.18 (Rv1586c) possible integrase from M. tuberculosis integrated phage phiRv1 (469 aa)%2C fasta scores%3B opt: 371 z-score: 270.8 E(): 7.8e-08%2C (26.6%25 identity in 489 aa overlap). Probable coiled-coil from 414 to 451 (38 residues) Max score: 1.608 (probability 0.99) gene gene3966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3937 SCO3938 SCO3938 SCD78.05 SCD78.05 4333799 4333930 + thiamin biosynthesis protein ThiC SCD78.05%2C thiC'%2C probable thiamin biosynthesis protein ThiC%2C partial CDS%2C len: 43 aa%3B simlar to the extreme C-terminus of e.g. THIC_ECOLI thiamin biosynthesis protein ThiC (631 aa)%2C fasta scores%3B opt: 97 z-score: 137.7 E(): 2%2C 46.2%25 identity in 39 aa overlap and THIC_MYCTU (547 aa)%2C fasta scores%3B opt: 143 z-score: 272.4 E(): 6.4e-08%2C 53.1%25 identity in 49 aa overlap. Note that this gene appears to have been interrupted by the integration of the upstream element gene gene3967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3938 SCO3939 SCO3939 SCD78.06 SCD78.06 4334010 4335458 + hypothetical protein SCD78.06%2C unknown%2C len: 482 aa%3B similar to hypothetical proteins in tellurite resistance operon from Serratia marcescens and Alcaligenes sp. e.g. TR:Q52359 EMBL:L38824 terF gene from Serratia marcesens Plasmid R478 (413 aa)%2C fasta scores%3B opt: 377 z-score: 637.8 E(): 2.8e-28%2C 33.4%25 identity in 479 aa overlap. Also simlar in C-terminus to YCBR_BACSU hypothetical 28.0 kd protein in pcp 5'region (243 aa)%2C fasta scores%3B opt: 301 z-score: 372.2 E(): 1.8e-13%2C 36.6%25 identity in 238 aa overlap. Contains Pro-rich region around aa 200 gene gene3968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3939 SCO3940 SCO3940 SCD78.07c SCD78.07c 4335483 4336355 - transmembrane protein SCD78.07c%2C possible transmembrane protein%2C len: 301 aa%3B contains two possible membrane spanning regions gene gene3969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3940 SCO3941 SCO3941 SCD78.08c SCD78.08c 4336537 4337643 - Ser/Thr protein kinase SCD78.08c%2C probable Ser/Thr protein kinase%2C len: 498 aa%2C identical to TR:G3694948 (EMBL:AF090690) previously sequenced Ser/Thr S. coelicolor. Also similar to TR:O69213 (EMBL:AJ224354) serine-threonine phosphatase PrpA from Anabaena sp. strain PCC 7120 (858 aa) fasta scores%3B opt:102%2C z-score: 234.4%2C E(): 9e-06%2C (26.8%25 identity in 231 aa overlap) contains PS00070 aldehyde dehydrogenases cysteine active site. gene gene3970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3941 SCO3942 SCO3942 SCD78.09 SCD78.09 4337841 4338065 + hypothetical protein SCD78.09%2C unknown%2C len: 109 aa gene gene3971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3942 SCO3943 SCO3943 rstP rstP 4338034 4339146 - transcriptional regulator SCD78.10c%2C probable transcriptional regulator%2C len: 370 aa%3B identical to TR:G3644044 (EMBL:AF090833) transcriptional regulator (RstP) from Streptomyces coelicolor. Also similar to members of the lacI family of transcriptional regulators e.g. PURR_ECOLI ((EMBL:J04212)(fasta scores%3B opt: 345%2C z-score: 356.4%2C E(): 1.3e-12%2C 28.2%25 identity in 347 aa overlap) purine nucleotide synthesis repressor from Escherichia coli. Contains PS00356 Bacterial regulatory proteins%2C lacI family signature and Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C score 13.70%2C E-value 2.3e-06 gene gene3972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3943 SCO3944 SCO3944 hisC2 hisC2 4339565 4340644 + aminotransferase SCD78.11%2C hisC2%2C probable histidinol-phophate aminotransferase len: 369 aa%2C similar to eg%2C HIS8_BACSU (EMBL:U83322) histidinol-phophate aminotransferase from Bacillus subtilis (360 aa)%2C fasta scores opt: 633%2C z-score: 785.8%2C E(): 0%2C (34.5%25 identity in 357 aa overlap). Also similar to S. coelicolor hisC%3B HIS8_STRCO (369 aa)%2C fasta scores%3B opt: 567 z-score: 584.5 E(): 2.8e-25%2C 36.5%25 identity in 367 aa overlap. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. Contains Pfam match to entry PF00222 aminotran_2%2C Aminotransferases class-II%2C score 125.50%2C E-value 9.5e-34 gene gene3973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3944 SCO3945 SCO3945 cydA cydA 4340932 4342437 + cytochrome oxidase subunit I SCD78.12%2C cydA%2C cytochrome oxidase subunit I len: 501 aa%3B similar to e.g. APPC_ECOLI (EMBL:S63811) cytochrome BD-II oxidase subunit I from Escherichia coli (485 aa)%2C fasta scores opt: 1099 z-score: 1869.0 E():0 (48.6%25 identity in 510 aa overlap) and CYDA_BACSU (EMBL:D83026) cytochrome D ubiquinol oxidase subunit I from Bacillus subtilis (468 aa)%2C fasta scores opt: 1178 z-score: 1729.6(43.9%25 identity in 472 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene3974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3945 SCO3946 SCO3946 cydB cydB 4342458 4343462 + cytochrome oxidase subunit II SCD78.13%2C cydB%2C cytochrome oxidase subunit II%2C len: 334 aa%3B similar to CYDB_ECOLI (EMBL:J03939) cytochrome D ubiquinol oxidase subunit II from Escherichia coli (379 aa) fasta scores: opt: 674%2C z-score: 1092.0%2C E():0 (37.3%25 identity in 367 aa overlap) and CYDB_BACSU (EMBL:D83026) cytochrome D ubiquinol oxidase subunit II from Bacillus subtilis (338 aa)%2C fasta scores%3B opt: 1041%2C z-score: 1431.1%2C E():0%2C (47.1%25 identity in 329 aa overlap). Contains possible membrane spanning regions gene gene3975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3946 SCO3947 SCO3947 cydCD cydCD 4343538 4347056 + ABC transporter SCD78.14%2C cydCD%2C probable ABC transporter%2C len: 1172 aa%3B N-terminal similarity to CYDD_ECOLI (EMBL:L21749) ABC transporter ATP-binding protein from Escherichia coli (588 aa)%2C fasta scores%3B opt: 736%2C z-score: 950.9%2C E(): 0%2C (39.2%25 identity in525 aa overlap) and CYDC_BACSU (EMBL :D83026) ABC transporter ATP-binding protein from Bacillus subtilis (567 aa)%2C fasta scores%3B opt: 1174%2C z-score:949.4%2C E(): 0 (36.0%25 identity in 566 aa overlap). Also has full length similarity to MDR4_DROME (EMBL:M59076) multidrug resistance protein homolog from Drosophila melanogaster fasta scores%3B opt: 575%2Cz-score: 856.3%2C E():0%2C (27.0%25 identity in 1162 aa overlap). Contains 2 x ATP /GTP-binding motifs (both PS00017)%2C 2 x ABC transporter family signatures (both PS00211). Also contains Pfam match to entry PF00664 ABC transporter transmembrane region and 2 x Pfam matches to entry PF00005 (see misc_features). Contains possible hydrophobic membrane spanning regions gene gene3976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3947 SCO3948 SCO3948 SCD78.15 SCD78.15 4347161 4348843 + two component sensor SCD78.15%2C possible two component sensor%2C len: 560 aa%3B similar to hypothetical proteins from Mycobacterium tuberculosis (TR:O53473 (EMBL:AL021899) membrane protein fasta scores%3B opt: 1257%2C z-score:1182.6%2C E():0%2C (41.7%25 identity in 554 aa overlap) and TR:P95194 (EMBL:Z83867) hypothetical 62.2kD protein%2C fasta scores%3B opt: 1194%2C z-score: 1014.6%2C E(): 0%2C (41.0%25 identity in 558 aa overlap)) and two component sensor protein from Rhodococcus sp.(TR:G3319300 (EMBL:AF064700) fasta scores%3B opt: 968%2C z-score: 881.2%2C E(): 0%2C (36.7%25 identity in 559 aa overlap) gene gene3977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3948 SCO3949 SCO3949 SCD78.16 SCD78.16 4348966 4350015 + peptidase SCD78.16%2C possible peptidase%2C len: 349 aa%3B similar to conserved hypotheticals including YEBA_ECOLI Hypothetical 46.7 kDa protein from Escherichia coli (419 aa)%2C fasta scores%3B opt: 279 z-score: 336.7%2C E(): 1.7e-11%2C (28.4%25 identity in 341 aa overlap). Also similar to (TR:O54308 (EMBL:U50357) zoocin A endopeptidase from Streptococcus zooepidemicus fasta scores%3B opt: 276%2C z-score: 307.3%2C E(): 7.7e-10%2C (37.2%25 identity in 148 aa overlap) and LSTP_STAST lysostaphin precursor from Staphylococcus staphylolyticus fasta score%3B opt: 270%2C z-score: 249.6%2C E(): 1.3e-06%2C (42.7%25 identity in 110 aa overlap). Probable N-terminal signal sequence. Probable coiled-coils from 42 to 97 (56 residues) Max score: 1.643 (probability 1.00) and from 125 to 193 (69 residues) Max score: 1.653 (probability 1.00) gene gene3978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3949 SCO3950 SCO3950 SCD78.17c SCD78.17c 4350063 4350980 - hypothetical protein SCD78.17c%2C conserved hypothetical protein%2C len: 308 aa%3B similar to e.g. TR:O07810 (EMBL:Z97188) from Mycobacterium tuberculosis fasta scores%3B opt: 503%2C z-score: 626.7%2C E(): 1.2e-27%2C (37.9%25 identity in 277 aa overlap) and YIDA_ECOLI (EMBL:L10328) Escherichia coli fasta scores%3B opt: 297%2C z-score: 407.5%2C E(): 1.9e-15%2C (31.6%25 identity in 282 aa overlap). Also similar to SCD78.27c%2C approx 9kb upstream (37.9%25 identity in 285 aa overlap). Contains Pfam match to entry PF00592 DUF3%2C Domain of Unknown Function 3%2C score 99.00%2C E-value 9.5e-26 gene gene3979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3950 SCO3951 SCO3951 SCD78.18c SCD78.18c 4351038 4352000 - hypothetical protein SCD78.18c%2C unknown%2C len: 320 aa%3B similarity to TR:Q54379 (EMBL:X79146) LmbY(295 aa)%2C part of a gene cluster involved in lincomycin biosynthesis /resistance in Streptomyces lincolnensis%2C fasta scores%3B opt: 814%2C z-score: 584.1%2C E(): 2.8e-25%2C (43.8%25 identity in 290 aa overlap). Also similar to TR:Q49598 (EMBL:U31567) F420-dependent N5%2CN10-methylenetetrahydromethanopterin reductase from Methanopyruskandleri fasta scores%3B opt: 191%2C z-score: 333.9%2C E(): 2.5e-11%2C (29.1%25 identity in 247 aa overlap) gene gene3980 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3951 SCO3952 SCO3952 SCD78.19c SCD78.19c 4351997 4352455 - hypothetical protein SCD78.19c%2C unknown%2C len: 152 aa gene gene3981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3952 SCO3953 SCO3953 SCD78.20c SCD78.20c 4352462 4353010 - RNA 2'-phosphotransferase-like protein in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate%3B functions in tRNA splicing%3B the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown gene gene3982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3953 SCO3954 SCO3954 SCD78.21c SCD78.21c 4353121 4354878 - short chain dehydrogenase SCD78.21c%2C oxidoreductase%2C len: 584 aa%3B N-terminal region similar to Y00P_MYCTU (EMBL:Z70283) oxidoreductase from Mycobacterium tuberculosis (650 aa)%2C fasta scores%3B opt: 1457%2C z-score: 840.1%2C E(): 0%2C 41.0%25 identity in 652 aa overlap. Contains PS00061 short chain dehydrogenases /reductases family signature gene gene3983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3954 SCO3955 SCO3955 SCD78.22c SCD78.22c 4354875 4355894 - hypothetical protein SCD78.22c%2C conserved hypothetical protein%2C len: 339 aa%3B similar to TR:Q9HYS2 (EMBL:AE004754) Pseudomonas aeruginosa hypothetical protein PA3323%2C 291 aa%3B fasta scores: opt: 1052 Z-score: 1194.1 E(): 7e-59%3B 57.143%25 identityin 273 aa overlap. Contains TTA Leu codon: possible target for bldA regulation gene gene3984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3955 SCO3956 SCO3956 SCD78.23 SCD78.23 4355990 4356952 + ABC transporter ATP-binding protein SCD78.23%2C ABC transporter ATP-binding protein%2C similar to YHCH_BACSU (EMBL:X96983) hypothetical ABC transporter ATP-binding protein from Bacillus subtilis%2C fasta scores%3B opt: 438%2C z-score: 522.7%2C E(): 7.2e-22%2C (33.6%25 identity in 220 aa overlap) and YHIH_ECOLI (EMBL:U00039) ABC transporter ATP-binding protein from Escherichia coli fasta scores%3B opt: 445%2C z-score: 530.5%2C E(): 2.6e-22%2C (30.7%25 identity in 287 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 183.40%2C E-value 3.8e-51 and PS00017 ATP /GTP-binding site motif A (P-loop). gene gene3985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3956 SCO3957 SCO3957 SCD78.24 SCD78.24 4356969 4357850 + hypothetical protein SCD78.24%2C possible integral membrane protein%2C len: 293 aa%2C possible membrane spanning hydrophobic regions gene gene3986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3957 SCO3958 SCO3958 SCD78.25 SCD78.25 4357847 4358758 + ABC transporter ATP-binding protein SCD78.25%2C ABC transporter ATP-binding protein%2C len: 303 aa%3B similar to TR:Q45404 (EMBL:U09819) SpaFABC transporter ATP-binding protein (247 aa) from Bacillus subtilis%2C fasta scores%3Bopt: 524%2C z-score: 615.6%2C E(): 4.8e-27%2C (39.3%25 identity in 234 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 161.50%2C E-value 1.4e-44 and Prosite matches to PS00017 ATP /GTP-binding%3D PS00211 ABC transporters family signature gene gene3987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3958 SCO3959 SCO3959 SCD78.26 SCD78.26 4358770 4359489 + hypothetical protein SCD78.26%2C possible integral membrane protein%2C len: 239 aa%2C possible membrane spanning regions gene gene3988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3959 SCO3960 SCO3960 SCD78.27c SCD78.27c 4359709 4360551 - hypothetical protein SCD78.27c%2C unknown%2C len: 280 aa%2C similar to family of hypothetical proteins e.g. TR:O07810 (EMBL:Z97188) hypothetical 28.5 kDa protein from Mycobacterium tuberculosis (273 aa)%2C fasta scores%3B opt: 597%2C z-score: 413.5%2C E(): 8.7e-164%2C 3.2%25 identity in 266 aa overlap. Also similar to SCD78.17c approx 9 kb downstream (37.9%25 identity in 285 aa overlap). Contains Pfam match to entry PF00592 DUF3%2C Domain of Unknown Function 3%2C score 96.90%2C E-value 4e-25 gene gene3989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3960 SCO3961 SCO3961 SCD78.28c SCD78.28c 4360548 4361825 - seryl-tRNA synthetase catalyzes a two-step reaction%2C first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene3990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3961 SCO3962 SCO3962 pheA pheA 4362335 4363267 - prephenate dehydratase SCD78.29c%2C pheA%2C prephenate dehydratase%2C len: 310 aa%2C similar to many eg. PHEA_AMYME (EMBL:L47666) prephenate dehydratase from Amycolatopsis methanolica (304 aa)%2C fasta scores%3B opt: 821%2C z-score: 1164.7%2C E(): 0%2C 46.9%25 identity in 305 aa overlap. Contains PS00857 Prephenate dehydratase signature 1 and Pfam match to entry PF00800 PDT%2C Prephenate dehydratase%2C score 354.80%2C E-value 9.5e-103. Note: Can participate in the biosynthesis of Phenylalanine%2C Tyrosine and Tryptophan gene gene3991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3962 SCO3963 SCO3963 SCD78.30c SCD78.30c 4363348 4364685 - hypothetical protein SCD78.30c%2C unknown%2C len: 445 aa%3B similar to YWBN_BACSU (EMBL:X73124) hypothetical protein 45.7kDa protein in epr-galK intergenic region precursor from Bacillus subtilis (416 aa)%2Cfasta scores%3B opt: 302%2C z-score: 556.3%2C E(): 9.7e-24%2C 35.6%25 identity in 432 aa overlap gene gene3992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3963 SCO3964 SCO3964 SCBAC25E3.01c SCBAC25E3.01c 4364694 4366736 - hypothetical protein SCBAC25E3.01c%2C possible integral membrane protein%2C len: >433aa: similar to TR:Q9AK64 (EMBL:AL583944) transport integral membrane protein 2SCD60.19 from Streptomyces coelicolor (589 aa) fasta scores%3B opt: 852%2C Z-score: 887.7%2C 51.646%25 identity (53.968%25 ungapped) in 395 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions.~SCD78.31c%2C unknown%2C partial CDS len: >180 aa%3B contains two hydrophobic domains%2C 6 degenerate repeats of (G /T)KAS and 4 degenerate repeats of TAKGSG gene gene3993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3964 SCO3965 SCO3965 SCBAC25E3.02c SCBAC25E3.02c 4366750 4367286 - hypothetical protein SCBAC25E3.02c%2C conserved hypothetical protein%2C len: 178aa: similar to many eg. TR:BAB50242 (EMBL:AP003001) MLL3326 protein from Rhizobium loti (179 aa) fasta scores%3B opt: 241%2C Z-score: 269.7%2C 38.333%25 identity (41.441%25 ungapped) in 120 aa overlap. gene gene3994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3965 SCO3966 SCO3966 SCBAC25E3.03c SCBAC25E3.03c 4367283 4367933 - hypothetical protein SCBAC25E3.03c%2C hypothetical protein%2C len: 216 aa: similar to many eg. TR:Q9RWR9 (EMBL:AE001918) conserved hypothetical protein from Deinococcus radiodurans (222 aa) fasta scores%3B opt: 329%2C Z-score: 384.3%2C 33.636%25 identity (37.949%25 ungapped) in 220 aa overlap. Contains Pfam match to entry PF02630 SCO1-SenC%2C SCO1/SenC. Contains possible N-terminal region signal peptide sequence gene gene3995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3966 SCO3967 SCO3967 SCBAC25E3.04c SCBAC25E3.04c 4368066 4368827 - hypothetical protein SCBAC25E3.04c%2C conserved hypothetical membrane protein%2C len: 253aa: similar to many eg. TR:Q9RPV8 (EMBL:AF142677) hypothetical protein from Bacillus megaterium plasmid pBM500 (211 aa) fasta scores%3B opt: 205%2C Z-score: 224.5%2C 28.745%25 identity (34.135%25 ungapped) in 247 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene3996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3967 SCO3968 SCO3968 SCBAC25E3.05c SCBAC25E3.05c 4368955 4369809 - hypothetical protein SCBAC25E3.05c%2C possible integral membrane protein%2C len: 284aa: similar to many from Streptomyces coelicolor eg. TR:Q9RCU (EMBL:AL136149) integral membrane protein SCM2.18c (256 aa) fasta scores%3B opt: 254%2C Z-score: 265.5%2C 37.631%25 identity (47.162%25 ungapped) in 287 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene3997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3968 SCO3969 SCO3969 SCBAC25E3.06c SCBAC25E3.06c 4370066 4370548 - ATP/GTP-binding protein SCBAC25E3.06%2C possible ATP/GTP-binding protein%2C len: 160 aa: no significant database matches. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene3998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3969 SCO3970 SCO3970 SCBAC25E3.07c SCBAC25E3.07c 4370586 4372061 - Xaa-Pro aminopeptidase SCBAC25E3.07c%2C Xaa-Pro aminopeptidase%2C len: 491aa: identical to SW:Q05813 (AMP1_STRLI) aminopeptidase P I from Streptomyces lividans (490 aa) fasta scores%3B opt: 3229%2C Z-score: 3571.1%2C 100.000%25 identity (100.000%25 ungapped) in 490 aa overlap. Similar to many others eg. SW:Q60394 (AMP2_STRCO) aminopeptidase P II from Streptomyces coelicolor (470 aa) fasta scores%3B opt: 2060%2C Z-score: 2279.7%2C 66.383%25 identity (67.241%25 ungapped) in 470 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24%2C metallopeptidase family M24 and Prosite match to PS00491 Aminopeptidase P and proline dipeptidase signature. gene gene3999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3970 SCO3971 SCO3971 SCBAC25E3.08c SCBAC25E3.08c 4372196 4373629 - hypothetical protein SCBAC25E3.08c%2C conserved hypothetical protein%2C len: 477 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RJ90 (EMBL:AL132973) hypothetical protein SCF91.35 (884 aa) fasta scores%3B opt: 458%2C Z-score: 470.1%2C 31.210%25 identity (34.507%25 ungapped) in 471 aa overlap gene gene4000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3971 SCO3972 SCO3972 SCBAC25E3.09 SCBAC25E3.09 4374285 4374950 + hypothetical protein SCBAC25E3.09%2C conserved hypothetical protein%2C len: 221aa: similar to TR:Q9K3U7 (EMBL:AL359988) conserved hypothetical protein SCD10.30c from Streptomyces coelicolor fasta scores%3B opt: 367%2C Z-score: 407.8%2C 35.354%25 identity (37.037%25 ungapped) in 198 aa overlap. gene gene4001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3972 SCO3973 SCO3973 SCBAC25E3.10 SCBAC25E3.10 4375006 4375671 + hypothetical protein SCBAC25E3.10%2C possible membrane protein%2C len: 221aa: no significant database matches. Contains a possible membrane-spanning hydrophobic region. gene gene4002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3973 SCO3974 SCO3974 SCBAC25E3.11c SCBAC25E3.11c 4375917 4376882 - hypothetical protein SCBAC25E3.11c%2C unknown%2C len: 321aa: contains Pfam match to entry PF02810 SEC-C%2C SEC-C motif. gene gene4003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3974 SCO3975 SCO3975 SCBAC25E3.12c SCBAC25E3.12c 4377505 4378143 - regulator SCBAC25E3.12c%2C possible regulator%2C len: 212 aa: similar to TR:Q53897 (EMBL:X60316) AbaA regulatory protein from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 225 %2C Z-score: 260.3%2C 33.333%25 identity (36.364%25 ungapped) in 156 aa overlap. gene gene4004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3975 SCO3976 SCO3976 SCBAC25E3.13c SCBAC25E3.13c 4378271 4379098 - phosphodiesterase SCBAC25E3.13c%2C possible phosphodiesterase%2C len: 275aa: similar to many eg. TR:Q9CDC5 (EMBL:AL583917) glycerophosphoryl diester phosphodiesterase from Mycobacterium leprae (271 aa) fasta scores%3B opt: 416%2C Z-score: 496.0%2C 46.269%25 identity (49.012%25 ungapped) in 268 aa overlap and SW:P37965 (GLPQ_BACSU) glycerophosphoryl diester phosphodiesterase from Bacillus subtilis (293 aa) fasta scores%3B opt: 233%2C Z-score: 281.0%2C 33.712%25 identity (36.777%25 ungapped) in 264 aa overlap. gene gene4005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3976 SCO3977 SCO3977 SCBAC25E3.14 SCBAC25E3.14 4379364 4380923 + protease SCBAC25E3.14%2C possible protease (hypothetical protein)%2C len: 519aa: similar to many eg. TR:Q9FBK9 (EMBL:AL390975) protease SCP8.12 from Streptomyces coelicolor (542 aa) fasta scores%3B opt: 1265%2C Z-score: 796.4%2C 43.636%25 identity (47.431%25 ungapped) in 550 aa overlap and TR:O06291 (EMBL:Z98260) HtrA from Mycobacterium tuberculosis (549 aa) fasta scores%3B opt: 614%2C Z-score: 396.6%2C 34.870%25 identity (37.826%25 ungapped) in 499 aa overlap. Contains Pfam match to entry PF00089 trypsin%2C Trypsin and Pfam match to entry PF00595 PDZ%2C PDZ domain (Also known as DHR or GLGF). Contains possible N-terminal region signal peptide sequence also possible hydrophobic membrane spanning region gene gene4006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3977 SCO3978 SCO3978 SCBAC25E3.15c SCBAC25E3.15c 4381065 4381949 - oxidoreductase SCBAC25E3.15c%2C possible oxidoreductase%2C len: 294aa: similar to many eg. TR:Q53929 (EMBL:X62373) ORF 4 from the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor (306 aa) fasta scores%3B opt: 624%2C Z-score: 633.9%2C 40.199%25 identity (41.581%25 ungapped) in 301 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and Prosite match to PS01162 Quinone oxidoreductase / zeta-crystallin signature. gene gene4007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3978 SCO3979 SCO3979 SCBAC25E3.16 SCBAC25E3.16 4382030 4382620 + TetR family transcriptional regulator SCBAC25E3.16%2C possible TetR-family transcriptional regulator%2C len: 196 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RK21 (EMBL:AL109974) TetR-family transcriptional regulator SCF34.04 (203 aa) fasta scores%3B opt: 497%2C Z-score: 587.5%2C 43.750%25 identity (44.681%25 ungapped) in 192 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene4008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3979 SCO3980 SCO3980 SCBAC25E3.17c SCBAC25E3.17c 4382898 4383473 - hypothetical protein SCBAC25E3.17c%2C unknown%2C len: 191 aa: no significant database matches. gene gene4010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3980 SCO3981 SCO3981 SCBAC25E3.18c SCBAC25E3.18c 4383616 4384371 - GntR family transcriptional regulator SCBAC25E3.18c%2C possible GntR-family transcriptional regulator%2C len: 251aa: similar to many eg. TR:Q07191 (EMBL:Z19589) KorSA regulatory protein from Streptomyces ambofaciens plasmid pSAM2 (259 aa) fasta scores%3B opt: 323%2C Z-score: 366.6%2C 30.952%25 identity (32.911%25 ungapped) in 252 aa overlap. Also strongly similar to TR:Q9X8E2 (EMBL:AL049573) GntR-family regulator SCE39.19 from Streptomyces coelicolor (251 aa) fasta scores%3B opt: 1603%2C Z-score: 1776.4%2C 96.386%25 identity (96.386%25 ungapped) in 249 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene4011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3981 SCO3982 SCO3982 SCBAC25E3.19 SCBAC25E3.19 4384451 4384729 + hypothetical protein SCBAC25E3.19%2C conserved hypothetical protein%2C len: 92 aa: strongly similar to TR:Q9X8E1 (EMBL:AL049573) hypothetical protein SCE39.18c from Streptomyces coelicolor (92 aa) fasta scores%3B opt: 471%2C Z-score: 618.1%2C 81.522%25 identity in 92 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation gene gene4012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3982 SCO3983 SCO3983 SCBAC25E3.20 SCBAC25E3.20 4384742 4385053 + hypothetical protein SCBAC25E3.20%2C unknown%2C len: 103 aa: no significant database matches. Contains TTA encoded leucine - possible target for bldA regulation. gene gene4013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3983 SCO3984 SCO3984 SCBAC25E3.21 SCBAC25E3.21 4385053 4385256 + hypothetical protein SCBAC25E3.21%2C conserved hypothetical protein%2C len: 67 aa: similar to TR:Q9X8D9 (EMBL:AL049573) hypothetical protein SCE39.16c from Streptomyces coelicolor (67 aa) fasta scores%3B opt: 257%2C Z-score: 349.2%2C 58.182%25 identity (58.182%25 ungapped) in 55 aa overlap. gene gene4014 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3984 SCO3985 SCO3985 SCBAC25E3.22 SCBAC25E3.22 4385253 4385477 + hypothetical protein SCBAC25E3.22%2C conserved hypothetical protein%2C len: 74 aa: similar to TR:Q9X8D8 (EMBL:AL049573) hypothetical protein SCE39.15c from Streptomyces coelicolor (74 aa) fasta scores%3B opt: 356%2C Z-score: 489.7%2C 77.465%25 identity (77.465%25 ungapped) in 71 aa overlap. gene gene4015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3985 SCO3986 SCO3986 SCBAC25E3.23 SCBAC25E3.23 4385486 4386217 + GntR family transcriptional regulator SCBAC25E3.23%2C possible GntR-family transcriptional regulator%2C len: 243 aa: similar to TR:Q9X8D7 (EMBL:AL049573) GntR-family regulator from Streptomyces coelicolor (243 aa) fasta scores%3B opt: 1025%2C Z-score: 1169.6%2C 67.083%25 identity (67.083%25 ungapped) in 240 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and Prosite match to PS00043 Bacterial regulatory proteins%2C gntR family signature. gene gene4016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3986 SCO3987 SCO3987 SCBAC25E3.24 SCBAC25E3.24 4386217 4386522 + hypothetical protein SCBAC25E3.22%2C conserved hypothetical protein%2C len: 101 aa: similar to TR:Q9X8D6 (EMBL:AL049573) hypothetical protein SCE39.13c from Streptomyces coelicolor (99 aa) fasta scores%3B opt: 441%2C Z-score: 546.5%2C 67.742%25 identity (67.742%25 ungapped) in 93 aa overlap gene gene4017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3987 SCO3988 SCO3988 SCBAC25E3.25 SCBAC25E3.25 4386552 4386899 + hypothetical protein SCBAC25E3.25%2C unknown%2C len: 115 aa: no significant database matches. gene gene4018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3988 SCO3989 SCO3989 SCBAC25E3.26 SCBAC25E3.26 4387240 4387509 + ribonuclease inhibitor SCBAC25E3.26%2C possible ribonuclease inhibitor%2C len: 89 aa: similar to SW:P11540 (BARS_BACAM) barstar (ribonuclease inhibitor) from Bacillus amyloliquefaciens (89 aa) fasta scores%3B opt: 141%2C Z-score: 198.8%2C 30.667%25 identity (30.667%25 ungapped) in 75 aa overlap. Contains Pfam match to entry PF01337 Barstar%2C Barstar (barnase inhibitor). gene gene4019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3989 SCO3990 SCO3990 SCBAC25E3.27c SCBAC25E3.27c 4387791 4388060 - hypothetical protein SCBAC25E3.27c%2C unknown%2C len: 89 aa: no significant database matches. gene gene4020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3990 SCO3991 SCO3991 SCBAC25E3.28c SCBAC25E3.28c 4388129 4389009 - gene gene4021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3991 SCO3992 SCO3992 SCBAC25E3.29c SCBAC25E3.29c 4389254 4389544 - hypothetical protein SCBAC25E3.29c%2C unknown%2C doubtful CDS%2C len: 96 aa: no significant database matches. gene gene4022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3992 SCO3993 SCO3993 SCBAC25E3.30c SCBAC25E3.30c 4389593 4389862 - hypothetical protein SCBAC25E3.30c%2C unknown%2C doubtful CDS%2C len: 89 aa: no significant database matches. gene gene4023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3993 SCO3994 SCO3994 SCBAC25E3.31 SCBAC25E3.31 4389919 4390131 + hypothetical protein SCBAC25E3.31%2C unknown%2C doubtful CDS%2C len: 70aa: no significant database matches. gene gene4024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3994 SCO3995 SCO3995 SCBAC25E3.32 SCBAC25E3.32 4390122 4390649 + partial replication initiator protein SCBAC25E3.32%2C partial possible replication initiator protein%2C len: 175 aa: similar to C-terminal region of many eg. SW:P36891 (REPS_STRAM) RepSA replication initiator protein from Streptomyces ambofaciens plasmid pSAM2 (459 aa) fasta scores%3B opt: 956%2C Z-score: 1170.4%2C 83.626%25 identity (83.626%25 ungapped) in 171 aa overlap. Gene may have been disrupted by translocation a event. gene gene4025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3995 SCO3996 SCO3996 SCBAC25E3.33 SCBAC25E3.33 4390652 4390861 + excisionase SCBAC25E3.33%2C possible excisionase%2C len: 69 aa: similar to many eg. SW:P15482 (VXIS_STRAM) excisionase Xis from Streptomyces ambofaciens plasmid pSAM2 (62 aa) fasta scores%3B opt: 93%2C Z-score: 151.3%2C 34.545%25 identity (34.545%25 ungapped) in 55 aa overlap. gene gene4026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3996 SCO3997 SCO3997 SCBAC25E3.34 SCBAC25E3.34 4390861 4392000 + integrase SCBAC25E3.34%2C possible integrase%2C len: >380aa: similar to many eg. SW:P22884 (VINT_BPML5) integrase int from Mycobacteriophage L5 (371 aa) fasta scores%3B opt: 448%2C Z-score: 506.7%2C 29.111%25 identity (31.304%25 ungapped) in 371 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. gene gene4027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3997 SCO3998 SCO3998 2SC10A7.02c 2SC10A7.02c 4392274 4393617 - hypothetical protein 2SC10A7.02c%2C unknown%2C len: 447 aa. Contains 3x Pfam matches to entry PF01011 Bacterial_PQQ%2C PQQ enzyme repeat gene gene4028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3998 SCO3999 SCO3999 2SC10A7.03 2SC10A7.03 4394003 4395133 + lipoprotein 2SC10A7.03%2C possible lipoprotein%2C len: 376 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene4029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO3999 SCO4000 SCO4000 2SC10A7.04c 2SC10A7.04c 4395100 4395579 - hypothetical protein 2SC10A7.04c%2C unknown%2C len: 159 aa gene gene4030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4000 SCO4001 SCO4001 2SC10A7.05c 2SC10A7.05c 4395671 4396546 - hypothetical protein 2SC10A7.05c%2C unknown%2C len: 291 aa gene gene4031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4001 SCO4002 SCO4002 2SC10A7.06 2SC10A7.06 4396912 4397238 + hypothetical protein 2SC10A7.06%2C possible hypothetical protein%2C len: 108 aa. Contains possible N-terminal region signal peptide sequence gene gene4032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4002 SCO4003 SCO4003 2SC10A7.07c 2SC10A7.07c 4397335 4397688 - hypothetical protein 2SC10A7.07c%2C unknown%2C len: 117 aa gene gene4033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4003 SCO4004 SCO4004 2SC10A7.08c 2SC10A7.08c 4397691 4397855 - small membrane protein 2SC10A7.08c%2C small membrane protein%2C len: 54 aa. Contains possible hydrophobic membrane spanning regions gene gene4034 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4004 SCO4005 SCO4005 2SC10A7.09 2SC10A7.09 4397899 4398372 + RNA polymerase sigma factor 2SC10A7.09%2C probable RNA polymerase sigma factor%2C len: 157 aa%3B similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE%2C 176 aa%3B fasta scores: opt: 451 z-score: 556.7 E(): 1.7e-23%3B 48.7%25 identity in 150 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 120..141 (+3.36 SD) gene gene4035 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4005 SCO4006 SCO4006 2SC10A7.10 2SC10A7.10 4398501 4400177 + long-chain-fatty-acid--CoA ligase activates fatty acids by binding to coenzyme A gene gene4036 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4006 SCO4007 SCO4007 2SC10A7.11c 2SC10A7.11c 4400250 4401542 - hypothetical protein 2SC10A7.11c%2C possible integral membrane protein%2C len: 430 aa%3B similar to TR:P96675 (EMBL:AB001488) Bacillus subtilis YdeR protein%2C 395 aa%3B fasta scores: opt: 611 z-score: 612.1 E(): 1.4e-26%3B 31.4%25 identity in 373 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4037 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4007 SCO4008 SCO4008 2SC10A7.12 2SC10A7.12 4401679 4402257 + tetR family regulatory protein 2SC10A7.12%2C probable tetR family regulatory protein%2C len: 192 aa%3B similar to TR:CAB93030 (EMBL:AL357432) Streptomyces coelicolor transcriptional regulator SCD95A.03c%2C 199 aa%3B fasta scores: opt: 345 z-score: 436.9 E(): 7.9e-17%3B 35.8%25 identity in 187 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene4038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4008 SCO4009 SCO4009 2SC10A7.13c 2SC10A7.13c 4402297 4406688 - bifunctional histidine kinase and regulator 2SC10A7.13c%2C possible bifunctional protein (histidine kinase and regulator)%2C len: 1463 aa%3B N-terminal region similar to TR:Q9RRR7 (EMBL:AE002072) Deinococcus radiodurans sensory box sensor histidine kinase DR2419%2C 744 aa%3B blastp scores: Score%3D 273 (96.1 bits)%2C Expect%3D 3.4e-19%2C Sum P(2)%3D 3.4e-19%3B Identities%3D 112/386 (29%25)%2C Positives%3D 170/386 (44%25) and C-terminal region similar to TR:Q9RKR9 (EMBL:AL133220) Streptomyces coelicolor multi-domain regulatory protein SCC75A.05c%2C 1334 aa%3B blastp scores: Score%3D 229 (80.6 bits)%2C Expect%3D 6.8e-14%2C Sum P(3)%3D 6.8e-14%3B Identitie %3D 100/311 (32%25)%2C Positives%3D 119/311 (38%25). Contains 2x Pfam matches to entry PF00989 PAS%2C PAS domain%2C Pfam match to entry PF00512 signal%2C Histidine kinase and to entry PF00072 response_reg%2C Response regulator receiver domain. Also contains a 5x degenerated repeat GQ and a 10x degenerated repeat: Q(G/A) and a possible N-terminal region signal peptide sequence gene gene4039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4009 SCO4010 SCO4010 2SC10A7.14c 2SC10A7.14c 4406863 4407330 - hypothetical protein 2SC10A7.14c%2C possible hypothetical protein%2C len: 155 aa%3B similar to C-terminal region of SW:SSI1_STRCI (PIR:PC1265) Streptomyces cacaoi subtilisin inhibitor-like protein-1 (Sil-1)%2C 110 aa%3B fasta scores: opt: 179 z-score: 206.6 E(): 0.00053%3B 36.1%25 identity in 97 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4010 SCO4011 SCO4011 2SC10A7.15 2SC10A7.15 4407941 4408414 + hypothetical protein 2SC10A7.15%2C possible integral membrane protein%2C len: 157 aa%3B identical to TR:Q04915 (EMBL:X70689) Streptomyces lividans ORF904 protein%2C 157 aa. Contains possible hydrophobic membrane spanning regions gene gene4043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4011 SCO4012 SCO4012 2SC10A7.16c 2SC10A7.16c 4408407 4408838 - hypothetical protein 2SC10A7.16c%2C possible integral membrane protein%2C len: 143 aa%3B almost identical to TR:Q04914 (EMBL:X70689) Streptomyces lividans ORFC310 protein%2C 143 aa. Contains possible hydrophobic membrane spanning regions gene gene4044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4012 SCO4013 SCO4013 2SC10A7.17 2SC10A7.17 4409067 4410554 + penicillin-binding protein 2SC10A7.17%2C probable penicillin-binding protein%2C len: 495 aa%3B similar to TR:Q9XA17 (EMBL:AL079308) Streptomyces coelicolor penicillin-binding protein SCH69.17%2C 490 aa%3B fasta scores: opt: 1733 z-score: 1829.7 E(): 0%3B 55.0%25 identity in 498 aa overlap and to TR:AAF61246 (EMBL:AF241575) Streptomyces griseus PbpA%2C 485 aa%3B fasta scores: opt: 1186 z-score: 1253.7 E(): 0%3B 55.8%25 identity in 495 aa overlap. Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible N-terminal region signal peptide sequence gene gene4045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4013 SCO4014 SCO4014 2SC10A7.18c 2SC10A7.18c 4410577 4410936 - hypothetical protein 2SC10A7.18c%2C conserved hypothetical protein%2C len: 119 aa%3B similar to SW:YTFH_ECOLI (EMBL:U14003) Escherichia coli hypothetical 14.1 kDa protein in RplI-CpdB intergenic region YtfH%2C 126 aa%3B fasta scores: opt 376 z-score: 479.2 E(): 3.5e-19%3B 56.1%25 identity in 98 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function DUF24 gene gene4046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4014 SCO4015 SCO4015 2SC10A7.19 2SC10A7.19 4410971 4411894 + hypothetical protein 2SC10A7.19%2C unknown%2C len: 307 aa. Contains a TTA leucine codon. Possible target for bldA regulation gene gene4047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4015 SCO4016 SCO4016 2SC10A7.20 2SC10A7.20 4412004 4412957 + hypothetical protein 2SC10A7.20%2C hypothetical protein%2C len: 317 aa%3B low similarity to TR:Q9XDF3 (EMBL:AF074603) Streptomyces griseus NonC protein%2C 317 aa%3B fasta scores: opt: 202 z-score: 235.7 E(): 1.3e-05%3B 26.9%25 identity in 238 aa overlap gene gene4048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4016 SCO4017 SCO4017 2SC10A7.21c 2SC10A7.21c 4413017 4413733 - iron dependent repressor 2SC10A7.21c%2C desR2%2C iron dependent repressor%2C len: 238 aa%3B highly similar to TR:CAB95905 (EMBL:AL359988) Streptomyces coelicolor iron repressor DesR%2C 230 aa%3B fasta scores: opt: 1140 z-score: 1122.3 E(): 0%3B 76.3%25 identity in 236 aa overlap and to SW:IDER_MYCTU (EMBL:U14191) Mycobacterium tuberculosis iron-dependent repressor IdeR%2C 230 aa%3B fasta scores: opt: 761 z-score: 754.0 E(): 0%3B 61.6%25 identity in 237 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress%2C Iron dependent repressor gene gene4049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4017 SCO4018 SCO4018 2SC10A7.22c 2SC10A7.22c 4413742 4414275 - hypothetical protein 2SC10A7.22c%2C conserved hypothetical protein%2C len: 177 aa%3B highly similar to SW:YL40_MYCTU (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 18.6 kDa protein MTCY270.28%2C 176 aa%3B fasta scores: opt: 672 z-score: 724.7 E(): 7.4e-33%3B 57.7%25 identity in 175 aa overlap. Contains Pfam match to entry PF01161 PBP%2C Phosphatidylethanolamine-binding protein gene gene4050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4018 SCO4019 SCO4019 2SC10A7.23 2SC10A7.23 4414377 4415069 + gntR family regulatory protein 2SC10A7.23%2C probable gntR family regulatory protein%2C len: 230 aa%3B similar to SW:YBPA_BURCE (EMBL:M86348) Burkholderia cepacia hypothetical transcriptional regulator in BphA 5' region%2C 245 aa%3B fasta scores: opt: 381 z-score: 442.5 E(): 3.8e-17%3B 36.0%25 identity in 211 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene4051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4019 SCO4020 SCO4020 2SC10A7.24 2SC10A7.24 4415129 4415944 + two component system response regulator 2SC10A7.24%2C probable two component system response regulator%2C len: 271 aa%3B similar to TR:O69730 (EMBL:AL022121) Mycobacterium tuberculosis two-component system regulator MTV025.113c%2C 234 aa%3B fasta scores: opt: 1111 z-score: 1309.2 E(): 0%3B 72.3%25 identity in 231 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene4052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4020 SCO4021 SCO4021 2SC10A7.25 2SC10A7.25 4415941 4417515 + two component system histidine kinase 2SC10A7.25%2C probable two component system histidine kinase%2C len: 524 aa%3B similar to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-)%2C 535 aa%3B fasta scores: opt: 481 z-score: 498.8 E(): 2.8e-20%3B 29.0%25 identity in 517 aa overlap. Contains Pfam match to entry PF00672 DUF5%2C HAMP domain and PF00512 signal%2C Histidine kinase. Also contains possible N-terminal region signal peptide sequence gene gene4053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4021 SCO4022 SCO4022 2SC10A7.26 2SC10A7.26 4417530 4418879 + glycosyl transferase 2SC10A7.26%2C probable glycosyl transferase%2C len: 449 aa%3B similar to N-terminal region of TR:AAF72730 (EMBL:AF265258) Rhodococcus sp. S9 dolichyl-phosphate beta-glucosyltransferase%2C 342 aa%3B fasta scores: opt: 1385 z-score: 1585.5 E(): 0%3B 66.0%25 identity in 326 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases and possible hydrophobic membrane spanning regions at C-terminal domain. Also contains a 5x degenerate repeat unit: PDPH(L/R) gene gene4054 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4022 SCO4023 SCO4023 2SC10A7.27 2SC10A7.27 4418876 4421077 + hypothetical protein 2SC10A7.27%2C possible integral membrane protein%2C len: 733 aa%3B similar to TR:O34575 (EMBL:Z99110) Bacillus subtilis YkcB protein%2C 716 aa%3B fasta scores: opt: 768 z-score: 610.1 E(): 1.8e-26%3B 29.8%25 identity in 742 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4023 SCO4024 SCO4024 2SC10A7.28 2SC10A7.28 4421136 4422659 + integral membrane efflux protein 2SC10A7.28%2C probable integral membrane efflux protein%2C len: 507 aa%3B highly similar to TR:Q54806 (EMBL:X84072) Streptomyces pristinaespiralis integral membrane protein Ptr%2C 501 aa%3B fasta scores: opt: 2316 z-score: 2400.3 E(): 0%3B 72.8%25 identity in 496 aa overlap and to TR:Q9XE01 (EMBL:AB019519) virginiamycin S resistance protein from Streptomyces virginiae (518 aa) fasta scores%3B opt: 1972%2C Z-score: 1995.4%2C 62.828%25 identity (63.992%25 ungapped) in 495 aa overlap. Contains matches to Prosite entries PS00216 Sugar transport proteins signature 1 and PS00012 Phosphopantetheine attachment site. Also contains possible hydrophobic membrane spanning region gene gene4056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4024 SCO4025 SCO4025 2SC10A7.29 2SC10A7.29 4422721 4423479 + TetR family transcriptional regulator 2SC10A7.29%2C probable tetR family transcriptional regulatory protein%2C len: 252 aa%3B similar to SW:TER4_ECOLI (EMBL:X01083) Escherichia coli tetracycline repressor protein class D TetR%2C 217 aa%3B fasta scores: opt: 193 z-score: 236.9 E(): 1.1e-05%3B 27.4%25 identity in 226 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 53..74 (+3.83 SD) gene gene4057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4025 SCO4026 SCO4026 2SC10A7.30c 2SC10A7.30c 4423549 4424019 - ATP binding protein 2SC10A7.30c%2C possible ATP binding protein%2C len: 156 aa%3B similar to TR:Q9XAG1 (EMBL:AL079356) Streptomyces coelicolor hypothetical 15.6 kDa protein SC6G9.21%2C 144 aa%3B fasta scores: opt: 278 z-score: 351.7 E(): 4.4e-12%3B 42.5%25 identity in 120 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4026 SCO4027 SCO4027 2SC10A7.31c 2SC10A7.31c 4424029 4424409 - anti sigma factor antagonist 2SC10A7.31c%2C probable anti sigma factor antagonist%2C len: 126 aa%3B similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist RsbV or BldG%2C 113 aa%3B fasta scores: opt: 131 z-score: 175.0 E(): 0.03%3B 30.4%25 identity in 102 aa overlap. Contains Pfam match to entry PF01740 STAS%2C STAS domain gene gene4059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4027 SCO4028 SCO4028 2SC10A7.32 2SC10A7.32 4424566 4425387 + hypothetical protein 2SC10A7.32%2C hypothetical protein%2C len: 273 aa%3B similar to TR:CAB76342 (EMBL:AL158061) Streptomyces coelicolor hypothetical 26.1 kDa protein SC6D11.19c%2C 236 aa%3B fasta scores: opt: 291 z-score: 349.8 E(): 5.6e-12%3B 33.0%25 identity in 221 aa overlap. Contains Pfam match to entry PF01590 GAF%2C GAF domain gene gene4060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4028 SCO4029 SCO4029 2SC10A7.33 2SC10A7.33 4425406 4426155 + hypothetical protein 2SC10A7.33%2C hypothetical protein%2C len: 249 aa%3B similar to TR:CAB76342 (EMBL:AL158061) Streptomyces coelicolor hypothetical 26.1 kDa protein SC6D11.19c%2C 236 aa%3B fasta scores: opt: 330 z-score: 392.0 E(): 2.5e-14%3B 32.7%25 identity in 226 aa overlap gene gene4061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4029 SCO4030 SCO4030 2SC10A7.34c 2SC10A7.34c 4426138 4426959 - hypothetical protein 2SC10A7.34c%2C hypothetical protein%2C len: 273 aa%3B similar to TR:Q9RDM0 (EMBL:AL136518) Streptomyces coelicolor hypothetical 31.6 kDa protein SCC123.04c%2C 293 aa%3B fasta scores: opt: 731 z-score: 837.9 E(): 0%3B 45.8%25 identity in 264 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4030 SCO4031 SCO4031 2SC10A7.35c 2SC10A7.35c 4427069 4429648 - integral membrane transport protein 2SC10A7.35c%2C probable integral membrane transport protein%2C len: 859 aa%3B similar to TR:Q9ZBJ1 (EMBL:AL035161) Streptomyces coelicolor efflux protein SC9C7.19%2C 815 aa%3B fasta scores: opt: 1355 z-score: 1335.4 E(): 0%3B 40.2%25 identity in 844 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and possible hydrophobic membrane spanning regions in N-terminal domain gene gene4063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4031 SCO4032 SCO4032 2SC10A7.36c 2SC10A7.36c 4429662 4430162 - marR regulatory protein 2SC10A7.36c%2C probable marR regulatory protein%2C len: 166 aa%3B similar to SW:MARR_ECOLI (EMBL:M96235) Escherichia coli multiple antibiotic resistance protein MarR%2C 125 aa%3B fasta scores: opt: 164 z-score: 211.9 E(): 0.00027%3B 27.3%25 identity in 110 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene4064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4032 SCO4033 SCO4033 2SC10A7.37 2SC10A7.37 4430278 4430568 + hypothetical protein 2SC10A7.37%2C possible membrane protein%2C len: 96 aa. Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene4065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4033 SCO4034 SCO4034 2SC10A7.38c 2SC10A7.38c 4430684 4431640 - RNA polymerase sigma factor 2SC10A7.38c%2C probable RNA polymerase sigma factor%2C len: 318 aa%3B highly similar to TR:Q9RIS5 (EMBL:AJ249581) Streptomyces coelicolor A3(2) Sig15 protein%2C 304 aa%3B fasta scores: opt: 1201 z-score: 1341.5 E(): 0%3B 66.6%25 identity in 287 aa overlap and to SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma-F factor SigF or RpoX%2C 287 aa%3B fasta scores: opt: 950 z-score: 1063.4 E(): 0%3B 58.6%25 identity in 261 aa overlap. Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and match to Prosite entry PS00715 Sigma-70 factors family signature 1. Also contains a possible helix-turn-helix motif at residues 284..305 (+6.30 SD) gene gene4066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4034 SCO4035 SCO4035 2SCD60.01c 2SCD60.01c 4431932 4432795 - RNA polymerase sigma factor 2SC10A7.39c%2C sigF%2C RNA polymerase sigma factor (fragment)%2C len: >31 aa%3B identical to previously sequenced SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma factor SigF or RpoX%2C 278 aa~2SCD60.01c%2C sigF%2C RNA polymerase sigma factor%2C len: 287 aa%3B identical to previously sequenced SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma factor sigma-F SigF or RpoX%2C 287 aa. Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and match to Prosite entry PS00715 Sigma-70 factors family signature 1. Also contains possible helix-turn-helix motif at residues 252..273 (+6.22 SD) gene gene4067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4035 SCO4036 SCO4036 2SCD60.02c 2SCD60.02c 4432988 4433281 - hypothetical protein 2SCD60.02c%2C hypothetical protein%2C len: 97 aa%3B identical to previously sequenced SW:YRPX_STRCO (EMBL:L11648) Streptomyces coelicolor hypothetical 11.1 kDa protein in RpoX 5' region%2C 97 aa gene gene4068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4036 SCO4037 SCO4037 2SCD60.03c 2SCD60.03c 4433281 4433457 - small membrane protein 2SCD60.03c%2C possible small membrane protein%2C len: 58 aa. Contains possible hydrophobic membrane spanning region gene gene4069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4037 SCO4038 SCO4038 2SCD60.04c 2SCD60.04c 4433708 4434139 - deaminase 2SCD60.04c%2C possible deaminase%2C len: 143 aa%3B similar to TR:AAG28837 (EMBL:AF160969) Bifidobacterium longum cytosine deaminase%2C 143 aa%3B fasta scores: opt: 553 z-score: 690.3 E(): 6.9e-31%3B 56.6%25 identity in 143 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam%2C Cytidine and deoxycytidylate deaminase zinc-binding region and match to Prosite entry PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature gene gene4071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4038 SCO4039 SCO4039 2SCD60.05c 2SCD60.05c 4434208 4434756 - hypothetical protein 2SCD60.05c%2C unknown%2C len: 182 aa gene gene4072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4039 SCO4040 SCO4040 2SCD60.06 2SCD60.06 4434929 4435393 + hypothetical protein 2SCD60.06%2C unknown%2C len: 154 aa gene gene4073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4040 SCO4041 SCO4041 upp upp 4435469 4436113 + uracil phosphoribosyltransferase Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate gene gene4074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4041 SCO4042 SCO4042 2SCD60.08c 2SCD60.08c 4436138 4436752 - hypothetical protein 2SCD60.08c%2C membrane protein%2C len: 204 aa%3B similar to TR:O07202 (EMBL:Z96072) Mycobacterium tuberculosis hypothetical 22.7 kDa protein MTCY05A6.21%2C 216 aa%3B fasta scores: opt: 193 z-score: 226.9 E(): 4.5e-05%3B 31.3%25 identity in 192 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4042 SCO4043 SCO4043 2SCD60.09c 2SCD60.09c 4436888 4437184 - hypothetical protein 2SCD60.09c%2C conserved hypothetical protein%2C len: 98 aa%3B similar to TR:O05823 (EMBL:Z95208) Mycobacterium tuberculosis hypothetical 12.0 kDa protein MTCY27.05c%2C 105 aa%3B fasta scores: opt: 419 z-score: 582.4 E(): 7e-25%3B 62.2%25 identity in 98 aa overlap gene gene4076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4043 SCO4044 SCO4044 2SCD60.10 2SCD60.10 4437234 4437938 + hypothetical protein 2SCD60.10%2C unknown%2C len: 234 aa gene gene4077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4044 SCO4045 SCO4045 2SCD60.11c 2SCD60.11c 4437969 4438649 - hypothetical protein 2SCD60.11c%2C possible integral membrane protein%2C len: 226 aa%3B similar to TR:O06141 (EMBL:Z95554) Mycobacterium tuberculosis hypothetical 20.4 kDa protein MTCY01B2.16c%2C 195 aa%3B fasta scores: opt: 628 z-score: 680.7 E(): 2.4e-30%3B 50.8%25 identity in 191 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4045 SCO4046 SCO4046 2SCD60.12c 2SCD60.12c 4438739 4439197 - hypothetical protein 2SCD60.12c%2C unknown%2C len: 152 aa gene gene4079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4046 SCO4047 SCO4047 2SCD60.13c 2SCD60.13c 4439198 4439791 - hypothetical protein 2SCD60.13c%2C conserved hypothetical protein%2C len: 197 aa%3B similar to TR:O06554 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 20.8 kDa protein MTCI65.23%2C 197 aa%3B fasta scores: opt: 741 z-score: 862.4 E(): 0%3B 60.6%25 identity in 188 aa overlap gene gene4080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4047 SCO4048 SCO4048 2SCD60.14c 2SCD60.14c 4439817 4440542 - hypothetical protein 2SCD60.14c%2C hypothetical protein%2C len: 241 aa%3B similar to TR:Q9RL28 (EMBL:AL121596) Streptomyces coelicolor hypothetical 28.7 kDa protein SCF51A.37%2C 259 aa%3B fasta scores: opt: 255 z-score: 307.0 E(): 1.5e-09%3B 30.2%25 identity in 225 aa overlap gene gene4081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4048 SCO4049 SCO4049 2SCD60.15 2SCD60.15 4440627 4442975 + antibiotic binding protein 2SCD60.15%2C probable antibiotic hydrolase%2C len: 782 aa%3B similar to SW:PAC2_PSES3 (EMBL:M18278) Pseudomonas sp. penicillin acylase II precursor (EC 3.5.1.11) AcyII%2C 773 aa%3B fasta scores: opt: 701 z-score: 597.1 E(): 1.1e-25%3B 33.5%25 identity in 841 aa overlap. Contains 3x Pfam matches to entry PF01804 Penicil_amidase%2C Penicillin amidase. Also contains 11x degenerate repeat (S/P)(E/K)(A/T)A(L/P)- and 4x degenerate repeat TP(L/E) gene gene4082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4049 SCO4050 SCO4050 2SCD60.16 2SCD60.16 4442968 4443588 + acetyltransferase 2SCD60.16%2C possible acetyltransferase%2C len: 206 aa%3B similar to TR:P94254 (EMBL:U61153) Bordetella bronchiseptica alcaligin biosynthesis protein AlcB%2C 201 aa%3B fasta scores: opt: 325 z-score: 399.6 E(): 1.1e-14%3B 37.2%25 identity in 183 aa overlap and to SW:AAC6_SERMA (EMBL:M23634) Serratia marcescens aminoglycoside N6'-acetyltransferase (EC 2.3.1.82) AacA4%2C 201 aa%3B fasta scores: opt: 155 z-score: 196.0 E(): 0.0023%3B 25.7%25 identity in 171 aa overlap gene gene4083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4050 SCO4051 SCO4051 2SCD60.17 2SCD60.17 4443585 4444082 + hypothetical protein 2SCD60.17%2C conserved hypothetical protein%2C len: 165 aa%3B similar to TR:P72845 (EMBL:D90901) Synechocystis sp. hypothetical 18.8 kDa protein SLL1188%2C 164 aa%3B fasta scores: opt: 339 z-score: 385.2 E(): 6.8e-14%3B 38.3%25 identity in 154 aa overlap gene gene4084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4051 SCO4052 SCO4052 2SCD60.18 2SCD60.18 4444079 4444873 + glucose 1-dehydrogenase 2SCD60.18%2C probable glucose 1-dehydrogenase%2C len: 264 aa%3B similar to SW:DHG2_BACME (EMBL:D90044) Bacillus megaterium glucose 1-dehydrogenase II (EC 1.1.1.47) GdhII%2C 261 aa%3B fasta scores: opt: 563 z-score: 619.9 E(): 5.7e-27%3B 38.7%25 identity in 256 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus gene gene4085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4052 SCO4053 SCO4053 2SCD60.19 2SCD60.19 4445276 4447045 + transport integral membrane protein 2SCD60.19%2C possible transport integral membrane protein%2C len: 589 aa%3B similar to TR:P94432 (EMBL:D50453) Bacillus subtilis homologue of copper export protein YcnJ%2C 541 aa%3B fasta scores: opt: 394 z-score: 369.0 E(): 5.4e-13%3B 27.8%25 identity in 442 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4053 SCO4054 SCO4054 2SCD60.20 2SCD60.20 4447284 4447970 + hypothetical protein 2SCD60.20%2C possible integral membrane protein%2C len: 228 aa. Contains possible hydrophobic membrane spanning regions gene gene4087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4054 SCO4055 SCO4055 2SCD60.21c 2SCD60.21c 4447967 4449100 - alcohol dehydrogenase 2SCD60.21c%2C probable alcohol dehydrogenase%2C len: 377 aa%3B similar to SW:FADH_PSEPU (EMBL:D21201) Pseudomonas putida glutathione-independent formaldehyde dehydrogenase (EC 1.2.1.46) FdhA%2C 398 aa%3B fasta scores: opt: 1048 z-score: 1080.0 E(): 0%3B 47.9%25 identity in 390 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and match to Prosite entry PS00059 Zinc-containing alcohol dehydrogenases signature gene gene4088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4055 SCO4056 SCO4056 2SCD60.22 2SCD60.22 4449241 4449432 + hypothetical protein 2SCD60.22%2C hypothetical protein%2C len: 63 aa. Contains possible N-terminal region signal peptide sequence gene gene4089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4056 SCO4057 SCO4057 2SCD60.23c 2SCD60.23c 4449455 4450345 - transport integral membrane protein 2SCD60.23c%2C probable transport integral membrane protein%2C len: 296 aa%3B similar to SW:AQP3_HUMAN (EMBL:AB001325) Homo sapiens aquaporin 3 Aqp3%2C 292 aa%3B fasta scores: opt: 571 z-score: 644.7 E(): 2.4e-28%3B 40.4%25 identity in 275 aa overlap. Contains Pfam match to entry PF00230 MIP%2C Major intrinsic protein and match to Prosite entry PS00221 MIP family signature gene gene4090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4057 SCO4058 SCO4058 2SCD60.24 2SCD60.24 4450575 4451078 + hypothetical protein 2SCD60.24%2C unknown%2C len: 167 aa gene gene4091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4058 SCO4059 SCO4059 2SCD60.25 2SCD60.25 4451075 4451410 + transcriptional regulator 2SCD60.25%2C possible transcriptional regulator%2C len: 111 aa%3B similar to TR:O86818 (EMBL:AL031031) Streptomyces coelicolor transcriptional regulator SC7C7.13%2C 124 aa%3B fasta scores: opt: 200 z-score: 263.0 E(): 4.4e-07%3B 43.3%25 identity in 97 aa overlap. Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family and possible helix-turn-helix motif at residues 30..51 (+4.25 SD) gene gene4092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4059 SCO4060 SCO4060 2SCD60.26 2SCD60.26 4451653 4452063 + hypothetical protein 2SCD60.26%2C unknown%2C len: 136 aa. Contains TTA leucine codon (136)%2C possible target for bldA regulation gene gene4093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4060 SCO4061 SCO4061 2SCD60.27c 2SCD60.27c 4452173 4452730 - hypothetical protein 2SCD60.27c%2C unknown%2C len: 185 aa gene gene4094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4061 SCO4062 SCO4062 2SCD60.28 2SCD60.28 4452748 4453257 + transposase 2SCD60.28%2C possible transposase%2C len: 169 aa%3B highly similar to N-terminal region of TR:Q9XAG8 (EMBL:AL079356) Streptomyces coelicolor transposase SC6G9.06c%2C 247 aa%3B fasta scores: opt: 880 z-score: 1055.6 E(): 0%3B 88.8%25 identity in 152 aa overlap gene gene4095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4062 SCO4063 SCO4063 2SCD60.29c 2SCD60.29c 4453499 4453855 - hypothetical protein 2SCD60.29c%2C possible hypothetical protein%2C len: 118 aa. Contains possible N-terminal region signal peptide sequence. Contains a TTA leucine codon (12)%2C possible target for bldA regulation gene gene4096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4063 SCO4064 SCO4064 2SCD60.30c 2SCD60.30c 4453888 4454151 - hypothetical protein 2SCD60.30c%2C unknown%2C len: 87 aa gene gene4097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4064 SCO4065 SCO4065 2SCD60.31c 2SCD60.31c 4454564 4455793 - transposase SCD25.01c%2Cpossible transposase%2C partial CDS%2C len: > 150 aa. Similar to many e.g. Methylobacterium sp TR:Q50409 (EMBL%3B X96995) transposase IS1357 (411 aa)%2C fasta scores opt: 239 z-score: 312.5 E(): 4.7e-10 38.2%25 identity in 131 aa overlap.~2SCD60.31c%2C possible regulatory protein (fragment)%2C len: >303 aa%3B similar to C-terminal region of TR:Q9JN56 (EMBL:U08223) Streptomyces fradiae regulation of tylosin production protein TylR%2C 430 aa%3B fasta scores: opt: 228 z-score: 266.0 E(): 3e-07%3B 26.7%25 identity in 288 aa overlap gene gene4098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4065 SCO4066 SCO4066 SCD25.02 SCD25.02 4455786 4456859 + hypothetical protein SCD25.02%2C unknown%2C len: 357 aa. gene gene4099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4066 SCO4067 SCO4067 dnaZ dnaZ 4457168 4459522 + DNA polymerase III subunits gamma and tau catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand%3B the tau chain serves as a scaffold to help in the dimerizaton of the alpha%2Cepsilon and theta core complex%3B the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA gene gene4102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4067 SCO4068 SCO4068 purD purD 4459642 4460892 + phosphoribosylamine--glycine ligase catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis gene gene4103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4068 SCO4069 SCO4069 SCD25.05 SCD25.05 4461199 4463193 + hypothetical protein SCD25.05%2C possible integral membrane protein%2C len: 664 aa. Contains a degenerate direct repeat region: residues 469_ PYADDEA P HAPYADDEA L HVPDADDEA P HAPYAD_502. Also contains possible membrane spanning hydrophobic domains. gene gene4104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4069 SCO4070 SCO4070 SCD25.06 SCD25.06 4463358 4464875 + hypothetical protein SCD25.06%2C unknown%2C len: 505 aa. gene gene4105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4070 SCO4071 SCO4071 hemH hemH 4464986 4465885 + phosphoribosylaminoimidazole-succinocarboxamide synthase catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis%3B SAICAR synthase gene gene4106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4071 SCO4072 SCO4072 SCD25.08c SCD25.08c 4466063 4466665 - LuxR family transcripitonal regulator SCD25.08c%2C luxR family two component system response regulator%2C len: 200. Highly similar to many e.g. Bacillus subtilis TR:O34723 (EMBL%3B AF027868)%2C fasta scores opt: 538 z-score: 609.7 E(): 1.3e-26 41.2%25 identity in 199 aa overlap and Streptomyces coelicolor TR:CAB46973 (EMBL%3B AL096825) two-component system response regulator SC6G3.01C (fragment) (202 aa)%2C fasta scores opt: 413 z-score: 356.7 E(): 1.3e-14 38.6%25 identity in 202 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and a Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Also contains a possible helix-turn-helix motif between residues 156..177. gene gene4108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4072 SCO4073 SCO4073 SCD25.09c SCD25.09c 4466674 4467921 - sensor kinase SCD25.09c%2C possible sensor kinase%2C len: 415 aa. Identical to Streptomyces lividans TR:Q04390 (EMBL:X65556) hypothetical protein in tRNA-glyU beta gene region (fragment) (>64 aa)%2C fasta scores opt: 436 z-score: 463.7 E(): 1.8e-18 100.0%25 identity in 64 aa overlap. Also similar to Streptomyces coelicolor TR:O70000 (EMBL:AL022374) two-component sensor SC5B8.14 (384 aa)%2C fasta scores opt: 303 z-score: 317.3 E(): 2.5e-10 26.8%25 identity in 400 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene4109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4073 SCO4074 SCO4074 SCD25.10c SCD25.10c 4467951 4468766 - hypothetical protein SCD25.10c%2C integral membrane protein%2C len: 271 aa. Identical to Streptomyces lividans TR:Q04320 (EMBL%3B X58873) hypothetical 28.3 kd protein in tRNA-glyU beta gene region (271 aa)%2C fasta scores opt: 1693 z-score: 1924.6 E():0 100.0%25 identity in 271 aa overlap and Streptomyces coelicolor TR:CAB50754 (EMBL%3B AL096839) integral membrane transport protein. Contains multiple possible membrane spanning hydrophobic domains. gene gene4110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4074 SCO4075 SCO4075 SCD25.11c SCD25.11c 4468763 4469743 - ABC transporter ATP-binding protein SCD25.11c%2C ABC transporter%2C ATP-binding subunit%2C len: 326 aa. Identical to Streptomyces lividans TR:Q04324 (EMBL%3B X58873) hypothetical 35.0 KD protein in tRNA-glyU beta gene region (326 aa)%2C fasta scores opt: 2092 z-score: 2329.9 E(): 0 100.0%25 identity in 326 aa overlap and Streptomyces coelicolor proteins TR:CAB50753 (EMBL%3B AL096839) ABC transporter%2C ATP-binding subunit SCC22.10 (307 aa)%2C fasta scores opt: 648 z-score: 727.6 E(): 0 42.1%25 identity in 309 aa overlap and TR:CAB42771 (EMBL%3B AL049841) ABC transporter%2C ATP-binding subunit SCI11.08 (315 aa)%2C fasta scores opt: 583 z-score: 447.5 E(): 1.1e-19 41.3%25 identity in 320 aa overlap. Contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C PS00211 ABC transporters family signature and a PS00017 ATP/GTP-binding site motif A (P-loop). gene gene4111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4075 SCO4076 SCO4076 SCD25.12c SCD25.12c 4470261 4470578 - LSR2-like protein SCD25.12c%2C LSR2-like protein%2C len: 105 aa. Highly similar to Streptomyces coelicolor TR:CAB40875 (EMBL%3B AL049628) LSR2-like protein SCE94.26C (111 aa)%2C fasta scores opt: 335 z-score: 425.4 E(): 2.4e-16 50.5%25 identity in 109 aa overlap and Mycobacterium leprae SW: LSR2_MYCLE (EMBL%3B M67510) LSR2 protein precursor (15 KD antigen) (112 aa)%2C fasta scores opt: 287 z-score: 367.2 E(): 4.2e-13 46.8%25 identity in 111 aa overlap. gene gene4113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4076 SCO4077 SCO4077 SCD25.13 SCD25.13 4470929 4471201 + phosphoribosylformylglycinamidine synthase subunit PurS With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide%2C ATP%2C and glutamine to formylglycinamidine ribonucleotide%2C ADP%2C and glutamate in the fourth step of the purine biosynthetic pathway gene gene4114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4077 SCO4078 SCO4078 purQ purQ 4471198 4471878 + phosphoribosylformylglycinamidine synthase I catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis gene gene4115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4078 SCO4079 SCO4079 purL purL 4471875 4474133 + phosphoribosylformylglycinamidine synthase II catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis gene gene4116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4079 SCO4080 SCO4080 SCD25.16c SCD25.16c 4474193 4474777 - hypothetical protein SCD25.16c%2C unknown%2C len: 194 aa. Shares a low level of similarity with Streptomyces coelicolor TR:CAB44517 (EMBL%3B AL078618) hypothetical 22.4 KD protein SC10A7.07 (199 aa)%2C fasta scores opt: 155 z-score: 201.1 E(): 0.00076 25.9%25 identity in 185 aa overlap. Also similar to TR:Q9L1Y1 (EMBL:AL138662) Streptomyces coelicolor hypothetical protein SC8E4A.24%2C 194 aa%3B fasta scores: opt: 705 Z-score: 859.5 E(): 3e-40%3B 57.576%25 identity in 198 aa overlap gene gene4117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4080 SCO4081 SCO4081 SCD25.17 SCD25.17 4474926 4475408 + hypothetical protein SCD25.17%2C unknown%2C len: 160 aa. gene gene4118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4081 SCO4082 SCO4082 SCD25.18 SCD25.18 4475477 4476316 + peptidase SCD25.18%2C possible peptidase%2C len: 279 aa. Shares a very low level of similarity%2C in parts%2C with two other Streptomyces coelicolor peptidases: TR:Q9ZBY3 (EMBL%3B AL034355) SCD78.16 (349 aa)%2C fasta scores opt: 199 z-score: 225.8 E(): 3.2e-05 44.3%25 identity in 79 aa overlap and TR:CAB40868 (EMBL%3B AL049628) SCE94.19C (228 aa)%2C fasta scores opt: 191 z-score: 219.8 E(): 6.8e-05 41.7%25 identity in 72 aa overlap. Contains a Pfam match to entry PF01551 Peptidase_M37 and a possible N-terminal signal sequence. gene gene4119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4082 SCO4083 SCO4083 SCD25.19 SCD25.19 4476421 4477734 + hypothetical protein SCD25.19%2C unknown%2C len: 437aa. gene gene4120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4083 SCO4084 SCO4084 SCD25.20 SCD25.20 4477740 4478348 + hypothetical protein SCD25.20%2C unknown%2C len: 437 aa. Similar in parts to Mycobacterium tuberculosis TR: O06627 (EMBL%3B Z95618) hypothetical 13.5 KD protein MTCY07H7A.02C (129 aa)%2Cfasta scores opt: 333 z-score: 391.1 E(): 2e-14 54.0%25 identity in 100 aa overlap and Mycobacterium leprae TR:O05761 (EMBL%3B Z95151) hypothetical 14.0 KD protein MLCB5.37 (131 aa)%2C fasta scores opt: 328 z-score: 385.3 E(): 4.1e-14 52.5%25 identity in 101 aa overlap. gene gene4121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4084 SCO4085 SCO4085 SCD25.21 SCD25.21 4478431 4479264 + lipoprotein SCD25.21%2C lipoprotein%2C len: 202 aa. Contains a possible N-terminal signal sequence and a Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene4122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4085 SCO4086 SCO4086 purF purF 4479261 4480853 + amidophosphoribosyltransferase Catalyzes first step of the de novo purine nucleotide biosynthetic pathway gene gene4123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4086 SCO4087 SCO4087 purM purM 4480933 4482000 + phosphoribosylaminoimidazole synthetase catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis gene gene4124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4087 SCO4088 SCO4088 SCD25.24c SCD25.24c 4482078 4482332 - hypothetical protein SCD25.24c%2C unknown%2C len: 84. Highly similar in N-terminus to Mycobacterium tuberculosis TR: O53824 (EMBL%3B AL022004) hypothetical 6.9 KD protein (60 aa)%2C fasta scores opt: 180 z-score: 231.6 E(): 1.5e-05 51.8%25 identity in 56 aa overlap. gene gene4125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4088 SCO4089 SCO4089 SCD25.25c SCD25.25c 4482654 4483748 - valine dehydrogenase SCD25.25c%2C valine dehydrogenase (EC 1.4.1.-)%2C len: 364 aa. Previously sequenced and characterised Streptomyces coelicolor SW:VDH_STRCO (EMBL%3B L13455) valine dehydrogenase (EC 1.4.1.-) (VALDH). Contains Pfam match to entry PF00208 GLFV_dehydrog%2C Glutamate/Leucine/Phenylalanine/Valine dehydrogenase and a Prosite hit to PS00074 Glu / Leu / Phe gene gene4126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4089 SCO4090 SCO4090 SCD25.26 SCD25.26 4483978 4484829 + hypothetical protein SCD25.26%2C unknown%2C len:283 aa. Previously sequenced Streptomyces coelicolor SW:YVDH_STRCO (EMBL%3B L13455) hypothetical 33.8 KD protein in VDH 3'region Orf1 (303 aa). gene gene4127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4090 SCO4091 SCO4091 SCD25.27 SCD25.27 4485363 4485569 + DNA-binding protein SCD25.27%2C possible DNA-binding protein%2C len: 68 aa. Contains a possible helix-turn-helix motif between residues 13..34 score +3.25 SD. gene gene4128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4091 SCO4092 SCO4092 hrpA hrpA 4486639 4490622 - ATP-dependent helicase SCD25.28c%2C ATP-dependent helicase%2C len: 1327 aa. Highly similar to Escherichia coli SW:HRPA_ECOLI (EMBL%3B D42105) ATP-dependent helicase (1281 aa)%2C fasta scores opt: 1818 z-score: 1967.4 E(): 0 61.9%25 identity in 1306 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene4130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4092 SCO4093 SCO4093 SCD25.29c SCD25.29c 4491092 4492711 - hypothetical protein SCD25.29c%2C possible integral membrane protein%2C len: 539 aa. Contains possible membrane spanning hydrophobic domains. gene gene4134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4093 SCO4094 SCO4094 SCD25.30 SCD25.30 4492828 4493178 + hypothetical protein SCD25.30%2C unknown%2C len: 116 aa. Highly similar to Mycobacterium tuberculosis TR:P96242 (EMBL%3B Z83864) hypothetical 15.0 KD protein (137 aa)%2C fasta scores opt: 395 z-score: 500.7 E(): 1.5e-20 54.4%25 identity in 114 aa overlap. Contains a Prosite hit to PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. gene gene4135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4094 SCO4095 SCO4095 SCD25.31 SCD25.31 4493275 4493832 + lipoprotein SCD25.31%2C possible lipoprotein%2C len: 185 aa. Contains a possible N-terminal signal sequence and a Prosite hit to a PS00013 Prokaryotic membrane lipoprotein lipid attachment site. The protein product is also predicted to be rich in Pro/Ala/Gly. gene gene4136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4095 SCO4096 SCO4096 SCD25.32 SCD25.32 4494136 4496358 + ATP-dependent RNA helicase SCD25.32%2C ATP-dependent RNA helicase%2C 839 aa. Highly similar to many including: Streptomyces coelicolor TR:O54116 (EMBL%3B AL021529) DEAD-box RNA helicase SC10A5.25C (498 aa)%2C fasta scores opt: 1467 z-score: 1347.1 E(): 0 50.0%25 identity in 486 aa overlap. Contains Pfam matches to entry PF00270 DEAD%2C DEAD/DEAH box helicase and Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain%2C as well as a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a degenerate direct repeat region: containing several different repeats: 6.5x RRDDRGDRGGRSF(D/E) 2x RRDDRRDDRGGRSFE 2x RRDDRGGF and a probable coiled-coil from 444 to 501 (58 residues). gene gene4137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4096 SCO4097 SCO4097 SCD17.01 SCD17.01 4496497 4498032 + amino acid/metabolite permease SCD17.01%2C possible amino acid/metabolite permease%2C partial CDS%2C len: >389 aa. Similar to many Eukaryotic permeases e.g. Arabidopsis thaliana TR: O22509 (EMBL%3B AF019637) amino acid or GABA permease (516 aa)%2C fasta scores opt: 827 z-score: 942.8 E(): 0 41.8%25 identity in 385 aa overlap as well as Escherichia coli SW:YEEF_ECOLI (EMBL%3B U00009) hypothetical 49.8 KD transport protein in sbcB-hisL intergenic region (454 aa)%2C fasta scores opt: 256 z-score: 295.7 E(): 4.1e-09 24.6%25 identity in 293 aa overlap. Contains a Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and multiple possible membrane spanning hydrophobic domains. The 5' region of this CDS is located on cosmid SCD25.~SCD25.33%2C possible integral membrane protein%2C partial CDS%2C len: 156 aa. High level of similarity with Eukaryotic permeases e.g. Arabidopsis thaliana TR:O22509 (EMBL%3B AF019637) amino acid or GABA permease (516 aa)%2C fasta scores opt: 470 z-score: 557.7 E(): 1e-23 53.1%25 identity in 128 aa overlap and Bacillus subtilis TR:O07576 (EMBL%3B Y14082) hypothetical 49.7 KD protein (456 aa)%2C fasta scores opt: 128 z-score: 158.4 E(): 0.18 23.3%25 identity in 133 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene4138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4097 SCO4098 SCO4098 SCD17.02c SCD17.02c 4498219 4498869 - acetyltransferase SCD17.02c%2C probable acetyltransferase%2C len: 216 aa. Highly similar to many acetyltransferases involved in antibiotic resistance e.g. Enterococcus faecium SW:SATA_ENTFC (EMBL%3B L12033) streptogramin A acetyltransferase (EC 2.3.1.-) (209 aa)%2C fasta scores opt: 610 z-score: 726.5 E(): 0 46.0%25 identity in 189 aa overlap and Enterococcus faecium TR:AAD44719 (EMBL%3B AF139725) SatG protein (214 aa)%2C fasta scores opt: 665 z-score: 790.9 E(): 0 53.7%25 identity in 188 aa overlap. It is also highly similar to Streptomyces coelicolor SC5G9.03c (217 aa)%2C fasta scores opt: 868 z-score: 924.4 E():0 62.0%25 identity in 205 aa overlap. Contains a Pfam match to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats). gene gene4140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4098 SCO4099 SCO4099 SCD17.03 SCD17.03 4499009 4499689 + tetR family transcriptional regulator SCD17.03%2C probable tetR family transcriptional regulator%2C len: 216 aa. Similar to many e.g. Propionibacterium freudenreichii TR:P72185 (EMBL:U51164) repressor protein (HemR) (259 aa)%2C fasta scores opt: 250 z-score: 297.6 E(): 3.2e-09 36.7%25 identity in 147 aa overlap. Also similar to several Streptomyces coelicolor regulators e.g. TR:O54180 (EMBL:AL021411) SC7H1.21 (203 aa)%2C fasta scores opt: 330 z-score: 391.0 E(): 2e-14 40.0%25 identity in 220 aa overlap and SC5G9.05 (193 aa)%2C fasta scores opt: 292 z-score: 269.9 E(): 9.2e-10 40.9%25 identity in 149 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a probable helix-turn-helix motif between residues 47..68 (+3.70 SD). gene gene4141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4099 SCO4100 SCO4100 SCD17.04 SCD17.04 4499727 4500119 + hypothetical protein SCD17.04%2C unknown%2C len: 130 aa. gene gene4142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4100 SCO4101 SCO4101 SCD17.05 SCD17.05 4500126 4500524 + hypothetical protein SCD17.05%2C possible hypothetical protein%2C len: 130 aa. Contains a possible N-terminal signal sequence. gene gene4143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4101 SCO4102 SCO4102 SCD17.06c SCD17.06c 4500505 4501464 - MerR family transcriptional regulator SCD17.06c%2C possible MerR family transcriptional regulator%2C len:319 aa. Similar to many other MerR family regulators e.g. Bradyrhizobium sp. (strain NC92) SW:NOLA_BRASN (EMBL%3B U33192) nodulation protein NolA (237 aa)%2C fasta scores opt: 251 z-score: 286.3 E(): 1.4e-08 28.9%25 identity in 225 aa overlap. Contains a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and a probable helix-turn-helix motif between residues 9..30 (+3.43 SD). gene gene4144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4102 SCO4103 SCO4103 SCD17.07c SCD17.07c 4501524 4502795 - peptidase SCD17.07c. probable peptidase%2C len : 423 aa. Similar to many e.g. Sulfolobus solfataricus SW:CBPX_SULSO (EMBL%3B Z48497) thermostable carboxypeptidase (EC 3.4.17.-) (393 aa)%2C fasta scores opt: 623 z-score: 708.6 E(): 4.1e-32 34.0%25 identity in 400 aa overlap. Contains a Pfam match to entry PF01546 Peptidase_M20. gene gene4145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4103 SCO4104 SCO4104 SCD17.08c SCD17.08c 4502820 4503476 - hypothetical protein SCD17.08c%2C possible integral membrane protein%2C len: 218 aa. Similar to several hypothetical membrane proteins e.g. Streptomyces coelicolor TR:O86576 (EMBL%3B AL031184) integral membrane protein SC2A11.15 (219 aa)%2C fasta scores opt: 503 z-score: 576.2 E(): 9.7e-25 41.6%25 identity in 209 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene4146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4104 SCO4105 SCO4105 SCD17.09 SCD17.09 4503887 4504207 + hypothetical protein SCD17.09%2C unknown%2C len: 106 aa. Highly similar to Streptomyces coelicolor TR:CAB40321 (EMBL%3B AL049573) hypothetical 10.8 KD protein SCE39.13C (99 aa)%2C fasta scores opt: 192 z-score: 253.4 E(): 9.3e-07 43.0%25 identity in 100 aa overlap. gene gene4147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4105 SCO4106 SCO4106 SCD17.10 SCD17.10 4504259 4505389 + bifunctional enzyme deaminase/reductase SCD17.10%2C possible bifunctional enzyme deaminase/reductase%2C len: 376 aa. Similar to both domains of the Escherichia coli bifunctional SW:RIBD_ECOLI (EMBL%3B X64395) riboflavin biosynthesis protein RibD (367 aa). However the N-terminal domain of SCD17.10 is similar to the E. coli C-terminal reductase domain%2C fasta scores opt: 209 z-score: 241.1 E(): 4.5e-06 27.0%25 identity in 222 aa overlap and the C-terminal domain of SCD17.10 is similar to the E. coli N-terminal deaminase domain (blast scores Expect %3D 3.2e-07%2C P %3D 3.2e-07%2C Identities %3D 51/192 (26%25)%2C Positives %3D 77/192 (40%25)). Also similar to other%2C hypothetical%2C deaminases e.g. Archaeoglobus fulgidus TR:O28272 riboflavin-specific deaminase (RibG) (219 aa)%2C fasta scores opt: 410 z-score: 471.2 E(): 6.8e-19 38.0%25 identity in 205 aa overlap. gene gene4148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4106 SCO4107 SCO4107 SCD17.11 SCD17.11 4505576 4506940 + hypothetical protein SCD17.11%2C possible integral membrane protein%2C len: 454 aa. Similar to many e.g. Streptomyces coelicolor TR:O69922 (EMBL%3B AL023861) integral membrane protein SC3C8.09 (367 aa)%2C fasta scores opt: 687 z-score: 689.9 E(): 4.5e-31 37.2%25 identity in 368 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains probable coiled coil between residues 270..307 (probability 0.85). gene gene4150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4107 SCO4108 SCO4108 SCD17.12 SCD17.12 4507333 4508376 + peptidase SCD17.12%2C probable peptidase%2C len: 347 aa. Similar to several Streptomyces coelicolor peptidases e.g. TR:CAB39706 (EMBL%3B AL049485) SC6A5.22 (312 aa)%2C fasta scores opt: 570 z-score: 526.9 E(): 5.4e-22 37.1%25 identity in 315 aa overlap and TR:CAB40868 (EMBL%3B AL049628) SCE94.19C (228 aa)%2C fasta scores opt: 460 z-score: 429.8 E(): 1.4e-16 40.1%25 identity in 217 aa overlap. Contains a Pfam match to entry PF01551 Peptidase_M37%2C an alanine rich region between residues 163..207 and a probable coiled coil between residues 149..219 (probability 1.00). gene gene4151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4108 SCO4109 SCO4109 SCD17.13 SCD17.13 4508515 4509459 + oxidoreductase SCD17.13%2C possible oxidoreductase%2C partial CDS%2C len: >136 aa. Similar to several including: Streptomyces fradiae TR:AAD41821 (EMBL%3B AF147704) NDP-Hexose 2%2C3-Enoyl reductase TYLCII (329 aa)%2C fasta scores opt: 251 z-score: 325.2 E(): 9.3e-11 41.9%25 identity in 124 aa overlap and Saccharopolyspora erythraea (Streptomyces erythraeus) TR:O33936 (EMBL%3B U77454)EryBII (333 aa)%2C fasta scores opt: 245 z-score: 317.5 E(): 2.5e-10 39.3%25 identity in 135 aa overlap.~SCD17A.01%2C possible oxidoreductase (fragment)%2C len: >218 aa%3B similar to TR:Q9RJC4 (EMBL:AL133171) Streptomyces coelicolor aldo/keto reductase (fragment) SCF81.28c%2C >307 aa%3B fasta scores: opt: 445 z-score: 528.2 E(): 6.5e-22%3B 39.7%25 identity in 219 aa overlap. Contains 2x Pfam matches to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene4152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4109 SCO4110 SCO4110 SCD17A.02c SCD17A.02c 4509484 4510875 - hypothetical protein SCD17A.02c%2C possible integral membrane protein%2C len: 463 aa. Contains possible hydrophobic membrane spanning regions gene gene4153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4110 SCO4111 SCO4111 trmB trmB 4510885 4511700 - tRNA (guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase%3B catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine gene gene4154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4111 SCO4112 SCO4112 SCD17A.04 SCD17A.04 4511815 4512225 + hypothetical protein SCD17A.04%2C unknown%2C len: 136 aa gene gene4155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4112 SCO4113 SCO4113 SCD17A.05c SCD17A.05c 4512311 4513591 - hydroxyglutarate oxidase catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate gene gene4156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4113 SCO4114 SCO4114 SCD17A.06c SCD17A.06c 4513662 4515083 - sporulation associated protein SCD17A.06c%2C sporulation associated protein%2C len: 473 aa%3B identical to previously sequenced TR:Q53958 (EMBL:M80614) Streptomyces coelicolor sporulation associated protein%2C 473 aa and similar to TR:Q9S2P4 (EMBL:AL096872) Streptomyces coelicolor regulator SC5F7.09c%2C 487 aa%3B fasta scores: opt: 728 z-score: 658.8 E(): 4.7e-31%3B 39.7%25 identity in 489 aa overlap. Contains a possible cleavable N-terminal region signal peptide sequence and a TTA leucine codon%2C possible target for bldA regulation gene gene4157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4114 SCO4115 SCO4115 SCD17A.07 SCD17A.07 4515796 4517919 + hypothetical protein SCD72A.01%2C unknown%2C partial CDS%2C len: >590 aa~SCD17A.07%2C possible hypothetical protein (fragment)%2C len: >151 aa. Contains possible and cleavable N-terminal region signal peptide sequence gene gene4158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4115 SCO4116 SCO4116 SCD72A.02 SCD72A.02 4517925 4521269 + AfsR-like regulatory protein SCD72A.02%2C possible AfsR-like regulatory protein%2C len: 1114 aa%3B similar to many from actinomycetes e.g. TR:CAB61705 (EMBL:AL133220) multi-domain regulatory protein from Streptomyces coelicolor (1334 aa) fasta scores%3B opt: 1324%2C z-score: 1364.5%2C E(): 0%2C 41.1%25 identity in 1357 aa overlap and SW:P25941 (AFSR_STRCO) regulatory protein AfsR from Streptomyces coelicolor (993 aa) fasta scores%3B opt: 533%2C z-score: 548.6%2C E(): 4.3e-23%2C 29.3%25 identity in 1014 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene4159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4116 SCO4117 SCO4117 SCD72A.03 SCD72A.03 4521256 4523319 - hypothetical protein SCD72A.03%2C possible membrane protein%2C len: 687aa%3B contains possible membrane-spanning hydrophobic region (358-453aa) and proline-rich region (495-540aa). gene gene4160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4117 SCO4118 SCO4118 SCD72A.04c SCD72A.04c 4523502 4524395 - TetR family transcriptional regulator SCD72A.04c%2C possible tetR-family transcriptional regulator%2C len: 297 aa%3B similar to many proposed transcriptional regulators e.g. TR:CAB58280 (EMBL:AL121849) tetR-family transcriptional regulator from Streptomyces coelicolor (194 aa) fasta scores%3B opt: 238%2C z-score: 239.0%2C E(): 7.5e-06%2C 32.3%25 identity in 189 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a helix-turn-helix motif 63-84 aa gene gene4161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4118 SCO4119 SCO4119 SCD72A.05 SCD72A.05 4524821 4526149 + NADH dehydrogenase SCD72A.05%2C possible NADH dehydrogenase%2C len: 442aa%3B similar to many eg. TR:Q9ZC17 (EMBL:AL033505) dehydrogenase from Streptomyces coelicolor SC1E6.05 (629 aa) fasta scores%3B opt: 893%2C z-score: 1049.2%2C E(): 0%2C 38.5%25 identity in 452 aa overlap and SW:P00393 (DHNA_ECOLI) NADH dehydrogenase Ndh (EC 1.6.99.3) from Escherichia coli (433 aa) fasta scores%3B opt: 404%2C z-score: 477.0%2C E(): 4.2e-19%2C 27.0%25 identity in 389 aa overlap. gene gene4162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4119 SCO4120 SCO4120 SCD72A.06 SCD72A.06 4526332 4527990 + hypothetical protein SCD72A.06%2C conserved hypothetical protein%2C len: 552 aa%3B similar in regions to many from Streptomyces coelicolor eg. TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein (860 aa) fasta scores%3B opt: 906%2C z-score: 1019.8%2C E(): 0%2C 43.5%25 identity in 370 aa overlap gene gene4163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4120 SCO4121 SCO4121 SCD72A.07c SCD72A.07c 4528045 4529322 - hypothetical protein SCD72A.07c%2C possible integral membrane protein%2C len: 425aa%3B contains possible membrane-spanning hydrophobic regions. Weakly similar to many eg. SW:P39843 (BMR2_BACSU) multidrug resistance protein 2 from Bacillus subtilis (400 aa) fasta scores%3B opt: 309%2C z-score: 339.7%2C E(): 1.9e-11%2C 22.8%25 identity in 394 aa overlap. gene gene4164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4121 SCO4122 SCO4122 SCD72A.08 SCD72A.08 4529468 4530016 + MarR family transcriptional regulator SCD72A.08%2C possible MarR-family transcriptional regulator%2C len: 182 aa%3B similar to many e.g. SW:P42195 (PECS_ERWCH) regulatory protein PecS from Erwinia chrysanthemi (166 aa) fasta scores%3B opt: 183%2C z-score: 231.8%2C E(): 1.9e-05%2C 24.3%25 identity in 152 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and Prosite match to PS00519 Bacterial regulatory proteins%2C asnC family signature gene gene4165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4122 SCO4123 SCO4123 SCD72A.09c SCD72A.09c 4535862 4536530 - two-component system response regulator SCD72A.09c%2C possible two-component system response regulator%2C len: 222aa%3B similar to many eg. TR:O86632 (EMBL:AL031155) possible two-component regulator from Streptomyces coelicolor (222 aa) fasta scores%3B opt: 973%2C z-score: 1128.5%2C E(): 0%2C 69.1%25 identity in 220 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature. gene gene4169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4123 SCO4124 SCO4124 SCD72A.10c SCD72A.10c 4536527 4537897 - two-component sensor kinase SCD72A.10c%2C possible two-component sensor kinase%2C len: 456aa%3B similar to many eg. TR:O86631 (EMBL:AL031155) two-component sensor kinase from Streptomyces coelicolor (429 aa) fasta scores%3B opt: 929%2C z-score: 995.1%2C E(): 0%2C 42.7%25 identity in 422 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase and possible membrane-spanning hydrophobic regions. Contains possible hydrophobic membrane spanning regions gene gene4170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4124 SCO4125 SCO4125 SCD72A.11 SCD72A.11 4537923 4538456 + acetyltransferase SCD72A.11%2C possible acetyltransferase%2C len: 177 aa%3B weakly similar to many eg. TR:AAD52985 (EMBL:AF140221) aminoglycoside 6'-N-acetyltransferase from Xanthomonas maltophilia (153 aa) fasta scores%3B opt: 128%2C z-score: 164.9%2C E(): 0.1%2C 28.7%25 identity in 115 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene4171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4125 SCO4126 SCO4126 SCD72A.12c SCD72A.12c 4538504 4539991 - hypothetical protein SCD72A.12c%2C possible membrane protein%2C len: 495aa%3B similar in regions to others from actinomycetes eg. TR:Q9X8A2 (EMBL:AL049645) hypothetical protein from Streptomyces coelicolor (427 aa) fasta scores%3B opt: 266%2C z-score: 260.7%2C E(): 4.7e-07%2C 27.7%25 identity in 296 aa overlap. Contains possible membrane-spanning hydrophobic region. gene gene4172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4126 SCO4127 SCO4127 SCD72A.13c SCD72A.13c 4540065 4541480 - ATP/GTP-binding protein SCD72A.13c%2C possible ATP/GTP-binding protein%2C len: 471 aa%3B similar to TR:CAB72383 (EMBL:AL138977) ATP-binding protein from Streptomyces coelicolor (507 aa) fasta scores%3B opt: 618%2C z-score: 740.6%2C E(): 0%2C 32.9%25 identity in 434 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4127 SCO4128 SCO4128 SCD72A.14c SCD72A.14c 4541493 4543034 - hypothetical protein SCD72A.14c%2C possible membrane protein%2C len: 513aa%3B similar to TR:Q9X871 (EMBL:AL049661) integral membrane protein from Streptomyces coelicolor (488 aa) fasta scores%3B opt: 220%2C z-score: 257.3%2C E(): 7.2e-07%2C 25.7%25 identity in 483 aa overlap. Contains possible membrane-spanning hydrophobic region. gene gene4174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4128 SCO4129 SCO4129 SCD72A.15c SCD72A.15c 4543049 4544311 - hypothetical protein SCD72A.15c%2C possible integral membrane protein%2C len: 420aa%3B contains possible membrane-spanning hydrophobic regions. gene gene4175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4129 SCO4130 SCO4130 SCD72A.16c SCD72A.16c 4544370 4545170 - hypothetical protein SCD72A.16c%2C possible membrane protein%2C len: 420aa%3B contains a possible membrane-spanning hydrophobic region. gene gene4176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4130 SCO4131 SCO4131 SCD72A.17c SCD72A.17c 4545338 4545646 - hypothetical protein SCD72A.17c%2C possible membrane protein%2C len: 420aa%3B contains possible membrane-spanning hydrophobic region. gene gene4177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4131 SCO4132 SCO4132 SCD72A.18 SCD72A.18 4546029 4547051 + transglycosylase SCD72A.18%2C possible transglycosylase%2C len: 340aa%3B similar to TR:CAB72389 (EMBL:AL138977) hypothetical protein from Streptomyces coelicolor (377 aa) fasta scores%3B opt: 310%2C z-score: 341.7%2C E(): 1.4e-11%2C 33.1%25 identity in 254 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family and Pfam match to entry PF01464 SLT%2C Transglycosylase SLT domain. Also contains a possible non-cleavable N-terminal signal sequence. gene gene4178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4132 SCO4133 SCO4133 SCD72A.19 SCD72A.19 4547257 4547973 + hypothetical protein SCD72A.19%2C possible integral membrane protein%2C len: 238aa%3B N-terminal region similar to others eg. TR:O86625 (EMBL:AL031155) integral membrane protein from Streptomyces coelicolor (201 aa) fasta scores%3B opt: 321%2C z-score: 379.3%2C E(): 1.1e-13%2C 35.8%25 identity in 179 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match to entry PF01569 PAP2%2C PAP2 superfamily gene gene4179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4133 SCO4134 SCO4134 SCD72A.20 SCD72A.20 4547977 4549560 - lipoprotein SCD84.01c%2C possible lipoprotein%2C len: >160 aa%3B similar to N-terminal region of TR:Q9X5Q4 (EMBL:AF127374) Streptomyces lavendulae MitR%2C 514 aa%3B fasta scores: opt: 274 z-score: 307.9 E(): 1.1e-09%3B 34.6%25 identity in 133 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence~SCD72A.20%2C possible lipoprotein%2C partial CDS%2C len: >403aa%3B forms C-terminus of TR:CAB88467 (EMBL:AL353816) on the overlapping Streptomyces coelicolor cosmid. Similar to many of undefined function eg. TR:Q9X5Q4 (EMBL:AF127374) from the mitomycin C biosynthetic cluster of Streptomyces lavendulae (514 aa) fasta scores%3B opt: 932%2C z-score: 1056.7%2C E(): 0%2C 37.1%25 identity in 412 aa overlap. Contains Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain. gene gene4180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4134 SCO4135 SCO4135 SCD84.02 SCD84.02 4550161 4551054 + lipoprotein SCD84.02%2C possible lipoprotein%2C len: 297 aa%3B similar to TR:CAB75314 (EMBL:AL139164) Streptomyces coelicolor lipoprotein SCC46.10%2C 285 aa%3B fasta scores: opt: 180 z-score: 203.0 E(): 0.00075%3B 22.4%25 identity in 232 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4135 SCO4136 SCO4136 SCD84.03c SCD84.03c 4551282 4551683 - hypothetical protein SCD84.03c%2C hypothetical protein%2C len: 133 aa%3B similar to TR:O06070 (EMBL:Z95398) Mycobacterium leprae hypothetical 15.2 kD protein MLCL622.07%2C 135 aa%3B fasta scores: opt: 374 z-score: 470.4 E(): 9.6e-19%3B 55.9%25 identity in 102 aa overlap gene gene4182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4136 SCO4137 SCO4137 SCD84.04 SCD84.04 4551891 4552511 + hypothetical protein SCD84.04%2C hypothetical protein%2C len: 206 aa%3B similar to TR:AAF10501 (EMBL:AE001945) Deinococcus radiodurans conserved hypothetical protein DR0924%2C 212 aa%3B fasta scores: opt: 347 z-score: 407.5 E(): 3.1e-15%3B 32.4%25 identity in 210 aa overlap. Contains Pfam match to entry PF01865 DUF47%2C Protein of unknown function gene gene4183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4137 SCO4138 SCO4138 pitH pitH 4552519 4553517 + phosphate transport protein SCD84.05%2C pitH%2C phosphate transport protein%2C len: 332 aa%3B similar to N-terminal region of SW:PITH_STRHA (EMBL:L05390) Streptomyces halstedii low-affinity inorganic phosphate transporter (fragment)%2C 213 aa%3B fasta scores: opt: 768 z-score: 850.1 E(): 0%3B 59.8%25 identity in 189 aa overlap%2C to TR:O30499 (EMBL:AF008187) Sinorhizobium meliloti phosphate transport protein%2C Pit%2C 334 aa%3B fasta scores: opt: 988 z-score: 1087.8 E(): 0%3B 48.3%25 identity in 327 aa overlap and to TR:CAB59459 (EMBL:AL132644) Streptomyces coelicolor hypothetical protein SCI8.28%2C 423 aa%3B fasta scores: opt: 991 z-score: 986.9 E(): 0%3B 45.9%25 identity in 331 aa overlap. Contains Pfam match to entry PF01384 PHO4%2C Phosphate transporter family. Contains also possible hydrophobic membrane spanning regions gene gene4184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4138 SCO4139 SCO4139 pstB pstB 4553637 4554413 - phosphate transporter ATP-binding protein ATP-binding protein%3B PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation gene gene4185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4139 SCO4140 SCO4140 pstA pstA 4554467 4555531 - phosphate ABC transporter permease SCD84.07c%2C pstA%2C phosphate ABC transport system permease%2C len: 354 aa%3B similar to TR:O86345 (EMBL:X75297) Mycobacterium tuberculosis phosphate transport system permease PstA1 aa%3B fasta scores: opt: 870 z-score: 1011.0 E(): 0%3B 48.4%25 identity in 281 aa overlap and to SW:PSTA_ECOLI (EMBL:X02723) Escherichia coli phosphate transport system permease PstA or PhoT%2C 296 aa%3B fasta scores: opt: 605 z-score: 705.5 E(): 7.7e-32%3B 37.2%25 identity in 277 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene4186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4140 SCO4141 SCO4141 pstC pstC 4555528 4556538 - phosphate ABC transporter permease SCD84.08c%2C pstC%2C phosphate ABC transport system permease%2C len: 336 aa%3B similar to TR:O86344 (EMBL:Z47983) Mycobacterium tuberculosis phosphate transport system permease PstC2%2C 324 aa%3B fasta scores: opt: 900 z-score: 993.3 E(): 0%3B 49.4%25 identity in 308 aa overlap and to SW:PSTC_ECOLI (EMBL:X02723) Escherichia coli phosphate transport system permease PstC or PhoW%2C 319 aa%3B fasta scores: opt: 667 z-score: 738.3 E(): 0%3B 40.5%25 identity in 311 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene4187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4141 SCO4142 SCO4142 pstS pstS 4556707 4557819 - phosphate-binding protein SCD84.09c%2C pstS%2C phosphate-binding protein precursor%2C len: 370 aa%3B similar to TR:O86343 (EMBL:Z95209) Mycobacterium tuberculosis phosphate-binding protein 3 precursor PstS3 or PhoS2%2C 370 aa%3B fasta scores: opt: 941 z-score: 994.7 E(): 0%3B 42.0%25 identity in 374 aa overlap and to SW:PSTS_ECOLI (EMBL:K01992) Escherichia coli phosphate-binding periplasmic protein precursor PstS or PhoS%2C 346 aa%3B fasta scores: opt: 451 z-score: 481.3 E(): 2.4e-19%3B 31.2%25 identity in 321 aa overlap. Contains Pfam match to entry PF01449 PstS%2C Phosphate-binding protein%2C correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and to entry PS00038 Myc-type%2C 'helix-loop-helix' dimerization domain signature. Contains also possible N-terminal region signal peptide sequence gene gene4188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4142 SCO4143 SCO4143 SCD84.10c SCD84.10c 4558121 4558549 - mutT-like protein SCD84.10c%2C possible mutT-like protein%2C len: 142 aa%3B similar to TR:O93721 (EMBL:U82368) Pyrobaculum aerophilum diadenosine 5'5'''-P1%2CP4-tetraphosphate pyrophosphohydrolase%2C 143 aa%3B fasta scores: opt: 169 z-score: 214.0 E(): 0.00018%3B 37.5%25 identity in 120 aa overlap%2C to TR:P96590 (EMBL:AB001488) Bacillus subtilis MutT protein%2C 149 aa%3B fasta scores: opt: 148 z-score: 189.0 E(): 0.0046%3B 28.2%25 identity in 110 aa overlap and to SW:MUTX_STRPN (EMBL:Z21702) Streptococcus pneumoniae mutator MutT protein (7%2C8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-DGTPAse) (EC 3.6.1.-) MutX%2C 154 aa%3B blastp scores: Score %3D 87 (30.6 bits)%2C Expect %3D 0.0081%2C P %3D 0.0080 Identities %3D 35/117 (29%25)%2C Positives %3D 54/117 (46%25). Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and match to Prosite entry PS00893 mutT domain signature gene gene4189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4143 SCO4144 SCO4144 SCD84.11c SCD84.11c 4558596 4559762 - hypothetical protein SCD84.11c%2C unknown%2C len: 388 aa%3B similar to TR:Q9EUS7 (EMBL:AJ243674) MutT Protein from Streptomyces griseus subsp. griseus (337 aa) fasta scores%3B opt: 357%2C Z-score: 350.5%2C E(): 6.9e-12%2C 53.403%25 identity (68.227%25 ungapped) in 382 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation. High %25 of G+C content gene gene4190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4144 SCO4145 SCO4145 ppk ppk 4559965 4562289 - polyphosphate kinase catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate gene gene4191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4145 SCO4146 SCO4146 SCD84.13 SCD84.13 4563131 4563673 + ECF family RNA polymerase sigma factor SCD84.13%2C probable ECF subfamily sigma factor%2C len: 180 aa%3B similar to TR:Q9WWP4 (EMBL:AF121850) Synechococcus sp. SigH%2C 199 aa%3B fasta scores: opt: 273 z-score: 333.6 E(): 4e-11%3B 37.4%25 identity in 163 aa overlap and to TR:O05767 (EMBL:U87307) Mycobacterium smegmatis extracytoplasmic function alternative sigma factor%2C SigE%2C 204 aa%3B fasta scores: opt: 261 z-score: 319.3 E(): 2.5e-10%3B 33.5%25 identity in 188 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene4192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4146 SCO4147 SCO4147 SCD84.14 SCD84.14 4563670 4564533 + hypothetical protein SCD84.14%2C possible integral membrane protein%2C len: 287 aa. Contains possible hydrophobic membrane spanning regions gene gene4193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4147 SCO4148 SCO4148 SCD84.15 SCD84.15 4564580 4565449 + ABC transporter ATP-binding protein SCD84.15%2C probable ABC transport system ATP-binding protein%2C len: 289 aa%3B similar to TR:AAF23811 (EMBL:AF213822) Zymomonas mobilis ABC binding protein%2C 298 aa%3B fasta scores: opt: 607 z-score: 650.5 E(): 8.9e-29%3B 38.6%25 identity in 285 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4148 SCO4149 SCO4149 SCD84.16 SCD84.16 4565446 4566975 + ABC transporter SCD84.16%2C possible ABC transport system transmembrane protein%2C len: 509 aa%3B N-terminal region similar to TR:CAB50958 (EMBL:AL096849) Streptomyces coelicolor ABC-transporter transmembrane protein SCI11.32%2C 239 aa%3B fasta scores: opt: 142 z-score: 168.1 E(): 0.066%3B 27.9%25 identity in 244 aa overlap. Contains possible hydrophobic membrane spanning regions in N-terminal region gene gene4195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4149 SCO4150 SCO4150 SCD84.17 SCD84.17 4566999 4567619 + ABC transporter SCD84.17%2C possible ABC transport system transmembrane protein%2C len: 206 aa%3B similar to TR:O69958 (EMBL:AL022268) Streptomyces coelicolor transmembrane transport protein SC4H2.03c%2C 411 aa%3B fasta scores: opt: 136 z-score: 161.5 E(): 0.16%3B 30.8%25 identity in 185 aa overlap. Contains possible hydrophobic membrane sapnning regions gene gene4196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4150 SCO4151 SCO4151 SCD84.18c SCD84.18c 4567662 4568591 - acetyltransferase SCD84.18c%2C possible acetyltransferase%2C len: 309 aa%3B similar to TR:O53831 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 33.6 kD protein MTV043.11%2C 315 aa%3B fasta scores: opt: 662 z-score: 773.0 E(): 0%3B 45.1%25 identity in 304 aa overlap and C-terminal region to SW:RIMI_ECOLI (EMBL:X06117) Escherichia coli ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128) RimI%2C 148 aa%3B fasta scores: opt: 159 z-score: 195.2 E(): 0.0021%3B 31.3%25 identity in 112 aa overlap. Contains 2x Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene4197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4151 SCO4152 SCO4152 SCD84.19 SCD84.19 4568800 4570638 + 5'-nucleotidase SCD84.19%2C possible 5'-nucleotidase%2C len: 612 aa%3B similar to SW:5NTD_DISOM (EMBL:X62278) Discopyge ommata 5'-nucleotidase precursor (EC 3.1.3.5) (ecto-nucleotidase)%2C 577 aa%3B fasta scores: opt: 322 z-score: 332.6 E(): 4.6e-11%3B 24.6%25 identity in 574 aa overlap. Contains Pfam match to entry PF01009 5_nucleotidase%2C 5'-nucleotidase and possible N-terminal region signal peptide sequence gene gene4198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4152 SCO4153 SCO4153 SCD84.20c SCD84.20c 4570805 4571188 - hypothetical protein SCD84.20c%2C hypothetical protein%2C len: 127 aa%3B similar to TR:CAB58283 (EMBL:AL121850) Streptomyces coelicolor conserved hypothetical protein SCC78.02%2C 123 aa%3B fasta scores: opt: 265 z-score: 344.9 E(): 9.4e-12%3B 40.2%25 identity in 107 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function gene gene4199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4153 SCO4154 SCO4154 SCD84.21 SCD84.21 4571295 4571696 + hypothetical protein SCD84.21%2C hypothetical protein%2C len: 142 aa%3B similar to TR:Q9ZBJ6 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.14c%2C 132 aa%3B fasta scores: opt: 186 z-score: 244.7 E(): 3.6e-06%3B 34.9%25 identity in 106 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C Domain of unknown function gene gene4200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4154 SCO4155 SCO4155 SCD84.22c SCD84.22c 4571671 4573116 - two-component system sensor SCD84.22c%2C probable two-component system sensor%2C len: 481 aa%3B similar to TR:O53895 (EMBL:AL021999) Mycobacterium tuberculosis two-component sensor%2C MTV044.10%2C 504 aa%3B fasta scores: opt: 884 z-score: 949.8 E(): 0%3B 39.4%25 identity in 482 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-)%2C 535 aa%3B fasta scores: opt: 404 z-score: 435.9 E(): 8e-17%3B 31.4%25 identity in 526 aa overlap. Contains Pfam matches to entries PF00672 DUF5%2C Domain found in bacterial signal proteins and PF00512 signal%2C Histidine kinase and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains possible hydrophobic membrane spanning regions gene gene4201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4155 SCO4156 SCO4156 SCD84.23c SCD84.23c 4573113 4573859 - two-component systen response regulator SCD84.23c%2C probable two-component systen response regulator%2C len: 248 aa%3B similar to SW:COPR_PSESM (EMBL:L05176) Pseudomonas syringae transcriptional activator protein CopR%2C 227 aa%3B fasta scores: opt: 610 z-score: 735.3 E(): 0%3B 42.7%25 identity in 227 aa overlap and to TR:O53894 (EMBL:AL021999) Mycobacterium tuberculosis two-component response regulator MTV044.09%2C 230 aa%3B fasta scores: opt: 933 z-score: 1119.0 E(): 0%3B 62.9%25 identity in 229 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene4202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4156 SCO4157 SCO4157 SCD84.24c SCD84.24c 4573948 4574991 - protease SCD84.24c%2C probable protease%2C len: 347 aa%3B similar to C-terminal region of TR:O06291(EMBL:Z98260) Mycobacterium tuberculosis HtrA%2C 549 aa%3B fasta scores: opt: 426 z-score: 370.9 E(): 3.4e-13%3B 38.4%25 identity in 328 aa overlap and C-terminal region similar to C-terminal region of SW:HTRA_ECOLI (EMBL:M36536) Escherichia coli protease do precursor HtrA%2C 474 aa%3B fasta scores: opt: 329 z-score: 290.0 E(): 1.1e-08%3B 42.7%25 identity in 199 aa overlap. Contains 2x Pfam match to entry PF00089 trypsin%2C Trypsin. Contains possible hydrophobic membrane spanning region gene gene4203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4157 SCO4158 SCO4158 SCD84.25c SCD84.25c 4575112 4576134 - LacI-family regulatory protein SCD84.25c%2C probable LacI-family regulatory protein%2C len: 340 aa%3B similar to TR:CAB66206 (EMBL:AL136502) Streptomyces coelicolor LacI-family transcriptional regulatory protein SCF43.17c%2C 341 aa%3B fasta scores: opt: 572 z-score: 669.2 E(): 8e-30%3B 37.3%25 identity in 338 aa overlap and to SW:CCPA_BACME (EMBL:L26052) Bacillus megaterium glucose-resistance amylase regulator (catabolite control protein) CcpA%2C 332 aa%3B fasta scores: opt: 564 z-score: 660.1 E(): 2.6e-29%3B 34.3%25 identity in 309 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and possible helix-turn-helix motif at residues 4..25 (+4.58 SD) gene gene4204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4158 SCO4159 SCO4159 glnR glnR 4576177 4576980 - transcriptional regulator SCD84.26c%2C glnR%2C transcriptional regulatory protein%2C len: 267 aa%3B identical to previously sequenced SW:GLNR_STRCO (EMBL:L03213) Streptomyces coelicolor transcriptional regulatory protein GlnR. Contains Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene4205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4159 SCO4160 SCO4160 SCD84.27 SCD84.27 4577223 4578059 + hydrolase SCD84.27%2C possible hydrolase%2C len: 278 aa%3B similar to TR:AAF25687 (EMBL:AF218823) Thermomonospora fusca dienelactone hydrolase DlhA%2C 265 aa%3B fasta scores: opt: 786 z-score: 885.1 E(): 0%3B 50.0%25 identity in 262 aa overlap gene gene4206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4160 SCO4161 SCO4161 SCD84.28 SCD84.28 4578096 4578350 + molybdopterin converting factor SCD84.28%2C possible molybdopterin converting factor%2C len: 84 aa%3B similar to TR:O53880 (EMBL:AL022004) Mycobacterium tuberculosis molybdopterin converting factor (subunit 1) MoaD-2%2C 92 aa%3B fasta scores: opt: 191 z-score: 269.0 E(): 1.6e-07%3B 45.9%25 identity in 85 aa overlap gene gene4207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4161 SCO4162 SCO4162 SCD84.29 SCD84.29 4578354 4579667 + hypothetical protein SCD84.29%2C possible integral membrane protein%2C len: 437 aa. High content in alanine%2C proline%2C glycine and glutamine amino acid residues. Contains possible hydrophobic membrane spanning domains in C-terminal region and degenerate amino acid repeat: 6x (R/P/Q)YDP(N/G) in N-terminal region gene gene4208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4162 SCO4163 SCO4163 SCD84.30 SCD84.30 4579824 4580561 + hypothetical protein SCD84.30%2C possible hypothetical protein%2C len: 245 aa. Contains possible N-terminal region signal peptide sequence gene gene4209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4163 SCO4164 SCO4164 cysA cysA 4580995 4581840 + thiosulfate sulfurtransferase SCD66.01%2C probable thiosulfate sulfurtransferase (fragment)%2C len: >168 aa%3B highly similar to SW:THTR_SACER (EMBL:M29612) Saccharopolyspora erythraea thiosulfate sulfurtransferase (EC 2.8.1.1) CysA%2C 281 aa%3B fasta scores: opt: 817 z-score: 966.7 E(): 0%3B 74.8%25 identity in 163 aa overlap and similar to SW:THTR_ECOLI (EMBL:D10496) Escherichia coli thiosulfate sulfurtransferase (EC 2.8.1.1) SseA%2C 280 aa%3B fasta scores: opt: 225 z-score: 273.5 E(): 9.2e-08%3B 28.2%25 identity in 163 aa overlap. Contains Pfam match to entry PF00581 Rhodanese%2C Rhodanese-like domain and match to Prosite entry PS00683 Rhodanese C-terminal signature~SCD84.31%2C cysA%2C thiosulfate sulfurtransferase (fragment)%2C len: >145 aa%3B highly similar to SW:THTR_SACE (EMBL:M29612) Saccharopolyspora erythraea thiosulfate sulfurtransferase (EC 2.8.1.1) (rhodanase-like protein) CysA%2C 281 aa%3B fasta scores: opt: 662 z-score: 820.8 E(): 0%3B 65.5%25 identity in 145 aa overlap. Contains Pfam match to entry PF00581 Rhodanese%2C Rhodanese-like domain gene gene4210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4164 SCO4165 SCO4165 SCD66.02 SCD66.02 4581874 4582161 + hypothetical protein SCD66.02%2C conserved hypothetical protein%2C len: 95 aa%3B similar to TR:Q54084 (EMBL:M29612) Saccharopolyspora erythraea hypothetical 10.2 kD protein%2C 101 aa%3B fasta scores: opt: 255 z-score: 316.1 E(): 3.9e-10%3B 46.3%25 identity in 95 aa overlap gene gene4211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4165 SCO4166 SCO4166 SCD66.03 SCD66.03 4582226 4582519 + hypothetical protein SCD66.03%2C possible integral membrane protein%2C len: 97 aa. Contains possible hydrophobic membrane spanning regions gene gene4212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4166 SCO4167 SCO4167 SCD66.04c SCD66.04c 4582548 4583216 - TetR family transcriptional regulator SCD66.04c%2C probable tetR-family transcriptional regulator%2C len: 222 aa%3B similar to TR:CAB90985 (EMBL:AL355832) Streptomyces coelicolor tetR-family transcriptional regulator SCE22.18c%2C 236 aa%3B fasta scores: opt: 436 z-score: 494.2 E(): 4.7e-20%3B 42.3%25 identity in 208 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif at residues 50..71 (+5.15 SD) gene gene4213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4167 SCO4168 SCO4168 SCD66.05 SCD66.05 4583238 4584065 + oxidoreductase SCD66.05%2C probable oxidoreductase%2C len: 275 aa%3B similar to TR:BAA95121 (EMBL:AB042262) Corynebacterium aquaticum levodione reductase Lvr%2C 267 aa%3B fasta scores: opt: 477 z-score: 478.6 E(): 3.5e-19%3B 37.3%25 identity in 260 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene4214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4168 SCO4169 SCO4169 SCD66.06 SCD66.06 4584106 4584870 + oxidoreductase SCD66.06%2C probable oxidoreductase%2C len: 254 aa%3B similar to SW:2BHD_STREX Streptomyces exfoliatus 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53)%2C 255 aa%3B fasta scores: opt: 1285 z-score: 1410.5 E(): 0%3B 77.6%25 identity in 255 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene4215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4169 SCO4170 SCO4170 SCD66.07 SCD66.07 4584935 4585840 + hypothetical protein SCD66.07%2C possible membrane protein%2C len: 301 aa. Contains possible hydrophobic membrane spanning region and high content in alanine amino acid residues gene gene4216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4170 SCO4171 SCO4171 SCD66.08 SCD66.08 4585837 4586589 + hypothetical protein SCD66.08%2C possible hypothetical protein%2C len: 250 aa. Contains possible N-terminal region signal peptide sequence and high content in alanine and glycine amino acid residues gene gene4217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4171 SCO4172 SCO4172 SCD66.09 SCD66.09 4586586 4587461 + hypothetical protein SCD66.09%2C possible membrane protein%2C len: 291 aa. Contains possible hydrophobic membrane spanning region and high content in alanine amino acid residues gene gene4218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4172 SCO4173 SCO4173 SCD66.10c SCD66.10c 4587481 4587828 - hypothetical protein SCD66.10c%2C unknown%2C len: 115 aa gene gene4219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4173 SCO4174 SCO4174 SCD66.11c SCD66.11c 4587872 4588123 - hypothetical protein SCD66.11c%2C possible integral membrane protein%2C len: 83 aa. Contains possible hydrophobic membrane spanning region gene gene4220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4174 SCO4175 SCO4175 SCD66.12c SCD66.12c 4588120 4588512 - hypothetical protein SCD66.12c%2C hypothetical protein%2C len: 130 aa%3B similar to TR:CAB69732 (EMBL:AL137166) Streptomyces coelicolor hypothetical 7.8 kD protein%2C 73 aa%3B fasta scores: opt: 180 z-score: 223.4 E(): 5.7e-05%3B 43.7%25 identity in 71 aa overlap gene gene4221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4175 SCO4176 SCO4176 SCD66.13 SCD66.13 4588684 4589526 + hypothetical protein SCD66.13%2C conserved hypothetical protein%2C len: 280 aa%3B similar to TR:O86676 (EMBL:AL031371) Streptomyces coelicolor hypothetical 30.7 kD protein SC4G2.03%2C 277 aa%3B fasta scores: opt: 378 z-score: 466.2 E(): 1.7e-18%3B 31.7%25 identity in 262 aa overlap gene gene4222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4176 SCO4177 SCO4177 SCD66.14 SCD66.14 4589532 4589801 + hypothetical protein SCD66.14%2C conserved hypothetical protein%2C len: 89 aa%3B similar to TR:CAB69735 (EMBL:AL137166) Streptomyces coelicolor hypothetical 10.2 kD protein SCC121.17%2C 96 aa%3B fasta scores: opt: 288 z-score: 395.7 E(): 1.4e-14%3B 50.0%25 identity in 78 aa overlap. Contains 2x degenerate repeat units: WRRSSYSN gene gene4223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4177 SCO4178 SCO4178 SCD66.15 SCD66.15 4589846 4589944 + small membrane protein SCD66.15%2C small membrane protein%2C len: 32 aa. Contains possible hydrophobic membrane spanning regions gene gene4224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4178 SCO4179 SCO4179 SCD66.16 SCD66.16 4589970 4590545 + hypothetical protein SCD66.16%2C hypothetical protein%2C len: 191 aa%3B similar to TR:O53827 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 23.9 kD protein MTV043.05c%2C 226 aa%3B fasta scores: opt: 320 z-score: 391.4 E(): 2.5e-14%3B 34.9%25 identity in 169 aa overlap gene gene4225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4179 SCO4180 SCO4180 SCD66.17 SCD66.17 4590561 4590998 + iron uptake regulatory protein SCD66.17%2C probable iron uptake regulatory protein%2C len: 145 aa%3B similar to SW:FUR_CAMJE (EMBL:X78965) Campylobacter jejuni ferric uptake regulation protein Fur%2C 157 aa%3B fasta scores: opt: 274 z-score: 366.6 E(): 6e-13%3B 31.9%25 identity in 135 aa overlap. Contains Pfam match to entry PF01475 FUR%2C Ferric uptake regulator family gene gene4226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4180 SCO4181 SCO4181 SCD66.18 SCD66.18 4591019 4591984 + hypothetical protein SCD66.18%2C conserved hypothetical protein%2C len: 321 aa%3B similar to TR:Q9RHX9 (EMBL:AB003158) Corynebacterium ammoniagenes ORF4%2C 359 aa%3B fasta scores: opt: 368 z-score: 441.2 E(): 4.2e-17%3B 38.9%25 identity in 319 aa overlap. Contains Pfam match to entry PF01571 GCV_T%2C Glycine cleavage T-protein (aminomethyl transferase) gene gene4227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4181 SCO4182 SCO4182 SCD66.19c SCD66.19c 4592011 4592436 - D-tyrosyl-tRNA(Tyr) deacylase hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)%3B possible defense mechanism against a harmful effect of D-tyrosine gene gene4228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4182 SCO4183 SCO4183 SCD66.20c SCD66.20c 4592459 4593478 - transposase SCD66.20c%2C probable transposase%2C len: 339 aa%3B identical to TR:CAB71807 (EMBL:AL138662) Streptomyces coelicolor transposase SC8E4.02%2C 339 aa gene gene4229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4183 SCO4184 SCO4184 amfC amfC 4593681 4594349 + aerial mycelium formation protein SCD66.21%2C amfC%2C aerial mycelium formation%2C len: 222 aa%3B identical to previously sequenced TR:Q54191 (EMBL:D63677) Streptomyces coelicolor aerial micelium formation AmfC%2C 222 aa gene gene4230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4184 SCO4185 SCO4185 SCD66.22 SCD66.22 4594466 4595476 + hypothetical protein SCD66.22%2C conserved hypothetical protein%2C len: 336 aa%3B highly similar to TR:Q54237 (EMBL:D63706) Streptomyces griseus ORF4 hypothetical protein%2C 328 aa%3B fasta scores: opt: 1654 z-score: 1801.0 E(): 0%3B 78.6%25 identity in 322 aa overlap and N-terminal domain identical to TR:Q9Z4H1 (EMBL:D63677) Streptomyces coelicolor ORF4 hypothetical protein (fragment)%2C 142 aa. Contains 3x degenerate repeat at N-terminal domain: PS(H/Q) gene gene4231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4185 SCO4186 SCO4186 SCD66.23 SCD66.23 4595605 4596861 + hypothetical protein SCD66.23%2C conserved hypothetical protein%2C len: 418 aa%3B highly similar to TR:Q54238 (EMBL:D63706%3B) Streptomyces griseus hypothetical protein ORF5%2C 416 aa%3B fasta scores: opt: 1720 z-score: 2020.0 E(): 0%3B 62.6%25 identity in 414 aa overlap gene gene4232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4186 SCO4187 SCO4187 2SCD46.01c 2SCD46.01c 4597040 4597225 - hypothetical protein 2SCD46.01c%2C membrane protein%2C partial CDS%2C len: >45aa%3B strongly similar to neighbouring CDS 2SCD46.03c fasta scores%3B opt: 169%2C z-score: 236.7%2C E(): 1.4e-07%2C 51.1%25 identity in 45 aa overlap. Hydrophobic. Contains possible hydrophobic membrane spanning regions~SCD66.24c%2C membrane protein (fragment)%2C len: >48 aa. Contains possible hydrophobic membrane spanning region gene gene4233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4187 SCO4188 SCO4188 2SCD46.02 2SCD46.02 4597379 4598290 + GntR family transcriptional regulator 2SCD46.02%2C possible GntR-family transcriptional regulator%2C len: 303aa%3B similar to many eg. TR:Q9RIQ2 (EMBL:AJ243257) KorA protein from plasmid pSNA1 of Streptomyces natalensis (245 aa) fasta scores%3B opt: 175%2C z-score: 204.2%2C E(): 0.00069%2C 28.2%25 identity in 238 aa overlap. Also strongly similar to neighbouring CDS 2SCD46.04 fasta scores%3B opt: 1074%2C z-score: 984.2%2C E(): 0%2C 57.6%25 identity in 302 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and helix-turn-helix motif (Score 1967 (+5.89 SD)) at residue 46-67. Note possible alternative downstream translational start codons. gene gene4234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4188 SCO4189 SCO4189 2SCD46.03c 2SCD46.03c 4598300 4598488 - hypothetical protein 2SCD46.03c%2C unknown%2C len: 62aa%3B strongly similar to neighbouring CDS 2SCD46.03c fasta scores%3B opt: 169%2C z-score: 236.7%2C E(): 1.4e-07%2C 51.1%25 identity in 45 aa overlap. Hydrophobic. gene gene4235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4189 SCO4190 SCO4190 2SCD46.04 2SCD46.04 4598629 4599504 + GntR family transcriptional regulator 2SCD46.04%2C possible GntR-family transcriptional regulator%2C len: 291aa%3B similar to many eg. TR:Q9RIQ2 (EMBL:AJ243257) KorA protein from plasmid pSNA1 of Streptomyces natalensis (245 aa) fasta scores%3B opt: 175%2C z-score: 209.9%2C E(): 0.00033%2C 29.9%25 identity in 194 aa overlap. Also strongly similar to neighbouring CDS 2SCD46.02 fasta scores%3B opt: 1074%2C z-score: 984.2%2C E(): 0%2C 57.6%25 identity in 302 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and helix-turn-helix motif (Score 2173 (+6.59 SD)) at residue 41-62. Note possible alternative downstream translational start codons. gene gene4236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4190 SCO4191 SCO4191 2SCD46.05 2SCD46.05 4599453 4600274 + hydrolase 2SCD46.05%2C possible hydrolase%2C len: 273aa%3B weakly similar to many proposed phosphatases eg. TR:CAB84916 (EMBL:AL162756) phosphatase from Neisseria meningitidis (235 aa) fasta scores%3B opt: 195%2C z-score: 238.2%2C E(): 8.8e-06%2C 29.5%25 identity in 237 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase. Note possible alternative downstream translational start codons. gene gene4237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4191 SCO4192 SCO4192 2SCD46.06 2SCD46.06 4600336 4601412 + hypothetical protein 2SCD46.06%2C unknown%2C len: 358aa gene gene4238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4192 SCO4193 SCO4193 2SCD46.07 2SCD46.07 4601497 4602498 + ATP/GTP-binding membrane protein 2SCD46.07%2C possible ATP/GTP-binding membrane protein%2C len: 333aa%3B N-terminal region weakly similar to SW:P07682 (LEPA_ECOLI) GTP-binding protein LepA from Escherichia coli (599 aa) fasta scores%3B opt: 142%2C z-score: 162.3%2C E(): 0.15%2C 22.9%25 identity in 341 aa overlap. Contains possible membrane-spanning hydrophobic regions Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene4239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4193 SCO4194 SCO4194 2SCD46.08 2SCD46.08 4602491 4603132 + TetR family transcriptional regulator 2SCD46.08%2C possible TetR-family transcriptional regulator%2C len: 213 aa%3B similar to many others from streptomycetes e.g. TR:CAB88457 (EMBL:AL353815) TetR-family transcriptional regulator from Streptomyces coelicolor (215 aa) fasta scores%3B opt: 369%2C z-score: 450.8%2C E(): 1.3e-17%2C 37.3%25 identity in 212 aa overlap and SW:P39885 (TCMR_STRGA) tetracenomycin c transcriptional repressor from Streptomyces glaucescens (226 aa) fasta scores%3B opt: 246%2C z-score: 303.8%2C E(): 2e-09%2C 36.7%25 identity in 166 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif (Score 1437 (+4.08 SD)) at residues 40..61 gene gene4240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4194 SCO4195 SCO4195 2SCD46.09 2SCD46.09 4603165 4605207 + ATP/GTP binding protein 2SCD46.09%2C possible ATP/GTP binding protein%2C len: 684aa%3B similar to TR:CAB93076 (EMBL:AL357432) ATP/GTP binding protein from Streptomyces coelicolor (681 aa) fasta scores%3B opt: 1940%2C z-score: 2059.2%2C E(): 0%2C 49.6%25 identity in 682 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene4241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4195 SCO4196 SCO4196 2SCD46.10c 2SCD46.10c 4605265 4606479 - organophosphate acid anhydrase 2SCD46.10c%2C possible organophosphate acid anhydrase%2C len: 404aa%3B similar to TR:Q50432 (EMBL:M91040) organophosphate acid anhydrase from Mycobacterium sp. (409 aa) fasta scores%3B opt: 762%2C z-score: 836.3%2C E(): 0%2C 44.8%25 identity in 402 aa overlap and TR:Q9S1C6 (EMBL:AB007293) organophosphorus insecticide hydrolase from Arthrobacter sp. (415 aa) fasta scores%3B opt: 705%2C z-score: 774.0%2C E(): 0%2C 42.6%25 identity in 408 aa overlap. gene gene4242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4196 SCO4197 SCO4197 2SCD46.11 2SCD46.11 4606581 4607048 + MarR family regulatory protein 2SCD46.11%2C possible MarR-family regulator%2C len: 155 aa%3B similar to many e.g. TR:Q9RK19 (EMBL:AL109974) MarR-family transcriptional regulator from Streptomyces coelicolor (168 aa) fasta scores%3B opt: 192%2C z-score: 240.7%2C E(): 6.4e-06%2C 34.2%25 identity in 149 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family. gene gene4243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4197 SCO4198 SCO4198 2SCD46.12 2SCD46.12 4607362 4607787 + DNA-binding protein 2SCD46.12%2C probable DNA-binding protein%2C len: 141 aa%3B N-terminal region similar to many eg. TR:O53759 (EMBL:AL021933) regulatory protein from Mycobacterium tuberculosis (140 aa) fasta scores%3B opt: 412%2C z-score: 503.0%2C E(): 1.6e-20%2C 56.6%25 identity in 113 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and two helix-turn-helix motifs%3B (Score 979 (+2.52 SD)) at residue 51-72 and (Score 1963 (+5.87 SD)) at residue 22-43. gene gene4244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4198 SCO4199 SCO4199 2SCD46.13 2SCD46.13 4607810 4608451 + hypothetical protein 2SCD46.13%2C unknown%2C len: 213aa%3B contains mostly hydrophilic residues. gene gene4245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4199 SCO4200 SCO4200 2SCD46.14 2SCD46.14 4608559 4608900 + hypothetical protein 2SCD46.14%2C possible membrane protein%2C len: 113aa%3B similar to SW:Q11143 (Y476_MYCTU) hypothetical protein from Mycobacterium tuberculosis (87 aa) fasta scores%3B opt: 212%2C z-score: 268.0%2C E(): 1.9e-07%2C 41.4%25 identity in 87 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene4246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4200 SCO4201 SCO4201 2SCD46.15c 2SCD46.15c 4609038 4610672 - hypothetical protein 2SCD46.15c%2C unknown%2C len: 544 aa%3B regions similar to many from Streptomyces coelicolor of undefined function e.g. TR:Q9RD37 (EMBL:AL133422) hypothetical protein (445 aa) fasta scores%3B opt: 887%2C z-score: 857.7%2C E(): 0%2C 41.4%25 identity in 423 aa overlap and TR:Q9X8X3 (EMBL:AL078610) regulatory protein (422 aa) fasta scores%3B opt: 325%2C z-score: 319.4%2C E(): 2.6e-10%2C 32.4%25 identity in 290 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain gene gene4247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4201 SCO4202 SCO4202 2SCD46.16c 2SCD46.16c 4610815 4611975 - hypothetical protein 2SCD46.16c%2C possible hypothetical protein%2C len: 386aa%3B similar to many from Streptomyces coelicolor eg. TR:Q9XAE3 (EMBL:AL079356) hypothetical protein (391 aa) fasta scores%3B opt: 781%2C z-score: 663.2%2C E(): 1.9e-29%2C 38.9%25 identity in 378 aa overlap. Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family%2C a possible cleavable N-terminal signal sequence and coiled-coil regions at 75-118 and 196-233 residues. gene gene4248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4202 SCO4203 SCO4203 2SCD46.17c 2SCD46.17c 4612173 4612988 - hypothetical protein 2SCD46.17c%2C unknown%2C len: 271aa gene gene4249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4203 SCO4204 SCO4204 2SCD46.18 2SCD46.18 4613136 4614626 + glycosyltransferase 2SCD46.18%2C possible glycosyltransferase%2C len: 496aa%3B strongly similar to SW:Q11152 (Y486_MYCTU) hypothetical protein from Mycobacterium tuberculosis (480 aa) fasta scores%3B opt: 932%2C z-score: 1025.3%2C E(): 0%2C 58.2%25 identity in 431 aa overlap. Also similar to proposed tranferases eg. TR:Q9Z5B7 (EMBL:AL035478) transferase from Streptomyces coelicolor (406 aa) fasta scores%3B opt: 438%2C z-score: 484.5%2C E(): 1.7e-19%2C 36.2%25 identity in 436 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1. gene gene4250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4204 SCO4205 SCO4205 2SCD46.19 2SCD46.19 4614619 4615125 + hypothetical protein 2SCD46.19%2C conserved hypothetical protein%2C len: 168aa%3B strongly similar to others from mycobacteria eg. SW:Q11153 (Y487_MYCTU) hypothetical protein from Mycobacterium tuberculosis (183 aa) fasta scores%3B opt: 508%2C z-score: 635.1%2C E(): 6.9e-28%2C 48.4%25 identity in 157 aa overlap gene gene4251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4205 SCO4206 SCO4206 2SCD46.20c 2SCD46.20c 4615154 4615969 - AraC family transcription regulator 2SCD46.20c%2C possible AraC-family transcriptional regulator%2C len: 271 aa%3B similar to many e.g. TR:CAB88172 (EMBL:AL352972) AraC-family transcriptional regulator from Streptomyces coelicolor (278 aa) fasta scores%3B opt: 434%2C z-score: 495.7%2C E(): 4e-20%2C 36.4%25 identity in 275 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. gene gene4252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4206 SCO4207 SCO4207 2SCD46.21 2SCD46.21 4616019 4616486 + hypothetical protein 2SCD46.21%2C conserved hypothetical protein%2C len: 155aa%3B similar to TR:Q98CG5 (EMBL:AP003005) MLR5159 protein from Rhizobium loti (Mesorhizobium loti) fasta scores%3B opt: 419%2C Z-score: 514.2%2C E(): 5.2e-21%2C 47.368%25 identity (47.368%25 ungapped) in 133 aa overlap. Note possible alternative downstream translational start site. gene gene4253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4207 SCO4208 SCO4208 2SCD46.22c 2SCD46.22c 4616569 4617858 - integral membrane transport protein 2SCD46.22c%2C possible integral membrane transport protein%2C len: 429aa%3B weakly similar to many membrane proteins eg. TR:O53854 (EMBL:AL022004) membrane protein from Mycobacterium tuberculosis (430 aa) fasta scores%3B opt: 382%2C z-score: 428.1%2C E(): 2.3e-16%2C 26.1%25 identity in 399 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and multiple possible membrane-spanning hydrophobic regions. gene gene4254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4208 SCO4209 SCO4209 gpmA gpmA 4618020 4618781 + 2%2C3-bisphosphoglycerate-dependent phosphoglycerate mutase 2%2C3-bisphosphoglycerate-dependent%3B catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate gene gene4255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4209 SCO4210 SCO4210 2SCD46.24c 2SCD46.24c 4618881 4619375 - hypothetical protein 2SCD46.24c%2C unknown%2C len: 164 aa gene gene4256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4210 SCO4211 SCO4211 2SCD46.25c 2SCD46.25c 4619432 4620040 - integrase%2C partial CDS 2SCD46.25c%2C possible integrase%2C partial CDS%2C len: 202aa%3B similar to the C-terminal region of many integrases many eg. SW:P09999 (INT2_ECOLI) integrase/recombinase (E2 protein) from plasmid IncN R46 of Escherichia coli (337 aa) fasta scores%3B opt: 160%2C z-score: 193.9%2C E(): 0.0025%2C 28.7%25 identity in 195 aa overlap and TR:O86766 (EMBL:AL031035) TraSA:integrase fusion protein from Streptomyces coelicolor (768 aa) fasta scores%3B .opt: 824%2C z-score: 963.6%2C E(): 0%2C 65.3%25 identity in 190 aa overlap. gene gene4257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4211 SCO4212 SCO4212 2SCD46.26 2SCD46.26 4620305 4620667 + hypothetical protein 2SCD46.26%2C unknown%2C len: 120 aa%3B similar to TR:Q9ACR7 (EMBL:AL590464) hypothetical protein from Streptomyces coelicolor (122 aa) fasta scores%3B opt: 369%2C Z-score: 454.9%2C E(): 1e-17%2C 52.000%25 identity (56.522%25 ungapped) in 125 aa overlap. gene gene4258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4212 SCO4213 SCO4213 2SCD46.27 2SCD46.27 4621091 4622725 + hypothetical protein 2SCD46.27%2C unknown%2C len: 544 aa%3B C-terminal region similar to that of SW:P24202 (MRR_ECOLI) Mrr restriction system protein from Escherichia coli (304 aa) fasta scores%3B opt: 199%2C z-score: 216.8%2C E(): 0.00013%2C 28.4%25 identity in 162 aa overlap. N-terminal region contains possible coiled-coil sequences residues (33-63 and 156-200) and two TTA encoded leucine residues which may be a target for bldA regulation. gene gene4259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4213 SCO4214 SCO4214 2SCD46.28c 2SCD46.28c 4622993 4623433 - AbaA-like regulatory protein 2SCD46.28c%2C possible AbaA-like regulatory protein%2C len: 146aa%3B similar to many from Streptomyces coelicolor eg. TR:Q53897 (EMBL:X60316) AbaA pleiotropic regulatory protein (192 aa) fasta scores%3B opt: 150%2C z-score: 206.3%2C E(): 0.0005%2C 30.7%25 identity in 140 aa overlap and TR:CAB76014 (EMBL:AL157916) AbaA-like regulatory protein (220 aa) fasta scores%3B opt: 159%2C z-score: 217.2%2C E(): 0.00012%2C 37.4%25 identity in 131 aa overlap. gene gene4260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4214 SCO4215 SCO4215 2SCD46.29 2SCD46.29 4623766 4624524 + GntR family transcriptional regulator 2SCD46.29%2C possible GntR-family regulatory protein%2C len: 252 aa%3B similar to many regulators of possible integrative plasmid origin e.g. TR:Q07191 (EMBL:Z19589) from plasmid pSAM2 of Streptomyces ambofaciens (259 aa) fasta scores%3B opt: 475%2C z-score: 554.1%2C E(): 2.1e-23%2C 34.6%25 identity in 246 aa overlap and TR:Q9X8D2 (EMBL:AL049573) KorSA%2C regulatory protein from Streptomyces coelicolor (259 aa) fasta scores%3B opt: 485%2C z-score: 565.6%2C E(): 4.9e-24%2C 35.0%25 identity in 257 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene4261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4215 SCO4216 SCO4216 2SCD46.30c 2SCD46.30c 4624587 4624796 - hypothetical protein 2SCD46.30c%2C unknown%2C len: 69 aa gene gene4262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4216 SCO4217 SCO4217 2SCD46.31c 2SCD46.31c 4624932 4625816 - hypothetical protein 2SCD46.31c%2C conserved hypothetical protein%2C len: 294 aa%3B similar to TR:P75863 (EMBL:AE000196) hypothetical protein from Escherichia coli (369 aa) fasta scores%3B opt: 244%2C z-score: 297.9%2C E(): 4e-09%2C 33.3%25 identity in 288 aa overlap. gene gene4263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4217 SCO4218 SCO4218 2SCD46.32 2SCD46.32 4625975 4626166 + small hydrophilic protein 2SCD46.32%2C possible small hydrophilic protein%2C len: 63 aa gene gene4264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4218 SCO4219 SCO4219 2SCD46.33 2SCD46.33 4626394 4627158 + dienelactone hydrolase family hydrolase 2SCD46.33%2C possible hydrolase (dienelactone hydrolase family)%2C len: 254aa%3B similar to many eg. SW:P27136 (TFE1_ALCEU) carboxymethylenebutenolidase I (EC 3.1.1.45) from Alcaligenes eutrophus (Ralstonia eutropha) (234 aa) fasta scores%3B opt: 215%2C z-score: 250.7%2C E(): 1.7e-06%2C 28.3%25 identity in 230 aa overlap and TR:CAB92202 (EMBL:AL356592) hydrolase from Streptomyces coelicolor (251 aa) fasta scores%3B opt: 754%2C z-score: 853.2%2C E(): 0%2C 48.4%25 identity in 248 aa overlap. Contains Pfam match to entry PF01738 DLH%2C Dienelactone hydrolase family. gene gene4265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4219 SCO4220 SCO4220 2SCD46.34c 2SCD46.34c 4627348 4627767 - hypothetical protein 2SCD46.34c%2C conserved hypothetical protein%2C len: 139aa%3B similar to others from actinomycetes eg. TR:CAB89437 (EMBL:AL354048) hypothetical protein from Streptomyces coelicolor (145 aa) fasta scores%3B opt: 105%2C z-score: 143.5%2C E(): 1.6%2C 37.0%25 identity in 146 aa overlap. gene gene4266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4220 SCO4221 SCO4221 2SCD46.35c 2SCD46.35c 4627832 4628248 - hypothetical protein 2SCD46.35c%2C unknown%2C len: aa gene gene4267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4221 SCO4222 SCO4222 2SCD46.36 2SCD46.36 4628357 4628737 + hypothetical protein 2SCD46.36%2C conserved hypothetical protein%2C len: 126aa%3B similar to others from actinomycetes eg. TR:O06633 (EMBL:Z95618) hypothetical protein from Mycobacterium tuberculosis (115 aa) fasta scores%3B opt: 256%2C z-score: 332.9%2C E(): 4.5e-11%2C 36.1%25 identity in 119 aa overlap. gene gene4268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4222 SCO4223 SCO4223 2SCD46.37c 2SCD46.37c 4628765 4629652 - AraC family transcription regulator 2SCD46.37c%2C possible AraC-family transcriptional regulator%2C len: 295aa%3B similar to many eg. SW:P22539 (SOXS_ECOLI) regulatory protein SoxS from Escherichia coli (106 aa) fasta scores%3B opt: 186%2C z-score: 223.7%2C E(): 5.4e-05%2C 28.4%25 identity in 95 aa overlap and TR:P96662 (EMBL:AB001488) probable hth_arac_family of transcriptional regulator from Bacillus subtilis (290 aa) fasta scores%3B opt: 726%2C z-score: 825.6%2C E(): 0%2C 37.7%25 identity in 289 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and Prosite match to PS00041 Bacterial regulatory proteins%2C araC family signature. gene gene4269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4223 SCO4224 SCO4224 2SCD46.38c 2SCD46.38c 4629724 4630989 - hypothetical protein 2SCD46.38c%2C unknown%2C len: 421aa gene gene4270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4224 SCO4225 SCO4225 2SCD46.39c 2SCD46.39c 4631073 4631465 - hypothetical protein 2SCD46.39c%2C possible integral membrane protein%2C len: 130aa%3B contains possible membrane-spanning hydrophobic regions. gene gene4271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4225 SCO4226 SCO4226 2SCD46.40c 2SCD46.40c 4631601 4631849 - hypothetical protein 2SCD46.40c%2C unknown%2C len: 82aa gene gene4272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4226 SCO4227 SCO4227 2SCD46.41c 2SCD46.41c 4631977 4632216 - hypothetical protein 2SCD46.41c%2C unknown%2C len: 421aa gene gene4273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4227 SCO4228 SCO4228 2SCD46.42c 2SCD46.42c 4632295 4632984 - phosphate transport system regulator SCD8A.01c%2C probable phosphate transport system regulatory protein (fragment)%2C len: >139 aa%3B similar to C-terminal region of TR:O53833 (EMBL:AL022004) Mycobacterium tuberculosis phosphate transport system regulatory protein%2C PhoY-2%2C 213 aa%3B fasta scores: opt: 383 z-score: 454.2 E(): 7.2e-18%3B 46.8%25 identity in 139 aa overlap and of SW:PHOU_ECOLI (EMBL:X02723) Escherichia coli phosphate transport system regulatory protein%2C PhoU%2C 241 aa%3B fasta scores: opt: 213 z-score: 258.9 E(): 5.5e-07%3B 28.1%25 identity in 128 aa overlap~2SCD46.42c%2C possible regulatory protein%2C partial CDS%2C len: >123aa%3B similar to the C-terminus of many proposed eg. phosphate transport regulators eg. TR:O53833 (EMBL:AL022004) phosphate transport system regulatory protein from Mycobacterium tuberculosis (213 aa) fasta scores%3B opt: 380%2C z-score: 494.5%2C E(): 4.4e-20%2C 52.9%25 identity in 104 aa overlap. gene gene4274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4228 SCO4229 SCO4229 SCD8A.02 SCD8A.02 4633199 4634479 + sensor kinase SCD8A.02%2C possible sensor kinase%2C len: 426 aa%3B similar to SW:SEX3_MYCTU (EMBL:Y13628) Mycobacterium tuberculosis sensor-like histidine kinase SenX3 (EC 2.7.3.-)%2C 410 aa%3B fasta scores: opt: 874 z-score: 939.7 E(): 0%3B 43.6%25 identity in 406 aa overlap and to C-terminal region of SW:PHOR_ECOLI (EMBL:X04704) Escherichia coli phosphate regulon sensor protein PhoR%2C 431 aa%3B fasta scores: opt: 521 z-score: 562.5 E(): 6.7e-24%3B 36.8%25 identity in 261 aa overlap%3B also similar to various S. coelicolor sensor proteins%2C e.g. SCH22A.18c%2C 370 aa%3B fasta scores: opt: 415 z-score: 388.1 E(): 3.9e-16%3B 31.1%25 identity in 383 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase and possible N-terminal region signal peptide sequence gene gene4275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4229 SCO4230 SCO4230 SCD8A.03 SCD8A.03 4634485 4635156 + response regulator SCD8A.03%2C probable response regulator%2C len: 223 aa%3B similar to TR:O86269 (EMBL:AJ001103) Lactococcus lactis ArcA protein%2C 233 aa%3B fasta scores: opt: 700 z-score: 810.0 E(): 0%3B 49.3%25 identity in 223 aa overlap and to TR:Q56180 (EMBL:U38917) Synechococcus sp. response regulator PhoB%2C 234 aa%3B fasta scores: opt: 687 z-score: 795.1 E(): 0%3B 48.0%25 identity in 229 aa overlap%2C and similar to many S. coelicolor response regulators%2C e.g. SCH22A.19c%2C 256 aa%3B fasta scores: opt: 687 z-score: 696.9 E(): 2.5e-33%3B 49.1%25 identity in 224 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene4276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4230 SCO4231 SCO4231 SCD8A.04c SCD8A.04c 4635317 4636042 - lipoprotein SCD8A.04c%2C possible lipoprotein%2C len: 241 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4231 SCO4232 SCO4232 SCD8A.05 SCD8A.05 4636744 4637226 + transcriptional factor regulator SCD8A.05%2C probable transcriptional factor regulator%2C len: 160 aa%3B similar to TR:O53568 (EMBL:AL022075) Mycobacterium tuberculosis transcriptional regulator RV3583c%2C 162 aa%3B fasta scores: opt: 878 z-score: 1046.7 E(): 0%3B 85.0%25 identity in 160 aa overlap gene gene4278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4232 SCO4233 SCO4233 ispD ispD 4637542 4638354 + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 4-diphosphocytidyl-2C-methyl-D-erythritol synthase%3B MEP cytidylyltransferase%3B MCT%3B catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate%3B involved in isoprenoid and isopentenyl-PP biosynthesis%3B forms homodimers gene gene4279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4233 SCO4234 SCO4234 ispF ispF 4638344 4638856 + 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate gene gene4280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4234 SCO4235 SCO4235 cysS cysS 4638881 4640722 + cysteinyl-tRNA synthetase catalyzes a two-step reaction%3B charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA gene gene4281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4235 SCO4236 SCO4236 SCD8A.09 SCD8A.09 4640855 4641799 + 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB SCD8A.09%2C possible tRNA/rRNA methyltransferase%2C len: 314 aa%3B similar to TR:P96861 (EMBL:Z92774) Mycobacterium tuberculosis hypothetical 34.0 kD protein MTCY06G11.26c%2C 322 aa%3B fasta scores: opt: 937 z-score: 1001.6 E(): 0%3B 56.7%25 identity in 319 aa overlap and to SW:YJFH_ECOLI (EMBL:U14003) Escherichia coli hypothetical tRNA/rRNA methyltransferase YjfH (EC 2.1.1.-)%2C 243 aa%3B fasta scores: opt: 519 z-score: 560.7 E(): 8.5e-24%3B 38.6%25 identity in 249 aa overlap. Contains Pfam match to entry PF00588 SpoU_methylase%2C SpoU rRNA Methylase family gene gene4282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4236 SCO4237 SCO4237 SCD8A.10 SCD8A.10 4641923 4643638 + hypothetical protein SCD8A.10%2C possible integral membrane protein%2C len: 571 aa. Contains possible hydrophobic membrane spanning regions gene gene4283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4237 SCO4238 SCO4238 SCD8A.11c SCD8A.11c 4643727 4644464 - guanyltransferase SCD8A.11%2C probable guanyltransferase%2C len: 245 aa%3B similar to TR:O93827 (EMBL:AF030299) Candida albicans mannose-1-phosphate guanyltransferase (EC 2.7.7.13) Psa1%2C 362 aa%3B fasta scores: opt: 396 z-score: 478.0 E(): 3.4e-19%3B 32.4%25 identity in 244 aa overlap and to SW:MPG1_YEAST (EMBL:U19608) Saccharomyces cerevisiae mannose-1-phosphate guanyltransferase (EC 2.7.7.13) Psa1%2C 361 aa%3B fasta scores: opt: 391 z-score: 472.0 E(): 7.3e-19%3B 31.6%25 identity in 244 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase%2C Nucleotidyl transferase gene gene4284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4238 SCO4239 SCO4239 SCD8A.12c SCD8A.12c 4644506 4644952 - small membrane protein SCD8A.12c%2C possible small membrane protein%2C len: 148 aa%3B similar to TR:P96484 (EMBL:Y08921) Streptomyces reticuli hypothetical 15.9 kD protein%2C MsiK%2C 152 aa%3B fasta scores: opt: 724 z-score: 885.9 E(): 0%3B 74.8%25 identity in 151 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4239 SCO4240 SCO4240 msiK msiK 4645175 4646311 - ABC transporter ATP-binding protein SCD8A.13c%2C msiK%2C ABC transporter ATP-binding protein%2C len: 378 aa%3B highly similar to TR:P96483 (EMBL:Y08921) Streptomyces reticuli gene encoding MsiK protein and ORF1%2C 377 aa%3B fasta scores: opt: 2268 z-score: 2471.1 E(): 0%3B 92.6%25 identity in 378 aa overlap and to SW:UGPC_ECOLI (EMBL:X13141) Escherichia coli sn-glycerol-3-phosphate transport ATP-binding protein UgpC%2C 365 aa%3B fasta scores: opt: 1031 z-score: 1127.4 E(): 0%3B 48.8%25 identity in 379 aa overlap also similar to TR:CAB46805 (EMBL:AL096811) Streptomyces coelicolor SCI30A.28c%2C 445 aa%3B fasta scores: opt: 866 z-score: 719.0 E(): 1.4e-34%3B 49.3%25 identity in 292 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4240 SCO4241 SCO4241 SCD8A.14c SCD8A.14c 4646671 4648308 - proteinase SCD8A.14c%2C possible proteinase precursor%2C len: 545 aa%3B similar to TR:Q54398 (EMBL:L42758) Streptomyces lividans proteinase SlpD%2C 539 aa%3B fasta scores: opt: 1116 z-score: 1193.2 E(): 0%3B 40.1%25 identity in 541 aa overlap and to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE%2C 513 aa%3B fasta scores: opt: 1004 z-score: 1074.0 E(): 0%3B 47.7%25 identity in 539 aa overlap%2C and to TR:Q54398 (EMBL:AL035636) Streptomyces coelicolor SCH5.02c%2C proteinase SlpD%2C 539 aa%3B fasta scores: opt: 1116 z-score: 1004.4 E(): 0%3B 40.1%25 identity in 541 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and correcty situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4241 SCO4242 SCO4242 SCD8A.15c SCD8A.15c 4648427 4649833 - hypothetical protein SCD8A.15c%2C possible membrane protein%2C len: 468 aa. Contains possible hydrophobic membrane spanning regions gene gene4289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4242 SCO4243 SCO4243 SCD8A.16c SCD8A.16c 4649830 4650402 - hypothetical protein SCD8A.16c%2C possible hypothetical protein%2C len: 190 aa. Contains possible N-terminal region signal peptide sequence gene gene4290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4243 SCO4244 SCO4244 SCD8A.17c SCD8A.17c 4650399 4652357 - hypothetical protein SCD8A.17c%2C unknown%2C len: 652 aa gene gene4291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4244 SCO4245 SCO4245 SCD8A.18c SCD8A.18c 4652357 4652809 - hypothetical protein SCD8A.18c%2C hypothetical protein%2C len: 150 aa%3B similar to TR:Q988W8 (EMBL:AP003009) MLR6561 protein from Rhizobium loti (Mesorhizobium loti) (136 aa) fasta scores%3B opt: 360%2C Z-score: 445.9%2C E(): 3.3e-17%2C 44.882%25 identity (47.107%25 ungapped) in 127 aa overlap. Also similar to TR:Q9ZXK9 (EMBL:AB008550) Pseudomonas aeruginosa phage phi CTX ORF17%2C 114 aa%3B fasta scores: opt: 172 z-score: 230.4 E(): 2.1e-05%3B 30.2%25 identity in 106 aa overlap gene gene4292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4245 SCO4246 SCO4246 SCD8A.19c SCD8A.19c 4652844 4654775 - hypothetical protein SCD8A.19c%2C unknown%2C len: 643 aa gene gene4293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4246 SCO4247 SCO4247 SCD8A.20c SCD8A.20c 4654775 4655497 - hypothetical protein SCD8A.20c%2C unknown%2C len: 240 aa. Contains Pfam match to entry PF01476 PG_binding_2%2C peptidoglycan binding domain gene gene4294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4247 SCO4248 SCO4248 SCD8A.21c SCD8A.21c 4655526 4655948 - hypothetical protein SCD8A.21c%2C unknown%2C len: 140 aa gene gene4295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4248 SCO4249 SCO4249 SCD8A.22 SCD8A.22 4656193 4656891 + hypothetical protein SCD8A.22%2C unknown%2C len: 232 aa gene gene4296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4249 SCO4250 SCO4250 SCD8A.23 SCD8A.23 4656901 4660236 + hypothetical protein SCD8A.23%2C unknown%2C len: 1111 aa%3B low similarity to C-terminal region of many glycine and alanine rich proteins%2C e.g. TR:Q9BIT7 (EMBL:AF350276) Nephila madagascariensis major ampullate spidroin 2-like protein (fragment) 1953 aa%3B fasta scores: opt: 883 Z-score: 635.4 E(): 9.3e-28%3B 31.167%25 identity in 1123 aa overlap. Rich in glycine and alanine residues gene gene4297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4250 SCO4251 SCO4251 SCD8A.24c SCD8A.24c 4660280 4660813 - hypothetical protein SCD8A.24c%2C possible hypothetical protein%2C len: 177 aa. Contains possible N-terminal region signal peptide sequence. gene gene4298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4251 SCO4252 SCO4252 SCD8A.25c SCD8A.25c 4660813 4661262 - hypothetical protein SCD8A.25c%2C unknown%2C len: 149 aa gene gene4299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4252 SCO4253 SCO4253 SCD8A.26c SCD8A.26c 4661315 4662919 - hypothetical protein SCD8A.26c%2C conserved hypothetical protein%2C len: 534 aa%3B similar to TR:Q988X8 (EMBL:AP003009) Rhizobium loti MLR6548 protein%2C 528 aa%3B fasta scores: opt: 1186 Z-score: 1203.4 E(): 2.1e-59%3B 39.963%25 identity in 538 aa overlap gene gene4300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4253 SCO4254 SCO4254 SCD8A.27 SCD8A.27 4663249 4666119 + hypothetical protein SCD8A.27%2C hypothetical protein%2C len: 956 aa%3B similar to C-terminal region of TR:CAB70627 (EMBL:AL137242) Streptomyces coelicolor large Ala/GLu-rich protein SC8F4.01c%2C 1326 aa%3B fasta scores: opt: 319 z-score: 268.7 E(): 1.6e-07%3B 25.1%25 identity in 798 aa overlap and to SW:TOLA_ECOLI (EMBL:M28232) Escherichia coli TolA protein%2C 421 aa%3B fasta scores: opt: 325 z-score: 280.1 E(): 3.6e-08%3B 38.4%25 identity in 255 aa overlap. Contains possible colied-coil region at aprox. residues 96..475. Rich in alanine and glutamic acid residues gene gene4301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4254 SCO4255 SCO4255 SCD8A.28 SCD8A.28 4666257 4666985 + hypothetical protein SCD8A.28%2C unknown%2C len: 242 aa gene gene4302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4255 SCO4256 SCO4256 SCD8A.29 SCD8A.29 4667076 4668515 + hydrolytic protein SCD8A.29%2C possible hydrolytic protein%2C len: 479 aa%3B similar to TR:Q9ZBF7 (EMBL:AL035206) Streptomyces coelicolor hydrolytic protein SC9B5.23c%2C 464 aa%3B fasta scores: opt: 1820 z-score: 1645.7 E(): 0%3B 70.9%25 identity in 423 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4256 SCO4257 SCO4257 SCD8A.30 SCD8A.30 4668591 4670033 + hydrolytic protein SCD8A.30%2C possible hydrolytic protein%2C len: 480 aa%3B similar to TR:Q9ZBF7 (EMBL:AL035206) Streptomyces coelicolor hydrolytic protein SC9B5.23c%2C 464 aa%3B fasta scores: opt: 1760 z-score: 1669.0 E(): 0%3B 63.0%25 identity in 487 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4257 SCO4258 SCO4258 SCD8A.31 SCD8A.31 4670132 4671589 + hydrolytic protein SCD8A.31%2C possible hydrolytic protein%2C len: 485 aa%3B similar to TR:Q9ZBF7 (EMBL:AL035206) Streptomyces coelicolor hydrolytic protein SC9B5.23c%2C 464 aa%3B fasta scores: opt: 1832 z-score: 1766.1 E(): 0%3B 66.1%25 identity in 492 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4258 SCO4259 SCO4259 SCD8A.32c SCD8A.32c 4671614 4673686 - ATPase AAA SCD8A.32c%2C possible AAA family ATPase%2C len: 690 aa%3B C-terminal region similar to TR:CAB74213 (EMBL:AL139075) Campylobacter jejuni probable AAA family ATPase CJ0377%2C 570 aa%3B fasta scores: opt: 378 z-score: 402.0 E(): 5.8e-15%3B 28.9%25 identity in 256 aa overlap and to SW:YB56_METJA (EMBL:U67557) Methanococcus jannaschii cell division cycle protein 48 homolog MJ1156%2C 903 aa%3B fasta scores: opt: 278 z-score: 293.2 E(): 6.7e-09%3B 30.4%25 identity in 240 aa overlap. Contains Pfam match to entry PF00004 AAA%2C ATPases associated with various cellular activities (AAA) and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4259 SCO4260 SCO4260 SCD49.01c SCD49.01c 4673692 4674369 - hypothetical protein SCD49.01c%2C hypothetical protein (fragment)%2C len: >115 aa%3B N-terminal part of TR:CAB77354 (EMBL:AL160331) Streptomyces coelicolor hypothetical 24.5 kD protein (fragment) SCD8A.33c%2C 224 aa and similar to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 7.4 kD protein MTCY22G10.13%2C 68 aa%3B fasta scores: opt: 71 z-score: 131.0 E(): 8%3B 41.0%25 identity in 39 aa overlap~SCD8A.33c%2C unknown (fragment)%2C len: >224 aa gene gene4307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4260 SCO4261 SCO4261 SCD49.02c SCD49.02c 4674563 4675222 - response regulator SCD49.02c%2C possible response regulator%2C len: 219 aa%3B similar to TR:O53646 (EMBL:AL021928) Mycobacterium tuberculosis response regulator MTV0033.03%2C 211 aa%3B fasta scores: opt: 383 z-score: 449.9 E(): 1.4e-17%3B 35.6%25 identity in 208 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family gene gene4308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4261 SCO4262 SCO4262 SCD49.03 SCD49.03 4675239 4675586 + hypothetical protein SCD49.03%2C unknown%2C len: 115 aa%3B doubtful CDS. Contains a TTA leucine codon%2C possible target for bldA regulation and high %25G+C (70.43) gene gene4309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4262 SCO4263 SCO4263 SCD49.04 SCD49.04 4675583 4679338 + transcriptional regulator SCD49.04%2C possible transcriptional regulatory protein%2C len: 1251 aa%3B N-terminal domain similar to TR:Q9RD3 (EMBL:AL133422) Streptomyces coelicolor transcriptional regulatory protein SCM1.10%2C 888 aa%3B blastp scores: Score %3D 154 (54.2 bits)%2C Expect %3D 5.7e-15%2C Sum P(2) %3D 5.7e-15 Identities %3D 120/425 (28%25)%2C Positives %3D 176/425 (41%25) and C-terminal domain similar to TR:Q9ZGI0 (EMBL:AF079139) Streptomyces venezuelae transcriptional activator PkiD%2C 928 aa%3B fasta scores: opt: 602 z-score: 498.1 E(): 2.9e-20%3B 29.0%25 identity in 815 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains a helix-turn-helix motif at residues 1196..1217 (+3.89 SD)%2C also a TTA leucine codon%2C possible target for bldA regulation and 4x degenerate repeat unit: (A/S)(A/S)AP(G/D)AAYXQAP(P/S)SDG(A/V)Y gene gene4310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4263 SCO4264 SCO4264 SCD49.05c SCD49.05c 4679364 4680236 - aminoglycoside phosphotransferase SCD86A.01c%2C aminoglycoside phosphotransferase (fragment)%2C len: >101 aa%3B highly similar to SW:HUR_STRAU (EMBL:M81739) Streptomyces aureofaciens hydroxyurea phosphotransferase (EC 2.7.-.-) Hur%2C 340 aa%3B fasta scores: opt: 413 z-score: 532.0 E(): 3.7e-22%3B 63.0%25 identity in 100 aa overlap~SCD49.05c%2C probable aminoglycoside phosphotransferase (fragment)%2C len: >223 aa%3B highly similar to SW:HUR_STRAU (EMBL:M81739) Streptomyces aureofaciens hydroxyurea phosphotransferase (EC 2.7.-.-) Hur%2C 340 aa%3B fasta scores: opt: 900 z-score: 1065.5 E(): 0%3B 61.1%25 identity in 221 aa overlap gene gene4311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4264 SCO4265 SCO4265 SCD86A.02c SCD86A.02c 4680295 4681806 - transport integral membrane protein SCD86A.02c%2C probable transport integral membrane protein%2C len: 503 aa%3B similar to SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii puromycin resistance protein Pur8%2C 503 aa%3B fasta scores: opt: 1772 z-score: 1875.8 E(): 0%3B 56.4%25 identity in 491 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and match to Prosite entry PS00216 Sugar transport proteins signature 1. Also contains possible hydrophobic membrane spanning regions gene gene4312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4265 SCO4266 SCO4266 SCD86A.03c SCD86A.03c 4681886 4682866 - oxidoreductase SCD86A.03c%2C probable oxidoreductase%2C len: 340 aa%3B similar to TR:Q53927 (EMBL:X62373) Streptomyces coelicolor genes for hydroxyacyl-CoA dehydrogenase%2C 329 aa%3B fasta scores: opt: 635 z-score: 652.9 E(): 6.7e-29%3B 37.9%25 identity in 335 aa overlap and to SW:QOR_ECOLI (EMBL:L02312) Escherichia coli quinone oxidoreductase (EC 1.6.5.5) Qor%2C 327 aa%3B fasta scores: opt: 395 z-score: 410.1 E(): 2.2e-15%3B 30.7%25 identity in 339 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene4313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4266 SCO4267 SCO4267 SCD86A.04c SCD86A.04c 4682918 4684078 - hypothetical protein SCD86A.04c%2C hypothetical protein%2C len: 386 aa%3B similar to TR:O06003 (EMBL:X86552) Bradyrhizobium japonicum hypothetical 46.6 kD protein%2C 439 aa%3B fasta scores: opt: 153 z-score: 175.4 E(): 0.027%3B 31.3%25 identity in 201 aa overlap gene gene4314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4267 SCO4268 SCO4268 SCD86A.05 SCD86A.05 4684159 4684947 + hypothetical protein SCD95A.01%2C unknown (fragment)%2C len: >25 aa~SCD86A.05%2C hypothetical protein %2C len: 262 aa%3B similar to SW:Y516_SYNY3 (EMBL:D64004) Synechocystis sp. hypothetical 17.9 kDa protein SLR0516%2C 166 aa%3B fasta scores: opt: 177 z-score: 209.9 E(): 0.00032%3B 34.5%25 identity in 142 aa overlap. Contains 3x Pfam matches to entry PF00805 Pentapeptide%2C Pentapeptide repeats (8 copies) gene gene4315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4268 SCO4269 SCO4269 SCD95A.02c SCD95A.02c 4684959 4685459 - hypothetical protein SCD95A.02c%2C unknown%2C len: 166 aa gene gene4316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4269 SCO4270 SCO4270 SCD95A.03c SCD95A.03c 4685643 4686242 - transcriptional regulator SCD95A.03c%2C possible transcriptional regulator%2C len: 199 aa%3B similar to TR:CAB53122 (EMBL:AL109962) Streptomyces coelicolor transcriptional regulatory protein SCJ1.04%2C 207 aa%3B fasta scores: opt: 154 z-score: 202.7 E(): 0.00079%3B 36.4%25 identity in 77 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene4317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4270 SCO4271 SCO4271 SCD95A.04 SCD95A.04 4686358 4687494 + NADP-dependent alcohol dehydrogenase SCD95A.04%2C probable NADP-dependent alcohol dehydrogenase%2C len: 378 aa%3B similar to SW:ADH_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis NADP-dependent alcohol dehydrogenase (EC 1.1.1.2) Adh%2C 346 aa%3B fasta scores: opt: 986 z-score: 1074.5 E(): 0%3B 45.0%25 identity in 349 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and match to Prosite entry PS00059 Zinc-containing alcohol dehydrogenases signature gene gene4318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4271 SCO4272 SCO4272 SCD95A.05 SCD95A.05 4687504 4688475 + mutT-like protein SCD95A.05%2C possible mutT-like protein%2C len: 323 aa%3B similar to TR:O69888 (EMBL:AL023797) Streptomyces coelicolor hypothetical 19.4 kD protein SC2E1.17 or MutT%2C 172 aa%3B fasta scores: opt: 266 z-score: 322.5 E(): 1.7e-10%3B 39.3%25 identity in 145 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and match to Prosite entry PS00893 mutT domain signature. High content in alanine and leucine amino acid residues gene gene4319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4272 SCO4273 SCO4273 SCD95A.06c SCD95A.06c 4688500 4689921 - metallopeptidase SCD95A.06c%2C possible metallopeptidase%2C len: 473 aa%3B similar to TR:Q9X7P2 (EMBL:AL049587) Streptomyces coelicolor metallopeptidase SC5F2A.19c%2C 506 aa%3B fasta scores: opt: 1253 z-score: 1353.9 E(): 0%3B 42.6%25 identity in 479 aa overlap and to N-terminal domain of SW:AMPN_LACHE (EMBL:U08224) Lactobacillus helveticus aminopeptidase N (EC 3.4.11.2)%2C PepN%2C 844 aa%3B fasta scores: opt: 310 z-score: 333.8 E(): 3.9e-11%3B 27.9%25 identity in 451 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1%2C Peptidase family M1 and matches to Prosite entries PS00013 Prokaryotic membrane lipoprotein lipid attachment site (correctly situated) and PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Contains also a possible N-terminal region signal peptide sequence gene gene4320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4273 SCO4274 SCO4274 SCD95A.07c SCD95A.07c 4690003 4690572 - hypothetical protein SCD95A.07c%2C possible hypothetical protein%2C len: 189 aa%3B similar to TR:CAA74718 (EMBL:Y14336) Streptomyces reticuli extracellular protein containing predicted 35 aa signal peptide precursor%2C 188 aa%3B fasta scores: opt: 773 z-score: 786.2 E(): 0%3B 66.3%25 identity in 187 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4274 SCO4275 SCO4275 SCD95A.08 SCD95A.08 4690823 4692109 + histidine autokinase SCD95A.08%2C probable histidine autokinase%2C len: 428 aa%3B highly similar to TR:CAA74719 (EMBL:Y14336) Streptomyces reticuli histidine autokinase SenS%2C 398 aa%3B fasta scores: opt: 1703 z-score: 1743.6 E(): 0%3B 68.7%25 identity in 396 aa overlap. Contains possible hydrophobic membrane spanning regions in N-terminal domain gene gene4322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4275 SCO4276 SCO4276 SCD95A.09 SCD95A.09 4692106 4692777 + response regulatory protein SCD95A.09%2C probable respose regulatory protein%2C len: 223 aa%3B highly similar to TR:CAA74720 (EMBL:Y14336) Streptomyces reticuli respose regulatory protein SenR%2C 217 aa%3B fasta scores: opt: 1066 z-score: 1252.4 E(): 0%3B 80.4%25 identity in 219 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains also possible helix-turn-helix motif at residues 177..198 (+4.22 SD) gene gene4323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4276 SCO4277 SCO4277 SCD95A.10c SCD95A.10c 4692883 4693458 - tellurium resistance protein SCD95A.10c%2C possible tellurium resistance protein%2C len: 191 aa%3B highly similar to many tellurium resistance related proteins%2C e.g. SW:TERE_SERMA (EMBL:L38824) Serratia marcescens tellurium resistance protein TerE%2C 191 aa%3B fasta scores: opt: 864 z-score: 1027.3 E(): 0%3B 65.4%25 identity in 191 aa overlap and to TR:CAB62770 (EMBL:AL133424) Streptomyces coelicolor SCF56.25 tellurium resistance protein TerD (fragment)%2C 185 aa%3B fasta scores: opt: 950 z-score: 1104.7 E(): 0%3B 75.0%25 identity in 184 aa overlap gene gene4324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4277 SCO4278 SCO4278 SCD95A.11 SCD95A.11 4693616 4694053 + peptidyl-tRNA hydrolase domain-containing protein SCD95A.11%2C hypothetical protein%2C len: 145 aa%3B similar to SW:YAEJ_ECOLI (EMBL:L38619) Escherichia coli hypothetical 15.6 kD protein in MesJ-CutF intergenic region (ORF140) YaeJ%2C 140 aa%3B fasta scores: opt: 338 z-score: 405.8 E(): 3.8e-15%3B 45.7%25 identity in 138 aa overlap. Contains Pfam match to entry PF00472 RF-1%2C Peptidyl-tRNA hydrolase domain and match to Prosite entry PS00745 Prokaryotic-type class I peptide chain release factors signature gene gene4325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4278 SCO4279 SCO4279 SCD95A.12c SCD95A.12c 4694071 4694541 - acetyltransferase SCD95A.12c%2C possible acetyltransferase%2C len: 156 aa%3B similar to TR:AAF22297 (EMBL:AF185569) Rattus norvegicus N-acetyltransferase camello 2%2C Cml2%2C 221 aa%3B fasta scores: opt: 125 z-score: 168.1 E(): 0.067 23.6%25 identity in 123 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene4326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4279 SCO4280 SCO4280 SCD95A.13c SCD95A.13c 4694592 4695200 - reductase SCD95A.13c%2C probable reductase%2C len: 202 aa%3B similar to SW:DIM6_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhidin polyketide dimerase ActVB%2C 177 aa%3B fasta scores: opt: 256 z-score: 298.4 E(): 3.7e-09%3B 37.3%25 identity in 166 aa overlap. Contains Pfam match to entry PF01613 Flavin_Reduct%2C Flavin reductase like domain gene gene4327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4280 SCO4281 SCO4281 SCD95A.14 SCD95A.14 4695536 4697197 + hypothetical protein SCD95A.14%2C hypothetical protein%2C len: 553 aa%3B similar to TR:AAF10046 (EMBL:AE001906) Deinococcus radiodurans sensory Box/GgdEF family protein%2C 805 aa%3B fasta scores: opt: 280 z-score: 304.9 E(): 1.6e-09%3B 28.6%25 identity in 364 aa overlap. Contains Pfam match to entry PF01590 GAF%2C GAF domain%2C PF00989 PAS%2C PAS domain%2C PF00785 PAC%2C PAC motif and PF00990 DUF9%2C Domain of unknown function. Contains also possible coiled-coil region at aprox. residues 197..214. High content in alanine and arginine amino acid residues gene gene4328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4281 SCO4282 SCO4282 SCD95A.15 SCD95A.15 4697318 4698292 + dimeric protein SCD95A.15%2C hypothetical dimeric protein%2C len: 324 aa. Contains match to Prosite entry PS00038 Myc-type%2C 'helix-loop-helix' dimerization domain signature and possible hydrophobic region in the same position. High content in alanine and glycine amino acid residues. Contains possible hydrophobic membrane spanning region gene gene4329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4282 SCO4283 SCO4283 SCD95A.16c SCD95A.16c 4698343 4699275 - sugar kinase SCD95A.16c%2C probable sugar kinase%2C len: 310 aa%3B similar to SW:LACC_LACLA (EMBL:M60447) Lactococcus lactis tagatose-6-phosphate kinase (EC 2.7.1.144) (phosphotagatokinase) LacC%2C 310 aa%3B fasta scores: opt: 559 z-score: 579.1 E(): 8.5e-25%3B 35.9%25 identity in 304 aa overlap. Contains Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase and match to Prosite entry PS00583 pfkB family of carbohydrate kinases signature 1 and PS00584 pfkB family of carbohydrate kinases signature 2 gene gene4330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4283 SCO4284 SCO4284 SCD95A.17c SCD95A.17c 4699398 4700543 - N-acetylglucosamine-6-phosphate deacetylase SCD95A.17c%2C probable N-acetylglucosamine-6-phosphate deacetylase%2C len: 381 aa%3B similar to SW:NAGA_BACSU (EMBL:AF017113) Bacillus subtilis N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) NagA%2C 396 aa%3B fasta scores: opt: 656 z-score: 741.7 E(): 0%3B 34.5%25 identity in 386 aa overlap gene gene4331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4284 SCO4285 SCO4285 SCD95A.18c SCD95A.18c 4700543 4701523 - sugar kinase SCD95A.18%2C possible sugar kinase%2C len: 326 aa%3B similar to TR:CAB60179 (EMBL:AL132824) Streptomyces coelicolor sugar kinase SCAH10.25%2C 382 aa%3B fasta scores: opt: 449 z-score: 453.3 E(): 8.7e-18%3B 37.2%25 identity in 301 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and 5x degenerate repeat: (S/A)AP gene gene4332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4285 SCO4286 SCO4286 SCD95A.19 SCD95A.19 4701671 4702936 + solute-binding protein SCD95A.19%2C possible solute-binding protein ( hypothetical protein)%2C len: 421 aa%3B similar to TR:P72397 (EMBL:Y07706) Streptomyces coelicolor maltose-binding protein MalE%2C 423 aa%3B fasta scores: opt: 348 z-score: 387.3 E(): 4.1e-14%3B 25.9%25 identity in 433 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS01037 Bacterial extracellular solute-binding proteins%2C family 1 signature. Contains also possible N-terminal signal peptide sequence gene gene4333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4286 SCO4287 SCO4287 SCD95A.20 SCD95A.20 4702952 4703206 + hypothetical protein SCD95A.20%2C hypothetical protein%2C len: 84 aa%3B similar to TR:P96276 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 11.7 kD protein MTCY22G10.27%2C 102 aa%3B fasta scores: opt: 244 z-score: 340.2 E(): 1.7e-11%3B 54.2%25 identity in 72 aa overlap gene gene4334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4287 SCO4288 SCO4288 SCD95A.21 SCD95A.21 4703578 4704450 + phosphatase SCD95A.21%2C possible phosphatase%2C len: 290 aa%3B similar to TR:O27788 (EMBL:AE000931) Methanobacterium thermoautotrophicum trehalose-6-phosphate phophatase related protein MTH1760%2C 264 aa%3B fasta scores: opt: 197 z-score: 223.2 E(): 5.7e-05%3B 28.3%25 identity in 258 aa overlap gene gene4335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4288 SCO4289 SCO4289 SCD95A.22 SCD95A.22 4704590 4705072 + hypothetical protein SCD95A.22%2C possible hypothetical protein%2C len: 160 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4289 SCO4290 SCO4290 SCD95A.23c SCD95A.23c 4705079 4706467 - trehalose-phosphate synthase SCD95A.23c%2C possible trehalose-phosphate synthase%2C len: 462 aa%3B similar to SW:OTSA_ECOLI (EMBL:X69160) Escherichia coli alpha%2Calpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15) OtsA%2C 473 aa%3B fasta scores: opt: 511 z-score: 588.8 E(): 2.5e-25%3B 30.6%25 identity in 431 aa overlap. Contains Pfam match to entry PF00982 TrehaloseP_syn%2C Trehalose-6-phosphate synthase domain gene gene4337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4290 SCO4291 SCO4291 SCD95A.24 SCD95A.24 4706614 4707315 + hypothetical protein SCD95A.24%2C possible hypothetical protein%2C len: 233 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. Contains also a conserved repeat: 4x TP gene gene4338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4291 SCO4292 SCO4292 SCD95A.25c SCD95A.25c 4707339 4708283 - glucosyl-3-phosphoglycerate synthase SCD95A.25c%2C hypothetical protein%2C len: 314 aa%3B similar to TR:Q49955 (EMBL:U15180) Mycobacterium leprae U1756L%2C 318 aa%3B fasta scores: opt: 792 z-score: 901.0 E(): 0%3B 48.0%25 identity in 304 aa overlap gene gene4339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4292 SCO4293 SCO4293 SCD95A.26 SCD95A.26 4708607 4709893 + threonine synthase catalyzes the formation of L-threonine from O-phospho-L-homoserine gene gene4340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4293 SCO4294 SCO4294 SCD95A.27 SCD95A.27 4709890 4710165 + hypothetical protein SCD95A.27%2C hypothetical protein%2C len: 91 aa%3B similar to SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical 9.6 kD protein MTCY130.20%2C 93 aa%3B fasta scores: opt: 369 z-score: 480.3 E(): 2.7e-19%3B 63.4%25 identity in 93 aa overlap%2C to TR:CAB50992 (EMBL:AL096852) Streptomyces coelicolor hypothetical protein SCE19A.11c%2C 92 aa%3B fasta scores: opt: 332 z-score: 416.4 E(): 1.2e-17%3B 54.9%25 identity in 91 aa overlap and highly similar to TR:Q9EUR9 (EMBL:AJ250537) Streptomyces hygroscopicus hypothetical protein%2C 92 aa%3B fasta scores: opt: 496 Z-score: 626.4 E(): 2.9e-27%3B 83.516%25 identity in 91 aa overlap gene gene4341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4294 SCO4295 SCO4295 SCD95A.28 SCD95A.28 4710584 4710787 + cold shock protein SCD95A.28%2C scoF4%2C cold shock protein%2C len: 67 aa%3B highly similar to TR:AAD49327 (EMBL:AF162937) Streptomyces coelicolor A3(2) cold shock protein F40%2C 67 aa%3B fasta scores: opt: 317 z-score: 454.8 E(): 7.2e-18%3B 70.3%25 identity in 64 aa overlap. Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain and match to Prosite entry PS00352 'Cold-shock' DNA-binding domain signature gene gene4342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4295 SCO4296 SCO4296 groEL groEL 4711115 4712740 + chaperonin GroEL 60 kDa chaperone family%3B promotes refolding of misfolded polypeptides especially under stressful conditions%3B forms two stacked rings of heptamers to form a barrel-shaped 14mer%3B ends can be capped by GroES%3B misfolded proteins enter the barrel where they are refolded when GroES binds%3B many bacteria have multiple copies of the groEL gene which are active under different environmental conditions%3B the B.japonicum protein in this cluster is expressed constitutively%3B in Rhodobacter%2C Corynebacterium and Rhizobium this protein is essential for growth gene gene4343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4296 SCO4297 SCO4297 SCD95A.30 SCD95A.30 4712991 4714121 + oxidoreductase SCD95A.30%2C probable oxidoreduxtase%2C len: 376 aa%3B similar to SW:NADO_THEBR (EMBL:X67220) Thermoanaerobacter brockii NADH oxidase%2C 651 aa%3B fasta scores: opt: 498 z-score: 552.0 E(): 2.8e-23%3B 33.6%25 identity in 354 aa overlap. Contains Pfam match to entry PF00724 oxidored_FMN%2C FMN oxidoreductase gene gene4344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4297 SCO4298 SCO4298 SCD95A.31 SCD95A.31 4714155 4715696 + carboxylesterase SCD95A.31%2C probable carboxylesterase%2C len: 513 aa%3B similar to TR:Q9Z545 (EMBL:AL035212) Streptomyces coelicolor carboxylesterase SC9B2.14%2C 502 aa%3B fasta scores: opt: 1093 z-score: 1041.3 E(): 0%3B 44.6%25 identity in 511 aa overlap and to SW:PNBA_BACSU (EMBL:U06089) Bacillus subtilis para-nitrobenzyl esterase (EC 3.1.1.-) PnbA%2C 489 aa%3B fasta scores: opt: 823 z-score: 786.2 E(): 0%3B 38.1%25 identity in 501 aa overlap. Contains Pfam match to entry PF00135 COesterase%2C Carboxylesterases and match to Prosite entry PS00122 Carboxylesterases type-B serine active site gene gene4345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4298 SCO4299 SCO4299 SCD95A.32 SCD95A.32 4715693 4716040 + hypothetical protein SCD95A.32%2C possible integral membrane protein%2C len: 115 aa. Contains possible hydrophobic membrane spanning regions. High content in glycine amino acid residues gene gene4346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4299 SCO4300 SCO4300 SCD95A.33c SCD95A.33c 4716003 4716272 - hypothetical protein SCD95A.33c%2C hypothetical protein%2C len: 89 aa%3B similar to TR:CAB69735 (EMBL:AL137166) Streptomyces coelicolor hypothetical 10.2 kD protein SCC121.17%2C 96 aa%3B fasta scores: opt: 251 z-score: 338.4 E(): 2.2e-11%3B 51.1%25 identity in 94 aa overlap gene gene4347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4300 SCO4301 SCO4301 SCD95A.34c SCD95A.34c 4716256 4717095 - DNA-binding protein SCD95A.34c%2C possible DNA-binding protein%2C len: 279 aa%3B similar to various S. coelicolor hypothetical proteins%2C e.g. TR:CAB69734 (EMBL:AL137166) Streptomyces coelicolor hypothetical 30.4 kD protein SCC121.16%2C 277 aa%3B fasta scores: opt: 731 z-score: 897.3 E(): 0%3B 45.2%25 identity in 259 aa overlap and to TR:CAB88448 (EMBL:AL353815) Streptomyces coelicolor DNA-binding protein SCD6.19%2C 295 aa%3B fasta scores: opt: 388 z-score: 478.8 E(): 3.3e-19%3B 34.3%25 identity in 286 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation and a possible helix-turn-helix motif at residues 30..51 (+3.39 SD) gene gene4348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4301 SCO4302 SCO4302 SCD95A.35 SCD95A.35 4717214 4717603 + hypothetical protein SCD95A.35%2C possible hypothetical protein%2C len: 129 aa%3B N-terminal domain similar to TR:CAB69733 (EMBL:AL137166) Streptomyces coelicolor hypothetical 7.1 kD protein SCC121.15c%2C 68 aa%3B fasta scores: opt: 202 z-score: 262.4 E(): 3.7e-07%3B 52.5%25 identity in 59 aa overlap and C-terminal domain similar to TR:CAB69732 (EMBL:AL137166) Streptomyces coelicolor hypothetical 7.8 kD protein SCC121.14c%2C 73 aa%3B fasta scores: opt: 198 z-score: 257.2 E(): 7.3e-07%3B 51.6%25 identity in 64 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4302 SCO4303 SCO4303 SCD95A.36c SCD95A.36c 4717614 4718222 - transcriptional regulator SCD95A.36c%2C possible transcriptional regulator%2C len: 202 aa%3B similar to SW:YCFQ_ECOLI (EMBL:AE000211) Escherichia coli hypothetical transcriptional regulator in Ndh-Mfd intergenic region YcfQ%2C 210 aa%3B fasta scores: opt: 401 z-score: 492.0 E(): 6.1e-20%3B 37.3%25 identity in 201 aa overlap gene gene4350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4303 SCO4304 SCO4304 SCD95A.37 SCD95A.37 4718317 4719066 + oxidoreductase SCD95A.37%2C probable oxidoreductase%2C len: 249 aa%3B similar to TR:CAB71826 (EMBL:AL138662) Streptomyces coelicolor dehydrogenase/reductase SC8E4A.21c%2C 245 aa%3B fasta scores: opt: 757 z-score: 795.6 E(): 0%3B 50.0%25 identity in 250 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene4351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4304 SCO4305 SCO4305 SCD95A.38c SCD95A.38c 4719080 4719673 - hypothetical protein SCD95A.38c%2C hypothetical protein%2C len: 197 aa%3B similar to TR:Q9X9V5 (EMBL:AL096743) Streptomyces coelicolor hypothetical 21.2 kD protein SCI7.35c%2C 197 aa%3B fasta scores: opt: 216 z-score: 272.7 E(): 9.9e-08%3B 35.2%25 identity in 199 aa overlap gene gene4352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4305 SCO4306 SCO4306 SCD95A.39c SCD95A.39c 4719675 4720244 - hypothetical protein SCD95A.39c%2C unknown%2C len: 189 aa gene gene4353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4306 SCO4307 SCO4307 murQ murQ 4720312 4721247 - N-acetylmuramic acid-6-phosphate etherase catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate%3B involved in MurNAc dissimilation pathway gene gene4354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4307 SCO4308 SCO4308 SCD95A.41c SCD95A.41c 4721346 4722308 - transcriptional regulator SCD95A.41c%2C possible transcriptional regulator%2C len: 320 aa%3B similar to TR:CAB84834 (EMBL:AL162756) Neisseria meningitidis transcriptional regulator NMA1605%2C 282 aa%3B fasta scores: opt: 476 z-score: 465.7 E(): 1.8e-18%3B 33.5%25 identity in 281 aa overlap and to SW:HEXR_ECOLI (EMBL:AE000279) Escherichia coli hex regulon repressor HexR%2C 289 aa%3B fasta scores: opt: 337 z-score: 333.6 E(): 4.1e-11%3B 26.6%25 identity in 274 aa overlap. Contains Pfam matches to entries PF01418 HTH_6%2C Helix-turn-helix domain%2C rpiR family and PF01380 SIS%2C SIS domain gene gene4355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4308 SCO4309 SCO4309 SCD95A.42 SCD95A.42 4722391 4722771 + hypothetical protein SCD95A.42%2C unknown%2C len: 126 aa gene gene4356 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4309 SCO4310 SCO4310 SCD95A.43 SCD95A.43 4722782 4723078 + hypothetical protein SCD95A.43%2C hypothetical protein%2C len: 98 aa%3B highly similar to TR:P96070 (EMBL:U09991) Streptomyces violaceus ISP5230 chloramphenicol resistance protein (CMLV) and chloramphenicol phosphotransferase genes%2C complete CDS (fragment)%2C 89 aa%3B fasta scores: opt: 450 z-score: 589.5 E(): 2.3e-25%3B 74.1%25 identity in 85 aa overlap gene gene4357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4310 SCO4311 SCO4311 SCD95A.44c SCD95A.44c 4723060 4724157 - hypothetical protein SCD95A.44c%2C hypothetical protein%2C len: 365 aa%3B similar to TR:O31648 (EMBL:Z99110) Bacillus subtilis YjdG protein%2C 168 aa%3B fasta scores: opt: 214 z-score: 251.8 E(): 1.5e-06%3B 30.5%25 identity in 154 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene4358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4311 SCO4312 SCO4312 SCD95A.45c SCD95A.45c 4724168 4724956 - hypothetical protein SCD95A.45c%2C hypothetical protein%2C len: 262 aa%3B similar to TR:Q9I3L7 (EMBL:AE004578) Pseudomonas aeruginosa hypothetical protein PA1495%2C 208 aa%3B fasta scores: opt: 479 Z-score: 529.6 E(): 7.2e-22%3B 44.330%25 identity in 194 aa overlap. High content in alanine amino acid residues. Contains also a TTA leucine codon%2C possible target for bldA regulation gene gene4359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4312 SCO4313 SCO4313 SCD95A.46 SCD95A.46 4724955 4725605 + regulatory protein SCD95A.46%2C possible regulatory protein%2C len: 216 aa%3B similar to TR:CAB56658 (EMBL:AL121596) Streptomyces coelicolor tetR family transcriptional regulator SCF51A.06%2C 177 aa%3B fasta scores: opt: 164 z-score: 202.9 E(): 0.00077%3B 32.0%25 identity in 103 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 37..58 (+5.35 SD) gene gene4360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4313 SCO4314 SCO4314 SCD95A.47 SCD95A.47 4725616 4726299 + hypothetical protein SCD95A.47%2C hypothetical protein%2C len: 227 aa%3B similar to TR:O53480 (EMBL:AL021899) Mycobacterium tuberculosis hypothetical 23.2 kD protein MTV018.23%2C 213 aa%3B fasta scores: opt: 178 z-score: 217.9 E(): 0.00011%3B 29.0%25 identity in 200 aa overlap gene gene4361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4314 SCO4315 SCO4315 SCD95A.48 SCD95A.48 4726384 4727073 + homeostasis protein SCD95A.48%2C possible homeostasis protein%2C len: 229 aa%3B similar to SW:CUTC_ECOLI (EMBL:L38618) Escherichia coli copper homeostasis protein CutC%2C 248 aa%3B fasta scores: opt: 302 z-score: 336.1 E(): 2.9e-11%3B 31.3%25 identity in 208 aa overlap gene gene4362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4315 SCO4316 SCO4316 SCD95A.49c SCD95A.49c 4727234 4729279 - ATP/GTP binding protein SCD95A.49c%2C possible ATP/GTP binding protein%2C len: 681 aa%3B similar to TR:CAB72415 (EMBL:AL138978) Streptomyces coelicolor hypothetical 82.6 kD protein SC6A11.15%2C 755 aa%3B fasta scores: opt: 683 z-score: 757.1 E(): 0%3B 33.5%25 identity in 767 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4316 SCO4317 SCO4317 SCD95A.50 SCD95A.50 4729548 4729769 + hypothetical protein SCD95A.50%2C unknown%2C len: 73 aa gene gene4364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4317 SCO4318 SCO4318 SCD95A.51c SCD95A.51c 4729773 4731411 - gene gene4365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4318 SCO4319 SCO4319 SCD12A.02c SCD12A.02c 4731490 4731672 - hypothetical protein SCD12A.02c%2C possible integral membrane protein%2C len: 60 aa. Contains possible hydrophobic membrane spanning regions. High content in proline amino acid residues gene gene4366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4319 SCO4320 SCO4320 SCD12A.03c SCD12A.03c 4731774 4731893 - hypothetical protein SCD12A.03c%2C membrane protein%2C len: 39 aa%3B doubtful CDS%2C TBparse predicted. Contains possible hydrophobic membrane spanning regions gene gene4367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4320 SCO4321 SCO4321 SCD12A.04c SCD12A.04c 4732070 4734673 - hypothetical protein SCD12A.04c%2C hypothetical protein%2C len: 867 aa%3B similar to TR:O53874 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 79.7 kD protein (fragment) MTV043.55c aa%3B fasta scores: opt: 651 z-score: 618.2 E(): 5.7e-27%3B 36.1%25 identity in 886 aa overlap gene gene4368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4321 SCO4322 SCO4322 SCD12A.05 SCD12A.05 4734723 4735823 + hypothetical protein SCD12A.05%2C possible integral membrane protein%2C len: 366 aa. Contains possible hydrophobic membrane spanning regions at C-terminal domain. High content in alanine%2C arginine and glycine amino acid residues gene gene4369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4322 SCO4323 SCO4323 SCD12A.06 SCD12A.06 4736376 4737038 + hydrolase SCD12A.06%2C possible hydrolase%2C len: 220 aa%3B similar to TR:O86530 (EMBL:AL031124) Streptomyces coelicolor hydrolase SC1C2.30%2C 244 aa%3B fasta scores: opt: 128 z-score: 155.4 E(): 0.34%3B 32.9%25 identity in 167 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene4370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4323 SCO4324 SCO4324 SCD12A.07c SCD12A.07c 4736987 4737265 - hypothetical protein SCD12A.07c%2C possible integral membrane protein%2C len: 92 aa. Contains possible hydrophobic membrane spanning regions. High content in alanine amino acid residues gene gene4371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4324 SCO4325 SCO4325 cspB cspB 4737441 4737824 + cold shock protein B SCD12A.08%2C cspB%2C cold shock protein B%2C len: 127 aa%3B highly similar to TR:O53883 (EMBL:AL022004) Mycobacterium tuberculosis cold shock protein B%2C CspB%2C 135 aa%3B fasta scores: opt: 471 z-score: 565.4 E(): 5e-24%3B 51.5%25 identity in 134 aa overlap and to SW:CSPC_BACCE (EMBL:X93041) Bacillus cereus cold shock-like protein CspC%2C 65 aa%3B fasta scores: opt: 245 z-score: 306.7 E(): 1.3e-09%3B 57.1%25 identity in 63 aa overlap%2C although double in length. Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain gene gene4372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4325 SCO4326 SCO4326 SCD12A.09c SCD12A.09c 4737844 4738692 - 1%2C4-dihydroxy-6-naphtoate synthase SCD12A.09c%2C conserved hypothetical protein%2C len: 282 aa%3B similar to TR:AAF10587 (EMBL:AE001953) Deinococcus radiodurans conserved hypothetical protein DR1011%2C 301 aa%3B fasta scores: opt: 762 z-score: 923.2 E(): 0%3B 47.6%25 identity in 275 aa overlap gene gene4373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4326 SCO4327 SCO4327 SCD12A.10c SCD12A.10c 4738682 4739311 - hypothetical protein SCD12A.10c%2C hypothetical protein%2C len: 209 aa%3B similar to TR:AAF11232 (EMBL:AE002009) Deinococcus radiodurans hypothetical 19.1 kD protein DR1664%2C 193 aa%3B fasta scores: opt: 444 z-score: 477.4 E(): 4e-19%3B 47.8%25 identity in 182 aa overlap gene gene4374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4327 SCO4328 SCO4328 SCD12A.11c SCD12A.11c 4739405 4739869 - lipoprotein SCD12A.11c%2C possible lipoprotein%2C len: 154 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4328 SCO4329 SCO4329 SCD12A.12c SCD12A.12c 4739973 4741364 - hypothetical protein SCD12A.12c%2C possible integral membrane protein%2C len: 463 aa%3B similar to TR:Q9X8T4 (EMBL:AL049826) Streptomyces coelicolor membrane protein SCH24.20c%2C 425 aa%3B fasta scores: opt: 305 z-score: 344.1 E(): 1.1e-11%3B 28.7%25 identity in 411 aa overlap. Contains possible hidrophobic membrane spanning regions gene gene4376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4329 SCO4330 SCO4330 SCD12A.13 SCD12A.13 4741698 4742624 + hypothetical protein SCD12A.13%2C hypothetical protein%2C len: 308 aa%3B similar to TR:O33058 (EMBL:Z99494) Mycobacterium leprae hypothetical 28.2 kD protein MLCB57.28%2C 269 aa%3B fasta scores: opt: 432 z-score: 470.7 E(): 9.4e-19%3B 43.3%25 identity in 270 aa overlap gene gene4377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4330 SCO4331 SCO4331 SCD12A.14 SCD12A.14 4742777 4745905 + hypothetical protein SCD12A.14%2C hypothetical protein%2C len: 1042 aa%3B similar to TR:CAB61192 (EMBL:AL132973) Streptomyces coelicolor hypothetical 93.0 kD protein SCF91.35%2C 884 aa%3B fasta scores: opt: 160 z-score: 164.2 E(): 0.11%3B 26.0%25 identity in 666 aa overlap gene gene4378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4331 SCO4332 SCO4332 SCD12A.15c SCD12A.15c 4746028 4748436 - integral membrane ATPase SCD12A.15c%2C possible integral membrane ATPase%2C len: 802 aa%3B similar to TR:Q9Z4W5 (EMBL:AL035654) Streptomyces coelicolor integral membrane ATPase SCE8.09%2C 796 aa%3B fasta scores: opt: 3320 z-score: 3591.6 E(): 0%3B 67.0%25 identity in 796 aa overlap and to TR:O93862 (EMBL:AF043332) Aspergillus nidulans plasma membrane H(+)ATPase PmaA%2C 990 aa%3B fasta scores: opt: 504 z-score: 543.3 E(): 8.4e-23%3B 25.4%25 identity in 808 aa overlap. Contains 2x Pfam match to entry PF00122 E1-E2_ATPase%2C E1-E2 ATPase and match to Prosite entry PS00154 E1-E2 ATPases phosphorylation site. Contains also possible hydrophobic membrane spanning regions gene gene4379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4332 SCO4333 SCO4333 SCD12A.16c SCD12A.16c 4748536 4748796 - hypothetical protein SCD12A.16c%2C possible integral membrane protein%2C len: 86 aa. Contains possible hydrophobic membrane spanning regions gene gene4380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4333 SCO4334 SCO4334 SCD12A.17 SCD12A.17 4749000 4750457 + hypothetical protein SCD12A.17%2C possible integral membrane protein%2C len: 485 aa%3B similar to TR:Q9ZBN6 (EMBL:AL034492) Streptomyces coelciolor hypothetical 50.0 kD protein SC6C5.09%2C 485 aa%3B fasta scores: opt: 1532 z-score: 1657.3 E(): 0%3B 51.1%25 identity in 456 aa overlap. Contains Pfam match to entry PF00860 xan_ur_permease%2C Xanthine/uracil permeases family and match to Prosite entry PS00012 Phosphopantetheine attachment site. Contains also possible hydrophobic membrane spanning regions gene gene4381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4334 SCO4335 SCO4335 SCD12A.18c SCD12A.18c 4750489 4750677 - hypothetical protein SCD12A.18c%2C unknown%2C len: 62 aa gene gene4382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4335 SCO4336 SCO4336 SCD12A.19 SCD12A.19 4750828 4751265 + marR-family protein SCD12A.19%2C possible marR-family protein%2C len: 145 aa%3B similar to TR:CAB56677 (EMBL:AL121596) Streptomyces coelicolor marR-family protein SCF51A.25%2C 148 aa%3B fasta scores: opt: 227 z-score: 290.1 E(): 1.1e-08%3B 38.6%25 identity in 132 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene4383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4336 SCO4337 SCO4337 SCD12A.20 SCD12A.20 4751293 4752672 + integral membrane efflux protein SCD12A.20%2C possible integral membrane efflux protein%2C len: 459 aa%3B similar to TR:Q9X863 (EMBL:AL049661) Streptomyces coelicolor integral membrane efflux protein SCE134.08%2C 500 aa%3B fasta scores: opt: 2083 z-score: 2154.5 E(): 0%3B 71.1%25 identity in 450 aa overlap and to TR:Q50396 (EMBL:U46844) Mycobacterium smegmatis ethambutanol resistance region EmbC%2C 412 aa%3B fasta scores: opt: 844 z-score: 878.0 E(): 0%3B 38.8%25 identity in 399 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4337 SCO4338 SCO4338 SCD12A.21 SCD12A.21 4752722 4753294 + 2'-5' RNA ligase SCD12A.21%2C hypothetical protein%2C len: 190 aa%3B similar to TR:Q45633 (EMBL:L13418) Bacillus stearothermophilus maltose permease MalA%2C 314 aa%3B fasta scores: opt: 207 z-score: 246.2 E(): 3e-06%3B 31.3%25 identity in 160 aa overlap. Contains match to Prosite entry PS00216 Sugar transport proteins signature 1 gene gene4385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4338 SCO4339 SCO4339 SCD12A.22c SCD12A.22c 4753436 4754290 - reductase SCD12A.22c%2C possible reductase%2C len: 284 aa%3B similar to SW:STCV_EMENI (EMBL:U34740) Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV%2C 387 aa%3B fasta scores: opt: 401 z-score: 462.6 E(): 2.6e-18%3B 32.0%25 identity in 284 aa overlap and to TR:O33936 (EMBL:U77454) Saccharopolyspora erythraea EryBII%2C 333 aa%3B fasta scores: opt: 970 z-score: 1111.9 E(): 0%3B 53.7%25 identity in 287 aa overlap gene gene4386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4339 SCO4340 SCO4340 SCD12A.23 SCD12A.23 4754366 4756015 + integrase SCD12A.23%2C possible integrase%2C len: 549 aa%3B similar to TR:CAB75384 (EMBL:AL139298) Streptomyces coelicolor integrase SCC88.14%2C 518 aa%3B fasta scores: opt: 232 z-score: 262.7 E(): 3.6e-07%3B 26.5%25 identity in 548 aa overlap gene gene4387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4340 SCO4341 SCO4341 SCD12A.24 SCD12A.24 4756150 4756464 + hypothetical protein SCD12A.24%2C unknown%2C len: 104 aa gene gene4388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4341 SCO4342 SCO4342 SCD12A.25 SCD12A.25 4756861 4757403 + hypothetical protein SCD12A.25%2C hypothetical protein%2C len: 180 aa%3B similar to TR:Q9X9V2 (EMBL:Y18817) Streptomyces coelicolor A3(2) mini-circle protein ORF7%2C 165 aa%3B fasta scores: opt: 166 z-score: 222.3 E(): 6.4e-05%3B 35.3%25 identity in 167 aa overlap and to SW:YM2_STRCO (EMBL:X15942) Streptomyces coelicolor mini-circle hypothetical 13.3 kD protein%2C 122 aa%3B fasta scores: opt: 165 z-score: 223.0 E(): 5.8e-05%3B 33.6%25 identity in 125 aa overlap gene gene4389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4342 SCO4343 SCO4343 SCD12A.26c SCD12A.26c 4757436 4757633 - hypothetical protein SCD12A.26c%2C unknown%2C len: 65 aa%3B similar to C-terminal part of TR:Q52559 (EMBL:L48985) Pseudomonas syringae transposase TnpA%2C 343 aa%3B fasta scores: opt: 87 z-score: 136.6 E(): 3.8%3B 34.0%25 identity in 47 aa overlap gene gene4390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4343 SCO4344 SCO4344 SCD12A.27c SCD12A.27c 4757715 4758560 - transposase SCD12A.27c%2C possible transposase%2C len: 281 aa%3B similar to TR:BAA85092 (EMBL:AB029445) Shigella sonnei transposase TPase%2C 343 aa%3B fasta scores: opt: 181 z-score: 222.1 E(): 6.5e-05%3B 21.9%25 identity in 274 aa overlap gene gene4391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4344 SCO4345 SCO4345 SCD12A.28 SCD12A.28 4759042 4759623 + hypothetical protein SCD12A.28%2C unknown%2C len: 193 aa gene gene4392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4345 SCO4346 SCO4346 SCD12A.29c SCD12A.29c 4759891 4761000 - hypothetical protein SCD19.01c%2C unknown(fragment)%2C len: >119 aa. Contains two TTA leucine codons%2C possible targets for bldA regulation~SCD12A.29c%2C unknown (fragment)%2C len: > 282 aa gene gene4393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4346 SCO4347 SCO4347 SCD19.02c SCD19.02c 4761245 4761673 - hypothetical protein SCD19.02c%2C unknown%2C len: 142 aa. High content in alanine%2C arginine and leucine amino acid residues gene gene4394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4347 SCO4348 SCO4348 SCD19.03c SCD19.03c 4761670 4763841 - hypothetical protein SCD19.03c%2C hypothetical protein%2C len: 723 aa%3B similar to some plasmid derived hypothetical proteins%2C e.g. TR:O85873 (EMBL:AF079317) Sphingomonas aromaticivorans hypothetical 81.3 kDa protein (plasmid pNL1)%2C 741 aa%3B fasta scores: opt: 421 z-score: 478.1 E(): 4e-19%3B 29.7%25 identity in 758 aa overlap gene gene4395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4348 SCO4349 SCO4349 SCD19.04c SCD19.04c 4763838 4765553 - hypothetical protein SCD19.04c%2C hypothetical protein%2C len: 571 aa%3B similar to some plasmid derived hypothetical proteins%2C e.g. TR:O85872 (EMBL:AF079317) Sphingomonas aromaticivorans hypothetical 65.3 kDa protein (plasmid pNL1)%2C 595 aa%3B fasta scores: opt: 344 z-score: 399.6 E(): 9.4e-15%3B 26.7%25 identity in 561 aa overlap. Contains two TTA leucine codons%2C possible targets for bldA regulation gene gene4396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4349 SCO4350 SCO4350 SCD19.05c SCD19.05c 4765553 4766905 - integrase SCD19.05c%2C possible integrase%2C len: 475 aa%3B highly similar to TR:Q9RAJ3 (EMBL:AJ250372) Mycobacterium sp. GP1 integrase IntM%2C 451 aa%3B fasta scores: opt: 2152 z-score: 2497.3 E(): 0%3B 72.8%25 identity in 441 aa overlap gene gene4397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4350 SCO4351 SCO4351 SCD19.06 SCD19.06 4767115 4767627 + DNA invertase SCD19.06%2C probable DNA invertase%2C len: 170 aa%3B similar to SW:DNIV_BPP1 (EMBL:X01828) Bacteriophage P1 DNA-invertase (site-specific recombinase) Cin%2C 186 aa%3B fasta scores: opt: 471 z-score: 560.8 E(): 9.9e-24%3B 48.8%25 identity in 170 aa overlap. Contains Pfam match to entry PF00239 recombinase%2C Site-specific recombinases gene gene4398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4351 SCO4352 SCO4352 SCD19.07 SCD19.07 4767684 4768676 + oxidoreductase SCD19.07%2C probable oxidoreductase%2C len: 330 aa%3B similar to SW:NORA_ASPFL (EMBL:U32377) Aspergillus flavus norsolorinic acid reductase (EC 1.1.1.-) NorA%2C 388 aa%3B fasta scores: opt: 508 z-score: 583.8 E(): 5.2e-25%3B 32.1%25 identity in 330 aa overlap and to TR:CAB93413 (EMBL:AL357524) Streptomyces coelicolor reductase SCD12A.22c%2C 284 aa%3B fasta scores: opt: 1699 z-score: 1942.0 E(): 0%3B 87.3%25 identity in 284 aa overlap. Contains Pfam match to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene4399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4352 SCO4353 SCO4353 SCD19.08c SCD19.08c 4768814 4768972 - hypothetical protein SCD19.08c%2C hypothetical protein%2C len: 52 aa%3B similar to N-terminal domain of TR:Q9S0N9 (EMBL:AB032523) Streptomyces avermitilis DTDP-4-keto-6-deoxy-L-hexose 2%2C3-reductase AveBVIII%2C 347 aa%3B fasta scores: opt: 165 z-score: 253.6 E(): 1.3e-06%3B 51.0%25 identity in 49 aa overlap and to N-terminal domain of Streptomyces coelicolor SCD19.07%2C 330 aa%3B fasta scores: opt: 293 z-score: 403.7 E(): 7.6e-17%3B 88.2%25 identity in 51 aa overlap gene gene4400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4353 SCO4354 SCO4354 SCD19.09c SCD19.09c 4769020 4769703 - hypothetical protein SCD19.09c%2C hypothetical protein%2C len: 227 aa%3B similar to TR:Q9RDD3 (EMBL:AL136503) Streptomyces coelicolor hypothetical 25.0 kDa protein SCC77.25c%2C 224 aa%3B fasta scores: opt: 234 z-score: 297.1 E(): 4.8e-09%3B 30.3%25 identity in 208 aa overlap gene gene4401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4354 SCO4355 SCO4355 SCD19.10 SCD19.10 4769704 4770477 + nucleotidyltransferase SCD19.10%2C probable nucleotidyltransferase%2C len: 257 aa%3B similar to SW:S3AD_STAAU (EMBL:X02588) Staphylococcus aureus streptomycin 3''-adenylyltransferase (EC 2.7.7.47) Spc%2C 260 aa%3B fasta scores: opt: 644 z-score: 760.8 E(): 0%3B 44.5%25 identity in 227 aa overlap. Contains Pfam match to entry PF01909 NTP_transf_2%2C Nucleotidyltransferase domain gene gene4402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4355 SCO4356 SCO4356 SCD19.11c SCD19.11c 4770450 4771139 - hypothetical protein SCD19.11c%2C unknown%2C len: 229 aa gene gene4403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4356 SCO4357 SCO4357 SCD19.12 SCD19.12 4771195 4772241 + hypothetical protein SCD19.12%2C possible integral membrane protein%2C len: 348 aa. Contains possible hydrophobic membrane spanning regions gene gene4404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4357 SCO4358 SCO4358 SCD19.13c SCD19.13c 4772215 4773021 - TetR family transcriptional regulator SCD19.13c%2C probable tetR family transcriptional regulatory protein%2C len: 268 aa%3B similar to TR:Q9S2B2 (EMBL:AL096849) Streptomyces coelicolor transcriptional regulator SCI11.07c%2C 234 aa%3B fasta scores: opt: 472 z-score: 546.8 E(): 6e-23%3B 40.2%25 identity in 229 aa overlap and to TR:Q53901 (EMBL:M64683) Streptomyces coelicolor ORF1-4 (actII)%2C 259 aa%3B fasta scores: opt: 333 z-score: 387.9 E(): 4.2e-14%3B 32.1%25 identity in 243 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 56..77 (+3.34 SD) gene gene4405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4358 SCO4359 SCO4359 SCD19.14 SCD19.14 4773118 4774128 + ABC transporter ATP-binding protein SCD19.14%2C probable ABC transport system ATP-binding protein%2C len: 336 aa%3B similar to SW:DRRA_STRPE (EMBL:M73758) Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA%2C 330 aa%3B fasta scores: opt: 912 z-score: 964.7 E(): 0%3B 49.5%25 identity in 327 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4359 SCO4360 SCO4360 SCD19.15 SCD19.15 4774125 4774967 + ABC transporter SCD19.15%2C probable ABC transport system integral membrane protein%2C len: 280 aa%3B similar to SW:DRRB_STRPE (EMBL:M73758) Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB%2C 283 aa%3B fasta scores: opt: 413 z-score: 474.0 E(): 6.8e-19%3B 31.6%25 identity in 244 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4360 SCO4361 SCO4361 SCD19.16 SCD19.16 4775082 4775639 + hypothetical protein SCD19.16%2C possible integral membrane protein%2C len: 185 aa. Contains possible hydrophobic membrane spanning regions gene gene4408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4361 SCO4362 SCO4362 SCD19.17 SCD19.17 4775642 4776853 + two component system sensor kinase SCD19.17%2C possible two component system sensor kinase%2C len: 403 aa%3B similar to TR:O70000 (EMBL:AL022374) Streptomyces coelicolor two-component sensor SC5B8.14%2C 384 aa%3B fasta scores: opt: 580 z-score: 600.9 E(): 5.7e-26%3B 36.8%25 identity in 353 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4362 SCO4363 SCO4363 SCD19.18 SCD19.18 4776850 4777530 + two component system response regulator SCD19.18%2C probable two component system response regulator%2C len: 226 aa%3B similar to TR:O70001 (EMBL:AL022374) Streptomyces coelicolor two-component regulator SC5B8.15%2C 229 aa%3B fasta scores: opt: 691 z-score: 751.7 E(): 0%3B 54.4%25 identity in 215 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains possible helix-turn-helix motif at residues 181..202 (+3.68 SD) gene gene4410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4363 SCO4364 SCO4364 SCD19.19 SCD19.19 4777590 4777967 + hypothetical protein SCD19.19%2C unknown%2C len: 125 aa gene gene4411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4364 SCO4365 SCO4365 SCD19.20 SCD19.20 4778003 4778245 + hypothetical protein SCD19.20%2C unknown%2C len: 80 aa gene gene4412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4365 SCO4366 SCO4366 SCD19.21c SCD19.21c 4778229 4779320 - phosphoserine aminotransferase catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate gene gene4413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4366 SCO4367 SCO4367 SCD19.22 SCD19.22 4779458 4782313 + oxidoreductase SCD19.22%2C possible oxidoreductase%2C len: 951 aa%3B N-terminal domain similar to SW:GLCD_ECOLI (EMBL:L43490) Escherichia coli glycolate oxidase subunit GlcD%2C 499 aa%3B fasta scores: opt: 351 z-score: 387.8 E(): 4.3e-14%3B 31.2%25 identity in 497 aa overlap and C-terminal domain similar to SW:GLCF_ECOLI (EMBL:L43490) Escherichia coli glycolate oxidase iron-sulfur subunit GlcF%2C 407 aa%3B blastp scores: Score%3D 113 (39.8 bits)%2C Expect%3D 8.0e-10%2C Sum P(2)%3D 8.0e-10%3B Identities%3D 26/78 (33%25)%2C Positives%3D 39/78 (50%25) and Identities%3D 61/237 (25%25)%2C Positives%3D 91/237 (38%25). Contains Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain and match to Prosite entry PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene4414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4367 SCO4368 SCO4368 SCD19.23c SCD19.23c 4782332 4783492 - lipase SCD19.23c%2C possible lipase (hypothetical protein)%2C len: 386 aa%3B similar to TR:Q9Z360 (EMBL:AL035654) Streptomyces coelicolor lipase SCE8.12c%2C 391 aa%3B fasta scores: opt: 867 z-score: 923.3 E(): 0%3B 44.3%25 identity in 393 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4368 SCO4369 SCO4369 2SCD52.01 2SCD52.01 4783583 4785205 + hypothetical protein 2SCD52.01%2C hypothetical protein (fragment)%2C len: >312 aa%3B similar to N-terminal region of TR:CAB95880 (EMBL:AL359988) Streptomyces coelicolor hypothetical 26.1 kDa protein (fragment) SCD10.01%2C 261 aa%3B fasta scores: opt: 232 z-score: 233.3 E(): 1.7e-05%3B 32.0%25 identity in 225 aa overlap~SCD10.01%2C unknown (fragment)%2C len: >261 aa. High content in glycine and aspartate amino acid residues. Contains 2x Pfam match to entry PF01839 FG-GAP%2C FG-GAP repeat gene gene4416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4369 SCO4370 SCO4370 SCD10.02 SCD10.02 4785438 4786457 + transposase SCD10.02%2C possible transposase%2C len: 339 aa%3B identical to TR:CAB71807 (EMBL:AL138662) Streptomyces coelicolor transposase SC8E4A.02%2C 339 aa gene gene4417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4370 SCO4371 SCO4371 SCD10.03 SCD10.03 4786553 4787116 + hypothetical protein SCD10.03%2C conserved hypothetical protein%2C len: 187 aa%3B similar to TR:CAB93416 (EMBL:AL357524) Streptomyces coelicolor hypothetical 20.0 kD protein SCD12A.25%2C 180 aa%3B fasta scores: opt: 216 z-score: 277.0 E(): 5.9e-08%3B 32.0%25 identity in 178 aa overlap. Contains also a 3x degenerate repeat (T/P)TTE gene gene4418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4371 SCO4372 SCO4372 SCD10.04c SCD10.04c 4787160 4787774 - hypothetical protein SCD10.04c%2C unknown%2C len: 204 aa gene gene4419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4372 SCO4373 SCO4373 SCD10.05c SCD10.05c 4787839 4788393 - mut-like protein SCD10.05c%2C possible mut-like protein%2C len: 184 aa%3B similar to SW:YZGD_BACSU (EMBL:U17168) Bacillus subtilis hypothetical 45.4 kD protein in thiaminase I 5' region YgzD%2C 413 aa%3B fasta scores: opt: 225 z-score: 279.9 E(): 4.1e-08%3B 35.1%25 identity in 148 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and match to Prosite entry PS00893 mutT domain signature gene gene4420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4373 SCO4374 SCO4374 SCD10.06 SCD10.06 4788577 4789464 + hypothetical protein SCD10.06%2C possible integral membrane protein%2C len: 295 aa%3B similar to TR:Q9RUT6 (EMBL:AE001976) Deinococcus radiodurans PecM-related protein DR1295%2C 302 aa%3B fasta scores: opt: 769 z-score: 839.6 E(): 0%3B 47.1%25 identity in 291 aa overlap. Contains Pfam match to entry PF00892 DUF6%2C Integral membrane protein. Contains also possible hydrophobic membrane spanning regions gene gene4421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4374 SCO4375 SCO4375 SCD10.07 SCD10.07 4789565 4790059 + MarR family regulatory protein SCD10.07%2C possible marR-family regulatory protein%2C len: 164 aa%3B similar to TR:CAB87337 (EMBL:AL163672) Streptomyces coelicolor regulatory protein SCE50.15%2C 168 aa%3B fasta scores: opt: 226 z-score: 281.6 E(): 3.3e-08%3B 39.3%25 identity in 135 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene4422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4375 SCO4376 SCO4376 SCD10.08 SCD10.08 4790056 4790565 + hypothetical protein SCD10.08%2C unknown%2C len: 169 aa. Contains 3x degenerate repeat: T(T/A)P and a 2x conserved repeat TTDAA gene gene4423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4376 SCO4377 SCO4377 SCD10.09 SCD10.09 4790669 4792411 + serine-threonine protein kinase SCD10.09%2C probable serine-threonine protein kinase%2C len: 580 aa%3B similar to SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor serine-threonine protein kinase AfsK (EC 2.7.1.-)%2C 799 aa%3B fasta scores: opt: 953 z-score: 715.3 E(): 2.3e-32%3B 43.2%25 identity in 438 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature. Contains possible hydrophobic membrane spanning region gene gene4424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4377 SCO4378 SCO4378 SCD10.10 SCD10.10 4792544 4793374 + hypothetical protein SCD10.10%2C conserved hypothetical protein%2C len: 276 aa%3B similar to SW:YO36_MYCTU (EMBL:Z80233) Mycobacterium tuberculosis hypothetical 27.6 kD protein CY10H4.36c%2C 257 aa%3B fasta scores: opt: 1065 z-score: 1157.0 E(): 0%3B 61.5%25 identity in 257 aa overlap gene gene4425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4378 SCO4379 SCO4379 SCD10.11 SCD10.11 4793371 4795047 + hypothetical protein SCD10.11%2C conserved hypothetical protein%2C len: 558 aa%3B similar to TR:O86320 (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 59.1 kD protein aa%3B fasta scores: opt: 2549 z-score: 2481.8 E(): 0%3B 69.0%25 identity in 562 aa overlap gene gene4426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4379 SCO4380 SCO4380 SCD10.12 SCD10.12 4795085 4796683 + acetyl/propionyl CoA carboxylase subunit beta SCD10.12%2C probable acetyl/propionyl CoA carboxylase%2C beta subunit%2C len: 532 aa%3B similar to TR:O86318 (EMBL:Z79700) Mycobacterium tuberculosis AccD2%2C 529 aa%3B fasta scores: opt: 2691 z-score: 3002.4 E(): 0%3B 75.5%25 identity in 530 aa overlap and to TR:AAF35258 (EMBL:AF059510) Arabidopsis thaliana 3-methylcrotonyl-CoA carbosylase non-biotinylated subunit (EC 6.4.1.4) MccB%2C 587 aa%3B fasta scores: opt: 1186 z-score: 1323.2 E(): 0%3B 48.0%25 identity in 546 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans%2C Carboxyl transferase domain gene gene4427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4380 SCO4381 SCO4381 SCD10.13 SCD10.13 4796697 4798541 + acetyl/propionyl CoA carboxylase subunit alpha SCD10.13%2C probable acetyl/propionyl CoA carboxylase%2C alpha subunit%2C len: 614 aa%3B similar to TR:CAB87214 (EMBL:AL163641) Streptomyces coelicolor acetyl/propionyl CoA carboxylase%2C alpha subunit AccC%2C 646 aa%3B fasta scores: opt: 1088 z-score: 1184.1 E(): 0%3B 46.6%25 identity in 644 aa overlap and to SW:BCCA_MYCTU (EMBL:Z19549) Mycobacterium tuberculosis acetyl/propionyl-coenzyme A carboxylase alpha chain AccA1%2C 654 aa %3Bfasta scores: opt: 939 z-score: 1022.0 E(): 0%3B 43.2%25 identity in 655 aa overlap. Contains 2x Pfam matches to entry PF00289 CPSase_L_chain%2C Carbamoyl-phosphate synthase (CPSase)%2C Pfam match to entry PF00364 biotin_lipoyl%2C Biotin-requiring enzymes and matches to Prosite entries PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site gene gene4428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4381 SCO4382 SCO4382 SCD10.14 SCD10.14 4798612 4799760 + acyl CoA dehydrogenase SCD10.14%2C probable acyl CoA dehydrogenase%2C len: 382 aa%3B similar to SW:ACDB_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis probable acyl CoA dehydrogenase MTCY10D7.02%2C 388 aa%3B fasta scores: opt: 1694 z-score: 1964.7 E(): 0%3B 64.3%25 identity in 387 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene4429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4382 SCO4383 SCO4383 4CL-2 4CL-2 4799896 4801464 + 4-coumarate:CoA ligase SCD10.15%2C 4CL-2%2C 4-coumarate:CoA ligase%2C len: 522 aa%3B similar to many eukaryotic ones%2C e.g. TR:O81139 (EMBL:AF041049) Populus tremuloides 4-coumarate:CoA ligase (EC 6.2.1.12) 4CL2%2C 535 aa%3B fasta scores: opt: 1412 z-score: 1497.3 E(): 0%3B 44.2%25 identity in 532 aa overlap. Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and match to Prosite entry PS00455 AMP-binding domain signature gene gene4430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4383 SCO4384 SCO4384 SCD10.16 SCD10.16 4801461 4802204 + enoyl-CoA hydratase Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA gene gene4431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4384 SCO4385 SCO4385 SCD10.17 SCD10.17 4802213 4802821 + TetR family transcriptional regulator SCD10.17%2C probable tetR-family transcriptional regulator%2C len: 202 aa%3B similar to TR:O33453 (EMBL:U24215) Pseudomonas putida regulatory protein for cym and cmt operons%3B cym repressor CymR%2C 203 aa%3B fasta scores: opt: 245 z-score: 309.4 E(): 9.3e-10%3B 31.4%25 identity in 191 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Contains also a possible helix-turn-helix motif at residues 39..60 (+3.02 SD) gene gene4432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4385 SCO4386 SCO4386 SCD10.18 SCD10.18 4802849 4803460 + hypothetical protein SCD10.18%2C unknown%2C len: 203 aa gene gene4433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4386 SCO4387 SCO4387 SCD10.19c SCD10.19c 4803479 4804183 - pyridoxamine oxidase SCD10.19c%2C probable pyridoxamine oxidase%2C len: 234 aa%3B similar to SW:PDXH_ECOLI (EMBL:M92351) Escherichia coli pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) PdxH%2C 217 aa%3B fasta scores: opt: 717 z-score: 876.3 E(): 0%3B 49.1%25 identity in 212 aa overlap. Contains Pfam match to entry PF01243 Pyridox_oxidase%2C Pyridoxamine 5'-phosphate oxidase and match to Prosite entry PS01064 Pyridoxamine 5'-phosphate oxidase signature gene gene4434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4387 SCO4388 SCO4388 SCD10.20 SCD10.20 4804464 4805564 + citrate synthase 2 forms citrate from oxaloacetate and acetyl-CoA%3B functions in TCA cycle gene gene4435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4388 SCO4389 SCO4389 SCD10.21 SCD10.21 4805897 4806772 + acetyltransferase SCD10.21%2C possible acetyltransferase%2C len: 291 aa%3B N-terminal domain similar to TR:Q9S2T6 (EMBL:AL096884) Streptomyces coelicolor conserved hypothetical protein SC4G6.18c%2C 134 aa%3B fasta scores: opt: 259 z-score: 321.5 E(): 2e-10%3B 39.8%25 identity in 128 aa overlap and C-terminal domain similar to TR:Q9S2P7 (EMBL:AL096872) Streptomyces coelicolor acetyltransferase SC5F7.12c%2C 169 aa%3B blastp scores: Score %3D 90 (31.7 bits)%2C Expect %3D 0.043%2C P %3D 0.042 Identities %3D 37/125 (29%25)%2C Positives %3D 53/125 (42%25). Contains Pfam matches to entries PF01042 UPF0076%2C Domain of unknown function and PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene4436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4389 SCO4390 SCO4390 SCD10.22 SCD10.22 4806938 4808341 + hypothetical protein SCD10.22%2C hypothetical protein%2C len: 467 aa%3B similar to TR:CAB92197 (EMBL:AL356592) Streptomyces coelicolor hypothetical 84.7 kD protein SC9H11.08%2C 802 aa%3B fasta scores: opt: 261 z-score: 286.0 E(): 1.9e-08%3B 29.2%25 identity in 463 aa overlap. Contains 2 Pfam matches to entry PF00989 PAS%2C PAS domain and Pfam match to entry PF00785 PAC%2C PAC motif gene gene4437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4390 SCO4391 SCO4391 SCD10.23c SCD10.23c 4808387 4808785 - hypothetical protein SCD10.23c%2C conserved hypothetical protein%2C len: 132 aa%3B similar to TR:O86547 (EMBL:AL031350) Streptomyces coelicolor hypothetical 15.3 kD protein SC1F2.10%2C 135 aa%3B fasta scores: opt: 316 z-score: 419.7 E(): 6.7e-16%3B 45.1%25 identity in 122 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function gene gene4438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4391 SCO4392 SCO4392 SCD10.24 SCD10.24 4808960 4809685 + esterase SCD10.24%2C possible esterase%2C len: 241 aa%3B similar to TR:Q9RBI4 (EMBL:AF150928) Acinetobacter sp. ADP1 alkyl salicylate esterase SalE%2C 239 aa%3B fasta scores: opt: 360 z-score: 411.1 E(): 2e-15%3B 28.6%25 identity in 241 aa overlap gene gene4439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4392 SCO4393 SCO4393 SCD10.25c SCD10.25c 4809858 4810613 - hypothetical protein SCD10.25c%2C hypothetical protein%2C len: 251 aa%3B similar to SW:YFEU_ECOLI (EMBL:AE000330) Escherichia coli hypothetical 31.2 kD protein in CysP-AmiA intergenic region YfeU%2C 298 aa%3B fasta scores: opt: 147 z-score: 178.1 E(): 0.019%3B 27.0%25 identity in 185 aa overlap gene gene4440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4393 SCO4394 SCO4394 desR desR 4810836 4811528 + iron repressor SCD10.26%2C desR%2C probable iron repressor%2C len: 230 aa%3B identical to TR:Q54343 (EMBL:Z50049) Streptomyces lividans iron repressor DesR%2C 230 aa. Contains Pfam match to entry PF01325 Fe_dep_repress%2C Iron dependent repressor. Contains also a possible helix-turn-helix motif at residues 25..46 (+2.65 SD) gene gene4441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4394 SCO4395 SCO4395 SCD10.27 SCD10.27 4811888 4812946 + hydrolase SCD10.27%2C possible hydrolase%2C len: 352 aa%3B similar to TR:Q9RCX1 (EMBL:AL133469) Streptomyces coelicolor hydrolase SCM10.27c%2C 287 aa%3B fasta scores: opt: 290 z-score: 298.8 E(): 3.6e-09%3B 28.5%25 identity in 277 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene4442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4395 SCO4396 SCO4396 SCD10.28c SCD10.28c 4812954 4814606 - integral membrane transport protein SCD10.28c%2C possible integral membrane transport protein%2C len: 550 aa%3B similar to SW:MER4_STRLI (EMBL:X65467) Streptomyces lividans mercury resistance probable Hg transport protein Mer4%2C 319 aa%3B fasta scores: opt: 139 z-score: 153.9 E(): 0.43%3B 27.9%25 identity in 308 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4396 SCO4397 SCO4397 SCD10.29c SCD10.29c 4814603 4815394 - ABC transporter ATP-binding protein SCD10.29c%2C probable ABC transport system ATP-binding protein%2C len: 263 aa%3B similar to TR:Q9WZQ0 (EMBL:AE001747) Thermotoga maritima ABC transporter ATP-binding protein TM0793%2C 260 aa%3B fasta scores: opt: 591 z-score: 670.1 E(): 7.6e-30%3B 36.9%25 identity in 244 aa overlap and to SW:DRRA_STRPE (EMBL:M73758) Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA%2C 330 aa%3B fasta scores: opt: 551 z-score: 623.8 E(): 2.8e-27%3B 39.1%25 identity in 225 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4397 SCO4398 SCO4398 SCD10.30c SCD10.30c 4815510 4816163 - hypothetical protein SCD10.30c%2C conserved hypothetical protein%2C len: 217 aa%3B similar to TR:Q9ZBP8 (EMBL:AL034447) Streptomyces coelicolor hypothetical 23.3 kD protein SC7A1.25c%2C 223 aa%3B fasta scores: opt: 514 z-score: 621.6 E(): 3.8e-27%3B 45.0%25 identity in 189 aa overlap gene gene4445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4398 SCO4399 SCO4399 SCD10.31 SCD10.31 4816468 4817853 + hypothetical protein SCD10.31%2C conserved hypothetical protein%2C len: 461 aa%3B similar to TR:Q53958 (EMBL:M80614) Streptomyces coelicolor sporulation-associated protein genes%2C complete CDS%2C 473 aa%3B fasta scores: opt: 666 z-score: 723.4 E(): 8.1e-33%3B 43.8%25 identity in 464 aa overlap gene gene4446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4399 SCO4400 SCO4400 SCD10.32 SCD10.32 4818113 4819708 + hypothetical protein SCD10.32%2C possible membrane protein%2C len: 531 aa. Contains possible hydrophobic membrane spanning region and high content in alanine%2C glycine and proline amino acid residues. Also high G+C content (79.03%25) and a 3x degenerate repeat unit: GGR gene gene4447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4400 SCO4401 SCO4401 SCD10.33c SCD10.33c 4819767 4821083 - lipoprotein SCD10.33c%2C possible lipoprotein%2C len: 438 aa%3B N-terminal domain similar to N-terminal domain of TR:O68027 (EMBL:AF010496) Rhodobacter capsulatus potential Leu/Ile/Val-binding protein precursor%2C 400 aa%3B fasta scores: opt: 151 z-score: 166.0 E(): 0.09%3B 29.8%25 identity in 131 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4401 SCO4402 SCO4402 SCD10.34 SCD10.34 4821200 4821700 + hypothetical protein SCD10.34%2C unknown%2C len: 166 aa gene gene4449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4402 SCO4403 SCO4403 purU purU 4821748 4822641 + formyltetrahydrofolate deformylase produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis%3B has a role in one-carbon metabolism%3B forms a homohexamer%3B activated by methionine and inhibited by glycine gene gene4450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4403 SCO4404 SCO4404 SC6F11.02c SC6F11.02c 4822683 4823471 - ABC transporter SC6F11.02c%2C probable ABC transport system integral membrane protein%2C len: 262 aa%3B similar to TR:BAB07697 (EMBL:AP001520) Bacillus halodurans ABC transporter (permease) BH3978%2C 249 aa%3B fasta scores: opt: 669 z-score: 757.4 E(): 0%3B 41.7%25 identity in 247 aa overlap. Contains Pfam match to entry PF01061 ABC2_membrane%2C ABC-2 type transporter and possible hydrophobic membrane spanning regions gene gene4451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4404 SCO4405 SCO4405 SC6F11.03c SC6F11.03c 4823468 4824442 - ABC transporter ATP-binding protein SC6F11.03c%2C probable ABC transport system ATP-binding protein%2C len: 324 aa%3B similar to SW:DRRA_STRPE (EMBL:M73758) Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA%2C 330 aa%3B fasta scores: opt: 857 z-score: 908.1 E(): 0%3B 45.3%25 identity in 322 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4405 SCO4406 SCO4406 SC6F11.04c SC6F11.04c 4824455 4825120 - hypothetical protein SC6F11.04c%2C unknown%2C len: 21 aa gene gene4453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4406 SCO4407 SCO4407 SC6F11.05 SC6F11.05 4825352 4826125 + hypothetical protein SC6F11.05%2C hypothetical protein%2C len: 257 aa%3B partially similar to TR:Q9X8P9 (EMBL:AL049754) Streptomyces coelicolor hypothetical 17.1 kDa protein SCH10.10c%2C 152 aa%3B fasta scores: opt: 314 z-score: 367.2 E(): 6e-13 40.4%25 identity in 141 aa overlap gene gene4454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4407 SCO4408 SCO4408 SC6F11.06c SC6F11.06c 4826082 4827368 - hypothetical protein SC6F11.06c%2C unknown%2C len: 428 aa. Contains 4x degenerate repeat unit: (G/T)GTG gene gene4455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4408 SCO4409 SCO4409 SC6F11.07c SC6F11.07c 4827365 4827958 - RNA polymerase sigma factor SC6F11.07c%2C possible RNA polymerase sigma factor%2C len: 197 aa%3B similar to SW:SIGZ_BACSU (EMBL:U93875) Bacillus subtilis RNA polymerase sigma factor SigZ%2C 176 aa%3B fasta scores: opt: 166 z-score: 208.5 E(): 0.00041%3B 27.0%25 identity in 148 aa overlap gene gene4456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4409 SCO4410 SCO4410 SC6F11.08 SC6F11.08 4828287 4828667 + anti anti sigma factor SC6F11.08%2C possible anti anti sigma factor%2C len: 126 aa%3B similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist BldG%2C 113 aa%3B fasta scores: opt: 195 z-score: 264.4 E(): 3.2e-07%3B 30.8%25 identity in 104 aa overlap. Contains Pfam match to entry PF01740 STAS%2C STAS domain gene gene4457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4410 SCO4411 SCO4411 SC6F11.09 SC6F11.09 4828773 4829285 + calcium binding protein SC6F11.09%2C probable calcium binding protein%2C len: 170 aa%3B similar to SW:CBP_SACER (EMBL:M29700) Saccharopolyspora erythraea calerythrin (calcium-binding protein)%2C 177 aa%3B fasta scores: opt: 229 z-score: 267.7 E(): 2.1e-07%3B 28.6%25 identity in 154 aa overlap. Contains 4x Pfam matches to entry PF00036 efhand%2C EF hand and 3x matches to Prosite entry PS00018 EF-hand calcium-binding domain gene gene4458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4411 SCO4412 SCO4412 SC6F11.10 SC6F11.10 4829856 4830347 + regulatory protein SC6F11.10%2C possible regulatory protein%2C len: 163 aa%3B similar to TR:Q9ZBT2 (EMBL:AL034446) Streptomyces coelicolor regulatory protein SC1A9.20%2C 135 aa%3B fasta scores: opt: 227 z-score: 286.6 E(): 1.8e-08%3B 43.0%25 identity in 135 aa overlap gene gene4459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4412 SCO4413 SCO4413 SC6F11.11c SC6F11.11c 4830650 4831684 - AraC family transcription regulator SC6F11.11c%2C probable araC family transcriptional regulatory protein%2C len: 344 aa%3B highly similar to TR:Q9S166 (EMBL:AB023785) Streptomyces griseus AdpA%2C 405 aa%3B fasta scores: opt: 881 z-score: 1024.1 E(): 0%3B 46.9%25 identity in 322 aa overlap and to TR:CAB70646 (EMBL:AL137242) Streptomyces coelicolor transcriptional regulator SC8F4.20c%2C 337 aa%3B fasta scores: opt: 1237 z-score: 1238.7 E(): 0%3B 60.3%25 identity in 325 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and a possible helix-turn-helix motif at residues 249..270 (+2.55 SD) gene gene4460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4413 SCO4414 SCO4414 SC6F11.12 SC6F11.12 4831769 4833094 + integral membrane transport protein SC6F11.12%2C possible integral membrane protein%2C len: 441 aa%3B similar to TR:BAB06413 (EMBL:AP001516) Bacillus halodurans transporter BH2694%2C 418 aa%3B fasta scores: opt: 795 z-score: 909.8 E(): 0%3B 31.0%25 identity in 413 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4414 SCO4415 SCO4415 SC6F11.13 SC6F11.13 4833116 4833988 + hypothetical protein SC6F11.13%2C possible integral membrane protein%2C len: 290 aa. Contains possible hydrophobic membrane spanning regions gene gene4462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4415 SCO4416 SCO4416 SC6F11.14c SC6F11.14c 4834171 4835376 - monooxygenase SC6F11.14c%2C probable monooxygenase%2C len: 401 aa%3B similar to TR:Q9SDE6 (EMBL:AP000837) Oryza sativa similar to human dimethylanilyne monooxygenase%2C 437 aa%3B fasta scores: opt: 692 z-score: 722.8 E(): 9.3e-33%3B 38.2%25 identity in 403 aa overlap. Contains Pfam match to entry PF00743 FMO-like%2C Flavin-binding monooxygenase-like gene gene4463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4416 SCO4417 SCO4417 SC6F11.15 SC6F11.15 4835476 4836093 + acetyltransferase SC6F11.15%2C probable acetyltransferase%2C len: 205 aa%3B similar to SW:RIML_ECOLI (EMBL:X15860) Escherichia coli ribosomal-protein-serine acetyltransferase (EC 2.3.1.-) RimL%2C 179 aa%3B fasta scores: opt: 199 z-score: 261.1 E(): 4.8e-07%3B 30.6%25 identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene4464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4417 SCO4418 SCO4418 SC6F11.16c SC6F11.16c 4836101 4836769 - oxidase SC6F11.16c%2C probable oxidase%2C len: 222 aa%3B similar to TR:O88794 (EMBL:U91561) Rattus norvegicus pyridoxine 5'-phosphate oxidase PnpO%2C 261 aa%3B fasta scores: opt: 413 z-score: 479.7 E(): 3.2e-19%3B 38.0%25 identity in 184 aa overlap. Contains Pfam match to entry PF01243 Pyridox_oxidase%2C Pyridoxamine 5'-phosphate oxidase gene gene4465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4418 SCO4419 SCO4419 SC6F11.17c SC6F11.17c 4836783 4837208 - hypothetical protein SC6F11.17c%2C conserved hypothetical protein%2C len: 141 aa%3B similar to TR:O52559 (EMBL:AF040570) Amycolatopsis mediterranei hypothetical 18.7 kDa protein%2C 166 aa%3B fasta scores: opt: 372 z-score: 489.5 E(): 9.3e-20%3B 44.3%25 identity in 140 aa overlap gene gene4466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4419 SCO4420 SCO4420 SC6F11.18 SC6F11.18 4837226 4837537 + hypothetical protein SC6F11.18%2C unknown%2C len: 103 aa. Contains 6x conserved repeat: MR gene gene4467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4420 SCO4421 SCO4421 SC6F11.19c SC6F11.19c 4837557 4838192 - TetR family transcriptional regulator SC6F11.19c%2C possible tetR-family transcriptional regulatory protein%2C len: 211 aa%3B similar to TR:Q9RD77 (EMBL:AL136502) Streptomyces coelicolor tetR-family regulatory protein SCF43.11c%2C 205 aa%3B fasta scores: opt: 156 z-score: 196.9 E(): 0.0018%3B 28.2%25 identity in 131 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 36..57 (+4.34 SD) gene gene4468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4421 SCO4422 SCO4422 SC6F11.20 SC6F11.20 4838327 4839085 + hydrolase SC6F11.20%2C possible hydrolase%2C len: 252 aa%3B similar to TR:Q9X7R7 (EMBL:AL049863) Streptomyces coelicolor hydrolase SC5H1.09c%2C 265 aa%3B fasta scores: opt: 465 z-score: 555.8 E(): 1.9e-23%3B 40.1%25 identity in 252 aa overlap gene gene4469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4422 SCO4423 SCO4423 afsK afsK 4839304 4841703 + Ser/Thr protein kinase SC6F11.21%2C afsK%2C Ser/Thr protein kinase%2C len: >161 aa%3B identical to N-terminal region of previously sequenced SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor Ser/Thr protein kinase AfsK%2C 799 aa. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and match to Prosite entry PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature~SCD6.01%2C afsK%2C Ser/Thr protein kinase%2C len: >671 aa%3B identical to C-terminal region of SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor Ser/Thr protein kinase AfsK%2C 799 aa and highly similar to the C-terminal region of TR:CAB45488 Streptomyces coelicolor Ser/Thr protein kinase SC66T3.32c%2C 783 aa%3B fasta scores: opt: 521 z-score: 329.5 E(): 7.7e-13%3B 40.6%25 identity in 266 aa overlap. Contains Pfam matches to entries PF00069 pkinase%2C Eukaryotic protein kinase domain and 8x PF01011 Bacterial_PQQ%2C PQQ enzyme repeat and match to Prosite entry PS00108 Ser/Thr protein kinases active-site signature gene gene4470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4423 SCO4424 SCO4424 SCD6.02 SCD6.02 4841760 4842290 + hypothetical protein SCD6.02%2C possible hypothetical protein%2C len: 176 aa%3B almost identical to TR:Q53910 (EMBL:D45382) Streptomyces coelicolor ORFB%2C 175 aa. Contains possible N-terminal region signal peptide sequence gene gene4471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4424 SCO4425 SCO4425 afsR2 afsR2 4842382 4842573 - sigma-like protein SCD6.03c%2C afsR2%2C regulator of antibiotic production%2C len: 63 aa%3B identical to previously sequenced TR:Q57058 (EMBL:D45382) Streptomyces coelicolor AfsR2%2C 63 aa gene gene4472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4425 SCO4426 SCO4426 afsR afsR 4842787 4845768 - regulatory protein SCD6.04c%2C afsR%2C regulatory protein%2C len: 993 aa%3B identical to previously sequenced SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR%2C 993 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4426 SCO4427 SCO4427 SCD6.05c SCD6.05c 4845862 4846281 - hypothetical protein SCD6.05c%2C hypothetical protein%2C len: 139 aa%3B similar to TR:P95144 (EMBL:Z83859) Mycobacterium tuberculosis hypothetical 14.7 kD protein MTCY359.02%2C 129 aa%3B fasta scores: opt: 462 z-score: 578.8 E(): 8.8e-25%3B 58.2%25 identity in 134 aa overlap gene gene4474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4427 SCO4428 SCO4428 SCD6.06c SCD6.06c 4846352 4847875 - hypothetical protein SCD6.06c%2C possible hypothetical protein%2C len: 507 aa. Contains possible N-terminal region signal peptide sequence gene gene4475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4428 SCO4429 SCO4429 fbiC fbiC 4848064 4850667 + FO synthase 7%2C8-didemethyl-8-hydroxy-5-deazariboflavin synthase%3B catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2%2C4(1H%2C3H)-pyrimidinedione to form 7%2C8-didemethyl-8-hydroxy-5-deazariboflavin (FO)%3B functions in F420 biosynthesis gene gene4476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4429 SCO4430 SCO4430 SCD6.08 SCD6.08 4850736 4851305 + hypothetical protein SCD6.08%2C possible hypothetical protein%2C len: 189 aa%3B similar to TR:O86790 (EMBL:AL031317) Streptomyces coelicolor hypothetical protein SC6G4.27c%2C 184 aa%3B fasta scores: opt: 495 z-score: 536.2 E(): 2.1e-22%3B 48.1%25 identity in 181 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4430 SCO4431 SCO4431 SCD6.09c SCD6.09c 4851343 4851852 - hypothetical protein SCD6.09c%2C possible integral membrane protein%2C len: 169 aa. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene4478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4431 SCO4432 SCO4432 SCD6.10 SCD6.10 4851904 4852578 + hypothetical protein SCD6.10%2C unknown%2C len: 224 aa gene gene4479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4432 SCO4433 SCO4433 SCD6.11c SCD6.11c 4852634 4853044 - hypothetical protein SCD6.11c%2C possible integral membrane protein%2C len: 136 aa%3B similar to TR:O32937 (EMBL:Z98604) Mycobacterium leprae hypothetical 12.4 kD protein%2C 117 aa%3B fasta scores: opt: 308 z-score: 355.9 E(): 2.3e-12%3B 52.4%25 identity in 105 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4433 SCO4434 SCO4434 SCD6.12 SCD6.12 4853069 4853965 + LysR family transcriptional regulator SCD6.12%2C probable LysR-family transcriptional regulator%2C len: 298 aa%3B similar to TR:Q9X9U9 (EMBL:Y18817) Streptomyces coelicolor A3(2) transcriptional regulator of LysR family%2C 307 aa%3B fasta scores: opt: 736 z-score: 859.4 E(): 0%3B 43.6%25 identity in 303 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family%2C match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature and possible helix-turn-helix motif at residues 18..39 (+4.94 SD) gene gene4481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4434 SCO4435 SCO4435 SCD6.13 SCD6.13 4854071 4855186 + hypothetical protein SCD6.13%2C unknown%2C len: 371 aa. High content in alanine%2C glycine and leucine amino acid residues and also high G+C content (78.43%25) gene gene4482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4435 SCO4436 SCO4436 SCD6.14 SCD6.14 4855250 4855660 + lyase SCD6.14%2C possible lyase%2C len: 136 aa%3B highly similar to TR:O86701 (EMBL:AL031515) Streptomyces coelicolor lyase SC5C7.04%2C 138 aa%3B fasta scores: opt: 532 z-score: 662.4 E(): 2e-29%3B 53.7%25 identity in 136 aa overlap gene gene4483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4436 SCO4437 SCO4437 SCD6.15c SCD6.15c 4855908 4857491 - sodium-coupled permease SCD6.15c%2C possible sodium-coupled permease%2C len: 527 aa%3B similar to TR:P74252 (EMBL:D90913) Synechocystis sp. sodium-coupled permease%2C 512 aa%3B fasta scores: opt: 451 z-score: 531.6 E(): 3.8e-22%3B 26.3%25 identity in 510 aa overlap. Contains Pfam match to entry PF00474 SSF%2C Sodium:solute symporter family and possible hydrophobic membrane spanning regions gene gene4484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4437 SCO4438 SCO4438 SCD6.16c SCD6.16c 4857727 4859604 - hypothetical protein SCD6.16c%2C possible integral membrane protein%2C len: 625 aa%3B similar to TR:Q9KXI6 (EMBL:AL357591) Streptomyces coelicolor integral membrane protein SCC53.25%2C 551 aa%3B fasta scores: opt: 1266 Z-score: 1316.1 bits: 253.5 E(): 1.1e-65%3B 42.430%25 identity in 502 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4438 SCO4439 SCO4439 SCD6.17c SCD6.17c 4859813 4862311 - D-alanyl-D-alanine carboxypeptidase SCD6.17c%2C possible D-alanyl-D-alanine carboxypeptidase%2C len: 832 aa%3B similar to TR:O54201 (EMBL:AJ001743) Streptomyces clavuligerus Pbp2 protein (penicillin binding protein PbpA)%2C 696 aa%3B fasta scores: opt: 955 z-score: 744.1 E(): 0%3B 37.0%25 identity in 757 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11%2C D-alanyl-D-alanine carboxypeptidase and high content in alanine%2C aspartic acid and glycine amino acid residues. Contains degenerate repeats: 2X (G/A)GAAPDSGSG(T/A)DATXXXPAPD(T/A) KPDQEPDADSEPAPDAQAASSRDGDAD gene gene4486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4439 SCO4440 SCO4440 SCD6.18 SCD6.18 4862642 4863400 + hypothetical protein SCD6.18%2C hypothetical protein%2C len: 252 aa%3B similar to TR:Q9X7M7 (EMBL:AL049587) Streptomyces coelicolor integral membrane protein SC5F2A.04%2C 302 aa%3B fasta scores: opt: 228 z-score: 237.1 E(): 9.5e-06%3B 32.6%25 identity in 224 aa overlap gene gene4487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4440 SCO4441 SCO4441 SCD6.19 SCD6.19 4863620 4864507 + DNA-binding protein SCD6.19%2C possible DNA-binding protein%2C len: 295 aa%3B similar to many other S. coelicolor hypothetical proteins%2C e.g. TR:Q9X8K0 (EMBL:AL049841) Streptomyces coelicolor hypothetical 30.9 kD protein SCE9.28c%2C 274 aa%3B fasta scores: opt: 717 z-score: 834.5 E(): 0%3B 42.6%25 identity in 263 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 37..58 (+5.84 SD) gene gene4488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4441 SCO4442 SCO4442 SCD6.20 SCD6.20 4864681 4864872 + hypothetical protein SCD6.20%2C hypothetical protein%2C len: 63 aa%3B similar to many other S. coelicolor hypothetical proteins%2C e.g. TR:CAB62714 (EMBL:AL133423) Streptomyces coelicolor hypothetical 6.9 kD protein SC4A7.10%2C 65 aa%3B fasta scores: opt: 159 z-score: 242.8 E(): 4.6e-06%3B 50.9%25 identity in 55 aa overlap gene gene4489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4442 SCO4443 SCO4443 SCD6.21c SCD6.21c 4864966 4865850 - MerR family transcriptional regulator SCD6.21c%2C possible merR-family transcriptional regulator%2C len: 294 aa%3B similar to TR:AAF11989 (EMBL:AE002074) Deinococcus radiodurans transcriptional regulator%2C merR-family DR2448%2C 280 aa%3B fasta scores: opt: 465 z-score: 562.4 E(): 7.3e-24%3B 43.0%25 identity in 286 aa overlap. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and match to Prosite entry PS00552 Bacterial regulatory proteins%2C merR family signature gene gene4490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4443 SCO4444 SCO4444 SCD6.22c SCD6.22c 4865924 4866505 - glutathione peroxidase SCD6.22c%2C probable glutathione peroxidase%2C len: 193 aa%3B similar to SW:GPO_LACLC (EMBL:AJ000109) Lactococcus lactis glutathione peroxidase (EC 1.11.1.9) Gpo%2C 157 aa%3B fasta scores: opt: 530 z-score: 660.6 E(): 2.4e-29%3B 54.9%25 identity in 142 aa overlap. Contains Pfam match to entry PF00255 GSHPx%2C Glutathione peroxidases and match to Prosite entry PS00460 Glutathione peroxidases selenocysteine active site gene gene4491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4444 SCO4445 SCO4445 SCD6.23c SCD6.23c 4866642 4867625 - transcriptional regulator SCD6.23c%2C possible transcriptional regulator%2C len: 327 aa%3B similar to TR:Q9XBC8 (EMBL:AL078635) Streptomyces coelicolor transcriptional regulator CZA382.23c%2C 335 aa%3B fasta scores: opt: 347 z-score: 400.5 E(): 7.5e-15%3B 36.7%25 identity in 270 aa overlap gene gene4492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4445 SCO4446 SCO4446 SCD6.24 SCD6.24 4867733 4868950 + hypothetical protein SCD6.24%2C possible integral membrane protein%2C len: 405 aa%3B similar to TR:CAB72211 (EMBL:AL138851) Streptomyces coelicolor transport protein SCE59.24%2C 366 aa%3B fasta scores: opt: 204 z-score: 229.5 E(): 2.5e-05%3B 27.1%25 identity in 358 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4446 SCO4447 SCO4447 SCD6.25 SCD6.25 4869137 4870225 + hypothetical protein SCD6.25%2C possible integral membrane protein%2C len: 362 aa%3B similar to TR:CAB56388 (EMBL:AL118515) Streptomyces coelicolor integral membrane protein SCD17.11%2C 454 aa%3B fasta scores: opt: 715 z-score: 760.4 E(): 0%3B 41.6%25 identity in 368 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4447 SCO4448 SCO4448 SCD6.26c SCD6.26c 4870304 4870987 - hypothetical protein SCD6.26c%2C unknown%2C len: 227 aa gene gene4495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4448 SCO4449 SCO4449 SCD6.27c SCD6.27c 4871042 4871941 - hydrolase SCD6.27c%2C probable hydrolase%2C len: 299 aa%3B similar to TR:O87275 (EMBL:AF015628) Staphylococcus cohnii streptogramin B lactonase VgbB%2C 295 aa%3B fasta scores: opt: 855 z-score: 887.0 E(): 0%3B 44.5%25 identity in 283 aa overlap. Contains 5x DNA degenerate repeats:G/R)(T/A)(G/R)RR(P/H)VVH gene gene4496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4449 SCO4450 SCO4450 SCD6.28 SCD6.28 4872011 4872658 + TetR family transcriptional regulator SCD6.28%2C probable tetR-family transcriptional regulator%2C len: 215 aa%3B similar to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR%2C 226 aa%3B fasta scores: opt: 295 z-score: 356.1 E(): 2.2e-12%3B 33.5%25 identity in 218 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 39..60 (+4.31 SD) gene gene4497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4450 SCO4451 SCO4451 SCD6.29 SCD6.29 4872768 4874393 + export protein SCD6.29%2C probable export protein%2C len: 541 aa%3B similar to TR:CAB61602 (EMBL:AL133210) Streptomyces coelicolor export protein%2C SCG11.21c%2C 533 aa%3B fasta scores: opt: 832 z-score: 842.6 E(): 0%3B 33.7%25 identity in 531 aa overlap and to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA%2C 538 aa%3B fasta scores: opt: 701 z-score: 710.8 E(): 3.9e-32%3B 29.3%25 identity in 543 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4451 SCO4452 SCO4452 SCD6.30c SCD6.30c 4874365 4875516 - RNA polymerase sigma factor SCD6.30c%2C hypothetical protein%2C len: 383 aa%3B similar to TR:O86798 (EMBL:AL031317) Streptomyces coelicolor hypothetical 45.7 kD protein SC6G4.35%2C 419 aa%3B fasta scores: opt: 312 z-score: 358.2 E(): 1.7e-12%3B 42.3%25 identity in 404 aa overlap and to many RNA polymerase sigma facotrs%2C e.g. TR:Q984U6 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) sigma-70 factor%2C ECF subfamily MLL7837 417 aa%3B fasta scores: opt: 535 Z-score: 594.4 E(): 1.8e-25%3B 43.325%25 identity in 397 aa overlap gene gene4499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4452 SCO4453 SCO4453 SCD6.31c SCD6.31c 4875525 4875932 - hypothetical protein SCD6.31c%2C hypothetical protein%2C len: 135 aa%3B similar to TR:O86797 (EMBL:AL031317) Streptomyces coelicolor hypothetical 13.2 kD protein%2C 118 aa%3B fasta scores: opt: 158 z-score: 203.7 E(): 0.00069%3B 34.0%25 identity in 103 aa overlap gene gene4500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4453 SCO4454 SCO4454 SCD6.32c SCD6.32c 4876023 4876625 - transcriptional regulator SCD6.32c%2C possible transcriptional regulator%2C len: 200 aa%3B similar to TR:O86514 (EMBL:AL031124) Streptomyces coelicolor transcriptional regulator SC1C2.13%2C 194 aa%3B fasta scores: opt: 342 z-score: 413.0 E(): 1.5e-15%3B 39.0%25 identity in 172 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 35..56 (+2.77 SD) gene gene4501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4454 SCO4455 SCO4455 SCD6.33 SCD6.33 4876807 4877370 + hypothetical protein SCD6.33%2C possible integral membrane protein%2C len: 187 aa%3B similar to TR:Q98DK3 (EMBL:AP003004) MLR4665 protein from Rhizobium loti (Mesorhizobium loti) fasta scores%3B opt: 419%2C Z-score: 476.1%2C E(): 6.9e-19%2C 43.373%25 identity (44.172%25 ungapped) in 166 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4455 SCO4456 SCO4456 SCD6.34 SCD6.34 4877431 4879017 + membrane-associated oxidoreductase SCD6.34%2C possible membrane-associated oxidoreductase%2C len: 528 aa%3B similar to TR:CAB52970 (EMBL:AL109950) Streptomyces coelicolor membrane-associated oxidoreductase SCJ4.36c%2C 503 aa%3B fasta scores: opt: 657 z-score: 776.7 E(): 0%3B 38.8%25 identity in 551 aa overlap. Contains possible C-terminal region hydrophobic membrane spanning domains gene gene4503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4456 SCO4457 SCO4457 SCD6.35c SCD6.35c 4879075 4880076 - hypothetical protein SCD6.35c%2C possible integral membrane protein%2C len: 333 aa. Contains possible hydrophobic membrane spanning regions gene gene4504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4457 SCO4458 SCO4458 SCD6.36c SCD6.36c 4880330 4880974 - lipoprotein SCD65.01c%2C possible lipoprotein (fragment)%2C len: >146 aa%3B similar to TR:Q55943 (EMBL:D64005) Synechocystis sp. hypothetical 22.9 kDa protein SLL0788%2C 196 aa%3B fasta scores: opt: 203 z-score: 217.8 E(): 0.00012%3B 33.9%25 identity in 118 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence~SCD6.36c%2C unknown (fragment)%2C len: > 107 aa gene gene4505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4458 SCO4459 SCO4459 SCD65.02c SCD65.02c 4881117 4881521 - hypothetical protein SCD65.02c%2C possible membrane protein%2C len: 134 aa. Contains possible hydrophobic membrane spanning region. High alanine and glycine amino acid residues content gene gene4506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4459 SCO4460 SCO4460 SCD65.03 SCD65.03 4881544 4882014 + hypothetical protein SCD65.03%2C hypothetical protein%2C len: 156 aa%3B similar to the C-terminal region of the SCP1 plasmid borne TR:Q9AD28 (EMBL:AL590463) Streptomyces coelicolor hypothetical protein SCP1.122%2C 246 aa%3B fasta scores: opt: 444 Z-score: 518.8 E(): 2.9e-21%3B 55.906%25 identity in 127 aa overlap. Contains match to Prosite entry PS00038 Myc-type%2C 'helix-loop-helix' dimerization domain signature gene gene4507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4460 SCO4461 SCO4461 SCD65.04c SCD65.04c 4882032 4882589 - TetR family transcriptional regulator SCD65.04c%2C possible tetR-family transcriptional regulatory protein%2C len: 185 aa%3B similar to SW:BETI_RHIME (EMBL:U39940) Rhizobium meliloti regulatory protein BetI%2C 203 aa%3B fasta scores: opt: 193 z-score: 251.5 E(): 1.5e-06%3B 27.3%25 identity in 183 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 33..54 (+3.34 SD) gene gene4508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4461 SCO4462 SCO4462 SCD65.05 SCD65.05 4882715 4883962 + hypothetical protein SCD65.05%2C possible integral membrane protein%2C len: 415 aa%3B similar to TR:P75810 (EMBL:AE000186) Escherichia coli MosC protein%2C 402 aa%3B fasta scores: opt: 1317 z-score: 1364.7 E(): 0%3B 54.1%25 identity in 392 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4462 SCO4463 SCO4463 SCD65.06 SCD65.06 4883959 4884108 + hypothetical protein SCD65.06%2C membrane protein%2C len: 49 aa%3B highly similar to the C-terminal region of SW:SUGE_ECOLI (EMBL:X69949) Escherichia coli SugE protein%2C chaperone%2C 105 aa%3B fasta scores: opt: 108 z-score: 175.6 E(): 0.028%3B 45.7%25 identity in 46 aa overlap. Contains match to Prosite entry PS00012 Phosphopantetheine attachment site. Contains possible hydrophobic membrane spanning regions gene gene4510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4463 SCO4464 SCO4464 SCD65.07c SCD65.07c 4884219 4884893 - hydrolase SCD65.07c%2C probable hydrolase%2C len: 224 aa%3B similar to SW:ENTB_ECOLI (EMBL:M24148) Escherichia coli isochorismatase (EC 3.3.2.1) EntB%2C 285 aa%3B fasta scores: opt: 245 z-score: 306.5 E(): 1.3e-09%3B 29.2%25 identity in 202 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family and a TTA leucine codon%2C possible target for bldA regulation gene gene4511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4464 SCO4465 SCO4465 SCD65.08c SCD65.08c 4884932 4885462 + hypothetical protein SCD65.08c%2C hypothetical protein%2C len: 176 aa%3B similar to TR:P71704 (EMBL:Z80775) Mycobacterium tuberculosis hypothetical 20.4 kDa protein precursor MTCY21D4.10c%2C 180 aa%3B fasta scores: opt: 278 z-score: 350.1 E(): 5.3e-12%3B 33.7%25 identity in 172 aa overlap gene gene4512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4465 SCO4466 SCO4466 SCD65.09c SCD65.09c 4885528 4886016 - hypothetical protein SCD65.09c%2C unknown%2C len: 162 aa gene gene4513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4466 SCO4467 SCO4467 SCD65.10c SCD65.10c 4886067 4886504 - hypothetical protein SCD65.10c%2C unknown%2C len: 145 aa gene gene4514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4467 SCO4468 SCO4468 SCD65.11c SCD65.11c 4886495 4886701 - hypothetical protein SCD65.11c%2C unknown%2C len: 68 aa gene gene4515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4468 SCO4469 SCO4469 hemL hemL 4886990 4888306 + glutamate-1-semialdehyde aminotransferase Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway gene gene4516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4469 SCO4470 SCO4470 SCD65.13 SCD65.13 4888303 4889004 + phosphoglycerate mutase SCD65.13%2C probable phosphoglycerate mutase%2C len: 233 aa%3B similar to SW:PMG2_ECOLI (EMBL:M97495) Escherichia coli probable phosphoglycerate mutase 2 (EC 5.4.2.1) GpmB%2C 215 aa%3B fasta scores: opt: 182 z-score: 227.1 E(): 3.5e-05%3B 26.5%25 identity in 215 aa overlap. Contains Pfam match to entry PF00300 PGAM%2C Phosphoglycerate mutase family gene gene4517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4470 SCO4471 SCO4471 SCD65.14 SCD65.14 4889161 4890459 + hypothetical protein SCD65.14%2C possible hypothetical protein%2C len: 432 aa%3B similar to TR:Q9X926 (EMBL:AL035636) Streptomyces coelicolor hypothetical protein SCH5.24c%2C 431 aa%3B fasta scores: opt: 1505 z-score: 1459.2 E(): 0%3B 50.0%25 identity in 438 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4471 SCO4472 SCO4472 SCD65.15 SCD65.15 4890549 4891220 + hypothetical protein SCD65.15%2C possible hypothetical protein%2C len: 223 aa%3B similar to TR:O06392 (EMBL:Z95558) Mycobacterium tuberculosis hypothetical 23.2 kDa protein MTCY25D10.05%2C 216 aa%3B fasta scores: opt: 431 z-score: 460.1 E(): 3.7e-18%3B 39.2%25 identity in 204 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4472 SCO4473 SCO4473 SCD65.16 SCD65.16 4891231 4891992 + cytochrome biogenesis-like protein SCD65.16%2C possible cytochrome biogenesis related protein%2C len: 253 aa%3B similar to SW:CCDA_BACSU (EMBL:X87845) Bacillus subtilis cytochrome C-type biogenesis protein CcdA%2C 235 aa: fasta scores: opt: 454 z-score: 507.4 E(): 8.5e-21%3B 33.3%25 identity in 228 aa overlap. Contains match to Prosite entry PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Also contains possible hydrophobic membrane spanning regions gene gene4520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4473 SCO4474 SCO4474 SCD65.17 SCD65.17 4891996 4893720 + hypothetical protein SCD65.17%2C possible integral membrane protein%2C len: 574 aa%3B similar to TR:O06394 (EMBL:Z95558) Mycobacterium tuberculosis hypothetical 57.1 kDa protein MTCY25D10.07%2C 529 aa%3B fasta scores: opt: 1079 z-score: 1222.2 E(): 0%3B 37.3%25 identity in 539 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4474 SCO4475 SCO4475 SCD65.18 SCD65.18 4893909 4895051 + cytochrome biogenesis-like protein SCD65.18%2C possible cytochrome biogenesis related protein%2C len: 380 aa%3B similar to SW:CCSA_GUITH (EMBL:X52159) Guillardia theta cytochrome biogenesis protein CcsA%2C 301 aa%3B fasta scores: opt: 455 z-score: 519.0 E(): 1.9e-21%3B 35.6%25 identity in 253 aa overlap. Contains Pfam match to entry PF01578 CytC_asm%2C Cytochrome C assembly protein and possible hydrophobic membrane spanning regions gene gene4522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4475 SCO4476 SCO4476 SCD65.19c SCD65.19c 4895198 4896619 - hypothetical protein SCD65.19c%2C hypothetical protein%2C len: 473 aa%3B similar to TR:O07803 (EMBL:Z97188) Mycobacterium tuberculosis hypothetical 52.1 kDa protein MTCY409.10%2C 468 aa%3B fasta scores: opt: 575 z-score: 663.0 E(): 1.8e-29%3B 27.8%25 identity in 464 aa overlap gene gene4523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4476 SCO4477 SCO4477 SCD65.20c SCD65.20c 4896795 4897511 - MerR family transcriptional regulator SCD65.20c%2C probable merR-family transcriptional regulatory protein%2C len: 238 aa%3B presents two hits to TR:Q9RKM5 (EMBL:AL138978) Streptomyces coelicolor merR family transcriptional regulator SCD17.06c%2C 319 aa%3B blastp scores for N-terminal domain: Score%3D 143 (50.3 bits)%2C Expect%3D 7.3e-08%2C P%3D 7.3e-08%3B Identities%3D 42/108 (38%25)%2C Positives%3D 57/108 (52%25) and blastp scores for C-terminal domain: Score%3D 102 (35.9 bits)%2C Expect%3D 0.0052%2C P%3D 0.0052%3B Identities%3D 33/96 (34%25)%2C Positives%3D 45/96 (46%25). Contains 2x Pfam matches to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and also two possible helix-turn-helix motives at residues 8..29 (+4.71 SD) and 130..151 (+4.79 SD) gene gene4524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4477 SCO4478 SCO4478 SCD65.21 SCD65.21 4897544 4898155 + transferase SCD65.21%2C possible transferase%2C len: 203 aa%3B similar to TR:Q9RWR3 (EMBL:AE001918) Deinococcus radiodurans cytidine/deoxycytidylate deaminase/nudix/methyltransferase domains protein DR603%2C 548 aa%3B fasta scores: opt: 447 z-score: 514.2 E(): 3.6e-21%3B 44.1%25 identity in 186 aa overlap. Contains match to Prosite entry PS00847 MCM family signature gene gene4525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4478 SCO4479 SCO4479 SCD65.22c SCD65.22c 4898224 4899117 - hydrolase SCD65.22c%2C possible hydrolase%2C len: 297 aa%3B similar to TR:O31386 (EMBL:Y10223) Bradyrhizobium japonicum b-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) PcaD%2C 260 aa%3B fasta scores: opt: 188 z-score: 220.7 E(): 8e-05%3B 32.1%25 identity in 156 aa overlap. Contains match to Prosite entry PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. Contains possible N-terminal region signal peptide sequence gene gene4526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4479 SCO4480 SCO4480 SCD65.23c SCD65.23c 4899301 4899918 - TetR family transcriptional regulator SCD65.23c%2C possible tetR-family transcriptional regulatory protein%2C len: 205 aa%3B similar to TR:O53661 (EMBL:AL021929) Mycobacterium tuberculosis regulatory protein MTV034.04%2C 204 aa%3B fasta scores: opt: 193 z-score: 241.7 E(): 5.4e-06%3B 25.7%25 identity in 187 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 37..58 (+2.77 SD) gene gene4527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4480 SCO4481 SCO4481 SCD65.24 SCD65.24 4900077 4901975 + Ser/Thr protein kinase SCD69.01%2C probable Ser/Thr protein kinase%2C len: >607 aa%3B similar to SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor Ser/Thr protein kinase AfsK%2C 799 aa%3B fasta scores: opt: 649 z-score: 427.0 E(): 2.5e-16%3B 35.8%25 identity in 408 aa overlap also similar to S. coelicolor SCD69.08 and TR:Q9ZN80 (EMBL:AB021679) Streptomyces coelicolor Ser/Thr protein kinase PkaG%2C 592 aa%3B fasta scores: opt: 715 z-score: 417.5 E(): 1e-17%3B 32.7%25 identity in 538 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature. Contains also a TTA leucine codon%2C possible target for bldA regulation~SCD65.24%2C probable Ser/Thr protein kinase%2C len: >56 aa%3B similar to SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor Ser/Thr protein kinase AfsK (EC 2.7.1.-)%2C 799 aa%3B fasta scores: opt: 137 z-score: 184.3 E(): 0.0092%3B 52.4%25 identity in 42 aa overlap and to TR:CAB92109 (EMBL:AL356334) Streptomyces coelicolor Ser/Thr protein kinase SCD69.08%2C 626 aa%3B fasta scores: opt: 316 z-score: 370.1 E(): 5.6e-15%3B 86.8%25 identity in 53 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and match to Prosite entry PS00107 Protein kinases ATP-binding region signature gene gene4528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4481 SCO4482 SCO4482 SCD69.02c SCD69.02c 4901972 4902832 - LysR family transcriptional regulator SCD69.02c%2C probable lysR-family transcriptional regulator%2C len: 286 aa%3B similar to TR:CAB55655 (EMBL:AL117385) Streptomyces coelicolor lysR-family transcriptional regulator SC5G9.07c%2C 287 aa%3B fasta scores: opt: 495 z-score: 551.1 E(): 3.1e-23%3B 37.0%25 identity in 297 aa overlap and to SW:ALSR_BACSU (EMBL:L04470) Bacillus subtilis als operon regulatory protein AlsR%2C 302 aa%3B fasta scores: opt: 390 z-score: 435.8 E(): 8.2e-17%3B 32.1%25 identity in 293 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains also possible helix-turn-helix motif at residues 19..42 (+4.15 SD) gene gene4529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4482 SCO4483 SCO4483 SCD69.03 SCD69.03 4902880 4903482 + hypothetical protein SCD69.03%2C hypothetical protein%2C len: 200 aa%3B similar to TR:Q9Z582 (EMBL:AL035569) Streptomyces coelicolor SC8D9.09 protein%2C 164 aa%3B fasta scores: opt: 246 z-score: 291.3 E(): 9.1e-09%3B 34.1%25 identity in 132 aa overlap gene gene4530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4483 SCO4484 SCO4484 SCD69.04 SCD69.04 4903479 4903841 + hypothetical protein SCD69.04%2C possible integral membrane protein%2C len: 120 aa%3B similar to TR:O85187 (EMBL:AF051158) Vibrio cholerae sodium-proton antiporter affecting protein NhaA%2C 382 aa%3B fasta scores: opt: 116 z-score: 146.3 E(): 1.1%3B 32.2%25 identity in 118 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4484 SCO4485 SCO4485 SCD69.05c SCD69.05c 4903856 4904881 - transcriptional regulator SCD69.05c%2C possible transcriptional regulator%2C len: 341 aa%3B similar to TR:CAB81864 (EMBL:AL161691) Streptomyces coelicolor deoR-family transcriptional regulator SCD40A.19c%2C 339 aa%3B fasta scores: opt: 480 z-score: 514.9 E(): 3.2e-21%3B 39.3%25 identity in 321 aa overlap. Contains possible helix-turn-helix motif at residues 21..42 (+5.42 SD) gene gene4532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4485 SCO4486 SCO4486 SCD69.06 SCD69.06 4904976 4905383 + hypothetical protein SCD69.06%2C hypothetical protein%2C len: 135 aa%3B similar to TR:Q9Z549 (EMBL:AL035212) Streptomyces coelicolor quinone protein SC9B2.10c%2C 130 aa%3B fasta scores: opt: 191 z-score: 257.8 E(): 6.8e-07%3B 34.6%25 identity in 127 aa overlap and to TR:Q98IY9 (EMBL:AP002999) Rhizobium loti (Mesorhizobium loti) MLR2185 protein%2C 133 aa%3B fasta scores: opt: 522 Z-score: 639.6 E(): 5.4e-28%3B 64.122%25 identity in 131 aa overlap gene gene4533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4486 SCO4487 SCO4487 pkaG pkaG 4905443 4907221 + Ser/Thr protein kinase SCD69.07%2C pkaG%2C Ser/Thr protein kinase%2C len: 592 aa%3B identical to previously sequenced TR:Q9ZN80 (EMBL:AB021679) Streptomyces coelicolor Ser/Thr protein kinase PkaG%2C 592 aa. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature gene gene4534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4487 SCO4488 SCO4488 SCD69.08 SCD69.08 4907340 4909220 + Ser/Thr protein kinase SCD69.08%2C probable Ser/Thr protein kinase%2C len: 626 aa%3B similar to TR:Q9XAI1 (EMBL:AL079348) Streptomyces coelicolor Ser/Thr protein kinase SC66T3.32c%2C 783 aa%3B fasta scores: opt: 918 z-score: 575.3 E(): 1.4e-24%3B 37.6%25 identity in 558 aa overlap%2C to S. coelicolor SCD6901%2C 607 aa%3B fasta scores: opt: 2094 z-score: 1205.1 E(): 0%3B 59.6%25 identity in 614 aa overlap and to TR:Q9ZN80 (EMBL:AB021679) Streptomyces coelicolor Ser/Thr protein kinase PkaG%2C 592 aa%3B fasta scores: opt: 810 z-score: 475.9 E(): 5.8e-21%3B 32.1%25 identity in 595 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and match to Prosite entry PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature. Contains also a possible hydrophobic membrane spanning region gene gene4535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4488 SCO4489 SCO4489 SCD69.09c SCD69.09c 4909224 4909526 - hypothetical protein SCD69.09c%2C membrane protein%2C len: 100 aa. Contains possible hydrophobic membrane spanning regions gene gene4536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4489 SCO4490 SCO4490 SCD69.10 SCD69.10 4909614 4911071 + decarboxylase SCD69.10%2C decarboxylase%2C len: 485 aa%3B similar to SW:Y209_ARCFU (EMBL:AE001091) Archaeoglobus fulgidus hypothetical protein AF0209%2C 481 aa%3B fasta scores: opt: 1557 z-score: 1800.8 E(): 0%3B 48.6%25 identity in 484 aa overlap and to SW:P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores%3B opt: 1293%2C Z-score: 1478.5%2C 40.162%25 identity (41.336%25 ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096%2C Protein of unknown function. gene gene4537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4490 SCO4491 SCO4491 ubiA ubiA 4911068 4911973 + 4-hydroxybenzoate octaprenyltransferase UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones%2C hemes%2C chlorophylls%2C vitamin E%2C and shikonin gene gene4538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4491 SCO4492 SCO4492 SCD69.12 SCD69.12 4912029 4912679 + octaprenyl carboxylase SCD69.12%2C probable octaprenyl carboxylase%2C len: 216 aa%3B similar to TR:P72743 (EMBL:D90900) Synechocystis sp. 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX%2C 206 aa%3B fasta scores: opt: 446 z-score: 524.1 E(): 9.9e-22%3B 40.3%25 identity in 211 aa overlap and to SW:UBIX_ECOLI (EMBL:M68935) Escherichia coli 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX%2C 189 aa%3B fasta scores: opt: 306 z-score: 363.7 E(): 8.5e-13%3B 38.2%25 identity in 207 aa overlap gene gene4539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4492 SCO4493 SCO4493 SCD69.13 SCD69.13 4912701 4913204 + transcription regulator AsnC SCD69.13%2C probable asnC-family transcriptional regulator%2C len: 167 aa%3B similar to SW:LRPC_BACSU (EMBL:AB001488) Bacillus subtilis transcriptional regulator LrpC%2C 144 aa%3B fasta scores: opt: 249 z-score: 304.8 E(): 1.6e-09%3B 36.0%25 identity in 125 aa overlap. Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family and match to Prosite entry PS00519 Bacterial regulatory proteins%2C asnC family signature. Contains a possible helix-turn-helix motif at residues 33..45 (+2.79 SD) and also a TTA leucine codon%2C possible target for bldA regulation gene gene4540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4493 SCO4494 SCO4494 SCD35.01 SCD35.01 4913249 4914412 + hypothetical protein SCD35.01%2C unknown%2C len: >95 aa~SCD69.14%2C conserved hypothetical protein (fragment)%2C len: >358 aa%3B similar to TR:AAF09948 (EMBL:AE001897) Deinococcus radiodurans conserved hypothetical protein DR0366%2C 376 aa%3B fasta scores: opt: 896 z-score: 1100.7 E(): 0%3B 39.8%25 identity in 357 aa overlap gene gene4541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4494 SCO4495 SCO4495 SCD35.02 SCD35.02 4914637 4915275 + DNA polymerase-like protein SCD35.02%2C possible DNA polymerase related protein%2C len: 212 aa%3B similar to TR:AAF11304 (EMBL:AE002016) Deinococcus radiodurans DNA polymerase-related protein DR1751%2C 237 aa%3B fasta scores: opt: 380 z-score: 451.4 E(): 1e-1%3B 41.5%25 identity in 188 aa overlap and to N-terminal region of SW:DPOL_BPSP1 (EMBL:M84415) Bacteriophage SP01 DNA polymerase (EC 2.7.7.7) 31%2C 924 aa%3B fasta scores: opt: 191 z-score: 223.4 E(): 5.2e-05%3B 33.7%25 identity in 169 aa overlap gene gene4542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4495 SCO4496 SCO4496 SCD35.03 SCD35.03 4915292 4915816 + acetyltransferase SCD35.03%2C possible acetyltransferase%2C len: 174 aa%3B similar to TR:CAB71250 (EMBL:AL138598) Streptomyces coelicolor acetyltransferase SC1A2.12%2C 181 aa%3B fasta scores: opt: 214 z-score: 278.1 E(): 4.6e-08%3B 32.9%25 identity in 149 aa overlap and to SW:TTR_PSESY (EMBL:X17150) Pseudomonas syringae (pv. syringae) acetyltransferase (EC 2.3.1.-) Ttr%2C 17 aa%3B fasta scores: opt: 137 z-score: 182.0 E(): 0.01%3B 28.3%25 identity in 138 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene4543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4496 SCO4497 SCO4497 SCD35.04 SCD35.04 4915937 4916236 + hypothetical protein SCD35.04%2C possible membrane protein%2C len: 297 aa. Contains possible hydrophobic membrane spanning regions gene gene4544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4497 SCO4498 SCO4498 SCD35.05 SCD35.05 4916551 4917873 + proton transport protein SCD35.05%2C probable proton transport protein%2C len: 440 aa%3B similar to TR:Q54104 (EMBL:X92556) Saccharopolyspora erythraea similar to GltP glutamate transporters HgtA%2C 449 aa%3B fasta scores: opt: 1339 z-score: 1482.7 E(): 0%3B 50.2%25 identity in 422 aa overlap and to SW:GLTP_BACSU (EMBL:U15147) Bacillus subtilis proton glutamate symport protein (glutamate-aspartate carrier protein) GltP%2C 414 aa%3B fasta scores: opt: 684 z-score: 760.6 E(): 0%3B 28.9%25 identity in 409 aa overlap. Contains Pfam match to entry PF00375 SDF%2C Sodium:dicarboxylate symporter family and possible hydrophobic membrane spanning regions gene gene4545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4498 SCO4499 SCO4499 SCD35.06 SCD35.06 4917934 4918656 + TetR family transcriptional regulator SCD35.06%2C probable tetR-family regulatory protein%2C len: 240 aa%3B similar to TR:O53661 (EMBL:AL021929) Mycobacterium tuberculosis regulatory protein MTV034.04%2C 204 aa%3B fast scores: opt: 447 z-score: 507.8 E(): 7.5e-21%3B 41.4%25 identity in 198 aa overlap and to SW:MTRR_NEIGO (EMBL:Z25797) Neisseria gonorrhoeae regulatory protien MtrR%2C 210 aa%3B fasta scores: opt: 164 z-score: 193.8 E(): 0.0023%3B 28.3%25 identity in 159 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 34..55 (+3.38 SD) gene gene4546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4499 SCO4500 SCO4500 SCD35.07c SCD35.07c 4919005 4919880 - dehydratase SCD35.07c%2C possible dehydratase%2C len: 291 aa%3B similar to TR:Q04846 (EMBL:X64795) Corynebacterium ammoniagenes fatty acid synthase (EC 2.3.1.85)%2C Fas%2C 3104 aa%2C 3-hydroxydecanoyl beta%2C gamma-dehydratase domain (315 aa)%3B fasta scores: opt: 155 z-score: 164.5 E(): 0.098%3B 26.9%25 identity in 264 aa overlap. Contains Pfam match to entry PF01575 MaoC_like%2C MaoC like domain gene gene4547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4500 SCO4501 SCO4501 fabG fabG 4919880 4921172 - 3-ketoacyl-ACP reductase Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis gene gene4548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4501 SCO4502 SCO4502 SCD35.09 SCD35.09 4921335 4922621 + acetyl-CoA acetyltransferase Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase%2C catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation gene gene4549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4502 SCO4503 SCO4503 SCD35.10 SCD35.10 4923031 4924959 + long-chain-fatty acid CoA ligase SCD35.10%2C probable long-chain-fatty acid CoA ligase%2C len: 642 aa%3B similar to TR:Q9ZBW6 (EMBL:AL034443) Streptomyces coelicolor long-chain-fatty acid CoA ligase SC4B5.02c%2C 608 aa%3B fasta scores: opt: 2125 z-score: 2339.4 E(): 0%3B 53.0%25 identity in 610 aa overlap and to SW:LCFE_RAT (EMBL:AB012933) Rattus norvegicus long-chain-fatty acid CoA ligase 5 (EC 6.2.1.3) FacL5%2C 683 aa%3B fasta scores: opt: 488 z-score: 536.4 E(): 1.9e-22%3B 27.3%25 identity in 607 aa overlap. Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and match to Prosite entry PS00455 AMP-binding domain signature gene gene4550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4503 SCO4504 SCO4504 SCD35.11c SCD35.11c 4924984 4925628 - methyltransferase SCD35.11c%2C possible methyltransferase%2C len: 241 aa%3B similar to TR:CAB61165 (EMBL:AL132973) Streptomyces coelicolor methyltransferase SCF91.08%2C 231 aa%3B fasta scores: opt: 214 z-score: 264.5 E(): 2.7e-07%3B 29.1%25 identity in 206 aa overlap and to SW:BIOC_SERMA (EMBL:D17468) Serratia marcescens biotin synthesis protein BioC%2C 255 aa%3B fasta scores: opt: 179 z-score: 222.0 E(): 6.2e-05%3B 34.0%25 identity in 100 aa overlap gene gene4551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4504 SCO4505 SCO4505 SCD35.12c SCD35.12c 4925750 4925953 - cold shock protein SCD35.12c%2C scoF2%2C cold shock protein%2C len: 67 aa%3B highly similar to SW:CSP7_STRCL (EMBL:X68245) Streptomyces clavuligerus cold shock-like protein 7.0 SC7.0%2C 66 aa%3B fasta scores: opt: 389 z-score: 532.0 E(): 3.3e-22%3B 87.9%25 identity in 66 aa overlap and to SW:CSPF_STRCO (EMBL:X92686) Streptomyces coelicolor cold shock protein ScoF%2C 67 aa%3B fasta scores: opt: 384 z-score: 525.4 E(): 7.8e-22%3B 78.8%25 identity in 66 aa overlap. Contains PS00352 'Cold-shock' DNA-binding domain signature gene gene4552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4505 SCO4506 SCO4506 SCD35.13 SCD35.13 4926246 4927094 + hypothetical protein SCD35.13%2C conserved hypothetical protein%2C len: 282 aa%3B similar to various hypothetical proteins e.g. TR:P94301 (EMBL:U61168) Bacillus firmus hypothetical 32.2 kD protein%2C 281 aa%3B fasta scores: opt: 398 z-score: 495.8 E(): 3.5e-20%3B 31.1%25 identity in 244 aa overlap gene gene4553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4506 SCO4507 SCO4507 SCD35.14 SCD35.14 4927170 4928930 + Ser/Thr protein kinase SCD35.14%2C probable Ser/Thr protein kinase%2C len: 568 aa%3B similar to TR:Q9XAI1 (EMBL:AL079348) Streptomyces coelicolor Ser/Thr protein kinase SC66T3.32c%2C 783 aa%3B fasta scores: opt: 1187 z-score: 836.4 E(): 0%3B 46.3%25 identity in 510 aa overlap and to SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor Ser/Thr protein kinase AfsK (EC 2.7.1.-)%2C 799 aa%3B fasta scores: opt: 662 z-score: 472.7 E(): 6.7e-19%3B 41.8%25 identity in 481 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature gene gene4554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4507 SCO4508 SCO4508 SCD35.15c SCD35.15c 4928991 4933568 - cell division-like protein SCD35.15%2C possible cell division-related protein%2C len: 1525 aa%3B similar to TR:P71068 (EMBL:Z99120) Bacillus subtilis YukA protein%2C 1207 aa%3B fasta scores: opt: 682 z-score: 717.6 E(): 1.5e-32%3B 23.7%25 identity in 1288 aa overlap and C-terminal region similar to TR:O25722 (EMBL:AE000615) Helicobacter pylori (Campylobacter pylori) cell division protein (FtsK)%2C 858 aa%3B fasta scores: opt: 347 z-score: 364.2 E(): 7.4e-13%3B 33.1%25 identity in 245 aa overlap. Contains two Pfam matches to entry PF01580 FtsK_SpoIIIE%2C FtsK/SpoIIIE family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible hydrophobic membrane spanning region gene gene4555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4508 SCO4509 SCO4509 SCD35.16 SCD35.16 4933782 4934156 + hypothetical protein SCD35.16%2C unknown%2C len: 124 aa. Contains possible coiled-coil region at aprox. residues 40..56 gene gene4556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4509 SCO4510 SCO4510 SCD35.17c SCD35.17c 4934190 4934597 - hypothetical protein SCD35.17c%2C unknown%2C len: 135 aa gene gene4557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4510 SCO4511 SCO4511 SCD35.18c SCD35.18c 4934688 4935107 - hypothetical protein SCD35.18c%2C possible integral membrane protein%2C len: 139 aa. Contains possible hydrophobic membrane spanning region gene gene4558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4511 SCO4512 SCO4512 SCD35.19c SCD35.19c 4935104 4935685 - hypothetical protein SCD35.19c%2C unknown%2C len: 193 aa gene gene4559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4512 SCO4513 SCO4513 SCD35.20c SCD35.20c 4935682 4936350 - hypothetical protein SCD35.20c%2C unknown%2C len: 222 aa gene gene4560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4513 SCO4514 SCO4514 SCD35.21c SCD35.21c 4936347 4936925 - hypothetical protein SCD35.21c%2C possible integral membrane protein%2C len: 192 aa. Contains possible hydrophobic membrane spanning regions gene gene4561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4514 SCO4515 SCO4515 SCD35.22c SCD35.22c 4936959 4938164 - hypothetical protein SCD35.22c%2C hypothetical protein%2C len: 401 aa%3B similar to TR:Q9XD98 (EMBL:AF106004) Streptomyces coelicolor hypothetical 27.5 kD protein%2C 249 aa%3B fasta scores: opt: 190 z-score: 190.8 E(): 0.0034%3B 26.8%25 identity in 190 aa overlap and to TR:Q9F3G6 (EMBL:AL392175) Streptomyces coelicolor membrane protein 2SCD4.05%2C 474 aa%3B fasta scores: opt: 583 Z-score: 556.4 E(): 2.3e-23%3B 36.422%25 identity in 313 aa overlap. Contains possible hydrophobic membrane spanning regions and also possible colied-coil region ar aprox. residues 104..127 gene gene4562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4515 SCO4516 SCO4516 SCD35.23c SCD35.23c 4938161 4938520 - hypothetical protein SCD35.23c%2C unknown%2C len: 119 aa gene gene4563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4516 SCO4517 SCO4517 SCD35.24c SCD35.24c 4938790 4939515 - hypothetical protein SCD35.24c%2C hypothetical protein%2C len: 241 aa%3B C-terminal region similar to TR:Q9KYA0 (EMBL:AL356813) Streptomyces coelicolor conserved hypothetical protein SCK15.04c%2C 216 aa%3B fasta scores: opt: 613 Z-score: 714.3 E(): 3.8e-32%3B 52.792%25 identity in 197 aa overlap gene gene4564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4517 SCO4518 SCO4518 SCD35.25c SCD35.25c 4939512 4940861 - hypothetical protein SCD35.25c%2C possible integral membrane protein%2C len: 449 aa. Contains possible hydrophobic membrane spanning regions and possible colied-coil region at aprox. residues 82..110 gene gene4565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4518 SCO4519 SCO4519 SCD35.26 SCD35.26 4940966 4941562 + hypothetical protein SCD35.26%2C possible integral membrane protein%2C len: 198 aa%3B similar to TR:Q9KYA1 (EMBL:AL356813) integral membrane protein SCK15.03 from Streptomyces coelicolor (213 aa) fasta scores%3B opt: 349%2C Z-score: 400.7%2C E(): 1.1e-14%2C 37.363%25 identity (37.989%25 ungapped) in 182 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4519 SCO4520 SCO4520 SCD35.27c SCD35.27c 4941567 4941872 - hypothetical protein SCD35.27c%2C hypothetical protein%2C len: 101 aa%3B similar to TR:Q9KYA2 (EMBL:AL356813) Streptomyces coelicolor conserved hypothetical protein SCK15.02%2C 102 aa%3B fasta scores: opt: 471 Z-score: 568.2 E(): 5.2e-24%3B 73.684%25 identity in 95 aa overlap gene gene4567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4520 SCO4521 SCO4521 SCD35.28c SCD35.28c 4941895 4942980 - hypothetical protein SCD35.28c%2C possible hypothetical protein%2C len: 361 aa%3B similar to TR:Q9F3F6 (EMBL:AL392175) Streptomyces coelicolor hypothetical protein 2SCD4.18%2C 355 aa%3B fasta scores: opt: 942 Z-score: 1049.8 E(): 7.7e-51%3B 43.296%25 identity. Contains possible N-terminal region signal peptide sequence gene gene4568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4521 SCO4522 SCO4522 SCD35.29c SCD35.29c 4942977 4943453 - hypothetical protein SCD35.29c%2C unknown%2C len: 158 aa gene gene4569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4522 SCO4523 SCO4523 SCD35.30 SCD35.30 4943703 4944296 + hypothetical protein SCD35.30%2C possible integral membrane protein%2C len: 197 aa. Contains possible hydrophobic membrane spanning regions gene gene4570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4523 SCO4524 SCO4524 SCD35.31 SCD35.31 4945126 4945845 + hypothetical protein SCD35.31%2C membrane protein%2C len: 239 aa. Contains possible hydrophobic membrane spanning region gene gene4571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4524 SCO4525 SCO4525 SCD35.32 SCD35.32 4945864 4946745 + hypothetical protein SCD35.32%2C unknown%2C len: 293 aa. Contains match to Prosite entry PS00038 Myc-type%2C 'helix-loop-helix' dimerization domain signature gene gene4572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4525 SCO4526 SCO4526 SCD35.33 SCD35.33 4946742 4948049 + protein kinase SCD35.33%2C possible protein kinase%2C len: 435 aa%3B similar to TR:P94647 (EMBL:U77780) Chlorobium limicola secretory protein kinase Kbh%2C 474 aa%3B fasta scores: opt: 722 z-score: 805.0 E(): 0%3B 35.9%25 identity in 368 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4526 SCO4527 SCO4527 SCD35.34 SCD35.34 4948063 4949100 + hypothetical protein SCD35.34%2C possible integral membrane protein%2C len: 345 aa. Contains possible hydrophobic membrane spanning regions gene gene4574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4527 SCO4528 SCO4528 SCD35.35 SCD35.35 4949109 4950017 + hypothetical protein SCD35.35%2C possible integral membrane protein%2C len: 302 aa. Contains possible hydrophobic membrane spanning regions gene gene4575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4528 SCO4529 SCO4529 SCD35.36 SCD35.36 4950014 4950367 + hypothetical protein SCD35.36%2C possible integral membrane protein%2C len: 117 aa. Contains possible hydrophobic membrane spanning regions gene gene4576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4529 SCO4530 SCO4530 2SCD4.01 2SCD4.01 4950395 4950955 + hypothetical protein 2SCD4.01%2C possible membrane protein (fragment)%2C len: >147 aa. Contains possible hydrophobic membrane spanning region~SCD35.37%2C unknown%2C len: >77 aa gene gene4577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4530 SCO4531 SCO4531 2SCD4.02 2SCD4.02 4950956 4951393 + septum determining protein 2SCD4.02%2C possible septum determining protein%2C len: 145 aa%3B similar to TR:CAB92601 (EMBL:AL356813) Streptomyces coelicolor septum determining protein MinD3%2C 131 aa%3B fasta scores: opt: 115 z-score: 155.7 E(): 0.33%3B 30.7%25 identity in 137 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4531 SCO4532 SCO4532 2SCD4.03 2SCD4.03 4951390 4951851 + hypothetical protein 2SCD4.03%2C possible membrane protein%2C len: 153 aa. Contains possible hydrophobic membrane spanning region gene gene4579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4532 SCO4533 SCO4533 2SCD4.04 2SCD4.04 4951930 4952256 + hypothetical protein 2SCD4.04%2C hypothetical protein%2C len: 108 aa%3B similar to TR:CAB77307 (EMBL:AL160312) Streptomyces coelicolor hypothetical 13.8 kDa protein SCD35.23c%2C 119 aa%3B fasta scores: opt: 290 z-score: 364.1 E(): 8.2e-13%3B 47.6%25 identity in 105 aa overlap gene gene4580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4533 SCO4534 SCO4534 2SCD4.05 2SCD4.05 4952253 4953677 + hypothetical protein 2SCD4.05%2C possible membrane protein%2C len: 474 aa%3B similar to TR:CAB77306 (EMBL:AL160312) Streptomyces coelicolor hypothetical 42.7 kDa protein SCD35.22c%2C 401 aa%3B fasta scores: opt: 583 z-score: 575.3 E(): 1.4e-24%3B 36.4%25 identity in 313 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4534 SCO4535 SCO4535 2SCD4.06 2SCD4.06 4953674 4955002 + hypothetical protein 2SCD4.06%2C possible integral membrane protein%2C len: 442 aa. Contains possible hydrophobic membrane spanning regions gene gene4582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4535 SCO4536 SCO4536 2SCD4.07 2SCD4.07 4954999 4955643 + hypothetical protein 2SCD4.07%2C hypothetical protein%2C len: 214 aa%3B similar to TR:CAB77303 (EMBL:AL160312) Streptomyces coelicolor hypothetical 21.2 kDa protein SCD35.19c%2C 193 aa%3B fasta scores: opt: 228 z-score: 264.4 E(): 2.9e-07%3B 31.1%25 identity in 212 aa overlap gene gene4583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4536 SCO4537 SCO4537 2SCD4.08 2SCD4.08 4955640 4956245 + hypothetical protein 2SCD4.08%2C unknown%2C len: 201 aa gene gene4584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4537 SCO4538 SCO4538 2SCD4.09c 2SCD4.09c 4956301 4956636 - hypothetical protein 2SCD4.09c%2C unknown%2C len: 111 aa. High content in aspartic acid%2C leucine and lysine amino acid residues. Highly hydrophilic gene gene4585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4538 SCO4539 SCO4539 2SCD4.10c 2SCD4.10c 4956659 4957264 - hypothetical protein 2SCD4.10c%2C hypothetical protein%2C len: 201 aa%3B highly similar to TR:CAB82060 (EMBL:AL161803) Streptomyces coelicolor hypothetical 23.3 kDa protein SCD31.17%2C 215 aa%3B fasta scores: opt: 776 z-score: 926.5 E(): 0%3B 59.0%25 identity in 200 aa overlap gene gene4586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4539 SCO4540 SCO4540 2SCD4.11c 2SCD4.11c 4957302 4957544 - hypothetical protein 2SCD4.11c%2C unknown%2C len: 80 aa. Low G+C content (56.25%25) gene gene4587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4540 SCO4541 SCO4541 2SCD4.12c 2SCD4.12c 4957723 4959303 - hypothetical protein 2SCD4.12c%2C possible membrane protein%2C len: 526 aa%3B N-terminal region identical to previously sequenced TR:Q9XD98 (EMBL:AF106004) Streptomyces coelicolor hypothetical 27.5 kDa protein%2C 249 aa and to TR:CAB82065 (EMBL:AL161803) Streptomyces coelicolor integral membrane protein SCD31.22%2C 604 aa%3B fasta scores: opt: 1299 z-score: 1315.4 E(): 0%3B 57.8%25 identity in 339 aa overlap. Contains possible coiled-coil region at approx. residues 108..198 and possible hydrophobic membrane spanning region gene gene4588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4541 SCO4542 SCO4542 2SCD4.13c 2SCD4.13c 4959382 4959573 - hypothetical protein 2SCD4.13c%2C hypothetical protein%2C len: 63 aa%3B identical to previously sequenced TR:Q9XD97 (EMBL:AF106004) Streptomyces coelicolor BldB homolog hypothetical 6.8 kDa protein%2C 63 aa and to TR:Q9RDI7 (EMBL:AL136519) Streptomyces coelicolor hypothetical 7.1 kDa protein SCC57A.10c%2C 65 aa%3B fasta scores: opt: 237 z-score: 357.1 E(): 2e-12%3B 64.8%25 identity in 54 aa overlap gene gene4589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4542 SCO4543 SCO4543 2SCD4.14c 2SCD4.14c 4959584 4960435 - hypothetical protein 2SCD4.14c%2C hypothetical protein%2C len: 283 aa%3B identical to previously sequenced TR:Q9XD96 (EMBL:AF106004) Streptomyces coelicolor hypothetical 31.8 kDa protein%2C 283 aa gene gene4590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4543 SCO4544 SCO4544 2SCD4.15 2SCD4.15 4960649 4961074 + hypothetical protein 2SCD4.15%2C hypothetical protein%2C len: 141 aa%3B identical to previously sequenced TR:Q9XD95 (EMBL:AF106004) Streptomyces coelicolor hypothetical 15.4 kDa protein%2C 141 aa gene gene4591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4544 SCO4545 SCO4545 2SCD4.16 2SCD4.16 4961108 4962022 + hypothetical protein 2SCD4.16%2C hypothetical protein%2C len: 304 aa%3B identical to previously sequenced TR:Q9XD94 (EMBL:AF106004) Streptomyces coelicolor hypothetical 34.1 kDa protein%2C 304 aa and highly similar to TR:CAB81866 (EMBL:AL161691) Streptomyces coelicolor hypothetical protein SCD40A.21c%2C 302 aa%3B fasta scores: opt: 850 z-score: 894.4 E(): 0%3B 45.0%25 identity in 300 aa overlap gene gene4592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4545 SCO4546 SCO4546 2SCD4.17 2SCD4.17 4962128 4962778 + lipoprotein 2SCD4.17%2C possible lipoprotein%2C len: 216 aa%3B similar to TR:CAB92614 (EMBL:AL356813) Streptomyces coelicolor lipoprotein SCK15.23%2C 221 aa%3B fasta scores: opt: 525 z-score: 595.2 E(): 1.1e-25%3B 39.4%25 identity in 213 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal peptide sequence gene gene4593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4546 SCO4547 SCO4547 2SCD4.18 2SCD4.18 4962778 4963845 + hypothetical protein 2SCD4.18%2C possible hypothetical protein%2C len: 355 aa%3B similar to TR:CAB77312 (EMBL:AL160312) Streptomyces coelicolor hypothetical protein SCD35.28c%2C 361 aa%3B fasta scores: opt: 942 z-score: 949.2 E(): 0%3B 43.9%25 identity in 360 aa overlap. Contains possible N-terminal signal peptide sequence gene gene4594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4547 SCO4548 SCO4548 2SCD4.19 2SCD4.19 4964061 4967069 + hypothetical protein SCD16A.35c%2C partial CDS%2C unknown%2C len: >726 aa~2SCD4.19%2C possible integral membrane protein (fragment)%2C len: >309 aa. Contains possible hydrophobic membrane spanning regions gene gene4595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4548 SCO4549 SCO4549 SCD16A.34c SCD16A.34c 4967066 4967845 + type IV peptidase SCD16A.34c%2C possible type IV peptidase%2C len: 259aa%3B similar to many eg. SW:LEP3_PSEAE type IV prepilin peptidase from Pseudomonas aeruginosa (290 aa) fasta scores%3B opt: 304%2C z-score: 344.8%2C E(): 7e-12%2C (32.5%25 identity in 228 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene4596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4549 SCO4550 SCO4550 SCD16A.33c SCD16A.33c 4967924 4969123 + hypothetical protein SCD16A.33c%2C conserved hypothetical protein%2C len: 399 aa%3B similar to many e.g. TR:O25370 (EMBL:AE000579) conserved hypothetical protein from Helicobacter pylori (383 aa) fasta scores%3B opt: 1039%2C z-score: 1256.5%2C E(): 0%2C (44.5%25 identity in 357 aa overlap). gene gene4597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4550 SCO4551 SCO4551 SCD16A.32c SCD16A.32c 4969131 4969730 + hypothetical protein SCD16A.32c%2C unknown%2C len: 199 aa%3B similar to SW:YXP2_XANCP hypothetical protein from Xanthonomas campestris (257 aa) fasta scores%3B opt: 119%2C z-score: 138.0%2C E(): 2.3%2C (31.1%25 identity in 167 aa overlap). gene gene4598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4551 SCO4552 SCO4552 SCD16A.31 SCD16A.31 4969766 4970770 - hydrolase SCD16A.31%2C possible hydrolase%2C len: 334aa%3B similar to eg. TR:Q59145 (EMBL:D31818) chitinases II precursor from Aeromonas sp. NO.10S-24 (542 aa) fasta scores%3B opt: 482%2C z-score: 492.4%2C E(): 4.2e-20%2C (36.6%25 identity in 273 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene4599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4552 SCO4553 SCO4553 SCD16A.30c SCD16A.30c 4970964 4971383 + hypothetical protein SCD16A.30c%2C membrane protein%2C len: 139 aa. Contains possible hydrophobic membrane spanning regions gene gene4600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4553 SCO4554 SCO4554 SCD16A.29c SCD16A.29c 4971401 4973632 + bifunctional transferase/deacetylase SCD16A.29c%2C possible bi-functional transferase/deacetylase%2C len: 743aa%3B 380-620aa region similar to TR:BAA35803 (EMBL:D90739) glycosyl transferase from Escherichia coli (441 aa) fasta scores%3B opt: 518%2C z-score: 576.7%2C E(): 8.6e-25%2C (35.4%25 identity in 257 aa overlap). 100-290aa region similar to SW:NODB_RHIME chitooligosaccharide deactylase from Rhizobium meliloti (217 aa) fasta scores%3B opt: 398%2C z-score: 448.0%2C E(): 1.3e-17%2C (35.7%25 identity in 196 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases. Also contains possible membrane spanning hydrophobic regions. gene gene4601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4554 SCO4555 SCO4555 SCD16A.28c SCD16A.28c 4973632 4974723 + integral membrane transferase SCD16A.28c%2C possible integral membrane transferase%2C len: 363aa%3B similar to TR:Q56803 (EMBL:X78451) O-acetyl transferase from Xanthomonas campestris (364 aa) fasta scores%3B opt: 123%2C z-score: 149.6%2C E(): 0.53%2C (26.2%25 identity in 378 aa overlap). Contains possible membrane spanning hydrophobic regions. gene gene4602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4555 SCO4556 SCO4556 ubiE ubiE 4974767 4975462 + ubiquinone/menaquinone biosynthesis methyltransferase Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone gene gene4603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4556 SCO4557 SCO4557 SCD16A.26 SCD16A.26 4975449 4975796 - hypothetical protein SCD16A.26%2C unknown%2C len: 115aa gene gene4604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4557 SCO4558 SCO4558 SCD16A.25 SCD16A.25 4975855 4976418 - acetyltransferase SCD16A.25%2C possible acetyltransferase%2C len: 187 aa%3B similar to SW:YKKB_BACSU hypothetical protein from Bacillus subtilis (172 aa) fasta scores%3B opt: 237%2C z-score: 294.8%2C E(): 4.3e-09%2C (30.8%25 identity in 146 aa overlap). Also similar to the N-terminal half of TR:Q53796 (EMBL:L26955) bleomycin acetyltransferase from the bleomycin-resistance region of Streptomyces verticillus (301 aa) fasta scores%3B opt: 163%2C z-score: 203.0%2C E(): 0.00056%2C (33.5%25 identity in 155 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene4605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4558 SCO4559 SCO4559 SCD16A.24c SCD16A.24c 4976516 4977808 + electron transfer oxidoreductase SCD16A.24c%2C possible electron transfer oxidoreductase%2C len: 430a a%3B similar to many e.g. TR:O06427 (EMBL:Z95558) hypothetical protein from Mycobacterium tuberculosis (408 aa) fasta scores%3B opt: 449%2C z-score: 501.6%2C E(): 1.3e-20%2C (34.6%25 identity in 416 aa overlap) and SW:FIXC_ECOLI probable electron transfer oxidoreductase FixC from Escherichia coli (428 aa) fasta scores%3B opt: 277%2C z-score: 311.0%2C E(): 5.4e-10%2C (27.0%25 identity in 367 aa overlap). gene gene4606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4559 SCO4560 SCO4560 SCD16A.23 SCD16A.23 4977869 4978495 - polypetide deformylase SCD16A.23%2C possible polypetide deformylase%2C len: 208aa%3B similar to many eg. TR:P96275 (EMBL:Z84724) hypothetical protein from Mycobacterium tuberculosis (197 aa) fasta scores%3B opt: 425%2C z-score: 513.1%2C E(): 3e-21%2C (48.0%25 identity in 171 aa overlap) and SW:DEF_ECOLI polypetide deformylase from Escherichia coli (168 aa) fasta scores%3B opt: 373%2C z-score: 452.6%2C E(): 7e-18%2C (35.6%25 identity in 174 aa overlap). Contains Pfam match to entry PF01327 Pep_deformylase%2C Polypeptide deformylase. gene gene4607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4560 SCO4561 SCO4561 SCD16A.22 SCD16A.22 4978629 4979462 - hypothetical protein SCD16A.22%2C possible hypothetical protein%2C len: 277aa%3B similar to many eg. TR:CAB39862 (EMBL:AL049497) hypothetical protein from Streptomyces coelicolor (338 aa) fasta scores%3B opt: 386%2C z-score: 364.3%2C E(): 5.8e-13%2C (35.1%25 identity in 251 aa overlap) and the C-terminal half of many Listeria spp. extracellular proteins eg. SW:P60_LISIN P60 Listeria innocua (481 aa) fasta scores%3B opt: %2C z-score: 328.5%2C E(): 5.7e-11%2C (28.9%25 identity in 242 aa overlap). Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family. Also contains coiled-coil region at 92-125aa and possible hydrophobic membrane spanning region gene gene4608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4561 SCO4562 SCO4562 nuoA nuoA 4980274 4980633 + NADH dehydrogenase subunit A Catalyzes the transfer of electrons from NADH to quinone gene gene4609 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4562 SCO4563 SCO4563 nuoB nuoB 4980646 4981200 + NADH dehydrogenase subunit B The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen gene gene4610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4563 SCO4564 SCO4564 nuoC nuoC 4981197 4981952 + NADH dehydrogenase subunit C Catalyzes the transfer of electrons from NADH to quinone gene gene4611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4564 SCO4565 SCO4565 nuoD nuoD 4981949 4983271 + NADH dehydrogenase subunit D Catalyzes the transfer of electrons from NADH to quinone gene gene4612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4565 SCO4566 SCO4566 nuoE nuoE 4983268 4984140 + NADH dehydrogenase subunit E Catalyzes the transfer of electrons from NADH to quinone gene gene4613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4566 SCO4567 SCO4567 nuoF nuoF 4984137 4985486 + NADH dehydrogenase subunit NuoF SCD16A.16c%2C nuoF%2C NADH dehydrogenase subunit%2C len: 449 aa%3B similar to many e.g. TR:P95176 (EMBL:Z83867) NuoF%2C NADH dehydrogenase subunit from Mycobacterium tuberculosis (445 aa) fasta scores%3B opt: 2314%2C z-score: 2659.4%2C E(): 0%2C (76.3%25 identity in 434 aa overlap) and SW:NUOF_ECOLI%2C NADH dehydrogenase subunit NuoF from Escherichia coli (445 aa) fasta scores%3B opt: 1346%2C z-score: 1547.8%2C E(): 0%2C (48.1%25 identity in 405 aa overlap). Contains Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. gene gene4614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4567 SCO4568 SCO4568 nuoG nuoG 4985483 4988014 + NADH dehydrogenase subunit G Catalyzes the transfer of electrons from NADH to quinone gene gene4615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4568 SCO4569 SCO4569 nuoH nuoH 4988011 4989414 + NADH dehydrogenase subunit H Catalyzes the transfer of electrons from NADH to quinone gene gene4616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4569 SCO4570 SCO4570 nuoI nuoI 4989449 4990084 + NADH dehydrogenase subunit I Catalyzes the transfer of electrons from NADH to quinone gene gene4617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4570 SCO4571 SCO4571 nuoJ nuoJ 4990081 4990938 + NADH dehydrogenase subunit J Catalyzes the transfer of electrons from NADH to quinone gene gene4618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4571 SCO4572 SCO4572 nuoK nuoK 4990935 4991234 + NADH dehydrogenase subunit K Catalyzes the transfer of electrons from NADH to quinone gene gene4619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4572 SCO4573 SCO4573 nuoL nuoL 4991249 4993213 + NADH dehydrogenase subunit L Catalyzes the transfer of electrons from NADH to ubiquinone gene gene4620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4573 SCO4574 SCO4574 nuoM nuoM 4993219 4994790 + NADH dehydrogenase subunit M Catalyzes the transfer of electrons from NADH to quinone gene gene4621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4574 SCO4575 SCO4575 nuoN nuoN 4994787 4996445 + NADH dehydrogenase subunit N Catalyzes the transfer of electrons from NADH to quinone gene gene4622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4575 SCO4576 SCO4576 SCD16A.07 SCD16A.07 4996565 4997164 - hypothetical protein SCD16A.07%2C unknown%2C len: 199 aa%3B weakly similar to others eg. TR:Q55360 (EMBL:D64003) hypothetical protein from Synechocystis sp. strain PCC6803 (190 aa) fasta scores%3B opt: 168%2C z-score: 209.8%2C E(): 0.00023%2C (26.6%25 identity in 177 aa overlap). gene gene4623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4576 SCO4577 SCO4577 SCD16A.06c SCD16A.06c 4997397 4999427 + helicase SCD16A.06c%2C probable helicase%2C len: 676aa%3B similar to many (both prokaryote and eukaryote) egs. TR:AAD05424 (EMBL:AF047374) RecQ helicase from Neisseria gonorrhoeae (767 aa) fasta scores%3B opt: 1809%2C z-score: 1769.1%2C E(): 0%2C (50.4%25 identity in 601 aa overlap) and SW:HUS2_SCHPO ATP-dependent helicase from Schizosaccharomyces pombe (1328 aa) fasta scores%3B opt: 1013%2C z-score: 988.7%2C E(): 0%2C (40.2%25 identity in 493 aa overlap). Contains Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain%2C score 78.40%2C E-value 1.4e-19. gene gene4624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4577 SCO4578 SCO4578 SCD16A.05 SCD16A.05 4999466 4999690 - hypothetical protein SCD16A.05%2C unknown%2C len: 74aa%3B predicted based upon amino acid and codon usage. gene gene4625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4578 SCO4579 SCO4579 SCD16A.04 SCD16A.04 4999752 5000690 - hypothetical protein SCD16A.04%2C possible integral membrane protein%2C len: 312aa%3B similar to others e.g. TR:O32910 (EMBL:AL008609) hypothetical protein from Mycobacterium leprae (316 aa) fasta scores%3B opt: 405%2C z-score: 470.7%2C E(): 6.9e-19%2C (32.7%25 identity in 324 aa overlap) and TR:O86628 (EMBL:AL031155) integral membrane protein from Streptomyces coelicolor (309 aa) fasta scores%3B opt: 222%2C z-score: 261.4%2C E(): 3.1e-07%2C (31.0%25 identity in 310 aa overlap). Contains possible membrane spanning hydrophobic regions gene gene4626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4579 SCO4580 SCO4580 SCD16A.03 SCD16A.03 5000997 5002253 - fumarylacetoacetase SCD16A.03%2C probable fumarylacetoacetase%2C len: 418aa%3B similar to several from eukaryotes eg. SW:FAAA_HUMAN fumarylacetoacetase from human (419 aa) fasta scores%3B opt: 1192%2C z-score: 1370.0%2C E(): 0%2C (44.6%25 identity in 426 aa overlap). gene gene4627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4580 SCO4581 SCO4581 SCD16A.02c SCD16A.02c 5002738 5003547 + hypothetical protein SCD16A.02c%2C conserved hypothetical protein%2C len: 269aa%3B similar to many hypothetical proteins egs. TR:CAA22232 (EMBL:AL034355) (280 aa) fasta scores%3B opt: 1028%2C z-score: 1143.6%2C E(): 0%2C (61.5%25 identity in 260 aa overlap) and TR:CAA22222 (EMBL:AL034355) (305 aa) fasta scores%3B opt: 546%2C z-score: 611.4%2C E(): 1e-26%2C (40.2%25 identity in 271 aa overlap) hypothetical proteins from Streptomyces coelicolor. Also similar to SW:YIDA_ECOLI hypothetical protein from Escherichia coli (270 aa) fasta scores%3B opt: 314%2C z-score: 356.2%2C E(): 1.6e-12%2C (31.0%25 identity in 268 aa overlap). Contains Pfam match to entry PF00592 DUF3%2C Domain of Unknown Function 3%2C score 116.90%2C E-value 3.9e-31 gene gene4628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4581 SCO4582 SCO4582 SCD16A.01 SCD16A.01 5003571 5004062 - hypothetical protein SCD16A.01%2C unknown%2C len: 163 aa%3B some similarity to proteins associated with bacteriophages eg. TR:Q38352 (EMBL:L29568) ORF360 hypothetical protein from Lactobacillus delbrueckii subsp. lactis bacteriophage LL-H (360 aa) fasta scores%3B opt: 255%2C z-score: 294.2%2C E(): 4.7e-09%2C (45.5%25 identity in 101 aa overlap). Contains possible hydrophobic membrane spanning region gene gene4629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4582 SCO4583 SCO4583 SCD20.01 SCD20.01 5004917 5005927 + polyprenyl diphosphate synthase SCD20.01%2C polyprenyl diphosphate synthase%2C len: 336 aa%3B similar to SW:HEP2_BACSU (EMBL:M80245) Bacillus subtilis heptaprenyl diphosphate synthase component II (EC 2.5.1.30) HepT%2C 348 aa%3B fasta scores: opt: 586 z-score: 674.6 E(): 4.2e-30%3B 33.0%25 identity in 309 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt%2C Polyprenyl synthetases and match to Prosite entry PS00444 Polyprenyl synthetases signature 2 gene gene4630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4583 SCO4584 SCO4584 SCD20.02 SCD20.02 5006187 5007449 + hypothetical protein SCD20.02%2C possible membrane protein%2C len: 420 aa. Contains possible hydrophobic membrane spanning region gene gene4631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4584 SCO4585 SCO4585 SCD20.03 SCD20.03 5007502 5008485 + ABC transporter ATP-binding protein SCD20.03%2C probable ABC transporter ATP-binding protein%2C len: 327 aa%3B similar to SW:BCRA_BACLI (EMBL:L20573) Bacillus licheniformis bacitracin transport ATP-binding protein BcrA%2C 306 aa%3B fasta scores: opt: 636 z-score: 662.0 E(): 2.1e-29%3B 39.6%25 identity in 308 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4585 SCO4586 SCO4586 SCD20.04 SCD20.04 5008487 5009416 + ABC transporter SCD20.04%2C possible ABC transporter integral membrane protein%2C len: 309 aa%3B similar to TR:CAB75311 (EMBL:AL139164) Streptomyces coelicolor integral membrane protein SCC46.07c%2C 299 aa%3B fasta scores: opt: 412 z-score: 436.8 E(): 7.3e-17%3B 27.6%25 identity in 297 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4586 SCO4587 SCO4587 SCD20.05c SCD20.05c 5009444 5010046 - hypothetical protein SCD20.05c%2C hypothetical protein%2C len: 200 aa%3B similar to TR:P96726 (EMBL:Z92952) Bacillus subtilis hypothetical 20.5 kDa protein YwqN%2C 181 aa%3B fasta scores: opt: 357 z-score: 457.0 E(): 5.5e-18%3B 33.9%25 identity in 177 aa overlap gene gene4634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4587 SCO4588 SCO4588 SCD20.06 SCD20.06 5010182 5011708 + hypothetical protein SCD20.06%2C unknown%2C len: 508 aa gene gene4635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4588 SCO4589 SCO4589 SCD20.07c SCD20.07c 5011745 5012719 - aminopeptidase SCD20.07c%2C probable aminopeptidase (hypothetical protein)%2C len: 324 aa%3B similar to SW:APX_STRGR Streptomyces griseus aminopeptidase (EC 3.4.11.-) SgaP%2C 284 aa%3B fasta scores: opt: 1532 z-score: 1626.6 E(): 0%3B 76.8%25 identity in 276 aa overlap and to (EMBL:AL391754) Streptomyces coelicolor hydrolase SCK7.16c%2C 486 aa%3B fasta scores: opt: 980 z-score: 845.8 E(): 0%3B 52.1%25 identity in 288 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene4636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4589 SCO4590 SCO4590 SCD20.08c SCD20.08c 5012930 5013400 - hypothetical protein SCD20.08c%2C hypothetical protein%2C len: 156 aa%3B similar to TR:CAB86125 (EMBL:AL163003) Streptomyces coelicolor hypothetical 16.0 kDa protein SCC24.31c%2C 142 aa%3B fasta scores: opt: 205 z-score: 265.0 E(): 2.7e-07%3B 34.0%25 identity in 156 aa overlap gene gene4637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4590 SCO4591 SCO4591 SCD20.09 SCD20.09 5013530 5014102 + hypothetical protein SCD20.09%2C hypothetical protein%2C len: 190 aa%3B similar to TR:Q9RJT3 (EMBL:AL132707) Streptomyces coelicolor hypothetical 21.7 kDa protein SCF51.02c%2C 205 aa%3B fasta scores: opt: 325 z-score: 395.2 E(): 1.5e-14%3B 40.4%25 identity in 166 aa overlap gene gene4638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4591 SCO4592 SCO4592 SCD20.10c SCD20.10c 5014126 5015214 - hypothetical protein SCD20.10c%2C possible integral membrane protein%2C len: 362 aa%3B similar to SW:RARD_ECOLI (EMBL:L02122) Escherichia coli RarD protein%2C 296 aa%3B fasta scores: opt: 792 z-score: 820.5 E(): 0%3B 42.3%25 identity in 291 aa overlap. Contains Pfam match to entry PF00892 DUF6%2C Integral membrane protein DUF6 and possible hydrophobic membrane spanning regions gene gene4639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4592 SCO4593 SCO4593 SCD20.11c SCD20.11c 5015360 5016214 - hypothetical protein SCD20.11c%2C conserved hypothetical protein%2C len: 284 aa%3B similar to SW:YTFG_ECOLI (EMBL:U14003) Escherichia coli hypothetical 29%2C7 kDa protein in RplI-CpdB intergenic region YtfG%2C 286 aa%3B fasta scores: opt: 801 z-score: 906.2 E(): 0%3B 47.1%25 identity in 280 aa overlap gene gene4640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4593 SCO4594 SCO4594 SCD20.12c SCD20.12c 5016376 5017434 - 2-oxoglutarate ferredoxin oxidoreductase subunit beta catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin gene gene4641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4594 SCO4595 SCO4595 SCD20.13c SCD20.13c 5017427 5019364 - oxidoreductase SCD20.13c%2C probable oxidoreductase%2C len: 645 aa%3B highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor oxidoreductase alpha-subunit SCAH10.35c%2C 630 aa%3B fasta scores: opt: 4069 z-score: 4338.6 E(): 0%3B 98.7%25 identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase%2C 371 aa%3B fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22%3B 31.0%25 identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N%2C Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus) gene gene4642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4595 SCO4596 SCO4596 SCD20.14c SCD20.14c 5019699 5020370 - two-component system response regulator SCD20.14c%2C possible two-component system response regulator%2C len: 252 aa%3B similar to TR:CAB92834 (EMBL:AL356892) Streptomyces coelicolor two-component response regulator SCC8A.16c%2C 212 aa%3B fasta scores: opt: 831 z-score: 957.0 E(): 0%3B 62.7%25 identity in 217 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Also contains possible helix-turn-helix motif at residues 204..225 (+2.83 SD) gene gene4643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4596 SCO4597 SCO4597 SCD20.15c SCD20.15c 5020678 5022045 - two-component system sensor kinase SCD20.15c%2C possible two-component system sensor kinase%2C len: 455 aa%3B similar to TR:CAB81858 (EMBL:AL161691) Streptomyces coelicolor two-component sensor kinase SCD40A.13%2C 431 aa%3B fasta scores: opt: 754 z-score: 831.1 E(): 0%3B 40.2%25 identity in 433 aa overlap and to Streptomyces coelicolor two-component system sensor kinase SCD20.16c%2C 407 aa%3B fasta scores: opt: 1179 z-score: 1127.3 E(): 0%3B 57.5%25 identity in 442 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4597 SCO4598 SCO4598 SCD20.16c SCD20.16c 5022159 5023382 - two-component system sensor kinase SCD20.16c%2C possible two-component system sensor kinase%2C len: 407 aa%3B similar to TR:CAB81858 (EMBL:AL161691) Streptomyces coelicolor two-component sensor kinase SCD40A.13%2C 431 aa%3B fasta scores: opt: 659 z-score: 729.4 E(): 0%3B 37.0%25 identity in 427 aa overlap and to Streptomyces coelicolor two-component system sensor kinase SCD20.15c%2C 455 aa%3B fasta scores: opt: 1179 z-score: 1124.4 E(): 0%3B 57.2%25 identity in 442 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4598 SCO4599 SCO4599 nuoA2 nuoA2 5023578 5024018 + NADH dehydrogenase subunit NuoA2 SCD20.17%2C nuoA2%2C NADH dehydrogenase subunit%2C len: 146 aa%3B similar to SW:NUOA_RHOCA (EMBL:AF029365) Rhodobacter capsulatus NADH dehydrogenase I chain A (EC 1.6.5.3) NuoA%2C 126 aa%3B fasta scores: opt: 260 z-score: 336.3 E(): 2.9e-11%3B 36.2%25 identity in 130 aa overlap and to TR:Q9XAQ4 (EMBL:AL078618) Streptomyces coelicolor NuoA%2C NADH dehydrogenase subunit SCD16A.21c%2C 119 aa%3B fasta scores: opt: 231 z-score: 278.0 E(): 7.5e-10%3B 31.4%25 identity in 118 aa overlap. Contains Pfam match to entry PF00507 oxidored_q4%2C NADH-ubiquinone/plastoquinone oxidoreductase%2C chain 3 and possible hydrophobic membrane spanning regions gene gene4646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4599 SCO4600 SCO4600 nuoB2 nuoB2 5024015 5024713 + NADH dehydrogenase subunit NuoB2 SCD20.18%2C nuoB2%2C NADH dehydrogenase subunit%2C len: 232 aa%3B similar to SW:NUKM_BRAOL (EMBL:X82274) Brassica oleracea NADH-ubiquinone oxidoreductase 20 kDa subunit precursor (EC 1.6.5.3) NukM%2C 215 aa%3B fasta scores: opt: 626 z-score: 616.8 E(): 6.9e-27%3B 52.4%25 identity in 166 aa overlap%2C to SW:NUOB_ECOLI (EMBL:X68301) Escherichia coli NADH dehydrogenase I chain B (EC 1.6.5.3) NuoB%2C 220 aa%3B fasta scores: opt: 583 z-score: 575.3 E(): 1.4e-24%3B 58.1%25 identity in 136 aa overlap and to TR:Q9XAQ5 (EMBL:AL07861) Streptomyces coelicolor SCD16A.20c%2C NuoB%2C NADH dehydrogenase subunit%2C 184 aa%3B fasta scores: opt: 531 z-score: 455.5 E(): 9.8e-20%3B 50.7%25 identity in 136 aa overlap. Contains Pfam match to entry PF01058 oxidored_q6%2C NADH ubiquinone oxidoreductase%2C 20 Kd subunit and possible hydrophobic membrane spanning region gene gene4647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4600 SCO4601 SCO4601 SCD39.01 SCD39.01 5024710 5026071 + dehydrogenase SCD39.01%2C possible dehydrogenase%2C len: 453 aa%3B N-terminal region similar to SW:NUC1_RHIME (EMBL:AF055637) Rhizobium meliloti NADH dehydrogenase I chain C1 (EC 1.6.5.3) NuoC%2C 201 aa%3B blastp scores: Score %3D 201 (70.8 bits)%2C Expect %3D 1.7e-15%2C P %3D 1.7e-15%3B Identities %3D 49/134 (36%25)%2C Positives %3D 69/134 (51%25). Contains Pfam match to entry PF00329 complex1_30Kd%2C Respiratory-chain NADH dehydrogenase%2C 30 Kd subunit. Contains 2x conserved repeat: PRRSRSASQGSASQR and rich region in alanine%2C proline and glutamic acid amino acid residues both at C-terminal domain gene gene4648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4601 SCO4602 SCO4602 nuoH2 nuoH2 5026068 5027036 + NADH dehydrogenase subunit NuoH2 SCD39.02%2C nuoH2%2C NADH dehydrogenase subunit%2C len: 322 aa%3B similar to SW:NUOH_ECOLI (EMBL:X68301) Escherichia coli NADH dehydrogenase I chain H (EC 1.6.5.3) NuoH%2C 325 aa%3B fasta scores: opt: 715 z-score: 812.7 E(): 0%3B 37.5%25 identity in 317 aa overlap and to TR:Q9XAR1 (EMBL:AL078618) Streptomyces coelicolor SCD16A.14c NuoH%2C NADH dehydrogenase subunit%2C 467 aa%3B fasta scores: opt: 444 z-score: 437.6 E(): 9.7e-19%3B 37.9%25 identity in 335 aa overlap. Contains Pfam match to entry PF00146 NADHdh%2C NADH dehydrogenases and possible hydrophobic membrane spanning regions gene gene4649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4602 SCO4603 SCO4603 nuoI2 nuoI2 5027036 5027629 + NADH dehydrogenase subunit NuoI2 SCD39.03%2C nuoI2%2C NADH dehydrogenase subunit%2C len: 197 aa%3B similar to SW:NQO9_THETH (EMBL:U52917) Thermus aquaticus NADH-ubiquinone oxidoreductase chain 9 (EC 1.6.5.3) Nqo9%2C 182 aa%3B fasta scores: opt: 263 z-score: 292.1 E(): 8.4e-09%3B 34.9%25 identity in 146 aa overlap and to TR:Q9XAR2 (EMBL:AL078618) Streptomyces coelicolor SCD16A.13c NuoI%2C NADH dehydrogenase subunit%2C 211 aa%3B fasta scores: opt: 295 z-score: 305.4 E(): 2.3e-11%3B 34.9%25 identity in 166 aa overlap. Contains 2x Pfam matches to entry PF00037 fer4%2C 4Fe-4S binding domain and 2x matches to Prosite entry PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene4650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4603 SCO4604 SCO4604 nuoJ2 nuoJ2 5027626 5028219 + NADH dehydrogenase subunit NuoJ2 SCD39.04%2C nuoJ2%2C NADH dehydrogenase subunit%2C len: 197 aa%3B similar to SW:NU6C_SYNY3 (EMBL:X62517) Synechocystis sp. NADH-plastoquinone oxidoreductase chain 6 (EC 1.6.5.3) NdhG%2C 198 aa%3B fasta scores: opt: 311 z-score: 383.0 E(): 7.2e-14%3B 35.7%25 identity in 185 aa overlap and to TR:Q9XAR3 (EMBL:AL078618) Streptomyces coelicolor SCD16A.12c NuoJ%2C NADH dehydrogenase subunit%2C 285 aa%3B fasta scores: opt: 278 z-score: 288.5 E(): 2e-10%3B 33.1%25 identity in 181 aa overlap. Contains Pfam match to entry PF00499 oxidored_q3%2C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 and possible hydrophobic membrane spanning regions gene gene4651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4604 SCO4605 SCO4605 nuoK2 nuoK2 5028219 5028611 + NADH dehydrogenase subunit NuoK2 SCD39.05%2C nuoK2%2C NADH dehydrogenase subunit%2C len: 130 aa%3B similar to SW:NULC_SYNY3 (EMBL:X62517) Synechocystis sp. NADH-plastoquinone oxidoreductase chain 4L (EC 1.6.5.3) NdhE%2C 103 aa%3B fasta scores: opt: 315 z-score: 414.1 E(): 1.3e-15%3B 50.0%25 identity in 100 aa overlap and to TR:Q9XAR4 (EMBL:AL078618) Streptomyces coelicolor SCD16A.11c%2C NuoK%2C NADH dehydrogenase subunit%2C 99 aa%3B fasta scores: opt: 251 z-score: 292.3 E(): 1.2e-10%3B 48.9%25 identity in 90 aa overlap. Contains Pfam match to entry PF00420 oxidored_q2%2C NADH-ubiquinone/plastoquinone oxidoreductase chain 4L and possible hydrophobic membrane spanning regions gene gene4652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4605 SCO4606 SCO4606 nuoL2 nuoL2 5028608 5030602 + NADH dehydrogenase subunit NuoL2 SCD39.06%2C nuoL2%2C NADH dehydrogenase subunit%2C len: 664 aa%3B similar to SW:NU5C_SYNP2 (EMBL:M99378) Synechococcus sp. NADH-plastoquinone oxidoreductase chain 5 (EC 1.6.5.3) NdhF%2C 664 aa%3B fasta scores: opt: 997 z-score: 1098.6 E(): 0%3B 33.7%25 identity in 701 aa overlap and to TR:Q9XAR5 (EMBL:AL078618) Streptomyces coelicolor SCD16A.10c%2C NuoL%2C NADH dehydrogenase subunit%2C 654 aa%3B fasta scores: opt: 902 z-score: 801.3 E(): 0%3B 33.3%25 identity in 681 aa overlap. Contains Pfam matches to entries PF00662 oxidored_q1_N%2C NADH-Ubiquinone oxidoreductase (complex I)%2C chain 5 N-terminus and PF00361 oxidored_q1%2C NADH-Ubiquinone/plastoquinone (complex I)%2C various chains. Also contains possible hydrophobic membrane spanning regions gene gene4653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4606 SCO4607 SCO4607 nuoM2 nuoM2 5030609 5032213 + NADH dehydrogenase subunit NuoM2 SCD39.07%2C nuoM2%2C NADH dehydrogenase subunit%2C len: 534 aa%3B similar to SW:NUOM_ECOLI (EMBL:X68301) Escherichia coli NADH dehydrogenase I chain M (EC 1.6.5.3) NuoM%2C 509 aa%3B fasta scores: opt: 721 z-score: 798.7 E(): 0%3B 33.9%25 identity in 528 aa overlap and to TR:Q9XAR6 (EMBL:AL078618) Streptomyces coelicolor SCD16A.09c%2C NuoM%2C NADH dehydrogenase subunit%2C 523 aa%3B fasta scores: opt: 462 z-score: 441.4 E(): 6e-19%3B 34.1%25 identity in 537 aa overlap. Contains Pfam match to entry PF00361 oxidored_q1%2C NADH-Ubiquinone/plastoquinone (complex I)%2C various chains and possible hydrophobic membrane spanning regions gene gene4654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4607 SCO4608 SCO4608 nuoN2 nuoN2 5032210 5033757 + NADH dehydrogenase subunit NuoN2 SCD39.08%2C nuoN2%2C NADH dehydrogenase subunit%2C len: 515 aa%3B similar to SW:NUON_ECOLI (EMBL:X68301) Escherichia coli NADH dehydrogenase I chain N (EC 1.6.5.3) NuoN%2C 425 aa%3B fasta scores: opt: 601 z-score: 679.6 E(): 2.2e-30%3B 31.6%25 identity in 418 aa overlap and to TR:Q9XAR7 (EMBL:AL078618) Streptomyces coelicolor SCD16A.08c%2C NuoN%2C NADH dehydrogenase subunit%2C 552 aa%3B fasta scores: opt: 346 z-score: 334.0 E(): 5.7e-13%3B 32.0%25 identity in 563 aa overlap. Contains Pfam match to entry PF00361 oxidored_q1%2C NADH-Ubiquinone/plastoquinone (complex I)%2C various chains and match to Prosite entry PS01023 PTR2 family proton/oligopeptide symporters signature 2. Also contains possible hydrophobic membrane spanning regions gene gene4655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4608 SCO4609 SCO4609 SCD39.09 SCD39.09 5033984 5034847 + heat shock protein HtpX metalloprotease gene gene4656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4609 SCO4610 SCO4610 SCD39.10 SCD39.10 5034844 5035260 + hypothetical protein SCD39.10%2C possible integral membrane protein%2C len: 138 aa%3B similar to TR:O53882 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 13.7 kDa protein MTV043.63c%2C 129 aa%3B fasta scores: opt: 509 z-score: 623.4 E(): 3e-27%3B 63.1%25 identity in 122 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4610 SCO4611 SCO4611 SCD39.11 SCD39.11 5035358 5035951 + hypothetical protein SCD39.11%2C unknown%2C len: 197 aa gene gene4658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4611 SCO4612 SCO4612 SCD39.12c SCD39.12c 5036030 5037274 - amino acid transporter SCD39.12c%2C possible amino acid transporter%2C len: 414 aa%3B similar to SW:YJ99_MYCTU (EMBL:Z74025) Mycobacterium tuberculosis hypothetical 45.3 kDa transport protein MTVY39.19%2C 440 aa%3B fasta scores: opt: 1985 z-score: 2014.9 E(): 0%3B 79.0%25 identity in 404 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and possible hydrophobic membrane spanning regions gene gene4659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4612 SCO4613 SCO4613 SCD39.13 SCD39.13 5037414 5037680 + hypothetical protein SCD39.13%2C possible integral membrane protein%2C len: 88 aa%3B similar to SW:YEAQ_ECOLI (EMBL:AE000274) Escherichia coli hypothetical 8.7 kDa protein in GapA-Rnd intergenic region YeaQ%2C 82 aa%3B fasta scores: opt: 233 z-score: 300.6 E(): 2.8e-09%3B 42.5%25 identity in 80 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4613 SCO4614 SCO4614 SCD39.14c SCD39.14c 5037788 5038276 - nucleotide-binding protein nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ%3B the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription gene gene4661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4614 SCO4615 SCO4615 SCD39.15c SCD39.15c 5038758 5040125 - integrase SCD39.15c%2C integrase%2C len: 455 aa%3B identical to previously sequenced TR:Q53966 (EMBL:X71358) Streptomyces coelicolor Int%2C plasmid SLP1 DNA for xis and int genes%2C 455 aa. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family and TTA leucine codon%2C possible target for bldA regulation gene gene4663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4615 SCO4616 SCO4616 SCD39.16c SCD39.16c 5040186 5040371 - excisionase SCD39.16c%2C xis%2C excisionase%2C len: 61 aa%3B identical to previously sequenced TR:Q53965 (EMBL:X71358) Streptomyces coelicolor Xis%2C plasmid SLP1 DNA for xis and int genes%2C 61 aa gene gene4664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4616 SCO4617 SCO4617 SCD39.17c SCD39.17c 5040809 5042281 - ATP-binding protein SCD39.17c%2C possible ATP-binding protein%2C len: 490 aa. Contains match to Prosite entry and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4617 SCO4618 SCO4618 SCD39.18c SCD39.18c 5042283 5043134 - hypothetical protein SCD39.18c%2C unknown%2C len: 283 aa gene gene4666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4618 SCO4619 SCO4619 SCD39.19c SCD39.19c 5043224 5043691 - hypothetical protein SCD39.19c%2C possible integral membrane protein%2C len: 19c aa. Contains possible hydrophobic membrane spanning regions gene gene4667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4619 SCO4620 SCO4620 SCD39.20c SCD39.20c 5043865 5045910 - sporulation-like protein SCD39.20c%2C traB1%2C possible sporulation-related protein%2C len: 681 aa%3B highly similar to TR:Q54679 (EMBL:U23762) Streptomyces phaeochromogenes essential for intermycelial plasmid transfer and pock formation%2C TraB%2C 678 aa%3B fasta scores: opt: 1845 z-score: 2002.9 E(): 0%3B 51.0%25 identity in 679 aa overlap and middle domain similar to middle domain of SW:SP3E_BACSU (EMBL:M17445) Bacillus subtilis stage III sporulation protein E%2C SpoIIIE%2C 787 aa%3B fasta scores: opt: 208 z-score: 224.4 E(): 4.9e-05%3B 26.7%25 identity in 344 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE%2C FtsK/SpoIIIE family. Also contains possible hydrophobic membrane spanning regions gene gene4668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4620 SCO4621 SCO4621 SCD39.21c SCD39.21c 5045925 5046464 - sporulation-like protein SCD39.21c%2C traA1%2C possible sporulation-related protein%2C len: 179 aa%3B highly similar to TR:Q54678 (EMBL:U23762) Streptomyces phaeochromogenes involved in intermycelial plasmid transfer TraA%2C 184 aa%3B fasta scores: opt: 472 z-score: 523.1 E(): 1.1e-21%3B 50.0%25 identity in 172 aa overlap gene gene4669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4621 SCO4622 SCO4622 SCD39.22c SCD39.22c 5046484 5046984 - hypothetical protein SCD39.22c%2C possible integral membrane protein%2C len: 166 aa. Contains possible hydrophobic membrane spanning regions gene gene4670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4622 SCO4623 SCO4623 SCD39.23 SCD39.23 5047012 5047170 + hypothetical protein SCD39.23%2C unknown%2C len: 52 aa gene gene4671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4623 SCO4624 SCO4624 SCD39.24c SCD39.24c 5047328 5047663 - hypothetical protein SCD39.24c%2C unknown%2C len: 111 aa gene gene4672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4624 SCO4625 SCO4625 SCD39.25c SCD39.25c 5047663 5048670 - hypothetical protein SCD39.25c%2C hypothetical protein%2C len: 335 aa%3B similar to TR:Q54674 (EMBL:U23762) Streptomyces phaeochromogenes involved in intramycelial plasmid spread protein SpdB2%2C 371 aa%3B fasta scores: opt: 799 z-score: 782.1 E(): 0%3B 45.1%25 identity in 368 aa overlap. Contains colied-coil region at aprox . 184..262 aa (coinciding with a high hidropihilicity region in the protein) and possible N-terminal region signal peptide sequence gene gene4673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4625 SCO4626 SCO4626 SCD39.26c SCD39.26c 5048667 5049200 - hypothetical protein SCD39.26c%2C unknown%2C len: 177 aa gene gene4674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4626 SCO4627 SCO4627 SCD39.27c SCD39.27c 5049197 5049466 - hypothetical protein SCD39.27c%2C unknown%2C len: 89 aa gene gene4675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4627 SCO4628 SCO4628 SCD39.28 SCD39.28 5049893 5050702 + regulator SCD39.28%2C regulator%2C len: 269 aa%3B identical to C-terminal region of previously sequenced SW:YIMA_STRCO (EMBL:X15866) Streptomyces coelicolor hypothetical 22.9 kDa protein in Imp region (ORFA)%2C 208 aa and similar to TR:Q9X8D2 (EMBL:AL049573) Streptomyces coelicolor KorSA regulatory protein%2C 259 aa%3B fasta scores: opt: 389 z-score: 454.8 E(): 7.3e-18%3B 31.2%25 identity in 253 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene4676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4628 SCO4629 SCO4629 SCD39.29 SCD39.29 5050699 5051364 + hypothetical protein SCD39.29%2C hypothetical protein%2C len: 221 aa%3B identical to previously sequenced SW:YIMC_STRCO (EMBL:X15866) Streptomyces coelicolor hypothetical 22.7 kDa protein in Imp region (ORFC)%2C 203 aa. Contains possible alternative translational starting point downstream gene gene4677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4629 SCO4630 SCO4630 SCD39.30c SCD39.30c 5051465 5052724 - hypothetical protein SCD82.01c%2C unknown (fragment)%2C len: >275 aa~SCD39.30c%2C hypothetical protein (fragment)%2C len: >179 aa. Low G+C content (53.78%25) gene gene4678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4630 SCO4631 SCO4631 SCD82.02c SCD82.02c 5052984 5054666 - hypothetical protein SCD82.02c%2C hypothetical protein%2C len: 560 aa%3B similar to C-terminal region of SW:MCRA_ECOLI (EMBL:M76667) Escherichia coli 5-methylcytosine-specific restriction enzyme A (EC 3.1.21.-) McrA%2C 277 aa%3B fasta scores: opt: 214 z-score: 250.8 E(): 1.5e-06%3B 32.8%25 identity in 131 aa overlap gene gene4679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4631 SCO4632 SCO4632 SCD82.03 SCD82.03 5055828 5058728 + ATP/GTP binding protein SCD82.03%2C possible ATP/GTP binding protein%2C len: 966 aa%3B similar to TR:O86768 (EMBL:AL031035) Streptomyces coelicolor ATP/GTP binding protein SC6A9.38%2C 886 aa%3B fasta scores: opt: 3484 z-score: 3600.2 E(): 0%3B 59.7%25 identity in 886 aa overlap and to C-terminal part of SW:KNLC_CAEEL (EMBL:Z29644) Caenorhabditis elegans kinesin light chain Kcl-2%2C 540 aa%3B fasta scores: opt: 346 z-score: 360.1 E(): 1.2e-12%3B 25.9%25 identity in 340 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4632 SCO4633 SCO4633 SCD82.04c SCD82.04c 5059025 5059681 - hypothetical protein SCD82.04c%2C hypothetical protein%2C len: 218 aa%3B similar to various hypothetical proteins%2C e.g. TR:O07609 (EMBL:Y14083) Bacillus subtilis hypothetical 22.8 kD protein YhfK%2C 214 aa%3B fsta scores: opt: 425 z-score: 473.2 E(): 6.1e-19%3B 36.6%25 identity in 216 aa overlap gene gene4682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4633 SCO4634 SCO4634 SCD82.05c SCD82.05c 5059786 5061090 - hydrolase SCD82.05c%2C possible hydrolase%2C len: 434 aa%3B similar to SW:ATZC_PSESD (EMBL:AF017572) Pseudomonas sp. N-isopropylammelide isopropyl amidohydrolase (EC 3.5.1.-) AtzC%2C 403 aa%3B fasta scores: opt: 292 z-score: 291.5 E(): 8.2e-09%3B 23.5%25 identity in 383 aa overlap gene gene4683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4634 SCO4635 SCO4635 rpmG rpmG 5061599 5061763 + 50S ribosomal protein L33 in Escherichia coli BM108%2C a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function%3B there are paralogous genes in several bacterial genomes%2C and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31%3B the proteins in this group have the CXXC motif gene gene4686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4635 SCO4636 SCO4636 SCD82.07 SCD82.07 5061859 5062311 + hypothetical protein SCD82.07%2C hypothetical protein%2C len: 150 aa%3B similar to SW:YV31_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical 18.4 kD protein CY20G9.31c%2C 166 aa%3B fasta scores: opt: 304 z-score: 373.0 E(): 2.4e-13%3B 35.0%25 identity in 143 aa overlap. Contains TTA leucine codon%2C possible target for bldA regulation gene gene4687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4636 SCO4637 SCO4637 SCD82.08 SCD82.08 5062317 5062745 + hypothetical protein SCD82.08%2C hypothetical protein%2C len: 142 aa%3B similar to TR:O27971 (EMBL:AE000944) Archaeoglobus fulgidus MaoC protein AF2313%2C 151 aa%3B fasta scores: opt: 191 z-score: 246.3 E(): 2.7e-06%3B 34.0%25 identity in 106 aa overlap and to TR:Q9CBJ7 (EMBL:AL583923) Mycobacterium leprae hypothetical protein ML1909%2C 142 aa%3B fasta scores: opt: 456 Z-score: 548.6 E(): 6.3e-23%3B 51.471%25 identity in 136 aa overlap. Contains Pfam match to entry PF01575 MaoC_like%2C MaoC like domain gene gene4688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4637 SCO4638 SCO4638 SCD82.09c SCD82.09c 5062845 5063669 - hypothetical protein SCD82.09c%2C hypothetical protein%2C len: 274 aa%3B similar to TR:Q9XBC9 (EMBL:AL078635) Streptomyces coelicolor rRNA methylase CZA382.22c%2C 259 aa%3B fasta scores: opt: 259 z-score: 291.0 E(): 8.7e-09%3B 30.8%25 identity in 221 aa overlap gene gene4689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4638 SCO4639 SCO4639 SCD82.10 SCD82.10 5063734 5064339 + hypothetical protein SCD82.10%2C hypothetical protein%2C len: 201 aa%3B similar to TR:CAB52009 (EMBL:AL109663) Streptomyces coelicolor transcriptional regulator SC4A10.33%2C 209 aa%3B fasta scores: opt: 138 z-score: 174.2 E(): 0.028%3B 30.3%25 identity in 165 aa overlap gene gene4690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4639 SCO4640 SCO4640 SCD82.11 SCD82.11 5064405 5064998 + TetR family transcriptional regulator SCD82.11%2C possible tetR-family transcriptional regulator%2C len: 197 aa%3B similar to TR:AAF11696 (EMBL:AE002049) Deinococcus radiodurans transcriptional regulator%2C tetR family DR2148%2C 204 aa%3B fasta scores: opt: 175 z-score: 223.6 E(): 4.9e-05%3B 26.2%25 identity in 172 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene4691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4640 SCO4641 SCO4641 SCD82.12 SCD82.12 5065114 5066586 + transmembrane efflux protein SCD82.12%2C possible transmembrane efflux protein%2C len: 490 aa%3B similar to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA%2C 538 aa%3B fasta scores: opt: 952 z-score: 977.6 E(): 0%3B 33.5%25 identity in 466 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and possible hydrophobic membrane spanning regions gene gene4692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4641 SCO4642 SCO4642 SCD82.13 SCD82.13 5066624 5067004 + hypothetical protein SCD82.13%2C unknown%2C len: 126 aa gene gene4693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4642 SCO4643 SCO4643 murB murB 5067001 5068152 + UDP-N-acetylenolpyruvoylglucosamine reductase catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis gene gene4694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4643 SCO4644 SCO4644 add add 5068592 5069623 - adenosine deaminase catalyzes the formation of inosine from adenosine gene gene4695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4644 SCO4645 SCO4645 aspC aspC 5069749 5070975 - aspartate aminotransferase catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate gene gene4696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4645 SCO4646 SCO4646 secE secE 5071396 5071680 + preprotein translocase subunit SecE forms a complex with SecY and SecG%3B SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane%2C a process driven by ATP and a proton-motive force gene gene4698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4646 SCO4647 SCO4647 nusG nusG 5071761 5072663 + transcription antitermination protein SCD82.18%2C nusG%2C transcription antitermination protein%2C len: 300aa%3B identical to previously sequenced SW:NUSG_STRCO (EMBL:D17465) Streptomyces coelicolor transcription antitermination protein NusG. Contains match to Prosite entry PS01014 Transcription termination factor nusG signature. Contains also possible coiled-coil region at aprox. residues 56..75 gene gene4699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4647 SCO4648 SCO4648 rplK rplK 5072851 5073285 + 50S ribosomal protein L11 binds directly to 23S ribosomal RNA gene gene4700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4648 SCO4649 SCO4649 rplA rplA 5073369 5074094 + 50S ribosomal protein L1 in Escherichia coli and Methanococcus%2C this protein autoregulates expression%3B the binding site in the mRNA mimics the binding site in the 23S rRNA gene gene4701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4649 SCO4650 SCO4650 SCD82.21 SCD82.21 5074267 5075124 + lipoprotein SCD82.21%2C yrj1%2C possible lipoprotein%2C len: aa%3B identical to C-terminal of previously sequenced SW:YRJ1_STRCO (EMBL:L24552) Streptomyces coelicolor hypothetical protein in rplJ 5' region (ORF1) (fragment)%2C 256 aa. Contains correctly situated match ot Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal peptide sequence gene gene4702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4650 SCO4651 SCO4651 SCD82.22 SCD82.22 5075273 5076121 + lipoprotein SCD82.22%2C yjr2%2C possible lipoprotein%2C len: 282 aa%3B identical to previously sequenced SW:YRJ2_STRCO (EMBL:L24552) Streptomyces coelicolor hypothetical 30.0 kD protein in rplJ 5' region (ORF2)%2C 282 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and to entry PS00017 ATP/GTP-binding site motif A (P-loop)%2C also contains possible N-terminal region signal peptide sequence gene gene4703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4651 SCO4652 SCO4652 rplJ rplJ 5076440 5076970 + 50S ribosomal protein L10 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit gene gene4704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4652 SCO4653 SCO4653 rplL rplL 5077088 5077471 + 50S ribosomal protein L7/L12 present in two forms%3B L12 is normal%2C while L7 is aminoacylated at the N-terminal serine%3B the only multicopy ribosomal protein%3B 4:1 ratio of L7/L12 per ribosome%3B two L12 dimers bind L10%3B critically important for translation efficiency and fidelity%3B stimulates GTPase activity of translation factors gene gene4705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4653 SCO4654 SCO4654 rpoB rpoB 5078061 5081546 + DNA-directed RNA polymerase subunit beta DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme gene gene4706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4654 SCO4655 SCO4655 rpoC rpoC 5081644 5085543 + DNA-directed RNA polymerase subunit beta' DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter gene gene4707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4655 SCO4656 SCO4656 SCD40A.02 SCD40A.02 5085653 5086240 + hypothetical protein SCD40A.02%2C possible integral membrane protein%2C len: 195 aa. Contains possible hydrophobic membrane spanning regions gene gene4708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4656 SCO4657 SCO4657 SCD40A.03c SCD40A.03c 5086257 5087561 - hypothetical protein SCD40A.03c%2C possible integral membrane protein%2C len: 434 aa%3B similar to TR:Q9EWX4 (EMBL:AL445403) Streptomyces coelicolor integral membrane protein 2SCI34.05%2C 396 aa%3B fasta scores: opt: 678 Z-score: 732.5 E(): 3.6e-33%3B 37.923%25 identity in 414 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4657 SCO4658 SCO4658 SCD40A.04 SCD40A.04 5087653 5088690 + glucosyltransferase SCD40A.04%2C possible glucosyltransferase%2C len: 345 aa%3B similar to TR:O21943 (EMBL:AF021347) Bacteriophage SfII bactoprenol glucosyl transferase Bgt%2C 309 aa%3B fasta scores: opt: 728 z-score: 801.5 E(): 0%3B 39.0%25 identity in 305 aa overlap and to SW:YJ43_SYNY3 (EMBL:D90915) Synechocystis sp. hypothetical 37.6 kD protein Slr1943%2C 331 aa%3B fasta scores: opt: 846 z-score: 929.7 E(): 0%3B 42.4%25 identity in 309 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases and possible hydrophobic membrane spanning regions in C-terminal domain gene gene4710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4658 SCO4659 SCO4659 rpsL rpsL 5088946 5089317 + 30S ribosomal protein S12 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone%3B located at the interface of the 30S and 50S subunits%2C it traverses the body of the 30S subunit contacting proteins on the other side%3B mutations in the S12 gene confer streptomycin resistance gene gene4711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4659 SCO4660 SCO4660 rspG rspG 5089320 5089790 + 30S ribosomal protein S7 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit gene gene4712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4660 SCO4661 SCO4661 fusA fusA 5089830 5091956 + elongation factor G EF-G%3B promotes GTP-dependent translocation of the ribosome during translation%3B many organisms have multiple copies of this gene gene gene4713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4661 SCO4662 SCO4662 tuf tuf 5092130 5093323 + elongation factor Tu EF-Tu%3B promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B when the tRNA anticodon matches the mRNA codon%2C GTP hydrolysis results%3B the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts%3B many prokaryotes have two copies of the gene encoding EF-Tu gene gene4714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4662 SCO4663 SCO4663 SCD40A.09c SCD40A.09c 5093313 5093666 - hypothetical protein SCD40A.09c%2C unknown%2C len: 117 aa gene gene4715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4663 SCO4664 SCO4664 SCD40A.10c SCD40A.10c 5093796 5095631 - hypothetical protein SCD40A.10c%2C possible membrane protein%2C len: 611 aa%3B similar to C-terminal region of TR:CAB71211 (EMBL:AL138538) Streptomyces coelicolor membrane protein SC6D10.16%2C 907 aa%3B fasta scores: opt: 262 z-score: 270.5 E(): 1.2e-07%3B 29.0%25 identity in 630 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4664 SCO4665 SCO4665 SCD40A.11c SCD40A.11c 5095647 5096276 - hypothetical protein SCD40A.11c%2C possible membrane protein%2C len: 209 aa. Contains possible hydrophobic membrane spanning regions gene gene4717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4665 SCO4666 SCO4666 SCD40A.12c SCD40A.12c 5096270 5097010 - ABC transporter ATP-binding protein SCD840A.12c%2C possible ABC-transporter ATP-binding protein%2C len: 246 aa%3B similar to TR:Q9XAA7 (EMBL:AL096837) Streptomyces coelicolor ABC-transporter ATP-binding protein SCF43A.08%2C 264 aa%3B fasta scores: opt: 984 z-score: 1127.0 E(): 0%3B 64.0%25 identity in 239 aa overlap and to TR:CAB76999 (EMBL:AL159178) Streptomyces coelicolor ABC transporter ATP-binding protein SCH22A.30%2C 252 aa%3B fasta scores: opt: 907 z-score: 718.9 E(): 1.5e-34%3B 61.0%25 identity in 236 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4666 SCO4667 SCO4667 SCD40A.13 SCD40A.13 5097181 5098476 + two-component system sensor kinase SCD40A.13%2C possible two-component system sensor kinase%2C len: 431 aa%3B C-terminal region similar to TR:Q9ZBS5 (EMBL:AL034446) Streptomyces coelicolor sensor kinase SC1A9.27c%2C 303 aa%3B fasta scores: opt: 378 z-score: 412.0 E(): 1.6e-15%3B 31.9%25 identity in 313 aa overlap. Contains possible N-terminal region hydrophobic membrane spanning regions gene gene4719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4667 SCO4668 SCO4668 SCD40A.14 SCD40A.14 5098476 5099108 + two-component system response regulator SCD40A.14%2C possible two-component system response regulator%2C len: 210 aa%3B similar to TR:CAB61727 (EMBL:AL133220) Streptomyces coelicolor SCC75A.27c%2C 228 aa%3B fasta scores: opt: 732 z-score: 839.5 E(): 0%3B 58.6%25 identity in 210 aa overlap. Contains two Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Contains also possible helix-turn-helix motif at residues 162..183 (+3.44 SD) gene gene4720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4668 SCO4669 SCO4669 SCD40A.15 SCD40A.15 5099276 5100415 + hypothetical protein SCD40A.15%2C possible membrane protein%2C len: 379 aa%3B similar to TR:CAB66261 (EMBL:AL136518) Streptomyces coelicolor membrane protein SCC123.21c%2C 356 aa%3B fasta scores: opt: 350 z-score: 356.2 E(): 2.1e-12%3B 30.1%25 identity in 356 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4669 SCO4670 SCO4670 SCD40A.16c SCD40A.16c 5100500 5101891 - serine protease SCD840A.16c%2C probable serine protease precursor%2C len: 463 aa%3B similar to SW:PRTC_STRGR (EMBL:L29018) Streptomyces griseus serine protease C precursor (EC 3.4.21.-) SprC%2C 457 aa%3B fasta scores: opt: 1761 z-score: 1679.7 E(): 0%3B 59.4%25 identity in 458 aa overlap and to TR:Q9XA96 (EMBL:AL096837) Streptomyces coelicolor serine protease SCF43A.19%2C 458 aa%3B fasta scores: opt: 1637 z-score: 1264.0 E(): 0%3B 55.9%25 identity in 460 aa overlap. Contains Pfam match to entry PF00089 trypsin%2C Trypsin and matches to Prosite entries PS00135 Serine proteases%2C trypsin family%2C serine active site and PS00178 Aminoacyl-transfer RNA synthetases class-I signature. Contains also possible N-terminal region signal peptide sequence gene gene4722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4670 SCO4671 SCO4671 SCD40A.17c SCD40A.17c 5102043 5102990 - LysR family transcriptional regulator SCD40A.17c%2C probable lysR-family regulatory protein%2C len: 315 aa%3B similar to SW:MPRR_STRCO (EMBL:Z11929) Streptomyces coelicolor small neutral protease regulatory protein MprR%2C 316 aa%3B fasta scores: opt: 541 z-score: 619.1 E(): 4.7e-27%3B 36.7%25 identity in 308 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Contains also possible helix-turn-helix motif at residues 18..39 (+4.31 SD). Contains also TTA leucine codon%2C possible target for bldA regulation gene gene4723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4671 SCO4672 SCO4672 SCD40A.18c SCD40A.18c 5103076 5104845 - hypothetical protein SCD40A.18c%2C possible hypothetical protein%2C len: 589 aa. Contains possible N-terminal region signal peptide sequence gene gene4724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4672 SCO4673 SCO4673 SCD40A.19c SCD40A.19c 5104850 5105869 - DeoR family transcriptional regulator SCD40A.19c%2C possible deoR-family transcriptional regulator%2C len: 339 aa%3B similar to TR:Q54822 (EMBL:L37338) Streptomyces peucetius repressor DnrO%2C 340 aa%3B fasta scores: opt: 660 z-score: 749.1 E(): 0%3B 38.7%25 identity in 333 aa overlap. Contains match to Prosite entry PS00894 Bacterial regulatory proteins%2C deoR family signature and possible helix-turn-helix motif at residues 27..48 (+5.18 SD) gene gene4725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4673 SCO4674 SCO4674 SCD40A.20 SCD40A.20 5105881 5106318 + hypothetical protein SCD40A.20%2C hypothetical protein%2C len: 145 aa%3B similar to TR:O06633 (EMBL:Z95618) Mycobacterium tuberculosis hypothetical 12.5 kD protein MTCY07H7A.08c%2C 115 aa%3B fasta scores: opt: 249 z-score: 314.3 E(): 4.5e-10%3B 39.5%25 identity in 119 aa overlap gene gene4726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4674 SCO4675 SCO4675 SCD40A.21c SCD40A.21c 5106331 5107239 - hypothetical protein SCD40A.21c%2C hypothetical protein%2C len: 302 aa%3B similar to TR:Q9XD94 (EMBL:AF106004) Streptomyces coelicolor hypothetical 34.1 kD protein%2C 304 aa%3B fasta scores: opt: 850 z-score: 992.1 E(): 0%3B 45.0%25 identity in 300 aa overlap. Contains match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene4727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4675 SCO4676 SCO4676 SCD31.01c SCD31.01c 5107257 5108129 - hypothetical protein SCD31.01c%2C unknown (fragment)%2C len: >147 aa~SCD40A.22c%2C unknown (fragment)%2C len: > 176 aa gene gene4728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4676 SCO4677 SCO4677 SCD31.02c SCD31.02c 5108377 5108811 - regulatory protein SCD31.02c%2C possible regulatory protein%2C len: 144 aa%3B similar to TR:CAB60156 (EMBL:AL132824) Streptomyces coelicolor regulatory protein SCAH10.02%2C 160 aa%3B fasta scores: opt: 396 z-score: 500.7 E(): 1.9e-20%3B 51.7%25 identity in 143 aa overlap gene gene4729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4677 SCO4678 SCO4678 SCD31.03 SCD31.03 5108924 5109772 + hypothetical protein SCD31.03%2C conserved hypothetical protein%2C len: 282 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB66187 (EMBL:AL136500) Streptomyces coelicolor hypothetical 31.7 kD protein SC1G2.15c%2C 284 aa%3B fasta scores: opt: 1359 z-score: 1611.1 E(): 0%3B 71.7%25 identity in 279 aa overlap gene gene4730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4678 SCO4679 SCO4679 SCD31.04 SCD31.04 5109769 5109960 + hypothetical protein SCD31.04%2C conserved hypothetical protein%2C len: 63 aa%3B similar to TR:CAB66186 (EMBL:AL136500) Streptomyces coelicolor hypothetical 7.7 kD protein SC1G2.14c%2C 73 aa%3B fasta scores: opt: 265 z-score: 399.0 E(): 8.5e-15%3B 66.0%25 identity in 53 aa overlap gene gene4731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4679 SCO4680 SCO4680 SCD31.05c SCD31.05c 5109911 5110801 - DNA-binding protein SCD31.05c%2C possible DNA-binding protein%2C len: 296 aa%3B similar to TR:CAB53273 (EMBL:AL109972) Streptomyces coelicolor DNA binding protein SCJ9A.12c%2C 279 aa%3B fasta scores: opt: 782 z-score: 910.0 E(): 0%3B 46.1%25 identity in 271 aa overlap gene gene4732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4680 SCO4681 SCO4681 SCD31.06 SCD31.06 5110846 5111655 + short chain dehydrogenase SCD31.06%2C probable short chain dehydrogenase%2C len: 296 aa%3B similar to TR:CAB56135 (EMBL:AL117669) Streptomyces coelicolor short chain dehydrogenase SCF12.09%2C 249 aa%3B fasta scores: opt: 1003 z-score: 1070.0 E(): 0%3B 65.2%25 identity in 244 aa overlap and to SW:SDR1_PICAB (EMBL:X74115) Picea abies short-chain type dehydrogenase/reductase (EC 1.-.-.-) Sdr1%2C271 aa%3B fasta scores: opt: 576 z-score: 619.1 E(): 4.7e-27%3B 47.8%25 identity in 251 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus gene gene4733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4681 SCO4682 SCO4682 SCD31.07 SCD31.07 5111657 5111866 + tautomerase SCD31.07%2C possible tautomerase%2C len: 69 aa%3B similar to TR:O25581 (EMBL:AE000602) Helicobacter pylori 4-oxalocrotonate tautomerase (DmpI) HP0924%2C 68 aa%3B fasta scores: opt: 114 z-score: 175.1 E(): 0.025%3B 32.2%25 identity in 59 aa overlap. Contains Pfam match to entry PF01361 Tautomerase%2C Tautomerase enzyme gene gene4734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4682 SCO4683 SCO4683 gdhA gdhA 5112014 5113399 + glutamate dehydrogenase converts 2-oxoglutarate to glutamate%3B in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction%3B uses NADPH%3B forms a homohexamer gene gene4735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4683 SCO4684 SCO4684 SCD31.09 SCD31.09 5113748 5113951 + cold shock protein SCD31.09%2C scoF3%2C cold shock protein%2C len: 67 aa%3B highly similar to TR:O54117 (EMBL:AL021529) Streptomyces coelicolor cold-shock domain protein SC10A5.26c%2C 67 aa%3B fasta scores: opt: 432 z-score: 604.3 E(): 3.1e-26%3B 97.0%25 identity in 67 aa overlap and to SW:CSPF_STRCO (EMBL:X92686) Streptomyces coelicolor cold shock protein ScoF%2C 67 aa%3B fasta scores: opt: 370 z-score: 520.7 E(): 1.4e-21%3B 80.6%25 identity in 67 aa overlap. Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain and match to Prosite entry PS00352 'Cold-shock' DNA-binding domain signature gene gene4736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4684 SCO4685 SCO4685 SCD31.10 SCD31.10 5114147 5115568 + DEAD/DEAH box helicase SCD31.10%2C probable DEAD-box RNA helicase%2C len: 473 aa%3B similar to TR:O54116 (EMBL:AL021529) Streptomyces coelicolor DEAD-box RNA helicase SC10A5.25c%2C 498 aa%3B fasta scores: opt: 2591 z-score: 2737.2 E(): 0%3B 88.1%25 identity in 461 aa overlap and to SW:RHLE_ECOLI (EMBL:L02123) Escherichia coli ATP-dependent RNA helicase RhlE%2C 454 aa%3B fasta scores: opt: 845 z-score: 896.7 E(): 0%3B 36.8%25 identity in 427 aa overlap. Contains Pfam match to entry PF00270 DEAD%2C DEAD/DEAH box helicase Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain 2x PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4685 SCO4686 SCO4686 SCD31.11 SCD31.11 5115614 5115925 + hypothetical protein SCD31.11%2C hypothetical protein%2C len: 103 aa%3B similar to TR:O54115 (EMBL:AL021529) Streptomyces coelicolor hypothetical 14.3 kD protein SC10A5.24c%2C 134 aa%3B fasta scores: opt: 353 z-score: 464.3 E(): 2e-18%3B 75.3%25 identity in 73 aa overlap gene gene4738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4686 SCO4687 SCO4687 SCD31.12c SCD31.12c 5115961 5116320 - hypothetical protein SCD31.12c%2C unknown%2C len: 119 aa gene gene4739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4687 SCO4688 SCO4688 SCD31.13c SCD31.13c 5116372 5116728 - hypothetical protein SCD31.13c%2C hypothetical protein%2C len: 118 aa%3B highly similar to TR:O54113 (EMBL:AL021529) Streptomyces coelicolor hypothetical 12.6 kD protein SC10A5.22%2C 112 aa%3B fasta scores: opt: 579 z-score: 753.8 E(): 0%3B 87.0%25 identity in 100 aa overlap gene gene4740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4688 SCO4689 SCO4689 SCD31.14 SCD31.14 5117228 5117560 + hypothetical protein SCD31.14%2C hypothetical protein%2C len: 110 aa%3B similar to TR:O06194 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 12.3 kD protein MTCY1A10.14%2C 117 aa%3B fasta scores: opt: 407 z-score: 548.1 E(): 4.2e-23%3B 56.0%25 identity in 109 aa overlap gene gene4741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4689 SCO4690 SCO4690 SCD31.15 SCD31.15 5117634 5117876 + hypothetical protein SCD31.15%2C possible membrane protein%2C len: 80 aa%3B similar to N-terminal region of TR:Q9WX28 (EMBL:AL079345) Streptomyces coelicolor membrane protein SCE68.03%2C 441 aa%3B fasta scores: opt: 237 z-score: 347.7 E(): 6.2e-12%3B 52.9%25 identity in 68 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4690 SCO4691 SCO4691 SCD31.16 SCD31.16 5117928 5118521 + hypothetical protein SCD31.16%2C possible membrane protein%2C len: 197 aa%3B similar to C-terminal region of TR:Q9WX28 (EMBL:AL079345) Streptomyces coelicolor membrane protein SCE68.03%2C 441 aa%3B fasta scores: opt: 495 z-score: 618.7 E(): 5e-27%3B 41.5%25 identity in 205 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4691 SCO4692 SCO4692 SCD31.17 SCD31.17 5118613 5119260 + hypothetical protein SCD31.17%2C hypothetical protein%2C len: 215 aa%3B similar to TR:Q9F3G1 (EMBL:AL392175) Streptomyces coelicolor hypothetical protein 2SCD4.10c%2C 201 aa%3B fasta scores: opt: 776 Z-score: 867.6 E(): 1.1e-40%3B 59.000%25 identity in 200 aa overlap gene gene4744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4692 SCO4693 SCO4693 SCD31.18 SCD31.18 5119357 5119617 + hypothetical protein SCD31.18%2C membrane protein%2C len: 86 aa. Contains possible hydrophobic membrane spanning region gene gene4745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4693 SCO4694 SCO4694 SCD31.19 SCD31.19 5119650 5119892 + hypothetical protein SCD31.19%2C hypothetical protein%2C len: 80 aa%3B similar to part of TR:O54162 (EMBL:AL021411) Streptomyces coelicolor hypothetical 40.9 kD protein SC7H1.03c%2C 391 aa%3B fasta scores: opt: 301 z-score: 411.2 E(): 1.8e-15%3B 58.8%25 identity in 80 aa overlap gene gene4746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4694 SCO4695 SCO4695 SCD31.20 SCD31.20 5119938 5120483 + hypothetical protein SCD31.20%2C hypothetical protein%2C len: 181 aa%3B similar to C-terminal part of many hypothetical proteins%2C e.g. TR:O54162 (EMBL:AL021411) Streptomyces coelicolor hypothetical 40.9 kD protein SC7H1.03c%2C 391 aa%3B fasta scores: opt: 594 z-score: 691.0 E(): 4.7e-31%3B 53.5%25 identity in 185 aa overlap gene gene4747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4695 SCO4696 SCO4696 SCD31.21 SCD31.21 5120514 5120981 + hypothetical protein SCD31.21%2C unknown%2C len: 155 aa gene gene4748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4696 SCO4697 SCO4697 SCD31.22 SCD31.22 5121109 5122923 + hypothetical protein SCD31.22%2C possible integral membrane protein%2C len: 604 aa%3B N-terminal region similar to TR:Q9XD98 (EMBL:AF106004) Streptomyces coelicolor hypothetical 27.5 kD protein%2C 249 aa%3B fasta scores: opt: 953 z-score: 1009.5 E(): 0%3B 58.7%25 identity in 235 aa overlap and C-terminal region highly similar to C-terminal region of TR:O86757 (EMBL:AL031035) Streptomyces coelicolor hypothetical 28.2 kD protein SC6A9.25%2C 254 aa%3B fasta scores: opt: 309 z-score: 332.3 E(): 4.4e-11%3B 92.0%25 identity in 50 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C a possible hydrophobic membrane spanning region and a possible coiled-coil region at aprox residues 170..210 gene gene4749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4697 SCO4698 SCO4698 SCD31.23 SCD31.23 5122836 5123855 + IS1652 transposase SCD31.23%2C probable insertion element IS1652 transposase%2C len: 339 aa%3B identical to TR:CAB71807 (EMBL:AL138662) Streptomyces coelicolor transposase SC8E4A.02%2C 339 aa and highly similar to various other Streptomyces coelicolor transposases gene gene4750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4698 SCO4699 SCO4699 SCD31.24 SCD31.24 5123855 5126638 + Rhs protein SCD31.24%2C possible Rhs protein%2C len: 927 aa%3B similar to C-terminal domain of SW:RHSB_ECOLI (EMBL:L02370) Escherichia coli RhsB protein precursor%2C 1411 aa%3B fasta scores: opt: 510 z-score: 568.8 E(): 3e-24%3B 26.4%25 identity in 954 aa overlap gene gene4751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4699 SCO4700 SCO4700 SCD31.25 SCD31.25 5126659 5127108 + hypothetical protein SCD31.25%2C unknown%2C len: 149 aa gene gene4752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4700 SCO4701 SCO4701 rpsJ rpsJ 5127609 5127917 + 30S ribosomal protein S10 NusE%3B involved in assembly of the 30S subunit%3B in the ribosome%2C this protein is involved in the binding of tRNA%3B in Escherichia coli this protein was also found to be involved in transcription antitermination%3B NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination%3B binding of NusB/S10 to boxA nucleates assembly of the antitermination complex gene gene4753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4701 SCO4702 SCO4702 rplC rplC 5127934 5128578 + 50S ribosomal protein L3 binds directly near the 3' end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B essential for peptidyltransferase activity%3B mutations in this gene confer resistance to tiamulin gene gene4754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4702 SCO4703 SCO4703 rplD rplD 5128587 5129246 + 50S ribosomal protein L4 L4 is important during the early stages of 50S assembly%3B it initially binds near the 5' end of the 23S rRNA gene gene4755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4703 SCO4704 SCO4704 rplW rplW 5129246 5129665 + 50S ribosomal protein L23 binds third domain of 23S rRNA and protein L29%3B part of exit tunnel gene gene4756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4704 SCO4705 SCO4705 rplB rplB 5129706 5130542 + 50S ribosomal protein L2 one of the primary rRNA-binding proteins%3B required for association of the 30S and 50S subunits to form the 70S ribosome%2C for tRNA binding and peptide bond formation gene gene4757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4705 SCO4706 SCO4706 rpsS rpsS 5130555 5130836 + 30S ribosomal protein S19 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA gene gene4758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4706 SCO4707 SCO4707 rplV rplV 5130849 5131226 + 50S ribosomal protein L22 binds specifically to 23S rRNA during the early stages of 50S assembly%3B makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome%3B mutations in this gene result in erythromycin resistance%3B located near peptidyl-transferase center gene gene4759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4707 SCO4708 SCO4708 rpsC rpsC 5131226 5132059 + 30S ribosomal protein S3 forms a complex with S10 and S14%3B binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation gene gene4760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4708 SCO4709 SCO4709 rplP rplP 5132065 5132484 + 50S ribosomal protein L16 located in the peptidyl transferase center and may be involved in peptidyl transferase activity%3B similar to archaeal L10e gene gene4761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4709 SCO4710 SCO4710 rpmC rpmC 5132484 5132708 + 50S ribosomal protein L29 one of the stabilizing components for the large ribosomal subunit gene gene4762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4710 SCO4711 SCO4711 rpsQ rpsQ 5132708 5132995 + 30S ribosomal protein S17 primary binding protein%3B helps mediate assembly%3B involved in translation fidelity gene gene4763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4711 SCO4712 SCO4712 rplN rplN 5133103 5133471 + 50S ribosomal protein L14 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase gene gene4764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4712 SCO4713 SCO4713 rplX rplX 5133474 5133797 + 50S ribosomal protein L24 assembly initiator protein%3B binds to 5' end of 23S rRNA and nucleates assembly of the 50S%3B surrounds polypeptide exit tunnel gene gene4765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4713 SCO4714 SCO4714 rplE rplE 5133797 5134354 + 50S ribosomal protein L5 part of 50S and 5S/L5/L18/L25 subcomplex%3B contacts 5S rRNA and P site tRNA%3B forms a bridge to the 30S subunit in the ribosome by binding to S13 gene gene4766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4714 SCO4715 SCO4715 rpsN rpsN 5134360 5134545 + 30S ribosomal protein S14 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit%3B similar to what is observed with proteins L31 and L33%2C some proteins in this family contain CXXC motifs that are involved in zinc binding%3B if two copies are present in a genome%2C then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc%3B the proteins in this group appear to contain the zinc-binding motif gene gene4767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4715 SCO4716 SCO4716 rpsH rpsH 5134757 5135155 + 30S ribosomal protein S8 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit gene gene4768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4716 SCO4717 SCO4717 rplF rplF 5135180 5135719 + 50S ribosomal protein L6 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein%3B RNA-binding appears to be in the C-terminal domain%3B mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain%3B it has been localized to a region between the base of the L7/L12 stalk and the central protuberance gene gene4769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4717 SCO4718 SCO4718 rplR rplR 5135723 5136106 + 50S ribosomal protein L18 binds 5S rRNA along with protein L5 and L25 gene gene4770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4718 SCO4719 SCO4719 rpsE rpsE 5136150 5136755 + 30S ribosomal protein S5 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body%3B contacts S4 and S8%3B with S4 and S12 plays a role in translational accuracy%3B mutations in this gene result in spectinomycin resistance gene gene4771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4719 SCO4720 SCO4720 rpmD rpmD 5136758 5136940 + 50S ribosomal protein L30 L30 binds domain II of the 23S rRNA and the 5S rRNA%3B similar to eukaryotic protein L7 gene gene4772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4720 SCO4721 SCO4721 rplO rplO 5136943 5137398 + 50S ribosomal protein L15 late assembly protein gene gene4773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4721 SCO4722 SCO4722 secY secY 5137655 5138968 + preprotein translocase subunit SecY forms heterotrimeric complex in the membrane%3B in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG%3B the SecG subunit is not essential%3B in bacteria translocation is driven via the SecA ATPase gene gene4774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4722 SCO4723 SCO4723 adk adk 5138968 5139621 + adenylate kinase essential enzyme that recycles AMP in active cells%3B converts ATP and AMP to two molecules of ADP gene gene4775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4723 SCO4724 SCO4724 map map 5139773 5140609 + methionine aminopeptidase SC6G4.02%2C map%2C methionine aminopeptidase%2C len: 278 aa%3B identical to TR:O54208 (EMBL:X83011) methionine aminopeptidase (278 aa) and highly similar to many e.g.AMPM_BACSU methionine aminopeptidase (EC 3.4.11.18) (248 aa)%2C fasta scores%3B opt: 546 z-score: 922.2 E(): 0%2C 44.5%25 identity in 256 aa overlap. Also similar to S. coelicolor map2 (E(): 3.2e-3 3%2C 46.8%25 identity in 267 aa overlap). Contains PS00680 Meth ionine aminopeptidase subfamily 1 signature and Pfam match to entry PF00557 pep_M24%2C metallopeptidase family M24%2C scor e 194.80%2C E-value 1.4e-54 gene gene4776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4724 SCO4725 SCO4725 infA infA 5140751 5140972 + translation initiation factor IF-1 stimulates the activities of the other two initiation factors%2C IF-2 and IF-3 gene gene4777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4725 SCO4726 SCO4726 rpmJ rpmJ 5141041 5141154 + 50S ribosomal protein L36 smallest protein in the large subunit%3B similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc%3B the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion%3B the proteins in this group have the motif gene gene4778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4726 SCO4727 SCO4727 rpsM rpsM 5141343 5141723 + 30S ribosomal protein S13 located at the top of the head of the 30S subunit%2C it contacts several helices of the 16S rRNA%3B makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5%3B contacts P-site tRNA gene gene4779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4727 SCO4728 SCO4728 rpsK rpsK 5141791 5142195 + 30S ribosomal protein S11 located on the platform of the 30S subunit%2C it bridges several disparate RNA helices of the 16S rRNA%3B forms part of the Shine-Dalgarno cleft in the 70S ribosome%3B interacts with S7 and S18 and IF-3 gene gene4780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4728 SCO4729 SCO4729 rpoA rpoA 5142327 5143349 + DNA-directed RNA polymerase subunit alpha catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme gene gene4781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4729 SCO4730 SCO4730 rplQ rplQ 5143544 5144050 + 50S ribosomal protein L17 is a component of the macrolide binding site in the peptidyl transferase center gene gene4782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4730 SCO4731 SCO4731 truA truA 5144190 5145044 + tRNA pseudouridine synthase A mediates pseudouridylation (positions 38%2C 39%2C 40) at the tRNA anticodon region which contributes to the structural stability gene gene4783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4731 SCO4732 SCO4732 SC6G4.10c SC6G4.10c 5145064 5145963 - hypothetical protein SC6G4.10c%2C membrane protein%2C len: 299 aa%3B contains possible transmembrane domain near N-terminus gene gene4784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4732 SCO4733 SCO4733 SC6G4.11 SC6G4.11 5146008 5147243 + hypothetical protein SC6G4.11%2C probable integral membrane protein%2C len: 4 11 aa%3B some similarity to hypothetical proteins from M. tuberculosis and M. leprae e.g. TR:P71970 (EMBL:) MTCY441.42 ( Rv2673) (433 aa)%2C fasta scores%3B opt: 383 z-score: 365.0 E() : 4.6e-13%2C 29.6%25 identity in 422 aa overlap gene gene4785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4733 SCO4734 SCO4734 rplM rplM 5147451 5147894 + 50S ribosomal protein L13 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit gene gene4786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4734 SCO4735 SCO4735 rpsI rpsI 5147937 5148449 + 30S ribosomal protein S9 forms a direct contact with the tRNA during translation gene gene4787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4735 SCO4736 SCO4736 glmM glmM 5148674 5150032 + phosphoglucosamine mutase catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate gene gene4788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4736 SCO4737 SCO4737 SC6G4.15c SC6G4.15c 5150160 5151107 - hypothetical protein SC6G4.15c%2C probable integral membrane protein%2C len: 452 aa%3B simialar to hypothetical protein from Streptomyces albus TR:Q53581 (EMBL:U03114) partial CDS (208 aa)%2C fasta scores%3B opt: 821 z-score: 1301.7 E(): 0%2C 67.0%25 identity in 203 aa overlap gene gene4789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4737 SCO4738 SCO4738 coaA coaA 5151168 5152157 - pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis gene gene4790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4738 SCO4739 SCO4739 SC6G4.17 SC6G4.17 5152417 5153223 + lipoprotein SC6G4.17%2C probable lipoprotein%2C len: 268 aa%3B contain s N-terminal signal sequence and appropriately positioned P S00013 Prokaryotic membrane lipoprotein lipid attachment si te gene gene4791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4739 SCO4740 SCO4740 glmS1 glmS1 5153334 5155181 + glucosamine--fructose-6-phosphate aminotransferase Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source gene gene4792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4740 SCO4741 SCO4741 SC6G4.19c SC6G4.19c 5155213 5155785 - hypothetical protein SC6G4.19c%2C unknown%2C len: 190 aa%3B contains Pro-Ser- r ich domain at N-terminus gene gene4793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4741 SCO4742 SCO4742 SC6G4.20c SC6G4.20c 5155831 5157288 - hypothetical protein SC6G4.20c%2C unknown%2C len: 485 aa%3B similar to hypothetical proteins from many organisms e.g. Y115_MYCTU MTCY77.05 C (Rv3433c) (473 aa)%2C fasta scores%3B opt: 563 z-score: 730.1 E(): 0%2C 48.5%25 identity in 489 aa overlap gene gene4794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4742 SCO4743 SCO4743 SC6G4.21 SC6G4.21 5157368 5157973 + hypothetical protein SC6G4.21%2C unknown%2C len: 201 aa%3B similar%2C in part%2C to a hypothetical protein from Streptomyces purpurascens TR:Q 54855 (EMBL:X61931) (90 aa)%2C fasta scores%3B opt: 376 z-score : 584.3 E(): 2.8e-25%2C 58.5%25 identity in 94 aa overlap. Cont ains helix-turn-helix motif at aa 28-49 (Score 2176%2C +6.60 SD) gene gene4795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4743 SCO4744 SCO4744 acpS acpS 5158001 5158372 - 4'-phosphopantetheinyl transferase Catalyzes the formation of holo-ACP%2C which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids gene gene4796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4744 SCO4745 SCO4745 alr alr 5158508 5159683 + alanine racemase SC6G4.23%2C alr%2C probable alanine racemase%2C len: 391 a a%3B similar to many e.g. ALR_BACST alanine racemase (EC 5.1. 1.1) (388 aa)%2C fasta scores%3B opt: 532 z-score: 774.2 E(): 0 %2C 38.6%25 identity in 376 aa overlap. Contains PS00395 Alanine racemase pyridoxal-phosphate attachment site gene gene4797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4745 SCO4746 SCO4746 SC6G4.24 SC6G4.24 5159838 5161100 + lipase SC6G4.24%2C possible lipase%2C len: 420 aa%3B some similar ity to e.g. TR:Q59695 (EMBL:L35343) Pseudomonas putida dihy drolipoamide acetyltransferase (370 aa)%2C fasta scores%3B opt: 134 z-score: 204.4 E(): 0.00041%2C 27.0%25 identity in 352 aa overlap. Contains PS00120 Lipases%2C serine active site and P fam match to entry PF00561 abhydrolase%2C alpha/beta hydrolas e fold%2C score 79.50%2C E-value 7e-20. Contains possible hydrophobic membrane spanning region gene gene4798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4746 SCO4747 SCO4747 SC6G4.25 SC6G4.25 5161171 5161617 + ATP/GTP binding protein SC6G4.25%2C probable ATP/GTP binding protein%2C len: 148 aa%3B similar to hypothetical proteins from many organisms e .g. YJEE_ECOLI (153 aa)%2C fasta scores%3B opt: 228 z-score: 29 2.3 E(): 5.1e-09%2C 34.1%25 identity in 135 aa overlap and Y097 _MYCTU MTCY78.07 (168 aa)%2C fasta scores%3B opt: 377 z-score: 532.7 E(): 2.1e-22%2C 50.8%25 identity in 120 aa overlap. Conta ins PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4747 SCO4748 SCO4748 SC6G4.26 SC6G4.26 5161764 5162000 + hypothetical protein SC6G4.26%2C unknown%2C len: 78 aa%3B contains Gln-rich C-t erminus gene gene4800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4748 SCO4749 SCO4749 SC6G4.27c SC6G4.27c 5162036 5162590 - hypothetical protein SC6G4.27c%2C possible hypothetical protein%2C len: 184 aa%3B similar to TR:Q9KZZ6 (EMBL:AL353815) Streptomyces coelicolor hypothetical protein SCD6.08%2C 189 aa%3B fasta scores:opt: 495 Z-score: 540.3 E(): 1.8e-22%3B 48.066%25 identity in 181 aa overlap. Contains possible N-terminal signal sequence gene gene4801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4749 SCO4750 SCO4750 SC6G4.28 SC6G4.28 5162784 5163437 + hypothetical protein SC6G4.28%2C unknown%2C len: 217 aa%3B similar to hypothetical proteins from many organisms e.g. YEAZ_ECOLI (231 aa)%2C fasta scores%3B opt: 257 z-score: 332.3 E(): 3e-11%2C 33.9%25 ide ntity in 221 aa overlapand Y098_MYCTU MTCY78.08 (211 aa)%2C f asta scores%3B opt: 453 z-score: 467.2 E(): 9.3e-19%2C 48.1%25 i dentity in 212 aa overlap. Also some similarity to downstre am protein gcp (SC6G4.30%3B E(): 0.00023%2C 26.5%25 identity in 2 34 aa overlap) gene gene4802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4750 SCO4751 SCO4751 SC6G4.29 SC6G4.29 5163434 5163967 + acetyltransferase SC6G4.29%2C probable acetyltransferase%2C len: 177 aa%3B s imilar to e.g. RIMI_ECOLI ribosomal-protein-alanine acetyl transferase (148 aa)%2C fasta scores%3B opt: 166 z-score: 257.4 E(): 4.5e-07%2C 33.3%25 identity in 120 aa overlap. Contains Pf am match to entry PF00583 Acetyltransf%2C Acetyltransferase ( GNAT) family%2C score 59.60%2C E-value 6.7e-14 gene gene4803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4751 SCO4752 SCO4752 gcp gcp 5163960 5165084 + DNA-binding/iron metalloprotein/AP endonuclease in most organisms%2C only the N-terminal domain is present in a single polypeptide%3B in some archaea this domain is fused to a kinase domain%3B this gene is essential for growth in Escherichia coli and Bacillus subtilis%3B the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins%3B the Pyrococcus structure shows DNA-binding properties%2C iron-binding%2C ATP-binding%2C and AP endonuclease activity gene gene4804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4752 SCO4753 SCO4753 SC6G4.31 SC6G4.31 5165081 5165353 + hypothetical protein SC6G4.31%2C unknown%2C len: 90 aa gene gene4805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4753 SCO4754 SCO4754 SC6G4.32 SC6G4.32 5165438 5166505 + transcriptional regulator SC6G4.32%2C probable transcriptional regulator%2C len: 355 aa%3B similar to many members of the lacI family e.g. RBSR _ECOLI ribose operon repressor (329 aa)%2C fasta scores%3B opt: 588 z-score: 718.4 E(): 9.4e-33%2C 34.8%25 identity in 305 aa overlap. Contains PS00356 Bacterial regulatory proteins%2C lacI family signature%2C helix-turn-helix motif at aa 20-41 (Score 2255%2C +6.87 SD) and Pfam matches to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C score 36.90%2C E -value 6.1e-09 and to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C score 127.80%2C E-va lue 2e-34 gene gene4806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4754 SCO4755 SCO4755 SC6G4.33 SC6G4.33 5166604 5167686 + transcriptional regulator SC6G4.33%2C possible transcriptional regulator%2C len: 360 aa%3B similar to many membrane bound regulators e.g. TR:P96499 (EMBL:U56901) B. subtilis transcriptional regulator (391 aa)%2C fasta scores%3B opt: 333 z-score: 2 78.7 E(): 2.9e-08%2C 28.1%25 identity in 352 aa overlap. Also similar to SC1C3.08c (E(): 0%2C 52.7%25 identity in 334 aa overlap. Contains possible transmembrane domain near N-terminus gene gene4807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4755 SCO4756 SCO4756 SC6G4.34 SC6G4.34 5167797 5168153 + hypothetical protein SC6G4.34%2C unknown%2C len: 118 aa%3B similar to a hypothe tical protein from Rhizobium meliloti TR:Q52996 (EMBL:L3926 5) (100 aa)%2C fasta scores%3B opt: 130 z-score: 222.8 E(): 3.8 e-05%2C 28.8%25 identity in 73 aa overlap gene gene4808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4756 SCO4757 SCO4757 SC6G4.35 SC6G4.35 5168216 5169475 + hypothetical protein SC6G4.35%2C unknown%2C len: 419 aa%3B similar to hypotheti cal protein from Rhizobium meliloti TR:Q52997 (EMBL:L39265) (66 aa%2C partial) opt: 154 z-score: 162.6 E(): 0.086%2C 40.0%25 identity in 50 aa overlap. N-terminus is weakly similar to several sigma factors e.g. CARQ_MYXXA RNA polymerase sigma factor carQ (174 aa)%2C fasta scores%3B opt: 153 z-score: 172. 4 E(): 0.024%2C 29.8%25 identity in 161 aa overlap gene gene4809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4757 SCO4758 SCO4758 SC6G4.36c SC6G4.36c 5169472 5170752 - hypothetical protein SC6G4.36c%2C similar to hypothetical proteins e.g. M. tuberculosis TR:O53284 (EMBL:AL021287) MTV012.52c (358 aa) %2C fasta scores%3B opt: 545 z-score: 329.5 E(): 4.1e-11%2C 36.2%25 identity in 354 aa overlap gene gene4810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4758 SCO4759 SCO4759 SC6G4.37 SC6G4.37 5170780 5171655 + hypothetical protein SC6G4.37%2C probable hypothetical protein%2C len: 264 aa%3B contains possible N-terminal signal sequence. Similar to down stream gene SC6G4.38 (E(): 3.9e-19%2C 38.7%25 identity in 248 aa overlap) gene gene4811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4759 SCO4760 SCO4760 SC6G4.38 SC6G4.38 5171652 5172401 + hypothetical protein SC6G4.38%2C probable hypothetical protein%2C len: 249 aa%3B slight similarity to S. lividans TR:Q54413 (EMBL:M64552) acetyl-xylan esterase precursor (335 aa)%2C fasta scores%3B opt: 16 3 z-score: 197.4 E(): 0.00099%2C 28.9%25 identity in 180 aa overlap. Contains N-terminal signal sequence gene gene4812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4760 SCO4761 SCO4761 groES groES 5172737 5173045 + co-chaperonin GroES 10 kDa chaperonin%3B Cpn10%3B GroES%3B forms homoheptameric ring%3B binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it%3B folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES%3B release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring gene gene4813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4761 SCO4762 SCO4762 groEL groEL 5173179 5174804 + chaperonin GroEL 60 kDa chaperone family%3B promotes refolding of misfolded polypeptides especially under stressful conditions%3B forms two stacked rings of heptamers to form a barrel-shaped 14mer%3B ends can be capped by GroES%3B misfolded proteins enter the barrel where they are refolded when GroES binds%3B many bacteria have multiple copies of the groEL gene which are active under different environmental conditions%3B the B.japonicum protein in this cluster is expressed constitutively%3B in Rhodobacter%2C Corynebacterium and Rhizobium this protein is not essential for growth gene gene4814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4762 SCO4763 SCO4763 SC6G4.41c SC6G4.41c 5175044 5176285 - hypothetical protein SC6G4.41c%2C unknown%2C len: 413 aa gene gene4815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4763 SCO4764 SCO4764 SC6G4.42c SC6G4.42c 5176428 5177201 - dehydrogenase SC6G4.42c%2C probable dehydrogenase%2C len: 257 aa%3B simi lar to many members of the short-chain dehydrogenases/reduc tases family e.g. TR:Q54190 (EMBL:D14040) S. galilaeus keto acyl reductase aknIII (261 aa)%2C fasta scores%3B opt: 350 z-sc ore: 438.4 E(): 3.5e-17%2C 33.5%25 identity in 233 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C Alcohol/oth er dehydrogenases%2C short chain type%2C score 158.00%2C E-value 1.6e-43 gene gene4816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4764 SCO4765 SCO4765 SC6G4.43c SC6G4.43c 5177256 5177957 - hypothetical protein SC6G4.43c%2C unknown%2C len: 233 aa%3B similar to hypothet ical proteins e.g. M. tuberculosis TR:P95151 (EMBL:Z83859) MTCY359.09 (251 aa)%2C fasta scores%3B opt: 716 z-score: 609.7 E(): 1e-26%2C 54.4%25 identity in 215 aa overlap gene gene4817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4765 SCO4766 SCO4766 SC6G4.44 SC6G4.44 5178021 5178941 + transcriptional regulator SC6G4.44%2C probable transcriptional regulator%2C len: 306 aa%3B similar to many members of the lysR family e.g. CYNR_ ECOLI cyn operon transcriptional activator (299 aa)%2C fasta scores%3B opt: 371 z-score: 524.3 E(): 5.8e-22%2C 30.3%25 identity in 307 aa overlap. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature%2C helix-turn-helix motif at aa 18-39 (Score 1603%2C +4.65 SD) and Pfam match to entry PF0 0126 HTH_1%2C Bacterial regulatory helix-loop-helix proteins%2C lysR family%2C score 161.30%2C E-value 1.6e-44 gene gene4818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4766 SCO4767 SCO4767 SC6G4.45c SC6G4.45c 5179007 5179345 - regulatory protein SC6G4.45c%2C probable regulatory protein%2C len: 112 aa%3B similar to TR:Q53963 (EMBL:X62287) S.coelicolor regulatory protein WhiB (87 aa)%2C fasta scores%3B opt: 201 z-score: 352. 1 E(): 2.3e-12%2C 49.3%25 identity in 71 aa overlap gene gene4819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4767 SCO4768 SCO4768 SC6G4.46 SC6G4.46 5179727 5180338 + two-component regulator SC6G4.46%2C probable two-component regulator%2C len: 203 aa%3B similar to many members of the luxR family e.g. DEGU_BACSU transcriptional regulatory protein DegU (229 aa)%2C fasta scores%3B opt: 229 z-score: 546.3 E(): 3.4e-23%2C 30.9%25 identi ty in 223 aa overlap. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature and Pfam matchs to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 108.40%2C E-value 1.4e-28 and to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 65.60%2C E-value 1e-15 gene gene4820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4768 SCO4769 SCO4769 SCD63.01 SCD63.01 5180620 5181207 + RNA polymerase sigma factor SigD Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B this protein is involved in expression of ribosome-associated gene products in stationary phase gene gene4821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4769 SCO4770 SCO4770 guaB guaB 5181347 5182852 + inosine 5' monophosphate dehydrogenase SCD63.02%2C guaB%2C inosine 5' monophosphate dehydrogenase%2C len: 501 aa%3B highly similar to previously sequenced TR:O86844 (EMBL:AJ010601) Streptomyces coelicolor inosine 5' monophosphate dehydrogenase%2C 523 aa%3B fasta scores: opt: 2626 z-score: 2896.3 E(): 0%3B 84.9%25 identity in 509 aa overlap. Contains Pfam matches to entries PF01574 IMPDH_N%2C IMP dehydrogenase / GMP reductase N terminus%2C 2x PF00571 CBS%2C CBS domain and PF00478 IMPDH_C%2C IMP dehydrogenase / GMP reductase C terminus and match to Prosite entry PS00487 IMP dehydrogenase / GMP reductase signature gene gene4822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4770 SCO4771 SCO4771 SCD63.03 SCD63.03 5182993 5184117 + inosine 5-monophosphate dehydrogenase catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate gene gene4823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4771 SCO4772 SCO4772 SCD63.04 SCD63.04 5184449 5185669 + transposase SCD63.04%2C possible transposase%2C len: 406 aa%3B similar to TR:Q9X8Z6 (EMBL:AL078610) Streptomyces coelicolor transposase SCH35.10%2C 407 aa%3B fasta scores: opt: 513 z-score: 604.0 E(): 3.2e-26%3B 29.9%25 identity in 408 aa overlap. Contains Pfam match to entry PF01385 Transposase_2%2C Probable transposase gene gene4824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4772 SCO4773 SCO4773 SCD63.05c SCD63.05c 5185771 5186988 - nucleotide-sugar dehydrogenase SCD63.05c%2C probable nucleotide-sugar dehydrogenase%2C len: 405 aa%3B similar to SW:WECC_ECOLI (EMBL:M87049) Escherichia coli UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (EC 1.1.1.-) WecC%2C 420 aa%3B fasta scores: opt: 565 z-score: 606.3 E(): 2.4e-26%3B 31.7%25 identity in 420 aa overlap. Contains Pfam match to entry PF00984 UDPG_MGDP_dh%2C UDP-glucose/GDP-mannose dehydrogenase family gene gene4825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4773 SCO4774 SCO4774 SCD63.06 SCD63.06 5187291 5188997 + glycerol phosphate dehydrogenase SCD63.06%2C probable glycerol phosphate dehydrogenase%2C len: 568 aa%3B similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD%2C 555 aa%3B fasta scores: opt: 815 z-score: 910.2 E(): 0%3B 32.1%25 identity in 546 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh%2C FAD-dependent glycerol-3-phosphate dehydrogenase and match to Prosite entry PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2 gene gene4826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4774 SCO4775 SCO4775 pkaH pkaH 5189098 5191251 + Ser/Thr protein kinase SCD63.07%2C pkaH%2C Ser/Thr protein kinase%2C len: 717 aa%3B similar to TR:Q9XAI1 (EMBL:AL079348) Streptomyces coelicolor Ser/Thr protein kinase SC66T3.32c%2C 783 aa%3B fasta scores: opt: 570 z-score: 386.8 E(): 4.1e-14%3B 30.6%25 identity in 687 aa overlap and to SW:PKAA_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr protein kinase PkaA (EC 2.7.1.-)%2C 543 aa%3B fasta scores: opt: 543 z-score: 370.9 E(): 3.1e-13%3B 29.8%25 identity in 476 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature and possible hydrophobic membrane spanning region gene gene4827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4775 SCO4776 SCO4776 SCD63.08 SCD63.08 5191425 5194364 + Ser/Thr protein kinase SCD63.08%2C possible Ser/Thr protein kinase%2C len: 979 aa%3B similar to TR:O83032 (EMBL:AB16932) Streptomyces coelicolor protein Ser/Thr kinase PhaD%2C 598 aa%3B blastp scores: Sum P(2) %3D 2.4e-24 Identities %3D 123/403 (30%25)%2C Positives %3D 159/403 (39%25). Contains 2x Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and possible hydrophobic membrane spanning region. High content in alanine%2C glycine and proline residues gene gene4828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4776 SCO4777 SCO4777 pkaD pkaD 5194501 5196300 + protein Ser/Thr kinase SCD63.09%2C pkaD%2C protein Ser/Thr kinase%2C len: 599 aa%3B identical to previously sequenced TR:O83032 (EMBL:AB016932) Streptomyces coelicolor protein Ser/Thr kinase PkaD. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature and possible hydrophobic membrane spanning region gene gene4829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4777 SCO4778 SCO4778 pkaI pkaI 5196394 5197536 + Ser/Thr protein kinase SCD63.10%2C pkaI%2C Ser/Thr protein kinase%2C len: 380 aa%3B similar to TR:CAB50939 (EMBL:AL096849) Streptomyces coelicolor protein Ser/Thr kinase SCI11.13%2C 550 aa%3B fasta scores: opt: 932 z-score: 751.0 E(): 0%3B 45.0%25 identity in 416 aa overlap and to SW:PKAA_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr protein kinase PkaA (EC 2.7.1.-)%2C 543 aa%3B fasta scores: opt: 557 z-score: 454.6 E(): 6.8e-18%3B 33.9%25 identity in 386 aa overlap. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and possible hydrophobic membrane spanning region gene gene4830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4778 SCO4779 SCO4779 pkaJ pkaJ 5197710 5199356 + Ser/Thr protein kinase SCD63.11%2C pkaJ%2C Ser/Thr protein kinase%2C len: 548 aa%3B N-terminal region similar to TR:CAB50939 (EMBL:AL096849) Streptomyces coelicolor protein Ser/Thr kinase SCI11.13%2C 550 aa%3B fasta scores: opt: 1006 z-score: 815.3 E(): 0%3B 56.9%25 identity in 297 aa overlap and to TR:AAD47061 (EMBL:AF159501) Myxococcus xanthus Pkn4%2C 643 aa%3B fasta scores: opt: 639 z-score: 521.3 E(): 1.4e-21%3B 43.6%25 identity in 273 aa overlap and C-terminal similar to TR:Q9WTP4 (EMBL:AB019577) Mus musculus UNC-51-like kinase (ULK) 2%2C Ulk2%2C 1037 aa%3B blastp socres: Sum P(2) %3D 2.6e-24 Identities %3D 89/289 (30%25)%2C Positives %3D 144/289 (49%25). Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature gene gene4831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4779 SCO4780 SCO4780 gabD2 gabD2 5199496 5201109 + succinic semialdehyde dehydrogenase NADP-dependent semialdehyde dehydrogenase%3B part of alternative pathway from alpha-ketoglutarate to succinate gene gene4832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4780 SCO4781 SCO4781 SCD63.13 SCD63.13 5201210 5203018 + cholesterol oxidase SCD63.13%2C possible cholesterol oxidase%2C len: 602 aa%3B similar to TR:Q59530 (EMBL:U00015) Mycobacterium leprae probable cholesterol oxidase precursor (EC 1.1.3.6) ChoD%2C 585 aa%3B fasta scores: opt: 1114 z-score: 1181.0 E(): 0%3B 60.5%25 identity in 583 aa overlapand to SW:CHOD_BREST (EMBL:D00712) Brevibacterium sterolicum cholesterol oxidase precursor (EC 1.1.3.6) ChoD%2C 552 aa%3B fasta scores: opt: 228 z-score: 244.5 E(): 3.4e-06%3B 26.9%25 identity in 576 aa overlap gene gene4833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4781 SCO4782 SCO4782 SCD63.14c SCD63.14c 5203137 5203796 - hypothetical protein SCD63.14c%2C possible integral membrane protein%2C len: 219 aa. Contains possible hydrophobic membrane spanning regions gene gene4834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4782 SCO4783 SCO4783 SCD63.15 SCD63.15 5203840 5204163 + hypothetical protein SCD63.15%2C unknown%2C len: 107 aa gene gene4835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4783 SCO4784 SCO4784 SCD63.16c SCD63.16c 5204510 5204842 - hypothetical protein SCD63.16c%2C hypothetical protein%2C len: 110 aa%3B similar to SW:Y948_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 11.8 kD protein RV0984c%2C MTCY10D7.26%2C 105 aa%3B fasta scores: opt: 195 z-score: 252.8 E(): 1.2e-06%3B 47.2%25 identity in 72 aa overlap gene gene4836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4784 SCO4785 SCO4785 guaA guaA 5205166 5206746 + GMP synthase contains glutamine-hydrolyzing domain and glutamine amidotransferase%3B GMP-binding domain%3B functions to produce GMP from XMP in the IMP pathway gene gene4837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4785 SCO4786 SCO4786 SCD63.18c SCD63.18c 5206750 5207217 - hypothetical protein SCD63.18c%2C unknown%2C len: 155 aa gene gene4838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4786 SCO4787 SCO4787 SCD63.19 SCD63.19 5207363 5208166 + hypothetical protein SCD63.19%2C possible aldolase%2C len: 267 aa%3B similar to SW:ADDA_HUMAN (EMBL:X58141) Homo sapiens erythrocyte adducin alpha subunit AddA%2C 737 aa%3B fasta scores: opt: 422 z-score: 487.2 E(): 1e-19%3B 35.4%25 identity in 240 aa overlap . Contains Pfam match to entry PF00596 Aldolase_II%2C Class II Aldolase and Adducin N-terminal domain gene gene4839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4787 SCO4788 SCO4788 SCD63.20 SCD63.20 5208328 5209623 + ntegral membrane protein SCD63.20%2C possible integral membrane protein%2C len: 431 aa. Contains possible hydrophobic membrane spanning regions gene gene4840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4788 SCO4789 SCO4789 SCD63.21 SCD63.21 5209775 5210290 + hypothetical protein SCD63.21%2C possible integral membrane protein%2C len: 171 aa. Contains possible hydrophobic membrane spanning regions gene gene4841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4789 SCO4790 SCO4790 SCD63.22c SCD63.22c 5210501 5211922 - hypothetical protein SCD63A.01c%2C possible integral membrane protein (fragment)%2C len: >35 aa~SCD63.22c%2C possible integral membrane protein (fragment)%2C len: 171 aa. Contains possible hydrophobic membrane spanning regions gene gene4842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4790 SCO4791 SCO4791 SCD63A.02 SCD63A.02 5212113 5213405 + two-component system sensor kinase SCD63A.02%2C possible two-component system sensor kinase%2C len: 430 aa%3B C-terminal domain similar to TR:CAB51969 (EMBL:AL109661) Streptomyces coelicolor two-component system sensor kinase SC6E10.15c%2C 413 aa%3B fasta scores: opt: 168 z-score: 198.3 E(): 0.0014%3B 32.7%25 identity in 248 aa overlap. Contains possible hydrophobic membrane regions in N-terminal domain gene gene4843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4791 SCO4792 SCO4792 SCD63A.03 SCD63A.03 5213402 5214157 + two-component system DNA-binding response regulator SCD63A.03%2C probable two-component system DNA-binding response regulator%2C len: 251 aa%3B similar to SW:NARL_ECOLI (EMBL:X13360) Escherichia coli nitrate/nitrite response regulator protein NarL%2C 216 aa%3B fasta scores: opt: 428 z-score: 490.1 E(): 7.8e-20%3B 34.1%25 identity in 214 aa overlap and to TR:CAB51968 (EMBL:AL109661) Streptomyces coelicolor two-component system regulator SC6E10.14c%2C 215 aa%3B fasta scores: opt: 517 z-score: 472.3 E(): 9.4e-21%3B 44.3%25 identity in 219 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains also possible helix-turn-helix motif at residues 206..227 (+2.85 SD) gene gene4844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4792 SCO4793 SCO4793 SCD63A.04c SCD63A.04c 5214259 5215302 - hypothetical protein SCD63A.04c%2C probable hypothetical protein%2C len: 347 aa%3B similar to TR:Q9XAQ3 (EMBL:AL078618) Streptomyces coelicolor SCD16A.22%2C 277 aa%3B fasta scores: opt: 409 z-score: 418.8 E(): 7.3e-16%3B 34.8%25 identity in 250 aa overlap%2C to TR:Q9X7Z5 (EMBL:AL049497) Streptomyces coelicolor hypothetical protein SC6G10.09c%2C 347 aa%3B fasta scores: opt: 928 z-score: 800.9 E(): 0%3B 44.2%25 identity in 353 aa overlap and to Streptomyces coelicolor SCD63A.07c%2C 398 aa. Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family and possible N-terminal region signal peptide sequence. Contains also possible colied-coil region at aprox. residues 58..98 gene gene4845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4793 SCO4794 SCO4794 SCD63A.05 SCD63A.05 5215428 5215964 + hypothetical protein SCD63A.05%2C possible integral membrane protein%2C len: 178 aa. Contains possible hydrophobic membrane spanning regions and a TTA leucine codon (codon 57)%2C possible target for bldA regulation gene gene4846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4794 SCO4795 SCO4795 SCD63A.06c SCD63A.06c 5215942 5216958 - hypothetical protein SCD63A.06c%2C possible integral membrane protein%2C len: 338 aa%3B similar to TR:O88074 (EMBL:AL031541) Streptomyces coelicolor integral membrane protein SCI35.39%2C394 aa%3B fasta scores: opt: 142 z-score: 173.6 E(): 0.033%3B 28.0%25 identity in 311 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4795 SCO4796 SCO4796 SCD63A.07c SCD63A.07c 5216985 5218181 - hypothetical protein SCD63A.07c%2C possible hypothetical protein%2C len: 398 aa%3B similar to TR:Q9XAQ3 (EMBL:AL078618) Streptomyces coelicolor hypothetical protein SCD16A.22%2C 277 aa%3B fasta scores: opt: 479 z-score: 430.6 E(): 1.6e-16%3B 39.1%25 identity in 233 aa overlap%2C to TR:Q9X7Z5 (EMBL:AL049497) Streptomyces coelicolor hypothetical protein SC6G10.09c%2C 347 aa%3B fasta scores: opt: 576 z-score: 513.3 E(): 4e-21%3B 41.5%25 identity in 395 aa overlap and to Streptomyces coelicolor SCD63A.04c%2C 347 aa. Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family. Contains also possible coiled-coil regions at aprox. residues 58..98 and 176..242 and possible N-terminal signal peptide sequence gene gene4848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4796 SCO4797 SCO4797 SCD63A.08 SCD63A.08 5218624 5221119 + ATP-dependent DNA helicase II SCD63A.08%2C probable ATP-dependent DNA helicase II%2C len: 831 aa%3B similar to TR:P73465 (EMBL:D90906) Synechocystis sp. DNA helicase II UvrD%2C 793 aa%3B fasta scores: opt: 1417 z-score: 1459.4 E(): 0%3B 40.4%25 identity in 817 aa overlap and to SW:REP_ECOLI (EMBL:M87049) Escherichia coli ATP-dependent DNA helicase Rep%2C 673 aa%3B fasta scores: opt: 824 z-score: 849.5 E(): 0%3B 37.8%25 identity in 661 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase%2C UvrD/REP helicase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4797 SCO4798 SCO4798 SCD63A.09c SCD63A.09c 5221209 5222906 - peptidase SCD63A.09c%2C possible peptidase%2C len: 565 aa%3B C-terminal region similar to SW:LSTP_STAST (EMBL:X06121) Staphylococcus staphylolyticus lysostaphin precursor (EC 3.4.24.75) Lss%2C 480 aa%3B fasta scores: opt: 299 z-score: 293.2 E(): 7.2e-09%3B 25.0%25 identity in 368 aa overlap and to TR:O50513 (EMBL:AL009204) Streptomyces coelicolor hypothetical protein SC9B10.06%2C 250 aa%3B fasta scores: opt: 458 z-score: 352.7 E(): 4.3e-14%3B 41.6%25 identity in 231 aa overlap. Contains Pfam match to entry PF01551 Peptidase_M37%2C Peptidase family M23/M37 gene gene4850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4798 SCO4799 SCO4799 SCD63A.10c SCD63A.10c 5223103 5224098 - lipase SCD63A.10c%2C possible lipase%2C len: 331 aa%3B similar to SW:LIP_BACSU (EMBL:M74010) Bacillus subtilis lipase precursor (EC 3.1.1.3) LipA%2C 212 aa%3B fasta scores: opt: 188 z-score: 190.5 E(): 0.0038%3B 26.5%25 identity in 211 aa overlap and to TR:AAF11628 (EMBL:AE002044) Deinococcus radiodurans lipase%2C %2C 237 aa%3B fasta scores: opt: 309 z-score: 302.6 E(): 2.2e-09%3B 32.0%25 identity in 200 aa overlap. Contains match to Prosite entry PS00120 Lipases%2C serine active site and possible N-terminal region signal peptide sequence gene gene4851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4799 SCO4800 SCO4800 icmB icmB 5224492 5224908 + isobutyryl-CoA mutase%2C small subunit SCD63A.11%2C icmB%2C isobutyryl CoA mutase%2C small subunit%2C len: 138 aa%3B almost identical to TR:CAB59633 (EMBL:AJ246005) Streptomyces cinnamonensis isobutyryl CoA mutase%2C small subunit (EC 5.4.99.13) IcmB%2C 136 aa%3B fasta scores: opt: 803 z-score: 972.5 E(): 0%3B 92.5%25 identity in 134 aa overlap and highly similar to TR:CAB71846 (EMBL:138667) Streptomyces coelicolor probable isobutyryl-CoA mutase%2C small subunit SC3D9.01%2C 159 aa%3B fasta scores: opt: 594 z-score: 628.1 E(): 2e-29%3B 70.6%25 identity in 126 aa overlap gene gene4852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4800 SCO4801 SCO4801 SCD63A.12c SCD63A.12c 5225006 5226826 - hypothetical protein SCD63A.12c%2C unknown%2C len: 606 aa. High content in alanine amino acid residues gene gene4853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4801 SCO4802 SCO4802 SCD63A.13c SCD63A.13c 5226862 5228001 - hypothetical protein SCD63A.13c%2C unknown%2C len: 379 aa gene gene4854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4802 SCO4803 SCO4803 SCD63A.14 SCD63A.14 5228085 5229206 + hypothetical protein SCD63A.14%2C conserved hypothetical protein%2C len: 373 aa%3B similar to TR:CAB61595 (EMBL:AL133210) Streptomyces coelicolor hypothetical 41.5 kD protein SCG11A.14%2C 389 aa%3B fasta scores: opt: 774 z-score: 864.5 E(): 0%3B 46.5%25 identity in 376 aa overlap and to SW:YEHL_ECOLI (EMBL:U00007) Escherichia coli hypothetical 42.4 kD protein in MolR-BglX intergenic region YehL%2C 384 aa%3B fasta scores: opt: 771 z-score: 861.2 E(): 0%3B 41.2%25 identity in 359 aa overlap gene gene4855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4803 SCO4804 SCO4804 SCD63A.15 SCD63A.15 5229309 5231756 + hypothetical protein SCD63A.15%2C hypothetical protein%2C len: 815 aa%3B similar to TR:CAB61596 (EMBL:AL133210) Streptomyces coelicolor hypothetical 135.7 kD protein SCG11A.15%2C 1320 aa%3B fasta scores: opt: 340 z-score: 332.5 E(): 4.6e-11%3B 30.4%25 identity in 883 aa overlap gene gene4856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4804 SCO4805 SCO4805 SCD63A.16 SCD63A.16 5231927 5233081 + hypothetical protein SCD63A.16%2C hypothetical protein%2C len: 348 aa%3B similar to SW:YEHP_ECOLI (EMBL:) Escherichia coli hypothetical 42.1 kD protein in MolR-BglX intergenic region YehP%2C 378 aa%3B fasta scores: opt: 721 z-score: 816.7 E(): 0%3B 35.7%25 identity in 378 aa overlap gene gene4857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4805 SCO4806 SCO4806 SCD63A.17 SCD63A.17 5233252 5234196 + hypothetical protein SCD63A.17%2C possible hypothetical protein%2C len: 314 aa. Contains possible N-terminal region signal peptide sequence gene gene4858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4806 SCO4807 SCO4807 SCD63A.18 SCD63A.18 5234328 5234783 + hypothetical protein SCD63A.18%2C unknown%2C len: 151 aa. Doubtful CDS gene gene4859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4807 SCO4808 SCO4808 sucC sucC 5234993 5236177 + succinyl-CoA synthetase subunit beta catalyzes the interconversion of succinyl-CoA and succinate gene gene4860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4808 SCO4809 SCO4809 SCD63A.20 SCD63A.20 5236206 5237090 + succinyl-CoA synthetase subunit alpha Catalyzes the only substrate-level phosphorylation in the TCA cycle gene gene4861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4809 SCO4810 SCO4810 SCD63A.21c SCD63A.21c 5237203 5238231 - hypothetical protein SCD63A.21c%2C hypothetical protein%2C len: 342 aa%3B similar to TR:Q9Z9I2 (EMBL:AB024056) Streptomyces fradiae unknown protein%2C 306 aa%3B fasta scores: opt: 645 z-score: 632.8 E(): 8.7e-28%3B 44.5%25 identity in 281 aa overlap gene gene4862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4810 SCO4811 SCO4811 SCD63A.22 SCD63A.22 5238424 5240100 + hypothetical protein SCD63A.22%2C possible integral membrane protein%2C len: 558 aa. Contains possible hydrophobic membrane spanning regions gene gene4863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4811 SCO4812 SCO4812 SCD63A.23c SCD63A.23c 5240239 5241036 - hypothetical protein SCD63A.23c%2C possible integral membrane protein%2C len: 265 aa. Contains possible hydrophobic membrane spanning regions gene gene4864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4812 SCO4813 SCO4813 purN purN 5241331 5241978 + phosphoribosylglycinamide formyltransferase glycinamide ribonucleotide transformylase%3B GAR Tfase%3B catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate%3B PurN requires formyl folate for the reaction unlike PurT which uses formate gene gene4865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4813 SCO4814 SCO4814 purH purH 5241975 5243546 + bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase involved in de novo purine biosynthesis gene gene4866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4814 SCO4815 SCO4815 SCD63A.26c SCD63A.26c 5243963 5244607 - hypothetical protein SCD63A.26c%2C possible hypothetical protein%2C len: 214 aa. Contains possible N-terminal signal peptide sequence gene gene4867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4815 SCO4816 SCO4816 SC2A6.01c SC2A6.01c 5244609 5247029 - hypothetical protein SC2A6.01c%2C hypothetical protein (fragment)%2C len: >232 aa%3B similar to TR:O34320 (EMBL:AJ222587) Bacillus subtilis YkuG protein%2C 760 aa%3B fasta scores: opt: 439 z-score: 541.2 E(): 1.2e-22%3B 37.1%25 identity in 229 aa overlap~SCD63A.27c%2C hypothetical protein (fragment)%2C len: >605 aa%3B similar to TR:O34320 (EMBL:AJ222587) Bacillus subtilis YkuG protein%2C 760 aa%3B fasta scores: opt: 961 z-score: 1162.8 E(): 0%3B 34.4%25 identity in 596 aa overlap gene gene4868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4816 SCO4817 SCO4817 SC2A6.02c SC2A6.02c 5247215 5248573 - Ser/Thr protein kinase SC2A6.02c%2C possible Ser/Thr protein kinase%2C len: 452 aa%3B similar to TR:CAB82017 (EMBL:AL161755) Streptomyces coelicolor Ser/Thr protein kinase SCD63.10%2C 380 aa%3B fasta scores: opt: 297 z-score: 312.5 E(): 6.3e-10%3B 28.8%25 identity in 379 aa overlap and to Streptomyces coelicolor SC2A6.05c%2C 712 aa%3B fasta scores: opt: 1410 z-score: 1253.9 E(): 0%3B 68.7%25 identity in 339 aa overlap. Contains Pfam matches to entries PF00069 pkinase%2C Eukaryotic protein kinase domain and PF01471 PG_binding_1%2C peptidoglycan binding domain. Contains also possible hydrophobic membrane spanning regions gene gene4869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4817 SCO4818 SCO4818 SC2A6.03c SC2A6.03c 5248570 5249310 - hypothetical protein SC2A6.03c%2C unknown%2C len: 246 aa%3B similar to Streptomyces coelicolor SC2A6.06c%2C 243 aa%3B fasta scores: opt: 1097 z-score: 1146.8 E(): 0%3B 67.6%25 identity in 244 aa overlap gene gene4870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4818 SCO4819 SCO4819 SC2A6.04c SC2A6.04c 5249522 5249992 - hypothetical protein SC2A6.04c%2C possible hypothetical protein%2C len: 156 aa. Contains possible N-terminal region signal peptide sequence gene gene4871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4819 SCO4820 SCO4820 SC2A6.05c SC2A6.05c 5250091 5252229 - Ser/Thr protein kinase SC2A6.05c%2C possible Ser/Thr protein kinase%2C len: 712 aa%3B C-terminal region similar to TR:O53510 (EMBL:AL021957) Mycobacterium tuberculosis Ser/Thr protein kinase MTV021.09%2C 399 aa%3B fasta scores: opt: 289 z-score: 239.4 E(): 7.5e-06%3B 30.6%25 identity in 340 aa overlap and to Streptomyces coelicolor SC2A6.02c%2C 452 aa%3B fasta scores: opt: 1410 z-score: 964.7 E(): 0%3B 68.7%25 identity in 339 aa overlap. Contains 2 Pfam matches to entry PF00069 pkinase%2C Eukaryotic protein kinase domain. Contains also possible hydrophobic membrane spanning regions%2C 3x degenerate repeat: (T/H)GTGTGT(8)AHPA(K/E)GDTD(N/D)PG(16) and 2x degenerate repeat: PSRA(Q/H)TDTAHPAEGDTD(D/N)PGHTSGNGTTGTDGT(R/G)S(7) gene gene4872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4820 SCO4821 SCO4821 SC2A6.06c SC2A6.06c 5252226 5252957 - hypothetical protein SC2A6.06c%2C unknown%2C len: 243 aa%3B similar to Streptomyces coelicolor SC2A6.03c%2C 246 aa%3B fasta scores: opt: 1097 z-score: 1069.3 E(): 0%3B 67.6%25 identity in 244 aa overlap gene gene4873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4821 SCO4822 SCO4822 SC2A6.07c SC2A6.07c 5253098 5253685 - hypothetical protein SC2A6.07c%2C possible integral membrane protein%2C len: 195 aa. Contains possible hydrophobic membrane spanning regions gene gene4874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4822 SCO4823 SCO4823 SC2A6.08 SC2A6.08 5253808 5253984 + hypothetical protein SC2A6.08%2C unknown%2C len: 58 aa. Contains a TTA leucine codon%2C possible target for bldA regulation gene gene4875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4823 SCO4824 SCO4824 folD folD 5253981 5254835 + bifunctional 5%2C10-methylene-tetrahydrofolate dehydrogenase/ 5%2C10-methylene-tetrahydrofolate cyclohydrolase catalyzes the formation of 5%2C10-methenyltetrahydrofolate from 5%2C10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5%2C10-methenyltetrahydrofolate gene gene4876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4824 SCO4825 SCO4825 SC2A6.10 SC2A6.10 5254825 5255361 + hypothetical protein SC2A6.10%2C possible integral membrane protein%2C len: 178 aa%3B similar to TR:O32878 (EMBL:Z98271) Mycobacterium leprae hypothetical 9.6 kD protein MLCB1779.16c%2C 91 aa%3B fasta scores: opt: 148 z-score: 174.2 E(): 0.032%3B 27.5%25 identity in 80 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4825 SCO4826 SCO4826 SC2A6.11 SC2A6.11 5255658 5257154 + hypothetical protein SC2A6.11%2C possible membrane protein%2C len: 498 aa. Contains 5x degenerate repeat: (G/D)AY(G/D)(E/G)-(3) and possible hydrophobic membrane spanning region gene gene4878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4826 SCO4827 SCO4827 mdh mdh 5257517 5258506 + malate dehydrogenase catalyzes the oxidation of malate to oxaloacetate gene gene4879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4827 SCO4828 SCO4828 gbsA gbsA 5258735 5260264 + betaine aldehyde dehydrogenase SC2A6.13%2C gbsA%2C betaine aldehyde dehydrogenase%2C len: 509 aa%3B highly similar to SW:DHAB_BACSU (EMBL:U47861) Bacillus subtilis betaine aldehyde dehydrogenase (EC 1.2.1.8) GsbA%2C 490 aa%3B fasta scores: opt: 1874 z-score: 2114.6 E(): 0%3B 56.0%25 identity in 495 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family and matches to Prosite entries PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site gene gene4880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4828 SCO4829 SCO4829 SC2A6.14 SC2A6.14 5260321 5261853 + oxidoreductase SC2A6.14%2C probable oxidoreductase%2C len: 510 aa%3B similar to SW:ALKJ_PSEOL (EMBL:X65936) Pseudomonas oleovorans alcohol dehydrogenase [acceptor] (EC 1.1.99.-) AlkJ%2C 558 aa%3B fasta scores: opt: 474 z-score: 541.0 E(): 1.2e-22%3B 31.1%25 identity in 541 aa overlap. Contains Pfam match to entry PF00732 GMC_oxred%2C GMC oxidoreductases and match to Prosite entry PS00624 GMC oxidoreductases signature 2 gene gene4881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4829 SCO4830 SCO4830 SC2A6.15 SC2A6.15 5261850 5263034 + glycine/betaine ABC transporter ATP-binding protein SC2A6.15%2C probable glycine/betaine ABC transport system ATP-binding protein%2C len: 394 aa%3B similar to SW:OPAA_BACSU (EMBL:U17292) Bacillus subtilis glycine/betaine transport ATP-binding protein OpuAa%2C 418 aa%3B fasta scores: opt: 1015 z-score: 1043.6 E(): 0%3B 48.5%25 identity in 338 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4830 SCO4831 SCO4831 SC2A6.16 SC2A6.16 5263034 5264980 + glycine/betaine ABC transporter integral membrane protein SC2A6.16%2C probable glycine/betaine ABC transport system integral membrane protein%2C len: 648 aa%3B N-terminal domain similar to SW:OPAB_BACSU (EMBL:U17292) Bacillus subtilis glycine/betaine transport system permease OpuAb aa%3B fasta scores: opt: 662 z-score: 724.1 E(): 7.5e-33%3B 38.7%25 identity in 269 aa overlap and C-terminal domain similar to TR:Q9RR45 (EMBL:AF039835) Listeria monocytogenes glycine/betaine membrane transport protein GbuB%2C 282 aa%3B fasta scores: opt: 594 z-score: 650.5 E(): 9.5e-29%3B 36.5%25 identity in 263 aa overlap. Contains 2x Pfam matches to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene4883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4831 SCO4832 SCO4832 SC2A6.17 SC2A6.17 5264982 5265950 + glycine/betaine-binding lipoprotein SC2A6.17%2C possible glycine/betaine-binding lipoprotein%2C len: 322 aa%3B similar to SW:PROX_ECOLI (EMBL:M24856) Escherichia coli glycine/betaine-binding periplasmic protein precursor ProX or ProU%2C 330 aa%3B fasta scores: opt: 112 z-score: 137.8 E(): 3.4%3B 21.8%25 identity in 325 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4832 SCO4833 SCO4833 SC2A6.18c SC2A6.18c 5265954 5266685 - phosphorylmutase SC5G8.01c%2C partial CDS%2C possible phosphorylmutase%2C len: >101 aa%3B similar to many e.g. SW:P11435 (CPPM_STRHY) carboxyvinyl-carboxyphosphonate phosphorylmutase from Streptomyces hygroscopicus (294 aa) fasta scores%3B opt: 185%2C z-score: 234.7%2C E(): 1.3e-05%2C 43.0%25 identity in 93 aa overlap.~SC2A6.18c%2C possible transferase (fragment)%2C len: >172 aa%3B similar to C-terminal part of SW:CPPM_BACSU (EMBL:D84432) Bacillus subtilis carboxyvinyl-carboxyphosphonate phosphorylmutase (EC 2.7.8.23) YqiQ%2C 301 aa%3B fasta scores: opt: 158 z-score: 187.0 E(): 0.0062%3B 31.0%25 identity in 116 aa overlap gene gene4885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4833 SCO4834 SCO4834 SC5G8.02c SC5G8.02c 5266682 5267128 - hypothetical protein SC5G8.02c%2C conserved hypothetical protein%2C len: 148 aa%3B similar to many eg. TR:P96684 (EMBL:AB001488) hypothetical protein from Bacillus subtilis (147 aa) fasta scores%3B opt: 329%2C z-score: 442.4%2C E(): 3.5e-17%2C 46.7%25 identity in 105 aa overlap and TR:CAB56729 (EMBL:AL121600) hypothetical protein from Streptomyces coelicolor (173 aa) fasta scores%3B opt: 298%2C z-score: 400.8%2C E(): 7.2e-15%2C 38.9%25 identity in 149 aa overlap. Also similar to neighbouring CDS 03c fasta scores%3B opt: 530%2C z-score: 623.7%2C E(): 3.2e-29%2C 62.3%25 identity in 138 aa overlap gene gene4886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4834 SCO4835 SCO4835 SC5G8.03c SC5G8.03c 5267125 5267634 - hypothetical protein SC5G8.03c%2C conserved hypothetical protein%2C len: 169aa%3B similar to many eg. TR:P96684 (EMBL:AB001488) hypothetical protein from Bacillus subtilis (147 aa) fasta scores%3B opt: 386%2C z-score: 504.8%2C E(): 1.2e-20%2C 42.6%25 identity in 136 aa overlap and TR:CAB66282 (EMBL:AL136519) hypothetical protein from Streptomyces coelicolor (161 aa) fasta scores%3B opt: 324%2C z-score: 425.2%2C E(): 3.2e-16%2C 45.0%25 identity in 129 aa overlap. Also similar to neighbouring CDS SC5G8.02c fasta scores%3B opt: 530%2C z-score: 667.2%2C E(): 1.2e-31%2C 62.3%25 identity in 138 aa overlap gene gene4887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4835 SCO4836 SCO4836 SC5G8.04 SC5G8.04 5267682 5269070 + GntR family transcriptional regulator SC5G8.04%2C possible gntR-family regulator%2C len: 462 aa%3B similar to many proposed regulators eg. TR:AAF01064 (EMBL:AF189258) transcriptional regulator (fragment) from Streptomyces venezuelae (507 aa) fasta scores%3B opt: 1010%2C z-score: 1115.6%2C E(): 0%2C 45.2%25 identity in 389 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. gene gene4888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4836 SCO4837 SCO4837 glyA glyA 5269286 5270731 + serine hydroxymethyltransferase catalyzes the reaction of glycine with 5%2C10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate gene gene4889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4837 SCO4838 SCO4838 SC5G8.06c SC5G8.06c 5270746 5271402 - hypothetical protein SC5G8.06c%2C unknown%2C len: 218aa gene gene4890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4838 SCO4839 SCO4839 SC5G8.07 SC5G8.07 5271519 5272538 + tryptophanyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene4891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4839 SCO4840 SCO4840 SC5G8.08 SC5G8.08 5272715 5273293 + hypothetical protein SC5G8.08%2C possible hypothetical protein%2C len: 339aa%3B N-terminal similar to many eg. TR:Q45633 (EMBL:L13418) maltose permease from Bacillus stearothermophilus (314 aa) fasta scores%3B opt: 155%2C z-score: 191.9%2C E(): 0.0031%2C 31.5%25 identity in 127 aa overlap. Contains a possible cleavable N-terminal signal sequence. gene gene4892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4840 SCO4841 SCO4841 SC5G8.09c SC5G8.09c 5273376 5274146 - short-chain dehydrogenase SC5G8.09c%2C possible short-chain dehydrogenase%2C len: 256aa%3B similar to many proposed oxidoreductases eg. similar to many eg. SW:P43168 (YMP3_STRCO) hypothetical oxidoreductase from Streptomyces coelicolor (251 aa) fasta scores%3B opt: 1120%2C z-score: 1262.0%2C E(): 0%2C 73.6%25 identity in 250 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene4893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4841 SCO4842 SCO4842 SC5G8.10c SC5G8.10c 5274166 5275539 - oxidoreductase SC5G8.10c%2C possible oxidoreductase%2C len: 457aa%3B similar to many of undefined function eg. SW:P43167 (YMP4_STRCO) hypothetical protein from Streptomyces coelicolor (367 aa)fasta scores%3B opt: 1349%2C z-score: 1513.9%2C E(): 0%2C 58.1%25 identity in 375 aa overlap. Contains Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain. gene gene4894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4842 SCO4843 SCO4843 SC5G8.11 SC5G8.11 5275682 5276191 + hypothetical protein SC5G8.11%2C possible integral membrane protein%2C len: 169aa%3B similar to many of undefined function eg. TR:O53584 (EMBL:AL022076) hypothetical protein from Mycobacterium tuberculosis (165 aa) fasta scores%3B opt: 324%2C z-score: 386.8%2C E(): 4.3e-14%2C 41.5%25 identity in 159 aa overlap. Contains Pfam match to entry PF01569 PAP2%2C PAP2 superfamily and possible membrane-spanning hydrophobic regions. gene gene4895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4843 SCO4844 SCO4844 SC5G8.12 SC5G8.12 5276184 5277152 + phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate gene gene4896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4844 SCO4845 SCO4845 SC5G8.13 SC5G8.13 5277146 5277619 + hypothetical protein SC5G8.13%2C possible integral membrane protein%2C len: 157aa%3B similar to many eg. SW:P72055 (Y1I9_MYCTU) hypothetical protein from Mycobacterium tuberculosis (121 aa) fasta scores%3B opt: 139%2C z-score: 176.2%2C E(): 0.023%2C 31.7%25 identity in 126 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene4897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4845 SCO4846 SCO4846 SC5G8.14 SC5G8.14 5277574 5278539 + hypothetical protein SC5G8.14%2C possible integral membrane protein%2C len: 321aa%3B weakly similar to many eg. SW:P45417 (YHJD_ERWCH) hypothetical protein from Erwinia chrysanthemi (328 aa) fasta scores%3B opt: 305%2C z-score: 344.6%2C E(): 9.7e-12%2C 29.7%25 identity in 283 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene4898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4846 SCO4847 SCO4847 SC5G8.15c SC5G8.15c 5278487 5279761 - D-alanyl-D-alanine carboxypeptidase SC5G8.15c%2C possible D-alanyl-D-alanine carboxypeptidase%2C len: 455 aa%3B similar to many e.g. TR:O53380 (EMBL:AL021841) proposed penicillin-binding protein from Mycobacterium tuberculosis (405 aa) fasta scores%3B opt: 392%2C z-score: 369.1%2C E(): 4.2e-13%2C 31.7%25 identity in 439 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11%2C D-alanyl-D-alanine carboxypeptidase. Position of translational start uncertain. gene gene4899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4847 SCO4848 SCO4848 SC5G8.16 SC5G8.16 5279853 5280092 + hypothetical protein SC5G8.16%2C possible integral membrane protein%2C len: 79aa%3B contains possible membrane-spanning hydrophobic regions. Position of translational start uncertain%2C possible alternative start at 13619. gene gene4900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4848 SCO4849 SCO4849 SC5G8.17 SC5G8.17 5280147 5281457 + hypothetical protein SC5G8.17%2C possible integral membrane protein%2C len: 436 aa%3B N-terminal region contains possible membrane-spanning hydrophobic regions while the remainder is similar to many hypothetical proteins e.g. TR:Q9ZM43 (EMBL:AE001473) from Helicobacter pylori J99 (370 aa) fasta scores%3B opt: 596%2C z-score: 590.7%2C E(): 1.9e-25%2C 37.4%25 identity in 273 aa overlap gene gene4901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4849 SCO4850 SCO4850 SC5G8.18c SC5G8.18c 5281448 5282203 - TetR family transcriptional regulator SC5G8.18c%2C possible tetR-family transcriptional regulator%2C len: 251 aa%3B N-terminal region similar to many e.g. TR:CAB53315 (EMBL:AL109974) tetR-family transcriptional regulator from Streptomyces coelicolor (203 aa) fasta scores%3B opt: 190%2C z-score: 242.1%2C E(): 5e-06%2C 35.0%25 identity in 103 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif 40..61 aa gene gene4902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4850 SCO4851 SCO4851 SC5G8.19c SC5G8.19c 5282215 5282703 - hypothetical protein SC5G8.19c%2C unknown%2C len: 162aa gene gene4903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4851 SCO4852 SCO4852 SC5G8.20c SC5G8.20c 5282708 5283115 - hypothetical protein SC5G8.20c%2C possible integral membrane protein%2C len: 135 aa. Contains possible hydrophobic membrane spanning regions gene gene4904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4852 SCO4853 SCO4853 SC5G8.21c SC5G8.21c 5283201 5283611 - hypothetical protein SC5G8.21c%2C unknown%2C len: 136 aa%3B weakly similar to other hypothetical proteins eg. TR:AAF12497 (EMBL:AE001863) from Deinococcus radiodurans (117 aa) fasta scores%3B opt: 109%2C z-score: 149.3%2C E(): 0.74%2C 26.1%25 identity in 111 aa overlap. gene gene4905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4853 SCO4854 SCO4854 SC5G8.22c SC5G8.22c 5283653 5284273 - hypothetical protein SC5G8.22c%2C possible integral membrane protein%2C len: 206aa%3B weakly similar to many eg. TR:P72920 (EMBL:D90901) hypothetical protein from Synechocystis sp. (strain PCC 6803) (181 aa) fasta scores%3B opt: 183%2C z-score: 238.4%2C E(): 8e-06%2C 28.8%25 identity in 146 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene4906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4854 SCO4855 SCO4855 sdhB sdhB 5284439 5285212 - succinate dehydrogenase iron-sulfur subunit part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers)%3B SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556%3B SdhC binds ubiquinone%3B oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol%3B the catalytic subunits are similar to fumarate reductase gene gene4907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4855 SCO4856 SCO4856 sdhA sdhA 5285212 5286966 - succinate dehydrogenase flavoprotein subunit part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers)%3B SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556%3B SdhC binds ubiquinone%3B oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol gene gene4908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4856 SCO4857 SCO4857 SC5G8.25c SC5G8.25c 5286986 5287468 - succinate dehydrogenase membrane subunit SC5G8.25c%2C dhsD%2C possible succinate dehydrogenase membrane subunit%2C len: 160 aa%3B similar to TR:O53369 (EMBL:AL021841) membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (144 aa) fasta scores%3B opt: 553%2C z-score: 702.9%2C E(): 1.1e-31%2C 58.9%25 identity in 141 aa overlap. Also weakly similar to SW:P10445 (DHSD_ECOLI) succinate dehydrogenase hydrophobic membrane anchor protein from Escherichia coli (115 aa) fasta scores%3B opt: 126%2C z-score: 172.2%2C E(): 0.039%2C 23.5%25 identity in 115 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match to entry PF01127 Sdh_cyt%2C Succinate dehydrogenase cytochrome b subunit. gene gene4909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4857 SCO4858 SCO4858 SC5G8.26c SC5G8.26c 5287474 5287854 - succinate dehydrogenase membrane subunit SC5G8.26c%2C dhsC%2C possible succinate dehydrogenase membrane subunit%2C len: 126aa%3B similar to many eg. TR:O53368 (EMBL:AL021841) membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores%3B opt: 484%2C z-score: 649.2%2C E(): 1e-28%2C 65.7%25 identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores%3B opt: 121%2C z-score: 173.9%2C E(): 0.031%2C 29.6%25 identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt%2C Succinate dehydrogenase cytochrome b subunit. gene gene4910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4858 SCO4859 SCO4859 SC5G8.27c SC5G8.27c 5288036 5288587 - OHCU decarboxylase SC5G8.27c%2C unknown%2C len: 183 aa%3B similar to TR:Q9Z593 (EMBL:AL035478) hypothetical protein from Streptomyces coelicolor (191 aa) fasta scores%3B opt: 164%2C z-score: 195.7%2C E(): 0.0019%2C 32.6%25 identity in 187 aa overlap. gene gene4911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4859 SCO4860 SCO4860 SC5G8.28 SC5G8.28 5288869 5290443 + hydrolase SCK20.01%2C probable hydrolase (fragment)%2C len: >465 aa%3B similar to C-terminal region of SW:HEXA_DICDI (EMBL:J04065) Dictyostelium discoideum beta-hexosaminidase A precursor (EC 3.2.1.52) NagA%2C 532 aa%3B fasta scores: opt: 343 z-score: 387.7 E(): 4.6e-14%3B 25.4%25 identity in 393 aa overlap. Contains Pfam match to entry PF00728 Glyco_hydro_20%2C Glycosyl hydrolase family 20~SC5G8.28%2C partial CDS%2C possible hypothetical protein%2C len: >94aa%3B contains a possible cleavable N-terminal signal sequence. gene gene4912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4860 SCO4861 SCO4861 SCK20.02 SCK20.02 5290562 5291107 + hypothetical protein SCK20.02%2C unknown%2C len: 181 aa gene gene4913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4861 SCO4862 SCO4862 SCK20.03 SCK20.03 5291195 5291764 + hypothetical protein SCK20.03%2C unknown%2C len: 189 aa gene gene4914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4862 SCO4863 SCO4863 SCK20.04 SCK20.04 5291932 5292354 + hypothetical protein SCK20.04%2C unknown%2C len: 140 aa gene gene4915 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4863 SCO4864 SCO4864 SCK20.05 SCK20.05 5292421 5293098 + ECF sigma factor SCK20.05%2C possible ECF sigma factor%2C len: 225 aa%3B similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor%2C 264 aa%3B fasta scores: opt: 296 z-score: 342.7 E(): 1.5e-11%3B 34.0%25 identity in 212 aa overlap and to Streptomyces coelicolor ECF sigma factor SCK20.07%2C 220 aa%3B fasta scores: opt: 671 z-score: 656.4 E(): 6.9e-31%3B 59.5%25 identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene4916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4864 SCO4865 SCO4865 SCK20.06 SCK20.06 5293095 5294015 + hypothetical protein SCK20.06%2C unknown%2C len: 306 aa. High G+C content (82.13%25) gene gene4917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4865 SCO4866 SCO4866 SCK20.07 SCK20.07 5294399 5295061 + ECF sigma factor SCK20.07%2C possible ECF sigma factor%2C len: 220 aa%3B similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor%2C 264 aa%3B fasta scores: opt: 280 z-score: 329.1 E(): 8.5e-11%3B 31.9%25 identity in 182 aa overlap and to Streptomyces coelicolor ECF sigma factor SCK20.05%2C 225 aa%3B fasta scores: opt: 671 z-score: 614.8 E(): 1.4e-28%3B 59.5%25 identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene4918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4866 SCO4867 SCO4867 SCK20.08 SCK20.08 5295061 5296242 + hypothetical protein SCK20.08%2C possible membrane protein%2C len: 393 aa. Contains possible hydrophobic membrane spanning regions and 2x degenerate repeat at C-terminal region: PHHP(A/D)R gene gene4919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4867 SCO4868 SCO4868 SCK20.09c SCK20.09c 5296485 5297330 - lipoprotein SCK20.09c%2C possible lipoprotein%2C len: 281 aa%3B similar to TR:CAC14938 (EMBL:AL449216) Streptomyces coelicolor hypothetical protein 3SC5B7.14c%2C 231 aa%3B fasta scores: opt: 330 z-score: 353.2 E(): 3.9e-12%3B 35.3%25 identity in 218 aa overlap. Contains Pfam match to entry PF01471 PG_binding_1%2C peptidoglycan binding domain and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene4920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4868 SCO4869 SCO4869 mutA2 mutA2 5297557 5299161 + methylmalonyl CoA mutase SCK20.10%2C mutA2%2C methylmalonyl CoA mutase%2C len: 534 aa%3B highly similar to SW:MUTA_HUMAN (EMBL:M65131) Homo sapiens methylmalonyl CoA mutase mitochondrial precursor (EC 5.4.99.2) Mut%2C 750 aa%3B fasta scores: opt: 1707 z-score: 1912.4 E(): 0%3B 49.6%25 identity in 534 aa overlap and almost identical to TR:Q9L1V3 (EMBL:AL138668) Streptomyces coelicolor methylmalonyl CoA mutase mutA SC4A9.09%2C 531 aa%3B fasta scores: opt: 3319 z-score: 3721.0 E(): 0%3B 97.0%25 identity in 528 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase%2C Methylmalonyl-CoA mutase gene gene4921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4869 SCO4870 SCO4870 SCK20.11c SCK20.11c 5299181 5300632 - hypothetical protein SCK20.11c%2C probable monooxygenase%2C len: 483 aa%3B similar to TR:P95598 (EMBL:U56415) Corynebacterium equii rifampin monooxygenase Iri%2C 479 aa%3B fasta scores: opt: 691 z-score: 714.1 E(): 3.1e-32%3B 35.0%25 identity in 488 aa overlap and to TR:O86481 (EMBL:AJ007932) Streptomyces argillaceus oxygenase MtmOII%2C 531 aa%3B fasta scores: opt: 590 z-score: 609.9 E(): 1.9e-26%3B 33.3%25 identity in 520 aa overlap. Contains Pfam match to entry PF01494 FAD_binding_3%2C FAD binding domain and match PF01360 Monooxygenase%2C Monooxygenase gene gene4922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4870 SCO4871 SCO4871 SCK20.12 SCK20.12 5300705 5301355 + TetR family transcriptional regulator SCK20.12%2C probable tetR-family transcriptional regulator%2C len: 216 aa%3B similar to SW:TER1_ECOLI (EMBL:X61367) Escherichia coli tetracycline repressor protein class A TetR%2C 216 aa%3B fasta scores: opt: 437 z-score: 544.2 E(): 8.9e-23%3B 43.2%25 identity in 199 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 30..51 (+5.12 SD) gene gene4923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4871 SCO4872 SCO4872 SCK20.13c SCK20.13c 5301340 5302356 - hypothetical protein SCK20.13c%2C unknown%2C len: 338 aa gene gene4924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4872 SCO4873 SCO4873 SCK20.14c SCK20.14c 5302468 5303406 - hypothetical protein SCK20.14c%2C unknown%2C len: 312 aa gene gene4925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4873 SCO4874 SCO4874 SCK20.15 SCK20.15 5303719 5306604 + hypothetical protein SCK20.15%2C possible integral membrane protein%2C len: 961 aa. Contains match to Prosite entry PS01125 ROK family signature. Also contains 4x degenerate repeat: DRA(S/A)G and possible hydrophobic membrane spanning regions gene gene4926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4874 SCO4875 SCO4875 2SCK8.01 2SCK8.01 5306624 5307574 + sugar transferase 2SCK8.01%2C probable sugar transferase (fragment)%2C len: >256 aa%3B similar to SW:GTRB_BPSFX (EMBL:AF056939) Bacteriophage SfX (Shigella flexneri bacteriophage X) bactoprenol glucosyl transferase (EC 2.4.1.*) GtrB%2C 305 aa%3B fasta scores: opt: 659 z-score: 787.3 E(): 0%3B 42.3%25 identity in 246 aa overlap and to middle part of TR:O86666 (EMBL:AL031182) Streptomyces coelicolor sugar transferase SC4A2.10c%2C 478 aa%3B fasta scores: opt: 1022 z-score: 1213.9 E(): 0%3B 61.5%25 identity in 247 aa overlap. Contains possible hydrophobic membrane spanning regions at C-terminal domain~SCK20.16%2C probable transferase (fragment)%2C len: >92 aa%3B similar to N-terminal region of SW:GTRB_BPSF5 (EMBL:U82619) Shigella flexneri bacteriophage V bactoprenol glucosyl transferase (EC 2.4.1.-) GtrB%2C 307 aa%3B fasta scores: opt: 264 z-score: 364.3 E(): 9.3e-13%3B 47.3%25 identity in 91 aa overlap and to N-terminal region of TR:O86666 (EMBL:AL031182) Streptomyces coelicolor sugar transferase SC4A2.10c%2C 478 aa%3B fasta scores: opt: 341 z-score: 431.2 E(): 2.4e-18%3B 61.1%25 identity in 90 aa overlap gene gene4927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4875 SCO4876 SCO4876 2SCK8.02 2SCK8.02 5307574 5308020 + sugar translocase 2SCK8.02%2C possible sugar translocase%2C len: 148 aa%3B similar to SW:GTRA_BPP22 (EMBL:AF217253) Bacteriophage P22 bactoprenol-linked glucose translocase GtrA%2C 120 aa%3B fasta scores: opt: 121 z-score: 160.1 E(): 0.24%3B 24.2%25 identity in 124 aa overlap and to C-terminal part of TR:O86666 (EMBL:AL031182) Streptomyces coelicolor sugar transferase SC4A2.10c%2C 478 aa%3B fasta scores: opt: 349 z-score: 420.7 E(): 7.2e-16%3B 42.4%25 identity in 125 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4876 SCO4877 SCO4877 2SCK8.03c 2SCK8.03c 5308045 5309379 - hypothetical protein 2SCK8.03c%2C unknown%2C len: 444 aa gene gene4929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4877 SCO4878 SCO4878 2SCK8.04c 2SCK8.04c 5309376 5310356 - glycosyltransferase 2SCK8.04c%2C possible glycosyltransferase%2C len: 326 aa%3B similar to TR:AAG44714 (EMBL:AF267127) Lactobacillus delbrueckii glycosyltransferase EpsJ%2C 327 aa%3B fasta scores: opt: 319 z-score: 393.4 E(): 2.5e-14%3B 30.5%25 identity in 236 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases gene gene4930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4878 SCO4879 SCO4879 2SCK8.05 2SCK8.05 5310555 5311886 + hypothetical protein 2SCK8.05%2C hypothetical protein%2C len: 443 aa%3B central region presents low similarity with TR:Q9K1M6 (EMBL:AE002366) Neisseria meningitidis hypothetical protein NMB0065%2C 308 aa%3B fasta scores: opt: 341 z-score: 354.4 E(): 3.6e-12%3B 26.6%25 identity in 334 aa overlap gene gene4931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4879 SCO4880 SCO4880 2SCK8.06 2SCK8.06 5312075 5313349 + transferase 2SCK8.06%2C possible transferase%2C len: 424 aa%3B similar to TR:O88719 (EMBL:AJ006215) Mus musculus CMP-N-acetylneuraminic acid synthetase (EC 2.7.7.43) CmaS%2C 432 aa%3B fasta scores: opt: 361 z-score: 400.1 E(): 1e-14%3B 30.3%25 identity in 389 aa overlap. Contains Pfam matches to entries PF02348 Cytidylyl_trans%2C Cytidylyl transferase and PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase gene gene4932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4880 SCO4881 SCO4881 2SCK8.07 2SCK8.07 5313363 5314301 + polysaccharide biosynthesis-like protein 2SCK8.07%2C possible polysaccharide biosynthesis related protein%2C len: 312 aa%3B similar to SW:SPSE_BACSU (EMBL:X73124) Bacillus subtilis spore coat polysaccharide biosynthesis protein SpsE%2C 373 aa%3B fasta scores: opt: 473 z-score: 554.3 E(): 2.6e-23%3B 32.2%25 identity in 295 aa overlap and to TR:Q9NR45 (EMBL:AF257466) Homo sapiens N-acetylneuraminic acid phosphate synthase%2C 359 aa%3B fasta scores: opt: 660 z-score: 771.2 E(): 0%3B 38.4%25 identity in 294 aa overlap. Contains matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00639 Eukaryotic thiol (cysteine) proteases histidine active site gene gene4933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4881 SCO4882 SCO4882 2SCK8.08 2SCK8.08 5314345 5315412 + hypothetical protein 2SCK8.08%2C unknown%2C len: 355 aa gene gene4934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4882 SCO4883 SCO4883 2SCK8.09 2SCK8.09 5315652 5316884 + peptidase 2SCK8.09%2C probable peptidase%2C len: 410 aa%3B similar to SW:CBPX_SULSO (EMBL:Z48497) Sulfolobus solfataricus thermostable carboxypeptidase (EC 3.4.17.*) CpsA%2C 393 aa%3B fasta scores: opt: 687 z-score: 803.2 E(): 0%3B 32.0%25 identity in 372 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20%2C Peptidase family M20/M25/M40 gene gene4935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4883 SCO4884 SCO4884 2SCK8.10 2SCK8.10 5317104 5318147 + lipoprotein 2SCK8.10%2C probable lipoprotein%2C len: 347 aa%3B similar to SW:YUFN_BACSU (EMBL:Z93937) Bacillus subtilis hypothetical lipoprotein precursor YufN%2C 350 aa%3B fasta scores: opt: 690 z-score: 727.5 E(): 0%3B 37.4%25 identity in 348 aa overlap%2C to TR:CAC14304 (EMBL:AJ276209) Clostridium sticklandii substrate binding lipoprotein precursor of an ABC transporter BmpA%2C 349 aa%3B fasta scores: opt: 557 z-score: 589.0 E(): 3.1e-25%3B 36.6%25 identity in 352 aa overlap and to Streptomyces coelicolor probable lipoprotein 2SCK8.11%2C 348 aa%3B fasta scores: opt: 1727 z-score: 1625.1 E(): 0%3B 78.4%25 identity in 347 aa overlap. Contains Pfam match to entry PF02608 Bmp and properly positioned match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene4936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4884 SCO4885 SCO4885 2SCK8.11 2SCK8.11 5318421 5319467 + lipoprotein 2SCK8.11%2C probable lipoprotein%2C len: 348 aa%3B similar to SW:YUFN_BACSU (EMBL:Z93937) Bacillus subtilis hypothetical lipoprotein precursor YufN%2C 350 aa%3B fasta scores: opt: 663 z-score: 689.2 E(): 8e-31%3B 36.8%25 identity in 334 aa overlap%2C to TR:CAC14304 (EMBL:AJ276209) Clostridium sticklandii substrate binding lipoprotein precursor of an ABC transporter BmpA%2C 349 aa%3B fasta scores: opt: 560 z-score: 583.6 E(): 6e-25%3B 36.1%25 identity in 355 aa overlap and to Streptomyces coelicolor probable lipoprotein 2SCK8.10%2C 347 aa%3B fasta scores: opt: 1727 z-score: 1622.6 E(): 0%3B 78.4%25 identity in 347 aa overlap. Contains Pfam match to entry PF02608 Bmp and properly positioned match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene4937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4885 SCO4886 SCO4886 2SCK8.12 2SCK8.12 5319704 5321317 + sugar ABC transporter ATP-binding protein 2SCK8.12%2C probable sugar ABC transporter ATP-binding protein%2C len: 537 aa%3B similar to SW:MGLA_ECOLI (EMBL:M59444) Escherichia coli galactoside transport ATP-binding protein MglA%2C 506 aa%3B fasta scores: opt: 1019 z-score: 1013.7 E(): 0%3B 35.6%25 identity in 486 aa overlap. Contains 2x Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4886 SCO4887 SCO4887 2SCK8.13 2SCK8.13 5321317 5322441 + sugar ABC transporter integral membrane protein 2SCK8.13%2C probable sugar ABC transporter integral membrane protein%2C len: 374 aa%3B similar to TR:CAC14306 (EMBL:AJ276209) Clostridium sticklandii permease 1 of an ABC transporter RbsC-1%2C 354 aa%3B fasta scores: opt: 623 z-score: 693.9 E(): 4.4e-31%3B 33.3%25 identity in 342 aa overlap. Contains Pfam match to entry PF02653 BPD_transp_2 and possible hydrophobic membrane spanning regions gene gene4939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4887 SCO4888 SCO4888 2SCK8.14 2SCK8.14 5322438 5323712 + sugar ABC transporter integral membrane protein 2SCK8.14%2C probable sugar ABC transporter integral membrane protein%2C len: 424 aa%3B similar to TR:Q9WXW0 (EMBL:AE001696) Thermotoga maritima sugar ABC transporter%2C permease TM0105%2C 319 aa%3B fasta scores: opt: 395 z-score: 433.3 E(): 1.4e-16%3B 36.9%25 identity in 279 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4888 SCO4889 SCO4889 2SCK8.15 2SCK8.15 5323709 5324101 + cytidine deaminase Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis gene gene4941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4889 SCO4890 SCO4890 deoA deoA 5324126 5325409 + thymidine phosphorylase Catalyzes the reversible phosphorolysis of thymidine%2C deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate gene gene4942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4890 SCO4891 SCO4891 2SCK8.17c 2SCK8.17c 5325467 5325853 - hypothetical protein 2SCK8.17c%2C hypothetical protein%2C len: 128 aa. Contains possible N-terminal region signal peptide sequence gene gene4943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4891 SCO4892 SCO4892 2SCK8.18 2SCK8.18 5326034 5327032 + regulatory protein 2SCK8.18%2C possible regulatory protein%2C len: 340 aa%3B similar to TR:Q9XBC8 (EMBL:AL078635) Amycolatopsis orientalis transcriptional regulator CZA382.23c%2C 335 aa%3B fasta scores: opt: 222 z-score: 228.5 E(): 3.6e-05%3B 33.0%25 identity in 345 aa overlap gene gene4944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4892 SCO4893 SCO4893 2SCK8.19c 2SCK8.19c 5327081 5328004 - transport integral membrane protein 2SCK8.19c%2C possible transport integral membrane protein%2C len: 307 aa%3B similar to SW:MDCF_RHIME (EMBL:AF155772) Rhizobium meliloti malonate transporter MdcF%2C 320 aa%3B fasta scores: opt: 306 z-score: 339.0 E(): 2.6e-11%3B 27.4%25 identity in 299 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4893 SCO4894 SCO4894 2SCK8.20c 2SCK8.20c 5328163 5328414 - hypothetical protein 2SCK8.20c%2C unknown%2C len: 83 aa gene gene4946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4894 SCO4895 SCO4895 2SCK8.21c 2SCK8.21c 5328418 5329422 - RNA polymerase factor sigma-70 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates gene gene4947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4895 SCO4896 SCO4896 2SCK8.22c 2SCK8.22c 5329530 5330840 - transport integral membrane protein 2SCK8.22c%2C probable transport integral membrane protein%2C len: 436 aa%3B similar to TR:AAG56583 (EMBL:AE005383) Escherichia coli O157:H7 transport protein YnfM%2C 417 aa%3B fasta scores: opt: 971 z-score: 995.9 E(): 0%3B 38.8%25 identity in 418 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and matches to Prosite entries PS00216 Sugar transport proteins signature 1 and PS00017 ATP/GTP-binding site motif A (P-loop. Also contains possible hydrophobic membrane spanning regions) gene gene4948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4896 SCO4897 SCO4897 2SCK8.23 2SCK8.23 5330904 5331857 + transcriptional regulator 2SCK8.23%2C probable transcriptional regulator%2C len: 317 aa%3B similar to TR:Q9KIF0 (EMBL:AF235504) Streptomyces hygroscopicus var. ascomyceticus transcription regulator FkbR1%2C 297 aa%3B fasta scores: opt: 726 z-score: 799.4 E(): 0%3B 45.8%25 identity in 286 aa overlap. Contains possible helix-turn-helix motif at residues 38..59 (+4.22 SD) gene gene4949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4897 SCO4898 SCO4898 2SCK8.24c 2SCK8.24c 5331991 5332572 - TetR family transcriptional regulator 2SCK8.24c%2C probable tetR-family transcriptional regulator%2C len: 193 aa%3B similar to TR:Q9Z551 (EMBL:AL035212) Streptomyces coelicolor transcriptional regulator SC9B2.08c%2C 192 aa%3B fasta scores: opt: 235 z-score: 290.5 E(): 1.3e-08%3B 35.3%25 identity in 187 aa overlap and to SW:BETI_ECOLI (EMBL:X52905) Escherichia coli regulatory protein BetI%2C 195 aa%3B fasta scores: opt: 161 z-score: 202.7 E(): 0.001%3B 28.5%25 identity in 186 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 32..53 (+4.35 SD) gene gene4950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4898 SCO4899 SCO4899 2SCK8.25 2SCK8.25 5332682 5333560 + hypothetical protein 2SCK8.25%2C hypothetical protein%2C len: 292 aa%3B similar to TR:Q9X7Q1 (EMBL:AL049587) Streptomyces coelicolor hypothetical alanine-rich protein SC5F2A.28c%2C 292 aa%3B fasta scores: opt: 716 z-score: 814.7 E(): 0%3B 44.9%25 identity in 274 aa overlap gene gene4951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4899 SCO4900 SCO4900 2SCK8.26c 2SCK8.26c 5333649 5334410 - hypothetical protein 2SCK8.26c%2C hypothetical protein%2C len: 253 aa%3B similar to TR:Q9RD48 (EMBL:AL133424) Streptomyces coelicolor hypothetical 31.2 kDa protein SCF56.19%2C 297 aa%3B fasta scores: opt: 376 z-score: 449.5 E(): 1.8e-17%3B 36.4%25 identity in 253 aa overlap gene gene4952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4900 SCO4901 SCO4901 2SCK8.27 2SCK8.27 5334546 5335736 + adenosine deaminase catalyzes the formation of inosine from adenosine gene gene4953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4901 SCO4902 SCO4902 2SCK8.28 2SCK8.28 5335877 5336245 + hypothetical protein 2SCK8.28%2C possible hypothetical protein%2C len: 122 aa. Contains possible cleavable N-terminal region signal peptide sequence gene gene4954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4902 SCO4903 SCO4903 2SCK8.29c 2SCK8.29c 5336333 5336536 - hypothetical protein 2SCK8.29c%2C possible membrane protein%2C len: 67aa%3B similar to TR:O34719 (EMBL:AF017113) Bacillus subtilis YvlC protein%2C 65 aa%3B fasta scores: opt: 107 z-score: 169.7 E(): 0.069%3B 33.9%25 identity in 62 aa overlap. Contains possible hydrophobic membrane spanning region gene gene4955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4903 SCO4904 SCO4904 2SCK8.30c 2SCK8.30c 5336632 5337183 - hypothetical protein 2SCK8.30c%2C possible integral membrane protein%2C len: 183 aa%3B similar to TR:CAC14351 (EMBL:AL445945) Streptomyces coelicolor integral membrane protein 2SCF60.18%2C 179 aa%3B fasta scores: opt: 193 z-score: 230.8 E(): 2.7e-05%3B 32.0%25 identity in 153 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene4956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4904 SCO4905 SCO4905 2SCK8.31c 2SCK8.31c 5337310 5337921 - lipoprotein 2SCK8.31c%2C possible lipoprotein%2C len: 203 aa%3B similar to TR:Q9K453 (EMBL:AL359215) Streptomyces coelicolor hypothetical protein SC2H12.31%2C 211 aa%3B fasta scores: opt: 142 z-score: 175.4 E(): 0.033%3B 29.3%25 identity in 205 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene4957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4905 SCO4906 SCO4906 2SCK8.32c 2SCK8.32c 5337921 5339528 - sensor kinase 2SCK8.32c%2C afsQ2%2C sensor kinase%2C len: 535 aa%3B identical to previously sequenced SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2%2C 535 aa. Contains 3x Pfam matches to entries PF00672 DUF5%2C HAMP domain%2C PF00512 signal%2C Histidine kinase and PF02518 HATPase_c%2C Histidine kinase. Contains possible hydrophobic membrane spanning region gene gene4958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4906 SCO4907 SCO4907 2SCK8.33c 2SCK8.33c 5339525 5340202 - transcriptional regulator 2SCK8.33c%2C afsQ1%2C transcriptional regulatory protein%2C len: 225 aa%3B identical to previously sequenced SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1%2C 225 aa and highly similar to TR:Q9K455 (EMBL:AL359215) Streptomyces coelicolor two-component system response regulator SC2H12.29%2C 229 aa%3B fasta scores: opt: 920 z-score: 981.8 E(): 0%3B 61.0%25 identity in 228 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene4959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4907 SCO4908 SCO4908 2SCK8.34 2SCK8.34 5340552 5341142 + RNA polymerase sigma factor 2SCK8.34%2C probable RNA polymerase sigma factor (fragment)%2C len: 196 aa%3B similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma factor SigE%2C 176 aa%3B fasta scores: opt: 377 z-score: 396.4 E(): 1.7e-14%3B 44.6%25 identity in 148 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 148..169 (+3.34 SD) gene gene4960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4908 SCO4909 SCO4909 SCK13.01c SCK13.01c 5341385 5342161 - ATP-binding protein SCK13.01c%2C possible ATP-binding protein%2C len: 258 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4909 SCO4910 SCO4910 SCK13.02 SCK13.02 5342180 5342584 + hypothetical protein SCK13.02%2C unknown%2C len: 134 aa gene gene4962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4910 SCO4911 SCO4911 SCK13.03 SCK13.03 5342742 5344754 + hypothetical protein SCK13.03%2C possible bifunctional protein%2C len: 670 aa%3B N-terminal domain similar to N-terminal domain of TR:Q9S2A6 (EMBL:AL096849) Streptomyces coelicolor Ser/Thr protein kinase SCI11.13%2C 550 aa%3B fasta scores: opt: 895 z-score: 689.8 E(): 6.8e-31%3B 44.2%25 identity in 398 aa overlap and C-terminal domain similar to SW:GLNH_BACST (EMBL:M61017) Bacillus stearothermophilus glutamate-binding protein precursor GlnH%2C 262 aa%3B fasta score: opt: 50 z-score:0.0 E(): 0%3B 52.88%25 identity in 295 nt overlap. Contains Pfam matches to entries PF00069 pkinase%2C Eukaryotic protein kinase domain and PF00497 SBP_bac_3%2C Bacterial extracellular solute-binding proteins%2C family 3 and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature%2C PS00108 Ser/Thr protein kinases active-site signature and PS01039 Bacterial extracellular solute-binding proteins%2C family 3 signature gene gene4963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4911 SCO4912 SCO4912 SCK13.04c SCK13.04c 5344860 5345741 - aldehyde dehydrogenase SCK13.04c%2C possible aldehyde dehydrogenase%2C len: 293 aa%3B similar to C-terminal region of many eukaryotic aldehyde dehydrogenases%2C e.g. TR:Q9LLR2 (EMBL:AF162665) Oryza sativa aldehyde dehydrogenase AldH%2C 549 aa%3B fasta scores: opt: 445 z-score: 486.0 E(): 1.6e-19%3B 36.3%25 identity in 248 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family gene gene4964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4912 SCO4913 SCO4913 SCK13.05c SCK13.05c 5345752 5347194 - aldehyde dehydrogenase SCK13.05c%2C probable aldehyde dehydrogenase%2C len: aa%3B similar to SW:DHA5_YEAST (EMBL:X85987) Saccharomyces cerevisiae aldehyde dehydrogenase 2 (EC 1.2.1.5) Ald5%2C 506 aa%3B fasta scores: opt: 1336 z-score: 1519.8 E(): 0%3B 46.1%25 identity in 462 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family and match to Prosite entry PS00070 Aldehyde dehydrogenases cysteine active site gene gene4965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4913 SCO4914 SCO4914 SCK13.06c SCK13.06c 5347200 5348195 - 2-deoxyribose-5-phosphate aldolase SCK13.06c%2C probable deoxyribose-phosphate aldolase%2C len: 331 aa%3B similar to SW:DEOC_ECOLI (EMBL:X03224) Escherichia coli deoxyribose-phosphate aldolase (EC 4.1.2.4) DeoC%2C 259 aa%3B fasta scores: opt: 663 z-score: 743.7 E(): 0%3B 47.3%25 identity in 256 aa overlap. Contains Pfam match to entry PF01791 DeoC%2C Deoxyribose-phosphate aldolase gene gene4966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4914 SCO4915 SCO4915 SCK13.07 SCK13.07 5348311 5349015 + hypothetical protein SCK13.07%2C possible integral membrane protein%2C len: 234 aa. Contains 3 possible hydrophobic membrane spanning regions gene gene4967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4915 SCO4916 SCO4916 SCK13.08c SCK13.08c 5349119 5350768 - phosphomannomutase SCK13.08c%2C possible phosphomannomutase%2C len: 549 aa%3B similar to TR:O53360 (EMBL:AL021841) Mycobacterium tuberculosis phosphomannomutase MTV016.07%2C 534 aa%3B fasta scores: opt: 1378 z-score: 1522.6 E(): 0%3B 46.7%25 identity in 529 aa overlap. Contains Pfam match to entry PF00408 PGM_PMM%2C Phosphoglucomutase/phosphomannomutase and match to Prosite entry PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature gene gene4968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4916 SCO4917 SCO4917 SCK13.09c SCK13.09c 5351124 5351948 - purine nucleoside phosphorylase catalyzes the formation of a purine and ribose phosphate from a purine nucleoside%3B in E. coli this enzyme functions in xanthosine degradation gene gene4969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4917 SCO4918 SCO4918 SCK13.10c SCK13.10c 5352042 5352479 - hypothetical protein SCK13.10c%2C conserved hypothetical protein%2C len: 145 aa%3B similar to TR:O53356 (EMBL:AL021841) Mycobacterium tuberculosis hypothetical 17.5 kDa protein MTV016.03%2C 159 aa%3B fasta scores: opt: 621 z-score: 794.6 E(): 0%3B 60.4%25 identity in 149 aa overlap gene gene4970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4918 SCO4919 SCO4919 SCK13.11 SCK13.11 5352587 5354014 + flavoprotein disulfide reductase catalyzes the reduction of nonspecific electron acceptors such as 2%2C6-dimethyl-1%2C4-benzoquinone and 5-hydroxy-1%2C4-naphthaquinone%3B does not have lipoamide dehydrogenase activity gene gene4971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4919 SCO4920 SCO4920 SCK13.12 SCK13.12 5354229 5355182 + DeoR family transcriptional regulator SCK13.12%2C probable deoR-family transcriptional regulator%2C len: 317 aa%3B similar to SW:GATR_ECOLI (EMBL:AE000298) Escherichia coli galactitol utilization operon repressor GatR%2C 259 aa%3B fasta scores: opt: 442 z-score: 423.7 E(): 4.6e-16%3B 34.6%25 identity in 237 aa overlap. Contains Pfam match to entry PF00455 deoR%2C Bacterial regulatory proteins%2C deoR family and match to Prosite entry PS00894 Bacterial regulatory proteins%2C deoR family signature. Also contains possible helix-turn-helix motif at residues 8..29 (+4.06 SD) gene gene4972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4920 SCO4921 SCO4921 accA2 accA2 5355283 5357055 - acyl-CoA carboxylase complex A subunit SCK13.13c%2C accA2%2C acyl-CoA carboxylase complex A subunit%2C len: 590 aa%3B identical to previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor acyl-CoA carboxylase complex A subunit AccA2%2C 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain%2C Carbamoyl-phosphate synthase (CPSase) and PF00364 biotin_lipoyl%2C Biotin-requiring enzymes and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site gene gene4973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4921 SCO4922 SCO4922 SCK13.14 SCK13.14 5357430 5357912 + hypothetical protein SCK13.14%2C possible integral membrane protein%2C len: 160 aa. Contains 4 possible hydrophobic membrane spanning regions gene gene4974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4922 SCO4923 SCO4923 SCK13.15c SCK13.15c 5357881 5358501 - hypothetical protein SCK13.15c%2C conserved hypothetical protein%2C len: 206 aa%3B similar to TR:P74331 (EMBL:D90914) Synechocystis sp. hypothetical protein Maf%2C 195 aa%3B fasta scores: opt: 565 z-score: 677.1 E(): 3.5e-30%3B 49.2%25 identity in 193 aa overlap gene gene4975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4923 SCO4924 SCO4924 SCK13.16c SCK13.16c 5358534 5358662 - hypothetical protein SCK13.16c%2C possible membrane protein%2C len: 42 aa. Contains possible hydrophobic membrane spanning region gene gene4976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4924 SCO4925 SCO4925 SCK13.17c SCK13.17c 5358799 5359008 - hypothetical protein SCK13.17c%2C unknown%2C len: 69 aa gene gene4977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4925 SCO4926 SCO4926 pccB pccB 5359018 5360610 - propionyl-CoA carboxylase complex B subunit SCK13.18c%2C pccB%2C propionyl-CoA carboxylase complex B subunit%2C len: 530 aa%3B identical to previously sequenced TR:Q9X4K7 (EMBL:AF113605) Streptomyces coelicolor propionyl-CoA carboxylase complex B subunit PccB%2C 530 aa and similar to TR:O86517 (EMBL:AL031124) Streptomyces coelicolor carboxyl transferase SC1C2.16%2C 527 aa%3B fasta scores: opt: 1958 z-score: 2071.4 E(): 0%3B 57.4%25 identity in 526 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans%2C Carboxyl transferase domain gene gene4978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4926 SCO4927 SCO4927 SCK13.19 SCK13.19 5360721 5361596 + ligase SCK13.19%2C probable ligase%2C len: 291 aa%3B similar to C-terminal domain of SW:BIRA_ECOLI (EMBL:M10123) Escherichia coli BirA bifunctional protein [includes: biotin operon repressor biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.1) (biotin--protein ligase)]%2C 321 aa%3B fasta scores: opt: 340 z-score: 382.0 E(): 9.7e-14%3B 32.7%25 identity in 260 aa overlap. Contains Pfam match to entry PF01317 BPL%2C Biotin protein ligase catalytic domain and PF02237 BPL_C%2C Biotin protein ligase C terminal domain gene gene4979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4927 SCO4928 SCO4928 cya cya 5361712 5362857 + adenylate cyclase SCK13.20%2C cya%2C adenylate cyclase%2C len: 381 aa%3B identical to previously sequenced SW:CYAA_STRCO (EMBL:X74768) Streptomyces coelicolor adenylate cyclase (EC 4.6.1.1) Cya%2C 381 aa. Contains Pfam match to entry PF00211 guanylate_cyc%2C Adenylate and Guanylate cyclase catalytic domain gene gene4980 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4928 SCO4929 SCO4929 SCK13.21c SCK13.21c 5362921 5363586 - hypothetical protein SCK13.21c%2C possible membrane protein%2C len: 221 aa. High content in proline amino acid residues and in G+C (81.74%25). Contains possible hydrophobic membrane spanning region gene gene4981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4929 SCO4930 SCO4930 SCK13.22 SCK13.22 5363797 5364597 + enoyl-CoA hydratase SCK13.22%2C probable enoyl-CoA hydratase%2C len: 266 aa%3B similar to SW:PAAF_ECOLI (EMBL:AE000236) Escherichia coli probable enoyl-CoA hydratase PaaF (EC 4.2.1.17)%2C 255 aa%3B fasta scores: opt: 562 z-score: 664.6 E(): 1.8e-29%3B 40.2%25 identity in 259 aa overlap. Contains Pfam match to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family and match to Prosite entry PS00166 Enoyl-CoA hydratase/isomerase signature gene gene4982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4930 SCO4931 SCO4931 SCK13.23 SCK13.23 5364745 5365845 + hypothetical protein SCK13.23%2C possible membrane protein%2C len: 366 aa%3B highly similar to C-terminal region of SW:YHUH_STRGR (EMBL:M77841) Streptomyces griseus hypothetical protein in HutH 5' region (fragment)%2C 241 aa%3B fasta scores: opt: 1253 z-score: 1461.2 E(): 0%3B 81.0%25 identity in 242 aa overlap. Contains Pfam match to entry PF00990 DUF9%2C Domain of unknown function DUF9. Contains possible hydrophobic membrane spanning region gene gene4983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4931 SCO4932 SCO4932 hutH hutH 5365963 5367501 + histidine ammonia-lyase catalyzes the degradation of histidine to urocanate and ammmonia gene gene4984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4932 SCO4933 SCO4933 SCK13.25 SCK13.25 5367731 5368444 + hypothetical protein SCK13.25%2C unknown%2C len: 237 aa gene gene4985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4933 SCO4934 SCO4934 SCK13.26 SCK13.26 5368677 5369921 + lipoprotein SCK13.26%2C possible lipoprotein%2C len: 414 aa%3B similar to TR:Q9KYV1 (EMBL:AL355832) Streptomyces coelicolor lipoprotein SCE22.11%2C 407 aa%3B fasta scores: opt: 1603 z-score: 1740.6 E(): 0%3B 60.5%25 identity in 415 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene4986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4934 SCO4935 SCO4935 SCK13.27 SCK13.27 5370069 5371559 + hypothetical protein SCK13.27%2C possible integral membrane protein%2C len: 496 aa%3B C-terminal region similar to C-terminal region of similar to TR:Q9UX75 (EMBL:Y18930) Sulfolobus solfataricus hypothetical 43.0 kDa protein ORF-C10_044%2C 418 aa%3B fasta scores: opt: 332 z-score: 303.7 E(): 2.2e-09%3B 27.1%25 identity in 325 aa overlap. Contains 4 possible hydrophobic membrane spanning regions gene gene4987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4935 SCO4936 SCO4936 SCK13.28 SCK13.28 5371593 5372276 + ABC transporter ATP-binding protein SCK13.28%2C possible ABC transporter ATP-binding protein%2C len: 227 aa%3B similar to TR:Q9KRR8 (EMBL:AE004234) Vibrio cholerae ABC transporter%2C ATP-binding protein VC1568%2C 233 aa%3B fasta scores: opt: 746 z-score: 833.1 E(): 0%3B 51.1%25 identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene4988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4936 SCO4937 SCO4937 SCK13.29c SCK13.29c 5372301 5372819 - hypothetical protein SCK13.29c%2C hypothetical protein%2C len: 172 aa%3B similar to TR:CAC04235 (EMBL:AL391515) Streptomyces coelicolor conserved hypothetical protein SC4B10.30c%2C 156 aa%3B fasta scores: opt: 215 z-score: 274.7 E(): 9.2e-08%3B 30.9%25 identity in 139 aa overlap gene gene4989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4937 SCO4938 SCO4938 SCK13.30 SCK13.30 5373018 5373932 + ECF-sigma factor SCK13.30%2C possible ECF-sigma factor%2C len: 304 aa%3B similar to TR:Q9RJS2 (EMBL:AL132707) Streptomyces coelicolor RNA polymerase sigma factor SCF51.13c%2C 298 aa%3B fasta scores: opt: 1110 z-score: 1299.2 E(): 0%3B 58.4%25 identity in 296 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 144..165 (+2.59 SD) gene gene4990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4938 SCO4939 SCO4939 SCK13.31c SCK13.31c 5373976 5374758 - hypothetical protein SCK13.31c%2C unknown%2C len: 260 aa gene gene4991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4939 SCO4940 SCO4940 SCK13.32 SCK13.32 5374860 5375462 + TetR family transcriptional regulator SCK13.32%2C possible tetR-family transcriptional regulator%2C len: 200 aa%3B similar to TR:Q9KZX2 (EMBL:AL353815) Streptomyces coelicolor transcriptional regulator SCD6.32c%2C 200 aa%3B fasta scores: opt: 183 z-score: 230.1 E(): 2.8e-05%3B 28.3%25 identity in 159 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 33..54 (+4.53 SD) gene gene4992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4940 SCO4941 SCO4941 2SCK31.01c 2SCK31.01c 5375466 5375783 - hypothetical protein 2SCK31.01c%2C hypothetical protein%2C len: 105 aa%3B similar to TR:Q9KZT7 (EMBL:AL353832) Streptomyces coelicolor hypothetical 20.2 kDa protein (fragment) SCE6.01c%2C 183 aa%3B fasta scores: opt: 191 z-score: 223.2 E(): 6.8e-05%3B 41.5%25 identity in 82 aa overlap gene gene4993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4941 SCO4942 SCO4942 2SCK31.02c 2SCK31.02c 5375964 5376644 - regulatory protein 2SCK31.02c%2C possible regulatory protein%2C len: 226 aa%3B similar to TR:Q9KXX1 (EMBL:AL357432) Streptomyces coelicolor transcriptional regulator SCD95A.03c%2C 199 aa%3B fasta scores: opt: 414 z-score: 464.7 E(): 2.4e-18%3B 38.2%25 identity in 204 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene4994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4942 SCO4943 SCO4943 2SCK31.03 2SCK31.03 5376765 5377757 + oxidoreductase 2SCK31.03%2C probable oxidoreductase%2C len: 330 aa%3B similar to TR:AAG05923 (EMBL:AE004681) Pseudomonas aeruginosa probable oxidoreductase PA2535%2C 331 aa%3B fasta scores: opt: 1001 z-score: 1136.6 E(): 0%3B 48.2%25 identity in 328 aa overlap. Contains Pfam match to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene4995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4943 SCO4944 SCO4944 2SCK31.04c 2SCK31.04c 5377855 5378730 - DNA-binding protein 2SCK31.04c%2C possible DNA-binding protein%2C len: 314 aa%3B similar to TR:Q9RI67 (EMBL:AL109949) Streptomyces coelicolor DNA-binding protein SCJ11.39c%2C 279 aa%3B fasta scores: opt: 544 z-score: 640.7 E(): 3.8e-28%3B 40.2%25 identity in 249 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and possible helix-turn-helix motif at residues 64..85 (+4.67 SD) gene gene4996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4944 SCO4945 SCO4945 2SCK31.05 2SCK31.05 5378899 5379939 + dehydrogenase 2SCK31.05%2C probable dehydrogenase%2C len: 346 aa%3B highly similar to SW:ADH_MYCTU (EMBL:AL021287) Mycobacterium bovis NADP-dependent alcohol dehydrogenase AdhC%2C 346 aa%3B fasta scores: opt: 1508 z-score: 1698.9 E(): 0%3B 64.5%25 identity in 346 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and matches to Prosite entries PS00059 Zinc-containing alcohol dehydrogenases signature and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene4997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4945 SCO4946 SCO4946 2SCK31.06 2SCK31.06 5380116 5380907 + hypothetical protein 2SCK31.06%2C hypothetical protein%2C len: 263 aa%3B highly similar to TR:Q9L114 (EMBL:AL159139) Streptomyces coelicolor hypothetical 27.0 kDa protein SCL6.02%2C 255 aa%3B fasta scores: opt: 711 z-score: 830.9 E(): 0%3B 49.4%25 identity in 253 aa overlap gene gene4998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4946 SCO4947 SCO4947 2SCK31.07 2SCK31.07 5381148 5384831 + nitrate reductase subunit alpha NarG3 2SCK31.07%2C narG3%2C nitrate reductase alpha chain%2C len: 1227 aa%3B highly similar to SW:NARG_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase alpha chain (EC 1.7.99.4)NarG%2C 1228 aa%3B fasta scores: opt: 4080 z-score: 4618.0 E(): 0%3B 49.5%25 identity in 1206 aa overlap and to TR:O86717 (EMBL:AL031515) Streptomyces coelicolor NarG%2C nitrate reductase alpha chain SC5C7.20%2C 1231 aa%3B fasta scores: opt: 5648 z-score: 5294.1 E(): 0%3B 66.6%25 identity in 1232 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding%2C Molydopterin dinucleotide binding domain and matches to Prosite entries PS00551 Prokaryotic molybdopterin oxidoreductases signature 1 and PS00490 Prokaryotic molybdopterin oxidoreductases signature 2 gene gene4999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4947 SCO4948 SCO4948 2SCK31.08 2SCK31.08 5384840 5386486 + nitrate reductase subunit beta NarH3 2SCK31.08%2C narH3%2C nitrate reductase beta chain%2C len: 548 aa%3B highly similar to SW:NARH_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase beta chain NarH%2C 487 aa%3B fasta scores: opt: 2088 z-score: 2047.9 E(): 0%3B 58.2%25 identity in 483 aa overlap and to TR:O86716 (EMBL:AL031515) Streptomyces coelicolor NarH%2C nitrate reductase beta chain SC5C7.19%2C 531 aa%3B fasta scores: opt: 2542 z-score: 2343.2 E(): 0%3B 71.6%25 identity in 503 aa overlap gene gene5000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4948 SCO4949 SCO4949 2SCK31.09 2SCK31.09 5386483 5387145 + nitrate reductase subunit delta NarJ3 2SCK31.09%2C narJ3%2C nitrate reductase delta chain%2C len: 237 aa%3B similar to SW:NARJ_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase delta chain (EC 1.7.99.4) NarJ%2C 184 aa%3B fasta scores: opt: 332 z-score: 411.9 E(): 2.1e-15%3B 35.0%25 identity in 163 aa overlap and to TR:Q9RI30 (EMBL:AL109989) Streptomyces coelicolor NarJ2 SCJ12.30 %2C 267 aa%3B fasta scores: opt: 436 z-score: 447.2 E(): 3.3e-19%3B 41.7%25 identity in 204 aa overlap gene gene5001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4949 SCO4950 SCO4950 2SCK31.10 2SCK31.10 5387142 5387855 + nitrate reductase subunit gamma NarI3 2SCK31.10%2C narI3%2C nitrate reductase gamma chain%2C len: 237 aa%3B highly similar to SW:NARI_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase gamma chain (EC 1.7.99.4) NarI%2C 223 aa%3B fasta scores: opt: 792 z-score: 991.9 E(): 0%3B 49.6%25 identity in 234 aa overlap and to TR:Q9RI29 (EMBL:109989) Streptomyces coelicolor nitrate reductase delta chain NarI2 SCJ12.31%2C 256 aa%3B fasta scores: opt: 813 z-score: 891.7 E(): 0%3B 54.3%25 identity in 230 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4950 SCO4951 SCO4951 2SCK31.11c 2SCK31.11c 5387898 5388935 - aldoketoreductase 2SCK31.11c%2C probable aldoketoreductase%2C len: 345 aa%3B similar to TR:Q9XC70 (EMBL:AF147704) Streptomyces fradiae NDP-hexose 2%2C3-enoyl reductase TylCII%2C 329 aa%3B fasta scores: opt: 726 z-score: 830.3 E(): 0%3B 41.3%25 identity in 320 aa overlap. Contains 2x Pfam matches to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene5003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4951 SCO4952 SCO4952 2SCK31.12 2SCK31.12 5389080 5389676 + TetR family transcriptional regulator 2SCK31.12%2C probable tetR-family transcriptional regulator%2C len: 198 aa%3B similar to TR:Q9RJL5 (EMBL:AL121849) Streptomyces coelicolor tetR-family transcriptional regulator SCF6.16%2C 194 aa%3B fasta scores: opt: 355 z-score: 451.5 E(): 1.3e-17%3B 35.1%25 identity in 185 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 42..63 (+4.18 SD) gene gene5004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4952 SCO4953 SCO4953 2SCK31.13 2SCK31.13 5389724 5389918 + hypothetical protein 2SCK31.13%2C unknown%2C len: 64 aa gene gene5005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4953 SCO4954 SCO4954 2SCK31.14c 2SCK31.14c 5389941 5390534 - hypothetical protein 2SCK31.14c%2C unknown%2C len: 197 aa gene gene5006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4954 SCO4955 SCO4955 2SCK31.15c 2SCK31.15c 5390665 5391852 - ATP/GTP-binding protein 2SCK31.15c%2C hypothetical protein%2C len: 395 aa%3B similar to TR:Q9X8V7 (EMBL:AL078610) Streptomyces coelicolor hypothetical 43.9 kDa protein SCH35.49c%2C 410 aa%3B fasta scores: opt: 1788 z-score: 1973.1 E(): 0%3B 63.8%25 identity in 398 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4955 SCO4956 SCO4956 2SCK31.16 2SCK31.16 5392010 5392528 + methionine sulfoxide reductase A this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form%3B provides protection against oxidative stress gene gene5008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4956 SCO4957 SCO4957 2SCK31.17c 2SCK31.17c 5392632 5393750 - hypothetical protein 2SCK31.17c%2C membrane protein%2C len: 372 aa%3B similar to TR:Q9S2T3 (EMBL:AL096884) Streptomyces coelicolor hypothetical 40.5 kDa protein SC4G6.25%2C 376 aa%3B fasta scores: opt: 334 z-score: 393.9 E(): 2.1e-14 34.3%25 identity in 324 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5009 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4957 SCO4958 SCO4958 2SCK31.18 2SCK31.18 5393841 5395001 + cystathionine gamma-synthase catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine gene gene5010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4958 SCO4959 SCO4959 2SCK31.19c 2SCK31.19c 5395012 5395269 - hypothetical protein 2SCK31.19c%2C possible membrane protein%2C len: 85 aa. Contains possible hydrophobic membrane spanning region gene gene5011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4959 SCO4960 SCO4960 2SCK31.20c 2SCK31.20c 5395316 5395822 - sigma factor 2SCK31.20c%2C possible sigma factor%2C len: 168 aa%3B similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE%2C 176 aa%3B fasta scores: opt: 108 z-score: 140.1 E(): 2.9%3B 30.8%25 identity in 156 aa overlap gene gene5012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4960 SCO4961 SCO4961 2SCK31.21c 2SCK31.21c 5396005 5396505 - MarR family transcriptional regulator 2SCK31.21c possible marR-family transcriptional regulator%2C len: 166 aa%3B similar to SW:YXAD_BACSU (EMBL:AB005554) Bacillus subtilis hypothetical transcriptional regulator in AsnH-GntR intergenic region YxaD%2C 143 aa%3B fasta scores: opt: 268 z-score: 338.9 E(): 2.4e-11%3B 35.0%25 identity in 137 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and possible helix-turn-helix motif at residues 58..79 (+2.70 SD) gene gene5013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4961 SCO4962 SCO4962 2SCK31.22 2SCK31.22 5396674 5397903 + threonine dehydratase catalyzes the formation of 2-oxobutanoate from L-threonine gene gene5014 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4962 SCO4963 SCO4963 2SCK31.23 2SCK31.23 5398064 5399071 + ABC transporter ATP-binding protein 2SCK31.23%2C possible ABC transporter ATP-binding protein%2C len: 335 aa%3B similar to TR:CAC08315 (EMBL:AL392149) Streptomyces coelicolor ABC transport system ATP-binding protein SCD19A.14%2C 336 aa%3B fasta scores: opt: 1211 z-score: 1254.5 E(): 0%3B 58.2%25 identity in 330 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4963 SCO4964 SCO4964 2SCK31.24 2SCK31.24 5399068 5399925 + integral membrane transport protein 2SCK31.24%2C probable integral membrane transport protein%2C len: 285 aa%3B similar to TR:AAG32069 (EMBL:AF317791) Streptomyces viridochromogenes hydrophobic transmembrane protein AviABCII%2C 265 aa%3B fasta scores: opt: 677 z-score: 786.2 E(): 0%3B 39.7%25 identity in 262 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4964 SCO4965 SCO4965 greA greA 5400027 5400524 - transcription elongation factor GreA necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites%3B arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus gene gene5017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4965 SCO4966 SCO4966 2SCK31.26c 2SCK31.26c 5400705 5401103 - hypothetical protein 2SCK31.26c%2C possible membrane protein%2C len: 132 aa%3B similar to TR:O53429 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 15.4 kDa protein MTV017.34c%2C 144 aa%3B fasta scores: opt: 186 z-score: 240.5 E(): 7.4e-06%3B 27.9%25 identity in 136 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4966 SCO4967 SCO4967 2SCK31.27 2SCK31.27 5401234 5402115 + hypothetical protein 2SCK31.27%2C conserved hypothetical protein%2C len: 293 aa%3B highly similar to TR:O53430 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 32.7 kDa protein MTV017.35%2C 288 aa%3B fasta scores: opt: 992 z-score: 1173.4 E(): 0%3B 52.3%25 identity in 287 aa overlap gene gene5019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4967 SCO4968 SCO4968 2SCK31.28 2SCK31.28 5402117 5402344 + hypothetical protein 2SCK31.28%2C possible membrane protein%2C len: 75 aa. Contains possible hydrophobic membrane spanning region gene gene5020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4968 SCO4969 SCO4969 2SCK31.29c 2SCK31.29c 5402381 5405884 - regulatory protein 2SCK31.29c%2C possible regulatory protein%2C len: 1167 aa%3B similar in its middle domain to SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR%2C 993 aa%3B fasta scores: opt: 298 z-score: 279.4 E(): 5e-08%3B 28.9%25 identity in 806 aa overlap. Contains 5x Pfam matches to entry PF00515 TPR%2C TPR Domain gene gene5021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4969 SCO4970 SCO4970 2SCK31.30c 2SCK31.30c 5405887 5406039 - hypothetical protein 2SCK31.30c%2C unknown%2C len: 50 aa gene gene5022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4970 SCO4971 SCO4971 2SCK31.31 2SCK31.31 5406195 5407688 + dehydrogenase 2SCK31.31%2C possible dehydrogenase%2C len: 497 aa%3B similar to N-terminal domain of SW:XDH_MOUSE (EMBL:X75129) Mus musculus xanthine dehydrogenase/oxidase Xdh%2C 1335 aa%3B fasta scores: opt: 345 z-score: 361.7 E(): 1.3e-12 31.5%25 identity in 483 aa overlap and to TR:O54050 (EMBL:AJ001013) Rhodobacter capsulatus xanthine dehydrogenase (EC 1.1.1.204) XdhA%2C 462 aa%3B fasta scores: opt: 631 z-score: 669.1 E(): 9.8e-30%3B 38.2%25 identity in 495 aa overlap. Contains Pfam matches to entries PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains%2C PF01799 fer2_2%2C [2Fe-2S] binding domain and PF00941 dehydrog_molyb%2C Molybdopterin binding domain in dehydrogenase and match to Prosite entry PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature gene gene5023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4971 SCO4972 SCO4972 2SCK31.32 2SCK31.32 5407685 5410105 + dehydrogenase 2SCK31.32%2C possible dehydrogenase%2C len: 806 aa%3B similar to the C-terminal region of SW:XDH_MOUSE (EMBL:X75129) Mus musculus xanthine dehydrogenase/oxidase Xdh%2C 1335 aa%3B fasta scores: opt: 1456 z-score: 1610.8 E(): 0%3B 43.3%25 identity in 767 aa overlap. Contains Pfam match to entry PF01315 Ald_Xan_dh_C%2C Aldehyde oxidase and xanthine dehydrogenase%2C C terminus gene gene5024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4972 SCO4973 SCO4973 2SCK31.33 2SCK31.33 5410107 5410928 + hypothetical protein 2SCK31.33%2C conserved hypothetical protein%2C len: 273 aa%3B similar to TR:Q9RYX5 (EMBL:AE001862) Deinococcus radiodurans conserved hypothetical protein DRA0179%2C 274 aa%3B fasta scores: opt: 888 z-score: 1076.8 E(): 0%3B 52.4%25 identity in 271 aa overlap gene gene5025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4973 SCO4974 SCO4974 2SCK31.34 2SCK31.34 5411121 5411624 + deaminase 2SCK31.34%2C possible deaminase%2C len: 167 aa%3B similar to TR:AAG05887 (EMBL:AE004677) Pseudomonas aeruginosa probable deaminase PA2499%2C 151 aa%3B fasta scores: opt: 299 z-score: 372.9 E(): 3.1e-13%3B 36.6%25 identity in 123 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam%2C Cytidine and deoxycytidylate deaminase zinc-binding region gene gene5026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4974 SCO4975 SCO4975 2SCK31.35 2SCK31.35 5411702 5413762 + hypothetical protein 2SCK31.35%2C conserved hypothetical protein%2C len: 680 aa%3B similar to SW:YYAL_BACSU (EMBL:D26185) Bacillus subtilis hypothetical 78.8 kDa protein in TetB-ExoA intergenic region YyaL%2C 689 aa%3B fasta scores: opt: 1541 z-score: 1751.9 E(): 0%3B 39.2%25 identity in 683 aa overlap. Contains match to Prosite entry PS00133 Zinc carboxypeptidases%2C zinc-binding region 2 signature gene gene5027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4975 SCO4976 SCO4976 2SCK31.36c 2SCK31.36c 5413773 5414501 - hypothetical protein 2SCK31.36c%2C conserved hypothetical protein%2C len: 242 aa%3B similar to TR:O53776 (EMBL:AL021942) Mycobacterium tuberculosis hypothetical 28.5 kDa protein MTV039.17%2C 252 aa%3B fasta scores: opt: 509 z-score: 573.9 E(): 2e-24%3B 42.3%25 identity in 241 aa overlap. Contains Pfam match to entry PF01927 DUF82%2C Protein of unknown function DUF82 gene gene5028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4976 SCO4977 SCO4977 2SCK31.37c 2SCK31.37c 5414535 5415242 - TetR family transcriptional regulator 2SCK31.37c%2C probable tetR-family transcriptional regulator%2C len: 235 aa%3B similar to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR%2C 226 aa%3B fasta scores: opt: 304 z-score: 354.3 E(): 3.4e-12%3B 37.2%25 identity in 218 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 46..67 (+5.26 SD) gene gene5029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4977 SCO4978 SCO4978 2SCK36.01c 2SCK36.01c 5415297 5416001 - hypothetical protein 2SCK36.01c%2C conserved hypothetical membrane protein%2C len: 234 aa%3B similar to SW:YA85_MYCTU (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 26.0 kDa protein RV1085c or MTV017.38c%2C 242 aa%3B fasta scores: opt: 563 Z-score: 653.6 bits: 128.3 E(): 8.6e-29%3B 39.524%25 identity in 210 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4978 SCO4979 SCO4979 2SCK36.02 2SCK36.02 5416288 5418117 + phosphoenolpyruvate carboxykinase catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP gene gene5031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4979 SCO4980 SCO4980 2SCK36.03c 2SCK36.03c 5418400 5419350 - hypothetical protein 2SCK36.03c%2C unknown%2C len: 316 aa gene gene5032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4980 SCO4981 SCO4981 2SCK36.04c 2SCK36.04c 5419347 5420747 - hypothetical protein 2SCK36.04c%2C possible bifunctional protein%2C len: 466 aa%3B N-terminal region presents low similarity to N-terminal region of TR:O14362 (EMBL:Z97992) Schizosaccharomyces pombe glucan synthase-1 (EC 2.4.1.34) SPBC30D10.17c%2C 504 aa%3B fasta scores: opt: 176 Z-score: 188.3 bits: 44.3 E(): 0.0071%3B 24.931%25 identity in 361 aa overlap and C-terminal region to C-terminal region of TR:AAK22951 (EMBL:AE005774) Caulobacter crescentus oxidoreductase%2C GFO/IDH/MOCA family CC0967%2C 307 aa%3B fasta scores: opt: 146 Z-score: 160.2 bits: 38.4 E(): 0.26%3B 26.590%25 identity in 173 aa overlap gene gene5033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4981 SCO4982 SCO4982 2SCK36.05 2SCK36.05 5420938 5421120 + hypothetical protein 2SCK36.05%2C membrane protein%2C len: 60 aa. Contains possible hydrophobic membrane spanning region gene gene5034 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4982 SCO4983 SCO4983 2SCK36.06c 2SCK36.06c 5421206 5421628 - hypothetical protein 2SCK36.06c%2C unknown%2C len: 140 aa gene gene5035 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4983 SCO4984 SCO4984 2SCK36.07c 2SCK36.07c 5421700 5422911 - aminotransferase AlaT broad specificity%3B family IV%3B in Corynebacterium glutamicum this protein can use glutamate%2C 2-aminobutyrate%2C and aspartate as amino donors and pyruvate as the acceptor gene gene5036 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4984 SCO4985 SCO4985 2SCK36.08 2SCK36.08 5423145 5423999 + hypothetical protein 2SCK36.08%2C unknown%2C len: 284 aa gene gene5037 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4985 SCO4986 SCO4986 2SCK36.09c 2SCK36.09c 5424037 5425647 - D-aminoacylase 2SCK36.09c%2C probable D-aminoacylase%2C len: 536 aa%3B similar to SW:NDAD_ALCXX (EMBL:S80683) Alcaligenes xylosoxydans D-aminoacylase (EC 3.5.1.81) Dan%2C 483 aa%3B fasta scores: opt: 370 Z-score: 413.6 bits: 86.1 E(): 2e-15%3B 33.647%25 identity in 532 aa overlap gene gene5038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4986 SCO4987 SCO4987 2SCK36.10c 2SCK36.10c 5425676 5426977 - D-amino acid deaminase 2SCK36.10c%2C possible D-amino acid deaminase%2C len: 433 aa%3B similar to TR:Q45085 (EMBL:AF158699) Burkholderia cepacia D-serine deaminase Dsd%2C 432 aa%3B fasta scores: opt: 919 Z-score: 1026.2 bits: 199.0 E(): 1.5e-49%3B 41.259%25 identity in 429 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4987 SCO4988 SCO4988 2SCK36.11 2SCK36.11 5427114 5428169 + carbohydrate kinase 2SCK36.11%2C probable carbohydrate kinase%2C len: 351 aa%3B similar to TR:Q9K6K5 (EMBL:AP001519) Bacillus halodurans 2-keto-3-deoxygluconate kinase (EC 2.7.1.45) KdgK or BH3724%2C 317 aa%3B fasta scores: opt: 578 Z-score: 638.8 bits: 126.5 E(): 5.7e-28%3B 38.835%25 identity in 309 aa overlap. Contains Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase gene gene5040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4988 SCO4989 SCO4989 2SCK36.12 2SCK36.12 5428166 5428930 + IclR family transcriptional regulator 2SCK36.12%2C probable IclR-family transcriptional regulatory protein%2C len: 254 aa%3B similar to SW:KDGR_ECOLI (EMBL:AE000277) Escherichia coli transcriptional regulator KdgR%2C 263 aa%3B fasta scores: opt: 420 Z-score: 488.7 bits: 98.0 E(): 1.3e-19%3B 30.992%25 identity in 242 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator and possible helix-turn-helix motif at residues 20..41 (+3.12 SD) gene gene5041 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4989 SCO4990 SCO4990 2SCK36.13 2SCK36.13 5428927 5429337 + hypothetical protein 2SCK36.13%2C conserved hypothetical protein%2C len: 136 aa%3B similar to SW:YABJ_BACSU (EMBL:D26185) Bacillus subtilis regulator of purine biosynthesis YabJ%2C 124 aa%3B fasta scores: opt: 239 Z-score: 301.4 bits: 61.4 E(): 3.5e-09%3B 36.641%25 identity in 131 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C YjgF family gene gene5042 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4990 SCO4991 SCO4991 2SCK36.14 2SCK36.14 5429458 5430936 + sugar transport integral membrane protein 2SCK36.14%2C probable sugar transport integral membrane protein%2C len: 492 aa%3B similar to SW:GNTP_BACSU (EMBL:J02584) Bacillus subtilis gluconate permease GntP%2C 448 aa%3B fasta scores: opt: 988 Z-score: 1028.7 bits: 199.7 E(): 1.1e-49%3B 39.186%25 identity in 467 aa overlap. Contains Pfam match to entry PF02447 GntP_permease%2C GntP family permease and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible hydrophobic membrane spanning regions gene gene5043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4991 SCO4992 SCO4992 2SCK36.15 2SCK36.15 5431032 5431676 + hypothetical protein 2SCK36.15%2C unknown%2C len: 214 aa. High content of alanine and glutamic amino acid residues in C-terminal region gene gene5044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4992 SCO4993 SCO4993 2SCK36.16 2SCK36.16 5431696 5433066 + metal ion transport protein 2SCK36.16%2C possible metal ion transport protein%2C len: 456 aa%3B similar to SW:MNTH_SALTY (EMBL:AF161317) Salmonella typhimurium manganese transport protein MntH%2C 413 aa%3B fasta scores: opt: 241 Z-score: 273.7 bits: 59.8 E(): 1.2e-07%3B 20.824%25 identity in 437 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4993 SCO4994 SCO4994 2SCK36.17 2SCK36.17 5433210 5434163 + hypothetical protein 2SCK36.17%2C unknown%2C len: 317 aa gene gene5046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4994 SCO4995 SCO4995 2SCK36.18c 2SCK36.18c 5434218 5435480 - hypothetical protein 2SCK36.18c%2C membrane protein%2C len: 420 aa. Contains possible hydrophobic membrane spanning region gene gene5047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4995 SCO4996 SCO4996 2SCK36.19c 2SCK36.19c 5435560 5436069 - RNA polymerase ECF sigma factor 2SCK36.19c%2C probable RNA polymerase ECF sigma factor%2C len: 169 aa%3B similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE or SCE94.07%2C 176 aa%3B fasta scores: opt: 278 Z-score: 347.2 bits: 70.7 E(): 9.9e-12%3B 36.527%25 identity in 167 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene5048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4996 SCO4997 SCO4997 2SCK36.20c 2SCK36.20c 5436168 5436359 - hypothetical protein 2SCK36.20c%2C hypothetical protein%2C len: 63 aa%3B similar to TR:Q9F3E1 (EMBL:AL450289) Streptomyces coelicolor AbaA-like protein SC2H2.14%2C 89 aa%3B fasta scores: opt: 96 Z-score: 150.9 bits: 31.9 E(): 0.86%3B 32.787%25 identity in 61 aa overlap gene gene5049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4997 SCO4998 SCO4998 2SCK36.21c 2SCK36.21c 5436371 5437222 - hypothetical protein 2SCK36.21c%2C hypothetical protein%2C len: 283 aa%3B similar to TR:Q9XD96 (EMBL:AF106004) Streptomyces coelicolor hypothetical 31.8 kDa protein ORF3%2C 283 aa%3B fasta scores: opt: 815 Z-score: 959.3 bits: 185.4 E(): 8e-46%3B 45.230%25 identity in 283 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix gene gene5050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4998 SCO4999 SCO4999 SCK15.01 SCK15.01 5437435 5437923 + hypothetical protein SCK15.01%2C hypothetical protein%2C len: 162 aa%3B similar to TR:CAB7697 (EMBL:AL159178) Streptomyces coelicolor hypothetical 16.8 kD protein SCH22A.02c%2C 160 aa%3B fasta scores: opt: 133 z-score: 165.9 E(): 0.09%3B 28.9%25 identity in 142 aa overlap gene gene5051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO4999 SCO5000 SCO5000 SCK15.02 SCK15.02 5438306 5438614 + hypothetical protein SCK15.02%2C conserved hypothetical protein%2C len: 102 aa%3B similar to TR:CAB77311 (EMBL:AL160312) Streptomyces coelicolor hypothetical 11.3 kD protein SCD35.27c%2C 101 aa%3B fasta scores: opt: 465 z-score: 578.9 E(): 9e-25%3B 72.6%25 identity in 95 aa overlap gene gene5052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5000 SCO5001 SCO5001 SCK15.03 SCK15.03 5438611 5439252 + hypothetical protein SCK15.03%2C possible integral membrane protein%2C len: 213 aa%3B similar to TR:CAB77310 (EMBL:AL160312) Streptomyces coelicolor integral membrane protein SCD35.26%2C 198 aa%3B fasta scores: opt: 349 z-score: 424.5 E(): 3.6e-16%3B 37.4%25 identity in 182 aa overlap. Contains possible hydrophobic membrane spanning regions at C-terminal domain gene gene5053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5001 SCO5002 SCO5002 SCK15.04c SCK15.04c 5439185 5439835 - hypothetical protein SCK15.04c%2C conserved hypothetical protein%2C len: 216 aa%3B similar to TR:CAB77308 (EMBL:AL160312) Streptomyces coelicolor hypothetical 26.0 kD protein SCD35.24c%2C 241 aa%3B fasta scores: opt: 613 z-score: 732.4 E(): 0%3B 52.8%25 identity in 197 aa overlap gene gene5054 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5002 SCO5003 SCO5003 chiA chiA 5439963 5441678 - chitinase A SCK15.05c%2C chiA%2C chitinase A precursor%2C len: 571 aa%3B identical to previously sequenced TR:Q9Z9M9 (EMBL:AB017008) Streptomyces coelicolor chitinase A precursor ChiA%2C 571 aa and to TR:Q59924 (EMBL:D13775) Streptomyces lividans chitinase A precursor (EC 3.2.1.14) ChiA%2C 571 aa. Contains Pfam match to entry PF02018 CBD_6%2C Cellulose binding domain%2C PF00041 fn3%2C Fibronectin type III domain%2C PF00704 Glyco_hydro_18%2C Glycosyl hydrolases family 18 and matches to Prosite entries PS00678 Trp-Asp (WD) repeats signature and PS01095 Chitinases family 18 active site. Contains also possible N-terminal region signal peptide sequence gene gene5055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5003 SCO5004 SCO5004 SCK15.06 SCK15.06 5441997 5442938 + hypothetical protein SCK15.06%2C unknown%2C len: 313 aa. Contains hydrohilic C-terminall region gene gene5056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5004 SCO5005 SCO5005 SCK15.07 SCK15.07 5443213 5443824 + hypothetical protein SCK15.07%2C unknown%2C len: 203 aa gene gene5057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5005 SCO5006 SCO5006 minD1 minD1 5443832 5445088 + septum site-determining protein SCK15.08%2C minD1%2C possible septum site-determining protein%2C len: 418 aa%3B N-terminal domain similar to TR:Q9RZD9 (EMBL:AE001862) Deinococcus radiodurans DNA-binding response regulator DRA0010%2C 211 aa%3B blastp scores: Score %3D 103 (36.3 bits)%2C Expect %3D 0.0045%2C Identities %3D 50/194 (25%25)%2C Positives %3D 85/194 (43%25) and C-terminal domain highly similar to TR:Q9ZF15 (EMBL:AJ005576) Streptomyces griseus septum site-determining protein MinD protein%2C 396 aa%3B fasta scores: opt: 1230 z-score: 1302.8 E(): 0%3B 70.5%25 identity in 281 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00991 ParA%2C ParA family ATPase gene gene5058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5006 SCO5007 SCO5007 minD2 minD2 5445085 5445480 + septum site-determining protein SCK15.09%2C minD2%2C possible septum site-determining protein%2C len: 131 aa%3B similar to C-terminal domain of TR:Q9ZF15 (EMBL:AJ005576) Streptomyces griseus septum site-determining protein MinD protein%2C 396 aa%3B fasta scores: opt: 360 z-score: 444.6 E(): 2.7e-17%3B 47.3%25 identity in 129 aa overlap and to Streptomyces coelicolor septum site-determining protein minD3 SCK15.10%2C 131 aa%3B fasta scores: opt: 177 z-score: 196.8 E(): 2.1e-05%3B 35.8%25 identity in 109 aa overlap. Contains possible hydrophobic membrane spanning region and TTA leucine codon%2C possible target for bldA regulation gene gene5059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5007 SCO5008 SCO5008 minD3 minD3 5445482 5445877 + septum site-determining protein SCK15.10%2C minD3%2C possible septum site-determining protein%2C len: 131 aa%3B similar to TR:Q9ZF15 (EMBL:AJ005576) Streptomyces griseus septum site-determining protein MinD protein%2C 396 aa%3B fasta scores: opt: 180 z-score: 224.4 E(): 5e-05%3B 37.7%25 identity in 122 aa overlap and to Streptomyces coelicolor septum site-determining protein minD2%2C 131 aa%3B fasta scores: opt: 177 z-score: 189.4 E(): 5.4e-05%3B 36.4%25 identity in 107 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5008 SCO5009 SCO5009 SCK15.11 SCK15.11 5445896 5447233 + secretory protein SCK15.11%2C probable secretory protein%2C len: 445 aa%3B similar to TR:P94647 (EMBL:U77780) Chlorobium limicola secretory protein kinase Kbh%2C 474 aa%3B fasta scores: opt: 1192 z-score: 1311.8 E(): 0%3B 47.7%25 identity in 396 aa overlap%2C to SW:TRBB_AGRT6 (EMBL:U43675) Agrobacterium tumefaciens conjugal transfer protein TrbB%2C 323 aa%3B fasta scores: opt: 512 z-score: 568.9 E(): 3.2e-24%3B 30.4%25 identity in 326 aa overlap and to TR:Q9X921 (EMBL:AL035636) Streptomyces coelicolor secretory protein SCH5.19c%2C 523 aa%3B fasta scores: opt: 878 z-score: 847.4 E(): 0%3B 40.3%25 identity in 365 aa overlap. Contains Pfam match to entry PF00437 GSPII_E%2C Bacterial type II secretion system protein and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5009 SCO5010 SCO5010 SCK15.12 SCK15.12 5447243 5448193 + hypothetical protein SCK15.12%2C possible integral membrane protein%2C len: 316 aa%3B similar to TR:AAF40196 (EMBL:AF229646) Caulobacter crescentus hypothetical 34.6 kD protein%2C 325 aa%3B fasta scores: opt: 287 z-score: 328.2 E(): 8.2e-11%3B 21.9%25 identity in 315 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene5062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5010 SCO5011 SCO5011 SCK15.13 SCK15.13 5448213 5449115 + hypothetical protein SCK15.13%2C possible integral membrane protein%2C len: 300 aa%3B similar to TR:O27061 (EMBL:AE000871) Methanobacterium thermoautotrophicum conserved protein MTH980%2C 313 aa%3B fasta scores: opt: 235 z-score: 285.2 E(): 2e-08%3B 27.7%25 identity in 238 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene5063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5011 SCO5012 SCO5012 SCK15.14 SCK15.14 5449378 5449575 + hypothetical protein SCK15.14%2C possible integral membrane protein%2C len: 65 aa%3B similar to some other integral membrane proteins%2C e.g. TR:AAF40189 (EMBL:AF229646) Caulobacter crescentus PilA%2C 59 aa%3B fasta scores: opt: 84 z-score: 142.8 E(): 1.8%3B 36.2%25 identity in 47 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5012 SCO5013 SCO5013 SCK15.15 SCK15.15 5449578 5450174 + hypothetical protein SCK15.15%2C possible hypothetical protein%2C len: 198 aa. Contains possible N-terminal region signal peptide sequence. High content in alanine amino acid residues gene gene5065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5013 SCO5014 SCO5014 SCK15.16 SCK15.16 5450207 5450785 + hypothetical protein SCK15.16%2C possible hypothetical protein%2C len: 192 aa. Contains possible N-terminal region signal peptide sequence gene gene5066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5014 SCO5015 SCO5015 SCK15.17 SCK15.17 5450794 5451405 + hypothetical protein SCK15.17%2C possible hypothetical protein%2C len: 203 aa%3B similar to many other membrane proteins%2C e.g. TR:Q9S6B8 (EMBL:AF115336) Pseudomonas fluorescens major outer membrane protein OprF%2C 343 aa%3B fasta scores: opt: 247 z-score: 285.4 E(): 2e-08%3B 34.3%25 identity in 181 aa overlap. Contains Pfam match to entry PF00691 OmpA%2C OmpA family and possible N-terminal region signal peptide sequence gene gene5067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5015 SCO5016 SCO5016 SCK15.18c SCK15.18c 5451503 5452318 - hypothetical protein SCK15.18c%2C possible hypothetical protein%2C len: 271 aa. Contains possible N-terminal region signal peptide sequence and a repeat region: 7x AS at N-terminal domain gene gene5068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5016 SCO5017 SCO5017 SCK15.19 SCK15.19 5452526 5453623 + AraC family transcription regulator SCK15.19%2C possible araC family regulatory protein%2C len: 365 aa%3B similar to TR:Q54308 (EMBL:X86780) Streptomyces hygroscopicus helix-turn-helix DNA-binding protein%2C 330 aa%3B fasta scores: opt: 247 z-score: 294.6 E(): 6.1e-09%3B 28.6%25 identity in 346 aa overlap. Contains fam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and match to Prosite entry PS00041 Bacterial regulatory proteins%2C araC family signature. Contains also a TTA leucine codon%2C possible target for bldA regulation gene gene5069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5017 SCO5018 SCO5018 SCK15.20 SCK15.20 5453774 5453983 + hypothetical protein SCK15.20%2C possible integral membrane protein%2C len: 69 aa. Contains possible hydrophobic membrane spanning regions gene gene5070 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5018 SCO5019 SCO5019 SCK15.21c SCK15.21c 5453993 5454598 - hypothetical protein SCK15.21c%2C possible hypothetical protein%2C len: 201 aa%3B similar to TR:Q9UZM5 (EMBL:AJ248286%3B) Pyrococcus abyssi hypothetical 13.4 kD protein%2C 117 aa%3B fasta scores: opt: 167 z-score: 206.8 E(): 0.00048%3B 31.0%25 identity in 100 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene5071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5019 SCO5020 SCO5020 SCK15.22 SCK15.22 5454591 5455127 + hypothetical protein SCK15.22%2C hypothetical protein%2C len: 178 aa%3B similar to C-terminal region of TR:Q9KY81 (EMBL:AL356813) Streptomyces coelicolor lipoprotein SCK15.23%2C 221 aa%3B fasta scores: opt: 444 Z-score: 519.8 E(): 2.5e-21%3B 39.080%25 identity in 174 aa overlap gene gene5072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5020 SCO5021 SCO5021 SCK15.23 SCK15.23 5455315 5455980 + lipoprotein SCK15.23%2C possible lipoprotein%2C len: 221 aa%3B similar to Streptomyces coelicolor SCK15.24%2C 220 aa%3B fasta scores: opt: 736 z-score: 652.9 E(): 8.3e-31%3B 54.3%25 identity in 221 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene5073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5021 SCO5022 SCO5022 SCK15.24 SCK15.24 5456221 5456883 + lipoprotein SCK15.24%2C possible lipoprotein%2C len: 220 aa%3B similar to Streptomyces coelicolor SCK15.23%2C 221 aa%3B fasta scores: opt: 736 z-score: 703.5 E(): 1.3e-33%3B 54.3%25 identity in 221 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene5074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5022 SCO5023 SCO5023 SCK15.25 SCK15.25 5456892 5457902 + hypothetical protein SCK15.25%2C possible hypothetical protein%2C len: 336 aa%3B similar to TR:CAB77312 (EMBL:AL160312) Streptomyces coelicolor hypothetical protein SCD35.28c%2C 361 aa%3B fasta scores: opt: 890 z-score: 972.2 E(): 0%3B 47.3%25 identity in 357 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene5075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5023 SCO5024 SCO5024 SCK15.26 SCK15.26 5458019 5458891 + oxidoreductase SCK15.26%2C possible oxidoreductase%2C len: 290 aa%3B similar to TR:Q9UXP0 (EMBL:AJ011519) Methanolobus tindarius F420-dependent N5%2CN10-methylene-tetrahydromethanopterin reductase%2C FfdA%2C 326 aa%3B fasta scores: opt: 323 z-score: 369.8 E(): 4e-13%3B 28.3%25 identity in 240 aa overlap gene gene5076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5024 SCO5025 SCO5025 SCK15.27 SCK15.27 5458994 5459911 + transcriptional regulator SCK15.27%2C possible transcriptional regulator%2C len: 305 aa%3B similar to TR:Q9RJS9 (EMBL:AL132707) Streptomyces coelicolor transcriptional regulator SCF51.06 334 aa%3B fasta scores: opt: 166 z-score: 190.7 E(): 0.0037%3B 27.3%25 identity in 289 aa overlap and to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA%2C 253 aa%3B fasta scores: opt: 174 z-score: 201.3 E(): 0.00096%3B 35.5%25 identity in 107 aa overlap. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and possible helix-turn-helix at residues 11..32 (+2.74 SD) gene gene5077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5025 SCO5026 SCO5026 SCK15.28 SCK15.28 5459908 5460726 + hypothetical protein SCK15.28%2C hypothetical protein%2C len: 272 aa%3B similar to TR:O06593 (EMBL:Z95586) Mycobacterium tuberculosis hypothetical 27.9 kD protein MTCY336.07c%2C 252 aa%3B fasta scores: opt: 968 z-score: 1156.3 E(): 0%3B 57.5%25 identity in 254 aa overlap gene gene5078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5026 SCO5027 SCO5027 SCK15.29c SCK15.29c 5460757 5461950 - hypothetical protein SCK15.29c%2C hypothetical protein%2C len: 397 aa%3B similar to TR:Q9RKN1 (EMBL:AL121850) Streptomyces coelicolor hypothetical 37.4 kD protein (fragment) SCC78.05%2C 347 aa%3B fasta scores: opt: 180 z-score: 199.8 E(): 0.0012%3B 28.6%25 identity in 360 aa overlap gene gene5079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5027 SCO5028 SCO5028 SCK7.01 SCK7.01 5463012 5464337 + ATP-binding protein SCK7.01%2C possible ATP-binding protein%2C len: 441 aa%3B similar to TR:Q9X792 (EMBL:AL049491) Mycobacterium leprae ATP-binding protein MLCB1222.20%2C 433 aa%3B fasta scores: opt: 2024 z-score: 2236.8 E(): 0%3B 72.2%25 identity in 428 aa overlap. Contains and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5028 SCO5029 SCO5029 SCK7.02 SCK7.02 5464767 5465483 + hypothetical protein SCK7.02%2C possible hypothetical protein%2C len: 238 aa%3B similar to C-terminal region of TR:CAB93446 (EMBL:AL357591) Streptomyces coelicolor hypothetical 16.0 kDa protein SCC53.17%2C 154 aa%3B fasta scores: opt: 477 z-score: 484.5 E(): 1.6e-19%3B 64.4%25 identity in 101 aa overlap. Contains possible N-terminal region signal peptide sequence and possible coiled-coil region at aprox. residues 82..123 gene gene5081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5029 SCO5030 SCO5030 SCK7.03 SCK7.03 5465646 5467043 + hypothetical protein SCK7.03%2C possible integral membrane protein%2C len: 465 aa%3B similar to SW:Y205_MYCTU (EMBL:AL021928) Mycobacterium tuberculosis hypothetical 38.0 kDa protein MTV033.13%2C 367 aa%3B fasta scores: opt: 892 z-score: 833.4 E(): 0%3B 41.1%25 identity in 343 aa overlap. Contains Pfam match to entry PF01594 UPF0118%2C Domain of unknown function DUF20 and possible hydrophobic membrane spanning regions gene gene5082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5030 SCO5031 SCO5031 ahpD ahpD 5467332 5467868 - hypothetical protein SCK7.04c%2C ahpD%2C alkyl hydroperoxide reductase system hypothetical protein%2C len: 178 aa%3B identical to previously sequenced TR:Q9RN73 (EMBL:AF186371) Streptomyces coelicolor A3(2) AhpD%2C 178 aa gene gene5083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5031 SCO5032 SCO5032 ahpC ahpC 5467875 5468429 - alkyl hydroperoxide reductase SCK7.05c%2C ahpC%2C alkyl hydroperoxide reductase%2C len:184 aa%3B identical to previously seqeunced TR:Q9RN72 (EMBL:AF186371) Streptomyces coelicolor A3(2) AhpC%2C 184 aa. Contains Pfam match to entry PF00578 AhpC-TSA%2C AhpC/TSA family gene gene5084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5032 SCO5033 SCO5033 oxyR oxyR 5468567 5469505 + hydrogen peroxide sensing regulator SCK7.06%2C oxyR%2C hydrogen peroxide sensing regulator%2C len: 312 aa%3B identical to previously sequenced TR:Q9RN71 (EMBL:AF186371) Streptomyces coelicolor A3(2) hydrogen peroxide sensing regulator OxyR%2C 313 aa. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry S00044 Bacterial regulatory proteins%2C lysR family signature. Also contains possible helix-turn-helix motif at residues 23..44 (+3.89 SD) gene gene5085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5033 SCO5034 SCO5034 SCK7.07c SCK7.07c 5469633 5471969 - hypothetical protein SCK7.07c%2C possible integral membrane protein%2C len: 778 aa%3B similar to TR:AAF74504 (EMBL:M34538) Streptomyces clavuligerus hypothetical 42.6 kDa protein (fragment) 407 aa%3B fasta scores: opt: 509 z-score: 559.6 E(): 1.1e-23%3B 31.5%25 identity in 413 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5034 SCO5035 SCO5035 SCK7.08c SCK7.08c 5471972 5472661 - ABC transporter ATP-binding protein SCK7.08c%2C possible ABC transporter ATP-binding protein%2C len: 229 aa%3B similar to TR:CAB81857 (EMBL:AL161691) Streptomyces coelicolor ABC transporter ATP-binding protein SCD40A.12c%2C 246 aa%3B fasta scores: opt: 597 z-score: 668.0 E(): 9.7e-30%3B 47.6%25 identity in 206 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5035 SCO5036 SCO5036 SCK7.09c SCK7.09c 5472658 5473182 - hypothetical protein SCK7.09c%2C hypothetical protein%2C len: 174 aa%3B similar to TR:O50432 (EMBL:AL010186) Mycobacterium tuberculosis hypothetical 21.1 kDa protein MTV005.12c%2C 189 aa%3B fasta scores: opt: 183 z-score: 238.8 E(): 7.8e-06%3B 30.1%25 identity in 186 aa overlap gene gene5088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5036 SCO5037 SCO5037 SCK7.10c SCK7.10c 5473366 5473671 - hypothetical protein SCK7.10c%2C unknown%2C len: 101 aa. Highly hydrophilic. Also high in G+C content (80.52 %25) gene gene5089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5037 SCO5038 SCO5038 SCK7.11c SCK7.11c 5473668 5474606 - hypothetical protein SCK7.11c%2C possible integral membrane protein%2C len: 312 aa%3B similar to TR:Q9RDB7 (EMBL:AL136058) Streptomyces coelicolor membrane protein SCE20.08c%2C 383 aa%3B fasta scores: opt: 467 z-score: 517.9 E(): 2.2e-21%3B 31.2%25 identity in 301 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5038 SCO5039 SCO5039 SCK7.12 SCK7.12 5475026 5477176 + penicillin-binding protein SCK7.12%2C possible penicillin-binding protein%2C len: 773 aa%3B similar to TR:CAB88838 (EMBL:AL353832) Streptomyces coelicolor probable penicillin-binding protein SCE6.34%2C 756 aa%3B fasta scores: opt: 1080 z-score: 911.6 E(): 0%3B 46.0%25 identity in 733 aa overlap and to SW:PBPD_BACSU (EMBL:U11882) Bacillus subtilis penicillin-binding protein 4 precursor PbpD%2C 624 aa%3B fasta scores: opt: 513 z-score: 438.2 E(): 6.1e-17%3B 28.7%25 identity in 582 aa overlap. Contains Pfam matches to entries PF00912 Transglycosyl%2C Transglycosylase and PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and 2x matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5039 SCO5040 SCO5040 SCK7.13c SCK7.13c 5477315 5479528 - hypothetical protein SCK7.13c%2C conserved hypothetical protein%2C len: 737 aa%3B similar to TR:Q9ZBJ0 (EMBL:AL035161) Streptomyces coelicolor conserved hypothetical protein SC9C7.20%2C 860 aa%3B fasta scores: opt: 1430 z-score: 1211.3 E(): 0%3B 37.5%25 identity in 787 aa overlap. Contains match to Prosite entry%2C TTA leucine codon%2C possible target for bldA regulation and 3x degenerate repeat (P/A)(D/G)GGQ gene gene5092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5040 SCO5041 SCO5041 SCK7.14c SCK7.14c 5479825 5480535 - hypothetical protein SCK7.14%2C hypothetical protein%2C len: 236 aa%3B similar to TR:O83033 (EMBL:AB016934) Streptomyces wedmorensis FomD protein%2C 209 aa%3B fasta scores: opt: 282 z-score: 320.1 E(): 2.3e-10%3B 34.5%25 identity in 197 aa overlap gene gene5093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5041 SCO5042 SCO5042 fumC fumC 5480624 5482009 - fumarate hydratase class II family (does not require metal)%3B tetrameric enzyme%3B fumarase C%3B reversibly converts (S)-malate to fumarate and water%3B functions in the TCA cycle gene gene5094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5042 SCO5043 SCO5043 SCK7.16c SCK7.16c 5482101 5483561 - hydrolase membrane protein SCK7.16c%2C probable hydrolase (membrane protein)%2C len: 486 aa%3B N-terminal similar to SW:APX_STRGR Streptomyces griseus aminopeptidase (EC 3.4.11.-)%2C 284 aa%3B fasta scores: opt: 967 z-score: 1057.3 E(): 0%3B 53.7%25 identity in 283 aa overlap and C-terminal region similar to TR:O69311 (EMBL:D84193) Streptomyces lividans chitinase (EC 3.2.1.14) ChiB%2C 610 aa%3B blastp scores: Score %3D 87 (30.6 bits)%2C Expect %3D 2.1%2C P %3D 0.87%3B Identities %3D 46/159 (28%25)%2C Positives %3D 60/159 (37%25). Contains possible hydrophobic membrane spanning region gene gene5095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5043 SCO5044 SCO5044 fumB fumB 5483742 5485418 - fumarate hydratase class I SCK7.17c%2C fumB%2C fumarate hydratase class I%2C len: 558 aa%3B similar to SW:FUMB_ECOLI (EMBL:M27058) Escherichia coli fumarate hydratase class I%2C anaerobic (EC 4.2.1.2) FumB%2C 548 aa%3B fasta scores: opt: 2386 z-score: 2782.7 E(): 0%3B 64.9%25 identity in 539 aa overlap. Contains Pfam match to entry PF00206 lyase_1%2C Lyase and match to Prosite entry PS00163 Fumarate lyases signature gene gene5096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5044 SCO5045 SCO5045 SCK7.18 SCK7.18 5485654 5486337 + hypothetical protein SCK7.18%2C conserved hypothetical protein%2C len: 227 aa%3B similar to TR:CAB88834 (EMBL:AL353832) Streptomyces coelicolor hypothetical 30.8 kDa protein SCE6.30c%2C 277 aa%3B fasta scores: opt: 403 z-score: 468.8 E(): 1.2e-18%3B 38.6%25 identity in 220 aa overlap gene gene5097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5045 SCO5046 SCO5046 SCK7.19 SCK7.19 5486443 5486820 + hypothetical protein SCK7.19%2C wblI%2C len: 125 aa%3B identical to previously sequenced TR:Q9X953 (EMBL:AJ239088) Streptomyces coelicolor hypothetical 13.9 kDa protein WblI%2C 125 aa and to TR:O88103 (EMBL:AJ010601) Streptomyces coelicolor WhiD protein%2C 112 aa%3B fasta scores: opt: 297 z-score: 395.0 E(): 1.6e-14%3B 46.7%25 identity in 105 aa overlap gene gene5098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5046 SCO5047 SCO5047 glpX glpX 5487077 5488108 - fructose 1%2C6-bisphosphatase II type II fructose 1%2C6-bisphosphatae%3B in Escherichia coli this protein forms a dimer and binds manganese gene gene5099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5047 SCO5048 SCO5048 SCK7.21 SCK7.21 5488244 5488768 + hypothetical protein SCK7.21%2C possible hypothetical protein%2C len: 174 aa. Contains possible N-terminal signal peptide sequence gene gene5100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5048 SCO5049 SCO5049 SCK7.22c SCK7.22c 5488832 5489422 - hypothetical protein SCK7.22%2C hypothetical protein%2C len: 196 aa%3B similar to TR:P75894 (EMBL:AE000202) Escherichia coli hypothetical protein%2C 196 aa%3B fasta scores: opt: 466 z-score: 572.4 E(): 2e-24%3B 40.6%25 identity in 192 aa overlap and to SW:YDFN_BACSU (EMBL:AB001488) Bacillus subtilis NAD(P)H nitroreductase YdfN%2C 206 aa%3B fasta scores: opt: 133 z-score: 170.9 E(): 0.047%3B 23.1%25 identity in 199 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase%2C Nitroreductase family. Similar also to TR:Q9FBV0 (EMBL:AL391072) Streptomyces coelicolor nitroreductase SC9A4.03c%2C 202 aa%3B fasta scores: opt: 599 Z-score: 706.0 E(): 1.1e-31%3B 49.474%25 identity in 190 aa overlap gene gene5101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5049 SCO5050 SCO5050 SCK7.23 SCK7.23 5489640 5490971 + nucleotide-sugar dehydrogenase SCK7.23%2C possible nucleotide-sugar dehydrogenase%2C len: 443 aa%3B similar to TR:CAB82012 (EMBL:AL161755) Streptomyces coelicolor nucleotide-sugar dehydrogenase SCD63.05c%2C 405 aa%3B fasta scores: opt: 736 z-score: 812.9 E(): 0%3B 36.2%25 identity in 423 aa overlap. Contains Pfam match to entry PF00984 UDPG_MGDP_dh%2C UDP-glucose/GDP-mannose dehydrogenase family gene gene5102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5050 SCO5051 SCO5051 SCK7.24 SCK7.24 5490968 5492431 + glycosyltransferase SCK7.24%2C possible glycosyltransferase%2C len: 487 aa%3B similar to SW:NODC_RHIME (EMBL:X01649) Rhizobium meliloti N-acetylglucosaminyltransferase (EC 2.4.1.-) NodC%2C 426 aa%3B fasta scores: opt: 377 z-score: 447.1 E(): 2e-17%3B 29.6%25 identity in 433 aa overlap. Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases and possible hydrophobic membrane spanning regions gene gene5103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5051 SCO5052 SCO5052 SCK7.25 SCK7.25 5492428 5492535 + hypothetical protein SCK7.25%2C possible membrane protein%2C len: 35 aa. Doubtful CDS. Contains possible hydrophobic membrane spanning region gene gene5104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5052 SCO5053 SCO5053 SCK7.26 SCK7.26 5492532 5494091 + hypothetical protein SCK7.26%2C possible hypothetical protein%2C len: 519 aa. Contains possible N-terminal region signal peptide sequence gene gene5105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5053 SCO5054 SCO5054 SCK7.27 SCK7.27 5494102 5494416 + hypothetical protein SCK7.27%2C unknown%2C len: 104 aa gene gene5106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5054 SCO5055 SCO5055 SCK7.28c SCK7.28c 5494413 5494679 - exodeoxyribonuclease VII small subunit catalyzes the bidirectional exonucleolytic cleavage of DNA gene gene5107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5055 SCO5056 SCO5056 xseA xseA 5494689 5495897 - exodeoxyribonuclease VII large subunit bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides gene gene5108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5056 SCO5057 SCO5057 SCK7.30c SCK7.30c 5496474 5497856 - amino acid permease SCK7.30c%2C possible amino acid permease%2C len: 460 aa%3B similar to SW:MMUP_ECOLI (EMBL:D83536) Escherichia coli probable S-methylmethionine permease MmuP%2C 475 aa%3B fasta scores: opt: 345 z-score: 390.5 E(): 2.8e-14%3B 23.3%25 identity in 408 aa overlap and to TR:P74848 (EMBL:X99945) Salmonella typhimurium amino acid permease YeeF like protein%2C 448 aa%3B fasta scores: opt: 705 z-score: 792.4 E(): 0%3B 32.0%25 identity in 416 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and possible hydrophobic membrane spanning regions gene gene5109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5057 SCO5058 SCO5058 ispH ispH 5497985 5499001 + 4-hydroxy-3-methylbut-2-enyl diphosphate reductase catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)%3B functions in the nonmevalonate isoprenoid biosynthesis pathway gene gene5110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5058 SCO5059 SCO5059 ppgK ppgK 5499055 5499795 + polyphosphate glucokinase SCBAC20F6.02%2C ppgK%2C polyphosphate glucokinase%2C len: 246 aa%3B highly similar to SW:PPGK_MYCTU (EMBL:U44834) Mycobacterium tuberculosis polyphosphate glucokinase (EC 2.7.1.63) PpgK or RV2702 or MTCY05A6.23%2C 265 aa%3B fasta scores: opt: 912 Z-score: 1042.8 bits: 200.5 E(): 1.7e-50%3B 57.322%25 identity in 239 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family gene gene5111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5059 SCO5060 SCO5060 SCBAC20F6.03c SCBAC20F6.03c 5499806 5500408 - hypothetical protein SCBAC20F6.03c%2C possible integral membrane protein%2C len: 200 aa. Contains possible hydrophobic membrane spanning regions and high G+C content in N-terminal region gene gene5112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5060 SCO5061 SCO5061 ychF ychF 5500594 5501682 + GTP-dependent nucleic acid-binding protein EngD translation-associated GTPase%3B the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3)%3B fluorescence spectroscopy revealed nucleic acid binding%3B the yeast protein YBR025c interacts with the translation elongation factor eEF1 gene gene5113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5061 SCO5062 SCO5062 SCBAC20F6.05c SCBAC20F6.05c 5501804 5502196 - hypothetical protein SCBAC20F6.05c%2C hypothetical protein%2C len: 130 aa%3B similar to TR:Q9X8E7 (EMBL:AL049573) Streptomyces coelicolor hypothetical 16.4 kDa protein SCE39.24%2C 148 aa%3B fasta scores: opt: 257 Z-score: 327.8 bits: 66.5 E(): 1.1e-10%3B 39.394%25 identity in 132 aa overlap gene gene5114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5062 SCO5063 SCO5063 SCBAC20F6.06c SCBAC20F6.06c 5502196 5502447 - hypothetical protein SCBAC20F6.06c%2C hypothetical protein%2C len: 83 aa%3B similar to TR:Q9XAG7 (EMBL:AL079356) Streptomyces coelicolor hypothetical 8.8 kDa protein SC6G9.07%2C 84 aa%3B fasta scores: opt: 167 Z-score: 224.6 bits: 45.9 E(): 6.3e-05%3B 43.103%25 identity in 58 aa overlap gene gene5115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5063 SCO5064 SCO5064 SCBAC20F6.07 SCBAC20F6.07 5502446 5504848 + hypothetical protein SCBAC20F6.07%2C possible bifunctional protein%2C len: 800 aa%3B N-terminal domain does not present similarity to any known protein and C-terminal half is similar to the C-terminal domain of may prokaryotic helicases%2C e.g. TR:Q9CE08 (EMBL:AE006434) Lactococcus lactis (subsp. lactis) SWI/SNF family helicase Snf%2C 1034 aa%3B fasta scores: opt: 317 Z-score: 332.6 bits: 72.8 E(): 6.1e-11%3B 29.817%25 identity in 436 aa overlap. Contains Pfam match to entry PF00176 SNF2_N%2C SNF2 and others N-terminal domain and Pfam match to entry PF00271 helicase_C%2C Helicase conserved C-terminal domain gene gene5116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5064 SCO5065 SCO5065 SCBAC20F6.08c SCBAC20F6.08c 5504937 5507768 - transcriptional regulator SCBAC20F6.08c%2C possible transcriptional regulator%2C len: 943 aa%3B similar to many transcriptional regulatory proteins%2C e.g. TR:Q9XAT8 (EMBL:U95170) Rhodococcus erythropolis ThcG%2C 927 aa%3B fasta scores: opt: 1419 Z-score: 1371.5 bits: 265.1 E(): 8.4e-69%3B 35.446%25 identity in 931 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains possible helix-turn-helix motif at residues 893..914 (+3.76 SD) gene gene5117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5065 SCO5066 SCO5066 SCBAC20F6.09 SCBAC20F6.09 5508078 5508992 + beta-lactamase SCBAC20F6.09%2C possible beta-lactamase%2C len: 304 aa%3B similar to TR:Q9X7X2 (EMBL:AL049485) Streptomyces coelicolor beta-lactamase SC6E5.26c%2C 310 aa%3B fasta scores: opt: 598 Z-score: 696.3 bits: 136.9 E(): 3.4e-31%3B 53.115%25 identity in 305 aa overlap and to SW:BLA1_XANMA (EMBL:X75074) Xanthomonas maltophilia metallo-beta-lactamase L1 precursor (beta-lactamase%2C type II) (EC 3.5.2.6)%2C 290 aa%3B fasta scores: opt: 146 Z-score: 175.9 bits: 40.6 E(): 0.033%3B 25.952%25 identity in 289 aa overlap. Contains Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily and match to Prosite entry PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site gene gene5118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5066 SCO5067 SCO5067 SCBAC20F6.10 SCBAC20F6.10 5509015 5510508 + carboxylesterase SCBAC20F6.10%2C probable carboxylesterase%2C len: 497 aa%3B similar to SW:PNBA_BACSU (EMBL:U06089) Bacillus subtilis para-nitrobenzyl esterase (EC 3.1.1.*) PnbA%2C 489 aa%3B fasta scores: opt: 784 Z-score: 827.6 bits: 162.6 E(): 1.6e-38%3B 37.205%25 identity in 508 aa overlap. Contains 2x Pfam matches to entry PF00135 COesterase%2C Carboxylesterase and match to Prosite entry PS00122 Carboxylesterases type-B serine active site gene gene5119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5067 SCO5068 SCO5068 SCBAC20F6.11c SCBAC20F6.11c 5510516 5511115 - TetR family transcriptional regulator SCBAC20F6.11c%2C possible tetR-family transcriptional regulator%2C len: 199 aa%3B similar to many actinomycetes tetR-family transcriptional regulators%2C e.g. TR:Q9RJL5 (EMBL:AL121849) Streptomyces coelicolor tetR-family transcriptional regulator SCF6.16%2C 194 aa%3B fasta scores: opt: 419 Z-score: 483.9 bits: 96.4 E(): 2.3e-19%3B 38.095%25 identity in 189 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 36..57 (+4.64 SD) gene gene5120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5068 SCO5069 SCO5069 SCBAC20F6.12 SCBAC20F6.12 5511271 5512227 + oxidoreductase SCBAC20F6.12%2C possible oxidoreductase%2C len: 318 aa%3B similar to many oxidoreductases/dehydratases%2C e.g. TR:Q9WX20 (EMBL:AL079345) Streptomyces coelicolor dehydrogenase SCE68.12c%2C 318 aa%3B fasta scores: opt: 998 Z-score: 1062.9 bits: 204.9 E(): 1.3e-51%3B 52.997%25 identity in 317 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene5121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5069 SCO5070 SCO5070 SCBAC20F6.13c SCBAC20F6.13c 5512268 5513452 - hydroxylacyl-CoA dehydrogenase SCBAC20F6.13c%2C ORFB hydroxylacyl-CoA dehydrogenase%2C len: 394 aa%3B identical to previously sequenced TR:Q53924 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORFB%2C 394 aa. There is an alternative start codon 120 base pairs upstream of the previously sequenced one gene gene5122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5070 SCO5071 SCO5071 SCBAC20F6.14c SCBAC20F6.14c 5513809 5514249 - hydroxylacyl-CoA dehydrogenase SCBAC20F6.14c%2C ORFA hydroxylacyl-CoA dehydrogenase%2C len: 146 aa%3B identical to previously sequenced TR:Q53925 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORFA%2C 146 aa gene gene5123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5071 SCO5072 SCO5072 SCBAC20F6.15 SCBAC20F6.15 5514323 5515246 + hydroxylacyl-CoA dehydrogenase SCBAC20F6.15%2C ORF1 hydroxylacyl-CoA dehydrogenase%2C len: 307 aa%3B identical to previously sequenced TR:Q53926 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORF1%2C 307 aa. Contains Pfam matches to entries PF02737 3HCDH_N%2C 3-hydroxyacyl-CoA dehydrogenase%2C NAD binding domain and PF00725 3HCDH%2C 3-hydroxyacyl-CoA dehydrogenase%2C C-terminal domain. Contains possible hydrophobic membrane spanning region gene gene5124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5072 SCO5073 SCO5073 SCBAC20F6.16 SCBAC20F6.16 5515243 5516232 + oxidoreductase SCBAC20F6.16%2C ORF2%2C possible oxidoreductase%2C len: 329 aa%3B identical to previously sequenced TR:Q53927 (EMBL:X62373) Streptomyces coelicolor genes for hydroxylacyl-CoA dehydrogenase ORF2%2C 329 aa. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature gene gene5125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5073 SCO5074 SCO5074 SCBAC20F6.17 SCBAC20F6.17 5516299 5516943 + dehydratase SCBAC20F6.17%2C possible dehydratase%2C len: 214 aa%3B identical to previously sequenced TR:Q53928 (EMBL:X62373) Streptomyces coelicolor ORF 3%2C 214 aa. Similar to TR:Q56172 (EMBL:L37334) dehydratase from granaticin biosynthesis cluster of Streptomyces violaceoruber Tu22 (221 aa) fasta scores%3B opt: 349%2C Z-score: 400.9%2C E(): 1.1e-14%2C 35.465%25 identity (37.195%25 ungapped) in 172 aa overlap. gene gene5126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5074 SCO5075 SCO5075 ORF4 ORF4 5516977 5517897 + oxidoreductase SCBAC28G1.01%2C possible oxidoreductase%2C previously sequenced as ORF4%2C len: 167 aa%3B identical to C-terminal region of previously sequenced TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF4%2C 306 aa%3B fasta scores: opt: 1029 Z-score: 1146.7 bits: 219.4 E(): 2.9e-56%3B 95.808%25 identity in 167 aa overlap. Contains match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature~SCBAC20F6.18%2C ORF4%2C possible oxidoreductase%2C len: 170 aa%3B identical to N-terminal region of the previously sequenced TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF 4%2C 306 aa. Contains match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature gene gene5127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5075 SCO5076 SCO5076 actVA1 actVA1 5517894 5519495 + hypothetical protein SCBAC28G1.02%2C actVA1%2C probable integral membrane protein%2C len: 533 aa%3B identical to previously sequenced TR:Q53903 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster%2C ActVA1%2C 533 aa. Contains possible hydrophobic membrane spanning regions gene gene5128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5076 SCO5077 SCO5077 actVA2 actVA2 5519497 5519892 + hypothetical protein SCBAC28G1.03%2C actVA2%2C hypothetical protein%2C len: 131 aa%3B identical to previously sequenced TR:Q53904 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster%2C ActVA2%2C 131 aa gene gene5129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5077 SCO5078 SCO5078 actVA3 actVA3 5519987 5520832 + hypothetical protein SCBAC28G1.04%2C actVA3%2C hypothetical protein%2C len: 281 aa%3B identical to previously sequenced TR:Q53905 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster%2C ActVA3%2C 281 aa gene gene5130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5078 SCO5079 SCO5079 actVA4 actVA4 5520857 5521741 + hypothetical protein SCBAC28G1.05%2C actVA4%2C conserved hypothetical protein%2C len: 294 aa%3B identical to previously sequenced TR:Q53906 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster%2C ActVA4%2C 294 aa gene gene5131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5079 SCO5080 SCO5080 actVA5 actVA5 5521738 5522883 + hydrolase SCBAC28G1.06%2C actVA5%2C possible hydrolase%2C len: 381 aa%3B identical to previously sequenced TR:Q53907 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster%2C ActVA5%2C 381 aa and similar to TR:Q9F0J3 (EMBL:AF218066) Streptomyces arenae hydrolase NcnH%2C 405 aa%3B fasta scores: opt: 1391 Z-score: 1521.5 bits: 290.3 E(): 3.9e-77%3B 56.522%25 identity in 368 aa overlap gene gene5132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5080 SCO5081 SCO5081 actVA6 actVA6 5522876 5523217 + hypothetical protein SCBAC28G1.07%2C actVA6%2C hypothetical protein%2C len: 113 aa%3B identical to previously sequenced TR:Q53908 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster%2C ActVA6%2C 113 aa and similar to SW:TCMH_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin polyketide synthesis hydroxylase TcmH%2C 112 aa%3B fasta scores: opt: 193 Z-score: 247.6 bits: 51.0 E(): 3.5e-06%3B 43.210%25 identity in 81 aa overlap gene gene5133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5081 SCO5082 SCO5082 actII-1 actII-1 5523183 5523962 - transcriptional regulator SCBAC28G1.08c%2C actII-1%2C probable transcriptional regulatory protein%2C len: 259 aa%3B identical to previously sequenced TR:Q53901 (EMBL:M64683) Streptomyces coelicolor ORF1-4 (ActII)%2C 259 aa. Contains Pfam matches to entries PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and PF02909 tetR_C%2C Tetracyclin repressor%2C C-terminal all-alpha domain and possible helix-turn-helix motif at residues 53..73 (+2.78 SD) gene gene5134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5082 SCO5083 SCO5083 actII-2 actII-2 5524073 5525809 + actinorhodin transporter SCBAC28G1.09%2C actII-2%2C probable actinorhodin transporter%2C len: 578 aa%3B identical to previously sequenced SW:AC22_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhodin transporter ActII-2%2C 578 aa. Contains possible hydrophobic membrane spanning regions and a leucine TTA codon%2C possible target for bldA regulation gene gene5135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5083 SCO5084 SCO5084 actII-3 actII-3 5525809 5527944 + hypothetical protein SCBAC28G1.10%2C actII-3%2C membrane protein%2C len: 711 aa%3B identical to previously sequenced SW:MMLA_STRCO (EMBL:M64683) Streptomyces coelicolor membrane protein ActII-3%2C 711 aa. Contains possible hydrophobic membrane spanning regions gene gene5136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5084 SCO5085 SCO5085 actII-4 actII-4 5528094 5528861 + actinorhodin operon activator protein SCBAC28G1.11%2C actII-4%2C actinorhodin cluster activator protein%2C len: 255 aa%3B identical to previously sequenced SW:AC24_STRCO (EMBL:M64683) Streptomyces coelicolor actinorhodin operon activator protein ActII-4%2C 255 aa. Contains a leucine TTA codon%2C possible target for bldA regulation gene gene5137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5085 SCO5086 SCO5086 actIII actIII 5528935 5529720 - ketoacyl reductase SCBAC28G1.12c%2C actIII%2C ketoacyl reductase%2C len: 261 aa%3B identical to previously sequenced SW:ACT3_STRCO (EMBL:M19536) Streptomyces coelicolor ketoacyl reductase ActIII%2C 261 aa. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene5138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5086 SCO5087 SCO5087 actIORF1 actIORF1 5529801 5531204 + actinorhodin polyketide beta-ketoacyl synthase subunit alpha SCBAC28G1.13%2C actIORF1%2C actinorhodin polyketide beta-ketoacyl synthase alpha subunit%2C len: 467 aa%3B identical to C-terminal region of SW:KASA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide beta-ketoacyl synthase 1 ActI ORF1%2C 424 aa. Previously sequenced start codon at residue 44 of this sequence. Also similar to TR:CAB45606 (EMBL:AL079356) Streptomyces coelicolor polyketide beta-ketoacyl synthase alpha (WhiE locus) SC6G9.15%2C 424 aa%3B fasta scores: opt: 1706 Z-score: 1660.2 bits: 316.4 E(): 9.5e-87%3B 61.871%25 identity in 417 aa overlap. Contains Pfam matches to entries PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C N-terminal domain and PF02801 ketoacyl-synt_C%2C Beta-ketoacyl synthase%2C C-terminal domain and match to Prosite entry PS00606 Beta-ketoacyl synthases active site gene gene5139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5087 SCO5088 SCO5088 actIORF2 actIORF2 5531201 5532424 + actinorhodin polyketide beta-ketoacyl synthase subunit beta SCBAC28G1.14%2C actIORF2%2C actinorhodin polyketide beta-ketoacyl synthase beta subunit (also known as chain length factor)%2C len: 407 aa%3B identical to previously sequenced SW:KASB_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide beta-ketoacyl synthase 2 ActI ORF2%2C 407 aa. Contains Pfam matches to entries PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C N-terminal domain and PF02801 ketoacyl-synt_C%2C Beta-ketoacyl synthase%2C C-terminal domain gene gene5140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5088 SCO5089 SCO5089 actIORF3 actIORF3 5532449 5532709 + actinorhodin polyketide synthase SCBAC28G1.15%2C actIORF3%2C actinorhodin polyketide synthase acyl carrier protein%2C len: 86 aa%3B identical to previously sequenced SW:ACPA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein ActI ORF3%2C 86 aa. Contains Pfam match to entry PF00550 pp-binding%2C Phosphopantetheine attachment site and match to Prosite entry PS00012 Phosphopantetheine attachment site gene gene5141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5089 SCO5090 SCO5090 actVII actVII 5532706 5533656 + actinorhodin polyketide synthase bifunctional cyclase/dehydratase SCBAC28G1.16%2C actVII%2C actinorhodin polyketide synthase bifunctional cyclase/dehydratase%2C len: 316 aa%3B identical to previously sequenced SW:CYPK_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide synthase bifunctional cyclase/dehydratase ActI ORF4%2C 316 aa gene gene5142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5090 SCO5091 SCO5091 actIV actIV 5533653 5534546 + cyclase SCBAC28G1.17%2C actIV%2C cyclase%2C len: 297 aa%3B identical to previously sequenced TR:Q02057 (EMBL:X63449) Streptomyces coelicolor dehydrogenase ActI ORF5%2C 297 aa. Contains Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily gene gene5143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5091 SCO5092 SCO5092 actVB actVB 5534558 5535091 + actinorhodin polyketide dimerase SCBAC28G1.18%2C actVB%2C actinorhodin polyketide possible dimerase%2C len: 177 aa%3B identical to previously sequenced SW:DIM6_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide dimerase ActI ORF6%2C ActVB%2C 177 aa Contains Pfam match to entry PF01613 Flavin_Reduct%2C Flavin reductase like domain gene gene5144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5092 SCO5093 SCO5093 ORF7 ORF7 5535110 5535607 - mini-circle protein SCBAC28G1.19c%2C ORF7%2C mini-circle protein%2C len: 165 aa%3B identical to previously sequenced TR:Q9X9V2 (EMBL:Y18817) Streptomyces coelicolor A3(2) mini-circle protein ORF7%2C 165 aa gene gene5145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5093 SCO5094 SCO5094 ORF8 ORF8 5535661 5536287 - methyltransferase SCBAC28G1.20c%2C ORF8%2C methyltransferase%2C len: 208 aa%3B identical to previously sequenced TR:Q9X9V1 (EMBL:Y18817) Streptomyces coelicolor A3(2) methyltransferase ORF8%2C 208 aa gene gene5146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5094 SCO5095 SCO5095 ORF9 ORF9 5536422 5536994 + DNA-binding protein SCBAC28G1.21%2C ORF9%2C probable DNA-binding protein%2C len: 190 aa%3B identical to previously sequenced as TR:Q9X9V0 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 20.6 kDa protein ORF9%2C 190 aa and similar to TR:O86784 (EMBL:AL031317) Streptomyces coelicolor SC6G4.21%2C 202 aa%3B fasta scores: opt: 642 Z-score: 656.2 bits: 128.2 E(): 7.9e-31%3B 53.968%25 identity in 189 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and possible helix-turn-helix motif at residues 25..46 (+6.01 SD) gene gene5147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5095 SCO5096 SCO5096 SCBAC28G1.22c SCBAC28G1.22c 5537246 5538175 - LysR family transcriptional regulator SCBAC28G1.22c%2C LysR-family transcriptional regulatory protein%2C len: 309 aa%3B identical to previously sequenced TR:Q9X9U9 (EMBL:Y18817) Streptomyces coelicolor A3(2) transcriptional regulator of LysR family%2C 307 aa. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Also contains a possible helix-turn-helix motif at residues 22..43 (+5.22 SD) gene gene5148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5096 SCO5097 SCO5097 SCBAC28G1.23 SCBAC28G1.23 5538270 5539100 + short-chain oxidoreductase SCBAC28G1.23%2C short-chain oxidoreductase%2C len: 276 aa%3B identical to previously sequenced TR:Q9X9U8 (EMBL:Y18817) Streptomyces coelicolor A3(2) oxidoreductase of short-chain%2C 276 aa. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene5149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5097 SCO5098 SCO5098 ORF12 ORF12 5539158 5539622 + hypothetical protein SCBAC28G1.24%2C possible integral membrane protein%2C len: 154 aa%3B identical in its C-terminal domain to TR:Q9X9U7 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 11.9 kDa protein ORF11%2C 113 aa. Contains possible hydrophobic membrane spanning regions and 10x degenerate repeat at N-terminal region: M(P/V). Alternative start codon in previously sequence EMBL entrance after the repeat region at residue 42 gene gene5150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5098 SCO5099 SCO5099 SCBAC28G1.25 SCBAC28G1.25 5539732 5540862 + hypothetical protein SCBAC28G1.25%2C possible membrane protein%2C len: 376 aa. Contains possible hydrophobic membrane spanning regions gene gene5151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5099 SCO5100 SCO5100 SCBAC28G1.26 SCBAC28G1.26 5541010 5541762 + GntR family transcriptional regulator SCBAC28G1.26%2C possible gntR-family regulatory protein%2C len: 250 aa%3B low similarity to SW:FARR_ECOLI (EMBL:X15790) Escherichia coli fatty acid responsive regulator (P30 protein) FarR%2C 240 aa%3B fasta scores: opt: 206 Z-score: 237.6 bits: 51.4 E(): 1.3e-05%3B 25.926%25 identity in 243 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene5152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5100 SCO5101 SCO5101 SCBAC28G1.27 SCBAC28G1.27 5542208 5542399 + hypothetical protein SCBAC28G1.27%2C conserved hypothetical protein%2C len: 63 aa%3B similar to TR:Q9HTF6 (EMBL:AE004953) Pseudomonas aeruginosa hypothetical protein PA5408%2C 58 aa%3B fasta scores: opt: 146 Z-score: 225.2 bits: 45.1 E(): 6.2e-05%3B 45.652%25 identity in 46 aa overlap gene gene5153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5101 SCO5102 SCO5102 SCBAC28G1.28 SCBAC28G1.28 5542475 5542909 + mutT-like protein SCBAC28G1.28%2C possible mutT-like protein%2C len: 144 aa%3B similar to SW:MUTT_ECOLI (EMBL:X04831) Escherichia coli mutator MutT protein (7%2C8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.*) MutT%2C 129 aa%3B fasta scores: opt: 190 Z-score: 228.6 bits: 48.1 E(): 4e-05%3B 33.333%25 identity in 132 aa overlap. Contains Pfam match to entry PF00293 mutT%2C MutT-like domain and match to Prosite entry PS00893 mutT domain signature gene gene5154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5102 SCO5103 SCO5103 SCBAC28G1.29 SCBAC28G1.29 5542948 5543415 + regulatory protein SCBAC28G1.29%2C possible regulatory protein%2C len: 155 aa%3B similar to TR:Q53897 (EMBL:X60316) Streptomyces coelicolor AbaA gene (regulator) or SCF42.12c%2C 192 aa%3B fasta scores: opt: 207 Z-score: 233.7 bits: 49.7 E(): 2.1e-05%3B 41.270%25 identity in 126 aa overlap. Contains Pfam match to entry PF02518 HATPase_c%2C Histidine kinase-%2C DNA gyrase B-%2C phytochrome-like ATPase gene gene5155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5103 SCO5104 SCO5104 SCBAC28G1.30 SCBAC28G1.30 5543715 5546357 + hypothetical protein SCBAC28G1.30%2C hypothetical protein%2C len: 880 aa%3B similar to many Streptomyces coelicolor hypothetical proteins%2C e.g. TR:Q9KYN1 (EMBL:AL356592) hypothetical 84.7 kDa protein SC9H11.08%2C 802 aa%3B fasta scores: opt: 1062 Z-score: 1155.9 bits: 224.9 E(): 9.1e-57%3B 38.902%25 identity in 856 aa overlap. Contains 2x Pfam matches%2C Pfam match to entry PF01590 GAF%2C GAF domain%2C to entry PF00989 PAS%2C PAS domain and to entry PF02518 HATPase_c%2C Histidine kinase-%2C DNA gyrase B-%2C phytochrome-like ATPase gene gene5156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5104 SCO5105 SCO5105 SCBAC31E11.01 SCBAC31E11.01 5546599 5547831 + hypothetical protein SCBAC31E11.01%2C possible membrane protein%2C len: 410 aa. Contains possible hydrophobic membrane spanning region gene gene5157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5105 SCO5106 SCO5106 SCBAC31E11.02c SCBAC31E11.02c 5547828 5548607 - fumarate reductase iron-sulfur subunit catalyzes the fumarate and succinate interconversion%3B fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source gene gene5158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5106 SCO5107 SCO5107 sdhA sdhA 5548604 5550565 - succinate dehydrogenase flavoprotein subunit part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers)%3B SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556%3B SdhC binds ubiquinone%3B oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol gene gene5159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5107 SCO5108 SCO5108 SCBAC31E11.04c SCBAC31E11.04c 5550582 5551418 - hypothetical protein SCBAC31E11.04c%2C possible integral membrane protein%2C len: 278 aa%3B similar to TR:O53671 (EMBL:AL021929) Mycobacterium tuberculosis hypothetical 31.1 kDa protein MTV034.15c%2C 273 aa%3B fasta scores: opt: 1010 Z-score: 1230.3 bits: 235.4 E(): 6.5e-61%3B 54.545%25 identity in 275 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5108 SCO5109 SCO5109 SCBAC31E11.05c SCBAC31E11.05c 5551480 5551920 - hypothetical protein SCBAC31E11.05c%2C unknown%2C len: 146 aa. Contains a possible coiled-coil region at approx. residues 60..87 gene gene5161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5109 SCO5110 SCO5110 SCBAC31E11.06 SCBAC31E11.06 5552093 5554408 + lipoprotein SCBAC31E11.06%2C possible lipoprotein%2C len: 771 aa%3B similar to SW:YC80_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical 63.5 kDa protein MTCY50.02%2C 591 aa%3B fasta scores: opt: 565 Z-score: 501.6 bits: 103.2 E(): 2.5e-20%3B 26.190%25 identity in 756 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene5162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5110 SCO5111 SCO5111 SCBAC31E11.07 SCBAC31E11.07 5554541 5556448 + GTP-binding protein SCBAC31E11.07%2C possible GTP-binding protein%2C len: 635 aa%3B similar to SW:TYPA_ECOLI (EMBL:L19201) Escherichia coli GTP-binding protein TypA/BipA (tyrosine phosphorylated protein A) TypA or BipA or B3871%2C 591 aa%3B fasta scores: opt: 915 Z-score: 968.6 bits: 189.3 E(): 2.5e-46%3B 48.039%25 identity in 612 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU%2C Elongation factor Tu family and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature gene gene5163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5111 SCO5112 SCO5112 bldKA bldKA 5557355 5558386 + ABC transporter integral membrane protein BldKA SCBAC31E11.08%2C bldKA%2C possible ABC transport system integral membrane protein%2C len: 343 aa%3B identical to previously sequenced TR:P72406 (EMBL:U68036) Streptomyces coelicolor BldKA%2C 335 aa. Methionine start codon 9 amino acids upstream from the previous sequence start%3B possible frameshift from frame 2 into frame 1 in the previously sequenced DNA. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene5164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5112 SCO5113 SCO5113 bldKB bldKB 5558498 5560300 + ABC transporter lipoprotein BldKB SCBAC31E11.09%2C bldKB%2C possible ABC transport system lipoprotein%2C len: 600 aa%3B almost identical to TR:P72407 (EMBL:U68036) Streptomyces coelicolor BldKB%2C 602 aa. Contains 4x Pfam matches to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5%2C match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene5165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5113 SCO5114 SCO5114 bldKC bldKC 5560414 5561391 + ABC transporter integral membrane protein BldKC SCBAC31E11.10%2C bldKC%2C possible ABC transport system integral membrane protein%2C len: 325 aa%3B almost identical to previously sequenced TR:P72408 (EMBL:U68036) Streptomyces coelicolor BldKC%2C 323 aa. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions gene gene5166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5114 SCO5115 SCO5115 bldKD bldKD 5561402 5562463 + ABC transporter intracellular ATPase subunit BldKD SCBAC31E11.11%2C bldKD%2C ABC transporter intracellular ATPase subunit%2C len: 353 aa%3B almost identical to previously sequenced TR:P72409 (EMBL:U680360) Streptomyces coelicolor BldKD ABC transporter intracellular ATPase subunit%2C 353 aa and similar to TR:O86574 (EMBL:AL031184) Streptomyces coelicolor SC2A11.13%2C 366 aa%3B fasta scores: opt: 1427 Z-score: 1344.1 bits: 257.3 E(): 3.8e-69%3B 60.340%25 identity in 353 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5115 SCO5116 SCO5116 bldKE bldKE 5562491 5563636 + peptide transport system ATP-binding subunit SC9E12.01%2C probable peptide transport system ATP-binding protein (fragment)%2C len: >142 aa%3B similar to SW:OPPF_ECOLI (EMBL:AE000223) Escherichia coli oligopeptide transport protein ATP-binding protein OppF%2C 334 aa%3B fasta scores: opt: 344 z-score: 423.0 E(): 4.3e-16%3B 56.5%25 identity in 92 aa overlap and to TR:O86575 (EMBL:AL031184) Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SC2A11.14%2C 496 aa%3B fasta scores: opt: 488 z-score: 576.6 E(): 1.7e-26%3B 56.6%25 identity in 136 aa overlap~SCBAC31E11.12%2C bldKE%2C ABC transporter intracellular ATPase subunit (fragment)%2C len: >272 aa%3B almost identical to previously sequenced TR:P72410 (EMBL:U68036) Streptomyces coelicolor ABC transporter intracellular ATPase subunit (fragment) BldKE%2C 284 aa and similar to N-terminal region of TR:O86575 (EMBL:AL031184) Streptomyces coelicolor SC2A11.14%2C 497 aa%3B fasta scores: opt: 1186 Z-score: 1170.6 bits: 225.2 E(): 1.7e-59%3B 63.603%25 identity in 272 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5116 SCO5117 SCO5117 SC9E12.02 SC9E12.02 5563836 5565470 + peptide transport system peptide-binding protein SC9E12.02%2C possible peptide transport system peptide-binding protein%2C len: 544 aa%3B similar to SW:OPPA_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide-binding protein OppA precursor%2C 545 aa%3B fasta scores: opt: 648 z-score: 642.6 E(): 2.5e-28%3B 26.1%25 identity in 552 aa overlap and to TR:P72407 (EMBL:U68036) Streptomyces coelicolor SpoOKA homologue BldKB%2C 602 aa%3B blastp scores: Score %3D 165 (58.1 bits)%2C Expect %3D 2.9e-10%2C Sum P(2) %3D 2.9e-10%3B Identities %3D 116/502 (23%25)%2C Positives %3D 202/502 (40%25). Contains 2x Pfam matches to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5 and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene5169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5117 SCO5118 SCO5118 SC9E12.03 SC9E12.03 5565480 5566403 + peptide transport system integral membrane protein SC9E12.03%2C probable peptide transport system integral membrane protein%2C len: 307 aa%3B similar to TR: SW:OPPB_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport system permease OppB%2C 311 aa%3B fasta scores: opt: 688 z-score: 788.7 E(): 0%3B 36.0%25 identity in 308 aa overlap and to TR:P72408 (EMBL:U68036) Streptomyces coelicolor SpoOKC homologue BldKC%2C 323 aa%3B blastp scores: Score %3D 354 (124.6 bits)%2C Expect %3D 1.9e-32%2C P %3D 1.9e-32%3B Identities %3D 82/235 (34%25)%2C Positives %3D 138/235 (58%25). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions gene gene5170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5118 SCO5119 SCO5119 SC9E12.04 SC9E12.04 5566459 5567376 + peptide transport system integral membrane protein SC9E12.04%2C probable peptide transport system integral membrane protein%2C len: 305 aa%3B similar to SW:OPPC_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport system permease OppC%2C 305 aa%3B fasta scores: opt: 670 z-score: 745.0 E(): 0%3B 35.5%25 identity in 296 aa overlap and to TR:P72406 (EMBL:U68036) Streptomyces coelicolor SpoOKB homologue BldKA%2C 335 aa%3B blastp scores: Score %3D 382 (134.5 bits)%2C Expect %3D 9.1e-41%2C Sum P(2) %3D 9.1e-41%3B Identities %3D 88/231 (38%25)%2C Positives %3D 134/231 (58%25). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and possible hydrophobic membrane spanning regions gene gene5171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5119 SCO5120 SCO5120 SC9E12.05 SC9E12.05 5567385 5568368 + peptide transport system ATP-binding protein SC9E12.05%2C probable peptide transport system ATP-binding protein%2C len: 327 aa%3B similar to SW:OPPD_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport system ATP-binding protein OppD%2C 358 aa%3B fasta scores: opt: 1126 z-score: 1167.7 E(): 0%3B 53.9%25 identity in 310 aa overlap%2C to TR:P72409 (EMBL:U68036) Streptomyces coelicolor ABC transporter intracellular ATPase subunit BldKD%2C 353 aa%3B fasta scores: opt: 1035 z-score: 1074.2 E(): 0%3B 51.5%25 identity in 326 aa overlap and to TR:O86574 (EMBL:AL031184) Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SC2A11.13%2C 365 aa%3B fasta scores: opt: 1097 z-score: 945.2 E(): 0%3B 52.3%25 identity in 331 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5120 SCO5121 SCO5121 SC9E12.06 SC9E12.06 5568361 5569431 + peptide transport system ATP-binding protein SC9E12.06%2C probable peptide transport system ATP-binding protein%2C len: 356 aa%3B similar to SW:APPF_BACSU (EMBL:U20909) Bacillus subtilis oligopeptide transport ATP-binding protein AppF%2C 329 aa%3B fasta scores: opt: 1255 z-score: 1332.6 E(): 0%3B 57.3%25 identity in 335 aa overlap%2C to TR:P72410 (EMBL:U68036) Streptomyces coelicolor ABC transporter intracellular ATPase subunit BldKE (fragment)%2C 284 aa%3B fasta scores: opt: 999 z-score: 1063.6 E(): 0%3B 58.1%25 identity in 260 aa overlap and to TR:O86575 (EMBL:AL031184) Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SC2A11.14%2C 496 aa%3B fasta scores: opt: 1306 z-score: 1117.3 E(): 0%3B 55.4%25 identity in 345 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5121 SCO5122 SCO5122 SC9E12.07c SC9E12.07c 5569564 5571687 - peptidase SC9E12.07c%2C probable peptidase%2C len: 707 aa%3B similar to TR:P95782 (EMBL:D83263) Xanthomonas maltophilia dipeptidyl peptidase IV%2C 741 aa%3B fasta scores: opt: 442 z-score: 478.1 E(): 3.7e-19%3B 33.2%25 identity in 733 aa overlap. Contains Pfam matches to entries PF00930 DPPIV_N_term%2C Dipeptidyl peptidase IV (DPP IV) N-terminal region and PF00326 Peptidase_S9%2C Prolyl oligopeptidase family and match to Prosite entry PS00708 Prolyl endopeptidase family serine active site gene gene5174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5122 SCO5123 SCO5123 SC9E12.08 SC9E12.08 5571874 5572068 + small membrane protein SC9E12.08%2C possible small membrane protein%2C len: 64 aa%3B similar to TR:Q9RKX4 (EMBL:AL133213) Streptomyces coelicolor hypothetical protein SC6D7.24c%2C 64 aa%3B fasta scores: opt: 225 z-score: 329.1 E(): 7.3e-11%3B 56.5%25 identity in 62 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5123 SCO5124 SCO5124 SC9E12.09c SC9E12.09c 5572058 5572264 - hypothetical protein SC9E12.09c%2C hypothetical protein%2C len: 68 aa%3B similar to TR:Q9RDR5 (EMBL:AL136500) Streptomyces coelicolor hypothetical 7.7 kDa protein SC1G2.14c%2C 73 aa%3B fasta scores: opt: 217 z-score: 327.7 E(): 8.7e-11%3B 55.9%25 identity in 59 aa overlap gene gene5176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5124 SCO5125 SCO5125 SC9E12.10c SC9E12.10c 5572261 5573124 - hypothetical protein SC9E12.10c%2C hypothetical protein%2C len: 287 aa%3B similar to TR:Q9RDR4 (EMBL:AL136500) Streptomyces coelicolor hypothetical 31.7 kDa protein SC1G2.15c%2C 284 aa%3B fasta scores: opt: 1240 z-score: 1466.1 E(): 0%3B 67.2%25 identity in 287 aa overlap gene gene5177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5125 SCO5126 SCO5126 SC9E12.11 SC9E12.11 5573276 5574163 + hypothetical protein SC9E12.11%2C hypothetical protein%2C len: 295 aa%3B similar to TR:O50426 (EMBL:AL010186) Mycobacterium tuberculosis hypothetical 31.7 kDa protein MTV005.06%2C 303 aa%3B fasta scores: opt: 531 z-score: 607.8 E(): 2.2e-26%3B 44.4%25 identity in 306 aa overlap gene gene5178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5126 SCO5127 SCO5127 SC9E12.12 SC9E12.12 5574160 5574582 + hypothetical protein SC9E12.12%2C possible integral membrane protein%2C len: 1450 aa. Contains possible hydrophobic membrane spanning regions gene gene5179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5127 SCO5128 SCO5128 SC9E12.13 SC9E12.13 5574738 5577065 + hypothetical protein SC9E12.13%2C possible membrane protein%2C len: 775 aa%3B highly hydrophilic. Contains possible hydrophobic membrane spanning region gene gene5180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5128 SCO5129 SCO5129 SC9E12.14 SC9E12.14 5577212 5578168 + ABC transporter ATP-binding protein SC9E12.14%2C possible ABC transporter ATP-binding protein%2C len: 318 aa%3B similar to TR:CAB88183 (EMBL:AL352972) Streptomyces coelicolor ABC transporter ATP-binding protein SCC30.13%2C 308 aa%3B fasta scores: opt: 861 z-score: 926.3 E(): 0%3B 54.4%25 identity in 309 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5129 SCO5130 SCO5130 SC9E12.15 SC9E12.15 5578165 5578905 + ABC transporter SC9E12.15%2C possible ABC transporter integral membrane protein%2C len: 246 aa%3B similar to TR:CAB88184 (EMBL:AL352972) Streptomyces coelicolor ABC transporter integral membrane protein SCC30.14%2C 238 aa%3B fasta scores: opt: 516 z-score: 611.2 E(): 1.4e-26%3B 35.9%25 identity in 237 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5130 SCO5131 SCO5131 SC9E12.16 SC9E12.16 5578902 5580068 + two-component system sensor kinase SC9E12.16%2C possible two-component system sensor kinase%2C len: 388 aa%3B similar to TR:CAB88185 (EMBL:AL352972) Streptomyces coelicolor two-component system sensor kinase SCC30.15%2C 409 aa%3B fasta scores: opt: 773 z-score: 840.8 E(): 0%3B 41.9%25 identity in 389 aa overlap. Contains possible hydrophobic membrane spanning regions at N-terminal domain gene gene5183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5131 SCO5132 SCO5132 SC9E12.17 SC9E12.17 5580065 5580679 + two-component system response regulator SC9E12.17%2C possible two-component system response regulator%2C len: 204 aa%3B similar to TR:CAB88186 (EMBL:AL352972) Streptomyces coelicolor two-component response regulator SCC30.16%2C 210 aa%3B fasta scores: opt: 822 z-score: 928.1 E(): 0%3B 63.0%25 identity in 200 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. Also contains possible helix-turn-helix motif at residues 159..180 (+5.28 SD) gene gene5184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5132 SCO5133 SCO5133 SC9E12.18c SC9E12.18c 5580789 5581685 - hypothetical protein SC9E12.18c%2C hypothetical protein%2C len: 298 aa%3B C-terminal highly similar to N-terminal domain of TR:Q07641 (EMBL:AB006206) Streptomyces griseus hypothetical 34.5 kDa protein in AmfR 3'region (fragment)%2C 87 aa%3B fasta scores: opt: 371 z-score: 414.3 E(): 1.3e-15%3B 63.2%25 identity in 87 aa overlap gene gene5185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5133 SCO5134 SCO5134 SC9E12.19c SC9E12.19c 5581727 5582761 - hypothetical protein SC9E12.19c%2C hypothetical protein%2C len: 344 aa%3B highly similar to TR:O87087 (EMBL:AB006206) Streptomyces griseus AmfR%2C AmfA and AmfB genes and 4 ORFS%2C complete CDS%2C ORF5%2C 264 aa%3B fasta scores: opt: 1018 z-score: 1086.7 E(): 0%3B 63.3%25 identity in 264 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene5186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5134 SCO5135 SCO5135 fdxA1 fdxA1 5582902 5583222 + ferredoxin SC9E12.20%2C fdxA1%2C ferredoxin%2C len: 106 aa%3B similar to SW:FER_SACER (EMBL:M61119) Saccharopolyspora erythraea ferredoxin FdxA%2C 105 aa%3B fasta scores: opt: 618 z-score: 759.8 E(): 0%3B 78.1%25 identity in 105 aa overlap and to TR:CAC04216 (EMBL:AL391515) Streptomyces coelicolor FdxA%2C ferredoxin%2C 129 aa%3B fasta scores: opt: 520 z-score: 702.1 E(): 1.8e-33%3B 65.7%25 identity in 105 aa overlap. Contains Pfam match to entry PF00037 fer4%2C 4Fe-4S binding domain and match to Prosite entry PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene5187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5135 SCO5136 SCO5136 SC9E12.21 SC9E12.21 5583339 5584436 + N-succinyldiaminopimelate aminotransferase catalyzes the formation of N-succinyl-LL-2%2C6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis gene gene5188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5136 SCO5137 SCO5137 SC9E12.22c SC9E12.22c 5584655 5585086 - ATP-binding protein SC9E12.22c%2C possible ATP-binding protein%2C len: 143 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible hydrophobic membrane spanning region gene gene5189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5137 SCO5138 SCO5138 SC9E12.23c SC9E12.23c 5585424 5586392 - hypothetical protein SCP8.01c%2C possible membrane protein (fragment)%2C len: >86 aa. . Contains possible hydrophobic membrane spanning region~SC9E12.23c%2C hypothetical protein (fragment)%2C len: >270 aa%3B similar to TR:Q9X867 (EMBL:AL049661) Streptomyces coelicolor lipoprotein SCE134.12%2C 381 aa%3B fasta scores: opt: 432 z-score: 481.0 E(): 2.5e-19%3B 41.2%25 identity in 211 aa overlap gene gene5190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5138 SCO5139 SCO5139 dapE dapE 5586476 5587555 + succinyl-diaminopimelate desuccinylase catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate gene gene5191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5139 SCO5140 SCO5140 SCP8.03 SCP8.03 5587673 5588431 + hypothetical protein SCP8.03%2C hypothetical protein%2C len: 252 aa%3B similar to TR:Q46063 (EMBL:X81379) Corynebacterium glutamicum ORF2%2C 211 aa%3B fasta scores: opt: 938 z-score: 1070.3 E(): 0%3B 67.1%25 identity in 210 aa overlap gene gene5192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5140 SCO5141 SCO5141 folP folP 5588682 5589566 - dihydropteroate synthase SCP8.04c%2C folP%2C dihydropteroate synthase%2C len: 294 aa%3B similar to SW:DHPS_MYCLE (EMBL:U15180) Mycobacterium leprae dihydropteroate synthase (EC 2.5.1.15) (DHPS) FolP%2C 291 aa%3B fasta scores: opt: 1095 z-score: 1239.8 E(): 0%3B 60.6%25 identity in 292 aa overlap. Contains Pfam match to entry PF00809 DHPS%2C Dihydropteroate synthase and matches to Prosite entries PS00792 Dihydropteroate synthase signature 1 and PS00793 Dihydropteroate synthase signature 2 gene gene5193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5141 SCO5142 SCO5142 SCP8.05 SCP8.05 5589711 5590070 + hypothetical protein SCP8.05%2C possible hypothetical protein%2C len: 119 aa. Contains possible coiled-coil region at approx residues 77..95 and N-terminal region signal peptide sequence gene gene5194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5142 SCO5143 SCO5143 SCP8.06 SCP8.06 5590067 5590651 + DNA-3-methyladenine glycosylase I SCP8.06%2C tag%2C DNA-3-methyladenine glycosylase I%2C len: 194 aa%3B highly similar to SW:3MG1_ECOLI (EMBL:J02606) Escherichia coli DNA-3-methyladenine glycosylase I (EC 3.2.2.20) Tag%2C 187 aa%3B fasta scores: opt: 529 z-score: 636.5 E(): 5.5e-28%3B 45.2%25 identity in 177 aa overlap gene gene5195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5143 SCO5144 SCO5144 SCP8.07c SCP8.07c 5591303 5592106 - acyl CoA isomerase SCP8.07c%2C probable acyl CoA isomerase%2C len: 267 aa%3B highly similar to TR:AAF73478 (EMBL:AF268489) Streptomyces collinus 2-cyclohexenylcarbonyl CoA isomerase ChcB%2C 269 aa%3B fasta scores: opt: 1476 z-score: 1623.5 E(): 0%3B 87.6%25 identity in 266 aa overlap and to SW:CRT_CLOAB (EMBL:U17110) Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Crt%2C 261 aa%3B fasta scores: opt: 426 z-score: 476.6 E(): 4.4e-19%3B 32.4%25 identity in 259 aa overlap. Contains Pfam match to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family and match to Prosite entry PS00166 Enoyl-CoA hydratase/isomerase signature gene gene5196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5144 SCO5145 SCO5145 SCP8.08 SCP8.08 5592410 5592634 + hypothetical protein SCP8.08%2C conserved hypothetical protein%2C len: 74 aa%3B highly similar to TR:O05312 (EMBL:Z93777) Mycobacterium tuberculosis hypothetical 7.8 kD protein MTCI364.23%2C 75 aa%3B fasta scores: opt: 323 z-score: 419.6 E(): 6.6e-16%3B 78.6%25 identity in 70 aa overlap gene gene5197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5145 SCO5146 SCO5146 SCP8.09c SCP8.09c 5592745 5593269 - methyltransferase SCP8.09c%2C probable methyltransferase%2C len: 174 aa%3B similar to SW:MDMC_STRMY (EMBL:M93958) Streptomyces mycarofaciens O-methyltransferase (EC 2.1.1.-) MdmC%2C 221 aa%3B fasta scores: opt: 253 z-score: 313.8 E(): 5.2e-10%3B 31.5%25 identity in 178 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3%2C O-methyltransferase gene gene5198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5146 SCO5147 SCO5147 SCP8.10 SCP8.10 5593690 5594361 + RNA polymerase sigma factor SigE Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B in M. tuberculosis this protein is involved in heat shock%2C oxidative stress and virulence gene gene5199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5147 SCO5148 SCO5148 SCP8.11 SCP8.11 5594358 5595347 + hypothetical protein SCP8.11%2C possible membrane protein%2C len: 329 aa. Contains possible hydrophobic membrane spanning region gene gene5200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5148 SCO5149 SCO5149 SCP8.12 SCP8.12 5595838 5597466 + protease SCP8.12%2C possible protease%2C len: 542 aa%3B C-terminal region similar to TR:O53896 (EMBL:AL021999) Mycobacterium tuberculosis serine protease MTV044.11%2C 464 aa%3B fasta scores: opt: 803 z-score: 614.5 E(): 9.2e-27%3B 39.4%25 identity in 469 aa overlap and to TR:AAF61294 (EMBL:AF155705) Lactococcus lactis serine protease HtrA%2C 408 aa%3B fasta scores: opt: 536 z-score: 415.8 E(): 1.1e-15%3B 34.8%25 identity in 310 aa overlap. Contains Pfam matches to entries PF00089 trypsin%2C Trypsin and PF00595 PDZ%2C PDZ domain (Also known as DHR or GLGF) gene gene5201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5149 SCO5150 SCO5150 SCP8.13 SCP8.13 5597613 5598098 + sec-independent translocase mediates the export of protein precursors bearing twin-arginine signal peptides gene gene5202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5150 SCO5151 SCO5151 SCP8.14 SCP8.14 5598255 5599001 + hypothetical protein SCP8.14%2C unknown%2C len: 248 aa gene gene5203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5151 SCO5152 SCO5152 SCP8.15c SCP8.15c 5599076 5600209 - ATP-binding protein SCP8.15c%2C probable ATP-binding protein%2C len: 371 aa%3B similar to SW:MRP_MYCTU (EMBL:Z98260) Mycobacterium tuberculosis Mrp protein homolog MTV006.01c%2C 390 aa%3B fasta scores: opt: 1650 z-score: 1730.0 E(): 0%3B 67.9%25 identity in 371 aa overlap and to SW:MRP_ECOLI (EMBL:U00007) Escherichia coli Mrp protein%2C 379 aa%3B fasta scores: opt: 706 z-score: 744.5 E(): 0%3B 35.8%25 identity in 363 aa overlap. Contains Pfam matches to entries PF01883 DUF59%2C Domain of unknown function DUF59 and PF00142 fer4_NifH%2C 4Fe-4S iron sulfur cluster binding proteins%2C NifH/frxC family and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS01215 Mrp family signature gene gene5204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5152 SCO5153 SCO5153 SCP8.16c SCP8.16c 5600254 5600850 - hypothetical protein SCP8.16c%2C possible integral membrane protein%2C len: 198 aa%3B similar to TR:O86314 (EMBL:Z98260) Mycobacterium tuberculosis hypothetical 20.4 kD protein MTV006.03c%2C 180 aa%3B fasta scores: opt: 517 z-score: 619.2 E(): 5.1e-27%3B 52.9%25 identity in 157 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5153 SCO5154 SCO5154 SCP8.17c SCP8.17c 5600843 5602144 - hypothetical protein SCP8.17c%2C hypothetical protein%2C len: 433 aa%3B highly similar to TR:O86315 (EMBL:Z98260) Mycobacterium tuberculosis hypothetical 47.4 kD protein MTV006.04c%2C 435 aa%3B fasta scores: opt: 1335 z-score: 1494.5 E(): 0%3B 49.9%25 identity in 425 aa overlap and C-terminal region similar to C-terminal region of TR:Q9X0P4 (EMBL:AE001773) Thermotoga maritima Mg2+ transporter MgtE%2C %2C 446 aa%3B fasta scores: opt: 390 z-score: 439.1 E(): 5.4e-17%3B 31.3%25 identity in 240 aa overlap gene gene5206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5154 SCO5155 SCO5155 SCP8.18 SCP8.18 5602439 5603170 + lipoprotein SCP8.18%2C possible lipoprotein%2C len: 243 aa%3B similar to TR:CAB76294 (EMBL:AL158057) Streptomyces coelicolor lipoprotein SC1G8.21c%2C 249 aa%3B fasta scores: opt: 238 z-score: 275.6 E(): 7e-08%3B 29.3%25 identity in 249 aa overlap. Contains possible N-terminal region signal peptide sequence and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5155 SCO5156 SCO5156 SCP8.19c SCP8.19c 5603185 5603697 - hypothetical protein SCP8.19c%2C unknown%2C len: 170 aa gene gene5208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5156 SCO5157 SCO5157 SCP8.20c SCP8.20c 5603731 5604846 - metal-transport protein SCP8.20c%2C probable metal-transport protein%2C len: 371 aa%3B similar to TR:O50455 (EMBL:AL021006) Mycobacterium tuberculosis magnesium and cobalt transport protein MTV006.11c%2C 366 aa%3B fasta scores: opt: 1137 z-score: 1293.8 E(): 0%3B 47.8%25 identity in 370 aa overlap and to SW:CORA_ECOLI (EMBL:L11042) Escherichia coli magnesium and cobalt transport protein CorA%2C 316 aa%3B fasta scores: opt: 211 z-score: 245.7 E(): 3.2e-06%3B 23.2%25 identity in 306 aa overlap. Contains Pfam match to entry PF01544 CorA%2C CorA-like Mg2+ transporter and possible hydrophobic membrane spanning region at C-terminal domain gene gene5209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5157 SCO5158 SCO5158 SCP8.21 SCP8.21 5605370 5605966 + hypothetical protein SCP8.21%2C unknown%2C len: 198 aa gene gene5210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5158 SCO5159 SCO5159 SCP8.22c SCP8.22c 5606015 5607238 - integral membrane transport protein SCP8.22c%2C possible integral membrane transport protein%2C len: 407 aa%3B similar to TR:CAB76344 (EMBL:AL158061) Streptomyces coelicolor multidrug-efflux transporter SC6D11.21%2C 577 aa%3B fasta scores: opt: 1286 z-score: 1436.2 E(): 0%3B 51.1%25 identity in 393 aa overlap and to SW:BMR1_BACSU (EMBL:M33768) Bacillus subtilis multidrug resistance protein 1 Bmr1%2C 389 aa%3B fasta scores: opt: 262 z-score: 298.0 E(): 3.9e-09%3B 22.9%25 identity in 375 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and possible hydrophobic membrane spanning regions gene gene5211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5159 SCO5160 SCO5160 SCP8.23 SCP8.23 5607430 5608080 + hypothetical protein SCP8.23%2C unknown%2C len: 216 aa gene gene5212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5160 SCO5161 SCO5161 SCP8.24 SCP8.24 5608309 5609166 + hypothetical protein SCP8.24%2C hypothetical protein%2C len: 285 aa%3B similar to SW:TRPH_ECOLI (EMBL:AE000224) Escherichia coli TrpH protein%2C 293 aa%3B fasta scores: opt: 376 z-score: 429.3 E(): 1.9e-16%3B 30.6%25 identity in 248 aa overlap. Contains Pfam match to entry PF02231 PHP_N%2C PHP domain N-terminal region gene gene5213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5161 SCO5162 SCO5162 SCP8.25 SCP8.25 5609220 5609825 + hypothetical protein SCP8.25%2C possible integral membrane protein%2C len: 201 aa%3B similar to SW:YCHE_ECOLI (EMBL:AE000222) Escherichia coli hypothetical 23.5 kD protein in AdhE-OppA intergenic region YchE%2C 215 aa%3B fasta scores: opt: 406 z-score: 496.2 E(): 3.6e-20%3B 30.0%25 identity in 207 aa overlap. Contains Pfam match to entry PF01914 UPF0056%2C Uncharacterized protein family UPF0056 and possible hydrophobic membrane spanning regions gene gene5214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5162 SCO5163 SCO5163 SCP8.26c SCP8.26c 5609892 5610044 - hypothetical protein SCP8.26c%2C unknown%2C len: 50 aa. Highly hydrophilic gene gene5215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5163 SCO5164 SCO5164 SCP8.27 SCP8.27 5610280 5611185 + hypothetical protein SCP8.27%2C hypothetical protein%2C len: 300 aa%3B similar to N-terminal region of TR:Q9S2S7 (EMBL:AL096884) Streptomyces coelicolor hypothetical 44.0 kD protein SC4G6.31c%2C 403 aa%3B fasta scores: opt: 423 z-score: 494.8 E(): 4.3e-20%3B 36.5%25 identity in 230 aa overlap gene gene5216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5164 SCO5165 SCO5165 SCP8.28c SCP8.28c 5611293 5612189 - hydrolase SCP8.28c%2C possible hydrolase%2C len: 298 aa%3B similar to TR:Q9RL59 (EMBL:AL121596) Streptomyces coelicolor hydrolase SCF51A.05%2C 278 aa%3B fasta scores: opt: 217 z-score: 249.2 E(): 2e-06%3B 27.0%25 identity in 267 aa overlap and to SW:THCF_RHOER (EMBL:U95170) Rhodococcus erythropolis non-heme haloperoxidase (EC 1.11.1.-) ThcF%2C 274 aa%3B fasta scores: opt: 185 z-score: 213.7 E(): 0.00019l%3B 29.0%25 identity in 241 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and match to Prosite entry PS00120 Lipases%2C serine active site gene gene5217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5165 SCO5166 SCO5166 SCP8.29c SCP8.29c 5612300 5614939 - helicase SCP8.29c%2C possible helicase%2C len: 879 aa%3B N-terminal domain similar to SW:RHLE_ECOLI (EMBL:L02123) Escherichia coli ATP-dependent RNA helicase RhlE%2C 454 aa%3B fasta scores: opt: 884 z-score: 704.8 E(): 8.6e-32%3B 37.2%25 identity in 444 aa overlap. Contains Pfam matches to entries PF00270 DEAD%2C DEAD/DEAH box helicase and PF00271 helicase_C%2C Helicases conserved C-terminal domain and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00039 DEAD-box subfamily ATP-dependent helicases signature. Also contains three sets of different repeats: 10x RU1: RRTRK%2C 4x RU2:AAAKAEAAA and 4x RU3:AAEPA gene gene5218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5166 SCO5167 SCO5167 SCP8.30 SCP8.30 5615432 5616214 + hypothetical protein SCP8.30%2C conserved hypothetical protein%2C len: 260 aa%3B similar to TR:O05856 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 25.1 kD protein MTCY07D11.16%2C 231 aa%3B fasta scores: opt: 599 z-score: 647.2 E(): 1.4e-28%3B 42.5%25 identity in 233 aa overlap. Contains 4x degenerate repeat:T(G/A)G gene gene5219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5167 SCO5168 SCO5168 SCP8.31c SCP8.31c 5616330 5616599 - hypothetical protein SCP8.31c%2C possible integral membrane protein%2C len: 89 aa. Contains possible hydrophobic membrane spanning regions. Also high content in alanine and leucine amino acid residues gene gene5220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5168 SCO5169 SCO5169 SCP8.32c SCP8.32c 5616843 5617127 - ATP-binding protein SCP8.32c%2C possible ATP-binding protein%2C len: 94 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5169 SCO5170 SCO5170 SCP8.33c SCP8.33c 5617213 5617854 - TetR family transcriptional regulator SCP8.33c%2C probable tetR-family transcriptional regulator%2C len: 213 aa%3B similar to TR:O53661 (EMBL:AL021929) Mycobacterium tuberculosis regulatory protein MTV034.04%2C 204 aa%3B fasta scores: opt: 309 z-score: 383.4 E(): 6.9e-14%3B 31.3%25 identity in 201 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 42..63 (+3.37 SD) gene gene5222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5170 SCO5171 SCO5171 SCP8.34c SCP8.34c 5618029 5618256 - hypothetical protein SCP8.34c%2C unknown%2C len: 75 aa. Highly hydrophilic gene gene5223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5171 SCO5172 SCO5172 SCP8.35 SCP8.35 5618484 5619560 + hydrolase SCP8.35%2C possible hydrolase%2C len: 358 aa%3B similar to SW:ACOC_ALCEU (EMBL:M66060) Alcaligenes eutrophus dihydrolipoamide acetyltransferase component of acetoin cleaving system (EC 2.3.1.12) AcoC%2C 373 aa%3B fasta scores: opt: 224 z-score: 254.0 E(): 1.1e-06%3B 29.7%25 identity in 273 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene5224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5172 SCO5173 SCO5173 SCP8.36 SCP8.36 5619569 5621248 + hypothetical protein SCP8.36%2C hypothetical protein%2C len: 559 aa%3B low similarity to TR:Q9XAG2 (EMBL:AL079356) Streptomyces coelicolor possible membrane protein SC6G9.20%2C 303 aa%3B fasta scores: opt: 452 z-score: 362.9 E(): 9.5e-13%3B 34.1%25 identity in 258 aa overlap gene gene5225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5173 SCO5174 SCO5174 SCP8.37 SCP8.37 5621463 5623244 + transferase SCP8.37%2C possible transferase%2C len: 593 aa%3B C-terminal region similar to TR:CAB92272 (EMBL:AL356595) Streptomyces coelicolor transferase SCC61A.27%2C 436 aa%3B fasta scores: opt: 233 z-score: 251.3 E(): 1.6e-06%3B 29.9%25 identity in 462 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1. Also contains 3x conserved repeat unit: ARSSE gene gene5226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5174 SCO5175 SCO5175 SCP8.38 SCP8.38 5623391 5624458 + hypothetical protein SCP8.38%2C possible integral membrane protein%2C len: 355 aa%3B similar to TR:Q9RWF6 (EMBL:AE001927) Deinococcus radiodurans hypothetical 51.5 kD protein DR0712%2C 494 aa%3B fasta scores: opt: 182 z-score: 183.8 E(): 0.009%3B 30.3%25 identity in 429 aa overlap gene gene5227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5175 SCO5176 SCO5176 SCP8.39 SCP8.39 5624510 5625622 + reductase SCP8.39%2C probable reductase%2C len: 370 aa%3B similar to TR:O54256 (EMBL:AJ224512) Streptomyces nogalater dTDP-4-keto-6-deoxyhexose reductase SnoG%2C 328 aa%3B fasta scores: opt: 316 z-score: 337.4 E(): 2.5e-11%3B 30.5%25 identity in 364 aa overlap gene gene5228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5176 SCO5177 SCO5177 2SC3B6.01 2SC3B6.01 5625610 5626359 + hypothetical protein 2SC3B6.01%2C unknown%2C len: 249 aa gene gene5229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5177 SCO5178 SCO5178 2SC3B6.02 2SC3B6.02 5626423 5627601 + adenylyltransferase/sulfurtransferase MoeZ The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin%2C but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2%2C6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation gene gene5230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5178 SCO5179 SCO5179 2SC3B6.03c 2SC3B6.03c 5627673 5629214 - peptidase 2SC3B6.03c%2C peptidase%2C len: 513 aa%3B identical to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE%2C 513 aa and highly similar to Streptomyces coelicolor 2SC3B6.04c%2C 516 aa%3B fasta scores: opt: 1544 z-score: 1384.8 E(): 0%3B 50.2%25 identity in 526 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene5231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5179 SCO5180 SCO5180 2SC3B6.04c 2SC3B6.04c 5629373 5630923 - peptidase 2SC3B6.04c%2C peptidase%2C len: 516 aa%3B highly similar to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE%2C 513 aa%3B fasta scores: opt: 1543 z-score: 1741.5 E(): 0%3B 50.2%25 identity in 526 aa overlap and to Streptomyces coelicolor peptidase 2SC3B6.03c%2C 513 aa%3B fasta scores: opt: 1544 z-score: 1465.5 E(): 0%3B 50.2%25 identity in 526 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene5232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5180 SCO5181 SCO5181 2SC3B6.05c 2SC3B6.05c 5631004 5633781 - hypothetical protein 2SC3B6.05c%2C possible integral membrane protein%2C len: 925 aa%3B similar to TR:O53781 (EMBL:AL021942) Mycobacterium tuberculosis hypothetical 84.0 kD protein RV0585c%2C 795 aa%3B fasta scores: opt: 618 z-score: 636.0 E(): 5.9e-28%3B 28.1%25 identity in 884 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5181 SCO5182 SCO5182 2SC3B6.06 2SC3B6.06 5633823 5634374 + hypothetical protein 2SC3B6.06%2C conserved hypothetical protein%2C len: 183 aa%3B similar to TR:Q9RX87 (EMBL:AE001902) Deinococcus radiodurans conserved hypothetical protein DR0428%2C 139 aa%3B fasta scores: opt: 187 z-score: 230.6 E(): 2.2e-05%3B 35.2%25 identity in 122 aa overlap gene gene5234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5182 SCO5183 SCO5183 2SC3B6.07 2SC3B6.07 5634641 5638120 + ATP-dependent DNA helicase 2SC3B6.07%2C possible ATP-dependent DNA helicase%2C len: 1159 aa%3B similar to TR:O53347 (EMBL:AL021646) Mycobacterium tuberculosis ATP-dependent DNA helicase%2C MTV014.45c%2C 1101 aa%3B fasta scores: opt: 349 z-score: 368.0 E(): 5e-13%3B 29.2%25 identity in 1144 aa overlap to SW:UVRD_ECOLI (EMBL:M87049) Escherichia coli DNA helicase II (EC 3.6.1.-) UvrD%2C 720 aa%3B fasta scores: opt: 241 z-score: 255.5 E(): 9.2e-07%3B 26.3%25 identity in 800 aa overlap and to Streptomyces coelicolor 2SC3B6.08%2C 1222 aa%3B fasta scores: opt: 406 z-score: 336.0 E(): 4.2e-13%3B30.4%25 identity in 977 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase%2C UvrD/REP helicase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains 5x conserved repeat unit: ADAD gene gene5235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5183 SCO5184 SCO5184 2SC3B6.08 2SC3B6.08 5638145 5641813 + ATP-dependent DNA helicase 2SC3B6.08%2C possible ATP-dependent DNA helicase%2C len: 1222 aa%3B similar to TR::O53347 (EMBL:AL021646) Mycobacterium tuberculosis ATP-dependent DNA helicase%2C MTV014.45c%2C 1101 aa%3B fasta scores: opt: 1209 z-score: 1062.9 E(): 0%3B 38.4%25 identity in 1199 aa overlap to SW:HELD_ECOLI (EMBL:J04726) Escherichia coli helicase IV (EC 3.6.1.-) HelD%2C 648 aa%3B fasta scores: opt: 216 z-score: 194.6 E(): 0.0023%3B 25.3%25 identity in 471 aa overlap and to Streptomyces coelicolor 2SC3B6.07%2C 1159 aa%3B fasta scores: opt: 406 z-score: 293.0 E(): 1e-10%3B 30.2%25 identity in 977 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase%2C UvrD/REP helicase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5184 SCO5185 SCO5185 2SC3B6.09 2SC3B6.09 5641824 5643236 + peptidase 2SC3B6.09%2C possible peptidase%2C len: 470 aa%3B similar to TR:AAF73713 (EMBL:AE002246) Chlamydophila pneumoniae AR39 peptidase%2C M20/M25/M40 family CP0876%2C 439 aa%3B fasta scores: opt: 809 z-score: 938.0 E(): 0%3B 33.6%25 identity in 455 aa overlap. Contains Pfam match to entry PF01546 Peptidase_M20%2C Peptidase family M20/M25/M40 gene gene5237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5185 SCO5186 SCO5186 2SC3B6.10 2SC3B6.10 5643386 5644342 + hypothetical protein 2SC3B6.10%2C conserved hypothetical protein%2C len: 318 aa%3B similar to TR:O53345 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 33.8 kD protein MTV014.43c%2C 313 aa%3B fasta scores: opt: 334 z-score: 389.2 E(): 3.3e-14%3B 33.3%25 identity in 318 aa overlap gene gene5238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5186 SCO5187 SCO5187 2SC3B6.11c 2SC3B6.11c 5644429 5644671 - glutaredoxin-like protein 2SC3B6.11c%2C possible glutaredoxin-like protein%2C len: 80 aa%3B similar to SW:NRDH_LACLC (EMBL:X92690) Lactococcus lactis glutaredoxin-like protein NrdH%2C 72 aa%3B fasta scores: opt: 119 z-score: 176.0 E(): 0.024%3B 35.6%25 identity in 59 aa overlap. Contains match to Prosite entry PS00194 Thioredoxin family active site gene gene5239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5187 SCO5188 SCO5188 2SC3B6.12 2SC3B6.12 5644716 5647073 + ATP-dependent DNA helicase 2SC3B6.12%2C probable ATP-dependent DNA helicase%2C len: 785 aa%3B similar to SW:UVRD_ECOLI (EMBL:M87049) Escherichia coli DNA helicase II (EC 3.6.1.-) UvrD%2C 720 aa%3B fasta scores: opt: 649 z-score: 632.5 E(): 9.2e-28%3B 31.6%25 identity in 643 aa overlap. Contains 2x Pfam matches to entry PF00580 UvrD-helicase%2C UvrD/REP helicase%2C Pfam match to entry PF00570 HRDC%2C HRDC domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5188 SCO5189 SCO5189 2SC3B6.13 2SC3B6.13 5647169 5647570 + hypothetical protein 2SC3B6.13%2C unknown%2C len: 133 aa gene gene5241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5189 SCO5190 SCO5190 2SC3B6.14 2SC3B6.14 5647747 5648115 + DNA-binding protein 2SC3B6.14%2C possible DNA-binding protein%2C len: 122 aa%3B similar to TR:Q9X952 (EMBL:AJ239087) Streptomyces coelicolor hypothetical 9.7 kD protein WblE%2C 85 aa%3B fasta scores: opt: 183 z-score: 243.0 E(): 4.6e-06%3B 40.5%25 identity in 74 aa overlap and to TR:Q9S426 (EMBL:AF164439) Mycobacterium smegmatis WhmD%2C 129 aa%3B fasta scores: opt: 161 z-score: 213.2 E(): 0.00021%3B 29.0%25 identity in 93 aa overlap. Contains Pfam match to entry PF02178 AT_hook%2C DNA binding domain with preference for A/T rich regions and match to Prosite entry PS00354 HMG-I and HMG-Y DNA-binding domain (A+T-hook) gene gene5242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5190 SCO5191 SCO5191 2SC3B6.15 2SC3B6.15 5648112 5648435 + hypothetical protein 2SC3B6.15%2C unknown%2C len: 107 aa gene gene5243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5191 SCO5192 SCO5192 2SC3B6.16c 2SC3B6.16c 5648569 5649978 - hypothetical protein 2SC3B6.16c%2C hypothetical protein%2C len: 469 aa%3B similar to TR:O53343 (EMBL:AL021646) Mycobacterium tuberculosis ABC-transporter ATP binding protein MTV014.41%2C 447 aa%3B fasta scores: opt: 1156 z-score: 1301.9 E(): 0%3B 45.3%25 identity in 393 aa overlap gene gene5244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5192 SCO5193 SCO5193 2SC3B6.17c 2SC3B6.17c 5649971 5651299 - hypothetical protein 2SC3B6.17c%2C possible hypothetical protein%2C len: 442 aa%3B similar to TR:O53342 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 31.6 kD protein MTV014.40%2C 299 aa%3B fasta scores: opt: 233 z-score: 233.2 E(): 1.6e-05%3B 29.9%25 identity in 261 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene5245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5193 SCO5194 SCO5194 2SC3B6.18 2SC3B6.18 5651506 5652012 + hypothetical protein 2SC3B6.18%2C hypothetical protein%2C len: 168 aa%3B similar to TR:CAB72040 (EMBL:AJ391262) Neisseria meningitidis hypothetical 26.6 kD protein RNI5%2C 230 aa%3B fasta scores: opt: 249 z-score: 315.5 E(): 4.2e-10%3B 41.7%25 identity in 103 aa overlap gene gene5246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5194 SCO5195 SCO5195 2SC3B6.19 2SC3B6.19 5652152 5653906 + hypothetical protein 2SC3B6.19%2C hypothetical protein%2C len: 584 aa%3B N-terminal region similar to N-terminal region of TR:Q9RSA4 (EMBL:AE002055) Deinococcus radiodurans tellurium resistance protein TerA DR2223%2C 400 aa%3B fasta scores: opt: 552 z-score: 357.3 E(): 1.9e-12%3B 40.6%25 identity in 239 aa overlap and C-terminal region similar to TR:Q9RWP1 (EMBL:AE001920) Deinococcus radiodurans conserved hypothetical protein DR0625%2C 254 aa%3B blastp scores: Score %3D 262 (92.2 bits)%2C Expect %3D 7.4e-22%2C P %3D 7.4e-22%2C Identities %3D 68/208 (32%25)%2C Positives %3D 117/208 (56%25) gene gene5247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5195 SCO5196 SCO5196 2SC3B6.20 2SC3B6.20 5653920 5654600 + hypothetical protein 2SC3B6.20%2C conserved hypothetical protein%2C len: 226 aa%3B similar to TR:CAB93731 (EMBL:AL357613) Streptomyces coelicolor hypothetical 23.8 kD protein SC5F8.03c%2C 225 aa%3B fasta scores: opt: 439 z-score: 523.3 E(): 1.1e-21%3B 37.8%25 identity in 222 aa overlap gene gene5248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5196 SCO5197 SCO5197 2SC3B6.21 2SC3B6.21 5654618 5655373 + hypothetical protein 2SC3B6.21%2C conserved hypothetical protein%2C len: 251 aa%3B similar to TR:CAB93731 (EMBL:AL357613) Streptomyces coelicolor hypothetical 23.8 kD protein SC5F8.03c%2C 225 aa%3B fasta scores: opt: 449 z-score: 539.1 E(): 1.5e-22%3B 35.7%25 identity in 230 aa overlap gene gene5249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5197 SCO5198 SCO5198 2SC3B6.22c 2SC3B6.22c 5655433 5655948 - hypothetical protein 2SC3B6.22c%2C hypothetical protein%2C len: 171 aa%3B low similarity to TR:Q9S2D5 (EMBL:AL110470) Streptomyces coelicolor MutT domain containing protein%2C 204 aa%3B fasta scores: opt: 139 z-score: 184.0 E(): 0.0088%3B 30.8%25 identity in 120 aa overlap gene gene5250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5198 SCO5199 SCO5199 2SC3B6.23c 2SC3B6.23c 5655945 5657408 - hypothetical protein 2SC3B6.23c%2C conserved hypothetical protein%2C len: 487 aa%3B similar to TR:O53341 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 49.4 kD protein%2C 472 aa%3B fasta scores: opt: 1382 z-score: 1331.8 E(): 0%3B 46.2%25 identity in 489 aa overlap gene gene5251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5199 SCO5200 SCO5200 2SC3B6.24 2SC3B6.24 5657601 5658722 + hypothetical protein 2SC3B6.24%2C membrane protein%2C len: 373 aa%3B similar to TR:Q9WX08 (EMBL:AL079345) Streptomyces coelicolor epimerase SCE68.24c%2C 353 aa%3B fasta scores: opt: 307 z-score: 353.0 E(): 3.4e-12%3B 29.1%25 identity in 320 aa overlap. Contains possible N-terminal region signal sequence peptide and possible hydrophobic membrane spanning region at C-terminal domain gene gene5252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5200 SCO5201 SCO5201 2SC3B6.25 2SC3B6.25 5658833 5659291 + moaE-like protein 2SC3B6.25%2C moaE-like protein%2C len: 152 aa%3B similar to SW:MOAE_ECOLI (EMBL:X70420) Escherichia coli molybdopterin [mpt] converting factor%2C subunit 2 MoaE%2C 149 aa%3B fasta scores: opt: 255 z-score: 317.2 E(): 3.3e-10%3B 33.3%25 identity in 129 aa overlap gene gene5253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5201 SCO5202 SCO5202 2SC3B6.26 2SC3B6.26 5659650 5660744 + hypothetical protein 2SC3B6.26%2C possible hypothetical protein%2C len: 364 aa%3B similar to TR:O53340 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 35.5. kD protein%2C 340 aa%3B fasta scores: opt: 430 z-score: 467.4 E(): 1.4e-18%3B 41.3%25 identity in 361 aa overlap. Contains possible N-terminal signal peptide sequence gene gene5254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5202 SCO5203 SCO5203 2SC3B6.27c 2SC3B6.27c 5660775 5661446 - hypothetical protein 2SC3B6.27c%2C unknown%2C len: 223 aa. Contains two TTA leucine codons%2C possible targets for bldA regulation gene gene5255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5203 SCO5204 SCO5204 2SC3B6.28 2SC3B6.28 5661482 5664484 + hypothetical protein SC7E4.01%2C hypothetical protein (fragment)%2C len: >220 aa%3B similar to C-terminal part of TR:O32904 (EMBL:Z98271) Mycobacterium leprae hypothetical 29.1 kD protein MLCB1779.46%2C 277 aa%3B fasta scores: opt: 236 z-score: 242.2 E(): 5.1e-06%3B 33.5%25 identity in 191 aa overlap. Contains possible colied-coil region at aprox. residues 151..172 and a 5x degenerate repeat: (G/D/S)DK(2)~2SC3B6.28%2C possible integral membrane protein (fragment)%2C len: >815 aa%3B similar to TR:O53609 (EMBL:AL021428) Mycobacterium tuberculosis membrane protein MTV030.07%2C 979 aa%3B fasta scores: opt: 992 z-score: 1094.5 E(): 0%3B 41.1%25 identity in 829 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5204 SCO5205 SCO5205 SC7E4.02 SC7E4.02 5664876 5666699 + hypothetical protein SC7E4.02%2C hypothetical protein%2C len: 607 aa%3B similar to TR:CAB83499 (EMBL:AL162752) Neisseria meningitidis hypothetical 51.6 kD protein NMA0184%2C 468 aa%3B fasta scores: opt: 268 z-score: 307.6 E(): 1.2e-09%3B 29.5%25 identity in 528 aa overlap gene gene5258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5205 SCO5206 SCO5206 catR catR 5666944 5667360 - hydrogen peroxide sensitive repressor SC7E4.03c%2C catR%2C hydrogen peroxide sensitive repressor%2C len: 138 aa%3B identical to previously sequenced TR:Q9RN70 (EMBL:AF186372) Streptomyces coelicolor hydrogen peroxide sensitive repressor CatR%2C 138 aa. Contains Pfam match to entry PF01475 FUR%2C Ferric uptake regulator family gene gene5260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5206 SCO5207 SCO5207 SC7E4.04c SC7E4.04c 5667547 5667984 - hypothetical protein SC7E4.04c%2C hypothetical protein%2C len: 145 aa%3B similar to TR:Q9YFH9 (EMBL:AP000058) Aeropyrum pernix hypothetical 15.7 kD protein APE0267%2C 143 aa%3B fasta scores: opt: 220 z-score: 282.8 E(): 2.8e-08%3B 34.1%25 identity in 126 aa overlap. Contains 2x Pfam match to entry PF00571 CBS%2C CBS domain gene gene5261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5207 SCO5208 SCO5208 SC7E4.05c SC7E4.05c 5668087 5668887 - monophosphatase SC7E4.05c%2C probable monophosphatase%2C len: 266 aa%3B similar to SW:STRO_STRGR (EMBL:Y08763) Streptomyces griseus glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) StrO%2C 259 aa%3B fasta scores: opt: 316 z-score: 395.8 E(): 1.4e-14%3B 35.9%25 identity in 248 aa overlap. Contains 2x Pfam match to entry PF00459 inositol_P%2C Inositol monophosphatase family and match to Prosite entry PS00629 Inositol monophosphatase family signature 1 gene gene5262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5208 SCO5209 SCO5209 SC7E4.06 SC7E4.06 5669080 5669691 + TetR family transcriptional regulator SC7E4.06%2C possible tetR-family transcriptional regulator%2C len: 203 aa%3B similar to TR:Q9Z551 (EMBL:AL035212) Streptomyces coelicolor transcriptional regulator SC9B2.08c%2C 192 aa%3B fasta scores: opt: 169 z-score: 206.9 E(): 0.00047%3B 31.9%25 identity in 182 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 24..45 (+3.85 SD) gene gene5263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5209 SCO5210 SCO5210 SC7E4.07c SC7E4.07c 5669723 5670046 - molecular chaperone SC7E4.07c%2C possible molecular chaperone%2C len: 107 aa%3B similar to SW:SUGE_ECOLI (EMBL:X69949) Escherichia coli SugE protein%2C 105 aa%3B fasta scores: opt: 341 z-score: 449.1 E(): 1.5e-17%3B 44.7%25 identity in 103 aa overlap and to TR:CAB88839 (EMBL:AL353832) Streptomyces coelicolor sugE%2C SCE6.35c%2C 106 aa%3B fasta scores: opt: 323 z-score: 386.5 E(): 6e-16%3B 43.0%25 identity in 107 aa overlap. Contains Pfam match to entry PF00893 DUF7%2C Integral membrane protein and possible hydrophobic membrane spanning regions gene gene5264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5210 SCO5211 SCO5211 SC7E4.08c SC7E4.08c 5670249 5671262 - hypothetical protein SC7E4.08c%2C conserved hypothetical protein%2C len: 337 aa%3B similar to TR:O05873 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 34.9 kD protein MTCY20B11.03%2C 330 aa%3B fasta scores: opt: 1051 z-score: 1176.2 E(): 0%3B 52.7%25 identity in 338 aa overlap. Contains match to Prosite entryPS00017 ATP/GTP-binding site motif A (P-loop) gene gene5265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5211 SCO5212 SCO5212 aroA2 aroA2 5671275 5672591 - 3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis gene gene5266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5212 SCO5213 SCO5213 SC7E4.10c SC7E4.10c 5672715 5673437 - hypothetical protein SC7E4.10c%2C possible integral membrane protein%2C len: 240 aa%3B similar to TR:CAB89063 (EMBL:AL353872) Streptomyces coelicolor integral membrane protein SC5G8.12%2C 322 aa%3B fasta scores: opt: 126 z-score: 158.5 E(): 0.23%3B 25.6%25 identity in 160 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5213 SCO5214 SCO5214 SC7E4.11 SC7E4.11 5673488 5674303 + hypothetical protein SC7E4.11%2C hypothetical protein%2C len: 271 aa%3B similar to TR:O05872 (EMBL:Z95121) Mycobacterium tuberculosis hypothetical 27.6 kD protein MTCY20B11.01c%2C 252 aa%3B fasta scores: opt: 383 z-score: 460.8 E(): 3.4e-18%3B 39.6%25 identity in 283 aa overlap gene gene5268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5214 SCO5215 SCO5215 SC7E4.12 SC7E4.12 5674326 5674961 + hypothetical protein SC7E4.12%2C hypothetical protein%2C len: 211 aa%3B similar to TR:P96267 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 21.7 kD protein MTCY22G10.18c%2C 209 aa%3B fasta scores: opt: 255 z-score: 287.1 E(): 1.6e-08%3B 29.8%25 identity in 205 aa overlap gene gene5269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5215 SCO5216 SCO5216 SC7E4.13 SC7E4.13 5675219 5675902 + RNA polymerase sigma factor RpoE Member of the extracytoplasmic function sigma factors which are active under specific conditions%3B binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription%3B this sigma factor is involved in heat shock and oxidative stress response gene gene5270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5216 SCO5217 SCO5217 rsrA rsrA 5675899 5676216 + anti-sigma factor SC7E4.14%2C rsrA%2C anti-sigma factor%2C len: 105 aa%3B identical to previously sequenced TR:Q9RL96 (EMBL:AJ010320) Streptomyces coelicolor anti-sigma factor RsrA%2C 105 aa gene gene5271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5217 SCO5218 SCO5218 SC7E4.15 SC7E4.15 5676345 5677670 + hypothetical protein SC7E4.15%2C possible integral membrane protein%2C len: 441 aa%3B similar to TR:Q9X1H8 (EMBL:AE001797) Thermotoga maritima conserved hypothetical protein TM1467%2C 426 aa%3B fasta scores: opt: 471 z-score: 536.1 E(): 2.2e-22%3B 29.0%25 identity in 352 aa overlap. Contains possible N-terminal signal peptide sequence and possible hydrophobic membrane spanning regions gene gene5272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5218 SCO5219 SCO5219 SC7E4.16 SC7E4.16 5677676 5678932 + lipoprotein SC7E4.16%2C possible lipoprotein%2C len: 418 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions gene gene5273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5219 SCO5220 SCO5220 SC7E4.17 SC7E4.17 5679047 5680027 + hypothetical protein SC7E4.17%2C unknown%2C len: 326 aa gene gene5274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5220 SCO5221 SCO5221 SC7E4.18 SC7E4.18 5680107 5680757 + polypeptide deformylase SC7E4.18%2C probable polypeptide deformylase%2C len: 216 aa%3B similar to SW:DEF_FREDI (EMBL:Y10305) Fremyella diplosiphon polypeptide deformylase (EC 3.5.1.31) Def%2C 187 aa%3B fasta scores: opt: 353 z-score: 430.0 E(): 1.8e-16%3B 33.8%25 identity in 145 aa overlap and to TR:Q9XAQ2 (EMBL:AL078618) Streptomyces coelicolor polypeptide deformylase SC10A7.23%2C 208 aa%3B fasta scores: opt: 680 z-score: 796.7 E(): 0%3B 59.8%25 identity in 169 aa overlap. Contains Pfam match to entry PF01327 Pep_deformylase%2C Polypeptide deformylase gene gene5275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5221 SCO5222 SCO5222 SC7E4.19 SC7E4.19 5681016 5682101 + lyase SC7E4.19%2C possible lyase%2C len: 361 aa%3B similar to SW:PTLS_STRSQ (EMBL:U05213) Streptomyces sp. pentalenene synthase (EC 4.6.1.5)%2C 336 aa%3B fasta scores: opt: 254 z-score: 317.5 E(): 3.3e-10%3B 23.8%25 identity in 311 aa overlap. Contains match to Prosite entry PS00904 Protein prenyltransferases alpha subunit repeat signature and a TTA leucine codon%2C possible target for bldA regulation gene gene5276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5222 SCO5223 SCO5223 SC7E4.20 SC7E4.20 5682098 5683483 + cytochrome P450 SC7E4.20%2C probable cytochrome P450%2C len: 461 aa%3B similar to SW:CP51_HUMAN (EMBL:U23942) Homo sapiens cytochrome P450 51 (EC 1.14.14.1) Cyp51%2C 503 aa%3B fasta scores: opt: 532 z-score: 587.2 E(): 3.1e-25%3B 25.7%25 identity in 447 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 gene gene5277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5223 SCO5224 SCO5224 SC7E4.21c SC7E4.21c 5683497 5684465 - AraC family transcription regulator SC7E4.21c%2C probable araC-family transcriptional regulator%2C len: 322 aa%3B similar to TR:Q9S166 (EMBL:AB023785) Streptomyces griseus transcriptional activator for strR%2C AdpA%2C 405 aa%3B fasta scores: opt: 1005 z-score: 1177.5 E(): 0%3B 49.2%25 identity in 325 aa overlapand to TR:CAB87229 (EMBL:AL163641) Streptomyces coelicolor araC-family transcriptional regulator AdpA%2C 398 aa%3B fasta scores: opt: 990 z-score: 1160.1 E(): 0%3B 48.9%25 identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and match to Prosite entry PS00041 Bacterial regulatory proteins%2C araC family signature. Contains also a possible helix-turn-helix motif at residues 230..251 (+3.72 SD) gene gene5278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5224 SCO5225 SCO5225 nrdM nrdM 5684737 5685768 - ribonucleotide-diphosphate reductase small chain SC7E4.22c%2C nrdM%2C ribonucleotide-diphosphate reductase small chain%2C len: 343 aa%3B identical to previously sequenced TR:CAB82486 (EMBL:AJ276618) Streptomyces coelicolor A3(2) ribonucleotide-diphosphate reductase small chain (EC 1.17.4.1) NrdM%2C 343 aa. Contains Pfam match to entry PF00268 ribonuc_red%2C Ribonucleotide reductases and a possible hydrophobic membrane spanning region gene gene5279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5225 SCO5226 SCO5226 nrdL nrdL 5685768 5688143 - ribonucleotide-diphosphate reductase large chain SC7E4.23c%2C nrdL%2C ribonucleotide-diphosphate reductase large chain%2C len: 791 aa%3B identical to previously sequenced TR:CAB82485 (EMBL:AJ276618) Streptomyces coelicolor A3(2) ribonucleotide-diphosphate reductase large chain (EC 1.17.4.1) NrdL%2C 791 aa. Contains Pfam match to entry PF00317 ribonucleo_red%2C Ribonucleotide reductase and match to Prosite entry PS00089 Ribonucleotide reductase large subunit signature gene gene5280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5226 SCO5227 SCO5227 nrdX nrdX 5688140 5688415 - redoxin SC7E4.24c%2C nrdX%2C redoxin%2C len: 91 aa%3B identical to previously sequenced TR:CAB82484 (EMBL:AJ276618) Streptomyces coelicolor A3(2) redoxin NrdX%2C 91 aa. Doubtful CDS: Frameplot and Correlation Scores indicate that this CDS might not be a gene gene gene5281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5227 SCO5228 SCO5228 SC7E4.25c SC7E4.25c 5688494 5689000 - acetyltransferase SC7E4.25c%2C possible acetyltransferase%2C len: 168 aa%3B similar to TR:Q9S2P7 (EMBL:AL096872) Streptomyces coelicolor acetyltransferase SC5F7.12c%2C 169 aa%3B fasta scores: opt: 151 z-score: 187.3 E(): 0.0058%3B 36.2%25 identity in 141 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene5282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5228 SCO5229 SCO5229 SC7E4.26c SC7E4.26c 5689073 5690671 - permease SC7E4.26c%2C probable permease%2C len: 4532 aa%3B similar to TR:Q47552 (EMBL:L01152) Escherichia coli proline permease (fragment) PutP%2C 489 aa%3B fasta scores: opt: 333 z-score: 378.7 E(): 1.3e-13%3B 23.8%25 identity in 495 aa overlap. Contains Pfam match to entry PF00474 SSF%2C Sodium:solute symporter family. Contains also possible hydrophobic membrane spanning regions gene gene5283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5229 SCO5230 SCO5230 SC7E4.27c SC7E4.27c 5690680 5690964 - hypothetical protein SC7E4.27c%2C possible integral membrane protein%2C len: 94 aa. Contains possible hydrophobic membrane spanning regions gene gene5284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5230 SCO5231 SCO5231 SC7E4.28c SC7E4.28c 5691072 5691836 - GntR family transcriptional regulator SC7E4.28c%2C probable gntR-family transcriptional regulator%2C len: 254 aa%3B similar to SW:HUTC_PSEPU (EMBL:M33922) Pseudomonas putida histidine utilization repressor HutC%2C 248 aa%3B fasta scores: opt: 355 z-score: 415.1 E(): 1.2e-15%3B 31.6%25 identity in 234 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and match to Prosite entry PS00043 Bacterial regulatory proteins%2C gntR family signature. Contains also a possible helix-turn-helix motif at residues 45..66 (+3.08 SD) gene gene5285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5231 SCO5232 SCO5232 SC7E4.29 SC7E4.29 5692292 5693569 + sugar transporter sugar binding protein SC7E4.29%2C possible sugar transporter sugar binding protein%2C len: 425 aa%3B similar to TR:Q9RK79 (EMBL:AL132662) Streptomyces coelicolor sugar transporter sugar binding protein SCF11.11%2C 422 aa%3B fasta scores: opt: 917 z-score: 991.5 E(): 0%3B 37.9%25 identity in 417 aa overlap and to SW:MALX_STRPN (EMBL:L08611) Streptococcus pneumoniae maltose/maltodextrin-binding protein precursor MalX%2C 423 aa%3B fasta scores: opt: 312 z-score: 340.7 E(): 1.7e-11%3B 22.9%25 identity in 428 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene5286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5232 SCO5233 SCO5233 SC7E4.30 SC7E4.30 5693658 5694644 + sugar transporter integral membrane protein SC7E4.30%2C possible sugar transporter integral membrane protein%2C len: 328 aa%3B similar to TR:Q9RK78 (EMBL:AL132662) Streptomyces coelicolor sugar transporter integral membrane protein SCF11.12%2C 302 aa%3B fasta scores: opt: 907 z-score: 1004.1 E(): 0%3B 46.6%25 identity in 298 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and possible hydrophobic membrane spanning regions gene gene5287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5233 SCO5234 SCO5234 SC7E4.31 SC7E4.31 5694641 5695471 + sugar transporter integral membrane protein SC7E4.31%2C possible sugar transporter integral membrane protein%2C len: 276 aa%3B similar to TR:Q9RK77 (EMBL:AL132662%3B) Streptomyces coelicolor sugar transporter integral membrane protein SCF11.13%2C 285 aa%3B fasta scores: opt: 1027 z-score: 1227.9 E(): 0%3B 54.3%25 identity in 278 aa overlap and to TR:Q9R9Q5 (EMBL:AF175299) Rhizobium meliloti inner membrane permease ThuG%2C 276 aa%3B fasta scores: opt: 554 z-score: 666.6 E(): 1.2e-29%3B 33.8%25 identity in 266 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene5288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5234 SCO5235 SCO5235 SC7E4.32 SC7E4.32 5695480 5696970 + sugar hydrolase SC7E4.32%2C possible sugar hydrolase%2C len: 496 aa%3B similar to SW:HEXA_ALTSO (EMBL:D17399) Alteromonas sp. beta-hexosaminidase A precursor (EC 3.2.1.52) Cht60%2C 598 aa%3B fasta scores: opt: 486 z-score: 525.0 E(): 9e-22%3B 34.4%25 identity in 363 aa overlap and to TR O69862 (EMBL:AL023702%3B) Streptomyces coelicolor hydrolase SC1C3.20c%2C 506 aa%3B fasta scores: opt: 1849 z-score: 1988.9 E(): 0%3B 60.6%25 identity in 498 aa overlap. Contains Pfam match to entry PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3 N terminal domain gene gene5289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5235 SCO5236 SCO5236 nagB nagB 5697291 5698076 - glucosamine-6-phosphate deaminase catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate gene gene5290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5236 SCO5237 SCO5237 SC7E4.34c SC7E4.34c 5698211 5698963 - oxidoreductase SC7E4.34c%2C probable oxidoreductase%2C len: 250 aa%3B highly similar to TR:Q9RKS8 (EMBL:AL132824) Streptomyces coelicolor reductase SCAH10.29%2C 262 aa%3B fasta scores: opt: 807 z-score: 863.1 E(): 0%3B 52.4%25 identity in 252 aa overlap and to SW:VER1_ASPPA (EMBL:M91369) Aspergillus parasiticus versicolorin reductase (EC 1.1.-.-) Ver1%2C 262 aa%3B fasta scores: opt: 469 z-score: 506.7 E(): 9.4e-21%3B 39.2%25 identity in 255 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus gene gene5291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5237 SCO5238 SCO5238 SC7E4.35 SC7E4.35 5699058 5699702 + TetR family transcriptional regulator SC7E4.35%2C possible TetR family transcriptional regulator%2C len: 214 aa%3B similar to TR:CAB69777 (EMBL:AL137187) Streptomyces coelicolor tetR-family transcriptional regulator SC7A8.28%2C 194 aa%3B fasta scores: opt: 326 z-score: 399.8 E(): 8.5e-15%3B 34.9%25 identity in 192 aa overlap and to TR:CAB93063 (EMBL:AL357432) Streptomyces coelicolor transcriptional regulator SCD95A.36c%2C 202 aa%3B fasta scores: opt: 458 z-score: 451.3 E(): 1.5e-19%3B 41.8%25 identity in 194 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene5292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5238 SCO5239 SCO5239 2SC7G11.01 2SC7G11.01 5700131 5701606 + histidine kinase 2SC7G11.01%2C possible histidine kinase%2C len: 491 aa%3B similar to TR:O05846 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 54.0 kDa protein MTCY07D11.06%2C 501 aa%3B fasta scores: opt: 1038 z-score: 1176.8 E(): 0%3B 48.9%25 identity in 380 aa overlap and to TR:O26226 (EMBL:AE000801) Methanobacterium thermoautotrophicum sensory transduction histidine kinase MTH123%2C 356 aa%3B fasta scores: opt: 372 z-score: 426.7 E(): 2.7e-16%3B 29.9%25 identity in 321 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase gene gene5293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5239 SCO5240 SCO5240 2SC7G11.02c 2SC7G11.02c 5701855 5702112 - hypothetical protein 2SC7G11.02c%2C wblE%2C hypothetical protein%2C len: 85 aa%3B identical to previously sequenced TR:Q9X952 (EMBL:AJ239087) Streptomyces coelicolor hypothetical 9.7 kDa protein WblE%2C 85 aa gene gene5294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5240 SCO5241 SCO5241 2SC7G11.03c 2SC7G11.03c 5702433 5703401 - hypothetical protein 2SC7G11.03c%2C hypothetical protein%2C len: 322 aa%3B similar to TR:O05848 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 34.5 kDa protein MTCY07D11.08c%2C 321 aa%3B fasta scores: opt: 694 z-score: 788.3 E(): 0%3B 39.9%25 identity in 328 aa overlap. Contains Pfam match to entry PF00781 DAGKc%2C Diacylglycerol kinase catalytic domain (presumed) gene gene5295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5241 SCO5242 SCO5242 2SC7G11.04 2SC7G11.04 5703529 5703987 + hypothetical protein 2SC7G11.04%2C possible integral membrane protein%2C len: 152 aa%3B similar to TR:O05849 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 14.3 kDa protein MTCY07D11.09%2C 143 aa%3B fasta scores: opt: 177 z-score: 215.5 E(): 0.00015%3B 33.8%25 identity in 136 aa overlap gene gene5296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5242 SCO5243 SCO5243 2SC7G11.05c 2SC7G11.05c 5704007 5705092 - RNA polymerase sigma factor 2SC7G11.05c%2C sig1%2C RNA polymerase sigma factor%2C len: 361 aa%3B identical to previously sequenced TR:Q9RIT0 (EMBL:AJ249450) Streptomyces coelicolor A3(2) Sig1 protein%2C 361 aa and similar TR:CAB93744 (EMBL:AL357613) Streptomyces coelicolor regulatory protein SC5F8.16c%2C 83 aa%3B fasta scores: opt: 414 z-score: 534.4 E(): 3.9e-24%3B 72.0%25 identity in 82 aa overlap. Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and possible helix-turn-helix motif at residues 326..347 (+7.10 SD) gene gene5297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5243 SCO5244 SCO5244 2SC7G11.06c 2SC7G11.06c 5705089 5705502 - anti-sigma factor 2SC7G11.06c%2C prs1%2C anti-sigma factor%2C len: 137 aa%3B identical to previously sequenced TR:Q9R3X8 (EMBL:AJ249450) Streptomyces coelicolor A3(2) regulator of Sig1%2C Prs1 protein or UshX%2C 137 aa gene gene5298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5244 SCO5245 SCO5245 2SC7G11.07c 2SC7G11.07c 5705753 5706013 - hypothetical protein 2SC7G11.07c%2C hypothetical protein%2C len: 86 aa%3B identical to previously sequenced TR:Q9R3I9 (EMBL:AJ249450) Streptomyces coelicolor A3(2) hypothetical 9.6 kDa protein UshY%2C 86 aa. Contains Pfam match to entry PF02148 zf-UBP%2C Zn-finger in ubiquitin-hydrolases and other proteins gene gene5299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5245 SCO5246 SCO5246 2SC7G11.08 2SC7G11.08 5706075 5707667 + Na+/H+ antiporter 2SC7G11.08%2C possible Na+/H+ antiporter%2C len: 530 aa%3B identical to C-terminal region of previously sequenced TR:Q9RPC9 (EMBL:AF162936) Streptomyces coelicolor A3(2) Na/H antiporter homolog (fragment)%2C 212 aa and similar to SW:YJCE_ECOLI: (EMBL:U00006) Escherichia coli Na(+)/H(+) exchanger YjcE%2C 549 aa%3B fasta scores: opt: 516 z-score: 557.0 E(): 1.5e-23%3B 30.1%25 identity in 552 aa overlap. Contains Pfam match to entry PF00999 Na_H_Exchanger%2C Sodium/hydrogen exchanger family and possible hydrophobic membrane spanning regions gene gene5300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5246 SCO5247 SCO5247 2SC7G11.09c 2SC7G11.09c 5707716 5708624 - deaminase 2SC7G11.09c%2C possible deaminase%2C len: 302 aa%3B similar to SW:1A1D_PYRHO (EMBL:AP000001) Pyrococcus horikoshii 1-aminocyclopropane-1-carboxylate deaminase (EC 4.1.99.4) PHBE027%2C 325 aa%3B fasta scores: opt: 274 z-score: 309.9 E(): 8.6e-10%3B 29.7%25 identity in 283 aa overlap gene gene5301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5247 SCO5248 SCO5248 2SC7G11.10c 2SC7G11.10c 5708738 5709316 - hypothetical protein 2SC7G11.10c%2C hypothetical protein%2C len: 192 aa%3B similar to TR:O06288 (EMBL:Z95557) Mycobacterium tuberculosis hypothetical 30.6 kDa protein MTCY07H7.28c%2C 275 aa%3B fasta scores: opt: 180 z-score: 221.9 E(): 6.8e-05%3B 31.8%25 identity in 176 aa overlap gene gene5302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5248 SCO5249 SCO5249 2SC7G11.11 2SC7G11.11 5709624 5711030 + nucleotide-binding protein 2SC7G11.11%2C possible nucleotide-binding protein%2C len: 468 aa%3B highly similar to TR:Q54255 (EMBL:L76204) Streptomyces griseus sporulation protein%2C 470 aa%3B fasta scores: opt: 2008 z-score: 2272.9 E(): 0%3B 64.1%25 identity in 462 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding%2C Cyclic nucleotide-binding domain gene gene5303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5249 SCO5250 SCO5250 2SC7G11.12 2SC7G11.12 5711116 5712276 + polyprenyl synthetase 2SC7G11.12%2C gtr%2C polyprenyl synthetase%2C len: 386 aa%3B previously sequenced as TR:Q9RGW1 (EMBL:AF104994) Streptomyces coelicolor A3(2) geranyl transferase Gtr%2C 386 aa. Contains Pfam match to entry PF00348 polyprenyl_synt%2C Polyprenyl synthetases and match to Prosite entry PS00723 Polyprenyl synthetases signature 1 gene gene5304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5250 SCO5251 SCO5251 2SC7G11.13 2SC7G11.13 5712608 5713246 + acetyltransferase 2SC7G11.13%2C pat%2C acetyltransferase%2C len: 212 aa%3B previously sequenced as TR:Q9RGW2 (EMBL:AF104994) Streptomyces coelicolor A3(2) puromycin N-acetyltransferase Pat%2C 210 aa. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene5305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5251 SCO5252 SCO5252 2SC7G11.14 2SC7G11.14 5713322 5713906 + hypothetical protein 2SC7G11.14%2C hypothetical protein%2C len: 194 aa%3B previously sequenced as TR:Q9RGW3 (EMBL:AF104994) Streptomyces coelicolor A3(2) hypothetical 18.8 kDa protein%2C 169 aa gene gene5306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5252 SCO5253 SCO5253 2SC7G11.15 2SC7G11.15 5713933 5714154 + hypothetical protein 2SC7G11.15%2C unknown%2C len: 73 aa gene gene5307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5253 SCO5254 SCO5254 2SC7G11.16c 2SC7G11.16c 5714262 5714657 - superoxide dismutase 2SC7G11.16c%2C sodN%2C superoxide dismutase%2C len: 131 aa%3B previously sequenced as TR:O51921 (EMBL:AF104994) Streptomyces coelicolor superoxide dismutase (EC 1.15.1.1) SodN%2C 131 aa gene gene5308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5254 SCO5255 SCO5255 2SC7G11.17 2SC7G11.17 5714800 5715240 + signal peptidase 2SC7G11.17%2C signal peptidase%2C len: 146 aa%3B previously sequenced as TR:O51920 (EMBL:AF104994) Streptomyces coelicolor signal peptidase-like protein%2C 148 aa. Contains Pfam match to entry PF00461 Peptidase_S26%2C Signal peptidase I and match to Prosite entry PS00501 Signal peptidases I serine active site gene gene5309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5255 SCO5256 SCO5256 2SC7G11.18c 2SC7G11.18c 5715144 5715773 - hypothetical protein 2SC7G11.18c%2C hypothetical protein%2C len: 209 aa%3B similar to TR:CAB70944 (EMBL:AL137778) Streptomyces coelicolor hypothetical 20.3 kDa protein SCL2.32%2C 186 aa%3B fasta scores: opt: 314 z-score: 396.2 E(): 1.3e-14%3B 36.6%25 identity in 183 aa overlap gene gene5310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5256 SCO5257 SCO5257 2SC7G11.19 2SC7G11.19 5715872 5716681 + methyltransferase 2SC7G11.19%2C metZ%2C methyltransferase%2C len: 269 aa%3B previously sequenced as TR:Q9RGW5 (EMBL:AF104994) Streptomyces coelicolor A3(2) methyltransferase MetZ%2C 268 aa gene gene5311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5257 SCO5258 SCO5258 2SC7G11.20c 2SC7G11.20c 5716760 5717521 - ATP-binding protein 2SC7G11.20c%2C atrC%2C ATP-binding protein%2C len: 253 aa%3B previously sequenced as TR:Q9RGW6 (EMBL:AF104994) Streptomyces coelicolor A3(2) ATP-binding protein AtrC%2C 239 aa. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5258 SCO5259 SCO5259 2SC7G11.21c 2SC7G11.21c 5717518 5718468 - permease 2SC7G11.21c%2C atrB%2C permease%2C len: 316 aa%3B previously sequenced as TR:Q9RGW7 (EMBL:AF104994) Streptomyces coelicolor A3(2) permease AtrB%2C 313 aa. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene5313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5259 SCO5260 SCO5260 2SC7G11.22c 2SC7G11.22c 5718499 5719461 - hypothetical protein 2SC7G11.22c%2C atrA%2C hypothetical protein%2C len: 321 aa%3B identical to previously sequenced TR:Q9RGW8 (EMBL:AF104994) Streptomyces coelicolor A3(2) periplasmic binding protein AtrA%2C 321 aa. Contains Pfam match to entry PF00497 SBP_bac_3%2C Bacterial extracellular solute-binding proteins%2C family 3 and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene5314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5260 SCO5261 SCO5261 2SC7G11.23 2SC7G11.23 5720101 5721330 + malate oxidoreductase 2SC7G11.23%2C probable malate oxidoreductase%2C len: 409 aa%3B similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38)%2C 478 aa%3B fasta scores: opt: 1385 z-score: 1470.9 E(): 0%3B 55.0%25 identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic%2C Malic enzyme gene gene5315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5261 SCO5262 SCO5262 2SC7G11.24 2SC7G11.24 5721695 5722660 + dehydrogenase 2SC7G11.24%2C possible dehydrogenase%2C len: 321 aa%3B similar to SW:ADH3_BACST (EMBL:Z27089) Bacillus stearothermophilus alcohol dehydrogenase (EC 1.1.1.1)%2C 339 aa%3B fasta scores: opt: 303 z-score: 344.3 E(): 1e-11%3B 28.0%25 identity in 328 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene5316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5262 SCO5263 SCO5263 2SC7G11.25 2SC7G11.25 5722998 5723564 + hypothetical protein 2SC7G11.25%2C unknown%2C len: 188 aa gene gene5317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5263 SCO5264 SCO5264 2SC7G11.26c 2SC7G11.26c 5723633 5724715 - hypothetical protein 2SC7G11.26c%2C unknown%2C len: 360 aa. Contains possible coiled-coil region at approx. residues 157..212. High content in alanine%2C glutamic acid and arginine amino acid residues. Also highly hydrophilic gene gene5318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5264 SCO5265 SCO5265 2SC7G11.27c 2SC7G11.27c 5724717 5725718 - hypothetical protein 2SC7G11.27c%2C hypothetical protein%2C len: 333 aa%3B low similarity to TR:O32200 (EMBL:Z99120) Bacillus subtilis YvqG protein%2C 240 aa%3B fasta scores: opt: 172 z-score: 193.3 E(): 0.0027%3B 25.0%25 identity in 244 aa overlap gene gene5319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5265 SCO5266 SCO5266 2SC7G11.28 2SC7G11.28 5725804 5726637 + hypothetical protein 2SC7G11.28%2C membrane protei%2C len: 277 aa%3B similar to N-terminal region of TR:CAB76994 (EMBL:AL159178) Streptomyces coelicolor integral membrane protein SCH22.25%2C 456 aa%3B fasta scores: opt: 141 z-score: 157.1 E(): 0.28%3B 29.3%25 identity in 263 aa overlap. Contains matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Contains possible hydrophobic membrane spanning region gene gene5320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5266 SCO5267 SCO5267 2SC7G11.29c 2SC7G11.29c 5726890 5727075 - hypothetical protein 2SC7G11.29c%2C unknown%2C len: 61 aa. High content in glutamic acid amino acid residues gene gene5321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5267 SCO5268 SCO5268 2SC7G11.30 2SC7G11.30 5727255 5727725 + hypothetical protein 2SC7G11.30%2C unknown%2C len: 156 aa gene gene5322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5268 SCO5269 SCO5269 2SC7G11.31 2SC7G11.31 5727722 5729959 + hypothetical protein 2SC7G11.31%2C unknown%2C len: 745 aa. Contains 2 conserved repeat regions: 2x GENPEY and 4x GHGAYP gene gene5323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5269 SCO5270 SCO5270 2SC7G11.32 2SC7G11.32 5730129 5731151 + hypothetical protein 2SC7G11.32%2C conserved hypothetical protein%2C len: 340 aa%3B similar to TR:CAB86114 (EMBL:AL163003) Streptomyces coelicolor hypothetical 37.1 kDa protein SCC24.20%2C 340 aa%3B fasta scores: opt: 1113 z-score: 1224.6 E(): 0%3B 54.5%25 identity in 343 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5270 SCO5271 SCO5271 2SC7G11.33c 2SC7G11.33c 5731309 5734599 + hypothetical protein 2SC7G11.33%2C hypothetical protein%2C len: 1096 aa%3B similar to TR:CAB86115 (EMBL:AL163003) Streptomyces coelicolor hypothetical 145.7 kDa protein SCC24.21%2C 1349 aa%3B fasta scores: opt: 758 z-score: 652.1 E(): 7.4e-29%3B 29.8%25 identity in 1157 aa overlap. Contains a possible coiled-coil region at approx. residues 1011..1029 gene gene5325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5271 SCO5272 SCO5272 2SC7G11.34 2SC7G11.34 5734620 5734814 + hypothetical protein 2SC7G11.34%2C unknown%2C len: 64 aa gene gene5326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5272 SCO5273 SCO5273 2SC7G11.35 2SC7G11.35 5734882 5736744 + hypothetical protein 2SC7G11.35%2C hypothetical protein%2C len: 620 aa%3B N-terminal region similar to SW:ASLB_ECOLI (EMBL:M87049) Escherichia coli arylsulfatase regulatory protein AslB%2C 411 aa%3B blastp (consecutive) scores: Score%3D 166 (58.4 bits)%2C Expec %3D 2.6e-19%2C Sum P(2)%3D 2.6e-19%2C Identities%3D 57/184 (30%25)%2C Positives%3D 82/184 (44%25) and Score%3D 141 (49.6 bits)%2C Expect%3D 2.6e-19%2C Sum P(2 %3D 2.6e-19%2C Identities%3D 47/165 (28%25)%2C Positives%3D 73/165 (44%25). Contains Pfam match to entry PF01444 MoaA_NifB_PqqE%2C moaA / nifB / pqqE family gene gene5327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5273 SCO5274 SCO5274 2SC7G11.36 2SC7G11.36 5736744 5738369 + hypothetical protein 2SC7G11.36%2C unknown%2C len: 541 aa. High content in alanine amino acid residues and in G+C (77.57%25). Also contains 3x degenerate repeat: DA(P/T)GA(W/R)(G/S)(T/S)(4) gene gene5328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5274 SCO5275 SCO5275 2SC7G11.37 2SC7G11.37 5738498 5741521 + ATP/GTP binding protein 2SC7G11.37%2C possible ATP/GTP binding protein%2C len: 1007 aa%3B similar to (EMBL:AL391588) Streptomyces coelicolor SCCB12.04%2C 1148 aa%3B fasta scores: opt: 4019 z-score: 3915.8 E(): 0%3B 62.6%25 identity in 994 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5275 SCO5276 SCO5276 2SC7G11.38 2SC7G11.38 5741653 5742078 + hypothetical protein 2SC7G11.38%2C conserved hypothetical protein%2C len: 141 aa%3B similar to TR:CAB86112 (EMBL:AL163003) Streptomyces coelicolor hypothetical 16.0 kDa protein SCC24.18%2C 153 aa%3B fasta scores: opt: 178 z-score: 212.6 E(): 0.00023%3B 32.4%25 identity in 145 aa overlap gene gene5330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5276 SCO5277 SCO5277 2SC7G11.39 2SC7G11.39 5742087 5743016 + magnesium chelatase SCCB12.01%2C possible ion chelatase subunit (fragment)%2C len: >98 aa%3B similar to SW:BCHI_RHOCA (EMBL:Z11165) Rhodobacter capsulatus magnesium-chelatase 38 Kda subunit (MG-protoporphyrin IX chelatase) BchI%2C 350 aa%3B fasta scores: opt: 163 z-score: 216.2 E(): 0.00014%3B 38.1%25 identity in 97 aa overlap~2SC7G11.39%2C possible magnesium chelatase (fragment)%2C len: >248 aa%3B similar to SW:BCHI_CHLVI (EMBL:Z83933) Chlorobium vibrioforme magnesium-chelatase 38 kDa subunit (MG-protoporphyrin IX chelatase) BchI%2C 346 aa%3B fasta scores: opt: 441 z-score: 520.9 E(): 1.5e-21%3B 38.5%25 identity in 283 aa overlap. Contains Pfam match to entry PF01078 Mg_chelatase%2C Magnesium chelatase%2C subunit ChlI gene gene5331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5277 SCO5278 SCO5278 SCCB12.02 SCCB12.02 5743022 5744989 + magnesium chelatase SCCB12.02%2C possible ion chelatase%2C len: 655 aa%3B similar to TR: SW:CHLD_SYNP7 (EMBL:AB003135) Synechococcus sp. magnesium-chelatase subunit ChlD (MG-protoporphyrin IX chelatase) ChlD%2C 677 aa%3B fasta scores: opt: 304 z-score: 269.4 E(): 1.5e-07%3B 26.6%25 identity in 688 aa overlap gene gene5332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5278 SCO5279 SCO5279 SCCB12.03 SCCB12.03 5745066 5746304 + hypothetical protein SCCB12.03%2C unknown%2C len: 412 aa gene gene5333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5279 SCO5280 SCO5280 SCCB12.04 SCCB12.04 5746301 5749747 + ATP-binding protein SCCB12.04%2C possible ATP-binding protein%2C len: 1148 aa%3B similar to TR:CAB77406 (EMBL:AL160431) Streptomyces coelicolor ATP-binding protein SCD82.03%2C 966 aa%3B fasta scores: opt: 798 z-score: 834.6 E(): 0%3B 31.7%25 identity in 977 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5280 SCO5281 SCO5281 kgd kgd 5749846 5753664 - alpha-ketoglutarate decarboxylase kgd%3B produces succinic semialdehyde%3B part of alternative pathway from alpha-ketoglutarate to succinate%3B essential for normal growth gene gene5335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5281 SCO5282 SCO5282 SCCB12.06c SCCB12.06c 5753949 5755076 - two-component system sensor kinase SCCB12.06c%2C possible two-component system sensor kinase%2C len: 375 aa%3B similar to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2%2C 535 aa%3B fasta scores: opt: 344 z-score: 382.3 E(): 7.9e-14%3B 32.5%25 identity in 335 aa overlap. Contains Pfam matches to entries PF00672 DUF5%2C HAMP domain and PF00512 signal%2C Histidine kinase. Also contains possible hydrophobic membrane spanning regions gene gene5336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5282 SCO5283 SCO5283 SCCB12.07c SCCB12.07c 5755073 5755807 - two-component system response regulator SCCB12.07c%2C possible two-component system response regulator%2C len: 244 aa%3B similar to TR:Q9ZEP4 (EMBL:AJ131213) Streptomyces coelicolor response regulator CseB or SCE94.09%2C 234 aa%3B fasta scores: opt: 632 z-score: 771.1 E(): 0%3B 44.3%25 identity in 230 aa overlap and to SW:RESD_BACSU (EMBL:L09228)%2C 240 aa%3B fasta scores: opt: 573 z-score: 699.9 E(): 1.6e-31%3B 39.7%25 identity in 234 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal gene gene5337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5283 SCO5284 SCO5284 SCCB12.08c SCCB12.08c 5755921 5756628 - hypothetical protein SCCB12.08c%2C hypothetical protein%2C len: 235 aa%3B similar to TR:Q9RVH7 (EMBL:AE001956) Deinococcus radiodurans hypothetical 24.5 kDa protein DR1052%2C 230 aa%3B fasta scores: opt: 403 z-score: 466.7 E(): 1.6e-18%3B 38.5%25 identity in 218 aa overlap and to SW:SPEE_ECOLI (EMBL:J02804) Escherichia coli spermidine synthase (EC 2.5.1.16) SpeE%2C 287 aa%3B fasta scores: opt: 173 z-score: 204.7 E(): 0.00063%3B 31.9%25 identity in 119 aa overlap gene gene5338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5284 SCO5285 SCO5285 lon lon 5756807 5759230 + ATP-dependent protease SCCB12.09%2C lon%2C ATP-dependent protease%2C len: 807 aa%3B similar to SW:LON_MYCSM (EMBL:AF030688) Mycobacterium smegmatis ATP-dependent protease LA (EC 3.4.21.53) Lon%2C 779 aa%3B fasta scores: opt: 2550 z-score: 2489.6 E(): 0%3B 64.7%25 identity in 785 aa overlap. Contains Pfam matches to entries PF02190 LON%2C ATP-dependent protease La (LON) domain and PF00004 AAA%2C ATPases associated with various cellular activities (AAA) and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS01046 ATP-dependent serine proteases%2C lon family%2C serine active site gene gene5339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5285 SCO5286 SCO5286 SCCB12.10c SCCB12.10c 5759307 5760134 - hydrolase SCCB12.10c%2C probable hydrolase%2C len: 275 aa%3B similar to SW:LYCM_STRGL (EMBL:M30645) Streptomyces globisporus lysozyme M1 precursor (EC 3.2.1.17) Acm%2C 294 aa%3B fasta scores: opt: 828 z-score: 944.2 E(): 0%3B 45.7%25 identity in 291 aa overlap and to TR:Q9RJP9 (EMBL:AL132991) Streptomyces coelicolor lysozyme precursor SCF55.15%2C 279 aa%3B fasta scores: opt: 1425 z-score: 1618.9 E(): 0%3B 75.2%25 identity in 270 aa overlap. Contains Pfam match to entry PF01183 Glyco_hydro_25%2C Glycosyl hydrolases family 25 and 2x matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible N-terminal region signal peptide sequence (possibly cleavable) gene gene5340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5286 SCO5287 SCO5287 SCCB12.11 SCCB12.11 5760383 5760877 + MarR family transcriptional regulator SCCB12.11%2C possible MarR-family transcriptional regulator%2C len: 164 aa%3B similar to TR:Q9RL39 (EMBL: AL121596) Streptomyces coelicolor MarR-family protein SCF51.25%2C 148 aa%3B fasta scores: opt: 237 z-score: 290.2 E(): 1.1e-08%3B 37.6%25 identity in 141 aa overlap and to SW:YXAD_BACSU (EMBL:AB005554) Bacillus subtilis hypothetical transcriptional regulator on AsnH-GntR intergenic region YxaD%2C 143 aa%3B fasta scores: opt: 234 z-score: 286.9 E(): 1.6e-08%3B 35.7%25 identity in 140 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and possible helix-turn-helix motif at residues 72..93 (+3.73 SD) gene gene5341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5287 SCO5288 SCO5288 SCCB12.12c SCCB12.12c 5760899 5761690 - hypothetical protein SCCB12.12c%2C unknown%2C len: 263 aa gene gene5342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5288 SCO5289 SCO5289 cvnA5 cvnA5 5762200 5765139 + two component sensor kinase SCCB12.13%2C cvnA5%2C hypothetical protein (fragment)%2C len: >191 aa%3B similar to C-terminal region of TR:O86525 (EMBL:AL031124) Streptomyces coelicolor hypothetical 139.7 kDa protein SC1C2.25c%2C 1329 aa%3B fasta scores: opt: 146 z-score: 152.5 E(): 0.5%3B 25.3%25 identity in 186 aa overlap. Contains possible hydrophobic membrane spanning region~SC6G9.44c%2C possible sensor kinase%2C len: 806 aa%3B weak similarity to part of TR:O33492 (EMBL:AJ000330)%2C StyS%2C Pseudomonas sp. strain Y2 styrene sensor kinase (982 aa)%2C fasta scores%3B opt: 256 z-score: 230.5 E(): 1.6e-05%2C 24.7%25 identity in 543 aa overlap. Similar to parts of other S.coelicolor hypothetical proteins e.g. TR:O86525 (EMBL:AL031124) S.coelicolor hypothetical protein (1329 aa) (31.5%25 identity in 821 aa overlap). Contains 11x degenerate E(K/T)A repeats between codons 555 and 587. Contains probable coiled-coil from 251 to 295 (45 residues) (Max score: 1.500%2C probability 0.95). Contains Pfam match to entry PF00672 DUF5%2C Domain found in bacterial signal proteins and to entry PF00512 signal%2C Signal carboxyl-terminal domain gene gene5343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5289 SCO5290 SCO5290 cvnB5 cvnB5 5765214 5765666 + hypothetical protein SC6G9.43c%2C cvnB5%2C conserved hypothetical protein%2C len: 150 aa%3B similar to hypothetical proteins from S. coelicolor and Mycobacterium tuberculosis e.g. TR:O86524 (EMBL:AL031124) S.coelicolor hypothetical protein (173 aa)%2C fasta scores%3B opt: 316 z-score: 394.7 E(): 1.2e-14%2C 48.1%25 identity in 131 aa overlap and TR:O50393 (EMBL:AL009198) Mycobacterium tuberculosis hypothetical protein (130 aa) (36.7%25 identity in 120 aa overlap) gene gene5344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5290 SCO5291 SCO5291 cvnC5 cvnC5 5765663 5766115 + hypothetical protein SC6G9.42c%2C cvnC5%2C conserved hypothetical protein%2C len: 150 aa%3B similar to hypothetical proteins of varying length (divergent at the N-terminus) from S. coelicolor and Mycobacterium tuberculosis e.g. TR:O86523 (EMBL:AL031124) S.coelicolor hypothetical protein (132 aa)%2C fasta scores%3B opt: 250 z-score: 312.1 E(): 4.7e-10%2C 43.7%25 identity in 135 aa overlap and TR:O50392 (EMBL:AL009198) Mycobacterium tuberculosis hypothetical protein (122 aa) (37.4%25 identity in 131 aa overlap) gene gene5345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5291 SCO5292 SCO5292 cvnD5 cvnD5 5766162 5766737 + ATP/GTP-binding protein SC6G9.41c%2C cvnD5%2C possible ATP/GTP-binding protein%2C len: 191 aa%3B highly similar to others from S.coelicolor e.g. TR:O86519 (EMBL:AL031124) S.coelicolor possible ATP/GTP-binding protein (174 aa)%2C fasta scores%3B opt: 766 z-score: 918.0 E(): 0%2C 68.0%25 identity in 169 aa overlap. Although many of the presumed homologues start at the equivalent of codon 18 in this CDS%2C there is no possible initiation codon in this case. Also similar to hypothetical proteins from other organisms e.g. TR:O5039 (EMBL:AL009198) Mycobacterium tuberculosis hypothetical protein (193 aa) (63.6%25 identity in 173 aa overlap). Similar to the C-terminal half of TR:O26694 (EMBL:AE00084) Methanobacterium thermoautotrophicum conserved protein (393 aa) (29.5%25 identity in 173 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5292 SCO5293 SCO5293 SC6G9.40c SC6G9.40c 5766796 5768058 + oxygenase subunit SC6G9.40c%2C possible oxygenase subunit%2C len: 420 aa%3B similar to Pseudomonas spp. styrene monoxygenase large subunits e.g. TR:O06834 (EMBL:Z92524)%2C styA%2C Pseudomonas fluorescens main component of styrene monooxygenase (415 aa)%2C fasta scores%3B opt: 481 z-score: 542.1 E(): 7.3e-23%2C 31.2%25 identity in 417 aa overlap. It has no neighbouring CDS similar to the monoxygenase small subunit. The C-terminus overlaps the C-terminus of the downstream ORF on the opposite strand gene gene5347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5293 SCO5294 SCO5294 SC6G9.39 SC6G9.39 5768022 5769197 - hypothetical protein SC6G9.39%2C probable hypothetical protein%2C len: 391 aa%3B similar to mycobacterial hypothetical proteins e.g. TR:O69580 (EMBL:AL022602) Mycobacterium leprae probable hypothetical protein (374 aa)%2C fasta scores%3B opt: 347 z-score: 354.0 E(): 2.2e-12%2C 29.1%25 identity in 337 aa overlap. Similar to part of Listeria p60 attachment/invasion proteins e.g. SW:P60_LISWE (EMBL:M80354) Listeria welshimeri protein p60 precursor (524 aa) (37.8%25 identity in 98 aa overlap). Similar to other hypothetical proteins from S.coelicolor e.g. (EMBL:AL049497)%2C SC6G10.08C%2C S.coelicolor hypothetical protein (338 aa) (38.3%25 identity in 342 aa overlap). Contains possible N-terminal signal sequence. The C-terminus overlaps the C-terminus of the downstream ORF on the opposite strand. Contains probable coiled-coils from 43 to 98 (56 residues) ( Max score: 1.580%2C probability 0.99) and from 164 to 201 (38 residues) (Max score: 1.531%2C probability 0.97). Contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family (domain of unknown function) gene gene5348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5294 SCO5295 SCO5295 SC6G9.38 SC6G9.38 5769301 5769624 - hypothetical protein SC6G9.38%2C hypothetical protein%2C len: 107 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene5349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5295 SCO5296 SCO5296 SC6G9.37 SC6G9.37 5769695 5770348 - TetR family transcriptional regulator SC6G9.37%2C possible tetR-family transcriptional regulator%2C len: 217 aa%3B similar to many hypothetical proteins%2C especially from mycobacteria e.g. TR:Q49662 (EMBL:U00012) Mycobacterium leprae hypothetical protein (242 aa)%2C fasta scores%3B opt: 216 z-score: 270.8 E(): 9.4e-08%2C 28.8%25 identity in 222 aa overlap. Weak similarity to some transcriptional regulators. Contains probable helix-turn-helix motif at aa 39-60 (Score 1937%2C +5.78 SD). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene5350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5296 SCO5297 SCO5297 SC6G9.35c SC6G9.35c 5770657 5771510 + gene gene5351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5297 SCO5299 SCO5299 SC6G9.34 SC6G9.34 5771526 5772464 - hypothetical protein SC6G9.34%2C possible membrane protein%2C len: 312 aa%3B unknown function%2C similar to proteins from Mycobacterium leprae and Mycobacterium tuberculosis e.g. TR:O33063 (EMBL:Z99494) Mycobacterium leprae hypothetical protein (341 aa)%2C fasta scores%3B opt: 316 z-score: 387.1 E(): 3.1e-14%2C 27.1%25 identity in 255 aa overlap (divergent at C-terminus). Contains hydrophobic%2C possible membrane-spanning region gene gene5352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5299 SCO5300 SCO5300 SC6G9.33 SC6G9.33 5772612 5773118 - hypothetical protein SC6G9.33%2C hypothetical protein%2C len: 168 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Alternative start codon present at codon 6. Similar to TR:Q9A5F4 (EMBL:AE005918) Caulobacter crescentus hypothetical protein CC2496%2C 185 aa%3B fasta scores: opt: 573 Z-score: 686.8 E(): 1.3e-30%3B 52.532%25 identity in 158 aa overlap gene gene5353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5300 SCO5301 SCO5301 SC6G9.32 SC6G9.32 5773164 5774621 - penicillin-binding protein SC6G9.32%2C possible penicillin-binding protein%2C len: 485 aa%3B similar to many e.g. to the C-terminal end of SW:PBPC_BACSU (EMBL:D38161)%2C PbpC%2C Bacillus subtilis penicillin-binding protein 3 (668 aa)%2C fasta scores%3B opt: 422 z-score: 451.6 E(): 8e-18%2C 27.6%25 identity in 384 aa overlap. Similar to penicillin-binding proteins from mycobacteria e.g. TR:P71586 (EMBL:Z80233) Mycobacterium tuberculosis PpbA homologue (491 aa) (42.8%25 identity in 495 aa overlap). Contains a hydrophobic%2C possible membrane anchor at the N-terminus. Contains Pfam match to entry PF00905 Transpeptidase%2C Penicillin binding protein transpeptidase domain and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5301 SCO5302 SCO5302 SC6G9.31 SC6G9.31 5774638 5775978 - integral membrane cell-cycle protein SC6G9.31%2C probable integral membrane cell-cycle protein%2C len: 446 aa%3B similar to members of the ftsW (Escherichia coli cell division)/rodA (Escherichia coli cell shape)/spoVE (Bacillus subtilis spore formation) family e.g. SW:SP5E_BACSU (EMBL:X51419)%2C spoVE%2C Bacillus subtilis stage V sporulation protein E (366 aa)%2C fasta scores%3B opt: 461 z-score: 525.9 E(): 5.8e-22%2C 33.4%25 identity in 371 aa overlap. Highly similar to proteins from mycobacteria e.g. TR:FTSW_MYCLE (EMBL:Z70722)%2C ftsW%2C Mycobacterium leprae probable cell division protein (465 aa) (46.5%25 identity in 430 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE%2C Cell cycle protein gene gene5355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5302 SCO5303 SCO5303 SC6G9.30 SC6G9.30 5776055 5776522 - hypothetical protein SC6G9.30%2C possible membrane protein%2C len: 155 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains hydrophobic%2C possible membrane-spanning region near the N-terminus gene gene5356 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5303 SCO5304 SCO5304 SC6G9.29 SC6G9.29 5776630 5777874 - sensor-like histidine kinase SC6G9.29%2C possible sensor-like histidine kinase%2C len: 414 aa%3B similar to many sensor histidine kinases from two-component systems e.g. (EMBL:AJ13121)%2C CseC%2C S.coelicolor sensory histidine kinase of two-component system regulating sigE transcription (507 aa)%2C fasta scores%3B opt: 966 z-score: 1051.7 E(): 0%2C 44.3%25 identity in 429 aa overlap. This protein does not have an obvious response regulator companion. Similar to part of another lone sensor-like histidine kinase TR:O05890 (EMBL:Z95121)%2C Mycobacterium tuberculosis sensor-like histidine kinase (567 aa) (33.8%25 identity in 397 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam matches to entry PF00672 DUF5%2C Domain found in bacterial signal proteins and to entry PF00512 signal%2C Signal carboxyl-terminal domain. Contains possible hydrophobic membrane spanning regions gene gene5357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5304 SCO5305 SCO5305 SC6G9.28 SC6G9.28 5777871 5778689 - lipoprotein SC6G9.28%2C possible lipoprotein%2C len: 272 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5305 SCO5306 SCO5306 SC6G9.27 SC6G9.27 5778817 5779296 - protein phosphatase SC6G9.27%2C possible protein phosphatase%2C len: 159 aa%3B very weak similarity to eukaryotic tyrosine and dual-specificity protein phosphatases e.g. TR:O70275 (EMBL:AF035645) Mus musculus protein tyrosine phosphatase 4A3 (173 aa)%2C fasta scores%3B opt: 130 z-score: 173.4 E(): 0.025%2C 33.3%25 identity in 78 aa overlap. Alternative start codons are present at codons 12 and 17. Contains Pfam match to entry PF00782 DSPc%2C Dual specificity phosphatase%2C catalytic domain gene gene5359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5306 SCO5307 SCO5307 SC6G9.26c SC6G9.26c 5779410 5780234 + hypothetical protein SC6G9.26c%2C hypothetical protein%2C len: 274 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Alternative start codons are present at codons 8 and 14 gene gene5360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5307 SCO5308 SCO5308 SC6G9.25 SC6G9.25 5780326 5781207 - hypothetical protein SC6G9.25%2C conserved hypothetical protein%2C len: 293 aa%3B unknown function%2C similar to the N-terminal ends of hypothetical proteins from Mycobacterium tuberculosis e.g. TR:P95226 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical protein (397 aa)%2C fasta scores%3B opt: 534 z-score: 643.4 E(): 1.7e-28%2C 36.6%25 identity in 292 aa overlap and to the C-terminal end of TR:O34398 (EMBL:Z99110) Bacillus subtilis hypothetical protein (611 aa) (29.8%25 identity in 282 aa overlap). Also similar to S. coelicolor hypothetical protein SC4C6.19 (341 aa) (34.6%25 identity in 295 aa overlap) and (EMBL:AL033505)%2C SC1E6.07%2C S.coelicolor hypothetical protein (319 aa) (32.8%25 identity in 259 aa overlap). Alternative start codons are present at codons 4%2C 7%2C 12 and 20 gene gene5361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5308 SCO5309 SCO5309 SC6G9.24c SC6G9.24c 5781254 5782351 + hypothetical protein SC6G9.24c%2C conserved hypothetical protein%2C len: 365 aa%3B unknown function%2C similar to hypothetical proteins from Mycobacterium tuberculosis%2C Bacillus subtilis and Archaeoglobus fulgidus e.g. TR:O05866 (EMBL:Z95209) Mycobacterium tuberculosis hypothetical protein (273 aa)%2C fasta scores%3B opt: 648 z-score: 651.9 E(): 5.6e-29%2C 36.5%25 identity in 274 aa overlap. An alternative start codon is present as codon 4 gene gene5362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5309 SCO5310 SCO5310 SC6G9.23 SC6G9.23 5782374 5782937 - hypothetical protein SC6G9.23%2C hypothetical protein%2C len: 187 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference%2C amino acid composition and the presence of a possible RBS gene gene5363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5310 SCO5311 SCO5311 SC6G9.22 SC6G9.22 5783226 5783972 - hypothetical protein SC6G9.22%2C possible hypothetical protein%2C len: 248 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains possible N-terminal signal sequence gene gene5364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5311 SCO5312 SCO5312 SC6G9.21 SC6G9.21 5784136 5784570 - hypothetical protein SC6G9.21%2C conserved hypothetical protein%2C len: 144 aa%3B unknown function%2C similar to hypothetical proteins from Mycobacterium tuberculosis e.g. TR:O06553 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical protein (147 aa)%2C fasta scores%3B opt: 478 z-score: 561.4 E(): 6.1e-24%2C 55.7%25 identity in 140 aa overlap gene gene5365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5312 SCO5313 SCO5313 SC6G9.20 SC6G9.20 5784597 5785508 - hypothetical protein SC6G9.20%2C possible membrane protein%2C len: 303 aa%3B unknown function%2C C-terminal half shows weak similarity to the corresponding region of TR:O05859 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical protein (285 aa)%2C fasta scores%3B opt: 285 z-score: 275.6 E(): 5e-08%2C 31.4%25 identity in 277 aa overlap. Contains a hydrophobic%2C possible membrane-spanning region near the N-terminus. Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature gene gene5366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5313 SCO5314 SCO5314 SC6G9.19 SC6G9.19 5785753 5786088 - whiE protein VII SC6G9.19%2C whiE ORF VII%2C len: 111 aa%3B unknown function%2C whiE locus protein previously sequenced from S. coelicolor as SW:YW12_STRCO (EMBL:X55942) gene gene5367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5314 SCO5315 SCO5315 SC6G9.18 SC6G9.18 5786122 5786601 - polyketide cyclase SC6G9.18%2C polyketide cyclase%2C len: 159 aa%3B whiE locus polyketide cyclase previously sequenced from S. coelicolor as SW:CYPC_STRCO (EMBL:X55942) gene gene5368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5315 SCO5316 SCO5316 SC6G9.17 SC6G9.17 5786603 5786875 - acyl carrier protein SC6G9.17%2C acyl carrier protein%2C len 90 aa%3B whiE locus acyl carrier protein previously sequenced from S.coelicolor as SW:ACP_STRCO (EMBL:X55942). Contains Pfam match to entry PF00550 pp-binding%2C Phosphopantetheine attachment site and PS00012 Phosphopantetheine attachment site gene gene5369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5316 SCO5317 SCO5317 SC6G9.16 SC6G9.16 5786945 5788219 - polyketide beta-ketoacyl synthase beta SC6G9.16%2C polyketide beta-ketoacyl synthase beta%2C len: 424 aa%3B whiE locus polyketide beta-ketoacyl synthase beta previously sequenced from S. coelicolor as SW:KAS2_STRCO (EMBL:X55942). May form heterodimer with SW:KAS1_STRCO%2C SC6G9.15 in beta-ketoacyl synthase beta-ketoacyl synthase alpha. Similar to others from S.coelicolor e.g. TR:O54149 (EMBL:AL021409) probable 3-oxoacyl-[acyl-carrier-protein] synthase (407 aa) (34.6%25 identity in 405 aa overlap). Contains Pfam match to entry PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase gene gene5370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5317 SCO5318 SCO5318 SC6G9.15 SC6G9.15 5788216 5789487 - polyketide beta-ketoacyl synthase alpha SC6G9.15%2C polyketide beta-ketoacyl synthase alpha%2C len: 423 aa%3B whiE locus polyketide beta-ketoacyl synthase alpha previously sequenced from S. coelicolor as SW:KAS1_STRCO (EMBL:X55942). May form heterodimer with SW:KAS2_STRCO%2C SC6G9.16 beta-ketoacyl synthase beta. Similar to others from S.coelicolor e.g. TR:O54149 (EMBL:AL021409) probable 3-oxoacyl-[acyl-carrier-protein] synthase (407 aa) (39.1%25 identity in 419 aa overlap). Contains Pfam match to entry PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase and PS00606 Beta-ketoacyl synthases active site gene gene5371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5318 SCO5319 SCO5319 SC6G9.14 SC6G9.14 5789484 5789957 - whiE protein II SC6G9.14%2C whiE ORF II%2C len: 157 aa%3B unknown function%2C whiE locus protein previously sequenced from S. coelicolor as SW:WH16_STRCO (EMBL:X55942) gene gene5372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5319 SCO5320 SCO5320 SC6G9.13 SC6G9.13 5790104 5791297 - whiE protein I SC6G9.13%2C whiE ORF I%2C len: 397 aa%3B unknown function%2C whiE locus protein previously sequenced from S. coelicolor as SW:WH42_STRCO (EMBL:X55942) gene gene5373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5320 SCO5321 SCO5321 SC6G9.12c SC6G9.12c 5791641 5793524 + polyketide hydroxylase SC6G9.12c%2C polyketide hydroxylase%2C len: 627 aa%3B previously partially sequenced from S.coelicolor as SW:HYDL_STRCO (EMBL:X74213). Highly similar to SW:HYDL_STRHA (EMBL:L05390)%2C schC%2C Streptomyces halstedii polyketide hydroxylase involved in synthesis of a polyketide spore pigment (555 aa)%2C fasta scores%3B opt: 2290 z-score: 1755.0 E(): 0%2C 69.2%25 identity in 629 aa overlap. Also similar to many hydroxylases of substitued aromatic compounds. A notable difference between this sequence and its Streptomyces halstedii homologue is the presence of 12x GGP repeats starting at aa 413. Weakly similar to TR:O50491 (EMBL:AL020958) S.coelicolor possible monooxygenase (541 aa) (29.2%25 identity in 583 aa overlap). This feature is also absent from the other related hydroxylases. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. Contains possible hydrophobic membrane spanning region gene gene5374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5321 SCO5322 SCO5322 SC6G9.11c SC6G9.11c 5793601 5794470 + hypothetical protein SC6G9.11c%2C conserved hypothetical protein%2C len: 289 aa%3B unknown function%2C similar to TR:O53410 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical protein (285 aa)%2C fasta scores%3B opt: 556 z-score: 639.1 E(): 2.9e-28%2C 38.8%25 identity in 286 aa overlap gene gene5375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5322 SCO5323 SCO5323 SC6G9.10 SC6G9.10 5794528 5795022 - transcription regulator AsnC SC6G9.10%2C probable Asn-C family transcriptional regulator%2C len: 164 aa%3B similar to many e.g. TR:P94329 (EMBL:U85623)%2C Lrp%2C Bradyrhizobium japonicum leucine-responsive regulatory protein (153 aa)%2C fasta scores%3B opt: 211 z-score: 261.3 E(): 3.2e-07%2C 30.8%25 identity in 143 aa overlap. Similar to others from S.coelicolor e.g. (EMBL:AL049628)%2C SCE94.12c%2C LrpA%2C probable AsnC-family transcriptional regulator (150 aa) (28.0%25 identity in 150 aa overlap). Contains probable helix-turn-helix motif at aa 24-45 (Score 1012%2C +2.63 SD). Contains Pfam match to entry PF01037 ASNC_trans_reg%2C AsnC family gene gene5376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5323 SCO5324 SCO5324 SC6G9.09c SC6G9.09c 5795157 5795837 + oxidoreductase SC6G9.09c%2C possible oxidoreductase%2C len: 226 aa%3B weak similarity to SW:NOX_THETH (EMBL:X60110) Thermus aquaticus NADH dehydrogenase (205 aa)%2C fasta scores%3B opt: 159 z-score: 201.0 E(): 0.00073%2C 26.7%25 identity in 191 aa overlap. Similar to TR:O75989 (EMBL:AL031010) Homo sapiens hypothetical protein (184 aa) (40.0%25 identity in 185 aa overlap) and to part of SW:YKH5_CAEEL (EMBL:L23649) Caenorhabditis elegans hypothetical protein (359 aa) (28.6%25 identity in 185 aa overlap). Weak similarity to SW:NOX_THETH (EMBL:X60110) Thermus aquaticus NADH dehydrogenase (205 aa) (26.7%25 identity in 191 aa overlap). Contains Pfam match to entry PF00881 Nitroreductase%2C Nitroreductase family gene gene5377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5324 SCO5325 SCO5325 SC6G9.08c SC6G9.08c 5796053 5796373 + hypothetical protein SC6G9.08c%2C hypothetical protein%2C len: 106 aa%3B unknown function%2C improbable CD suggested by GC frameplot. C-terminus is proline-rich and overlaps with hypothetical CDS on opposite strand gene gene5378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5325 SCO5326 SCO5326 SC6G9.07 SC6G9.07 5796324 5796578 - hypothetical protein SC6G9.07%2C hypothetical protein%2C len: 54 aa%3B unknown function%2C possible CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Similar to part of (EMBL:AL049573)%2C SCE39.23%2C S.coelicolor hypothetical protein (88 aa)%2C fasta scores%3B opt: 165 z-score: 222.7 E(): 4.4e-05%2C 46.7%25 identity in 60 aa overlap. C-terminus overlaps with hypothetical CDS on opposite strand gene gene5379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5326 SCO5327 SCO5327 SC6G9.06c SC6G9.06c 5796736 5797479 + transposase SC6G9.06c%2C possible transposase%2C len: 247 aa%3B similar to TR:Q48342 (EMBL:M28508) Streptomyces lividans ORFA from insertion element IS493 (254 aa)%2C fasta scores%3B opt: 585 z-score: 725.3 E(): 4.5e-33%2C 45.0%25 identity in 220 aa overlap. Contains probable helix-turn-helix motif at aa 49-70 (Score 1540%2C +4.43 SD) gene gene5380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5327 SCO5328 SCO5328 SC6G9.05 SC6G9.05 5797829 5798573 - gene gene5382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5328 SCO5329 SCO5329 SC6G9.04c SC6G9.04c 5798773 5800470 + hypothetical protein SC6G9.04c%2C hypothetical protein%2C len: 565 aa%3B similar to TR:O34810 (EMBL:AE000641) Helicobacter pylori hypothetical protein (578 aa)%2C fasta scores%3B opt: 391 z-score: 464.1 E(): 1.6e-18%2C 23.6%25 identity in 525 aa overlap and to several other hypothetical proteins from the same organism%2C with the highest similarity toward the N-terminus. The coding sequence has unusually low %25G+C content gene gene5383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5329 SCO5330 SCO5330 SC6G9.03c SC6G9.03c 5800933 5801835 + hypothetical protein SC6G9.03c%2C hypothetical protein%2C len: 300 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene5384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5330 SCO5331 SCO5331 SC6G9.02 SC6G9.02 5801998 5805600 - DNA methylase SC6G9.02%2C possible DNA methylase%2C len: 1200 aa%3B highly similar to TR:O86561 (EMBL:AL031350) (71.5%25 identity in 867 aa overlap) and TR:O86674 (EMBL:AL031371) (90.8%25 identity in 370 aa overlap) which together constitute a single hypothetical protein split across the join between S.coelicolor cosmids 1F2 and 4G2. It has very weak similarity to DNA methylases%2C which combined with the presence of a DNA methylases signature and possible DNA-binding region (helix-turn-helix) provides circumstantial evidence of DNA-methylase function. The central third of the CDS is relatively AT rich. Contains probable helix-turn-helix motif at aa 38-59 (Score 1036%2C +2.72 SD). Contains PS00092 N-6 Adenine-specific DNA methylases signature gene gene5385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5331 SCO5332 SCO5332 SC6G9.01c SC6G9.01c 5805823 5807334 + hypothetical protein SCBAC5H2.01%2C unknown (fragment)%2C len: >33 aa~SC6G9.01c%2C hypothetical protein%2C partial CDS%2C len: >409 aa%3B unknown function%2C possible CDS suggested by positional base preference and amino acid composition. The coding sequence has unusually low %25G+C content. Alternative start codons are present at codons 9 and 27 gene gene5386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5332 SCO5333 SCO5333 SCBAC5H2.02c SCBAC5H2.02c 5807420 5808325 - hypothetical protein SCBAC5H2.02c%2C conserved hypothetical protein%2C len: 301 aa%3B similar to TR:Q9RU61 (EMBL:AE001997) Deinococcus radiodurans conserved hypothetical protein DR1533%2C 299 aa%3B fasta scores: opt: 496 z-score: 583.0 E(): 6.7e-25%3B 46.3%25 identity in 298 aa overlap. Contains Pfam match to entry PF02182 G9a%2C Domain of unknown function gene gene5387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5333 SCO5334 SCO5334 SCBAC5H2.03c SCBAC5H2.03c 5808844 5809158 - hypothetical protein SCBAC5H2.03c%2C unknown%2C len: 104 aa. Highly hydrophilic. High content in arginine and serine amino acid residues gene gene5388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5334 SCO5335 SCO5335 SCBAC5H2.04 SCBAC5H2.04 5809171 5809434 + hypothetical protein SCBAC5H2.04%2C unknown%2C len: 87 aa gene gene5389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5335 SCO5336 SCO5336 SCBAC5H2.05c SCBAC5H2.05c 5809422 5809892 - mutT-like protein SCBAC5H2.05c%2C possible mutT-like protein%2C len: 156 aa%3B similar to plasmid borne SW:MUTT_STRAM (EMBL:Z19590) Streptomyces ambofaciens plasmid pSAM2 mutT-like protein ORF154%2C 154 aa%3B fasta scores: opt: 182 z-score: 232.1 E(): 2.4e-05%3B 32.7%25 identity in 153 aa overlap. Contains Pfam match to entry PF00293 mutT%2C MutT-like domain%2C and match to Prosite entry PS00893 mutT domain signature gene gene5390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5336 SCO5337 SCO5337 SCBAC5H2.06c SCBAC5H2.06c 5809921 5810652 - hypothetical protein SCBAC5H2.06c%2C unknown%2C len: 243 aa gene gene5391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5337 SCO5338 SCO5338 pra2 pra2 5810810 5811163 + regulatory protein SCBAC5H2.07%2C pra2%2C probable regulatory protein%2C len: 117 aa%3B highly similar to plasmid borne TR:Q53733 (EMBL:Z34987) Streptomyces ambofaciens pSAM2 regulatory protein Pra%2C 116 aa%3B fasta scores: opt: 535 z-score: 695.9 E(): 3.5e-31%3B 72.9%25 identity in 118 aa overlap and to TR:Q9X8D1 (EMBL:AL049573) Streptomyces coelicolor Pra%2C regulatory protein SCE39.08c%2C 118 aa%3B fasta scores: opt: 565 z-score: 733.8 E(): 0%3B 76.3%25 identity in 118 aa overlap gene gene5392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5338 SCO5339 SCO5339 SCBAC5H2.08 SCBAC5H2.08 5811167 5812522 + plasmid transfer protein SCBAC5H2.08%2C traSA2%2C probable plasmid transfer protein%2C len: 451 aa%3B highly similar to TR:Q9X8D0 (EMBL:AL049573) Streptomyces coelicolor plasmid transfer protein TraSA%2C 451 aa%3B fasta scores: opt: 2539 z-score: 2830.9 E(): 0%3B 84.3%25 identity in 451 aa overlap%2C to plasmid borne SW:TRSA_STRAM (EMBL:Z19593) Streptomyces ambofaciens transfer protein TraSA%2C 415 aa%3B fasta scores: opt: 2345 z-score: 2615.4 E(): 0%3B 84.8%25 identity in 415 aa overlap and to TR:O86766 (EMBL:AL031035) Streptomyces coelicolor traSA:integrase fusion protein SC6A9.34%2C 768 aa%3B fasta scores: opt: 2326 z-score: 2253.5 E(): 0%3B 85.4%25 identity in 405 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE%2C FtsK/SpoIIIE family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5339 SCO5340 SCO5340 SCBAC5H2.09 SCBAC5H2.09 5812543 5812740 + hypothetical protein SCBAC5H2.09%2C unknown%2C len: 65 aa gene gene5394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5340 SCO5341 SCO5341 SCBAC5H2.10 SCBAC5H2.10 5812762 5813430 + SpdA2 protein SCBAC5H2.10%2C spdA2 protein%2C len: 222 aa%3B highly similar to plasmid borne TR:Q07193 (EMBL:Z19593) Streptomyces ambofaciens probably involved in pSAM2 spreading (intramycelial transfer) SpdA protein%2C 224 aa%3B fasta scores: opt: 1086 z-score: 974.5 E(): 0%3B 74.9%25 identity in 223 aa overlap and to TR:Q9X8C9 (EMBL:AL049573) Streptomyces coelicolor SpdA protein%2C 217 aa%3B fasta scores: opt: 1079 z-score: 968.6 E(): 0%3B 75.5%25 identity in 220 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5341 SCO5342 SCO5342 SCBAC5H2.11 SCBAC5H2.11 5813452 5813643 + SpdB2 protein SCBAC5H2.11%2C spdB2 protein%2C len: 63 aa%3B highly similar to plasmid borne TR:Q07194 (EMBL:Z19593) Streptomyces ambofaciens probably involved in pSAM2 spreading (intramycelial transfer) SpdB protein%2C 58 aa%3B fasta scores: opt: 354 z-score: 518.8 E(): 2.5e-21%3B 82.3%25 identity in 62 aa overlap and to TR:Q9X8C8 (EMBL:AL049573) Streptomyces coelicolor SpdB protein%2C 53 aa%3B fasta scores: opt: 350 z-score: 513.7 E(): 4.9e-21%3B 90.4%25 identity in 52 aa overlap gene gene5396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5342 SCO5343 SCO5343 SCBAC5H2.12 SCBAC5H2.12 5813654 5813809 + SpdC2 protein SCBAC5H2.12%2C spdC2 protein%2C len: 51 aa%3B identical to plasmid borne TR:Q07195 (EMBL:AJ005260) Streptomyces ambofaciens probably involved in pSAM2 spreading (intramycelial transfer) SpdC%2C 51 aa and highly similar to TR:Q9X8C7 (EMBL:AL049573) Streptomyces coelicolor SpdC protein%2C 51 aa%3B fasta scores: opt: 280 z-score: 413.2 E(): 1.9e-15%3B 78.4%25 identity in 51 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5343 SCO5344 SCO5344 SCBAC5H2.13 SCBAC5H2.13 5813822 5814145 + SpdD2 protein SCBAC5H2.13%2C spdD2 protein%2C len: 107 aa%3B highly similar to plasmid borne TR:Q07196 (EMBL:AJ005260) Streptomyces ambofaciens probably involved in pSAM2 spreading (intramycelial transfer) SpdD protein%2C 104 aa%3B fasta scores: opt: 517 z-score: 454.5 E(): 9.7e-18%3B 74.5%25 identity in 106 aa overlap and to TR:Q9X8C6 (EMBL:AL049573) Streptomyces coelicolor SpdD protein%2C 105 aa%3B fasta scores: opt: 485 z-score: 428.0 E(): 2.9e-16%3B 70.6%25 identity in 109 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5344 SCO5345 SCO5345 SCBAC5H2.14 SCBAC5H2.14 5814235 5814786 + hypothetical protein SCBAC5H2.14%2C conserved hypothetical protein%2C len: 183 aa%3B highly similar to plasmid borne TR:CAA06454 (EMBL:AJ005260) Streptomyces ambofaciens unknown ORF183%2C 183 aa%3B fasta scores: opt: 1018 z-score: 1225.2 E(): 0%3B 81.4%25 identity in 183 aa overlap. Contains Pfam match to entry PF00990 DUF9%2C Domain of unknown function DUF9 and a TTA leucine codon%2C possible target for bldA regulation gene gene5399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5345 SCO5346 SCO5346 SCBAC5H2.15 SCBAC5H2.15 5814872 5815057 + hypothetical protein SCBAC5H2.15%2C unknown%2C len: 61 aa gene gene5400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5346 SCO5347 SCO5347 repSA2 repSA2 5815050 5816414 + replication initiation protein SCBAC5H2.16%2C repSA2%2C replication initiation protein%2C len: 454 aa%3B highly similar to plasmid borne SW:REPS_STRAM (EMBL:Z19594) Streptomyces ambofaciens replication initiation protein repSA%2C 459 aa%3B fasta scores: opt: 2806 z-score: 3256.0 E(): 0%3B 90.8%25 identity in 446 aa overlap and to TR:Q9X8C5 (EMBL:AL049573) Streptomyces coelicolor replication initiation protein repSA%2C 466 aa%3B fasta scores: opt: 2759 z-score: 3201.4 E(): 0%3B 88.1%25 identity in 453 aa overlap gene gene5401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5347 SCO5348 SCO5348 SCBAC5H2.17 SCBAC5H2.17 5816416 5816601 + excisionase SCBAC5H2.17%2C possible excisionase%2C len: 61 aa%3B similar to TR:Q53965 (EMBL:X71358) Streptomyces coelicolor plasmid SLP1 DNA for xis and int genes%2C Xis%2C 61 aa%3B fasta scores: opt: 148 z-score: 233.1 E(): 2.1e-05%3B 38.3%25 identity in 60 aa overlap gene gene5402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5348 SCO5349 SCO5349 SCBAC5H2.18 SCBAC5H2.18 5816598 5817971 + integrase SCBAC5H2.18%2C probable integrase%2C len: 457 aa%3B similar to TR:CAC08268 (EMBL:AL392146) Streptomyces coelicolor integrase Int%2C 455 aa%3B fasta scores: opt: 1486 z-score: 1774.0 E(): 0%3B 50.3%25 identity in 455 aa overlap and to plasmid borne TR:Q53966 (EMBL:X71358) Streptomyces coelicolor plasmid SLP1 DNA for xis and int genes%2C Int%2C 455 aa%3B fasta scores: opt: 1486 z-score: 1774.0 E(): 0%3B 50.3%25 identity in 455 aa overlap gene gene5403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5349 SCO5350 SCO5350 SCBAC5H2.19 SCBAC5H2.19 5818003 5818548 + hypothetical protein SCBAC5H2.19%2C unknown%2C len: 181 aa. Contains two TTA leucine codons%2C possible targets for bldA regulation gene gene5404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5350 SCO5351 SCO5351 SCBAC5H2.20 SCBAC5H2.20 5818975 5819478 + regulatory protein SCBAC5H2.20%2C possible regulatory protein%2C len: 167 aa%3B similar to the N-terminal domain of several regulatory proteins%2C e.g. TR:Q9X6C1 (EMBL:AF135389) Tolypothrix PCC7601 DNA binding response regulator RpaA%2C 247 aa%3B fasta scores: opt: 332 z-score: 343.7 E(): 1.4e-11%3B 42.0%25 identity in 119 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain gene gene5406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5351 SCO5352 SCO5352 SCBAC5H2.21 SCBAC5H2.21 5819600 5820643 + arginyl tRNA synthetase SCBAC5H2.21%2C possible arginyl tRNA synthetase%2C len: 347 aa%3B similar to SW:SYR_BRELA (EMBL:Z21501) Brevibacterium lactofermentum arginyl tRNA synthetase (EC 6.1.1.19) ArgS%2C 550 aa%3B fasta scores (to C-terminal region): opt: 234 z-score: 260.2 E(): 6.4e-07%3B 36.0%25 identity in 161 aa overlap and blastp scores (to N-terminal region): Score %3D 182 (64.1 bits)%2C Expect %3D 1.2e-28%2C Sum P(2) %3D 1.2e-28%3B Identities %3D 45/116 (38%25)%2C Positives %3D 65/116 (56%25) and similar to SW:SYR_MYCTU (EMBL:Z73419) Mycobacterium tuberculosis arginyl t-RNA synthetase (EC 6.1.1.19) ArgS or MTCY373.12%2C 550 aa%3B fasta scores: opt: 216 z-score: 240.5 E(): 8.1e-06%3B 28.1%25 identity in 363 aa overlap gene gene5407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5352 SCO5353 SCO5353 lysA lysA 5820662 5822053 + diaminopimelate decarboxylase SCBAC5H2.22%2C lysA%2C diaminopimelate decarboxylase%2C len: 463 aa%3B highly similar to SW:DCDA_CORGL (EMBL:X07563) Corynebacterium glutamicum diaminopimelate decarboxylase (EC 4.1.1.20) LysA%2C 445 aa%3B fasta scores: opt: 1503 z-score: 1722.5 E(): 0%3B 51.0%25 identity in 443 aa overlap. Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC%2C Pyridoxal-dependent decarboxylase and matches to Prosite entries PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site and PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2 gene gene5408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5353 SCO5354 SCO5354 SCBAC5H2.23 SCBAC5H2.23 5822215 5823504 + homoserine dehydrogenase catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine gene gene5409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5354 SCO5355 SCO5355 SCBAC5H2.24 SCBAC5H2.24 5823511 5824569 + threonine synthase catalyzes the formation of L-threonine from O-phospho-L-homoserine gene gene5410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5355 SCO5356 SCO5356 SCBAC5H2.25 SCBAC5H2.25 5824855 5825784 + homoserine kinase catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate gene gene5411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5356 SCO5357 SCO5357 rho rho 5826214 5828298 + transcription termination factor Rho An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes gene gene5412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5357 SCO5358 SCO5358 2SC6G5.02 2SC6G5.02 5828747 5829895 + hypothetical protein 2SC6G5.02%2C possible membrane protein%2C len: 382 aa%3B regions similar to many of undefined function e.g. TR:O68907 (EMBL:AF058302) FrnA from Streptomyces roseofulvus (770 aa) fasta scores%3B opt: 747%2C z-score: 793.3%2C E(): 0%2C 40.8%25 identity in 304 aa overlap. Also similar to others from Streptomyces coelicolor e.g. TR:O69850 (EMBL:AL023702) transcriptional regulator (366 aa) fasta scores%3B opt: 1200%2C z-score: 1277.4%2C E(): 0%2C 52.2%25 identity in 356 aa overlap. Contains possible membrane-spanning hydrophobic regions gene gene5413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5358 SCO5359 SCO5359 rpmE rpmE 5830020 5830244 + 50S ribosomal protein L31 RpmE%3B there appears to be two types of ribosomal proteins L31 in bacterial genomes%3B some contain a CxxC motif while others do not%3B Bacillus subtilis has both types%3B the proteins in this cluster have the CXXC motif%3B RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth%3B expression of ytiA is controlled by a zinc-specific transcriptional repressor%3B RpmE contains one zinc ion and a CxxC motif is responsible for this binding%3B forms an RNP particle along with proteins L5%2C L18%2C and L25 and 5S rRNA%3B found crosslinked to L2 and L25 and EF-G%3B may be near the peptidyltransferase site of the 50S ribosome gene gene5414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5359 SCO5360 SCO5360 prfA prfA 5830353 5831429 + peptide chain release factor 1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1%3B this protein is similar to release factor 2 gene gene5415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5360 SCO5361 SCO5361 2SC6G5.05 2SC6G5.05 5831498 5832343 + methylase 2SC6G5.05%2C probable methylase%2C len: 281aa%3B similar to many eg. TR:P72542 (EMBL:U60417) PapM from Streptomyces pristinaespiralis which catalyses the two successive N-methylation steps of 4-amino-L-phenylalanine leading to DMPAPA via 4-methylamino-L-phenylalanine (292 aa) fasta scores%3B opt: 723%2C z-score: 865.6%2C E(): 0%2C 44.5%25 identity in 265 aa overlap. Contains Prosite match to PS00092 N-6 Adenine-specific DNA methylases signature and a possible membrane-spanning hydrophobic region. gene gene5416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5361 SCO5362 SCO5362 2SC6G5.06 2SC6G5.06 5832394 5833041 + hypothetical protein 2SC6G5.06%2C conserved hypothetical protein%2C len: 281aa%3B similar to many eg. SW:Q10618 (YD01_MYCTU) hypothetical protein from Mycobacterium tuberculosis (217 aa) fasta scores%3B opt: 777%2C z-score: 892.2%2C E(): 0%2C 56.7%25 identity in 208 aa overlap. Contains Pfam match to entry PF01300 Sua5_yciO_yrdC%2C SUA5/yciO/yrdC family and Prosite match to PS01147 SUA5/yciO/yrdC family signature. gene gene5417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5362 SCO5363 SCO5363 2SC6G5.07 2SC6G5.07 5833218 5833718 + hypothetical protein 2SC6G5.07%2C unknown%2C len: 166 aa gene gene5418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5363 SCO5364 SCO5364 2SC6G5.08 2SC6G5.08 5833806 5835062 + serine hydroxymethyltransferase 2SC6G5.08%2C glyA3%2C serine hydroxymethyltransferase (EC 2.1.2.1)%2C len: 418 aa%3B strongly similar to many e.g. SW:P00477 (GLYA_ECOLI) serine hydroxymethyltransferase from Escherichia coli (417 aa) fasta scores%3B opt: 1164%2C z-score: 1265.0%2C E(): 0%2C 47.9%25 identity in 407 aa overlap. Contains Pfam match to entry PF00464 SHMT%2C Serine hydroxymethyltransferase. Also similar to two others from Streptomyces coelicolor%3B SC2A11.04c (SW:O86565 (GLYA_STRCO)) and SC5G8.05 (TR:CAB89056 (EMBL:AL353872)). gene gene5419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5364 SCO5365 SCO5365 2SC6G5.09 2SC6G5.09 5835206 5836510 + transferase 2SC6G5.09%2C possible transferase%2C len: 434 aa%3B similar to many transferases e.g. SW:Q10606 (RFE_MYCTU) UDP-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-) from Mycobacterium tuberculosis (404 aa)%3B fasta scores%3B opt: 965%2C z-score: 1122.5%2C E(): 0%2C 43.7%25 identity in 375 aa overlap and SW:Q03521 (MRAY_BACSU) phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (324 aa) from Bacillus subtilis%3B fasta scores%3B opt: 252%2C z-score: 297.6%2C E(): 4.2e-09%2C 26.9%25 identity in 342 aa overlap. Contains Pfam match to entry PF00953 Glycos_transf_4%2C Glycosyl transferase. gene gene5420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5365 SCO5366 SCO5366 2SC6G5.10 2SC6G5.10 5836773 5837207 + ATP synthase I 2SC6G5.10%2C atpI%2C ATP synthase I%2C len: 144 aa%3B identical to SW:P50015 (ATPZ_STRLI) ATP synthase I from Streptomyces lividans (144 aa). Contains possible membrane-spanning hydrophobic regions gene gene5421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5366 SCO5367 SCO5367 2SC6G5.11 2SC6G5.11 5837433 5838254 + F0F1 ATP synthase subunit A Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 gene gene5422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5367 SCO5368 SCO5368 2SC6G5.12 2SC6G5.12 5838330 5838560 + ATP synthase subunit C 2SC6G5.12%2C atpE%2C ATP synthase C chain (EC 3.6.1.34)%2C len: 76aa%3B strongly similar to many eg. SW:P12409 (ATPL_ANASP) ATP synthase C chain from Anabaena sp. (strain PCC 7120) (81 aa) fasta scores%3B opt: 194%2C z-score: 262.9%2C E(): 3.6e-07%2C 43.8%25 identity in 73 aa overlap. Identical to SW:P50014 (ATPL_STRLI) ATP synthase C chain from Streptomyces lividans. Contains Pfam match to entry PF00137 ATP-synt_C%2C ATP synthase subunit C%2C Prosite match to PS00605 ATP synthase c subunit signature and possible membrane-spanning hydrophobic regions. gene gene5423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5368 SCO5369 SCO5369 2SC6G5.13 2SC6G5.13 5838602 5839156 + F0F1 ATP synthase subunit B Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. gene gene5424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5369 SCO5370 SCO5370 2SC6G5.14 2SC6G5.14 5839153 5839977 + F0F1 ATP synthase subunit delta produces ATP from ADP in the presence of a proton gradient across the membrane%3B the delta subunit is part of the catalytic core of the ATP synthase complex gene gene5425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5370 SCO5371 SCO5371 2SC6G5.15 2SC6G5.15 5840171 5841760 + F0F1 ATP synthase subunit alpha produces ATP from ADP in the presence of a proton gradient across the membrane%3B the alpha chain is a catalytic subunit gene gene5426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5371 SCO5372 SCO5372 2SC6G5.16 2SC6G5.16 5841782 5842699 + F0F1 ATP synthase subunit gamma Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit gene gene5427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5372 SCO5373 SCO5373 2SC6G5.17 2SC6G5.17 5842699 5844135 + F0F1 ATP synthase subunit beta Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit gene gene5428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5373 SCO5374 SCO5374 atpC atpC 5844267 5844641 + F0F1 ATP synthase subunit epsilon produces ATP from ADP in the presence of a proton gradient across the membrane%3B the epsilon subunit is part of the catalytic core of the ATP synthase complex gene gene5429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5374 SCO5375 SCO5375 2SC6G5.19 2SC6G5.19 5844778 5845233 + hypothetical protein 2SC6G5.19%2C possible hypothetical protein%2C len: 151aa%3B similar to SW:Q10620 (YD12_MYCTU) hypothetical protein from Mycobacterium tuberculosis (147 aa) fasta scores%3B opt: 282%2C z-score: 358.4%2C E(): 1.7e-12%2C 38.9%25 identity in 144 aa overlap. Contains possible N-terminal signal sequence peptide gene gene5430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5375 SCO5376 SCO5376 2SC6G5.20c 2SC6G5.20c 5845252 5847081 - chitinase C 2SC6G5.20c%2C chiC%2C chitinase C (EC 3.2.1.14) ( hypothetical protein)%2C len: 609aa%3B previously sequenced as TR:Q9Z9M8 (EMBL:AB017010). Strongly similar to others from Streptomyces spp. e.g. SW:P11220 (CHIT_STRPL) chitinase 63 precursor from Streptomyces plicatus (610 aa) fasta scores%3B opt: 3997%2C z-score: 3833.9%2C E(): 0%2C 95.1%25 identity in 611 aa overlap. Contains Pfam match to entry PF00704 Glyco_hydro_18%2C Glycosyl hydrolases family 18%2C Pfam match to entry PF00041 fn3%2C Fibronectin type III domain%2C Pfam match to entry PF00553 CBD_2%2C Cellulose binding domain%2C Prosite match to PS00561 Cellulose-binding domain%2C bacterial type%2C Prosite match to PS01095 Chitinases family 18 active site and Prosite match to PS00018 EF-hand calcium-binding domain. Also contains a possible non-cleavable N-terminal signal sequence. gene gene5431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5376 SCO5377 SCO5377 2SC6G5.21c 2SC6G5.21c 5847229 5847870 - chitinase two-component response regulator 2SC6G5.21c%2C chiR%2C chitinase two-component response regulator%2C len: 213 aa%3B previously sequenced as TR:Q9Z677 (EMBL:AF102271). Similar to many others eg. TR:Q9RHU6 (EMBL:AB016841) response regulator from chitinase regulatory system in Streptomyces thermoviolaceus (213 aa) fasta scores%3B opt: 956%2C z-score: 1085.4%2C E(): 0%2C 77.0%25 identity in 213 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature and a helix-turn-helix motif (residue 169-190). gene gene5432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5377 SCO5378 SCO5378 2SC6G5.22c 2SC6G5.22c 5847867 5849063 - chitinase two-component sensor kinase 2SC6G5.22c%2C chiS%2C chitinase two-component sensor kinase%2C len: 398aa%3B previously sequenced as TR:Q9Z678 (EMBL:AF102271). Similar to many others eg. TR:Q9RHU7 (EMBL:AB016841) sensor kinase from chitinase regulatory system in Streptomyces thermoviolaceus (448 aa) fasta scores%3B opt: 1663%2C z-score: 1797.1%2C E(): 0%2C 67.4%25 identity in 396 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene5433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5378 SCO5379 SCO5379 2SC6G5.23 2SC6G5.23 5849216 5849800 + hypothetical protein 2SC6G5.23%2C possible membrane protein%2C len: 194aa%3B similar to TR:O31780 (EMBL:Z99112) hypothetical protein from Bacillus subtilis (185 aa) fasta scores%3B opt: 399%2C z-score: 492.4%2C E(): 5.9e-20%2C 34.3%25 identity in 178 aa overlap. Contains possible membrane-spanning hydrophobic regions. Also contains Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature but no similarity to any other regulators. gene gene5434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5379 SCO5380 SCO5380 2SC6G5.24 2SC6G5.24 5849797 5849985 + hypothetical protein 2SC6G5.24%2C possible membrane protein%2C len: 62aa%3B weakly similar to TR:Q9XA75 (EMBL:AL096822) membrane protein from Streptomyces coelicolor (83 aa) fasta scores%3B opt:82%2C z-score: 135.0%2C E(): 4.7%2C 37.0%25 identity in 54 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene5435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5380 SCO5381 SCO5381 2SC6G5.25c 2SC6G5.25c 5850114 5850686 - hypothetical protein 2SC6G5.25c%2C conserved hypothetical protein%2C len: 190aa%3B similar to many eg. SW:Q10622 (Y02Y_MYCTU) hypothetical protein from Mycobacterium tuberculosis (193 aa) fasta scores%3B opt: 800%2C z-score: 984.0%2C E(): 0%2C 65.6%25 identity in 189 aa overlap. Contains Pfam match to entry PF01923 DUF80%2C Protein of unknown function. gene gene5436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5381 SCO5382 SCO5382 2SC6G5.26c 2SC6G5.26c 5850700 5851449 - ABC transporter 2SC6G5.26c%2C possible ABC transporter%2C integral membrane subunit%2C len: 249aa%3B similar to TR:Q53627 (EMBL:U43537) membrane protein involved in mithramycin resistance from Streptomyces argillaceus (233 aa) fasta scores%3B opt: 704%2C z-score: 811.8%2C E(): 0%2C 47.1%25 identity in 227 aa overlap. Contains Pfam match to entry PF01061 ABC2_membrane%2C ABC-2 type transporter and possible membrane-spanning hydrophobic regions. gene gene5437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5382 SCO5383 SCO5383 2SC6G5.27c 2SC6G5.27c 5851470 5852252 - ABC transporter ATP-binding protein 2SC6G5.27c%2C possible ABC transporter%2C ATP-binding subunit%2C len: 260aa%3B similar to many eg. TR:Q53626 (EMBL:U43537) ATP-binding protein involved in mithramycin resistance from Streptomyces argillaceus (320 aa) fasta scores%3B opt: 901%2C z-score: 998.1%2C E():0%2C 59.6%25 identity in 225 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature. gene gene5438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5383 SCO5384 SCO5384 2SC6G5.28 2SC6G5.28 5852346 5852987 + TetR family transcriptional regulator 2SC6G5.28%2C possible tetR-family transcriptional regulator%2C len: 213 aa%3B similar to many proposed transcriptional regulators e.g. TR:CAB88457 (EMBL:AL353815) tetR-family transcriptional regulator from Streptomyces coelicolor (215 aa) fasta scores%3B opt: 370%2C z-score: 461.9%2C E(): 3e-18%2C 36.8%25 identity in 209 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a helix-turn-helix motif (residue 33-54). gene gene5439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5384 SCO5385 SCO5385 2SC6G5.29 2SC6G5.29 5853124 5853972 + 3-hydroxybutyryl-CoA dehydrogenase 2SC6G5.29%2C possible 3-hydroxybutyryl-coA dehydrogenase%2C len: 282 aa%3B similar to many eg. SW:P52041 (HBD_CLOAB) 3-hydroxybutyryl-coA dehydrogenase from Clostridium acetobutylicum (282 aa) fasta scores%3B opt: 806%2C z-score: 947.0%2C E(): 0%2C 44.6%25 identity in 280 aa overlap. Contains Pfam match to entry PF00725 3HCDH%2C 3-hydroxyacyl-CoA dehydrogenase and Prosite match to PS00067 3-hydroxyacyl-CoA dehydrogenase signature. gene gene5440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5385 SCO5386 SCO5386 2SC6G5.30 2SC6G5.30 5854163 5854486 + anti-sigma factor antagonist 2SC6G5.30%2C possible anti-sigma factor antagonist%2C len: 107aa%3B similar to many eg. SW:P95842 (RSBV_STAAU) anti-sigma B factor antagonist from Staphylococcus aureus (108 aa) fasta scores%3B opt: 164%2C z-score: 226.7%2C E(): 3.7e-05%2C 30.9%25 identity in 94 aa overlap. Contains Pfam match to entry PF01740 SpoIIAA%2C SpoIIAA family. gene gene5441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5386 SCO5387 SCO5387 2SC6G5.31 2SC6G5.31 5854720 5857344 + hypothetical protein 2SC6G5.31%2C unknown%2C len: 874 aa gene gene5442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5387 SCO5388 SCO5388 2SC6G5.32c 2SC6G5.32c 5857445 5858200 - hypothetical protein 2SC6G5.32c%2C conserved hypothetical protein%2C len: 251 aa%3B similar to many eg. SW:Q10634 (Y036_MYCTU) hypothetical protein from Mycobacterium tuberculosis (226 aa) fasta scores%3B opt: 1161%2C z-score: 1353.2%2C E(): 0%2C 76.1%25 identity in 226 aa overlap. Contains Pfam match to entry PF01939 DUF91%2C Protein of unknown function. gene gene5443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5388 SCO5389 SCO5389 2SC6G5.33 2SC6G5.33 5858397 5858789 + hypothetical protein 2SC6G5.33%2C unknown%2C len: 130 aa gene gene5444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5389 SCO5390 SCO5390 2SC6G5.34c 2SC6G5.34c 5858868 5859896 - alkanal monooxygenase 2SC6G5.34c%2C possible alkanal monooxygenase (luciferase)%2C len: 342aa%3B similar to luciferase alpha chain from many eg. SW:P19839 (LXA1_PHOLU) alkanal monooxygenase alpha chain (EC 1.14.14.3) (bacterial luciferase alpha chain) from Photorhabdus luminescens (Xenorhabdus luminescens) (360 aa) fasta scores%3B opt: 442%2C z-score: 520.4%2C E(): 1.6e-21%2C 30.1%25 identity in 359 aa overlap. Contains Pfam match to entry PF00296 bac_luciferase%2C Bacterial luciferase. gene gene5445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5390 SCO5391 SCO5391 2SC6G5.35 2SC6G5.35 5860153 5860485 + ATP/GTP-binding protein 2SC6G5.35%2C possible ATP/GTP-binding protein%2C doubtful CDS%2C len: 110aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene5446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5391 SCO5392 SCO5392 2SC6G5.36c 2SC6G5.36c 5860494 5861363 - ABC transporter 2SC6G5.36c%2C possible ABC transporter integral membrane subunit%2C len: 289aa%3B similar to many membrane proteins of eg. TR:O86630 (EMBL:AL031155) probable integral membrane protein from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 424%2C z-score: 479.6%2C E(): 3.1e-19%2C 33.9%25 identity in 274 aa overlap. Contains possible membrane-spanning hydrophobic regions and lies immediately downstream of a possible ABC transporter ATP-binding subunit. gene gene5447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5392 SCO5393 SCO5393 2SC6G5.37c 2SC6G5.37c 5861360 5862631 - ABC transporter ATP-binding protein 2SC6G5.37c%2C possible ABC transporter ATP-binding subunit%2C len: 423aa%3B similar to many eg. TR:Q9S6T6 (EMBL:AL035654) ABC transporter ATP-binding protein from Streptomyces coelicolor (317 aa) fasta scores%3B opt: 1132%2C z-score: 771.9%2C E(): 0%2C 60.2%25 identity in 309 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene5448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5393 SCO5394 SCO5394 2SC6G5.38c 2SC6G5.38c 5862780 5863556 - ABC transporter 2SC6G5.38c%2C possible ABC transporter integral membrane subunit%2C len: 256aa%3B similar to many membrane proteins of eg. TR:O86630 (EMBL:AL031155) probable integral membrane protein from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 504%2C z-score: 572.6%2C E(): 2e-24%2C 37.6%25 identity in 258 aa overlap.. Contains possible membrane-spanning hydrophobic regions and lies immediately downstream of a possible ABC transporter ATP-binding subunit. gene gene5449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5394 SCO5395 SCO5395 2SC6G5.39c 2SC6G5.39c 5863553 5864593 - ABC transporter ATP-binding protein 2SC6G5.39c%2C possible ABC transporter ATP-binding subunit%2C len: 346aa%3B similar to many eg. TR:Q9S6T6 (EMBL:AL035654) ABC transporter ATP-binding protein from Streptomyces coelicolor (317 aa) fasta scores%3B opt: 1180%2C z-score: 1223.8%2C E(): 0%2C 58.5%25 identity in 316 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene5450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5395 SCO5396 SCO5396 2SC6G5.40c 2SC6G5.40c 5864669 5865601 - cellulose-binding protein 2SC6G5.40c%2C probable cellulose-binding protein%2C len: 310aa%3B strongly similar to TR: (EMBL:) AbpS avicel-binding protein from Streptomyces reticuli (311 aa) fasta scores%3B opt: 1777%2C z-score: 1598.0%2C E(): 0%2C 93.2%25 identity in 311 aa overlap. Contains a possible membrane-spanning hydrophobic region close to the N-terminus and possible coiled-coil regions throughout. gene gene5451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5396 SCO5397 SCO5397 SC8F4.01c SC8F4.01c 5865809 5869789 - large Ala/Glu-rich protein SC8F4.01c%2C large Ala/Glu-rich protein%2C len: 1326 aa%3B hydrophilic with strong potential for coiled-coil structure throughout. gene gene5452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5397 SCO5398 SCO5398 SC8F4.02c SC8F4.02c 5870023 5870463 - hypothetical protein SC8F4.02c%2C conserved hypothetical protein%2C len: 146aa%3B similar to several of undefined function eg. TR:O28065 (EMBL:AE000952) conserved hypothetical protein from Archaeoglobus fulgidus (131 aa) fasta scores%3B opt: 346 z-score: 449.3 E(): 1.3e-17 40.4%25 identity in 136 aa overlap. gene gene5453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5398 SCO5399 SCO5399 SC8F4.03 SC8F4.03 5870613 5871818 + acetyl-CoA acetyltransferase Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase%2C catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation%3B in Rhizobia and Ralstonia is involved in PHB biosynthesis gene gene5454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5399 SCO5400 SCO5400 SC8F4.04 SC8F4.04 5871855 5872811 + transport system kinase SC8F4.04%2C possible transport system kinase%2C len: 318 aa%3B similar to SW:P27254 (ARGK_ECOLI) LAO/AO transport system kinase from Escherichia coli. Thought to phosphorylate the LAO/AO periplasmic binding proteins. (331 aa) fasta scores%3B opt: 562%2C z-score: 600.4%2C E(): 4.9e-26%2C35.1%25 identity in 271 aa overlap. gene gene5455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5400 SCO5401 SCO5401 SC8F4.05 SC8F4.05 5873153 5874457 + hypothetical protein SC8F4.05%2C probable integral membrane protein%2C len: 434aa%3B similar to many proposed transport proteins eg. TR:CAB59494 (EMBL:AL132648) transport proteins from Streptomyces coelicolor (405 aa) fasta scores%3B opt: 529%2C z-score: 545.1%2C E(): 5.9e-23%2C 35.2%25 identity in 392 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene5456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5401 SCO5402 SCO5402 SC8F4.06c SC8F4.06c 5874400 5875173 - hypothetical protein SC8F4.06c%2C Asp-rich hydrophilic protein ( membrane protein)%2C len: 257 aa. Contains possible hydrophobic membrane spanning region gene gene5457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5402 SCO5403 SCO5403 SC8F4.07 SC8F4.07 5875298 5875966 + two-component system response regulator SC8F4.07%2C probable two-component system response regulator%2C len: 222 aa%3B similar to many e.g. SW:Q02540 (COPR_PSESM) CopR transcriptional activator protein from Pseudomonas syringae (pv. tomato) (227 aa) fasta scores%3B opt: 621%2C z-score: 735.4%2C E(): 0%2C 45.7%25 identity in 223 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal. gene gene5458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5403 SCO5404 SCO5404 SC8F4.08 SC8F4.08 5875963 5877399 + two-component sensor kinase SC8F4.08%2C probable two-component sensor kinase%2C len: 478 aa%3B similar to many proposed two-component sensor kinases eg. SW:P18392 (RSTB_ECOLI) sensor protein RstB from Escherichia coli (433 aa) fasta scores%3B opt: 379%2C z-score: 410.8%2C E(): 1.8e-15%2C 35.6%25 identity in 239 aa overlap. Contains Pfam match to entry PF00672 DUF5%2C Domain found in bacterial signal proteins and Pfam match to entry PF00512 signal%2C Histidine kinase. gene gene5459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5404 SCO5405 SCO5405 SC8F4.09c SC8F4.09c 5877408 5877884 - transcriptional regulator SC8F4.09c%2C probable transcriptional regulator%2C len: 158 aa%3B similar to many e.g. TR:Q9X5U1 (EMBL:AF127374) from Streptomyces lavendulae (163 aa) fasta scores%3B opt: 382%2C z-score: 481.8%2C E(): 2e-19%2C 43.4%25 identity in 152 aa overlap and SW:P42195 (PECS_ERWCH) regulatory protein PecS from Erwinia chrysanthemi fasta scores%3B opt: 172%2C z-score: 225.1%2C E(): 3.9e-05%2C 28.7%25 identity in 136 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and helix-turn-helix motif Score 1270 (+3.51 SD) in ID at residue 60. gene gene5460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5405 SCO5406 SCO5406 SC8F4.10c SC8F4.10c 5877986 5878762 - hypothetical protein SC8F4.10c%2C hypothetical protein%2C len: 258 aa%3B similar to TR:AAF10203 (EMBL:AE001920) hypothetical protein from Deinococcus radiodurans (254 aa) fasta scores%3B opt: 157%2C z-score: 174.0%2C E(): 0.028%2C 27.8%25 identity in 245 aa overlap. Also weakly similar to the neighbouring hypothetical CDSs SC8F4.11c and SC8F4.12c. gene gene5461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5406 SCO5407 SCO5407 SC8F4.11c SC8F4.11c 5878759 5879418 - hypothetical protein SC8F4.11c%2C hypothetical protein%2C len: 219 aa%3B weakly similar to many e.g. TR:AAF10203 (EMBL:AE00192) hypothetical protein from Deinococcus radiodurans (254 aa) fasta scores%3B opt: 388%2C z-score: 453.5%2C E(): 7.5e-18%2C 36.9%25 identity in 214 aa overlap. Also weakly similar to the neighbouring hypothetical CDSs SC8F4.10c and SC8F4.12c gene gene5462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5407 SCO5408 SCO5408 SC8F4.12c SC8F4.12c 5879411 5880130 - hypothetical protein SC8F4.12c%2C hypothetical protein%2C len: 239 aa%3B weakly similar to many e.g. TR:AAF10203 (EMBL:AE00192) hypothetical protein from Deinococcus radiodurans (254 aa) fasta scores%3B opt: 441%2C z-score: 528.2%2C E(): 5.1e-22%2C 33.2%25 identity in 202 aa overlap. Also weakly similar to the neighbouring hypothetical CDSs SC8F4.10c and SC8F4.11c gene gene5463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5408 SCO5409 SCO5409 SC8F4.13 SC8F4.13 5880228 5880572 + hypothetical protein SC8F4.13%2C membrane protein%2C len: 114 aa%3B similar to TR:O31485 (EMBL:Z99106) hypothetical protein from Bacillus subtilis (96 aa) fasta scores%3B opt: 179%2C z-score: 259.7%2C E(): 4.7e-07%2C 37.4%25 identity in 91 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5409 SCO5410 SCO5410 SC8F4.14c SC8F4.14c 5880887 5881012 - hypothetical protein SC8F4.14c%2C hypothetical protein%2C improbable%2C len: 41 aa gene gene5465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5410 SCO5411 SCO5411 SC8F4.15c SC8F4.15c 5881074 5882480 - integrase/recombinase SC8F4.15c%2C possible integrase/recombinase%2C len: 468aa%3B similar to many eg. TR:Q38184 (EMBL:X85213) integrase from Bacteriophage TP901-1 (485 aa) fasta scores%3B opt: 281%2C z-score: 318.4%2C E(): 2.5e-10%2C 26.9%25 identity in 428 aa overlap. Contains Pfam match to entry PF00239 recombinase%2C Site-specific recombinases and 2x tta Leu codon%2C possible target for bldA regulation. gene gene5466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5411 SCO5412 SCO5412 SC8F4.16 SC8F4.16 5882513 5882656 + hypothetical protein SC8F4.16%2C hypothetical protein%2C len: 47 aa%3B similar to SW:O07734 (YC20_MYCTU) hypothetical protein from Mycobacterium tuberculosis (102 aa) fasta scores%3B opt: 193%2C z-score: 304.2%2C E(): 1.5e-09%2C 71.1%25 identity in 45 aa overlap. gene gene5467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5412 SCO5413 SCO5413 SC8F4.17 SC8F4.17 5882733 5883242 + MarR-transcriptional regulator SC8F4.17%2C possible transcriptional regulator%2C len: 169 aa%3B similar to many proposed transcriptional regulators e.g. TR:CAB62730 (EMBL:AL133423) MarR-family transcriptional regulator from Streptomyces coelicolor (151 aa) fasta scores%3B opt: 184%2C z-score: 242.7%2C E(): 4.1e-06%2C 35.1%25 identity in 111 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family. gene gene5468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5413 SCO5414 SCO5414 SC8F4.18 SC8F4.18 5883333 5883662 + hypothetical protein SC8F4.18%2C membrane protein%2C len: 109 aa%3B previously sequenced therefore identical to TR:Q9X948 (EMBL:AJ237976). Also similar to SW:Z75555 (Y076_MYCTU) hypothetical protein from Mycobacterium tuberculosis (120 aa) fasta scores%3B opt: 248%2C z-score: 330.5%2C E(): 5.3e-11%2C 37.5%25 identity in 96 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5414 SCO5415 SCO5415 icmA icmA 5883756 5885456 + isobutyryl-CoA mutase A SC8F4.19%2C icmA%2C isobutyryl-CoA mutase A%2C len: 566 aa%3B previously sequenced and characterised as TR:Q9X949 (EMBL:AJ237976). Contains Pfam match to entry PF01642 MM_CoA_mutase%2C Methylmalonyl-CoA mutase. gene gene5470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5415 SCO5416 SCO5416 SC8F4.20c SC8F4.20c 5885486 5886499 - transcriptional regulator SC8F4.20c%2C probable transcriptional regulator%2C len: 337 aa%3B previously partially sequenced therefore identical to TR:Q9X950 (EMBL:AJ237976). Similar to many proposed transcriptional regulators eg. TR:CAB61299 (EMBL:AL132991) AraC-family transcriptional regulator from Streptomyces coelicolor (311 aa) fasta scores%3B opt: 859%2C z-score: 986.2%2C E(): 0%2C 47.8%25 identity in 312 aa overlap. Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family gene gene5471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5416 SCO5417 SCO5417 SC8F4.21 SC8F4.21 5886533 5887552 + zinc-binding oxidoreductase SC8F4.21%2C possible zinc-binding oxidoreductase%2C len: 339aa%3B similar to many proposed oxidoreductases eg. TR:O85702 (EMBL:AF072709) oxidoreductase from Streptomyces lividans (313 aa) fasta scores%3B opt: 1311%2C z-score: 1369.8%2C E(): 0%2C 66.1%25 identity in 310 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and Prosite match to PS01162 Quinone oxidoreductase / zeta-crystallin signature. gene gene5472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5417 SCO5418 SCO5418 SC8F4.22c SC8F4.22c 5887579 5888283 - transcriptional regulator SC8F4.22c%2C possible transcriptional regulator%2C len: 234aa%3B similar to many eg. TR:Q54288 (EMBL:X86780) regulator of antibiotic transport complexes from Streptomyces hygroscopicus (204 aa) fasta scores%3B opt: 284%2C z-score: 301.4%2C E(): 2.2e-09%2C 31.3%25 identity in 211 aa overlap. Contains helix-turn-helix motif Score 1083 (+2.88 SD) in ID at residue 38. gene gene5473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5418 SCO5419 SCO5419 SC8F4.23 SC8F4.23 5888587 5889543 + thioredoxin SC8F4.23%2C trxA4%2C possible thioredoxin%2C len: 318aa%3B similar to many e.g. SW:P00275 (THI1_CORNE) thioredoxin C-1 from Corynebacterium nephridii (105 aa) fasta scores%3B opt: 297%2C z-score: 317.6%2C E(): 2.8e-10%2C 44.3%25 identity in 97 aa overlap. Contains Pfam match to entry PF00085 thiored%2C Thioredoxin and Prosite match to PS00194 Thioredoxin family active site. gene gene5474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5419 SCO5420 SCO5420 SC8F4.24 SC8F4.24 5890196 5890843 + cholesterol esterase SC8F4.24%2C che%2C cholesterol esterase%2C len: 215aa%3B strongly similar to TR:Q53425 (EMBL:S71532) che%2C cholesterol esterase from Streptomyces lavendulae (227 aa) fasta scores%3B opt: 632%2C z-score: 735.9%2C E(): 0%2C 51.5%25 identity in 231 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5420 SCO5421 SCO5421 SC8F4.25 SC8F4.25 5890960 5891517 + hypothetical protein SC8F4.25%2C possible integral membrane protein%2C len: 185 aa. Contains possible hydrophobic membrane spanning regions gene gene5476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5421 SCO5422 SCO5422 SC8F4.26 SC8F4.26 5891522 5892892 + hypothetical protein SC8F4.26%2C hypothetical hydrophilic protein%2C len: 456 aa%3B contains possible coiled-coil region around residue 250 gene gene5477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5422 SCO5423 SCO5423 pyk2 pyk2 5892975 5894405 - pyruvate kinase SC8F4.27c%2C pyk2%2C pyruvate kinase%2C len: 476 aa%3B strongly similar to many e.g. SW:Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores%3B opt: 1693%2C z-score: 1907.7%2C E(): 0%2C 55.3%25 identity in 474 aa overlap and TRNEW:CAB52070 (EMBL:AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores%3B opt: 2185%2C z-score: 2461.2%2C E(): 0%2C 69.3%25 identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK%2C Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature. gene gene5478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5423 SCO5424 SCO5424 ackA ackA 5894480 5895703 - acetate kinase AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation%3B utilizes magnesium and ATP%3B also involved in conversion of acetate to aceyl-CoA gene gene5479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5424 SCO5425 SCO5425 pta pta 5895700 5897793 - phosphate acetyltransferase catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate%3B when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate gene gene5480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5425 SCO5426 SCO5426 pfkA2 pfkA2 5897944 5898969 + 6-phosphofructokinase catalyzes the formation of D-fructose 1%2C6-bisphosphate from D-fructose 6-phosphate in glycolysis gene gene5481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5426 SCO5427 SCO5427 SC6A11.03c SC6A11.03c 5898979 5899692 - hypothetical protein SC6A11.03c%2C unknown%2C len: 237 aa%3B no significant database similarities gene gene5482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5427 SCO5428 SCO5428 SC6A11.04c SC6A11.04c 5899804 5900694 - integral membrane transport protein SC6A11.04c%2C possible integral membrane transport protein%2C len: 296aa%3B similar to many proposed transport proteins e.g. TR:Q9X9Y6(EMBL:AL096743) integral membrane transport protein from Streptomyces coelicolor (298 aa) fasta scores: opt: 515%2C z-score: 609.9%2C E(): 1.5e-26%2C 33.9%25 identity in 295 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C Prosite matches to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible membrane-spanning hydrophobic regions gene gene5483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5428 SCO5429 SCO5429 SC6A11.05c SC6A11.05c 5900696 5901637 - integral membrane transport protein SC6A11.05c%2C possible integral membrane transport protein%2C len: 313 aa%3B similar to many proposed transport proteins e.g. TRNEW:CAB55533(EMBL:AL117322) integral membrane transport protein from Streptomyces coelicolor (317 aa) fasta scores%3B opt: 561%2C z-score: 649.2%2C E(): 9.4e-29%2C 34.4%25 identity in 314 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible membrane-spanning hydrophobic regions gene gene5484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5429 SCO5430 SCO5430 SC6A11.06c SC6A11.06c 5901634 5903010 - extracellular solute-binding lipoprotein SC6A11.06c%2C possible extracellular solute-binding lipoprotein%2C len: 458 aa%3B similar to many proposed solute-binding proteins e.g. TR:P72397 (EMBL:Y07706) maltose-binding protein from Streptomyces coelicolor (423 aa) fasta scores%3B opt: 284%2C z-score: 316.1%2C E(): 3.4e-10%2C 29.1%25 identity in 443 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein%2C Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal sequence gene gene5485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5430 SCO5431 SCO5431 SC6A11.07c SC6A11.07c 5903536 5904399 - nucleosidase SC6A11.07c%2C possible nucleosidase%2C len: 287 aa%3B similar to many e.g. SW:P24247 (PFS_ECOLI) MTA/SAH nucleosidase (P46) from Escherichia coli (232 aa) fasta scores: opt: 211%2C z-score: 251.7%2C E(): 1.3e-06%2C 27.1%25 identity in 210 aa overlap. Contains Pfam match to entry PF01048 PNP_UDP_1%2C Phosphorylase family (which includes some nucleosidases) and possible N-terminal signal sequence gene gene5486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5431 SCO5432 SCO5432 SC6A11.08 SC6A11.08 5904427 5904966 + hypothetical protein SC6A11.08%2C possible integral membrane protein%2C len: 179 aa%3B no significant database similarities. Contains possible membrane-spanning hydrophobic regions gene gene5487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5432 SCO5433 SCO5433 SC6A11.09 SC6A11.09 5905174 5907459 + AfsR-like regulator SC6A11.09%2C possible AfsR-like regulator%2C len: 816 aa%3B similar to others from Streptomyces spp. e.g. SW:P25941 (AFSR_STRCO) regulatory protein AfsR from Streptomyces coelicolor (993 aa) fasta scores: opt: 490%2C z-score: 458.0%2C E(): 4.2e-18%2C 33.7%25 identity in 656 aa overlap. Note that this protein contains a Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) but no helix-turn-helix motifs gene gene5488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5433 SCO5434 SCO5434 SC6A11.10c SC6A11.10c 5907344 5908036 - two-component response regulator SC6A11.10c%2C possible two-component response regulator%2C len: 230 aa%3B similar to many e.g. SW:Q54149 (DPIA_ECOLI) transcriptional regulatory protein DpiA from Escherichia coli (226 aa) fasta scores: opt: 393%2C z-score: 440.6%2C E(): 3.9e-17%2C 33.8%25 identity in 222 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and a helix-turn-helix motif score 1515 (+4.35 SD) in ID at residue 179 gene gene5489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5434 SCO5435 SCO5435 SC6A11.11c SC6A11.11c 5908033 5909691 - two-component sensor kinase SC6A11.11c%2C possible two-component sensor kinase%2C len: 552 aa%3B similar to many eg. SW:P39272 (DCUS_ECOLI) sensor protein DcuS from Escherichia coli (543 aa) fasta scores%3B opt: 764%2C z-score: 809.1%2C E(): 0%2C 29.3%25 identity in 540 aa overlap. Contains Pfam match to entry PF00512 signal%2C Histidine kinase and possible membrane-spanning hydrophobic regions gene gene5490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5435 SCO5436 SCO5436 SC6A11.12 SC6A11.12 5909846 5911246 + sodium:dicarboxylate symporter SC6A11.12%2C possible sodium:dicarboxylate symporter%2C len: 466 aa%3B similar to many e.g. SW:P50334 (DCTA_SALTY) C4-dicarboxylate transport protein from Salmonella typhimurium (428 aa) fasta scores: opt: 1320%2C z-score: 1451.6%2C E(): 0%2C 48.9%25 identity in 419 aa overlap. Contains Pfam match to entry PF00375 SDF%2C Sodium:dicarboxylate symporter family gene gene5491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5436 SCO5437 SCO5437 SC6A11.13 SC6A11.13 5911410 5911808 + MerR family transcriptional regulator SC6A11.13%2C possible MerR-family transcriptional regulator%2C len: 132 aa%3B similar to many e.g. TR:Q9X5V4 (EMBL:AF127795) heavy metal regulator HmrR from Rhizobium leguminosarum (biovar viciae) (129 aa) fasta scores%3B opt: 228%2C z-score: 295.1%2C E(): 5e-09%2C 35.7%25 identity in 129 aa overlap. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and possible helix-turn-helix motif score 1747 (+5.14 SD) in ID at residue 1 gene gene5492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5437 SCO5438 SCO5438 SC6A11.14 SC6A11.14 5911820 5912134 + thioredoxin SC6A11.14%2C trxA2%2C thioredoxin%2C len: 104 aa%3B similar to many e.g. SW:P52230 (THIO_STRCO) thioredoxin TrxA from Streptomyces coelicolor (110 aa) fasta scores: opt: 360%2C z-score: 470.8%2C E(): 8.2e-19%2C 47.5%25 identity in 101 aa overlap. Contains Pfam match to entry PF00085 thiored%2C Thioredoxin and Prosite match to PS00194 Thioredoxin family active site gene gene5493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5438 SCO5439 SCO5439 SC6A11.15 SC6A11.15 5912270 5914537 + hypothetical protein SC6A11.15%2C hypothetical protein%2C len: 755 aa%3B similar to TR:O32215 (EMBL:Z99121) hypothetical protein from Bacillus subtilis (774 aa) fasta scores: opt: 323%2C z-score: 361.2%2C E(): 1e-12%2C 23.5%25 identity in 763 aa overlap gene gene5494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5439 SCO5440 SCO5440 glgBI glgBI 5914595 5916919 - glycogen branching protein catalyzes the transfer of a segment of a 1%2C4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain gene gene5495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5440 SCO5441 SCO5441 pep2A pep2A 5916960 5918354 - hypothetical protein SC6A11.17c%2C pep2A%2C hypothetical protein%2C len: 464 aa%3B previously sequenced as TR:O54204 (EMBL:AJ001205) gene gene5496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5441 SCO5442 SCO5442 SC6A11.18c SC6A11.18c 5918375 5920075 - trehalose synthase SC6A11.18c%2C possible trehalose synthase%2C len: 566 aa%3B previously sequenced as TR:O54203 (EMBL:AJ001205) Streptomyces coelicolor trehalose synthase. Also similar to many others e.g. SW:Q99040 (DEXB_STRMU) glucan 1%2C6-alpha-glucosidase DexB from Streptococcus mutans (536 aa) fasta scores: opt: 867%2C z-score: 1015.8%2C E(): 0%2C 32.2%25 identity in 522 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene5497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5442 SCO5443 SCO5443 pep1A pep1A 5920072 5922099 - alpha-amylase SC6A11.19c%2C pep1A%2C possible alpha-amylase%2C len: 675 aa%3B previously sequenced as TR:O54202 (EMBL:AJ001205). Also similar to TRNEW:AAF07898 (EMBL:AF172946) glucanase GlgE from Mycobacterium smegmatis (697 aa) fasta scores%3B opt: 2199%2C z-score: 2484.5%2C E(): 0%2C 53.6%25 identity in 679 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene5498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5443 SCO5444 SCO5444 glgP glgP 5922464 5925088 + glycogen phosphorylase SC3D11.01%2C glgP%2C possible glycogen phosphorylase%2C len: >201aa%3B previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores%3B opt: 242%2C z-score: 283.2%2C E(): 2.3e-08%2C 30.9%25 identity in 194 aa overlap.~SC6A11.20%2C glgP%2C possible glycogen phosphorylase (fragment)%2C len: >705 aa%3B previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores%3B opt: 849%2C z-score: 972.3%2C E(): 0%2C 40.5%25 identity in 699 aa overlap. Contains Prosite match to PS00102 Phosphorylase pyridoxal-phosphate attachment site gene gene5499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5444 SCO5445 SCO5445 SC3D11.02c SC3D11.02c 5925132 5925698 - hypothetical protein SC3D11.02c%2C hypothetical protein%2C len: 188aa%3B previously sequenced as TR:Q9X945 (EMBL:AJ001205) and predicted as a 134 aa protein. Also similar to TR:O06198 (EMBL:Z95387) hypothetical protein from Mycobacterium tuberculosis (166 aa) fasta scores%3B opt: 407%2C z-score: 496.4%2C E(): 3.1e-20%2C 44.0%25 identity in 159 aa overlap gene gene5500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5445 SCO5446 SCO5446 SC3D11.03c SC3D11.03c 5925711 5927360 - hypothetical protein SC3D11.03c%2C probable neutral zinc metalloprotease%2C len: 549aa%3B similar to many eg. SW:P05806 (NPRE_BACCE) bacillolysin precursor (EC 3.4.24.28) from Bacillus cereus (566 aa) fasta scores%3B opt: 607%2C z-score: 636.5%2C E(): 4.8e-28%2C 34.7%25 identity in 596 aa overlap. Also similar to the neighbouring CDS SC3D11.04c fasta scores%3B opt: 2442%2C z-score: 2158.9%2C E(): 0%2C 69.7%25 identity in 544 aa overlap and TR:CAB69762 (EMBL:AL137187) metalloproteinase from Streptomyces coelicolor fasta scores%3B opt: 1290%2C z-score: 1143.7%2C E(): 0%2C 52.7%25 identity in 560 aa overlap. Contains Pfam match to entry PF01447 Peptidase_M4%2C Thermolysin family peptidase and Prosite match to PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Contains possible hydrophobic membrane spanning region gene gene5501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5446 SCO5447 SCO5447 SC3D11.04c SC3D11.04c 5927688 5929742 - neutral zinc metalloprotease SC3D11.04c%2C probable neutral zinc metalloprotease%2C len: 684aa%3B similar to many eg. SW:P43263 (NPRE_BACBR) bacillolysin precursor from Bacillus brevis (527 aa) fasta scores%3B opt: 648%2C z-score: 662.4%2C E(): 1.7e-29%2C 34.6%25 identity in 480 aa overlap. Also similar to the neighbouring CDS SC3D11.03c fasta scores%3B opt: 2442%2C z-score: 2055.1%2C E(): 0%2C 69.9%25 identity in 544 aa overlap and TR:CAB69762 (EMBL:AL137187) metalloproteinase from Streptomyces coelicolor fasta scores%3B opt: 1265%2C z-score: 1067.4%2C E(): 0%2C 50.2%25 identity in 560 aa overlap. Contains Pfam match to entry PF01447 Peptidase_M4%2C Thermolysin family peptidase and Prosite match to PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Contains possible hydrophobic membrane spanning region gene gene5502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5447 SCO5448 SCO5448 SC3D11.05c SC3D11.05c 5930034 5931785 - ABC transporter SC3D11.05c%2C probable ABC transporter%2C len: 583aa%3B similar to many eg. TR:Q54204 (EMBL:X89010) from the 5'-hydroxystreptomycin production/transport operon of Streptomyces glaucescens (591 aa) fasta scores%3B opt: 1687%2C z-score: 1814.2%2C E(): 0%2C 49.3%25 identity in 564 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene5503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5448 SCO5449 SCO5449 SC3D11.06c SC3D11.06c 5931782 5933599 - ABC transporter SC3D11.06c%2C probable ABC transporter%2C len: 605aa%3B similar to many eg. TR:Q54203 (EMBL:X89010) from the 5'-hydroxystreptomycin production/transport operon of Streptomyces glaucescens (584 aa) fasta scores%3B opt: 885%2C z-score: 878.4%2C E(): 0%2C 40.3%25 identity in 601 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region and Prosite match to PS00211 ABC transporters family signature. gene gene5504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5449 SCO5450 SCO5450 SC3D11.07c SC3D11.07c 5933596 5935479 - ABC transporter SC3D11.07c%2C probable ABC transporter%2C len: 627aa%3B similar to many eg. TRNEW:CAB66302 (EMBL:AL136519) ABC transporter%2C ATP-binding component from Streptomyces coelicolor (1243 aa) fasta scores%3B opt: 1238%2C z-score: 1250.8%2C E(): 0%2C 38.7%25 identity in 633 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region%2C Prosite match to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene5505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5450 SCO5451 SCO5451 SC3D11.08c SC3D11.08c 5935476 5937458 - ABC transporter SC3D11.08c%2C probable ABC transporter%2C len: 660aa%3B similar to many eg. TRNEW:CAB66302 (EMBL:AL136519) ABC transporter%2C ATP-binding component from Streptomyces coelicolor (1243 aa) fasta scores%3B opt: 682%2C z-score: 703.6%2C E(): 8.8e-32%2C 34.4%25 identity in 608 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C Pfam match to entry PF00664 ABC_membrane%2C ABC transporter transmembrane region%2C Prosite match to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). gene gene5506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5451 SCO5452 SCO5452 SC3D11.09 SC3D11.09 5937594 5938532 + ABC transporter ATP-binding protein SC3D11.09%2C probable ABC transporter%2C ATP-binding subunit%2C len: 312aa%3B similar to many eg. TR:Q9XAC8 (EMBL:AL096839) ABC transporter%2C ATP-binding subunit from Streptomyces coelicolor (307 aa) fasta scores%3B opt: 713%2C z-score: 795.0%2C E(): 0%2C 43.5%25 identity in 299 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. gene gene5507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5452 SCO5453 SCO5453 SC3D11.10 SC3D11.10 5938529 5939278 + hypothetical protein SC3D11.10%2C possible integral membrane protein%2C len: 249aa%3B similar to many proposed membrane proteins eg. TR:Q9XAC7 (EMBL:AL096839) integral membrane transport protein from Streptomyces coelicolor (269 aa) fasta scores%3B opt: 292%2C z-score: 325.6%2C E(): 1e-10%2C 29.8%25 identity in 245 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene5508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5453 SCO5454 SCO5454 SC3D11.11 SC3D11.11 5939275 5940603 + two-component system sensor kinase SC3D11.11%2C possible two-component system sensor kinase%2C len: 442 aa%3B similar to many e.g. TR:CAA74719 (EMBL:Y14336) histidine autokinase from Streptomyces reticuli (398 aa) fasta scores%3B opt: 519%2C z-score: 573.4%2C E(): 1.6e-24%2C 36.3%25 identity in 369 aa overlap and SW:M23558 (DEGS_BACSU) sensor protein DegS from Bacillus subtilis (385 aa) fasta scores%3B opt: 343%2C z-score: 381.0%2C E(): 8.2e-14%2C 31.7%25 identity in 221 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5454 SCO5455 SCO5455 SC3D11.12 SC3D11.12 5940593 5941267 + two-component system response regulator SC3D11.12%2C possible two-component system response regulator%2C len: 224 aa%3B similar to many proposed response regulators e.g. TRNEW:CAA74720 (EMBL:Y14336) response regulatory protein SenR from Streptomyces reticuli (217 aa) fasta scores%3B opt: 643%2C z-score: 725.3%2C E(): 5.5e-33%2C 53.8%25 identity in 208 aa overlap and SW:X13360 (NARL_ECOLI) nitrate/nitrite response regulator protein NarL from Escherichia coli (216 aa) fasta scores%3B opt: 512%2C z-score: 580.2%2C E(): 6.6e-25%2C 38.6%25 identity in 207 aa overlap. Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C Prosite match to PS00622 Bacterial regulatory proteins%2C luxR family signature and helix-turn-helix motif Score 1439 (+4.09 SD) in ID at residue 178. gene gene5510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5455 SCO5456 SCO5456 glgX2 glgX2 5941319 5943667 - glycosyl hydrolase SC3D11.13c%2C glgX2%2C possible glycosyl hydrolase ( hypothetical protein)%2C len: 782 aa%3B similar to many eg. TR:Q9X947 (EMBL:AJ001206) glycogen debranching enzyme from Streptomyces coelicolor (715 aa) fasta scores%3B opt: 2630%2C z-score: 2693.4%2C E(): 0%2C 58.5%25 identity in 725 aa overlap and SW:P15067 (GLGX_ECOLI) glycogen operon protein from Escherichia coli (657 aa) fasta scores%3B opt: 1608%2C z-score: 1647.7%2C E(): 0%2C 47.2%25 identity in 669 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase. Contains possible N-terminal region signal peptide sequence gene gene5511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5456 SCO5457 SCO5457 SC3D11.14 SC3D11.14 5943733 5944983 + lipoprotein SC3D11.14%2C possible lipoprotein%2C len: 416aa%3B similar to many eg. TR:O53223 (EMBL:AL021185) hypothetical protein from Mycobacterium tuberculosis (408 aa) fasta scores%3B opt: 737%2C z-score: 800.7%2C E(): 0%2C 32.9%25 identity in 413 aa overlap. Also similar to neighbouring CDS SC3D11.15 fasta scores%3B opt: 1348%2C z-score: 1271.2%2C E(): 0%2C 53.3%25 identity in 394 aa overlap. Contains possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5457 SCO5458 SCO5458 SC3D11.15 SC3D11.15 5945149 5946351 + lipoprotein SC3D11.15%2C possible lipoprotein%2C len: 400aa%3B similar to many eg. TR:Q9X811 (EMBL:AL049497) hypothetical protein from Streptomyces coelicolor (424 aa) fasta scores%3B opt: 755%2C z-score: 799.1%2C E(): 0%2C 33.0%25 identity in 409 aa overlap. Also similar to neighbouring CDS SC3D11.14 fasta scores%3B opt: 1348%2C z-score: 1211.8%2C E(): 0%2C 53.3%25 identity in 394 aa overlap. Contains possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5458 SCO5459 SCO5459 SC3D11.16 SC3D11.16 5946399 5947166 + enoyl-CoA hydratase SC3D11.16%2C probable enoyl-coA hydratase%2C len: 255aa%3B similar to many eg. SW:P52046 (CRT_CLOAB) 3-hydroxybutyryl-coa dehydratase from Clostridium acetobutylicum (261 aa) fasta scores%3B opt: 637%2C z-score: 725.4%2C E(): 5.4e-33%2C 43.4%25 identity in 249 aa overlap. Contains Pfam match to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family and Prosite match to PS00166 Enoyl-CoA hydratase/isomerase signature. gene gene5514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5459 SCO5460 SCO5460 SC3D11.17 SC3D11.17 5947312 5947974 + AbaA-like regulatory protein SC3D11.17%2C possible AbaA-like regulatory protein%2C len: 220 aa%3B similar to many from Streptomyces spp. e.g. TRNEW:AAD46514 (EMBL:AF145724) regulatory protein from Streptomyces albus (137 aa) fasta scores%3B opt: 258%2C z-score: 275.0%2C E(): 6.6e-08%2C 45.3%25 identity in 128 aa overlap and TR:Q53897 (EMBL:X60316) AbaA from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 226%2C z-score: 240.9%2C E(): 5.3e-06%2C 32.3%25 identity in 189 aa overlap. gene gene5515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5460 SCO5461 SCO5461 SC3D11.18 SC3D11.18 5948080 5948694 + hypothetical protein SC3D11.18%2C possible hypothetical protein%2C len: 204aa%3B contains a possible non-cleavable N-terminal signal sequence. gene gene5516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5461 SCO5462 SCO5462 SC3D11.19c SC3D11.19c 5948711 5949349 - hypothetical protein SC3D11.19c%2C unknown%2C len: 212 aa%3B contains a weak Pfam match over much of its length to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene5517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5462 SCO5463 SCO5463 SC3D11.20 SC3D11.20 5949398 5950312 + MerR family transcriptional regulator SC3D11.20%2C possible MerR-family transcriptional regulator%2C len: 304 aa%3B similar to many e.g. TRNEW:CAB56383 (EMBL:AL118515) MerR-family transcriptional regulator from Streptomyces coelicolor (319 aa) fasta scores%3B opt: 622%2C z-score: 719.6%2C E(): 1.2e-32%2C 41.3%25 identity in 310 aa overlap. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family gene gene5518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5463 SCO5464 SCO5464 SC3D11.21 SC3D11.21 5950361 5950573 + hypothetical protein SC3D11.21%2C possible calcium-binding protein%2C len: 70aa%3B similar to many eukaryotic calcium-binding proteins eg. TR:Q42470 (EMBL:D63153) calcium-binding protein from Brassica rapa (Turnip)%2C and Brassica napus (Rape) (79 aa) fasta scores%3B opt: 153%2C z-score: 214.7%2C E(): 0.00015%2C 45.3%25 identity in 64 aa overlap and SW:P02599 (CALM_DICDI) calmodulin from Dictyostelium discoideum (Slime mold) (151 aa) fasta scores%3B opt: 155%2C z-score: 213.0%2C E(): 0.00019%2C 43.3%25 identity in 60 aa overlap. Contains Pfam match to entry PF00036 efhand%2C EF hand and two Prosite matches to PS00018 EF-hand calcium-binding domain. gene gene5519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5464 SCO5465 SCO5465 SC3D11.22 SC3D11.22 5950745 5951407 + hypothetical protein SC3D11.22%2C unknown%2C len: 220aa%3B similar to TRNEW:CAB61931 (EMBL:AL133278) hypothetical protein from Streptomyces coelicolor (219 aa) fasta scores%3B opt: 519%2C z-score: 572.9%2C E(): 1.7e-24%2C 45.5%25 identity in 200 aa overlap and TR:O29370 (EMBL:AE001042) hypothetical protein from Archaeoglobus fulgidus fasta scores%3B opt: 181%2C z-score: 208.1%2C E(): 0.00035%2C 26.2%25 identity in 206 aa overlap. also to TR:Q98N90 (EMBL:AP002994) Rhizobium loti (Mesorhizobium loti) MLL0243 protein%2C 231 aa%3B fasta scores: opt: 789 Z-score: 849.5 E(): 1.1e-39%3B 56.164%25 identity in 219 aa overlap gene gene5520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5465 SCO5466 SCO5466 SC3D11.23c SC3D11.23c 5951416 5951973 - hydrolase SC3D11.23c%2C possible hydrolase%2C len: 185aa%3B similar to many eg. SW:P34020 (LYC_CLOAB) autolytic lysozyme from Clostridium acetobutylicum (324 aa) fasta scores%3B opt: 231%2C z-score: 295.8%2C E(): 4.6e-09%2C 29.3%25 identity in 188 aa overlap. gene gene5521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5466 SCO5467 SCO5467 SC2A11.01 SC2A11.01 5952154 5952888 + muramoyl-pentapeptide carboxypeptidase SC2A11.01%2C probable muramoyl-pentapeptide carboxypeptidase%2C partial CDS%2C len: 189 aa%3B highly similar to S. albus CBPM_STRAL muramoyl-pentapeptide carboxypeptidase precursor (EC 3.4.17.8) (255 aa)%2C fasta scores%3B opt: 955 z-score: 1605.0 E(): 0%2C 71.1%25 identity in 190 aa overlap~SC3D11.24%2C possible muramoyl-pentapeptide carboxypeptidase%2C partial CDS%2C len: >88aa%3B similar to the N-terminal region of SW:P00733 (CBPM_STRAL) muramoyl-pentapeptide carboxypeptidase from Streptomyces albus (255 aa) gene gene5522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5467 SCO5468 SCO5468 SC2A11.02c SC2A11.02c 5952943 5954361 - transmembrane transport protein SC2A11.02c%2C probable transmembrane transport protein%2C len: 472 aa%3B similar to many e.g. YHJE_ECOLI hypothetical metabolite transport protein (440 aa)%2C fasta scores%3B opt: 772 z-score: 1638.5 E(): 0%2C 56.7%25 identity in 441 aa overlap and SHIA_ECOLI shikimate transporter (438 aa)%2C fasta scores%3B opt: 553 z-score: 980.0 E(): 0%2C 34.6%25 identity in 437 aa overlap. Contains PS00216 Sugar transport proteins signature 1 and Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporters%2C score 183.10%2C E-value 4.4e-51 gene gene5523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5468 SCO5469 SCO5469 sdaA sdaA 5954478 5955845 - L-serine dehydratase SC2A11.03c%2C sdaA%2C probable L-serine dehydratase%2C len: 455 aa%3B highly similar to e.g. SDHL_ECOLI L-serine dehydratase 1 (EC 4.2.1.13) (454 aa)%2C fasta scores%3B opt: 1643 z-score: 1576.6 E(): 0%2C 55.6%25 identity in 459 aa overlap gene gene5524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5469 SCO5470 SCO5470 glyA glyA 5955947 5957209 - serine hydroxymethyltransferase catalyzes the reaction of glycine with 5%2C10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate gene gene5525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5470 SCO5471 SCO5471 gcvH gcvH 5957224 5957601 - glycine cleavage system protein H part of multienzyme complex composed of H%2C L%2C P%2C and T proteins which catalyzes oxidation of glycine to yield carbon dioxide%2C ammonia%2C 5%2C10-CH2-H4folate and a reduced pyridine nucleotide%3B protein H is involved in transfer of methylamine group from the P to T protein%3B covalently bound to a lipoyl cofactor gene gene5526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5471 SCO5472 SCO5472 gcvT gcvT 5957728 5958846 - glycine cleavage system aminomethyltransferase T catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate%2C causing the release of ammonia and the generation of reduced GcvH protein gene gene5527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5472 SCO5473 SCO5473 SC2A11.07 SC2A11.07 5959273 5959941 + ATP/GTP binding protein SC2A11.07%2C probable ATP/GTP binding protein%2C len: 222 aa%3B contains PS00017 ATP /GTP-binding site motif A (P-loop) gene gene5528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5473 SCO5474 SCO5474 SC2A11.08 SC2A11.08 5960021 5960788 + hypothetical protein SC2A11.08%2C unknown%2C len: 255 aa gene gene5529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5474 SCO5475 SCO5475 SC2A11.09 SC2A11.09 5960983 5961780 + hypothetical protein SC2A11.09%2C unknown%2C len: 265 aa gene gene5530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5475 SCO5476 SCO5476 SC2A11.10 SC2A11.10 5962095 5963102 + oligopeptide transport integral membrane protein SC2A11.10%2C probable oligopeptide transport integral membrane protein%2C len: 335 aa%3B similar to mnay e.g. APPC_BACSU oligopeptide transport permease appC (303 aa)%2C fasta scores%3B opt: 465 z-score: 1038.5 E(): 0%2C 41.4%25 identity in 309 aa overlap. Also similar to S. coelicolor TR:P72406 (EMBL:U68036) bldKA (335 aa)%2C fasta scores%3B opt: 912 z-score: 1192.3 E(): 0%2C 42.1%25 identity in 330 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature and Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 47.00%2C E-value 4.1e-10 gene gene5531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5476 SCO5477 SCO5477 SC2A11.11 SC2A11.11 5963174 5964976 + oligopeptide-binding lipoprotein SC2A11.11%2C probable oligopeptide-binding lipoprotein%2C len: 600 aa%3B similar to e.g. OPPA_BACSU oligopeptide-binding protein oppA precursor (545 aa)%2C fasta scores%3B opt: 401 z-score: 242.5 E(): 3e-06%2C 25.5%25 identity in 554 aa overlap Also similar to S. coelicolor TR:P72407 (EMBL:U68036) bldKB (602 aa)%2C fasta scores%3B opt: 702 z-score: 583.5 E(): 3e-25%2C 29.3%25 identity in 614 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C and Pfam match to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5%2C score 45.60%2C E-value 7.2e-11 gene gene5532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5477 SCO5478 SCO5478 SC2A11.12 SC2A11.12 5965085 5966083 + oligopeptide transport system integral membrane protein SC2A11.12%2C probable oligopeptide transport system integral membrane protein%2C len: 332 aa%3B similar to many e.g. OPPB_ECOLI oligopeptide transport system permease (306 aa)%2C fasta scores%3B opt: 568 z-score: 807.4 E(): 0%2C 35.0%25 identity in 337 aa overlap Also similar to S. coelicolor TR:P72408 (EMBL:U68036) bldKC (323 aa)%2C fasta scores%3B opt: 875 z-score: 1186.1 E(): 0 42.4%25 identity in 337 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature and Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 34.10%2C E-value 3.1e-06 gene gene5533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5478 SCO5479 SCO5479 SC2A11.13 SC2A11.13 5966080 5967177 + oligopeptide ABC transporter ATP-binding protein SC2A11.13%2C probable oligopeptide ABC transporter ATP-binding protein%2C len: 365 aa%3B similar to many e.g. OPPD_BACSU oligopeptide transport ATP-binding protein (336 aa)%2C fasta scores%3B opt: 1089 z-score: 1413.1 E(): 0%2C 52.3%25 identity in 323 aa overlap Also similar to S. coelicolor TR:P72409 (EMBL:U68036) bldKD (353 aa)%2C fasta scores%3B opt: 1396 z-score: 1731.9 E(): 0%2C 58.4%25 identity in 365 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 203.50%2C E-value 3.3e-57 gene gene5534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5479 SCO5480 SCO5480 SC2A11.14 SC2A11.14 5967174 5968664 + oligopeptide ABC transporter ATP-binding protein SC2A11.14%2C probable oligopeptide ABC transporter ATP-binding protein%2C len: 496 aa%3B similar to many e.g. APPF_BACSU oligopeptide transport ATP-binding protein (329 aa)%2C fasta scores%3B opt: 1284 z-score: 1056.3 E(): 0%2C 56.4%25 identity in 326 aa overlap Also similar to S. coelicolor TR:P72410 (EMBL:U68036) bldKE (284 aa)%2C fasta scores%3B opt: 1114 z-score: 1091.6 E(): 0%2C 59.3%25 identity in 280 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 202.90%2C E-value 4.8e-57. C-terminus contains 13 degenerate repeats of AS(D /S)DA gene gene5535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5480 SCO5481 SCO5481 SC2A11.15 SC2A11.15 5968742 5969401 + hypothetical protein SC2A11.15%2C probable integral membrane protein%2C len: 219 aa%3B similar to hypothetical proteins e.g. YADS_ECOLI (207 aa)%2C fasta scores%3B opt: 397 z-score: 543.4 E(): 5.2e-23%2C 36.7%25 identity in 196 aa overlap gene gene5536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5481 SCO5482 SCO5482 SC2A11.16 SC2A11.16 5969537 5970559 + hypothetical protein SC2A11.16%2C unknown%2C len: 340 aa%3B some similarity to M. tuberculosis hypothetical protein YV25_MYCTU MTCY20G9.25%2C Rv0499 (291 aa)%2C fasta scores%3B opt: 240 z-score: 316.7 E(): 2.2e-10%2C 28.9%25 identity in 270 aa overlap gene gene5537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5482 SCO5483 SCO5483 SC2A11.17c SC2A11.17c 5970588 5971214 - transcriptional regulator SC2A11.17c%2C probable transcriptional regulator%2C len: 208 aa%3B similar to members of the tetR family e.g. TCMR_STRGA tetracenomycin C transcriptional repressor (226 aa)%2C fasta scores%3B opt: 138 z-score: 224.5 E(): 3e-05%2C 26.5%25 identity in 155 aa overlap. Contains helix-turn-helix motif at aa 36-57 (Score 1332%2C +3.72 SD) and Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family%2C score 23.40%2C E-value 9.9e-05 gene gene5538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5483 SCO5484 SCO5484 SC2A11.18 SC2A11.18 5971342 5971509 + small hydrophobic membrane protein SC2A11.18%2C small hydrophobic membrane protein%2C len: 55 aa. Contains possible hydrophobic membrane spanning regions gene gene5539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5484 SCO5485 SCO5485 SC2A11.19 SC2A11.19 5971544 5971837 + small hydrophobic membrane protein SC2A11.19%2C small hydrophobic membrane protein%2C len: 97 aa. Contains possible hydrophobic membrane spanning regions gene gene5540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5485 SCO5486 SCO5486 SC2A11.20 SC2A11.20 5971928 5973097 + pyridoxal-phosphate-dependent aminotransferase SC2A11.20%2C probable pyridoxal-phosphate-dependent aminotransferase%2C len: 389 aa%3B similar to many e.g. NIFS_ANASP Anaebaena NifS protein (400 aa)%2C fasta scores%3B opt: 855 z-score: 1070.8 E(): 0%2C 40.4%25 identity in 384 aa overlap and SPL1_CANAL Candida albicans tRNA splicing protein SPL1 (488 aa)%2C fasta scores%3B opt: 791 z-score: 912.8 E(): 0%2C 36.6%25 identity in 388 aa overlap. Contains Pfam match to entry PF00266 aminotran_5%2C Aminotransferases class-V%2C score 259.00%2C E-value 6.2e-74 gene gene5541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5486 SCO5487 SCO5487 SC2A11.21c SC2A11.21c 5973134 5973862 - hypothetical protein SC2A11.21c%2C unknown%2C len: 242 aa%3B some similarity in C-terminus to enterobacterial ampD genes e.g. AMPD_ECOLI AMPD protein (183 aa)%2C fasta scores%3B opt: 210 z-score: 212.6 E(): 0.00014%2C 31.5%25 identity in 149 aa overlapand Enterobacter cloacae TR:Q46957 (EMBL:U40785) anhydro-n-acetylmuramyl-tripeptide amidase (187 aa)%2C fasta scores%3B opt: 207 z-score: 192.0 E(): 0.0019%2C 31.6%25 identity in 155 aa overlap gene gene5542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5487 SCO5488 SCO5488 mnmA mnmA 5973924 5975054 + tRNA-specific 2-thiouridylase MnmA catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs gene gene5543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5488 SCO5489 SCO5489 SC8D9.01c SC8D9.01c 5974936 5975874 - hypothetical protein SC8D9.01c%2C unknown%2C len: >299 aa%3B proline and glycine rich. This CDS lies in a region of DNA with high GC content. The CDS lies in frame 4 and was designated based upon a Hidden Markov algorithm prediction. Note that Frameplot predicts two ORFs at (approx.) 125-500bp and 500-902bp. High quality sequence was obtained for this region from two independent cosmids suggesting that a real frameshift exist on the chromosome gene gene5544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5489 SCO5490 SCO5490 SC8D9.02c SC8D9.02c 5975918 5976259 - hypothetical protein SC8D9.02c%2C small conserved hypothetical protein%2C len: 123aa%3B similar to several eg. TR:P96817 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (126 aa) fasta scores%3B opt: 279%2C z-score: 348.2%2C E(): 4.4e-12%2C (42.7%25 identity in 110 aa overlap). gene gene5545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5490 SCO5491 SCO5491 SC8D9.03 SC8D9.03 5976342 5976890 + hypothetical protein SC8D9.03%2C unknown%2C len: 182aa%3B similar to many of undefined function eg. TR:Q49952 (EMBL:U15180) hypothetical protein from Mycobacterium leprae (187 aa) fasta scores%3B opt: 331%2C z-score: 394.0%2C E(): 1.2e-14%2C (36.1%25 identity in 166 aa overlap). gene gene5546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5491 SCO5492 SCO5492 SC8D9.04 SC8D9.04 5976909 5977607 + short chain dehydrogenase SC8D9.04%2C probable oxidoreductase%2C len: 232aa%3B similar to many eg. TR:Q53882 (EMBL:U43704) aklaviketone reductase from Streptomyces sp. strain C5 (251 aa) fasta scores%3B opt: 319%2C z-score: 361.3%2C E(): 8.1e-13%2C (33.3%25 identity in 237 aa overlap). Contains PS00061 Short-chain dehydrogenases/reductases family signature. Also contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase%2C score 129.20%2C E-value 7.5e-35. gene gene5547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5492 SCO5493 SCO5493 SC8D9.05 SC8D9.05 5977775 5978770 + hypothetical protein SC8D9.05%2C unknown%2C len: 331aa%3B similar to others of undefined function eg. TR:O53262 (EMBL:AL021287) hypothetical protein from Mycobacterium tuberculosis (337 aa) opt: 774%2C z-score: 895.1%2C E(): 0%2C (43.4%25 identity in 334 aa overlap). gene gene5548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5493 SCO5494 SCO5494 ligA ligA 5978785 5980992 + NAD-dependent DNA ligase LigA this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction%3B essential for DNA replication and repair of damaged DNA%3B similar to ligase LigB gene gene5549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5494 SCO5495 SCO5495 SC8D9.07 SC8D9.07 5981250 5983490 + phosphodiesterase SC8D9.07%2C possible membrane associated phosphodiesterase%2C len: 746 aa%3B similar to many eg. TR:O87376 (EMBL:AF052518) c-di-GMP phosphodiesterase A from Acetobacter xylinus cdg2 operon (752 aa) fasta scores%3B opt: 959%2C z-score: 1059.2%2C E(): 0%2C (31.7%25 identity in 603 aa overlap). Appears to have two distinct regions with the first 300aa containing several potential membrane spanning hydrophobic regions and the remainder of the protein showing similarity to the phosphodiesterase mentioned above. Also similar to a nearby gene on the same cosmid (SC8D9.22) fasta scores%3B opt: 736%2C z-score: 625.6%2C E(): 5.3e-30%2C (32.6%25 identity in 729 aa overlap). Contains TTA Leu codon%2C possible target for bldA regulation. Also contains Pfam match to entry PF00990 DUF9%2C Domain of unknown function%2C score 166.70%2C E-value 3.9e-46 and Pfam match to entry PF00563 DUF2%2C Domain of unknown function 2%2C score 291.30%2C E-value 1.2e-83. Contains possible hydrophobic membrane spanning regions gene gene5550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5495 SCO5496 SCO5496 SC8D9.08 SC8D9.08 5983774 5984145 + small membrane hydrophobic protein SC8D9.08%2C small hydrophobic membrane protein%2C len: 123 aa%3B no significant database similarities. Contains possible hydrophobic membrane spanning regions gene gene5551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5496 SCO5497 SCO5497 SC8D9.09 SC8D9.09 5984177 5984671 + hypothetical protein SC8D9.09%2C unknown%2C len: 164aa%3B similar to many of undefined function eg. TR:O06336 (EMBL:Z95390) hypothetical protein from Mycobacterium tuberculosis (177 aa) fasta scores%3B opt: 171%2C z-score: 213.4%2C E(): 0.00014%2C (34.9%25 identity in 109 aa overlap). gene gene5552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5497 SCO5498 SCO5498 gatC gatC 5984816 5985112 + aspartyl/glutamyl-tRNA amidotransferase subunit C allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases%3B reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA%3B some Mycoplasma proteins contain an N-terminal fusion to an unknown domain gene gene5553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5498 SCO5499 SCO5499 gatA gatA 5985116 5986609 + aspartyl/glutamyl-tRNA amidotransferase subunit A allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases%3B reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA gene gene5554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5499 SCO5500 SCO5500 SC8D9.12 SC8D9.12 5986606 5986845 + hypothetical protein SC8D9.12%2C membrane protein%2C len: 79 aa. Contains possible hydrophobic membrane spanning regions gene gene5555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5500 SCO5501 SCO5501 gatB gatB 5986861 5988375 + aspartyl/glutamyl-tRNA amidotransferase subunit B allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases%3B reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA gene gene5556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5501 SCO5502 SCO5502 SC8D9.14 SC8D9.14 5988617 5990863 + integral membrane export protein SC8D9.14%2C possible integral membrane export protein%2C len: 748aa%3B similar to many eg. TR:Q53902 (EMBL:M64683) an intergral membrane protein involved in the export of actinorhodin from Streptomyces coelicolor (711 aa) fasta scores%3B opt: 353%2C z-score: 385.2%2C E(): 3.8e-14%2C (28.2%25 identity in 731 aa overlap). gene gene5557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5502 SCO5503 SCO5503 SC8D9.15 SC8D9.15 5990841 5991425 + acetyltransferase SC8D9.15%2C possible acetyltransferase%2C len: 194aa%3B similar to many eg. TR:P96579 (EMBL:AB001488) probable acetyltransferase from Bacillus subtilis (183 aa) fasta scores%3B opt: 250%2C z-score: 327.1%2C E(): 6.5e-11%2C (27.9%25 identity in 172 aa overlap) gene gene5558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5503 SCO5504 SCO5504 SC8D9.16 SC8D9.16 5991461 5992087 + hypothetical protein SC8D9.16%2C possible integral membrane protein%2C len: 208aa%3B alanine-rich%2C contains possible membrane spanning regions. gene gene5559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5504 SCO5505 SCO5505 SC8D9.17 SC8D9.17 5992283 5992468 + hypothetical protein SC8D9.17%2C unknown%2C len: 61 aa gene gene5560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5505 SCO5506 SCO5506 SC8D9.18 SC8D9.18 5992465 5995740 + regulatory protein SC8D9.18%2C possible regulatory protein%2C len: 1091 aa%3B limited similarity to many proteins associated with regulatory functions e.g. C-terminal similarity with C-terminal of TR:O86603 (EMBL:AL031155) transcriptional regulator from Streptomyces coelicolor (892 aa) fasta scores%3B opt: 245%2C z-score: 254.6%2C E(): 7.1e-07%2C (30.6%25 identity in 451 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and a probable helix-turn-helix at 1036-1057aa (+3.98 SD). Also contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 82.70%2C E-value 7.8e-21. gene gene5561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5506 SCO5507 SCO5507 SC8D9.19 SC8D9.19 5995778 5995987 + hypothetical protein SC8D9.19%2C unknown%2C len: 69 aa gene gene5562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5507 SCO5508 SCO5508 SC8D9.20c SC8D9.20c 5995996 5997339 - oxidoreductase SC8D9.20c%2C possible oxidoreductase%2C len: 447aa%3B similar to many of undefined function and SW:DHGB_ACICA glucose dehydrogenase-B from Acinetobacter calcoaceticus (478 aa) fasta scores%3B opt: 247%2C z-score: 253.8%2C E(): 7.9e-07%2C (27.4%25 identity in 369 aa overlap). gene gene5563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5508 SCO5509 SCO5509 SC8D9.21c SC8D9.21c 5997336 5998268 - oxidoreductase SC8D9.21c%2C probable oxidoreductase%2C len: 447aa%3B similar to many both prokaryotic and eukaryotic egs. SW:A115_TOBAC auxin induced protein (probable oxidoreductase) from Nicotiana tabacum (common tobacco) (307 aa) fasta scores%3B opt: 391%2C z-score: 456.6%2C E(): 4e-18%2C (36.7%25 identity in 289 aa overlap) and TR:O07152 (EMBL:Z96801) oxidoreductase from Mycobacterium leprae (306 aa) fasta scores%3B opt: 336%2C z-score: 393.5%2C E(): 1.3e-14%2C (30.8%25 identity in 295 aa overlap). Contains Pfam match to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family%2C score 33.70%2C E-value 4.6e-09. gene gene5564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5509 SCO5510 SCO5510 SC8D9.22 SC8D9.22 5998409 5999350 + dehydrogenase SC8D9.22%2C probable dehydrogenase%2C len: 313aa%3B similar to many both eukaryotic and prokaryotic egs. SW:FDH_SOLTU NAD-dependent formate dehydrogenase from the mitochondria of Solanum tuberosum (potato) (379 aa) fasta scores%3B opt: 372%2C z-score: 413.2%2C E(): 1e-15%2C (29.9%25 identity in 278 aa overlap) and SW:SERA_BACSU D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (525 aa) fasta scores%3B opt: 348%2C z-score: 384.9%2C E(): 3.9e-14%2C (32.4%25 identity in 256 aa overlap). Contains PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3 and Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases%2C score 147.40%2C E-value 5.1e-60. gene gene5565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5510 SCO5511 SCO5511 SC8D9.23 SC8D9.23 5999549 6002875 + membrane associated phophodiesterase SC8D9.23%2C possible large membrane associated phophodiesterase %2C len: 1108aa%3B the first 400aa of this protein appear to contain several potential membrane spanning regions. The remainder shows similarity to several eg. TR:O87378 (EMBL:AF052519) C-DI-GMP phophodiesterase A from Acetobacter xylinum (740 aa) fasta scores%3B opt: 683%2C z-score: 565.4%2C E(): 3.4e-24%2C (27.3%25 identity in 645 aa overlap). Also similar to a nearby gene on the same cosmid (SC8D9.07) fasta scores%3B opt: 736%2C z-score: 499.5%2C E(): 5.6e-23%2C (32.4%25 identity in 728 aa overlap). Contains Pfam match to entries PF00989 PAS%2C PAS domain%2C score 34.90%2C E-value 1.8e-06%2C PF00990 DUF9%2C Domain of unknown function%2C score 167.40%2C E-value 2.3e-46 and PF00563 DUF2%2C Domain of unknown function 2%2C score 152.30%2C E-value 8.3e-42. gene gene5566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5511 SCO5512 SCO5512 ilvB ilvB 6003117 6004958 + acetolactate synthase 1 catalytic subunit acetolactate synthase large subunit%3B catalyzes the formation of 2-acetolactate from pyruvate gene gene5567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5512 SCO5513 SCO5513 ilvH ilvH 6004980 6005504 + acetolactate synthase small subunit with IlvI catalyzes the formation of 2-acetolactate from pyruvate%2C the small subunit is required for full activity and valine sensitivity%3B E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates%2C valine sensitivity and affinity for cofactors%3B also known as acetolactate synthase 3 small subunit gene gene5568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5513 SCO5514 SCO5514 ilvC ilvC 6005643 6006641 + ketol-acid reductoisomerase catalyzes the formation of (R)-2%2C3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis gene gene5569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5514 SCO5515 SCO5515 SC8D9.27 SC8D9.27 6006860 6008449 + D-3-phosphoglycerate dehydrogenase catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis%3B can also reduce alpha ketoglutarate to form 2-hydroxyglutarate gene gene5570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5515 SCO5516 SCO5516 SC8D9.28c SC8D9.28c 6008515 6010080 - integral membrane efflux protein SC8D9.28c%2C probable integral membrane efflux protein%2C len: 521aa%3B Similar to many efflux proteins (confirmed and proposed) most of which appear to be dedicated to drug resistance/export egs. TR:O33968 (EMBL:U80063) transmembrane%2C proton-dependent transport protein from Streptomyces cinnamomeus (519 aa) fasta scores%3B opt: 1342%2C z-score: 1386.9%2C E(): 0%2C (46.5%25 identity in 503 aa overlap) and TR:O52557 (EMBL:AF040570) rifamycin efflux protein from Amycolatopsis mediterranei (522 aa) fasta scores%3B opt: 988%2C z-score: 1022.7%2C E(): 0%2C (38.0%25 identity in 523 aa overlap). Contains multiple potential membrane spanning regions. gene gene5571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5516 SCO5517 SCO5517 SC8D9.29 SC8D9.29 6010146 6010736 + transcriptional regulator SC8D9.29%2C possible transcriptional regulator%2C len: 196 aa%3B some similarity to many e.g. TR:O34381 (EMBL:Z99112) PksA%2C transcriptional regulator%2C involved in regulation of the polyketide synthase operon in Bacillus subtilis (205 aa) fasta scores%3B opt: 108%2C z-score: 141.0%2C E(): 1.5%2C (32.1%25 identity in 56 aa overlap) and TR:O86510 (EMBL:AL031124) transcriptional regulator from Streptomyces coelicolor (200 aa) fasta scores%3B opt: 135%2C z-score: 173.7%2C E(): 0.023%2C (30.9%25 identity in 139 aa overlap). gene gene5572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5517 SCO5518 SCO5518 SC8D9.30c SC8D9.30c 6010717 6011964 - transcriptional regulator SC8D9.30c%2C possible transcriptional regulator%2C len: 521 aa%3B some similarity to TR:Q00509 (EMBL:X63451) SrmR%2C regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens (604 aa) fasta scores%3B opt: 142%2C z-score: 152.0%2C E(): 0.37%2C (28.1%25 identity in 228 aa overlap). Also similar to TR:E1359977 (EMBL:AL034492) transcriptional regulator from Streptomyces coelicolor (569 aa) fasta scores%3B opt: 204%2C z-score: 216.7%2C E(): 9.1e-05%2C (28.6%25 identity in 448 aa overlap). Contains possible helix-turn-helix at 367-388 aa (+2.83 SD). gene gene5573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5518 SCO5519 SCO5519 SC8D9.31 SC8D9.31 6012130 6013056 + hypothetical protein SC8D9.31%2C unknown%2C len: 308aa%3B similar to proteins of undefined function eg. TR:O50444 (EMBL:AL010186) from Mycobacterium tuberculosis (329 aa) fasta scores%3B opt: 984%2C z-score: 1121.1%2C E(): 0%2C (50.0%25 identity in 312 aa overlap). gene gene5574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5519 SCO5520 SCO5520 SC1C2.01 SC1C2.01 6013103 6014743 + 1-pyrroline-5-carboxylate dehydrogenase SC1C2.01%2C probable delta-1-pyrroline-5-carboxylate dehydrogenase%2C partial CDS%2C len >408 aa%3B similar to many e.g. TR:O50443 (EMBL:AL010186) delta-1-pyrroline-5-carboxylate dehydrogenase (M. tuberculosis) (543 aa)%2C fasta scores%3B opt: 1753 z-score: 2214.2 E(): 0%2C 65.1%25 identity in 407 aa overlap%2C and PUT2_HUMAN delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa)%2C fasta scores%3B opt: 1273 z-score: 1730.4 E(): 0%2C 48.5%25 identity in 408 aa overlap. Contains PS00687 and PS00070 Aldehyde dehydrogenases glutamic acid active site and cysteine active site and Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenases%2C score 114.70%2C E-value 1.8e-30~SC8D9.32%2C partial CDS%2C probable pyrroline-5-carboxylate dehydrogenase%2C len: >182aa%3B similar to many eg. TR:O50443 (EMBL:AL010186) RocA%2C probable pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis (543 aa) fasta scores%3B opt: 843%2C z-score: 1024.6%2C E(): 0%2C (66.5%25 identity in 182 aa overlap) and SW:PUT2_AGABI PruA%2C delta 1-pyrroline-5-carboxylate dehydrogenase from Agaricus bisporus (common mushroom) (546 aa) fasta scores%3B opt: 521%2C z-score: 634.9%2C E(): 4.7e-28%2C (44.5%25 identity in 182 aa overlap). gene gene5575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5520 SCO5521 SCO5521 SC1C2.02 SC1C2.02 6015052 6015183 + hypothetical protein SC1C2.02%2C questionable ORF%2C len: 43 aa gene gene5576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5521 SCO5522 SCO5522 leuB leuB 6015259 6016302 + 3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis gene gene5577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5522 SCO5523 SCO5523 ilvE ilvE 6016567 6017655 + branched-chain amino acid aminotransferase catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids gene gene5578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5523 SCO5524 SCO5524 SC1C2.05c SC1C2.05c 6017729 6019159 - transmembrane transport protein SC1C2.05c%2C possible transmembrane transport protein%2C len: 476 aa%3B similar to e.g. B. subtilis TR:P94369 (EMBL:D83026) yxlA (homologous to purine-cytosine permease) (457 aa)%2C fasta scores%3B opt: 235 z-score: 377.4 E(): 9e-14%2C 24.0%25 identity in 475 aa overlap gene gene5579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5524 SCO5525 SCO5525 ureAB ureAB 6019304 6019987 + bifunctional urease subunit gamma/beta ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide%3B in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa%3B the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits gene gene5580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5525 SCO5526 SCO5526 ureC ureC 6019984 6021660 + urease subunit alpha ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide%3B in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa%3B the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits gene gene5581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5526 SCO5527 SCO5527 SC1C2.08 SC1C2.08 6021711 6022730 + hypothetical protein SC1C2.08%2C unknown%2C len: 339 aa%3B similar to two hypothetical proteins TR:O41120 (EMBL:U42580) A638R protein from Paramecium bursaria chlorella virus 1 (360 aa)%2C fasta scores%3B opt: 635 z-score: 688.3 E(): 4.4e-31%2C 35.0%25 identity in 343 aa overlapTR:O24890 (EMBL:AE000526) HP0049 from Helicobacter pylori (330 aa)opt: 416 z-score: 316.9 E(): 2.1e-10%2C 25.5%25 identity in 337 aa overlap gene gene5582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5527 SCO5528 SCO5528 SC1C2.09 SC1C2.09 6022748 6023350 + transcriptional regulator SC1C2.09%2C possible transcriptional regulator%2C len: 200 aa%3B some similarity to e.g. TR:O34381 (EMBL:Z99112) transcriptional regulator PksA from Bacillus subtilis (205 aa)%2C fasta scores%3B opt: 182 z-score: 206.5 E(): 0.0003%2C 26.5%25 identity in 185 aa overlap. Contains probable helix-turn-helix motif at aa 32-53 (Score 1136%2C +3.06 SD) and Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family%2C score 35.50%2C E-value 4.1e-08 gene gene5583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5528 SCO5529 SCO5529 SC1C2.10 SC1C2.10 6023669 6025273 + (R)-citramalate synthase catalyzes the formation of 2-isopropylmalate from 1-methyl-2-oxobutanoate and acetyl-CoA gene gene5584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5529 SCO5530 SCO5530 SC1C2.11 SC1C2.11 6025338 6026690 + hypothetical protein SC1C2.11%2C membrane protein%2C len: 450 aa%3B contains probable hydrophobic membrane spanning regions and highly Gly-rich C-terminus gene gene5585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5530 SCO5531 SCO5531 SC1C2.12c SC1C2.12c 6026708 6027712 - hypothetical protein SC1C2.12c%2C probable integral membrane protein%2C len: 334 aa%3B similar to TR:Q98DR8 (EMBL:AP003004) Rhizobium loti (Mesorhizobium loti) integral membrane protein MLL4580%2C 308 aa%3B fasta scores: opt: 503 Z-score: 515.3 E(): 4.5e-21%3B 33.904%25 identity in 292 aa overlap. COntains possible hydrophobic membrane spanning regions gene gene5586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5531 SCO5532 SCO5532 SC1C2.13 SC1C2.13 6027804 6028388 + transcriptional regulator SC1C2.13%2C probable transcriptional regulator%2C len: 194 aa%3B simialr to many e.g. S. lividans TR:G3293540 (EMBL:AF072709) transcriptional regulator (192 aa)%2C fasta scores%3B opt: 342 z-score: 493.9 E(): 2.9e-20%2C 42.0%25 identity in 181 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family%2C score 30.80%2C E-value 8.3e-07 gene gene5587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5532 SCO5533 SCO5533 SC1C2.14c SC1C2.14c 6028474 6029031 - hypothetical protein SC1C2.14c%2C unknown%2C len: 185 aa%3B similar to hypothetical proteins from E. coli YCEI_ECOLI (191 aa)%2C fasta scores%3B opt: 373 z-score: 567.7 E(): 2.3e-24%2C 34.1%25 identity in 179 aa overlap and H. pylori TR:O25873 (EMBL:AE000633) HP1286 (182 aa)%2C fasta scores%3B opt: 279 z-score: 242.2 E(): 3.1e-06%2C 27.9%25 identity in 172 aa overlap gene gene5588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5533 SCO5534 SCO5534 SC1C2.15 SC1C2.15 6029180 6031510 + lyase SC1C2.15%2C possible lyase%2C len: 776 aa%3B similar to hyaluronidase from several organisms e.g. Propionibacterium acnes TR:Q59634 (EMBL:U15927) hyaluronidase (EC 4.2.2.1) (hyaluronate lyase) (752 aa)%2C fasta scores%3B opt: 407 z-score: 783.6 E(): 0%2C 31.5%25 identity in 781 aa overlap. Contains N-tertminal signal sequence gene gene5589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5534 SCO5535 SCO5535 SC1C2.16 SC1C2.16 6031665 6033248 + carboxyl transferase SC1C2.16%2C probable carboxyl transferase%2C len: 527 aa%3B similar to many e.g. Veillonella parvula TR:Q57079 (EMBL:Z24754) alpha-subunit%2C methylmalonyl-coa decarboxylase (509 aa)%2C fasta scores%3B opt: 1929 z-score: 2387.4 E(): 0%2C 55.9%25 identity in 510 aa overlap and Myxococcus xanthus TR:O24789 (EMBL:AB007000) propionyl-coa carboxylase (524 aa)%2C fasta scores%3B opt: 1922 z-score: 2359.6 E(): 0%2C 55.7%25 identity in 528 aa overlap gene gene5590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5535 SCO5536 SCO5536 SC1C2.17 SC1C2.17 6033266 6033463 + hypothetical protein SC1C2.17%2C unknown%2C len: 65 aa gene gene5591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5536 SCO5537 SCO5537 cvnD2 cvnD2 6033766 6034290 - ATP/GTP binding protein SC1C2.18c%2C cvnD2%2C probable ATP/GTP binding protein%2C len: 174 aa%3B similar to prokaryotic hypothetical proteins e.g. M. tuberculosis TR:O50391 (EMBL:AL009198) MTV004.19C (193 aa)%2C fasta scores%3B opt: 756 z-score: 1186.3 E(): 0%2C 67.4%25 identity in 175 aa overlap%2C and more distantly to the yeast GTP-binding protein SEC4_YEAST RAS-related protein SEC4 (215 aa)%2C fasta scores%3B opt: 113 z-score: 244.1 E(): 2.4e-06%2C 24.6%25 identity in 191 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop). 97.1%25 identical to upstream gene SC1C2.22c gene gene5592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5537 SCO5538 SCO5538 cvnC2 cvnC2 6034328 6034900 - hypothetical protein SC1C2.19c%2C cvnC2%2C unknown%2C len: 190 aa%3B N-terminus is Pro-rich%2C C-terminus has similarity to M. tuberculosis hypothetical protein TR:O50392 (EMBL:AL009198) MTV004.20C (122 aa)%2C fasta scores%3B opt: 231 z-score: 217.7 E(): 7.1e-05%2C 41.0%25 identity in 122 aa overlap. C-terminus is 84.7%25 identical to upstream gene SC3A9.23c gene gene5593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5538 SCO5539 SCO5539 cvnB2 cvnB2 6034995 6035417 - hypothetical protein SC1C2.20c%2C cvnB2%2C unknown%2C len: 140 aa%3B similar to M. tuberculosis hypothetical protein TR:O50393 (EMBL:AL009198) MTV004.21c (130 aa)%2C fasta scores%3B opt: 445 z-score: 754.7 E(): 0%2C 56.9%25 identity in 116 aa overlap. 94.2%25 identical to upstream gene SC1C2.24c gene gene5594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5539 SCO5540 SCO5540 cvnA2 cvnA2 6035419 6038754 - hypothetical protein SC1C2.21c%2C cvnA2%2C unknown%2C len: 1111 aa%3B contains two possible transmembrane domains at around 100 and 400 aa%2C a Gln-rich region at around 850 aa and a probable coiled-coil domain from 297 to 327. Overall 35.6%25 identical to upstream gene SC1C2.25c%2C but with much higher similarity between aa 477 and 719 gene gene5595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5540 SCO5541 SCO5541 cvnD1 cvnD1 6039089 6039613 - ATP-GTP binding protein SC1C2.22c%2C cvnD1%2C probable ATP /GTP binding protein%2C len: 174 aa%3B similar to prokaryotic hypothetical proteins e.g. M. tuberculosis TR:O50391 (EMBL:AL009198) MTV004.19C (193 aa)%2C fasta scores%3B opt: 718 z-score: 1252.2 E(): 0%2C 64.9%25 identity in 168 aa overlap%2C and more distantly to the yeast GTP-binding protein SEC4_YEAST RAS-related protein SEC4 (215 aa)%2C fasta scores%3B opt: 111 z-score: 192.5 E(): 0.0018%2C 25.0%25 identity in 128 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop). 97.1%25 identitical to downstream gene SC1C2.18c gene gene5596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5541 SCO5542 SCO5542 cvnC1 cvnC1 6039645 6040043 - hypothetical protein SC1C2.23c%2C cvnC1%2C unknown%2C len: 132 aa%3B similar to M. tuberculosis hypothetical protein TR:O50392 (EMBL:AL009198) MTV004.20C (122 aa)%2C fasta scores%3B opt: 236 z-score: 328.3 E(): 4.9e-11%2C 38.5%25 identity in 122 aa overlap. C-terminus is 84.7%25 identical to downstream gene SC1C2.19c gene gene5597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5542 SCO5543 SCO5543 cvnB1 cvnB1 6040155 6040568 - hypothetical protein SC1C2.24c%2C cvnB1%2C unknown%2C len: 137 aa%3B M. tuberculosis hypothetical protein TR:O50393 (EMBL:AL009198) MTV004.21c (130 aa)%2C fasta scores%3B opt: 466 z-score: 804.8 E(): 0%2C 58.6%25 identity in 116 aa overlap. 94.2%25 identical to downstream gene SC1C2.20c gene gene5598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5543 SCO5544 SCO5544 cvnA1 cvnA1 6040578 6044567 - hypothetical protein SC1C2.25c%2C cvnA1%2C unknown%2C len: 1329 aa%3B contains two possible transmembrane domains at around 100 and 400 aa%2C and probable coiled-coil domains from 112 to 144 and 360 to 398. Overall 35.6%25 identical to downstream gene SC1C2.22c%2C but with much higher similarity between aa 468 and 709 gene gene5599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5544 SCO5545 SCO5545 SC1C2.26 SC1C2.26 6045182 6045358 + hypothetical protein SC1C2.26%2C unknown%2C len: 58 aa gene gene5600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5545 SCO5546 SCO5546 SC1C2.27 SC1C2.27 6045485 6046270 + hypothetical protein SC1C2.27%2C unknown%2C len: 261 aa%3B similar to hypothetical proteins e.g. E. coli TR:P76004 (EMBL:AE000216) O219 (219 aa)%2C fasta scores%3B opt: 555 z-score: 764.8 E(): 0%2C 45.7%25 identity in 208 aa overlap and to e.g. HPCE_ECOLI 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase (405 aa)%2C fasta scores%3B opt: 389 z-score: 507.2 E(): 5.3e-21%2C 33.9%25 identity in 218 aa overlap gene gene5601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5546 SCO5547 SCO5547 gltX gltX 6046263 6047747 + glutamyl-tRNA synthetase Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation gene gene5602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5547 SCO5548 SCO5548 SC1C2.29 SC1C2.29 6047855 6048250 + hypothetical protein SC1C2.29%2C unknown%2C len: 131 aa%3B similar to M. tuberculosis hypothetical protein TR:O07205 (EMBL:Z96072) MTCY05A6.25 (142 aa)%2C fasta scores%3B opt: 149 z-score: 314.1 E(): 3e-10%2C 34.7%25 identity in 121 aa overlap gene gene5603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5548 SCO5549 SCO5549 SC1C2.30 SC1C2.30 6048321 6049055 + hydrolase SC1C2.30%2C probable hydrolase%2C len: 244 aa%3B similar to hypothetical proteins from many organisms and to HAD1_PSESP 2-haloalkanoic acid dehalogenase I (EC 3.8. (227 aa)%2C fasta scores%3B opt: 201 z-score: 261.1 E(): 2.7e-07%2C 30.4%25 identity in 237 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase%2C score 43.50%2C E-value 4.8e-09 gene gene5604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5549 SCO5550 SCO5550 SC1C2.31c SC1C2.31c 6049735 6050379 - transcriptional regulator SC1C2.31c%2C probable transcriptional regulator%2C len: 214 aa%3B N-terminus is similar to the N-terminus of members of the MerR family%2C e.g. MERR_THIFE mercuric resistance operon regulatory protein (122 aa)%2C fasta scores%3B opt: 111 z-score: 189.7 E(): 0.0026%2C 30.3%25 identity in 66 aa overlap. Contains probable helix-turn-helix motif at aa 2-23 (1799%2C +5.31 SD) gene gene5610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5550 SCO5551 SCO5551 SC1C2.32 SC1C2.32 6050461 6051033 + hypothetical protein SC1C2.32%2C unknown%2C len: 190 aa gene gene5611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5551 SCO5552 SCO5552 SC1C2.33c SC1C2.33c 6051099 6051815 - regulator SC1C2.33c%2C probable regulator%2C len: 238 aa%3B similar to many e.g. GYLR_STRGR glycerol operon regulatory protein (254 aa)%2C fasta scores%3B opt: 146 z-score: 237.0 E(): 5.9e-06%2C 28.9%25 identity in 246 aa overlap gene gene5612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5552 SCO5553 SCO5553 leuC leuC 6052013 6053443 + 3-isopropylmalate dehydratase large subunit dehydratase component%2C catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate gene gene5613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5553 SCO5554 SCO5554 leuD leuD 6053449 6054042 + 3-isopropylmalate dehydratase small subunit catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis%3B forms a heterodimer of LeuC/D gene gene5614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5554 SCO5555 SCO5555 SC1C2.36 SC1C2.36 6054328 6054558 + hypothetical protein SC1C2.36%2C unknown%2C len: 76 aa gene gene5615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5555 SCO5556 SCO5556 SC1C2.37 SC1C2.37 6054696 6055352 + histone-like DNA binding protein SC1C2.37%2C histone-like DNA binding protein%2C len: 218 aa%3B N-terminus is highly simialar to many bacterial HU proteins e.g. DBHB_ECOLI DNA-binding protein HU-beta (NS1) (HU-1) (90 aa)%2C fasta scores%3B opt: 230 z-score: 300.3 E(): 1.8e-09%2C 40.0%25 identity in 90 aa overlap%2C and contains PS00045 Bacterial histone-like DNA-binding proteins signature and Pfam match to entry PF00216 Bac_DNA_binding%2C Bacterial DNA-binding proteins%2C score 104.40%2C E-value 9.2e-29. C-terminus contains 18 degenerate repeats of an (A /T)(3-5)KK motif. A similar C-terminal extension is also present in the M. tuberculosis homologue TR:P95109 (EMBL:Z83018) dna-binding protein MTCY349.01 (214 aa)%2C fasta scores%3B opt: 563 z-score: 543.5 E(): 5e-23%2C 50.9%25 identity in 220 aa overlap%2C and to a lesser extent in the M. leprae homologue. The repeats are simlar to those in hrdB (SC5B8.10%2C 45.4%25 identity in 97 aa overlap) gene gene5616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5556 SCO5557 SCO5557 SC1C2.38c SC1C2.38c 6055467 6055700 - hypothetical protein SC1C2.38c%2C unknown%2C len: 77 aa gene gene5617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5557 SCO5557a SCO5557a SC7A1.01c SC7A1.01c 6055710 6056348 - hypothetical protein SC7A1.01c%2C unknown%2C len: 212 aa%3B similar to TR:P95112 (EMBL:Z83018) hypothetical protein from Mycobacterium tuberculosis (214 aa) fasta scores%3B opt: 420%2C z-score: 422.3%2C E(): 3.1e-16%2C (43.5%25 identity in 207 aa overlap) and TR:O33128 (EMBL:Z99263) hypothetical protein from Mycobacterium leprae (216 aa) fasta scores%3B opt: 386%2C z-score: 414.0%2C E(): 9.1e-16%2C (40.6%25 identity in 207 aa overlap). gene gene5618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5557a SCO5558 SCO5558 SC7A1.02 SC7A1.02 6056492 6057286 + acyltransferase SC7A1.02%2C possible acyltransferase%2C len: 264aa%3B similar to several proposed acyltransferases eg. TR:O07809 (EMBL:Z97188) acyltransferase from Mycobacterium tuberculosis (251 aa) fasta scores%3B opt: 266%2C z-score: 384.5%2C E(): 4e-14%2C (29.7%25 identity in 229 aa overlap). gene gene5619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5558 SCO5559 SCO5559 gpsA gpsA 6057283 6058293 + NAD(P)H-dependent glycerol-3-phosphate dehydrogenase catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate gene gene5620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5559 SCO5560 SCO5560 ddl ddl 6058385 6059554 + D-alanyl-alanine synthetase A D-alanine--D-alanine ligase%3B DdlA%3B DdlB%3B cytoplasmic%3B catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis%3B there are two forms of this enzyme in Escherichia coli gene gene5621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5560 SCO5561 SCO5561 SC7A1.05c SC7A1.05c 6059732 6059965 - hypothetical protein SC7A1.05c%2C conserved hypothetical protein%2C len: 77 aa%3B similar to several /hypotheticals eg. TR:O28868 (EMBL:AE001007) proposed transcriptional regulatory protein from Archaeoglobus fulgidus (77 aa) fasta scores%3B opt: 123%2C z-score: 217.3%2C E(): 8.3e-05%2C (31.9%25 identity in 69 aa overlap). gene gene5622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5561 SCO5562 SCO5562 SC7A1.06 SC7A1.06 6060199 6061167 + thiamine monophosphate kinase catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP gene gene5623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5562 SCO5563 SCO5563 SC7A1.07 SC7A1.07 6061164 6061973 + phosphomethylpyrimidine kinase SC7A1.07%2C thiD%2C phosphomethylpyrimidine kinase %2C len: 269aa%3B similar to many eg. SW:THID_SALTY ThiD%2C phosphomethylpyrimidine kinase from Salmonella typhimurium (266 aa) fasta scores%3B opt: 588%2C z-score: 737.2%2C E(): 0%2C (42.1%25 identity in 259 aa overlap). Note: thiAB (arbitrarily named) previously mapped to this region of the chromosome. gene gene5624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5563 SCO5564 SCO5564 rpmB rpmB 6062059 6062244 - 50S ribosomal protein L28 required for 70S ribosome assembly gene gene5625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5564 SCO5565 SCO5565 SC7A1.09 SC7A1.09 6062511 6064280 + hypothetical protein SC7A1.09%2C unknown%2C len: 589 aa%3B similar to several hypothetical proteins eg.TR:O34751 (EMBL:Z99112) YLOV protein from Bacillus subtilis (553 aa) fasta scores%3B opt: 656%2C z-score: 464.3%2C E(): 1.4e-18%2C (28.9%25 identity in 582 aa overlap) and to TR:AAK47378 (EMBL:AE007126) Mycobacterium tuberculosis CDC1551 hypothetical protein MT3052%2C 470 aa%3B fasta scores: opt: 772 Z-score: 726.0 E(): 8.3e-33%3B 40.974%25 identity in 493 aa overlap gene gene5626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5565 SCO5566 SCO5566 SC7A1.10 SC7A1.10 6064343 6066571 + ATP-dependent DNA helicase RecG catalyzes branch migration in Holliday junction intermediates gene gene5627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5566 SCO5567 SCO5567 SC7A1.11 SC7A1.11 6066627 6067214 + DNA methylase SC7A1.11%2C possible DNA methylase%2C len: 195aa%3B similar to many hypotheticals some of which contain PS00092 N-6 Adenine-specific DNA methylases signature eg. SW:YHHF_ECOLI hypothetical protein from Escherichia coli (198 aa) fasta scores%3B opt: 340%2C z-score: 430.7%2C E(): 1.1e-16%2C (35.8%25 identity in 193 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature although not in the expected N-terminal region. gene gene5628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5567 SCO5568 SCO5568 coaD coaD 6067241 6067720 + phosphopantetheine adenylyltransferase Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA gene gene5629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5568 SCO5569 SCO5569 SC7A1.13 SC7A1.13 6067854 6068993 + hypothetical protein SC7A1.13%2C unknown%2C len: 379 aa%3B similar to TR:O69467 (EMBL:AL023635) hypothetical protein from Mycobacterium tuberculosis (245 aa) fasta scores%3B opt: 254%2C z-score: 388.8%2C E(): 2.3e-14%2C (29.5%25 identity in 234 aa overlap). Contains probable coiled-coil from 82 to 124 (43 residues) Max score: 1.615 (probability 1.00). gene gene5630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5569 SCO5570 SCO5570 SC7A1.14 SC7A1.14 6069138 6069791 + hypothetical protein SC7A1.14%2C unknown%2C len: 217 aa%3B similar to Y06F_MYCTU hypothetical protein from Mycobacterium tuberculosis (207 aa) fasta scores%3B opt: 244%2C z-score: 699.9%2C E(): 1.1e-31%2C (45.5%25 identity in 189 aa overlap). gene gene5631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5570 SCO5571 SCO5571 rpmF rpmF 6069794 6069967 + 50S ribosomal protein L32 some L32 proteins have zinc finger motifs consisting of CXXC while others do not gene gene5632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5571 SCO5572 SCO5572 rnc rnc 6069987 6070805 + ribonuclease III cytoplasmic enzyme involved in processing rRNA and some mRNAs%3B substrates typically have dsRNA regions%3B forms a homodimer%3B have N-terminal nuclease and C-terminal RNA-binding domains%3B requires magnesium as preferred ion for activity gene gene5633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5572 SCO5573 SCO5573 SC7A1.17 SC7A1.17 6070914 6071774 + formamidopyrimidine-DNA glycosylase Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases gene gene5634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5573 SCO5574 SCO5574 SC7A1.18c SC7A1.18c 6071764 6072189 - hypothetical protein SC7A1.18c%2C conserved hypothetical protein%2C len: 141aa%3B similar to many eg. SW:YTFH_ECOLI from Escherichia coli (156 aa) fasta scores%3B opt: 396%2C z-score: 679.8%2C E(): 1.4e-30%2C (48.9%25 identity in 131 aa overlap) Also similar to SC1F2.10 (EMBL:AL031350) unknown protein from Streptomyces coelicolor (135 aa) fasta scores%3B opt: 305%2C z-score: 398.0%2C E(): 2.2e-17 (42.4%25 identity in 132 aa overlap). gene gene5635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5574 SCO5575 SCO5575 SC7A1.19c SC7A1.19c 6072276 6073466 - transmembrane protein SC7A1.19c%2C possible transmembrane protein%2C len: 396aa%3B some similarity to TR:O31398 (EMBL:AJ222587) hypothetical%2C protein from Bacillus subtilis (257 aa) opt: 341%2C z-score: 212.5%2C E(): 0.00015%2C (39.5%25 identity in 167 aa overlap). GC rich 17100-17400. Contains possible transmembrane region. gene gene5636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5575 SCO5576 SCO5576 SC7A1.20 SC7A1.20 6073650 6073931 + acylphosphatase catalyzes the hydrolysis of acylphosphate gene gene5637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5576 SCO5577 SCO5577 SC7A1.21 SC7A1.21 6074834 6078394 + chromosome associated protein SC7A1.21%2C possible chromosome associated protein%2C len: 1186aa%3B similar to many hypotheticals eg. SW:Y06B_MYCTU hypothetical protein from Mycobacterium tuberculosis (1289 aa) fasta scores%3B opt: 2637%2C z-score: 2806.3%2C E(): 0%2C (53.1%25 identity in 1205 aa overlap) with weak similarity to a family of chromosome associated proteins e.g. SW:SCII_CHICK chromosome scaffold protein SCII from chicken (Gallus gallus) (1189 aa) opt: 370%2C z-score: 383.3%2C E(): 4.7e-14%2C (22.6%25 identity in 1246 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop). Also contains 2 probable coiled coil regions from 162 to 492 and from 654 to 1041. gene gene5638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5577 SCO5578 SCO5578 SC7A1.22 SC7A1.22 6078582 6080000 + sugar transporter SC7A1.22%2C sugar transporter%2C len: aa%3B similar to many eg. SW:GLCP_SYNY3 glucose transport protein from Synechocystis sp. (468 aa) fasta scores%3B opt: 1477%2C z-score: 1527.5%2C E(): 0%2C (50.6%25 identity in 468 aa overlap). Contains PS00217 Sugar transport proteins signature 2%2C PS00216 Sugar transport proteins signature 1 and Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter%2C score 404.10%2C E-value 1.3e-117. Also contains several possible transmembrane regions. gene gene5639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5578 SCO5579 SCO5579 SC7A1.23c SC7A1.23c 6080126 6081583 - transmembrane protein SC7A1.23c%2C possible transmembrane protein%2C len: 485aa%3B similar to many and hypothetical proteins eg. EMBL:E1312898 transmembrane transport protein from Streptomyces coelicolor (476 aa) fasta scores%3B opt: 482%2C z-score: 311.0%2C E(): 5e-10%2C (26.4%25 identity in 473 aa overlap) Also weakly similar to SW:BETT_ECOLI high-affinity choline transport protein from Escherichia coli (677 aa) opt: 74%2C z-score: 196.3%2C E(): 0.0012%2C (23.0%25 identity in 283 aa overlap). Contains several possible transmembrane regions. Also similar to SC1C2.05c (EMBL:AL031124) possible transmembrane transport protein from Streptomyces coelicolor (476 aa) fasta scores%3B opt: 482%2C z-score: 215.0%2C E(): 3.4e-07%2C (26.4%25 identity in 473 aa overlap) gene gene5640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5579 SCO5580 SCO5580 SC7A1.24 SC7A1.24 6081738 6082976 + docking protein SC7A1.24%2C ftsY%2C prokaryotic docking protein%2C len: 412aa%3B similar to many including SW:FTSY_ECOLI functional homolog of the mammalian SRP receptor (docking protein) from Escherichia coli (497 aa) fasta scores%3B opt: 885%2C z-score: 906.8%2C E(): 0%2C (40.7%25 identity in 388 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C PS00300 SRP54-type proteins GTP-binding domain signature and Pfam match to entry PF00448 SRP54%2C SRP54-type protein%2C score 323.90%2C E-value 1.8e-93. Contains possible hydrophobic membrane spanning region gene gene5641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5580 SCO5581 SCO5581 SC7A1.25c SC7A1.25c 6083101 6083772 - hypothetical protein SC7A1.25c%2C hypothetical protein%2C len: 223 aa%3B similar to TR:Q9K3U7 (EMBL:AL359988) Streptomyces coelicolor conserved hypothetical protein SCD10.30c%2C 217 aa%3B fasta scores: opt: 514 Z-score: 547.5 E(): 7.3e-23%3B 44.974%25 identity in 189 aa overlap gene gene5642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5581 SCO5582 SCO5582 SC7A1.26 SC7A1.26 6084219 6085721 + regulator SC7A1.26%2C possible regulator%2C len: 500aa%3B similar to TR:Q53958 (EMBL:M80614) sporulation-associated protein from Streptomyces coelicolor (473 aa) fasta scores%3B opt: 612%2C z-score: 589.9%2C E(): 1.5e-25%2C (31.3%25 identity in 485 aa overlap) and TR:E1319689 (EMBL:AL031541) transcriptional regulator from Streptomyces coelicolor (446 aa) fasta scores%3B opt: 279%2C z-score: 413.7%2C E(): 9.5e-16%2C (25.9%25 identity in 478 aa overlap) gene gene5643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5582 SCO5583 SCO5583 SC7A1.27 SC7A1.27 6086031 6087377 + ammonium transporter SC7A1.27%2C amt%2C ammonium transporter%2C len: 448 aa%3B similar to many eg. TR:O67997 (EMBL:AF005275) (438 aa) fasta scores%3B opt: 1224%2C z-score: 1126.9%2C E(): 0%2C (47.1%25 identity in 414 aa overlap). Contains PS01219 Ammonium transporters signature and Pfam match to entry PF00909 Ammonium_transp%2C Ammonium Transporter Family%2C score 537.00%2C E-value 1.3e-157. gene gene5644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5583 SCO5584 SCO5584 glnB glnB 6087374 6087712 + nitrogen regulatory protein P-II SC2E1.01%2C glnB%2C nitrogen regulatory protein P-II%2C partial CDS%2C len: >54 aa%3B highly similar to many e.g. GLNB_AZOBR (112 aa)%2C fasta scores%3B opt: 198 z-score: 381.9 E(): 4.9e-14%2C 50.0%25 identity in 54 aa overlap~SC7A1.28%2C partial CDS%2C glnB%2C nitrogen regulatory protein P-II%2C len: 92aa%3B similar to many eg. SW:GLNB_RHIME nitrogen regulatory protein P-II from Rhizobium meliloti (112 aa) fasta scores%3B opt: 402%2C z-score: 776.2%2C E(): 0%2C (58.7%25 identity in 92 aa overlap). Contains PS00496 P-II protein urydylation site and Pfam match to entry PF00543 P-II%2C Nitrogen regulatory protein P-II%2C score 116.60%2C E-value 7.1e-34. gene gene5645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5584 SCO5585 SCO5585 glnD glnD 6087777 6090284 + PII uridylyl-transferase catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein%3B also involved in adenylylating and deadelnylyating GlnK gene gene5646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5585 SCO5586 SCO5586 ffh ffh 6090281 6091933 + signal recognition particle protein SC2E1.03%2C ffh%2C signal recognition particle protein%2C len: 550 aa%3B highly similar to mnay e.g. SR54_ECOLI (453 aa)%2C fatsa scores%3B opt: 1465 z-score: 1282.8 E(): 0%2C 50.0%25 identity in 458 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00300 SRP54-type proteins GTP-binding domain signature and Pfam match to entry SRP54 PF00448%2C SRP54-type proteins%2C score 66.57. Similarities suggest possible start site at aa 35 gene gene5647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5586 SCO5587 SCO5587 ftsH ftsH 6092050 6093996 + cell division protein FtsH-like protein SC2E1.04%2C ftsH%2C cell division protein FtsH homolog (zinc metalloprotease%2C integral membrane protein)%2C len: 648 aa%3B similar to many e.g. FTSH_LACLA (695 aa)%2C fasta scores%3B opt: 1489 z-score: 1195.5 E(): 0%2C 41.7%25 identity in 640 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00674 AAA-protein family signature and Pfam matches to entry AAA PF00004%2C ATPases associated with various cellular activities (AAA) and to entry zn-protease PF00099%2C Zinc-binding metalloprotease domain%2C score 22.07%2C score 357.96. Proline-rich N-terminus is not present in other ftsH homologs gene gene5648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5587 SCO5588 SCO5588 SC2E1.05c SC2E1.05c 6094014 6094631 - lipoprotein SC2E1.05c%2C probable lipoprotein%2C len: 205 aa%3B contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5588 SCO5589 SCO5589 SC2E1.06c SC2E1.06c 6094782 6095669 - hypothetical protein SC2E1.06c%2C unknown%2C len: 295 aa gene gene5650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5589 SCO5590 SCO5590 SC2E1.07 SC2E1.07 6096339 6096935 + hypothetical protein SC2E1.07%2C unknown%2C len: 198 aa gene gene5651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5590 SCO5591 SCO5591 rpsP rpsP 6097191 6097610 + 30S ribosomal protein S16 binds to lower part of 30S body where it stabilizes two domains%3B required for efficient assembly of 30S%3B in Escherichia coli this protein has nuclease activity gene gene5652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5591 SCO5592 SCO5592 SC2E1.09 SC2E1.09 6097613 6097852 + hypothetical protein SC2E1.09%2C unknown%2C len: 79 aa%3B highly similar to small hypothetical proteins from several organisms%2C e.g. YX40_MYCTU MTCY274.40c (80 aa)%2C fasta scores%3B opt: 356 z-score:628.4 E(): 9.1e-28%2C 71.6%25 identity in 74 aa overlap gene gene5653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5592 SCO5593 SCO5593 rimM rimM 6097964 6098530 + 16S rRNA-processing protein RimM Essential for efficient processing of 16S rRNA gene gene5654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5593 SCO5594 SCO5594 trmD trmD 6098530 6099363 + tRNA (guanine-N(1)-)-methyltransferase methylates guanosine-37 in various tRNAs%3B uses S-adenosyl-L-methionine to transfer methyl group to tRNA gene gene5655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5594 SCO5595 SCO5595 rplS rplS 6099500 6099850 + 50S ribosomal protein L19 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site gene gene5656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5595 SCO5596 SCO5596 sip1 sip1 6099896 6100675 + signal peptidase I SC2E1.13%2C sip1%2C probable signal peptidase I%2C len: 259 aa%3B similar to many e.g. LEP_HAEIN signal peptidase I (EC 3.4.21.89) (349 aa)%2C fasta scores%3B opt: 162 z-score: 381.2 E(): 5.3e-14%2C 32.5%25 identity in 243 aa overlap%2C though with large internal deletions. Contains PS00761 Signal peptidases I signature 3%2C Pfam match to entry signal_pept_I PF00461%2C Signal peptidases I%2C score 51.12 and probable transmembrane domain. Also similar to downstream genes sip2 (E(): 9.7e-26%2C 44.9%25 identity in 274 aa overlap)%2C sip3 (E(): 4.8e-16%2C 35.6%25 identity in 264 aa overlap) and sip4 (E(): 8.7e-08%2C 37.0%25 identity in 219 aa overlap). Contains possible hydrophobic membrane spanning region gene gene5657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5596 SCO5597 SCO5597 sip2 sip2 6100668 6102008 + signal peptidase I SC2E1.14%2C sip2%2C probable signal peptidase I%2C len: 446 aa%3B similar to many e.g. LEP_HAEIN signal peptidase I (EC 3.4.21.89) (349 aa)%2C fasta scores%3B opt: 151%2C z-score: 317.3 E(): 1.9e-10%2C 30.1%25 identity in 286 aa overlap. Contains PS00761 Signal peptidases I signature 3%2C Pfam match to entry signal_pept_I PF00461%2C Signal peptidases I%2C score 42.41 and probable transmembrane domain. Also similar to surrounding genes sip1 (E(): 9.7e-24%2C 44.9%25 identity in 274 aa overlap)%2C sip3 (E(): 1.8e-28%2C 56.3%25 identity in 245 aa overlap)%2C and sip4 (E(): 1.1e-09%2C 35.9%25 identity in 223 aa overlap). Note that after aa 325 the ORF overlaps the downstream sip3 gene SC2E1.15%2C and positional base preference suggests that translation is in the other frame. No error in the cosmid sequence can be found to account for this. Contains possible hydrophobic membrane spanning region gene gene5658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5597 SCO5598 SCO5598 sip3 sip3 6101641 6102651 + signal peptidase I SC2E1.15%2C sip3%2C probable signal peptidase I%2C len: 336 aa%3B identical to%2C but longer than%2C S. lividans Sip TR:E1228248 (EMBL:Y09474) signal peptidase I (291 aa)%2C fasta scores%3B opt: 1997 z-score: 2287.4 E(): 0%2C 99.7%25 identity in 291 aa overlap%2C and similar to many others e.g. LEP_PHOLA signal peptidase I (EC 3.4.21.89) (203 aa)%2C fasta scores%3B opt:222 z-score: 404.9 E(): 2.6e-15%2C 37.9%25 identity in 232 aa overlap. Contains PS00761 Signal peptidases I signature 3%2C 2x Pfam match to entry signal_pept_I PF00461%2C Signal peptidases I%2C scores 48.83 and 46.79 and probable transmembrane domain. Also similar to surrounding genes sip1 (E(): 7.6e-20%2C 35.6%25 identity in 264 aa overlap)%2C sip2 (E(): 0%2C 56.3%25 identity in 245 aa overlap) and sip4 (E(): 6.6e-15%2C 36.3%25 identity in 237 aa overlap). Note that a more upstream start was chosen due to positional base preference. Contains possible hydrophobic membrane spanning regions gene gene5659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5598 SCO5599 SCO5599 sip4 sip4 6102756 6103532 + signal peptidase I SC2E1.16%2C sip4%2C probable signal peptidase I%2C len: 258 aa%3B similar to many e.g. LEPS_BACSU signal peptidase I (EC 3.4.21.89) (184 aa)%2C fasta scores%3B opt: 258 z-score: 337.6 E(): 1.4e-11%2C 32.2%25 identity in 177 aa overlap. Contains Pfam match to entry signal_pept_I PF00461%2C Signal peptidases I%2C score 49.57 and probable transmembrane domain. Also similar to upstream genes sip1 (E(): 8.8e-10%2C 36.5%25 identity in 219 aa overlap)%2C sip2 (E(): 3.8e-13%2C 35.9%25 identity in 223 aa overlap) and sip3 (E(): 8.1e-15%2C 35.4%25 identity in 237 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene5660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5599 SCO5600 SCO5600 SC2E1.17 SC2E1.17 6103534 6104052 + hypothetical protein SC2E1.17%2C unknown%2C len: 172 aa%3B similar to C-terminus of M. tuberculosis hypothetical protein TR:O06205 (EMBL:Z95387) MTCY1A10.24 (351 aa)%2C fasta scores%3B opt: 345 z-score: 375.2 E(): 1.2e-13%2C 44.7%25 identity in 161 aa overlap. Contains PS00893 mutT domain signature and Pfam match to entry mutT PF00293%2C Bacterial mutT protein%2C score 37.78 gene gene5661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5600 SCO5601 SCO5601 SC2E1.18 SC2E1.18 6104109 6104417 + hypothetical protein SC2E1.18%2C unknown%2C len: 102 aa%3B highly similar to M. tuberculosis hypothetical protein YX32_MYCTU MTCY274.32c (101 aa)%2C fasta scores%3B opt: 515 z-score: 1085.2 E(): 0%2C 75.0%25 identity in 100 aa overlap gene gene5662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5601 SCO5602 SCO5602 SC2E1.19 SC2E1.19 6104476 6104868 + hypothetical protein SC2E1.19%2C unknown%2C len: 130 aa%3B similar to M. tuberculosis hypothetical protein YX29_MYCTU MTCY274.29c (128 aa)%2C fasta scores%3B opt: 253 z-score: 276.8 E(): 3.5e-08%2C 39.7%25 identity in 121 aa overlap gene gene5663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5602 SCO5603 SCO5603 SC2E1.20 SC2E1.20 6104868 6106493 + hypothetical protein SC2E1.20%2C unknown ATP/GTP binding protein%2C len: 541 aa%3B similar to hypothetical proteins from many organisms e.g. YIFB_ECOLI (516 aa)%2C fasta scores%3B opt: 356 z-score: 935.9 E(): 0%2C 37.0%25 identity in 513 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5603 SCO5604 SCO5604 SC2E1.21 SC2E1.21 6106490 6107638 + hypothetical protein SC2E1.21%2C unknown%2C len: 382 aa%3B N-terminus is Gly-rich%2C C-terminus is similar to the N-terminus of several hypothetical proteins e.g. SW:SMF_ECOLI SMF protein (374 aa)%2C fasta scores%3B opt: 402 z-score: 277.5 E(): 3.2e-08%2C 40.7%25 identity in 194 aa overlap. This ORF appears to be interrupted by the following prophage at around aa 360%2C and to continue as the last part of SC2E1.37. The similarity to the M. tuberculosis hypothetical protein SW:YX27_MYCTU MTCY274.27c (389 aa) (fasta scores%3B opt: 603 z-score: 511.5 E(): 3e-21%2C 46.8%25 identity in 267 aa overlap) stops at that position and restarts in SC2E1.37. Alternative start site at aa 118 sugested by positional base preference gene gene5665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5604 SCO5605 SCO5605 SC2E1.22 SC2E1.22 6107817 6108128 + hypothetical protein SC2E1.22%2C unknown prophage gene%2C len: 103 aa gene gene5666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5605 SCO5606 SCO5606 SC2E1.23c SC2E1.23c 6108125 6108415 - hypothetical protein SC2E1.23c%2C unknown prophage gene%2C len: 96 aa gene gene5667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5606 SCO5607 SCO5607 SC2E1.24 SC2E1.24 6108466 6108660 + transcriptional regulator SC2E1.24%2C possible prophage transcriptional regulator%2C len:64 aa%3B similar to the N-terminus of several regulatory proteins e.g. Streptomyces phaeochromogenes plasmid pJV1 TR:Q54677 (EMBL:U23762) traR (245 aa)%2C fasta scores%3B opt:137 z-score: 268.5 E(): 1e-07%2C 39.3%25 identity in 61 aa overlap. Contains Pfam match to entry gntR PF00392%2C Bacterial regulatory proteins%2C gntR family%2C score 43.92 gene gene5668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5607 SCO5608 SCO5608 SC2E1.25 SC2E1.25 6108755 6109456 + hypothetical protein SC2E1.25%2C unknown prophage gene%2C len: 233 aa. Contains possible hydrophobic membrane spanning regions gene gene5669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5608 SCO5609 SCO5609 SC2E1.26c SC2E1.26c 6109515 6109712 - hypothetical protein SC2E1.26c%2C unknown prophage gene%2C len: 65 aa%3B very hydrophobic. Contains possible hydrophobic membrane spanning region gene gene5670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5609 SCO5610 SCO5610 SC2E1.27c SC2E1.27c 6110051 6110413 - hypothetical protein SC2E1.27c%2C unknown prophage gene%2C len: 120 aa%3B contains hydrophobic region near centre. Contains possible hydrophobic membrane spanning region gene gene5671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5610 SCO5611 SCO5611 SC2E1.28 SC2E1.28 6111177 6111392 + transcriptional regulator SC2E1.28%2C possible prophage transcriptional regulator%2C len: 71 aa%3B similar to the N-terminus of many e.g. TR:Q37946 Salmonella typhimurium bacteriophage L repressor protein C2 (220 aa)%2C fasta scores%3B opt: 127 z-score: 227.1 E():2e-05%2C 45.7%25 identity in 46 aa overlap. Contains probable helix-turn-helix motif at aa 21 to 42 (Score 1829%2C +5.42 SD) gene gene5672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5611 SCO5612 SCO5612 SC2E1.29 SC2E1.29 6111554 6113824 + ATP binding protein SC2E1.29%2C unknown prophage ATP binding protein%2C len: 756 aa%3B some similarity to TR:Q38030 (EMBL:X76288) Streptomyces Bacteriophage phi-C31 early region ORF9 (519 aa)%2C fasta scores%3B opt: 360 z-score: 374.4 E(): 1.3e-13%2C 24.4%25 identity in 553 aa overlap%2C and to a prophage ORF from M. tuberculosis TR:O06608 (EMBL:Z95586) MTCY336.22 (471 aa)%2C fasta scores%3B opt: 655 z-score: 535.5 E(): 1.4e-22%2C 29.8%25 identity in 416 aa overlap. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5612 SCO5613 SCO5613 SC2E1.30 SC2E1.30 6114108 6114659 + hypothetical protein SC2E1.30%2C unknown prophage gene%2C len: 183 aa gene gene5674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5613 SCO5614 SCO5614 SC2E1.31 SC2E1.31 6115124 6115315 + transcriptional regulator SC2E1.31%2C possible prophage transcriptional regulator%2C len: 63 aa%3B similar to the N-terminus of many e.g. TR:E264367 (EMBL:X87420) Salmonella typhimurium bacteriophage ES18 gene C2 (216 aa)%2C fasta scores%3B opt: 133 z-score: 207.9E(): 0.00024%2C 35.8%25 identity in 53 aa overlap. Contains probable helix-turn-helix motif at aa 17 to 38 (Score 1786%2C +5.27 SD) gene gene5675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5614 SCO5615 SCO5615 SC2E1.32 SC2E1.32 6115312 6115662 + hypothetical protein SC2E1.32%2C unknown prophage gene%2C len: 116 aa gene gene5676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5615 SCO5616 SCO5616 SC2E1.33 SC2E1.33 6115730 6116218 + hypothetical protein SC2E1.33%2C unknown prophage gene%2C len: 162 aa%3B contains probable helix-turn-helix motif at aa 11 to 32 (Score 1192%2C +3.25 SD) gene gene5677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5616 SCO5617 SCO5617 SC2E1.34 SC2E1.34 6116205 6116621 + hypothetical protein SC2E1.34%2C unknown prophage gene%2C len: 138 aa gene gene5678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5617 SCO5618 SCO5618 SC2E1.35 SC2E1.35 6117039 6117482 + hypothetical protein SC2E1.35%2C unknown prophage gene%2C len: 147 aa gene gene5679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5618 SCO5619 SCO5619 SC2E1.36 SC2E1.36 6117794 6118300 + hypothetical protein SC2E1.36%2C unknown prophage gene%2C len: 168 aa gene gene5680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5619 SCO5620 SCO5620 SC2E1.37 SC2E1.37 6118370 6120760 + recombinase SC2E1.37%2C unknown prophage gene%2C len: 796 aa%3B shows very limited similarity to Rhodococcus opacus TR:G2935035 (EMBL:AF003948) transposase homolog (242 aa)%2C fasta scores%3B opt: 215 z-score: 280.3 E(): 2.2e-08%2C 33.3%25 identity in 105 aa overlap%3B and similar to TR:O69933 (EMBL:AL023861) Streptomyces coelicolor DNA recombinase SC3C8.24%2C 672 aa%3B fasta scores: opt: 1276 Z-score: 1340.7 bits: 258.7 E(): 4.8e-67%3B 41.074%25 identity in 689 aa overlap. Contains PS00397 Site-specific recombinases active site and Pfam match to entry recombinase PF00239%2C Site-specific recombinases%2C score 36.16. The last part of this ORF (aa 672 onwards) appears to be a continuation of SC2E1.21%2C which was interrupted by the prophage%3B the similarities to YX27_MYCTU MTCY274.27c (389 aa) (fasta scores%3B opt: 246 z-score: 225.9 E(): 2.4e-05%2C 38.8%25 identity in 116 aa overlap) continue after aa 672. Contains probable coiled-coil from aa 449 to 505 gene gene5681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5620 SCO5621 SCO5621 SC2E1.38 SC2E1.38 6121043 6121885 + RNA polymerase sigma factor WhiG involved in the initiation of sporulation and glycogen biosynthesis gene gene5682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5621 SCO5622 SCO5622 SC2E1.39 SC2E1.39 6122014 6122571 + transcriptional regulator SC2E1.39%2C possible transcriptional regulator%2C len: 185 aa%3B equivalent to Streptomyces roseosporus TR:P72569 (EMBL:U58281) tetR homologue WhiR (179 aa) (86.6%25 identity in 179 aa overlap) and similar to several transcriptional regulators of the tetR family e.g. TR:E1247678 transcriptional regulator SC10A5.11 (S.coelicolor) (198 aa)%2C fasta scores%3B opt: 434 z-score: 720.5 E(): 6.8e-33%2C 41.5%25 identity in 171 aa overlap. Contains probable helix-turn-helix motif at aa 29 to 50 (Score 1618%2C +4.70 SD) and Pfam match to entry tetR PF00440%2C Bacterial regulatory proteins%2C tetR family%2C score 29.18 gene gene5683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5622 SCO5623 SCO5623 SC2E1.40c SC2E1.40c 6122525 6123205 - hypothetical protein SC2E1.40c%2C probable hypothetical protein%2C len: 226 aa%3B some similarity to two M. tuberculosis proteins YX22_MYCTU MTCY274.22 (249 aa)%2C fasta scores%3B opt: 315 z-score: 268.8 E(): 9.7e-08%2C 40.7%25 identity in 145 aa overlap (also upstream of rpsB) and Y0GK_MYCTU MTCY13D12.20 (407 aa)%2C fasta scores%3B opt: 218 z-score: 176.1 E(): 0.014%2C 34.1%25 identity in 164 aa overlap. Contains probable N-terminal signal sequence. gene gene5684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5623 SCO5624 SCO5624 rpsB rpsB 6123494 6124426 + 30S ribosomal protein S2 one of the last subunits in the assembly of the 30S subunit%3B absence of S2 does not inhibit assembly but results in an inactive subunit gene gene5685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5624 SCO5625 SCO5625 tsf tsf 6124521 6125357 + elongation factor Ts EF-Ts%3B functions during elongation stage of protein translation%3B forms a dimer%3B associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu gene gene5686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5625 SCO5626 SCO5626 pyrH pyrH 6125563 6126324 + uridylate kinase Catalyzes the phosphorylation of UMP to UDP gene gene5687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5626 SCO5627 SCO5627 frr frr 6126503 6127060 + ribosome recycling factor Rrf%3B Frr%3B ribosome-recycling factor%3B release factor 4%3B RF4%3B recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G%3B A GTPase-dependent process results in release of 50S from 70S%3B inhibited by release factor RF-1%3B essential for viability%3B structurally similar to tRNAs gene gene5688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5627 SCO5628 SCO5628 SC6A9.39c SC6A9.39c 6127060 6128235 + hypothetical protein SC6A9.39c%2C probable integral membrane protein%2C len: 391 aa%3B C-terminus is similar to many phosphatidate cytidylyltransferases e.g. SW:CDSA_ECOLI (EMBL:M11330) phosphatidate cytidylyltransferase (249 aa)%2C fasta scores%3B opt: 379 z-score: 384.3 E(): 3.6e-14%2C 38.8%25 identity in 196 aa overlap gene gene5689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5628 SCO5629 SCO5629 SC6A9.38 SC6A9.38 6128360 6131020 - ATP /GTP-binding protein SC6A9.38%2C unknown ATP /GTP-binding protein%2C len: 886 aa%3B C-terminus contains 7 x 42 aa repeats with weak similarity to eukaryotic kinesin light chain 42 aa repeats e.g. KNLC_LOLPE kinesin light chain (klc) (571 aa)%2C fasta scores%3B opt: 302 z-score: 260.7 E(): 2.8e-07%2C 24.0%25 identity in 405 aa overlap. Contains PS00017 ATP/GTP- binding gene gene5690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5629 SCO5630 SCO5630 SC6A9.36 SC6A9.36 6131534 6132414 - gene gene5691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5630 SCO5632 SCO5632 SC6A9.35 SC6A9.35 6132437 6132679 - hypothetical protein SC6A9.35%2C unknown%2C len: 80 aa gene gene5692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5632 SCO5633 SCO5633 SC6A9.34 SC6A9.34 6133491 6135797 - traSA:integrase fusion protein SC6A9.34%2C probable fusion protein partially within integrated plasmid%2C len: 259 aa%3B N-terminus is almost identical to TR:E1286466 (EMBL:AJ005260) plasmid transfer protein traSA from Streptomyces ambofaciens plasmid pSAM2 (415 aa)%3B 96.2%25 identity in 369 aa overlap%2C and similar to other members of the spoIIIE /ftsK family e.g. SPI_STRAZ sporulation-regulatory protein (303 aa)%2C fasta scores%3B opt: 608 z-score: 904.0 E(): 0%2C 57.0%25 identity in 235 aa overlap. C-terminus is similar to many integrase /recombinases e.g. TR:O55248 (EMBL:AF030986) Mycobacterium phage MS6 integrase (372 aa)%2C fasta scores%3B opt: 184 z-score: 323.4 E(): 8.9e-11%2C 26.4%25 identity in 364 aa overlap. N-terminus contains TTA Leu codon%3B possible target for action of bldA and PS00017 ATP /GTP-binding%3D Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family%2C score 40.60%2C E-value 3.5e-08 gene gene5693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5633 SCO5634 SCO5634 SC6A9.32 SC6A9.32 6135554 6136151 - gene gene5694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5634 SCO5636 SCO5636 korSA korSA 6136289 6137068 - transcriptional regulator SC6A9.31%2C korSA%2C transcriptional regulator%2C len: 259 aa%3B almost identical to TR:E1286465 (EMBL:AJ005260) KorSA from Streptomyces ambofaciens plasmid pSAM2 (259 aa)%3B 98.5%25 identity in 259 aa overlap and similar to many members of the gntR family e.g. KORA_STRLI KorA protein (241 aa)%2C fasta scores%3B opt: 187 z-score: 247.3 E(): 1.6e-06%2C 26.7%25 identity in 240 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family%2C score 61.80%2C E-value 1.6e-17 gene gene5695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5636 SCO5637 SCO5637 SC6A9.30c SC6A9.30c 6137156 6137551 + mutT-like protein SC6A9.30c%2C mutT-like protein%2C len: 131 aa%3B almost identical to TR:E1286464 (EMBL:AJ005260) ORF131 from Streptomyces ambofaciens plasmid pSAM2 (131 aa)%3B 96.2%25 identity in 131 aa overlap%2C and similar to e.g. MUTT_PROVU mutator mutt protein (7%2C8-dihydro-8-oxoguanine-triphosphatase) (112 aa)%2C fasta scores%3B opt: 128 z-score: 217.1 E(): 7.4e-05%2C 41.8%25 identity in 55 aa overlap. Contains PS00893 mutT domain signature and Pfam match to entry PF00293 mutT%2C Bacterial mutT protein%2C score 58.30%2C E-value 3e-15 gene gene5696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5637 SCO5638 SCO5638 SC6A9.29 SC6A9.29 6137881 6138768 - hypothetical protein SC6A9.29%2C probable integral membrane protein%2C len: 295 aa%3B this ORF has atypically low GC bias in FramePlot gene gene5697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5638 SCO5639 SCO5639 SC6A9.28 SC6A9.28 6138765 6139295 - hypothetical protein SC6A9.28%2C unknown%2C len: 176 aa%3B this ORF has atypically low GC bias in FramePlot gene gene5698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5639 SCO5640 SCO5640 SC6A9.27 SC6A9.27 6139402 6139869 - hypothetical protein SC6A9.27%2C unknown%2C len: 155 aa%3B this ORF has atypically low GC bias in FramePlot gene gene5699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5640 SCO5641 SCO5641 SC6A9.26 SC6A9.26 6139887 6140843 - transposase SC6A9.26%2C probable transposase for IS1649%2C len: 318 aa%3B similar to many e.g. Corynebacterium striatum TR:O30997 (EMBL:AF024666) transposase TNP5564 (329 aa)%2C fasta scores%3B opt: 589 z-score: 1572.9 E(): 0%2C 50.0%25 identity in 330 aa overlap. Contains probable helix-turn-helix motif at aa 26-47 (Score 1176%2C +3.19 SD) gene gene5700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5641 SCO5642 SCO5642 SC6A9.25 SC6A9.25 6140819 6141583 - hypothetical protein SC6A9.25%2C unknown%2C len: 254 aa%3B this ORF has atypically low GC bias in FramePlot gene gene5701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5642 SCO5643 SCO5643 SC6A9.24 SC6A9.24 6141650 6142177 - hypothetical protein SC6A9.24%2C questionable ORF%2C len: 175 aa%3B this ORF has atypically low GC bias in FramePlot gene gene5702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5643 SCO5644 SCO5644 SC6A9.23c SC6A9.23c 6142261 6142887 + hypothetical protein SC6A9.23c%2C unknown%2C len: 208 aa%3B this ORF has atypically low GC bias in FramePlot gene gene5703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5644 SCO5645 SCO5645 SC6A9.22c SC6A9.22c 6143019 6144125 + 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN 23S rRNA m2A2503 methyltransferase%3B methylates the C2 position of the A2530 nucleotide in 23S rRNA%3B may be involved in antibiotic resistance gene gene5704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5645 SCO5646 SCO5646 SC6A9.21c SC6A9.21c 6144349 6145470 + solute binding lipoprotein SC6A9.21c%2C probable solute binding lipoprotein%2C len: 373 aa%3B similar to e.g. TBPA_ECOLI thiamin-binding periplasmic protein (327 aa)%2C fasta scores%3B opt: 220 z-score: 423.3 E(): 2.4e-16%2C 28.4%25 identity in 327 aa overlap. Contains N-terminla signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5646 SCO5647 SCO5647 SC6A9.20c SC6A9.20c 6145467 6147128 + ABC transporter SC6A9.20c%2C probable ABC transporter integral membrane protein%2C len: 553 aa%3B similar to many e.g. Y4FN_RHISN probable ABC transporter permease (569 aa)%2C fasta scores%3B opt: 296 z-score: 555.5 E(): 1e-23%2C 25.4%25 identity in 563 aa overlap. Contains 2x Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C scores 40.70%2C E-value 3.2e-08 and 46.50%2C E-value 6.1e-10 gene gene5706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5647 SCO5648 SCO5648 SC6A9.19c SC6A9.19c 6147131 6148177 + ABC transporter ATP-binding protein SC6A9.19c%2C probable ABC transporter ATP binding protein%2C len: 348 aa%3B similar to many e.g. POTA_ECOLI spermidine /putrescine transport ATP-binding protein (378 aa)%2C fasta scores%3B opt: 715 z-score: 832.8 E(): 0%2C 42.5%25 identity in 308 aa overlap. Contains PS00017 ATP /GTP-binding%3D transporters family signature and Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 226.00%2C E-value 5.5e-64 gene gene5707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5648 SCO5649 SCO5649 SC6A9.18c SC6A9.18c 6148202 6149002 + hypothetical protein SC6A9.18c%2C unknown%2C len: 266 aa%3B similar to M. tuberculosis hypothetical protein TR:O07256 (EMBL:Z96800) MTCY63.37 (261 aa)%2C fasta scores%3B opt: 508 z-score: 606.3 E(): 1.6e-26%2C 36.7%25 identity in 251 aa overlap gene gene5708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5649 SCO5650 SCO5650 SC6A9.17 SC6A9.17 6149064 6149768 - hypothetical protein SC6A9.17%2C possible membrane protein%2C len: 234 aa. Contains possible hydrpphobic membrane spanning regions gene gene5709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5650 SCO5651 SCO5651 SC6A9.16 SC6A9.16 6149925 6151109 - hypothetical protein SC6A9.16%2C unknown%2C len: 394 aa gene gene5710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5651 SCO5652 SCO5652 SC6A9.15 SC6A9.15 6151136 6151543 - hypothetical protein SC6A9.15%2C conserved hypothetical protein%2C len: 135 aa%3B similar to TR:Q98D71 (EMBL:AP003005) hypothetical protein from Rhizobium loti (134 aa) fasta scores%3B opt: 401%2C Z-score: 482.3%2C E(): 3.1e-19%2C 46.212%25 identity (46.565%25 ungapped) in 132 aa overlap. gene gene5711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5652 SCO5653 SCO5653 SC6A9.14 SC6A9.14 6151649 6153109 - hypothetical protein SC6A9.14%2C probable integral membrane protein%2C len: 486 aa%3B contains Pro- Ala- rich central region gene gene5712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5653 SCO5654 SCO5654 SC6A9.13 SC6A9.13 6153091 6153867 - ABC transporter ATP-binding protein SC6A9.13%2C probable ABC transporter ATP-binding protein%2C len: 258 aa%3B similar to many e.g. YBBA_ECOLI hypothetical ABC transporter ATP-binding protein (228 aa)%2C fasta scores%3B opt: 462 z-score: 578.7 E(): 5.3e-25%2C 40.4%25 identity in 198 aa overlap. Contains PS00017 ATP /GTP-binding%3D PF00005 ABC_tran%2C ABC transporters%2C score 173.20%2C E-value 4.2e-48 gene gene5713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5654 SCO5655 SCO5655 SC6A9.12 SC6A9.12 6154073 6155446 - hypothetical protein SC6A9.12%2C probable aminotransferase%2C len: 457 aa%3B similar to many e.g. BIOA_BACSU adenosylmethionine-8-amino-7-oxononanoate aminotransferase (448 aa)%2C fasta scores%3B opt: 895 z-score: 881.6 E(): 0%2C 35.6%25 identity in 449 aa overlap. Also highly similar to M. tuberculosis aminotransferase TR:O53379 (EMBL:AL021841) MTV016.29%3B 70.3%25 identity in 438 aa overlap. Contains Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate%2C score 355.70%2C E-value 3.5e-123 gene gene5714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5655 SCO5656 SCO5656 SC6A9.11 SC6A9.11 6155449 6155949 - transcriptional regulator SC6A9.11%2C probable transcriptional regulatory protein%2C len: 166 aa%3B similar to many members of the asnC family e.g. LRP_ECOLI leucine-responsive regulatory protein (164 aa)%2C fasta scores%3B opt: 190 z-score: 294.3 E(): 3.7e-09%2C 27.6%25 identity in 156 aa overlap. Contains PS00519 Bacterial regulatory proteins%2C asnC family signature and probable helix-turn-helix motif at aa 39-60 (Score 1545%2C +4.45 SD) gene gene5715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5656 SCO5657 SCO5657 SC6A9.10c SC6A9.10c 6156130 6157569 + aldehyde dehydrogenase SC6A9.10c%2C probable aldehyde dehydrogenase%2C len: 479 aa%3B similar to many e.g. DHAB_BACSU betaine aldehyde dehydrogenase (EC 1.2.1.8) (490 aa)%2C fasta scores%3B opt: 1131 z-score: 1242.7 E(): 0%2C 39.2%25 identity in 472 aa overlap. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site%2C PS00070 Aldehyde dehydrogenases cysteine active site and Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenases%2C score 598.80%2C E-value 3.2e-176 gene gene5716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5657 SCO5658 SCO5658 SC6A9.09c SC6A9.09c 6157741 6158940 + polyamine-binding lipoprotein SC6A9.09c%2C possible polyamine-binding lipoprotein%2C len: 399 aa%3B some similarity to several spermidine /putrescine /putrescine-binding%3D scores%3B opt: 389 z-score: 352.1 E(): 2.2e-12%2C 26.9%25 identity in 349 aa overlap. Contains N-terminal siganl sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5658 SCO5659 SCO5659 SC6A9.08c SC6A9.08c 6158953 6159492 + hypothetical protein SC6A9.08c%2C possible integral membrane protein%2C len: 179 aa%3B contains four possible transmembrane domains gene gene5718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5659 SCO5660 SCO5660 SC6A9.07 SC6A9.07 6159509 6160669 - peptidase SC6A9.07%2C probable peptidase%2C len: 386 aa%3B similar to e.g. DAC_STRSQ D-alanyl-D-alanine carboxypeptidase precursor (406 aa)%2C fasta scores%3B oopt: 544 z-score: 500.9 E(): 1.2e-20%2C 33.2%25 identity in 365 aa overlap. Contains N-terminal signal sequence and PS00017 ATP /GTP-binding site motif A (P-loop) gene gene5719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5660 SCO5661 SCO5661 SC6A9.06 SC6A9.06 6160823 6161548 - hypothetical protein SC6A9.06%2C unknown%2C len: 241 aa%3B similar to hypothetical proteins e.g. Bacillus subtilis TR:O07592 (EMBL:Y14082) YhdW (243 aa)%2C fasta SCORES%3B opt: 144 z-score: 267.8 E(): 1.1e-07%2C 25.0%25 identity in 236 aa overlap gene gene5720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5661 SCO5662 SCO5662 SC6A9.05 SC6A9.05 6161552 6162715 - adenosine deaminase catalyzes the formation of inosine from adenosine gene gene5721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5662 SCO5663 SCO5663 SC3A9.04c SC3A9.04c 6162772 6163452 + hypothetical protein SC3A9.04c%2C probable integral membrane protein%2C len: 226 aa%3B has highly proline-rich N-terminus and two possible transmembrane domains in the C-terminus. Similar to downstream ORF SC3A9.03c%2C fasta scores%3B E(): 6.5e-06%2C 41.0%25 identity in 134 aa overlap gene gene5722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5663 SCO5664 SCO5664 SC3A9.03c SC3A9.03c 6163511 6163960 + hypothetical protein SC3A9.03c%2C probable integral membrane protein%2C len: 149 aa%3B has Pro-%2C Gly-rich N-terminus and two possible transmembrane domains in the C-terminus%3B some similarity to M. tuberculosis hypothetical protein TR:E1264549 (EMBL:AL022121) MTV025.037 (451 aa)%2C fasta scores%3B opt: 183 z-score: 182.2 E(): 0.0066%2C 33.1%25 identity in 145 aa overlap. Also similar to upstream gene SC3A9.04c%2C fasta scores%3B E(): 1.5e-06%2C 41.0%25 identity in 134 aa overlap gene gene5723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5664 SCO5665 SCO5665 SC6A9.02 SC6A9.02 6164022 6164663 - hypothetical protein SC6A9.02%2C unknown%2C len: 213 aa%3B some similarity to several hypothetical proteins from Caenorhabditis elegans e.g. TR:G3168942 (EMBL:AF068713) T24A6.7 (206 aa)%2C fasta scores%3B opt: 256 z-score: 328.5 E(): 4.7e-11%2C 31.2%25 identity in 154 aa overlap gene gene5724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5665 SCO5666 SCO5666 SC6A9.01c SC6A9.01c 6164842 6166377 + gamma-aminobutyraldehyde dehydrogenase catalyzes the formation of 4-aminobutanoate from 4-aminobutanal%3B involved in putrescine degradation gene gene5725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5666 SCO5667 SCO5667 SC8B7.11c SC8B7.11c 6166490 6167689 + ABC transporter substrate-binding protein SC8B7.11c%2C probable ABC-transporter polyamine-binding lipoprotein%2C len: 399 aa%3B similar to e.g. POTF_ECOLI putrescine-binding periplasmic protein precursor (370 aa)%2C fasta scores%3B opt: 327 z-score: 259.5 E(): 3.4e-07%2C 28.5%25 identity in 365 aa overlap. Also similar to upstream gene SC6A9.09c (E(): 0%2C 46.8%25 identity in 391 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible N-terminal region signal sequence peptide gene gene5726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5667 SCO5668 SCO5668 SC8B7.10c SC8B7.10c 6167695 6168888 + polyamine ABC transporter ATP-binding protein SC8B7.10c%2C probable polyamine ABC-transporter ATP-bi nding protein%2C len: 397 aa%3B similar to many e.g. POTA_ECOLI spermidine/putrescine transport ATP-binding (378 aa)%2C fast a scores%3B opt: 933 z-score: 1101.5 E(): 0%2C 47.7%25 identity i n 325 aa overlap. Contains PS00017 ATP/GTP-binding site mot if A (P-loop)%2C PS00211 ABC transporters family signature an d Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C s core 216.70%2C E-value 3.6e-61 gene gene5727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5668 SCO5669 SCO5669 SC8B7.09c SC8B7.09c 6168888 6169817 + polyamine ABC-transporter integral memb rane protein SC8B7.09c%2C probable polyamine ABC-transporter integr al membrane protein%2C len: 309 aa%3B similar to many e.g. POTB _ECOLI spermidine/putrescine transport system permease (275 aa)%2C fasta scores%3B opt: 548 z-score: 685.1 E(): 6.6e-31%2C 3 6.9%25 identity in 274 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 38.20%2C E-value 1.8e -07 gene gene5728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5669 SCO5670 SCO5670 SC8B7.08c SC8B7.08c 6169818 6170618 + polyamine ABC-transporter integral memb rane protein SC8B7.08c%2C probable polyamine ABC-transporter integr al membrane protein%2C len: 266 aa%3B similar to many e.g. POTC _ECOLI spermidine/putrescine transport system permease (264 aa)%2C fasta scores%3B opt: 579 z-score: 718.8 E(): 8.8e-33%2C 3 5.5%25 identity in 251 aa overlap. Contains Pfam match to ent ry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 23.00%2C E-value 0.00 7 gene gene5729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5670 SCO5671 SCO5671 SC8B7.07c SC8B7.07c 6170654 6172081 + oxidoreductase SC8B7.07c%2C possible oxidoreductase%2C len: 475 aa%3B some similarity to e.g. ORDL_ECOLI probable oxidoreductase ord L (426 aa)%2C fasta scores%3B opt: 413 z-score: 280.3 E(): 2.4 e-08%2C 32.1%25 identity in 436 aa overlap gene gene5730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5671 SCO5672 SCO5672 SC8B7.06c SC8B7.06c 6172204 6172662 + hypothetical protein SC8B7.06c%2C unknown%2C len: 152 aa gene gene5731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5672 SCO5673 SCO5673 chiB chiB 6172804 6174636 + chitinase SC8B7.05c%2C chiB%2C chitinase%2C len: 610 aa%3B almost identical to S. lividans TR:D1026067 (EMBL:D84193) chitinase ChiB (EC 3.2.1.14) (610 aa)%2C 99.3%25 identity in 610 aa overlap%2C and highly similar to many e.g. CHIX_STROI Streptomyces olivaceoviridis exochitinase 1 precursor (EC 3.2.1.14) ( 597 aa)%2C fasta scores%3B opt: 3484 z-score: 2485.6 E(): 0%2C 86.1%25 identity in 596 aa overlap. Contains PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence gene gene5732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5673 SCO5674 SCO5674 SC8B7.04 SC8B7.04 6174575 6175318 - hypothetical protein SC8B7.04%2C probable integral membrane protein%2C len: 247 aa. Contains possible hydrophobic membrane spanning regions gene gene5733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5674 SCO5675 SCO5675 SC8B7.03c SC8B7.03c 6175387 6176157 + hypothetical protein SC8B7.03c%2C unknown%2C len: 256 aa gene gene5734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5675 SCO5676 SCO5676 gabT gabT 6176557 6177891 - 4-aminobutyrate aminotransferase catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate gene gene5735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5676 SCO5677 SCO5677 SC5H4.01 SC5H4.01 6178250 6180280 + ATP/GTP binding protein SC5H4.01%2C possible ATP/GTP binding protein ( membrane protein) (fragment)%2C len: >350 aa~SC8B7.01c%2C probable ATP/GTP binding protein (membrane protein)%2C partial CDS%2C len: >604 aa. Contains PS00017 ATP/GTP-binding site m otif A (P-loop)%2C and two possible transmembrane domains at C-terminus gene gene5736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5677 SCO5678 SCO5678 SC5H4.02 SC5H4.02 6180444 6182102 + regulatory protein SC5H4.02%2C possible regulatory protein%2C len: 552 aa%3B similar to TR:Q9ZBP0 (EMBL:AL034492) Streptomyces coelicolor regulatory protein SC6C5.05c%2C 569 aa%3B fasta scores: opt: 310 z-score: 323.3 E(): 1.5e-10%3B 30.0%25 identity in 587 aa overlap gene gene5737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5678 SCO5679 SCO5679 SC5H4.03 SC5H4.03 6182246 6183691 + aldehyde dehydrogenase SC5H4.03%2C probable aldehyde dehydrogenase%2C len: 481 aa%3B similar to TR:O66573 (EMBL:AE000677) Aquifex aeolicus aldehyde dehydrogenase AldH1%2C 476 aa%3B fasta scores: opt: 1129 z-score: 1260.2 E(): 0%3B 39.9%25 identity in 471 aa overlap and to SW:GAPN_STRMU (EMBL:L38521) Streptococcus mutans NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9) GapN%2C 475 aa%3B fasta scores: opt: 893 z-score: 997.5 E(): 0%3B 35.4%25 identity in 477 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family gene gene5738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5679 SCO5680 SCO5680 SC5H4.04c SC5H4.04c 6183701 6184114 - cytidine deaminase SC5H4.04c%2C probable cytidine deaminase%2C len: 137 aa%3B similar to TR:O53367 (EMBL:AL021841) Mycobacterium tuberculosis cytidine deaminase Cdd%2C 133 aa%3B fasta scores: opt 185 z-score: 244.6 E(): 3.6e-06%3B 37.4%25 identity in 115 aa overlap and to SW:CDD_MOUSE (EMBL:AA388666) Mus musculus cytidine deaminase (EC 3.5.4.5) Cdd%2C 146 aa%3B fasta scores: opt: 173 z-score: 229.1 E(): 2.6e-05%3B 29.2%25 identity in 113 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam%2C Cytidine and deoxycytidylate deaminase zinc-binding region and match to Prosite entry PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature gene gene5739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5680 SCO5681 SCO5681 SC5H4.05c SC5H4.05c 6184140 6185315 - glycosyl transferase SC5H4.05c%2C possible glycosyl transferase%2C len: 391 aa%3B similar to TR:Q9X7Z1 (EMBL:AL049497) Streptomyces coelicolor glycosyl transferase SC6G10.05c%2C 412 aa%3B fasta scores: opt: 1364 z-score: 1557.1 E(): 0%3B 56.4%25 identity in 385 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1 gene gene5740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5681 SCO5682 SCO5682 SC5H4.06c SC5H4.06c 6185312 6186445 - hypothetical protein SC5H4.06c%2C possible integral membrane protein%2C len: 377 aa%3B similar to TR:Q53873 (EMBL:AL031317) Streptomyces coelicolor integral membrane protein SC6G4.11%2C 411 aa%3B fasta scores: opt: 180 z-score: 193.2 E(): 0.0027%3B 33.8%25 identity in 340 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5682 SCO5683 SCO5683 SC5H4.07 SC5H4.07 6186588 6187784 + two-component system sensor kinase SC5H4.07%2C probable two-component system sensor kinase%2C len: 398 aa%3B similar to TR:Q9X851 (EMBL:AL049630) Streptomyces coelicolor two-component sensor kinase SCE126.08c%2C 401 aa%3B fasta scores: opt: 581 z-score: 640.5 E(): 3.2e-28%3B 36.8%25 identity in 361 aa overlap and to TR:BAA88406 (EMBL:AB016841) Streptomyces thermoviolaceus ChiS protein%2C 448 aa%3B fasta scores: opt: 445 z-score: 491.3 E(): 6.6e-20%3B 34.5%25 identity in 391 aa overlap. Contains possible hydrophobic membrane spanning regions in N-terminal domain gene gene5742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5683 SCO5684 SCO5684 SC5H4.08 SC5H4.08 6187781 6188494 + two-component system response regulator SC5H4.08%2C probable two-component system response regulator%2C len: 237 aa%3B similar to TR:Q9X8Q7 (EMBL:AL049754) Streptomyces coelicolor two-component system regulator SCH10.18c%2C 228 aa%3B fasta scores: opt: 780 z-score: 922.5 E(): 0%3B 58.7%25 identity in 225 aa overlap and to TR:BAA88407 (EMBL:AB016841) Streptomyces thermoviolaceus ChiR protein%2C 213 aa%3B fasta scores: opt: 567 z-score: 674.0 E(): 4.4e-30%3B 46.9%25 identity in 213 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature and also a possible helix-turn-helix motif at residues 180..201 (+2.70 SD) gene gene5743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5684 SCO5685 SCO5685 SC5H4.09c SC5H4.09c 6188536 6191418 - sugar hydrolase SC5H4.09c%2C probable sugar hydrolase%2C len: 960 aa%3B similar to TR:Q59506 (EMBL:L06134) Microbispora bispora glucan-glucohydrolase (EC 3.2.1.74) (glucan 1%2C4-beta-glucosidase) (exo-1%2C4-beta-glucosidase) BglA%2C 986 aa%3B fasta scores: opt: 1257 z-score: 1346.1 E(): 0%3B 47.7%25 identity in 979 aa overlap. Contains Pfam matches to entries PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3 N terminal domain and PF01915 Glyco_hydro_3_C%2C Glycosyl hydrolase family 3 C terminal domain gene gene5744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5685 SCO5686 SCO5686 SC5H4.10 SC5H4.10 6191668 6193353 + lipoprotein SC5H4.10%2C probable lipoprotein%2C len: 561 aa%3B similar to SW:LPLA_BACSU (EMBL:L03376) Bacillus subtilis LplA%2C 502 aa%3B fasta scores: opt: 364 z-score: 402.3 E(): 6e-15%3B 23.6%25 identity in 483 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C possible N-terminal region signal peptide sequence and possible colied-coil region at residues 562..575 gene gene5745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5686 SCO5687 SCO5687 SC5H4.11 SC5H4.11 6193381 6194421 + transport system integral membrane protein SC5H4.11%2C probable transport system integral membrane protein%2C len: 346 aa%3B similar to SW:LPLB_BACSU (EMBL:L19163) Bacillus subtilis LplB protein%2C 318 aa%3B fasta scores: opt: 814 z-score: 950.7 E(): 0%3B 38.2%25 identity in 309 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains also possible hydrophobic membrane spanning regions gene gene5746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5687 SCO5688 SCO5688 SC5H4.12 SC5H4.12 6194418 6195389 + transport system integral membrane protein SC5H4.12%2C probable transport system integral membrane protein%2C len: 323 aa%3B similar to SW:LPLC_BACSU (EMBL:L19164) Bacillus subtilis LplC%2C 295 aa%3B fasta scores: opt: 669 z-score: 758.9 E(): 0%3B 38.0%25 identity in 276 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains also possible hydrophobic membrane spanning regions gene gene5747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5688 SCO5689 SCO5689 SC5H4.13 SC5H4.13 6195389 6197359 + beta-galactosidase SC5H4.13%2C probable beta-galactosidase%2C len: 656 aa%3B similar to SW:BGAL_BACST (EMBL:M13466) Bacillus stearothermophilus beta-galactosidase I (EC 3.2.1.23) (lactase) BgaB%2C 672 aa%3B fasta scores: opt: 1761 z-score: 2065.7 E(): 0%3B 41.3%25 identity in 634 aa overlap and to TR:CAB76326 (EMBL:AL158061) Streptomyces coelicolor probable beta-galactosidase SC6D11.03c%2C 681 aa%3B fasta scores: opt: 1739 z-score: 1719.0 E(): 0%3B 46.0%25 identity in 670 aa overlap gene gene5748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5689 SCO5690 SCO5690 SC5H4.14 SC5H4.14 6197356 6199599 + hypothetical protein SC5H4.14%2C hypothetical protein%2C len: 747 aa%3B similar to TR:CAB36703 (EMBL:AL035521) Arabidopsis thaliana hypothetical 94.0 kD protein AT4G34260%2C 847 aa%3B fasta scores: opt: 322 z-score: 354.9 E(): 2.6e-12%3B 25.6%25 identity in 754 aa overlap gene gene5749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5690 SCO5691 SCO5691 SC5H4.15 SC5H4.15 6199638 6200372 + hypothetical protein SC5H4.15%2C probable sugar hydrolase%2C len: 244 aa%3B similar to SW:GUNS_ERWCA (EMBL:M32399) Erwinia carotovora endoglucanase S precursor (EC 3.2.1.4) (endo-1%2C4-beta-glucanase S) (cellulase S) CelS%2C 264 aa%3B fasta scores: opt: 283 z-score: 330.2 E(): 6.2e-11%3B 33.2%25 identity in 253 aa overlap. Contains Pfam match to entry PF01670 Glyco_hydro_12%2C Glycosyl hydrolase family 12 and possible N-terminal region signal peptide sequence gene gene5750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5691 SCO5692 SCO5692 SC5H4.16c SC5H4.16c 6200514 6201527 - transcriptional regulator SC5H4.16c%2C probable transcriptional regulator%2C len: 337 aa%3B similar to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR%2C 340 aa%3B fasta scores: opt: 440 z-score: 531.7 E(): 3.7e-22%3B 31.6%25 identity in 339 aa overlap. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins%2C lacI family signature. Contains also possible helix-turn-helix motif at residues 2..23 (+6.39 SD) gene gene5751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5692 SCO5693 SCO5693 SC5H4.17 SC5H4.17 6201820 6203796 + acyl CoA dehydrogenase SC5H4.17%2C probable acyl CoA dehydrogenase%2C len: 658 aa%3B similar to SW:ACDV_BOVIN (EMBL:U30817) Bos taurus acyl-CoA dehydrogenase%2C very-long-chain specific precursor (EC 1.3.99.-) VlcaD%2C 655 aa%3B fasta scores: opt: 768 z-score: 864.8 E(): 0%3B 31.0%25 identity in 616 aa overlap . Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase gene gene5752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5693 SCO5694 SCO5694 dxr dxr 6203922 6205178 + 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate gene gene5753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5694 SCO5695 SCO5695 SC5H4.19 SC5H4.19 6205187 6206479 + metalloprotease SC5H4.19%2C possible metalloprotease%2C len: 430 aa%3B similar to TR:O83609 (EMBL:AE001235) Treponema pallidum zinc protease%2C TP0600%2C 450 aa%3B fasta scores: opt: 181 z-score: 205.4 E(): 0.00056%3B 28.0%25 identity in 400 aa overlap. Contains Pfam match to entry PF00595 PDZ%2C PDZ domain (Also known as DHR or GLGF) and match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature and also possible hydrophobic membrane spanning regions gene gene5754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5695 SCO5696 SCO5696 ispG ispG 6206675 6207832 + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase catalyzes the conversion of 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate%3B involved in isoprenoid synthesis gene gene5755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5696 SCO5697 SCO5697 SC5H4.21 SC5H4.21 6208102 6208965 + hypothetical protein SC5H4.21%2C hypothetical protein%2C len: 287 aa%3B similar to TR:O33349 (EMBL:AL008883) Mycobacterium tuberculosis hypothetical 30.3 kD protein MTV003.13c%2C 284 aa%3B fasta scores: opt: 798 z-score: 942.8 E(): 0%3B 48.0%25 identity in 269 aa overlap gene gene5756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5697 SCO5698 SCO5698 SC5H4.22 SC5H4.22 6209024 6209566 + hypothetical protein SC5H4.22%2C hypothetical protein%2C len: 180 aa%3B similar to TR:O69563 (EMBL:AL022602) Mycobacterium leprae hypothetical 23.9 kD protein MLCB268.13%2C 210 aa%3B fasta scores: opt: 243 z-score: 313.1 E(): 5.6e-10%3B 29.1%25 identity in 203 aa overlap gene gene5757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5698 SCO5699 SCO5699 proS proS 6209640 6211343 + prolyl-tRNA synthetase catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) gene gene5758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5699 SCO5700 SCO5700 SC5H4.24c SC5H4.24c 6211917 6212816 - kinase SC5H4.24c%2C probable kinase%2C len: 299 aa%3B similar to SW:STRA_STRGA (EMBL:X05648) Streptomyces glaucescens streptomycin 6-kinase (EC 2.7.1.72) Sph%2C 307 aa%3B fasta scores: opt: 446 z-score: 504.5 E(): 1.2e-20%3B 34.7%25 identity in 271 aa overlap. Contains possible helix-turn-helix motif at residues 249..270 (+2.59 SD) gene gene5759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5700 SCO5701 SCO5701 SC5H4.25c SC5H4.25c 6212856 6213359 - hypothetical protein SC5H4.25c hypothetical protein%2C len: 167 aa%3B similar to TR:O05815 (EMBL:Z95207) Mycobacterium tuberculosis hypothetical 16.9 kDp protein MTCY24A1.13c%2C 162 aa%3B fasta scores: opt: 242 z-score: 266.6 E(): 2.2e-07%3B 38.9%25 identity in 144 aa overlap gene gene5760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5701 SCO5702 SCO5702 SC5H4.26c SC5H4.26c 6213362 6213925 - lipoprotein SC5H4.26c%2C possible lipoprotein%2C len: 187 aa%3B similar to TR:O05816 (EMBL:Z95207) Mycobacterium tuberculosis hypothetical 17.7 kD protein MTCY24A1.14c%2C 181 aa%3B fasta scores: opt: 152 z-score: 161.9 E(): 0.15%3B 32.6%25 identity in 178 aa overlap. Contains possible N-terminal region signal peptide sequence and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene5761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5702 SCO5703 SCO5703 SC5H4.27 SC5H4.27 6214338 6214871 + hypothetical protein in Streptococcus pneumoniae this gene was found to be essential%3B structure determination of the Streptococcus protein shows that it is similar to a number of other proteins gene gene5762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5703 SCO5704 SCO5704 nusA nusA 6214874 6215896 + transcription elongation factor NusA modifies transcription through interactions with RNA polymerase affecting elongation%2C readthrough%2C termination%2C and antitermination gene gene5763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5704 SCO5705 SCO5705 SC5H4.29 SC5H4.29 6215999 6216304 + hypothetical protein SC5H4.29%2C hypothetical protein%2C len: 101 aa%3B similar to SW:YLXR_BACSU (EMBL:Z18631) Bacillus subtilis hypothetical 10.4 kD protein in NusA-InfB intergenic region (ORF3) YlxR%2C 91 aa%3B fasta scores: opt: 130 z-score: 176.4 E(): 0.023%3B 29.7%25 identity in 91 aa overlap. Contains and match to Prosite entry gene gene5764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5705 SCO5706 SCO5706 infB infB 6216466 6219567 + translation initiation factor IF-2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex gene gene5765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5706 SCO5707 SCO5707 SC9F2.09c SC9F2.09c 6219719 6220012 + hypothetical protein SC9F2.09c%2C small conserved hypothetical protein%2C len: 97aa%3B similar to eg. TR:O33252 (EMBL:Z97559) hypothetical protein from Mycobacterium tuberculosis (97 aa) fasta scores%3B opt: 397%2C z-score: 552.5%2C E(): 1.8e-23%2C (64.9%25 identity in 97 aa overlap). gene gene5766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5707 SCO5708 SCO5708 rbfA rbfA 6220097 6220579 + ribosome-binding factor A associates with free 30S ribosomal subunits%3B essential for efficient processing of 16S rRNA%3B in Escherichia coli rbfA is induced by cold shock gene gene5767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5708 SCO5709 SCO5709 truB truB 6220576 6221481 + tRNA pseudouridine synthase B catalyzes isomerization of specific uridines in RNA to pseudouridine%3B responsible for residues in T loops of many tRNAs gene gene5768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5709 SCO5710 SCO5710 SC9F2.06c SC9F2.06c 6221737 6225837 + large Pro/Ala/Gly-rich protein SC9F2.06c%2C large Pro/Ala/Gly-rich protein of unknown function%2C len: 1366 aa gene gene5769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5710 SCO5711 SCO5711 ribC ribC 6225981 6226937 + bifunctional riboflavin kinase/FMN adenylyltransferase catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN%3B in Bacillus the ribC gene has both flavokinase and FAD synthetase activities gene gene5770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5711 SCO5712 SCO5712 SC9F2.04 SC9F2.04 6227052 6228131 - ABC transporter ATP-binding protein gene gene5771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5712 SCO5713 SCO5713 SC9F2.03 SC9F2.03 6228128 6229324 - ABC transporter ATP-binding protein gene gene5772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5713 SCO5714 SCO5714 SC9F2.02 SC9F2.02 6229321 6230274 - peptide transport permease SC9F2.02%2C possible peptide transport permease%2C len: 317aa%3B similar to many (confirmed and proposed) eg. SW:APPC_BACSU oligopeptide transport permease%2C AppC%2C from Bacillus subtilis (303 aa) fasta scores%3B opt: 638%2C z-score: 718.2%2C E(): 1.1e-32%2C (36.5%25 identity in 277 aa overlap). Contains probable membrane spanning hydrophobic regions. Also contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 42.30%2C E-value 1.1e-08. gene gene5773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5714 SCO5715 SCO5715 SC3C3.01c SC3C3.01c 6230271 6231227 - peptide transport system permease SC3C3.01c%2C probable peptide transport system integral membrane protein%2C partial CDS%2C len: >229 aa%3B similar to many e.g. DPPB_ECOLI dipeptide transport system permease (339 aa)%2C fasta scores%3B opt: 359 z-score: 654.6 E(): 3.3e-29%2C 35.3%25 identity in 238 aa overlap. Also similar to S. coelicolor SC2A11.12 (E(): 5.6e-12%2C 30.7%25 identity in 244 aa overlap)~SC9F2.01%2C partial CDS%2C possible peptide transport system permease%2C len:>140aa%3B constitutes the C-terminal half of a CDS whose N-terminal region (TR:O86635) lies on Streptomyces coelicolor cosmid SC3C3 (EMBL:AL031231). Similar to many dipeptide transport system permeases (confirmed and proposed) eg. SW:DPPB_ECOLI dipeptide transport system permease%2C DppB%2C from Escherichia coli (339 aa) fasta scores%3B opt: 391%2C z-score: 499.6%2C E(): 1.6e-20%2C (43.8%25 identity in 137 aa overlap). Contains probable membrane spanning hydrophobic regions. Also contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 24.30%2C E-value 0.0029. gene gene5774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5715 SCO5716 SCO5716 SC3C3.02c SC3C3.02c 6231310 6233175 - peptide transport system peptide binding protein SC3C3.02c%2C probable peptide transport system peptide binding protein%2C len: 621 aa%3B similar to e.g. DPPA_ECOLI periplasmic dipeptide transport protein precursor (535 aa)%2C fasta scores%3B opt: 195 z-score: 391.5 E(): 1.5e-14%2C 26.4%25 identity in 550 aa overlap. Contains N-terminals signal sequence%2C possible membrane anchor at C-terminus and Pfam match to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5%2C score 48.60%2C E-value 1.1e-11 gene gene5775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5716 SCO5717 SCO5717 SC3C3.03c SC3C3.03c 6233478 6236729 - hypothetical protein SC3C3.03c%2C unknown%2C len: 1083 aa%3B contains three large Pro- and Pro-Gln rich regions: the segment between the central and C-terminal Pro-Gln rich regions is similar to hypothetical proteins from Mycobacteria which also contain Pro-rich domains%3B e.g. M. tuberculosis TR:E1264127 (EMBL:AL022120) RV3876 (666 aa)%2C fasta scores%3B opt: 945 z-score: 387.0 E(): 2.7e-14%2C 31.2%25 identity in 693 aa overlap gene gene5776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5717 SCO5718 SCO5718 SC3C3.04 SC3C3.04 6237208 6238782 + hypothetical protein SC3C3.04%2C hypothetical protein%2C len: 524 aa%3B may contain N-terminal signal sequence with long leader gene gene5777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5718 SCO5719 SCO5719 SC3C3.05c SC3C3.05c 6238820 6239620 - hypothetical protein SC3C3.05c%2C unknown%2C len: 266 aa gene gene5778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5719 SCO5720 SCO5720 SC3C3.06c SC3C3.06c 6239617 6240885 - hypothetical protein SC3C3.06c%2C possible membrane protein%2C len: 422 aa%3B contains two possible transmembrane domains at N-terminus gene gene5779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5720 SCO5721 SCO5721 SC3C3.07 SC3C3.07 6241070 6242596 + hypothetical protein SC3C3.07%2C unknown%2C len: 508 aa%3B similar to three hypothetical proteins from M. tuberculosis e.g. TR:O06317 (EMBL:Z95390) MTCY13E12.03C (470 aa)%2C fasta scores%3B opt: 213 z-score: 330.7 E(): 3.7e-11%2C 28.0%25 identity in 508 aa overlap. Contains possible transmembrane domain at N-terminus gene gene5780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5721 SCO5722 SCO5722 SC3C3.08 SC3C3.08 6242668 6243909 + serine protease SC3C3.08%2C serine protease (hypothetical protein)%2C len: 413 aa%3B almost identical to TR:Q53863 (EMBL:U33176) serine protease (390 aa)%2C 98.4%25 identity in 387 aa overlap and similar to many e.g. ELYA_BACSP alkaline elastase yab precursor (378 aa)%2C fasta scores%3B opt: 466 z-score: 512.6 E(): 2.7e-21%2C 36.3%25 identity in 281 aa overlap. Also similar to downstream serine protease%2C SC3C3.17c (E(): 5.2e-07%2C 35.0%25 identity in 383 aa overlap). Contains PS00136%2C PS00137 and PS00138 Serine proteases%2C subtilase family%2C aspartic acid%2C histidine and serine active sites and Pfam match to entry PF00082 subtilase%2C Subtilase family of serine proteases%2C score 214.90%2C E-value 1.2e-60. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning region at C-terminal region gene gene5781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5722 SCO5723 SCO5723 bldB bldB 6243938 6244234 - regulator%2C BldB SC3C3.09c%2C possible regulator%2C BldB%2C len: 98 aa%3B identical to TR:Q53842 (EMBL:U28930) bldB (98 aa) and similar to S. coelicolor TR:Q53896 (EMBL:X60316) AbaA ORFD (75 aa)%2C fasta scores%3B opt: 150 z-score: 201.9 E(): 0.00055%2C 47.4%25 identity in 57 aa overlap gene gene5782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5723 SCO5724 SCO5724 SC3C3.10 SC3C3.10 6244538 6244912 + hypothetical protein SC3C3.10%2C unknown%2C len: 124 aa gene gene5783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5724 SCO5725 SCO5725 SC3C3.11 SC3C3.11 6244949 6245260 + hypothetical protein SC3C3.11%2C unknown%2C len: 103 aa gene gene5784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5725 SCO5726 SCO5726 SC3C3.12 SC3C3.12 6245381 6245860 + hypothetical protein SC3C3.12%2C unknown%2C len: 159 aa gene gene5785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5726 SCO5727 SCO5727 SC3C3.13 SC3C3.13 6245884 6246486 + hypothetical protein SC3C3.13%2C unknown%2C len: 200 aa gene gene5786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5727 SCO5728 SCO5728 SC3C3.14c SC3C3.14c 6246517 6247155 - hypothetical protein SC3C3.14c%2C probable hypothetical protein%2C len: 212 aa%3B contains N-terminal signal sequence gene gene5787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5728 SCO5729 SCO5729 SC3C3.15c SC3C3.15c 6247184 6249421 - hypothetical protein SC3C3.15c%2C hypothetical protein%2C len: 745 aa%3B similar to TR:Q9AFG1 (EMBL:AF349618) Streptomyces ansochromogenes AG2 protein%2C 760 aa%3B fasta scores: pt: 640 Z-score: 664.3 E(): 2.3e-29%3B 29.462%25 identity in 706 aa overlap gene gene5788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5729 SCO5730 SCO5730 SC3C3.16c SC3C3.16c 6249423 6249845 - hypothetical protein SC3C3.16c%2C unknown%2C len: 140 aa gene gene5789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5730 SCO5731 SCO5731 SC3C3.17c SC3C3.17c 6249911 6251263 - serine protease SC3C3.17c%2C possible serine protease%2C len: 450 aa%3B similar in part to many e.g. SUBT_BACSU subtilisin E precursor (381 aa)%2C fasta scores%3B opt: 321 z-score: 359.3 E(): 9.4e-13%2C 32.3%25 identity in 294 aa overlap. Also similar to downstream serine protease%2C SC3C3.08 (E(): 7.1e-07%2C 35.0%25 identity in 383 aa overlap). Contains N-terminal signal sequence%2C possible transmembrane domain at C-terminus and Pfam match to entry PF00082 subtilase%2C Subtilase family of serine proteases%2C score 151.00%2C E-value 2.1e-41 gene gene5790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5731 SCO5732 SCO5732 SC3C3.18c SC3C3.18c 6251294 6252847 - hypothetical protein SC3C3.18c%2C unknown%2C len: 517 aa%3B C-terminus is Gly-Pro-rich%2C and is predicted to be non-coding by FramePlot gene gene5791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5732 SCO5733 SCO5733 SC3C3.19c SC3C3.19c 6252847 6253335 - hypothetical protein SC3C3.19c%2C unknown%2C len: 162 aa gene gene5792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5733 SCO5734 SCO5734 SC3C3.20c SC3C3.20c 6253407 6257372 - ATP/GTP binding protein membrane protein SC3C3.20c%2C unknown ATP/GTP binding protein ( membrane protein)%2C len: 1321 aa%3B similar to several in M. tuberculosis and M. leprae e.g. M. tuberculosis TR:O06264 (EMBL:Z95389) MTCY77.19c%2C Rv3447c (1236 aa)%2C fasta scores%3B opt: 1186 z-score: 3117.9 E(): 0%2C 42.9%25 identity in 1312 aa overlap. Contains 3x%2C PS00017 ATP /GTP-binding site motif A (P-loop)%2C and a possible transmembrane domain near the C-terminus gene gene5793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5734 SCO5735 SCO5735 SC3C3.21 SC3C3.21 6257530 6259005 + hypothetical protein SC3C3.21%2C probable integral membrane protein%2C len: 491 aa%3B similar to hypothetical membrane protein from M. tuberculosis TR:O06265 (EMBL:Z95389) MTCY77.20 Rv3448 (467 aa)%2C fasta scores%3B opt: 192 z-score: 322.0 E(): 1.1e-10%2C 26.9%25 identity in 495 aa overlap gene gene5794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5735 SCO5736 SCO5736 rpsO rpsO 6259203 6259490 + 30S ribosomal protein S15 primary rRNA binding protein%3B helps nucleate assembly of 30S%3B binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA%3B autoregulates translation through interactions with the mRNA leader sequence gene gene5795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5736 SCO5737 SCO5737 gpsI gpsI 6259773 6261992 + polynucleotide phosphorylase/polyadenylase SC3C3.23%2C gpsI%2C guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase%2C partial CDS%2C len: >716 aa%3B almost identical to Streptomyces antibioticus GpsI TR:Q53597 (EMBL:U19858) guanosine pentaphosphate synthetase (740 aa)%2C 93.6%25 identity in 715 aa overlap. Contains Pfam match to entry PF00013 KH-domain%2C KH domain family of RNA binding proteins%2C score 27.40%2C E-value 0.00033 and Pfam match to entry PF00575 S1%2C S1 RNA binding LACR_STAAU motif%2C score 28.80%2C E-value 0.00013~SC9A10.01%2C gpsI%2C guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase%2C partial CDS%2C len: >57 aa%3B almost identical to Streptomyces antibioticus GpsI TR:Q53597 (EMBL:U19858) guanosine pentaphosphate synthetase (740 aa)%2C 87.9%25 identity in 58 aa overlap. Overlaps and extends SC3C3.23. gene gene5796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5737 SCO5738 SCO5738 SC9A10.02 SC9A10.02 6261989 6263368 + protease SC9A10.02%2C probable protease%2C len: 459 aa%3B similar to members of the insulinase family e.g. YMXG_BACSU hypothetical processing protease (409 aa)%2C fasta scores%3B opt: 648 z-score: 1449.2 E(): 0%2C 39.7%25 identity in 413 aa overlap and MPP2_YEAST mitochondrial processing peptidase beta subunit (462 aa)%2C fasta scores%3B opt: 583 z-score: 864.6 E(): 0%2C 29.7%25 identity in 448 aa overlap. Alternative start possible at aa 36. Contains PS00143 Insulinase family%2C zinc-binding region signature and Pfam match to entry PF00675 Insulinase%2C Insulinase (proteinase M16)%2C score 171.30%2C E-value 1.6e-47 gene gene5797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5738 SCO5739 SCO5739 dapB dapB 6263394 6264146 + 4-hydroxy-tetrahydrodipicolinate reductase catalyzes the reduction of 2%2C3-dihydrodipicolinate to 2%2C3%2C4%2C5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis gene gene5798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5739 SCO5740 SCO5740 SC9A10.04 SC9A10.04 6264160 6264615 + hypothetical protein SC9A10.04%2C possible membrane protein%2C len: 151 aa%3B similar to hypothetical proteins from Mycobacterium bovis and tuberculosis that follow dapB%2C e.g. YDAB_MYCBO hypothetical 19.3 kd protein in dapb 3'region (177 aa)%2C fasta scores%3B opt: 377 z-score: 696.1 E(): 1.7e-31%2C 47.1%25 identity in 136 aa overlap gene gene5799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5740 SCO5741 SCO5741 SC9A10.05c SC9A10.05c 6264691 6265245 - hypothetical protein SC9A10.05c%2C probable membrane protein%2C len: 184 aa gene gene5800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5741 SCO5742 SCO5742 SC9A10.06c SC9A10.06c 6265362 6265601 - hypothetical protein SC9A10.06c%2C membrane protein%2C len: 79 aa. Contains possible hydrophobic membrane spanning region gene gene5801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5742 SCO5743 SCO5743 thyX thyX 6265793 6266533 + FAD-dependent thymidylate synthase flavin dependent thymidylate synthase%3B ThyX%3B thymidylate synthase complementing protein%3B catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate%3B the enzyme from Mycobacterium tuberculosis forms homotetramers%3B uses FAD as a cofactor gene gene5802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5743 SCO5744 SCO5744 dapA dapA 6266753 6267652 + 4-hydroxy-tetrahydrodipicolinate synthase catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis gene gene5803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5744 SCO5745 SCO5745 SC9A10.09 SC9A10.09 6267805 6269490 + hypothetical protein SC9A10.09%2C unknown%2C len: 561 aa%3B similar to many members of the UPF0036 family e.g. YOR4_CORGL (645 aa)%2C fasta scores%3B opt: 1873 z-score: 1500.1 E(): 0%2C 55.6%25 identity in 493 aa overlap. Contains Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily%2C score 132.40%2C E-value 8.3e-36 gene gene5804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5745 SCO5746 SCO5746 SC7C7.01 SC7C7.01 6275223 6275900 + hypothetical protein SC7C7.01%2C unknown%2C len: 225 aa%3B some similarity to hydrophobic region from B. subtilis DEGT_BACST pleiotropic regulatory protein (372 aa)%2C fasta scores%3B opt: 289 z-score: 450.7 E(): 7.2e-18%2C 51.7%25 identity in 89 aa overlap. Also similar to e.g. TR:P72452 (EMBL:Y00459) aminotransferase from Streptomyces griseus(378 aa)%2C fasta scores%3B opt: 250 z-score: 429.3 E(): 1.1e-16%2C 29.4%25 identity in 309 aa overlap gene gene5808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5746 SCO5747 SCO5747 SC7C7.02c SC7C7.02c 6276106 6278856 - regulatory protein SC7C7.02c%2C possible regulatory protein%2C len: 916 aa%3B N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa)%2C fasta scores%3B opt: 248 z-score: 257.6 E(): 4.1e-07%2C 34.2%25 identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa)%2C fasta scores%3B opt: 232 z-score: 196.5 E(): 0.001%2C 26.3%25 identity in 240 aa overlap gene gene5810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5747 SCO5748 SCO5748 SC7C7.03 SC7C7.03 6279265 6284754 + sensory histidine kinase SC7C7.03%2C probable sensory histidine kinase%2C len: 1829 aa%3B N-terminus has 11 92aa repeats. Highly similar to osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus histidine kinase (1298 aa)%2C fasta scores%3B opt: 2011 z-score: 1764.6 E(): 0%2C 38.3%25 identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat)%2C fasta scores%3B opt: 378 z-score: 755.8%2C E(): 0%2C 28.9%25 identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphorylated receiver domain of two-component regulators e.g. SW:YEDW_ECOLI (239 aa)%2C blast scores%3B Expect %3D 3.1e-12%2C 32%25 identity in 115 aa overlap%2C and also to the downstream regulator SC7C7.04%3B 37.6%25 identity in 109 aa overlap. Contains probable coiled-coil from 1285 to 1364 and Pfam matches to entry signal PF00512%2C Signal C termial domain%2C score 230.38 and to entry response_reg PF00072%2C Response regulator receiver domain%2C score 146 gene gene5811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5748 SCO5749 SCO5749 SC7C7.04 SC7C7.04 6285256 6285930 + two-component regulator SC7C7.04%2C probable two-component regulator%2C len: 224 aa%3B similar to many e.g. PHOB_ECOLI phosphate regulon transcriptional regulator (229 aa)%2C fasta scores%3B opt: 200 z-score: 349.0 E(): 3.3e-12%2C 28.2%25 identity in 216 aa overlap. Contains probable coiled-coil from 153 to 195 and Pfam match to entry response_reg PF00072%2C Response regulator receiver domain%2C score 125.68 gene gene5812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5749 SCO5750 SCO5750 SC7C7.05 SC7C7.05 6286097 6288886 + ftsK-like protein SC7C7.05%2C ftsK homolog%2C integral membrane protein%2C len: 929%3B similar to members of the ftsK/spoIIIE family invoilved in cell division%2C e.g. ftsK/spoIIIE SP3E_BACSU stage iii sporulation protein E (787 aa)%2C fasta scores%3B opt: 1525 z-score: 1355.4 E(): 0%2C 45.1%25 identity in 552 aa overlapand FTSK_ECOLI cell division protein ftsK (1329 aa)%2C fasta scores%3B opt: 717 z-score: 1180.9 E(): 0%2C 37.1%25 identity in 701 aa overlap. Contains 7 degenerate repeats of AKKA(A/P) near N-terminus and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible hydrophobic membrane spanning regions gene gene5813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5750 SCO5751 SCO5751 SC7C7.06 SC7C7.06 6289190 6290053 + hypothetical protein SC7C7.06%2C membrane protein%2C len: 287 aa. Contains possible hydrophobic membrane spanning region gene gene5814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5751 SCO5752 SCO5752 SC7C7.07 SC7C7.07 6290145 6291626 + hypothetical protein SC7C7.07%2C unknown%2C len: 493 aa%3B similar to many members of the UPF0004 family e.g. YLIG_ECOLI (441 aa)%2C fasta scores%3B opt: 642 z-score: 947.7 E(): 0%2C 31.8%25 identity in 487 aa overlap. Contains PS01278 Uncharacterized protein family UPF0004 signature. Also similar to S. coelicolor SC4H2.08%2C fasta scores%3B E(): 9.1e-23%2C 30.3%25 identity in 445 aa overlap gene gene5815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5752 SCO5753 SCO5753 pgsA pgsA 6291623 6292414 + phosphatidylglycerophosphate synthase SC7C7.08%2C pgsA%2C probable phosphatidylglycerophosphate synthase%2C len: 263 aa%3B integral membrane protein similar to many e.g. PGSA_BACSU CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (193 aa)%2C fasta scores%3B opt: 304 z-score: 312.1 E(): 3.8e-10%2C 38.0%25 identity in 187 aa overlap. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. FramePlot suggests start site at V40%2C similarities start downstream of this. Upstream start site chosen by HMM%2C corroborated by RBS. Contains possible hydrophobic membrane spanning regions gene gene5816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5753 SCO5754 SCO5754 SC7C7.09 SC7C7.09 6292411 6292956 + hypothetical protein SC7C7.09%2C unknown%2C len: 181 aa%3B similar to competence damage induced proteins of B. subtilis and Streptococcus pneumoniae e.g. CINA_STRPN competence-damage protein (418 aa)%2C fasta scores%3B opt: 304 z-score: 431.6 E(): 8.4e-17%2C 35.8%25 identity in 165 aa overlap. Contains probable coiled-coil from 133 to 175 gene gene5817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5754 SCO5755 SCO5755 SC7C7.10 SC7C7.10 6293066 6293446 + hypothetical protein SC7C7.10%2C unknown%2C len: 126 aa%3B highly similar to M. tuberculosis TR:O33287 (EMBL:AL008967) possible transcriptional regulator MTV002.10C (Rv2745c) (112 aa)%2C fasta scores%3B opt: 300 z-score: 454.0 E(): 4.7e-18%2C 60.5%25 identity in 86 aa overlap gene gene5818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5755 SCO5756 SCO5756 SC7C7.11 SC7C7.11 6293651 6294121 + hypothetical protein SC7C7.11%2C unknown%2C len: 156 aa%3B similar to members of the Dps family e.g. FTPA_HAEDU fine tangled pili major subunit (24 KD surface protein) (189 aa)%2C fasta scores%3B opt: 278 z-score: 370.3 E(): 2.2e-13%2C 34.4%25 identity in 151 aa overlap PS_ECOLI DNA protection during starvation protein (166 aa) and%2C fasta scores%3B opt: 220 z-score: 261.2 E(): 2.6e-07%2C 26.8%25 identity in 153 aa overlap. Contains PS00818 Dps protein family signature 1 gene gene5819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5756 SCO5757 SCO5757 SC7C7.12 SC7C7.12 6294128 6294394 + hypothetical protein SC7C7.12%2C questionable ORF%2C len: 88 aa gene gene5820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5757 SCO5758 SCO5758 SC7C7.13 SC7C7.13 6294450 6294824 + transcriptional regulator SC7C7.13%2C possible transcriptional regulator%2C len: 124 aa%3B similar to several transcriptional regulators fomr M. tuberculosis e.g. TR:O53478 (EMBL:AL021899) regulator MTV018.21 (Rv2034) (107 aa)%2C fasta scores%3B opt: 178 z-score: 327.3 E(): 5.4e-11%2C 40.7%25 identity in 81 aa overlap. Contains probable helix-turn-helix motif at aa 34-55 (Score 999%2C +2.59 SD) gene gene5821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5758 SCO5759 SCO5759 SC7C7.14 SC7C7.14 6294821 6295306 + hypothetical protein SC7C7.14%2C unknown%2C len: 161 aa gene gene5822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5759 SCO5760 SCO5760 SC7C7.15c SC7C7.15c 6295344 6296174 - DNA glycosylase SC7C7.15c%2C probable DNA glycosylase involved in DNA repair%2C len: 276 aa%3B similar to e.g. END8_ECOLI endonuclease VIII (EC 3.2.-.-) (263 aa)%2C fasta scores%3B opt: 384 z-score: 449.2 E(): 8.7e-18%2C 34.5%25 identity in 278 aa overlap gene gene5823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5760 SCO5761 SCO5761 SC7C7.16c SC7C7.16c 6296193 6301265 - ATP-dependent DNA helicase SC7C7.16c%2C probable ATP dependent DNA helicase%2C len: 1690 aa%3B highly similar to e.g. LHR_ECOLI probable atp-dependent helicase lhr (EC 3.6.1.-) (1538 aa)%2C fasta scores%3B opt: 2361 z-score: 3018.1 E(): 0%2C 48.6%25 identity in 1435 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam matches to entry DEAD PF00270%2C DEAD and DEAH box helicases%2C score 30.04 and to entry helicase_C PF00271%2C Helicases conserved C-terminal domain%2C score 42.17 gene gene5824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5761 SCO5762 SCO5762 SC4H8.01 SC4H8.01 6301456 6302322 + AraC family transcription regulator SC4H8.01%2C unknown%2C partial CDS%2C len >29 aa~SC7C7.17%2C possible araC family transcriptional regulatory protein%2C len: 288 aa%3B some similarity to members of the araC family e.g. ADA_SALTY ADA regulatory protein (352 aa)%2C fasta scores%3B opt: 161 z-score: 197.6 E(): 0.0009%2C 31.0%25 identity in 129 aa overlap. Overlaps and extends CDS from neighboring cosmid SC4H8.01. Contains probable helix-turn-helix motif at aa 189-210 (Score 1161%2C +3.14 SD) and Pfam match to entry HTH_2 PF00165%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C score 74.61 gene gene5825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5762 SCO5763 SCO5763 SC4H8.02 SC4H8.02 6302319 6303089 + hypothetical protein SC4H8.02%2C possible membrane protein%2C len: 256 aa. Contains possible hydrophobic membrane spanning region gene gene5826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5763 SCO5764 SCO5764 SC4H8.03 SC4H8.03 6303086 6303394 + hypothetical protein SC4H8.03%2C membrane protein%2C len: 102 aa. Contains possible hydrophobic membrane spanning regions gene gene5827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5764 SCO5765 SCO5765 SC4H8.04c SC4H8.04c 6303404 6304429 - hypothetical protein SC4H8.04c%2C unknown%2C len: 341 aa%3B first start site used gene gene5828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5765 SCO5766 SCO5766 SC4H8.05 SC4H8.05 6304454 6304648 + hypothetical protein SC4H8.05%2C unknown%2C len: 64 aa%3B similar to M. tuberculosis hypothetical protein TR:E1173868 (MTV002.03c) (68 aa)%2C fasta scores%3B opt: 193 z-score: 307.9 E(): 5.8e-10%2C 40.6%25 identity in 64 aa overlap. Note that this protein is also upstream of RecA gene gene5829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5766 SCO5767 SCO5767 SC4H8.06 SC4H8.06 6304820 6306028 + hypothetical protein SC4H8.06%2C unknown%2C probable integral membrane protein%2C len: 402 aa%3B weakly similar to several hypotheical proteins from B. subtilis and Methanococcus e.g. TR:E1184257 (EMBL:Z99120) from B. subtilis (369 aa)%2C fasta scores%3B opt: 375 z-score: 321.7 E(): 1e-10%2C 24.1%25 identity in 348 aa overlap. C-terminal region highly similar to TR:Q54391 (EMBL:X76076) Streptomyces lividans RecA gene (fragment) 75 aa%3B fasta scores: opt: 490 Z-score: 548.1 E(): 6.7e-23%3B 96.000%25 identity in 75 aa overlap. Start site chosen by similarity. Contains possible hydrophobic membrane spanning regions gene gene5830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5767 SCO5768 SCO5768 SC4H8.07c SC4H8.07c 6306165 6306365 - hypothetical protein SC4H8.07c%2C unknown%2C len: 66 aa%3B similar to M. tuberculosis hypothetical protein TR:O06782 (EMBL:Z95972) MTCI376.19 (51 aa)%2C fasta scores%3B opt: 107 z-score: 185.7 E(): 0.0038%2C 38.6%25 identity in 44 aa overlap gene gene5831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5768 SCO5769 SCO5769 recA recA 6306654 6307778 + recombinase A catalyzes the hydrolysis of ATP in the presence of single-stranded DNA%2C the ATP-dependent uptake of single-stranded DNA by duplex DNA%2C and the ATP-dependent hybridization of homologous single-stranded DNAs gene gene5832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5769 SCO5770 SCO5770 recX recX 6307998 6308564 + recombination regulator RecX binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities gene gene5833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5770 SCO5771 SCO5771 SC4H8.10c SC4H8.10c 6308921 6309319 - hypothetical protein SC4H8.10c%2C hypothetical protein%2C len: 132 aa%3B similar to TR:AAK45350 (EMBL:AE006990) Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1096%2C 131 aa%3B fasta scores: opt: 429 Z-score: 543.2 E(): 1.3e-22%3B 57.143%25 identity in 119 aa overlap gene gene5834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5771 SCO5772 SCO5772 SC4H8.11c SC4H8.11c 6309316 6309864 - hypothetical protein SC4H8.11c%2C unknown%2C len: 182 aa gene gene5835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5772 SCO5773 SCO5773 SC4H8.12c SC4H8.12c 6310159 6311784 - monooxygenase SC4H8.12c%2C possible monooxygenase%2C len: 541 aa%3B weakly similar to many eg. TR:Q54171 (EMBL:X87093) oxygenase urdE from Streptomyces fradiae (495 aa)%2C fasta scores%3B opt: 333 z-score: 428.9 E(): 1.1e-16%2C 30.4%25 identity in 539 aa overlap gene gene5836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5773 SCO5774 SCO5774 gluD gluD 6311961 6312860 - glutamate permease SC4H8.13c%2C gluD%2C probable glutamate permease%2C len: 299%3B similar to many members of the HisMQ subfamily of the binding-protein dependent transporters eg. GLUD_CORGL P48245 glutamate transport system permease from Corynebacterium glutamicum (273 aa)%2C fasta scores%3B opt: 673 z-score: 843.4 E(): 0%2C 47.0%25 identity in 251 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature gene gene5837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5774 SCO5775 SCO5775 gluC gluC 6312857 6313525 - glutamate permease SC4H8.14c%2C gluC%2C probable glutamate permease%2C len: 222%3B similar to many members of the HisMQ subfamily of the binding-protein dependent transporters eg. GLUC_CORGL P48244 glutamate transport system permease from Corynebacterium glutamicum (225 aa)%2C fasta scores%3B opt: 730 z-score: 1209.4 E(): 0%2C 58.8%25 identity in 199 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature gene gene5838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5775 SCO5776 SCO5776 gluB gluB 6313610 6314446 - glutamate binding protein SC4H8.15c%2C gluB%2C probable glutamate binding protein%2C len: 278 aa%3B similar to many members of the periplasmic solute-binding family 3 eg. GLUB_CORGL P48242 glutamate-binding protein precursor from Corynebacterium glutamicum (295 aa)%2C fasta scores%3B opt: 733 z-score: 768.3 E(): 0%2C 46.9%25 identity in 277 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site%3B also contains PS01039 Bacterial extracellular solute-binding proteins%2C family 3 signature gene gene5839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5776 SCO5777 SCO5777 gluA gluA 6314572 6315348 - glutamate uptake system ATP-binding protein SC4H8.16c%2C gluA%2C probable glutamate uptake system ATP-binding protein%2C len: 258 aa%3B highly similar to many amino-acid uptake ATP-binding proteins eg. GLUA_CORGL P48243 glutamate transport atp-binding protein from Corynebacterium gluamicum (242 aa)%2C fasta scores%3B opt: 1152 z-score: 1564.5 E(): 0%2C 71.5%25 identity in 242 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene5840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5777 SCO5778 SCO5778 SC4H8.17 SC4H8.17 6315651 6316337 + two-component system regulator SC4H8.17%2C two-component system transcriptional regulator%2C len: 228 aa%3B similar to many eg. VANR_ENTFA Q47744 regulatory protein VanR from enterococcuus faecalis (220 aa)%2C fasta scores%3B opt: 469 z-score: 742.2 E(): 0%2C 37.1%25 identity in 224 aa overlap gene gene5841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5778 SCO5779 SCO5779 SC4H8.18 SC4H8.18 6316347 6317792 + two-component system sensor SC4H8.18%2C two-component system sensor/histidine kinase%2C partial CDS%2C len: >481 aa%3B similar to many e.g. COPS_PSESM Q02541 sensor protein CopS from Pseudomonas syringae (487 aa)%2C fasta scores%3B opt: 324 z-score: 387.1 E(): 2.3e-14%2C 24.8%25 identity in 456 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5779 SCO5780 SCO5780 SC4H2.01c SC4H2.01c 6317771 6318766 - hypothetical protein SC4H2.01c%2C probable hypothetical protein%2C len: 331 aa%3B some similarity to a hypothetical protein from Brucella abortus BCSP_BRUAB P12920 31 kd immunogenic protein precursor (329 aa)%2C fasta scores%3B opt: 399 z-score: 357.4 E(): 1.1e-12%2C 32.7%25 identity in 336 aa overlap. Contains probable N-terminal signal sequence gene gene5843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5780 SCO5781 SCO5781 SC4H2.02 SC4H2.02 6318816 6319355 + hypothetical protein SC4H2.02%2C hypothetical protein%2C len: 179 aa%3B Proline-rich in N-terminus. Contains possible N-terminal region signal peptide sequence gene gene5844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5781 SCO5782 SCO5782 SC4H2.03c SC4H2.03c 6319451 6320686 - transmembrane transport protein SC4H2.03c%2C possible transmembrane transport protein%2C len: 411 aa%3B similar to several hypothetical proteins e.g. M. tuberculosis TR:O05881 (EMBL:Z95121) MTCY20B11.11C (385 aa)%2C fasta scores opt: 1226 z-score: 1612.0 E(): 0%2C 53.5%25 identity in 372 aa overlap%2C and to members of the KEFB/KEFC potassium transporters family e.g. KEFB_ECOLI P45522 glutathione-regulated potassium-efflux protein (601 aa)%2C fastascores%3B opt: 327 z-score: 292.9 E(): 4.3e-09%2C 25.3%25 identity in 396 aa overlap gene gene5845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5782 SCO5783 SCO5783 SC4H2.04c SC4H2.04c 6320691 6321176 - hypothetical protein SC4H2.04c%2C hypothetical protein%2C len: 161 aa%3B similar to hypothetical proteins from several organisms e.g. M. tuberculosis TR:O05882 (EMBL:Z95121) MTCY20B11.12C (160 aa)%2C fasta scores%3B opt: 315 z-score: 557.4 E(): 8e-24%2C 40.0%25 identity in 150 aa overlap (also upstream of a transport protein) gene gene5846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5783 SCO5784 SCO5784 SC4H2.05 SC4H2.05 6321291 6322367 + two-component sensor SC4H2.05%2C probable two-component sensor protein%2C len: 358 aa%3B similar to many e.g. DEGS_BACSU P13799 sensor protein DegS (ec 2.7.3.-)%2C Bacillus subtilis (385 aa)%2C fasta scores%3B opt: 317 z-score: 334.6 E(): 2e-11%2C 31.3%25 identity in 227 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5784 SCO5785 SCO5785 SC4H2.06 SC4H2.06 6322367 6323026 + two-component regulator SC4H2.06%2C probable two-component transcriptional regulator%2C len: 219 aa%3B similar to many e.g. DEGU_BACSU P13800 transcriptional regulatory protein DegU (229 aa)%2C fasta scores%3B opt: 343 z-score: 736.1 E(): 0%2C 37.1%25 identity in 224 aa overlap. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature%2C Pfam match to entry response_reg PF00072%2C Response regulator receiver domain%2C score 147.25 and Pfam match to entry GerE PF00196%2C Bacterial regulatory proteins%2C luxR family%2C score 99.11 gene gene5848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5785 SCO5786 SCO5786 SC4H2.07c SC4H2.07c 6323081 6324283 - hydrolase SC4H2.07c%2C possible hydrolase%2C len: 400 aa%3B similar in N-terminus to many e.g GUNA_STRLI P27035 endoglucanase CelA precursor (459 aa)%2C fasta scores%3B opt: 376 z-score: 257.5 E(): 4e-07%2C 37.7%25 identity in 175 aa overlap. Contains a very Thr- Pro-rich region at aa 143-170%2C a possible N-terminal signal sequence and an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. C-terminal region has no apparent similarities. Also contains a TTA leucine codon%3B a potential target for action of bldA gene gene5849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5786 SCO5787 SCO5787 SC4H2.08 SC4H2.08 6324453 6325970 + (dimethylallyl)adenosine tRNA methylthiotransferase catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) gene gene5850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5787 SCO5788 SCO5788 SC4H2.09 SC4H2.09 6326020 6326733 + hypothetical protein SC4H2.09%2C unknown%2C len: 237 aa%3B similar to a hypothetical protein from Mycobacterium tuberculosis and M. leprae%2C TTR:O33233 (EMBL:Z98209) MTCY154.08C (231 aa)%2C fasta scores%3B opt: 306 z-score: 320.4 E(): 1.3e-10%2C 33.2%25 identity in 241 aa overlap gene gene5851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5788 SCO5789 SCO5789 SC4H2.10c SC4H2.10c 6326868 6327161 - hypothetical protein SC4H2.10c%2C unknown%2C len: 97 aa gene gene5852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5789 SCO5790 SCO5790 SC4H2.11c SC4H2.11c 6327186 6327473 - hypothetical protein SC4H2.11c%2C unknown%2C len: 95 aa gene gene5853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5790 SCO5791 SCO5791 miaA miaA 6327656 6328594 + tRNA delta(2)-isopentenylpyrophosphate transferase IPP transferase%3B isopentenyltransferase%3B involved in tRNA modification%3B in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil%3B further tRNA modifications may occur%3B mutations in miaA result in defects in translation efficiency and fidelity gene gene5854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5791 SCO5792 SCO5792 SC4H2.13 SC4H2.13 6328696 6329199 + transmembrane protein SC4H2.13%2C probable transmembrane protein%2C len: 167 aa%3B contains three possible transmembrane domains in C-terminus gene gene5855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5792 SCO5793 SCO5793 dapF dapF 6329272 6330141 + diaminopimelate epimerase involved in lysine biosynthesis%3B DAP epimerase%3B produces DL-diaminopimelate from LL-diaminopimelate gene gene5856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5793 SCO5794 SCO5794 SC4H2.15 SC4H2.15 6330388 6332565 + kinase/phosphohydrolase SC4H2.15%2C possible kinase/phosphohydrolase%2C len: 725%3B similar to many RelA and SpoT genes e.g. RELA_STRCO P52560 GTP pyrophosphokinase (ec 2.7.6.5) (847 aa)%2C fasta scores%3B opt: 1049 z-score: 1312.4 E(): 0%2C 39.5%25 identity in 792 aa overlap and SPOT_ECOLI P17580 guanosine-3'%2C5'-bis(diphosphate) 3'-pyrophosphohydrolase (702 aa)%2C fasta scores%3B opt:1040 z-score: 867.0 E(): 0%2C 33.8%25 identity in 695 aa overlap gene gene5857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5794 SCO5795 SCO5795 SC4H2.16 SC4H2.16 6332816 6334354 + zinc metalloprotease membrane protein SC4H2.16%2C probable zinc metalloprotease ( membrane protein)%2C len: 512 aa%3B weakly similar to the N-terminus of many%2C longer%2C aminopeptidases%2C e.g. AMPN_LACLA Q48656 aminopeptidase n (ec 3.4.11.2) (848 aa)%2C fasta scores%3B opt: 304 z-score: 287.5 E(): 8.6e-09%2C 25.2%25 identity in 440 aa overlap. Contains match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature and Pfam match to entry zn-protease PF00099%2C Zinc-binding metalloprotease domain%2C score 28.22. Contains possible hydrophobic membrane spanning region gene gene5858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5795 SCO5796 SCO5796 SC4H2.17 SC4H2.17 6334502 6335995 + hypothetical protein SC4H2.17%2C unknown%2C len: 497 aa%3B similar to hypothetical proteins from many organisms e.g. HFLX_ECOLI P25519 GTP-binding protein HflX (426 aa)%2C fasta scores%3B opt: 904 z-score: 715.0 E(): 1.3e-32%2C 39.6%25 identity in 407 aa overlap.Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains probable coiled-coil from aa 235 to 271 gene gene5859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5796 SCO5797 SCO5797 SC4H2.18c SC4H2.18c 6336091 6337308 - hypothetical protein SC4H2.18c%2C probable hypothetical protein%2C len: 405 aa%3B Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Highly similar to upstream CDS SC4H2.19c (409 aa)%2C fasta scores%3B E(): 0%2C 61.8%25 identity in 406 aa overlap gene gene5860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5797 SCO5798 SCO5798 SC4H2.19c SC4H2.19c 6337406 6338635 - hypothetical protein SC4H2.19c%2C probable hypothetical protein%2C len: 409 aa%3B Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Highly similar to downstream CDS SC4H2.18c (405 aa)%2C fasta scores%3B E(): 0%2C 61.8%25 identity in 406 aa overlap gene gene5861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5798 SCO5799 SCO5799 SC4H2.20 SC4H2.20 6338949 6340547 + aminotransferase SC4H2.20%2C probable aminotransferase%2C len: 532%3B similar to many e.g. GABT_ECOLI P22256 4-aminobutyrate aminotransferase (426 aa)%2C fasta scores%3B opt: 355 z-score: 385.5 E(): 3e-14%2C 28.8%25 identity in 427 aa overlap. Contains two repetitive regions: GSGSGTGPGSGTGPGTGTGPGTGPGTGPG between aa 82-104%2C and VTVTDAVTVTDAVTDADADAD between aa 241-261%2C that are not present in other aminotransferases. Also contains 2x match to Pfam match to entry aminotran_3 PF00202%2C Aminotransferases class-III pyridoxal-phosphate%2C scores 72.94 and 175.90%2C and TTA leucine codon%3B a potential target for actionof bldA gene gene5862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5799 SCO5800 SCO5800 SC4H2.21 SC4H2.21 6340587 6342533 + hypothetical protein SC4H2.21%2C unknown%2C len: 648 aa%3B similar to proteins implicated in siderophore biosynthesis eg. SW:RHSC_RHIME (EMBL:AF110737) rhizobactin siderophore biosynthesis protein RhsC from Rhizobium meliloti (585 aa) fasta scores%3B opt: 1215%2C Z-score: 1075.6%2C E(): 3.6e-53%2C 40.000%25 identity (41.912%25 ungapped) in 570 aa overlap. Very weak similarity to TR:Q47316 (EMBL:X76100) E. coli plasmid pColV-K30 iucA gene (575 aa)%2C fasta scores%3B opt: 695 z-score: 458.0 E(): 2.6e-18%2C 30.1%25 identity in 555 aa overlap. Contains PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site gene gene5863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5800 SCO5801 SCO5801 SC4H2.22 SC4H2.22 6342563 6343258 + hypothetical protein SC4H2.22%2C unknown%2C len: 231 aa%3B some similarity to C-terminus of Saccharopolyspora erythraea malonyl CoA decarboxylase TR:Q54112 (EMBL:L05192) (417 aa)%2C fasta scores%3B opt: 434 z-score: 630.6 E(): 6.6e-28%2C 40.5%25 identity in 190 aa overlap and similar to the pSymA plasmid borne TR:AAK65919 (EMBL:AE007311) Rhizobium meliloti (Sinorhizobium meliloti) RhbD rhizobactin siderophore biosynthesis protein%2C 196 aa%3B fasta scores: opt: 387 Z-score: 454.4 E(): 1.1e-17%3B 35.106%25 identity in 188 aa overlap gene gene5864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5801 SCO5802 SCO5802 SC4H2.23 SC4H2.23 6343581 6345575 + ATP-dependent helicase SC4H2.23%2C probable ATP-dependent helicase%2C len: 664 aa%3B similar to e.g. DING_ECOLI P27296 probable ATP-dependent helicase dinG (716 aa)%2C fasta scores opt: 272 z-score: 409.8 E(): 1.3e-15%2C 26.5%25 identity in 686 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5802 SCO5803 SCO5803 lexA lexA 6345664 6346368 - LexA repressor Represses a number of genes involved in the response to DNA damage gene gene5866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5803 SCO5804 SCO5804 nrdR nrdR 6347027 6347575 + transcriptional regulator NrdR SC4H2.25%2C unknown%2C len: 182 aa%3B similar to hypothetical genes from a wide range of organisms e.g. YBAD_ECOLI P25538 hypothetical 17.2 kd protein in tsx-ribG (149 aa)%2C fasta scores%3B opt: 426 z-score: 367.0 E(): 3.2e-13%2C 43.0%25 identity in 149 aa overlap gene gene5867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5804 SCO5805 SCO5805 nrdJ nrdJ 6347744 6350647 + vitamin B12-dependent ribonucleotide reductase catalyzes the reduction of ribonucleotides to deoxyribonucleotides%3B the rate-limiting step in dNTP synthesis gene gene5868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5805 SCO5806 SCO5806 SC4H2.27c SC4H2.27c 6350725 6351333 - hypothetical protein SC4H2.27c%2C hypotehtical protein%2C len: 202 aa%3B contains PS00017 ATP/GTP-binding site motif A (P-loop). Start site uncertain. Similar to TR:CAC37539 (EMBL:AL590982) Streptomyces coelicolor conserved hypothetical protein SCIF3.20c%2C 190 aa%3B fasta scores: opt: 685 Z-score: 693.9 E(): 5.1e-31%3B 56.111%25 identityin 180 aa overlap gene gene5869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5806 SCO5807 SCO5807 SC4H2.28 SC4H2.28 6351356 6352033 + hypothetical protein SC4H2.28%2C unknown%2C len: 225 aa%3B start site uncertain gene gene5870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5807 SCO5808 SCO5808 SC4H2.29 SC4H2.29 6352147 6352806 + hypothetical protein SC4H2.29%2C unknown%2C len: 219 aa%3B highly similar to several eukaryotic hypothetical proteins e.g. Arabidopsis thaliana TR:O04035 (EMBL:AC000106) F7G19.18 (281 aa)%2C fasta scores%3B opt: 482 z-score: 1008.5 E(): 0%2C 47.0%25 identity in 217 aa overlap. Contains PS00175 Phosphoglycerate mutase family phosphohistidine signature and Pfam match to entry PGAM PF00300%2C Phosphoglycerate mutase family%2C score 20.30 gene gene5871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5808 SCO5809 SCO5809 SC4H2.30 SC4H2.30 6352819 6353724 + hydrolase SC4H2.30%2C possible hydrolase%2C len: 301 aa%3B some similarity to several e.g. DRAG_RHORU P14300 adp-ribosylglycohydrolase (294 aa)%2C fasta scores%3B opt: 92 z-score: 265.8 E(): 1.4e-07%2C 25.3%25 identity in 296 aa overlap gene gene5872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5809 SCO5810 SCO5810 SC4H2.31c SC4H2.31c 6354012 6355559 - transmembrane efflux protein SC4H2.31c%2C probable transmembrane efflux protein%2C len: 515 aa%3B similar to many diverse efflux proteins e.g. CMCT_NOCLA Q04733 cephamycin export protein cmct (486 aa)%2C fasta scores%3B opt: 1059 z-score: 1207.4 E(): 0%2C 40.2%25 identity in 433 aa overlap%2C and PUR8_STRLP P42670 puromycin resistance protein pur8 (503 aa)%2C fasta scores%3B opt: 1135 z-score: 1187.0 E(): 0%2C 39.8%25 identity in 492 aa overlap. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and Pfam match to entry sugar_tr PF00083%2C Sugar (and other) transporters%2C score 33.27 gene gene5873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5810 SCO5811 SCO5811 SC4H2.32 SC4H2.32 6355747 6356367 + transcriptional regulator SC5B8.01%2C probable transcriptional regulator%2C partial CDS%2C overlaps and extends SC4H2.32%2C len: > 140 aa~SC4H2.32%2C probable transcriptional regulator%2C partial CDS%2C len: >111 aa%3B similar to many e.g. TR:D1022772 (EMBL:D85417) HemR from Propionibacterium freudenreichii (243 aa)%2C fasta scores%3B opt: 262 z-score: 366.7 E(): 3.3e-13%2C 46.5%25 identity in 101 aa overlap. Contains Pfam match to entry tetR PF00440%2C Bacterial regulatory proteins%2C tetR family%2C score 29.06 gene gene5874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5811 SCO5812 SCO5812 rnhB rnhB 6356449 6357150 + ribonuclease HII RNH2%3B RNase HII%3B binds manganese%3B endonuclease which specifically degrades the RNA of RNA-DNA hybrids gene gene5875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5812 SCO5813 SCO5813 SC5B8.03 SC5B8.03 6357219 6357857 + hypothetical protein SC5B8.03%2C unknown%2C len: 212 aa%3B highly Proline rich in N-terminus gene gene5876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5813 SCO5814 SCO5814 SC5B8.04c SC5B8.04c 6358172 6358786 - hypothetical protein SC5B8.04c%2C unknown%2C len: 204 aa gene gene5877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5814 SCO5815 SCO5815 SCO5815 6359074 6361233 + ATP-dependent DNA helicase SC5B8.05%2C probable ATP-dependent DNA helicase%2C len:7 19 aa%3B similar in N-terminal half to many e.g. RECQ_ECOLIP1 5043 atp-dependent dna helicase recq (607 aa)%2C fasta score s%3B opt: 546 z-score: 615.9 E(): 4.1e-27%2C 35.9%25 identity in 362 aa overlap. Contains PS00690 DEAH-box subfamily ATP-dep endent helicases signature and Pfam match to entry helicase _C PF00271%2C Helicases conserved C-terminal domain%2C score 91 .14 gene gene5878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5815 SCO5816 SCO5816 SC5B8.06 SC5B8.06 6361399 6363003 + hypothetical protein SC5B8.06%2C unknown%2C len: 534 aa. Contains Probable coiled-coil from 234 to 270 gene gene5879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5816 SCO5817 SCO5817 SCO5817 6363009 6363893 + DNA hydrolase SC5B8.07%2C possible DNA hydrolase with mutT domain%2C l en: 294 aa%3B similar in part to many hypothetical proteins e .g Synechocystis sp. TR:P74291 (EMBL:D90913) (261 aa)%2C fasta scores%3B opt: 241 z-score: 358.0 E(): 9.6e-13%2C 34.7%25 ident ity in 251 aa overlap. Contains PS00893 mutT domain signatu re and Pfam match to entry mutT PF00293%2C Bacterial mutT pro tein%2C score 39.86 gene gene5880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5817 SCO5818 SCO5818 SCO5818 6363949 6366183 + ABC transporter SC5B8.08%2C probable ABC transporter%2C len: 744 aa%3B N-t erminus is similar to several ABC transporters e.g. NODI_RH IGA P50332 from Rhizobium galegae nodulation atp-binding pr otein (347 aa)%2C fasta scores%3B opt: 285 z-score: 225.2 E():2 .4e-05%2C 34.5%25 identity in 197 aa overlap%2C and contains PS00 017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry ABC_tran PF00005%2C ABC transporters%2C score 135.08. Th e C-terminus (approx aa 500-744) contains several probable transmembrane domains. In the centre is a repetitive region containing 10 copies of a degenerate 7 aa Proline-rich rep eat. gene gene5881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5818 SCO5819 SCO5819 SCO5819 6366349 6367236 + sporulation transcription factor%2C WhiH SC5B8.09%2C whiH%2C sporulation transcription factor%2C le n: 295%3B almost identical to whiH protein TR:E1198707 (EMBL: AJ003022) (295 aa)%2C 99.0%25 identity in 295 aa overlap. First of several possible start sites shown. Also similar to man y transcriptional regulators%2C e.g. DGOR_ECOLI P31460 galact onate operon transcriptional regulator (177 aa)%2C fasta scor es%3B opt: 240 z-score: 251.2 E(): 8.5e-07%2C 30.1%25 identity in 173 aa overlap. Contains Pfam match to entry gntR PF00392%2C Bacterial regulatory proteins%2C gntR family%2C score 56.85 gene gene5882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5819 SCO5820 SCO5820 hrdB hrdB 6367665 6369200 + RNA polymerase sigma factor sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released gene gene5883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5820 SCO5821 SCO5821 SCO5821 6369367 6370224 + serine protease SC5B8.11%2C probable serine protease%2C len: 285 aa%3B similar to many members of the trypsin family e.g. TRYP_SACERP 24664 from saccharopolyspora erythraea (streptomyces erythraeus) (227 aa)%2C fasta scores%3B opt: 523 z-score: 655.1 E(): 2.7e-29%2C 44.7%25 identity in 237 aa overlap. Contains PS00134 Serine proteases%2C trypsin family%2C histidine active site%2C PS00135 Serine proteases%2C trypsin family%2C serine active site and Pfam match to entry trypsin PF00089%2C Trypsin%2C score 228.48 gene gene5884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5821 SCO5822 SCO5822 SCO5822 6371006 6373129 + DNA topoisomerase IV subunit B decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling gene gene5885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5822 SCO5823 SCO5823 SCO5823 6373348 6373872 + hypothetical protein SC5B8.13%2C probable integral membrane protein%2C len: 1 74 aa%3B contains five possible transmembrane domains gene gene5886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5823 SCO5824 SCO5824 SC5B8.14 SC5B8.14 6373869 6375023 + two-component sensor SC5B8.14%2C probable two-component sensor%2C len: 384 aa%3B N-termius has six possible transmembrane domains%2C C-terminus is similar to histidine kinase domain of many two-component sensors e.g. NARQ_ECOLI P27896 nitrate/nitrite sensor (566 aa) fasta scores%3B opt: 220 z-score: 227.4 E(): 1.8e-0 5%2C 32.3%25 identity in 198 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5824 SCO5825 SCO5825 SC5B8.15 SC5B8.15 6375020 6375709 + two-component response regulator SC5B8.15%2C probable two-component transcriptional regulator%2C len: 229 aa%3B similar to many e.g. DEGU_BACSU P13800 transcriptional regulator (229 aa)%2C fasta scores%3B opt: 485 z-score: 582.9 E(): 2.8e-25%2C 37.1%25 identity in 221 aa overlap. Contains PS00622 Bacterial regulatory proteins%2C luxR f amily signature%2C Pfam match to entry response_reg PF00072%2C Response regulator receiver domain%2C score 142.77%2C Pfam match to entry GerE PF00196%2C Bacterial regulatory proteins%2C luxR family%2C score 80.81%2C and probable helix-turn-helix from aa 180-201 (Score 1092%2C +2.91 SD) gene gene5888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5825 SCO5826 SCO5826 SC5B8.16 SC5B8.16 6375779 6376357 + hypothetical protein SC5B8.16%2C membrane protein%2C len: 192 aa. Contains possible hydrophobic membrane spanning regions gene gene5889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5826 SCO5827 SCO5827 SCO5827 6376354 6377946 + transmembrane transport protein SC5B8.17%2C probable transmembrane transport protein%2C len: 530 aa%3B member of the sodium:solute symporter family%2C similar to many e.g. YJCG_ECOLI P32705 hypothetical protein %2C (549 aa)%2C fasta scores%3B opt: 935 z-score: 1534.8 E(): 0%2C 43.6%25 identity in 530 aa overlap. Contains Pfam match to en try SSF PF00474%2C Sodium:solute symporter family%2C score 338. 37 gene gene5890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5827 SCO5828 SCO5828 SC5B8.18c SC5B8.18c 6377983 6378663 - two-component transcriptional regulator SC5B8.18c%2C probable two-component transcriptional regulator%2C len: 226 aa%3B similar to many e.g. CITB_KLEPN P5268 8 transcriptional regulator from klebsiella pneumoniae (23 4 aa)%2C fasta scores%3B opt: 319 z-score: 394.9 E(): 8.3e-15%2C 30.8%25 identity in 224 aa overlap. Contains Pfam match to entry response_reg PF00072%2C Response regulator receiver domain%2C score 117.43 and probable helix-turn-helix from aa 176- 197 (Score 2073%2C +6.25 SD) gene gene5891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5828 SCO5829 SCO5829 SC5B8.19c SC5B8.19c 6378660 6380360 - two-component sensor SC5B8.19c%2C probable two-component sensor%2C len: 566 aa%3B similar to many e.g. CITA_KLEPN P52687 klebsiella pneumoniae sensor kinase (547 aa)%2C fasta scores%3B opt: 604 z-score: 460.1 E(): 2e-18%2C 27.1%25 identity in 554 aa overlap. Contains Pfam match to entry signal PF00512%2C Signal C terminal domain%2C score 98.50. Contains possible hydrophobic membrane spanning regions gene gene5892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5829 SCO5830 SCO5830 SCO5830 6380416 6381357 - hypothetical protein SC5B8.20c%2C unknown%2C len: 313 aa%3B very weak similarit y to a hypothetical protein from Synechocystis TR:P72597 (E MBL:D90899) (321 aa)%2C fasta scores%3B opt: 232 z-score: 291.9 E(): 4.6e-09%2C 23.1%25 identity in 268 aa overlap gene gene5893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5830 SCO5831 SCO5831 SCO5831 6381412 6382677 - citrate synthase-like protein SC5B8.21c%2C citrate synthase-like protein%2C len: 421 a a%3B similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa)%2C fasta scores%3B opt: 387 z-score: 460.4 E(): 1.9e-1 8%2C 30.2%25 identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285%2C Citrate synthase%2C score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757%2C +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11%2C 32.8%25 identity in 351 aa overlap. gene gene5894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5831 SCO5832 SCO5832 SCO5832 6382802 6383974 + citrate synthase SC5B8.22%2C citrate synthase%2C len: 390 aa %3B similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa )%2C fasta scores%3B opt: 729 z-score: 877.4 E(): 0%2C 35.5%25 iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285%2C Citr ate synthase%2C score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14%2C 32.4%25 identity in 352 aa overlap gene gene5895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5832 SCO5833 SCO5833 SCO5833 6384115 6384351 - hypothetical protein SC5B8.23c%2C unknown%2C len: 78 aa gene gene5896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5833 SCO5834 SCO5834 SC9B10.01c SC9B10.01c 6384501 6385247 - hypothetical protein SC9B10.01c%2C membrane protein%2C len: 248 aa. Contains possible hydrophobic membrane spanning region gene gene5897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5834 SCO5835 SCO5835 SC9B10.02 SC9B10.02 6385339 6386427 + ATP/GTP-binding protein SC9B10.02%2C possible ATP/GTP binding protein%2C len: 362 aa%3B similar in N-terminus to other ATP/GTP binding proteins eg. COBW_PSEDE P29937 cobw protein from pseudomonas denitrificans (353 aa)%2C fasta scores%3B opt: 302 z-score: 390.2 E(): 1.4e-14%2C 30.1%25 identity in 366 aa overlap and to TR:Q9RRS7 (EMBL:AE002071) Deinococcus radiodurans CobW protein%2C %2C DR2408%2C 320 aa%3B fasta scores: opt: 434 Z-score: 475.8 E(): 7.2e-19%3B 34.412%25 identity in 340 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5835 SCO5836 SCO5836 SC9B10.03c SC9B10.03c 6386424 6388880 - DNA topoisomerase IV subunit A decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling gene gene5899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5836 SCO5837 SCO5837 SC9B10.04 SC9B10.04 6389216 6390568 + zinc protease SC9B10.04%2C probable zinc protease%2C len: 450 aa%3B weakly similar to many of prokaryotic and eukaryotic origin eg. Y4WA_RHISN P55679 hypothetical zinc protease y4wa from Rhizobium sp. (512 aa)%2C fasta scores%3B opt: 617 z-score: 325.0 E(): 6.1e-11%2C 30.8%25 identity in 426 aa overlap%3B and MPP2_YEAST P10507 mitochondrial processing peptidase beta subunit (462 aa)%2C fasta scores%3B opt: 355 z-score: 321.6 E(): 9.4e-11%2C 25.3%25 identity in 415 aa overlap. The zinc-binding and active site residues are conserved gene gene5900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5837 SCO5838 SCO5838 SC9B10.05 SC9B10.05 6390565 6391953 + protease SC9B10.05%2C possible protease%2C len: 462%3B weakly similar to several hypothetical proteases eg. TR:P73669 (EMBL:D90908) processing protease from Synechocystis sp. (435 aa)%2C fasta scores%3B opt: 363 z-score: 293.0 E(): 3.7e-09%2C 26.0%25 identity in 439 aa overlap gene gene5901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5838 SCO5839 SCO5839 SC9B10.06 SC9B10.06 6392322 6393074 + hypothetical protein SC9B10.06%2C membrane protein%2C len: 250 aa%3B similar in part to several hypothetical proteins and to TR:P74894 (EMBL:U50357) bacteriocin-like inhibitory substance ZooA from Streptococcus zooepidemicus (285 aa)%2C fasta scores%3B opt: 278 z-score: 314.8 E(): 2.3e-10%2C 37.4%25 identity in 139 aa overlap%2C Contains probable coiled-coil region from aa 72 to 118. Contains possible hydrophobic membrane spanning regions gene gene5902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5839 SCO5840 SCO5840 SC9B10.07 SC9B10.07 6393195 6393890 + transcriptional regulator SC9B10.07%2C probable transcriptional regulator%2C len: 231 aa%3B similar to many eg. GNTR_BACSU P10585 gluconate operon transcriptional repressor (243 aa)%2C fasta scores%3B opt: 199 z-score: 264.8 E(): 1.4e-07%2C 26.2%25 identity in 195 aa overlap. Contains PS00043 Bacterial regulatory proteins%2C gntR family signature. Contains probable helix-turn-helix motif at aa positions 29-49 (Score 1133%2C +3.05 SD) gene gene5903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5840 SCO5841 SCO5841 ptsH ptsH 6394045 6394326 - phosphocarrier protein HPr SC9B10.08c%2C ptsH%2C phosphocarrier protein hpr%2C len: 93 aa%3B similar to many eg. PTHP_ECOLI P07006 phosphocarrier protein hpr (85 aa)%2C fasta scores%3B opt: 153 z-score: 226.5 E(): 1.9e-05%2C 31.0%25 identity in 84 aa overlap. Contains PS00369 PTS HPR component histidine phosphorylation site signature gene gene5904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5841 SCO5842 SCO5842 SC9B10.09 SC9B10.09 6394529 6397648 + hypothetical protein SC9B10.09%2C unknown%2C len: 1039%3B weak similarity to hypothetical proteins from M. jannaschii Y590_METJA Q58010 hypothetical protein mj0590 (704 aa)%2C fasta scores%3B opt: 377 z-score: 424.6 E(): 1.7e-16%2C 24.0%25 identity in 810 aa overlap%3B and E. coli YFIQ_ECOLI P76594 hypothetical 98.0 kd protein in ung-pssa intergenic region (886 aa)%2C fasta scores%3B opt: 267 z-score: 215.7 E(): 7.4e-05%2C 23.9%25 identity in 833 aa overlap. Contains 12 tandem repeats of the aa triplet SGP at aa positions 695 to 707%3B these are not present in Y590_METJA or YFIQ_ECOLI gene gene5905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5842 SCO5843 SCO5843 SC9B10.10 SC9B10.10 6397754 6398341 + hypothetical protein SC9B10.10%2C unknown%2C len: 195 aa gene gene5906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5843 SCO5844 SCO5844 SC9B10.11 SC9B10.11 6398341 6399534 + hypothetical protein SC9B10.11%2C unknown%2C len: 397 aa gene gene5907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5844 SCO5845 SCO5845 SC9B10.12 SC9B10.12 6399582 6400232 + thymidine kinase catalyzes the formation of thymidine 5'-phosphate from thymidine gene gene5908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5845 SCO5846 SCO5846 SC9B10.13c SC9B10.13c 6400262 6402331 - hypothetical protein SC9B10.13c%2C hypothetical protein%2C len: 689 aa. Contains possible N-terminal region signal peptide sequence gene gene5909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5846 SCO5847 SCO5847 SC9B10.14 SC9B10.14 6402599 6403366 + transcriptional regulator SC9B10.14%2C probable transcriptional regulator%2C len: 255 aa%3B weakly similar to many eg. FARR_ECOLI P13669 fatty acyl responsive regulator (240 aa)%2C fasta scores%3B opt: 220 z-score: 345.1 E(): 4.7e-12%2C 28.0%25 identity in 236 aa overlap. Contains PS00043 Bacterial regulatory proteins%2C gntR family signature gene gene5910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5847 SCO5848 SCO5848 agaZ agaZ 6403579 6404886 + tagatose 6-phosphate kinase SC9B10.15%2C agaZ%2C possible tagatose 6-phosphate kinase%2C len: 435%3B highly similar to AGAZ_ECOLI P42903 tagatose 6-phosphate kinase (426 aa)%2C fasta scores%3B opt: 1637 z-score: 2100.1 E(): 0%2C 57.5%25 identity in 421 aa overlap gene gene5911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5848 SCO5849 SCO5849 agaS agaS 6404883 6406040 + AgaS protein SC9B10.16%2C agaS%2C len: 385 aa%3B similar to AGAS_ECOLI P42907 agas protein (384 aa) (possible tagatose-6-phosphate ketose/aldose isomerase)%2C fasta scores%3B opt: 960 z-score: 1350.4 E(): 0%2C 45.9%25 identity in 366 aa overlap gene gene5912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5849 SCO5850 SCO5850 SC9B10.17 SC9B10.17 6406090 6407082 + hypothetical protein SC9B10.17%2C unknown%2C len: 330 aa%3B similar to TR:Q97U07 (EMBL:AE006910) hypothetical protein from Sulfolobus solfataricus (298 aa) fasta scores%3B opt: 370%2C Z-score: 414.6%2C E(): 1.8e-15%2C 31.596%25 identity (34.520%25 ungapped) in 307 aa overlap. gene gene5913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5850 SCO5851 SCO5851 SC9B10.18 SC9B10.18 6407079 6408017 + hypothetical protein SC9B10.18%2C possible integral membrane protein%2C len: 312 aa. Contains possible hydrophobic membrane spanning regions gene gene5914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5851 SCO5852 SCO5852 agaY agaY 6408122 6408970 + tagatose-bisphosphate aldolase SC9B10.19%2C agaY%2C possible tagatose-bisphosphate aldolase%2C len: 282 aa%3B similar to eg. AGAY_ECOLI P42908 tagatose-bisphosphate aldolase agaY (286 aa)%2C fasta scores%3B opt: 585 z-score: 725.0 E(): 3.2e-33%2C 37.6%25 identity in 279 aa overlap gene gene5915 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5852 SCO5853 SCO5853 SC9B10.20c SC9B10.20c 6409025 6409828 - hypothetical protein SC9B10.20c%2C unknown%2C len: 267 aa%3B similar to several hypothetical proteins eg.TR:Q55078 (EMBL:U50973) OrfA from Streptomyces sp. (275 aa)%2C fasta scores%3B opt: 418 z-score: 665.7 E(): 6.4e-30%2C 37.1%25 identity in 267 aa overlap gene gene5916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5853 SCO5854 SCO5854 SC9B10.21 SC9B10.21 6410064 6410915 + thiosulfate sulfurtransferase SC9B10.21%2C possible thiosulfate sulfurtransferase%2C len: 283 aa%3B similar to many eukaryotic and prokaryotic rhodaneses eg. THTR_HUMAN P25325 thiosulfate sulfurtransferase (EC 2.8.1.1) (296 aa)%2C fasta scores%3B opt: 403 z-score: 389.9 E(): 1.5e-14%2C 35.0%25 identity in 286 aa overlap gene gene5917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5854 SCO5855 SCO5855 SC9B10.22c SC9B10.22c 6411199 6412257 - DNA-binding protein SC9B10.22c%2C unknown%2C len: 352 aa%3B similar to hypothetical proteins from Mycobacteruim tuberculosis and M. leprae%3B YZ11_MYCTU Q10545 MTCY31.11c (253 aa)%2C fasta scores%3B opt: 444 z-score: 396.4 E(): 6.4e-15%2C 35.0%25 identity in 246 aa overlap. Contains probable helix-turn-helix domain at aa positions 70-91 (Score 1098%2C +2.93 SD) gene gene5918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5855 SCO5856 SCO5856 SC9B10.23 SC9B10.23 6412730 6413614 + hypothetical protein SC9B10.23%2C unknown ATP/GTP binding protein ( membrane protein)%2C len: 294 aa%3B contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible hydrophobic membrane spanning regions gene gene5919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5856 SCO5857 SCO5857 SC9B10.24c SC9B10.24c 6413538 6414875 - FAD-dependent oxidoreductase SC9B10.24c%2C probable FAD-dependent oxidoreductase%2C len: 445 aa%3B similar to several eg. GGLO_RAT P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439 aa)%2C fasta scores%3B opt: 854 z-score: 973.6 E(): 0%2C 33.6%25 identity in 440 aa overlap. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site%2C and possible transmembrane anchor at approx. 170-200 aa gene gene5920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5857 SCO5858 SCO5858 SC9B10.25c SC9B10.25c 6414817 6415998 - hypothetical protein SC9B10.25c%2C unknown%2C probable integral membrane protein%2C len: 393 aa%3B similar to TR:Q9I1K4 (EMBL:AE004652) Pseudomonas aeruginosa hypothetical protein PA2269%2C 401 aa%3B fasta scores: opt: 1176 Z-score: 1266.8 E(): 6.3e-63%3B 50.678%25 identity in 369 aa overlap gene gene5921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5858 SCO5859 SCO5859 hemH hemH 6416236 6417363 + ferrochelatase protoheme ferro-lyase%3B catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme%3B involved in protoheme biosynthesis%3B in some organisms this protein is membrane-associated while in others it is cytosolic gene gene5922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5859 SCO5860 SCO5860 SC9B10.27 SC9B10.27 6417372 6418190 + SuhB protein SC2E9.01%2C suhB%2C probable extragenic suppressor protein%2C partial CDS%2C len: >209 aa%2C similar to eg. SUHB_ECOLI P22783 extragenic suppressor protein Suhb (267 aa)%2C fasta scores%3B opt: 448 z-score: 565.9 E(): 2.5e-24%2C 41.0%25 identity in 212 aa overlap%2C and to eg. MYO2_LYCES P54927 myo-inositol-1(or 4)-monophosphatase (265 aa)%2C fasta scores%3B opt: 359 z-score: 450.8 E(): 6.6e-18%2C 38.7%25 identity in 199 aa overlap. Contains PS00629 and PS00630 Inositol monophosphatase family signatures 1 and 2 and Pfam match to entry inositol_P PF00459%2C Inositol monophosphatase family%2C score 64.03. Overlaps and extends ORF from neighbouring cosmid SC9B10.27~SC9B10.27%2C suhB gene homolog%2C partial CDS%2C len > 96 aa%3B similar to E.coli SUHB_ECOLI P22783 extragenic suppressor protein Suhb (267 aa)%2C fasta scores%3B opt: 186 z-score: 333.9 E(): 1.9e-11%2C 40.0%25 identity in 85 aa overlap%3B and to MYOP_HUMAN P29218 myo-inositol-1(or 4)-monophosphatase (277 aa)%2C fasta scores%3B opt: 180 z-score: 267.3 E(): 9.9e-08%2C 37.2%25 identity in 94 aa overlap gene gene5923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5860 SCO5861 SCO5861 SC2E9.02 SC2E9.02 6418515 6419081 + hypothetical protein SC2E9.02%2C unknown%2C len: 188 aa%3B not predicted by FramePlot gene gene5924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5861 SCO5862 SCO5862 cutR cutR 6419308 6419961 + two-component regulator CutR SC2E9.03%2C cutR%2C two-component regulator CutR%2C len: 217 aa%3B identical to CUTR_STRLI Q03756 transcriptional regulatory protein CutR from Streptomyces lividans (217 aa). Contains Pfam match to entry trans_reg_C PF00486%2C Transcriptional regulatory proteins%2C C terminal%2C score 74.36 gene gene5925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5862 SCO5863 SCO5863 cutS cutS 6419968 6421212 + two-component sensor (kinase) SC2E9.04%2C cutS%2C two-component sensor (kinase)%2C len: 414 aa%3B identical to SW:CUTS_STRLI (EMBL:Q03757) CutS protein from Streptomyces lividans (414 aa). Contains Pfam match to entry signal PF00512%2C Signal C terminal domain%2C score 191.45. Contains possible hydrophobic membrane spanning regions gene gene5926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5863 SCO5864 SCO5864 SC2E9.05 SC2E9.05 6421618 6421914 + hypothetical protein SC2E9.05%2C unknown%2C len: 98 aa%3B highly similar to hypothetical proteins from Mycobacterium tuberculosis and M. leprae eg. TR:O07201 (EMBL:Z96072) MTCY05A6.20C (100 aa)%2C fasta scores%3B opt: 465 z-score: 814.5 E(): 0%2C 71.4%25 identity in 98 aa overlap gene gene5927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5864 SCO5865 SCO5865 SC2E9.06 SC2E9.06 6421928 6422881 + hypothetical protein SC2E9.06%2C unknown%2C len: 317 aa gene gene5928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5865 SCO5866 SCO5866 SC2E9.07c SC2E9.07c 6422895 6423359 - hypothetical protein SC2E9.07c%2C membrane protein%2C len: 154 aa%3B similar to hypothetical proteins from Mycobacterium tuberculosis and M. leprae e.g. TR:O07200 (EMBL:Z96072) MTCY05A6.19 (161 aa)%2C fasta scores%3B opt: 230 z-score: 264.3 E(): 1.6e-07%2C 35.7%25 identity in 154 aa overlap. Contains possible hydrophobic membrane spanning region gene gene5929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5866 SCO5867 SCO5867 SC2E9.08 SC2E9.08 6423417 6424001 + hypothetical protein SC2E9.08%2C unknown%2C len: 194 aa gene gene5930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5867 SCO5868 SCO5868 dut dut 6423998 6424549 + deoxyuridine 5'-triphosphate nucleotidohydrolase catalyzes the formation of dUMP from dUTP gene gene5931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5868 SCO5869 SCO5869 SC2E9.10 SC2E9.10 6424551 6425303 + hypothetical protein SC2E9.10%2C unknown%2C len: 250 aa%3B similar to hypothetical proteins from Mycobacterium tuberculosis and M. leprae eg. TR:O07198 (EMBL:Z96072) MTCY05A6.17C (259 aa)%2C fasta scores%3B opt: 213 z-score: 435.8 E(): 4.5e-17%2C 28.2%25 identity in 255 aa overlap. Contains possible coiled-coil domain from aa 1-40 gene gene5932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5869 SCO5870 SCO5870 SC2E9.11 SC2E9.11 6425493 6426185 + ABC transporter ATP-binding protein SC2E9.11%2C probable ABC-transporter ATP binding protein%2C len: 230 aa%3B highly similar to many eg. Y796_METJA Q58206 hypothetical abc transporter atp-binding protein (235 aa)%2C fasta scores%3B opt: 666 z-score: 870.6 E(): 0%2C 43.8%25 identity in 226 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and Pfam match to entry ABC_tran PF00005%2C ABC transporters%2C score 54.33 gene gene5933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5870 SCO5871 SCO5871 kdpD kdpD 6426319 6428865 + turgor pressure sensor SC2E9.12%2C kdpD%2C two-component sensor/protein kinase%2C len: 848 aa%3B similar to Escherichia coli turgor pressure sensor KDPD_ECOLI P21865 sensor protein kdpD (ec 2.7.3.-) (894 aa)%2C fasta scores%3B opt: 997 z-score: 1347.4 E(): 0%2C 34.8%25 identity in 877 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry signal PF00512%2C Signal C terminal domain%2C score 184.57. Contains possible hydrophobic membrane spanning regions gene gene5934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5871 SCO5872 SCO5872 kdpE kdpE 6428862 6429545 + turgor pressure regulator SC2E9.13%2C kdpE%2C two-component trascriptional regulator%2C len: 227%2C similar to E.coli turgor pressure regulator KDPE_ECOLI P21866 kdp operon transcriptional regulatory protein (225 aa)%2C fasta scores%3B opt: 752 z-score: 1090.9 E(): 0%2C 51.1%25 identity in 225 aa overlap. Contains Pfam match to entry trans_reg_C PF00486%2C Transcriptional regulatory proteins%2C C terminal%2C score 96.22 gene gene5935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5872 SCO5873 SCO5873 SC2E9.14 SC2E9.14 6429542 6430006 + hypothetical protein SC2E9.14%2C unknown%2C len: 154 aa%3B similar to Mycobacterium tuberculosis hypothetical protein TR:O07196 (EMBL:Z96072) MTCY05A6.15C (122 aa)%2C fasta scores%3B opt: 299 z-score: 502.1 E(): 9.1e-21%2C 41.0%25 identity in 117 aa overlap gene gene5936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5873 SCO5874 SCO5874 SC2E9.15 SC2E9.15 6430010 6430828 + hypothetical protein SC2E9.15%2C membrane protein%2C len: 272 aa%3B similar to Mycobacterium tuberculosis hypothetical protein TR:O07195 (EMBL:Z96072) MTCY05A6.14C (223 aa)%2C fasta scores%3B opt: 212 z-score: 285.5 E(): 1.1e-08%2C 23.5%25 identity in 247 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene5937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5874 SCO5875 SCO5875 SC2E9.16c SC2E9.16c 6430947 6431627 - potassium uptake protein SC2E9.16c%2C possible potassium uptake protein%3B len: 226 aa%3B similar to many homologs of trkA eg. Mycobacterium tuberculosis TR:O07194 (EMBL:Z96072) MTCY05A6.13 (220 aa)%2C fasta scores%3B opt: 870 z-score: 1486.1 E(): 0%2C 58.8%25 identity in 216 aa overlap. Also similar to upstream ORF SC2E9.17c%2C trkA%2C (E(): 1.8e-05%2C 22.6%25 identity in 212 aa overlap) gene gene5938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5875 SCO5876 SCO5876 trkA trkA 6431627 6432298 - potassium uptake protein SC2E9.17c%2C trkA%2C potassium uptake protein%2C len: 223 aa%3B similar to first domain of TRKA_ECOLI P23868 Trk system potassium uptake protein (458 aa)%2C fasta scores%3B opt: 249 z-score: 389.9 E(): 1.6e-14%2C 28.6%25 identity in 227 aa overlap. Also similar to downstream ORF SC2E9.16c (E(): 0.00062%2C 22.6%25 identity in 212 aa overlap) gene gene5939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5876 SCO5877 SCO5877 redD redD 6432566 6433618 + transcriptional regulator RedD SC2E9.18%2C redD%2C transcriptional regulator%2C len: 350 aa%3B identical to REDD_STRCO P16922 redd protein from Streptomyces coelicolor (350 aa). Possible alternative start site at 15238 (aa 84) gene gene5940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5877 SCO5878 SCO5878 redX redX 6433668 6436616 + polyketide synthase RedX SC2E9.19%2C redX%2C polyketide synthase with two beta-ketoacyl synthase domains%2C len: 982 aa%3B similar to many eg. ERY3_SACER Q03133 erythronolide synthase%2C modules 5 and 6 (3170 aa)%2C fasta scores%3B opt: 649 z-score: 586.3 E(): 1.9e-25%2C 29.2%25 identity in 1029 aa overlap. Contains 2 x Pfam match to entry ketoacyl-synt PF00109%2C Beta-ketoacyl synthases%2C scores 52.40 and 310.80 gene gene5941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5878 SCO5879 SCO5879 redW redW 6436613 6437788 + acyl-coa dehydrogenase RedW SC2E9.20%2C redW%2C acyl-coa dehydrogenase%2C len: 391%3B similar to many eg. ACDB_BACSU P45857 acyl-coa dehydrogenase (ec 1.3.99.-) (379 aa)%2C fasta scores%3B opt: 831 z-score: 1005.0 E(): 0%2C 40.7%25 identity in 371 aa overlap. Contains Pfam match to entry Acyl-CoA_dh PF00441%2C Acyl-CoA dehydrogenases%2C score 308.86 gene gene5942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5879 SCO5880 SCO5880 redY redY 6437814 6438134 + RedY protein SC2E9.21%2C redY%2C unknown function%2C len: 106 gene gene5943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5880 SCO5881 SCO5881 redZ redZ 6438206 6438859 - response regulator SC2E9.22c%2C redZ%2C response regulator%2C partial CDS%2C len: >67 aa%3B identical to TR:P72402 (EMBL:Y07902) RedZ gene (217 aa). Contains probable helix-turn-helix motif at aa 12 to 33 (Score 1209%2C +3.30 SD)~SC3F7.01c%2C redZ%2C response regulator%2C partial CDS%2C len >184 aa%3B identical to TR:P72402 (EMBL:Y07902) redZ gene (217 aa)%2C and similar to many two-component regulators e.g. UVRY_ECOLI P07027 UvrY protein from Escherichia coli (218 aa)%2C fasta scores%3B opt: 159 z-score: 291.2 E(): 5e-09%2C 26.3%25 identity in 186 aa overlap. Contains TTA leucine codon%3B a potential target for action of bldA%2C probable Helix-turn-helix motif at aa 162-183 (Score 1209%2C +3.30 SD) and Pfam match to entry response_reg PF00072%2C Response regulator receiver domain%2C score 31.36 gene gene5944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5881 SCO5882 SCO5882 redV redV 6439123 6440310 - RedV protein SC3F7.02c%2C redV%2C function unknown%2C len: 395 aa gene gene5945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5882 SCO5883 SCO5883 redU redU 6440423 6441208 - hypothetical protein SC3F7.03c%2C redU%2C unknown%2C len: 261 aa gene gene5946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5883 SCO5884 SCO5884 SC3F7.04c SC3F7.04c 6441276 6442166 - hypothetical protein SC3F7.04c%2C unknown%2C len: 296 aa%3B some similarity to Archaeoglobus fulgidus hypothetical protein TR:G2648734 (EMBL:AE000977) AF1816 (300 aa)%2C fasta scores%3B opt: 314 z-score: 322.6 E(): 8.9e-11%2C 30.2%25 identity in 301 aa overlap gene gene5947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5884 SCO5885 SCO5885 SC3F7.05c SC3F7.05c 6442174 6442614 - hypothetical protein SC3F7.05c%2C membrane protein%2C len: 146 aa. Contains possible hydrophobic membrane spanning regions gene gene5948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5885 SCO5886 SCO5886 redR redR 6442753 6443976 - 3-oxoacyl-ACP synthase SC3F7.06c%2C redR%2C probable 3-oxoacyl-[acyl-carrier-protein] synthase II%2C len: 407 aa%3B similar to many eg. FABF_ECOLI P39435 3-oxoacyl-[acyl-carrier-protein] synthase II (EC 2.3.1.41) (beta-ketoacyl-acp synthase II) (412 aa)%2C fasta scores%3B opt: 1054 z-score: 1061.9 E(): 0%2C 42.0%25 identity in 412 aa overlap. Also some similarity to SC3F7.12 from aa 800 to 1210 (E(): 3.3e-10%2C 32.2%25 identity in 432 aa overlap). Contains Pfam match to entry ketoacyl-synt PF00109%2C Beta-ketoacyl synthases%2C score 243.99 gene gene5949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5886 SCO5887 SCO5887 redQ redQ 6443973 6444218 - acyl carrier protein SC3F7.07c%2C redQ%2C probable acyl carrier protein%2C len%3B 81 aa%3B similar to several eg. ACP_SYNY3 P20804 acyl carrier protein (acp) from Synechocystis (77 aa)%2Cfasta scores%3B opt: 153 z-score: 256.6 E(): 4.2e-07%2C 34.7%25 identity in 72 aa overlap gene gene5950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5887 SCO5888 SCO5888 redP redP 6444587 6445594 + 3-oxoacyl-ACP synthase III FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs gene gene5951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5888 SCO5889 SCO5889 redO redO 6445654 6445917 + hypothetical protein SC3F7.09%2C redO%2C unknown%2C len: 87 aa gene gene5952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5889 SCO5890 SCO5890 redN redN 6445914 6447836 + 8-amino-7-oxononanoate synthase SC3F7.10%2C redN%2C 8-amino-7-oxononanoate synthase%2C len: 640 aa%3B similar to many diverse transferases eg. BIOF_BACSH P22806 8-amino-7-oxononanoate synthase (389 aa)%2C fasta scores%3B opt: 926 z-score: 888.4 E(): 0%2C 42.1%25 identity in 361 aa overlap. Also simlar to SC3F7.12 from aa 1700 to end (E(): 3.6e-15%2C 31.9%25 identity in 630 aa overlap). Contains Pfam match to entry aminotran_2 PF00222%2C Aminotransferases class-II%2C score 292.92 in C-terminus gene gene5953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5890 SCO5891 SCO5891 redM redM 6447950 6449548 + peptide synthase St3F7.11%2C redM%2C probable peptide synthase%2C len: 532 aa%3B similar to part of many peptide synthases eg. Myxococcus xanthus TR:Q50858 (EMBL:U24657) saframycin MX1 synthetase A (2605 aa)%2C fasta scores%3B opt: 572 z-score: 782.6 E(): 0%2C 36.1%25 identity in 548 aa overlap. Contains PS00455 AMP-binding domain signature and Pfam match to entry AMP-binding PF00501%2C AMP-binding enzymes%2C score 392.99. Also similar to part of SC3F7.12 aa 60 to 590 (E(): 2.8e-05%2C 25.3%25 identity in 561 aa overlap) gene gene5954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5891 SCO5892 SCO5892 redL redL 6449549 6456442 + polyketide synthase SC3F7.12%2C redL%2C probable polyketide synthase%2C len: 2297 aa%3B contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores%3B E(): 0%2C 45.0%25 identity in 691 aa overlap)%2C contains Pfam match to AMP-binding PF00501%2C AMP-binding enzymes%2C score 166.66%3B central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0%2C 39.9%25 identity in 1125 aa overlap)%2C contains PS00606 Beta-ketoacyl synthases active site and Pfam match to ketoacyl-synt PF00109%2C Beta-ketoacyl synthases%2C score 585.24%3B and C-terminus (approx aa 1800 to end)%2C similar to eg. TR:Q52936 (EMBL:X64131 acyl-transferase rkpG from Rhizobium meliloti (446 aa) (E(): 0. 44.9%25 identity in 394 aa overlap)%2C contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site and Pfam match to aminotran_2 PF00222%2C Aminotransferases class-II%2C score 276.93 gene gene5955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5892 SCO5893 SCO5893 redK redK 6456446 6457489 + oxidoreductase SC3F7.13%2C redK%2C probable oxidoreductase%2C len: 347 aa%3B similar to many eukaryotic steroid dehydrogenases eg. TR:Q62878 (EMBL:L17138) 3 hydroxysteroid dehydrogenase from Rattus norvegicus (373 aa)%2C fasta scores%3B opt: 103 z-score: 378.9 E(): 6.6e-14%2C 30.4%25 identity in 355 aa overlap%3B and to Mycobacterium tuberculosis dehydrogenase TR:O06373 (EMBL:Z95436) MTCY15C10.18 (314 aa)%2C fasta scores%3B opt: 204 z-score: 417.9 E(): 4.4e-16%2C 27.7%25 identity in 339 aa overlap gene gene5956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5893 SCO5894 SCO5894 redJ redJ 6457476 6458318 + thioesterase SC3F7.14%2C redJ%2C probable thioesterase%2C len: 280 aa%3B similar to many e.g. TR:Q00442 (EMBL:X60379) erythomycin A biosynthesis thioesterase (EC 3.1.-.-.) from Saccharopolyspora erythraea (Streptomyces erythraeus) (247 aa)%2C fasta scores%3B opt: 451 z-score: 472.9 E(): 3.8e-19%2C 38.0%25 identity in 237 aa overlap gene gene5957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5894 SCO5895 SCO5895 redI redI 6458306 6459394 + methyltransferase SC3F7.15%2C redI%2C possible methyltransferase%2C len: 362 aa%3B weakly similar to several e.g. Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa)%2C fasta scores%3B opt: 130 z-score: 204.9 E(): 0.00032%2C 27.6%25 identity in 192 aa overlap gene gene5958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5895 SCO5896 SCO5896 redH redH 6459417 6462218 + phosphoenolpyruvate-utilizing enzyme SC10A5.01%2C redH%2C probable phosphoenolpyruvate-utilizing enzyme%2C partial CDS%2C len: >95 aa%3B overlaps and extends ORF from neighbouring cosmid SC3F7.16%3B similar to many eg. PPSA_STAMA P46893 probable phosphoenolpyruvate synthase (834 aa)%2C fasta scores%3B opt: 215 z-score: 351.4 E(): 2.3e-12%2C 47.8%25 identity in 69 aa overlap~SC3F7.16%2C probable phosphoenolpyruvate-utilizing enzyme%2C partial CDS%2C len: >872 aa%3B similar to many eg. PPSA_STAMA P46893 probable phosphoenolpyruvate synthase from Staphylothermus marinus (834 aa)%2C fasta scores%3B opt: 392 z-score: 614.9 E(): 4.7e-27%2C 33.0%25 identity in 309 aa overlap. Contains Pfam match to entry PEP-utilizers PF00391%2C PEP-utilizing enzymes%2C score 23.96 gene gene5959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5896 SCO5897 SCO5897 redG redG 6462296 6463483 + oxidase SC10A5.02%2C redG%2C probable oxidase%2C len: 395 aa%3B similar in N- terminus to many diverse oxidases e.g. TR:P95483 (EMBL:U7449 3) aminopyrrolnitrin oxidase PrnD from Pseudomonas fluorescens (363 aa)%2C fasta scores%3B opt: 349 z-score: 372.1 E(): 1. 6e-13%2C 33.3%25 identity in 165 aa overlap gene gene5960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5897 SCO5898 SCO5898 redF redF 6463526 6464206 + hypothetical protein SC10A5.03%2C redF%2C probable membrane protein%2C len: 226 aa. Contains possibe hydrophobic membrane spanning regions gene gene5961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5898 SCO5899 SCO5899 SC10A5.04 SC10A5.04 6464371 6465258 + hypothetical protein SC10A5.04%2C unknown%2C len: 295 aa%3B similar to hypothetical proteins from Mycobacterioum tuberculosis and M. leprae e.g. YV29_MYCTU Q11167 hypothetical 39.3 kd protein CY20G9.29 (358 aa)%2C fasta scores%3B opt: 1075 z-score: 1514.7 E(): 0%2C 57.8%25 identity in 263 aa overlap gene gene5962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5899 SCO5900 SCO5900 SC10A5.05 SC10A5.05 6465627 6467702 + hypothetical protein SC10A5.05%2C probable membrane protein%2C len: 691%3B high ly similar to M. tuberculosis membrane protein TR: O07192 (EMBL:Z96072) MTCY05A6.11C (647 aa)%2C fasta scores%3B o pt: 1980 z-score: 3557.6 E(): 0%2C 62.7%25 identity in 659 aa o verlap and weakly similar to many transport proteins eg. PR OY_SALTY P37460 proline-specific permease proy from Salmone lla typhimurium (456 aa)%2C fasta scores%3B opt: 169 z-score: 1 82.8 E(): 0.0055%2C 24.2%25 identity in 355 aa overlap gene gene5963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5900 SCO5901 SCO5901 SC10A5.06 SC10A5.06 6467755 6469131 + RNA methyltransferase SC10A5.06%2C unknown%2C len: 458%3B similar to M. tuberculosis hypothetical protein TR:O07191 (EMBL:Z96072) MTCY05A6. 10C (405 aa)%2C fasta scores%3B opt: 455 z-score: 878.5 E(): 0%2C 38.4%25 identity in 417 aa overlap%2C and weakly similar to several RNA methyltransferases eg. YGCA_ECOLI P5513 5 hypothetical RNA methyltransferase (433 aa)%2C fasta scores %3B opt: 358 z-score: 331.2 E(): 3e-11%2C 27.4%25 identity in 441 aa overlap gene gene5964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5901 SCO5902 SCO5902 SC10A5.07 SC10A5.07 6469741 6469851 + gene gene5965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5902 SCO5903 SCO5903 SC10A5.08 SC10A5.08 6469848 6470225 + gene gene5966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5903 SCO5904 SCO5904 SC10A5.09c SC10A5.09c 6470494 6470874 - hypothetical protein SC10A5.09c%2C unknown%2C len: 126 aa%3B similar to Mycobac terium tuberculosis hypothetical protein TR:O06156 (EMBL:Z9 5555) MTCY06F7.02C (105 aa)%2C fasta scores%3B opt: 125 z-score : 213.5 E(): 0.00011%2C 37.7%25 identity in 69 aa overlap gene gene5967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5904 SCO5905 SCO5905 SC10A5.10c SC10A5.10c 6470909 6473452 - export protein SC10A5.10c%2C probable export protein%2C len: 847 aa%3B similar to eg. S. coelicolor actinorhodin antibiotic export protein TR:Q53902 (EMBL:M64683) ORF2 (ACTII) (711 aa)%2C fasta scores%3B opt: 705 z-score: 1126.2 E(): 0%2C 35.4%25 identity in 746 aa overlap gene gene5968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5905 SCO5906 SCO5906 SC10A5.11 SC10A5.11 6473606 6474202 + transcriptional regulator SC10A5.11%2C probable transcriptional regulator%2C len: 198 aa%3B similar to many members of the tetR family eg. TR:P72569 (EMBL:U58281) TetR homologue WhiR from Streptomyces roseosporus (179 aa)%2C fasta scores%3B opt: 367 z-score: 569.5 E(): 1.6e-24%2C 38.3%25 identity in 175 aa overlap. Contains pr obable helix-turn-helix motif at aa 37 to 58 (Score 1635%2C +4.76SD) gene gene5969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5906 SCO5907 SCO5907 SC10A5.12c SC10A5.12c 6474317 6474436 - hypothetical protein SC10A5.12c%2C unknown%2C len: 39 aa gene gene5970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5907 SCO5908 SCO5908 SC10A5.13 SC10A5.13 6474517 6474711 + hypothetical protein SC10A5.13%2C unknown%2C len: 64 aa gene gene5971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5908 SCO5909 SCO5909 SC10A5.14 SC10A5.14 6474708 6474914 + hypothetical protein SC10A5.14%2C unknown%2C len: 68 aa gene gene5972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5909 SCO5910 SCO5910 SC10A5.15 SC10A5.15 6474947 6475291 + hypothetical protein SC10A5.15%2C membrane protein%2C len: 114 aa. Contains possible hydrophobic membrane spanning regions gene gene5973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5910 SCO5911 SCO5911 SC10A5.16c SC10A5.16c 6475426 6476991 - oligopeptide binding protein SC10A5.16c%2C possible oligopeptide binding protein%2C len: 521%3B weak similarity to many eg. OPPA_SALTY P06202 periplasmic oligopeptide-binding protein (542 aa)%2C fasta scores%3B opt: 343 z-score: 306.2 E(): 7.4e-10%2C 25.0%25 i dentity in 537 aa overlap. Contains N-terminal signal seque nce gene gene5974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5911 SCO5912 SCO5912 SC10A5.17 SC10A5.17 6477438 6480035 + protease SC10A5.17%2C probable protease%2C len: 865 aa%3B similar to many members of the peptidase family M9 (zinc me talloprotease) eg. COLA_VIBAL P43154 microbial collagenase precursor from VIBRIO ALGINOLYTICUS (814 aa)%2C fasta scores%3B opt: 1357 z-score: 1196.6 E(): 0%2C 36.0%25 identity in 773 aa overlap. Contains N-terminal signal sequence and PS00142 N eutral zinc metallopeptidases%2C zinc-binding region signatur e gene gene5975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5912 SCO5913 SCO5913 SC10A5.18 SC10A5.18 6480200 6481435 + protease SC10A5.18%2C probable protease%2C len: 411 aa%3B similar to many members of the peptidase family S2A eg. PRT C_STRGR P52320 serine protease c precursor (ec 3.4.21.-) (4 57 aa)%2C fasta scores%3B opt: 326 z-score: 460.9 E(): 1.8e-18%2C 29.8%25 identity in 420 aa overlap. Contains N-terminal sign al sequence and PS00134 Serine proteases%2C trypsin family%2C h istidine active site. Also contains TTA leucine codon%2C a po tential target for action of bldA gene gene5976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5913 SCO5914 SCO5914 SC10A5.19c SC10A5.19c 6481608 6482600 - transcriptional regulator SC10A5.19c%2C probable transcriptional regulator%2C len: 330 aa%3B similar to many membres of the LysR family e.g. MPR R_STRCO P43160 small neutral protease regulatory protein (316 aa)%2C fasta cores%3B opt: 510 z-score: 581.6 E(): 3.4e-25%2C 35.8%25 identity in 324 aa overlap. Contains PS00044 Bacterial regulatory proteins%2C lysR family signature gene gene5977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5914 SCO5915 SCO5915 SC10A5.20 SC10A5.20 6482843 6483358 + hypothetical protein SC10A5.20%2C unknown%2C len: 171 aa%3B weak similarity to part of TR:P79078 (EMBL:Y10421) DELTA-9 FATTY ACID DESATURA SE (EC 1.14.99.5) from CRYPTOCOCCUS CURVATUS (555 aa)%2C fast a scores%3B opt: 83 z-score: 221.8 E(): 3.7e-05%2C 25.1%25 identi ty in 171 aa overlap gene gene5978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5915 SCO5916 SCO5916 SC10A5.21 SC10A5.21 6483675 6484187 + hypothetical protein SC10A5.21%2C unknown%2C len: 170 aa%3B contains probable helix-turn-helix motif at aa 90 to 111 (Score 1413%2C +4.00 SD) gene gene5979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5916 SCO5917 SCO5917 SC10A5.22 SC10A5.22 6484965 6485303 + hypothetical protein SC10A5.22%2C unknown%2C len: 112 aa%3B weakly similar to S . coelicolor HSPR_STRCO P40183 heat shock protein hspr (151 aa)%2C fasta scores%3B opt: 153 z-score: 212.0 E(): 0 .00013%2C 31.7%25 identity in 101 aa overlap gene gene5980 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5917 SCO5918 SCO5918 SC10A5.23c SC10A5.23c 6486961 6487272 - hypothetical protein SC10A5.23c%2C unknown%2C len: 103 aa gene gene5981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5918 SCO5919 SCO5919 SC10A5.24c SC10A5.24c 6487321 6487725 - hypothetical protein SC10A5.24c%2C unknown%2C len: 134 aa gene gene5982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5919 SCO5920 SCO5920 SC10A5.25c SC10A5.25c 6487772 6489268 - DEAD/DEAH box helicase SC10A5.25c%2C probable DEAD-box RNA helicase%2C len: 498 aa%3B similar to many e.g. RHLE_ECOLI P25888 ATP-dependent RNA helicase RhlE (454 aa)%2C fasta scores%3B opt: 845 z -score: 770.8 E(): 0%2C 36.2%25 identity in 434 aa overlap. Con tains possible DEAD-box at aa 221-224 (1 mismatch to prosit e consensus)%2C 2x PS00017 ATP/GTP-binding site motif A (P-lo op) and PS00135 Serine proteases%2C trypsin family%2C serine ac tive site%2C though the last may be spurious. Also contains P fam match to entry helicase_C PF00271%2C Helicases conserved C-terminal domain%2C score 108.77 and Pfam match to entry DEA D PF00270%2C DEAD and DEAH box helicases%2C score 236.10 gene gene5983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5920 SCO5921 SCO5921 SC10A5.26c SC10A5.26c 6489617 6489820 - cold-shock domain-containing protein SC10A5.26c%2C scoF5%2C cold-shock domain protein%2C len: 67 aa%3B highly similar to many e.g. CSPF_STRCO P48859 cold shock protein ScoF from S. coelicolor (67 aa)%2C fasta scores%3B opt: 383 z-score: 750.4 E(): 0%2C 82.1%25 identity in 67 aa overlap. Contains PS00352 'Cold-shock' DNA-binding domain signature gene gene5984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5921 SCO5922 SCO5922 SC10A5.27c SC10A5.27c 6490462 6491442 - short chain dehydrogenase SC10A5.27c%2C possible oxidoreductase%2C len: 326 aa%3B some similarity to many members of the SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY (SDR) eg. YGFF_ECOLI P52037 hypothet ical oxidoreductase (247 aa)%2C fasta scores%3B opt: 96 z-score : 310.6 E(): 4.2e-10%2C 29.1%25 identity in 213 aa overlap. Con tains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene5985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5922 SCO5923 SCO5923 SC10A5.28c SC10A5.28c 6492065 6493150 - ABC transporter ATP-binding protein gene gene5986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5923 SCO5924 SCO5924 SC10A5.29c SC10A5.29c 6493143 6494912 - hypothetical protein SC10A5.29c%2C probable integral membrane protein%2C len: 589 aa%3B similar to many permeases eg. TR:Q44123 (EMBL:U050 42) iron utilisation protein AFUB from Actinobacillus pleur opneumoniae (687 aa)%2C fasta scores%3B opt: 564 z-score: 426.3 E(): 1.5e-16%2C 25.0%25 identity in 547 aa overlap gene gene5987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5924 SCO5925 SCO5925 SC10A5.30c SC10A5.30c 6494967 6495218 - hypothetical protein SC10A5.30c%2C unknown%2C len: 83 aa gene gene5988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5925 SCO5926 SCO5926 SC10A5.31c SC10A5.31c 6495215 6495736 - hypothetical protein SC10A5.31c%2C unknown%2C len: 173 aa%3B highly similar to the C-terminus of many prokaryotic and eukaryotic aconitase s eg. ACO1_ECOLI P25516 aconitate hydratase 1 (ec 4.2.1.3) (890 aa)%2C fasta scores%3B opt: 422 z-score: 567.1 E(): 2.2e-2 4%2C 49.3%25 identity in 138 aa overlap gene gene5989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5926 SCO5927 SCO5927 SC10A5.32c SC10A5.32c 6495872 6496093 - hypothetical protein SC10A5.32c%2C unknown%2C len: 73 gene gene5990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5927 SCO5928 SCO5928 SC10A5.33c SC10A5.33c 6496282 6496986 - hypothetical protein SC10A5.33c%2C unknown%2C len: 234 aa gene gene5991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5928 SCO5929 SCO5929 SC10A5.34c SC10A5.34c 6497455 6498231 - oxidoreductase SC10A5.34c%2C possible oxidoreductase%2C len: 258 aa%3B very weakly similar to many eg. TR:G2673979 (EMBL:U94980) 2%2C4 -DIENOYL-COA REDUCTASE (HUMAN) (335 aa)%2C fasta scores%3B opt: 167 z-score: 231.2 E(): 1.1e-05%2C 21.2%25 identity in 208 aa overlap. Contains PS01070 DNA/RNA non-specific endonucleases active site gene gene5992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5929 SCO5930 SCO5930 SC10A5.35 SC10A5.35 6498298 6499377 + NTP pyrophosphohydrolase SC10A5.35%2C possible NTP pyrophosphohydrolase%2C len: 3 59 aa%3B similar to TR:Q53738 (EMBL:X92429) NTP pyrophosphohydrolase PUR7 from S. alboniger (152 aa)%2C fasta scores%3B opt: 467 z-score: 614.5 E(): 5e-27%2C 54.8%25 identity in 135 aa overlap. Contains PS00893 mutT domain signature gene gene5993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5930 SCO5931 SCO5931 SC10A5.36c SC10A5.36c 6499512 6500945 - xylanase A SC10A5.36c%2C xlnA%2C xylanase A precursor%2C partial CDS%2C len >383 aa%3B overlaps and extends ORF from neighbouring cosmid SC7H1.01c%3B almost identical to XYNA_STRLI P26514 endo- 1%2C4-beta-xylanase a precursor (477 aa) (99.2%25 identity in 383 aa overlap). Conatains PS00591 Glycosyl hydrolases famil y 10 active site and Pfam match to entry glycosyl_hydro3 PF 00331%2C Glycosyl hydrolases family 10%2C score 183.41. Also si milar in part to S. coelicolor SC7H1.02%2C abfB%2C arabinofuran osidase (E(): 1.4e-35%2C 58.4%25 identity in 149 aa overlap)~SC7H1.01c%2C xlnA%2C xylanase A precursor%2C partial CDS%2C len >147 aa%3B almost identical to S. lividans XYNA_STRLI P26514 endo-1%2C4-beta-xylanase a precursor (ec 3.2.1.8) (XYLANASE A) (477 aa)%2C fasta scores%3B opt: 926 z-score: 1591.1 E(): 0%2C 97.9%25 identity in 146 aa overlap. Contains N-terminal signal sequence and Pfam match to entry glycosyl_hydro3 PF00331%2C Glycosyl hydrolases family 10%2C score 107.60 gene gene5994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5931 SCO5932 SCO5932 abfB abfB 6501336 6502763 + arabinofuranosidase SC7H1.02%2C abfB%2C arabinofuranosidase precursor%2C len: 475 aa%3B almost identical to S. lividans TR:P96463 (EMBL:M64551) arabinofuranosidase precursor (EC 3.2.1.55)(alpha-l-arabinofuranosidase) (arabinosidase) (478 aa)%2C fasta scores%3B opt: 3129 z-score: 1807.5 E(): 0%2C 95.8%25 identity in 477 aa overlap. Contains N-terminal signal sequence gene gene5995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5932 SCO5933 SCO5933 SC7H1.03c SC7H1.03c 6502747 6503922 - hypothetical protein SC7H1.03c%2C possible membrane protein%2C len: 391 aa%3B C-terminal part similar to TR:Q9L0E7 (EMBL:AL161803) Streptomyces coelicolor hypothetical protein SCD31.20%2C 181 aa%3B fasta scores: opt: 592 Z-score: 665.9 E(): 1.8e-29%3B 53.514%25 identity in 185 aa overlap. Contains possible hydrophobic membrane spanning regions. Contains PS00213 Lipocalin signature%2C though this may be spurious gene gene5996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5933 SCO5934 SCO5934 SC7H1.04 SC7H1.04 6504150 6504752 + sigma factor SC7H1.04%2C possible sigma factor%2C len: 200 aa%3B some similarity to sigma factors (ECF subfamily) from diverse organisms e.g. Alcaligenes eutrophus CNRH_ALCEU P37978 rna polymerase sigma factor cnrh (191 aa)%2C fasta scores%3B opt: 230 z-score: 337.3 E(): 1.4e-11%2C 29.5%25 identity in 183 aa overlap gene gene5997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5934 SCO5935 SCO5935 SC7H1.05 SC7H1.05 6504749 6505642 + hypothetical protein SC7H1.05%2C membrane protein%2C len: 297 aa. Contains possible hydrophobic membrane spanning region gene gene5998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5935 SCO5936 SCO5936 SC7H1.06 SC7H1.06 6505626 6505787 - hypothetical protein SC7H1.06%2C unknown%2C len: 53 aa gene gene5999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5936 SCO5937 SCO5937 SC7H1.07c SC7H1.07c 6505802 6506170 - hypothetical protein SC7H1.07c%2C unknown%2C len: 122 aa gene gene6000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5937 SCO5938 SCO5938 SC7H1.08c SC7H1.08c 6506167 6506775 - hypothetical protein SC7H1.08c%2C unknown%2C len: 202 aa%3B some similarity in C-terminus to Mycobacterium tuberculosis hypothetical protein TR:P71839 (EMBL:Z80226) MTCY369.30C (129 aa)%2C fasta scores%3B opt: 240 z-score: 383.0 E(): 3.8e-14%2C 41.2%25 identity in 102 aa overlap gene gene6001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5938 SCO5939 SCO5939 SC7H1.09 SC7H1.09 6506808 6507281 + peptidylprolyl isomerase SC7H1.09%2C probable peptidylprolyl isomerase%2C len: 157 aa%3B similar to many eg. Streptomyces chrysomallus TR:P77949 (EMBL:U64692) cyclophilin sccypb (EC 5.2.1.8) (peptidylprolyl isomerase) (175 aa)%2C fasta scores%3B opt: 402 z-score: 552.5 E(): 1.4e-23%2C 49.6%25 identity in 123 aa overlap. Contains Pfam match to entry pro_isomerase PF00160%2C Peptidyl-prolyl cis-trans isomerases%2C score 77.82 gene gene6002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5939 SCO5940 SCO5940 SC7H1.10 SC7H1.10 6507329 6507988 + hypothetical protein SC7H1.10%2C probable transferase%2C len: 219 aa%3B similar to eg. MENG_ECOLI P32165 s-adenosylmethionine:2-demethylmenaquinone methyltransferase (161 aa)%2C fasta scores%3B opt: 211 z-score: 265.9 E(): 1.3e-07%2C 34.1%25 identity in 126 aa overlap gene gene6003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5940 SCO5941 SCO5941 SC7H1.11 SC7H1.11 6507985 6509133 + aminotransferase SC7H1.11%2C probable aminotransferase%2C len: 382%3B similar to many eg. AAT_BACST Q59228 aspartate aminotransferase (ec 2.6.1.1 (393 aa)%2C fasta scores%3B opt: 683 z-score: 686.1 E(): 5.1e-31%2C 35.0%25 identity in 374 aa overlap. Contains Pfam match to entry aminotran_1 PF00155%2C Aminotransferases class-I%2C score 177.68 gene gene6004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5941 SCO5942 SCO5942 SC7H1.12 SC7H1.12 6509216 6509833 + hypothetical protein SC7H1.12%2C unknown%2C len: 205 aa%3B very weak similarity to downstream ORF SC7H1.21 (203 aa)%2C (E(): 0.085%2C 26.9%25 identity in 208 aa overlap). Contains possible Helix-turn-helix motif at aa 41-62%2C Score 1089 (+2.90 SD) gene gene6005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5942 SCO5943 SCO5943 SC7H1.13 SC7H1.13 6510025 6510810 + hydrolase SC7H1.13%2C probable hydrolase%2C len: 261%3B weak similarity to several diverse hydrolases eg. TODF_PSEPU P23133 2-hydroxy-6-oxo-2%2C4-heptadienoate hydrolase (276 aa)%2C fasta scores%3B opt: 196 z-score: 344.3 E(): 5.5e-12%2C 30.7%25 identity in 270 aa overlap gene gene6006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5943 SCO5944 SCO5944 SC7H1.14 SC7H1.14 6510803 6511951 + hypothetical protein SC7H1.14%2C unknown%2C len: 382 aa gene gene6007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5944 SCO5945 SCO5945 SC7H1.15 SC7H1.15 6511948 6513768 + transferase SC7H1.15%2C probable transferase%2C len: 606 aa%3B similar to TR:Q54353 (EMBL:X64651) S.lincolnensis lmbA gene for lincomycin condensing protein (601 aa)%2C fasta scores%3B opt: 921 z-score: 1470.0 E(): 0%2C 45.8%25 identity in 600 aa overlap and to other gamma-glutamyl transferases gene gene6008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5945 SCO5946 SCO5946 SC7H1.16 SC7H1.16 6513765 6514538 + hypothetical protein SC7H1.16%2C membrane protein%2C Gly-%2C Ala-rich protein%2C len: 257 aa. Contains possible hydrophobic membrane spanning regions gene gene6009 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5946 SCO5947 SCO5947 SC7H1.17 SC7H1.17 6514553 6515950 + hypothetical protein SC7H1.17%2C probable integral membrane protein%2C len: 465 aa%3B weakly similar to many eg. Mycobacterium tuberculosis TR:O07753 (EMBL:Z97193) MTCY180.41C (687 aa)%2C fasta scores%3B opt: 440 z-score: 332.4 E(): 2.5e-11%2C 26.6%25 identity in 413 aa overlap. Contains possible hydrophobc membrane spanning regions gene gene6010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5947 SCO5948 SCO5948 SC7H1.18 SC7H1.18 6515947 6517140 + oxidoreductase SC7H1.18%2C possible oxidoreductase%2C len: 397 aa%3B weak similarity to TCMG_STRGA P39888 tetracenomycin polyketide synthesis hydroxylase (572 aa)%2C fasta scores%3B opt: 72 z-score: 275.1 E(): 4e-08%2C 26.0%25 identity in 369 aa overlap. Also similar to M. tuberculosis hypothetical protein Y08M_MYCTU Q11058 MTCY50.22c (372 aa)%2C fasta scores%3B opt: 949 z-score: 613.3 E(): 5.8e-27%2C 45.9%25 identity in 355 aa overlap gene gene6011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5948 SCO5949 SCO5949 SC7H1.19 SC7H1.19 6517425 6517973 + hypothetical protein SC7H1.19%2C unknown%2C len: 182 aa gene gene6012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5949 SCO5950 SCO5950 SC7H1.20c SC7H1.20c 6518093 6519544 - export protein SC7H1.20c. probable export protein%2C len: 483%3B similar to many members of the drug resistance translocase family eg. Streptomyces lipmanii PUR8_STRLP P42670 puromycin resistance protein pur8 (503 aa)%2C fasta scores%3B opt: 907 z-score: 636.6 E(): 2.9e-28%2C 38.6%25 identity in 477 aa overlap. Also weakly similar to upstream protein SC7H1.27 (533 aa) (E(): 7.9e-15%2C 28.6%25 identity in 461 aa overlap) gene gene6013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5950 SCO5951 SCO5951 SC7H1.21 SC7H1.21 6519692 6520303 + transcriptional regulator SC7H1.21%2C probable transcriptional regulator%2C len: 203 aa%3B similar to many eg. Streptomyces hygroscopicus TR:Q54288 (EMBL:X86780) regulator of antibiotic transport complexes (204 aa)%2C fasta scores%3B opt: 263 z-score: 351.4 E(): 2.2e-12%2C 33.7%25 identity in 196 aa overlap. Contains probable Helix-turn-helix motif at aa 41-61%2C Score 1399 (+3.95 SD) and Pfam match to entry tetR PF00440%2C Bacterial regulatory proteins%2C tetR family%2C score 23.60 gene gene6014 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5951 SCO5952 SCO5952 SC7H1.22 SC7H1.22 6520547 6521299 + hypothetical protein SC7H1.22%2C membrane protein%2C len: 250 aa. Contains possible hydrophobic membrane spanning regions gene gene6015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5952 SCO5953 SCO5953 SC7H1.23 SC7H1.23 6521302 6524043 + hypothetical protein SC7H1.23%2C membrane protein%2C len: 913 aa%3B weakly similar to many members of the eukaryotic beta-transducin family e.g. YA3A_SCHPO Q09715 hypothetical Trp-Asp repeats containing protein (614 aa)%2C fasta scores%3B opt: 139 z-score: 352.6 E(): 1.9e-12%2C 28.8%25 identity in 250 aa overlap. Contains possible membrane spanning domain around aa 200 and 3x Pfam match to entry G-beta PF00400%2C WD domain%2C G-beta repeats%2C scores%3B 27.34%2C 28.55 and 25.74 gene gene6016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5953 SCO5954 SCO5954 SC7H1.24 SC7H1.24 6524142 6526439 + chitinase SC7H1.24%2C probable chitinase (hypothetical protein)%2C len: 765 aa%3B similar to many eg. S. lividans CHIT_STRLI P36909 chitinase c precursor (ec 3.2.1.14) (619 aa)%2C fasta scores%3B opt: 292 z-score: 779.5 E(): 0%2C 35.1%25 identity in 752 aa overlap. Contains PS01095 Chitinases family 18 active site signature%2C and possible N-terminal region signal peptide sequence gene gene6017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5954 SCO5955 SCO5955 SC7H1.25c SC7H1.25c 6526506 6526940 - hypothetical protein SC7H1.25c%2C membrane protein%2C len: 144 aa%3B similar to Mycobacterium tuberculosis hypothetical protein O06193 (EMBL:Z95387) MTCY1A10.13 (141 aa)%2C fasta scores%3B opt: 459 z-score: 576.2 E(): 6.7e-25%2C 56.4%25 identity in 140 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5955 SCO5956 SCO5956 SC7H1.26 SC7H1.26 6526903 6527715 + regulatory protein SC7H1.26%2C possible regulatory protein%2C len: 270 aa%3B contains probable Helix-turn-helix motif at aa 91-112%2C Score 1562 (+4.51 SD) and Pfam match to entry tetR PF00440%2C Bacterial regulatory proteins%2C tetR family gene gene6019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5956 SCO5957 SCO5957 SC7H1.27 SC7H1.27 6527871 6529472 + transporter SC7H1.27%2C probable transmembrane transport protein%2C len: 533 aa%3B similar to many eg. S. pristinaespiralis TR:Q54806 (EMBL:X84072) integral membrane protein (501 aa)%2C fasta scores%3B opt: 1088 z-score: 1144.1 E(): 0%2C 39.5%25 identity in 524 aa overlap. Also weakly similar to upstream ORF SC7H1.20c (E(): 4.2e-12%2C 28.6%25 identity in 461 aa overlap) gene gene6020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5957 SCO5958 SCO5958 cbiO cbiO 6529489 6530343 - cobalt transport system ATP binding protein SC7H1.28c%2C cbiO%2C probable cobalt transport system ATP binding protein%2C len: 284 aa%3B similar to many eg. CBIO_SALTY Q05596 cobalt transport ATP-binding protein (271 aa)%2C fasta scores%3B opt: 567 z-score: 685.3 E(): 5.6e-31%2C 38.8%25 identity in 242 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry ABC_tran PF00005%2C ABC transporters%2C score 203.07 gene gene6021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5958 SCO5959 SCO5959 cbiQ cbiQ 6530340 6531089 - cobalt transport integral membrane protein SC7H1.29c%2C cbiQ%2C probable cobalt transport integral membrane protein%2C len: 249 aa%3B similar to eg. CBIQ_SALTY Q05598 cobalt transport protein cbiq (225 aa)%2C fasta scores%3B opt: 182 z-score: 241.4 E(): 3e-06%2C 28.1%25 identity in 228 aa overlap gene gene6022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5959 SCO5960 SCO5960 cbiN cbiN 6531090 6531446 - cobalt transport protein CbiN periplasmic cobalt binding component of the cobalt transport system gene gene6023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5960 SCO5961 SCO5961 cbiM cbiM 6531443 6532141 - cobalt transport protein CbiM catalyzes the ATP-dependent transport of cobalt gene gene6024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5961 SCO5962 SCO5962 SC7H1.32c SC7H1.32c 6532428 6533018 - transcriptional regulator SC7H1.32c%2C probable transcriptional regulator%2C MerR family%3B len: 196 aa%3B similar to many eg. NOLA_BRASN P50330 nodulation protein nola. bradyrhizobium japonicum (237 aa)%2C fasta scores%3B opt: 282 z-score: 360.0 E(): 7.4e-13%2C 34.6%25 identity in 159 aa overlap. Contains PS00552 Bacterial regulatory proteins%2C merR family signature%2C Helix-turn-helix motif at aa 10-31%2C Score 1627 (+4.73 SD)%2C and Pfam match to entry merR PF00376%2C Bacterial regulatory proteins%2C merR family%2C score 92.85 gene gene6025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5962 SCO5963 SCO5963 SC7H1.33c SC7H1.33c 6533083 6533658 - hypothetical protein SC7H1.33c%2C possible membrane protein%2C len: 191%3B Contains PS00044 Bacterial regulatory proteins%2C lysR family signature%2C though this may be spurious gene gene6026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5963 SCO5964 SCO5964 SC7H1.34c SC7H1.34c 6533655 6535013 - hypothetical protein SC7H1.34c%2C probable membrane protein%2C len: 452 aa%3B contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Contains possible hydrophobic membrane spanning regions gene gene6027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5964 SCO5965 SCO5965 SC7H1.35 SC7H1.35 6535301 6535768 + hypothetical protein SC7H1.35%2C possible integral membrane protein%2C len: 155 aa%3B weakly similar to hypothetival proteins from Archaeoglobus fulgidus and Mycobacterium leprae e.g. TR:G2650576 (EMBL:AE001101) AF0081 hypothetical 17.4 kd protein from Archaeoglobus fulgidus (156 aa)%2C fasta scores%3B opt: 129 z-score: 186.3 E(): 0.0035%2C 28.7%25 identity in 101 aa overlap and similar to TR:O86494 (EMBL:AL031232) Streptomyces coelicolor integral membrane protein SC10H5.02c%2C 151 aa%3B fasta scores: opt: 431 Z-score: 491.5 E(): 9.6e-20%3B 53.509%25 identity in 114 aa overlap. Contains possible hydrophobic membrane spannig regions gene gene6028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5965 SCO5966 SCO5966 SC7H1.36c SC7H1.36c 6535912 6539055 - oxidase SCBAC16H6.01c%2C possible oxidase%2C len: >1032aa: similar to many of undefined function eg. TR:Q9EZK2 (EMBL:AF289509) oxidase YdiJ-like protein from Pseudomonas putida (1006 aa) fasta scores%3B opt: 880%2C Z-score: 889.5%2C 27.930%25 identity (31.672%25 ungapped) in 1024 aa overlap and TR:Q9F2Y0 (EMBL:AL392149) oxidoreductase SCD19.22 from Streptomyces coelicolor (951 aa) fasta scores%3B opt: 622%2C Z-score: 628.7%2C 49.698%25 identity (53.813%25 ungapped) in 994 aa overlap. Contains Prosite match to PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature%3B Pfam match to entry PF02913 FAD-oxidase_C%2C FAD linked oxidases%2C C-terminal domain and Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain.~SC7H1.36c%2C unknown%2C partial CDS%2C len: >81 aa gene gene6029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5966 SCO5967 SCO5967 SCBAC16H6.02 SCBAC16H6.02 6539260 6539670 + hypothetical protein SCBAC16H6.02%2C conserved hypothetical protein%2C len: 136aa: similar to many eg. TR:Q9EWX7 (EMBL:AL445403) conserved hypothetical protein 2SCI34.02 from Streptomyces coelicolor (146 aa) fasta scores%3B opt: 257%2C Z-score: 325.1%2C 41.667%25 identity (43.269%25 ungapped) in 108 aa overlap. gene gene6030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5967 SCO5968 SCO5968 StBAC16H6.03 StBAC16H6.03 6539766 6540974 + bldA-regulated nucleotide binding protein SCBAC16H6.03%2C possible bldA-regulated nucleotide binding protein%2C len: 402aa: no significant database matches. Contains TTA-encoded leucine close to N-terminus - possible target for bldA regulation. Also contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5968 SCO5969 SCO5969 StBAC16H6.04 StBAC16H6.04 6540971 6541324 + hypothetical protein SCBAC16H6.04%2C conserved hypothetical protein%2C len: 402aa: similar to many eg. TR:Q9K5U1 (EMBL:AP001520) BH3997 protein from Bacillus halodurans (101 aa) fasta scores%3B opt: 282%2C Z-score: 358.7%2C 40.196%25 identity (42.268%25 ungapped) in 102 aa overlap. gene gene6032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5969 SCO5970 SCO5970 StBAC16H6.05 StBAC16H6.05 6541507 6541977 + hypothetical protein SCBAC16H6.05%2C unknown%2C len: 156 aa: no significant database matches. Contains TTA-encoded leucine close to C-terminus. gene gene6033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5970 SCO5971 SCO5971 StBAC16H6.06 StBAC16H6.06 6542306 6543229 + hypothetical protein SCBAC16H6.06%2C conserved hypothetical protein%2C len: 307 aa: similar to many e.g. TR:AAK45058 (EMBL:AE006971) hypothetical protein from Mycobacterium tuberculosis (347 aa) fasta scores%3B opt: 482%2C Z-score: 543.4%2C 32.399%25 identity (37.011%25 ungapped) in 321 aa overlap. Contains Pfam match to entry PF00296 bac_luciferase%2C Bacterial luciferase gene gene6034 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5971 SCO5972 SCO5972 StBAC16H6.07 StBAC16H6.07 6543305 6544900 + 3' terminal RNA ribose 2'-O-methyltransferase Hen1 SCBAC16H6.07%2C hypothetical protein with conserved region%2C len: 307aa: 300-500 aa region similar to many eg. TR:Q9V662 (EMBL:AE003823) CG12367 protein from Drosophila melanogaster (309 aa) fasta scores%3B opt: 294%2C Z-score: 338.2%2C 34.194%25 identity (37.324%25 ungapped) in 155 aa overlap. gene gene6035 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5972 SCO5973 SCO5973 StBAC16H6.08 StBAC16H6.08 6544981 6547509 + phosphatase SCBAC16H6.08%2C possible phosphatase%2C len: 842 aa: similar to TR:O69213 (EMBL:AJ224354) protein serine-threonine phosphatase from Anabaena sp. (strain PCC 7120) fasta scores%3B opt: 2173%2C Z-score: 2321.6%2C 52.962%25 identity (54.808%25 ungapped) in 861 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6036 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5973 SCO5974 SCO5974 StBAC16H6.09c StBAC16H6.09c 6547561 6548856 - integral membrane ion exchanger SCBAC16H6.09c%2C possible integral membrane ion exchanger%2C len: 431 aa: similar to many eg. TR:Q9LUN4 (EMBL:AB022219) Na+/H+ exchanging protein-like from Arabidopsis thaliana (800 aa) fasta scores%3B opt: 667%2C Z-score: 684.9%2C 34.048%25 identity (35.572%25 ungapped) in 420 aa overlap. Contains Pfam match to entry PF00999 Na_H_Exchanger%2C Sodium/hydrogen exchanger family and multiple possible membrane-spanning hydrophobic regions. gene gene6037 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5974 SCO5975 SCO5975 arcA2 arcA2 6549048 6550304 + arginine deiminase SCBAC16H6.10%2C arcA2%2C arginine deiminase%2C len: 418 aa: similar to many e.g. SW:Q9RJN1 (ARCA_STRCO) arginine deaminase ArcA SCF55.37 from Streptomyces coelicolor (420 aa) fasta scores%3B opt: 1124%2C Z-score: 1310.8%2C 43.350%25 identity (43.781%25 ungapped) in 406 aa overlap and SW:O31017 (ARCA_RHIET) arginine deaminase from Rhizobium etli (409 aa) fasta scores%3B opt: 1153%2C Z-score: 1344.7%2C 45.854%25 identity (47.000%25 ungapped) in 410 aa overlap. Contains Pfam match to entry PF02726 Arg_deiminase%2C Arginine deiminase. gene gene6038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5975 SCO5976 SCO5976 arcB arcB 6550399 6551406 + ornithine carbamoyltransferase catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway gene gene6039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5976 SCO5977 SCO5977 StBAC16H6.12 StBAC16H6.12 6551536 6552975 + amino acid permease SCBAC16H6.12%2C possible amino acid permease%2C len: 479aa: similar to many eg. SW:O43246 (CTR4_HUMAN) cationic amino acid permease from Homo sapiens (636 aa) fasta scores%3B opt: 704%2C Z-score: 760.9%2C 33.679%25 identity (34.946%25 ungapped) in 386 aa overlap and TR:Q9L100 (EMBL:AL159139) amino acid permease SCL6.16c from Streptomyces coelicolor (496 aa) fasta scores%3B opt: 1575%2C Z-score: 1699.3%2C 53.377%25 identity (53.493%25 ungapped) in 459 aa overlap. Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and possible membrane-spanning hydrophobic regions. gene gene6040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5977 SCO5978 SCO5978 StBAC16H6.13c StBAC16H6.13c 6552935 6553420 - hypothetical protein SCBAC16H6.13c%2C conserved hypothetical protein%2C len: 161aa: similar to many others in Streptomyces coelicolor eg. TR:Q9X7Q5 (EMBL:AL049587) hypothetical protein SC5F2A.32 (161 aa) fasta scores%3B opt: 222%2C Z-score: 255.7%2C 32.515%25 identity (36.054%25 ungapped) in 163 aa overlap. Also similar to TR:O69204 (EMBL:U33059) hypothetical protein from Actinosynnema pretiosum (subsp. auranticum) (144 aa) fasta scores%3B opt: 227%2C Z-score: 261.8%2C 39.735%25 identity (45.113%25 ungapped) in 151 aa overlap. Contains Pfam match to entry PF02518 HATPase_c%2C Histidine kinase-%2C DNA gyrase B-%2C phytochrome-like ATPase. gene gene6041 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5978 SCO5979 SCO5979 StBAC16H6.14 StBAC16H6.14 6553552 6554379 + enoyl-CoA hydratase Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA gene gene6042 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5979 SCO5980 SCO5980 StBAC16H6.15 StBAC16H6.15 6554384 6556789 + salicylyl-CoA 5-hydroxylase catalyzes the conversion of salicylyl-CoA to gentisyl-CoA gene gene6043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5980 SCO5981 SCO5981 StBAC16H6.16c StBAC16H6.16c 6556777 6557688 - hypothetical protein SCBAC16H6.16c%2C unknown%2C len: 303 aa: contains weak Pfam match to entry PF00685 Sulfotransfer%2C Sulfotransferases gene gene6044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5981 SCO5982 SCO5982 StBAC16H6.17c StBAC16H6.17c 6557772 6558617 - regulator SCBAC16H6.17c%2C possible regulator%2C len: 281 aa: weakly similar to SW:P76086 (PAAX_ECOLI) phenylacetic acid degradation repressor protein from Escherichia coli (316 aa) fasta scores%3B opt: 266%2C Z-score: 305.3%2C 26.071%25 identity (28.077%25 ungapped) in 280 aa overlap. gene gene6045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5982 SCO5983 SCO5983 StBAC16H6.18c StBAC16H6.18c 6558619 6560310 - fatty acid-CoA ligase SCBAC16H6.18c%2C possible fatty acid-CoA ligase%2C len: 563 aa: similar to many e.g. TR:Q53005 (EMBL:U02033) 4-hydroxybenzoate-coenzyme A ligase rom Rhodopseudomonas palustris (539 aa) fasta scores%3B opt: 758%2C Z-score: 808.8%2C 33.747%25 identity (35.667%25 ungapped) in 483 aa overlap and TR:BAB48174 (EMBL:AP002995) probable acid-CoA ligase from Rhizobium loti (541 aa) fasta scores%3B opt: 1793%2C Z-score: 1909.7%2C 51.866%25 identity (53.565%25 ungapped) in 536 aa overlap. Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and Prosite match to PS00455 AMP-binding domain signature. gene gene6046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5983 SCO5984 SCO5984 StBAC16H6.19 StBAC16H6.19 6560442 6561617 + acyl-CoA dehydrogenase SCBAC16H6.19%2C possible acyl-CoA dehydrogenase%2C len: 391aa: similar to many eg. SW:P16219 (ACDS_HUMAN) acyl-CoA dehydrogenase from Homo sapiens (412 aa) fasta scores%3B opt: 676%2C Z-score: 741.3%2C 35.121%25 identity (37.006%25 ungapped) in 373 aa overlap and SW:P96879 (ACDP_MYCTU) probable acyl-CoA dehydrogenase from Mycobacterium tuberculosis (389 aa) fasta scores%3B opt: 735%2C Z-score: 805.9%2C 35.676%25 identity (37.394%25 ungapped) in 370 aa overlap. Contains Pfam match to entry PF02770 Acyl-CoA_dh_M%2C Acyl-CoA dehydrogenase%2C middle domain%3B Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase%2C C-terminal domain and Prosite match to PS00072 Acyl-CoA dehydrogenases signature 1. gene gene6047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5984 SCO5985 SCO5985 StBAC16H6.20 StBAC16H6.20 6561614 6562012 + hypothetical protein SCBAC16H6.20%2C conserved hypothetical protein%2C len: 132aa: similar to many eg. TR:BAB51882 (EMBL:AP003006) MLL5429 protein from Rhizobium loti (137 aa) fasta scores%3B opt: 271%2C Z-score: 331.4%2C 34.884%25 identity (35.156%25 ungapped) in 129 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C YjgF family. gene gene6048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5985 SCO5986 SCO5986 StBAC16H6.21 StBAC16H6.21 6562040 6562867 + oxidoreductase SCBAC16H6.21%2C possible oxidoreductase%2C len: 275aa: similar to many eg. TR:O53622 (EMBL:AL021428) oxidoreductase from Mycobacterium tuberculosis (276 aa) fasta scores%3B opt: 521%2C Z-score: 601.4%2C 36.364%25 identity (38.314%25 ungapped) in 275 aa overlap and TR:Q53042 (EMBL:AF060871) haloalkane dehalogenase from Rhodococcus rhodochrous (293 aa) fasta scores%3B opt: 249%2C Z-score: 291.2%2C 28.417%25 identity (31.102%25 ungapped) in 278 aa overlap. gene gene6049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5986 SCO5987 SCO5987 StBAC16H6.21c StBAC16H6.21c 6562884 6563093 - hypothetical protein SCBAC16H6.21c%2C conserved hypothetical protein%2C len: 69aa: similar to two others in Streptomyces coelicolor - TR:Q9AK87 (EMBL:AL583943) SC10A9.17 (chromosomal) (67 aa) fasta scores%3B opt: 276%2C Z-score: 372.9%2C 60.317%25 identity (63.333%25 ungapped) in 63 aa overlap and TR:Q9AD54 (EMBL:AL590463) SCP1.96 (plasmid) (79 aa) fasta scores%3B opt: 274%2C Z-score: 369.2%2C 59.322%25 identity (61.404%25 ungapped) in 59 aa overlap. gene gene6050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5987 SCO5988 SCO5988 StBAC16H6.23 StBAC16H6.23 6563335 6563778 + hypothetical protein SCBAC16H6.23%2C conserved hypothetical protein%2C len: 147aa: weakly similar to others eg. TR:Q9RSG5 (EMBL:AE002049) hypothetical protein from Deinococcus radiodurans (255 aa) fasta scores%3B opt: 118%2C Z-score: 140.3%2C 28.873%25 identity (32.540%25 ungapped) in 142 aa overlap. gene gene6051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5988 SCO5989 SCO5989 StBAC16H6.24c StBAC16H6.24c 6563897 6564781 - hypothetical protein SCBAC16H6.24c%2C possible integral membrane protein%2C len: 294aa: similar to TR:Q9K400 (EMBL:AL359949) integral membrane protein 2SCG61.15 from Streptomyces coelicolor (322 aa) fasta scores%3B opt: 900%2C Z-score: 931.3%2C 52.597%25 identity (59.124%25 ungapped) in 308 aa overlap. Contains possible membrane-spanning hydrophobic regions gene gene6052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5989 SCO5990 SCO5990 StBAC16H6.25c StBAC16H6.25c 6564792 6565028 - hypothetical protein SCBAC16H6.25c%2C unknown%2C len: 78 aa: no significant database matches. gene gene6053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5990 SCO5991 SCO5991 StBAC16H6.26 StBAC16H6.26 6565263 6565649 + hypothetical protein SCBAC16H6.26%2C possible hypothetical protein%2C len: 128aa: no significant database matches. Contains a possible N-terminal signal sequence. gene gene6054 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5991 SCO5992 SCO5992 StBAC16H6.27 StBAC16H6.27 6565701 6566195 + hypothetical protein SCBAC16H6.27%2C possible integral membrane protein%2C len: 164aa: no significant database matches. Contains possible membrane-spanning hydrophobic regions. gene gene6055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5992 SCO5993 SCO5993 StBAC16H6.28 StBAC16H6.28 6566262 6567074 + hypothetical protein SCBAC16H6.28%2C possible membrane protein%2C len: 270aa: weakly similar to TR:BAB53967 (EMBL:AP003012) MLR7525 protein from Rhizobium loti (250 aa) fasta scores%3B opt: 340%2C Z-score: 379.4%2C 28.400%25 identity (30.603%25 ungapped) in 250 aa overlap. Contains a possible membrane-spanning hydrophobic region gene gene6056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5993 SCO5994 SCO5994 StBAC16H6.29 StBAC16H6.29 6567071 6567973 + integral membrane cytochrome biogenesis protein SCBAC16H6.29%2C possible integral membrane cytochrome biogenesis protein%2C len: 300 aa%3B similar to TR:Q9R6T1 (EMBL:AF079137) CcdA from Synechococcus sp. (strain PCC 6301) (252 aa) fasta scores%3B opt: 245%2C Z-score: 273.8%2C 30.208%25 identity (33.721%25 ungapped) in 192 aa overlap. Contains Pfam match to entry PF02683 DsbD%2C Cytochrome C biogenesis protein transmembrane region and possible membrane-spanning hydrophobic regions gene gene6057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5994 SCO5995 SCO5995 StBAC16H6.30 StBAC16H6.30 6568057 6568779 + hypothetical protein SCBAC16H6.30%2C possible hypothetical protein%2C len: 240aa: similar to TR:Q9KYR3 (EMBL:AL355913) lipoprotein SC5H4.26c from Streptomyces coelicolor (187 aa) fasta scores%3B opt: 133%2C Z-score: 148.7%2C 31.783%25 identity (36.607%25 ungapped) in 129 aa overlap. Contains a possible N-terminal signal sequence. Also contains TTA leucine codon. Possible target for bldA regulation. gene gene6058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5995 SCO5996 SCO5996 StBAC16H6.31 StBAC16H6.31 6568779 6571592 + hypothetical protein SCBAC16H6.31%2C possible membrane protein%2C len: 937 aa: similar to TR:O54182 (EMBL:AL021411) hypothetical protein SC7H1.23 from Streptomyces coelicolor (913 aa) fasta scores%3B opt: 1128%2C Z-score: 1138.9%2C 29.418%25 identity (31.524%25 ungapped) in 928 aa overlap. C-terminal region contains 13 Pfam matches to entry PF00400 WD40%2C WD domain%2C G-beta repeat%3B 5 Prosite matches to PS00678 Trp-Asp (WD) repeats signature and a Prosite match to PS00626 Regulator of chromosome condensation (RCC1) signature 2 gene gene6059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5996 SCO5997 SCO5997 StBAC16H6.32 StBAC16H6.32 6572032 6572550 + hypothetical protein SCBAC16H6.32%2C possible hypothetical protein%2C len: 172aa: similar to others from Streptomyces coelicolor eg. TR:Q9AJX2 (EMBL:AL513407) hypothetical protein SCI33.04 (244 aa) fasta scores%3B opt: 622%2C Z-score: 669.7%2C 61.111%25 identity (62.658%25 ungapped) in 162 aa overlap. Contains a possible N-terminal signal sequence gene gene6060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5997 SCO5998 SCO5998 murA2 murA2 6573186 6574715 - UDP-N-acetylglucosamine transferase SCBAC1C11.01c%2C murA2%2C possible bifunctional protein (fragment)%2C len: >138 aa%3B N-terminal domain similar to TR:Q9X153 (EMBL:AE001787) Thermotoga maritima lacI-family transcriptional regulator%2C TM1330%2C 111 aa%3B fasta scores: opt: 139 z-score: 193.0 E(): 0.0033%3B 39.4%25 identity in 66 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and possible helix-turn-helix motif at residues 22..43 (+7.45 SD) and C-terminal domain similar to TR:Q9PJT7 (EMBL:AE002342) Chlamydia muridarum UDP-N-acetylglucosamine 1-carboxyvinyltransferase TC0740%2C 442 aa%3B fasta scores: opt: 148 z-score: 195.2 E(): 0.0025%3B 38.1%25 identity in 63 aa overlap~SCBAC16H6.33c%2C murA2%2C possible UDP-N-acetylglucosamine transferase%2C len: 437 aa: similar to many eg. SW:P33986 (MURA_ACIGB) UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter genomosp. 11 (419 aa) fasta scores%3B opt: 438%2C Z-score: 509.1%2C 30.233%25 identity (31.863%25 ungapped) in 430 aa overlap and TR:Q9L1U5 (EMBL:AL138851) UDP-N-acetylglucosamine transferase from Streptomyces coelicolor SCE59.08 (448 aa) fasta scores%3B opt: 484%2C Z-score: 561.7%2C 29.890%25 identity (33.252%25 ungapped) in 455 aa overlap. Contains Pfam match to entry PF00275 EPSP_syntase%2C EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). gene gene6061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5998 SCO5999 SCO5999 sacA sacA 6575305 6578019 + aconitate hydratase Catalyzes the conversion of citrate to isocitrate gene gene6062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO5999 SCO6000 SCO6000 SCBAC1C11.03 SCBAC1C11.03 6578236 6578481 + hypothetical protein SCBAC1C11.03%2C hypothetical protein%2C len: 81 aa%3B low similarity to TR:Q9RDI8 (EMBL:AL136519) Streptomyces coelicolor hypothetical 7.0 kDa protein SCC57A.09c%2C 65 aa%3B fasta scores: opt: 135 z-score: 199.2 E(): 0.0015%3B 46.2%25 identity in 52 aa overlap gene gene6063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6000 SCO6001 SCO6001 SCBAC1C11.04 SCBAC1C11.04 6578520 6578807 + hypothetical protein SCBAC1C11.04%2C membrane protein%2C len: 95 aa. Contains possible hydrophobic membrane spanning region gene gene6064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6001 SCO6002 SCO6002 SCBAC1C11.05c SCBAC1C11.05c 6578743 6579171 - hypothetical protein SCBAC1C11.05c%2C membrane protein%2C len: 142 aa. Contains possible hydrophobic membrane spanning regions gene gene6065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6002 SCO6003 SCO6003 SCBAC1C11.06c SCBAC1C11.06c 6579213 6580073 - DNA-binding protein SCBAC1C11.06c%2C possible DNA-binding protein%2C len: 286 aa%3B similar to TR:CAC01466 (EMBL:AL391014) Streptomyces coelicolor DNA-binding protein 2SCG1.17%2C 286 aa%3B fasta scores: opt: 528 z-score: 639.9 E(): 4.2e-28%3B 37.4%25 identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and possible helix-turn-helix motif at residues 27..48 (+4.04 SD) gene gene6066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6003 SCO6004 SCO6004 SC7B7.01c SC7B7.01c 6580256 6584062 - ATP/GTP binding protein SC7B7.01c%2C ATP/GTP binding protein%2C partial ORF%2C len: >626 aa%3B contains possible N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop)~SCBAC1C11.07c%2C conserved hypothetical protein (fragment)%2C len: >676 aa%3B similar to C-terminal domain of TR:Q9WXI8 (EMBL:AB025248) Bacillus sp. M-90 alpha-1%2C2-mannosidase precursor AmaN2%2C 1976 aa%3B fasta scores: opt: 1575 z-score: 1715.3 E(): 0%3B 45.7%25 identity in 705 aa overlap gene gene6067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6004 SCO6005 SCO6005 SC7B7.02 SC7B7.02 6584624 6586033 + lipoprotein SC7B7.02%2C possible lipoprotein%2C len: 469%3B has similarity to signal sequence of Mycobacterium leprae hypothetical protein TR:E334742 (EMBL:Z98604) MLCB2052.27 (445 aa)%2C fasta scores%3B opt: 75 z-score: 199.2 E(): 0.00062%2C 23.3%25 identity in 335 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6005 SCO6006 SCO6006 SC7b7.03 SC7b7.03 6586041 6587102 + transmembrane transport protein SC7b7.03%2C probable integral membrane transport protein%2C len: 353 aa%3B similar to many members of the MALFG subfamily of the binding-protein-dependant transport system membrane proteins eg. MSMF_STRMU Q00750 multiple sugar-binding transport system permease (290 aa)%2C fasta scores%3B opt: 393 z-score: 636.8 E(): 2.6e-28%2C 32.5%25 identity in 280 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature gene gene6069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6006 SCO6007 SCO6007 SC7b7.04 SC7b7.04 6587099 6588007 + transmembrane transport protein SC7b7.04%2C probable integral membrane transport protein%2C len: 301 aa%3B similar to many members of the MALFG subfamily of the binding-protein-dependant transport systems membrane proteins eg. TR:Q06111 (EMBL:X66092) transport system permease from Clostridium perfringens (275 aa)%2C fasta scores%3B opt: 590 z-score: 796.5 E(): 0%2C 33.6%25 identity in 265 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature gene gene6070 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6007 SCO6008 SCO6008 SC7B7.05 SC7B7.05 6588242 6589453 + transcriptional repressor protein SC7B7.05%2C probable transcriptional repressor protein%2C len 403 aa%3B similar to many eg. XYLR_ANATH Q44406 xylose repressor from Anaerocellum thermophilum (399 aa)%2C fasta scores%3B opt: 548 z-score: 767.3 E(): 0%2C 33.1%25 identity in 393 aa overlap. Contains PS01125 ROK family signature and helix-turn-helix motif at aa positions 29-50 (Score 2016%2C +6.05 SD) gene gene6071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6008 SCO6009 SCO6009 SC7B7.06 SC7B7.06 6589575 6590690 + solute-binding protein SC7B7.06%2C probable solute-binding protein of transmembrane transport system%2C len: 403 aa%3B similar to many eg. XYLF_ECOLI P37387 d-xylose-binding periplasmic protein precursor (330 aa)%2C fasta scores%3B opt: 619 z-score: 573.4 E(): 8.9e-25%2C 35.7%25 identity in 325 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6009 SCO6010 SCO6010 SC7B7.07 SC7B7.07 6590859 6591641 + ABC transporter ATP-binding protein SC7B7.07%2C probable ABC-transport system ATP binding protein%2C len: 260 aa%3B similar to many eg. XYLG_ECOLI P37388 d-xylose transport atp-binding protein (513 aa)%2C fasta scores%3B opt: 567 z-score: 580.0 E(): 3.8e-25%2C 36.5%25 identity in 255 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Possible alternative start 9 bp upstream. gene gene6073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6010 SCO6011 SCO6011 SC7B7.08 SC7B7.08 6591638 6592930 + ABC transporter SC7B7.08%2C probable ABC-type trans- membrane transport protein%2C len: 430 aa%3B similar to many others of the ARAH/RBSC subfamily of the binding-protein dependent transport systems eg. XYLH_ECOLI P37389 xylose transport permease xylH (393 aa)%2C fasta scores%3B opt: 695 z-score: 690.3 E(): 2.7e-31%2C 34.2%25 identity in 377 aa overlap. Possible alternative start site 33 aa downstream gene gene6074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6011 SCO6012 SCO6012 SC7B7.09c SC7B7.09c 6593034 6594557 - chitinase SC7B7.09c%2C probable hydrolase (hypothetical protein)%2C len: 507 aa%3B similar to many chitinases eg. TR:Q59145 (EMBL:D31818) chitinase II precursor (EC 3.2.1.14) Aeromonas sp. (542 aa)%2C fasta scores%3B opt: 410 z-score: 512.7 E(): 2.1e-21%2C 32.1%25 identity in 498 aa overlap. Contains N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene6075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6012 SCO6013 SCO6013 SC1C3.01 SC1C3.01 6594926 6596854 + 1-deoxy-D-xylulose-5-phosphate synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate gene gene6076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6013 SCO6014 SCO6014 SC1C3.02 SC1C3.02 6597042 6598553 + cationic amino acid transporter SC1C3.02%2C possible cationic amino acid transporter%2C len: 503 aa%3B similar to many bacterial membrane proteins e.g. M. tuberculosis TR:O05896 EMBL%3B Z95121 MTCY20B11.28c (495 aa)%2C fasta scores%3B opt: 1649 z-score: 2116.1 E(): 0%2C 52.6%25 identity in 485 aa overlap%2C and to many eukaryotic transporters e.g. CTR1_HUMAN high-affinity cationic amino acid transporter (629 aa)%2C fasta scores%3B opt: 897 z-score: 1337.3E(): 0%2C 35.0%25 identity in 432 aa overlap. Contains 2x Pfam match to entry aa_permeases PF00324%2C Amino acid permeases%2C scores 50.38 and 51.60 gene gene6077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6014 SCO6015 SCO6015 SC1C3.03c SC1C3.03c 6598656 6599033 - hypothetical protein SC1C3.03c%2C unknown%2C len: 125 aa%3B some similarity to a hypothetical protein from M. tuberculosis TR:E1256517 (EMBL:AL022073) MTV051.14 (135 aa)%2C fasta scores%3B opt: 223 z-score: 329.2 E(): 4.2e-11%2C 39.8%25 identity in 113 aa overlap gene gene6078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6015 SCO6016 SCO6016 SC1C3.04 SC1C3.04 6599193 6600001 + gene gene6079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6016 SCO6018 SCO6018 SC1C3.06 SC1C3.06 6600024 6601049 + hypothetical protein SC1C3.06%2C unknown%2C len: 341 aa%3B similar to downsteam CDS SC1C3.07 (E(): 2.3e-19%2C 36.2%25 identity in 348 aa overlap%2C and to C-terminus of SC1C3.13 (E(): 3.7e-09%2C 32.0%25 identity in 356 aa overlap) gene gene6080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6018 SCO6019 SCO6019 SC1C3.07 SC1C3.07 6601234 6602355 + hypothetical protein SC1C3.07%2C unknown%2C len: 373 aa%3B similar to upstream gene SC1C3.06 (E(): 2.1e-21%2C 36.2%25 identity in 348 aa overlap) and to C-terminus of SC1C3.13 (E(): 1.8e-18%2C 31.8%25 identity in 337 aa overlap) gene gene6081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6019 SCO6020 SCO6020 SC1C3.08c SC1C3.08c 6602452 6603552 - transcriptional regulator SC1C3.08c%2C possible transcriptional regulator%2C len: 366 aa%3B some similarity to many transcriptional regulators%2C e.g. TR:P96499 (EMBL:U56901) B. subtilis transcriptional regulator YVHJ (391 aa)%2C fasta scores%3B opt:283 z-score: 276.9 E(): 3.4e-08%2C 28.2%25 identity in 365 aaoverlap. Contains Highly basic N-terminus%2C followed by hydrophobic region (possibly transmembrane) gene gene6082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6020 SCO6021 SCO6021 SC1C3.09 SC1C3.09 6603996 6605621 + hypothetical protein SC1C3.09%2C unknown%2C len: 541 aa%3B some similarity to hypothetical proteins e.g. M. tuberculosis TR:O06628 (EMBL:Z95618) MTCY07H7A.03 (532 aa)%2C fasta scores%3B opt: 897 z-score: 779.8 E(): 0%2C 35.4%25 identity in 525 aa overlap. Also similar to two genes linked to capsular polysaccharide biosynthesis genes in Neisseria meningitidis: TR:Q51151 (EMBL:L09188) (373 aa)%2C fasta scores%3B opt: 547 z-score: 579.0 E(): 5.1e-25%2C 29.3%25 identity in 355 aa overlap and TR:G2979674 (EMBL:AF019760) SACB (545 aa)%2C fasta scores%3B opt: opt: 594 z-score: 550.3 E(): 2e-23%2C 31.4%25 identity in 322 aa overlap. Also smilar to downstream genes SC1C3.11 (E(): 0%2C 47.7%25 identity in 509 aa overlap) and SC1C3.10 (E(): 1.6e-16%2C 28.0%25 identity in 542 aa overlap) gene gene6083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6021 SCO6022 SCO6022 SC1C3.10 SC1C3.10 6605637 6607259 + hypothetical protein SC1C3.10%2C unknown%2C len: 540 aa%3B some similarity to hypothetical proteins e.g. M. tuberculosis TR:O06628 (EMBL:Z95618) MTCY07H7A.03 (532 aa)%2C fasta scores%3B opt: 151 z-score: 278.3 E(): 2.8e-08%2C 25.9%25 identity in 529 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature%2C though this may be spurious. Also similar to flanking genes SC1C3.11 (E(): 2.5e-20%2C 29.0%25 identity in 583 aa overlap) and SC1C3.09 (E(): 1.1e-14%2C 28.0%25 identity in 542 aa overlap) gene gene6084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6022 SCO6023 SCO6023 SC1C3.11 SC1C3.11 6607256 6609016 + hypothetical protein SC1C3.11%2C unknown%2C len: 586 aa%3B some similarity to hypothetical proteins e.g. M. tuberculosis TR:O06628 (EMBL:Z95618) MTCY07H7A.03 (532 aa)%2C fasta scores%3B opt: 885 z-score: 918.8 E(): 0%2C 36.0%25 identity in 500 aa overlap. Also similar to two genes linked to capsular polysaccharide biosynthesis genes in Neisseria meningitidis: TR:Q51151 (EMBL:L09188) (373 aa)%2C fasta scores%3B opt: 561 z-score: 537.2 E(): 1.1e-22%2C 29.8%25 identity in 326 aa overlap and TR:G2979674 (EMBL:AF019760) SACB (545 aa)%2C fasta scores%3B opt: 678 z-score: 482.7 E(): 1.2e-19%2C 32.5%25 identity in 323 aa overlap. Also similar to upstream genes SC1C3.09 (E(): 0%2C 47.9%25 identity in 511 aa overlap) and SC1C3.10 (E(): 1.3e-23%2C 29.3%25 identity in 584 aa overlap) gene gene6085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6023 SCO6024 SCO6024 SC1C3.12 SC1C3.12 6609013 6611106 + transferase SC1C3.12%2C possible transferase%2C len: 697 aa%3B weakly similar to many polysaccharide biosynthesis proteins and to transferases e.g. Rhizobium leguminosarum TR:G2944086 (EMBL:AF050103) mannosyl transferase (352 aa)%2C fasta scores%3B opt: 204 z-score: 193.1 E(): 0.0016%2C 28.0%25 identityin 239 aa overlap gene gene6086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6024 SCO6025 SCO6025 SC1C3.13 SC1C3.13 6611138 6613105 + hypothetical protein SC1C3.13%2C unknown%2C len: 655 aa%3B C-terminus is similar to upstream genes TR:O69849 (EMBL:AL023702) SC1C3.07 (opt: 399 Z-score: 441.0 E(): 6.2e-17%3B 31.751%25 identity in 337 aa overlap) and TR:O69848 (EMBL:AL023702) SC1C3.06 (opt: 428 Z-score: 473.3 E(): 9.9e-19%3B 32.022%25 identity in 356 aa overlap) gene gene6087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6025 SCO6026 SCO6026 SC1C3.14c SC1C3.14c 6613171 6615300 - fatty acid oxidation complex alpha-subunit SC1C3.14c%2C probable fatty acid oxidation complex alpha-subunit%2C similar to many e.g. FADB_ECOLI (729 aa)%2C fasta scores%3B opt: 782 z-score: 863.1 E(): 0%2C 29.8%25 identity in671 aa overlap. Contains Pfam match to entry ECH PF00378%2C Enoyl-CoA hydratase/isomerase%2C score 49.78 gene gene6088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6026 SCO6027 SCO6027 SC1C3.15c SC1C3.15c 6615297 6616514 - acetyl-CoA acetyltransferase SC1C3.15c%2C probable acetyl-coA acetyltransferase (thiolase)%2C len: 405 aa%3B similar to many e.g. E. coli TR:E242886 (EMBL:X97452 acetyl-coA acetyltransferase paaJ (401 aa)%2C fasta scores%3B opt: 718 z-score: 1313.7 E(): 0%2C 42.6%25 identity in 408 aa overlap. Contains Pfam match to entry thiolase PF00108%2C Thiolases%2C score 410.31 gene gene6089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6027 SCO6028 SCO6028 SC1C3.16c SC1C3.16c 6616708 6617892 - ribonuclease SC1C3.16c%2C possible ribonuclease%2C len: 394 aa%3B similar to hypothetical proteins e.g. M. tuberculosis TR:O07183 (EMBL:Z96072) MTCY05A6.02 (438 aa)%2C fasta scores%3B opt: 1338 z-score: 1167.9 E(): 0%2C 51.9%25 identity in 405 aa overlap gene gene6090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6028 SCO6029 SCO6029 SC1C3.17c SC1C3.17c 6618177 6618839 - two-component regulator SC1C3.17c%2C probable two-component regulator%2C len: 220 aa%3B similar to many e.g. DEGU_BACSU transcriptional regulatory protein degU (229 aa)%2C fasta scores%3B opt: 168 z-score: 264.1 E(): 1.8e-07%2C 27.4%25 identity in 223 aa overlap. PS00622 Bacterial regulatory proteins%2C luxR family signature. Contains Pfam match to entry GerE PF00196%2C Bacterial regulatory proteins%2C luxR family%2C score 83.75 and to entry response_reg PF00072%2C Response regulator receiver domain%2C score 36.16 gene gene6091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6029 SCO6030 SCO6030 SC1C3.18c SC1C3.18c 6619133 6619849 - hypothetical protein SC1C3.18c%2C unknown%2C len: 238 aa%3B similar to M. tuberculosis hypothetical protein TR:E1237486 (EMBL:AL021186) MTV010.04 (244 aa)%2C fasta scores%3B opt: 516 z-score: 539.2 E(): 8.4e-23%2C 41.7%25 identity in 223 aa overlap gene gene6092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6030 SCO6031 SCO6031 hemE hemE 6620001 6621068 + uroporphyrinogen decarboxylase catalyzes the formation of coproporphyrinogen from uroporphyrinogen III gene gene6093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6031 SCO6032 SCO6032 SC1C3.20c SC1C3.20c 6621097 6622617 - hydrolase SC1C3.20c%2C possible hydrolase%2C len: 506 aa%3B weakly similar to many e.g. HEXA_ALTSO beta-hexosaminidase a precursor (598 aa)%2C fasta scores%3B opt: 463 z-score: 613.4 E(): 6.2e-27%2C 29.7%25 identity in 526 aa overlap gene gene6094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6032 SCO6033 SCO6033 SC1C3.21 SC1C3.21 6623033 6624127 + hypothetical protein SC1C3.21%2C unknown%2C len: 364 aa gene gene6095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6033 SCO6034 SCO6034 SC1C3.22 SC1C3.22 6624109 6625437 + hypothetical protein SC1C3.22%2C unknown%2C len: 442 aa%3B contains TTA Leu codon: possible target for action of bldA gene gene6096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6034 SCO6035 SCO6035 SC1C3.23 SC1C3.23 6625434 6626642 + lysine/ornithine decarboxylase SC1C3.23%2C possible lysine/ornithine decarboxylase%2C len: 402 aa%3B simlar to Selenomonas ruminantium TR:D1025847 (EMBL:AB011029) lysine/ornithine decarboxylase (EC 4.1.1.17) Ldc (393 aa)%2C fasta scores%3B opt: 407 z-score: 521.2 E():8.4e-22%2C 32.8%25 identity in 387 aa overlap%2C and to many eukaryotic ornithine decarboxylases e.g. DCOR_CHICK ornithine decarboxylase (EC 4.1.1.17) (Odc) (450 aa)%2C fasta scores%3B opt: 407 z-score: 413.4 E(): 8.6e-16%2C 28.8%25 identity in 386 aa overlap. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site and PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2 and Pfam match to entry Orn_DAP_Arg_deC PF00278%2C Pyridoxal-dependent decarboxylases acting on ornithine%2C lysine%2C arginine and related substrates%2C score 188.77 gene gene6097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6035 SCO6036 SCO6036 SC1C3.24 SC1C3.24 6626635 6627204 + hypothetical protein SC1C3.24%2C unknown%2C len: 189 aa gene gene6098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6036 SCO6037 SCO6037 SC1C3.25 SC1C3.25 6627211 6628443 + transmembrane transport protein SC1C3.25%2C possible transmembrane transport protein%2C len: 410 aa%3B similar to e.g. Rhizobium meliloti MOSC_RHIMEmembrane protein mosC (407 aa)%2C fasta scores%3B opt: 290 z-score: 488.8 E(): 5.4e-20%2C 29.1%25 identity in 392 aa overlap gene gene6099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6037 SCO6038 SCO6038 SC1C3.26c SC1C3.26c 6628480 6629631 - hypothetical protein SC1C3.26c%2C probable integral membrane protein%2C len:383 aa%3B start uncertain%2C similar to hypothetical proteins e.g. Aquifex aeolicus TR:G2983747 (EMBL:AE000734) AQ_1327 (227 aa)%2C fasta scores%3B opt: 472 z-score: 416.5 E(): 5.7e-16%2C 37.5%25 identity in 261 aa overlap. Contains PS00141 Eukaryotic and viral aspartyl proteases active site gene gene6100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6038 SCO6039 SCO6039 SC1C3.27c SC1C3.27c 6629805 6631202 - flavoprotein oxidoreductase SC1C3.27c%2C probable flavoprotein oxidoreductase%2C len: 465 aa%3B similar to many e.g. NAPE_ENTFA NADH peroxidase (EC 1.11.1.1) (447 aa)%2C fasta scores%3B opt: 642 z-score: 669.2 E(): 4.8e-30%2C 29.6%25 identity in 453 aa overlap gene gene6101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6039 SCO6040 SCO6040 SC1C3.28c SC1C3.28c 6631230 6632213 - lipoprotein SC1C3.28c%2C probable lipoprotein%2C len: 327 aa%3B contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene6102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6040 SCO6041 SCO6041 SC1B5.01 SC1B5.01 6632494 6633978 + protoporphyrinogen oxidase SC1B5.01%2C possible hemY%2C protoporphyrinogen oxidase%2C partial CDS%2C len: > 468 aa%3B similar to many e.g. HEMG_BACSU P32397 bacillus subtilis. protoporphyrinogen oxidase (470 aa)%2C fasta scores%3B opt: 741 z-score: 711.8 E(): 2e-32%2C 32.9%25 identity in 453 aa overlap~SC1C3.29%2C possible hemY%2C protoporphyrinogen oxidase%2C partial CDS%2C len: > 61 aa%3B overlaps and ecxtends CDS from overlapping cosmid%2C SC1B5.01 gene gene6103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6041 SCO6042 SCO6042 SC1B5.02 SC1B5.02 6633983 6634714 + hypothetical protein SC1B5.02%2C unknown%2C len: 243 aa%3B similar to hypothetical protein downstream of M. tuberculosis HemY%3B TR:P71973 (EMBL:Z80225) MTCY441.45C (296 aa)%2C fasta scores%3B opt: 917 z-score: 1481.6 E(): 0%2C 59.1%25 identity in 237 aa overlap gene gene6104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6042 SCO6043 SCO6043 SC1B5.03c SC1B5.03c 6634715 6636346 - protease SC1B5.03c%2C probable protease%2C len: 543 aa%3Bsimilar to e.g. Streptomyces lividans TR:Q54410 (EMBL:L27466) tripeptidylaminopeptidase (537 aa)%2C fasta scores%3B opt: 1839 z-score: 1633.9 E(): 0%2C 51.9%25 identity in 538 aa overlap. Contains possible N-terminal signal sequence gene gene6105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6043 SCO6044 SCO6044 SC1B5.04c SC1B5.04c 6636431 6637228 - hypothetical protein SC1B5.04c%2C possible integral membrane protein%2C len: 265 aa gene gene6106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6044 SCO6045 SCO6045 SC1B5.05c SC1B5.05c 6637343 6638659 - hypothetical protein SC1B5.05c%2C unknown%2C len: 438 aa%3B slight similarity to hypothetical protein from Haemophilus influenzae YG00_HAEIN P44268 (317 aa)%2C fasta scores%3B opt: 252 z-score: 283.4 E(): 1.5e-08%2C 26.8%25 identity in 298 aa overlap gene gene6107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6045 SCO6046 SCO6046 SC1B5.06c SC1B5.06c 6638803 6639552 - hypothetical protein SC1B5.06c%2C unknown%2C len: 249 aa gene gene6108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6046 SCO6047 SCO6047 SC1B5.07 SC1B5.07 6639597 6640451 + ABC transporter ATP-binding protein SC1B5.07%2C probable ABC-transporter ATP-binding protein%2C len: 284 aa%3B similar to many e.g. NOSF_PSEST P19844 pseudomonas stutzeri copper transport atp-binding protein nosF (308 aa)%2C fasta scores%3B opt: 327 z-score: 381.3 E(): 5.2e-14%2C 30.5%25 identity in 292 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry ABC_tran PF00005%2C ABC transporters%2C score 126.83 gene gene6109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6047 SCO6048 SCO6048 SC1B5.08 SC1B5.08 6640448 6641122 + hypothetical protein SC1B5.08%2C probable integral membrane protein%2C len: 224 aa%3B contains six possible transmembrane domains. gene gene6110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6048 SCO6049 SCO6049 SC1B5.09c SC1B5.09c 6641114 6641344 - hypothetical protein SC1B5.09c%2C unknown%2C len: 76 aa gene gene6111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6049 SCO6050 SCO6050 SC1B5.10c SC1B5.10c 6641362 6642231 - lipoprotein SC1B5.10c%2C probable lipoprotein%2C len: 289 aa%3B contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6050 SCO6051 SCO6051 SC1B5.11c SC1B5.11c 6642322 6643863 - iron-sulfur binding oxidoreductase SC1B5.11c%2C probable iron-sulfur binding oxidoreductase%2C len: 513 aa%3B similar to e.g. ORDL_ECOLI P37906 escherichia coli. probable oxidoreductase (426 aa)%2C fasta scores%3B opt: 303 z-score: 334.4 E(): 2.1e-11%2C 25.4%25 identity in 389 aa overlap. Contains PS00199 and PS00200 Rieske iron-sulfur protein signatures 1 and 2%2C and Pfam match to entry Rieske PF00355%2C Rieske iron-sulfur protein%2C score 49.39 gene gene6113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6051 SCO6052 SCO6052 SC1B5.12c SC1B5.12c 6643915 6645312 - hypothetical protein SC1B5.12c%2C membrane protein%2C len: 495 aa%3B similar to TR:Q9X9W6 (EMBL:AL096743) Streptomyces coelicolor hypothetical protein SCI7.24c%2C 490 aa%3B fasta scores: opt: 1059 Z-score: 1198.3 E(): 4.1e-59%3B 48.081%25 identity in 495 aa overlap. Contains possible hydrophobic membrane spanning region gene gene6114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6052 SCO6053 SCO6053 SC1B5.13c SC1B5.13c 6645402 6646190 - hypothetical protein SC1B5.13c%2C membrane protein%2C len: 262 aa%3B highly similar to many members of the band 7/mec2 family of membrane proteins e.g. BAN7_MOUSE P54116 mus musculus (mouse). erythrocyte band7 protein (stomatin) (284 aa)%2C fasta scores%3B opt: 709 z-score: 1075.9 E(): 0%2C 47.1%25 identity in 223 aa overlap. Contains possible hydrophobic membrane spanning region gene gene6115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6053 SCO6054 SCO6054 SC1B5.14c SC1B5.14c 6646291 6647781 - transmembrane transport protein SC9B1.01c%2C partial CDS%2C possible integral membrane protein%2C len: >149aa%3B similar to many eg. TR:CAB38499 (EMBL:AL035636) integral membrane protein from Streptomyces coelicolor (830 aa) fasta scores%3B opt: 385%2C z-score: 428.6%2C E(): 1.5e-16%2C (44.7%25 identity in 141 aa overlap). Contains several possible membrane spanning hydrophobic regions.~SC1B5.14c%2C probable transmembrane transport protein%2C partial CDS%2C len: >381 aa%3B similar to hypothetical membrane proteins from many organisms e.g. Mycobacterium tuberculosis TR:P96878 (EMBL:Z92771) MTCY71.13 (764 aa)%2C fasta scores%3B opt: 745 z-score: 768.6 E(): 0%2C 35.9%25 identity in 376 aa overlap and to eukaryotic sulfate transpoters TR:O04001 (EMBL:X96761) Sporobolus stapfianus sulphate transporter (660 aa)%2C opt: 191 z-score: 224.0 E(): 3e-05%2C 22.4%25 identity in 308 aa overlap gene gene6116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6054 SCO6055 SCO6055 SC9B1.02c SC9B1.02c 6647790 6648371 - carbonic anhydrase SC9B1.02c%2C probable carbonic anhydrase%2C len: 193aa%3B similar to many eg. SW:CYNT_ECOLI carbonic anhydrase from Escherichia coli (219 aa) fasta scores%3B opt: 512%2C z-score: 618.8%2C E(): 3.8e-27%2C (43.6%25 identity in 188 aa overlap). Contains two Pfam matches to entry PF00484 Pro_CA%2C Prokaryotic-type carbonic anhydrases and Prosite matches to PS00705 Prokaryotic-type carbonic anhydrases signature 2 and PS00704 Prokaryotic-type carbonic anhydrases signature 1. gene gene6117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6055 SCO6056 SCO6056 SC9B1.03c SC9B1.03c 6648450 6648851 - hypothetical protein SC9B1.03c%2C possible hypothetical protein%2C len: 133aa%3B contains possible N-terminal signal sequence. gene gene6118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6056 SCO6057 SCO6057 SC9B1.04c SC9B1.04c 6649041 6650093 - ATP/GTP-binding integral membrane protein SC9B1.04c%2C possible ATP/GTP-binding integral membrane protein%2C len: 350aa%3B similar to hypotheticals eg. TR:P71967 (EMBL:Z80225) from Mycobacterium tuberculosis (369 aa) fasta scores%3B opt: 1129%2C z-score: 1182.3%2C E(): 0%2C (57.8%25 identity in 325 aa overlap). Contains possible membrane spanning hydrophobic regions. Also contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6057 SCO6058 SCO6058 SC9B1.05 SC9B1.05 6650674 6651471 + hypothetical protein SC9B1.05%2C possible hydrolase%2C len: 265aa%3B similar to hypotheticals eg. TR:P71968 (EMBL:Z80225) from Mycobacterium tuberculosis (258 aa) fasta scores%3B opt: 536%2C z-score: 585.9%2C E(): 2.6e-25%2C (44.3%25 identity in 235 aa overlap). Also similar to several proposed ribofavin deaminases eg. SW:RIBG_BACAM ribofavin-specific deaminase from Bacillus subtilis (371 aa) fasta scores%3B opt: 157%2C z-score: 177.0%2C E(): 0.015%2C (28.3%25 identity in 180 aa overlap). gene gene6120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6058 SCO6059 SCO6059 SC9B1.06 SC9B1.06 6651616 6652161 + hypothetical protein SC9B1.06%2C unknown%2C len: 181 aa gene gene6121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6059 SCO6060 SCO6060 murC murC 6652235 6653623 + UDP-N-acetylmuramoyl-L-alanine ligase SC9B1.07%2C murC%2C possible UDP-N-acetylmuramoyl-L-alanine ligase%2C len: 485 aa%3B similar to many e.g. SW:MURC_ECOLI UDP-N-acetylmuramoyl-L-alanine ligase from Escherichia coli (491 aa) fasta scores%3B opt: 750%2C z-score: 785.9%2C E(): 0%2C (40.4%25 identity in 463 aa overlap). gene gene6122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6060 SCO6061 SCO6061 SC9B1.08 SC9B1.08 6653637 6654044 + oxidoreductase SC9B1.08%2C possible oxidoreductase%2C len: 135aa%3B highly conserved in prokaryotes and eukaryotes eg. TR:P71971 (EMBL:Z80225) from Mycobacterium tuberculosis (136 aa) fasta scores%3B opt: 653%2C z-score: 835.9%2C E(): 0%2C (71.1%25 identity in 128 aa overlap) and TR:CAB40164 (EMBL:AL049558) from Schizosaccharomyces pombe (138 aa) fasta scores%3B opt: 475%2C z-score: 612.0%2C E(): 9e-27%2C (48.1%25 identity in 135 aa overlap). Also similar to SW:PMSR_STRPN Peptide methionine sulfoxide reductase from Streptococcus pneumoniae (312 aa) fasta scores%3B opt: 331%2C z-score: 426.0%2C E(): 2.1e-16%2C (46.2%25 identity in 132 aa overlap). gene gene6123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6061 SCO6062 SCO6062 SC9B1.09 SC9B1.09 6654298 6655458 + ABC transporter ATP-binding protein SC9B1.09%2C ABC transporter ATP-binding subunit%2C len: 386aa%3B similar to many eg. TR:O69724 (EMBL:AL022121) ABC transporter ATP-binding subunit from Mycobacterium tuberculosis (376 aa) fasta scores%3B opt: 1147%2C z-score: 1185.4%2C E(): 0%2C (51.2%25 identity in 371 aa overlap) and SW:PROV_BACSU glycine/betaine/L-proline transport ATP-binding protein (404 aa) fasta scores%3B opt: 849%2C z-score: 879.1%2C E(): 0%2C (39.8%25 identity in 359 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. gene gene6124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6062 SCO6063 SCO6063 SC9B1.10 SC9B1.10 6655455 6656168 + ABC transporter permease SC9B1.10%2C probable ABC transport permease%2C len: 237aa%3B similar to many eg. TR:O69723 (EMBL:AL022121) transport system permease from Mycobacterium tuberculosis (229 aa) fasta scores%3B opt: 436%2C z-score: 523.9%2C E(): 7.4e-22%2C (36.4%25 identity in 214 aa overlap) and SW:PROZ_BACSU glycine/betaine/L-proline transport permease from Bacillus subtilis (223 aa) fasta scores%3B opt: 291%2C z-score: 353.3%2C E(): 2.3e-12%2C (29.1%25 identity in 199 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene6125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6063 SCO6064 SCO6064 SC9B1.11 SC9B1.11 6656165 6656830 + ABC transporter permease gene gene6126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6064 SCO6065 SCO6065 SC9B1.12 SC9B1.12 6656904 6657866 + substrate-binding protein SC9B1.12%2C probable substrate-binding protein%2C len: 320aa%3B similar to many eg. TR:O69725 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (315 aa) fasta scores%3B opt: 574%2C z-score: 637.7%2C E(): 3.4e-28%2C (35.8%25 identity in 313 aa overlap) and SW:PROX_BACSU glycine/betaine/L-proline binding protein from Bacillus subtilis (313 aa) fasta scores%3B opt: 136%2C z-score: 157.8%2C E(): 0.18%2C (25.7%25 identity in 311 aa overlap). Contains possible N-terminal signal sequence. gene gene6127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6065 SCO6066 SCO6066 cvnD6 cvnD6 6657898 6658443 - ATP/GTP-binding protein SC9B1.13c%2C cvnD6%2C possible ATP/GTP-binding protein%2C len: 181aa%3B similar to others egs. TR:O50391 (EMBL:AL009198) hypothetical protein from Mycobacterium tuberculosis (193 aa) fasta scores%3B opt: 689%2C z-score: 849.1%2C E(): 0%2C (61.4%25 identity in 166 aa overlap) and two ATP/GTP-binding proteins from Streptomyces coelicolor: TR:O86519 (EMBL:AL031124) (174 aa) fasta scores%3B opt: 665%2C z-score: 820.6%2C E(): 0%2C (55.0%25 identity in 171 aa overlap) and TR:CAA19989 (EMBL:AL031124) (174 aa) fasta scores%3B opt: 662%2C z-score: 817.0%2C E(): 0%2C (55.6%25 identity in 171 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6066 SCO6067 SCO6067 cvnC6 cvnC6 6658496 6658855 - hypothetical protein SC9B1.14c%2C cvnC6%2C unknown%2C len: 119 aa%3B similar to other hypothetical proteins egs. two from Streptomyces coelicolor: TR:O86520 (EMBL:AL031124) (190 aa) fasta scores%3B opt: 242%2C z-score: 321.0%2C E(): 1.5e-10%2C (39.8%25 identity in 118 aa overlap) and TR:O86523 (EMBL:AL031124) (132 aa) fasta scores%3B opt: 228%2C z-score: 305.7%2C E(): 1e-09%2C (39.3%25 identity in 112 aa overlap)%2C and TR:O50392 (EMBL:AL009198) from Mycobacterium tuberculosis (122 aa) fasta scores%3B opt: 188%2C z-score: 255.2%2C E(): 6.8e-07%2C (37.5%25 identity in 120 aa overlap). gene gene6129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6067 SCO6068 SCO6068 cvnB6 cvnB6 6658857 6659276 - hypothetical protein SC9B1.15c%2C cvnB6%2C unknown%2C len: 119 aa%3B similar to other hypothetical proteins egs. two from Streptomyces coelicolor: TR:O86521 (EMBL:AL031124) (140 aa) fasta scores%3B opt: 331%2C z-score: 424.2%2C E(): 2.6e-16%2C (41.5%25 identity in 130 aa overlap) and TR:O86524 (EMBL:AL031124) (137 aa) fasta scores%3B opt: 325%2C z-score: 416.9%2C E(): 6.7e-16%2C (44.3%25 identity in 122 aa overlap)%2C and TR:O50393 (EMBL:AL009198) from Mycobacterium tuberculosis (130 aa) fasta scores%3B opt: 282%2C z-score: 364.1%2C E(): 5.8e-13%2C (39.1%25 identity in 115 aa overlap). gene gene6130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6068 SCO6069 SCO6069 cvnA6 cvnA6 6659273 6661906 - large hypothetical protein SC9B1.16c%2C cvnA6%2C possible large hypothetical protein%2C len: 877aa%3B similar to two neighbouring hypothetical proteins from Streptomyces coelicolor TR:O86525 (EMBL:AL031124) (1329 aa) fasta scores%3B opt: 1056%2C z-score: 919.5%2C E(): 0%2C (30.4%25 identity in 891 aa overlap) TR:O86522 (EMBL:AL031124) (1111 aa) fasta scores%3B opt: 804%2C z-score: 701.8%2C E(): 9e-32%2C (28.4%25 identity in 849 aa overlap). Contains possible N-terminal signal sequence. gene gene6131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6069 SCO6070 SCO6070 SC9B1.17c SC9B1.17c 6661975 6662988 - solute binding protein SC9B1.17c%2C possible solute binding protein%2C len: 337aa%3B similarity to many eg. SW:RBSB_BACSU D-ribose binding protein from Bacillus subtilis (305 aa) fasta scores%3B opt: 251%2C z-score: 270.5%2C E(): 9.6e-08%2C (26.4%25 identity in 288 aa overlap). Contains possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene6132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6070 SCO6071 SCO6071 cprB cprB 6663344 6663991 + A-factor receptor-like protein SC9B1.18%2C cprB%2C A-factor receptor homolog%2C len: 215 aa%3B previously sequenced therefore identical to TR:O66122 (EMBL:AB000385) CprB%2C A-factor receptor homolog from Streptomyces coelicolor. Also similar to many others from Actinomycetes e.g. TR:Q54189 (EMBL:D49782) A-factor receptor from Streptomyces griseus (276 aa) fasta scores%3B opt: 315%2C z-score: 392.1%2C E(): 1.6e-14%2C (36.5%25 identity in 219 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene6133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6071 SCO6072 SCO6072 SC9B1.19 SC9B1.19 6664069 6666069 + hypothetical protein SC9B1.19%2C unknown%2C len: 666aa%3B similar to many hypothetical proteins from eukaryotes eg. TR:O45417 (EMBL:Z92832) from Caenorhabditis elegans (450 aa) fasta scores%3B opt: 395%2C z-score: 410.1%2C E(): 1.6e-15%2C (28.0%25 identity in 447 aa overlap). gene gene6134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6072 SCO6073 SCO6073 SC9B1.20 SC9B1.20 6666219 6668399 + cyclase SC9B1.20%2C possible cyclase%2C len: 726 aa%3B C-terminal region similar to SW:PTLS_STRSQ pentalenene synthase from Streptomyces UC5319 (336 aa) fasta scores%3B opt: 382%2C z-score: 446.4%2C E(): 1.5e-17%2C (28.9%25 identity in 339 aa overlap). gene gene6135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6073 SCO6074 SCO6074 SC9B1.21 SC9B1.21 6668513 6669124 + hypothetical protein SC9B1.21%2C possible integral membrane protein%2C len: 203aa%3B some similarity to eukaryotic hypothetical proteins eg. TR:Q22260 (EMBL:Z70756) (290 aa) fasta scores%3B opt: 185%2C z-score: 170.7%2C E(): 0.035%2C (34.4%25 identity in 157 aa overlap). Also similar to TR:CAA22418 (EMBL:AL034447) transmembrane protein from Streptomyces coelicolor (396 aa) fasta scores%3B opt: 186%2C z-score: 169.8%2C E(): 0.039%2C (33.1%25 identity in 166 aa overlap). gene gene6136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6074 SCO6075 SCO6075 SC9B1.22c SC9B1.22c 6669117 6669938 - hypothetical protein SC9B1.22c%2C unknown%2C len: 273aa%3B similar to many hypothetical proteins eg. TR:O06629 (EMBL:Z95618) from Mycobacterium tuberculosis (318 aa) fasta scores%3B opt: 353%2C z-score: 408.1%2C E(): 2.1e-15%2C (32.5%25 identity in 252 aa overlap). gene gene6137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6075 SCO6076 SCO6076 SC9B1.23 SC9B1.23 6670057 6671187 + dipeptidase SC9B1.23%2C probable dipeptidase%2C len: 376aa%3B similar to many eg. SW:PEPQ_LACDL proline dipeptidase from Lactobacillus delbrueckii subsp. lactis DSM7290 (368 aa) fasta scores%3B opt: 681%2C z-score: 740.0%2C E(): 0%2C (34.6%25 identity in 353 aa overlap). gene gene6138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6076 SCO6077 SCO6077 SC9B1.24 SC9B1.24 6671184 6672188 + transferase SCBAC1A6.01%2C unknown (fragment)%2C len: >60 aa~SC9B1.24%2C partial CDS%2C possible transferase%2C len: >317aa%3B similarity to many antibiotic resistance phosphotransferases eg. TR:Q47396 (EMBL:D16251) macrolide 2'-phosphotransferase I from Escherichia coli (301 aa) fasta scores%3B opt: 197%2C z-score: 224.6%2C E(): 3.4e-05%2C (26.9%25 identity in 201 aa overlap) and SW:VPH_STRVI viomycin phosphotransferase from Streptomyces vinaceus (287 aa) fasta scores%3B opt: 194%2C z-score: 221.6%2C E(): 5e-05%2C (28.8%25 identity in 257 aa overlap). gene gene6139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6077 SCO6078 SCO6078 SCBAC1A6.02c SCBAC1A6.02c 6672199 6673944 - alpha amylase SCBAC1A6.02c%2C probable alpha amylase%2C len: 581 aa%3B highly similar to TR:Q44316 (EMBL:D63343) Arthrobacter sp. maltooligosyl trehalose trehalohydrolase TreZ%2C 598 aa%3B fasta scores: opt: 2063 z-score: 2298.1 E(): 0%3B 53.3%25 identity in 583 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene6140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6078 SCO6079 SCO6079 SCBAC1A6.03 SCBAC1A6.03 6674122 6674673 + hypothetical protein SCBAC1A6.03%2C conserved hypothetical protein%2C len: 183 aa%3B similar to TR:Q9RP36 (EMBL:AF173844) Mycobacterium smegmatis signal transduction protein GarA%2C 158 aa%3B fasta scores: opt: 185 z-score: 231.8 E(): 2.5e-05%3B 36.4%25 identity in 143 aa overlap. Contains Pfam match to entry PF00498 FHA%2C FHA domain gene gene6141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6079 SCO6080 SCO6080 SCBAC1A6.04 SCBAC1A6.04 6675067 6676224 + dehydrogenase SCBAC1A6.04%2C possible dehydrogenase%2C len: 385 aa%3B similar to TR:Q53924 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORFB%2C 394 aa%3B fasta scores: opt: 835 z-score: 981.3 E(): 0%3B 42.0%25 identity in 381 aa overlap gene gene6142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6080 SCO6081 SCO6081 SCBAC1A6.05c SCBAC1A6.05c 6676232 6678649 - alpha amylase SCBAC1A6.05c%2C probable alpha amylase%2C len: 805 aa%3B similar to TR:Q53237 (EMBL:D78001) Rhizobium sp. maltooligosyl trehalose synthase TreY%2C 772 aa%3B fasta scores: opt: 1007 z-score: 1085.4 E(): 0%3B 42.8%25 identity in 797 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene6143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6081 SCO6082 SCO6082 glgX3 glgX3 6678718 6680826 - glycogen debranching protein SCBAC1A6.06c%2C glgX3%2C glycogen debranching enzyme%2C len: 702 aa%3B similar to SW:GLGX_ECOLI (EMBL:J01616) Escherichia coli glycogen operon protein GlgX or GlyX (EC 3.2.1.*)%2C 657 aa%3B fasta scores: opt: 1883 z-score: 2219.2 E(): 0%3B 45.5%25 identity in 664 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase gene gene6144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6082 SCO6083 SCO6083 SCBAC1A6.07 SCBAC1A6.07 6681383 6682630 + hypothetical protein SCBAC1A6.07%2C unknown%2C len: 415 aa gene gene6145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6083 SCO6084 SCO6084 SCBAC1A6.08 SCBAC1A6.08 6682745 6683479 + DNA polymerase III subunit epsilon 3'-5' exonuclease of DNA polymerase III gene gene6146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6084 SCO6085 SCO6085 SCBAC1A6.09c SCBAC1A6.09c 6683518 6684384 - hypothetical protein SCBAC1A6.09c%2C hypothetical protein%2C len: 288 aa%3B similar to TR:Q9KZD8 (EMBL:AL353870) Streptomyces coelicolor hypothetical 32.2 kDa protein SC6F7.04%2C 293 aa%3B fasta scores: opt: 459 z-score: 531.9 E(): 4.7e-22%3B 36.5%25 identity in 293 aa overlap gene gene6147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6085 SCO6086 SCO6086 SCBAC1A6.10 SCBAC1A6.10 6684546 6685493 + transport system integral membrane protein SCBAC1A6.10%2C probable transport system integral membrane protein%2C len: 315 aa%3B similar to TR:P73352 (EMBL:D90905) Synechocystis sp. lactose transport system permease LacF%2C 298 aa%3B fasta scores: opt: 630 z-score: 734.0 E(): 0%3B 38.6%25 identity in 298 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and possible hydrophobic membrane spanning regions gene gene6148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6086 SCO6087 SCO6087 SCBAC1A6.11 SCBAC1A6.11 6685490 6686323 + transport system integral membrane protein SCBAC1A6.11%2C probable transport system integral membrane protein%2C len: 277 aa%3B similar to TR:Q9L1V0 (EMBL:AL138851) Streptomyces coelicolor sugar transporter inner membrane protein SCE59.03c%2C 281 aa%3B fasta scores: opt: 661 z-score: 794.5 E(): 0%3B 42.2%25 identity in 268 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and possible hydrophobic membrane spanning regions gene gene6149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6087 SCO6088 SCO6088 SCBAC1A6.12 SCBAC1A6.12 6686323 6687615 + solute-binding transport protein SCBAC1A6.12%2C possible solute-binding transport protein%2C len: 430 aa%3B similar to TR:Q9PAP7 (EMBL:AE004053) Xylella fastidiosa ABC transporter sugar-binding protein XF2448%2C 430 aa%3B fasta scores: opt: 351 z-score: 392.9 E(): 2.6e-14%3B 26.2%25 identity in 428 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and properly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene6150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6088 SCO6089 SCO6089 SCBAC1A6.13 SCBAC1A6.13 6687926 6688708 + antibiotic resistance rRNA adenine methyltransferase SCBAC1A6.13%2C antibiotic resistance rRNA adenine methyltransferase%2C len: 260 aa%3B identical to TR:Q54386 (EMBL:M74717) Streptomyces lividans lincomycin resistance methylase Lrm%2C 260 aa and similar to many other macrolide antibiotic resistance proteins%2C e.g. SW:ERMS_STRFR (EMBL:M19269) Streptomyces fradiae rRNA adenine N-6-methyltransferase (EC 2.1.1.48) ErmSF%2C 319 aa%3B fasta scores: opt: 1003 z-score: 1217.4 E(): 0%3B 64.2%25 identity in 257 aa overlap. Contains Pfam match to entry PF00398 RrnaAD%2C Ribosomal RNA adenine dimethylase and match to Prosite entry PS01131 Ribosomal RNA adenine dimethylases signature gene gene6151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6089 SCO6090 SCO6090 SCBAC1A6.14 SCBAC1A6.14 6688705 6689961 + antibiotic resistance macrolide glycosyltransferase SCBAC1A6.14%2C antibiotic resistance macrolide glycosyltransferase%2C len: 418 aa%3B identical to SW:MGT_STRLI (EMBL:M74717) Streptomyces lividans macrolide glycosyltransferase (EC 2.4.1.*) Mgt%2C 418 aa. Contains Pfam match to entry PF00201 UDPGT%2C UDP-glucoronosyl and UDP-glucosyl transferases and match to Prosite entry PS00375 UDP-glycosyltransferases signature gene gene6152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6090 SCO6091 SCO6091 SCBAC1A6.15c SCBAC1A6.15c 6690041 6692311 - hypothetical protein SCBAC1A6.15c%2C probable integral membrane protein%2C len: 756 aa%3B similar to SW:MMLB_MYCTU (EMBL:AL021928) Mycobacterium tuberculosis membrane protein MmpL11 or MTV033.10c%2C 966 aa%3B fasta scores: opt: 1132 z-score: 1196.3 E(): 0%3B 32.6%25 identity in 723 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6091 SCO6092 SCO6092 SCBAC1A6.16 SCBAC1A6.16 6692660 6693208 + hypothetical protein SCBAC1A6.16%2C conserved hypothetical protein%2C len: 182 aa%3B similar to TR:O06552 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 23.0 kDa protein MTCI65.21c%2C 213 aa%3B fasta scores: opt: 229 z-score: 293.1 E(): 9.5e-09%3B 31.8%25 identity in 179 aa overlap gene gene6154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6092 SCO6093 SCO6093 SCBAC1A6.17c SCBAC1A6.17c 6693222 6693968 - hypothetical protein SCBAC1A6.17c%2C possible hypothetical protein%2C len: 248 aa%3B similar to TR:Q9L2E8 (EMBL:AL137187) Streptomyces coelicolor hypothetical protein SC7A8.10c%2C 274 aa%3B fasta scores: opt: 552 z-score: 639.4 E(): 4.9e-28%3B 45.7%25 identity in 234 aa overlap. Contains possible cleavable N-terminal region signal peptide sequence gene gene6155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6093 SCO6094 SCO6094 SCBAC1A6.18c SCBAC1A6.18c 6693977 6694888 - transport system integral membrane protein SCBAC1A6.18c%2C probable transport system integral membrane protein%2C len: 258 aa%3B similar to SW:SSUC_BACSU (EMBL:Z93102) Bacillus subtilis aliphatic sulfonates transport permease SsuC%2C 276 aa%3B fasta scores: opt: 378 z-score: 422.1 E(): 6.2e-16%3B 28.5%25 identity in 263 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene6156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6094 SCO6095 SCO6095 SCBAC1A6.19c SCBAC1A6.19c 6694875 6695669 - ABC transporter ATP-binding protein SCBAC1A6.19c%2C probable ABC transporter ATP-binding protein%2C len: 264 aa%3B similar to SW:SSUB_BACSU (EMBL:Z93102) Bacillus subtilis aliphatic sulfonates transport ATP-binding protein SsuB%2C 274 aa%3B fasta scores: opt: 628 z-score: 728.2 E(): 0%3B 46.1%25 identity in 217 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene6157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6095 SCO6096 SCO6096 SCBAC1A6.20c SCBAC1A6.20c 6695702 6696805 - lipoprotein SCBAC1A6.20c%2C probable lipoprotein%2C len: 367 aa%3B similar to SW:SSUA_BACSU (EMBL:L16808) Bacillus subtilis aliphatic sulfonates binding protein precursor SsuA%2C 332 aa%3B fasta scores: opt: 280 z-score: 316.7 E(): 4.6e-10%3B 28.2%25 identity in 358 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene6158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6096 SCO6097 SCO6097 cysN cysN 6697066 6698421 - sulfate adenylyltransferase subunit 1 SCBAC1A6.21c%2C cysN%2C sulfate adenylyltransferase subunit 1%2C len: 451 aa%3B similar to N-terminal domain of SW:CYSN_PSEAE (EMBL:AF035608) Pseudomonas aeruginosa CysN/CysC bifunctional enzyme%2C 633 aa%3B fasta scores: opt: 1232 z-score: 1300.1 E(): 0%3B 47.5%25 identity in 438 aa overlap and to SW:CYSN_ECOLI (EMBL:M74586) Escherichia coli sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) CysN%2C 475 aa%3B fasta scores: opt: 1192 z-score: 1259.9 E(): 0%3B 46.6%25 identity in 438 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU%2C Elongation factor Tu family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00301 GTP-binding elongation factors signature gene gene6159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6097 SCO6098 SCO6098 cysD cysD 6698424 6699362 - sulfate adenylyltransferase subunit 2 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP gene gene6160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6098 SCO6099 SCO6099 cysC cysC 6699359 6699895 - adenylyl-sulfate kinase SCBAC1A6.23c%2C cysC%2C adenylylsulfate kinase%2C len: 178 aa%3B highly similar to C-terminal region of SW:MET3_EMENI (EMBL:X82541) Emericella nidulans sulfate adenylyltransferase (EC 2.7.7.4) Sc%2C 574 aa%3B fasta scores: opt: 481 z-score: 561.7 E(): 1.1e-23%3B 46.0%25 identity in 174 aa overlap and to N-terminal region of SW:PPS1_HUMAN (EMBL:Y10387) Homo sapiens bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 [includes: sulfate adenylyltransferase (EC 2.7.7.4)%3B adenylylsulfate kinase (EC 2.7.1.25)] PapSS1 where the kinase activity is situated%2C 624 aa%3B fasta scores: opt: 476 z-score: 555.3 E(): 2.5e-23%3B 44.3%25 identity in 174 aa overlap. Contains Pfam match to entry PF01583 APS_kinase%2C Adenylylsulfate kinase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene6161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6099 SCO6100 SCO6100 cysH cysH 6700005 6700715 - phosphoadenosine phosphosulfate reductase catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite gene gene6162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6100 SCO6101 SCO6101 SCBAC1A6.25c SCBAC1A6.25c 6700712 6700891 - hypothetical protein SCBAC1A6.25c%2C unknown%2C len: 59 aa gene gene6163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6101 SCO6102 SCO6102 SCBAC1A6.26c SCBAC1A6.26c 6700888 6702585 - nitrite/sulfite reductase SCBAC1A6.26c%2C probable nitrite/sulphite reductase%2C len: 565 aa%3B similar to SW:NIR_SYNP7 (EMBL:D12723) Synechococcus sp. ferredoxin--nitrite reductase (EC 1.7.7.1) NirA%2C 512 aa%3B fasta scores: opt: 935 z-score: 1113.1 E(): 0%3B 35.6%25 identity in 525 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR%2C Nitrite and sulphite reductase 4Fe-4S domain gene gene6164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6102 SCO6103 SCO6103 SCBAC1A6.27c SCBAC1A6.27c 6702969 6703541 - acetyltransferase SCBAC1A6.27c%2C possible acetyltransferase%2C len: 190 aa. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene6165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6103 SCO6104 SCO6104 SCBAC1A6.28c SCBAC1A6.28c 6703618 6704931 - hypothetical protein SCBAC1A6.28c%2C possible hypothetical protein%2C len: 437 aa. Contains possible N-terminal region signal peptide sequence gene gene6166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6104 SCO6105 SCO6105 SCBAC1A6.29c SCBAC1A6.29c 6705148 6706437 - regulatory protein SCBAC1A6.29c%2C possible regulatory protein%2C len: 429 aa%3B N-terminal region similar to N-terminal region of TR:Q9RJZ7 (EMBL:AL133210) Streptomyces coelicolor transcriptional regulator SCF37.04%2C 419 aa%3B fasta scores: opt: 520 z-score: 594.4 E(): 1.6e-25%3B 40.8%25 identity in 240 aa overlap gene gene6167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6105 SCO6106 SCO6106 SCBAC1A6.30c SCBAC1A6.30c 6706680 6708353 - acyl-CoA dehydrogenase SCBAC1A6.30c%2C possible acyl-CoA dehydrogenase%2C len: 557 aa%3B similar to SW:AIDB_ECOLI (EMBL:L20915) Escherichia coli AidB protein%2C 541 aa%3B fasta scores: opt: 916 z-score: 1055.7 E(): 0%3B 45.5%25 identity in 539 aa overlap and to TR:CAC13064 (EMBL:AL445503) Streptomyces coelicolor oxidoreductase 2SCG38.05%2C 567 aa%3B fasta scores: opt: 1480 z-score: 1414.3 E(): 0%3B 61.8%25 identity in 555 aa overlap. Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and match to Prosite entry PS00072 Acyl-CoA dehydrogenases signature 1 and PS00073 Acyl-CoA dehydrogenases signature 2 gene gene6168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6106 SCO6107 SCO6107 SCBAC1A6.31 SCBAC1A6.31 6708580 6709614 + hypothetical protein SCBAC1A6.31%2C possible integral membrane protein%2C len: 344 aa%3B similar to TR:O07208 (EMBL:Z96072) Mycobacterium tuberculosis hypothetical 35.0 kDa protein MTCY05A6.28%2C 324 aa%3B fasta scores: opt: 593 z-score: 664.2 E(): 2e-29%3B 36.2%25 identity in 268 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6107 SCO6108 SCO6108 fusH fusH 6709909 6711471 + esterase SCBAC1A6.32%2C fusH%2C esterase%2C len: 520 aa%3B identical to TR:Q54344 (EMBL:Z50108) Streptomyces lividans esterase FusH%2C 520 aa. Contains Pfam match to entry PF00089 trypsin%2C Trypsin and a 3x degenerate repeat at C-terminal region: DLGRLYFADVDGDRKADMIVHT(S/G)DGN(I/V)EVRFNHGTYWDQGTHWSGGWGRF. Also contains possible hydrophobic membrane spanning region at N-terminal domain gene gene6170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6108 SCO6109 SCO6109 SCBAC1A6.33 SCBAC1A6.33 6711507 6713030 + hydrolase SCBAC1A6.33%2C probable hydrolase%2C len: 507 aa%3B similar to TR:Q54345 (EMBL:Z50108) Streptomyces lividans esterase precursor FusH%2C 509 aa%3B fasta scores: opt: 629 z-score: 651.1 E(): 1.1e-28%3B 33.2%25 identity in 515 aa overlap and to TR:CAC32668 (EMBL:AL589148) Streptomyces coelicolor esterase SCP1.199c%2C 505 aa%3B fasta scores: opt: 2894 z-score: 2571.4 E(): 0%3B 83.0%25 identity in 506 aa overlap. Contains Pfam match to entry PF00089 trypsin%2C Trypsin and possible N-terminal region signal peptide sequence. Also contains 2x degenerate repeat: NADGRxDxxAVxDDGSL(8x)GxL(3x)RxLWxDNTWxPM(3x)GGDFxxDGxGDxA AV(3x)GTLxLYTGTxTGxLNK gene gene6171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6109 SCO6110 SCO6110 SCBAC1A6.34c SCBAC1A6.34c 6713089 6714015 - sugar kinase SCBAC1A6.34c%2C probable sugar kinase%2C len: 308 aa%3B similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) Glk or SC6E10.20c%2C 317 aa%3B fasta scores: opt: 391 z-score: 407.0 E(): 4.3e-15%3B 34.4%25 identity in 314 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and match to Prosite entry PS01125 ROK family signature gene gene6172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6110 SCO6111 SCO6111 SCBAC1A6.35c SCBAC1A6.35c 6714012 6715769 - oligopeptide ABC transporter ATP-binding protein SCBAC1A6.35c%2C probable oligopeptide ABC transporter ATP-binding protein%2C len: 585 aa%3B similar to SW:YLIA_ECOLI (EMBL:AE000185) Escherichia coli hypothetical ABC transporter ATP-binding protein YliA%2C 629 aa%3B fasta scores: opt: 1480 z-score: 1352.7 E(): 0%3B 44.5%25 identity in 580 aa overlap and N- and C-terminal regions both similar to SW:OPPD_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport ATP-binding protein OppD%2C 358 aa%3B fasta scores: opt: 864 z-score: 796.4 E(): 0%3B 49.6%25 identity in 274 aa overlap. Contains 2x Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries 2x PS00017 ATP/GTP-binding site motif A (P-loop) and 2x PS00211 ABC transporters family signature gene gene6173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6111 SCO6112 SCO6112 SCBAC1A6.36c SCBAC1A6.36c 6715766 6716659 - oligopeptide ABC transporter integral membrane protein SCBAC1A6.36c%2C probable oligopeptide ABC transporter integral membrane protein%2C len: 297 aa%3B similar to SW:APPC_BACSU (EMBL:U20909) Bacillus subtilis oligopeptide transport system permease AppC%2C 303 aa%3B fasta scores: opt: 725 z-score: 842.9 E(): 0%3B 39.4%25 identity in 287 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions gene gene6174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6112 SCO6113 SCO6113 SCBAC1A6.37c SCBAC1A6.37c 6716656 6717615 - peptide ABC transporter integral membrane protein SCBAC33E8.01c%2C possible peptide ABC transporter integral membrane protein (fragment)%2C len: >47 aa. Similar to the N-terminal part of TR:Q9KGM9 (EMBL:AP001507) Bacillus halodurans oligopeptide ABC transporter (permease) BH0029%2C 314 aa%3B fasta scores: opt: 136 Z-score: 200.4 bits: 42.5 E(): 0.0014%3B 47.826%25 identity in 46 aa overlap~SCBAC1A6.37c%2C probable oligopeptide ABC transporter integral membrane protein (fragment)%2C len: >312 aa%3B similar to SW:APPB_BACSU (EMBL:U20909) Bacillus subtilis oligopeptide transport system permease AppB%2C 317 aa%3B fasta scores: opt: 763 z-score: 895.6 E(): 0%3B 37.0%25 identity in 311 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene6175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6113 SCO6114 SCO6114 SC9B2.01c SC9B2.01c 6717677 6719485 - peptide-binding transport protein SC9B2.01c%2C partial CDS%2C possible peptide binding /transport protein%2C len: 223aa%3B similar to many eg. SW:OPPA_BACSU oligopeptide-binding protein OppA from Bacillus subtilis (545 aa) fasta scores%3B opt: 117%2C z-score: 142.4%2C E(): 1.2%2C (25.9%25 identity in 139 aa overlap). Contains probable N-terminal signal sequence.~SCBAC33E8.02c%2C possible peptide-binding transport protein (fragment)%2C len: >411 aa. Similar to C-terminal region of TR:Q9K6T2 (EMBL:AP001519) Bacillus halodurans dipeptide ABC transporter (dipeptide-binding protein) BH3644%2C 557 aa%3B fasta scores: opt: 199 Z-score: 227.0 bits: 51.4 E(): 4.8e-05%3B 23.179%25 identity in 302 aa overlap. Contains 2x Pfam matches to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5 gene gene6176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6114 SCO6115 SCO6115 SC9B2.02 SC9B2.02 6719695 6720918 + transcriptional regulator SC9B2.02%2C possible ROK family transcriptional regulator%2C len: 407 aa%3B similar to many e.g. SW:XYLR_BACSU xylose repressor XylR from Bacillus subtilis (384 aa) fasta scores%3B opt: 470%2C z-score: 522.8%2C E(): 7.9e-22%2C (28.4%25 identity in 370 aa overlap). Contains Pfam match to entry PF00480 ROK%2C ROK family. Also contains a probable helix-turn-helix (+3.71 SD) at residues 32 to 53. gene gene6177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6115 SCO6116 SCO6116 SC9B2.03 SC9B2.03 6720968 6722509 + hypothetical protein SC9B2.03%2C conserved hypothetical protein%2C len: 513 aa%3B similar to TR:CAC49227 (EMBL:AL603645) Rhizobium meliloti conserved hypothetical protein SMB21161%2C 477 aa%3B fasta scores: opt: 1078 Z-score: 1182.9 E(): 2.9e-58%3B 40.678%25 identity in 472 aa overlap gene gene6178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6116 SCO6117 SCO6117 SC9B2.04 SC9B2.04 6722506 6723300 + hypothetical protein SC9B2.04%2C unknown%2C len: 264aa%3B similar to CUTC_ECOLI copper homeostasis protein of undefined function%2C CutC%2C from Escherichia coli (248 aa) fasta scores%3B opt: 446%2C z-score: 453.8%2C E(): 5.5e-18%2C (37.6%25 identity in 242 aa overlap) and YOJ7_CAEEL hypothetical protein from Caenorhabditis elegans (250 aa) fasta scores%3B opt: 394%2C z-score: 402.4%2C E(): 4e-15%2C (39.3%25 identity in 191 aa overlap). Contains possible N-terminal region signal sequence peptide. gene gene6179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6117 SCO6118 SCO6118 SC9B2.05 SC9B2.05 6723322 6724296 + AraC family transcription regulator SC9B2.05%2C possible AraC family transcriptional regulator%2C len: 324aa%3B similar to many eg. TR:O31249 (EMBL:AJ002316) AlkR%2C transcriptional regulator of alkane utilization in Acinetobacter sp. strain ADP1 (306 aa) fasta scores%3B opt: 390%2C z-score: 436.9%2C E(): 4.8e-17%2C (28.3%25 identity in 314 aa overlap). Contains PS00041 Bacterial regulatory proteins%2C araC family signature and Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. Also contains a probable helix-turn-helix (+3.45 SD) at residues 238 to 259. gene gene6180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6118 SCO6119 SCO6119 SC9B2.06 SC9B2.06 6724307 6724990 + AraC family transcription regulator SC9B2.06%2C possible AraC family transcriptional regulator%2C len: 227aa%3B similar to many eg. SW:YMCR_STRLA proposed transcriptional regulator from Streptomyces lavendulae (281 aa) fasta scores%3B opt: 860%2C z-score: 947.3%2C E(): 0%2C (60.2%25 identity in 231 aa overlap) and C-terminal similarity to SW:RHAS_ECOLI RhaS%2C L-rhamnose operon regulatory protein from Escherichia coli (278 aa) fasta scores%3B opt: 119%2C z-score: 140.2%2C E(): 1.6%2C (28.4%25 identity in 81 aa overlap). Contains PS00041 Bacterial regulatory proteins%2C araC family signature and Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. gene gene6181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6119 SCO6120 SCO6120 SC9B2.07 SC9B2.07 6725136 6725624 + hypothetical protein SC9B2.07%2C unknown%2C len: 162 aa%3B similar to TR:E1319700 (EMBL:AL031541) unknown ORF in IS117 from Streptomyces coelicolor (175 aa) fasta scores%3B opt: 267%2C z-score: 323.9%2C E(): 9.4e-11%2C (32.7%25 identity in 162 aa overlap). Also similar to SW:YM2_STRCO hypothetical protein in the mini-circle%2C a transposable element of Streptomyces coelicolor A3(2) (122 aa) fasta scores%3B opt: 217%2C z-score: 268.1%2C E(): 1.2e-07%2C (34.2%25 identity in 120 aa overlap). gene gene6182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6120 SCO6121 SCO6121 SC9B2.08c SC9B2.08c 6725692 6726270 - transcriptional regulator SC9B2.08c%2C possible transcriptional regulator%2C len: 192 aa%3B similar to many e.g. TR:O34892 (EMBL:AF027868) proposed transcriptional regulator from Bacillus subtilis (191 aa) fasta scores%3B opt: 168%2C z-score: 207.7%2C E(): 0.00028%2C (30.2%25 identity in 96 aa overlap) and SW:TER3_ECOLI tetracycline repressor protein class C from Escherichia coli (219 aa) fasta scores%3B opt: 149%2C z-score: 184.7%2C E(): 0.0053%2C (45.5%25 identity in 55 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains a probable helix-turn-helix (+4.23 SD) at residues 35..56 gene gene6183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6121 SCO6122 SCO6122 SC9B2.09 SC9B2.09 6726363 6726809 + hypothetical protein SC9B2.09%2C possible membrane protein%2C len: 192aa%3B similar to TR:O32455 (EMBL:D87924) the 5th gene in the polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca (153 aa) fasta scores%3B opt: 129%2C z-score: 175.5%2C E(): 0.017%2C (31.1%25 identity in 122 aa overlap) and to TR:Q9RDS5 (EMBL:AL136500) Streptomyces coelicolor membrane protein SC1G2.04c%2C 148 aa%3B fasta scores: opt: 727 Z-score: 852.7 E(): 7.3e-40%3B 75.510%25 identity in 147 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6122 SCO6123 SCO6123 SC9B2.10c SC9B2.10c 6726883 6727275 - quinone binding protein SC9B2.10c%2C possible quinone binding protein%2C len: 130aa%3B similar to TR:O05205 (EMBL:U92563) mitomycin-binding protein from Streptomyces lavendulae (130 aa) fasta scores%3B opt: 453%2C z-score: 551.3%2C E(): 2.1e-23%2C (49.6%25 identity in 129 aa overlap). gene gene6185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6123 SCO6124 SCO6124 SC9B2.11 SC9B2.11 6727703 6728032 + hypothetical protein SC9B2.11%2C unknown%2C len: 109 aa%3B has a short region of similarity to C-terminal region of SW:TRPD_MYCTU probable anthranilate phosphoribosyltransferase (370 aa) fasta scores%3B opt: 111%2C z-score: 142.1%2C E(): 1.3%2C (38.5%25 identity in 65 aa overlap). gene gene6186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6124 SCO6125 SCO6125 SC9B2.12 SC9B2.12 6728081 6728752 + membrane lipoprotein SC9B2.12%2C possible membrane lipoprotein%2C len: 219aa%3B Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene6187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6125 SCO6126 SCO6126 SC9B2.13c SC9B2.13c 6728774 6729088 - hypothetical protein SC9B2.13c%2C unknown%2C len: 104 aa gene gene6188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6126 SCO6127 SCO6127 SC9B2.14 SC9B2.14 6729231 6730739 + carboxylesterase SC9B2.14%2C probable carboxylesterase%2C len: 502aa%3B similar to many both prokaryotic and eukaryotic eg. SW:PCD_ARTOX phenylcarbamate hydrolase%2C Pcd%2C from Arthrobacter oxidans (493 aa) fasta scores%3B opt: 924%2C z-score: 897.3%2C E(): 0%2C (37.2%25 identity in 503 aa overlap). Contains PS00122 Carboxylesterases type-B serine active site and 2x Pfam match to entry PF00135 COesterase%2C Carboxylesterases. gene gene6189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6127 SCO6128 SCO6128 SC9B2.15c SC9B2.15c 6730693 6730926 - hypothetical protein SC9B2.15c%2C unknown%2C len: 77 aa%3B similar to three proteins of unknown function from Streptomyces coelicolor egs. TR:O86600 (EMBL:AL031514) (81 aa) fasta scores%3B opt: 283%2C z-score: 412.5%2C E(): 1.1e-15%2C (54.7%25 identity in 75 aa overlap) and TR:Q53896 (EMBL:X60316) ORFD from the AbaA locus (75 aa) fasta scores%3B opt: 117%2C z-score: 182.4%2C E(): 0.0071%2C (46.2%25 identity in 52 aa overlap). Contains a 2x20 residue degenerate direct repeat%2C WFKSSYSG*EGGNC*EVA*E. gene gene6190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6128 SCO6129 SCO6129 SC9B2.16c SC9B2.16c 6730923 6731834 - DNA-binding protein SC9B2.16c%2C possible DNA-binding protein%2C len: 303aa%3B similar to proteins of unknown function egs. TR:O86676 (EMBL:AL031371) hypothetical 30.7 kD protein from Streptomyces coelicolor (277 aa) fasta scores%3B opt: 552%2C z-score: 663.3%2C E(): 1.2e-29%2C (37.7%25 identity in 257 aa overlap) and SW:ENTD_SALTY EntD%2C a protein from Salmonella typhimurium with undefined involvement in enterobactin biosynthesis (232 aa) fasta scores%3B opt: 102%2C z-score: 129.9%2C E(): 6%2C (26.7%25 identity in 191 aa overlap). Contains a probable helix-turn-helix (+3.37 SD) at residues 60 to 81 gene gene6191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6129 SCO6130 SCO6130 SC9B2.17 SC9B2.17 6731917 6732270 + hypothetical protein SC9B2.17%2C unknown%2C len: 117 aa%3B similar to many proteins of undefined function some of which are proposed to be regulatory proteins (by similarity) eg. TR:Q53897 (EMBL:X60316) ORFA of the AbaA locus from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 255%2C z-score: 325.2%2C E(): 7.9e-11%2C (40.9%25 identity in 110 aa overlap) and TR:E1359165 (EMBL:AL034446) regulatory protein from Streptomyces coelicolor (135 aa) fasta scores%3B opt: 234%2C z-score: 301.8%2C E(): 1.6e-09%2C (43.0%25 identity in 121 aa overlap). gene gene6192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6130 SCO6131 SCO6131 SC9B2.18c SC9B2.18c 6732336 6733691 - carboxypeptidase SC9B2.18c%2C probable carboxypeptidase%2C len: 451aa%3B similar to SW:DAC_ACTSP D-alanyl-D-alanine carboxypeptidase precursor from Actinomadura sp. (strain R39) (538 aa) fasta scores%3B opt: 399%2C z-score: 430.8%2C E(): 1e-16%2C (30.9%25 identity in 512 aa overlap) and PBP4_ECOLI penicillin-binding protein 4 precursor (PBP-4) (D-alanyl-D-alanine carboxypeptidase) from Escherichia coli (477 aa) fasta scores%3B opt: 383%2C z-score: 414.4%2C E(): 8.6e-16%2C (29.4%25 identity in 445 aa overlap). Contains probable hydrophobic membrane spanning region gene gene6193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6131 SCO6132 SCO6132 SC9B2.19c SC9B2.19c 6733884 6734480 - hypothetical protein SC9B2.19c%2C possible integral membrane protein%2C len: 198 aa%3B contains several possible membrane spanning regions. gene gene6194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6132 SCO6133 SCO6133 SC9B2.20c SC9B2.20c 6734477 6735859 - hypothetical protein SC9B2.20c%2C membrane protein%2C len: 460 aa%3B similar to many eg. TR:O53313 (EMBL:AL021646) hypothetical protein from Mycobacterium tuberculosis (423 aa) fasta scores%3B opt: 666%2C z-score: 620.8%2C E(): 2.7e-27%2C (33.6%25 identity in 417 aa overlap). Contains possible membrane spanning hydrophobic region gene gene6195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6133 SCO6134 SCO6134 SC9B2.21c SC9B2.21c 6735856 6736854 - regulatory protein SC9B2.21c%2C possible regulatory protein%2C len: 332aa%3B similar to many proposed regulators and hypotheticals eg. TR:O53314 (EMBL:AL021646) regulatory protein from Mycobacterium tuberculosis (320 aa) fasta scores%3B opt: 1227%2C z-score: 1374.2%2C E(): 0%2C (60.3%25 identity in 302 aa overlap). gene gene6196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6134 SCO6135 SCO6135 SC9B2.22c SC9B2.22c 6736851 6737525 - hypothetical protein SC9B2.22c%2C membrane protein%2C len: 224 aa%3B similar to SW:Y00U_MYCTU hypothetical protein from Mycobacterium tuberculosis (250 aa) fasta scores%3B opt: 125%2C z-score: 145.6%2C E(): 0.8%2C (26.4%25 identity in 208 aa overlap). Contains 4x5 residue perfect direct repeat%2C QTSVA%2C in the N-terminal region. Contains possible hydrophobic membrane spanning regions gene gene6197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6135 SCO6136 SCO6136 SC9B2.23c SC9B2.23c 6737522 6738541 - transmembrane protein SC9B2.23c%2C possible transmembrane protein%2C unknown function%2C len: 339aa%3B similar to TR:O53316 (EMBL:AL021646) transmembrane protein from Mycobacterium tuberculosis (319 aa) fasta scores%3B opt: 247%2C z-score: 240.4%2C E(): 4.2e-06%2C (28.2%25 identity in 326 aa overlap). Contains 3 possible membrane spanning regions. gene gene6198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6136 SCO6137 SCO6137 mmuM mmuM 6738552 6739466 - homocysteine methyltransferase converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines gene gene6199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6137 SCO6138 SCO6138 SC1A9.02 SC1A9.02 6739546 6740469 + transmembrane protein SC1A9.02%2C possible transmembrane protein%2C len: 307aa%3B Contains several possible membrane spanning domains. gene gene6200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6138 SCO6139 SCO6139 SC1A9.03 SC1A9.03 6740466 6741632 + sensor kinase SC1A9.03%2C probable two component sensor kinase%2C len: 388aa%3B similar to a family of sensor kinases egs. TR:Q53893 (EMBL:U51332) AbsA1 from Streptomyces coelicolor (571 aa)%2C fasta scores%3B opt: 389%2C z-score: 278.9%2C E(): 2.9e-08%2C (33.1%25 identity in 405 aa overlap) and UHPB_ECOLI (EMBL:M17102) sensor kinase from Escherichia coli (500 aa)%2C fasta scores%3B opt:221%2C z-score: 248.0%2C E(): 1.5e-06%2C (25.9%25 identity in 398 aa overlap). Contains several possible membrane spanning domains. gene gene6201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6139 SCO6140 SCO6140 SC1A9.04 SC1A9.04 6741629 6742288 + two-component system response regulator SC1A9.04%2C probable luxR family two-component system response regulator%2C len: 219 aa%3B similar to a family of regulators egs. TR:O69816 (EMBL:AL023496) probable two-component regulator from Streptomyces coelicolor (224 aa) fasta scores%3B opt:714%2C z-score:1103.5%2C E():0%2C (54.8%25 identity in 219 aa overlap) and NARL_ECOLI (EMBL:X13360) nitrate /nitrite response regulator from Escherichia coli (216 aa) fasta scores%3B opt: 465%2C z-score: 656.5%2C E(): 2.7e-29%2C (37.6%25 identity in 213 aa overlap). Contains Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 111.10%2C E-value 2.1e-29%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 79.50%2C E-value 7e-20%2C PS00622 Bacterial regulatory proteins%2C luxR family signature and an helix-turn-helix motif from: 1 to: 219%2C Score 983 (+2.53 SD). gene gene6202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6140 SCO6141 SCO6141 SC1A9.05c SC1A9.05c 6742307 6742909 - transmembrane protein SC1A9.05c%2C possible transmembrane protein%2C len: 200 aa%3B contains possible membrane spanning hydrophobic regions gene gene6203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6141 SCO6142 SCO6142 SC1A9.06 SC1A9.06 6742955 6743446 + hypothetical protein SC1A9.06%2C unknown%2C len: 163 aa gene gene6204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6142 SCO6143 SCO6143 SC1A9.07 SC1A9.07 6743443 6744198 + hypothetical protein SC1A9.07%2C hypothetical protein%2C len: 251 aa%3B similar to TR:O33986 (EMBL:U82823) hypothetical protein from Saccharopolyspora erythraea (266 aa)%2C fasta scores%3B opt: 740%2C z-score: 869.0%2C E(): 0%2C (53.4%25 identity in 251 aa overlap) gene gene6205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6143 SCO6144 SCO6144 SC1A9.08c SC1A9.08c 6744201 6744770 - transcriptional regulator SC1A9.08c%2C possible transcriptional regulator%2C len: 189 aa%3B similar to TR:O34892 (EMBL:AF027868) proposed transcriptional regulator from Bacillus subtilis (191 aa) fasta scores%3B opt: 302%2C z-score: 488.2%2C E(): 6.6e-20%2C (31.8%25 identity in 173 aa overlap). Contains an helix-turn-helix motif from: 1 to: 189%2C Score 1074 (+2.84 SD). gene gene6206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6144 SCO6145 SCO6145 SC1A9.09 SC1A9.09 6744922 6746640 + hypothetical protein SC1A9.09%2C unknown%2C len: 572 aa%3B Contains His rich extreme N-terminal. gene gene6207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6145 SCO6146 SCO6146 SC1A9.10 SC1A9.10 6746637 6747161 + hypothetical protein SC1A9.10%2C unknown%2C len: 174 aa gene gene6208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6146 SCO6147 SCO6147 aldo aldo 6747192 6748448 - alditol oxidase Catalyses the selective oxidation of primary alcohols into the corresponding aldehydes. The enzyme preferably acts on alditols (e.g. xylitol%2C sorbitol%2C mannitol%2C threitol). The enzyme follows a ternary compelx mechanism. For xylitol the product is solely D-xylose. The enzyme contains a covalently linked FAD cofactor per enzyme molecule (the FAD cofactor is linked to His46). The enzyme is monomeric and belongs to the 'vanillyl-alcohol oxidase' family of flavoprotein (VAO-family). gene gene6209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6147 SCO6148 SCO6148 SC1A9.12 SC1A9.12 6748555 6749883 + hypothetical protein SC1A9.12%2C unknown%2C len: 442 aa gene gene6210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6148 SCO6149 SCO6149 SC1A9.13 SC1A9.13 6750131 6751231 + ribosome-associated GTPase EngC%3B RsgA%3B CpgA%3B circularly permuted GTPase%3B ribosome small subunit-dependent GTPase A%3B has the pattern G4-G1-G3 as opposed to other GTPases%3B interacts strongly with 30S ribosome which stimulates GTPase activity gene gene6211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6149 SCO6150 SCO6150 SC1A9.14 SC1A9.14 6751304 6752737 + ADA-like regulatory protein SC1A9.14%2C possible ADA-like regulatory protein%2C len: 477 aa%3B similar to ADA_MYCTU (EMBL:Z73902) ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores%3B opt: 1135%2C z-score: 1376.3%2C E(): 0%2C (51.6%25 identity in 486 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI (EMBL:M10211) ADA regulatory protein from Escherichia coli (354 aa) fasta scores%3B opt: 302%2C z-score: 255.8%2C E(): 5.7e-07%2C (34.5%25 identity in 171 aa overlap) and C-terminal region similar to 3MG2_ECOLI AlkA%2C 3-methyladenine DNA glycosylase II involved in DNA repair (282 aa) fasta scores%3B opt: 171%2C z-score: 232.9%2C E(): 1.1e-05%2C (30.0%25 identity in 290 aa overlap). Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C score 72.90%2C E-value 6.7e-18 and PS00041 Bacterial regulatory proteins%2C araC family signature. gene gene6212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6150 SCO6151 SCO6151 SC1A9.15 SC1A9.15 6752734 6753294 + methylated-DNA-protein-cysteine methyltransferase SC1A9.15%2C ogt%2C methylated-DNA-protein-cysteine methyltransferase len: 186 aa%3B similar to many eg. DAT1_BACSU (EMBL:X15659) methylated-DNA-protein-cysteine methyltransferase from Bacillus subtilis (165 aa) fasta scores%3B opt:357%2C z-score: 478.2%2C E(): 2.3e-19%2C (41.4%25 identity in 157 aa overlap). Contains Pfam match to entry PF01035 Methyltrans%2C 6-O-methylguanine DNA methyltransferase%2C score 170.70%2C E-value 2.5e-47. gene gene6213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6151 SCO6152 SCO6152 SC1A9.16c SC1A9.16c 6753257 6753739 - small hydrophobic protein membrane protein SC1A9.16c%2C small hydrophobic protein (membrane protein)%2C len: 160 aa. Contains possible hydrophobic membrane spanning regions gene gene6214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6152 SCO6153 SCO6153 SC1A9.17c SC1A9.17c 6753801 6754784 - regulatory protein SC1A9.17c%2C possible regulatory protein%2C len: 424 aa%3B similar to TR:Q56084 (EMBL:D63904) ESA36 protein of undefined function from Streptomyces thermoviolaceus (334 aa) fasta scores%3B opt: 313%2C z-score: 401.9%2C E(): 4.1e-15%2C (30.0%25 identity in 337 aa overlap). Also similar to SW:BRPA_STRHY bialaphos biosynthetic pathway regulatory protein from Streptomyces hygroscopicus (256 aa)%2C fasta scores%3B opt: 234%2C z-score: 233.8%2C E(): 9.5e-06%2C (30.1%25 identity in 163 aa overlap). Contains helix-turn-helix motif from: 1 to: 424%2C Score 1064 (+2.81 SD). Possible coiled-coil from 171 to 200 (30 residues) Max score: 1.447 (probability 0.87) gene gene6215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6153 SCO6154 SCO6154 SC1A9.18 SC1A9.18 6755707 6756879 + hypothetical protein SC1A9.18%2C unknown%2C len: 390 aa gene gene6216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6154 SCO6155 SCO6155 SC1A9.19 SC1A9.19 6756908 6758650 + pyruvate dehydrogenase catalyzes the formation of acetate from pyruvate gene gene6217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6155 SCO6156 SCO6156 SC1A9.20 SC1A9.20 6758794 6759201 + regulatory protein SC1A9.20%2C possible regulatory protein%2C len: 135aa%3B similar to TR:O69204 (EMBL:U33059) hypothetical protein from Amycolatopsis mediterranei S699 (144 aa) fasta scores%3B opt:225%2C z-score:335.1. E(): 2.2e-11%2C (41.7%25 identity in 115 aa overlap). Also similar to TR:Q53897 (EMBL:X60316) AbaA regulatory locus for antibiotic production in Streptomyces coelicolor (192 aa)%2C fasta scores%3B opt: 155%2C z-score: 284.6%2C E(): 1.4e-08%2C (33.3%25 identity in 120 aa overlap) gene gene6218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6156 SCO6157 SCO6157 SC1A9.21c SC1A9.21c 6759259 6760323 - transmembrane protein SC1A9.21c%2C possible transmembrane protein%2C len: 354 aa%3B contains possible membrane spanning hydrophobic domains in the N-terminal region and possible coiled-coil from 221 to 250 (30 residues) Max score: 1.449 (probability 0.87) gene gene6219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6157 SCO6158 SCO6158 SC1A9.22c SC1A9.22c 6760581 6761426 - hypothetical protein SC1A9.22c%2C unknown%2C len: 281 aa gene gene6220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6158 SCO6159 SCO6159 SC1A9.23 SC1A9.23 6761595 6762416 + GntR family transcriptional regulator SC1A9.23%2C possible gntR family transcriptional regulator%2C len: 273 aa%3B similar to TR:O69996 (EMBL:AL022374) WhiH%2C sporulation transcription factor from Streptomyces coelicolor (295 aa) fasta scores%3B opt: 139%2C z-score: 267.9%2C E(): 1.2e-07%2C (29.8%25 identity in 292 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family%2C score 30.50%2C E-value 7.1e-08. gene gene6221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6159 SCO6160 SCO6160 SC1A9.24c SC1A9.24c 6762662 6765049 - bifunctional preprotein translocase subunit SecD/SecF part of the preprotein secretory system%3B forms a complex with protein YajC%3B SecDFyajC stimulates the proton motive force-driven protein translocation%2C seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane%3B in some organisms%2C such as Bacillus subtilis%2C SecD is fused to SecF gene gene6222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6160 SCO6161 SCO6161 SC1A9.25c SC1A9.25c 6765129 6765518 - hypothetical protein SC1A9.25c%2C probable hypothetical protein%2C len: 129 aa%3B Contains a strong N-terminal signal sequence gene gene6223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6161 SCO6162 SCO6162 SC1A9.26c SC1A9.26c 6765623 6766405 - two-component system response regulator SC1A9.26c%2C probable luxR family two-component system response regulator%2C len: 260aa%3B similar to a family of response regulators eg. TR:O69961 (EMBL:AL022268) probable two-component transcriptional regulator from Streptomyces coelicolor (219 aa) fasta scores%3B opt:1079%2C z-score: 1434.4%2C E():0%2C (77.5%25 identity in 218 aa overlap) and DEGU_BACBR (EMBL:L15444) transcriptional activator protein DegU from Bacillus brevis (236 aa) fasta scores%3B opt:378%2C z-score: 682.5%2C E(): 9.7e-31%2C (36.6%25 identity in 227 aa overlap). Contains PS00622 Bacterial regulatory proteins%2C luxR family signature%2C Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 99.70%2C E-value 5.6e-26%2C Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 132.90%2C E-value 5.6e-36 and an helix-turn-helix motif from: 1 to: 260%2C Score 1221 (+3.35 SD). gene gene6224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6162 SCO6163 SCO6163 SC1A9.27c SC1A9.27c 6766414 6767325 - sensor kinase SC1A9.27c%2C probable sensor kinase%2C len: 303aa%3B similar to a family of sensor kinases eg. TR:O69960 (EMBL:AL022268) probable two-component sensor protein from Streptomyces coelicolor (358 aa) fasta scores%3B opt:1037%2C z-score: 1477.8%2C E():0%2C (59.2%25 identity in 299 aa overlap) and TR:Q52558 (EMBL:U02041) two-component sensor regulating virulence genes of Pseudomonas solanacearum (502 aa) fasta scores%3B opt: 388%2C z-score: 475.5%2C E():3.3e-19%2C (31.5%25 identity in 270 aa overlap). Contains possible hydrophobic membrane spanning regions gene gene6225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6163 SCO6164 SCO6164 SC1A9.28c SC1A9.28c 6767705 6768031 + hypothetical protein SC1A9.28c%2C unknown%2C len: 192aa%3B some similarity to TR:O66611 (EMBL:AE000680) protein from Aquifex aeolicus (145 aa) fasta scores%3B opt: 188%2C z-score: 294.0%2C E():4.4e-09%2C (36.6%25 identity in 93 aa overlap) gene gene6226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6164 SCO6165 SCO6165 SC1A9.29c SC1A9.29c 6768101 6768478 + hypothetical protein SC6C5.01%2C partial CDS%2C unknown%2C len: 121aa%3B similar to TR:O83134 (EMBL:AE001194) dnaK suppressor from Treponema pallidum (120 aa) fasta scores%3B opt: 162%2C z-score: 252.5%2C E(): 8.9e-07%2C (40.7%25 identity in 59 aa overlap).~SC1A9.29c%2C partial CDS%2C unknown%2C len: 38aa gene gene6227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6165 SCO6166 SCO6166 SC6C5.02 SC6C5.02 6768481 6769299 + hypothetical protein SC6C5.02%2C unknown%2C len: 272aa gene gene6228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6166 SCO6167 SCO6167 SC6C5.03 SC6C5.03 6769408 6770778 + proline rich protein membrane protein SC6C5.03%2C proline rich protein (membrane protein)%2C len: 456 aa. Contains possible hydrophobic membrane spanning regions gene gene6229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6167 SCO6168 SCO6168 SC6C5.04c SC6C5.04c 6770801 6771589 - hypothetical protein SC6C5.04c%2C unknown%2C len: 262aa gene gene6230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6168 SCO6169 SCO6169 SC6C5.05c SC6C5.05c 6771761 6773470 - regulatory protein SC6C5.05c%2C possible regulatory protein%2C len: 569aa%3B C-terminal similarity to TR:Q00509 (EMBL:X63451) SrmR protein from Streptomyces ambofaciens (604 aa) fasta scores%3B opt: 203%2C z-score: 206.9%2C E(): 0.00031%2C (30.0%25 identity in 207 aa overlap). Contains helix-turn-helix motif from 523 to 544 (+2.73 SD). gene gene6231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6169 SCO6170 SCO6170 SC6C5.06 SC6C5.06 6773787 6774677 + oxidoreductase subunit SC6C5.06%2C probable oxidoreductase subunit%2C len: 296aa%3B similar to many%2C both prokaryotic and eukaryotic egs. TR:Q59127 (EMBL:X75338) nicotine dehydrogenase from Arthrobacter nicotinovorans (283 aa) fasta scores%3B opt: 308%2C z-score: 490.8%2C E(): 4.8e-20%2C (29.9%25 identity in 281 aa overlap) and SW:XDH_DROPS xanthine dehydrogenase from Drosophila pseudoobscura (1342 aa) fasta scores%3B opt: 146%2C z-score: 404.4%2C E(): 3.1e-15%2C (31.3%25 identity in 240 aa overlap). Contains Pfam match to entry PF00941 dehydrog_molyb%2C Molybdopterin binding domain in dehydrogenase%2C score 41.00%2C E-value 1.2e-12. gene gene6232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6170 SCO6171 SCO6171 SC6C5.07 SC6C5.07 6774677 6775267 + oxidoreductase SC6C5.07%2C probable iron-sulphur binding oxidoreductase subunit%2C len: 196aa%3B similar to many eg. TR:P95635 (EMBL:U65440) 4-hydroxybenzoyl-CoA reductase from Rhodopseudomonas palustris (163 aa) fasta scores%3B opt: 288%2C z-score: 720.8%2C E(): 7.4e-33%2C (42.2%25 identity in 187 aa overlap) and TR:P72223 (EMBL:X98131) quinoline 2-oxidoreductase from Pseudomonas putida (168 aa) fasta scores%3B opt: 264%2C z-score: 703.7%2C E(): 6.6e-32%2C (40.4%25 identity in 198 aa overlap). Contains PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature. gene gene6233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6171 SCO6172 SCO6172 SC6C5.08 SC6C5.08 6775270 6777756 + oxidoreductase SC6C5.08%2C probable oxidoreductase subunit%2C len: 828aa%3B similar to many eg. TR:O32144 (EMBL:Z99120) Yurc protein from Bacillus subtilis (745 aa) fasta scores%3B opt: 626%2C z-score: 1140.2%2C E(): 0%2C (33.1%25 identity in 773 aa overlap) and SW:MOP_DESGI aldehyde oxidoreductase Desulfovibrio gigas (907 aa) fasta scores%3B opt: 538%2C z-score: 893.1%2C E(): 0%2C (29.5%25 identity in 791 aa overlap). Contains Pfam match to entry PF01315 Ald_Xan_dh_C%2C Aldehyde oxidase and xanthine dehydrogenase%2C C terminus%2C score 497.50%2C E-value 1e-145. gene gene6234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6172 SCO6173 SCO6173 SC6C5.09 SC6C5.09 6777908 6779365 + permease SC6C509 SC6C5.09%2C probable permease%2C len: 485aa%3B similar to many eg. SW:Y326_METJA hypothetical protein from Methanococcus jannaschii (436 aa) fasta scores%3B opt: 517%2C z-score: 1019.3%2C E(): 0%2C (37.2%25 identity in 454 aa overlap). Contains Pfam match to entry PF00860 xan_ur_permease%2C Xanthine /uracil permeases family%2C score 43.50%2C E-value 4.9e-09. gene gene6235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6173 SCO6174 SCO6174 SC6C5.10 SC6C5.10 6779417 6780604 + hypothetical protein SC6C5.10%2C conserved hypothetical protein%2C len: 395 aa%3B similar to many eg. TR:O53711 (EMBL:AL021931) hypothetical protein from Mycobacterium tuberculosis (380 aa) fasta scores%3B opt: 1247%2C z-score: 1422.8%2C E(): 0%2C (56.7%25 identity in 372 aa overlap). gene gene6236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6174 SCO6175 SCO6175 SC6C5.11 SC6C5.11 6780609 6781592 + hypothetical protein SC6C5.11%2C hypothetical protein%2C len: 327 aa%3B similar to TR:Q9LAB8 (EMBL:AF144381) Burkholderia gladioli esterase EstC%2C 298 aa%3B fasta scores: opt: 532 Z-score: 590.8 E(): 2.8e-25%3B 38.014%25 identity in 292 aa overlap gene gene6237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6175 SCO6176 SCO6176 SC6C5.12c SC6C5.12c 6781601 6782431 - hypothetical protein SC6C5.12c%2C hypothetical protein%2C len: 327 aa%3B similar to TR:Q9S1Z5 (EMBL:AL109747) Streptomyces coelicolor hypothetical protein SCJ21.12c%2C 279 aa%3B fasta scores: opt: 474 Z-score: 525.2 E(): 1.3e-21%3B 41.007%25 identity in 278 aa overlap gene gene6238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6176 SCO6177 SCO6177 SC6C5.13c SC6C5.13c 6782568 6783008 - hypothetical protein SC6C5.13c%2C unknown%2C len: 327aa gene gene6239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6177 SCO6178 SCO6178 SC6C5.14c SC6C5.14c 6783029 6783811 - deacetylase SC6C5.14c%2C possible deacetylase (hypothetical protein)%2C len: 260 aa%3B similar to many e.g. SW:NODB_RHILT NodB%2C chitooligosaccharide deacetylase%2C nodulation protein B%2C from Rhizobium leguminosarum (215 aa) fasta scores%3B opt: 321%2C z-score: 420.9%2C E(): 3.7e-16%2C (35.0%25 identity in 197 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene6240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6178 SCO6179 SCO6179 SC6C5.15 SC6C5.15 6783983 6784975 + nucleotide-sugar dehydratase SC6C5.15%2C probable nucleotide-sugar dehydratase%2C len: 330 aa%3B similar to many e.g. TR:Q54144 (EMBL:U08223) dTDP-glucose dehydratase from Streptomyces fradiae (333 aa) fasta scores%3B opt: 581%2C z-score: 563.5%2C E(): 4.3e-24%2C (38.4%25 identity in 318 aa overlap). gene gene6241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6179 SCO6180 SCO6180 SC2G5.01 SC2G5.01 6785096 6786736 + transferase SC2G5.01%2C partial CDS%2C possible transferase%2C len:>187aa%3B constitutes the C-terminal end of SC6C5.16 (EMBL:AL034 492) from Streptomyces coelicolor. Similar to the C-terminal region of many egs. SW:CMCH_NOCLA3'-hydroxymethylcephem- O-carbamoyltransferase%2C a protein involved in cephamycin synthesis in Nocardia lactamdurans(520 aa) fasta scores%3B opt : 373%2C z-score: 451.4%2C E():7.4e-18%2C (40.1%25 identity in 167 aa overlap).~SC6C5.16%2C partial CDS%2C unknown%2C len: 392aa%3B similar to many eg. SW:NOLO_RHISN nodulation associated protein NolNO from Rhizobium sp. (strain NGR234) (680 aa) fasta scores%3B opt: 696%2C z-score: 849.5%2C E(): 0%2C (36.7%25 identity in 403 aa overlap). gene gene6242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6180 SCO6181 SCO6181 SC2G5.02 SC2G5.02 6786733 6787767 + transferase SC2G5.02%2C possible transferase%2C len: 344aa%3B similar to many eg. SW:EXOO_RHIME succinoglycan biosynthesis protein%2C ExoO%2C from Rhizobium meliloti (334 aa) fasta scores%3B opt:177%2C z-score: 202.6%2C E(): 0.00053%2C (29.5%25 identity in 278aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases%2C score 32.70%2CE-value 8.3e-06. gene gene6243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6181 SCO6182 SCO6182 SC2G5.03 SC2G5.03 6787764 6788621 + dehydratase SC2G5.03%2C possible dehydratase%2C len: 285aa%3B N-terminal region similar to SW:HIS7_SALTY%2C HisB%2C imidazoleglycerol-phosphate dehydratase (354 aa) from Salmonella typhimurium fasta scores%3B opt: 207%2C z-score:191.1%2C E(): 0.0023%2C (29.4 %25identity in 143 aa overlap). Also similar TR:Q54364 (EMBL:X79146) located within thelincomycin-production gene cluster of Streptomyces lincolnensis 78-11 (190 aa) fasta scores opt: 345%2C z-score:312.0%2C E(): 4.3e-10%2C (40.5%25 identity in 185 aa overlap). gene gene6244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6182 SCO6183 SCO6183 SC2G5.04 SC2G5.04 6788618 6789625 + transferase SC2G5.04%2C possible transferase%2C len: 335aa%3B similar to many eg. TR:O05195 (EMBL:U70982) heptosyl transferase I from Pseudomonas aeruginosa (355 aa) a protein known to be involved in the synthesis of lipopolysaccharide%2C fasta scores%3B opt: 240%2C z-score: 250.8%2C E(): 1.1e-06%2C (29.3%25 identity in 324aa overlap). Contains Pfam match to entry PF01075 Heptosyltranf%2C Heptosyl transferase%2C score 35.10%2CE-value7.1e-09. gene gene6245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6183 SCO6184 SCO6184 SC2G5.05 SC2G5.05 6789622 6790572 + transferase SC2G5.05%2C possible transferase%2C len: 312aa%2C C-terminal region similar to C-terminal from many eg. TR:Q47594 (EMBL:D43637) mannosyl transferase B from Escherichia coli fasta scores%3B opt: 149%2C z-score: 178.9%2C E(): 0.011%2C (32.0%25 identity in 150 aa overlap). gene gene6246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6184 SCO6185 SCO6185 SC2G5.06 SC2G5.06 6790569 6791789 + transferase SC2G5.06%2C possible transferase%2C len: 402aa%3B similar to many egs. SW:YV12_MYCTU hypothetical protein from Mycobacterium tuberculosis (480 aa) fasta scores%3B opt: 652%2C z-score: 737.4%2C E(): 0%2C (34.6%25 identity in 408 aa overlap) and TR:O84909 (EMBL:AF010182) glycosyl transferase%2C WbpY from Pseudomonas aeruginosa (371 aa) fasta scores%3B opt: 298%2C z-score: 340.5%2C E(): 1.1e-11%2C (29.4%25 identity in 326 aa overlap). Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1%2C score 111.00%2C E-value 1.2e-30. gene gene6247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6185 SCO6186 SCO6186 SC2G5.07 SC2G5.07 6791786 6792481 + phosphoheptose isomerase SC2G5.07%2C probable phosphoheptose isomerase%2C len: 229aa%3B similar to TR:O25528 (EMBL:AE000596) phosphoheptose isomerase from Helicobacter pylori (192 aa) fasta scores%3B opt: 431%2C z-score: 495.6%2C E(): 2.6e-20%2C (46.9%25 identity in 147 aa overlap) and SW:LPCA_ECOLI phosphoheptose isomerase from Escherichia coli (192 aa) fasta scores%3B opt: 408%2C z-score: 469.8%2C E(): 7e-19%2C (41.6%25 identity in 161 aa overlap). Contains Pfam match to entry PF01380 SIS (Sugar ISomerase)%2C SIS domain%2C score 52.70%2C E-value 7.9e-12. gene gene6248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6186 SCO6187 SCO6187 SC2G5.08 SC2G5.08 6792478 6793869 + bifunctional synthase/transferase SC2G5.08%2C possible bifunctional synthase/transferase%2C len: 495aa%3B N-terminal region similar to many eg. TR:Q48046 (EMBL:U17642) ADP-heptose synthase from Haemophilus influenzae (342 aa) fasta scores%3B opt: 301%2C z-score: 304.7%2CE() : 1.1e-09%2C (29.3%25 identity in 311 aa overlap). C-terminal region simlar to TR:O28854 (EMBL:AE001006) glycerol-3-phosphate cytidyl transferase from Archaeoglobus fulgidus (137 aa) fasta scores%3B opt: 220%2C z-score: 230.3%2CE(): 1.5e-05%2C (42.2 %25 identity in 90 aa overlap). gene gene6249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6187 SCO6188 SCO6188 SC2G5.09 SC2G5.09 6793866 6795566 + transferase SC2G5.09%2C possible transferase%2C len: 566aa%3B C-terminal region similar to SW:RFAC_SALTY lipopolysaccharide heptosyltransferase-1 (317aa) blast scores%3B Sum P(2)%3D 1.3e-09%2C Identities%3D 46 /150 (30%25)%2C Positives %3D 70 /150 (46%25). gene gene6250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6188 SCO6189 SCO6189 SC2G5.10 SC2G5.10 6795563 6796516 + transferase SC2G5.10%2C possible transferase%2C len: 317aa%3B similar to many eg. SW:EXOU_RHIME succinoglycan biosynthesis protein%2C ExoU from Rhizobium meliloti (342 aa) fasta scores%3B opt:203%2C z-score: 234.7%2C E(): 8.7e-06%2C (30.3%25 identity in 274aa overlap). Pfam match to entry PF00535 Glycos_transf_2%2CGlycosyl transferases%2C score 37.70%2C E-value 2.6e-07. NB this CDS is an imperfect duplicate of the neighbouring downstream CDS SC2G5.11 fasta scores%3B opt: 772%2C z-score: 700.7%2C E():3.3e-34%2C (47.5%25 identity in 280 aa overlap). gene gene6251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6189 SCO6190 SCO6190 SC2G5.11 SC2G5.11 6796513 6797409 + transferase SC2G5.11%2C possible transferase%2C len: 298aa%3B similar to many eg. TR:P74820 (EMBL:U51197) glycosyl transferase from Sphingomonas S88 (288 aa) fasta scores%3B opt: 167%2C z-score: 204.0%2C E(): 0.00045%2C (27.5%25 identity in 262 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2%2CGlycosyl transferases%2C score 51.10%2C E-value 2.4e-11. NB this CDS is an imperfect duplicate of the neighbouring upstream CDS SC2G5.10 fasta scores%3B opt: 772%2C z-score: 804.0%2C E(): 0%2C (47.5%25 identity in 280 aa overlap). gene gene6252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6190 SCO6191 SCO6191 SC2G5.12c SC2G5.12c 6797459 6798373 - hypothetical protein SC2G5.12c%2C unknown%2C len: 304aa gene gene6253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6191 SCO6192 SCO6192 SC2G5.13 SC2G5.13 6798812 6799918 + hypothetical protein SC2G5.13%2C hypothetical protein%2C len: 304 aa%3B similar to TR:Q9KZ00 (EMBL:AL355753) Streptomyces coelicolor hypothetical protein SC8G12.05%2C 366 aa%3B fasta scores: opt: 688 Z-score: 744.6 E(): 7.7e-34%3B 44.110%25 identity in 365 aa overlap gene gene6254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6192 SCO6193 SCO6193 SC2G5.14c SC2G5.14c 6800241 6803072 - transcriptional regulator SC2G5.14c%2C possible transcriptional regulator%2C len: 943 aa%3B similar to TR:O05478 (EMBL:M86351) LipA transcriptional activator from Streptomyces sp. M11 (934aa) fasta scores%3B opt: 387%2C z-score: 377.7%2C E(): 9.5e-14%2C(31.1%25 identity in 875 aa overlap). Contains PS00622 Bacterial regulatory proteins%2C luxR family signature and PS00017 ATP /GTP-binding site motif A (P-loop). Also contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score53.30%2C E-value 5.3e-12. gene gene6255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6193 SCO6194 SCO6194 SC2G5.15c SC2G5.15c 6803232 6804071 - response regulator SC2G5.15c%2C possible response regulator%2C len:279aa%3B similar to many eg. TR:P72471 (EMBL:U63847) response regulator homolog from Streptomyces lividans (225aa) fasta scores%3B opt: 184%2C z-score: 203.6%2C E():0.00047%2C (32.7%25 identity in 208 aa overlap). Also C-terminal region similar to TR:P72402 (EMBL:Y07902) transcriptional regulator%2C RedZ (217 aa) fasta scores%3B opt:179%2C z-score:198.6%2C E():0.00089%2C (47.6 %25 identity in 63 aa overlap). Contains Pfam match to en try PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 58.30%2C E-value 1.7e-13. Contains possible helix-turn-helix at 234-255aa Score 1690 (+4.94 SD). gene gene6256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6194 SCO6195 SCO6195 SC2G5.16 SC2G5.16 6804196 6805872 + acetyl-coenzyme A synthetase SC2G5.16%2C probable acetyl-coenzyme A synthetase%2C len:558 aa%3B similar to many e.g. SW:ACSA_BACSU from Bacillus subtilis (572 aa) fasta scores%3B opt: 798%2C z-score: 878.3%2CE():0%2C (31.8%25 identity in 537 aa overlap). Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme%2C score 116.90%2C E-value 3.8e-31. Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme%2C score 116.90%2C E-value 3.8e-31 gene gene6257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6195 SCO6196 SCO6196 SC2G5.17 SC2G5.17 6805869 6807494 + AMP-binding domain-containing protein activates fatty acids by binding to coenzyme A gene gene6258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6196 SCO6197 SCO6197 SC2G5.18c SC2G5.18c 6807680 6808222 - hypothetical protein SC2G5.18c%2C possible hypothetical protein%2C len: 180 aa%3B similar to TR:O87846 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (168 aa) fasta scores%3B opt:476%2C z-score: 556.4%2C E(): 1e-23%2C (45.3%25 identity in 170 aa overlap). Contains possible N-terminal signal sequence gene gene6259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6197 SCO6198 SCO6198 SC2G5.19 SC2G5.19 6808799 6812269 + hypothetical protein SC2G5.19%2C possible hypothetical protein%2C len: 1156aa%3B alanine rich%2C similar to TR:O87848 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (1147 aa) fasta scores%3B opt: 2516%2C z-score: 2119.1%2C E(): 0%2C (44.6%25 identity in 1122 aa overlap). Contains possible N-terminal signal sequence. gene gene6260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6198 SCO6199 SCO6199 SC2G5.20 SC2G5.20 6812417 6814648 + esterase SC2G5.20%2C possible esterase%2C len: 743aa%3B similar to TR:Q54345 (EMBL:Z50108) esterase%2C FusH (509 aa) from Streptomyces lividans fasta scores%3B opt: 619%2C z-score: 601.5%2C E(): 3.2e-26%2C(40.9%25 identity in 389 aa overlap). Note that the CDS contains Pfam match to entry PF00089 trypsin%2CTrypsin%2C score 1.40%2C E-value 5.6e-05. Also contains possible N-terminal signal sequence. gene gene6261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6199 SCO6200 SCO6200 SC2G5.21c SC2G5.21c 6814657 6815349 - hypothetical protein SC2G5.21c%2C unknown%2C len: 230aa gene gene6262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6200 SCO6201 SCO6201 SC2G5.22 SC2G5.22 6815497 6817281 + glyoxylate carboligase catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate gene gene6263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6201 SCO6202 SCO6202 SC2G5.23c SC2G5.23c 6817450 6818094 - hypothetical protein SC2G5.23c%2C unknown%2C len: 214aa gene gene6264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6202 SCO6203 SCO6203 SC2G5.24c SC2G5.24c 6818162 6818500 - hypothetical protein SC2G5.24c%2C unknown%2C len: 112aa gene gene6265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6203 SCO6204 SCO6204 SC2G5.25c SC2G5.25c 6818863 6820326 - catalase SC2G5.25c%2C probable catalase%2C len: 487 aa%3B similar to many%2C most similar to SW:BCA_STRVL bromoperoxidase-catalase from Streptomyces violaceus (483 aa) fasta scores%3B opt: 2334%2Cz-score: 2595.9%2C E(): 0%2C (69.4%25 identity in 487 aaoverlap).Contains PS00437 and PS00438 Catalase proximal heme-ligand signatures. Also contains Pfam match to entry PF00199 catalase%2C Catalase%2C score 1008.70%2C E-value 1.3e-299. gene gene6266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6204 SCO6205 SCO6205 SC2G5.26c SC2G5.26c 6820531 6821421 - 2-hydroxy-3-oxopropionate reductase SC2G5.26c%2C probable dehydrogenase%2C len: 296aa%3B similar to many eg. TR:D1035162 (EMBL:AB015439) D-threonine dehydrogenase (292 aa) fasta scores%3B opt: 628%2C z-score:702.7%2C E(): 7.4e-32%2C (37.6%25 identity in 290 aa overlap). gene gene6267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6205 SCO6206 SCO6206 SC2G5.27c SC2G5.27c 6821469 6822308 - oxidoreductase SC2G5.27c%2C possible oxidoreductase%2C len: 279 aa%3B similar to many%2C mostly hypotheticals including TR:O50580 (EMBL :AB000361) D-tagatose 3-epimerase from Pseudomonas cichorii (290 aa) fasta scores%3B opt: 164%2C z-score:193.0%2CE(): 0.0018 %2C(26.8%25 identity in 142 aa overlap). Most similar to SW:GIP_ECOLI glyoxylate-induced protein from Escherichia coli (258 aa) fasta scores%3B opt: 411%2C z-score:473.6%2C E(): 4.3e-19%2C (35.0%25 identity in 266 aa overlap). As with the Escherichia coli homologue%2C this CDS is located close to the CDS for gcl (SC2G5.22). gene gene6268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6206 SCO6207 SCO6207 SC2G5.28 SC2G5.28 6822463 6822717 + hypothetical protein SC2G5.28%2C unknown%2C len: 84aa gene gene6269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6207 SCO6208 SCO6208 SC2G5.29 SC2G5.29 6822714 6823082 + DNA-binding protein SC2G5.29%2C possible DNA-binding protein%2C len: 122 aa%2C contains probable helix-turn-helix at 97-118aa Score 1428(+4.05 SD). gene gene6270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6208 SCO6209 SCO6209 SC2G5.30 SC2G5.30 6823172 6823747 + OHCU decarboxylase SC2G5.30%2C unknown%2C len: 191 aa%3B limited similarity to TR:O32141 (EMBL:Z99120) hypothetical protein from Bacillus subtilis (494 aa) fasta scores%3B opt: 204%2C z-score: 241.2%2CE(): 3.8e-06%2C (27.8%25 identity in 162 aa overlap). gene gene6271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6209 SCO6210 SCO6210 SC2G5.31 SC2G5.31 6823744 6824145 + hypothetical protein SC2G5.31%2C unknown%2C len: 133 aa%3B probably member of a family of transthyretin-like proteins%2C similar to many eg. SW:YEDX_ECOLI hypothetical transthyretin-like protein fromEscherichia coli (137 aa) fasta scores%3B opt: 149%2C z-score:198.9%2C E(): 0.00086%2C (40.9%25 identity in 127 aa overlap). gene gene6272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6210 SCO6211 SCO6211 SC2G5.32 SC2G5.32 6824153 6825088 + uricase SC9G1.01%2C possible uricase (partial CDS)%2C len: >204 aa%3B similar to SW:URIC_ASPFL (EMBL:X61766) Aspergillus flavus uricase (EC 1.7.3.3) (urate oxidase)%2C Uaz or Uox%2C 301 aa%3B fasta scores: opt: 49 z-score: 553.3 E(): 1.9e-23%3B 41.2%25 identity in 177 aa overlap. Contains Pfam match to entry PF01014 Uricase%2C Uricase~SC2G5.32%2C partial CDS%2C possible oxidoreductase%2C len: 141 aa%3B similar to the N-terminal region of many urate oxidases%2C a eukaryotic peroxisomal enzyme%2C e.g. SW:URIC_PAPHA urate oxidases from Papio hamadryas (Hamadryas baboon) (303 aa) fasta scores%3B opt: 282%2Cz-score: 368.8%2C E(): 3e-13%2C (36.6%25 identity in 131 aaoverlap). gene gene6273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6211 SCO6212 SCO6212 SC9G1.02 SC9G1.02 6825153 6826568 + permease SC9G1.02%2C possible permease%2C len: 471 aa%3B similar to SW:PBUX_BACSU (EMBL:X83878) Bacillus subtilis xanthine permease PubX%2C 438 aa%3B fasta scores: opt: 1060 z-score: 1156.8 E(): 0%3B 39.2%25 identity in 413 aa overlap to SW:URAA_ECOLI (EMBL:X73586) Escherichia coli uracil permease (uracil transporter) UraA%2C 429 aa%3B fasta scores: opt: 505 z-score: 554.2 E(): 1.7e-23%3B 28.9%25 identity in 422 aa overlap and to Streptomyces coelicolor St9G1.04%2C 462 aa%3B fasta scores: opt: 1668 z-score: 1511.0 E(): 0%3B 57.0%25 identity in 435 aa overlap. Contains match to Pfam entry Pfam match to entry PF00860 xan_ur_permease%2C Xanthine/uracil permeases family and match to Prosite entry PS01116 Xanthine/uracil permeases family signature gene gene6274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6212 SCO6213 SCO6213 SC9G1.03 SC9G1.03 6826642 6828039 + 8-oxoguanine deaminase catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. gene gene6275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6213 SCO6214 SCO6214 SC9G1.04 SC9G1.04 6828295 6829683 + permease SC9G1.04%2C probable permease%2C len: 462 aa%3B similar to SW:PBUX_BACSU (EMBL:X83878) Bacillus subtilis xanthine permease PubX%2C 438 aa%3B fasta scores: opt: 1088 z-score: 1244.0 E(): 0%3B 41.5%25 identity in 417 aa overlap and to Streptomyces coelicolor St9G1.02%2C 471 aa%3B fasta scores: opt: 1668 z-score: 1651.2 E(): 0%3B 57.0%25 identity in 435 aa overlap. Contains match to Pfam entry Pfam match to entry PF00860 xan_ur_permease%2C Xanthine/uracil permeases family and match to Prosite entry PS01116 Xanthine/uracil permeases family signature gene gene6276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6214 SCO6215 SCO6215 SC9G1.05 SC9G1.05 6830017 6830142 + hypothetical protein SC9G1.05%2C unknown%2C len: 41 aa gene gene6277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6215 SCO6216 SCO6216 SC9G1.06c SC9G1.06c 6830158 6830580 - hypothetical protein SC9G1.06c%2C hypothetical protein%2C len: 140 aa%3B similar to SW:YBAW_ECOLI (EMBL%3BAE000150) Escherichia coli hypothetical 15.1 KD protein%2C 132 aa%3B fasta scores: opt: 165 z-score: 225.5 E(): 3.5e-05%3B 26.0%25 identity in 127 aa overlap gene gene6278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6216 SCO6217 SCO6217 SC9G1.07c SC9G1.07c 6830637 6831287 - hypothetical protein SC9G1.07c%2C unknown%2C len: 216 aa%3B similar to TR:CAB42748 (EMBL:AL049841) Streptomyces coelicolor hypothetical 40.6 KD protein SCE9.02c%2C 391 aa%3B fasta scores: opt: 158 z-score: 169.6 E(): 0.045%3B 28.8%25 identity in 198 aa overlap gene gene6279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6217 SCO6218 SCO6218 SC9G1.08c SC9G1.08c 6831346 6831945 - phosphatase SC9G1.08c%2C possible phosphatase%2C len: 199 aa%3B similar to SW:COBC_SALTY (EMBL:U12808) Salmonella typhimurium alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) CobC%2C 234 aa%3B fasta scores: opt: 239 z-score: 291.8 E(): 7e-09%3B 31.8%25 identity in 201 aa overlap. Contains match to Pfam entry PF00300 PGAM%2C Phosphoglycerate mutase family gene gene6280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6218 SCO6219 SCO6219 SC2H4.01 SC2H4.01 6832135 6835920 + Ser/Thr protein kinase SC2H4.01%2C probable ATP/GTP binding protein%2C partial CDS%2C len: >606 aa%3B contains PS00017 ATP /GTP-binding site motif A (P-loop)~SC9G1.09%2C possible Ser/Thr protein kinase (partial CDS)%2C len: >688 aa%3B low similarity to TR:O54228 (EMBL:AJ223176) Streptomyces granaticolor ser/thr protein kinase (EC 2.7.1.37) (phosphorylase B kinase kinase) (glycogen synthase A kinase) (hydroxyalkyl-protein kinase) (serine(threonine) protein kinase)%2C Pkg4%2C 761 aa%3B fasta scores: opt: 142 z-score: 146.7 E(): 0.84%3B 25.6%25 identity in 406 aa overlap. Contains possible hydrophobic membrane spanning region gene gene6281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6219 SCO6220 SCO6220 SC2H4.02 SC2H4.02 6836057 6842608 + hypothetical protein SC2H4.02%2C unknown%2C len: 2183%3B very limited similarity to proteins of the RHS family e.g. WAPA_BACSU wall-associated protein precursor (2334 aa)%2C fasta scores%3B opt: 141 z-score: 296.8 E(): 2.7e-09%2C 23.4%25 identity in 1237 aa overlap%2C and RHSA_ECOLI RHSA protein precursor (1377 aa)%2C fasta scores%3B opt: 135 z-score: 222.4 E(): 3.8e-05%2C 23.0%25 identity in 1016 aa overlap. Contains possible membrane anchor around aa 1900. Alternative start at aa 27 would give N-terminal signal sequence gene gene6282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6220 SCO6221 SCO6221 SC2H4.03 SC2H4.03 6842700 6843161 + lipoprotein SC2H4.03%2C possible lipoprotein%2C len: 153 aa%3B contains possible N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6221 SCO6222 SCO6222 SC2H4.04c SC2H4.04c 6843172 6844380 - aminotransferase AlaT broad specificity%3B family IV%3B in Corynebacterium glutamicum this protein can use glutamate%2C 2-aminobutyrate%2C and aspartate as amino donors and pyruvate as the acceptor gene gene6284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6222 SCO6223 SCO6223 SC2H4.05 SC2H4.05 6844468 6845118 + hypothetical protein SC2H4.05%2C unknown%2C len: 216 aa%3B similar to hypothetical proteins from many organisms e.g. TR:P71983 (EMBL:Z81360) Mycobacterium tuberculosis MTCY04C12.10C (236 aa)%2C fasta scores%3B opt: 276 z-score: 307.9 E(): 6.6e-10%2C 46.0%25 identity in 100 aa overlap gene gene6285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6223 SCO6224 SCO6224 SC2H4.06c SC2H4.06c 6845172 6845987 - hypothetical protein SC2H4.06c%2C probable hypothetical protein%2C len: 271 aa%3B contains N-terminal signal sequence gene gene6286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6224 SCO6225 SCO6225 SC2H4.07c SC2H4.07c 6845987 6847252 - hypothetical protein SC2H4.07c%2C probable hypothetical protein%2C len: 421 aa%3B similar in C-terminus to B. subtilis TR:P70960 (EMBL:Z81356%3B) hypothetical protein ywmC precursor (227 aa)%2C fasta scores%3B opt: 319 z-score: 219.2 E(): 5.8e-05%2C 29.6%25 identity in 216 aa overlap gene gene6287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6225 SCO6226 SCO6226 SC2H4.08c SC2H4.08c 6847315 6848841 - hypothetical protein SC2H4.08c%2C unknown%2C len: 508 aa%3B some similarity to Rhizobium sp. NGR234 plasmid pNGR234a hypothetical protein Y4XN_RHISN (628 aa)%2C fasta scores%3B opt: 116 z-score: 207.6 E(): 0.00026%2C 26.4%25 identity in 641 aa overlap. Also some similarity to divergent CDS SC2H4.09 (E(): 0.00044%2C 29.1%25 identity in 553 aa overlap) gene gene6288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6226 SCO6227 SCO6227 SC2H4.09 SC2H4.09 6848969 6850522 + hypothetical protein SC2H4.09%2C unknown%2C len: 517 aa%3B some similarity to Rhizobium sp. NGR234 plasmid pNGR234a hypothetical protein Y4XN_RHISN (628 aa)%2C fasta scores%3B opt: 148 z-score: 254.8 E(): 6e-07%2C 25.9%25 identity in 495 aa overlap. Also weak similarity to S. coelicolor SC4H2.21 (E(): 1.8e-06%2C 33.2%25 identity in 581 aa overlap) and to divergent CDS SC2H4.08c (E(): 0.0012%2C 29.1%25 identity in 553 aa overlap) gene gene6289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6227 SCO6228 SCO6228 SC2H4.10 SC2H4.10 6850590 6851204 + hypothetical protein SC2H4.10%2C unknown%2C len: 204 aa gene gene6290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6228 SCO6229 SCO6229 SC2H4.11c SC2H4.11c 6851212 6852093 - sugar transport system permease SC2H4.11c%2C probable sugar transport system permease%2C len: 293 aa%3B similar to many e.g. MALD_STRPN maltodextrin transport system permease (277 aa)%2C fasta scores%3B opt: 394 z-score: 585.4 E(): 2.3e-25%2C 29.1%25 identity in 268 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 58.30%2C E-value 1.6e-13 gene gene6291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6229 SCO6230 SCO6230 SC2H4.12c SC2H4.12c 6852090 6853064 - sugar transport system permease SC2H4.12c%2C probable sugar transport system permease%2C len: 324 aa%3B similar to many e.g. AMYD_THETU potential starch degradation products transport system permease (292 aa)%2C fasta scores%3B opt: 479 z-score: 571.8 E(): 1.3e-24%2C 28.8%25 identity in 281 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 58.80%2C E-value 1.2e-13 gene gene6292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6230 SCO6231 SCO6231 SC2H4.13c SC2H4.13c 6853107 6854429 - sugar transport system sugar-binding lipoprotein SC2H4.13c%2C probable sugar transport system sugar-binding lipoprotein%2C len: 440 aa%3B some similarity to several%2C e.g. TR:Q46443 (EMBL:M57692) Thermoanaerobacterium thermosulfurigenes maltose-binding protein precursor (446 aa)%2C fasta scores%3B opt: 239 z-score: 192.4 E(): 0.0018%2C 23.5%25 identity in 366 aa overlap. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site sugar transport system sugar-binding lipoprotein gene gene6293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6231 SCO6232 SCO6232 SC2H4.14 SC2H4.14 6854701 6857163 + beta-mannosidase SC2H4.14%2C probable beta-mannosidase%2C len: 820 aa%3B similar to several eukaryotic beta-mannosidases%2C e.g. MANB_HUMAN beta-mannosidase precursor (EC 3.2.1.25) (879 aa)%2C fasta scores%3B opt: 679 z-score: 909.3 E(): 0%2C 31.4%25 identity in 684 aa overlap gene gene6294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6232 SCO6233 SCO6233 SC2H4.15 SC2H4.15 6857160 6858188 + transcriptional regulator SC2H4.15%2C probable transcriptional regulator%2C len: 342 aa%3B similar to many members of the lacI family e.g. CCPA_BACME glucose-resistance amylase regulator (Bacillus megaterium) (332 aa)%2C fasta scores%3B opt: 448 z-score: 548.6 E(): 2.6e-23%2C 29.8%25 identity in 336 aa overlap. Contains helix-turn-helix motif from aa 9-30 (Score 1778%2C +5.24 SD) and Pfam matches to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C score 30.40%2C E-value 4.7e-07 and to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C score 44.00%2C E-value 3.4e-09 gene gene6295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6233 SCO6234 SCO6234 manA manA 6858440 6859594 + beta-mannosidase SC2H4.16%2C manA%2C probable beta-mannosidase%2C len: 384 aa%3B 94.5%25 identical to MANA_STRLI mannan endo-1%2C4-beta-mannosidase precursor (363 aa). Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00150 cellulase%2C Cellulase (glycosyl hydrolase family 5)%2C score 104.70%2C E-value 1.8e-27 gene gene6296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6234 SCO6235 SCO6235 SC2H4.17c SC2H4.17c 6859658 6859903 - hypothetical protein SC2H4.17c%2C unknown%2C len: 81 aa%3B similar to S. coelicolor TR:Q53896 (EMBL:X60316) abaA orfD (75 aa)%2C fasta scores%3B opt: 121 z-score: 174.5 E(): 0.018%2C 37.7%25 identity in 53 aa overlap. Also similar to SC4G2.04 (E(): 4.6e-12%2C 54.5%25 identity in 55 aa overlap) gene gene6297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6235 SCO6236 SCO6236 SC2H4.18c SC2H4.18c 6859900 6860775 - DNA-binding protein SCAH10.01c%2C possible DNA-binding protein%2C len: >270 aa%3B similar to TR:Q9Z543 (EMBL:AL035212) Streptomyces coelicolor binding protein%2C SC9B2.16c%2C len: 303 aa%3B fasta scores: opt: 466 z-score: 574.2 E(): 1.3e-24%3B 34.1%25 identity in 252 aa overlap. Contains a possible helix-turn-helix motif between residues 612..677 (+3.39 SD)~SC2H4.18c%2C unknown%2C partial CDS%2C len: >55 aa%3B some similarity to the C-terminus of S. coelicolor hypothetical protein SC4G2.03%2C fasta scores%3B (E(): 0.018%2C 32.7%25 identity in 52 aa overlap) gene gene6298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6236 SCO6237 SCO6237 SCAH10.02 SCAH10.02 6860882 6861364 + regulatory protein SCAH10.02%2C possible regulatory protein%2C len: 160 aa%3B similar to TR:Q53897 (EMBL:X60316) Streptomyces coelicolor A3(2) ORFA in AbaA gene%2C len: 192 aa%3B fasta scores: opt: 245 z-score: 318.1 E(): 2.4e-10%3B 36.5%25 identity in 148 aa overlap and to TR:O86675 (EMBL:SC4G2) Streptomyces coelicolor SC4G2.02c%2C 196 aa%3B fasta scores: opt: 436 z-score: 440.2 E(): 3.4e-19%3B 51.4%25 identity in 138 aa overlap gene gene6299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6237 SCO6238 SCO6238 SCAH10.03 SCAH10.03 6861417 6862082 + hypothetical protein SCAH10.03%2C hypothetical protein%2C len: 221 aa%3B similar to various hypothetical proteins%2C e.g. TR:O53480 (EMBL:AL021899) Mycobacterium tuberculosis hypothetical 23.2 kD protein%2C 213 aa%3B fasta scores: opt: 381 z-score: 468.2 E(): 1e-18%3B 38.3%25 identity in 201 aa overlap gene gene6300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6238 SCO6239 SCO6239 SCAH10.04c SCAH10.04c 6862307 6863275 - sigma factor SCAH10.04c%2C possible sigma factor%2C len: 322 aa%3B similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor sigma factor%2C SCH10.04c%2C 294 aa%3B fasta scores: opt: 379 z-score: 438.7 E(): 4.6e-17%3B 34.7%25 identity in 291 aa overlap and to (EMBL:AL132707) Streptomyces coelicolor SCF51.13c%2C 298 aa%3B fasta scores: opt: 833 z-score: 802.7 E(): 0%3B 44.9%25 identity in 305 aa overlap gene gene6301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6239 SCO6240 SCO6240 SCAH10.05c SCAH10.05c 6863358 6864092 - hypothetical protein SCAH10.05c%2C hypothetical protein%2C len: 244 aa%3B similar to various hypothetical proteins%2C e.g. TR:CAB52958 (EMBL:AL109950) Streptomyces coelicolor hypothetical 25.2 KD protein SCJ4.24c%2C len: 242 aa%3B fasta scores: opt: 504 z-score: 580.0 E(): 6.2e-25%3B 36.9%25 identity in 241 aa overlap gene gene6302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6240 SCO6241 SCO6241 SCAH10.06 SCAH10.06 6864326 6864658 + hypothetical protein SCAH10.06%2C unknown%2C len: 110 aa gene gene6303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6241 SCO6242 SCO6242 SCAH10.07 SCAH10.07 6864755 6865669 + hypothetical protein SCAH10.07%2C hypothetical protein%2C len: 304 aa%3B similar to TR:Q9RCK7 (EMBL:AJ242827) Streptomyces tendae hypothetical protein (fragment) 266 aa%3B fasta scores: opt: 739 Z-score: 852.1 E(): 7.9e-40%3B 54.435%25 identity in 248 aa overlap gene gene6304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6242 SCO6243 SCO6243 aceB1 aceB1 6865736 6867358 - malate synthase Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle gene gene6305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6243 SCO6244 SCO6244 SCAH10.09c SCAH10.09c 6867543 6868166 - hypothetical protein SCAH10.09c%2C hypothetical protein%2C len: 207 aa%3B highly similar to TR:P72363 (EMBL:U63518) Streptomyces arenae ORFuMS%2C len: 201 aa%3B fasta scores: opt: 498 z-score: 585.3 E(): 3.2e-25%3B 48.8%25 identity in 209 aa overlap gene gene6306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6244 SCO6245 SCO6245 SCAH10.10 SCAH10.10 6868320 6868634 + hypothetical protein SCAH10.10%2C unknown%2C len: 104 aa gene gene6307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6245 SCO6246 SCO6246 iclR iclR 6868657 6869469 - transcriptional regulator for glyoxylate bypass SCAH10.11c%2C iclR%2C transcriptional regulator for glyoxylate bypass%2C len: 270 aa%3B highly similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR%2C 274 aa%3B fasta scores: opt: 538 Z-score: 603.9 E(): 5.5e-26%3B 40.234%25 identity in 256 aa overlap and to SW:GYLR_STRCO (EMBL:X14188) Streptomyces coelicolor glycerol operon regulatory protein%2C 254 aa%3B fasta scores: opt: 333 z-score: 389.8 E(): 2.4e-14%3B 32.8%25 identity in 250 aa overlap. Contains match to Pfam entry PF01614 IclR%2C Bacterial transcriptional regulator and a possible helix-turn-helix motif at residues 39..60 (+2.51 SD) gene gene6308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6246 SCO6247 SCO6247 SCAH10.12 SCAH10.12 6869725 6871062 + allantoinase SCAH10.12%2C possible allantoinase%2C len: 445 aa%3B similar SW:ALLA_YEAST (EMBL:M69294) Saccharomyces cerevisiae%2C allantoinase 460 aa%3B fasta scores: opt: 1232 z-score: 1441.5 E():0 %3B 48.3%25 identity in 408 aa overlap and to SW:ALLA_BACSU (EMBL:Z99120) Bacillus subtilis allantoinase (EC 3.5.2.5) YunH%2C 446 aa%3B fasta scores: opt: 973 z-score: 1139.0 E(): 0%3B 36.5%25 identity in 444 aa overlap. Contains match to Pfam entry PF00744 Dihydrooratase%2C Dihydroorotase-like gene gene6309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6247 SCO6248 SCO6248 SCAH10.13 SCAH10.13 6871127 6872257 + allantoicase catalyzes the formation of S-ureidoglycolate and urea from allantoate gene gene6310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6248 SCO6249 SCO6249 SCAH10.14c SCAH10.14c 6872329 6873105 - 3-oxoacyl-ACP reductase SCAH10.14c%2C probable 3-oxoacyl-[acyl-carrier-protein] reductase%2C len: 258 aa%3B similar to TR:CAB42951 (EMBL:AL049863) Streptomyces coelicolor dehydrogenase/reductase%2C SC5H1.26%2C 245 aa%3B fasta scores: opt: 560 z-score: 573.5 E(): 1.4e-24%3B 45.1%25 identity in 246 aa overlap and to SW:FABG_BACSU (EMBL:U59433) Bacillus subtilis%2C 3-oxoacyl-[acyl-carrier-protein] reductase%2C FabG 246 aa%3B fasta scores: opt: 471 z-score: 484.6 E(): 1.3e-19%3B 36.0%25 identity in 247 aa overlap gene gene6311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6249 SCO6250 SCO6250 SCAH10.15 SCAH10.15 6873167 6873760 + transporter SCAH10.15%2C probable transport protein%2C len: 197 aa%3B similar to C-terminus of TR:CAB55652 (EMBL:AL117385) Streptomyces coelicolor transmembrane efflux protein SC5G9.04c 489 aa%3B fasta scores: opt: 230 z-score: 254.1 E(): 8.8e-07%3B 33.5%25 identity in 185 aa overlap and to C-terminus of SW:PUR8_STRLP (EMBL:X76855) Streptomyces lipmanii (Streptomyces alboniger) puromycin resistance protein%2C Pur8%2C 503 aa%3B fasta scores: opt: 237 z-score: 261.4 E(): 3.5e-07%3B 30.2%25 identity in 162 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6250 SCO6251 SCO6251 SCAH10.16 SCAH10.16 6873849 6874406 + reductase SCAH10.16%2C possible reductase%2C len: 185 aa%3B similar to TR:Q9ZGD0 (EMBL:AF080235) Streptomyces cyanogenus reductase homologue LanO%2C len: 193 aa%3B fasta scores: opt: 398 z-score: 505.3 E(): 9e-21%3B 41.0%25 identity in 188 aa overlap gene gene6313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6251 SCO6252 SCO6252 SCAH10.17c SCAH10.17c 6874704 6874904 - hypothetical protein SCAH10.17c%2C membrane protein%2C len: 66 aa. Contains possible hydrophobic membrane spanning regions gene gene6314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6252 SCO6253 SCO6253 SCAH10.18 SCAH10.18 6875083 6876336 + two-component sensor kinase SCAH10.18%2C possible two-component sensor kinase%2C len: 417 aa%3B similar to TR:O86631 EMBL%3B AL031155 Streptomyces coelicolor two-component sensor SC3A7.30%2C 429 aa%3B fasta scores: opt: 588 z-score: 615.4 E(): 6.6e-27%3B 35.0%25 identity in 412 aa overlap and C-terminus to C-terminus of TR:Q53893 (EMBL:U51332) Streptomyces coelicolor AbsA1%2C 571 aa%3B fasta scores: opt: 477 z-score: 492.4 E(): 4.7e-20%3B 40.1%25 identity in 262 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6253 SCO6254 SCO6254 SCAH10.19 SCAH10.19 6876381 6877070 + two-component system response regulator SCAH10.19%2C possible two-component system response regulator%2C 229 aa%3B similar to TR:Q53894 (EMBL:U51332) Streptomyces coelicolor AbsA2%2C 222 aa%3B fasta scores: opt: 573 z-score: 662.7 E(): 1.5e-29%3B 45.7%25 identity in 221 aa overlap%2C to SW:NARL_ECOLI (EMBL:X13360) Escherichia coli nitrate/nitrite response regulator protein 216 aa%3B fasta scores: opt: 457 z-score: 531.1 E(): 3.3e-22%3B 36.1%25 identity in 208 aa overlap and to TR:CAB40929 (EMBL:SCE126) Streptomyces coelicolor SCE126.07c%2C 224 aa%3B fasta scores: opt: 664 z-score: 584.6 E(): 3.1e-27%3B 48.4%25 identity in 219 aa overlap. Contains two matches to Pfam entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family gene gene6316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6254 SCO6255 SCO6255 SCAH10.20c SCAH10.20c 6877162 6878175 - dehydrogenase SCAH10.20%2C possible dehydrogenase%2C len: 337 aa%3B similar to SW:STRI_STRGR (EMBL:Y00459) Stretomyces griseus streptomycin resistance protein StrI%2C 348 aa%3B fasta scores: opt: 582 z-score: 670.0 E(): 6.1e-30%3B 39.5%25 identity in 344 aa overlap and to SW:MI2D_BACSU (EMBL%3BM76431) Bacillus subtilis myo-inositol dehydrogenase (EC 1.1.1.18) Idh or IolG OR e83G%2C 330 aa%3B fasta scores: opt: 534 z-score: 615.6 E(): 6.5e-27%3B 28.8%25 identity in 351 aa overlap. Contains match to Pfam entry PF01408 GFO_IDH_MocA%2C oxidoreductase family gene gene6317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6255 SCO6256 SCO6256 SCAH10.21 SCAH10.21 6878304 6879041 + transcriptional regulator SCAH10.21%2C possible transcriptional regulator%2C len: 245 aa%3B similar to SW:YURK_BACSU (EMBL:Z99120) Bacillus subtilis hypothetical transcriptional regulator in hom-MrgA intergenic region YurK%2C 242 aa%3B fasta scores: opt: 333 z-score: 402.6 E(): 4.7e-15%3B 26.8%25 identity in 235 aa overlap and to SW:FARR_ECOLI (EMBL:X15790) Escherichia coli%2C response regulator FarR%2C 240 aa%3B fasta scores: opt: 270 z-score: 328.3 E(): 6.5e-11%3B 26.1%25 identity in 226 aa overlap. Contains match to Pfam entry PF00392 gntR%2C bacterial regulatory proteins%2C gntR family and a possible helix-turn-helix motif at residues 18458..18523 gene gene6318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6256 SCO6257 SCO6257 SCAH10.22 SCAH10.22 6879297 6880301 + ABC transporter sugar binding lipoprotein SCAH10.22%2C probable ABC transport system sugar binding lipoprotein%2C len: 334 aa%3B similar to TR:CAB41563 (EMBL:AL049727) Streptomyces coelicolor solute binding protein%2C 337 aa%3B fasta scores: opt: 1003 z-score: 1130.9 E():0%3B 49.8%25 identity in 325 aa overlap%2C to SW:RBSB_BACSU (EMBL:Z92953) Bacillus subtilis D-ribose-binding protein precursor RbsB%2C 305 aa%3B fasta scores: opt: 206 z-score: 238.7 E(): 6.3e-06%3B 23.0%25 identity in 235 aa overlap and to TR:CAB41563 (EMBL:SC9B1) Streptomyces coelicolor SC9B1.17c%2C 337 aa%3B fasta scores: opt: 1003 z-score: 1045.2 E(): 0%3B 49.8%25 identity in 325 aa overlap. Contains match to Pfam entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and a match situated in the correct position to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains also possible N-terminal region signal peptide sequence gene gene6319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6257 SCO6258 SCO6258 SCAH10.23 SCAH10.23 6880298 6881338 + sugar ABC transporter permease SCAH10.23%2C probable ABC transport system sugar permease%2C len: 346 aa%3B similar to TR:O68120 (EMBL:AF010496) Rhodobacter capsulatus ribose transport system permease RbsC%3B fasta scores: opt: 445 z-score: 508.0 E(): 6.4e-21%3B 30.5%25 identity in 351 aa overlap and to SW:RBSC_ECOLI (EMBL:L10328) Escherichia coli ribose transport system permease RbsC%2C len: 321 aa%3B fasta scores: opt: 286 z-score: 329.9 E(): 5.3e-11%3B 30.1%25 identity in 329 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6258 SCO6259 SCO6259 SCAH10.24 SCAH10.24 6881335 6882126 + sugar ABC transporter ATP-binding protein SCAH10.24%2C probable ABC sugar transport ATP binding protein%2C len: 263 aa%3B similar to TR:O68121 (EMBL:AF010496) Rhodobacter capsulatus ribose transport ATP-binding protein%2C 305 aa%3B fasta scores: opt: 612 z-score: 706.1 E(): 5.9e-32%3B 45.6%25 identity in 217 aa overlap%2C to SW:RBSA_ECOLI (EMBL:M13169) Escherichia coli%2C ribose transport ATP-binding protein RbsA%2C 501 aa%3B fasta scores: opt: 509 z-score: 585.6 E(): 3e-25%3B 31.5%25 identity in 254 aa overlap and to TR:CAA15787 (EMBL:SC7B7) Streptomyces coelicolor St7B7.07%2C 260 aa%3B fasta scores: opt: 592 z-score: 521.2 E(): 1e-23%3B 43.1%25 identity in 246 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and Prosite PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene6321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6259 SCO6260 SCO6260 SCAH10.25 SCAH10.25 6882242 6883390 + sugar kinase SCAH10.25%2C possible sugar kinase%2C len: 382 aa%3B similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) (glucose kinase) Glk%2C 317 aa%3B fasta scores: opt: 1022 z-score: 1142.9 E(): 0%3B 46.6%25 identity in 311 aa overlap and to TR:CAB51974 EMBL:SC6E10 Streptomyces coelicolor SC6E10.20c%2C 317 aa%3B fasta scores: opt: 1022 z-score: 1035.4 E(): 0%3B 46.6%25 identity in 311 aa overlap. Contains a match to Pfam entry PF00480 ROK%2C ROK family and Prosite entry PS01125 ROK family signature gene gene6322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6260 SCO6261 SCO6261 SCAH10.26 SCAH10.26 6883459 6883968 + hypothetical protein SCAH10.26%2C probable hypothetical protein%2C len: 169 aa%3B similar to TR:Q9F1W0 (EMBL:AB040071) Streptomyces griseus hypothetical protein%2C 198 aa%3B fasta scores: opt: 647 Z-score: 783.2 E(): 5.5e-36%3B 55.030%25 identity in 169 aa overlap. Contains possible N-terminal region signal sequence gene gene6323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6261 SCO6262 SCO6262 SCAH10.27 SCAH10.27 6884138 6887071 + helicase SCAH10.27%2C possible helicase%2C len: 977 aa%3B similar to TR:O53499 (EMBL:AL021924) Mycobacterium tuberculosis helicase%2C 1013 aa%3B fasta scores: opt: 1308 z-score: 1370.7 E(): 0%3B 39.7%25 identity in 939 aa overlap. Contains two matches to Pfam entries PF00176 SNF2_N%2C SNF2 and others N-terminal domain and PF00271 helicase_C%2C Helicases conserved C-terminal domain gene gene6324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6262 SCO6263 SCO6263 SCAH10.28 SCAH10.28 6887068 6889461 + hypothetical protein SCAH10.28%2C conserved hypothetical protein%2C len: 797 aa%3B C-terminus identical to previously sequenced TR: O86854 (EMBL:AJ007731) Streptomyces coelicolor hypothetical 59.8 KD protein orfZ%2C 566 aa%3B fasta scores: opt: 3713 z-score: 2921.3 E(): 0%3B 96.6%25 identity in 559 aa overlap. Regions similar to others eg. TR:AAK46444 (EMBL:AE007065). gene gene6325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6263 SCO6264 SCO6264 SCAH10.29 SCAH10.29 6889624 6890412 + reductase SCAH10.29%2C reductase orfX%2C len: 262 aa%3B identical to previously sequenced TR:O86853 (EMBL:AJ007731) Streptomyces coelicolor 3-ketoacyl-ACP/CoA reductase%2C 244 aa and to SW:VER1_ASPPA (EMBL:M91369) Aspergillus parasiticus versicolor reductase (EC 1.1.-.-)(ver-1) 262 aa%3B fasta scores opt: 571 z-score: 634.6 E(): 5.7e-28%3B 40.9%25 identity in 259 aa overlap. Contains match to Pfam entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene6326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6264 SCO6265 SCO6265 SCAH10.30c SCAH10.30c 6890528 6891175 - gamma-butyrolactone binding protein SCAH10.30c%2C scbR%2C gamma-butyrolactone binding protein%2C len: 215 aa%3B identical to previously sequenced TR:O86852 (EMBL:AJ007731) Streptomyces coelicolor gamma-butyrolactone binding protein%2C 215 aa and to TR:O24741 (EMBL:AB001683) Streptomyces sp. FarA%2C 221 aa%3B fasta scores: opt: 771 z-score: 937.4 E(): 0%3B 57.2%25 identity in 208 aa overlap. Contains match to Pfam entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and to Prosite entry PS01081 Bacterial regulatory proteins%2C tetR family signature. Contains also a possible helix-turn-helix motif at residues 30..51 (+3.66 SD) gene gene6327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6265 SCO6266 SCO6266 SCAH10.31 SCAH10.31 6891293 6892237 + ScbA protein SCAH10.31%2C scbA%2C len: 314 aa%3B identical to previously sequenced TR:O86851 (EMBL:AJ007731) Streptomyces coelicolor ScbA protein%2C 314 aa and to SW:AFSA_STRGR (EMBL:M24250) Streptomyces griseus possible A-factor biosynthesis enzyme AfsA%2C 301 aa%3B fasta scores: opt: 1345 z-score: 1570.4 E(): 0%3B 66.1%25 identity in 292 aa overlap gene gene6328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6266 SCO6267 SCO6267 SCAH10.32 SCAH10.32 6892353 6893207 + hypothetical protein SCAH10.32%2C hypothetical protein orfA%2C len: 284 aa%3B identical to previously sequenced TR:O86850 (EMBL:AJ007731) Streptomyces coelicolor hypothetical 31.0 kD protein%2C 284 aa and to various hypothetical proteins%2C e.g. TR:O68920 (EMBL:AF058302) Streptomyces roseofulvus FrnS%2C 305 aa%3B fasta scores: opt: 591 z-score: 680.7 E(): 1.5e-30%3B 41.5%25 identity in 282 aa overlap gene gene6329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6267 SCO6268 SCO6268 SCAH10.33c SCAH10.33c 6893258 6894022 - histidine kinase SCAH10.33c%2C possible histidine kinase orfB%2C len: 254 aa%3B identical to previously sequenced TR:O86849 (EMBL:AJ007731) Streptomyces coelicolor histidine kinase ORFB%2C 310 aa and to SW:UHPB_SALTY (EMBL:M89480) Salmonella typhimurium sensor protein UhpB%2C 500 aa%3B fasta scores: opt: 219 z-score: 254.8 E(): 8e-07%3B 33.3%25 identity in 204 aa overlap. Contains a match to Prosite entry PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site gene gene6330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6268 SCO6269 SCO6269 SCAH10.34c SCAH10.34c 6894148 6895200 - 2-oxoglutarate ferredoxin oxidoreductase subunit beta catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin gene gene6331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6269 SCO6270 SCO6270 SCAH10.35c SCAH10.35c 6895193 6897085 - oxidoreductase alpha-subunit SCAH10.35c%2C possible oxidoreductase alpha-subunit%2C len: 630 aa%3B similar to TR:O53182 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit%2C 653 aa%3B fasta scores: opt: 2008 z-score: 2153.9 E(): 0%3B 66.4%25 identity in 614 aa overlap gene gene6332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6270 SCO6271 SCO6271 accA1 accA1 6897089 6898861 - acyl-CoA carboxylase complex A subunit SCAH10.36c%2C accA1%2C probable acyl-CoA carboxylase complex (partial)%2C len: >137 aa%3B identical to previously sequenced TR:AAD28553 (EMBL:AF113603) Streptomyces coelicolor acyl-CoA carboxylase complex A subunit%2C AccA1%2C 590 aa%2C to TR:AAD37851 (EMBL:AF126429) Streptomyces venezuelae JadJ%2C 584 aa%3B fasta scores: opt: 674 z-score: 748.1 E(): 0%3B 79.7%25 identity in 138 aa overlap and to TR:Q54119 (EMBL:X92557) Saccharopolyspora erythraea (Streptomyces erythraeus) biotin carboxylase and biotin carboxyl carrier protein BcpA2%2C 591 aa%3B fasta scores: opt: 455 z-score: 508.1 E(): 6.3e-21%3B 55.6%25 identity in 133 aa overlap~SC2C4.01c%2C accA1%2C acyl-CoA carboxylase complex A subunit (fragment)%2C len: >491 aa%3B identical to N-terminal region of previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor acyl-CoA carboxylase complex A subunit AccA1%2C 590 aa and also identical to N-terminal region of TR:Q9X4K6 (EMBL:AF113604) Streptomyces coelicolor acyl-CoA carboxylase complex A subunit AccA2%2C 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain%2C Carbamoyl-phosphate synthase (CPSase) and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 gene gene6333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6271 SCO6272 SCO6272 SC2C4.02 SC2C4.02 6899170 6900822 + FAD-binding protein SC2C4.02%2C possible FAD-binding protein%2C len: 550 aa%3B similar to TR:Q9ZAR8 (EMBL:U80222) Streptomyces peucetius ceasius DnrW%2C 485 aa%3B fasta scores: opt: 1323 z-score: 1315.4 E(): 0%3B 45.3%25 identity in 470 aa overlap. Contains Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain. Also contains possible N-terminal region signal peptide sequence gene gene6334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6272 SCO6273 SCO6273 SC2C4.03c SC2C4.03c 6900898 6907356 - type I polyketide synthase SC2C4.03c%2C probable type I polyketide synthase%2C len: 2152 aa%3B N-terminal domain almost identical to TR:Q9L8J0 (EMBL:AF202898) Streptomyces coelicolor A3(2) type I polyketide synthase (fragment)%2C 720 aa%3B fasta scores: opt: 4356 z-score: 4494.6 E(): 0%3B 93.8%25 identity in 721 aa overlap and C-terminal domain similar to SW:HETM_ANASP (EMBL:L22883) Anabaena sp. polyketide synthase HetM%2C 506 aa%3B blastp scores: Score%3D 761 (267.9 bits)%2C Expect%3D 2.2e-74%2C Sum P(2)%3D 2.2e-74%3B Identities%3D 184/491 (37%25)%2C Positives%3D 278/491 (56%25). Also highly similar%2C in this same cosmid%2C to the N-terminal region of SC2C4.04c and to SC2C4.05c. Contains Pfam matches to entries PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C PF00698 Acyl_transf%2C Acyl transferase domain and PF00550 pp-binding%2C Phosphopantetheine attachment site and matches to Prosite entries PS00606 Beta-ketoacyl synthases active site%2C PS00340 Growth factor and cytokines receptors family signature 2 and PS00012 Phosphopantetheine attachment site gene gene6335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6273 SCO6274 SCO6274 SC2C4.04c SC2C4.04c 6907413 6918143 - type I polyketide synthase SC2C4.04c%2C probable type I polyketide synthase%2C len: 3576 aa%3B similar to TR:Q9ZGI4 (EMBL:AF079138) Streptomyces venezuelae type I polyketide synthase PikAII%2C 3739 aa%3B fasta scores: opt: 3355 z-score: 3346.1 E(): 0%3B 39.7%25 identity in 4066 aa overlap. Also highly similar%2C in this same cosmid%2C to SC2C4.03c and to SC2C4.05c.. Contains Pfam matches to entries 2x PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C 2x PF00698 Acyl_transf%2C Acyl transferase domain%2C 2x PF00550 pp-binding%2C Phosphopantetheine attachment site and matches to Prosite entries 2x PS00606 Beta-ketoacyl synthases active site%2C 2x PS00216 Sugar transport proteins signature 1%2C 2x PS00012 Phosphopantetheine attachment site and PS00173 Xylose isomerase signature 2. Also contains a possible coiled-coil region at the N-terminal domain at approx aa 1..25. Protein containing duplicate subunits such that the N-terminal region is equivalent to the C-terminal region gene gene6336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6274 SCO6275 SCO6275 SC1G7.01c SC1G7.01c 6918286 6931959 - type I polyketide synthase SC1G7.01c%2C probable type I polyketide synthase (fragment)%2C len: >3488 aa%3B similar to the N-terminal region of TR:Q9L4W3 (EMBL:AF263912) Streptomyces noursei nystatin polyketide synthase NysC%2C 11096 aa%3B fasta scores: opt: 7454 Z-score: 6765.5 bits: 1268.6 E(): 0%3B 45.788%25 identity in 4285 aa overlap%2C to TR:O33956 (EMBL:U78289) Streptomyces fradiae tylactone synthase modules 4 %26 5 TylG%2C 3729 aa%3B fasta scores: opt: 3409 Z-score: 3092.3 bits: 587.4 E(): 1.2e-164%3B 44.860%25 identity in 2568 aa overlap and to TR:CAC22145 (EMBL:AL512902) Streptomyces coelicolor SC2C4.04c%2C 3577 aa%3B fasta scores: opt: 4872 Z-score: 3412.6 bits: 646.6 E(): 2.3e-184%3B 58.281%25 identity in 2560 aa overlap. Contains Pfam matches to entries 3x PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C 3x PF02801 ketoacyl-synt_C%2C Beta-ketoacyl synthase%2C 3x PF00698 Acyl_transf%2C Acyl transferase domain%2C PF00550 pp-binding%2C Phosphopantetheine attachment site%2C PF00550 pp-binding%2C Phosphopantetheine attachment site and matches to Prosite entries PS00012 Phosphopantetheine attachment site and PS00606 Beta-ketoacyl synthases active site~SC2C4.05c%2C probable type I polyketide synthase (fragment)%2C len: >1107 aa%3B similar to C-terminal region of TR:O33955 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 TylG%2C 1864 aa%3B fasta scores: opt: 2105 z-score: 2202.2 E(): 0%3B 46.0%25 identity in 1161 aa overlap. Also highly similar%2C in this same cosmid%2C to SC2C4.03c and SC2C4.04c. Contains Pfam matches to entries PF00698 Acyl_transf%2C Acyl transferase domain and PF00550 pp-binding%2C Phosphopantetheine attachment site and matches to Prosite entries PS00216 Sugar transport proteins signature 1 and PS00012 Phosphopantetheine attachment site gene gene6337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6275 SCO6276 SCO6276 SC1G7.02 SC1G7.02 6932285 6933607 + hypothetical protein SC1G7.02%2C possible hypothetical protein%2C len: 440 aa%3B similar to TR:Q9L0A8 (EMBL:AL163003) Streptomyces coelicolor hypothetical protein SCC24.09%2C 468 aa%3B fasta scores: opt: 777 Z-score: 867.4 bits: 169.7 E(): 1e-40%3B 36.303%25 identity in 449 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase gene gene6338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6276 SCO6277 SCO6277 SC1G7.03 SC1G7.03 6933604 6934464 + epoxide hydrolase SC1G7.03%2C possible epoxide hydrolase%2C len: 286 aa%3B similar to TR:Q42566 (EMBL:D16628) Arabidopsis thaliana epoxide hydrolase (EC 3.3.2.3) Seh or F18A8.11%2C 321 aa%3B fasta scores: opt: 351 Z-score: 406.4 bits: 83.3 E(): 4.8e-15%3B 29.560%25 identity in 318 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene6339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6277 SCO6278 SCO6278 SC1G7.04 SC1G7.04 6934507 6936138 + integral membrane transport protein SC1G7.04%2C possible integral membrane transport protein%2C len: 543 aa%3B similar to TR:Q9RMF9 (EMBL:AF201913) Streptomyces globisporus transmembrane membrane efflux protein SgcB%2C 521 aa%3B fasta scores: opt: 1451 Z-score: 1413.5 bits: 271.2 E(): 3.8e-71%3B 46.243%25 identity in 519 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6278 SCO6279 SCO6279 SC1G7.05 SC1G7.05 6936149 6937705 + diaminobutyrate-pyruvate aminotransferase SC1G7.05%2C probable diaminobutyrate-pyruvate aminotransferase%2C len: 518 aa%3B similar to SW:RHSA_RHIME (EMBL:AF110737) Rhizobium meliloti diaminobutyrate-pyruvate aminotransferase (EC 2.6.1.76) RhsA%2C 470 aa%3B fasta scores: opt: 423 Z-score: 464.1 bits: 95.4 E(): 2.9e-18%3B 30.704%25 identity in 469 aa overlap. Contains 2x Pfam matches to entry PF00202 aminotran_3%2C Aminotransferase class-III pyridoxal-phosphate gene gene6341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6279 SCO6280 SCO6280 SC1G7.06 SC1G7.06 6938012 6939643 + regulatory protein SC1G7.06%2C possible regulatory protein%2C len: 543 aa%3B similar to TR:Q54494 (EMBL:AJ224512) Streptomyces nogalater nogalamycin biosynthesis activator SnoA%2C 665 aa%3B fasta scores: opt: 542 Z-score: 521.9 bits: 106.6 E(): 1.8e-21%3B 32.919%25 identity in 483 aa overlap gene gene6342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6280 SCO6281 SCO6281 SC1G7.07 SC1G7.07 6939907 6941544 + FAD-binding protein SC1G7.07%2C probable FAD-binding protein%2C len: 545 aa%3B similar to TR:AAG23271 (EMBL:AY007564) Saccharopolyspora spinosa oxidoreductase SpnJ%2C 539 aa%3B fasta scores: opt: 1599 Z-score: 1759.4 bits: 335.3 E(): 2.1e-90%3B 45.785%25 identity in 522 aa overlap and to TR:Q9EX55 (EMBL:AL512902) Streptomyces coelicolor FAD-binding protein SC2C4.02%2C 550 aa%3B fasta scores: opt: 2105 Z-score: 2315.4 bits: 438.2 E(): 2.2e-121%3B 56.884%25 identity in 552 aa overlap. Contains Pfam match to entry PF01565 FAD_binding_4%2C FAD binding domain gene gene6343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6281 SCO6282 SCO6282 SC1G7.08c SC1G7.08c 6941746 6942543 - 3-oxoacyl-ACP reductase SC1G7.08c%2C probable 3-oxoacyl-[acyl-carrier protein] reductase%2C len: 265 aa%3B similar to SW:FABG_BACSU (EMBL:U59433) Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) FabG%2C 246 aa%3B fasta scores: opt: 531 Z-score: 586.7 bits: 116.1 E(): 4.3e-25%3B 41.036%25 identity in 251 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene6344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6282 SCO6283 SCO6283 SC1G7.09 SC1G7.09 6942661 6943506 + hypothetical protein SC1G7.09%2C conserved hypothetical protein%2C len: 281 aa%3B similar to TR:Q9RDJ2 (EMBL:AL136519) Streptomyces coelicolor hypothetical 29.0 kDa protein SCC57A.04c%2C 279 aa%3B fasta scores: opt: 648 Z-score: 723.6 bits: 141.7 E(): 1e-32%3B 44.912%25 identity in 285 aa overlap and to TR:O68920 (EMBL:AF058302) Streptomyces roseofulvus hypothetical protein FrnS%2C 305 aa%3B fasta scores: opt: 330 Z-score: 372.5 bits: 76.9 E(): 3.7e-13%3B 34.708%25 identity in 291 aa overlap gene gene6345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6283 SCO6284 SCO6284 SC1G7.10 SC1G7.10 6943673 6945265 + decarboxylase SC1G7.10%2C probable decarboxylase%2C len: 530 aa%3B similar to TR:AAK06793 (EMBL:AF324838) Streptomyces antibioticus simocyclinone biosynthesis decarboxylase involved in polyketide formation SimA12%2C 528 aa%3B fasta scores: opt: 2751 Z-score: 3055.0 bits: 574.9 E(): 1.4e-162%3B 75.803%25 identity in 529 aa overlap and to TR:O86517 (EMBL:AL031124) Streptomyces coelicolor carboyl transferase SC1C2.16%2C 527 aa%3B fasta scores: opt: 2715 Z-score: 3015.0 bits: 567.6 E(): 2.4e-160%3B 75.094%25 identity in 530 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans%2C Carboxyl transferase domain gene gene6346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6284 SCO6285 SCO6285 SC1G7.11 SC1G7.11 6945280 6945543 + hypothetical protein SC1G7.11%2C unknown%2C len: 87 aa. High content in alanine%2C arginine and serine amino acid residues gene gene6347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6285 SCO6286 SCO6286 SC1G7.12c SC1G7.12c 6945705 6946379 - regulatory protein SC1G7.12c%2C possible regulatory protein%2C len: 24 aa%3B similar to TR:O24739 (EMBL:AB001609) Streptomyces virginiae butyrolactone autoregulator receptor protein BarB%2C 216 aa%3B fasta scores: opt: 565 Z-score: 645.4 bits: 126.6 E(): 2.3e-28%3B 48.980%25 identity in 196 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins gene gene6348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6286 SCO6287 SCO6287 SC1G7.13 SC1G7.13 6946617 6947423 + thioesterase II SC1G7.13%2C scoT thioesterase II%2C len: 268 aa%3B identical to previously sequenced TR:AAF43096 (EMBL:AF109727) Streptomyces coelicolor A3(2) thioesterase II ScoT%2C 268 aa. Contains Pfam match to entry PF00975 Thioesterase%2C Thioesterase domain gene gene6349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6287 SCO6288 SCO6288 SC1G7.14 SC1G7.14 6947584 6948414 + regulatory protein SCBAC8D1.01%2C probable regulatory protein%2C len: 276 aa%3B similar to SW:AC24_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhodin operon activatory protein actII-4%2C 255 aa%3B fasta scores: opt: 707 Z-score: 815.0 bits: 158.5 E(): 8.3e-38%3B 45.306%25 identity in 245 aa overlap~SC1G7.14%2C possible regulatory protein (fragment)%2C len: >35 aa%3B similar to TR:Q54494 (EMBL:AJ224512) Streptomyces nogalater activator SnoA%2C 665 aa%3B fasta scores: opt: 86 Z-score: 144.4 bits: 32.8 E(): 1.9%3B 45.455%25 identity in 33 aa overlap gene gene6350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6288 SCO6289 SCO6289 SCBAC8D1.02 SCBAC8D1.02 6948589 6949758 + oxidoreductase SCBAC8D1.02%2C probable oxidoreductase%2C len: 389 aa%3B similar to TR:Q9S2N6 (EMBL:AL109661) Streptomyces coelicolor oxidoreductase (fragment) SC6E10.01%2C 375 aa%3B fasta scores: opt: 440 Z-score: 452.7 bits: 92.5 E(): 1.3e-17%3B 31.980%25 identity in 394 aa overlap. Contains Pfam match to entry PF01266 DAO%2C D-amino acid oxidase and matches to Prosite entries PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00059 Zinc-containing alcohol dehydrogenases signature gene gene6351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6289 SCO6290 SCO6290 SCBAC8D1.03 SCBAC8D1.03 6949755 6950009 + hypothetical protein SCBAC8D1.03%2C hypothetical protein%2C len: 84 aa%3B highly similar to N-terminal part of SW:SOXA_RHIME (EMBL:AF055582) Rhizobium meliloti sarcosine oxidase alpha subunit (EC 1.5.3.1) SoxA%2C 987 aa%3B fasta scores: opt: 132 Z-score: 169.8 bits: 39.3 E(): 0.072l%3B 42.373%25 identity in 59 aa overlap. Contains Pfam match to entry PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains gene gene6352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6290 SCO6291 SCO6291 SCBAC8D1.04 SCBAC8D1.04 6950002 6951537 + oxidase SCBAC8D1.04%2C probable oxidase%2C len: 511 aa%3B similar to SW:OOXA_RHIME (EMBL:U66830) Rhizobium meliloti opine oxidase subunit A (EC 1.*.*.*) OxaA%2C 526 aa%3B fasta scores: opt: 519 Z-score: 515.9 bits: 105.1 E(): 3.8e-21%3B 31.638%25 identity in 531 aa overlap. Contains 3x degenerate repeat: ASPVSA gene gene6353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6291 SCO6292 SCO6292 SCBAC8D1.05 SCBAC8D1.05 6951534 6952430 + dihydropicolinate synthase SCBAC8D1.05%2C probable dihydropicolinate synthase%2C len: 298 aa%3B similar to SW:DAPA_RHIME (EMBL:AJ222715) Rhizobium meliloti dihydropicolinate synthase (EC 4.2.1.52) DapA%2C 300 aa%3B fasta scores: opt: 410 Z-score: 478.8 bits: 96.6 E(): 4.4e-19%3B 31.034%25 identity in 290 aa overlap. Contains Pfam match to entry PF00701 DHDPS%2C Dihydrodipicolinate synthetase family gene gene6354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6292 SCO6293 SCO6293 SCBAC8D1.06 SCBAC8D1.06 6952433 6953434 + hypothetical protein SCBAC8D1.06%2C conserved hypothetical protein%2C len: 333 aa%3B similar to TR:Q9I489 (EMBL:AE004555) Pseudomonas aeruginosa hypothetical protein PA1255%2C 344 aa%3B fasta scores: opt: 872 Z-score: 981.3 bits: 190.0 E(): 4.5e-47%3B 41.964%25 identity in 336 aa overlap and to TR:Q98F20 (EMBL:AP003003) Rhizobium loti proline racemase MLL3979%2C 333 aa%3B fasta scores: opt: 985 Z-score: 1108.1 E(): 4.4e-54%3B 46.951%25 identity in 328 aa overlap gene gene6355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6293 SCO6294 SCO6294 SCBAC8D1.07c SCBAC8D1.07c 6953679 6954470 - GntR family transcriptional regulator SCBAC8D1.07c%2C possible gntR-family regulatory protein%2C len: 263 aa%3B similar to TR:Q9ZBS9 (EMBL:AL034446) Streptomyces coelicolor gntR-family transcriptional regulator SC1A9.23%2C 273 aa%3B fasta scores: opt: 575 Z-score: 630.3 bits: 124.3 E(): 1.6e-27%3B 47.945%25 identity in 219 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family gene gene6356 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6294 SCO6295 SCO6295 SCBAC8D1.08 SCBAC8D1.08 6954616 6956604 + ABC transporter ATP-binding protein SCBAC8D1.08%2C possible ABC transporter ATP-binding protein%2C len: 662 aa%3B similar to TR:Q9KKV4 (EMBL:AE004426) Vibrio cholerae ABC transporter ATP-binding protein VCA0996%2C 619 aa%3B fasta scores: opt: 1081 Z-score: 1044.0 bits: 203.4 E(): 1.4e-50%3B 35.859%25 identity in 594 aa overlap. Contains Pfam matches to entries PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. Also contains 2x degenerate repeat: VDGDGRDDGDGR(D/R)D and possible hydrophobic membrane spanning regions at N-terminal domain gene gene6357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6295 SCO6296 SCO6296 SCBAC8D1.09c SCBAC8D1.09c 6956543 6957022 - hypothetical protein SCBAC8D1.09c%2C conserved hypothetical protein%2C len: 159 aa%3B similar to TR:Q9HTH9 (EMBL:AE004951) Pseudomonas aeruginosa hypothetical protein PA5385%2C 159 aa%3B fasta scores: opt: 363 Z-score: 448.1 bits: 89.1 E(): 2.3e-17%3B 40.764%25 identity in 157 aa overlap gene gene6358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6296 SCO6297 SCO6297 SCBAC8D1.10c SCBAC8D1.10c 6957019 6957975 - 3-hydroxyacyl-CoA dehydrogenase SCBAC8D1.10c%2C probable 3-hydroxyacyl-CoA dehydrogenase%2C len: 318 aa%3B similar to TR:Q9HTH8 (EMBL:AE004951) Pseudomonas aeruginosa probable 3-hydroxyacyl-CoA dehydrogenase PA5386%2C 321 aa%3B fasta scores: opt: 1055 Z-score: 1152.5 bits: 221.5 E(): 1.3e-56%3B 54.072%25 identity in 307 aa overlap. Contains Pfam matches to entries PF02737 3HCDH_N%2C 3-hydroxyacyl-CoA dehydrogenase%2C NAD binding domain and Pfam match to entry PF00725 3HCDH%2C 3-hydroxyacyl-CoA dehydrogenase%2C C-terminal domain gene gene6359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6297 SCO6298 SCO6298 SCBAC8D1.11c SCBAC8D1.11c 6957972 6958898 - hypothetical protein SCBAC8D1.11c%2C conserved hypothetical protein%2C len: 308 aa%3B similar to TR:Q9HTH7 (EMBL:AE004951) Pseudomonas aeruginosa hypothetical protein PA5387%2C 294 aa%3B fasta scores: opt: 1301 Z-score: 1431.2 bits: 272.9 E(): 3.9e-72%3B 64.746%25 identity in 295 aa overlap gene gene6360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6298 SCO6299 SCO6299 SCBAC8D1.12 SCBAC8D1.12 6958987 6959844 - TetR family transcriptional regulator SCIF3.01c%2C probable tetR-family transcriptional regulator%2C len: >248 aa%3B similar to TR:Q9XDV7 (EMBL:AB023642) Streptomyces griseus DNA-binding protein ORF2%2C 289 aa%3B fasta scores: opt: 847 z-score: 994.6 E(): 0%3B 65.3%25 identity in 245 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 28..49 (+3.30 SD)~SCBAC8D1.12c%2C possible DNA-binding protein (fragment)%2C len: >72 aa%3B similar to TR:Q9XDV7 (EMBL:AB023642) Streptomyces griseus DNA-binding protein ORF2%2C 289 aa%3B fasta scores: opt: 247 Z-score: 319.9 bits: 65.1 E(): 3.1e-10%3B 60.274%25 identity in 73 aa overlap gene gene6361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6299 SCO6300 SCO6300 SCIF3.02c SCIF3.02c 6959963 6961810 - hydrolase SCIF3.02c%2C probable hydrolase%2C len: 615 aa%3B similar to SW:HEXA_ALTSO (EMBL:D17399) Alteromonas sp. beta-hexosaminidase A precursor (EC 3.2.1.52) Cht60%2C 598 aa%3B fasta scores: opt: 565 z-score: 617.5 E(): 7.4e-27%3B 33.8%25 identity in 550 aa overlap and to TR:Q9RDG9 (EMBL:AL136519) Streptomyces coelicolor beta-N-acetylglucosaminidase NagA%2C 615 aa%3B fasta scores: opt: 2497 z-score: 2289.5 E(): 0%3B 65.6%25 identity in 605 aa overlap. Contains Pfam match to entry PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3 N terminal domain and PF01915 Glyco_hydro_3_C%2C Glycosyl hydrolase family 3 C terminal domain and match to Prosite entry PS00775 Glycosyl hydrolases family 3 active site. Also contains possible N-terminal region signal peptide sequence gene gene6362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6300 SCO6301 SCO6301 SCIF3.03c SCIF3.03c 6961931 6962080 - hypothetical protein SCIF3.03c%2C similar to part of TR:Q9K447 (EMBL:AL359216) Streptomyces coelicolor hypothetical 20.1 kDa protein%2C 181 aa%3B fasta scores: opt: 235 z-score: 338.0 E(): 2.7e-11%3B 72.3%25 identity in 47 aa overlap. Downstream of the cosmid there are two other CDS similar to contiguous parts of the same hypothetical protein gene gene6363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6301 SCO6302 SCO6302 SCIF3.04 SCIF3.04 6962111 6962281 + hypothetical protein SCIF3.04%2C unknown%2C len: 56 aa gene gene6364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6302 SCO6303 SCO6303 SCIF3.05c SCIF3.05c 6962349 6963320 - hydroxylase SCIF3.05c%2C conserved hypothetical protein%2C len: 323 aa%3B similar to TR:Q9X4X0 (EMBL:AF119621) Pseudomonas abietaniphila hypothetical protein which C-terminus is similar to isomerase/decarboxylase%2C DitH%2C 336 aa%3B fasta scores: opt: 481 z-score: 532.1 E(): 4.2e-22%3B 38.4%25 identity in 310 aa overlap. Contains Pfam match to entry PF01557 FAA_hydrolase%2C Fumarylacetoacetate (FAA) hydrolase family gene gene6365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6303 SCO6304 SCO6304 SCIF3.06c SCIF3.06c 6963368 6964300 - oxidoreductase SCIF3.06c%2C probable oxidoreductase%2C len: 310 aa%3B similar to SW:MPC2_ALCEU (EMBL:X52415) Alcaligenes eutrophus metapyrocatechase 2 (EC 1.13.11.2) McpII%2C 320 aa%3B fasta scores: opt: 301 z-score: 359.5 E(): 1.7e-12%3B 28.1%25 identity in 299 aa overlap. Contains Pfam match to entry PF01013 Extradiol_dioxy%2C Extradiol ring-cleavage dioxygenase gene gene6366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6304 SCO6305 SCO6305 SCIF3.07c SCIF3.07c 6964306 6965349 - hypothetical protein SCIF3.07c%2C conserved hypothetical protein%2C len: 347 aa%3B similar to TR:Q55861 (EMBL:D64004) Synechocystis sp. hypothetical 38.3 kDa protein SLR0619%2C 348 aa%3B fasta scores: opt: 416 z-score: 477.8 E(): 4.4e-19%3B 30.8%25 identity in 312 aa overlap gene gene6367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6305 SCO6306 SCO6306 SCIF3.08c SCIF3.08c 6965355 6966485 - hypothetical protein SCIF3.08c%2C possible oxidoreductase%2C len: 376 aa%3B similar to TR:AAG05975 (EMBL:AE004687) Pseudomonas aeruginosa probable FAD-dependent monooxygenase PA2587%2C 382 aa%3B fasta scores: opt: 443 z-score: 500.7 E(): 2.4e-20%3B 31.4%25 identity in 354 aa overlap. Contains Pfam match to entry PF01494 FAD_binding_3%2C FAD binding domain and PF01360 Monooxygenase%2C Monooxygenase gene gene6368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6306 SCO6307 SCO6307 SCIF3.09c SCIF3.09c 6966512 6967474 - cyclase SCIF3.09c%2C cyclase%2C len: 320 aa%3B similar to TRNEW:AAK64254 (EMBL:AF373840) hypothetical polyketide cyclase from nicotine degradation cluster of Arthrobacter nicotinovorans Plasmid pA01 (310 aa) fasta scores%3B opt: 394%2C Z-score: 442.9%2C E(): 4.9e-17%2C 31.000%25 identity (32.517%25 ungapped) in 300 aa overlap. gene gene6369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6307 SCO6308 SCO6308 SCIF3.10c SCIF3.10c 6967471 6968472 - hydrolase SCIF3.10c%2C possible hydrolase%2C len: 333 aa%3B similar to TR:Q9RJW4 (EMBL:AL117387) Streptomyces coelicolor 2-hydroxyhepta-2%2C4-diene-1%2C7-dioate isomerase SCF41.05%2C 292 aa%3B fasta scores: opt: 496 z-score: 573.9 E(): 2e-24%3B 36.3%25 identity in 311 aa overlap. Contains Pfam match to entry PF01557 FAA_hydrolase%2C Fumarylacetoacetate (FAA) hydrolase family gene gene6370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6308 SCO6309 SCO6309 SCIF3.11 SCIF3.11 6968600 6969571 + LysR family transcriptional regulator SCIF3.11%2C probable lysR-family transcriptional regulator%2C len: 323 aa%3B similar to SW:NOD2_RHITR (EMBL:L01272) Rhizobium tropici nodulation protein D2 NodD2%2C 314 aa%3B fasta scores: opt: 534 z-score: 620.6 E(): 5e-27%3B 34.7%25 identity in 314 aa overlap and to TR:CAC05670 (EMBL:Y19177) Streptomyces antibioticus transcriptional regulator%2C 308 aa%3B fasta scores: opt: 1769 z-score: 2038.8 E(): 0%3B 87.3%25 identity in 308 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and PF01046 NodD_C_term%2C NodD transcription activator carboxyl terminal region and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Also contains possible helix-turn-helix motif at residues 21..42 (+3.27 SD) gene gene6371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6309 SCO6310 SCO6310 SCIF3.12 SCIF3.12 6970033 6971376 + cytochrome P450 SCIF3.12%2C probable cytochrome P450%2C len: 447 aa%3B similar to SW:CPXG_STRSQ (EMBL:M31939) Streptomyces sp. cytochrome P450 105C1 (EC 1.14.-.-) ChoP%2C 381 aa%3B fasta scores: opt: 301 z-score: 318.8 E(): 3.2e-10%3B 28.8%25 identity in 386 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 gene gene6372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6310 SCO6311 SCO6311 SCIF3.13 SCIF3.13 6971557 6971979 + hypothetical protein SCIF3.13%2C possible integral membrane protein%2C len: 140 aa. Contains possible hydrophobic membrane spanning regions gene gene6373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6311 SCO6312 SCO6312 cprA cprA 6972028 6972675 - transcriptional regulator SCIF3.14c%2C cprA%2C transcriptional regulator%2C len: 215 aa%3B identical to previously sequenced TR:O66121 (EMBL:AB000384) Streptomyces coelicolor CprS%2C 215 aa. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 30..51 (+3.61 SD) gene gene6374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6312 SCO6313 SCO6313 SCIF3.15c SCIF3.15c 6972975 6974066 - hypothetical protein SCIF3.15c%2C possible integral membrane protein%2C len: 363 aa%3B highly similar to TR:Q9KY24 (EMBL:AL356892) Streptomyces coelicolor integral membrane protein SCC8A.24c%2C 380 aa%3B fasta scores: opt: 2130 z-score: 2459.4 E(): 0%3B 95.5%25 identity in 352 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6313 SCO6314 SCO6314 SCIF3.16c SCIF3.16c 6974063 6974673 - gene gene6376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6314 SCO6315 SCO6315 SCIF3.17c SCIF3.17c 6974828 6975044 - gene gene6377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6315 SCO6316 SCO6316 SCIF3.18 SCIF3.18 6975046 6975153 - hypothetical protein SCIF3.18. Similar to part of TR:Q9K447 (EMBL:AL359216) Streptomyces coelicolor hypothetical 20.1 kDa protein%2C 181 aa%3B fasta scores: opt: 192 z-score: 325.7 E(): 1.3e-10%3B 83.3%25 identity in 36 aa overlap. Upstream CDS similar to a contiguous part of the same hypothetical protein%2C but reading in the opposite orientation gene gene6378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6316 SCO6317 SCO6317 SCIF3.19 SCIF3.19 6975194 6975283 + hypothetical protein SCIF3.19. Similar to part of TR:Q9K447 (EMBL:AL359216) Streptomyces coelicolor hypothetical 20.1 kDa protein%2C 181 aa%3B fasta scores: opt: 169 z-score: 305.5 E(): 1.8e-09%3B 83.3%25 identity in 30 aa overlap. Upstream CDS similar to a contiguous part of the same hypothetical protein%2C but reading in the opposite orientation gene gene6379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6317 SCO6318 SCO6318 SCIF3.20c SCIF3.20c 6975868 6976440 - hypothetical protein SCIF3.20c%2C conserved hypothetical protein%2C len: 190 aa%3B similar to SW:TERD_ALCSP (EMBL:M20238) Alcaligenes sp. tellurium resistance protein TerD%2C 192 aa%3B fasta scores: opt: 204 z-score: 247.1 E(): 3.2e-06%3B 28.3%25 identity in 173 aa overlap and to TR:CAA18342 (EMBL:AL022268) Streptomyces coelicolor hypothetical protein SC4H2.27c%2C 202 aa%3B fasta scores: opt: 685 z-score: 748.3 E(): 0%3B 56.1%25 identity in 180 aa overlap. Contains Pfam match to entry PF02342 TerD gene gene6380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6318 SCO6319 SCO6319 SCIF3.21 SCIF3.21 6976852 6977634 + lipoprotein SCIF3.21%2C possible lipoprotein%2C len: 260 aa%3B similar to TR:Q9XAG2 (EMBL:AL079356) Streptomyces coelicolor possible membrane protein SC6G9.20%2C 303 aa%3B fasta scores: opt: 984 z-score: 1092.9 E(): 0%3B 58.5%25 identity in 287 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene6381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6319 SCO6320 SCO6320 SCIF3.22c SCIF3.22c 6977697 6979466 - transport integral membrane protein SCIF3.22c%2C possible transport integral membrane protein%2C len: 589 aa%3B similar to TR:O28857 (EMBL:AE001006) Archaeoglobus fulgidus chloride channel%2C AF1415%2C 589 aa%3B fasta scores: opt: 941 z-score: 956.9 E(): 0%3B 34.4%25 identity in 576 aa overlap. Contains Pfam match to entry PF00654 voltage_CLC%2C Voltage gated chloride channels and 2x PF00571 CBS%2C CBS domain. Also contains possible hydrophobic membrane spanning regions gene gene6382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6320 SCO6321 SCO6321 SCIF3.23 SCIF3.23 6980436 6981524 + hypothetical protein SCIF3.23%2C possible integral membrane protein%2C len: 362 aa%3B highly similar to TR:Q9KZX9 (EMBL:AL353815) Streptomyces coelicolor integral membrane protein SCD6.25%2C 362 aa%3B fasta scores: opt: 1695 z-score: 1862.4 E(): 0%3B 73.8%25 identity in 362 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6321 SCO6322 SCO6322 SCIF3.24 SCIF3.24 6982205 6982623 + gene gene6384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6322 SCO6323 SCO6323 SCIF3.25c SCIF3.25c 6983231 6983887 - TetR family transcriptional regulator SCIF3.25c%2C probable tetR-family regulatory protein%2C len: 218 aa%3B similar to TR:O66121 (EMBL:AB000384) Streptomyces coelicolor regulatory protein CprS%2C 215 aa%3B fasta scores: opt: 370 z-score: 471.3 E(): 1e-18%3B 36.1%25 identity in 191 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene6385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6323 SCO6324 SCO6324 SCIF3.26 SCIF3.26 6984273 6984983 + hydrolase SCIF3.26%2C possible hydrolase%2C len: 236 aa%3B similar to TR:CAC13072 (EMBL:AL445503) Streptomyces coelicolor hydrolase 2SCG38.13%2C 238 aa%3B fasta scores: opt: 320 z-score: 385.7 E(): 6e-14%3B 34.3%25 identity in 210 aa overlap. Contains Pfam match to entry PF00702 Hydrolase%2C haloacid dehalogenase-like hydrolase abd a TTA leucine codon%2C possible target for bldA regulation gene gene6386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6324 SCO6325 SCO6325 SC10H5.01c SC10H5.01c 6985856 6986764 - hypothetical protein SC10H5.01c%2C unknown%2C partial CDS%2C len >109 aa%3B possible integral membrane protein~SCIF3.27c%2C possible membrane protein (fragment)%2C len: >221 aa%3B similar to TR:Q9ZC02 (EMBL:AL033505) Streptomyces coelicolor hypothetical 52.3 kDa protein SC1E6.20c%2C 501 aa%3B fasta scores: opt: 245 z-score: 288.4 E(): 1.6e-08%3B 36.3%25 identity in 212 aa overlap gene gene6387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6325 SCO6326 SCO6326 SC10H5.02c SC10H5.02c 6986787 6987242 - hypothetical protein SC10H5.02c%2C probable integral membrane protein%2C len: 151 aa%3B similar to S. coelicolor hypothetical protein TR:O54194 (EMBL:AL021411) SC7H1.35 (155 aa)%2C fasta scores%3B opt: 431 z-score: 749.8 E(): 0%2C 53.5%25 identity in 114 aa overlap gene gene6388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6326 SCO6327 SCO6327 SC10H5.03c SC10H5.03c 6987274 6987738 - hypothetical protein SC10H5.03c%2C probable integral membrane protein%2C len: 154 aa. Contains possible hydrophobic membrane spanning regions gene gene6389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6327 SCO6328 SCO6328 SC10H5.04c SC10H5.04c 6987864 6988172 - hypothetical protein SC10H5.04c%2C membrane protein%2C len: 103 aa. Contains possible hydrophobic membrane spanning regions gene gene6390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6328 SCO6329 SCO6329 SC10H5.05 SC10H5.05 6988370 6988459 + hypothetical protein SC10H5.05%2C questionable ORF%2C len: 29 aa gene gene6391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6329 SCO6330 SCO6330 SC10H5.06 SC10H5.06 6988456 6989079 + hypothetical protein SC10H5.06%2C probable membrane protein%2C len: 207 aa%3B similar to S. coelicolor TR:O54192 SC7H1.33c (191 aa)%2C fasta scores%3B opt: 312 z-score: 355.2 E(): 1.6e-12%2C 36.8%25 identity in 182 aa overlap gene gene6392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6330 SCO6331 SCO6331 SC10H5.07 SC10H5.07 6989076 6990485 + hypothetical protein SC10H5.07%2C hypothetical protein%2C len: 469 aa%3B similar to TR:Q9XA23 (EMBL:AL079308) Streptomyces coelicolor hypothetical protein SCH69.11c%2C 509 aa%3B fasta scores: opt: 648 Z-score: 735.0 E(): 2.6e-33%3B 41.614%25 identityin 471 aa overlap gene gene6393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6331 SCO6332 SCO6332 SC10H5.08c SC10H5.08c 6990537 6990734 - hypothetical protein SC10H5.08c%2C unknown%2C len: 65 aa gene gene6394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6332 SCO6333 SCO6333 SC10H5.09c SC10H5.09c 6990876 6991409 - hypothetical protein SC3A7.01c%2C unknown%2C partial CDS%2C len: >68 aa~SC10H5.09c%2C probable integral membrane protein%2C partial CDS len: >143 aa%3B some similarity in C-terminus to S. coelicolor hypothetical protein TR:O54106 (EMBL:AL021529) SC10A5.15 (114 aa)%2C fasta scores%3B opt: 145 z-score: 233.8 E(): 9.2e-06%2C 33.3%25 identity in 81 aa overlap. Overlaps and extends SC3A7.01c gene gene6395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6333 SCO6334 SCO6334 SC3A7.02c SC3A7.02c 6991755 6994433 - transcriptional regulator SC3A7.02c%2C probable transcritional regulator%2C len: 892 aa%3B similar to e.g. MALT_ECOLI MalT regulatory protein (901 aa)%2C fasta scores%3B opt: 540 z-score: 495.9 E(): 2.3e-20%2C 26.2%25 identity in 936 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C helix-turn-helix motif from aa 848 to 869 (Score 1229%2C +3.37 SD) and Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 50.40%2C E-value 3.8e-11 gene gene6396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6334 SCO6335 SCO6335 SC3A7.03c SC3A7.03c 6994439 6995353 - hypothetical protein SC3A7.03c%2C questionable ORF%2C len: 304 aa%3B this ORF is not predicted as coding by positional base preference gene gene6397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6335 SCO6336 SCO6336 SC3A7.04 SC3A7.04 6995390 6996544 + hypothetical protein SC3A7.04%2C questionable ORF%2C len: 384 aa%3B this ORF is not predicted as coding by positional base preference gene gene6398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6336 SCO6337 SCO6337 SC3A7.05c SC3A7.05c 6996448 6997380 - transposase SC3A7.05c%2C probable transposase%2C len: 310 aa%3B similar to transposase ORF's from many IS3 type insertion sequences e.g. Corynebacterium glutamicum TR:Q46069 (EMBL:X69104) IS3 related insertion element ORF2 (298 aa)%2C fasta scores%3B opt: 610 z-score: 720.3 E(): 7.2e-33%2C 49.3%25 identity in 211 aa overlap gene gene6399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6337 SCO6338 SCO6338 SC3A7.06c SC3A7.06c 6997411 6997698 - transposase SC3A7.06c%2C probable transposase%2C len: 95 aa%3B similar to transposase ORF's from many IS3 type insertion sequences e.g. Corynebacterium glutamicum TR:Q46069 (EMBL:X69104) IS3 related insertion element ORF1 (97 aa)%2C fasta scores%3B opt: 244 z-score: 383.2 E(): 4.3e-14%2C 46.2%25 identity in 93 aa overlap. Contains probable coiled-coil from 55 to 93 and helix-turn-helix motif from aa 25-46 (Score 1789%2C +5.28 SD) gene gene6400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6338 SCO6339 SCO6339 SC3A7.07 SC3A7.07 6998012 6999361 + 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase SC3A7.07%2C probable 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase%2C len: 449 aa%3B Similar in N- and C- termini to Rhodococcus opacus TR:G2935027 (EMBL:EMBL%3B AF003947) 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (400 aa)%2C fasta scores%3B opt: 551 z-score: 916.0 E(): 0%2C 35.2%25 identity in 435 aa overlap. N-terminus (to 250aa) is similar to e.g. Acinetobacter calcoaceticus TR:Q59093 (EMBL:L05770) beta-ketoadipate enol-lactone hydrolase (266 aa)%2C fasta scores%3B opt: 445 z-score: 470.5 E(): 5.9e-19%2C 30.3%25 identity in 244 aa overlap. C-terminus (from 330 aa) is similar to e.g. DC4C_ACICA 4-carboxymuconolactone decarboxylase (134 aa)%2C fasta scores%3B opt: 409 z-score: 435.1 E(): 5.5e-17%2C 47.2%25 identity in 123 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha /beta hydrolase fold%2C score 62.50%2C E-value 8.9e-15 gene gene6401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6339 SCO6340 SCO6340 SC3A7.08 SC3A7.08 6999405 7000040 + hypothetical protein SC3A7.08%2C unknown%2C len: 211 aa%3B similar to hypothetical proteins e.g. S. coelicolor TR:O54167 (EMBL:AL021411) SC7H1.08C (202 aa)%2C fasta scores%3B opt: 243 z-score: 810.6 E(): 0%2C 43.8%25 identity in 210 aa overlap gene gene6402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6340 SCO6341 SCO6341 SC3A7.09 SC3A7.09 7000095 7000874 + exonuclease SC3A7.09%2C probable exonuclease%2C len: 259 aa%3B similar to exonuclease III from many organisms e.g. EX3_ECOLI exodeoxyribonuclease III (EC 3.1.11.2) (268 aa)%2C fasta scores%3B opt: 302 z-score: 443.2 E(): 2e-17%2C 33.5%25 identity in 266 aa overlap gene gene6403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6341 SCO6342 SCO6342 SC3A7.10 SC3A7.10 7000969 7001376 + hypothetical protein SC3A7.10%2C unknown%2C len: 135 aa gene gene6404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6342 SCO6343 SCO6343 SC3A7.11 SC3A7.11 7001411 7001539 + hypothetical protein SC3A7.11%2C questionable ORF%2C len: 42 aa gene gene6405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6343 SCO6344 SCO6344 SC3A7.12 SC3A7.12 7001616 7003223 - amidase SC3A7.12%2C probable amidase%2C len: 535 aa%3B similar to many (except N-terminal signal peptide sequence of this CDS) e.g. SW:GATA_STRCO (EMBL:AL035569) Streptomyces coelicolor glutamyl-tRNA(Gln) amidotransferase subunit A GatA or SC8D9.11%2C 497 aa%3B fasta scores: opt: 631 Z-score: 664.3 E(): 2.4e-29%3B 33.932%25 identity in 501 aa overlap. Contains N-terminal signal sequence gene gene6406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6344 SCO6345 SCO6345 SC3A7.13 SC3A7.13 7003454 7004212 + chitinase SC3A7.13%2C possible chitinase%2C len: 252 aa%3B Contains two regions separated by a Gly-Asp rich region from aa 171 to 197. The N-terminal region is similar to several chitin binding proteins and chitinases e.g. TR:Q54501 (EMBL:X78535) chitin binding protein precursor from Streptomyces olivaceoviridis (201 aa)%2C fasta scores%3B opt: 153 z-score: 311.6 E(): 4.2e-10%2C39.4%25 identity in 198 aa overlap%2C the short C-terminal region is similar to parts of many chitinases e.g. CHIA_ALTSO chitinase a precursor (820 aa)%2C fasta scores%3B opt: 152 z-score: 215.9 E(): 9e-05%2C 48.6%25 identity in 37 aa overlap. Contains N-terminal signal sequence. gene gene6407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6345 SCO6346 SCO6346 SC3A7.14 SC3A7.14 7004372 7004848 + hypothetical protein SC3A7.14%2C unknown%2C len: 158 aa gene gene6408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6346 SCO6347 SCO6347 SC3A7.15 SC3A7.15 7004952 7006739 + beta-galactosidase SC3A7.15%2C probable beta-galactosidase%2C len: 595%3B similar to many e.g. TR:O31341 (EMBL:D88750) beta-galactosidase (EC 3.2.1.23) (lactase) from Bacillus circulans (586 aa)%2C fasta scores%3B opt: 1648 z-score: 1500.8 E(): 0%2C 43.0%25 identity in 584 aa overlap.%2C Contains PS01182 Glycosyl hydrolases family 35 active site gene gene6409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6347 SCO6348 SCO6348 SC3A7.16c SC3A7.16c 7006807 7010892 - hypothetical protein SC3A7.16c%2C membrane protein%2C len: 1361 aa. Contains possible hydrophobic membrane spanning regions gene gene6410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6348 SCO6349 SCO6349 SC3A7.17 SC3A7.17 7011086 7012171 + transcriptional regulator SC3A7.17%2C probable transcriptional regulator%2C len: 361 aa%3B similar to many of the lacI family e.g. LACI_ECOLI lactose operon repressor (360 aa)%2C fasta scores%3B opt: 518 z-score: 705.7 E(): 4.6e-32%2C 33.6%25 identity in 339 aa overlap. Contains helix-turn-helix motif from aa 27-48 (Score 1760%2C +5.18 SD)%2C and Pfam matches to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C score 35.20%2C E-value 1.9e-08 and to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C score 78.80%2C E-value 1.1e-19 gene gene6411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6349 SCO6350 SCO6350 SC3A7.18c SC3A7.18c 7012204 7012788 - hypothetical protein SC3A7.18c%2C unknown%2C len: 194 aa gene gene6412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6350 SCO6351 SCO6351 SC3A7.19 SC3A7.19 7012868 7013566 + hypothetical protein SC3A7.19%2C unknown%2C len: 232 aa gene gene6413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6351 SCO6352 SCO6352 SC3A7.20c SC3A7.20c 7013618 7014034 - hypothetical protein SC3A7.20c%2C unknown%2C len: 138 aa gene gene6414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6352 SCO6353 SCO6353 SC3A7.21c SC3A7.21c 7014907 7016286 - two-component sensor SC3A7.21c%2C probable two-component sensor%2C len: 459 aa%3B similar to many e.g. COPS_PSESM sensor protein copS (EC 2.7.3.-) (487 aa)%2C fasta scores%3B opt: 310 z-score: 293.0 E(): 4.6e-09%2C 24.2%25 identity in 467 aa overlap. Contains a possible transmembrane domain near the N-terminus and Pfam match to entry PF00512 signal%2C Signal carboxyl-terminal domain%2C score 113.70%2C E-value 3.5e-30 gene gene6415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6353 SCO6354 SCO6354 SC3A7.22c SC3A7.22c 7016283 7016897 - two-component regulator SC3A7.22c%2C probable two-component regulator%2C len: 204 aa%3B similar to many e.g. CUTR_STRLI transcriptional regulatory protein CutR (217 aa)%2C fasta scores%3B opt: 386 z-score: 526.1 E(): 4.7e-22%2C 38.1%25 identity in 202 aa overlap. Contains Pfam matches to entry PF00486 trans_reg_C%2C Transcriptional regulatory proteins%2C C terminal%2C score 69.70%2C E-value 1.8e-19 and to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 45.60%2C E-value 1.1e-09 gene gene6416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6354 SCO6355 SCO6355 SC3A7.23c SC3A7.23c 7016899 7017717 - hypothetical protein SC3A7.23c%2C probable integral membrane protein%2C len: 272 aa. Contains possible hydrophobic membrane spanning regions gene gene6417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6355 SCO6356 SCO6356 SC3A7.24c SC3A7.24c 7017714 7018319 - hypothetical protein SC3A7.24c%2C probable integral membrane protein%2C len: 201 aa%3B some similarity to e.g. BCRC_BACLI bacitracin transport permease bcrC (203 aa)%2C fasta scores%3B opt: 203 z-score: 285.3 E(): 1.2e-08%2C 29.3%25 identity in 147 aa overlap gene gene6418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6356 SCO6357 SCO6357 SC3A7.25c SC3A7.25c 7018316 7019002 - hypothetical protein SC3A7.25c%2C membrane protein%2C len: 228 aa%3B similar to many hypothetical proteins beloning to the DedA family e.g. DEDA_ECOLI DedA protein (DSG-1 protein) (219 aa)%2C fasta scores%3B opt: 354 z-score: 391.7 E(): 1.4e-14%2C 34.2%25 identity in 199 aa overlap. Contains Pfam match to entry PF00597 DedA%2C DedA family%2C score 75.40%2C E-value 1.2e-18. Contains possible hydrophobic membrane spanning regions gene gene6419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6357 SCO6358 SCO6358 SC3A7.26 SC3A7.26 7019120 7019509 + hypothetical protein SC3A7.26%2C unknown%2C len: 129 aa%3B similar to hypothetical proteins from M. tuberculosis and M. leprae e.g. M. tuberculosis TR:O32909 (EMBL:Z83859) MTCY359.27 (142 aa)%2C fasta scores%3B opt: 201 z-score: 269.6 E(): 9.1e-08%2C 39.3%25 identity in 112 aa overlap gene gene6420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6358 SCO6359 SCO6359 SC3A7.27 SC3A7.27 7019506 7020435 + hypothetical protein SC3A7.27%2C possible integral membrane protein%2C len: 309 aa%3B similar to hypothetical proteins from M. tuberculosis and M. leprae e.g. M. tuberculosis TR:P95164 (EMBL:Z83859) MTCY359.28 (322 aa)%2C fasta scores%3B opt: 196 z-score: 298.4 E(): 2.3e-09%2C 33.7%25 identity in 267 aa overlap gene gene6421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6359 SCO6360 SCO6360 SC3A7.28 SC3A7.28 7020934 7021872 + ABC transporter ATP-binding protein SC3A7.28%2C probable ABC transporter ATP-binding protein%2C similar to many%2C e.g. BCRA_BACLI bacitracin transport ATP-binding protein bcrA (306 aa)%2C fasta scores%3B opt: 540 z-score: 640.6 E(): 2e-28%2C 34.9%25 identity in 298 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop) and Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 137.30%2C E-value 2.7e-37 gene gene6422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6360 SCO6361 SCO6361 SC3A7.29 SC3A7.29 7021869 7022708 + hypothetical protein SC3A7.29%2C probable integral membrane protein%2C len: 279 aa. Contains possible hydrophobic membrane spanning regions gene gene6423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6361 SCO6362 SCO6362 SC3A7.30 SC3A7.30 7022727 7024016 + two-component sensor SC3A7.30%2C probable two-component sensor%2C len: 429 aa%3B similar to many e.g. UHPB_SALTY sensor protein UhpB (500 aa)%2C fasta scores%3B opt: 238 z-score: 263.3 E(): 2.1e-07%2C 30.7%25 identity in 358 aa overlap. Contains six probable hydrophobic transmembrane domains in N-terminus gene gene6424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6362 SCO6363 SCO6363 SC3A7.31 SC3A7.31 7024013 7024681 + two-component regulator SC3A7.31%2C probable two-component regulator%2C len: 222 aa%3B similar to many e.g. DEGU_BACBR transcriptional regulatory protein DegU (236 aa)%2C fasta scores%3B opt: 437 z-score: 645.6 E(): 1e-28%2C 35.4%25 identity in 223 aa overlap. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature%2C helix-turn-helix motif at aa 173-194 (Score 1074%2C +2.84 SD) and Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 125.90%2C E-value 7.6e-34 and to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 70.00%2C E-value 5.1e-17 gene gene6425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6363 SCO6364 SCO6364 SC3A7.32c SC3A7.32c 7024745 7025536 - two-component regulator SC3A7.32c%2C probable two-component regulator%2C len: 263 aa%3B similar to many e.g. PHOP_BACSU alkaline phosphatase synthesis transcriptional regulator (240 aa)%2C fasta scores%3B opt: 452 z-score: 542.7 E(): 5.6e-23%2C 34.2%25 identity in 237 aa overlap. Contains Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 107.60%2C E-value 2.4e-28 and to entry PF00486 trans_reg_C%2C Transcriptional regulatory proteins%2C C terminal%2C score 58.80%2C E-value 3.3e-16 gene gene6426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6364 SCO6365 SCO6365 SC3A7.33c SC3A7.33c 7025526 7028168 - hypothetical protein SC4A2.01c%2C probable integral membrane protein%2C partial CDS%2C len: > 653 aa%3B overlaps and extends SC3A7.33c~SC3A7.33c%2C unknown%2C partial CDS%2C len: >259 aa gene gene6427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6365 SCO6366 SCO6366 SC4A2.02c SC4A2.02c 7028165 7028854 - ABC transporter ATP-binding protein SC4A2.02c%2C probable ABC transporter ATP-binding protein%2C len: 229 aa%3B similar to many e.g. CYSA_SYNP7 sulfate transport atp-binding protein cysA (344 aa)%2C fasta scores%3B opt: 422 z-score: 523.3 E(): 6.7e-22%2C 44.9%25 identity in 176 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and fam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 160.00%2C E-value 3.9e-44 gene gene6428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6366 SCO6367 SCO6367 SC4A2.03c SC4A2.03c 7028841 7029578 - ABC transporter ATP-binding protein SC4A2.03c%2C probable ABC transporter ATP-binding protein%2C len: 245 aa%3B similar to many e.g. YF08_METJA hypothetical ABC transporter ATP-binding protein (224 aa)%2C fasta scores%3B opt: 522 z-score: 604.9 E(): 1.9e-26%2C 40.6%25 identity in 219 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 175.60%2C E-value 8.3e-49 gene gene6429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6367 SCO6368 SCO6368 SC4A2.04c SC4A2.04c 7029575 7030195 - lipoprotein SC4A2.04c%2C probable lipoprotein%2C len: 206 aa%3B similar to TR:Q98E07 (EMBL:AP003004) Rhizobium loti (Mesorhizobium loti) lipoprotein MLR4460%2C 201 aa%3B fasta scores: opt: 472 Z-score: 495.8 E(): 5.6e-20%3B 40.933%25 identity in 193 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6368 SCO6369 SCO6369 SC4A2.05 SC4A2.05 7030354 7031664 + two-component sensor SC4A2.05%2C probable two-component sensor%2C len: 436 aa%3B similar to many e.g. CUTS_STRLI CtS protein (414 aa)%2C fasta scores%3B opt: 226 z-score: 309.1 E(): 5.8e-10%2C 32.9%25 identity in 316 aa overlap. Contains two probable transmembrane domains in the N-terminal half and Pfam matches to entry PF00672 DUF5%2C Domain found in bacterial signal proteins%2C score 42.70%2C E-value 8.2e-09 and to entry PF00512 signal%2C Signal carboxyl-terminal domain%2C score 38.00%2C E-value 1.7e-07 gene gene6431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6369 SCO6370 SCO6370 SC4A2.06c SC4A2.06c 7031672 7032706 - hypothetical protein SC4A2.06c%2C probable integral membrane protein%2C len: 344 aa%3B slight similarity to e.g. TR:O34524 (EMBL:AF027868) B. subtilis transporter yocS (321 aa)%2C fasta scores%3B opt: 141 z-score: 232.8 E(): 1e-05%2C 23.1%25 identity in 324 aa overlap gene gene6432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6370 SCO6371 SCO6371 SC4A2.07 SC4A2.07 7032798 7033637 + hypothetical protein SC4A2.07%2C probable integral membrane protein%2C len: 279 aa%3B similar to TR:Q98E10 (EMBL:AP003004) Rhizobium loti (Mesorhizobium loti) integral membrane protein MLR4456 309 aa%3B fasta scores: opt: 899 Z-score: 1025.7 E(): 1.7e-49%3B 56.126%25 identity in 253 aa overlap gene gene6433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6371 SCO6372 SCO6372 SC4A2.08 SC4A2.08 7033729 7033962 + hypothetical protein SC4A2.08%2C questionable ORF%2C len: 77 aa gene gene6434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6372 SCO6373 SCO6373 SC4A2.09 SC4A2.09 7034266 7035663 - hypothetical protein SC4A2.09%2C probable integral membrane protein%2C len: 465 aa. Contains possible hydrophobic membrane spanning regions gene gene6435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6373 SCO6374 SCO6374 SC4A2.10c SC4A2.10c 7035788 7037224 - sugar transferase SC4A2.10c%2C probable sugar transferase%2C len: 478%3B similar to many bacterial hypothetical proteins and to TR:O21943 (EMBL:AF021347) bactoprenol glucosyl transferase from bacteriophage SFII (309 aa)%2C fasta scores%3B opt: 809 z-score: 925.5 E(): 0%2C 40.9%25 identity in 303 aa overlap. Contains a C-terminal extension with four additional transmembrane domains not present in similar proteins and Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases%2C score 46.50%2C E-value 6.1e-10 gene gene6436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6374 SCO6375 SCO6375 SC4A2.11c SC4A2.11c 7037737 7038399 - hypothetical protein SC4A2.11c%2C probable hypothetical protein%2C len: 220 aa%3B similar to a set of Mycobacterial antigens e.g. MP83_MYCTU cell surface lipoprotein Mpt83 precursor (239 aa)%2C fasta scores%3B opt: 376 z-score: 505.8 E(): 6.4e-21%2C 35.6%25 identity in 222 aa overlap gene gene6437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6375 SCO6376 SCO6376 SC4A2.12 SC4A2.12 7038757 7039656 + hypothetical protein SC4A2.12%2C probable integral membrane protein%2C len: 299 aa gene gene6438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6376 SCO6377 SCO6377 SC4A2.13c SC4A2.13c 7039699 7041054 - lipoprotein SC4A2.13c%2C probable lipoprotein%2C len: 451 aa%3B contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6377 SCO6378 SCO6378 SC4A2.14c SC4A2.14c 7041611 7041910 - hypothetical protein SC4A2.14c%2C small hydrophobic protein%2C len: 99 aa%3B contains segment of similarity to BCRC_BACLI bacitracin transport permease BcrC (203 aa)%2C fasta scores%3B opt: 123 z-score: 260.1 E(): 3.1e-07%2C 60.6%25 identity in 33 aa overlap. Similar in parts to downstream ORF SC3A7.24c (57.0%25 identity in 114 aa overlap). Contains possible hydrophobic membrane spanning region gene gene6440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6378 SCO6379 SCO6379 SC4A2.15c SC4A2.15c 7042054 7042737 - hypothetical protein SC4A2.15c%2C membrane protein%2C len: 227 aa%3B similar to many members of the DedA family of hypothetical proteins e.g. DEDA_ECOLI DedA protein (DSG-1 protein) (219 aa)%2C fasta scores%3B opt: 375 z-score: 421.2 E(): 3.3e-16%2C 36.4%25 identity in 209 aa overlap. Highly similar to downstream ORF SC3A7.25c (78.9%25 identity in 213 aa overlap). Contains Pfam match to entry PF00597 DedA%2C DedA family%2C score 62.50%2C E-value 9e-15. Contains possible hydrophobic membrane spanning regions gene gene6441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6379 SCO6380 SCO6380 SC4A2.16c SC4A2.16c 7043084 7043440 - hypothetical protein SC4A2.16c%2C unknown%2C len: 118 aa gene gene6442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6380 SCO6381 SCO6381 SC4A2.17c SC4A2.17c 7043724 7045067 - lipoprotein SC4A2.17c%2C probable lipoprotein%2C len: 447 aa%3B contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6381 SCO6382 SCO6382 SC3C8.01 SC3C8.01 7046618 7047526 + hypothetical protein SC3C8.01%2C possible hypothetical protein%2C len: 302 aa%3B some similarity to M. tuberculosis lipoprotein YX36_MYCTU MTCY274.36 (343 aa)%2C fasta scores%3B opt: 201 z-score:255.1 E(): 5.7e-07%2C 24.9%25 identity in 257 aa overlap. Contains possible N-terminal signal sequence gene gene6444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6382 SCO6383 SCO6383 SC3C8.02c SC3C8.02c 7048443 7049126 - hypothetical protein SC3C8.02c%2C probable integral membrane protein%2C len: 227 aa gene gene6445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6383 SCO6384 SCO6384 SC3C8.03c SC3C8.03c 7049382 7051151 - integral membrane lysyl-tRNA synthetase SC3C8.03c%2C probable integral membrane lysyl-tRNA synthetase%2C len: 589 aa%3B similar to SW:P94974 (SYK2_MYCTU) probable lysyl-tRNA synthetase MTCY06H11.04C (1172 aa)%2C fasta scores%3B opt: 1426%2C z-score: 1642.9%2C E(): 0%2C 44.6%25 identity in 585 aa overlap. Contains TTA leucine codon%3B possible target for action of bldA gene gene6446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6384 SCO6385 SCO6385 SC3C8.04c SC3C8.04c 7051526 7053460 - hypothetical protein SC3C8.04c%2C probable integral membrane protein%2C len: 644 aa%3B similar to hypothetical proteins e.g. M. tuberculosis TR:O07192 (EMBL:Z96072) MTCY05A6.11C (647 aa)%2C fassta scores%3B opt: 916 z-score: 1168.8 E(): 0%2C 35.3%25 identity in 666 aa overlap. Also similar to S.coelicolor SC10A5.05 (E():0%2C 34.8%25 identity in 669 aa overlap) gene gene6447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6385 SCO6386 SCO6386 SC3C8.05 SC3C8.05 7053632 7054015 + hypothetical protein SC3C8.05%2C unknown%2C questionable ORF%2C len: 127 aa%3B contains TTA leucine codon%3B possible target for action of bldA gene gene6448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6386 SCO6387 SCO6387 SC3C8.06 SC3C8.06 7054118 7054684 + hypothetical protein SC3C8.06%2C questionable ORF%2C len: 188 aa%3B similar to the C-terminal regions of various transposases%2C e.g. TR:Q9FBV8 (EMBL:AL391338) Streptomyces coelicolor transposase SC8E7.24c%2C 549 aa%3B fasta scores: opt: 493 Z-score: 531.0 E(): 6e-22%3B 46.552%25 identity in 174 aa overlap. Contains TTA leucine codon%2C possible target for action of bldA gene gene6449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6387 SCO6388 SCO6388 SC3C8.07c SC3C8.07c 7054965 7055324 - hypothetical protein SC3C8.07c%2C unknown%2C len: 119 aa gene gene6450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6388 SCO6389 SCO6389 SC3C8.08c SC3C8.08c 7055321 7055713 - hypothetical protein SC3C8.08c%2C unknown%2C len: 130 aa gene gene6451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6389 SCO6390 SCO6390 SC3C8.09 SC3C8.09 7056189 7057292 + hypothetical protein SC3C8.09%2C probable integral membrane protein%2C len: 367 aa%3B similar to a hypothetical protein from M. tuberculosis Y07S_MYCTU MTCY02B10.28c (653 aa)%2C fatsta scores%3B opt: 144 z-score: 314.2 E(): 2.9e-10%2C 30.6%25 identity in 281 aa overlap. Also similar to S. coelicolor SC7H1.03c (E(): 3e-18%2C 35.2%25 identity in 355 aa overlap) gene gene6452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6390 SCO6391 SCO6391 SC3C8.10 SC3C8.10 7057809 7059026 + IS110 transposase/integrase SC3C8.10%2C probable IS110 transposase/integrase%2C len: 405 aa%3B identical to YIS1_STRCO insertion element IS110 hypothetical protein (405 aa). Similar to many e.g. YI11_STRCL S.clavuligerus IS116 encoded integrase/transposase (399 aa)%2C fasta scores%3B opt: 680 z-score: 854.2 E(): 0%2C 34.4%25 identity in 390 aa overlap. Also some similarity toPIV_MORBO pilin gene inverting protein (PIVML) (322 aa)%2C fasta scores%3B opt: 302 z-score: 369.5 E(): 2.4e-13%2C 29.5%25 identity in 237 aa overlap gene gene6453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6391 SCO6392 SCO6392 SC3C8.11c SC3C8.11c 7059104 7060243 - transposase SC3C8.11c%2C probable transposase%2C len: 379 aa%3B similar to many e.g. YIS1_STRCO insertion element IS110 hypothetical protein (405 aa)%2C fasta scores%3B opt: 239 z-score: 294.4 E(): 3.7e-09%2C 27.5%25 identity in 356 aa overlap. Contains probable coiled-coil from aa 214 to 249 gene gene6454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6392 SCO6393 SCO6393 SC3C8.12 SC3C8.12 7060375 7061838 + transposase SC3C8.12%2C probable transposase IS21/IS1162 family%2C len: 487 aa%3B similar to many e.g. TRA6_BACST transposase for insertion sequence element IS5376 (400 aa)%2C fasta scores%3B opt: 377 z-score: 617.9 E(): 3.6e-27%2C 29.9%25 identity in 351 aa overlap. Contains probable helix-turn-helix motif at aa 39 to 60 (Score 2208%2C +6.71 SD)) gene gene6455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6393 SCO6394 SCO6394 SC3C8.13 SC3C8.13 7061835 7062605 + IS element ATP binding protein SC3C8.13%2C probable IS element ATP binding protein (IS21/IS1162 family)%2C len: 256 aa%3B similar to e.g. ISTB_BACST insertion sequence IS5376 ATP-binding protein (251 aa)%2C fasta scores%3B opt: 741 z-score: 1114.9 E(): 0%2C 44.4%25 identity in 248 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene6456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6394 SCO6395 SCO6395 SC3C8.14 SC3C8.14 7063063 7065221 + gene gene6457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6395 SCO6396 SCO6396 SC3C8.15 SC3C8.15 7063621 7064501 + gene gene6458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6396 SCO6399 SCO6399 SC3C8.18c SC3C8.18c 7065214 7065729 - hypothetical protein SC3C8.18c%2C unknown%2C len: 171 aa gene gene6459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6399 SCO6400 SCO6400 SC3C8.19 SC3C8.19 7066309 7067553 + IS117 transposase SC3C8.19%2C probable transposase for IS117%2C len: 414 aa%3B identical to YM3_STRCO mini-circle hypothetical 45.7 kd protein (414 aa) and similar to many others e.g. YI11_STRCL insertion element IS116 hypothetical 44.8 kD protein (399 aa)%2C fasta scores%3B opt: 324 z-score: 416.9 E(): 5.6e-16%2C 27.4%25 identity in 413 aa overlap gene gene6460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6400 SCO6401 SCO6401 SC3C8.21c SC3C8.21c 7067605 7068132 - hypothetical protein SC3C8.21c%2C unknown ORF in IS117%2C len: 175 aa%3B identical to%2C but longer than%2C YM2_STRCO mini-circle hypothetical 13.3 KD protein (122 aa). Note alternative ORF on opposite strand. Contains TTA Leu codon%3B possible site for action of bldA gene gene6461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6401 SCO6402 SCO6402 SC3C8.20 SC3C8.20 7067650 7068003 + hypothetical protein SC3C8.20%2C unknown ORF in IS117%2C len: 117 aa%3B identical to YM1_STRCO mini-circle hypothetical 12.9 KD protein (117 aa). Note alternative ORF on opposite strand gene gene6462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6402 SCO6403 SCO6403 SC3C8.22c SC3C8.22c 7068218 7068598 - hypothetical protein SC3C8.22c%2C unknown%2C len: 126 aa gene gene6463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6403 SCO6404 SCO6404 SC3C8.23 SC3C8.23 7069255 7069434 + hypothetical protein SC3C8.23%2C unknown%2C len: 59 aa gene gene6464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6404 SCO6405 SCO6405 SC3C8.24 SC3C8.24 7069508 7071526 + DNA recombinase SC3C8.24%2C possible DNA recombinase%2C len: 672 aa%3B some similarity to CISA_BACSU DNA recombinase (500 aa)%2C fasta scores%3B opt: 139 z-score: 221.6 E(): 4.2e-05%2C 25.8%25 identity in 383 aa overlap%2C with stronger similarity around the conserved active site. Contains PS00397 Site-specific recombinases active site%2C Pfam match to entry recombinase PF00239%2C Site-specific recombinases%2C score 52.67 and probable coiled-coil from aa 391 to 428. Also similar to S. coelicolor prophage gene SC2E1.37 (E(): 0%2C 41.1%25 identity in 689 aa overlap) gene gene6465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6405 SCO6406 SCO6406 SC3C8.25c SC3C8.25c 7071396 7071791 - hypothetical protein SC3C8.25c%2C possible hypothetical protein%2C len: 131 aa%3B contains possible N-terminal signal sequence gene gene6466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6406 SCO6407 SCO6407 SC3C8.26 SC3C8.26 7071944 7073755 + gamma-glutamyltranspeptidase SC3C8.26%2C possible gamma-glutamyltranspeptidase ( hypothetical protein)%2C len: 603 aa%3B similar to many e.g. GGT_BACSU gamma-glutamyltranspeptidase precursor (EC 2.3.2.2) (587 aa)%2C fasta scores%3B opt: 705 z-score: 863.9 E(): 0%2C 36.9%25 identity in 591 aa overlap%2C and to PAC1_PSESV cephalosporin acylase I (EC 3.5.1.-) (557 aa)%2C fasta scores%3B opt: 377 z-score: 819.8 E(): 0%2C 34.1%25 identity in 569 aa overlap. Contains probable N-terminal signal sequence gene gene6467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6407 SCO6408 SCO6408 clpA clpA 7073756 7076284 - Clp protease ATP binding subunit SC3C8.27c%2C clpA%2C probable clp protease ATP binding subunit%2C len: 842 aa%3B highly similar to many e.g. CLPB_ECOLI clpB protein (857 aa)%2C fasta scores%3B opt: 975 z-score: 1914.6 E(): 0%2C 46.8%25 identity in 857 aa overlap anCLAB_LYCES ATP-dependent clp protease atp-binding subunit (923 aa)%2C fasta scores%3B opt: 2335 z-score: 2174.3 E(): 0%2C 50.3%25 identity in 758 aa overlap. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00870 and PS00871 Chaperonins clpA/B signatures 1 and 2%2C Pfam match to entry clpA_B PF00495%2C Chaperonins clpA/B%2C score 1127.99 and probable coiled-coil from aa 432 to 488 gene gene6468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6408 SCO6409 SCO6409 map2 map2 7076437 7077213 - methionine aminopeptidase SC3C8.28c%2C map2%2C probable methionine aminopeptidase%2C len: 258 aa%3B highly similar to many e.g. AMPM_BACSU methionine aminopeptidase (EC 3.4.11.18) (248 aa)%2C fasta scores%3B opt: 655 z-score: 833.0 E(): 0%2C 41.1%25 identity in 253 aa overlap. Also similar to S. coelicolor map TR:O54208 (EMBL:X83011) (SC6G4.02)%3B 46.8%25 identity in 267 aa overlap gene gene6469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6409 SCO6410 SCO6410 SC3C8.29 SC3C8.29 7077312 7077563 + DNA-binding protein SC3C8.29%2C possible DNA-binding protein%2C len: 83 aa%3B contains probable helix-turn-helix motif at aa 29 to 50 (Score 1589%2C +4.60 SD)) gene gene6470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6410 SCO6411 SCO6411 SC3C8.30 SC3C8.30 7077746 7078588 + hydrolase SC3C8.30%2C probable hydrolase%2C len: 280 aa%3B similar to e.g. BUP_RAT beta-ureidopropionase (EC 3.5.1.6) (beta-alanine synthase) (393 aa)%2C fasta scores%3B opt: 529 z-score: 700.2 E(): 9.2e-32%2C 37.2%25 identity in 296 aa overlap. Also highly similar to TR:E1292351 (EMBL:AL023496) hydrolase SC1A6.03%2C fasta scores%3B E(): 0%2C 72.1%25 identity in 280 aa overlap gene gene6471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6411 SCO6412 SCO6412 SC1A6.01 SC1A6.01 7078585 7079868 + aminotransferase SC1A6.01%2C probable aminotransferase%2C partial CDS%2C len: 190 aa%3B similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa)%2C fasta scores%3B opt: 315 z-score: 402.3 E(): 2.8e-15%2C 36.0%25 identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202%2C Aminotransferases class-III pyridoxal-phosphate%2C score 147.18~SC3C8.31%2C probable aminotransferase%2C partial CDS%2C len: > 270 aa%3B similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase family%2C e.g. ARGD_CORGL acetylornithine aminotransferase (389 aa)%2C fasta scores%3B opt: 202 z-score: 588.9 E(): 1.5e-25%2C 36.9%25 identity in 271 aa overlap. Contains Pfam match to entry aminotran_3 PF00202%2C Aminotransferases class-III pyridoxal-phosphate%2C score 171.39. Continues as SC1A6.01 gene gene6472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6412 SCO6413 SCO6413 SC1A6.02 SC1A6.02 7079908 7081521 + DNA-binding protein SC1A6.02%2C possible DNA-binding protein%2C len: 537 aa%3B some similarity to a regulator of polyketide gene expression from Streptomyces ambofaciens%3B TR:Q00509 (EMBL:X63451) srmR (604 aa)%2C fasta scores%3B opt: 160 z-score: 215.6 E(): 7e-05%2C 26.8%25 identity in 400 aa overlap. Contains probable helix-turn-helix motifat aa 486-507 (Score 1520%2C +4.36 SD) gene gene6473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6413 SCO6414 SCO6414 SC1A6.03 SC1A6.03 7081657 7082499 + hypothetical protein SC1A6.03%2C possible hydrolase%2C len: 280%3B similar to e.g. BUP_RAT Q03248 rattus norvegicus (rat). beta-ureidopropionase (393 aa)%2C fasta scores%3B opt: 530 z-score: 759.6 E(): 0%2C 36.6%25 identity in 279 aa overlap gene gene6474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6414 SCO6415 SCO6415 SC1A6.04 SC1A6.04 7082535 7083938 + phenylhydantoinase catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position gene gene6475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6415 SCO6416 SCO6416 SC1A6.05 SC1A6.05 7083950 7084972 + oxidoreductase SC1A6.05%2C unknown%2C len: 340 aa%3B some similarity to e.g. TR:Q49598 (EMBL:U31567) Methanopyrus kandleri N5%2CN10-methylenetetrahydromethanopterin reductase (349 aa)%2C fasta scores%3B opt: 207 z-score: 425.6 E(): 1.4e-16%2C 25.7%25 identityin 358 aa overlap gene gene6476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6416 SCO6417 SCO6417 SC1A6.06 SC1A6.06 7085067 7086635 + integral membrane transporter SC1A6.06%2C possible integral membrane transporter%2C len: 522 aa%3B some similarity to e.g. FUR4_YEAST P05316 saccharomyces cerevisiae uracil permease (633 aa)%2C fasta sores%3B opt:478 z-score: 454.0 E(): 3.6e-18%2C 28.2%25 identity in 485 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature gene gene6477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6417 SCO6418 SCO6418 SC1A6.07c SC1A6.07c 7086736 7088364 - hypothetical protein SC1A6.07c%2C unknown%2C len: 813 gene gene6478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6418 SCO6419 SCO6419 SC1A6.08c SC1A6.08c 7088518 7089174 - hypothetical protein SC1A6.08c%2C unknown%2C len: 218 aa gene gene6479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6419 SCO6420 SCO6420 SC1A6.09c SC1A6.09c 7089432 7090445 - DNA-binding protein SC1A6.09c%2C unknown%2C len: 337 aa%3B similar to M. tuberculosis hypothetical protein TR:O06218 (EMBL:O06218) MTCY270.09 (344 aa)%2C fasta scores%3B opt: 632 z-score: 560.4 E(): 4.3e-24%2C 38.1%25 identity in 341 aa overlap. Contains possible helix-turn-helix motif at aa 23-44 (Score 987%2C +2.55 SD) gene gene6480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6420 SCO6421 SCO6421 SC1A6.10 SC1A6.10 7090613 7091761 + two-component system sensor kinase SC1A6.10%2C probable two-component system sensor kinase%2C len: 382 aa%3B N-terminus (~~1-150 aa) contains six potential transmembrane domains%2C C-terminus is similar to e.g. SW:UHPB_ECOLI (P09835) Escherichia coli sensor protein UhpB (500 aa)%2C fasta scores%3B opt: 151 z-score: 290.1 E(): 4.9e-09%2C 28.3%25 identity in 314 aa overlap and to many Streptomyces coelicolor two-component system sensor kinases%2C e.g. TR:Q9S2S0 (EMBL:AL09687) two-component system sensor kinase SC5F7.35c%2C 416 aa%3B fasta scores: opt: 525 Z-score: 546.5 E(): 8.3e-23%3B 40.489%25 identity in 368 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6421 SCO6422 SCO6422 SC1A6.11 SC1A6.11 7091758 7092432 + two-component system regulatory protein SC1A6.11%2C probable two-component system regulatory protein%2C len: 224 aa%3B similar to members of the luxR/uhpA family e.g. DEGU_BACSU P13800 transcriptional regulatory protein DegU (229 aa)%2C fasta scores%3B opt: 330 z-score: 706.1 E(): 3.3e-32%2C 36.7%25 identity in 226 aa overlap. Contains Pfam matches to entry response_reg PF00072%2C Response regulator receiver domain%2C score 149.95%2C and to entry GerE PF00196%2C Bacterial regulatory proteins%2C luxR family%2C score 89.64 gene gene6482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6422 SCO6423 SCO6423 SC1A6.12c SC1A6.12c 7092451 7093617 - lipoate-protein ligase SC1A6.12c%2C lipoate-protein ligase%2C len: 388 aa%3B some similarity inC-terM to LPLA_ECOLI P32099 Escherichia coli lipoate-protein ligase A (337 aa)%2C fasta scores%3B opt: 162 z-score: 223.4E(): 2.5e-05%2C 27.8%25 identity in 252 aa overlap gene gene6483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6423 SCO6424 SCO6424 SC1A6.13c SC1A6.13c 7093614 7094609 - two-component system sensor protein SC1A6.13c%2C probable two-component system sensor protein%2C len: 331 aa%3B contains two potential transmembrane domains in the C-terminus%3B similar to e.g. DEGS_BACSU P13799 sensor protein DegS (EC 2.7.3.-) Bacillus subtilis (385 aa)%2C fasta scores: opt: 316 z-score: 369.3 E(): 1.9e-13%2C 30.7%25 identity in 212 aa overlap and to TR:Q52558 (EMBL:U02041) Burkholderia solanacearum VrsA%2C 502 aa%3B fasta scores: opt: 398 Z-score: 416.9 E(): 1.4e-15%3B 31.724%25 identity in 290 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6424 SCO6425 SCO6425 SC1A6.14 SC1A6.14 7094757 7095527 + hypothetical protein SC1A6.14%2C probable transcriptional regulator%2C len: 256 aa%3B weak similarity to e.g. RHAR_ECOLI P09378 Escherichia coli L-rhamnose operon transcriptional regulator RhaR (312 aa)%2C opt: 160 z-score: 207.2 E(): 0.0002%2C 29.5%25 identity in 105 aa overlap. Contains PS00041 Bacterial regulatory proteins%2C araC family signature%2C Pfam match to entry HTH_2 PF00165%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C score 65.61%2C and probable helix-turn-helix motif at aa 174-195 (Score 1532%2C +4.40 SD) gene gene6485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6425 SCO6426 SCO6426 SC1A6.15 SC1A6.15 7095676 7096188 + hypothetical protein SC1A6.15%2C unknown%2C len: 170 aa%3B similar to the C-terminus of several ABC transporter ATP binding proteins involved in iron transport%2C e.g. FEPC_ECOLI P23878 Escherichia coli ferric enterobactin transport ATP binding protein (271 aa)%2C fasta scores%3B opt: 237 z-score: 425.9 E(): 1.3e-16%2C 38.7%25 identity in 106 aa overlap gene gene6486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6426 SCO6427 SCO6427 SC1A6.16 SC1A6.16 7096185 7097480 + integral membrane transport protein SC1A6.16%2C probable integral membrane transport protein%2C len: 431 aa%3B weak similarity to e.g. Mycobacterium smegmatis TR:O31137 (EMBL:O31137) tetracycline-resistance determinant tetV (419 aa)%2C fasta scores%3B opt: 389 z-score: 243.8 E(): 1.9e-06%2C 27.0%25 identity in 404 aa overlap gene gene6487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6427 SCO6428 SCO6428 SC1A6.17c SC1A6.17c 7097567 7104511 - hypothetical protein SC1A6.17c%2C possible hypothetical protein%2C len: 2314 aa%3B has short segment of similarity to acid phosphatases e.g. PHOC_MORMO P28581 morganella morganii acid phosphatase (249aa)%2C fasta scores%3B opt: 251 z-score: 206.3 E(): 0.00023%2C 32.1%25 identity in 162 aa overlap and to TR:CAC37553 (EMBL:AL590983) Streptomyces coelicolor conserved hypothetical protein (fragment) SCBAC1C11.07c%2C 676 aa%3B fasta scores: opt: 490 Z-score: 458.2E(): 6.9e-18%3B 26.124%25 identity in 712 aa overlap. Contains possible N-terminalsignal sequence and PS01157 Class A bacterial acid phosphatases signature gene gene6488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6428 SCO6429 SCO6429 SC1A6.18 SC1A6.18 7104902 7106290 + hypothetical protein SC1A6.18%2C unknown%2C len: 462 aa%3B some similarity to a hypothetical proteins from Streptomyces hygroscopicus TR:Q54310 (EMBL:X86780) ORFE from gene cluster for polyketide immunosuppressant rapamycin (465 aa)%2C fatsa scores%3B opt: 306 z-score: 225.9 E(): 1.8e-05%2C 28.3%25 identity in 441 aa overlap gene gene6489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6429 SCO6430 SCO6430 SC1A6.19 SC1A6.19 7106284 7108176 + hypothetical protein SC1A6.19%2C possible integral membrane protein%2C len: 630 aa%3B N-terminus (start to aa ~~400) is hydrophobic%2C C-terminus is proline-rich gene gene6490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6430 SCO6431 SCO6431 SC1A6.20 SC1A6.20 7108264 7111779 + peptide synthase SC1A6.20%2C probable peptide synthase%2C len: 1171 aa%3B similar to many e.g. TR:Q44103 (EMBL:X97860) Amycolatopsis mediterranei aps gene for peptide synthetase (1324 aa)%2C fasta scores%3B opt: 379 z-score: 1175.7 E(): 0%2C 32.3%25 identity in 993 aa overlap. Contains PS00455 AMP-binding domain signature%2C PS00012 Phosphopantetheine attachment site and Pfam match to entry AMP-binding PF00501%2C AMP-binding enzymes%2C score 421.02 gene gene6491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6431 SCO6432 SCO6432 SC1A6.21 SC1A6.21 7111866 7116089 + peptide synthase SC1A6.21%2C probable peptide synthase%2C len: 1407 aa%3B similar to many e.g. TR:Q54959 (EMBL:X98690) Streptomyces pristinaespiralis Pristinamycin I synthase 2 (2591 aa)%2C fasta scores%3B opt: 743 z-score: 754.8 E(): 0%2C 33.1%25 identity in1298 aa overlap. Contains PS00455 AMP-binding domain signature%2C PS00012 Phosphopantetheine attachment site%2C PS00120 Lipases%2C serine active site and Pfam match to entry AMP-binding PF00501%2C AMP-binding enzymes%2C score 430.73 gene gene6492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6432 SCO6433 SCO6433 SC1A6.22 SC1A6.22 7116086 7116493 + hypothetical protein SC1A6.22%2C unknown%2C len: 135 aa gene gene6493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6433 SCO6434 SCO6434 SC1A6.23 SC1A6.23 7116513 7117874 + oxidoreductase SC9B5.01%2C partial CDS%2C probable oxidoreductase%2C len: 353aa%3B overlaps with and forms the C-terminus of TR:O69828 on overlapping cosmid 1A6%2C similar to several eg. SW:PVDA_BURCE L-ornithine 5-monooxygenase from Burkholderia cepacia (444 aa) fasta scores%3B opt: 641%2C z-score: 580.6%2C E(): 4.7e-25%2C(40.5%25 identity in 316 aa overlap).~SC1A6.23%2C probable oxidoreductase%2C partial CDS%2C len: 133 aa%3B overlaps and forms the N-terminus of SC9B5.01 on overlapping cosmid 9B5%2C highly similar to an E. coli plasmid gene involved in siderophore biosynthesis IUCD_ECOLI P11295 Escherichia coli plasmid COLV-K30%2C lysine N-hydroxlyase (426 aa)%2Cfasta scores%3B opt: 298 z-score: 548.9 E(): 1.9e-23%2C 43.5%25 identity in 108 aa overlap gene gene6494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6434 SCO6435 SCO6435 SC9B5.02 SC9B5.02 7117871 7118257 + hypothetical protein SC9B5.02%2C unknown%2C len: 128 aa%3B similar to SW:WH16_STRCO 16.7kD protein in whiE locus of Streptomyces coelicolor (157 aa) fasta scores%3B opt: 199%2C z-score: 252.3%2C E(): 9.3e-07%2C (31.2%25 identity in 125 aa overlap). gene gene6495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6435 SCO6436 SCO6436 SC9B5.03 SC9B5.03 7118254 7119774 + tRNA synthetase SC9B5.03%2C probable tRNA synthetase%2C len: 506 aa%3B similar to many eg. SW:SYM_METTH methionyl-tRNA synthetase from Methanobacterium thermoautotrophicum (651 aa) fasta scores%3B opt: 610%2C z-score: 560.9%2C E(): 5.9e-24%2C (28.9%25 identity in 402 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. gene gene6496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6436 SCO6437 SCO6437 SC9B5.04 SC9B5.04 7119848 7121122 + hypothetical protein SC9B5.04%2C unknown%2C len: 424 aa%3B similar to two hypothetical proteins SW:Y4RH_RHISN from Rhizobium sp. fasta scores%3B opt: 213%2C z-score: 366.1%2C E(): 4.2e-13%2C (26.3%25 identity in 335 aa overlap) and SW:YWFE_BACSU from Bacillus subtilis (472 aa) fasta scores%3B opt: 217%2C z-score: 289.2%2C E(): 8.1e-09%2C (29.4%25 identity in 364 aa overlap). Also weakly similar to carbomylphosphate synthetases eg. TR:O50302 (EMBL:AJ001805) carbomylphosphate synthetase large subunit from Bacillus subtilis (1064 aa) fasta scores%3B opt: 150%2C z-score: 196.8%2C E(): 0.0011%2C (25.8%25 identity in 295 aa overlap). gene gene6497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6437 SCO6438 SCO6438 SC9B5.05 SC9B5.05 7121125 7122447 + diaminopimelate decarboxylase catalyzes the decarboxylation of diaminopimelate into lysine%3B pyridoxal phosphate(PLP)-binding gene gene6498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6438 SCO6439 SCO6439 SC9B5.06c SC9B5.06c 7122416 7122904 - DNA-binding protein SC9B5.06c%2C possible DNA-binding protein%2C len: 162 aa%3B similar in parts to many eukaryotic Y-box binding proteins (cold shock proteins) eg. SW:YB1_CHICK Y-box binding protein from Gallus gallus (chicken) (321 aa) fasta scores%3B opt: 165%2C z-score: 278.2%2C E(): 3.3e-08%2C (34.9%25 identity in 106 aa overlap) and TR:O53883 (EMBL:AL022004) proposed cold shock protein B from Mycobacterium tuberculosis (135 aa) fasta scores%3B opt: 174%2C z-score: 248.0%2C E(): 1.6e-06%2C (34.4%25 identity in 96 aa overlap). Contains Pfam match to entry PF00313 CSD%2C 'Cold-shock' DNA-binding domain. gene gene6499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6439 SCO6440 SCO6440 SC9B5.07 SC9B5.07 7123131 7123883 + hypothetical protein SC9B5.07%2C conserved hypothetical protein%2C len: 250aa%3B similar to 3 eg. SW:YA99_METJA hypothetical protein MJ1099 from Methanococcus jannaschii (235 aa) fasta scores%3Bopt: 848%2C z-score: 1229.1%2C E(): 0%2C (57.9%25 identity in 233 aa overlap). gene gene6500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6440 SCO6441 SCO6441 SC9B5.08 SC9B5.08 7123886 7125292 + aldehyde dehydrogenase SC9B5.08%2C probable aldehyde dehydrogenase%2C len: 468aa%3B similar to many eg. TR:O86742 (EMBL:AL031035) from Streptomyces coelicolor (479 aa) fasta scores%3B opt: 917%2C z-score: 901.0%2C E(): 0%2C (36.9%25 identity in 450 aa overlap) and SW:FEAB_ECOLI phenylacetaldehyde dehydrogenase from Escherichia coli (499 aa) fasta scores%3B opt: 799%2C z-score: 841.1%2C E(): 0%2C (38.7%25 identity in 465 aa overlap). Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase%2C PS00070 Aldehyde dehydrogenases cysteine active site and PS00687 Aldehyde dehydrogenases glutamic acid active site. gene gene6501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6441 SCO6442 SCO6442 SC9B5.09 SC9B5.09 7125293 7126396 + alcohol dehydrogenase SC9B5.09%2C probable alcohol dehydrogenase%2C len: 367aa%3B similar to many eg. SW:XYLB_PSEPU aryl-alcohol dehydrogenase from Pseudomonas putida (366 aa) fasta scores%3B opt: 928%2C z-score: 888.5%2C E(): 0%2C (42.6%25 identity in 366 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene6502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6442 SCO6443 SCO6443 SC9B5.10 SC9B5.10 7126477 7127388 + hypothetical protein SC9B5.10%2C conserved hypothetical protein%2C len: 303aa%3B similar to many hypothetical proteins e.g. TR:O86359 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (314 aa) fasta scores%3B opt: 464%2C z-score: 847.2%2C E(): 0%2C (36.7%25 identity in 313 aa overlap). Contains possible N-terminal signal sequence gene gene6503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6443 SCO6444 SCO6444 SC9B5.11 SC9B5.11 7127464 7129407 + gamma-glutamyl transferase SC9B5.11%2C probable gamma-glutamyl transferase%2C len: 647 aa%3B similar to many gamma-glutamyl transferases eg. TR:Q54353 (EMBL:X79146) LmbA%2C gamma-glutamyl transferase involved in lincomycin production in Streptomyces lincolnensis 78-11 (601 aa) fasta scores%3B opt: 871%2C z-score: 1756.8%2C E(): 0%2C (48.1%25 identity in 619 aa overlap). Also similar to TR:O54174 (EMBL:AL021411) probable transferase (606aa) from Streptomyces coelicolor fasta scores: opt: 953%2C z-score: 1203.1%2C E(): 0%2C (53.7%25 identity in 635 aa overlap). Contains Pfam match to entry PF01019 G_glu_transpept%2C Gamma-glutamyltranspeptidase gene gene6504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6444 SCO6445 SCO6445 SC9B5.12 SC9B5.12 7129505 7130350 + inositol monophosphatase SC9B5.12%2C probable inositol monophosphatase%2C len: 281aa%3B similar to many eg. SW:MYO3_LYCES myo-inositol-1(or 4)-monophosphatase 3 from Lycopersicon esculentum (tomato) (268 aa) fasta scores%3B opt: 286%2C z-score: 396.1%2C E(): 9e-15%2C (30.9%25 identity in 275 aa overlap). Contains PS00629 Inositol monophosphatase family signature 1 and PS00630 Inositol monophosphatase family signature 2. Contains 2x Pfam match to entry PF00459 inositol_P%2C Inositol monophosphatase family. gene gene6505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6445 SCO6446 SCO6446 SC9B5.13 SC9B5.13 7130387 7131346 + hypothetical protein SC9B5.13%2C unknown%2C len: 319aa. gene gene6506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6446 SCO6447 SCO6447 SC9B5.14c SC9B5.14c 7131401 7132141 - NAD(P)H oxidoreductase SC9B5.14c%2C possible NAD(P)H oxidoreductase%2C len: 246aa%3B similar to many (prokaryotic and eukaryotic) eg. SW:DHQV_HUMAN NAD(P)H dehydrogenase from Homo sapiens (human) (231 aa) fasta scores%3B opt: 182%2C z-score: 338.0%2C E(): 1.6e-11%2C (30.9%25 identity in 181 aa overlap). gene gene6507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6447 SCO6448 SCO6448 SC9B5.15 SC9B5.15 7132189 7133130 + AraC-like transcriptional regulator SC9B5.15%2C AraC-like transcriptional regulator%2C len: 313aa%3B similar to many members of the AraC family of transcriptional regulators eg. SW:MMSR_PSEAE mmsAB operon regulatory protein (307 aa) fasta scores%3B opt: 171%2C z-score: 257.7%2C E(): 4.6e-07%2C (34.6%25 identity in 78 aa overlap). Contains PS00041 Bacterial regulatory proteins%2C araC family signature and Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. gene gene6508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6448 SCO6449 SCO6449 SC9B5.16 SC9B5.16 7133229 7134647 + dehydrogenase SC9B5.16%2C possible dehydrogenase%2C len: 472 aa%3B similar to many%2C almost identical to SW:P49_STRLI P49 protein from Streptomyces lividans (469 aa) fasta scores%3B opt: 3162%2C z-score: 3290.5%2C E(): 0%2C (99.1%25 identity in 469 aa overlap). Also similar to SW:CRTI_RHOCA phytoene dehydrogenase from Rhodobacter capsulatus (524 aa) fasta scores%3B opt: 169%2C z-score: 305.6%2C E(): 9.8e-10%2C (25.0%25 identity in 509 aa overlap). Contains possible hydrophobic membrane spanning region gene gene6509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6449 SCO6450 SCO6450 SC9B5.17 SC9B5.17 7134644 7135153 + hypothetical protein SC9B5.17%2C conserved hypothetical protein%2C len: 169 aa%3B similar to several hypothetical proteins eg. TR:Q44020 (EMBL:L36817) hypothetical protein from Alcaligenes eutrophus (173 aa) fasta scores%3B opt: 482%2C z-score: 757.7%2C E(): 0%2C (50.6%25 identity in 174 aa overlap). Also similar to TR:O75377 (EMBL:AF044286) histone macro 2A1.1 from Homo sapiens (369 aa) fasta scores%3B opt: 256%2C z-score: 321.4%2C E(): 1.3e-10%2C (29.4%25 identity in 170 aa overlap) gene gene6510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6450 SCO6451 SCO6451 SC9B5.18 SC9B5.18 7135277 7136905 + substrate binding protein SC9B5.18%2C probable substrate binding protein%2C len: 467aa%3B First of a five gene operon probably involved in peptide uptake. Very similar to SW:XP55_STRLI protein precursor of XP55%2C a major hypothetical protein from Streptomyces lividans (542 aa) fasta scores: opt: 3353%2C z-score: 2613.8%2C E(): 0%2C (95.9%25 identity in 532 aa overlap). Also similar to many substrate binding /transport proteins eg. SW:APPA_BACSU AppA oligopeptide-binding protein precursor from Bacillus subtilis (543 aa) fasta scores: opt: 717%2C z-score: 518.2%2C E(): 1.4e-21%2C (28.7%25 identity in 550 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS01040 Bacterial extracellular solute-binding proteins%2C family 5 signature. Also contains Pfam match to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5. gene gene6511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6451 SCO6452 SCO6452 SC9B5.19 SC9B5.19 7136902 7137906 + transport permease SC9B5.19%2C probable transport permease%2C len: 334aa%3B second of a five gene operon probably involved in peptide uptake%2C similar to many transport permeases eg. SW:DPPB_ECOLI DppB%2C dipeptide transport system permease from Escherichia coli (339 aa) fasta scores: opt: 362%2C z-score: 742.8%2C E(): 0%2C (32.9%25 identity in 340 aa overlap). gene gene6512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6452 SCO6453 SCO6453 SC9B5.20 SC9B5.20 7137903 7138841 + transport permease SC9B5.20%2C probable transport permease%2C len: 312aa%3B third of a five gene operon probably involved in peptide uptake%2C similar to many transport permeases eg. SW:APPC_BACSU oligopeptide transport permease%2C AppC from Bacillus subtilis (303 aa) fasta scores: opt: 643%2C z-score: 780.7%2C E(): 0%2C (36.6%25 identity in 295 aa overlap). Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene6513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6453 SCO6454 SCO6454 SC9B5.21 SC9B5.21 7138838 7139845 + ABC transporter ATP-binding protein SC9B5.21%2C probable ABC transporter ATP-binding protein%2C len: 335aa%3B fourth of a five gene operon probably involved in peptide uptake%2C similar to many eg. SW:DPPD_BACSU dipeptide transport ATP-binding protein%2C DppD%2C from Bacillus subtilis (335 aa) fasta scores: opt: 486%2C z-score: 654.6%2C E(): 3.6e-29%2C (37.6%25 identity in 348 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop). Also contains Pfam match to entry PF00005 ABC_tran%2C ABC transporters. gene gene6514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6454 SCO6455 SCO6455 SC9B5.22 SC9B5.22 7139838 7140506 + ABC transporter ATP-binding protein SC9B5.22%2C probable ABC transporter ATP-binding protein%2C len: 222aa%3B fifth of a five gene operon probably involved in peptide uptake%2C similar to many eg. SW:OPPF_SALTY oligopeptide transport ATP-binding protein%2C OppF%2C from Salmonella typhimurium (334 aa) fasta scores: opt: 412%2C z-score: 569.7%2C E(): 1.9e-24%2C (35.1%25 identity in 194 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop). Also contains Pfam match to entry PF00005 ABC_tran%2C ABC transporters. gene gene6515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6455 SCO6456 SCO6456 SC9B5.23c SC9B5.23c 7140529 7141923 - hydrolytic protein SC9B5.23c%2C probable hydrolytic protein%2C len: 464aa%3B similar to many eg. SW:ABFB_STRLI alpha-l-arabinofuranosidase precursor from Streptomyces lividans (478 aa) fasta scores: opt: 323%2C z-score: 291.1%2C E(): 6.4e-09%2C (37.9%25 identity in 132 aa overlap). Contains Pfam match to entry PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain. Contains possible hydrophobic membrane spanning region gene gene6516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6456 SCO6457 SCO6457 SC9B5.24 SC9B5.24 7142206 7146129 + beta-galactosidase SC9B5.24%2C lacZ*%2C beta-galactosidase%2C len: 1307 aa%3B similar to many e.g. TR:O85167 (EMBL:AF047824) beta-galactosidase from Bacillus megaterium (1034 aa) fasta scores: opt: 1750%2C z-score: 2221.6%2C E(): 0%2C (37.4%25 identity in 1256 aa overlap). Note that this CDS is approx. 300 residues longer than the homologues due to an extra region around residues 600 to 900. Contains PS00719 Glycosyl hydrolases family 2 signature 1 and PS00608 Glycosyl hydrolases family 2 acid /base catalyst. Also contains Pfam match to entry PF00703 glycosyl_hydro7%2C Glycosyl hydrolases family 2. gene gene6517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6457 SCO6458 SCO6458 SC9B5.25 SC9B5.25 7146169 7147047 + hypothetical protein SC9B5.25%2C unknown%2C len: 292aa%3B similar to TR:O32135 (EMBL:Z99120) hypothetical protein from Bacillus subtilis (284 aa) fasta scores: opt: 304%2C z-score: 523.6%2C E(): 7.2e-22%2C (32.1%25 identity in 293 aa overlap). gene gene6518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6458 SCO6459 SCO6459 SC9B5.26c SC9B5.26c 7147028 7147390 - regulatory protein SC9B5.26c%2C probable regulatory protein%2C len: 120aa%3B similar to many eg. TR:O69711 (EMBL:AL022121) regulatory protein from Mycobacterium tuberculosis (120 aa) fasta scores: opt: 480%2C z-score: 880.6%2C E(): 0%2C (63.2%25 identity in 117 aa overlap) and TR:O54057 (EMBL:AJ001934) nolR%2C negative regulator of nodulation genes in Rhizobium leguminosarum bv. viciae strain TOM (105 aa) fasta scores: opt: 156%2C z-score: 262.6%2C E(): 2.4e-07%2C (34.4%25 identity in 93 aa overlap). Contains Pfam match to entry PF01022 HTH_ARSR_family%2C Bacterial regulatory protein%2C arsR family corresponding to a probable helix-turn-helix at residues 51 to 72 (+5.18 SD). gene gene6519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6459 SCO6460 SCO6460 SC9B5.27 SC9B5.27 7147460 7149376 + cation-transporting ATPase SC9B5.27%2C possible cation-transporting ATPase%2C len: 638aa%3B similar to many cation-transporting ATPases eg. SW:COPA_ENTHR copper /potassium-transporting%3D from Enterococcus hirae (727 aa) fasta scores: opt: 980%2C z-score: 936.0%2C E(): 0%2C (31.9%25 identity in 630 aa overlap). Contains PS00154 E1-E2 ATPases phosphorylation site and Pfam match to entry PF00122 E1-E2_ATPase%2C E1-E2 ATPases. gene gene6520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6460 SCO6461 SCO6461 SC9B5.28 SC9B5.28 7149468 7150940 + ADA-like regulatory protein SC9B5.28%2C possible ADA-like regulatory protein%2C len: 490 aa%3B similar to SC1A9.14 (EMBL:AL034446) possible ADA-like regulatory protein from Streptomyces coelicolor (477 aa) fasta scores: opt: 1192%2C z-score: 937.1%2C E(): 0%2C (53.3%25 identity in 501 aa overlap). Also similar to ADA_MYCTU ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores%3B opt: 2185%2C z-score: 2395.4%2C E(): 0%2C (66.7%25 identity in 490 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI ADA regulatory protein from Escherichia coli (354 aa) fasta scores%3B opt: 257%2C z-score: 248.0%2C E(): 1.6e-06%2C (31.3%25 identity in 182 aa overlap) and C-terminal region similar to 3MG2_ECOLI AlkA%2C 3-methyladenine DNA glycosylase II involved in DNA repair (282 aa) fasta scores%3B opt: 450%2C z-score: 413.0%2C E(): 1e-15%2C (32.5%25 identity in 286 aa overlap). Contains PS00041 araC family signature%2C Pfam matches PF00165 HTH_2 helix-turn-helix /araC and PF01332 AlkA_DNA_repair%2C Alkylbase DNA glycosidases alkA family. gene gene6521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6461 SCO6462 SCO6462 SC9B5.29 SC9B5.29 7151007 7151501 + methylated-DNA-protein-cysteine methyltransferase SC9B5.29%2C ogt2%2C methylated-DNA-protein-cysteine methyltransferase len: 186 aa%3B similar to many eg. SW:DAT1_BACSU methylated-DNA-protein-cysteine methyltransferase from Bacillus subtilis (165 aa) fasta scores%3B opt: 437%2C z-score: 636.5%2C E(): 3.7e-28%2C (46.2%25 identity in 156 aa overlap) and SC1A9.15 (EMBL:AL034446) ogt%2C methylated-DNA-protein-cysteine methyltransferase from Streptomyces coelicolor (186 aa) fasta scores: opt: 466%2C z-score: 648.6%2C E(): 2.6e-31%2C (52.7%25 identity in 150 aa overlap). Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site and Pfam match to entry PF01035 Methyltrans%2C 6-O-methylguanine DNA methyltransferase. gene gene6522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6462 SCO6463 SCO6463 SC9B5.30 SC9B5.30 7151706 7152575 + hypothetical protein SC9B5.30%2C hypothetical protein%2C len: 289aa%3B similar to many eg. TR:O06216 (EMBL:Z95388) from Mycobacterium tuberculosis (288 aa) fasta scores: opt: 272%2C z-score: 302.0%2C E(): 1.6e-09%2C (30.1%25 identity in 259 aa overlap). gene gene6523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6463 SCO6464 SCO6464 SC1A11.01c SC1A11.01c 7152607 7153332 - SIR2 family transcriptional regulator SC1A11.01c%3B partial CDS%2C possible SIR2 family transcriptional regulator%2C len: 86 aa%3B overlapping N-terminal region of SC9B5.31c%2C from Streptomyces coelicolor cosmid 9B5. Similar to hypothetical proteins and proposed SIR2 family transcriptional regulators eg. TR:O28597 (EMBL:AE000987) proposed transcriptional regulatory protein%2C SIR2 family from Archaeoglobus fulgidus (245 aa) fasta scores%3B opt: 221%2C z-score: 297.7%2C E(): 2.7e-09%2C (36.2%25 identity in 185 aa overlap).~SC9B5.31c%3B partial CDS%2C possible SIR2 family transcriptional regulator%2C len: 190aa%3B overlapping C-terminal region of SC1A11.01c%2C from Streptomyces coelicolor cosmid 1A11. Similar to hypothetical proteins and proposed SIR2 family transcriptional regulators eg. TR:O28597 (EMBL:AE000987) proposed transcriptional regulatory protein%2C SIR2 family from Archaeoglobus fulgidus (245 aa) fasta scores%3B opt: 370%2C z-score: 428.3%2C E(): 1.4e-16%2C (36.2%25 identity in 185 aa overlap). gene gene6524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6464 SCO6465 SCO6465 SC1A11.02c SC1A11.02c 7153374 7153868 - hypothetical protein SC1A11.02c%2C partial CDS%2C unknown%2C len: 134aa%3B N-terminal region similar to TR:O27370 (EMBL:AE000895) proposed mutator MutT protein from Methanobacterium thermoautotrophicum (135 aa) fasta scores%3B opt: 148%2C z-score: 219.8%2C E(): 5.9e-05%2C (43.5%25 identity in 62 aa overlap).~SC9C7.01c%2C partial CDS%2C unknown%2C len: 49aa%3B overlapping extreme N-terminal region of partial CDS%2C SC1A11.2c from Streptomyces coelicolor cosmid 1A11. gene gene6525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6465 SCO6466 SCO6466 SC9C7.02 SC9C7.02 7154053 7155195 + transferase SC9C7.02%2C conserved hypothetical protein%2C len: 380 aa%3B similar to many e.g. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores%3B opt: 1045%2C z-score: 998.9%2C E(): 0%2C (46.3%25 identity in 374 aa overlap) and to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK%2C 382 aa%3B fasta scores: opt: 1045 Z-score: 991.1 E(): 1.4e-47%3B 46.257%25 identity in 374 aa overlap gene gene6526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6466 SCO6467 SCO6467 SC9C7.03c SC9C7.03c 7155465 7156247 - phosphatidylserine synthase SC9C7.03c%2C probable integral membrane protein%2C possible phosphatidylserine synthase%2C len: 260 aa%3B similar to many from prokaryotes (all ) and eukaryotes eg. SW:PSS_YEAST phosphatidylserine synthase from Saccharomyces cerevisiae (275 aa) fasta scores%3B opt: 187%2C z-score: 254.6%2C E(): 6.8e-07%2C (35.9%25 identity in 170 aa overlap). Contains possible membrane spanning regions gene gene6527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6467 SCO6468 SCO6468 SC9C7.04c SC9C7.04c 7156306 7156962 - phosphatidylserine decarboxylase catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine gene gene6528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6468 SCO6469 SCO6469 SC9C7.05c SC9C7.05c 7157133 7158338 - acyl-CoA dehydrogenase SC9C7.05c%2C possible acyl-CoA dehydrogenase%2C len: 401aa%3B similar to many from prokaryotes and eukaryotes egs. SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores%3B opt: 520%2C z-score: 1209.6%2C E(): 0%2C (38.9%25 identity in 386 aa overlap) and SW:ACDM_MOUSE acyl-CoA dehydrogenase from Mus musculus (mouse) (421 aa) fasta scores%3B opt: 484%2C z-score: 1178.1%2C E(): 0%2C (40.3%25 identity in 390 aa overlap). Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase. gene gene6529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6469 SCO6470 SCO6470 SC9C7.06c SC9C7.06c 7158341 7158853 - hypothetical protein SC9C7.06c%2C unknown%2C len: 170 aa%3B similar to TR:O06163 (EMBL:Z95556) from Mycobacterium tuberculosis (185 aa) fasta scores%3B opt: 342%2C z-score: 497.2%2C E(): 2.1e-20%2C (38.8%25 identity in 152 aa overlap). gene gene6530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6470 SCO6471 SCO6471 SC9C7.07c SC9C7.07c 7158859 7159878 - citratelyase SC9C7.07c%2C probable citratelyase%2C len: 339 aa%3B similar to many e.g. SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores%3B opt: 187%2C z-score: 643.3%2C E(): 1.5e-28%2C (30.5%25 identity in 298 aa overlap). gene gene6531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6471 SCO6472 SCO6472 SC9C7.08c SC9C7.08c 7159875 7161902 - coenzyme B12-dependent mutase SC9C7.08c%2C meaA%2C coenzyme B12-dependent mutase%2C len: 675aa%3B similar to many%2C very similar to TR:O33614 (EMBL:AF008569) coenzyme B12-dependent mutase from Streptomyces collinus (674 aa) fasta scores%3B opt: 4085%2C z-score: 5046.6%2C E(): 0%2C (91.7%25 identity in 675 aa overlap). gene gene6532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6472 SCO6473 SCO6473 SC9C7.09c SC9C7.09c 7161921 7163264 - crotonyl CoA reductase SC9C7.09c%2C ccr%2C crotonyl CoA reductase%2C len: 447aa%3B similar to many%2C very similar to EMBL:U37135 ccr%2C crotonyl CoA reductase from Streptomyces collinus (447 aa) fasta scores%3B opt: 2819%2C z-score: 3635.0%2C E(): 0%2C (92.6%25 identity in 447 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene6533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6473 SCO6474 SCO6474 SC9C7.10c SC9C7.10c 7163600 7164418 - transcriptional regulator SC9C7.10c%2C possible transcriptional regulator%2C len: 272 aa%3B similar to many hypotheticals and SW:TCMR_STRGA TcmR%2C tetracenomycin C transcriptional repressor from Streptomyces glaucescens (226 aa) fasta scores%3B opt: 221%2C z-score: 260.3%2C E(): 3.3e-07%2C (31.7%25 identity in 221 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains a probable helix-turn-helix from residue 53 to 74 (+3.47 SD). gene gene6534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6474 SCO6475 SCO6475 SC9C7.11c SC9C7.11c 7164555 7166360 - oxidoreductase SC9C7.11c%2C probable oxidoreductase%2C len: 601aa%3B similar to many eg. TR:Q45815 (EMBL:M31799) NAD-dependent beta-hydroxybutyryl coenzyme dehydrogenase from Clostridium acetobutylicum (282 aa) fasta scores%3B opt: 801%2C z-score: 936.4%2C E(): 0%2C (41.1%25 identity in 280 aa overlap). Appears to be a fusion of two dehydrogesase as each half contains Pfam match to entry PF00725 3HCDH%2C 3-hydroxyacyl-CoA dehydrogenase. gene gene6535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6475 SCO6476 SCO6476 SC9C7.12 SC9C7.12 7166743 7167336 + adenylosuccinate lyase Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide gene gene6536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6476 SCO6477 SCO6477 SC9C7.13c SC9C7.13c 7167374 7167913 - hypothetical protein SC9C7.13c%2C unknown%2C len: 179 aa%3B similar to TR:O32075 (EMBL:Z99119) hypothetical protein from Bacillus subtilis (173 aa) fasta scores%3B opt: 261%2C z-score: 298.5%2C E(): 2.4e-09%2C (32.9%25 identity in 170 aa overlap). Contains a region of weak similarity to Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene6537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6477 SCO6478 SCO6478 SC9C7.14c SC9C7.14c 7167910 7168308 - hypothetical protein SC9C7.14c%2C conserved hypothetical protein%2C len: 132aa%3B similar to many hypotheticals eg. TR:P75896 (EMBL:AE000202) from Escherichia coli (128 aa) fasta scores%3B opt: 249%2C z-score: 350.3%2C E(): 3.2e-12%2C (39.2%25 identity in 125 aa overlap). Contains Pfam match to entry PF01042 DUF10%2C Domain of unknown function. gene gene6538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6478 SCO6479 SCO6479 SC9C7.15c SC9C7.15c 7168375 7169964 - peptidase SC9C7.15c%2C probable peptidase%2C len: 529aa%3B similar to many eg. TR:Q54410(EMBL:L27466) tripeptidyl aminopeptidase from Streptomyces lividans 66 (537 aa) fasta scores%3B opt: 1362%2C z-score: 1170.0%2C E(): 0%2C (43.2%25 identity in 526 aa overlap)%2C has probable N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase%2C alpha /beta hydrolase fold. Also similar to TR:O69831 (EMBL:AL023517) from Streptomyces coelicolor cosmid 1B5 (543 aa) fasta scores%3B opt: 1205%2C z-score: 1105.7%2C E(): 0%2C (42.3%25 identity in 541 aa overlap). gene gene6539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6479 SCO6480 SCO6480 SC9C7.16c SC9C7.16c 7170144 7170443 - hypothetical protein SC9C7.16c%2C unknown%2C len: 99 aa gene gene6540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6480 SCO6481 SCO6481 SC9C7.17c SC9C7.17c 7170517 7171563 - hypothetical protein SC9C7.17c%2C conserved hypothetical protein%2C len: 348aa%3B similar to several hypothetical proteins eg. SW:Y0BN_MYCTU from Mycobacterium tuberculosis (340 aa) fasta scores%3B opt: 998%2C z-score: 1321.8%2C E(): 0%2C (47.6%25 identity in 355 aa overlap). gene gene6541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6481 SCO6482 SCO6482 SC9C7.18 SC9C7.18 7171800 7172243 + hypothetical protein SC9C7.18%2C conserved hypothetical protein%2C len: 348 aa%3B similar to two hypothetical proteins e.g. TR:O69685 (EMBL:AL022121) Mycobacterium tuberculosis RV03718c or MTV025.066c%2C 147 aa%3B fasta scores%3B opt: 475%2C z-score: 768.3%2C E(): 0%2C (52.1%25 identity in 146 aa overlap) gene gene6542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6482 SCO6483 SCO6483 SC9C7.19 SC9C7.19 7172394 7174841 + efflux protein SC9C7.19%2C probable efflux protein%2C len: 815aa%3B similar to many%2C several of which are involved in toxin /antibiotic efflux eg. TR:O69070 (EMBL:AF061335) oxytetracycline exporter from Streptomyces rimosus (536 aa) fasta scores%3B opt: 1020%2C z-score: 879.9%2C E(): 0%2C (36.9%25 identity in 542 aa overlap). gene gene6543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6483 SCO6484 SCO6484 SC9C7.20 SC9C7.20 7174911 7177493 + hypothetical protein SC9C7.20%2C conserved hypothetical protein%2C len: 860aa%3B similar to many hypothetical proteins egs. TR:O86875 (EMBL:U22894) from Streptomyces lividans (547 aa) fasta scores%3B opt: 1000%2C z-score: 738.2%2C E(): 0%2C (40.0%25 identity in 497 aa overlap) and TR:O86807 (EMBL:AL031031) from Streptomyces coelicolor (916 aa) fasta scores%3B opt: 358%2C z-score: 316.9%2C E(): 2.3e-10%2C (27.2%25 identity in 779 aa overlap). Also contains a short region of similarity to TR:Q53897 (EMBL:X60316) AbaA regulatory locus from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 108%2C z-score: 223.2%2C E(): 3.8e-05%2C (38.5%25 identity in 135 aa overlap). gene gene6544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6484 SCO6485 SCO6485 SC9C7.21 SC9C7.21 7177711 7178433 + hypothetical protein SC9C7.21%2C unknown%2C len: 240 aa gene gene6545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6485 SCO6486 SCO6486 SC9C7.22 SC9C7.22 7178603 7179436 + transport associated protein SC9C7.22%2C possible transport associated protein%2C len: 277aa%3B similar to SW:DPPA_BACSU dppA%2C dipeptide transport protein (274 aa) fasta scores%3B opt: 448%2C z-score: 604.3%2C E(): 2.3e-26%2C (32.3%25 identity in 269 aa overlap). gene gene6546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6486 SCO6487 SCO6487 SC9C7.23 SC9C7.23 7179429 7180760 + hypothetical protein SC9C7.23%2C possible aminoacylase%2C len: 443aa%3B similar to many aminoacylases and hypothetical proteins egs. TR:O06234 (EMBL:Z95388) hypothetical protein from Mycobacterium tuberculosis (448 aa) fasta scores%3B opt: 1278%2C z-score: 1467.2%2C E(): 0%2C (47.2%25 identity in 449 aa overlap) and SW:ACY1_PIG aminoacylase I from Sus scrofa (pig) (406 aa) fasta scores%3B opt: 294%2C z-score: 340.6%2C E(): 1.1e-11%2C (27.3%25 identity in 421 aa overlap). Contains PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. gene gene6547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6487 SCO6488 SCO6488 SC9C7.24 SC9C7.24 7180803 7182770 + acyl-peptide hydrolase SC9C7.24%2C possible acyl-peptide hydrolase%2C len: 651aa%3B similar to many acyl-peptide hydrolases and hypothetical proteins egs. TR:Q55413 (EMBL:D64003) hypothetical protein from Synechocystis sp. (strain PCC 6803) (637 aa) fasta scores%3B opt: 1306%2C z-score: 1326.5%2C E(): 0%2C (39.6%25 identity in 647 aa overlap) and TR:P70479 (EMBL:X14915) acyl-peptide hydrolase from Rattus norvegicus (rat) (729 aa) fasta scores%3B opt: 258%2C z-score: 199.2%2C E(): 0.00083%2C (28.2%25 identity in 234 aa overlap). gene gene6548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6488 SCO6489 SCO6489 SC9C7.25 SC9C7.25 7182776 7183708 + hypothetical protein SC9C7.25%2C conserved hypothetical protein%2C len: 310 aa%3B similar to several proteins of undefined function egs. TR:P74220 (EMBL:D90913) hypothetical protein from Synechocystis sp. (strain PCC 6803) (301 aa) fasta scores%3B opt: 642%2C z-score: 649.7%2C E(): 6.7e-29%2C (38.8%25 identity in 309 aa overlap) and TR:Q47511 (EMBL:X57583) MccF protein from Escherichia coli plasmid pMCCC7 thought to be involved in self-immunity to translation inhibitor microcin C7 (344 aa) fasta scores%3B opt: 178%2C z-score: 259.5%2C E(): 3.6e-07%2C (25.1%25 identity in 339 aa overlap) gene gene6549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6489 SCO6490 SCO6490 SC9C7.26 SC9C7.26 7183718 7184317 + acetyltransferase SC9C7.26%2C possible acetyltransferase%2C len: 199 aa%3B similar to SW:RIMJ_ECOLI ribosomal-protein-alanine acetyltransferase from Escherichia coli (194 aa) fasta scores%3B opt: 248%2C z-score: 351.1%2C E(): 2.9e-12%2C (38.7%25 identity in 111 aa overlap). gene gene6550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6490 SCO6491 SCO6491 SC9C7.27c SC9C7.27c 7184289 7184681 - hypothetical protein SC9C7.27c%2C unknown%2C len: 130aa gene gene6551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6491 SCO6492 SCO6492 SC1E6.01 SC1E6.01 7184832 7186829 + hypothetical protein SC1E6.01%2C unknown%2C partial CDS%2C len: >616 aa%2C some similarity to hypothetical protein YPHG_ECOLI (1124 aa)%2C fasta scores%3B opt: 360 z-score: 279.9 E(): 2.6e-08%2C 27.1%25 identity in 310 aa overlap~SC9C7.28%2C partial CDS%2C unknown%2C len: 83 aa%3B constitutes the N-terminus of TR:E1341375 (EMBL:AL033505) hypothetical protein from Streptomyces coelicolor. gene gene6552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6492 SCO6493 SCO6493 SC1E6.02c SC1E6.02c 7186861 7187208 - hypothetical protein SC1E6.02c%2C unknown%2C len: 115 aa gene gene6553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6493 SCO6494 SCO6494 SC1E6.03 SC1E6.03 7187223 7187840 + hypothetical protein SC1E6.03%2C membrane protein%2C len: 205 aa%3B contains two possible transmembrane domains in centre gene gene6554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6494 SCO6495 SCO6495 SC1E6.04c SC1E6.04c 7187926 7188888 - dehydrogenase SC1E6.04c%2C probable dehydrogenase%2C len: 320 aa%3B similar to Mycobacterial F420-dependent glucose-6-phosphate dehydrogenases e.g. M. smegmatis TR:O68447 (EMBL:AF041061) F420-dependent glucose-6-phosphate dehydrogenase (336 aa)%2C fasta scores%3B opt: 499 z-score: 362.9 E(): 6.2e-13%2C 33.2%25 identity in 331 aa overlap gene gene6555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6495 SCO6496 SCO6496 SC1E6.05 SC1E6.05 7189075 7190964 + dehydrogenase SC1E6.05%2C probable dehydrogenase%2C len: 629 aa%3B similar to e.g. Mycobacterium smegmatis TR:O52473 (EMBL:AF038423) NADH dehydrogenase (457 aa)%2C fasta scores%3B opt: 499 z-score: 263.3 E(): 2.2e-07%2C 31.2%25 identity in 417 aa overlap. Contains 6x degenerate repeats of the sequence KNQPGGEP(A /G)%3D (P-loop) gene gene6556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6496 SCO6497 SCO6497 tktA2 tktA2 7190961 7192808 + transketolase catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate%3B can transfer ketol groups between several groups%3B in Escherichia coli there are two tkt genes%2C tktA expressed during exponential growth and the tktB during stationary phase gene gene6557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6497 SCO6498 SCO6498 SC1E6.07 SC1E6.07 7192805 7193764 + hypothetical protein SC1E6.07%2C unknown%2C len: 319 aa%3B similar to hypothetical protein from Mycobacteria e.g. TR:O69697 (EMBL:AL022121) MTV025.078C (346 aa)%2C fasta scores%3B opt: 537 z-score: 578.0 E(): 6.5e-25%2C 34.9%25 identity in 292 aa overlap gene gene6558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6498 SCO6499 SCO6499 gvpO gvpO 7193830 7194222 + gas vesicle synthesis protein SC1E6.08%2C gvpO%2C probable gas vesicle synthesis protein%2C len: 130 aa%3B similar to several from Halobacteria e.g. GVO1_HALSA GVPO protein%2C plasmid (120 aa)%2C fasta scores%3B opt: 167 z-score: 285.9 E(): 1.2e-08%2C 30.2%25 identity in 106 aa overlap. Contains 9x degenerate QXS repeat near N-terminus and apparent helix-turn-helix motif at aa 53-74 (Score 1244%2C +3.42 SD) gene gene6559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6499 SCO6500 SCO6500 gvpA gvpA 7194294 7194728 + gas vesicle synthesis-like protein similar to the gas vesicle synthesis protein GvpA in other bacteria but contains an extended C-terminal tail%3B function in the Streptomyces group is unknown but they contain several homologs of other gas vesicle synthesis proteins gene gene6560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6500 SCO6501 SCO6501 gvpF gvpF 7194725 7195498 + gas vesicle synthesis protein SC1E6.10%2C gvpF%2C probable gas vesicle synthesis protein%2C len: 257 aa%3B some similarity to GVF2_HALSA GVPF protein%2C chromosomal (217 aa)%2C fasta scores%3B opt: 143 z-score: 191.0 E(): 0.0023%2C 27.1%25 identity in 247 aa overlap gene gene6561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6501 SCO6502 SCO6502 gvpG gvpG 7195503 7195766 + gas vesicle synthesis protein SC1E6.11%2C gvpG%2C probable gas vesicle synthesis protein%2C len: 87 aa%3B simlar to e.g. TR:O68673 (EMBL:AF053765) gas vesicle protein GVPG (88 aa)%2C fasta scores%3B opt: 152 z-score: 269.8 E(): 9.5e-08%2C 49.1%25 identity in 53 aa overlap. Contains probable coiled-coil from aa 37 to 76 gene gene6562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6502 SCO6503 SCO6503 SC1E6.12 SC1E6.12 7195763 7196482 + hypothetical protein SC1E6.12%2C unknown%2C len: 239 aa%3B contains highly acidic repetitive stretch between aa 120-180 and highly basic repetitive stretch between aa 180-239 gene gene6563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6503 SCO6504 SCO6504 SC1E6.13 SC1E6.13 7196479 7197609 + hypothetical protein SC1E6.13%2C unknown%2C len: 376 aa%3B some similarity in part to YMEL_STRLN Streptomyces lincolnensis hypothetical protein (150 aa)%2C fasta scores%3B opt: 377 z-score: 448.8 E(): 1e-17%2C 36.1%25 identity in 144 aa overlap. Contains highly acidic repetitive region from aa 290-376 gene gene6564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6504 SCO6505 SCO6505 gvpJ gvpJ 7197606 7197935 + gas vesicle synthesis protein SC1E6.14%2C gvpJ%2C probable gas vesicle synthesis protein%2C len: 109 aa%3B similar to e.g. TR:O68669 (EMBL:AF053765) gas vesicle protein GVPJ from Bacillus megaterium (100 aa)%2C fasta scores%3B opt: 358 z-score: 597.2 E(): 5.5e-26%2C 61.6%25 identity in 86 aa overlap. Contains PS00234 Gas vesicles protein GVPa signature 1 and Pfam match to entry PF00741 Gas_vesicle%2C Gas vesicle protein%2C score 60.90%2C E-value 2.8e-14 gene gene6565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6505 SCO6506 SCO6506 gvpL gvpL 7197932 7198711 + gas vesicle protein SC1E6.15%2C gvpL%2C probable gas vesicle protein%2C len: 504 aa%3B simialar to e.g. GVL1_HALSA GVPL protein%2C plasmid (281 aa)%2C fasta scores%3B opt: 111 z-score: 229.0 E(): 1.8e-05%2C 24.2%25 identity in 264 aa overlap gene gene6566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6506 SCO6507 SCO6507 gvpS gvpS 7198708 7198890 + gas vesicle synthesis protein SC1E6.16%2C gvpS%2C probable gas vesicle synthesis protein%2C len: 60 aa%3B similar to parts of several gas vesicle proteins e.g. Bacillus megaterium TR:O68671 (EMBL:AF053765) gas vesicle protein GVPS (95 aa)%2C fasta scores%3B opt: 163 z-score: 303.6 E(): 1.2e-09%2C 49.1%25 identity in 57 aa overlap%2C and TR:O68669 (EMBL:AF053765) gas vesicle protein GVPJ (100 aa)%2C fasta scores%3B opt: 130 z-score: 256.8 E(): 5.1e-07%2C 45.2%25 identity in 42 aa overlap. Contains Pfam match to entry PF00741 Gas_vesicle%2C Gas vesicle protein%2C score 31.70%2C E-value 1.7e-05 gene gene6567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6507 SCO6508 SCO6508 gvpK gvpK 7198892 7199188 + gas vesicle synthesis protein SC1E6.17%2C gvpK%2C probable gas vesicle synthesis protein%2C len: 98 aa%3B simlar to e.g. Bacillus megaterium TR:O68670 gas vesicle protein GVPK (94 aa)%2C fasta scores%3B opt: 321 z-score: 536.7 E(): 1.3e-22%2C 50.5%25 identity in 93 aa overlap gene gene6568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6508 SCO6509 SCO6509 SC1E6.18c SC1E6.18c 7199279 7199449 - hydrophobic protein SC1E6.18c%2C small hydrophobic protein%2C len: 56 aa. Contains possible hydrophobic membrane spanning regions gene gene6569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6509 SCO6510 SCO6510 SC1E6.19c SC1E6.19c 7199504 7200325 - hypothetical protein SC1E6.19c%2C unknown%2C len: 273 aa%3B similar to hypothetical proteins e.g. M. tuberculosis TR:O53851 (EMBL:AL022004) MTV043.32 (270 aa)%2C fasta scores%3B opt: 1102 z-score: 1628.2 E(): 0%2C 58.6%25 identity in 263 aa overlap%2C and in part%2C to several methyltransferases e.g. PMTA_RHOSH phosphatidylethanolamine N-methyltransferase (203 aa)%2C fasta scores%3B opt: 198 z-score: 248.3 E(): 1.5e-06%2C 37.3%25 identity in 102 aa overlap gene gene6570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6510 SCO6511 SCO6511 SC1E6.20c SC1E6.20c 7200436 7201941 - hypothetical protein SC1E6.20c%2C unknown%2C len: 501 aa%3B similar to two hypothetical proteins from Rhodococcus erythropolis: TR:P72262 (EMBL:Z82004) ORF8 (487 aa)%2C fasta scores%3B opt: 1098 z-score: 762.9 E(): 0%2C 45.5%25 identity in 488 aa overlap%2C and TR:P72269 (EMBL:Z82005) ORF8 (487 aa)%2C fasta scores%3B opt: 1060 z-score: 717.1 E(): 1.2e-32%2C 41.7%25 identity in 487 aa overlap. Contains Pfam match to entry PF00781 DAGKc%2C Diacylglycerol kinase catalytic domain (presumed)%2C score 31.00%2C E-value 1.3e-05 gene gene6571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6511 SCO6512 SCO6512 SC1E6.21 SC1E6.21 7202065 7203684 + ABC transporter ATP-binding protein SC1E6.21%2C probable ABC transporter ATP-binding protein%2C len: 539 aa%3B similar to many e.g. TLRC_STRFR tylosin resistance ATP-binding protein TLRC (548 aa)%2C fasta scores%3B opt: 449 z-score: 533.0 E(): 2.1e-22%2C 33.0%25 identity in 542 aa overlap. Contains 2x PS00017 ATP /GTP-binding site motif A (P-loop) and 2x Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C scores 125.80%2C E-value 8.1e-34%2C and 69.10%2C E-value 9.1e-17 gene gene6572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6512 SCO6513 SCO6513 SC1E6.22c SC1E6.22c 7203714 7204835 - hypothetical protein SC1E6.22c%2C unknown%2C len: 373 aa%3B similar to a hypothetical protein from M. tuberculosis TR:O06183 (EMBL:Z95387) MTCY1A10.03C (374 aa)%2C fasta scores%3B opt: 425 z-score: 395.8 E(): 9.2e-15%2C 30.2%25 identity in 371 aa overlap gene gene6573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6513 SCO6514 SCO6514 SC1E6.23 SC1E6.23 7204898 7205176 + hypothetical protein SC1E6.23%2C unknown%2C len: 92 aa gene gene6574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6514 SCO6515 SCO6515 pfpI pfpI 7205258 7205800 - protease SC1E6.24c%2C pfpI%2C probable protease%2C len: 180 aa%3B similar to e.g. PFPI_PYRFU protease I (EC 3.2.-.-) (166 aa)%2C fasta scores%3B opt: 413 z-score: 411.9 E(): 1.2e-15%2C 41.3%25 identity in 172 aa overlap gene gene6575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6515 SCO6516 SCO6516 SC1E6.25c SC1E6.25c 7205826 7206224 - hypothetical protein SC5C7.01c%2C unknown%2C partial CDS%2C len: >45 aa~SC1E6.25c%2C unknown%2C partial CDS%2C len: > 123 aa%3B continuation of SC5C7.01c gene gene6576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6516 SCO6517 SCO6517 SC5C7.02 SC5C7.02 7206433 7208823 + uvrA-like protein SC5C7.02%2C uvrA-like protein%2C len: 796 aa%3B similar to Streptomyces peucetius TR:Q54827 (EMBL:L76359) daunorubicin resistance protein drrC (764 aa)%2C fasta scores%3B opt: 2051 z-score: 2702.2 E(): 0%2C 51.1%25 identity in 775 aa overlap%2C and to many uvrA proteins e.g. UVRA_NEIGO excinuclease ABC subunit A (950 aa)%2C fasta scores%3B opt: 412 z-score: 1697.0 E(): 0%2C 34.1%25 identity in 953 aa overlap. Contains 2x PS00017 ATP /GTP-binding%3D match to entry PF00005 ABC_tran%2C ABC transporters%2C scores 42.40%2C E-value 1.7e-10 and 71.20%2C E-value 2.2e-17 gene gene6577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6517 SCO6518 SCO6518 SC5C7.03 SC5C7.03 7208891 7209373 + transcriptional regulator SC5C7.03%2C probable transcriptional regulator%2C len: 160 aa%3B similar in N-terminus to many e.g. RAMA_ENTCL transcriptional activator RamA (113 aa)%2C fasta scores%3B opt: 175 z-score: 255.3 E(): 5.7e-07%2C 32.3%25 identity in 96 aa overlap. C-terminal 50 aa are unique. Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C score 71.40%2C E-value 1.9e-17 gene gene6578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6518 SCO6519 SCO6519 SC5C7.04 SC5C7.04 7209379 7209795 + lyase SC5C7.04%2C possible lyase%2C similar to e.g. LGUL_HAEIN lactoylglutathione lyase (EC 4.4.1.5) (135 aa)%2C fasta scores%3B opt: 124 z-score: 215.2 E(): 9.7e-05%2C 29.0%25 identity in 131 aa overlap gene gene6579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6519 SCO6520 SCO6520 SC5C7.05 SC5C7.05 7210082 7210882 + RNA polymerase sigma factor SC5C7.05%2C probable RNA polymerase sigma factor%2C len: 266 aa%3B simlar to S. coelicolor sigma factors of the SigB subfamily e.g. TR:O52313 (EMBL:AF036131) RNA polymerase secondary sigma factor SigG (263 aa)%2C fasta scores%3B opt: 1258 z-score: 1540.5 E(): 0%2C 72.9%25 identity in 251 aa overlap%2C and to RPOF_STRAU RNA polymerase sigma-F factor (297 aa)%2C fasta scores%3B opt: 713 z-score: 858.3 E(): 0%2C 42.6%25 identity in 312 aa overlap. Possible alternative start 216 bp upstream%2C not supported by FramePlot. Contains helix-turn-helix motif at aa 228-249 (Score 2104%2C +6.35 SD) and Pfam match to entry PF00140 sigma70%2C Sigma-70 factors%2C score 210.40%2C E-value 2.8e-59 gene gene6580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6520 SCO6521 SCO6521 SC5C7.06 SC5C7.06 7211022 7211978 + hypothetical protein SC5C7.06%2C probable hypothetical protein%2C len: 318 aa%3B contains N-terminal signal sequence gene gene6581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6521 SCO6522 SCO6522 SC5C7.07 SC5C7.07 7212047 7213489 + hypothetical protein SC5C7.07%2C unknown%2C len: 480 aa gene gene6582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6522 SCO6523 SCO6523 SC5C7.08 SC5C7.08 7213486 7214526 + hypothetical protein SC5C7.08%2C unknown%2C len: 346 aa%3B similar to hypothetical proteins from M. tuberculosis YZ34_MYCTU MTCY31.34 (372 aa)%2C fasta scores%3B opt: 678 z-score: 492.0 E(): 3.7e-20%2C 42.3%25 identity in 298 aa overlap%2C and to Saccharomyces cerevisiae TR:Q02883 (EMBL:U43281) LPG6P (468 aa)%2C fasta scores%3B opt: 491 z-score: 495.9 E(): 2.2e-20%2C 35.5%25 identity in 262 aa overlap gene gene6583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6523 SCO6524 SCO6524 SC5C7.09c SC5C7.09c 7214569 7215195 - hypothetical protein SC5C7.09c%2C probable integral membrane protein%2C len: 208 aa. Contains possible hydrophobic membrane spanning regions gene gene6584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6524 SCO6525 SCO6525 SC5C7.10c SC5C7.10c 7215192 7215959 - hypothetical protein SC5C7.10c%2C unknown%2C len: 255 aa%3B similar to hypothetical proteins from many organisms e.g. M. tuberculosis YZ34_MYCTU MTCY31.34 (372 aa)%2C fasta scores%3B opt: 221 z-score: 293.2 E(): 4.4e-09%2C 30.7%25 identity in 251 aa overlap gene gene6585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6525 SCO6526 SCO6526 SC5C7.11 SC5C7.11 7216060 7216461 + hypothetical protein SC5C7.11%2C unknown%2C len: 133 aa gene gene6586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6526 SCO6527 SCO6527 SC5C7.12 SC5C7.12 7216569 7218722 + hypothetical protein SC5C7.12%2C probable membrane protein%2C len: 717 aa%3B contains large hydrophobic domain at N-terminus gene gene6587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6527 SCO6528 SCO6528 SC5C7.13 SC5C7.13 7218804 7220228 + integral membrane transport protein SC5C7.13%2C probable integral membrane transport protein%2C len: 474 aa%3B similar to many e.g. ARCD_PSEAE arginine/ornithine antiporter (482 aa)%2C fasta scores%3B opt: 560 z-score: 470.6 E(): 5.8e-19%2C 28.9%25 identity in 439 aa overlap gene gene6588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6528 SCO6529 SCO6529 SC5C7.14 SC5C7.14 7220309 7221370 + ATP/GTP binding protein SC5C7.14%2C probable ATP/GTP binding protein%2C len: 353 aa%3B similar to TR:Q9RV59 (EMBL:AE001966) Deinococcus radiodurans conserved hypothetical protein DR1171%2C 340 aa%3B fasta scores: opt: 453 Z-score: 502.2 E(): 2.4e-20%3B 33.692%25 identity in 279 aa overlap. Contains Prosite match to entry PS00017 ATP/GTP-binding gene gene6589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6529 SCO6530 SCO6530 SC5C7.15 SC5C7.15 7221367 7223199 + hypothetical protein SC5C7.15%2C unknown%2C len: 610 aa%3B contains Gln- and Lys-rich N-terminus gene gene6590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6530 SCO6531 SCO6531 SC5C7.16 SC5C7.16 7223286 7223711 + ATP/GTP binding protein SC5C7.16%2C probable ATP/GTP binding protein%2C len: 141 aa%3B highly similar to OSMC_ECOLI osmotically inducible protein C (143 aa)%2C fasta scores%3B opt: 330 z-score: 398.2 E(): 6.2e-15%2C 44.5%25 identity in 137 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene6591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6531 SCO6532 SCO6532 narI narI 7223740 7224462 - nitrate reductase subunit gamma NarI SC5C7.17c%2C narI%2C probable nitrate reductase gamma chain%3B len: 240 aa%3B similar to many e.g. NARI_BACSU nitrate reductase gamma chain (EC 1.7.99.4) (223 aa)%2C fasta scores%3B opt: 664 z-score: 1084.3 E(): 0%2C 41.5%25 identity in 217 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6532 SCO6533 SCO6533 narJ narJ 7224459 7224953 - nitrate reductase subunit delta NarJ SC5C7.18c%2C narJ%2C probable nitrate reductase delta chain%2C len: 164 aa%3B similar to many e.g. NARJ_BACSU nitrate reductase delta chain (EC 1.7.99.4) (184 aa)%2C fasta scores%3B opt: 208 z-score: 429.0 E(): 1.2e-16%2C 30.1%25 identity in 163 aa overlap gene gene6593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6533 SCO6534 SCO6534 narH narH 7224958 7226553 - nitrate reductase subunit beta NarH SC5C7.19c%2C narH%2C probable nitrate reductase beta chain%2C len: 531 aa%3B highly similar to many e.g. NARH_BACSU nitrate reductase beta chain (EC 1.7.99.4) (487 aa)%2C fasta scores%3B opt: 2099 z-score: 2179.2 E(): 0%2C 58.0%25 identity in 495 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature and Pfam match to entry PF00037 fer4%2C 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains%2C score 61.10%2C E-value 1.8e-16 gene gene6594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6534 SCO6535 SCO6535 narG narG 7226553 7230248 - nitrate reductase subunit alpha NarG SC5C7.20c%2C narG%2C probable nitrate reductase alpha chain%2C len: 1231 aa%3B highly similar to many e.g. NARG_BACSU nitrate reductase alpha chain (EC 1.7.99.4) (1228 aa)%2C fasta scores%3B opt: 4306 z-score: 3216.7 E(): 0%2C 51.5%25 identity in 1235 aa overlap. Contains PS00551 and PS00490 Prokaryotic molybdopterin oxidoreductases signatures 1 and 2 and Pfam match to entry PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases%2C score 79.90%2C E-value 1e-24 gene gene6595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6535 SCO6536 SCO6536 SC5C7.21c SC5C7.21c 7230397 7231212 - hypothetical protein SC5C7.21c%2C unknown%2C len: 271 aa%3B similar to two S. coelicolor hypothetical proteins SC1F2.04 (E(): 0%2C 51.3%25 identity in 269 aa overlap) and SC1F2.03c (E(): 4.5e-21%2C 44.7%25 identity in 275 aa overlap) gene gene6596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6536 SCO6537 SCO6537 SC5C7.22c SC5C7.22c 7231262 7232125 - DNA-binding protein SC5C7.22c%2C unknown%2C len: 287 aa%3B similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08%2C 29.2%25 identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251%2C +3.45 SD) gene gene6597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6537 SCO6538 SCO6538 SC5C7.23 SC5C7.23 7232354 7232779 + hypothetical protein SC5C7.23%2C probable integral membrane protein%2C len: 141 aa. Contains possible hydrophobic membrane spanning regions gene gene6598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6538 SCO6539 SCO6539 SC5C7.24c SC5C7.24c 7232761 7233579 - hypothetical protein SC5C7.24c%2C hypothetical protein%2C len: 272 aa%3B similar to TR:Q985F1 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) MLL7704 protein%2C 270 aa%3B fasta scores: opt: 786 Z-score: 877.1 E(): 3.2e-41%3B 48.638%25 identity in 257 aa overlap gene gene6599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6539 SCO6540 SCO6540 phhB phhB 7233669 7233974 + 4a-hydroxytetrahydrobiopterin dehydratase 4-alpha-hydroxytetrahydrobiopterin dehydratase activity%3B catalyzes the formation of (6R)-6-(L-erythro-1%2C2-dihydroxypropyl)-7%2C8-dihydro-6H-pterin from (6R)-6-(L-erythro-1%2C2-dihydroxypropyl)-5%2C6%2C7%2C8-tetrahydro-4a-hydroxypterin%3B functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction gene gene6600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6540 SCO6541 SCO6541 SC5C7.26 SC5C7.26 7233979 7234725 + hypothetical protein SC5C7.26%2C unknown%2C len: 248 aa%3B similar to hypothetical proteins and to TR:Q54529 (EMBL:U10405) Streptomyces purpurascens RdmD gene (required for modification on 10-position of aklavinone during anthracycline antibiotic synthesis) (237 aa)%2C fasta scores%3B opt: 162 z-score: 217.3 E(): 7.4e-05%2C 36.1%25 identity in 158 aa overlap gene gene6601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6541 SCO6542 SCO6542 SC5C7.27 SC5C7.27 7234796 7236691 + glycosyl hydrolase SC5C7.27%2C possible glycosyl hydrolase len: 631 aa%3B similar to two hypothetical proteins from B. subtilis TR:O31526 (EMBL:Z99107) yesW (620 aa)%2C fasta scores%3B opt: 2404 z-score: 2009.8 E(): 0%2C 57.7%25 identity in 620 aa overlap and TR:O31527 (EMBL:Z99107) yesX (612 aa)%2C fasta scores%3B opt: 1856 z-score: 1984.4 E(): 0%2C 54.4%25 identity in 599 aa overlap. Contains possible N-terminal signal sequence. Similar to TR:Q9AF09 (EMBL:AY026755) rhamnogalacturonan lyase from Pseudomonas cellulosa (881 aa) fasta scores%3B opt: 2392%2C Z-score: 2482.1%2C 59.091%25 identity (61.043%25 ungapped) in 594 aa overlap. gene gene6602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6542 SCO6543 SCO6543 SC5C7.28c SC5C7.28c 7236695 7236940 - hypothetical protein SC5C7.28c%2C unknown%2C len: 81 aa gene gene6603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6543 SCO6544 SCO6544 SC5C7.29 SC5C7.29 7237214 7237894 + hypothetical protein SC5C7.29%2C possible membrane protein%2C len: 226 aa%3B contains possible transmembrane domain around aa 40 gene gene6604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6544 SCO6545 SCO6545 SC5C7.30c SC5C7.30c 7237887 7240559 - cellulase SC5C7.30c%2C probable cellulase%2C len: 890 aa%3B similar to TR:D1029971 (EMBL:AB015511) Aspergillus aculeatus avicelase III (856 aa)%2C fasta scores%3B opt: 2099 z-score: 1414.5 E(): 0%2C 44.5%25 identity in 845 aa overlap%2C and to many others e.g. GUNA_MICBI endoglucanase A precursor (EC 3.2.1.4) (456 aa)%2C fasta scores%3B opt: 416 z-score: 340.7 E(): 9.9e-12%2C 28.5%25 identity in 449 aa overlap (strongest in the cellulose-binding domain). Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1%2C Cellulose binding domain%2C score 171.70%2C E-value 8.5e-49 at C-terminus gene gene6605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6545 SCO6546 SCO6546 SC5C7.31c SC5C7.31c 7240806 7243727 - cellulase SC5C7.31c%2C probable cellulase%2C len: 973 aa%3B N-terminus is similar to the cellulose binding domain of e.g. GUN4_THEFU endoglucanase E-4 precursor (880 aa)%2C fasta scores%3B opt: 341 z-score: 352.0 E(): 2.3e-12%2C 43.7%25 identity in 103 aa overlap. C-terminus is similar to many cellulases e.g. GUXB_CELFI exoglucanase B precursor (1090 aa)%2C fasta scores%3B opt: 2997 z-score: 2688.8 E(): 0%2C 61.4%25 identity in 699 aa overlap. Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1%2C Cellulose binding domain%2C score 122.30%2C E-value 2.4e-34 near N-terminus gene gene6606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6546 SCO6547 SCO6547 SC5C7.32 SC5C7.32 7244086 7244250 + hypothetical protein SC5C7.32%2C questionable ORF%2C len: 54 aa gene gene6607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6547 SCO6548 SCO6548 SC5C7.33 SC5C7.33 7244247 7245986 + cellulase SC5C7.33%2C probable cellulase%2C len: 579 aa%3B similar to many%2C e.g. TR:Q60029 (EMBL:U18978) beta-1%2C4-exocellulase precursor (596 aa)%2C fasta scores%3B opt: 2131 z-score: 2323.9 E(): 0%2C 62.1%25 identity in 585 aa overlap. Contains possible N-terminal signal sequence%2C PS00655 Glycosyl hydrolases family 6 signature 1 and Pfam match to entry PF00553 CBD_1%2C Cellulose binding domain%2C score 161.20%2C E-value 9.8e-46 near C-terminus gene gene6608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6548 SCO6549 SCO6549 SC5C7.34 SC5C7.34 7246146 7247090 + hypothetical protein SC5C7.34%2C unknow%2C len: 314 aa%3B highly His-rich in N-terminus gene gene6609 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6549 SCO6550 SCO6550 SC5C7.35 SC5C7.35 7247175 7247876 + oxidoreductase SC5C7.35%2C probable oxidoreductase%2C len: 233 aa%3B similar to many e.g. TR:O54197 (EMBL:AJ000671) Streptomyces clavuligerus clavulanate-9-aldehyde reducatase (247 aa)%2C fasta scores%3B opt: 340 z-score: 414.7 E(): 7.5e-16%2C 34.0%25 identity in 238 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C Alcohol /other dehydrogenases%2C short chain type%2C score 129.10%2C E-value 8e-35 gene gene6610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6550 SCO6551 SCO6551 SC4B5.01c SC4B5.01c 7247934 7248767 - oxidoreductase SC4B5.01c%2C probable oxidoreductase%2C len%3B 277aa%2C similar to many eg. TR:P06632 (EMBL:M12799) 2%2C5-diketo-D-gluconic acid (2%2C5-DKG) reductase from Corynebacterium sp. (278 aa)%2C fasta scores%3B opt: 938%2C z-score: 1372.7%2C E(): 0%2C (52.9%25 identity in 276 aa overlap). Contains PS00063 Aldo /keto reductase family active site signature%2C PS00062 Aldo /keto reductase family signature 2 and Pfam match to entry PF00248 aldo_ket_red%2C Aldo /keto reductase family%2C score 464.50%2C E-value 3.6e-136. gene gene6611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6551 SCO6552 SCO6552 SC4B5.02c SC4B5.02c 7248851 7250677 - long-chain-fatty-acid-CoA ligase SC4B5.02c%2C probable long-chain-fatty-acid-CoA ligase%2C len: 608aa%2C similar to many eg. TR:O53521 (EMBL:AL021957) long-chain-fatty-acid-CoA ligase from Mycobacterium tuberculosis (600 aa)%2C fasta scores%3B opt: 1177%2C z-score: 1838.1%2C E(): 0%2C (44.8%25 identity in 612 aa overlap). Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme%2C score -73.00%2C E-value 7.8e-11 and PS00455 AMP-binding domain signature. gene gene6612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6552 SCO6553 SCO6553 SC4B5.03c SC4B5.03c 7250906 7252420 - integral membrane efflux protein SC4B5.03c%2C probable integral membrane efflux protein%2C len: 504aa%3B similar to a family of integral membrane transport proteins most of which appear to be concerned with export of antimicrobial compounds%2C most similar to SW:TCMA_STRGA tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa)%2C fasta scores%3B opt: 790%2C z-score: 800.0%2C E(): 0%2C (33.8%25 identity in 497 aa overlap). Contains PS00216 Sugar transport proteins signature 1. Also contains several membrane spanning regions. gene gene6613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6553 SCO6554 SCO6554 SC4B5.04 SC4B5.04 7252536 7253519 + transcriptional regulator SC4B5.04%2C probable transcriptional regulatory protein%2C len: 327 aa%3B C-terminal region weakly similar to several members of the asnC family of transcriptional regulators e.g. SW:Y723_METJA transcriptional regulatory protein from Methanococcus jannaschii (156 aa)%2C fasta scores%3B opt: 167%2C z-score: 267.8%2C E(): 1.3e-07%2C (24.1%25 identity in 141 aa overlap). Contains probable helix-turn-helix motif (score 1226%2C +3.36 SD) from residue 198 to 219. gene gene6614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6554 SCO6555 SCO6555 SC4B5.05c SC4B5.05c 7253501 7254379 - LysR family transcriptional regulator SC4B5.05c%2C LysR-family transcriptional regulator%2C len: 295 aa%3B similar to several members of the LysR family of transcriptional regulators eg. TR:G3273739 (EMBL:AF057064) HexA from Erwinia carotovora subspecies atroseptica (316 aa)%2C fasta scores%3B opt: 453%2C z-score: 562.2%2C E(): 5.1e-24%2C (32.6%25 identity in 276 aa overlap). Contains PS00044 Bacterial regulatory proteins%2C lysR family signature%2C PS00287 Cysteine proteases inhibitors signature and Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix proteins%2C lysR family%2C score 143.70%2C E-value 3.3e-39. Contains strong helix-turn-helix motif (score 2054%2C +6.18 SD) at residue18 10 39. gene gene6615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6555 SCO6556 SCO6556 SC4B5.06 SC4B5.06 7254532 7255569 + transmembrane protein SC4B5.06%2C possible transmembrane protein%2C similar to SW:YFEH_ECOLI Hypothetical protein from Escherichia coli%2C (332 aa)%2C fasta scores%3B opt: 985%2C z-score: 1173.2%2C E(): 0%2C (48.9%25 identity in 323 aa overlap). Hydrophobic with several possible membrane spanning regions. gene gene6616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6556 SCO6557 SCO6557 SC4B5.07c SC4B5.07c 7255596 7257542 - neuramidase SC4B5.07c%2C possible neuraminidase (hypothetical protein)%2C len: 648 aa%3B similar to several e.g. TR:D1001316 (EMBL:D01045) neuraminidase from Micromonospora viridifaciens (647 aa) fasta scores%3B opt: 286%2C z-score: 289.0%2C E(): 8.4e-09%2C (30.4%25 identity in 598 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene6617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6557 SCO6558 SCO6558 SC4B5.08c SC4B5.08c 7257738 7258586 - formate dehydrogenase accessory protein involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth gene gene6618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6558 SCO6559 SCO6559 SC4B5.09c SC4B5.09c 7258619 7259479 - respiratory chain oxidoreductase SC4B5.09c%2C respiratory chain oxidoreductase%2C len: 286 aa%3B similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa)%2C fasta scores%3B opt: 685%2C z-score: 791.8%2C E(): 0%2C (38.4%25 identity in 284 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1%2C PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature%2C PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature%2C Pfam match to entry PF00037 fer4%2C 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains%2C score 40.00%2C E-value 2.4e-10 and Pfam match to entry PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains%2C score -5.70%2C E-value 0.11. Considering the corresponding homologies%2C this CDS may have previously been located directly upsteam of SC4B5.11c gene gene6619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6559 SCO6560 SCO6560 SC4B5.10c SC4B5.10c 7259476 7261416 - respiratory chain oxidoreductase SC4B5.10c%2C respiratory chain oxidoreductase%2C len: 646 aa%3B C-terminal region is similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:O27592 (EMBL:AE000915) NADP-reducing hydrogenase%2C subunit C from Methanobacterium thermoautotrophicum (630 aa)%2C fasta scores%3B opt: 121%2C4 z-score: 1170.7%2C E(): 0%2C (47.1%25 identity in 397 aa overlap). Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. gene gene6620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6560 SCO6561 SCO6561 SC4B5.11c SC4B5.11c 7261448 7263376 - respiratory chain oxidoreductase SC4B5.11c%2C respiratory chain oxidoreductase%2C len: 642 aa%3B similar to the C-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa) fasta scores%3B opt: 1532%2C z-score: 1338.5%2C E(): 0%2C (43.1%25 identity in 619 aa overlap). Contains Pfam match to entry PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases%2C score 95.80%2C E-value 6.2e-30. Considering the corresponding homolgies%2C this CDS may have previously been located directly downsteam of SC4B5.09c. gene gene6621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6561 SCO6562 SCO6562 SC4B5.12c SC4B5.12c 7263373 7264344 - 2-dehydropantoate 2-reductase ketopantoate reductase%3B catalyzes the NADPH reduction of ketopantoate to pantoate%3B functions in pantothenate (vitamin B5) biosynthesis gene gene6622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6562 SCO6563 SCO6563 SC4B5.13 SC4B5.13 7264548 7265888 + integral membrane transporter SC4B5.13%2C probable integral membrane transporter%2C len: 446aa%3B similar to several eg. TR:Q51330 (EMBL:U40075) OxlT%2C the oxalate:formate exchange protein from Oxalobacter formigenes (418 aa)%2C fasta scores%3B opt: 243%2C z-score: 382.3%2C E(): 5.3e-14%2C (26.1%25 identity in 421 aa overlap). Contains several possible membrane spanning regions. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter%2C score -99.90%2C E-value 0.013. gene gene6623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6563 SCO6564 SCO6564 fabH2 fabH2 7266172 7267122 + 3-oxoacyl-ACP synthase III FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs gene gene6624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6564 SCO6565 SCO6565 SC4B5.15 SC4B5.15 7267256 7267933 + transcriptional regulator SC4B5.15%2C probable transcriptional regulator%2C len: 225aa%3B similar to many hypothetical /transcriptional regulators e.g. TR:O50514 (EMBL:AL009204) probable transcriptional regulator from Streptomyces coelicolor (231 aa)%2C fasta scores%3B opt: 322%2C z-score: 457.0%2C E(): 3.7e-18%2C (35.2%25 identity in 199 aa overlap) and TR:P77347 (EMBL:D90785) NTA operon transcriptional regulator from Escherichia coli (221 aa)%2C fasta scores%3B opt: 233%2C z-score: 348.7%2C E(): 4e-12%2C (27.1%25 identity in 192 aa overlap). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family%2C score 56.90%2C E-value 5e-16. gene gene6625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6565 SCO6566 SCO6566 SC3F9.01 SC3F9.01 7267996 7269378 + ROK family protein SC3F9.01%2C unknown%2C partial CDS%2C len: >403 aa%3B similar to many members of the ROK (nagC/xylR) family e.g. NAGC_ECOLI N-acetylglucosamine repressor (406 aa)%2C fasta scores%3B opt: 513 z-score: 578.8 E(): 5e-25%2C 28.6%25 identity in 388 aa overlap and GLK_STRCO glucokinase (EC 2.7.1.2) (glucose kinase) (317 aa)%2C fasta scores%3B opt: 544 z-score: 570.9 E(): 1.4e-24%2C 34.4%25 identity in 317 aa overlap. Contains PS01125 ROK family signature and Pfam match to entry ROK PF00480%2C ROK family%2C score 164.11. Also similar to S. coelicolor SC7B7.05%2C probable transcriptional repressor (E(): 9.6e-25%2C 34.3%25 identity in 385 aa overlap)~SC4B5.16%2C possible ROK family protein%2C partial CDS%2C len: 92aa%3B forms the C-terminal region of TR:O69941 (EMBL:AL023862) partial CDS%2C hypothetical ROK family protein on adjacent cosmid 3F9 from Streptomyces coelicolor (403 aa). gene gene6626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6566 SCO6567 SCO6567 SC3F9.02 SC3F9.02 7269589 7271106 + ABC transporter ATP-binding protein SC3F9.02%2C ABC transporter ATP binding protein%2C len:505 aa%3B similar to many sugar transport proteins e.g. ARAG_ECOLI l-arabinose transport atp-binding protein (504 aa)%2C fasta scores%3B opt: 1312 z-score: 1412.8 E(): 0%2C 42.1%25 identity in 501 aa overlap andRBSA_HAEIN ribose transport atp-binding protein rbsA (493 aa)%2C fasta scores%3B opt: 1160 z-score: 1216.7 E(): 0%2C 40.7%25 identity in 489 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and Pfam match to entry ABC_tran PF00005%2C ABC transporters%2C score 197.70 gene gene6627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6567 SCO6568 SCO6568 SC3F9.03 SC3F9.03 7271103 7272122 + ABC transporter SC3F9.03%2C ABC transporter integral membrane protein%2C len: 339 aa%3B similar to many involved in sugar transport e.g. RBSC_BACSU ribose transport system permease (323 aa)%2C fasta scores%3B opt: 700 z-score: 958.9 E(): 0%2C 39.5%25identity in 314 aa overlap gene gene6628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6568 SCO6569 SCO6569 SC3F9.04 SC3F9.04 7272140 7273186 + solute binding protein SC3F9.04%2C probable solute binding protein%2C len: 348 aa%3B similar to many e.g. RBSB_HAEIN D-ribose-binding periplasmic protein precursor (292 aa)%2C fasta scores%3B opt: 341 z-score: 284.7 E(): 1.2e-08%2C 29.2%25 identity in 271 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6569 SCO6570 SCO6570 SC3F9.05 SC3F9.05 7273272 7274564 + oxidoreductase SC3F9.05%2C possible oxidoreductase%2C len: 430 aa%3B similar to e.g. Zymomonas mobilisTR:P75002 (EMBL:Z80356) glucose-fructose oxidoreductase (433 aa)%2C fasta scores%3B opt: 310 z-score: 305.5 E(): 8.4e-10%2C 27.2%25 identity in 426 aa overlap gene gene6630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6570 SCO6571 SCO6571 SC3F9.06 SC3F9.06 7274581 7275579 + DNA-binding protein SC3F9.06%2C possible DNA-binding protein%2C len: 332 aa%3B similar to TR:Q9A7T9 (EMBL:AE005838) Caulobacter crescentus hypothetical protein CC1631%2C 351 aa%3B fasta scores: opt: 552 Z-score: 641.5 E(): 4.2e-28%3B 34.940%25 identity in 332 aa overlap. Contains possible helix-turn-helix motif at residues 55 to 76 (Score 1148%2C +3.10 SD) gene gene6631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6571 SCO6572 SCO6572 SC3F9.07 SC3F9.07 7275867 7279583 + glycosyl hydrolase SC3F9.07%2C possible glycosyl hydrolase (hypothetical protein)%2C len: 1238 aa%3B similar to TR:Q9K473 (EMBL:AL359215) glycosyl hydrolase from Streptomyces coelicolor (962 aa) fasta scores%3B opt: 3614%2C Z-score: 3774.0%2C 63.899%25 identity (65.074%25 ungapped) in 831 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene6632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6572 SCO6573 SCO6573 SC3F9.08 SC3F9.08 7279753 7281006 + hypothetical protein SC3F9.08%2C probable hypothetical protein%2C len: 417 aa%3B some similarity to many eukaryotic myo-inositol-1-phosphate synthases e.g. INO1_SPIPO (510 aa)%2C fasta scores%3B opt: 159 z-score: 190.1 E(): 0.0022%2C 28.1%25 identity in 423 aa overlap%2C and to Archaeoglobus fulgidus TR:O28480 (EMBL:AE000979) AF1794 (392 aa)%2C fasta scores%3B opt: 546 z-score: 713.5 E(): 1.6e-32%2C 37.0%25 identity in 397 aa overlap. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene6633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6573 SCO6574 SCO6574 SC3F9.09 SC3F9.09 7281003 7282094 + hypothetical protein SC3F9.09%2C membrane protein%2C len: 363 aa%3B similar to TR:Q9Z4Y9 (EMBL:AL035707) Streptomyces coelicolor transferase SCE29.11c%2C 291 aa%3B fasta scores: opt: 666 Z-score: 604.6 E(): 4.8e-26%3B 51.282%25 identity in 312 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6574 SCO6575 SCO6575 SC3F9.10 SC3F9.10 7282091 7283038 + hypothetical protein SC3F9.10%2C unknown%2C len: 315 aa%3B some similarity to MOCC_RHIME rhizopine catabolism protein MocC (325 aa)%2C fasta scores%3B opt: 127 z-score: 216.9 E(): 7.2e-05%2C 33.5%25 identity in 167 aa overlap gene gene6635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6575 SCO6576 SCO6576 SC3F9.11 SC3F9.11 7283052 7283789 + hypothetical protein SC3F9.11%2C unknown%2C len: 245 aa%3B sim ilar to another from Streptomyces coelicolor TR:Q9Z4Z1 (EMBL:AL035707) SCE29.09C (236 aa) fasta scores%3B opt: 416%2C Z-score: 467.6%2C E(): 2.1e-18%2C 45.455%25 identity (52.083%25 ungapped) in 220 aa overlap . gene gene6636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6576 SCO6577 SCO6577 SC3F9.12 SC3F9.12 7283789 7284637 + hypothetical protein SC3F9.12%2C unknown%2C len: 282 aa%3B similar to hypothetical proteins from several organisms e.g. YD83_METJA MJ1383(256 aa)%2C fasta scores%3B opt: 347 z-score: 391.9 E(): 1.3e-14%2C 28.5%25 identity in 260 aa overlap gene gene6637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6577 SCO6578 SCO6578 SC3F9.13 SC3F9.13 7284641 7285816 + hypothetical protein SC3F9.13%2C unknown%2C len: 391 aa%3B contains PS00730 AP endonucleases family 2 signature 2 gene gene6638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6578 SCO6579 SCO6579 SC3F9.14 SC3F9.14 7285813 7287210 + hypothetical protein SC3F9.14%2C unknown%2C len: 465 aa%2C similar to TR:Q9Z4Z4 (EMBL:AL035707) hypothetical protein from Streptomyces coelicolor (462 aa) fasta scores%3B opt: 2206%2C Z-score: 2466.5%2C 70.575%25 identity (70.889%25 ungapped) in 452 aa overlap. gene gene6639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6579 SCO6580 SCO6580 SC3F9.15 SC3F9.15 7287325 7288539 + hypothetical protein SC8A6.01%2C unknown%2C partial CDS%2C len: >215 aa%3B overlaps and extends SC3F9.15~SC3F9.15%2C unknown%2C partial CDS len: >224 aa gene gene6640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6580 SCO6581 SCO6581 SCO6581 7288619 7290049 - transmembrane transport protein SC8A6.02c%2C probable transmembrane transport protein%2C len: 476 aa%3B some similarity to e.g. TR:Q51330 (EMBL:U4007 5) oxalate:formate antiport protein from Oxalobacter formig enes (418 aa)%2C fasta scores%3B opt: 226 z-score: 230.1 E(): 1 .4e-05%2C 24.1%25 identity in 436 aa overlap gene gene6641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6581 SCO6582 SCO6582 SCO6582 7290122 7292266 - hypothetical protein SC8A6.03c%2C unknown%2C len: 714 aa%3B similar to many hypothetical proteins including several from each of the arche ons Archaeoglobus fulgidus TR:O28341 (EMBL:AE000970) conser ved hypothetical protein AF1938(673 aa)%2C fasta scores%3B opt: 960 z-score: 1289.8 E(): 0%2C 35.6%25 identity in 693 aa overl ap and Pyrococcus horikoshii D1028624 (EMBL:AB009518) hypot hetical protein PHCV016 (460 aa)%2C fasta scores%3B opt: 1280 z -score: 1246.9 E(): 0%2C 44.3%25 identity in 461 aa overlap. Co ntains PS00216 Sugar transport proteins signature 1. Also s imilar to S. coelicolor hypothetical protein SC9B10.09 (E() : 6.1e-15%2C 33.9%25 identity in 375 aa overlap) gene gene6642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6582 SCO6583 SCO6583 SCO6583 7292271 7293503 - formyl-coenzyme A transferase catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA gene gene6643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6583 SCO6584 SCO6584 SCO6584 7293515 7295197 - TPP-requiring enzyme SC8A6.05c%2C probable TPP-requiring enzyme%2C len: 560 a a%3B similar to many e.g. ILVB_MYCTU probable acetolactate synthase (EC 4.1.3.18) (547 aa)%2C fasta scores%3B opt: 733 z-sco re: 1305.6 E(): 0%2C 36.4%25 identity in 557 aa overlap. Contai ns PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes%2C Thiamine pyrophosphate enzymes%2C score 343.90%2C E-value 5e-106 gene gene6644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6584 SCO6585 SCO6585 sucC sucC 7295341 7296492 + succinyl-CoA synthetase subunit beta catalyzes the interconversion of succinyl-CoA and succinate gene gene6645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6585 SCO6586 SCO6586 SCO6586 7296507 7297433 + succinyl-CoA synthetase subunit alpha Catalyzes the only substrate-level phosphorylation in the TCA cycle gene gene6646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6586 SCO6587 SCO6587 SCO6587 7297430 7298992 + dehydrogenase SC8A6.08%2C probable dehydrogenase%2C len: 520 aa%3B some similarity to many diverse dehydrogenases%2C e.g. SSDH_RAT su ccinate semialdehyde dehydrogenase (488 aa)%2C fasta scores%3B opt: 308 z-score: 301.8 E(): 1.4e-09%2C 26.0%25 identity in 439 aa overlap gene gene6647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6587 SCO6588 SCO6588 SCO6588 7299120 7300451 - hypothetical protein SC8A6.09c%2C unknown%2C len: 443 aa%3B some similarity to M. tuberculosis hypothetical protein Y029_MYCTU MTCY373.09 C (521 aa)%2C fasta scores%3B opt: 371 z-score: 502.3 E(): 9.7e -21%2C 28.3%25 identity in 446 aa overlap gene gene6648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6588 SCO6589 SCO6589 fusA fusA 7301063 7303123 + elongation factor G EF-G%3B promotes GTP-dependent translocation of the ribosome during translation%3B many organisms have multiple copies of this gene gene gene6650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6589 SCO6590 SCO6590 SCO6590 7303361 7305568 - esterase SC8A6.11c%2C probable esterase%2C len: 735 aa%3B similar to TR:Q54345 (EMBL:Z50108) esterase precursor from Streptomyces lividans (509 aa)%2C fasta scores%3B opt: 553 z-sc ore: 526.3 E(): 4.5e-22%2C 38.2%25 identity in 403 aa overlap a nd to other membres of the trypsin family. Contains probabl e N-terminal signal sequence and Pfam match to entry PF0008 9 trypsin%2C Trypsin%2C score 31.60%2C E-value 4.4e-07 gene gene6651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6590 SCO6591 SCO6591 SCO6591 7305602 7306108 - hypothetical protein SC8A6.12c%2C possible hypothetical protein%2C len: 168 aa%3B c ontains possible N-terminal signal sequence gene gene6652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6591 SCO6592 SCO6592 SCO6592 7306230 7306619 - hypothetical protein SC8A6.13c%2C probable hypothetical protein%2C len: 129 aa%3B c ontains N-terminal signal sequence and appropriately positi oned PS00013 Prokaryotic membrane lipoprotein lipid attachm ent site gene gene6653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6592 SCO6593 SCO6593 SCO6593 7306616 7310059 - hypothetical protein SC8A6.14c%2C unknown%2C len: 1147 aa%3B contains two Ala-rich domains%2C PS00017 ATP/GTP-binding site motif A (P-loop) and probable coiled-coil regions from 238 to 292%2C 399 to 441%2C 445 to 488%2C 490 to 573%2C 786 to 820%2C and 829 to 871 gene gene6654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6593 SCO6594 SCO6594 SCO6594 7310408 7312216 - hypothetical protein SC8A6.15c%2C probable hypothetical protein%2C len: 602 aa%3B c ontains probable N-terminal signal sequence gene gene6655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6594 SCO6595 SCO6595 SCO6595 7312483 7313565 + hypothetical protein SC8A6.16%2C probable hypothetical protein%2C len: 380 aa%3B co ntains N-terminal signal sequence and TTA Leu codon%2C possib le target for action of bldA gene gene6656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6595 SCO6596 SCO6596 SCO6596 7313660 7315429 + hypothetical protein SC8A6.17%2C probable hypothetical protein%2C len: 589 aa%3B co ntains N-terminal signal sequence and PS00213 Lipocalin sig nature gene gene6657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6596 SCO6597 SCO6597 SCO6597 7315461 7318040 + beta-glucosidase SC8A6.18%2C probable beta-glucosidase%2C len: 859 aa%3B si milar to many e.g. BGLS_AGRTU beta-glucosidase (EC 3.2.1.21 ) (818 aa)%2C fasta scores%3B opt: 810 z-score: 1139.9 E(): 0%2C 37.2%25 identity in 862 aa overlap gene gene6658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6597 SCO6598 SCO6598 SC8A6.19 SC8A6.19 7318137 7319177 + transcriptional regulator SC8A6.19%2C probable transcriptional regulator%2C len: 246 aa%3B similar to many members of the lacI family%2C e.g. CCP A_BACSU glucose-resistance amylase regulator (334 aa)%2C fast a scores%3B opt: 313 z-score: 569.6 E(): 1.7e-24%2C 31.2%25 identity in 317 aa overlap. Contains PS00356 Bacterial regulatory proteins%2C lacI family signature%2C helix-tur-helix motif at aa 7-28 (Score 2389%2C +7.32 SD) and Pfam matches to entry P F00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family%2C score 86.50%2C E-value 5.3e-22 and Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family%2C score 43.00%2C E-value 1e-10 gene gene6659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6598 SCO6599 SCO6599 SC8A6.20c SC8A6.20c 7319193 7319846 - transcriptional regulator SC8A6.20c%2C probable transcriptional regulator%2C len: 217 aa%3B some similarity to members of the tetR family e.g. TER4_ECOLI tetracycline repressor protein class D (217 aa)%2C fasta scores%3B opt: 158 z-score: 233.4 E(): 9.2e-06%2C 35.2%25 identity in 88 aa overlap. Contains probable helix-turn-helix motif at aa 29-50 (Score 1279%2C +3.54 SD) and Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family%2C score 31.90%2C E-value 4.2e-07 gene gene6660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6599 SCO6600 SCO6600 SC8A6.21c SC8A6.21c 7320012 7321337 - transcriptional regulator SC8A6.21c%2C probable transcriptional regulator%2C len: 441 aa%3B some similarity to members of the ROK family e.g. XYLR_ANATH xylose repressor (399 aa)%2C fasta scores%3B opt: 365 z-score: 361.7 E(): 6.6e-13%2C 27.2%25 identity in 397 aa over lap. Contains Pfam match to entry PF00480 ROK%2C ROK family%2C score 38.10%2C E-value 3e-10 gene gene6661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6600 SCO6601 SCO6601 SCO6601 7321513 7322829 + sugar binding protein SC8A6.22%2C probable sugar binding protein%2C l en: 438 aa%3B similar to e.g. S. coelicolor TR:P72397 (EMBL:Y 07706) maltose-binding pootein malE (423 aa)%2C fast a scores%3B opt: 425 z-score: 307.7 E(): 6.7e-10%2C 28.9%25 ident ity in 439 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane l ipoprotein lipid attachment site gene gene6662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6601 SCO6602 SCO6602 SCO6602 7322891 7323919 + transmembrane sugar transport protein SC8A6.23%2C probable transmembrane sugar transport pro tein%2C len: 342 aa%3B similar to e.g. S. coelicolor TR:P72398 (EMBL:Y07706) maltose permease malF (334 aa)%2C fast a scores%3B opt: 494 z-score: 521.6 E(): 8.2e-22%2C 32.6%25 ident ity in 322 aa overlap. Contains PS00017 ATP/GTP-binding sit e motif A (P-loop)%2C PS00402 Binding-protein-dependent trans port systems inner membrane comp signature and Pfam match t o entry PF00528 BPD_transp%2C Binding-protein-dependent trans port systems inner membrane component%2C score 42.00%2C E-value 1.3e-08 gene gene6663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6602 SCO6603 SCO6603 SCO6603 7323927 7324766 + transmembrane sugar transport protein SC8A6.24%2C probable transmembrane sugar transport pro tein%2C len: 279 aa%3B similar to e.g. S. coelicolor TR:P72399 (EMBL:Y07706) maltose permease malG (302 aa)%2C fast a scores%3B opt: 542 z-score: 755.1 E(): 0%2C 36.7%25 identity in 270 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature and Pfam m atch to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C score 75.20%2C E -value 1.3e-18 gene gene6664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6603 SCO6604 SCO6604 SC1F2.01 SC1F2.01 7324763 7326169 + beta-glucosidase SC1F2.01%2C probable beta-glucosidase%2C partial CDS%2C len >311 aa%3B similar to mnay e.g. BGLS_AGRSP beta-glucosidase (EC 3.2.1.21) (459 aa)%2C fasta scores%3B opt: 784 z-score: 986.7 E(): 0%2C 42.5%25 identity in 315 aa overlap. Overlaps and extends SC8A6.25. Contains Pfam match to entry PF00232 glycosyl_hydro1%2C Glycosyl hydrolases family 1%2C score 350.20%2C E-value 2.2e-101~SC8A6.25%2C probable beta-glucosidase%2C partial CDS%2C le n >190 aa%3B highly similar to many e.g. BGLA_BACCI beta-glucosidase (EC 3.2.1.21) (449 aa)%2C fasta scores%3B opt: 752 z-sc ore: 1084.7 E(): 0%2C 59.9%25 identity in 167 aa overlap. Conta ins PS00653 Glycosyl hydrolases family 1 N-terminal signatu re and Pfam match to entry PF00232 glycosyl_hydro1%2C Glycosy l hydrolases family 1%2C score 348.50%2C E-value 7.3e-101 gene gene6665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6604 SCO6605 SCO6605 SCO6605 7326284 7326469 + gene gene6666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6605 SCO6606 SCO6606 SC1F2.03c SC1F2.03c 7326508 7327410 - hypothetical protein SC1F2.03c%2C unknown%2C len: 300 aa%3B similar to upstream gene SC1F3.04%2C E(): 0%2C 48.8%25 identity in 260 aa overlap anbd to TR:Q9L173 (EMBL:AL158057) Streptomyces coelicolor hypothetical protein SC10G8.32c%2C 263 aa%3B fasta scores: opt: 791 Z-score: 879.8 E(): 2.3e-41%3B 49.237%25 identity in 262 aa overlap gene gene6667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6606 SCO6607 SCO6607 SC1F3.04 SC1F3.04 7327541 7328326 + hypothetical protein SC1F3.04%2C unknown%2C len: 261 aa%3B similar to many Streptomyces coelicolor e.g. upstream gene SC1F2.03c%2CE(): 0%2C 48.8%25 identity in 260 aa overlap gene gene6668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6607 SCO6608 SCO6608 SC1F2.05 SC1F2.05 7328456 7330114 + hypothetical protein SC1F2.05%2C probable hypothetical protein%2C len: 552 aa%3B contains N-terminal signal sequence gene gene6669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6608 SCO6609 SCO6609 SC1F2.06 SC1F2.06 7330247 7331275 + hypothetical protein SC1F2.06%2C probable hypothetical protein%2C len: 342 aa%3B some similatity to antigenic proteins 85A%2C 85B and 85C from Mycobacteria e.g. A85B_MYCLE (327 aa)%2C fasta scores%3B opt: 325 z-score: 247.2 E(): 1.6e-06%2C 28.5%25 identity in 319 aa overlap and to antigenic protein PS1 from Cornebacterium glutamicum CSP1_CORGL (657 aa)%2C fasta scores%3B opt: 479 z-score: 421.7 E(): 3e-16%2C 28.2%25 identity in 333 aa overlap. Contains possible N-terminal signal sequence gene gene6670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6609 SCO6610 SCO6610 SC1F2.07 SC1F2.07 7331426 7332799 + hypothetical protein SC1F2.07%2C probable hypothetical protein%2C len: 457 aa%3B contains N-terminal signal sequence. Also contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature and Pfam match to entry PF00099 zn-protease%2C Zinc-binding metalloprotease domain%2C score 15.20%2C E-value 0.81%3B but no apparent similarities to proteases. Also contains possible helix-turn-helix motif at aa 378-399 (Score 1335%2C +3.73 SD) gene gene6671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6610 SCO6611 SCO6611 SC1F2.08c SC1F2.08c 7332818 7333378 - hypothetical protein SC1F2.08c%2C unknown%2C len: 186 aa gene gene6672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6611 SCO6612 SCO6612 SC1F2.09c SC1F2.09c 7333403 7334332 - hydrolase SC1F2.09c%2C probable hydrolase%2C len: 309 aa%3B similar to many e.g. XYLF_PSEPU 2-hydroxymuconic semialdehyde hydrolase (281 aa)%2C fasta scores%3B opt: 236 z-score: 348.2 E(): 3.8e-12%2C 29.0%25 identity in 283 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha /beta hydrolase fold%2C score 52.80%2C E-value 7.5e-12 gene gene6673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6612 SCO6613 SCO6613 SC1F2.10 SC1F2.10 7334456 7334863 + hypothetical protein SC1F2.10%2C unknown%2C len: 135 aa%3B similar to hypothetical proteins from several organisms e.g. YTFH_ECOLI (156 aa)%2C fasta scores%3B opt: 315 z-score: 460.2 E(): 2.2e-18%2C 40.5%25 identity in 116 aa overlap gene gene6674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6613 SCO6614 SCO6614 SC1F2.11 SC1F2.11 7335116 7336225 + hypothetical protein SC1F2.11%2C probable membrane protein%2C len: 369 aa%3B contains a possible transmembrane domain around aa 100 gene gene6675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6614 SCO6615 SCO6615 SC1F2.12 SC1F2.12 7336237 7337439 + hypothetical protein SC1F2.12. unknown%2C len: 400 aa gene gene6676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6615 SCO6616 SCO6616 SC1F2.13c SC1F2.13c 7337453 7338883 - hypothetical protein SC1F2.13c%2C hypothetical protein%2C len: 476 aa%3B similar to several proteins from M. tuberculosis e.g. TR:O05897 (EMBL:Z95121) hypothetical protein MTCY20B11.29 (462 aa)%2C fasta scores%3B opt: 573 z-score: 448.5 E(): 9.7e-18%2C 32.3%25 identity in 400 aa overlap. Contains possible N-terminal signal sequence gene gene6677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6616 SCO6617 SCO6617 SC1F2.14c SC1F2.14c 7338876 7339205 - hypothetical protein SC1F2.14c%2C unknown%2C len: 109 aa gene gene6678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6617 SCO6618 SCO6618 SC1F2.15c SC1F2.15c 7339269 7339949 - hypothetical protein SC1F2.15c%2C unknown%2C len: 226 aa gene gene6679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6618 SCO6619 SCO6619 SC1F2.16c SC1F2.16c 7339983 7340813 - dehydrogenase SC1F2.16c%2C probable dehydrogenase%2C len: 276 aa%3B similar to many e.g. TR:O24479 (EMBL:U89510) B-keto acyl reductase from Hordeum vulgare (barley) (325 aa)%2C fasta scores%3B opt: 316 z-score: 468.7 E(): 7.2e-19%2C 36.4%25 identity in 214 aa overlap and HETN_ANASP ketoacyl reductase hetN (287 aa)%2C fasta scores%3B opt: 343 z-score: 416.6 E(): 5.8e-16%2C 36.8%25 identity in 220 aa overlap. Contains PS00061 Short-chain dehydrogenases reductases to entry PF00106 adh_short%2C Alcohol /other dehydrogenases%2C short chain type%2C score 166.30%2C E-value 5.1e-46 gene gene6680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6619 SCO6620 SCO6620 SC1F2.17 SC1F2.17 7340945 7341376 + hypothetical protein SC1F2.17%2C hypothetical protei%2C len: 143 aa%3B similar to hypothetical proteins e.g. M. tuberculosis TR:P71885 (EMBL:Z79702) MTCY3G12.07C (163 aa)%2C fasta scores%3B opt: 171 z-score: 244.4 E(): 2.3e-06%2C 36.0%25 identity in 114 aa overlap gene gene6681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6620 SCO6621 SCO6621 SC1F2.18 SC1F2.18 7341633 7342907 + hypothetical protein SC1F2.18%2C unknown%2C len: 424 aa%3B some similarity to C-terminus of TR:O54229 (EMBL:AJ223176) Streptomyces granaticolor Ser/Thr protein kinase (780 aa)%2C fasta scores%3B opt: 260 z-score: 221.0 E(): 4.5e-05%2C 27.8%25 identity in 439 aa overlap gene gene6682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6621 SCO6622 SCO6622 SC1F2.19 SC1F2.19 7343142 7345028 + ATP/GTP binding protein SC1F2.19%2C probable ATP/GTP binding protein%2C len: 628 aa%3B very weak similarity in C-terminus to a yeast ATP /GTP binding protein TR:Q12179 (EMBL:Z73601) Saccharomyces cerevisiae chromosome XVI ORF YPL245W (454 aa)%2C fasta scores%3B opt: 201 z-score: 198.6 E(): 0.00081%2C 25.2%25 identity in 469 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop) and PS00152 ATP synthase alpha and beta subunits signature. Also similar to downstream gene SC1F2.20%2C E(): 0%2C 37.1%25 identity in 657 aa overlap gene gene6683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6622 SCO6623 SCO6623 SC1F2.20 SC1F2.20 7345061 7347256 + ATP/GTP binding protein SC1F2.20%2C probable ATP/GTP binding protein%2C len: 731 aa%3B very weak similarity in C-terminus to a yeast ATP /GTP binding protein TR:Q12179 (EMBL:Z73601) Saccharomyces cerevisiae chromosome XVI ORF YPL245W (454 aa)%2C Smith-Waterman scores%3BE: 3.1e-05%2C 20.4%25 identity in 499 aa overlap. Contains two TTA Leu codons: possible targets for action of bldA%2C PS00017 ATP /GTP-binding site motif A (P-loop) and a possible N-terminal signal sequence. Also similar to upstream gene SC1F2.19%2C E(): 0%2C 37.1%25 identity in 657 aa overlap gene gene6684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6623 SCO6624 SCO6624 SC1F2.21c SC1F2.21c 7347312 7347440 - hypothetical protein SC1F2.21c%2C membrane protein%2C len: 42 aa%3B hydrophobic in C-terminus. Contains possible hydrophobic membrane spanning regions gene gene6685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6624 SCO6625 SCO6625 SC1F2.22 SC1F2.22 7347655 7348320 + hypothetical protein SC1F2.22%2C unknown%2C len: 221 aa gene gene6686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6625 SCO6626 SCO6626 SC1F2.23 SC1F2.23 7348537 7353210 + protein kinase SC1F2.23%2C unknown%2C len: 1557 aa%3B some simlarity to several protein kinases e.g. ABL_MLVAB tyrosine-protein kinase transforming protein from Abelson murine leukemia virus (746 aa)%2C fasta scores%3B opt: 84 z-score: 234.0 E(): 8.6e-06%2C 24.7%25 identity in 364 aa overlap. Contains PS00107 Protein kinases ATP-binding region signature%2C Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain%2C score 18.10%2C E-value 0.00062 and possible helix-turn-helix motif at aa 1027-1048 (Score 1753%2C +5.16 SD) gene gene6687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6626 SCO6627 SCO6627 SC1F2.24 SC1F2.24 7353207 7356839 + hypothetical protein SC4G2.01%2C unknown%2C partial CDS%2C len: >378 aa%3B continuation of SC1F2.24~SC1F2.24%2C unknown%2C partial CDS%2C len: >862 aa%3B contains short segment of similarity to a Helicobacter pylori gene described as TR:O26046 (EMBL:AE000649) type IIS restriction enzyme R and M protein (1279 aa)%2C fasta scores%3B opt: 92 z-score: 267.0 E(): 1.3e-07%2C 30.5%25 identity in 118 aa overlap. Also contains PS00092 N-6 Adenine-specific DNA methylases signature and probable coiled-coil from a 5-39. Note that this CDS is relatively more AT rich (approx 60%25 GC) than the genomic average (72%25) gene gene6688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6627 SCO6628 SCO6628 SC4G2.02c SC4G2.02c 7356766 7357356 - hypothetical protein SC4G2.02c%2C unknown%2C len: 196 aa%3B similar to S. coelicolor TR:Q53897 (EMBL:X60316) abaA gene ORFA (192 aa)%2C fasta scores%3B opt: 245 z-score: 250.4 E(): 1.1e-06%2C 32.9%25 identity in 164 aa overlap. Also similar to SC10A5.20 (32.7%25 identity in 147 aa overlap) and SC7C7.02c (38.7%25 identity in 150 aa overlap) and to TR:Q9RKV5 (EMBL:AL132824) Streptomyces coelicolor regulatory protein SCAH10.02%2C 160 aa%3B fasta scores: opt: 436 Z-score: 526.8 E(): 1e-21%3B 51.449%25 identity in 138 aa overlap gene gene6689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6628 SCO6629 SCO6629 SC4G2.03 SC4G2.03 7357519 7358352 + hypothetical protein SC4G2.03%2C hypothetical protein%2C len: 277 aa%3B similar to TR:Q9F345 (EMBL:AL391751) Streptomyces coelicolor hypothetical protein SC9E12.10c%2C 287 aa%3B fasta scores: opt: 769 Z-score: 890.8 E(): 5.5e-42%3B 48.736%25 identity in 277 aa overlap gene gene6690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6629 SCO6630 SCO6630 SC4G2.04 SC4G2.04 7358349 7358552 + hypothetical protein SC4G2.04%2C unknown%2C len: 67 aa%3B similar to S. coelicolor TR:Q53896 (EMBL:X60316) AbaA gene ORFD (75 aa)%2C fasta scores%3B opt: 120 z-score: 206.5 E(): 0.00029%2C 43.8%25 identity in 48 aa overlap gene gene6691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6630 SCO6631 SCO6631 SC4G2.05 SC4G2.05 7358814 7359689 + hypothetical protein SC4G2.05%2C membrane protein%2C len: 291 aa%3B similar to TR:AAK74714 (EMBL:AE007366) Streptococcus pneumoniae conserved hypothetical protein SP0558%2C 271 aa%3B fasta scores: opt: 522 Z-score: 580.2 E(): 1.1e-24%3B 37.008%25 identity in 254 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene6692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6631 SCO6632 SCO6632 SC4G2.06 SC4G2.06 7359865 7360494 + hypothetical protein SC4G2.06%2C possible membrane protein%2C len: 149 aa%3B start uncertain gene gene6693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6632 SCO6633 SCO6633 SC4G2.07 SC4G2.07 7360499 7362409 + transcriptional regulator SC4G2.07%2C possible transcriptional regulator%2C len: 636 aa%3B similar to part of AFSR_STRCO regulatory protein AfsR (993 aa)%2C fasta scores%3B opt: 512 z-score: 733.8 E(): 0%2C 35.5%25 identity in 521 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop) gene gene6694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6633 SCO6634 SCO6634 SC4G2.08 SC4G2.08 7362458 7362646 + hypothetical protein SC4G2.08%2C unknown%2C len: 62 aa gene gene6695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6634 SCO6635 SCO6635 pglY pglY 7362943 7366827 + bacteriophage resistance gene pglY SC4G2.09%2C pglY%2C len: 1294 aa%3B 99.8%25 identical to S. coelicolor TR:Q53942 (EMBL:L37531) bacteriophage (phiC31) resistance gene pglY (1294 aa). Contains PS00017 ATP /GTP-binding site motif A (P-loop) gene gene6696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6635 SCO6636 SCO6636 pglZ pglZ 7366824 7369748 + bacteriophage resistance gene pglZ SC4G2.10%2C pglZ%2C len: 974 aa%3B 98.9%25 identical to S. coelicolor TR:Q53943 (EMBL:L37531) bacteriophage (phiC31) resistance gene pglZ (974 aa). gene gene6697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6636 SCO6637 SCO6637 SC4G2.11c SC4G2.11c 7369817 7370869 - hypothetical protein SC4G2.11c%2C unknown%2C len: 350 aa%3B identical to TR:Q53944 (EMBL:L37531) ORF3 downstream of PglZ (350 aa) gene gene6698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6637 SCO6638 SCO6638 SC4G2.12c SC4G2.12c 7370866 7372683 - hypothetical protein SC4G2.12c%2C unknown%2C len: 605 aa%3B identical to partial S. coelicolor sequence TR:Q53945 (EMBL:L37531) ORF4 downstream of PglZ (>302 aa) and weakly similar to Y686_METJA hypothetical protein MJ0686 (Methanococcus jannaschii) (580 aa)%2C fasta scores%3B opt: 260 z-score: 416.1 E(): 6.2e-16%2C 23.3%25 identity in 601 aa overlap. Contains TTA Leu codon%3B possible target for action of bldA gene gene6699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6638 SCO6639 SCO6639 SC4G2.13 SC4G2.13 7372859 7374208 + ATP/GTP binding protein SC4G2.13%2C probable ATP/GTP binding protein%2C len: 449 aa%3B similar to TR:O26411 (EMBL:AE000816) hypothetical protein MTH311 (Methanobacterium thermoautotrophicum) (411 aa)%2C fasta scores%3B opt: 596 z-score: 528.7 E(): 3.3e-22%2C 30.5%25 identity in 393 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) gene gene6700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6639 SCO6640 SCO6640 SC4G2.14 SC4G2.14 7374208 7376403 + ATP-dependent helicase SC4G2.14%2C probable ATP-dependent helicase%2C len: 731 aa%3B similar to many predicted helicases e.g. C-terminuis of LHR_ECOLI probable ATP-dependent helicase LHR (1538 aa)%2C fasta scores%3B opt: 332 z-score: 570.0 E(): 1.7e-24%2C 29.3%25 identity in 638 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop). Contains Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain gene gene6701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6640 SCO6641 SCO6641 SC4G2.15c SC4G2.15c 7376413 7377627 - hypothetical protein SC4G2.15c%2C unknown%2C len: 404 aa%3B N-terminus is similar to extreme C-terminus of TR:O26587 (EMBL:AE000832) DNA helicase related protein MTH487 (Methanobacterium thermoautotrophicum) (1157 aa)%2C fasta scores%3B opt: 467 z-score: 553.7 E(): 1.3e-23%2C 43.7%25 identity in 174 aa overlap gene gene6702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6641 SCO6642 SCO6642 SC4G2.16c SC4G2.16c 7377777 7378070 - hypothetical protein SC4G2.16c%2C questionable ORF%2C len: 97 aa gene gene6703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6642 SCO6643 SCO6643 SC4G2.17 SC4G2.17 7378334 7378888 + hypothetical protein SC4G2.17%2C unknown%2C len: 184 aa%3B some similarity to TR:O26772 (EMBL:AE000847) hypothetical protein MTH676 (Methanobacterium thermoautotrophicum) (205 aa)%2C fasta scores%3B opt: 260 z-score: 193.2 E(): 0.0016%2C 33.1%25 identity in 163 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family%2C score 38.50%2C E-value 1.5e-07 gene gene6704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6643 SCO6644 SCO6644 SC4G2.18 SC4G2.18 7378997 7380508 + solute-binding lipoprotein SC4G2.18%2C probable solute-binding lipoprotein%2C len: 503 aa%3B similar to many members of the bacterial extracellular solute-binding protein family 5YLIB_ECOLI binding protein YLIB precursor (512 aa)%2C fasta scores%3B opt: 364 z-score: 328.6 E(): 4.6e-11%2C 27.8%25 identity in 467 aa overlap. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and Pfam match to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5%2C score 36.60%2C E-value 2.2e-08 gene gene6705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6644 SCO6645 SCO6645 SC4G2.19 SC4G2.19 7380512 7382317 + transport system permease SC4G2.19%2C probable transport system permease%2C len: 601 aa%3B similar to many members of the oppBC family e.g. NIKB_ECOLI nickel transport system permease (314 aa)%2C fasta scores%3B opt: 405 z-score: 322.1 E(): 1.1e-10%2C 33.4%25 identity in 290 aa overlap gene gene6706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6645 SCO6646 SCO6646 SC4G2.20 SC4G2.20 7382319 7383629 + transport system permease SC4G2.20%2C probable transport system permease%2C len: 436 aa%3B similar to e.g. M. tuberculosis TR:O53861 (EMBL:AL022004) membrane transport protein MTV043.42 (419 aa)%2C fasta scores%3B opt: 771 z-score: 629.6 E(): 8e-28%2C 37.6%25 identity in 396 aa overlap gene gene6707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6646 SCO6647 SCO6647 SC4G2.21c SC4G2.21c 7383632 7384426 - hypothetical protein SC4G2.21c%2C possible integral membrane protein%2C len: 264 aa%3B similar to a hypothetical protein from Rhodobacter sphaeroides TR:O54078 (EMBL:AJ002398) (227 aa)%2C fasta scores%3B opt: 493 z-score: 616.8 E(): 4.1e-27%2C 43.6%25 identity in 220 aa overlap. Also very weak similarity to PGSA_PSEFL (CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) (195 aa) E:0.0018%2C 30.8%25 identity in 146 aa overlap. Contains PS00379 CDP-alcohol phosphatidyltransferases signature gene gene6708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6647 SCO6648 SCO6648 SC4G2.22 SC4G2.22 7384536 7384874 + hypothetical protein SC4G2.22%2C unknown%2C len: 112 aa gene gene6709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6648 SCO6649 SCO6649 SC4G2.23 SC4G2.23 7384871 7385545 + hypothetical protein SC4G2.23%2C unknown%2C len: 224 aa gene gene6710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6649 SCO6650 SCO6650 SC4G2.24 SC4G2.24 7385660 7386058 + hypothetical protein SC4G2.24%2C unknown%2C len: 132 aa gene gene6711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6650 SCO6651 SCO6651 SC4G2.25 SC4G2.25 7386055 7387293 + glycosyl transferase SC5A7.01%2C possible glycosyl transferase%2C partial CDS%2C len: >368 aa%3B similar to several hypothetical proteins e.g. YV12_MYCTU MTCY20G9.12 (480 aa)%2C fasta sores%3B opt: 237 z-score: 252.3 E(): 8.1e-07%2C 29.9%25 identity in 278 aa overlap%2C and to WCAL_ECOLI colanic acid biosynthesis glycosyl transferase (406 aa)%2C fasta sores%3B opt: 187 z-score: 194.8 E(): 0.0013%2C 27.8%25 identity in 237 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1%2C Glycosyl transferases group 1%2C score 52.90%2C E-value 5.5e-14~SC4G2.25%2C possible glycosyl transferase%2C partial CDS%2C len: >78 aa%3B overlaps and extends glycosyl transferase SC5A7.01 gene gene6712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6651 SCO6652 SCO6652 SC5A7.02 SC5A7.02 7387290 7388675 + hypothetical protein SC5A7.02%2C unknown%2C len: 461 aa%3B contains 6 degenerate repeats of P(AT)ESAVPA gene gene6713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6652 SCO6653 SCO6653 SC5A7.03 SC5A7.03 7388672 7389874 + hypothetical protein SC5A7.03%2C probable integral membrane protein%2C len: 400 aa. Note 63 aa overlap with convergent downstream ORF. Contains possible hydrophobic membrane spanning regions gene gene6714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6653 SCO6654 SCO6654 SC5A7.04c SC5A7.04c 7389679 7390500 - hypothetical protein SC5A7.04c%2C unknown%2C len: 273 aa%3B some similarity to hypothetical proteins and to Pseudomonas TR:Q52548 (EMBL:D45424) creatinine amidohydrolase (259 aa)%2C fasta sores%3B opt: 193 z-score: 273.1 E(): 5.6e-08 27.3%25 identity in 238 aa overlap. Note 63 aa overlap with convergent downstream ORF gene gene6715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6654 SCO6655 SCO6655 ribA2 ribA2 7390536 7391201 + GTP cyclohydrolase II SC5A7.05%2C ribA2%2C GTP cyclohydrolase II%2C len: 221 aa%3B highly similar to the C-terminus of many RibA genes where the GTP cyclohydrolase activity is%2C e.g. GCH2_BACSU GTP cyclohydrolase II (EC 3.5.4.25) (398 aa)%2C fasta sores%3B opt: 656 z-score: 960.9 E(): 0%2C 53.1%25 identity in 196 aa overlap and to SW:GCH2_ARATH (EMBL:D45165) Arabidopsis thaliana GTP cyclohydrolase II (EC 3.5.4.25) 245 aa%3B fasta scores: opt: 656 Z-score: 760.1 E(): 1.1e-34%3B 51.832%25 identity in 191 aa overlap gene gene6716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6655 SCO6656 SCO6656 SC5A7.06c SC5A7.06c 7391232 7392461 - hypothetical protein SC5A7.06c%2C unknown%2C len: 409 aa%3B similar to several hypothetical protein e.g. Y07V_MYCTU MTCY02B10.31C (377 aa)%2C fasta sores%3B opt: 675 z-score: 725.7 E(): 3.5e-33%2C 40.9%25 identity in 340 aa overlap%2C and more distantly to several penicillin binding proteins e.g. PBPE_BACSU penicillin-binding protein 4* (451 aa)%2C fasta sores%3B opt: 148 z-score: 268.0 E(): 1.1e-07%2C 24.9%25 identity in 350 aa overlap gene gene6717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6656 SCO6657 SCO6657 SC5A7.07c SC5A7.07c 7392553 7394136 - hypothetical protein SC5A7.07c%2C membrane protein%2C len: 527 aa%3B similar to two consecutive genes downstream of HISX_STRCO S. colelicolor histidinol dehydrogenase%3B TR:Q53931 and TR:Q53930%2C fasta scores%3B E(): 1.4e-07%2C 34.3%25 identity in 213 aa overlap and E(): 1.1e-06%2C 32.3%25 identity in 223 aa overlap. Contains possible hydrophobic membrane spanning region at C-terminal domain gene gene6718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6657 SCO6658 SCO6658 SC5A7.08c SC5A7.08c 7394148 7395029 - 6-phosphogluconate dehydrogenase similar to full-length Gnd%2C these proteins seems to have a truncated C-terminal 6PGD domainin%3B in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate gene gene6719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6658 SCO6659 SCO6659 pgi pgi 7395031 7396683 - glucose-6-phosphate isomerase functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis%3B catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate%3B member of PGI family gene gene6720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6659 SCO6660 SCO6660 SC5A7.10c SC5A7.10c 7396676 7397611 - hypothetical protein SC5A7.10c%2C unknown%2C len: 311 aa%3B similar to a hypothetical protein from M. tuberculosis TR:O06813 (EMBL:Z95844) MTCY493.08 (303 aa)%2C fasta scores%3B opt: 847 z-score: 1016.2 E(): 0%2C 47.7%25 identity in 304 aa overlap. Also some similarity to OPCA_SYNP7 oxpp cycle protein OpCA (which may be involved in functional assembly of glucose 6-phosphate dehydrogenase) (444 aa)%2C fasta scores%3B opt: 149 z-score: 218.9 E(): 5.9e-05%2C 32.4%25 identity in 142 aa overlap. Note that both of these proteins are downstream of glucose-6-phosphate dehydrogenase genes gene gene6721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6660 SCO6661 SCO6661 SC5A7.11c SC5A7.11c 7397608 7399386 - glucose-6-phosphate 1-dehydrogenase catalyzes the formation of D-glucono-1%2C5-lactone 6-phosphate from D-glucose 6-phosphate gene gene6722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6661 SCO6662 SCO6662 tal1 tal1 7399383 7400528 - transaldolase catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate gene gene6723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6662 SCO6663 SCO6663 tktB tktB 7400592 7402688 - transketolase catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate%3B can transfer ketol groups between several groups%3B in Escherichia coli there are two tkt genes%2C tktA expressed during exponential growth and the tktB during stationary phase gene gene6724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6663 SCO6664 SCO6664 SC5A7.14 SC5A7.14 7402846 7403751 + transcriptional regulator SC5A7.14%2C probable transcriptional regulator%2C len: 301 aa%3B some similarity to many members of the araC family%2C e.g. MMSR_PSEAE MmsAB operon regulatory protein (307 aa)%2C fasta scores%3B opt: 113 z-score: 251.4 E(): 9.2e-07%2C 25.4%25 identity in 303 aa overlap. Contains probable helix-turn-helix motif from aa 216-237 (Score 1252%2C +3.45 SD) and Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C score 63.30%2C E-value 5.3e-15 gene gene6725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6664 SCO6665 SCO6665 SC5A7.15c SC5A7.15c 7403831 7405231 - glucosidase SC5A7.15c%2C probable glucosidase%2C len: 466 aa%3B similar to e.g. TR:G2981143 (EMBL:AF052745) beta-1%2C3-glucanase II from Oerskovia xanthineolytica (435 aa)%2C fasta scores%3B opt: 313 z-score: 413.3 E(): 8.7e-16%2C 37.0%25 identity in 435 aa overlapand XYND_BACPO endo-1%2C4-beta-xylanase D precursor (Bacillus polymyxa) (635 aa)%2C fasta scores%3B opt: 339 z-score: 315.2 E(): 2.6e-10%2C 27.5%25 identity in 447 aa overlap gene gene6726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6665 SCO6666 SCO6666 SC5A7.16c SC5A7.16c 7405534 7407651 - hypothetical protein SC5A7.16c%2C probable integral membrane protein len: 705 aa%3B similar to many hypothetical membrane proteins e.g. M. tuberculosis TR:E1299723 (EMBL:AL021928) MMPL3 (944 aa)%2C fasta scores%3B opt: 482 z-score: 907.8 E(): 0%2C 33.3%25 identity in 744 aa overlap gene gene6727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6666 SCO6667 SCO6667 SC5A7.17c SC5A7.17c 7407798 7408466 - two-component regulator SC5A7.17c%2C probable two-component regulator%2C len: 222 aa%3B highly similar to many e.g. DEGU_BACSU transcriptional regulatory protein DegU (229 aa)%2C fasta scores%3B opt: 561 z-score: 630.7 E(): 7e-28%2C 44.0%25 identity in 225 aa overlap. Contains PS00622 Bacterial regulatory proteins%2C luxR family signature%2C probable helix-turn-helix motif from aa 173 to 194 (Score 1001%2C +2.60 SD) and Pfam matches to entry PF00072 response_reg%2C Response regulator receiver domain%2C score 124.10%2C E-value 2.7e-33 and entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C score 86.30%2C E-value 6.1e-22 gene gene6728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6667 SCO6668 SCO6668 SC5A7.18c SC5A7.18c 7408463 7409680 - two-component sensor SC5A7.18c%2C probable two-component sensor%2C len: 405 aa%3B similar in C-terminus to many e.g. NARQ_ECOLI nitrate /nitrite sensor protein narQ (566 aa)%2C fasta scores%3B opt: 230 z-score: 252.5 E(): 7.9e-07%2C 30.7%25 identity in 202 aa overlap. N-terminus contains six probable trans-membrane domains. Contains probable coiled-coil from 168 to 197 gene gene6729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6668 SCO6669 SCO6669 SC5A7.19c SC5A7.19c 7409712 7410506 - transcriptional regulator SC5A7.19c%2C probable transcriptional regulator%2C len: 264 aa%3B similar to members of the iclR family e.g. GYLR_STRCO glycerol operon regulatory protein (254 aa)%2C fasta scores%3B opt: 277 z-score: 318.0 E(): 1.8e-10%2C 31.4%25 identity in 245 aa overlap. Contains probable helix-turn-helix motif from aa 28-49 (Score 1240%2C +3.41 SD) gene gene6730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6669 SCO6670 SCO6670 SC5A7.20 SC5A7.20 7410645 7411970 + glucosidase SC5A7.20%2C probable glucosidase%2C len: 441 aa%3B similar to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa)%2C fasta scores%3B opt: 537 z-score: 628.7 E(): 8.8e-28%2C 31.8%25 identity in 456 aa overlap gene gene6731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6670 SCO6671 SCO6671 SC5A7.21c SC5A7.21c 7411963 7413129 - hypothetical protein SC5A7.21c%2C unknown%2C len: 388 aa%3B Similar to TR:Q9RSB2 (EMBL:AE002054) conserved hypothetical protein from Deinococcus radiodurans (338 aa) fasta scores%3B opt: 415%2C Z-score: 392.3%2C E(): 3.2e-14%2C 31.333%25 identity (32.639%25 ungapped) in 300 aa overlap. Contains nine degenerate PA repeats at C-terminus gene gene6732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6671 SCO6672 SCO6672 SC5A7.22 SC5A7.22 7413412 7414299 + hypothetical protein SC5A7.22%2C unknown%2C len: 295 aa%3B similar to a hypothetical protein from M. tuberculosis TR:O33337 (EMBL:AL008967) MTV002.60C (324 aa)%2C fasta scores%3B opt: 1202 z-score: 1507.9 E(): 0%2C 57.2%25 identity in 285 aa overlap gene gene6733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6672 SCO6673 SCO6673 SC5A7.23 SC5A7.23 7414296 7414976 + hypothetical protein SC5A7.23%2C unknown%2C len: 226 aa%3B similar to hypothetical proteins from Streptomyces and M. tuberculosis e.g. S. coelicolor TR:O24813 (EMBL:AB007189) (208 aa)%2C fasta scores%3B opt: 674 z-score: 960.0 E(): 0%2C 49.1%25 identity in 214 aa overlap gene gene6734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6673 SCO6674 SCO6674 SC5A7.24c SC5A7.24c 7414995 7415231 - hypothetical protein SC5A7.24c%2C unknown%2C len: 78 aa gene gene6735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6674 SCO6675 SCO6675 SC5A7.25c SC5A7.25c 7415327 7415983 - DNA-binding protein SC5A7.25c%2C possible DNA-binding protein%2C len: 218 aa. Contains probable helix-turn-helix motif from aa 92-113 (Score 1665%2C +4.86 SD) gene gene6736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6675 SCO6676 SCO6676 SC5A7.26 SC5A7.26 7416168 7416875 + hypothetical protein SC5A7.26%2C unknown%2C len: 235 aa gene gene6737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6676 SCO6677 SCO6677 SC5A7.27c SC5A7.27c 7416767 7417309 - ABC transporter ATP-binding protein SC5A7.27c%2C probable ABC transporter ATP-binding protein%2C len: 180 aa%3B similar to part of many e.g. taurine transport atp-binding protein tauB (255 aa)%2C fasta scores%3B opt: 309 z-score: 436.0 E(): 4.9e-17%2C 43.6%25 identity in 117 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 31.20%2C E-value 1.9e-09. Has large overlap with convergent downstream gene%3B database similarities do not extend into the overlap. The sequence of the cosmid has been checked%2C and is correct gene gene6738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6677 SCO6678 SCO6678 SC5A7.28c SC5A7.28c 7417332 7418273 - iron-sulfur oxidoreductase subunit beta SC5A7.28c%2C probable iron-sulfur oxidoreductase beta subunit%2C len: 313 aa%3B similar to many e.g. POBB_PSEPS phenoxybenzoate dioxygenase beta subunit (Pseudomonas pseudoalcaligenes) (319 aa)%2C fasta scores%3B opt: 824 z-score: 993.1 E(): 0%2C 45.9%25 identity in 303 aa overlap. C-terminus is a 2Fe-2S ferredoxin domain similar to e.g. FERV_ANAVA ferredoxin%2C vegetative (Anabaena variabilis) (98 aa)%2C fasta scores%3B opt: 187 z-score: 222.4 E(): 3.8e-05%2C 38.2%25 identity in 68 aa overlap. Contains PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature and Pfam match to entry PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains%2C score 35.50%2C E-value 1.2e-06 gene gene6739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6678 SCO6679 SCO6679 SC5A7.29c SC5A7.29c 7418270 7418440 - hypothetical protein SC5A7.29c%2C unknown%2C len: 56 aa gene gene6740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6679 SCO6680 SCO6680 SC5A7.30c SC5A7.30c 7418437 7419516 - oxidoreductase subunit alpha SC5A7.30c%2C probable oxidoreductase alpha subunit%2C len: 359 aa%3B similar to many e.g. VANA_PSES9 vanillate demethylase (monooxygenase) (329 aa)%2C fasta scores%3B opt: 636 z-score: 695.7 E(): 1.7e-31%2C 34.6%25 identity in 338 aa overlap gene gene6741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6680 SCO6681 SCO6681 SC5A7.31 SC5A7.31 7419664 7422456 + Ser/Thr protein kinase SC5A7.31%2C unknown%2C len 930 aa%3B some similarity to several e.g. PKN2_MYXXA serine-threonine-protein kinase Pkn2 (Myxococcus xanthus) (830 aa)%2C Smith-Waterman scores%3B E: 1.5e-06%2C 23%25 identity in 829 bp overlap. Also has short segment of similarity to the active site regions of several Serine-Threonine protein kinases e.g. PKAA_STRCO P54739 serine-threonine protein kinase pkaA (533 aa)%2C blastp scores%3B Expect%3D 3.7e-05%2C 39%25 identity in 27 aa overlap. Contains possible transmembrane anchor and six degenerate repeats of the sequence VDETTR gene gene6742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6681 SCO6682 SCO6682 SC5A7.32 SC5A7.32 7422494 7422622 + hypothetical protein SC5A7.32%2C unknown%2C len: 42 aa%3B similar to CDS upstream of S. griseus RamA TR:Q07642 (EMBL:D13614) (43 aa)%2C fasta scores%3B opt: 154 z-score: 293.0 E(): 4.4e-09%2C 53.7%25 identity in 41 aa overlap gene gene6743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6682 SCO6683 SCO6683 ramA ramA 7422658 7424568 + ABC transporter ATP-binding protein SC5A7.33%2C ramA%2C probable ABC transporter%2C len: 636 aa%3B N-terminus contains transmembrane domain%2C C-terminus contains ATP-binding domain. Almost identical to TR:Q53818 (EMBL:U03771) potential ATP-binding membrane transport protein RamA (636 aa)(99.8%25 identity in 636 aa overlap)Y08A_MYCTU hypothetical ABC transporter ATP-binding protein MTCY50.10 (631 aa)%2C fasta scores%3B opt: 556 z-score: 414.6 E(): 7.4e-16%2C 28.1%25 identity in 626 aa overlap. Contains sixteen degenerate GA repeats at C-terminus%2C PS00017 ATP /GTP-binding match to entry PF00005 ABC_tran%2C ABC transporters%2C score 139.50%2C E-value 6e-38. Some similarity to RamB (E(): 3.7e-05%2C 32.7%25 identity in 627 aa overlap) gene gene6744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6683 SCO6684 SCO6684 ramB ramB 7424565 7426391 + ABC transporter ATP-binding protein SC5A7.34%2C ramB%2C probable ABC transporter%2C len: 608 aa%3B N-terminus contains transmembrane domain%2C C-terminus contains ATP-binding domain. IdenticalTR:Q53819 (EMBL:U03771) potential ATP-binding membrane protein RamB (608 aa) and similar tyo many e.g. Y07D_MYCTU hypothetical ABC transporter ATP-binding protein MTCY02B10.13 (579 aa)%2C fasta scores%3B opt: 456 z-score: 443.0 E(): 1.9e-17%2C 31.8%25 identity in 614 aa overlap. Contains sixteen degenerate PE repeats between the N- andC-terminal domains. Also contains PS00017 ATP /GTP-binding site motif A (P-loop)%2C PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran%2C ABC transporters%2C score 157.10%2C E-value 3e-43. Some similarity to RamA (E(): 2.7e-05%2C 33.4%25 identity in 628 aa overlap) gene gene6745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6684 SCO6685 SCO6685 ramR ramR 7426396 7427004 - two-component system response regulator SC5A7.35c%2C ramR%2C two-component system response regulator%2C len: >41 aa. Identical to TR:Q53820 (EMBL:U03771) potential response regulator for aerial mycelium production RamR (202 aa)%2C and similar to many e.g. Streptomyces peucetius TR:Q54821 (EMBL:L37338) daunorubicin biosynthesis regulatory protein dnrN (202 aa)%2C fasta scores%3B opt: 173 z-score: 382.4 E(): 4.6e-14%2C 65.0%25 identity in 40 aa overlap~SC6G3.01c%2C ramR%2C probable two-component system response regulator%2C partial CDS%2C len: >201 aa%3B previously sequenced as TR:Q53820 (EMBL:U03771)%2C RamR%2C potential response regulator for aerial mycelium production. Similar to many two-component system transcriptional regulators e.g. TR:Q07640 (EMBL:AB006206)%2C AfmR%2C Streptomyces griseus transcriptional regulator involved in aerial mycelium formation (210 aa)%2C fasta scores%3B opt: 466 z-score: 545.2 E(): 4.9e-23%2C 42.6%25 identity in 202 aa overlap. An alternative start codon is present at codon 4. Contains probable helix-turn-helix motif at aa 158-179 (Score 1876%2C +5.58 SD). Contains Pfam match to PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family gene gene6746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6685 SCO6686 SCO6686 SC6G3.02 SC6G3.02 7427533 7428411 + hypothetical protein SC6G3.02%2C hypothetical protein%2C len: 292 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Similar to TR:Q9RJY9 (EMBL:AL133210) Streptomyces coelicolor hypothetical protein SCF37.12%2C 284 aa%3B fasta scores: opt: 864 Z-score: 995.3 E(): 8.3e-48%3B 47.902%25 identity in 286 aa overlap gene gene6747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6686 SCO6687 SCO6687 SC6G3.03 SC6G3.03 7428452 7433488 + DNA-binding protein SC6G3.03%2C hypothetical protein%2C len: 1678 aa%3B unknown function%2C probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition. Contains probable helix-turn-helix motif at aa 1209-1230 (Score 1004%2C +2.61 SD). Similar to TR:Q9RJY8 (EMBL:AL133210) Streptomyces coelicolor hypothetical protein SCF37.13%2C 1726 aa%3B fasta scores: opt: 690 Z-score: 706.5 E(): 1e-31%3B 35.556%25 identity in 1800 aa overlap gene gene6748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6687 SCO6688 SCO6688 SC6G3.04 SC6G3.04 7433569 7437084 + hypothetical protein SC6G3.04%2C hypothetical protein%2C len: 1171 aa%3B unknown function%2C C-terminal 380 aa (approx.) similar to SW:YEHP_ECOLI (EMBL:AE000301)%2C yehP%2C Escherichia coli hypothetical protein (378 aa)%2C fasta scores%3B opt: 610 z-score: 603.7 E(): 2.7e-26%2C 34.5%25 identity in 394 aa overlap and N-terminal 750 aa (approx.) similar to SW:YEHM_ECOLI (EMBL:AE000301)%2C yehM%2C Escherichia coli hypothetical protein (759 aa) (25.4%25 identity in 796 aa overlap). The hypothetical proteins yehMP are adjacent on the E.coli chromosome. Part of this probable CDS (aa 530-830 approx.) is also similar to TR:Q54218 (EMBL:X77865) Streptomyces griseus chain length determination factor (412 aa) (31.5%25 identity in 340 aa overlap) gene gene6749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6688 SCO6689 SCO6689 SC6G3.05 SC6G3.05 7437081 7438847 + hypothetical protein SC6G3.05%2C hypothetical protein%2C len: 588 aa%3B similar to TR:Q9RJY5 (EMBL:AL133210) Streptomyces coelicolor hypothetical protein SCF37.16%2C 667 aa%3B fasta scores: opt: 633 Z-score: 604.5 E(): 4.9e-26%3B 40.441%25 identity in 680 aa overlap. Probable CDS suggested by GC frameplot%2C positional base preference and amino acid composition gene gene6750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6689 SCO6690 SCO6690 SC6G3.06c SC6G3.06c 7438926 7440206 - transmembrane transport protein SC6G3.06c%2C probable transmembrane transport protein%2C len: 426 aa%3B similar to many transporters e.g. SW:KGTP_ECOLI (EMBL:X53027)%2C kgtP%2C Escherichia coli alpha-ketoglutarate permease (432 aa)%2C fasta scores%3B opt: 1088 z-score: 1249.1 E(): 0%2C 41.1%25 identity in 419 aa overlap. Highly similar to TR:Q03095 (EMBL:M64783) Streptomyces hygroscopicus bialaphos transport protein (447 aa) (57.3%25 identity in 412 aa overlap). Similar to TR:O86563 (EMBL:AL031184) S.coelicolor probable transmembrane transport protein (472 aa) (31.7%25 identity in 436 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Contains Pfam match to PF00083 sugar_tr%2C Sugar (and other) transporter%2C PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2 gene gene6751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6690 SCO6691 SCO6691 SC4C6.01 SC4C6.01 7440399 7442462 + phospholipase C SC4C6.01%2C probable phospholipase C%2C partial CDS%2C len: >501 aa%3B similar to e.g. SW:PHLN_PSEAE (EMBL:M59304)%2C plcN%2C Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa)%2C fasta scores%3B opt: 1073 z-score: 1149.1 E(): 0%2C 44.7%25 identity in 524 aa overlap~SC6G3.07%2C probable phospholipase C%2C partial CDS%2C len: >221 aa%3B similar to e.g. SW:PHLN_PSEAE (EMBL:M59304)%2C plcN%2C Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa)%2C fasta scores%3B opt: 853 z-score: 1021.1 E(): 0%2C 51.3%25 identity in 232 aa overlap. Continues in cosmid 4C6 (EMBL:AL079355) as SC4C6.01 gene gene6752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6691 SCO6692 SCO6692 SC4C6.02c SC4C6.02c 7442516 7443469 - hypothetical protein SC4C6.02c%2C probable integral membrane protein%2C len: 317 aa%3B similar to TR:O86668 (EMBL:AL031182) S.coelicolor probable integral membrane protein (299 aa)%2C fasta scores%3B opt: 288 z-score: 279.1 E(): 3.2e-08%2C 32.8%25 identity in 299 aa overlap and to TR:O33234 (EMBL:Z98209) Mycobacterium tuberculosis hypothetical protein (301 aa) (28.8%25 identity in 299 aa overlap). Contains hydrophobic%2C possible membrane-spanning regions. Weakly similar to TR:O86668 (EMBL:AL031182) S.coelicolor integral membrane protein (299 aa) (32.8%25 identity in 299 aa overlap) gene gene6753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6692 SCO6693 SCO6693 SC4C6.03c SC4C6.03c 7443466 7444281 - hypothetical protein SC4C6.03c%2C possible membrane protein%2C len: 271 aa%3B similar to TR:Q9KZ06 (EMBL:AL355752) Streptomyces coelicolor integral membrane protein SC10B7.28%2C 287 aa%3B fasta scores: opt: 489 Z-score: 561.8 E(): 1.2e-23%3B 36.471%25 identity in 255 aa overlap. Unknown function%2C probable CDS suggested by positional base preference%2C GC frame plot and amino acid composition. Contains hydrophobic%2C possible membrane-spanning regions gene gene6754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6693 SCO6694 SCO6694 SC4C6.04 SC4C6.04 7444457 7445071 + transcriptional regulator SC4C6.04%2C possible transcriptional regulator%2C len: 204 aa%3B similar to many e.g. TR:P72185 (EMBL:U51164)%2C HemR%2C Propionibacterium freudenreichii repressor protein from hemYHBXRL gene cluster (involved in the biosynthetic pathway from glutamate to protoheme) (259 aa)%2C fasta scores%3B opt: 205 z-score: 251.7 E(): 1.1e-06%2C 28.5%25 identity in 200 aa overlap. Contains probable helix-turn-helix motif at aa 45-66 (Score 1187%2C +3.23 SD). Weakly similar to others from S.coelicolor e.g. TR:O69987 (EMBL:AL022268) S.coelicolor probable transcriptional regulator%2C partial CDS (>111 aa) (42.4%25 identity in 85 aa overlap) is similar to the N-terminal half gene gene6755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6694 SCO6695 SCO6695 SC4C6.05c SC4C6.05c 7445240 7446283 - hypothetical protein SC4C6.05c%2C possible membrane protein%2C len: 347 aa%3B similar to TR:O88067 (EMBL:AL031541) S.coelicolor possible membrane protein (319 aa)%2C fasta scores%3B opt: 474 z-score: 403.9 E(): 3.6e-15%2C 37.9%25 identity in 354 aa overlap. Contains 4x PPXQ repeats starting at aa 46. Contains a hydrophobic%2C possible membrane-spanning region. Similar to TR:O88067 (EMBL:AL031541) S.coelicolor possible membrane protein (319 aa) (37.9%25 identity in 354 aa overlap). Contains possible hydrophobic membrane spanning region gene gene6756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6695 SCO6696 SCO6696 SC4C6.06 SC4C6.06 7446559 7449240 + regulatory protein SC4C6.06%2C possible regulatory protein%2C len: 893 aa%3B similar to many regulators e.g. TR:Q55103 (EMBL:D13457) Streptomyces sp. ORF upstream of the cholesterol oxidase-cytochrome P450 operon (642 aa) fasta scores%3B opt: 347 z-score: 383.0 E(): 5.2e-14%2C 31.7%25 identity in 599 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Similar to (EMBL:AL035569) SC8D9.18 possible regulatory protein (1091 aa) (28.1%25 identity in 945 aa overlap) gene gene6757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6696 SCO6697 SCO6697 pcaL pcaL 7449267 7450394 - 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase SC4C6.07c%2C pcaL%2C probable 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase%2C len: 375 aa%3B similar to TR:O67982 (EMBL:AF003947)%2C pcaL%2C Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (400 aa)%2C fasta scores%3B opt: 401 z-score: 464.7 E(): 1.5e-18%2C 46.3%25 identity in 387 aa overlap the first approx. 260 aa is similar to SW:ELH2_ACICA (EMBL:AF009224)%2C catD%2C Acinetobacter calcoaceticus 3-oxoadipate enol-lactonase II (266 aa) (35.1%25 identity in 248 aa overlap) while the remainder is similar to SW:DC4C_ACICA (EMBL:L05770)%2C pcaC%2C 4-carboxymuconolactone decarboxylase. Highly similar to TR:O86608 (EMBL:AL031155) S.coelicolor probable 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (449 aa) (43.3%25 identity in 439 aa overlap) which contains an approx. 70 residue insertion between the two domains of homology to the Acinetobacter enzymes. An alternative start codon is present at codon 4. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene6758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6697 SCO6698 SCO6698 pcaB pcaB 7450391 7451755 - 3-carboxy-cis%2Ccis-muconate cycloisomerase SC4C6.08c%2C pcaB%2C probable 3-carboxy-cis%2Ccis-muconate cycloisomerase%2C len: 454 aa%3B similar to e.g. SW:PCAB_BRAJA (EMBL:Y10223)%2C pcaB%2C 3-carboxy-cis%2Ccis-muconate cycloisomerase (451 aa)%2C fasta scores%3B opt: 996 z-score: 1027.1 E(): 0%2C 43.3%25 identity in 448 aa overlap. Contains Pfam match to entry PF00206 lyase_1%2C Lyase and PS00163 Fumarate lyases signature gene gene6759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6698 SCO6699 SCO6699 pcaG pcaG 7451752 7452357 - protocatechuate 3%2C4-dioxygenase subunit alpha SC4C6.09c%2C pcaG%2C protocatechuate 3%2C4-dioxygenase alpha subunit%2C len: 201 aa%3B highly similar to pcaG (EMBL:AF109386) Streptomyces sp. 2065 protocatechuate 3%2C4-dioxygenase alpha subunit (201 aa)%2C fasta scores%3B opt: 1144 z-score: 1272.2 E(): 0%2C 80.1%25 identity in 201 aa overlap gene gene6760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6699 SCO6700 SCO6700 pcaH pcaH 7452364 7453137 - protocatechuate 3%2C4-dioxygenase subunit beta SC4C6.10c%2C pcaH%2C protocatechuate 3%2C4-dioxygenase beta subunit%2C len: 257 aa%3B highly similar to pcaH (EMBL:AF109386) Streptomyces sp. 2065 protocatechuate 3%2C4-dioxygenase beta subunit (257 aa)%2C fasta scores%3B opt: 1686 z-score: 1951.2 E(): 0 91.1%25 identity in 257 aa overlap. Contains Pfam match to entry PF00775 Dioxygenase%2C Dioxygenase and PS00083 Intradiol ring-cleavage dioxygenases signature gene gene6761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6700 SCO6701 SCO6701 pcaF pcaF 7453156 7454358 - beta-ketoadipyl-CoA thiolase SC4C6.11c%2C pcaF%2C beta-ketoadipyl-CoA thiolase%2C len: 400 aa%3B highly similar to pcaF (EMBL:AF117893) Streptomyces sp. 2065 beta-ketoadipyl-CoA thiolase (400 aa)%2C fasta scores%3B opt: 2314 z-score: 2497.6 E(): 0%2C 87.4%25 identity in 397 aa overlap. Highly similar others from S.coelicolor e.g. (EMBL:AL049587)%2C SC5F2A.14%2C S.coelicolor probable thiolase (404 aa) (40.2%25 identity in 423 aa overlap). Contains Pfam match to entry PF00108 thiolase%2C Thiolase%2C PS00099 Thiolases active site%2C PS00098 Thiolases acyl-enzyme intermediate signature and PS00737 Thiolases signature 2 gene gene6762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6701 SCO6702 SCO6702 pcaJ pcaJ 7454355 7455008 - 3-oxoadipate CoA-transferase subunit B SC4C6.12c%2C pcaJ%2C probable 3-oxoadipate CoA-transferase subunit B%2C len: 217 aa%3B highly similar to many CoA transferases e.g. SW:PCAJ_PSEPU (EMBL:M88763)%2C PcaJ%2C Pseudomonas putida 3-oxoadipate CoA-transferase subunit B (212 aa)%2C fasta scores%3B opt: 684 z-score: 774.2 E(): 0%2C 52.9%25 identity in 206 aa overlap. Highly similar to SW:SCOB_MYCTU (EMBL:Z95556)%2C ScoB%2C Mycobacterium tuberculosis probable succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (218 aa) (73.9%25 identity in 207 aa overlap). Contains Pfam match to entry PF01144 CoA_trans%2C Coenzyme A transferase gene gene6763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6702 SCO6703 SCO6703 pcaI pcaI 7455008 7455790 - 3-oxoadipate CoA-transferase subunit A SC4C6.13c%2C pcaI%2C probable 3-oxoadipate CoA-transferase subunit A%2C len: 260 aa%3B highly similar to many CoA transferases e.g. SW:PCAI_PSEPU (EMBL:M88763)%2C pcaI%2C Pseudomonas putida 3-oxoadipate CoA-transferase subunit A (231 aa)%2C fasta scores%3B opt: 337 z-score: 379.8 E(): 8e-14%2C 42.6%25 identity in 242 aa overlap. Highly similar to SW:SCOA_MYCTU (EMBL:Z95556)%2C scoA%2C Mycobacterium tuberculosis probable succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (248 aa) (69.9%25 identity in 249 aa overlap). Contains Pfam match to entry PF01144 CoA_trans%2C Coenzyme A transferase and PS01273 CoA transferases signature 1 gene gene6764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6703 SCO6704 SCO6704 SC4C6.14 SC4C6.14 7456000 7456464 + transcriptional regulator SC4C6.14%2C possible transcriptional regulator%2C len: 154 aa%3B similar to e.g. SW:MEXR_PSEAE (EMBL:U23763)%2C MexR%2C Pseudomonas aeruginosa multidrug resistance operon repressor (147 aa)%2C fasta scores%3B opt: 180 z-score: 234.3 E(): 1e-05%2C 30.7%25 identity in 114 aa overlap. C-terminal half shows highest similarity with other transcriptional regulators. C-terminal half similar to others from S. coelicolor e.g. TR:O86554 (EMBL:AL031350) S. coelicolor hypothetical protein (143 aa) (31.6%25 identity in 98 aa overlap). Could be a divergently-transcribed transcriptional regulator for the pca operon upstream of this CDS (very hypothetical). Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene6765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6704 SCO6705 SCO6705 SC4C6.15c SC4C6.15c 7456480 7457457 - hypothetical protein SC4C6.15c%2C probable hypothetical protein%2C len: 325 aa%3B similar to TR:O30567 (EMBL:AF011544)%2C yecC%2C Bacillus subtilis hypothetical protein (331 aa)%2C fasta scores%3B opt: 278 z-score: 312.3 E(): 4.6e-10%2C 25.9%25 identity in 305 aa overlap. Also similar to yerB%2C which is identical to yecC. Contains a probable N-terminal signal sequence gene gene6766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6705 SCO6706 SCO6706 SC4C6.16 SC4C6.16 7457668 7458858 + glutathione-dependent aldehyde dehydrogenase SC4C6.16%2C probable glutathione-dependent aldehyde dehydrogenase%2C len: 396 aa%3B similar to many e.g. SW:FADH_METMR (EMBL:L33464)%2C fdh%2C Methylobacter marinus glutathione-dependent formaldehyde dehydrogenase (424 aa)%2C fasta scores%3B opt: 1126 z-score: 1211.8 E(): 0%2C 44.1%25 identity in 406 aa overlap. Similar to (EMBL:AL049485)%2C SC6A5.31c%2C S.coelicolor probable zinc-binding alcohol dehydrogenase (363 aa) (31.0%25 identity in 316 aa overlap). Contains Pfam match to entry PF00107%2C adh_zinc%2C Zinc-binding dehydrogenases and PS00059 Zinc-containing alcohol dehydrogenases signature gene gene6767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6706 SCO6707 SCO6707 ligC ligC 7458874 7459941 - ATP-dependent DNA ligase catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA%3B in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth gene gene6768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6707 SCO6708 SCO6708 SC4C6.18 SC4C6.18 7460154 7460492 + hypothetical protein SC4C6.18%2C possible membrane protein%2C len: 112 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame plot and amino acid composition. Contains hydrophobic%2C possible membrane-spanning regions gene gene6769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6708 SCO6709 SCO6709 SC4C6.19 SC4C6.19 7460584 7461609 + hypothetical protein SC4C6.19%2C conserved hypothetical protein%2C len: 341 aa%3B similar to hypothetical proteins from Mycobacterium tuberculosis%2C Mycobacterium leprae and Bacillus subtilis e.g. TR:O69697 (EMBL:AL02212) Mycobacterium tuberculosis hypothetical protein (346 aa)%2C fasta scores%3B opt: 1313 z-score: 1504.6 E(): 0%2C 59.2%25 identity in 336 aa overlap. Similarity is confined to the N-terminal end in cases where the similar protein is longer then this one e.g. TR:O05865 (EMBL:Z95209) Mycobacterium tuberculosis hypothetical protein (759 aa) (28.3%25 identity in 336 aa overlap). Also similar to SC1E6.07 (EMBL:AL033505) S.coelicolor hypothetical protein (319 aa) (35.8%25 identity in 288 aa overlap) gene gene6770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6709 SCO6710 SCO6710 SC4C6.20c SC4C6.20c 7461626 7463815 - glycosyl hydrolase gene gene6771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6710 SCO6711 SCO6711 SC4C6.21c SC4C6.21c 7463830 7466175 - hypothetical protein SC4C6.21c%2C hypothetical protein%2C len: 781 aa%3B unknown function%2C C-terminal half similar to N-terminal region of TR:O69947 (EMBL:AL023862) S.coelicolor hypothetical protein (1238 aa)%2C fasta scores%3B opt: 818 z-score: 850.9 E(): 0%2C 38.5%25 identity in 535 aa overlap. The downstream ORF SC4C6.20c has weak similarity to the C-terminal half of this hypothetical protein gene gene6772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6711 SCO6712 SCO6712 SC4C6.22 SC4C6.22 7466508 7467539 + copper oxidase SC4C6.22%2C possible copper oxidase%2C len: 343 aa%3B weakly similar to members of the multicopper oxidase family e.g. to the N-terminus of SW:COPA_PSESM (EMBL:M19930)%2C CopA%2C Pseudomonas syringae copper resistance protein A precursor (609 aa)%2C fasta scores%3B opt: 170 z-score: 188.4 E(): 0.0036%2C 27.3%25 identity in 205 aa overlap. Also weakly similar to the blood coagulation factors which are structurally related to the multicopper oxidases. Similar to the N-terminus of TR:O53858 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical protein (504 aa) (25.1%25 identity in 323 aa overlap). Contains PS00079 Multicopper oxidases signature 1 and PS00080 Multicopper oxidases signature 2 (the latter suggesting copper-binding) gene gene6773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6712 SCO6713 SCO6713 SC4C6.23 SC4C6.23 7467726 7468784 + transcriptional regulator SC4C6.23%2C probable lacI-family transcriptional regulator%2C len: 352 aa%3B similar to many e.g. TR:O87590 (EMBL:AF086819)%2C CelR%2C Thermomonospora fusca transcriptional regulator of cellulase genes (340 aa)%2C fasta scores%3B opt: 991 z-score: 1119.2 E(): 0%2C 51.9%25 identity in 324 aa overlap. Similar to others from S. coelicolor e.g. TR:O86795 (EMBL:AL031317) S. coelicolor transcriptional regulator (355 aa) (36.3%25 identity in 342 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and LacI family and to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family. Contains probable helix-turn-helix motif at aa 9-30 (Score 2307%2C +7.04 SD) gene gene6774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6713 SCO6714 SCO6714 SC4C6.24c SC4C6.24c 7468890 7469681 - hydroxylase SC4C6.24c%2C possible hydroxylase%2C len: 263 aa%3B similar to TR:Q55078 (EMBL:U50973) Streptomyces sp. strain C5 daunomycin C-14 hydroxylase (275 aa)%2C fasta scores%3B opt: 422 z-score: 482.3 E(): 1.5e-19%2C 38.5%25 identity in 273 aa overlap. Similar to TR:O50527 (EMBL:AL009204) S.coelicolor hypothetical protein (267 aa) (37.9%25 identity in 253 aa overlap) and to (EMBL:AL049863)%2C SC5H1.09c%2C S.coelicolor possible hydroxylase (265 aa) (35.7%25 identity in 258 aa overlap). Also similar to hypothetical proteins from Mycobacterium tuberculosis and to Mycobacterium tuberculosis 27.3 kDa MAb HBT7 reactive antigen (EMBL:AJ007737) (260 aa) (36.7%25 identity in 264 aa overlap) gene gene6775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6714 SCO6715 SCO6715 SC4C6.25 SC4C6.25 7469875 7470120 + transcriptional regulator SC4C6.25%2C probable transcriptional regulator%2C len: 81 aa%2C similar to many transcriptional regulators (some ) from Streptomyces e.g. TR:Q53963 (EMBL:X62287)%2C WhiB%2C S.coelicolor transcriptional regulator essential for sporulation (87 aa)%2C fasta scores%3B opt: 336 z-score: 452.7 E(): 5.7e-18%2C 61.1%25 identity in 72 aa overlap. Also similar to e.g. TR:O69649 (EMBL:AL02212) Mycobacterium tuberculosis regulatory protein (100 aa) (40.0%25 identity in 75 aa overlap) gene gene6776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6715 SCO6716 SCO6716 SC4C6.26 SC4C6.26 7470453 7470647 + hypothetical protein SC4C6.26%2C hypothetical protein%2C len: 64 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame plot and amino acid composition gene gene6777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6716 SCO6717 SCO6717 SC4C6.27c SC4C6.27c 7470692 7471678 - acyl-ACP desaturase SC4C6.27c%2C probable acyl-[acyl-carrier protein] desaturase%2C len: 328 aa%3B similar to many e.g. SW:STAD_LINUS (EMBL:X70962) Linum usitatissimum stearoyl-ACP desaturase (396 aa)%2C fasta scores%3B opt: 385 z-score: 461.5 E(): 2.2e-18%2C 30.2%25 identity in 311 aa overlap. The N-terminal 100 aa are divergent. Highest similarity to TR:Q50050 (EMBL:U15182)%2C aadX%2C Mycobacterium leprae protein (338 aa) (45.5%25 identity in 325 aa overlap) and TR:Q50824 (EMBL:AL022004)%2C des%2C Mycobacterium tuberculosis protein (338 aa) (46.1%25 identity in 323 aa overlap). Contains TTA (leucine) codon%2C possible target for bldA regulation gene gene6778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6717 SCO6718 SCO6718 ddah ddah 7471875 7472651 - dimethylarginine dimethylaminohydrolase SC5F2A.01c%2C ddah%2C dimethylarginine dimethylaminohydrolase%2C len: 258 aa%3B hydrolyses asymmetrically methylated arginine with preference for dimethylated arginine over monomethylated arginine (experimental). Similar to TR:D1038106 (EMBL:AB001915) NG%2CNG-dimethylarginine dimethylaminohydrolase from Homo sapiens (285 aa) fasta scores%3B opt: 323%2C z-score: 384.7%2C E(): 4.1e-14%2C (35.7%25 identity in 272 aa overlap). gene gene6779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6718 SCO6719 SCO6719 SC5F2A.02c SC5F2A.02c 7472768 7475026 - UvrA-like ABC transporter SC5F2A.02c%2C UvrA-like ABC transporter%2C len: 752 aa%3B similar to many egs. TR:O86699 (EMBL:AL031515) UvrA-like protein from Streptomyces coelicolor (796 aa) fasta scores%3B opt: 2047%2C z-score: 2164.0%2C E(): 0%2C (51.9%25 identity in 776 aa overlap) and SW:UVRA_ECOLI UvrA%2C excinuclease ABC subunit A from Escherichia coli (940 aa) fasta scores%3B opt: 634%2C z-score: 669.2%2C E(): 5.8e-30%2C (33.9%25 identity in 938 aa overlap). Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible membrane spanning hydrophobic regions. gene gene6780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6719 SCO6720 SCO6720 SC5F2A.03c SC5F2A.03c 7475037 7476671 - ABC transporter SC5F2A.03c%2C probable ABC transporter%2C len: 544aa%3B similar to many involved in antibiotic resistance egs. TR:Q54381 (EMBL:X79146) from the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11 (578 aa) fasta scores%3B opt: 1624%2C z-score: 1696.3%2C E(): 0%2C (50.3%25 identity in 541 aa overlap). Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter%2C two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature. Also contains a possible coiled-coil region around 250aa. gene gene6781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6720 SCO6721 SCO6721 SC5F2A.04 SC5F2A.04 7476734 7477642 + hypothetical protein SC5F2A.04%2C possible integral membrane protein%2C len: 302aa%3B contains possible membrane spanning hydrophobic regions. gene gene6782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6721 SCO6722 SCO6722 SC5F2A.05c SC5F2A.05c 7477705 7478121 - regulator SC5F2A.05c%2C possible regulator%2C len: 138aa%3B similar to TR:P95753 (EMBL:D50051) SsgA protein associated with sporulation and cell division in Streptomyces griseus (136 aa) fasta scores%3B opt: 233%2C z-score: 312.5%2C E(): 4.3e-10%2C (33.9%25 identity in 115 aa overlap). gene gene6783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6722 SCO6723 SCO6723 SC5F2A.06 SC5F2A.06 7478448 7479494 + oxidoreductase SC5F2A.06%2C possible oxidoreductase (hypothetical protein)%2C len: 348 aa%3B weakly similar to many eg. SW:MQO_ECOLI probable malate:quinone oxidoreductase from Escherichia coli (548 aa) fasta scores%3B opt: 114%2C z-score: 126.7%2C E(): 9.7%2C (30.3%25 identity in 119 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene6784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6723 SCO6724 SCO6724 SC5F2A.07 SC5F2A.07 7479567 7479896 + hypothetical protein SC5F2A.07%2C unknown%2C len: 109 aa gene gene6785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6724 SCO6725 SCO6725 SC5F2A.08c SC5F2A.08c 7479906 7480202 - hypothetical protein SC5F2A.08c%2C unknown%2C len: 98 aa%3B similar to TR:P73587 (EMBL:D90907) hypothetical protein from Synechocystis sp. PCC6803 (89 aa) fasta scores%3B opt: 99%2C z-score: 148.0%2C E(): 0.62%2C (31.8%25 identity in 88 aa overlap). gene gene6786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6725 SCO6726 SCO6726 SC5F2A.09 SC5F2A.09 7480244 7480945 + endonuclease SC5F2A.09%2C possible endonuclease%2C len: 233aa%3B similar to SW:NFI_ECOLI endonuclease V from Escherichia coli (223 aa) fasta scores%3B opt: 468%2C z-score: 541.7%2C E(): 7.4e-23%2C (38.6%25 identity in 215 aa overlap). gene gene6787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6726 SCO6727 SCO6727 SC5F2A.10c SC5F2A.10c 7480933 7481103 - hypothetical protein SC5F2A.10c%2C unknown%2C len: 56 aa gene gene6788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6727 SCO6728 SCO6728 SC5F2A.11 SC5F2A.11 7481296 7481442 + hypothetical protein SC5F2A.11%2C membrane protein%2C len: 48 aa. Contains possible hydrophobic membrane spanning region gene gene6789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6728 SCO6729 SCO6729 SC5F2A.12c SC5F2A.12c 7481508 7482698 - hypothetical protein SC5F2A.12c%2C membrane protein%2C len: 396 aa%3B similar to many e.g. TR:O53176 (EMBL:AL021246) hypothetical protein from Mycobacterium tuberculosis (419 aa) fasta scores%3B opt: 528%2C z-score: 598.4%2C E(): 5.1e-26%2C (41.0%25 identity in 420 aa overlap). Contains possible hydrophobic membrane spanning region gene gene6790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6729 SCO6730 SCO6730 SC5F2A.13 SC5F2A.13 7482906 7484102 + racemase SC5F2A.13%2C possible racemase%2C len: 398aa%3B similar to many egs. TR:O06543 (EMBL:Z95584) hypothetical protein from Mycobacterium tuberculosis (360 aa) fasta scores%3B opt: 1338%2C z-score: 1408.4%2C E(): 0%2C (57.1%25 identity in 361 aa overlap) and TR:O09176 (EMBL:U89906) alpha-methylacyl-CoA racemase from Mus musculus (moues) (361 aa) fasta scores%3B opt: 953%2C z-score: 1005.2%2C E(): 0%2C (44.2%25 identity in 344 aa overlap). Also similar to SC6A5.34 (EMBL:AL049485) probable fatty acid co-A racemase from Streptomyces coelicolor (387 aa) fasta scores%3B opt: 1787%2C z-score: 1558.9%2C E(): 0%2C (69.9%25 identity in 382 aa overlap). gene gene6791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6730 SCO6731 SCO6731 SC5F2A.14 SC5F2A.14 7484114 7485328 + acetyl-CoA acetyltransferase Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase%2C catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation gene gene6792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6731 SCO6732 SCO6732 SC5F2A.15 SC5F2A.15 7485381 7487561 + fatty acid oxidative multifunctional enzyme SC5F2A.15%2C possible fatty acid oxidative multifunctional enzyme%2C len: 726aa%3B similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores%3B opt: 1174%2C z-score: 1211.3%2C E(): 0%2C (33.2%25 identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores%3B opt: 3034%2C z-score: 3128.4%2C E(): 0%2C (64.3%25 identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores%3B opt: 4069%2C z-score: 4004.0%2C E(): 0%2C (84.6%25 identity in 729 aa overlap). Contains Pfam matches to entries PF00725 3HCDH%2C 3-hydroxyacyl-CoA dehydrogenase and PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family and Prosite match to PS00923 Aspartate and glutamate racemases signature 1. gene gene6793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6732 SCO6733 SCO6733 SC5F2A.16c SC5F2A.16c 7487571 7488326 - transcriptional regulator SC5F2A.16c%2C possible transcriptional regulator%2C len: 251aa%3B similar to many eg. SW:SOXR_PSEAE SoxR regulator of the superoxide response regulon (156 aa) fasta scores%3B opt: 181%2C z-score: 219.0%2C E(): 6.9e-05%2C (37.1%25 identity in 105 aa overlap). Contains probable helix-turn-helix motif (+3.41 SD) 28-49aa. gene gene6794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6733 SCO6734 SCO6734 SC5F2A.17 SC5F2A.17 7488549 7490018 + L-asparagine permease SC5F2A.17%2C probable amino acid permease%2C len: 489aa%3B similar to many especially SW:ANSP_SALTY AnsP%2C L-asparagine permease from Salmonella enterica (497 aa) fasta scores%3B opt: 1886%2C z-score: 2042.9%2C E(): 0%2C (58.6%25 identity in 476 aa overlap). Contains Pfam match to entry PF00324 aa_permeases%2C Amino acid permease and Prosite match to PS00218 Amino acid permeases signature. Also contains several probable membrane spanning hydrophobic regions. gene gene6795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6734 SCO6735 SCO6735 SC5F2A.18 SC5F2A.18 7490061 7490546 + hypothetical protein SC5F2A.18%2C unknown%2C len: 161 aa%3B some simlarity to SW:Y06D_BPT4 hypothetical protein from bacteriophage T4 (155 aa) fasta scores%3B opt: 135%2C z-score: 180.1%2C E(): 0.01%2C (20.9%25 identity in 158 aa overlap). gene gene6796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6735 SCO6736 SCO6736 SC5F2A.19c SC5F2A.19c 7490559 7492079 - metallopeptidase SC5F2A.19c%2C possible metallopeptidase%2C len: 506aa%3B similar to many egs. TR:O69971 (EMBL:AL022268) proposed zinc metallopeptidase from Streptomyces coelicolor (512 aa) fasta scores%3B opt: 934%2C z-score: 1039.4%2C E(): 0%2C (36.3%25 identity in 509 aa overlap) and TR:G4063364 (EMBL:AF081952) from Thermoplasma acidophilum (780 aa) fasta scores%3B opt: 387%2C z-score: 428.8%2C E(): 1.4e-16%2C (28.2%25 identity in 447 aa overlap). Contains PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. gene gene6797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6736 SCO6737 SCO6737 SC5F2A.20 SC5F2A.20 7492215 7492493 + hypothetical protein SC5F2A.20%2C small proline-rich protein%2C len: 92 aa gene gene6798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6737 SCO6738 SCO6738 SC5F2A.21 SC5F2A.21 7492490 7493788 + carboxypeptidase SC5F2A.21%2C possible carboxypeptidase (hypothetical protein)%2C len: 432 aa%3B weak similarity to many e.g. SW:CBPS_STRCP zinc carboxypeptidase from Streptomyces capreolus (434 aa) fasta scores%3B opt: 153%2C z-score: 178.1%2C E(): 0.013%2C (23.5%25 identity in 136 aa overlap). Contains possible N-terminal region signal peptide sequence gene gene6799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6738 SCO6739 SCO6739 SC5F2A.22 SC5F2A.22 7493869 7495605 + BCCT family transporter SC5F2A.22%2C probable BCCT family transporter%2C len: 578aa%3B similar to many eg. SW:OPUD_BACSU glycine/betaine transporter%2C OpuD from Bacillus subtilis (512 aa) fasta scores%3B opt: 1414%2C z-score: 1650.4%2C E(): 0%2C (43.9%25 identity in 492 aa overlap). Contains Prosite match to PS01303 BCCT family of transporters signature. Also contains several probable membrane spanning hydrophobic regions. gene gene6800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6739 SCO6740 SCO6740 SC5F2A.23c SC5F2A.23c 7495638 7496600 - D-amino acid oxidase SC5F2A.23c%2C probable D-amino acid oxidase ()%2C len: 320 aa%3B similar to many both prokaryote and eukaryote egs. TR:O33145 (EMBL:AJ000521) D-amino acid oxidase from Mycobacterium tuberculosis (320 aa) fasta scores%3B opt: 805%2C z-score: 892.7%2C E(): 0%2C (43.4%25 identity in 316 aa overlap) and SW:OXDD_HUMAN D-aspartate oxidase from Homo sapiens (341 aa) fasta scores%3B opt: 548%2C z-score: 609.9%2C E(): 1.2e-26%2C (36.4%25 identity in 327 aa overlap). Contains Pfam match to entry PF01266 DAO%2C D-amino acid oxidase and Prosite match to PS00677 D-amino acid oxidases signature. Also contains probable N-terminal signal sequence. gene gene6801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6740 SCO6741 SCO6741 SC5F2A.24 SC5F2A.24 7496667 7497704 + oxidoreductase SC5F2A.24%2C possible oxidoreductase%2C len: 345aa%3B similar to SW:KAS2_STRGA beta-ketoacyl synthase from Streptomyces glaucescens (409 aa) fasta scores%3B opt: 131%2C z-score: 153.7%2C E(): 0.3%2C (29.9%25 identity in 251 aa overlap). gene gene6802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6741 SCO6742 SCO6742 SC5F2A.25 SC5F2A.25 7497718 7499361 + ABC transporter ATP-binding protein SC5F2A.25%2C probable ABC transporter%2C len: 547aa%3B similar to many eg. TR:Q53912 (EMBL:X84374) Ard1%2C ABC transporter which confers resistance to the aminonucleoside antibiotic A201A in Streptomyces capreolus (558 aa) fasta scores%3B opt: 1561%2C z-score: 1661.3%2C E(): 0%2C (46.7%25 identity in 542 aa overlap). Contains two Pfam matches to entry PF00005 ABC_tran%2C ABC transporter%2C two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and Prosite match to PS00211 ABC transporters family signature. gene gene6803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6742 SCO6743 SCO6743 SC5F2A.26c SC5F2A.26c 7499508 7501850 - transcriptional accessory protein SC5F2A.26c%2C possible transcriptional accessory protein%2C len: 780aa%3B similar to SW:TEX_BORPE Tex%2C transcriptional accessory protein (exact function not known) from Bordetella pertussis (791 aa) fasta scores%3B opt: 2905%2C z-score: 2938.8%2C E(): 0%2C (59.5%25 identity in 781 aa overlap). Also similar to hypothetical proteins eg. SW:YHGF_ECOLI from Escherichia coli fasta scores%3B opt: 2888%2C z-score: 2922.0%2C E(): 0%2C (61.2%25 identity in 744 aa overlap). Contains Pfam match to entry PF00575 S1%2C S1 RNA binding domain. gene gene6804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6743 SCO6744 SCO6744 SC5F2A.27 SC5F2A.27 7501897 7502100 + hypothetical protein SC5F2A.27%2C unknown%2C len: 67 aa gene gene6805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6744 SCO6745 SCO6745 SC5F2A.28c SC5F2A.28c 7502204 7503082 - hypothetical protein SC5F2A.28c%2C alanine-rich hypothetical protein%2C len: 292 aa%3B similar to TR:Q9AK27 (EMBL:AL589164) Streptomyces coelicolor hypothetical protein 2SCK8.25%2C 292 aa%3B fasta scores: opt: 716 Z-score: 806.0 E(): 2.9e-37%3B 44.891%25 identity in 274 aa overlap gene gene6806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6745 SCO6746 SCO6746 SC5F2A.29 SC5F2A.29 7503189 7504166 + transcriptional regulator SC5F2A.29%2C possible transcriptional regulator%2C len: 325aa%3B similar to many eg. TR:O30507 (EMBL:AF008308) arginine regulatory protein ArgR%2C from Pseudomonas aeruginosa (328 aa) fasta scores%3B opt: 288%2C z-score: 331.0%2C E(): 4e-11%2C (24.7%25 identity in 308 aa overlap). Also similar to TR:Q43970 (EMBL:Z48959) AraC-like protein from Azorhizobium caulinodans (227 aa) fasta scores%3B opt: 605%2C z-score: 689.7%2C E(): 4.2e-31%2C (47.4%25 identity in 192 aa overlap). Contains Pfam match to entry PF00165 HTH_2%2C Bacterial regulatory helix-turn-helix proteins%2C araC family. gene gene6807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6746 SCO6747 SCO6747 SC5F2A.30 SC5F2A.30 7504216 7504851 + hypothetical protein SC5F2A.30%2C unknown%2C len: 211aa%3B similar to TR:P71709 (EMBL:Z80775) hypothetical protein from Mycobacterium tuberculosis (187 aa) fasta scores%3B opt: 529%2C z-score: 638.6%2C E(): 2.9e-28%2C (49.5%25 identity in 182 aa overlap) and to TR:AAK44280 (EMBL:AE006918) Mycobacterium tuberculosis CDC1551 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis%2C MT0058%2C 212 aa%3B fasta scores: opt: 619 Z-score: 715.6 E(): 3.2e-32%3B 50.242%25 identity in 207 aa overlap gene gene6808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6747 SCO6748 SCO6748 SC5F2A.31c SC5F2A.31c 7504838 7505611 - enoyl CoA hydratase SC5F2A.31c%2C possible enoyl coA hydratase%2C len: 257aa%3B similar to many proposed to be enoyl coA hydratase based on Pfam match eg. TR:P97087 (EMBL:Z92974) from Clostridium thermosaccharolyticum (259 aa) fasta scores%3B opt: 426%2C z-score: 496.6%2C E(): 2.4e-20%2C (31.2%25 identity in 247 aa overlap). Contains Pfam match to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family. gene gene6809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6748 SCO6749 SCO6749 SC5F2A.32 SC5F2A.32 7505756 7506241 + hypothetical protein SC5F2A.32%2C unknown%2C len: 161 aa%3B similar to other hypothetical proteins egs. TR:O54111 (EMBL:AL021529) from Streptomyces coelicolor (171 aa) fasta scores%3B opt: 221%2C z-score: 281.8%2C E(): 2.2e-08%2C (35.8%25 identity in 137 aa overlap) and TR:O69204 (EMBL:U33059) Actinosynnema pretiosum auranticum (144 aa) fasta scores%3B opt: 220%2C z-score: 281.8%2C E(): 2.2e-08%2C (38.7%25 identity in 155 aa overlap). gene gene6810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6749 SCO6750 SCO6750 SC5F2A.33c SC5F2A.33c 7506308 7506901 - isopentenyl-diphosphate delta-isomerase catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate gene gene6811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6750 SCO6751 SCO6751 SC5F2A.34c SC5F2A.34c 7507178 7508116 - efflux protein SC5F2A.34c%2C possible efflux protein%2C len: 312aa%3B similar to many eg. SW:CZCD_ALCSP cation efflux protein from Alcaligenes sp. (316 aa) fasta scores%3B opt: 834%2C z-score: 949.4%2C E(): 0%2C (47.0%25 identity in 300 aa overlap). Contains several probable membrane spanning hydrophobic regions. gene gene6812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6751 SCO6752 SCO6752 SC5F2A.35 SC5F2A.35 7508594 7510411 + integral membrane transferase SC6A5.01%2C partial CDS%2C possible integral membrane transferase%2C len: >490aa%3B similar to TR:O67379 (EMBL:AE000737) glucose-1-phosphate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores%3B opt: 215%2C z-score: 245.5%2C E(): 2.2e-06%2C (26.2%25 identity in 210 aa overlap). Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature and possible membrane spanning hydrophobic regions.~SC5F2A.35%2C partial CDS%2C possible transferase%2C len: >148aa%3B C-terminal region lies on cosmid 6A5 (EMBL:AL049485). Similar over a defined region to many proposed/hypothetical proteins eg. TR:O67379 (EMBL:AE000737) proposed glucose-1-phosphate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores%3B opt: 215%2C z-score: 239.5%2C E(): 5e-06%2C (26.2%25 identity in 210 aa overlap). Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature. Also contains possible membrane spanning hydrophobic regions. gene gene6813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6752 SCO6753 SCO6753 SC6A5.02 SC6A5.02 7510408 7511160 + nucleotide sugar-1-phosphate transferase SC6A5.02%2C probable nucleotide sugar-1-phosphate transferase%2C len: 250aa%3B similar to many eg. TR:O05171 (EMBL:Y11985) dNDP-glucose synthase from the avilamycin biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 (355 aa) fasta scores%3B opt: 192%2C z-score: 226.4%2C E(): 2.6e-05. (26.9%25 identity in 242 aa overlap). Contains Pfam match to entry PF00483 NTP_transferase%2C Nucleotidyl transferase. gene gene6814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6753 SCO6754 SCO6754 SC6A5.03 SC6A5.03 7511187 7512209 + glycerol dehydrogenase SC6A5.03%2C possible glycerol dehydrogenase%2C len: 340aa%3B similar to many eg. SW:GLDA_PSEPU glycerol dehydrogenase%2C GldA%2C from Pseudomonas putida (365 aa) fasta scores%3B opt: 261%2C z-score: 303.7%2C E(): 1.3e-09%2C (27.9%25 identity in 308 aa overlap). gene gene6815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6754 SCO6755 SCO6755 SC6A5.04 SC6A5.04 7512283 7512966 + transferase SC6A5.04%2C possible integral membrane transferase%2C len: 227aa%3B similar to many eg. TR:O67379 (EMBL:AE000737) glucose-1-phophate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores%3B opt: 206%2C z-score: 257.3%2C E(): 5e-07%2C (28.1%25 identity in 199 aa overlap). Contains possible membrane spanning hydrophobic region. gene gene6816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6755 SCO6756 SCO6756 SC6A5.05 SC6A5.05 7512975 7513847 + glycosyltransferase SC6A5.05%2C possible glycosyltransferase%2C len: 290aa%3B similar to many eg. TR:E1388141 (EMBL:AL035478) transferase from Streptomyces coelicolor (344 aa) fasta scores%3B opt: 202%2C z-score: 235.1%2C E(): 8.6e-06%2C (28.1%25 identity in 317 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2%2C Glycosyl transferases. Contains possible membrane spanning hydrophobic regions. gene gene6817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6756 SCO6757 SCO6757 SC6A5.06 SC6A5.06 7513947 7514876 + ABC transporter membrane protein SC6A5.06%2C probable ABC transporter membrane component%2C len: 309aa%3B similar to many eg. TR:O66230 (EMBL:AB010150) ABC transporter membrane component from Escherichia coli (264 aa) fasta scores%3B opt: 346%2C z-score: 414.3%2C E(): 8.9e-16%2C (27.3%25 identity in 267 aa overlap). Contains Pfam match to entry PF01061 ABC2_membrane%2C ABC-2 type transporter%2C score 109.60%2C E-value 6.1e-29 and Prosite match to PS00211 ABC transporters family signature. Also contains probable membrane spanning hydrophobic regions. gene gene6818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6757 SCO6758 SCO6758 SC6A5.07 SC6A5.07 7514896 7515657 + ABC transporter ATP-binding protein SC6A5.07%2C probable ABC transporter ATP-binding component%2C len: 253aa%3B similar to many eg. SW:TAGH_BACSU TagH%2C ABC transporter ATP-binding component from Bacillus subtilis (527 aa) fasta scores%3B opt: 621%2C z-score: 686.7%2C E(): 6e-31%2C (48.5%25 identity in 202 aa overlap). Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter%2C score 123.70%2C E-value 3.4e-33 and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. gene gene6819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6758 SCO6759 SCO6759 SC6A5.08 SC6A5.08 7516017 7516928 + phytoene synthase SC6A5.08%2C probable phytoene synthase%2C len: 303aa%3B similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores%3B opt: 322%2C z-score: 379.7%2C E(): 7.5e-14%2C (31.8%25 identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY%2C Squalene and phytoene synthases%2C score 34.70%2C E-value 1.2e-08. gene gene6820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6759 SCO6760 SCO6760 SC6A5.09 SC6A5.09 7516937 7517875 + phytoene synthase SC6A5.09%2C probable phytoene synthase%2C len: 312aa%3B similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores%3B opt: 791%2C z-score: 925.6%2C E(): 0%2C (48.3%25 identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores%3B opt: 493%2C z-score: 577.3%2C E(): 7.4e-25%2C (34.4%25 identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY%2C Squalene and phytoene synthases%2C score 168.70%2C E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthases signature 1 and PS01045 Squalene and phytoene synthases signature 2. gene gene6821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6760 SCO6761 SCO6761 SC6A5.10 SC6A5.10 7517875 7518033 + hypothetical protein SC6A5.10%2C unknown%2C len: 52 aa%3B designated based upon Hidden-Markov Model and probable ribosome binding site. gene gene6822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6761 SCO6762 SCO6762 SC6A5.11 SC6A5.11 7518030 7519466 + phytoene dehydrogenase SC6A5.11%2C possible phytoene dehydrogenase%2C len: 478aa%3B similar to many from eukaryotes eg. SW:CRTI_CAPAN phytoene dehydrogenase precursor from Capsicum annuum (bell pepper) (582 aa) fasta scores%3B opt: 276%2C z-score: 302.1%2C E(): 1.6e-09%2C (24.0%25 identity in 459 aa overlap). Also similar to prokaryotes eg. TR:P72449 (EMBL:X95596) proposed dehydrogenase from a cryptic carotenoid biosynthesis cluster in Streptomyces griseus (517 aa) fasta scores%3B opt: 206%2C z-score: 226.8%2C E(): 2.5e-05%2C (29.7%25 identity in 512 aa overlap) gene gene6823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6762 SCO6763 SCO6763 SC6A5.12 SC6A5.12 7519463 7520599 + polyprenyl synthatase SC6A5.12%2C probable polyprenyl synthatase%2C len: 378aa%3B similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores%3B opt: 1103%2C z-score: 1231.0%2C E(): 0%2C (49.3%25 identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores%3B opt: 547%2C z-score: 614.0%2C E(): 6.7e-27%2C (38.2%25 identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt%2C Polyprenyl synthetases%2C score 176.70%2C E-value 3.9e-49 and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop)%2C PS00723 Polyprenyl synthetases signature 1 and PS00606 Beta-ketoacyl synthases active site. gene gene6824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6763 SCO6764 SCO6764 SC6A5.13 SC6A5.13 7520716 7522758 + squalene-hopene cyclase SC6A5.13%2C probable squalene-hopene cyclase%2C len: 680 aa%3B similar to many e.g. SW:SQHC_ALIAC squalene-hopene cyclase A key enzyme in triterpenoid metabolism in Bacillus acidocaldarius (630 aa) fasta scores%3B opt: 2153%2C z-score: 2386.3%2C E(): 0%2C (51.8%25 identity in 620 aa overlap). Contains two Pfam matches to entry PF00432 prenyltrans%2C Prenyltransferase and squalene oxidase repeats and a Prosite match to PS01074 Terpene synthases signature. gene gene6825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6764 SCO6765 SCO6765 SC6A5.14 SC6A5.14 7522758 7523399 + lipoprotein SC6A5.14%2C possible lipoprotein%2C len: 213 aa%3B similar to SW:TYRT_STRLN proposed tyrosinase co-factor from the melanin biosynthesis in Streptomyces lincolnensis (140 aa) fasta scores%3B opt: 115%2C z-score: 142.8%2C E(): 1.2%2C (29.2%25 identity in 120 aa overlap). Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene6826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6765 SCO6766 SCO6766 SC6A5.15 SC6A5.15 7523406 7524428 + hypothetical protein SC6A5.15%2C unknown%2C len: 340 aa%3B similar to many of undefined function e.g. TR:P95416 (EMBL:D84475) NirJ%2C from a locus for heme D1 biosynthesis in Pseudomonas aeruginosa (387 aa) fasta scores%3B opt: 222%2C z-score: 264.2%2C E(): 2.1e-07%2C (24.2%25 identity in 207 aa overlap). gene gene6827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6766 SCO6767 SCO6767 ispG ispG 7524433 7525587 + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase catalyzes the conversion of 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate%3B involved in isoprenoid synthesis gene gene6828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6767 SCO6768 SCO6768 SC6A5.17 SC6A5.17 7525613 7527583 + 1-deoxy-D-xylulose-5-phosphate synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate gene gene6829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6768 SCO6769 SCO6769 SC6A5.18 SC6A5.18 7527584 7528969 + aminotransferase SC6A5.18%2C probable aminotransferase%2C len: 461 aa%3B similar to many e.g. SW:ARGD_BACSU acetylornithine aminotransferase from Bacillus subtilis (385 aa) fasta scores%3B opt: 663%2C z-score: 757.6%2C E(): 0%2C (37.8%25 identity in 341 aa overlap). Contains Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate and Prosite match to PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. gene gene6830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6769 SCO6770 SCO6770 SC6A5.19 SC6A5.19 7529043 7529657 + DNA-binding protein SC6A5.19%2C probable DNA-binding protein%2C len: 204 aa%3B similar to several of undefined function eg. TR:O86784 (EMBL:AL031317) hypothetical protein from Streptomyces coelicolor (201 aa) fasta scores%3B opt: 297%2C z-score: 356.2%2C E(): 1.5e-12%2C (34.9%25 identity in 212 aa overlap). Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. gene gene6831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6770 SCO6771 SCO6771 SC6A5.20 SC6A5.20 7529654 7529773 + small hydrophobic hypothetical protein SC6A5.20%2C possible small hydrophobic hypothetical protein%2C len: 39 aa%3B contains possible N-terminal signal sequence. gene gene6832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6771 SCO6772 SCO6772 SC6A5.21c SC6A5.21c 7529795 7530658 - hypothetical protein SC6A5.21c%2C unknown%2C len: 287aa%3B similar to TR:P96830 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (276 aa) fasta scores%3B opt: 189%2C z-score: 220.4%2C E(): 5.6e-05%2C (32.3%25 identity in 279 aa overlap). gene gene6833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6772 SCO6773 SCO6773 SC6A5.22 SC6A5.22 7531179 7532117 + peptidase SC6A5.22%2C possible peptidase%2C len: 312aa%3B TR:E1355668 (EMBL:AL034355) peptidase from Streptomyces coelicolor (349 aa) fasta scores%3B opt: 452%2C z-score: 416.6%2C E(): 6.6e-16%2C (34.5%25 identity in 319 aa overlap) and SW:ALE1_STACP glycylglycine endopeptidase from Staphylococcus capitis (362 aa) fasta scores%3B opt: 332%2C z-score: 309.4%2C E(): 6.2e-10%2C (35.2%25 identity in 196 aa overlap). Contains probable N-terminal signal sequence. gene gene6834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6773 SCO6774 SCO6774 SC6A5.23 SC6A5.23 7532361 7533146 + hypothetical protein SC6A5.23%2C unknown%2C len: 261aa%3B similar to TR:O07156 (EMBL:Z96801) hypothetical protein from Mycobacterium leprae (301 aa) fasta scores%3B opt: 496%2C z-score: 562.4%2C E(): 5e-24%2C (36.4%25 identity in 253 aa overlap) gene gene6835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6774 SCO6775 SCO6775 SC6A5.24c SC6A5.24c 7533249 7533869 - transcriptional regulator SC6A5.24c%2C probable transcriptional regulator%2C len: 206 aa%3B similar to many e.g. TR:O86510 (EMBL:AL031124) transcriptional regulator from Streptomyces coelicolor (200 aa) fasta scores%3B opt: 328%2C z-score: 399.0%2C E(): 6.4e-15%2C (34.9%25 identity in 186 aa overlap) and SW:BETI_ECOLI regulatory protein BetI from the osmoregulatory choline-glycine/betaine pathway of Escherichia coli (195 aa) fasta scores%3B opt: 158%2C z-score: 198.8%2C E(): 0.0009%2C (25.0%25 identity in 180 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and probable helix-turn-helix (+3.31 SD) 32-53 aa gene gene6836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6775 SCO6776 SCO6776 SC6A5.25 SC6A5.25 7534102 7535214 + hypothetical protein SC6A5.25%2C unknown%2C len: 370 aa%3B similar to SW:YZ34_MYCTU hypothetical protein from Mycobacterium tuberculosis (372 aa) fasta scores%3B opt: 1125%2C z-score: 1301.0%2C E(): 0%2C (51.3%25 identity in 335 aa overlap). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop) gene gene6837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6776 SCO6777 SCO6777 SC6A5.26c SC6A5.26c 7535353 7536285 - beta-lactamase SC6A5.26c%2C possible beta-lactamase%2C len: 310 aa%3B similar to SW:BLA1_XANMA L1 metallo-beta-lactamase from Xanthomonas maltophilia (290 aa) fasta scores%3B opt: 161%2C z-score: 198.8%2C E(): 0.0009%2C (25.5%25 identity in 247 aa overlap). gene gene6838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6777 SCO6778 SCO6778 SC6A5.27c SC6A5.27c 7536362 7537048 - transcriptional regulator SC6A5.27c%2C probable transcriptional regulator%2C len: 228 aa%3B similar to many e.g. TR:O86514 (EMBL:AL031124) transcriptional regulator (194 aa) fasta scores%3B opt: 159%2C z-score: 206.2%2C E(): 0.00035%2C (28.5%25 identity in 151 aa overlap) and TR:Q54288 (EMBL:X86780) regulator of antibiotic transport complexes in Streptomyces hygroscopicus (204 aa) fasta scores%3B opt: 125%2C z-score: 163.8%2C E(): 0.08%2C (30.0%25 identity in 70 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and probable helix-turn-helix (+5.96 SD) 45-66aa. gene gene6839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6778 SCO6779 SCO6779 SC6A5.28c SC6A5.28c 7537178 7537378 - hypothetical protein SC6A5.28c%2C unknown%2C len: 66 aa%3B designated based upon %25GC and frameplot. gene gene6840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6779 SCO6780 SCO6780 SC6A5.29 SC6A5.29 7537508 7538713 + hypothetical protein SC6A5.29%2C possible hypothetical protein%2C len: 401 aa. Contains possible N-terminal region signal peptide sequence gene gene6841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6780 SCO6781 SCO6781 SC6A5.30c SC6A5.30c 7538739 7539953 - regulatory protein SC6A5.30c%2C possible regulatory protein%2C len: 404 aa%3B varying levels of similarity to hypothetical proteins and proposed regulators e.g. TR:P95251 (EMBL:Z84498) hypothetical protein from Mycobacterium tuberculosis (406 aa) fasta scores%3B opt: 319%2C z-score: 348.9%2C E(): 3.9e-12%2C (29.6%25 identity in 372 aa overlap) and TR:O24741 (EMBL:AB001683) receptor for an extracellular regulatory factor from Streptomyces sp. strain FRI-5 (221 aa) fasta scores%3B opt: 165%2C z-score: 187.4%2C E(): 0.0039%2C (43.9%25 identity in 82 aa overlap). Contains two Pfam matches to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a Prosite match to PS01081 Bacterial regulatory proteins%2C tetR family signature. Also contains 2 probable helix-turn-helix (+4.73 SD) 246-267aa and (+4.37 SD) 53-73 aa gene gene6842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6781 SCO6782 SCO6782 SC6A5.31c SC6A5.31c 7540064 7541155 - zinc-binding alcohol dehydrogenase SC6A5.31c%2C probable zinc-binding alcohol dehydrogenase%2C len: 363aa%3B similar to many eg. TR:Q59096 (EMBL:U61983) benzyl alcohol dehydrogenase from Acinetobacter calcoaceticus (371 aa) fasta scores%3B opt: 948%2C z-score: 937.8%2C E(): 0%2C (42.8%25 identity in 360 aa overlap). Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases and Prosite match to PS00059 Zinc-containing alcohol dehydrogenases signature. gene gene6843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6782 SCO6783 SCO6783 SC6A5.32c SC6A5.32c 7541152 7541619 - hypothetical protein SC6A5.32c%2C unknown%2C len: 155 aa%3B similar to TR:Q55966 (EMBL:D64005) hypothetical protein from Synechocystis sp. PCC6803 (180 aa) fasta scores%3B opt: 161%2C z-score: 214.8%2C E(): 0.00012%2C (28.3%25 identity in 180 aa overlap). gene gene6844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6783 SCO6784 SCO6784 SC6A5.33c SC6A5.33c 7541642 7542313 - regulatory protein SC6A5.33c%2C possible regulatory protein%2C len: 223 aa%3B similar to hypothetical proteins e.g. TR:P96839 (EMBL:Z92774) from Mycobacterium tuberculosis (200 aa) fasta scores%3B opt: 262%2C z-score: 321.3%2C E(): 1.4e-10%2C (29.1%25 identity in 182 aa overlap). Also short regions of similarity to regulatory proteins e.g. SW:TER8_PASMU tetracycline repressor protein from Pasteurella multocida (207 aa) fasta scores%3B opt: 152%2C z-score: 190.7%2C E(): 0.0025%2C (41.4%25 identity in 58 aa overlap). Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and probable helix-turn-helix (+2.65 SD) 44-6 5aa gene gene6845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6784 SCO6785 SCO6785 SC6A5.34 SC6A5.34 7542559 7543722 + fatty acid co-A racemase SC6A5.34%2C probable fatty acid co-A racemase%2C len: 387aa%3B similar to egs. TR:O06543 (EMBL:Z95584) hypothetical protein from Mycobacterium tuberculosis (360 aa) fasta scores%3B opt: 1304%2C z-score: 1373.1%2C E(): 0%2C (52.8%25 identity in 362 aa overlap) and TR:O09176 (EMBL:U89905) alpha-methylacyl-CoA racemase from rat liver (Rattus norvegicus) (361 aa) fasta scores%3B opt: 985%2C z-score: 1039.0%2C E(): 0%2C (44.4%25 identity in 342 aa overlap). gene gene6846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6785 SCO6786 SCO6786 SC6A5.35 SC6A5.35 7543722 7544747 + oxidoreductase SC6A5.35%2C possible oxidoreductase%2C len: 341aa%3B similar to many hypothetical proteins eg. TR:O53565 (EMBL:AL022022) from Mycobacterium tuberculosis (347 aa) fasta scores%3B opt: 800%2C z-score: 921.0%2C E(): 0%2C (38.9%25 identity in 339 aa overlap). Also similar to TR:O68447 (EMBL:AF041061) F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis (336 aa) fasta scores%3B opt: 198%2C z-score: 232.5%2C E(): 1.2e-05%2C (24.8%25 identity in 343 aa overlap). gene gene6847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6786 SCO6787 SCO6787 acdH3 acdH3 7544744 7545892 + acyl-CoA dehydrogenase SC6A5.36%2C acdH3%2C probable acyl-CoA dehydrogenase%2C len: 382 aa%3B similar to many (prokaryote and eukaryote) egs. TR:O33229 (EMBL:Z98209) probable acyl-CoA dehydrogenase from Mycobacterium tuberculosis (386 aa) fasta scores%3B opt: 1583%2C z-score: 1842.1%2C E(): 0%2C (62.7%25 identity in 378 aa overlap) and SW:ACDL_HUMAN acyl-CoA dehydrogenase from Homo sapiens (Human) (430 aa) fasta scores%3B opt: 1265%2C z-score: 1472.3%2C E(): 0%2C (51.8%25 identity in 380 aa overlap). Contains Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and Prosite matches to PS00072 Acyl-CoA dehydrogenases signature 1 and PS00073 Acyl-CoA dehydrogenases signature 2. gene gene6848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6787 SCO6788 SCO6788 SC6A5.37 SC6A5.37 7545965 7547179 + acetyl-CoA acetyltransferase Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase%2C catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation gene gene6849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6788 SCO6789 SCO6789 SC6A5.38 SC6A5.38 7547223 7549424 + fatty oxidation protein SC6A5.38%2C possible fatty oxidation protein%2C len: 733aa%3B similar to many eg. SW:FADB_ECOLI FadB%2C a multifunctional protein from the Escherichia coli fadBA operon%2C encoding the fatty acid-oxidizing multienzyme complex (729 aa) fasta scores%3B opt: 1119%2C z-score: 1146.7%2C E(): 0%2C (32.3%25 identity in 691 aa overlap). Contains Pfam matches to entry PF00378 ECH%2C Enoyl-CoA hydratase/isomerase family and entry PF00725 3HCDH%2C 3-hydroxyacyl-CoA dehydrogenase and a Prosite match to PS00923 Aspartate and glutamate racemases signature 1. gene gene6850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6789 SCO6790 SCO6790 SC6A5.39 SC6A5.39 7549461 7551299 + long chain fatty acid CoA ligase SC6A5.39%2C probable long chain fatty acid coA ligase%2C len: aa%3B similar to many eg. TR:E1359128 long chain fatty acid coA ligase from Streptomyces coelicolor (608 aa) fasta scores%3B opt: 943%2C z-score: 1037.6%2C E(): 0%2C (34.8%25 identity in 621 aa overlap) and SW:LCFX_RAT long chain fatty acid coA ligase from Rattus norvegicus (Rat) (697 aa) fasta scores%3B opt: 532%2C z-score: 584.9%2C E(): 2.8e-25%2C (28.0%25 identity in 626 aa overlap). Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and Prosite match to PS00455 AMP-binding domain signature. gene gene6851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6790 SCO6791 SCO6791 SC6A5.40c SC6A5.40c 7551380 7552519 - acyl-CoA dehydrogenase SC6A5.40c%2C partial CDS%2C probable acyl-coA dehydrogenase%2C len: 395aa%3B similar to many eg. TR:O34421 (EMBL:Z99113) from Bacillus subtilis (380 aa) fasta scores%3B opt: 777%2C z-score: 903.0%2C E(): 0%2C (36.6%25 identity in 383 aa overlap) and SW:ACDS_HUMAN acyl-coA dehydrogenase from Homo sapiens (Human) (412 aa) fasta scores%3B opt: 643%2C z-score: 747.6%2C E(): 0%2C (32.3%25 identity in 387 aa overlap). Contains three Pfam matches to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and a Prosite match to PS00072 Acyl-CoA dehydrogenases signature 1. gene gene6852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6791 SCO6792 SCO6792 SC1A2.01 SC1A2.01 7552594 7553190 + TetR family transcriptional regulator SC1A2.01%2C possible TetR-family transcriptional regulator%2C len: 198 aa. Weakly similar to Escherichia coli SW:UIDR_ECOLI (EMBL:M14641) UID operon repressor (GUS operon repressor) (196 aa)%2C fasta scores opt: 164 z-score: 213.3 E(): 0.00018 24.7%25 identity in 186 aa overlap. Also similar to Streptomyces coelicolor TR:CAB61186 (EMBL:AL132973) TetR-family transcriptional regulator%2C SCF91.29 (205 aa)%2C fasta scores opt: 265 z-score: 338.0 E(): 2e-11 34.1%25 identity in 185 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 33..54 (+5.25 SD). gene gene6853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6792 SCO6793 SCO6793 SC1A2.02c SC1A2.02c 7553214 7554719 - aldehyde dehydrogenase SC1A2.02c%2C probable aldehyde dehydrogenase%2C len: 501 aa. Similar to many dehydrogenases e.g. Rhizobium sp. (strain NGR234) SW:GABD_RHISN(EMBL:AE000096) probable succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) (491 aa)%2C fasta scores opt: 812 z-score: 864.8 E():0 33.3%25 identity in 468 aa overlap and Streptomyces coelicolor TR:Q9ZBH2(EMBL:AL035206) aldehyde dehydrogenase%2C SC9B5.08 (468 aa)%2C fasta scores opt: 834 z-score: 888.4 E(): 0 37.1%25 identity in 463 aa overlap. Contains a Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family. Also contains Prosite hits to PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site. gene gene6854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6793 SCO6794 SCO6794 cvnA7 cvnA7 7555369 7557321 + hypothetical protein SC1A2.03%2C cvnA7%2C possible membrane protein%2C len: 650 aa. Weakly similar to several including Streptomyces coelicolor TR:Q9X836(EMBL:AL049727) large hypothetical protein%2C SC9B1.16C (877 aa)%2C fasta scores opt: 781 z-score: 616.3 E(): 6.4e-27 35.1%25 identity in 582 aa overlap and Streptomyces coelicolor TR:CAB61282(EMBL:AL132991) sensor kinase%2C SCF55.12C (575 aa)%2C fasta scores opt: 426 z-score: 343.4 E(): 1e-11 28.9%25 identity in 508 aa overlap. Contains two possible membrane spanning hydrophobic domains towards the N-terminal and 4x VPAPV repeat between residues 485..504. gene gene6855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6794 SCO6795 SCO6795 cvnB7 cvnB7 7557438 7557872 + hypothetical protein SC1A2.04%2C cvnB7%2C unknown%2C len: 124 aa. Highly similar to several proteins of unknown function from Streptomyces coelicolor including: TR:Q9X835(EMBL:AL049727) SC9B1.15C (139 aa)%2C fasta scores opt: 345 z-score: 434.8 E(): 8.2e-17 45.0%25 identity in 140 aa overlap and TR:CAB61281(EMBL:AL132991) SCF55.11C (152 aa)%2C fasta scores opt:309 z-score:390.4 E(): 2.4e-14 41.0%25 identity in 134 aa overlap. gene gene6856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6795 SCO6796 SCO6796 cvnC7 cvnC7 7557869 7558249 + hypothetical protein SC1A2.05%2C cvnC7%2C unknown%2C len: 126 aa. Highly similar to several proteins of unknown function from Streptomyces coelicolor including: TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa)%2C fasta scores opt: 317 z-score: 414.9 E(): 1.1e-15 48.2%25 identity in 114 aa overlap and TR:CAB61280(EMBL:AL132991) SCF55.10C (113 aa)%2C fasta scores opt: 261 z-score: 344.5 E(): 8.8e-12 44.3%25 identity in 106 aa overlap. gene gene6857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6796 SCO6797 SCO6797 cvnD7 cvnD7 7558302 7558856 + ATP/GTP binding protein SC1A2.06%2C cvnD7%2C possible ATP/GTP binding protein%2C len: 184 aa. Highly similar to many Streptomyces coelicolor ATP/GTP binding proteins including: TR:CAA19989(EMBL:AL031124) SC1C2.22C (174 aa)%2C fasta scores opt: 685 z-score: 872.1 E(): 0 60.8%25 identity in 166 aa overlap%2C TR:O86519(EMBL:AL031124) SC1C2.18C (174 aa)%2C fasta scores opt: 686 z-score: 873.4 E(): 0 59.6%25 identity in 166 aa overlap and TR:CAB61279(EMBL:AL132991) SCF55.09C (178 aa)%2Cfasta scores opt: 605 z-score: 771.3 E():0 50.8%25 identity in 177 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6797 SCO6798 SCO6798 SC1A2.07 SC1A2.07 7558853 7559428 + hypothetical protein SC1A2.07%2C unknown%2C len: 191 aa. gene gene6859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6798 SCO6799 SCO6799 tdh tdh 7559630 7560658 + L-threonine 3-dehydrogenase converts threonine and NAD to 1%2C2-amino-3-oxobutanoate and NADH%3B functions in threonine catabolism gene gene6860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6799 SCO6800 SCO6800 kbl kbl 7560698 7561891 + 2-amino-3-ketobutyrate coenzyme A ligase catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine gene gene6861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6800 SCO6801 SCO6801 SC1A2.10 SC1A2.10 7561923 7562825 + LysR family transcriptional regulator SC1A2.10%2C possible LysR-family transcriptional regulator%2C len: 300 aa. Similar to many other regulators e.g. Streptomyces coelicolor TR:CAB62680 (EMBL:AL133422) LysR-family transcriptional regulatory protein%2C SCM1.22C (301 aa)%2C fasta scores opt: 673 z-score: 751.5 E():0 40.3%25 identity in 300 aa overlap. Contains 2x Prosite hits to PS00044 Bacterial regulatory proteins%2C lysR family signature and a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family with the helix-turn-helix motif situated between residues 17..38 (+4.44 SD). gene gene6862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6801 SCO6802 SCO6802 SC1A2.11 SC1A2.11 7562872 7563450 + DNA-binding protein SC1A2.11%2C possible DNA-binding protein%2C len: 192 aa. Similar to Streptomyces coelicolor TR:Q9X7W5 (EMBL:AL049485) DNA-binding protein%2C SC6A5.19 (204 aa)%2C fasta scores opt: 213 z-score: 254.6 E(): 9e-07 30.9%25 identity in 178 aa overlap. Contains a Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix with the helix-turn-helix motif situated between residues 28..49 (+7.43 SD) gene gene6863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6802 SCO6803 SCO6803 SC1A2.12 SC1A2.12 7563447 7563992 + acetyltransferase SC1A2.12%2C possible acetyltransferase%2C len: 181 aa%2C Similar to Pseudomonas syringae (pv. syringae) SW:TTR_PSESY(EMBL:X17150) acetyltransferase (EC 2.3.1.-) involved in resistance to tabtoxin (177 aa)%2C fasta scores opt: 469 z-score: 572.3 E(): 1.8e-24 47.0%25 identity in 168 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene6864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6803 SCO6804 SCO6804 SC1A2.13 SC1A2.13 7563999 7564382 + hypothetical protein SC1A2.13%2C unknown%2C len: 127 aa. gene gene6865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6804 SCO6805 SCO6805 SC1A2.14 SC1A2.14 7564533 7565837 + integral membrane efflux protein SC1A2.14%2C possible integral membrane efflux protein%2C len: 434 aa. Similar to several membrane efflux proteins including: Mycobacterium smegmatis TR:O31137(EMBL:AF030344) Tetracycline-resistance determinant%2C TetV (419 aa)%2C fasta scores opt: 521 z-score: 542.1 E(): 8.7e-23 28.6%25 identity in 406 aa overlap and Streptomyces coelicolor TR:CAB51438(EMBL:AL096884) integral membrane efflux protein%2C SC4G6.15C (384 aa)%2C fasta scores opt: 403 z-score: 421.7 E(): 4.4e-16 30.1%25 identity in 389 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene6866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6805 SCO6806 SCO6806 SC1A2.15C SC1A2.15C 7566130 7567347 - phage integrase SC1A2.15c%2C possible phage integrase%2C len: 405 aa. Weakly similar to Corynephage 304L TR:Q9ZWV7 (EMBL:Y18058) integrase (395 aa)%2C fasta scores opt: 190 z-score: 224.2 E(): 4.4e-05 24.6%25 identity in 391 aa overlap and Streptomyces coelicolor TR:Q9Z4Y1 (EMBL:AL035707) integrase%2C SCE29.19C (384 aa)%2C fasta scores opt: 191 z-score: 225.6 E(): 3.7e-05 27.4%25 identity in 358 aa overlap. Contains a Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. gene gene6868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6806 SCO6807 SCO6807 SC1A2.16c SC1A2.16c 7568251 7570044 - hypothetical protein SC1A2.16c%2C unknown%2C len: 597 aa. gene gene6869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6807 SCO6808 SCO6808 SC1A2.17c SC1A2.17c 7570606 7570968 - transcription regulator ArsR SC1A2.17c%2C possible ArsR-family transcriptional regulator%2C len: 120 aa. Similar to several regulators including: Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) transcriptional regulator%2C SCH35.28C (122 aa)%2C fasta scores opt: 297 z-score: 392.7 E(): 1.8e-14 49.4%25 identity in 87 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) transcriptional regulator (126 aa)%2C fasta scores opt: 262 z-score: 348.0 E(): 5.6e-12 38.1%25 identity in 113 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family with the helix-turn-helix motif situated between residues 56..77 (+4.54 SD). gene gene6870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6808 SCO6809 SCO6809 SC1A2.18c SC1A2.18c 7571107 7572336 - integral membrane transport protein SC1A2.18c%2C possible integral membrane transport protein%2C len: 409 aa. Similar to several membrane transport proteins e.g. Listeria monocytogenes TR:Q9X769 (EMBL:AJ009627) multi drug resistance transporter (397 aa)%2C fasta scores opt: 241 z-score: 264.5 E(): 2.5e-07 23.0%25 identity in 344 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Prosite hit to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene6871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6809 SCO6810 SCO6810 SC1A2.19c SC1A2.19c 7572343 7572801 - hypothetical protein SC1A2.19c%2C unknown%2C len: 152 aa. Highly similar to proteins of undefined function from Mycobacterium tuberculosis SW:YQ11_MYCTU (EMBL:Z80225) (152 aa)%2C fasta scores opt: 509 z-score: 630.7 E(): 1e-27 55.0%25 identity in 149 aa overlap and Bacillus subtilis SW:YQCK_BACSU (EMBL:D32216) (146 aa)%2C fasta scores opt:349 z-score: 437.2 E():6e-17 34.9%25 identity in 152 aa overlap gene gene6872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6810 SCO6811 SCO6811 SC1A2.20c SC1A2.20c 7572869 7574263 - hypothetical protein SC1A2.20c%2C possible hypothetical protein%2C len: 464 aa. The N-terminus is highly similar to Streptomyces coelicolor TR:Q9X8X7 (EMBL:AL078610) hypothetical protein%2C SCH35.29 (162 aa)%2C fasta scores opt: 753 z-score: 813.4 E(): 0 71.2%25 identity in 146 aa overlap. Contains a possible N-terminal signal sequence. gene gene6873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6811 SCO6812 SCO6812 SC1A2.21 SC1A2.21 7574420 7574779 + transcription regulator ArsR SC1A2.21%2C possible ArsR-family transcriptional regulator%2C len: 119 aa. Highly similar to several including: Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) transcriptional regulator%2C SCH35.28C (122 aa)%2C fasta scores opt: 485 z-score: 630.1 E(): 1.1e-27 69.7%25 identity in 99 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) transcriptional regulator (126 aa)%2C fasta scores opt:378 z-score: 494.4 E(): 3.9e-20 59.8%25 identity in 97 aa overlap. Also similar to the adjoining CDS SC1A2.22 (113 aa)%2C fasta scores opt: 292 z-score: 353.0 E(): 3.1e-14 51.1%25 identity in 94 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene6874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6812 SCO6813 SCO6813 SC1A2.22 SC1A2.22 7574897 7575238 + transcription regulator ArsR SC1A2.22%2C possible ArsR-family transcriptional regulator%2C len: 129 aa. Highly similar to several including: Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) transcriptional regulator%2C SCH35.28C (122 aa)%2C fasta scores opt: 271 z-score: 365.4 E(): 6e-13 50.0%25 identity in 92 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) transcriptional regulator (126 aa)%2C fasta scores opt: 214 z-score: 291.6 E(): 7.7e-09 59.4%25 identity in 64 aa overlap. Also similar to the adjoining CDS SC1A2.21 (119 aa)%2C fasta scores opt: 292 z-score: 353.0 E(): 3.1e-14 51.1%25 identity in 94 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene6875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6813 SCO6814 SCO6814 SC1A2.23c SC1A2.23c 7575359 7576030 - ABC transporter ATP-binding protein SC1A2.23c%2C possible ABC transporter ATP-binding component%2C len: 223 aa. Similar to many ABC transporters including: Deinococcus radiodurans TR:AAF12204 (EMBL:AE001862) phosphate ABC transporter%2C ATP-binding protein (254 aa)%2C fasta scores opt: 458 z-score: 524.0 E(): 8.7e-22 38.1%25 identity in 210 aa overlap and Escherichia coli SW:PSTB_ECOLI (EMBL:X02723) phosphate ABC transporter%2C ATP-binding protein%2C PstB(257 aa)%2C fasta scores opt: 436 z-score: 499.3 E(): 2.1e-20 38.9%25 identity in 198 aa overlap. Contains Prosite hits to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene6876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6814 SCO6815 SCO6815 SC1A2.24c SC1A2.24c 7576036 7577847 - ABC transporter permease SC1A2.24c%2C bi-domain ABC transporter permease%2C len: 603 aa. The N-terminus and C-terminus appear to be discrete domains%2C both of which are similar to many ABC transporter permeases e.g. The N-terminus is similar to Methanobacterium thermoautotrophicum TR:O27762 (EMBL:AE000929) phosphate transporter permease (291 aa)%2C fasta scores opt: 467 z-score: 511.4 E(): 4.5e-21 32.5%25 identity in 268 aa overlap. The C-terminal is similar to Escherichia coli SW:PSTA_ECOLI (EMBL:X02723) phosphate transport system permease%2C PstA (296 aa)%2C fasta scores opt: 396 z-score: 434.6 E(): 8.4e-17 30.1%25 identity in 286 aa overlap. Contains 2x Prosite hits to PS00402 Binding-protein-dependent transport systems inner membrane comp sign and 2x Pfam matches to entries PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Contains multiple possible membrane spanning hydrophobic domains. gene gene6877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6815 SCO6816 SCO6816 SC1A2.25c SC1A2.25c 7577851 7578723 - ABC transporter binding lipoprotein SC1A2.25c%2C possible ABC transporter binding lipoprotein%2C len: 290 aa. Similar to several including: Escherichia coli SW:PSTS_ECOLI (EMBL:K01992) phosphate-binding protein precursor (346 aa)%2C fasta scores opt: 158 z-score: 176.7 E(): 0.019 25.9%25 identity in 259 aa overlap and Methanobacterium thermoautotrophicum TR:O27760 (EMBL:AE000929) phosphate-binding protein%2C PstS (271 aa)%2C fasta scores opt: 510 z-score: 554.5 E(): 1.8e-23 34.9%25 identity in 281 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site%2C a Pfam match to entry PF01449 PstS%2C Phosphate-binding protein and a possible N-terminal signal sequence. gene gene6878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6816 SCO6817 SCO6817 SC1A2.26c SC1A2.26c 7579044 7579403 - hypothetical protein SC1A2.26c%2C unknown%2C len: 119 aa. gene gene6879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6817 SCO6818 SCO6818 SC1A2.27c. SC1A2.27c. 7579400 7580935 - 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gene gene6880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6818 SCO6819 SCO6819 aroA aroA 7580932 7582254 - 3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis gene gene6881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6819 SCO6820 SCO6820 SC1A2.29c SC1A2.29c 7582309 7584639 - oxidoreductase SC1A2.29c%2C possible oxidoreductase%2C len: 776 aa. Similar to a number of formate dehydrogenases e.g. Escherichia coli SW:FDHF_ECOLI(EMBL:M13563) formate dehydrogenase H (EC 1.2.1.2) (715 aa)%2C fasta scores opt: 503 z-score: 564.0 E(): 5.2e-24 29.4%25 identity in 799 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding%2C Molydopterin dinucleotide binding domain. gene gene6882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6820 SCO6821 SCO6821 SC1A2.30c SC1A2.30c 7584942 7585664 - hypothetical protein SC1A2.30c%2C possible transferase%2C len: 240 aa. Weakly similar to the C-terminal glutamine amide transferase domain of several CTP synthases e.g. Escherichia coli SW:PYRG_ECOLI(EMBL:M12843) CTP synthase (EC 6.3.4.2) (544 aa)%2C fasta scores opt: 184 z-score: 227.2 E(): 3e-05 24.4%25 identity in 225 aa overlap. gene gene6883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6821 SCO6822 SCO6822 SC1A2.31 SC1A2.31 7586410 7587975 + integral membrane efflux protein SC1A2.31%2C possible integral membrane efflux protein%2C len: 521 aa. Highly similar to many members of the drug resistance translocase family including: Streptomyces virginiae TR:Q9XE01 (EMBL:AB019519) virginiamycin S resistance protein%2C VarS (518 aa)%2C fasta scores opt: 1230 z-score: 1294.4 E():0 40.7%25 identity in 523 aa overlap and Streptomyces coelicolor TR:Q9Z563 (EMBL:AL035569) integral membrane efflux protein%2C SC8D9.28C (521 aa)%2C fasta scores opt: 1072 z-score: 1128.8 E():0 37.7%25 identity in 515 aa overlap. Contains a Prosite hit to PS00216 Sugar transport proteins signature 1 and a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. Also contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. gene gene6884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6822 SCO6823 SCO6823 SC1A2.32 SC1A2.32 7587993 7588445 + transcription regulator ArsR SC1A2.32%2C possible ArsR-family transcriptional regulator%2C len: 150 aa. Similar to several including: Sinorhizobium sp. As4 TR:AAD51845 (EMBL:AF178758) ArsR regulatory protein (115 aa)%2C fasta scores opt: 129 z-score: 168.5 E(): 0.056 29.1%25 identity in 103 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family with a helix-turn-helix motif situated between residues 68..89 (+3.74 SD). gene gene6885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6823 SCO6824 SCO6824 SC1A2.33c SC1A2.33c 7588532 7589635 - phosphonopyruvate decarboxylase (fragment) SC4A9.01c%2C possible phosphonopyruvate decarboxylase%2C partial CDS%2C len: >32 aa. Highly similar to Streptomyces coelicolor TR:Q9XBE9(EMBL:AL078635) phosphonopyruvate decarboxylase%2C CZA382.02 (371 aa)%2C fasta scores opt:95 z-score: 160.0 E():0.17 51.7%25 identity in 29 aa overlap. Overlaps and extends into CDS SC1A2.33c on the adjoining cosmid.~SC1A2.33c%2C possible phosphonopyruvate decarboxylase%2C partial CDS%2C len: >366 aa. Highly similar to several including: Streptomyces wedmorensis TR:Q56190(EMBL:AB016934) phosphonopyruvate decarboxylase (384 aa)%2C fasta scores opt: 391 z-score: 431.7 E(): 1.2e-16 37.8%25 identity in 347 aa overlap and Streptomyces coelicolor TR:Q9XBE9(EMBL:AL078635) phosphonopyruvate decarboxylase%2C CZA382.02 (371 aa)%2C fasta scores opt: 1134 z-score: 1240.1 E(): 0 49.2%25 identity in 366 aa overlap. Contains a Prosite hit to PS00187 Thiamine pyrophosphate enzymes signature. gene gene6886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6824 SCO6825 SCO6825 SC4A9.02c SC4A9.02c 7589632 7590327 - hypothetical protein SC4A9.02c%2C possible integral membrane protein%2C len: 231 aa. Highly to several proteins of undefined function including Escherichia coli SW:DEDA_ECOLI (EMBL:M68934) DedA hypothetical protein found in the hisT-purF region (219 aa)%2C fasta scores opt: 550 z-score: 642.2 E(): 2.3e-28 43.8%25 identity in 185 aa overlap and Streptomyces coelicolor TR:Q9X8J1 (EMBL:AL049841) possible membrane protein%2C SCE9.18c (303 aa)%2C fasta scores opt: 812 z-score: 940.8 E():0 53.7%25 identity in 227 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Pfam match to entry PF00597 DedA%2C DedA family. gene gene6887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6825 SCO6826 SCO6826 SC4A9.03c SC4A9.03c 7590412 7591452 - hypothetical protein SC4A9.03c%2C unknown%2C len: 346 aa. Similar to a protein of undefined function encoded within the Streptomyces peucetius daunorubicin-doxorubicin polyketide synthase gene cluster: TR:Q54816 (EMBL:L35560) DpsC (353 aa)%2C opt: 662 z-score: 779.9 E(): 0 36.0%25 identity in 344 aa overlap. Also similar to Streptomyces sp. TR:Q55225 (EMBL:L34880) OrfC%2C a beta-keto acyl synthase III homologue (352 aa)%2C fasta scores opt: 599 z-score: 706.2 E(): 6.3e-32 33.4%25 identity in 341 aa overlap gene gene6888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6826 SCO6827 SCO6827 SC4A9.04c SC4A9.04c 7591479 7598555 - polyketide synthase SC4A9.04c%2C polyketide synthase%2C len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase%2C MtAE%2C found within the Myxothiazol biosynthetic gene cluster (1947 aa)%2C fasta scores opt: 2671 z-score: 2436.5 E():0 35.8%25 identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene%2C PpsA (1876 aa)%2C fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6%25 identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 Phosphopantetheine attachment site. Also contains Pfam matches to entries PF00109 ketoacyl-synt%2C Beta-ketoacyl synthase%2C PF00698 Acyl_transf%2C Acyl transferase domain%2C PF00107 adh_zinc%2C Zinc-binding dehydrogenases and 2xPF00550 pp-binding%2C Phosphopantetheine attachment site. The 72 amino acids%2C 2139..2210%2C are perfectly repeated between residues 2280..2351 in the C-terminus of this protein. gene gene6889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6827 SCO6828 SCO6828 SC4A9.05 SC4A9.05 7599249 7600730 + hypothetical protein SC4A9.05%2C possible hypothetical protein%2C len: 493 aa. Highly similar to Streptomyces coelicolor hypothetical protein SC1A2.20c (464 aa)%2C fasta scores opt: 1389 z-score: 1246.8 E():0 51.0%25 identity in 455 aa overlap. Also weakly similar to Streptomyces coelicolor TR:CAB52349(EMBL:AL109747) flavin-containing monooxygenase (458 aa)%2C fasta scores opt: 151 z-score: 166.3 E(): 0.075 24.2%25 identity in 414 aa overlap. Contains a possible N-terminal signal sequence. gene gene6890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6828 SCO6829 SCO6829 SC4A9.06c SC4A9.06c 7600790 7601569 - oxidoreductase SC4A9.06c%2C possible oxidoreductase%2C len: 259 aa. Highly similar to Streptomyces coelicolor TR:Q9X890(EMBL:AL049707) oxidoreductase%2C SCE15.15 (260 aa)%2C fasta scores opt: 1088 z-score: 1221.9 E(): 0 66.9%25 identity in 254 aa overlap. Also similar to Streptomyces griseus subsp. griseus TR:Q9XDF5(EMBL:AF074603) ketoacyl reductase (271 aa)%2C fasta scores opt: 421 z-score: 479.1 E(): 2.8e-19 36.7%25 identity in 256 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene6891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6829 SCO6830 SCO6830 SC4A9.07 SC4A9.07 7601654 7602007 + transcription regulator ArsR SC4A9.07%2C possible ArsR-family transcriptional regulator%2C len: 117 aa. Highly similar to Streptomyces coelicolor TR:Q9X8X8 (EMBL:AL078610) transcriptional regulator SCH35.28C (122 aa)%2C fasta scores opt: 561 z-score: 746.6 E():0 78.0%25 identity in 109 aa overlap and Mycobacterium tuberculosis TR:P71941 (EMBL:Z80225) transcriptional regulator (126 aa)%2C fasta scores opt: 359 z-score: 482.6 E(): 1.8e-19 56.9%25 identity in 116 aa overlap. Also similar to several other Streptomyces coelicolor ArsR-family transcriptional regulators including: SC1A2.21 (119 aa)%2C fasta scores opt: 491 z-score: 582.6 E(): 5.2e-27 64.7%25 identity in 116 aa overlap and SC1A2.17c (120 aa)%2C fasta scores opt: 295 z-score: 356.1 E(): 2.1e-14 45.5%25 identity in 99 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene6892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6830 SCO6831 SCO6831 SC4A9.08 SC4A9.08 7602498 7602773 + hypothetical protein SC4A9.08%2C unknown%2C len: 91 aa. gene gene6893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6831 SCO6832 SCO6832 mutA mutA 7602829 7604424 + methylmalonyll-CoA mutase SC4A9.09%2C mutA%2C methylmalonyl-CoA mutase (EC 5.4.99.2)%2C len: 531 aa. Highly similar to many members of the methylmalonyll-CoA mutase family including: Sinorhizobium meliloti TR:O86028(EMBL:AF080073) methylmalonyll-CoA mutase (EC 5.4.99.2) (712 aa)%2C fasta scores opt: 1720 z-score: 1946.7 E(): 0 52.2%25 identity in 515 aa overlap and Pyrococcus abyssi TR:CAB49756(EMBL:AJ248285) methylmalonyl-CoA mutase%2C subunit alpha%2C N-terminus (562 aa)%2C fasta scores opt: 2180 z-score: 2469.0 E():0 62.7%25 identity in 518 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X949(EMBL:AJ237976) isobutyryl-CoA mutase A (EC 5.4.99.13)%2C SC8F4.19 (566 aa)%2C fasta scores opt: 1515 z-score: 1556.8 E():0 50.5%25 identity in 541 aa overlap. Contains a Pfam match to entry PF01642 MM_CoA_mutase%2C Methylmalonyl-CoA mutase. gene gene6894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6832 SCO6833 SCO6833 SC3D9.01 SC3D9.01 7604468 7604947 + isobutyryl-CoA mutase%2C small subunit SC3D9.01%2C probable isobutyryl-CoA mutase%2C small subunit (EC 5.4.99.13)%2C len: 159 aa. Highly similar to Streptomyces cinnamonensis TR:CAB59633 (EMBL:AJ246005) isobutyryl-CoA mutase%2C small subunit (EC 5.4.99.13) (136 aa)%2C fasta scores opt: 580 z-score: 685.3 E(): 9.2e-31 68.3%25 identity in 126 aa overlap and to the C-terminus of Streptomyces cinnamonensis SW:MUTB_STRCM (EMBL:L10064) methylmalonyl-CoA mutase alpha-subunit (EC 5.4.99.2) (733 aa)%2C fasta scores opt: 291 z-score: 341.2 E(): 1.4e-11 40.5%25 identity in 111 aa overlap. gene gene6895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6833 SCO6834 SCO6834 trxB2 trxB2 7605261 7606241 - thioredoxin reductase SC3D9.02c%2C trxB2%2C possible thioredoxin reductase (326 aa). Previously sequenced and consequently identical to Streptomyces coelicolor TR:CAB61258 (EMBL:AJ251005). Also highly similar to the other Streptomyces coelicolor trxB CDS: SW:TRXB_STRCO( EMBL:X92105) thioredoxin reductase (EC 1.6.4.5) SCH24.12 (321 aa)%2C fasta scores opt: 1547 z-score: 1709.6 E():0 74.2%25 identity in 310 aa overlap. Contains a Prosite hit to PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. gene gene6896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6834 SCO6835 SCO6835 arsC arsC 7606238 7606651 - arsenate reductase SC3D9.03c%2C arsC%2C possible arsenate reductase%2C len: 137 aa. Previously sequenced and consequently identical to Streptomyces coelicolor TR:CAB61257(EMBL:AJ251005). Also highly similar to Streptomyces coelicolor TR:Q9X8Y2(EMBL:AL078610) heavy metal reductase%2C SCH35.24C (137 aa)%2C fasta scores opt: 863 z-score: 986.3 E(): 0 92.7%25 identity in 137 aa overlap. Contains a Pfam match to entry PF01451 LMWPc%2C Low molecular weight phosphotyrosine protein phosphatase. gene gene6897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6835 SCO6836 SCO6836 arsR arsR 7606744 7607052 + transcription regulator ArsR SC3D9.04%2C arsR%2C possible ArsR-family transcriptional regulator%2C len: 102 aa. Previously partially sequenced and consequently identical to Streptomyces coelicolor TR:CAB61256 (EMBL:AJ251005) transcriptional regulator (fragment) (>93 aa). Also highly similar to Streptomyces coelicolor TR:Q9X8Y1(EMBL:AL078610) transcriptional regulator%2C SCH35.25 (102 aa)%2C fasta scores opt: 617 z-score: 838.5 E(): 0 95.1%25 identity in 102 aa overlap. Contains a Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family. gene gene6898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6836 SCO6837 SCO6837 SC3D9.05 SC3D9.05 7607049 7608155 + arsenic resistance membrane transport protein SC3D9.05%2C possible arsenic resistance membrane transport protein%2C len: 368 aa. Highly similar to Streptomyces coelicolor TR:Q9X8Y0(EMBL:AL078610) heavy metal resistance membrane protein%2C SCH35.26 (369 aa)%2C fasta scores opt: 2304 z-score: 2675.9 E(): 0 95.4%25 identity in 369 aa overlap and Sinorhizobium sp. As4. TR:AAD51846(EMBL:AF178758) membrane subunit of arsenic oxyanion-translocation pump%2C ArsB (351 aa)%2C fasta scores opt: 1263 z-score: 1469.8 E():0 53.8%25 identity in 344 aa overlap. Contains possible membrane spanning hydrophobic domains and a Pfam match to entry PF01758 SBF%2C Sodium Bile acid symporter family. gene gene6899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6837 SCO6838 SCO6838 SC3D9.06 SC3D9.06 7608214 7609278 + monooxygenase SC3D9.06%2C possible monooxygenase%2C len: 354 aa. Highly similar to Streptomyces coelicolor TR:Q9X8X9(EMBL:AL078610) oxidoreductase%2C SCH35.27 (406 aa)%2C fasta scores opt: 1377 z-score: 1503.9 E():0 66.7%25 identity in 327 aa overlap. Also similar to Streptomyces coelicolor TR:CAB59668(EMBL:AL132674) monooxygenase%2C SCE87.23C (519 aa)%2C fasta scores opt: 355 z-score: 390.5 E(): 2.4e-14 28.6%25 identity in 371 aa overlap. Contains a Pfam match to entry PF00743 FMO-like%2C Flavin-binding monooxygenase-like. gene gene6900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6838 SCO6839 SCO6839 SC3D9.07c SC3D9.07c 7609452 7610765 - hypothetical protein SC3D9.07c%2C unknown%2C len: 437 aa. gene gene6901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6839 SCO6840 SCO6840 SC3D9.08c SC3D9.08c 7610762 7612807 - hypothetical protein SC3D9.08c%2C unknown%2C len: 681 aa. gene gene6902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6840 SCO6841 SCO6841 SC3D9.09 SC3D9.09 7613335 7614387 + hypothetical protein SC3D9.09%2C unknown%2C len: 350 aa. Similar to Streptomyces coelicolor TR:Q9X865 (EMBL:AL049661) hypothetical protein SCE134.10 (320 aa)%2C fasta scores opt: 589 z-score: 714.3 E(): 2.2e-32 46.0%25 identity in 313 aa overlap gene gene6903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6841 SCO6842 SCO6842 SC3D9.10c SC3D9.10c 7614564 7615928 - hypothetical protein SC3D9.10c%2C unknown%2C len: 454 aa. gene gene6904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6842 SCO6843 SCO6843 SC3D9.11c SC3D9.11c 7615994 7617112 - hypothetical protein SC3D9.11c%2C unknown%2C len: 372 aa. Weakly similar to Streptomyces coelicolor TR:Q9X8A4 (EMBL:AL049645) hypothetical protein%2C SCE2.09 (386 aa)%2C fasta scores opt: 559 z-score: 616.2 E(): 6.5e-27%3B 37.5%25 identity in 363 aa overlap gene gene6905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6843 SCO6844 SCO6844 SC3D9.12c SC3D9.12c 7617112 7618383 - DNA methylase SC3D9.12c%2C possible DNA methylase%2C len: 423 aa. Weakly similar to Salmonella infantis SW:MTSI_SALIN(EMBL:J03391) modification methylase%2C SinI (EC 2.1.1.73) (461 aa)%2C fasta scores opt: 244 z-score: 269.9 E(): 1.3e-07 24.5%25 identity in 355 aa overlap. Contains 2xPfam matches to entries PF00145 DNA_methylase%2C C-5 cytosine-specific DNA methylase. gene gene6906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6844 SCO6845 SCO6845 SC3D9.13c SC3D9.13c 7618380 7619000 - hypothetical protein SC3D9.13c%2C unknown%2C len: 206 aa. Similar in parts to Agrobacterium tumefaciens (Ti plasmid pTiC58) TR:BAA87688 (EMBL:AB016260) hypothetical protein%2C TiOrf63 (312 aa)%2C fasta scores opt: 466 z-score: 575.5 E(): 1.2e-24 44.3%25 identity in 167 aa overlap. gene gene6907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6845 SCO6846 SCO6846 SC3D9.14c SC3D9.14c 7619557 7619880 - hypothetical protein SC3D9.14c%2C unknown%2C len: 107 aa. gene gene6908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6846 SCO6847 SCO6847 SC3D9.15c SC3D9.15c 7620290 7620910 - hypothetical protein SC3D9.15c%2C unknown%2C len: 206 aa. Contains a 24 amino acid direct repeat (ATYRTVSRRLSRRLASFSARAEDR) between residues 129..152 and 154..177. gene gene6909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6847 SCO6848 SCO6848 SC3D9.16c SC3D9.16c 7621003 7621461 - hypothetical protein SC3D9.16c%2C unknown%2C len: 152 aa%3B similar to TR:Q9PCL6 (EMBL:AE003998) Xylella fastidiosa hypothetical protein XF1762%2C 172 aa%3B fasta scores: opt: 501 Z-score: 598.8 E(): 1e-25%3B 55.484%25 identity in 155 aa overlap gene gene6910 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6848 SCO6849 SCO6849 SC3D9.17c SC3D9.17c 7621458 7623185 - hypothetical protein SC7F9.01c%2C possible membrane protein%2C partial CDS%2C len: > 373 aa. Highly similar to Streptomyces coelicolor TR:Q9X8A2(EMBL:AL049645) hypothetical 45.0 KD protein%2C SCE2.07 (427 aa)%2C fasta scores opt: 1024 z-score: 1198.6 E():0 68.8%25 identity in 224 aa overlap. Contains a possible membrane spanning hydrophobic domain.~SC3D9.17c%2C unknown%2C partial CDS%2C len:> 235 aa. Highly similar to Streptomyces coelicolor TR:Q9X8A2(EMBL:AL049645) hypothetical protein%2C SCE2.07 (427 aa)%2C fasta scores opt: 1120 z-score: 1326.9 E():0 71.8%25 identity in 234 aa overlap. gene gene6911 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6849 SCO6850 SCO6850 SC7F9.02c SC7F9.02c 7623285 7624064 - hypothetical protein SC7F9.02c%2C unknown%2C len: 259 aa. Similar to other hypothetical proteins predicted to be encoded by CDS located on this cosmid: SC7F9.04c (273 aa)%2C fasta scores opt: 442 z-score: 398.4 E(): 9.8e-17 33.7%25 identity in 255 aa overlap and SC7F9.06c (267 aa)%2C fasta scores opt: 385 z-score: 348.6 E(): 5.8e-14 34.6%25 identity in 257 aa overlap gene gene6912 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6850 SCO6851 SCO6851 SC7F9.03c SC7F9.03c 7624067 7624633 - hypothetical protein SC7F9.03c%2C unknown%2C len: 188 aa. Weakly similar to Streptomyces coelicolor TR:Q9X874 (EMBL:AL049661) hypothetical protein%2C SCE134.19 (211 aa)%2C fasta scores opt: 124 z-score: 162.0 E(): 0.13 24.0%25 identity in 150 aa overlap. gene gene6913 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6851 SCO6852 SCO6852 SC7F9.04c SC7F9.04c 7624664 7625485 - hypothetical protein SC7F9.04c%2C unknown%2C len: 273 aa. Similar to other hypothetical proteins predicted to be encoded by CDS located on this cosmid: SC7F9.02c (259 aa)%2C fasta scores opt: 442 z-score: 398.4 E(): 9.8e-17 33.7%25 identity in 255 aa overlap and SC7F9.06c (267 aa)%2C fasta scores opt: 76 z-score: 373.8 E(): 2.3e-15 30.5%25 identity in 272 aa overlap gene gene6914 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6852 SCO6853 SCO6853 SC7F9.05 SC7F9.05 7625557 7625841 + hypothetical protein SC7F9.05%2C unknown%2C len: 94 aa. gene gene6915 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6853 SCO6854 SCO6854 SC7F9.06c SC7F9.06c 7625857 7626660 - hypothetical protein SC7F9.06c%2C unknown%2C len: 267 aa. Similar to other hypothetical proteins predicted to be encoded by CDS located on this cosmid: SC7F9.02c (259 aa)%2C fasta scores opt: 385 z-score: 396.2 E(): 1.3e-16 34.6%25 identity in 257 aa overlap and SC7F9.04c (273 aa)%2C fasta scores opt: 376 z-score: 386.8 E(): 4.3e-16 30.5%25 identity in 272 aa overlap. gene gene6916 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6854 SCO6855 SCO6855 SC7F9.07c SC7F9.07c 7626657 7627040 - hypothetical protein SC7F9.07c%2C unknown%2C len: 127 aa. Weakly similar to SC7F9.08c hypothetical protein%2C also located on this cosmid (215 aa)%2C fasta scores opt:98 z-score: 114.2 E(): 0.66 28.9%25 identity in 121 aa overlap. gene gene6917 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6855 SCO6856 SCO6856 SC7F9.08c SC7F9.08c 7627477 7628124 - hypothetical protein SC7F9.08c%2C unknown%2C len: 215 aa. Weakly similar to Streptomyces coelicolor TR:Q9X899 (EMBL:AL049645) hypothetical 25.5 KD protein%2C SCE2.04 (241 aa)%2C fasta scores opt: 158 z-score: 178.7 E():0.015 28.0%25 identity in 150 aa overlap. gene gene6918 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6856 SCO6857 SCO6857 SC7F9.09c SC7F9.09c 7628121 7628879 - hypothetical protein SC7F9.09c%2C unknown%2C len: 252 aa. gene gene6919 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6857 SCO6858 SCO6858 SC7F9.10c SC7F9.10c 7628905 7629609 - hypothetical protein SC7F9.10c%2C unknown%2C len: 215 aa. Weakly similar to Streptomyces coelicolor TR:Q9X899 (EMBL:AL049645) hypothetical 25.5 KD protein%2C SCE2.04 (241 aa)%2C fasta scores opt: 160 z-score: 176.7 E(): 0.02 28.3%25 identity in 205 aa overlap. gene gene6920 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6858 SCO6859 SCO6859 SC7F9.11c SC7F9.11c 7629623 7630453 - hypothetical protein SC7F9.11c%2C unknown%2C len: 276 aa. gene gene6921 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6859 SCO6860 SCO6860 SC7F9.12c SC7F9.12c 7630450 7630887 - hypothetical protein SC7F9.12c%2C unknown%2C len: 145 aa. gene gene6922 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6860 SCO6861 SCO6861 pk3 pk3 7631006 7632703 - protein kinase-like protein SC7F9.13c%2C pk3%2C protein kinase-like protein%2C 565 aa. Previously sequenced therefore identical to Streptomyces coelicolor TR:Q53839(EMBL:U19250). Contains Prosite hits to PS00107 Protein kinases ATP-binding region signature and PS00108 Ser/Thr protein kinases active-site signature. Also contains a Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain. gene gene6923 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6861 SCO6862 SCO6862 SC7F9.14c SC7F9.14c 7632712 7633056 - hypothetical protein SC7F9.14c%2C unknown%2C len: 114 aa. gene gene6924 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6862 SCO6863 SCO6863 SC7F9.15c SC7F9.15c 7633190 7633819 - hypothetical protein SC7F9.15c%2C unknown%2C len: 209 aa. gene gene6925 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6863 SCO6864 SCO6864 SC7F9.16c SC7F9.16c 7633888 7635678 - hypothetical protein SC7F9.16c%2C unknown%2C len: 596 aa. Rich in the amino acid Ala. gene gene6926 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6864 SCO6865 SCO6865 SC7F9.17c SC7F9.17c 7635675 7636883 - regulatory protein SC7F9.17c%2C possible regulatory protein%2C len: 402 aa. Weakly similar to a number of transcriptional regulatory proteins e.g. Pseudomonas stutzeri SW:NIRQ_PSEST (EMBL:Z17423) denitrification regulatory protein%2C NirQ (275 aa)%2C fasta scores opt: 263 z-score: 268.0 E(): 1.6e-07 31.8%25 identity in 217 aa overlap. Contains a helix-turn-helix motif situated between residues 34..55 (+3.07 SD) and a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6927 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6865 SCO6866 SCO6866 SC7F9.18c SC7F9.18c 7637267 7638457 - hypothetical protein SC7F9.18c%2C unknown%2C len: 396 aa. Weakly similar to Deinococcus radiodurans TR:AAF11162 (EMBL:AE002004) conserved hypothetical protein (470 aa)%2C fasta scores opt: 145 z-score: 156.5 E():0.26 25.1%25 identity in 407 aa overlap. gene gene6928 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6866 SCO6867 SCO6867 SC7F9.19c SC7F9.19c 7638454 7638912 - hypothetical protein SC7F9.19c%2C unknown%2C len: 152 aa. Similar to the N-terminus of Streptomyces coelicolor TR:Q9X896 (EMBL:AL049645) hypothetical 26.6 KD protein%2C SCE2.01 (254 aa)%2C fasta scores opt: 203 z-score: 219.9 E(): 7.7e-05 42.0%25 identity in 81 aa overlap. gene gene6929 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6867 SCO6868 SCO6868 SC7F9.20c SC7F9.20c 7638950 7640056 - hypothetical protein SC7F9.20c%2C unknown%2C len: 368 aa. gene gene6930 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6868 SCO6869 SCO6869 SC7F9.21c SC7F9.21c 7640049 7640792 - hypothetical protein SC7F9.21c%2C unknown%2C len: 247 aa. gene gene6931 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6869 SCO6870 SCO6870 SC7F9.22c SC7F9.22c 7640844 7641461 - hypothetical protein SC7F9.22c%2C unknown%2C len: 205 aa. gene gene6932 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6870 SCO6871 SCO6871 SC7F9.23c SC7F9.23c 7641501 7642568 - lipoprotein SC7F9.23c%2C possible lipoprotein%2C len: 355 aa. Weakly similar to Streptomyces coelicolor TR:CAB61724(EMBL:AL133220) hypothetical 31.7 KD protein%2C SCC75A.24 (295 aa)%2C fasta scores opt: 316 z-score: 356.8 E(): 1.8e-12 27.3%25 identity in 297 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene6933 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6871 SCO6872 SCO6872 SC7F9.24c SC7F9.24c 7642591 7643502 - hypothetical protein SC7F9.24c%2C unknown%2C len: 303 aa. Similar in parts to Streptomyces coelicolor TR:Q9X875(EMBL:AL049661) hypothetical 21.6 KD protein%2C SCE134.20 (203 aa)%2C fasta scores opt: 358 z-score: 349.8 E(): 4.5e-12 43.8%25 identity in 146 aa overlap. gene gene6934 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6872 SCO6873 SCO6873 SC7F9.25c SC7F9.25c 7643492 7643734 - hypothetical protein SC7F9.25c%2C unknown%2C len: 80 aa. gene gene6935 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6873 SCO6874 SCO6874 SC7F9.26c SC7F9.26c 7643807 7644442 - hypothetical protein SC7F9.26c%2C unknown%2C len: 211 aa. gene gene6936 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6874 SCO6875 SCO6875 SC7F9.27c SC7F9.27c 7644396 7644821 - hypothetical protein SC7F9.27c%2C unknown%2C len: 141 aa. gene gene6937 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6875 SCO6876 SCO6876 SC7F9.28c SC7F9.28c 7644900 7645406 - hypothetical protein SC7F9.28c%2C unknown%2C len: 168 aa. gene gene6938 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6876 SCO6877 SCO6877 SC7F9.29c SC7F9.29c 7645403 7646185 - hypothetical protein SC7F9.29c%2C unknown%2C len: 260 aa. gene gene6939 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6877 SCO6878 SCO6878 SC7F9.30c SC7F9.30c 7646264 7647787 - ATP-binding protein SC7F9.30c%2C possible ATP-binding protein%2C len: 507 aa. Highly similar to Streptomyces coelicolor TR:Q9X873(EMBL:AL049661) ATP-binding protein%2C SCE134.18 (489 aa)%2C fasta scores opt: 2405 z-score: 2548.3 E(): 0 73.5%25 identity in 490 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene6940 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6878 SCO6879 SCO6879 SC7F9.31c SC7F9.31c 7647816 7648277 - hypothetical protein SC7F9.31c%2C hypothetical protein%2C len: 153 aa. Similar to Streptomyces coelicolor TR:Q9X872(EMBL:AL049661) hypothetical 16.3 KD protein%2C SCE134.17 (150 aa)%2C fasta scores opt:309 z-score: 375.4 E(): 1.7e-13 38.6%25 identity in 153 aa overlap. gene gene6941 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6879 SCO6880 SCO6880 SC7F9.32c SC7F9.32c 7648378 7649820 - lipoprotein SC7F9.32c%2C possible lipoprotein%2C len: 480 aa. Highly similar to Streptomyces coelicolor TR:Q9X871(EMBL:AL049661) integral membrane protein%2C SCE134.16 (488 aa)%2C fasta scores opt: 2046 z-score: 2266.5 E(): 0 63.3%25 identity in 479 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene6942 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6880 SCO6881 SCO6881 SC7F9.33c SC7F9.33c 7649943 7651331 - ATP-binding protein SC7F9.33c%2C possible ATP-binding protein%2C len: 462 aa. Highly similar to Streptomyces coelicolor TR:Q9X870(EMBL:AL049661) ATP-binding protein%2C SCE134.15 (469 aa)%2C fasta scores opt: 1469 z-score: 1094.9 E():0 52.2%25 identity in 490 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible membrane spanning hydrophobic domains. gene gene6943 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6881 SCO6882 SCO6882 SC7F9.34c SC7F9.34c 7651368 7652060 - hypothetical protein SC7F9.34c%2C possible membrane protein%2C len: 230 aa. Highly similar to Streptomyces coelicolor TR:Q9X869(EMBL:AL049661) hypothetical protein%2C SCE134.14 (226 aa)%2C fasta scores opt: 694 z-score: 716.2 E(): 1.8e-32 51.1%25 identity in 223 aa overlap. Contains a possible membrane spanning hydrophobic domain in the N-terminus. gene gene6944 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6882 SCO6883 SCO6883 SC7F9.35c SC7F9.35c 7652060 7652374 - hypothetical protein SC7F9.35c%2C possible membrane protein%2C len: 104 aa. Highly similar to Streptomyces coelicolor TR:Q9X868 (EMBL:AL049661) hypothetical 10.3 KD protein%2C SCE134.13 (102 aa)%2C fasta scores: opt: 543 z-score: 619.4 E(): 4.4e-27 80.0%25 identity in 100 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene6945 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6883 SCO6884 SCO6884 SC7F9.36c SC7F9.36c 7652497 7653630 - hypothetical protein SC7F9.36c%2C possible hypothetical protein%2C len: 377 aa. Highly similar to Streptomyces coelicolor TR:Q9X867(EMBL:AL049661) lipoprotein%2C SCE134.12 (381 aa)%2C fasta scores opt: 1374 z-score: 1462.4 E():0 56.0%25 identity in 384 aa overlap. Contains a Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family and a possible N-terminal signal sequence. gene gene6946 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6884 SCO6885 SCO6885 SC7F9.37 SC7F9.37 7654146 7654901 + DNA methylase SC7F9.37%2C possible DNA methylase%2C len: 251 aa. Similar to many methylases e.g. Moraxella bovis SW:MT1C_MORBO(EMBL:D13968) modification methylase MboI (EC 2.1.1.72) (273 aa)%2C fasta scores opt:208 z-score: 250.5 E(): 1.5e-06 24.5%25 identity in 253 aa overlap and Streptomyces coelicolor TR:Q9X866(EMBL:AL049661) DNA methylase%2C SCE134.11c (248 aa)%2C fasta scores opt: 976 z-score: 1145.8 E():0 57.6%25 identity in 250 aa overlap. Contains a Prosite hit to PS00092 N-6 Adenine-specific DNA methylases signature and a Pfam match to entry PF01555 N6_N4_Mtase%2C DNA methylase. gene gene6947 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6885 SCO6886 SCO6886 SC7F9.38 SC7F9.38 7655068 7655703 + hypothetical protein SC7F9.38%2C unknown%2C len: 211 aa. Highly similar to Streptomyces coelicolor TR:Q9X8A6 (EMBL:AL049645) hypothetical 21.3 KD protein%2C SCE2.11 (199 aa)%2C fasta scores opt: 562 z-score: 585.7 E(): 3.3e-25 44.4%25 identity in 189 aa overlap gene gene6948 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6886 SCO6887 SCO6887 SC7F9.39 SC7F9.39 7655700 7656185 + hypothetical protein SC7F9.39%2C hypothetical protein%2C len: 161 aa. Highly similar to Streptomyces coelicolor TR:Q9X8A8 (EMBL:AL049645) hypothetical 17.2 KD protein%2C SCE2.13 (158 aa)%2C fasta scores opt: 252 z-score: 254.1 E(): 9.7e-07 40.0%25 identity in 145 aa overlap. gene gene6949 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6887 SCO6888 SCO6888 SC7F9.40 SC7F9.40 7656204 7656902 + hypothetical protein SC7F9.40%2C unknown%2C len: 232 aa. gene gene6950 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6888 SCO6889 SCO6889 SC7F9.41 SC7F9.41 7656920 7657660 + hypothetical protein SC7F9.41%2C unknown%2C len: 246 aa. Similar to Streptomyces coelicolor TR:Q9X8A7 (EMBL:AL049645) hypothetical 28.5 KD protein%2C SCE2.12 (259 aa)%2C fasta scores opt: 405 z-score: 450.6 E(): 1.1e-17 35.6%25 identity in 233 aa overlap. gene gene6951 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6889 SCO6890 SCO6890 SC7F9.42 SC7F9.42 7657809 7658258 + hypothetical protein SC7F9.42%2C possible hypothetical protein%2C len: 149 aa. Contains a possible N-terminal signal sequence. gene gene6952 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6890 SCO6891 SCO6891 SC7F9.43 SC7F9.43 7658251 7658733 + hypothetical protein SC7F9.43%2C unknown%2C len: 160 aa gene gene6953 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6891 SCO6892 SCO6892 SC7F9.44 SC7F9.44 7658730 7659212 + hypothetical protein SC7F9.44%2C unknown%2C len: 160 aa. gene gene6954 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6892 SCO6893 SCO6893 SC7F9.45 SC7F9.45 7659287 7659598 + hypothetical protein SC7F9.45%2C unknown%2C len: 103 aa. gene gene6955 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6893 SCO6894 SCO6894 SC7F9.46 SC7F9.46 7659639 7660481 + hypothetical protein SC7F9.46%2C unknown%2C len: 280 aa. Contains a Pfam match to entry PF01638 DUF24%2C Protein of unknown function. gene gene6956 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6894 SCO6895 SCO6895 SC1B2.01 SC1B2.01 7660478 7660993 + regulator (fragment) SC1B2.01%2C possible regulator%2C partial CDS%2C len: > 51 aa. Overlaps and extends into CDS SC7F9.47 on the adjoining cosmid which is weakly similar to Streptomyces pilosus TR:Q54804(EMBL:Z50048) iron repressor%2C DesR.~SC7F9.47%2C possible regulator%2C partial CDS%2C len: >153 aa. Weakly similar to Streptomyces pilosus TR:Q54804(EMBL:Z50048) iron repressor%2C DesR (231 aa)%2C fasta scores opt: 113 z-score: 145.9 E(): 1 29.4%25 identity in 143 aa overlap. gene gene6957 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6895 SCO6896 SCO6896 SC1B2.02 SC1B2.02 7660990 7662225 + hypothetical protein SC1B2.02%2C possible integral membrane protein%2C len: 411 aa. Weakly similar to several e.g. Escherichia coli TR:Q47390(EMBL:D16251) erythromycin resistance determinant%2C MrX (388 aa)%2C fasta scores opt: 263 z-score: 283.2 E(): 2.6e-08 26.5%25 identity in 389 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene6958 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6896 SCO6897 SCO6897 SC1B2.03 SC1B2.03 7662258 7662569 + hypothetical protein SC1B2.03%2C unknown%2C len: 103 aa. gene gene6959 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6897 SCO6898 SCO6898 SC1B2.04 SC1B2.04 7662638 7663855 + carboxylase SC1B2.04%2C possible carboxylase%2C len: 405 aa. Weakly similar to several e.g. Anabaena sp. (strain PCC 7120) SW:ACCC_ANASP(EMBL:L14862) biotin carboxylase (EC 6.3.4.14) (447 aa)%2C fasta scores opt: 226 z-score: 262.2 E(): 3.8e-07 28.5%25 identity in 214 aa overlap. Contains a Pfam match to entry PF00289 CPSase_L_chain%2C Carbamoyl-phosphate synthase (CPSase) and a Prosite hit to PS00867 Carbamoyl-phosphate synthase subdomain signature 2. gene gene6960 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6898 SCO6899 SCO6899 SC1B2.05 SC1B2.05 7663852 7665003 + hypothetical protein SC1B2.05%2C possible membrane protein%2C len: 383 aa. Similar to several membrane transport proteins e.g. Rhizobium sp. (strain NGR234) SW:Y4WD_RHISN(EMBL:AE000103) hypothetical transport protein (377 aa)%2C fasta scores opt: 586 z-score: 584.6 E(): 4.2e-25 32.9%25 identity in 380 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene6961 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6899 SCO6900 SCO6900 SC1B2.06 SC1B2.06 7665000 7665629 + hypothetical protein SC1B2.06%2C unknown%2C len: 209 aa. Similar to Escherichia coli SW:YIHX_ECOLI (EMBL:L19201) hypothetical 22.7 kd protein (199 aa)%2C fasta scores opt: 181 z-score: 234.7 E(): 1.3e-05 28.0%25 identity in 189 aa overlap. gene gene6962 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6900 SCO6901 SCO6901 SC1B2.07 SC1B2.07 7665653 7666519 + hypothetical protein SC1B2.07%2C unknown%2C len: 288 aa. Similar to Streptomyces coelicolor TR:CAB72355(EMBL:AL138977) hypothetical 27.8 kd protein%2C SC7F9.02C (259 aa)%2C fasta scores opt: 229 z-score: 247.8 E(): 2.4e-06 31.4%25 identity in 283 aa overlap. gene gene6963 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6901 SCO6902 SCO6902 SC1B2.08 SC1B2.08 7666548 7667036 + hypothetical protein SC1B2.08%2C unknown%2C len: 162 aa. gene gene6964 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6902 SCO6903 SCO6903 SC1B2.09 SC1B2.09 7667084 7667884 + hypothetical protein SC1B2.09%2C unknown%2C len: 266 aa. Weakly similar to Streptomyces coelicolor TR:CAB72355(EMBL:AL138977) hypothetical 27.8 kd protein%2C SC7F9.02C (259 aa)%2C fasta scores opt: 149 z-score: 163.3 E(): 0.12 30.0%25 identity in 283 aa overlap. gene gene6965 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6903 SCO6904 SCO6904 SC1B2.10 SC1B2.10 7667918 7668928 + hypothetical protein SC1B2.10%2C possible membrane protein%2C len: 336 aa.Contains a possible membrane spanning hydrophobic domain. Rich in the amino acid Threonine gene gene6966 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6904 SCO6905 SCO6905 SC1B2.11 SC1B2.11 7669027 7669404 + hypothetical protein SC1B2.11%2C unknown%2C len: 125 aa. gene gene6967 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6905 SCO6906 SCO6906 SC1B2.12c SC1B2.12c 7669618 7671207 - hypothetical protein SC1B2.12c%2C unknown%2C len: 529 aa. Contains a 4xRPPHSPGPTPPRTKD repeat towards the C-terminal. Note low G+C content of this CDS (57.23 %25) gene gene6968 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6906 SCO6907 SCO6907 SC1B2.13 SC1B2.13 7671335 7672108 + DNA ligase SC1B2.13%2C possible DNA ligase%2C len: 257 aa. Similar in parts to Archaeoglobus fulgidus SW:DNLI_ARCFU(EMBL:AE001061) DNA ligase (EC 6.5.1.1) (556 aa)%2C fasta scores opt: 175 z-score: 199.4 E(): 0.0012 28.9%25 identity in 173 aa overlap and to Streptomyces coelicolor TR:Q9XAM3(EMBL:AL079355) DNA ligase%2C SC4C6.17C (355 aa)%2C fasta scores opt: 366 z-score: 413.9 E(): 1.4e-15 32.9%25 identity in 237 aa overlap. gene gene6969 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6907 SCO6908 SCO6908 SC1B2.14c SC1B2.14c 7672687 7673991 - hypothetical protein SC1B2.14c%2C unknown%2C len: 434 aa. gene gene6970 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6908 SCO6909 SCO6909 SC1B2.15 SC1B2.15 7674795 7675178 + hypothetical protein SC1B2.15%2C unknown%2C len: 127 aa. gene gene6971 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6909 SCO6910 SCO6910 SC1B2.16c SC1B2.16c 7675634 7676473 - insertion element transposase SC1B2.16c%2C insertion element IS468B transposase%2C len: 279 aa. Identical to several Streptomyces coelicolor transposases e.g. TR:Q9Z9H3(EMBL:AB024596) SCJ11.27C (279 aa)%2C fasta scores opt: 1839 z-score: 2192.4 E():0 99.6%25 identity in 279 aa overlap and TR:CAB38475(EMBL:AL035636) transposase SCH5.01 (fragment) (>229 aa)%2C fasta scores opt: 1502 z-score: 1793.3 E(): 0 100.0%25 identity in 229 aa overlap. Contains Pfam matches to entries PF01511 Transposase_6%2C Transposase and Pfam match to entry PF01675 Transposase_13%2C Transposase. gene gene6972 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6910 SCO6911 SCO6911 SC1B2.17 SC1B2.17 7676742 7677550 + gene gene6973 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6911 SCO6913 SCO6913 SC1B2.19 SC1B2.19 7677996 7678349 + hypothetical protein SC1B2.19%2C unknown%2C len: 117 aa. gene gene6974 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6913 SCO6914 SCO6914 SC1B2.20 SC1B2.20 7678455 7678745 + hypothetical protein SC1B2.20%2C unknown%2C len: 96 aa. gene gene6975 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6914 SCO6915 SCO6915 SC1B2.21 SC1B2.21 7678761 7679582 + hypothetical protein SC1B2.21%2C unknown%2C len: 273 aa. gene gene6976 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6915 SCO6916 SCO6916 SC1B2.22c SC1B2.22c 7679755 7680447 - hypothetical protein SC1B2.22c%2C hypothetical protein%2C len: 230 aa. Contains possible N-terminal region signal peptide sequence gene gene6977 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6916 SCO6917 SCO6917 SC1B2.23c SC1B2.23c 7680528 7681016 - hypothetical protein SC1B2.23c%2C unknown%2C len: 162 aa. gene gene6978 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6917 SCO6918 SCO6918 SC1B2.24c SC1B2.24c 7681180 7682922 - hypothetical protein SC1B2.24c%2C unknown%2C len: 580 aa. gene gene6979 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6918 SCO6919 SCO6919 SC1B2.25c SC1B2.25c 7682938 7683453 - hypothetical protein SC1B2.25c%2C unknown%2C len: 171 aa. The N-terminus of the predicted protein product of this CDS is hydrophilic. gene gene6980 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6919 SCO6920 SCO6920 SC1B2.26c SC1B2.26c 7683546 7683878 - hypothetical protein SC1B2.26c%2C doubtful CDS%2C len: 110 aa. gene gene6981 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6920 SCO6921 SCO6921 SC1B2.27c SC1B2.27c 7684057 7685787 - hypothetical protein SC1B2.27c%2C possible membrane protein%2C len: 576 aa. Contains a 4xPTTPQSGTDTTQDQG repeat sequence and multiple possible membrane spanning hydrophobic domains. gene gene6982 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6921 SCO6922 SCO6922 SC1B2.28c SC1B2.28c 7685784 7686425 - hypothetical protein SC1B2.28c%2C unknown%2C len: 213 aa. The N-terminus of this protein is highly similar to several proposed regulatory proteins e.g. Streptomyces coelicolor TR:Q9XAL5(EMBL:AL079355) transcriptional regulator%2C SC4C6.25 (81 aa)%2C fasta scores opt: 197 z-score: 226.2 E(): 3.9e-05 41.1%25 identity in 73 aa overlap. gene gene6983 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6922 SCO6923 SCO6923 SC1B2.29c SC1B2.29c 7686586 7687302 - hypothetical protein SC1B2.29c%2C unknown%2C len: 238 aa. gene gene6984 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6923 SCO6924 SCO6924 SC1B2.30c SC1B2.30c 7687305 7688201 - DNA-binding protein SC1B2.30c%2C possible DNA-binding protein%2C len: 298 aa. Contains a helix-turn-helix motif situated between residues 66..87 (+2.59 SD). gene gene6985 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6924 SCO6925 SCO6925 SC1B2.31c SC1B2.31c 7688836 7689048 - hypothetical protein SC1B2.31c%2C doubtful CDS (membrane protein)%2C len: 70 aa. Contains a TTA leucine codon%2C possible target for bldA regulation. Contains possible hydrophobic membrane spanning region gene gene6986 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6925 SCO6926 SCO6926 SC1B2.32 SC1B2.32 7689630 7690454 + hypothetical protein SC1B2.32%2C unknown%2C len: 274 aa. Weakly similar to several including: Streptomyces coelicolor TR:CAB53276 (EMBL:AL109972) DNA-binding protein%2C SCJ9A.15C (290 aa)%2C fasta scores opt: 225 z-score: 274.7 E(): 7.7e-08 29.0%25 identity in 238 aa overlap. gene gene6987 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6926 SCO6927 SCO6927 SC1B2.33c SC1B2.33c 7691781 7692905 - hypothetical protein SC1B2.33c%2C unknown%2C len: 374 aa. gene gene6988 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6927 SCO6928 SCO6928 SC1B2.34c SC1B2.34c 7692907 7694997 - O-methyltransferase SC1B2.34c%2C possible O-methyltransferase%2C len: 696 aa. Contains a central region which is similar to many protein-L-isoaspartate O-methyltransferases e.g. Escherichia coli SW:PIMT_ECOLI (EMBL:M63493) (207 aa)%2C fasta scores opt: 301 z-score: 340.3 E(): 1.7e-11 31.5%25 identity in 213 aa overlap and Streptomyces coelicolor TR:CAB71208 (EMBL:AL138538) SC6D10.13C (324 aa)%2C fasta scores opt: 442 z-score: 493.8 E(): 4.8e-20 36.9%25 identity in 306 aa overlap. Contains a Pfam match to entry PF01135 PCMT%2C Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT). gene gene6989 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6928 SCO6929 SCO6929 SC1B2.35c SC1B2.35c 7695016 7696275 - hypothetical protein SC1G8.01c%2C unknown%2C partial CDS%2Clen: >270 aa. Weakly similar to Bacillus subtilis SW:SPAC_BACSU (EMBL:M86869) subtilin biosynthetic protein%2C possibly involved in export%2C SpaC (441 aa)%2C fasta scores opt: 319 z-score: 378.0 E(): 1.4e-13 29.0%25 identity in 245 aa overlap.~SC1B2.35c%2C unknown%2C partial CDS%2C len: >181 aa. Similar to Streptomyces coelicolor TR:CAB55532 (EMBL:AL117322) hypothetical 49.0 kd protein%2C SCF1.12 (466 aa)%2C fasta scores opt: 238 z-score: 283.2 E(): 2.6e-08 31.1%25 identity in 180 aa overlap. gene gene6990 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6929 SCO6930 SCO6930 SC1G8.02c SC1G8.02c 7696262 7699360 - hypothetical protein SC1G8.02c%2C unknown%2C len: 1032 aa. Similar to a number of proteins involved in the posttranslational modification of the lantibiotics e.g. Bacillus subtilis SW:SPAB_BACSU (EMBL:L24075) subtilin biosynthesis protein%2C SpaB (1030 aa)%2C fasta scores opt: 516 z-score: 571.0 E(): 2.4e-24 22.1%25 identity in 988 aa overlap. Also similar to Streptomyces coelicolor TR:CAB55531 (EMBL:AL117322) hypothetical 114.5 kd protein%2C SCF1.11 (1053 aa)%2C fasta scores opt: 884 z-score: 982.0 E(): 0 30.6%25 identity in 1081 aa overlap. Contains a TTA leucine codon%2C possible target for bldA regulation gene gene6991 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6930 SCO6931 SCO6931 SC1G8.03c SC1G8.03c 7699447 7699626 - hypothetical protein SC1G8.03c%2C unknown%2C len: 59 aa. Highly similar to the upstream CDS SC1G8.04c (43 aa)%2C fasta scores opt: 261 z-score: 356.0 E(): 2.7e-14 97.5%25 identity in 40 aa overlap. gene gene6992 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6931 SCO6932 SCO6932 SC1G8.04c SC1G8.04c 7699664 7699795 - hypothetical protein SC1G8.04c%2C unknown%2C len: 43 aa. Highly similar to the downstream CDS SC1G8.03c (59 aa)%2C fasta scrores opt: 261 z-score: 356.0 E(): 2.7e-14 97.5%25 identity in 40 aa overlap. gene gene6993 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6932 SCO6933 SCO6933 SC1G8.05 SC1G8.05 7699873 7700322 + hypothetical protein SC1G8.05%2C unknown%2C len: 149 aa. gene gene6994 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6933 SCO6934 SCO6934 SC1G8.06c SC1G8.06c 7700261 7700728 - hypothetical protein SC1G8.06c%2C possible hypothetical protein%2C len: 155 aa. Contains a possible N-terminal signal sequence. gene gene6995 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6934 SCO6935 SCO6935 SC1G8.07c SC1G8.07c 7700803 7701378 - hypothetical protein SC1G8.07c%2C unknown%2C len: 191 aa. gene gene6996 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6935 SCO6936 SCO6936 SC1G8.08 SC1G8.08 7701375 7702028 - hypothetical protein SC1G8.08%2C unknown%2C len: 217 aa. Weakly similar to Streptomyces coelicolor TR:CAB56672 (EMBL:AL121596) hypothetical protein%2C SCF51A.20(252 aa)%2C fasta scores opt: 111 z-score: 140.7 E(): 2.2 27.9%25 identity in 190 aa overlap. gene gene6997 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6936 SCO6937 SCO6937 SC1G8.09c SC1G8.09c 7702025 7702585 - DNA-binding protein SC1G8.09c%2C possible DNA-binding protein%2C len: 186 aa. Contains a possible helix-turn-helix motif situated between residues 54..75 (+4.70 SD). gene gene6998 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6937 SCO6938 SCO6938 SC1G8.10c SC1G8.10c 7702634 7703887 - acyl-CoA dehydrogenase SC1G8.10c%2C probable acyl-CoA dehydrogenase%2C len: 417 aa. Similar to Bacillus subtilis TR:ACDB_BACSU (EMBL:U29084) acyl-CoA dehydrogenase (EC 1.3.99.-) MmgC (379 aa)%2C fasta scores opt: 651 z-score: 737.5 E(): 0 31.1%25 identity in 380 aa overlap and Streptomyces coelicolor TR:CAB87216 (EMBL:AL163641) acyl-CoA dehydrogenase%2C SCC105.10 (386 aa)%2C fasta scores opt: 575 z-score: 651.8 E(): 7.6e-29 31.7%25 identity in 382 aa overlap. Contains a Pfam match to entry PF00441 Acyl-CoA_dh%2C Acyl-CoA dehydrogenase and contains possible membrane spanning hydrophobic domains. gene gene6999 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6938 SCO6939 SCO6939 SC1G8.11c SC1G8.11c 7703970 7704611 - hypothetical protein SC1G8.11c%2C unknown%2C len: 213 aa. Similar to Streptomyces coelicolor TR:CAB71245(EMBL:AL138598) hypothetical 20.6 kd protein%2C SC1A2.07 (191 aa)%2C fasta scores opt: 376 z-score: 435.5 E(): 8.6e-17 43.9%25 identity in 164 aa overlap. gene gene7000 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6939 SCO6940 SCO6940 cvnD8 cvnD8 7704611 7705189 - ATP/GTP binding protein SC1G8.12c%2C cvnD8%2C possible ATP/GTP binding protein%2C len: 192 aa. Highly similar to many Streptomyces coelicolor ATP/GTP binding proteins including: TR:CAB71244(EMBL:AL138598) SC1A2.06 (184 aa)%2C fasta scores opt: 630 z-score: 788.4 E(): 0 56.6%25 identity in 182 aa overlap and TR:Q9X833(EMBL:AL049727) SC9B1.13C (181 aa)%2C fasta scores opt: 627 z-score: 784.8 E(): 0 58.0%25 identity in 176 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene7001 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6940 SCO6941 SCO6941 cvnC8 cvnC8 7705245 7705652 - hypothetical protein SC1G8.13c%2C cvnC8%2C unknown%2C len: 135 aa. Similar to many proteins of undefined function from Streptomyces coelicolor including: TR:O86520 (EMBL:AL031124) SC1C2.19C (132 aa)%2C fasta scores opt: 204 z-score: 259.5 E(): 5.4e-07 35.6%25 identity in 118 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa)%2C fasta scores opt: 137 z-score: 181.4 E(): 0.012 42.2%25 identity in 90 aa overlap. gene gene7002 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6941 SCO6942 SCO6942 cvnB8 cvnB8 7705649 7706164 - hypothetical protein SC1G8.14c%2C cvnB8%2C unknown%2C len: 171 aa. Similar to many proteins of undefined function from Streptomyces coelicolor including: TR:CAB61281(EMBL:AL132991) SCF55.11C (152 aa)%2C fasta scores opt: 158 z-score: 212.6 E(): 0.00022 33.1%25 identity in 160 aa overlap and TR:O86521(EMBL:AL031124) SC1C2.20C (140 aa)%2C fasta scores opt: 177 z-score: 237.3 E(): 9.4e-06 29.4%25 identity in 143 aa overlap. gene gene7003 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6942 SCO6943 SCO6943 cvnA8 cvnA8 7706226 7707743 - sensor histidine-kinase SC1G8.15c%2C cvnA8%2C possible sensor histidine-kinase%2C len: 505 aa. Highly similar to many proteins from Streptomyces coelicolor including: TR:CAB71241 (EMBL:AL138598) membrane protein%2C SC1A2.03 (650 aa)%2C fasta scores opt: 700 z-score: 669.8 E(): 7.6e-30 34.2%25 identity in 524 aa overlap and TR:CAB76341 (EMBL:AL158061) sensor histidine-kinase%2C SC6D11.18C (543 aa)%2C fasta scores opt: 433 z-score: 417.8 E(): 8.3e-16 28.6%25 identity in 482 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00512 signal%2C Histidine kinase. Also contains possible membrane spanning hydrophobic domains. gene gene7004 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6943 SCO6944 SCO6944 SC1G8.16c SC1G8.16c 7707771 7709672 - hypothetical protein SC1G8.16c%2C conserved hypothetical protein%2C len: 633 aa. Highly similar to several proteins of undefined function including: Streptomyces coelicolor TR:CAB52841 (EMBL:AL109848) SCI51.17 (612 aa)%2C fasta scores opt: 2658 z-score: 3108.3 E():0 64.4%25 identity in 590 aa overlap and Schizosaccharomyces pombe (Fission yeast) SW:YAY3_SCHPO (EMBL:Z69380) SPAC4H3.03C (649 aa)%2C fasta scores opt: 943 z-score: 1101.2 E():0 32.8%25 identity in 640 aa overlap. gene gene7005 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6944 SCO6945 SCO6945 SC1G8.17c SC1G8.17c 7709876 7710085 - hypothetical protein SC1G8.17c%2C possible membrane protein%2C len: 69 aa. Contains a possible membrane spanning hydrophobic domain. gene gene7006 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6945 SCO6946 SCO6946 SC1G8.18 SC1G8.18 7710167 7710406 + hypothetical protein SC1G8.18%2C unknown%2C len: 79 aa. gene gene7007 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6946 SCO6947 SCO6947 SC1G8.19 SC1G8.19 7710446 7711951 + hypothetical protein SC1G8.19%2C unknown%2C len: 501 aa. Similar to several including: Streptomyces griseus SW:SP15_STRGR (EMBL:M32687) sporulation protein (529 aa)%2C fasta scores opt: 530 z-score: 614.9 E(): 8.7e-27 28.5%25 identity in 534 aa overlap and Streptomyces coelicolor TR:O88053(EMBL:AL031541) transcriptional regulator%2C SCI35.15C (446 aa)%2C fasta scores opt: 537 z-score: 624.2 E(): 2.6e-27 31.4%25 identity in 440 aa overlap gene gene7008 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6947 SCO6948 SCO6948 SC1G8.20 SC1G8.20 7711970 7712521 + hypothetical protein SC6F7.01%2C unknown%2C partial CDS%2C len:> 157 aa. Weakly similar to several including: Aeropyrum pernix TR:Q9YFC8 (EMBL:AP000059) hypothetical protein (168 aa)%2C fasta scores opt: 231 z-score: 293.6 E(): 6.5e-09 35.8%25 identity in 137 aa overlap.~SC1G8.20%2C unknown%2C len: 183 aa. Weakly similar to several including: Aeropyrum pernix TR:Q9YFC8 (EMBL:AP000059) hypothetical protein (168 aa)%2C fasta scores opt: 231 z-score: 290.8 E(): 9.8e-09 35.8%25 identity in 137 aa overlap. Overlaps and extends into CDS SC6F7.01 on the adjoining cosmid. gene gene7009 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6948 SCO6949 SCO6949 SC6F7.02c SC6F7.02c 7712805 7713266 - hypothetical protein SC6F7.02c%2C unknown%2C len: 153 aa. Weakly similar to several including: Streptomyces albus TR:AAD46514 (EMBL:AF145724) regulatory protein%2C SitI (137 aa)%2C fasta scores opt:174 z-score: 238.9 E(): 7.2e-06 34.5%25 identity in 116 aa overlap. gene gene7010 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6949 SCO6950 SCO6950 SC6F7.03 SC6F7.03 7713425 7714828 + hypothetical protein SC6F7.03%2C unknown%2C len: 467 aa. Weakly similar to several including: Streptomyces coelicolor TR:Q9X7U7(EMBL:AL049863) regulatory protein%2C SC5H1.40C (502 aa)%2C fasta scores opt: 315 z-score: 356.4 E(): 2.1e-12 26.4%25 identity in 488 aa overlap. gene gene7011 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6950 SCO6951 SCO6951 SC6F7.04 SC6F7.04 7714825 7715706 + hypothetical protein SC6F7.04%2C unknown%2C len: 293 aa. Similar to Streptomyces coelicolor TR:Q9ZEP2(EMBL:AJ131213) hypothetical 30.7 kd protein%2C SCE94.11C (277 aa)%2C fasta scores: opt: 214 z-score: 251.4 E(): 1.5e-06 26.6%25 identity in 286 aa overlap gene gene7012 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6951 SCO6952 SCO6952 SC6F7.05c SC6F7.05c 7715801 7716844 - hypothetical protein SC6F7.05c%2C unknown%2C len: 347 aa. Weakly similar to several proteins of unknown function e.g. Mycobacterium tuberculosis SW:Y07U_MYCTU(EMBL:Z75555) (273 aa)%2C fasta scores opt: 173 z-score: 212.9 E(): 0.0002 26.8%25 identity in 276 aa overlap. gene gene7013 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6952 SCO6953 SCO6953 SC6F7.06c SC6F7.06c 7717864 7719441 - hypothetical protein SC6F7.06c%2C unknown%2C len: 525 aa%3B low similarity to Streptomyces coelicolor SCP1 plasmid borne TR:Q9ACU9 (EMBL:AL590464) Streptomyces coelicolor hypothetical protein SCP1.204c%2C 553 aa%3B fasta scores: opt: 617 Z-score: 687.1 E(): 1.2e-30%3B 29.916%25 identity in 478 aa overlap gene gene7014 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6953 SCO6954 SCO6954 SC6F7.07 SC6F7.07 7719817 7722720 + monovalent cation/H+ antiporter subunit A subunit A of antiporter complex involved in resistance to high concentrations of Na+%2C K+%2C Li+ and/or alkali gene gene7015 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6954 SCO6955 SCO6955 SC6F7.08 SC6F7.08 7722717 7723481 + monovalent cation/H+ antiporter subunit C subunit C of antiporter complex involved in resistance to high concentrations of Na+%2C K+%2C Li+ and/or alkali gene gene7016 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6955 SCO6956 SCO6956 SC6F7.09 SC6F7.09 7723478 7725217 + monovalent cation/H+ antiporter subunit D subunit D of antiporter complex involved in resistance to high concentrations of Na+%2C K+%2C Li+ and/or alkali%3B contains an oxidoreductase domain%3B catalyzes the transfer of electrons from NADH to ubiquinone gene gene7017 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6956 SCO6957 SCO6957 SC6F7.10 SC6F7.10 7725214 7725813 + monovalent cation/H+ antiporter subunit E subunit E of antiporter complex involved in resistance to high concentrations of Na+%2C K+%2C Li+ and/or alkali%3B in S. meliloti it is known to be involved specifically with K+ transport gene gene7018 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6957 SCO6958 SCO6958 SC6F7.11 SC6F7.11 7725810 7726127 + hypothetical protein SC6F7.11%2C possible membrane protein%2C len: 105 aa. Similar to two potassium-efflux system proteins from Rhizobium meliloti: TR:Q52983(EMBL:X93358) K-efflux system protein%2C PhaF (92 aa)%2C fasta scores opt: 160 z-score: 228.2 E(): 2.8e-05 34.9%25 identity in 86 aa overlap and SW:PHF2_RHIME(EMBL:L37353) PhaF2 (123 aa)%2C fasta scores opt: 166 z-score: 234.3 E(): 1.3e-05 37.5%25 identity in 96 aa overlap. Contains N-terminal membrane spanning hydrophobic domains. gene gene7019 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6958 SCO6959 SCO6959 SC6F7.12 SC6F7.12 7726124 7726489 + monovalent cation/H+ antiporter subunit G subunit G of antiporter complex involved in resistance to high concentrations of Na+%2C K+%2C Li+ and/or alkali%3B in S. meliloti it is known to be involved specifically with K+ transport gene gene7020 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6959 SCO6960 SCO6960 SC6F7.13c SC6F7.13c 7726503 7727039 - hypothetical protein SC6F7.13c%2C unknown%2C len: 178 aa. gene gene7021 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6960 SCO6961 SCO6961 SC6F7.14c SC6F7.14c 7727111 7728259 - hypothetical protein SC6F7.14c%2C unknown%2C len: 382 aa. Similar to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9XAC4 (EMBL:AL096839) SCC22.14C (368 aa)%2C fasta scores opt: 945 z-score: 1101.8 E():0 47.7%25 identity in 369 aa overlap. gene gene7022 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6961 SCO6962 SCO6962 SC6F7.15c SC6F7.15c 7728261 7729661 - glutamine synthetase SC6F7.15c%2C possible glutamine synthetase (EC 6.3.1.2)%2C len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa)%2C fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5%25 identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt%2C Glutamine synthetase gene gene7023 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6962 SCO6963 SCO6963 SC6F7.16c SC6F7.16c 7729774 7730619 - lipoprotein SC6F7.16c%2C possible lipoprotein%2C len: 281 aa. Weakly similar to Streptomyces coelicolor TR:Q54398 (EMBL:L42758) proteinase%2C SlpD or SCH5.02C (539 aa)%2C fasta scores opt: 137 z-score: 151.5 E(): 0.54 29.5%25 identity in 295 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7024 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6963 SCO6964 SCO6964 SC6F7.17c SC6F7.17c 7730937 7731587 - hypothetical protein SC6F7.17c%2C unknown%2C len: 216 aa. Similar to Mycobacterium tuberculosis TR:P95145(EMBL:Z83859) hypothetical 23.1 kd protein (211 aa)%2C fasta scores opt: 519 z-score: 613.8 E(): 9.4e-27 46.6%25 identity in 193 aa overlap gene gene7025 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6964 SCO6965 SCO6965 SC6F7.18c SC6F7.18c 7731590 7731922 - hypothetical protein SC6F7.18c%2C unknown%2C len: 110 aa. Similar to Streptomyces coelicolor TR:Q9XA81(EMBL:AL096837) possible DNA-binding protein%2C SCF43A.34C (113 aa)%2C fasta scores opt: 235 z-score: 310.8 E(): 7.5e-10 40.4%25 identity in 109 aa overlap. gene gene7026 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6965 SCO6966 SCO6966 SC6F7.19c SC6F7.19c 7732266 7733075 - lipase SC6F7.19c%2C possible lipase%2C len: 269 aa. Similar to many other lipases e.g. Thermotoga maritima TR:Q9X171(EMBL:AE001789) lipase%2C (259 aa)%2C fasta scores opt: 345 z-score: 396.1 E(): 1.3e-14 33.1%25 identity in 239 aa overlap. contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene7027 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6966 SCO6967 SCO6967 pcaF pcaF 7733254 7734441 + beta-ketoadipyl-CoA thiolase SC6F7.20%2C pcaF%2C beta-ketoadipyl-CoA thiolase%2C len: 395 aa. Highly similar to many including: Pseudomonas putida SW:PCAF_PSEPU(EMBL:U10895) beta-ketoadipyl CoA thiolase (EC 2.3.1.-) (400 aa)%2C fasta scores opt: 1352 z-score: 1491.2 E(): 0 53.9%25 identity in 399 aa overlap and Streptomyces coelicolor TR:Q9XAM9(EMBL:AL079355) beta-ketoadipyl-CoA thiolase%2C SC4C6.11C (400 aa)%2C fasta scores opt: 1450 z-score: 1598.9 E(): 0 56.9%25 identity in 401 aa overlap. Contains a Pfam match to entry PF00108 thiolase%2C Thiolase and Prosite hits to PS00098 Thiolases acyl-enzyme intermediate signature%2C PS00737 Thiolases signature 2 and PS00099 Thiolases active site. gene gene7028 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6967 SCO6968 SCO6968 SC6F7.21 SC6F7.21 7734509 7736044 + long-chain-fatty-acid-CoA ligase SC6F7.21%2C probable long-chain-fatty-acid-CoA ligase%2C len: 511 aa. Similar to several including: Bacillus subtilis SW:LCFA_BACSU (EMBL:Z75208) long-chain-fatty-acid-CoA ligase (EC 6.2.1.3) (560 aa)%2C fasta scores opt: 877 z-score: 981.0 E():0 35.4%25 identity in 534 aa overlap and Archaeoglobus fulgidus TR:O28502 (EMBL:AE000980) long-chain-fatty-acid-CoA ligase (569 aa)%2C fasta scores opt: 971 z-score: 1085.9 E():0 38.1%25 identity in 525 aa overlap. Contains a Prosite hit to PS00455 AMP-binding domain signature and a Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme. gene gene7029 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6968 SCO6969 SCO6969 SC6F7.22 SC6F7.22 7736107 7736880 + hypothetical protein SC6F7.22%2C possible integral membrane protein%2C len: 257 aa. Similar to several proteins of undefined function e.g. Campylobacter jejuni TR:CAB73891(EMBL:AL139078) integral membrane protein (254 aa)%2C fasta scores opt: 176 z-score: 216.1 E(): 0.00013 24.4%25 identity in 254 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7030 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6969 SCO6970 SCO6970 SC6F7.23c SC6F7.23c 7736807 7738951 - membrane transport protein SC6F7.23c. possible membrane transport protein%2C len: 714 aa. Similar to many including: Bacillus subtilis TR:P96712(EMBL:D50098) multi drug transporter Bmr3 (512 aa)%2C fasta scores opt: 1027 z-score: 1100.4 E():0 34.5%25 identity in 498 aa overlap. Also similar to several from Streptomyces coelicolor e.g. TR:Q9ZBJ1(EMBL:AL035161) efflux protein%2C SC9C7.19 (815 aa)%2C fasta scores opt: 1639 z-score: 1751.6 E():0 49.4%25 identity in 530 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and multiple possible membrane spanning hydrophobic domains. gene gene7031 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6970 SCO6971 SCO6971 SC6F7.24c SC6F7.24c 7739022 7739795 - precorrin 6A synthase catalyzes the formation of precorrin 6x from precorrin 5 gene gene7032 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6971 SCO6972 SCO6972 SC6F7.25c. SC6F7.25c. 7739853 7740392 - hypothetical protein SC6F7.25c%2C unknown%2C len: 179 aa. gene gene7033 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6972 SCO6973 SCO6973 SC6F7.26c SC6F7.26c 7740635 7741057 - hypothetical protein SC6F7.26c%2C unknown%2C len: 140 aa. Similar%2C in parts%2C to proteins containing the principally Eukaryotic ankyrin repeat motifs e.g. Chromatium vinosum SW:ANKH_CHRVI(EMBL:L13419) ankyrin homolog precursor (323 aa)%2C fasta scores opt: 200 z-score: 247.0 E(): 2.5e-06 38.4%25 identity in 125 aa overlap. Contains 2xPfam matches to entry PF00023 ank%2C Ank repeat. gene gene7035 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6973 SCO6974 SCO6974 SC6F7.27c SC6F7.27c 7741171 7741956 - GntR family transcriptional regulator SC6F7.27c%2C possible GntR-family regulatory protein%2C len: 261 aa. Similar to many regulators e.g. Escherichia coli SW:FARR_ECOLI (EMBL:X15790) fatty acyl responsive regulator (P30 protein) FarR (240 aa)%2C fasta scores opt: 260 z-score: 313.4 E(): 5.1e-10 26.1%25 identity in 226 aa overlap and Streptomyces coelicolor TR:CAB60175 (EMBL:AL132824) transcriptional regulator%2C SCAH10.21 (245 aa)%2C fasta scores opt: 1194 z-score: 1406.5 E():0 74.5%25 identity in 243 aa overlap. Contains a Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family with the helix-turn-helix motif situated between residues 55..76 (+4.16 SD). gene gene7036 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6974 SCO6975 SCO6975 SC6F7.28c SC6F7.28c 7742010 7743884 - 3D-(3%2C5/4)-trihydroxycyclohexane-1%2C2-dione acylhydrolase (decyclizing) SC8F11.01c%2C possible amino acid synthase%2C partial CDS%2C len: > 237 aa. Similar to several enzymes requiring TPP as a cofactor including: Spirulina platensis SW:ILVB_SPIPL(EMBL:M75907) acetolactate synthase (EC 4.1.3.18) IlvY (579 aa)%2C fasta scores opt: 166 z-score: 195.5 E(): 0.0019 27.7%25 identity in 238 aa overlap. Also highly similar%2C in parts%2C to the Bacillus subtilis SW:IOLD_BACSU(EMBL:D14399) hypothetical protein%2C IolD found within the inositol utilisation operon (580 aa)%2C fasta scores opt: 577 z-score: 669.1 E(): 7.7e-30 47.2%25 identity in 178 aa overlap. Contains a Pfam match to entry PF00205 TPP_enzymes%2C Thiamine pyrophosphate enzymes.~SC6F7.28c%2C probable acetolactate synthase%2C partial CDS%2C len: > 420 aa. Similar to many acetolactate synthases including: Mycobacterium tuberculosis SW:ILVB_MYCTU(EMBL:Z78020) probable acetolactate synthase (EC 4.1.3.18) (547 aa)%2C fasta scores opt: 492 z-score: 552.0 E(): 2.6e-23 29.1%25 identity in 388 aa overlap. Also similar to Bacillus subtilis SW:IOLD_BACSU(EMBL:D14399) myo-inositol catabolic protein IolD (580 aa)%2C fasta scores opt: 408 z-score: 458.5 E(): 4.3e-18 34.8%25 identity in 443 aa overlap. Contains a Pfam match to entry PF00205 TPP_enzymes%2C Thiamine pyrophosphate enzymes. gene gene7037 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6975 SCO6976 SCO6976 SC8F11.02c SC8F11.02c 7743881 7744777 - 5-deoxy-glucuronate isomerase SC8F11.02c%2C unknown%2C len: 298 aa. Similar to the Bacillus subtilis SW:IOLB_BACSU(EMBL:D14399) hypothetical protein%2C IolB%2C found within the inositol utilisation operon (271 aa)%2C fasta scores opt: 443 z-score: 516.6 E(): 2.4e-21 34.9%25 identity in 281 aa overlap gene gene7038 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6976 SCO6977 SCO6977 SC8F11.03c SC8F11.03c 7744831 7745727 - hypothetical protein SC8F11.03c%2C unknown%2C len: 298 aa. weakly similar to Streptomyces coelicolor TR:CAB59608 (EMBL:AL132662) histidine kinase%2C SCF11.31C (442 aa)%2C fasta scores opt: 131 z-score: 160.7 E(): 0.16 30.2%25 identity in 265 aa overlap. gene gene7039 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6977 SCO6978 SCO6978 SC8F11.04c SC8F11.04c 7745741 7746703 - 5-dehydro-2-deoxygluconokinase SC8F11.04c%2C possible carbohydrate kinase%2C len: 320 aa. Similar to many fructokinases (EC 2.7.1.4) including: Klebsiella pneumoniae SW:SCRK_KLEPN (EMBL:X61004) ScrK (307 aa)%2C fasta scores opt: 378 z-score: 438.7 E(): 5.3e-17 32.8%25 identity in 311 aa overlap. Also similar to Bacillus subtilis SW:IOLC_BACSU(EMBL:D14399) hypothetical protein%2C IolC%2C found within the inositol utilisation operon (325 aa)%2C fasta scores opt: 583 z-score: 672.7 E(): 4.9e-30 30.0%25 identity in 313 aa overlap. Contains a Prosite hit to PS00583 pfkB family of carbohydrate kinases signature 1 and a Pfam match to entry PF00294 pfkB%2C pfkB family carbohydrate kinase. gene gene7040 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6978 SCO6979 SCO6979 SC8F11.05 SC8F11.05 7746957 7747979 + solute-binding lipoprotein SC8F11.05%2C probable solute-binding lipoprotein%2C len: 340 aa. Highly similar to many sugar transport proteins including Bacillus subtilis SW:RBSB_BACSU(EMBL:Z92953) D-ribose-binding protein precursor%2C RbsB (305 aa)%2C fasta scores opt: 222 z-score: 243.9 E(): 3.7e-06 23.0%25 identity in 256 aa overlap and several examples from Streptomyces coelicolor e.g. TR:Q9X837(EMBL:AL049727) solute binding protein%2C SC9B1.17C (337 aa)%2C fasta scores opt: 1281 z-score: 1360.6 E():0 59.1%25 identity in 328 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7041 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6979 SCO6980 SCO6980 SC8F11.06 SC8F11.06 7747976 7749055 + ABC transporter membrane protein SC8F11.06%2C probable ABC transporter%2C membrane component%2C len: 359 aa. Similar to several including: Escherichia coli SW:MGLC_ECOLI(EMBL:M59444) galactoside transport system permease%2C MglC (336 aa)%2C fasta scores opt: 455 z-score: 517.3 E(): 2.2e-21 29.2%25 identity in 329 aa overlap and several examples from Streptomyces coelicolor e.g. TR:CAB60177(EMBL:AL132824) ABC transport system sugar permease%2C SCAH10.23 (346 aa)%2C fasta scores opt: 1426 z-score: 1605.5 E():0 62.2%25 identity in 336 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7042 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6980 SCO6981 SCO6981 SC8F11.07 SC8F11.07 7749062 7750054 + ABC transporter ATP-binding protein gene gene7043 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6981 SCO6982 SCO6982 SC8F11.08 SC8F11.08 7750057 7750959 + hypothetical protein SC8F11.08%2C unknown%2C len:300 aa. Similar to a protein of undefined function involved in rhizopine catabolism in Rhizobium meliloti SW:MOCC_RHIME(EMBL:X78503) MocC (325 aa)%2C fasta scores opt: 390 z-score: 432.2 E(): 1.2e-16 29.8%25 identity in 289 aa overlap. Also similar to Bacillus subtilis SW:IOLE_BACSU(EMBL:D14399) IolE%2C found within the inositol utilisation operon (297 aa)%2C fasta scores opt: 313 z-score: 348.9 E(): 5.3e-12 26.3%25 identity in 293 aa overlap. gene gene7044 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6982 SCO6983 SCO6983 SC8F11.09 SC8F11.09 7751075 7751488 + hypothetical protein SC8F11.09%2C unknown%2C len: 137 aa. Weakly similar to a protein of undefined function from Mycobacterium tuberculosis SW:Y887_MYCTU(EMBL:Z73101) (152 aa)%2C fasta scores opt: 193 z-score: 239.5 E(): 6.6e-06 31.7%25 identity in 139 aa overlap. gene gene7045 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6983 SCO6984 SCO6984 SC8F11.10c SC8F11.10c 7751527 7752603 - oxidoreductase SC8F11.10c%2C possible oxidoreductase%2C len: 358 aa. Similar to many including: Sinorhizobium meliloti TR:O68965(EMBL:) myo-inositol dehydrogenase (EC 1.1.1.18) IdhA (330 aa)%2C fasta scores opt: 715 z-score: 789.8 E(): 0 39.6%25 identity in 338 aa overlap and Streptomyces coelicolor TR:CAB60174(EMBL:AL132824) dehydrogenase%2C SCAH10.20C (337 aa)%2C fasta scores opt: 1068 z-score: 1176.0 E(): 0 50.8%25 identity in 333 aa overlap. Note codon 25 offers an alternative translational start site. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene7046 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6984 SCO6985 SCO6985 SC8F11.11c SC8F11.11c 7752600 7753763 - hypothetical protein SC8F11.11c%2C unknown%2C len: 387 aa. gene gene7047 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6985 SCO6986 SCO6986 SC8F11.12 SC8F11.12 7753893 7754939 + DNA-binding protein SC8F11.12%2C possible DNA-binding protein%2C len: 348 aa. Weakly similar to a hypothetical protein located on the Agrobacterium tumefaciens Ti-plasmid TR:BAA87720 (EMBL:AB016260) TiORF95 (336 aa)%2C fasta scores opt: 464 z-score: 513.2 E(): 3.7e-21 29.8%25 identity in 329 aa overlap and to TR:CAC46423 (EMBL:AL591788) Rhizobium meliloti hypothetical transcription regulator protein SMC00163%2C 340 aa%3B fasta scores: opt: 1133 Z-score: 1207.2 E(): 1.3e-59%3B 52.959%25 identity in 338 aa overlap. Contains a helix-turn-helix motif situated between residues 5..26 (+5.89 SD) gene gene7048 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6986 SCO6987 SCO6987 SC8F11.13 SC8F11.13 7755003 7755470 + hypothetical protein SC8F11.13%2C membrane protein%2C len: 85 aa. Contains possible hydrophobic membrane spanning regions gene gene7049 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6987 SCO6988 SCO6988 SC8F11.14c SC8F11.14c 7755621 7756784 - oxidoreductase SC8F11.14c%2C possible oxidoreductase%2C len: 387 aa. Similar to several including: Sinorhizobium meliloti TR:O68965(EMBL:) myo-inositol dehydrogenase (EC 1.1.1.18) IdhA (330 aa)%2C fasta scores opt: 287 z-score: 332.8 E(): 4.2e-11 30.1%25 identity in 356 aa overlap and Streptomyces coelicolor TR:O69945(EMBL:AL023862) oxidoreductase%2C SC3F9.05 (430 aa)%2C fasta scores opt: 721 z-score: 825.3 E():0 34.6%25 identity in 390 aa overlap. Contains a Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene7050 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6988 SCO6989 SCO6989 SC8F11.15c SC8F11.15c 7756901 7757431 - hypothetical protein SC8F11.15c%2C unknown%2C len: 176 aa. gene gene7051 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6989 SCO6990 SCO6990 SC8F11.16c SC8F11.16c 7757496 7758473 - membrane transport protein SC8F11.16c%2C possible membrane transport protein%2C len: 325 aa. Similar to several Eukaryotic and Prokaryotic membrane transporters including: Homo sapiens SW:NTCI_HUMAN(EMBL:U10417) ileal sodium/bile acid co-transporter (348 aa)%2C fasta scores opt: 413 z-score: 449.9 E(): 1.3e-17 33.7%25 identity in 249 aa overlap and Aquifex aeolicus TR:O67889(EMBL:AE000774) Na(+) dependent transporter (297 aa)%2C fasta scores opt: 763 z-score: 824.8 E():0 42.9%25 identity in 289 aa overlap. Contains a Pfam match to entry PF01758 SBF%2C Sodium Bile acid symporter family. Contains multiple possible membrane spanning hydrophobic domains. gene gene7052 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6990 SCO6991 SCO6991 SC8F11.17 SC8F11.17 7758904 7759110 + hypothetical protein SC8F11.17%2C unknown%2C len: 68 aa. gene gene7053 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6991 SCO6992 SCO6992 absR1 absR1 7759825 7760904 - regulatory protein SC8F11.18c%2C absR1%2C regulatory protein%2C len: 359 aa. Identical to that previously sequenced: Streptomyces coelicolor TR:AAF19103(EMBL:AF136167) activator of secondary metabolism%2C AbsR1. gene gene7055 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6992 SCO6993 SCO6993 absR2 absR2 7760983 7762803 + regulatory protein SC8F11.19%2C absR2%2C regulatory protein%2C len: 606 aa. Shares 98.8 %25 sequence identity with that previously sequenced: Streptomyces coelicolor TR:AAF19103 (EMBL:AF136167) repressor of secondary metabolism%2C AbsR2. Contains a PS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family%2C with a helix-turn-helix motif situated between residues 559..580 (+4.00 SD) gene gene7056 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6993 SCO6994 SCO6994 SC8F11.20c SC8F11.20c 7762852 7766112 - hypothetical protein SC8F11.20c%2C unknown%2C len: 1068 aa. gene gene7057 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6994 SCO6995 SCO6995 SC8F11.21 SC8F11.21 7766257 7767690 + protease SC8F11.21%2C possible protease%2C len: 477 aa. Weakly similar in parts to a number or serine proteases e.g. Thermoactinomyces sp. TR:Q56365(EMBL:U31759) thermostable alkaline protease (384 aa)%2C fast scores opt: 220 z-score: 245.7 E(): 3e-06 26.2%25 identity in 263 aa overlap. Contains Prosite hits to PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site%2CPS00137 Serine proteases%2C subtilase family%2C histidine active site and PS00138 Serine proteases%2C subtilase family%2C serine active site. gene gene7058 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6995 SCO6996 SCO6996 SC8F11.22 SC8F11.22 7767762 7768337 + RNA polymerase sigma factor SC8F11.22%2C possible RNA polymerase sigma factor%2C len: 191 aa. Weakly similar to Streptomyces coelicolor sigma factor TR:CAB76082 (EMBL:AL157953) RNA polymerase sigma factor%2C SCL11.20C (166 aa)%2C fasta scores opt: 206 z-score: 259.9 E(): 4.8e-07 30.4%25 identity in 161 aa overlap. gene gene7059 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6996 SCO6997 SCO6997 SC8F11.23 SC8F11.23 7768334 7768825 + hypothetical protein SC8F11.23%2C unknown%2C len: 163 aa. The very N-terminus is Asp rich. gene gene7060 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6997 SCO6998 SCO6998 SC8F11.24c SC8F11.24c 7768860 7770083 - cytochrome P450 SC8F11.24c%2C possible cytochrome P450%2C len: 407 aa. Similar to many possible cytochrome P450s including: Streptomyces griseolus SW:CPXF_STRGO (EMBL:M32239) cytochrome P450-SU2 (402 aa)%2C fasta scores opt: 735 z-score: 827.8 E(): 0 34.3%25 identity in 408 aa overlap. Contains 2xPfam matches to entries PF00067 p450%2C Cytochrome P450. gene gene7061 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6998 SCO6999 SCO6999 SC8F11.25c. SC8F11.25c. 7770163 7770960 - hypothetical protein SC8F11.25c%2C unknown%2C len: 265 aa. gene gene7062 http://www.ncbi.nlm.nih.gov/gene/?term=SCO6999 SCO7000 SCO7000 idh idh 7771060 7773279 - isocitrate dehydrogenase SC8F11.26c%2C idh%2C isocitrate dehydrogenase%2C len: 739 aa. Shares 97.8%25 sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh%2C 741 aa TR:Q9X5M9(EMBL:AF127018) gene gene7063 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7000 SCO7001 SCO7001 SC8F11.27c SC8F11.27c 7773382 7774443 - hypothetical protein SC8F11.27c%2C possible integral membrane protein%2C len: 353 aa. Similar to many proteins of undefined function including: Methanococcus jannaschii SW:Y170_METJA(EMBL:U67474) (350 aa)%2C fasta scores opt: 410 z-score: 451.3 E(): 1e-17 26.3%25 identity in 335 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Also contains a Pfam match to entry PF00924 UPF0003%2C Uncharacterized protein family UPF0003 gene gene7064 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7001 SCO7002 SCO7002 SC8F11.28c SC8F11.28c 7774616 7776130 - amino acid/metabolite permease SC8F11.28c%2C probable amino acid/metabolite permease%2C len: 504 aa. Highly similar to many Eukaryotic and Prokaryotic permeases including: Saccharomyces cerevisiae SW:UGA4_YEAST(EMBL:X66472) GABA-specific permease (571 aa)%2C fasta scores opt: 583 z-score: 659.1 E(): 2.8e-29 30.8%25 identity in 510 aa overlap and Streptomyces coelicolor TR:CAB56378(EMBL:AL118515) possible amino acid/metabolite permease (fragment)%2C SCD17.01 (389 aa)%2C fasta scores opt: 1521 z-score: 1718.0 E():0 62.7%25 identity in 359 aa overlap. Contains a Prosite hit to PS00218 Amino acid permeases signature and a Pfam match to entry PF00324 aa_permeases%2C Amino acid permease. Also contains multiple possible membrane spanning hydrophobic domains. gene gene7065 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7002 SCO7003 SCO7003 SC8F11.29c SC8F11.29c 7776162 7777172 - hypothetical protein SC8F11.29c%2C unknown%2C len: 336 aa. Similar in parts to a protein of undefined function from Streptomyces coelicolor: TR:CAB46782(EMBL:AL096811) SCI30A.05C (338 aa)%2C fasta scores opt: 249 z-score: 278.0 E(): 4.7e-08 34.8%25 identity in 319 aa overlap. gene gene7066 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7003 SCO7004 SCO7004 SC8F11.30 SC8F11.30 7777445 7778884 + carbohydrate kinase SC8F11.30%2C probable carbohydrate kinase%2Clen: 479 aa. Highly similar to many e.g. Bacillus subtilis SW:GLPK_BACSU(EMBL:M34393) glycerol kinase (EC 2.7.1.30)%2C GlpK (496 aa)%2C fasta scores opt: 688 z-score: 766.4 E():0 35.1%25 identity in 496 aa overlap. Contains a Pfam match to entry PF00370 FGGY%2C FGGY family of carbohydrate kinases. gene gene7067 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7004 SCO7005 SCO7005 SC8F11.31 SC8F11.31 7778881 7780284 + oxidoreductase SC8F11.31%2C possible oxidoreductase%2C len: 467 aa. Similar to several including: Homo sapiens TR:AAF21941(EMBL:AF111858) dimethylglycine dehydrogenase precursor (EC 1.5.99.2) (866 aa)%2C fasta scores opt: 217 z-score: 242.0 E(): 4.7e-06 24.7%25 identity in 372 aa overlap and Pyrococcus abyssi TR:CAB49193(EMBL:AJ248283) glycerol-3-phosphate dehydrogenase%2C GlpA (497 aa)%2C fasta scores opt: 787 z-score: 883.5 E(): 0 36.1%25 identity in 454 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh%2C FAD-dependent glycerol-3-phosphate dehydrogenase. Also contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7068 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7005 SCO7006 SCO7006 SC8F11.32 SC8F11.32 7780281 7781531 + oxidoreductase SC8F11.32%2C possible oxidoreductase%2C len: 416 aa. Similar to several e.g. Mycobacterium smegmatis SW:TRXB_MYCSM(EMBL:AF023161) thioredoxin reductase (EC 1.6.4.5) (311 aa)%2C fasta scores opt: 323 z-score: 335.5 E(): 2.9e-11 30.6%25 identity in 314 aa overlap. gene gene7069 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7006 SCO7007 SCO7007 SC8F11.33 SC8F11.33 7781548 7782447 - hypothetical protein SC8F11.33%2C possible integral membrane protein%2C len: 299 aa. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene7070 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7007 SCO7008 SCO7008 SC8F11.34 SC8F11.34 7782661 7784535 + ABC transporter ATP-binding protein gene gene7071 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7008 SCO7009 SCO7009 SC8F11.35c SC8F11.35c 7784586 7786367 - hypothetical protein SC8F11.35c%2C unknown%2C len: 593 aa. Identical%2C apart from the very C-terminus%2C to Streptomyces lividans TR:O86875(EMBL:U22894) hypothetical 57.9 kd protein%2C AglX (547 aa)%2C fasta scores opt: 3357 z-score: 3741.0 E(): 0 98.8%25 identity in 519 aa overlap. Also highly similar to several Streptomyces coelicolor hypothetical proteins e.g. TR:CAB61537(EMBL:AL133171) SCF81.26 (835 aa)%2C fasta scores opt: 1133 z-score: 1260.6 E(): 0 43.0%25 identity in 575 aa overlap. gene gene7072 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7009 SCO7010 SCO7010 aglA aglA 7786480 7788084 - alpha glucosidase SC8F11.36c%2C aglA%2C alpha glucosidase%2C len: 534 aa. Identical to Streptomyces lividans TR:O86874(EMBL:U22894) alpha glucosidase%2C AglA (534 aa)%2C fasta scores opt: 3764 z-score: 4189.4 E(): 0 99.6%25 identity in 534 aa overlap. Also highly similar to many other glycosyl hydrolases e.g. Escherichia coli SW:TREC_ECOLI(EMBL:U06195) trehalose-6-phosphate hydrolase (EC 3.2.1.93) (551 aa)%2C fasta scores opt: 882 z-score: 982.3 E():0 36.1%25 identity in 523 aa overlap and Streptomyces coelicolor SC10B7.07 (577 aa)%2C fasta scores opt: 1026 z-score: 1004.4 E():0 55.0%25 identity in 565 aa overlap. Contains a Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase. gene gene7073 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7010 SCO7011 SCO7011 SC8F11.37c SC8F11.37c 7788229 7789104 - membrane transport protein SC8F11.37c%2C possible membrane transport protein%2C len: 291 aa. Identical to Streptomyces lividans TR:O86873(EMBL:U22894) integral membrane protein%2C AglG (291 aa)%2C fasta scores opt: 1890 z-score: 2239.5 E():0 100.0%25 identity in 291 aa overlap. Also similar to many sugar transport proteins e.g. Clostridium perfringens TR:Q06111(EMBL:X66092) transport system permease (275 aa)%2C fasta scores opt: 515 z-score: 616.2 E(): 6.9e-27 32.4%25 identity in 259 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and multiple possible membrane spanning hydrophobic domains. gene gene7074 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7011 SCO7012 SCO7012 SC1H10.01c SC1H10.01c 7789123 7790082 - binding protein dependent transport protein SC1H10.01c%2C possible binding protein dependent transport protein%2C partial CDS%2C len: > 288 aa. Almost identical to Streptomyces lividans TR:O86872(EMBL:U22894) integral membrane protein%2C AglF (231 aa)%2C fasta scores opt: 1469 z-score: 1755.6 E(): 0 96.9%25 identity in 224 aa overlap. Also similar to Streptomyces coelicolor TR:CAB59596(EMBL:AL132662) probable sugar transporter inner membrane protein%2C SCF11.19 (316 aa)%2C fasta scores opt: 575 z-score: 690.1 E(): 5.1e-31 38.1%25 identity in 273 aa overlap. Contains a Prosite hit to PS00402 Binding-protein-dependent transport systems inner membrane comp sign and a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains multiple possible membrane spanning hydrophobic domains.~SC8F11.38c%2C possible membrane transport protein%2C partial CDS%2C len:> 71 aa. Similar to several e.g. Streptococcus mutans SW:MSMF_STRMU(EMBL:M77351) multiple sugar-binding transport system permease%2C MsmF (290 aa)%2C fasta scores opt: 167 z-score: 244.0 E(): 3.8e-06 43.1%25 identity in 65 aa overlap. Contains possible membrane spanning hydrophobic domains. Overlaps and extends into CDS SC1H10.01c on the adjoining cosmid. gene gene7075 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7012 SCO7013 SCO7013 SC1H10.02c SC1H10.02c 7790150 7791565 - sugar-binding lipoprotein SC1H10.02C%2C possible sugar-binding lipoprotein%2C len: 471 aa. Identical to Streptomyces lividans TR:Q54334(EMBL:U22894) sugar binding lipoprotein precursor%2C AlgE (471 aa)%2C fasta scores opt: 3154 z-score: 3469.8 E():0 100.0%25 identity in 471 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7076 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7013 SCO7014 SCO7014 SC1H10.03c SC1H10.03c 7791717 7792730 - LacI family transcriptional regulator SC1H10.03c%2C probable LacI-family transcriptional regulatory protein%2C len: 337 aa. Identical to Streptomyces lividans protein encoded on the 1 kb TR:Q57276 (EMBL:X65466) right direct repeat sequence contained within the amplifiable AUD1 element (337 aa)%2C fasta scores opt: 2188 z-score: 2534.7 E():0 99.7%25 identity in 337 aa overlap. Also highly similar to Streptomyces coelicolor SW:MALR_STRCO (EMBL:Y07706) maltose operon transcriptional repressor%2C MalR or SC10B7.03c (344 aa)%2C fasta scores opt: 1114 z-score: 1293.5 E():0 53.3%25 identity in 336 aa overlap. This gene is duplicated on this cosmid and shares 94%25 identity in a 337 bp overlap with CDS SC1H10.05c. Contains Pfam hits to Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family with the helix-turn-helix motif situated between residues 3..24 (+7.33 SD). gene gene7077 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7014 SCO7015 SCO7015 SC1H10.04c SC1H10.04c 7792823 7797124 - glycosyl hydrolase SC1H10.04c%2C possible glycosyl hydrolase%2C len: 1433 aa. Identical to Streptomyces lividans TR:P75020(EMBL:U22894) chitinase homolog found within the 4.7 kb amplifiable unit of the AUD1 element (1433 aa)%2C fasta scores opt: 9322 z-score: 9526.2 E():0 99.5%25 identity in 1433 aa overlap. C-terminal similar to TR:BAB62749 (EMBL:AB055506) mycodextranase from Streptomyces sp. J-13-3 fasta scores%3B opt: 865%2C Z-score: 887.6%2C 32.953%25 identity (36.861%25 ungapped) in 613 aa overlap. Also weakly similar%2C in parts%2C to Bacillus circulans SW:CHI1_BACCI(EMBL:M57601) chitinase A1 precursor (EC 3.2.1.14) (699 aa)%2C fasta scores opt: 497 z-score: 507.9 E(): 7.2e-21 47.3%25 identity in 182 aa overlap. Contains a possible N-terminal signal sequence and 2x Pfam matches to entries PF00041 fn3%2C Fibronectin type III domain. gene gene7078 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7015 SCO7016 SCO7016 SC1H10.05c SC1H10.05c 7797371 7798381 - LacI family transcriptional regulator SC1H10.05c%2C possible LacI-family transcriptional regulatory protein%2C len: 336 aa. Identical to Streptomyces lividans protein encoded on the 1 kb TR: Q57094(EMBL:U22894) left direct repeat sequence contained within the amplifiable AUD1 element (336 aa)%2C fasta scores opt: 2173 z-score: 2549.4 E():0 99.4%25 identity in 336 aa overlap. Also highly similar to Streptomyces coelicolor SW:MALR_STRCO (EMBL:Y07706) maltose operon transcriptional repressor%2C MalR or SC10B7.03c (344 aa)%2C fasta scores opt: 1137 z-score: 1336.5 E():0 53.7%25 identity in 341 aa overlap. This gene is duplicated on this cosmid and shares 94%25 identity in a 337 bp overlap with CDS SC1H10.03c. Contains Pfam hits to Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family with the helix-turn-helix motif situated between residues 3..24 (+7.33 SD). gene gene7079 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7016 SCO7017 SCO7017 SC1H10.06c SC1H10.06c 7798420 7799325 - hypothetical protein SC1H10.06c%2C possible membrane protein%2C len: 297 aa. Similar to several including: Streptomyces coelicolor TR:Q9XAL0 (EMBL:AL079348) membrane protein%2C SC66T3.03 (330 aa)%2C fasta scores opt: 561 z-score: 634.9 E(): 6.4e-28 50.8%25 identity in 315 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene7080 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7017 SCO7018 SCO7018 SC1H10.07 SC1H10.07 7800083 7801600 + hypothetical protein SC1H10.07%2C unknown%2C len: 505 aa. gene gene7081 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7018 SCO7019 SCO7019 aml aml 7801756 7804737 - alpha-amylase SC1H10.08c%2C aml%2C alpha-amylase (EC 3.2.1.1)%2C len: 993. Identical to Streptomyces lividans TR:P96992(EMBL:Z86113) alpha-amylase%2C AmlC (993 aa)%2C fasta scores opt: 6792 z-score: 6947.5 E(): 0 99.1%25 identity in 993 aa overlap. Also highly similar to the alpha-amylase domain of Paenibacillus polymyxa (Bacillus polymyxa) SW:AMYB_PAEPO(EMBL:M15817) beta/alpha-amylase precursor (1196 aa)%2C fasta scores opt: 423 z-score: 430.0 E(): 1.6e-16 28.9%25 identity in 956 aa overlap. Contains a Pfam matches to entries PF00128 alpha-amylase%2C Alpha amylase and PF00041 fn3%2C Fibronectin type III domain. Also contains a possible N-terminal signal sequence. gene gene7082 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7019 SCO7020 SCO7020 amlB amlB 7805118 7806638 + alpha-amylase SC1H10.09%2C amlB%2C alpha-amylase (EC 3.2.1.1)%2C len: 506 aa. Highly similar to Streptomyces lividans TR:P97179(EMBL:Z85949) alpha-amylase%2C AmlB (573 aa)%2C fasta scores opt: 3422 z-score: 3742.9 E(): 0 98.6%25 identity in 506 aa overlap and Streptomyces violaceus SW:AMY_STRVL(EMBL:U22894) alpha-amylase precursor (EC 3.2.1.1)%2C (569 aa)%2C fasta scores opt: 2682 z-score: 2933.9 E(): 0 77.1%25 identity in 502 aa overlap. Contains a Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase and a possible N-terminal signal sequence. gene gene7083 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7020 SCO7021 SCO7021 SC1H10.10 SC1H10.10 7807021 7808124 + hypothetical protein SC1H10.10%2C possible hypothetical protein%2C len: 367 aa. Identical over available sequence to Streptomyces lividans TR: Q9ZAK1(EMBL:Y13601) hypothetical 26.8 KD protein (fragment) (250 aa)%2C fasta scores opt: 1497 z-score: 1387.0 E(): 0 96.8%25 identity in 250 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9XAE3(EMBL:AL079356) hypothetical protein%2C SC6G9.39 (391 aa)%2C fasta scores opt: 541 z-score: 507.7 E(): 7.4e-21 40.1%25 identity in 367 aa overlap. Contains a possible N-terminal signal sequence and a Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family. Also contains possible coiled-coils between residues 51..97 and 150..202. gene gene7084 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7021 SCO7022 SCO7022 SC1H10.11 SC1H10.11 7808129 7809061 + hypothetical protein SC1H10.11%2C unknown%2C len: 310 aa. gene gene7085 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7022 SCO7023 SCO7023 SC1H10.12 SC1H10.12 7809224 7810459 + hypothetical protein SC1H10.12%2C unknown%2C len: 411 aa gene gene7086 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7023 SCO7024 SCO7024 SC1H10.13 SC1H10.13 7810502 7811068 + acetyltransferase SC1H10.13%2C possible acetyltransferase%2C len: 188 aa. Weakly similar to several acetyltransferases e.g. Streptomyces coelicolor TR:CAB59477(EMBL:AL132648) acetyltransferase%2C SCI41.07C (196 aa)%2C fasta scores opt: 186 z-score: 237.2 E(): 8.6e-0628.5%25 identity in 165 aa overlap. gene gene7087 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7024 SCO7025 SCO7025 SC1H10.14c SC1H10.14c 7811193 7812095 - LysR family transcriptional regulator SC1H10.14c%2C probable LysR-family transcriptional regulator%2C len: 305 aa. Highly similar to the Streptomyces lividans TR:Q9ZI19 (EMBL:AF043654) LysR-type of transcriptional regulator%2C BxlS (300 aa)%2C fasta scores opt: 1743 z-score: 1937.0 E(): 0 91.0%25 identity in 300 aa overlap. Also similar to many other LysR-family transcriptional regulators e.g. Streptomyces coelicolor TR:O86805 (EMBL:AL031317) transcriptional regulator%2C SC6G4.44 (306 aa)%2C fasta scores opt: 479 z-score: 538.0 E(): 1.5e-22 38.3%25 identity in 300 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins%2C lysR family signature and a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family with the potential helix-turn-helix motif situated between residues 16..37 (+4.86 SD). gene gene7088 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7025 SCO7026 SCO7026 SC1H10.15 SC1H10.15 7812182 7812625 + hypothetical protein SC1H10.15%2C unknown%2C len: 147 aa. Similar to several proteins of unknown function e.g. Bacillus subtilis TR:O32183(EMBL:Z99120) hypothetical protein%2C YusQ (127 aa)%2C fasta scores opt: 227 z-score: 315.9 E(): 3.6e-10 27.9%25 identity in 122 aa overlap. gene gene7089 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7026 SCO7027 SCO7027 SC1H10.16c SC1H10.16c 7812783 7813802 - LacI family transcriptional regulator SC1H10.16c%2C probable LacI-family transcriptional regulator%2C len: 339 aa. Highly similar to Streptomyces lividans TR:Q9ZI18 (EMBL:AF043654) LacI-GalR family regulatory protein%2C BxlR (338 aa)%2C fasta scores opt: 2136 z-score: 2395.5 E(): 0 96.5%25 identity in 340 aa overlap and Escherichia coli SW:CYTR_ECOLI (EMBL:X03683) transcriptional repressor%2C CytR (341 aa)%2C fasta scores opt: 553 z-score: 625.0 E(): 2.2e-27 32.7%25 identity in 330 aa overlap. Also highly similar to Streptomyces coelicolor TR:O86795(EMBL:AL031317) transcriptional regulator%2C SC6G4.32 (355 aa)%2C fasta scores opt: 1318 z-score: 1239.5 E():0 60.2%25 identity in 329 aa overlap. Contains a Prosite hit to PS00356 Bacterial regulatory proteins%2C lacI family signature and Pfam matches to entries PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family and entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family. Also contains a helix-turn-helix motif situated between residues 1..22 (+6.62 SD) gene gene7090 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7027 SCO7028 SCO7028 SC1H10.17 SC1H10.17 7813971 7815275 + sugar-binding lipoprotein SC1H10.17%2C possible sugar-binding lipoprotein%2C len: 434 aa. Identical to Streptomyces lividans TR:Q9Z492 (EMBL:AF043654) sugar-binding protein%2C BxlE (434 aa)%2C fasta scores opt: 2892 z-score: 3295.8 E():0 99.5%25 identity in 434 aa overlap. Also similar to Streptococcus mutans SW:MSME_STRMU(EMBL:M77351) multiple sugar-binding protein precursor%2C MsmE (420 aa)%2C fasta scores opt: 308 z-score: 353.5 E(): 2.9e-12 24.0%25 identity in 383 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein. gene gene7091 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7028 SCO7029 SCO7029 SC1H10.18 SC1H10.18 7815286 7816242 + binding-protein-dependent transport protein SC1H10.18%2C possible binding-protein-dependent transport protein%2C len: 318 aa. Almost identical to Streptomyces lividans TR:Q9ZI17 (EMBL:AF043654) permease%2C BxlF (317 aa)%2C fasta scores opt:2000 z-score: 2320.3 E():0 98.1%25 identity in 318 aa overlap. Also similar to Streptococcus mutans SW:MSMF_STRMU(EMBL:M77351) multiple sugar-binding transport system permease%2C MsmF (290 aa)%2C fasta scores opt: 447 z-score: 524.7 E(): 8.3e-22 29.9%25 identity in 271 aa overlap and Streptomyces coelicolor TR:CAB54176(EMBL:AL110470) binding-protein-dependent transport protein%2C SCF85.19 (300 aa)%2C fasta scores opt: 898 z-score: 1046.1 E():0 44.6%25 identity in 298 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and multiple possible membrane spanning hydrophobic domains. gene gene7092 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7029 SCO7030 SCO7030 SC1H10.19 SC1H10.19 7816239 7817057 + binding-protein-dependent transport protein SC1H10.19%2C possible binding-protein-dependent transport protein%2C len: 310 aa. Almost identical to Streptomyces lividans TR:Q9ZI16 (EMBL:AF043654) permease%2C BxlG (272 aa)%2C fasta scores opt: 1714 z-score: 2067.9 E():0 98.5%25 identity in 272 aa overlap. Also similar to Streptococcus mutans SW:MSMG_STRMU(EMBL:M77351) multiple sugar-binding transport system permease%2C MsmG (277 aa)%2C fasta scores opt: 441 z-score: 537.9 E(): 1.5e-22 28.0%25 identity in 254 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and multiple possible membrane spanning hydrophobic domains. Also contains a possible N-terminal signal sequence. gene gene7093 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7030 SCO7031 SCO7031 SC1H10.20 SC1H10.20 7817054 7819447 + beta-D-xylosidase SC1H10.20%2C beta-D-xylosidase%2C len: 797 aa. Highly similar to Streptomyces lividans TR:Q9ZI15 (EMBL:AF043654) beta-D-xylosidase%2C BxlA (861 aa)%2C fasta scores opt: 4473 z-score: 4774.4 E(): 0 89.2%25 identity in 789 aa overlap. Also highly similar to Streptomyces coelicolor TR:CAB55650(EMBL:AL117385) beta-xylosidase%2C SC5G9.02 (796 aa)%2C fasta scores opt: 4215 z-score: 4499.4 E(): 0 79.1%25 identity in 788 aa overlap. Contains a Pfam matches to entries PF00933 Glyco_hydro_3%2C Glycosyl hydrolase family 3 N terminal domain and Pfam match to entry PF01915 Glyco_hydro_3_C%2C Glycosyl hydrolase family 3 C terminal domain. gene gene7094 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7031 SCO7032 SCO7032 SC1H10.21 SC1H10.21 7819501 7820142 - hypothetical protein SC1H10.21%2C unknown%2C len: 213 aa. Similar to a protein of undefined function from Streptomyces coelicolor TR:Q9XBC6(EMBL:AL078635) hypothetical 22.9 KD protein (205 aa)%2C fasta scores opt: 950 z-score: 1149.9 E(): 0 71.6%25 identity in 201 aa overlap. gene gene7095 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7032 SCO7033 SCO7033 SC1H10.22c SC1H10.22c 7820139 7821806 - regulatory protein SC1H10.22c%2C possible regulatory protein%2C len: 555 aa. Weakly similar to Streptomyces ambofaciens TR:Q00509(EMBL:X63451) polyketide synthase regulatory gene%2C SrmR (604 aa)%2C fasta scores opt: 252 z-score: 283.4 E(): 2.3e-08 27.0%25 identity in 470 aa overlap. Contains helix-turn-helix motif situated between residues 494..515 (+5.41 SD). gene gene7096 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7033 SCO7034 SCO7034 SC1H10.23 SC1H10.23 7821937 7823205 + aminotransferase SC2C3.01%2C probable aminotransferase%2C len: >275 aa%3B similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT%2C 426 aa%3B fasta scores: opt: 634 z-score: 729.2 E(): 0%3B 40.8%25 identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site~SC1H10.23%2C possible aminotransferase%2C partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine aminotranferase (EC 2.6.1.11)%2C ArgD (405 aa)%2C fasta scores opt: 288 z-score:0.0 E(): 0.0 34.44%25 identity in 151 aa overlap. Also similar to many other aminotransferases e.g. Bacillus subtilis SW:GABT_BACSU(EMBL:D50453) probable 4-aminobutyrate aminotransferase (EC 2.6.1.19)%2C fasta scores opt:399 z-score: 483.6 E(): 1.7e-19 36.2%25 identity in 177 aa overlap. Contains a Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate. gene gene7097 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7034 SCO7035 SCO7035 gabD gabD 7823274 7824713 + succinate-semialdehyde dehydrogenase SC2C3.02%2C gabD%2C succinate-semialdehyde dehydrogenase (fragment)%2C len: >422 aa%3B highly similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD%2C 482 aa%3B fasta scores: opt: 1329 z-score: 1466.8 E(): 0%3B 48.9%25 identity in 415 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site~SC4G1.01%2C gabD%2C succinate-semialdehyde dehydrogenase (fragment)%2C len: >90 aa%3B similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD%2C 482 aa%3B fasta scores: opt: 320 z-score: 405.5 E(): 4.1e-15%3B 50.6%25 identity in 87 aa overlap gene gene7098 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7035 SCO7036 SCO7036 argG argG 7824771 7826216 + argininosuccinate synthase catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis gene gene7099 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7036 SCO7037 SCO7037 SC4G1.03 SC4G1.03 7826610 7830005 + hypothetical protein SC4G1.03%2C possible hypothetical protein%2C len: 1131 aa%3B similar to TR:CAB88148 (EMBL:AL352956) Streptomyces coelicolor transmembrane protein SC1H10.04c%2C 1433 aa%3B fasta scores: opt: 1569 z-score: 1600.6 E(): 0%3B 36.4%25 identity in 1265 aa overlap. Contains possible cleavable N-terminal signal peptide sequence gene gene7100 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7037 SCO7038 SCO7038 SC4G1.04c SC4G1.04c 7830042 7832324 - hypothetical protein SC4G1.04c%2C possible integral membrane protein%2C len: 760 aa. Contains possible hydrophobic membrane spanning regions and cleavable N-terminal signal peptide sequence gene gene7101 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7038 SCO7039 SCO7039 SC4G1.05c SC4G1.05c 7832321 7832713 - ABC transporter ATP-binding protein SC4G1.05c%2C possible ABC transport system ATP-binding protein%2C len: 130 aa%3B similar to SW:DPPF_ECOLI (EMBL:L08399) Escherichia coli dipeptide transport ATP-binding protein DppF%2C 334 aa%3B fasta scores: opt: 177 z-score: 195.7 E(): 0.002%3B 42.9%25 identity in 70 aa overlap gene gene7102 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7039 SCO7040 SCO7040 gap2 gap2 7832790 7834235 - glyceraldehyde-3-phosphate dehydrogenase catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate%3B involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium%3B NAD and NADP dependent gene gene7103 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7040 SCO7041 SCO7041 SC4G1.07 SC4G1.07 7834447 7834857 + hypothetical protein SC4G1.07%2C unknown%2C len: 136 aa. High content in alanine%2C leucine and aspartate amino acid residues gene gene7104 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7041 SCO7042 SCO7042 SC4G1.08c SC4G1.08c 7834891 7835298 - MarR family transcriptional regulator SC4G1.08c%2C probable marR-family transcriptional regulator%2C len: 135 aa%3B similar to TR:Q9X8V0 (EMBL:AL049826) Streptomyces coelicolor transcriptional regulator SCH24.36c%2C 154 aa%3B fasta scores: opt: 252 z-score: 343.3 E(): 1.2e-11%3B 36.2%25 identity in 127 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and match to Prosite entry PS01117 Bacterial regulatory proteins%2C marR family signature. Also contains possible helix-turn-helix motif at residues 59..80 (+2.64 SD) gene gene7105 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7042 SCO7043 SCO7043 SC4G1.09 SC4G1.09 7835383 7835715 + hypothetical protein SC4G1.09%2C unknown%2C len: 110 aa. Highly hydrophilic gene gene7106 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7043 SCO7044 SCO7044 ccrB ccrB 7835928 7836392 + camphor resistance protein CrcB may be involved in chromosome condensation%3B overexpression in Escherichia coli protects against decondensation by camphor%3B overexpressing the protein results in an increase in supercoiling gene gene7107 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7044 SCO7045 SCO7045 SC4G1.11 SC4G1.11 7836389 7836733 + hypothetical protein SC4G1.11%2C hypothetical protein%2C len: 114 aa%3B similar to TR:O59172 (EMBL:AP000006) Pyrococcus horikoshii hypothetical 14.9 kDa protein PH1503%2C 130 aa%3B fasta scores: opt: 302 z-score: 405.0 E(): 4.3e-15%3B 41.0%25 identity in 100 aa overlap gene gene7108 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7045 SCO7046 SCO7046 ccrB ccrB 7836730 7837104 + camphor resistance protein CrcB may be involved in chromosome condensation%3B overexpression in Escherichia coli protects against decondensation by camphor%3B overexpressing the protein results in an increase in supercoiling gene gene7109 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7046 SCO7047 SCO7047 uppP uppP 7837144 7837980 + UDP pyrophosphate phosphatase BacA%3B phosphatase activity in Escherichia coli not kinase%3B involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell gene gene7110 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7047 SCO7048 SCO7048 SC4G1.14c SC4G1.14c 7838003 7839046 - delta fatty acid desaturase SC4G1.14c%2C probable delta fatty acid desaturase%2C len: 347 aa%3B similar to TR:Q9X8W4 (EMBL:AL078610) Streptomyces coelicolor delta fatty acid desaturase SCH35.42c%2C 345 aa%3B fasta scores: opt: 1352 z-score: 1620.0 E(): 0%3B 60.1%25 identity in 343 aa overlap and to TR:Q9ZNW2 (EMBL:AJ22298) Physcomitrella patens delta 6-acyl-lipid desaturase Des6%2C 525 aa%3B fasta scores: opt: 425 z-score: 510.0 E(): 6.1e-21%3B 31.5%25 identity in 352 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7111 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7048 SCO7049 SCO7049 SC4G1.15 SC4G1.15 7839207 7840130 + glutaminase catalyzes the formation of glutamate from glutamine gene gene7112 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7049 SCO7050 SCO7050 SC4G1.16c SC4G1.16c 7840162 7841403 - D-alanyl-D-alanine carboxypeptidase SC4G1.16c%2C probable D-alanyl-D-alanine carboxypeptidase%2C len: 413 aa%3B similar to TR:CAB89066 (EMBL:AL353872) Streptomyces coelicolor D-alanyl-D-alanine carboxypeptidase SC5G8.15c%2C 424 aa%3B fasta scores: opt: 704 z-score: 719.2 E(): 1.4e-32%3B 47.7%25 identity in 390 aa overlap and to SW:DACF_BACSU (EMBL:M85047) Bacillus subtilis penicillin-binding protein DacF precursor%2C 389 aa%3B fasta scores: opt: 330 z-score: 341.5 E(): 1.5e-11%3B 27.1%25 identity in 262 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11%2C D-alanyl-D-alanine carboxypeptidase gene gene7113 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7050 SCO7051 SCO7051 rho rho 7841463 7842710 - transcription termination factor Rho An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes gene gene7114 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7051 SCO7052 SCO7052 SC4G1.18c SC4G1.18c 7842905 7843300 - hypothetical protein SC4G1.18c%2C unknown%2C len: 131 aa gene gene7115 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7052 SCO7053 SCO7053 SC4G1.19c SC4G1.19c 7843684 7844103 - hypothetical protein SC4G1.19c%2C hypothetical protein%2C len: 139 aa%3B similar to TR:O33283 (EMBL:AL008967) Mycobacterium tuberculosis hypothetical 16.6 kD protein%2C 149 aa%3B fasta scores: opt: 118 z-score: 161.0 E(): 0.17%3B 34.2%25 identity in 79 aa overlap gene gene7116 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7053 SCO7054 SCO7054 SC4G1.20 SC4G1.20 7844184 7844771 + hypothetical protein SC4G1.20%2C conserved hypothetical protein%2C len: 195 aa%3B similar to TR:Q9X399 (EMBL:AF06544) Vibrio cholerae hypothetical 20.4 kD protein AphA%2C 179 aa%3B fasta scores: opt: 313 z-score: 386.3 E(): 4.8e-14%3B 32.4%25 identity in 185 aa overlap gene gene7117 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7054 SCO7055 SCO7055 SC4G1.21 SC4G1.21 7844776 7845501 + methyltransferase SC4G1.21%2C possible methyltransferase%2C len: 241 aa%3B similar to TR:P72459 (EMBL:Y08763) Streptomyces griseus methyltransferase StsG%2C 253 aa%3B fasta scores: opt: 207 z-score: 238.8 E(): 7.8e-06%3B 34.1%25 identity in 138 aa overlap gene gene7118 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7055 SCO7056 SCO7056 SC4G1.22c SC4G1.22c 7845511 7846272 - GntR family transcriptional regulator SC4G1.22c%2C possible gntR-family transcriptional regulator%2C len: 253 aa%3B similar to TR:Q9RYU6 (EMBL:AE001863) Deinococcus radiodurans transcriptional regulator%2C gntR-family DRA0211%2C 279 aa%3B fasta scores: opt: 217 z-score: 236.0 E(): 1.1e-05%3B 37.6%25 identity in 141 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and match to Prosite entry PS00043 Bacterial regulatory proteins%2C gntR family signature. Also contains a possible helix-turn-helix at residues 47..68 (+4.70 SD) gene gene7119 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7056 SCO7057 SCO7057 SC4G1.23c SC4G1.23c 7846397 7847365 - esterase SC4G1.23c%2C possible esterase%2C len: 322 aa%3B similar to TR:O33842 (EMBL:U58632) Thermotoga neapolitana acetyl xylan esterase AxeA%2C 325 aa%3B fasta scores: opt: 1173 z-score: 1264.6 E(): 0%3B 54.2%25 identity in 321 aa overlap gene gene7120 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7057 SCO7058 SCO7058 SC4G1.24c SC4G1.24c 7847483 7848067 - hypothetical protein SC4G1.24c%2C possible integral membrane protein%2C len: 194 aa%3B similar to TR:Q9RIY8 (EMBL:AL109962) Streptomyces coelicolor hypothetical 20.8 kD protein SCJ1.26%2C 193 aa%3B fasta scores: opt: 412 z-score: 478.0 E(): 3.7e-19%3B 38.8%25 identity in 183 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7121 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7058 SCO7059 SCO7059 SC4G1.25c SC4G1.25c 7848220 7848921 - oxidoreductase SC4G1.25c%2C possible oxidoreductase%2C len: 233 aa%3B similar to TR:Q51492 (EMBL:D84146) Pseudomonas aeruginosa reductase PahA%2C 328 aa%3B fasta scores: opt: 297 z-score: 346.1 E(): 8.3e-12%3B 32.0%25 identity in 203 aa overlap gene gene7122 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7059 SCO7060 SCO7060 SC4G1.26c SC4G1.26c 7848995 7849600 - hypothetical protein SC4G1.26c%2C conserved hypothetical protein%2C len: 201 aa%3B similar to TR:Q9S2N1 (EMBL:AL109661) Streptomyces coelicolor hypothetical 24.3 kDa protein SC6E10.06c%2C 215 aa%3B fasta scores: opt: 540 z-score: 638.3 E(): 4.4e-28%3B 42.9%25 identity in 198 aa overlap gene gene7123 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7060 SCO7061 SCO7061 SC4G1.27c SC4G1.27c 7849651 7850187 - MarR family transcriptional regulator SC4G1.27c%2C probable marR-family transcriptional regulator%2C len: 178 aa%3B similar to SW:YXAD_BACSU (EMBL:AB005554) Bacillus subtilis hypothetical transcriptional regulator in AsnH-GntR intergenic region YxaD%2C 143 aa%3B fasta scores: opt: 242 z-score: 315.6 E(): 4.1e-10%3B 36.4%25 identity in 132 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and possible helix-turn-helix motif at residues 65..86 (+3.24 SD) gene gene7124 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7061 SCO7062 SCO7062 SC4G1.28 SC4G1.28 7850449 7851291 + methylase SC4G1.28%2C possible methylase%2C len: 280 aa%3B similar to TR:P72542 (EMBL:U60417) Streptomyces pristinaespiralis PapM%2C 292 aa%3B fasta socres: opt: 401 z-score: 442.7 E(): 3.4e-17%3B 35.2%25 identity in 264 aa overlap and to SW:HEMK_ECOLI (EMBL:D28567) Escherichia coli HemK protein%2C 277 aa%3B fasta scores: opt: 299 z-score: 332.7 E(): 4.6e-11%3B 32.3%25 identity in 254 aa overlap gene gene7125 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7062 SCO7063 SCO7063 SC4G1.29c SC4G1.29c 7851281 7853389 - hypothetical protein SC4G1.29c%2C conserved hypothetical protein%2C len: 702 aa%3B similar to TR:Q9RJC6 (EMBL:AL133171) Streptomyces coelicolor hypothetical 89.7 kDa protein SCF81.26%2C 835 aa%3B fasta scores: opt: 1037 z-score: 1100.0 E(): 0%3B 40.3%25 identity in 683 aa overlap. Contains 3x Pfam matches to entry PF00989 PAS%2C PAS domain%2C Pfam match to entry PF01590 GAF%2C GAF domain gene gene7126 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7063 SCO7064 SCO7064 SC4G1.30 SC4G1.30 7853666 7854562 + hypothetical protein SC4G1.30%2C possible hypothetical protein%2C len: 298 aa. Contains possible N-terminal region signal peptide sequence%2C possibly cleavable gene gene7127 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7064 SCO7065 SCO7065 SC4G1.31 SC4G1.31 7854655 7855026 + hypothetical protein SC4G1.31%2C conserved hypothetical protein%2C len: 123 aa%3B similar to TR:Q9X7R3 (EMBL:AL049863) Streptomyces coelicolor hypothetical 11.4 kDa protein SC5H1.05%2C 117 aa%3B fasta scores: opt: 153 z-score: 212.5 E(): 0.00023%3B 37.1%25 identity in 116 aa overlap gene gene7128 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7065 SCO7066 SCO7066 fadH fadH 7855137 7857152 + 2%2C4-dienoyl-CoA reductase SC4G1.32%2C fadH%2C 2%2C4-dienoyl-CoA reductase [NADPH]%2C len: 671 aa%3B highly similar to SW:FADH_ECOLI (EMBL:U93405) Escherichia coli 2%2C4-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34) FadH%2C 671 aa%3B fasta scores: opt: 2871 z-score: 3039.3 E(): 0%3B 62.8%25 identity in 667 aa overlap. Contains Pfam match to entry PF00724 oxidored_FMN%2C NADH:flavin oxidoreductase / NADH oxidase family gene gene7129 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7066 SCO7067 SCO7067 SC4G1.33 SC4G1.33 7857217 7857768 + hypothetical protein SC4G1.33%2C hypothetical protein%2C len: 183 aa%3B similar to TR:Q9X399 (EMBL:AF065442) Vibrio cholerae hypothetical 20.4 kDa protein AphA%2C 179 aa%3B fasta scores: opt: 392 z-score: 485.9 E(): 1.3e-19%3B 35.4%25 identity in 178 aa overlap gene gene7130 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7067 SCO7068 SCO7068 SC4G1.34c SC4G1.34c 7857789 7858376 - hypothetical protein SC4G1.34c%2C possible hypothetical protein%2C len: 183 aa%3B similar to TR:CAB69767 (EMBL:AL137187) Streptomyces coelicolor hypothetical protein SC7A8.18%2C 180 aa%3B fasta scores: opt: 171 z-score: 179.1 E(): 0.017%3B 32.8%25 identity in 192 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7131 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7068 SCO7069 SCO7069 SC4G1.35c SC4G1.35c 7858527 7859510 - hydrolase SC4G1.35c%2C possible hydrolase%2C len: 327 aa%3B similar to SW:GUXB_CELFI (EMBL:L38827) Cellulomonas fimi exoglucanase B precursor (EC 3.2.1.91) CbhB%2C 1090 aa%3B fasta scores: opt: 384 z-score: 407.1 E(): 3.3e-15%3B 33.9%25 identity in 292 aa overlap and to TR:O54183 (EMBL:AL021411) Streptomyces coelicolor chitinase SC7H1.24%2C 765 aa%3B fasta scores: opt: 416 z-score: 443.1 E(): 3.2e-17%3B 40.3%25 identity in 201 aa overlap. Contains 2x Pfam matches to entry PF00041 fn3%2C Fibronectin type III domain and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene7132 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7069 SCO7070 SCO7070 SC4G1.36 SC4G1.36 7859605 7860771 + hypothetical protein SC4G1.36%2C unknown%2C len: 388 aa. High content in alanine%2C arginine%2C glycine and proline amino acid residues. Also contains TTA leucine codon%2C possible target for bldA regulation gene gene7133 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7070 SCO7071 SCO7071 SC4G1.37c SC4G1.37c 7860829 7861221 - hypothetical protein SC4G1.37c%2C conserved hypothetical protein%2C len: 130 aa%3B similar to TR:Q9RZR3 (EMBL:AE001826) Deinococcus radiodurans conserved hypothetical protein DRB0052%2C 133 aa%3B fasta scores: opt: 250 z-score: 278.2 E(): 5e-08%3B 42.2%25 identity in 135 aa overlap gene gene7134 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7071 SCO7072 SCO7072 SC4G1.38c SC4G1.38c 7861232 7861831 - hypothetical protein SC4G1.38c%2C hypothetical protein%2C len: 199 aa%3B similar to SW:YCGS_ECOLI (EMBL:AE000218) Escherichia coli hypothetical 22.6 kDa protein in TreA-Pth intergenic region YcgS%2C 210 aa%3B fasta scores: opt: 349 z-score: 387.3 E(): 4.2e-14%3B 44.5%25 identity in 200 aa overlap and to C-terminal region of SW:DAK1_YEAST (EMBL:Z38114) Saccharomyces cerevisiae dihydroxyacetone kinase 1 (EC 2.7.1.29) Dak1%2C 584 aa%3B fasta scores: opt: 298 z-score: 326.4 E(): 1e-10%3B 33.3%25 identity in 189 aa overlap gene gene7135 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7072 SCO7073 SCO7073 SC4G1.39c SC4G1.39c 7861881 7862873 - dihydroxyacetone kinase subunit DhaK with DhaL and DhaM forms dihydroxyacetone kinase%2C which is responsible for phosphorylating dihydroxyacetone%3B DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase gene gene7136 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7073 SCO7074 SCO7074 SC4G1.40 SC4G1.40 7863191 7863367 + hypothetical protein SC4G1.40%2C possible membrane protein%2C len: 58 aa%3B similar to C-terminal region of TR:P96360 (EMBL:Z92539) Mycobacterium tuberculosis hypothetical 31.4 kDa protein%2C MTCY10G2.08 aa%3B fasta scores: opt: 213 z-score: 335.7 E(): 3.1e-11%3B 65.3%25 identity in 49 aa overlap. Contains possible hydrophobic membrane spanning region gene gene7137 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7074 SCO7075 SCO7075 SC3A4.01 SC3A4.01 7863791 7864483 + two component response regulator protein SC3A4.01%2C two component response regulator protein%2C len: 230 aa. Highly similar to Pseudomonas syringae (pv. tomato) SW:COPR_PSESM (EMBL:L05176) transcriptional activator of copper resistance operon%2C CopR (227 aa) fasta scores%2C opt: 549 z-score: 653.7 E(): 5.9e-29 41.8%25 identity in 225 aa overlap and Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2)SW:SPHR_SYNP7(EMBL%3B D13172) response regulator of alkaline phosphatase%2C SphR (257 aa) fasta scores%2C opt: 554 z-score: 658.8 E(): 3.1e-29 40.8%25 identity in 233 aa overlap. Also similar to Streptomyces coelicolor SCD84.24c (248 aa)%2C fasta scores opt: 767 z-score: 776.3 E():0 51.7%25 identity in 238 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and a Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal. gene gene7138 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7075 SCO7076 SCO7076 SC3A4.02 SC3A4.02 7864480 7865931 + two-component histidine kinase SC3A4.02%2C two-component histidine kinase%2C len: 483 aa. Similar in parts to Agrobacterium tumefaciens SW:CHVG_AGRTU(EMBL:L18860) two-component histidine kinase required for virulence (690 aa)%2C fasta scores%2C opt:399 z-score: 426.8 E(): 2.6e-16 33.1%25 identity in 357 aa overlap. Also similar to Streptomyces coelicolor SCD84.23c (481 aa)%2C fasta scores opt: 874 z-score: 748.4 E():0 39.8%25 identity in 480 aa overlap. Contains a Pfam match to entry PF00672 DUF5%2C Domain found in bacterial signal proteins and a Pfam match to entry PF00512 signal%2C Histidine kinase. Contains probable membrane-spanning domain gene gene7139 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7076 SCO7077 SCO7077 SC3A4.03c SC3A4.03c 7866148 7868298 - hypothetical protein SC3A4.03c%2C membrane protein len: 716 aa. Similar to multiple membrane proteins e.g. Streptomyces coelicolor SW:MMLA_STRCO(EMBL:M64683) membrane protein ActII-3 in the actinorhodin biosynthetic region (711 aa) fasta scores%2C opt: 1747 z-score: 1956.0 E():0 43.0%25 identity in 702 aa overlap. Contains probable membrane-spanning domains. gene gene7140 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7077 SCO7078 SCO7078 SC3A4.04c SC3A4.04c 7868683 7869120 - insertion element transposase (fragment) SC3A4.04c%2C possible insertion element transposase (fragment)%2C partial CDS%2C len: 145 aa. Similar to many transposases e.g. Streptomyces coelicolor TR:O69846(EMBL:AL023702) insertion element IS1647 transposase%2C SC1C3.04 (119 aa)%2C fasta scores opt: 340 z-score: 423.5 E(): 3.9e-16 44.1%25 identity in 111 aa overlap. Contains a Pfam match to entry PF01511 Transposase_6%2C Transposase. gene gene7141 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7078 SCO7079 SCO7079 SC3A4.05 SC3A4.05 7869233 7869625 + gene gene7142 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7079 SCO7080 SCO7080 SC3A4.06c SC3A4.06c 7869683 7870519 - insertion element transposase SC3A4.06c%2C possible insertion element transposase%2C len: 278 aa. Weakly similar to several transposases e.g. Fremyella diplosiphon SW:TRA2_FREDI(EMBL:X60384) probable transposase for insertion sequence element IS702 (276 aa)%2C fasta scores opt: 147 z-score: 180.3 E(): 0.014 23.3%25 identity in 240 aa overlap. Contains a helix-turn-helix motif situated between residues 50..71 (+3.28 SD). Contains a TTA/leucine codon%2C possible target for bldA regulation. gene gene7143 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7080 SCO7081 SCO7081 SC3A4.07c SC3A4.07c 7870734 7871921 - phospholipase SC3A4.07c%2C possible phospholipase%2C len: 395 aa. Similar to several including: Bacillus firmus TR:O66043(EMBL:U88888) cardiolipin synthase%2C ClS (503 aa)%2C fasta scores opt: 605 z-score: 748.2 E():0 31.8%25 identity in 377 aa overlap. Contains 2xPfam matches to entry PF00614 PLDc%2C Phospholipase D. Active site motif. gene gene7144 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7081 SCO7082 SCO7082 SC3A4.08c SC3A4.08c 7872043 7872507 - hypothetical protein SC3A4.08c%2C doubtful CDS%2C len: 154 aa. gene gene7145 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7082 SCO7083 SCO7083 SC3A4.09c SC3A4.09c 7872697 7872801 - insertion element transposase (fragment) SC3A4.09c%2C possible insertion element transposase (fragment)%2C partial CDS%2C len: 35 aa. Similar to Streptomyces coelicolor TR:CAB52966(EMBL:AL109950) transposase%2C SCJ4.32c (59 aa)%2C fasta scores opt:100 z-score: 199.9 E(): 0.0011 60.9%25 identity in 23 aa overlap. gene gene7146 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7083 SCO7084 SCO7084 SC3A4.10 SC3A4.10 7872834 7872977 + hypothetical protein SC3A4.10%2C doubtful CDS%2C len: 47 aa. gene gene7147 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7084 SCO7085 SCO7085 SC3A4.11 SC3A4.11 7873167 7873427 + hypothetical protein SC3A4.11%2C doubtful CDS%2C len: 86 aa. gene gene7148 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7085 SCO7086 SCO7086 SC3A4.12c SC3A4.12c 7873600 7873947 - MerR family transcriptional regulator SC3A4.12c%2C possible MerR-family transcriptional regulator%2C len: 115 aa. Similar to many regulators including: Thiobacillus ferrooxidans SW:MERR_THIFE (EMBL:M57717) mercuric resistance operon regulatory protein (fragment) (122 aa)%2C fasta scores opt: 166 z-score: 229.9 E(): 2.4e-05 33.0%25 identity in 106 aa overlap. Conatins a Prosite hit to PS00552 Bacterial regulatory proteins%2C merR family signature and a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family with a helix-turn-helix motif situated between residues 4..25 (+4.59 SD). gene gene7149 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7086 SCO7087 SCO7087 SC3A4.13c SC3A4.13c 7873970 7874908 - oxidoreductase SC3A4.13c%2C possible oxidoreductase%2C len: 312 aa. Similar to many including: Streptomyces coelicolor TR:CAB61562(EMBL:AL133171) aldo/keto reductase (fragment)%2C SCF81.28C (307 aa)%2C fasta scores opt: 351 z-score: 407.7 E():3e-15 30.7%25 identity in 309 aa overlap. gene gene7150 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7087 SCO7088 SCO7088 SC3A4.14c SC3A4.14c 7875374 7876051 - two-component system response regulator SC3A4.14c%2C two-component system response regulator%2C len: 225 aa. Similar to Escherichia coli SW:NARL_ECOLI(EMBL:X13360) nitrate/nitrite response regulator protein%2C NarL (216 aa)%2C fasta scores opt: 375 z-score:0.0 E(): 0.0 33.79%25 identity in 219 aa overlap. Also highly similar to multiple Streptomyces coelicolor two-component response regulators e.g. TR:CAB59718(EMBL:AL132707) SCF51.20C (219 aa)%2C fasta scores opt: 933 z-score: 1109.1 E():0 73.3%25 identity in 217 aa overlap. Contains a Prosite hits to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains Pfam matches to entries PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and PF00072 response_reg%2C Response regulator receiver domain with the helix-turn-helix motif situated between residues 174..195 (+3.75 SD). gene gene7151 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7088 SCO7089 SCO7089 SC3A4.15c SC3A4.15c 7876048 7877241 - two-component system sensor kinase SC3A4.15c%2C probable two-component system sensor kinase%2C len: 397 aa. Highly similar to many including Escherichia coli SW:NARX_ECOLI (EMBL:X13360) nitrate/nitrite sensor protein NarX (598 aa)%2C fasta scores opt: 211 z-score:0.0 E(): 0.0 28.82%25 identity in 229 aa overlap and Streptomyces coelicolor TR:CAB59719 (EMBL:AL132707) two-component sensor kinase%2C SCF51.21C (397 aa)%2C fasta scores opt: 1075 z-score: 1237.2 E(): 0 48.0%25 identity in 400 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene7152 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7089 SCO7090 SCO7090 SC3A4.16c SC3A4.16c 7877335 7879581 - hypothetical protein SC3A4.16c%2C possible integral membrane protein%2C len: 748 aa. Highly similar to several including: Streptomyces coelicolor TR:CAB59662(EMBL:AL132674) integral membrane transport protein%2C SCE87.17C (745 aa)%2C fasta scores opt: 2918 z-score: 3028.3 E():0 61.8%25 identity in 744 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7153 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7090 SCO7091 SCO7091 SC3A4.17c SC3A4.17c 7879864 7880010 - hypothetical protein SC3A4.17c%2C doubtful CDS%2C len: 48 aa. Contains a TTA/leucine codon%2C possible target for bldA regulation. gene gene7154 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7091 SCO7092 SCO7092 SC3A4.18 SC3A4.18 7880228 7881130 + hypothetical protein SC3A4.18%2C possible hypothetical protein%2C len: 300 aa. Contains a possible N-terminal signal sequence. Contains a TTA/leucine codon%2C possible target for bldA regulation gene gene7155 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7092 SCO7093 SCO7093 SC3A4.19 SC3A4.19 7881841 7884639 + transcriptional regulator SC3A4.19%2C possible transcriptional regulator%2C len: 932 aa. Highly similar to several including Streptomyces albus TR:Q53582(EMBL:U03114) transcriptional activator of the LipA promoter%2C LipR (890 aa)%2C fasta scores opt: 714 z-score: 762.7 E(): 0 30.3%25 identity in 922 aa overlap and Streptomyces coelicolor TR:CAB52359(EMBL:AL109747) probable transcriptional regulator%2C SCJ21.13 (919 aa)%2C fasta scores opt: 2398 z-score: 2564.6 E(): 0 48.0%25 identity in 911 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family with the helix-turn-helix motif situated between residues 883..904 (+3.20 SD). gene gene7156 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7093 SCO7094 SCO7094 hmpA2 hmpA2 7884751 7885962 - flavohemoprotein SC3A4.20c%2C hmpA2%2C flavohemoprotein (hemoglobin-like protein)%2C len: 403 aa. Highly similar to many including: Escherichia coli SW:HMPA_ECOLI (EMBL:X58872) flavohemoprotein%2C HmpA (396 aa)%2C fasta scores: opt: 833 z-score: 947.5 E():0 37.9%25 identity in 406 aa overlap and Streptomyces coelicolor TR:CAB76347 (EMBL:AL158061) flavohemoprotein%2C HmpA1 or SC6D11.24 (398 aa)%2C fasta scores: opt: 1706 z-score: 1936.1 E(): 0 65.3%25 identity in 404 aa overlap. contains Pfam matches to entries PF00175 oxidored_fad%2C Oxidoreductase FAD/NAD-binding domain and PF00042 globin%2C Globin. gene gene7157 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7094 SCO7095 SCO7095 SC3A4.21c SC3A4.21c 7886126 7887082 - hydrolase SC3A4.21c%2C possible hydrolase. len: 318 aa. Similar in parts to several e.g. Moraxella sp. SW:DEH1_MORSP(EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa)%2C fasta scores opt: 245 z-score: 286.4 E(): 1.7e-08 37.4%25 identity in 131 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene7158 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7095 SCO7096 SCO7096 SC3A4.22 SC3A4.22 7887321 7887665 + hypothetical protein SC3A4.22%2C possible membrane protein%2C len: 114 aa. Contains a possible membrane spanning hydrophobic domain. gene gene7159 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7096 SCO7097 SCO7097 SC3A4.23c SC3A4.23c 7887694 7888284 - MarR family regulatory protein SC3A4.23c%2C possible MarR-family regulator protein%2C len: 196 aa. Similar to several including: Erwinia chrysanthemi SW:PECS_ERWCH (EMBL:X74409) regulatory protein%2C PecS (166 aa)%2C fasta scores opt: 359 z-score: 425.8 E(): 2.9e-16 38.8%25 identity in 170 aa overlap and Streptomyces coelicolor TR:CAB71822 (EMBL:AL138662) MarR-family regulatory protein%2C SC8E4A.17 (172 aa)%2C fasta scores opt: 359 z-score: 425.8 E(): 2.9e-16 38.8%25 identity in 170 aa overlap. Contains a Pfam match to entry PF01047 MarR%2C MarR family. gene gene7160 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7097 SCO7098 SCO7098 SC3A4.24c SC3A4.24c 7888577 7889113 - hypothetical protein SC3A4.24c%2C unknown%2C len: 178 aa. Weakly similar to another hypothetical protein from Streptomyces coelicolor: TR:CAB52889(EMBL:AL109949) SCJ11.04 (195 aa)%2C fasta scores opt: 122 z-score: 143.6 E(): 1.5 29.2%25 identity in 154 aa overlap. Contains a possible coiled-coil region between residues 28..57. gene gene7161 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7098 SCO7099 SCO7099 SC3A4.25c SC3A4.25c 7889266 7890168 - RNA polymerase sigma factor SC3A4.25c%2C possible RNA polymerase sigma factor%2C len: 300 aa. Similar to many sigma factors from Streptomyces coelicolor e.g. TR:CAB60158 (EMBL:AL132824) SCAH10.04C (322 aa)%2C fasta scores opt: 427 z-score: 505.7 E(): 1e-20 36.5%25 identity in 307 aa overlap and TR:CAB59711 (EMBL:AL132707) SCF51.13C (298 aa)%2C fasta scores opt: 445 z-score: 527.2 E(): 6.6e-22 38.6%25 identity in 298 aa overlap. gene gene7162 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7099 SCO7100 SCO7100 SC4B10.01 SC4B10.01 7890426 7891208 + oxidoreductase SC4B10.01%2C probable oxidoreductase%2C len: 260 aa%3B similar to TR:Q9RK83 (EMBL:AL132662) Streptomyces coelicolor possible oxidoreductase SCF11.06%2C 277 aa%3B fasta scores: opt: 208 z-score: 258.9 E(): 5.9e-07%3B 25.5%25 identity in 243 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold gene gene7163 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7100 SCO7101 SCO7101 SC4B10.02 SC4B10.02 7891305 7892660 + dehydrogenase SC4B10.02%2C probable dehydrogenase%2C len: 451 aa%3B similar to SW:DHNA_ECOLI (EMBL:V00306) Escherichia coli NADH dehydrogenase (EC 1.6.99.3) Ndh%2C 433 aa%3B fasta scores: opt: 472 z-score: 552.4 E(): 2.7e-23%3B 31.6%25 identity in 377 aa overlap gene gene7164 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7101 SCO7102 SCO7102 SC4B10.03c SC4B10.03c 7892704 7893258 - hypothetical protein SC4B10.03c%2C conserved hypothetical protein%2C len: 184 aa%3B similar to TR:CAB89770 (EMBL:AL354616) Streptomyces coelicolor hypothetical 19.1 kD protein SC3A4.24c%2C 178 aa%3B fasta scores: opt: 394 z-score: 403.2 E(): 5.4e-15%3B 55.5%25 identity in 182 aa overlap. Contains a coiled-coil region at approx. residues 18..45 gene gene7165 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7102 SCO7103 SCO7103 SC4B10.04c SC4B10.04c 7893453 7893752 - hypothetical protein SC4B10.04c%2C unknown%2C len: 99 aa. Highly hydrophilic. Contains a possible coiled-coil regions at approx%2C residues 41..59 gene gene7166 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7103 SCO7104 SCO7104 SC4B10.05 SC4B10.05 7894195 7895073 + RNA polymerase sigma factor SC4B10.05%2C possible RNA polymerase sigma factor%2C len: 292 aa%3B similar to TR:CAB89771 (EMBL:AL354616) Streptomyces coelicolor RNA polymerase sigma factor SC3A4.25c%2C 300 aa%3B fasta scores: opt: 901 z-score: 941.4 E(): 0%3B 51.7%25 identity in 290 aa overlap gene gene7167 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7104 SCO7105 SCO7105 SC4B10.06c SC4B10.06c 7895116 7896021 - RNA polymerase sigma factor SC4B10.06c%2C possible RNA polymerase sigma factor%2C len: 301 aa%3B similar to TR:Q9S1V5 (EMBL:AL109950) Streptomyces coelicolor sigma factor SCJ24.18c%2C 250 aa%3B fasta scores: opt: 877 z-score: 1049.7 E(): 0%3B 54.7%25 identity in 236 aa overlap and to Streptomyces coelicolor St4B10.13c%2C 298%3B fasta scores: opt: 1112 z-score: 1131.2 E(): 0%3B 57.3%25 identity in 288 aa overlap. Also contains a possible helix-turn-helix motif at residues 133..154 (+3.38 SD) gene gene7168 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7105 SCO7106 SCO7106 SC4B10.07 SC4B10.07 7896424 7896690 + hypothetical protein SC4B10.07%2C conserved hypothetical protein%2C len: 88 aa%3B similar to TR:Q9X952 (EMBL:AJ239087) Streptomyces coelicolor hypothetical 9.7 kDa protein WblE%2C 85 aa%3B fasta scores: opt: 382 z-score: 525.6 E(): 8.3e-22%3B 59.1%25 identity in 88 aa overlap and to TR:CAB93744 (EMBL:AL357613) Streptomyces coelicolor regulatory protein SC5F8.16c%2C 83 aa%3B fasta scores: opt: 368 z-score: 507.1 E(): 8.8e-21%3B 61.9%25 identity in 84 aa overlap gene gene7169 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7106 SCO7107 SCO7107 SC4B10.08c SC4B10.08c 7896813 7897409 - hypothetical protein SC4B10.08c%2C conserved hypothetical protein%2C len: 198 aa%3B similar to TR:O86515 (EMBL:AL031124) Streptomyces coelicolor hypothetical 20.0 kDa protein SC1C2.14c%2C 185 aa%3B fasta scores: opt: 698 z-score: 894.2 E(): 0%3B 56.9%25 identity in 174 aa overlap gene gene7170 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7107 SCO7108 SCO7108 SC4B10.09c SC4B10.09c 7897518 7898264 - hypothetical protein SC4B10.09c%2C conserved hypothetical protein%2C len: 248 aa%3B similar to TR:Q9S1U9 (EMBL:AL109950) Streptomyces coelicolor hypothetical 25.2 kD protein SCJ4.24c%2C 242 aa%3B fasta scores: opt: 725 z-score: 841.0 E(): 0%3B 47.8%25 identity in 245 aa overlap%2C to TR:CAC01591 (EMBL:AL391041) Streptomyces coelicolor hypothetical protein SC8A11.19c%2C 269 aa%3B fasta scores: opt: 1213 z-score: 1236.7 E(): 0%3B 74.2%25 identity in 248 aa overlap and to TR:Q98LL5 (EMBL:AP002996) Rhizobium loti MLR0977 protein%2C 252 aa%3B fasta scores: opt: 944 Z-score: 1074.9 E(): 3.1e-52%3B 58.607%25 identity in 244 aa overlap gene gene7171 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7108 SCO7109 SCO7109 SC4B10.10c SC4B10.10c 7898419 7900149 - oxidoreductase SC4B10.10c%2C possible oxidoreductase%2C len: 576 aa%3B similar to TR:O27546 (EMBL:AE000910) Methanobacterium thermoautotrophicum succinate dehydrogenase%2C flavoprotein subunit MTH1502%2C 558 aa%3B fasta scores: opt: 1262 z-score: 1392.4 E(): 0%3B 41.0%25 identity in 542 aa overlap and to TR:O53141 (EMBL:AJ000941) Methanobacterium thermoautotrophicum strain marburg%2C thiol:fumarate reductase subunit A Tfr%2C 545 aa%3B fasta scores: opt: 1184 z-score: 1306.6 E(): 0%3B 40.5%25 identity in 536 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2%2C FAD binding domain gene gene7172 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7109 SCO7110 SCO7110 fdxA fdxA 7900323 7900712 + ferredoxin SC4B10.11%2C fdxA%2C ferredoxin%2C len: 129 aa%3B highly similar to SW:FER_STRGR (EMBL:S08287) Streptomyces griseus ferredoxin 7Fe%2C 105 aa%3B fasta scores: opt: 510 z-score: 644.4 E(): 2e-28%3B 64.4%25 identity in 104 aa overlap. Contains Pfam match to entry PF00037 fer4%2C 4Fe-4S binding domain and match to Prosite entry PS00190 Cytochrome c family heme-binding site signature and PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene7173 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7110 SCO7111 SCO7111 SC4B10.12c SC4B10.12c 7900740 7901153 - hydroperoxide resistance protein SC4B10.12c%2C probable hydroperoxide resistance protein%2C len: 137 aa%3B similar to SW:OHR_XANCH (EMBL:AF036166) Xanthomonas campestris organic hydroperoxide resistance protein Ohr%2C 142 aa%3B fasta scores: opt: 341 z-score: 437.5 E(): 6.6e-17%3B 47.1%25 identity in 138 aa overlap gene gene7174 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7111 SCO7112 SCO7112 SC4B10.13c SC4B10.13c 7901360 7902256 - ECF family RNA polymerase sigma factor SC4B10.13c%2C probable ECF-family RNA polymerase sigma factor%2C len: 298 aa%3B similar to TR:Q9S1V5 (EMBL:AL109950) Streptomyces coelicolor sigma factor SCJ24.18c%2C 250 aa%3B fasta scores: opt: 1127 z-score: 1362.0 E(): 0%3B 72.8%25 identity in 243 aa overlap and to Streptomyces coelicolor SC4B10.06c%2C 301 aa%3B fasta scores: opt: 1112 z-score: 1158.1 E(): 0%3B 57.3%25 identity in 288 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene7175 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7112 SCO7113 SCO7113 SC4B10.14 SC4B10.14 7902488 7903123 + hypothetical protein SC4B10.14%2C possible integral membrane protein%2C len: 211 aa%3B similar to TR:Q9RCU9 (EMBL:AL136149) Streptomyces coelicolor integral membrane protein SCM2.15c%2C 219 aa%3B fasta scores: opt: 239 z-score: 284.5 E(): 2.2e-08%3B 34.5%25 identity in 220 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7176 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7113 SCO7114 SCO7114 SC4B10.15c SC4B10.15c 7903130 7904521 - hypothetical protein SC4B10.15c%2C conserved hypothetical protein%2C len: 463 aa%3B similar to TR:Q9ZN74 (EMBL:AB022095) Streptomyces griseus ORF3 protein%2C 456 aa%3B fasta scores: opt: 828 z-score: 929.7 E(): 0%3B 38.5%25 identity in 470 aa overlap gene gene7177 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7114 SCO7115 SCO7115 SC4B10.16c SC4B10.16c 7904521 7905621 - hypothetical protein SC4B10.16c%2C conserved hypothetical protein%2C len: 366 aa%3B similar to TR:Q9ZN75 (EMBL:AB022095) Streptomyces griseus ORF2 protein%2C 352 aa%3B fasta scores: opt: 941 z-score: 1090.4 E(): 0%3B 44.1%25 identity in 356 aa overlap. Contains match to Prosite entry PS00455 AMP-binding domain signature gene gene7178 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7115 SCO7116 SCO7116 SC4B10.17c SC4B10.17c 7905713 7906456 - hypothetical protein SC4B10.17c%2C conserved hypothetical protein%2C len: 247 aa%3B highly similar to TR:Q9RD73 (EMBL:AL136502) Streptomyces coelicolor hypothetical 27.0 kD protein SCF43.15c%2C 247 aa%3B fasta scores: opt: 1219 z-score: 1467.5 E(): 0%3B 71.6%25 identity in 250 aa overlap gene gene7179 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7116 SCO7117 SCO7117 SC4B10.18c SC4B10.18c 7906453 7907715 - ferredoxin reductase SC4B10.18c%2C probable ferredoxin reductase%2C len: 420 aa%3B similar to TR:BAA94714 (EMBL:AB031319) Nocardioides sp. ferredoxin reductase PhdD%2C 414 aa%3B fasta scores: opt: 928 z-score: 1051.4 E(): 0%3B 40.0%25 identity in 420 aa overlap%2C to SW:THCD_RHOER (EMBL:U17130) Rhodococcus erythropolis rhodocoxin reductase (EC 1.18.1.-) ThcD%2C 426aa%3B fasta scores: opt: 853 z-score: 966.6 E(): 0%3B 39.5%25 identity in 370 aa overlap and to TR:CAB69757 (EMBL:AL137187) Streptomyces coelicolor reductase SC7A8.08c%2C 421 aa%3B fasta scores: opt: 830 z-score: 732.2 E(): 0%3B 50.8%25 identity in 415 aa overlap. Contains Pfam match to entry PF00070 pyr_redox%2C Pyridine nucleotide-disulphide oxidoreductase gene gene7180 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7117 SCO7118 SCO7118 SC4B10.19c SC4B10.19c 7907864 7908628 - hypothetical protein SC4B10.19c%2C unknown%2C len: 254 aa gene gene7181 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7118 SCO7119 SCO7119 SC4B10.20 SC4B10.20 7908808 7909746 + dehydrogenase SC4B10.20%2C probable dehydrogenase%2C len: 312 aa%3B similar to SW:SERA_METJA (EMBL:U67544) Methanococcus jannaschii D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA%2C 524 aa%3B fasta scores: opt: 407 z-score: 451.9 E(): 1e-17%3B 31.6%25 identity in 266 aa overlap and to TR:CAB37585 (EMBL:AL035569) Streptomyces coelicolor oxidoreductase SC8D9.21c%2C 313 aa%3B fasta scores: opt: 1071 z-score: 988.6 E(): 0%3B 56.0%25 identity in 307 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH%2C D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3 gene gene7182 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7119 SCO7120 SCO7120 qrcB2 qrcB2 7910084 7911703 + ubiquinol-cytochrome C reductase cytochrome B subunit SC4B10.21%2C qcrB2%2C ubiquinol-cytochrome C reductase cytochrome B subunit%2C len: 539 aa%3B similar to SW:QCRB_STRCO (EMBL:AL049497) Streptomyces coelicolor ubiquinol-cytochrome C reductase cytochrome B subunit QcrB or SC6G10.21c%2C 545 aa%3B fasta scores: opt: 2311 z-score: 2220.7 E(): 0%3B 59.4%25 identity in 537 aa overlap and to SW:QCRB_STRLI (EMBL:AF107888) Streptomyces lividans ubiquinol-cytochrome C reductase cytochrome B subunit QcrB%2C 549 aa%3B fasta scores: opt: 2148 z-score: 2064.6 E(): 0%3B 56.3%25 identity in 542 aa overlap. Contains Pfam match to entry PF00033 cytochrome_b_N%2C Cytochrome b(N-terminal)/b6/petB. Also contains possible hydrophobic membrane spanning regions gene gene7183 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7120 SCO7121 SCO7121 SC4B10.22 SC4B10.22 7911841 7912686 + hypothetical protein SC4B10.22%2C possible hypothetical protein%2C len: 281 aa%3B similar to TR:Q9S1Z1 (EMBL:AL109747) Streptomyces coelicolor hypothetical 24.6 kDa protein SCJ21.16%2C 239 aa%3B fasta scores: opt: 989 z-score: 1075.6 E(): 0%3B 64.4%25 identity in 233 aa overlap and to Streptomyces coelicolor SC4B10.33%2C 239 aa%3B fasta scores: opt: 1034 z-score: 972.0 E(): 0%3B 67.0%25 identity in 233 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7184 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7121 SCO7122 SCO7122 SC4B10.23 SC4B10.23 7912792 7913283 + acetyltransferase SC4B10.23%2C possible acetyltransferase%2C len: 163 aa%3B similar to TR:Q9RCV6 (EMBL:AL136149) Streptomyces coelicolor acetyltransferase SCM2.08c%2C 168 aa%3B fasta scores: opt: 111 z-score: 148.3 E(): 0.86%3B 30.5%25 identity in 118 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene7185 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7122 SCO7123 SCO7123 SC4B10.24c SC4B10.24c 7913374 7914627 - acyltransferase SC4B10.24c%2C probable acyltransferase%2C len: 417 aa%3B similar to SW:ODO2_ALCEU (EMBL:X91877) Alcaligenes eutrophus dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB%2C 416 aa%3B fasta scores: opt: 793 z-score: 570.6 E(): 2.6e-24%3B 39.0%25 identity in 421 aa overlap%2C to C-terminal region of TR:Q9Z6I4 (EMBL:AF047034) Streptomyces seoulensis dihydrolipoamide acetyltransferase PdhB%2C 612 aa%3B fasta scores: opt: 1251 z-score: 887.0 E(): 0%3B 61.0%25 identity in 474 aa overlap and to TR:CAB51265 (EMBL:AL096872) Streptomyces coelicolor dihydrolipoamide succinyltransferase sucB SC5F7.20%2C 590 aa%3B fasta scores: opt: 1247 z-score: 694.4 E(): 4.7e-33%3B 63.5%25 identity in 457 aa overlap. Contains Pfam matches to entries PF00364 biotin_lipoyl%2C Biotin-requiring enzymes and PF00198 2-oxoacid_dh%2C 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and match to Prosite entry PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. Also contains region with high content in alanine%2C proline and threonine amino acid residues gene gene7186 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7123 SCO7124 SCO7124 aceE aceE 7914737 7917424 - pyruvate dehydrogenase subunit E1 E1 component%3B part of pyruvate dehydrogenase%3B forms a complex with DlaT and LpdC gene gene7187 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7124 SCO7125 SCO7125 SC4B10.26c SC4B10.26c 7917541 7918281 - hypothetical protein SC4B10.26c%2C conserved hypothetical protein%2C len: 246 aa%3B highly similar to TR:Q9S1U9 (EMBL:AL109950) Streptomyces coelicolor hypothetical 25.2 kDa protein SCJ4.24c%2C 242 aa%3B fasta scores: opt: 643 z-score: 729.3 E(): 0%3B 45.1%25 identity in 244 aa overlap and to Streptomyces coelicolor SC4B10.09c%2C 248 aa%3B fasta scores: opt: 779 z-score: 733.5 E(): 0%3B 51.6%25 identity in 244 aa overlap gene gene7188 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7125 SCO7126 SCO7126 SC4B10.27 SC4B10.27 7918561 7919013 + hypothetical protein SC4B10.27%2C unknown%2C len: 150 aa gene gene7189 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7126 SCO7127 SCO7127 SC4B10.28c SC4B10.28c 7919133 7919627 - hypothetical protein SC4B10.28c%2C hypothetical protein%2C len: 164 aa%3B similar to TR:Q9Z582 (EMBL:AL035569) Streptomyces coelicolor hypothetical protein SC8D9%2C 164 aa%3B fasta scores: opt:257 z-score: 326.3 E(): 1e-10%3B 34.1%25 identity in 132 aa overlap gene gene7190 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7127 SCO7128 SCO7128 SC4B10.29c SC4B10.29c 7919673 7921208 - transmembrane efflux protein SC4B10.29c%2C possible transmembrane efflux protein%2C len: 511 aa%3B similar to SW:AC22_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhodin transporter actII-2%2C 578 aa%3B fasta scores: opt: 730 z-score: 787.0 E(): 0%3B 34.9%25 identity in 484 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and possible hydrophobic membrane spanning regions gene gene7191 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7128 SCO7129 SCO7129 SC4B10.30c SC4B10.30c 7921324 7921794 - hypothetical protein SC4B10.30c%2C conserved hypothetical protein%2C len: 156 aa%3B similar to TR:CAB88826 (EMBL:AL353832) Streptomyces coelicolor hypothetical 16.8 kD protein SCE6.22c%2C 157 aa%3B fasta scores: opt: 788 z-score: 985.4 E(): 0%3B 75.2%25 identity in 157 aa overlap gene gene7192 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7129 SCO7130 SCO7130 SC4B10.31 SC4B10.31 7922097 7922885 + hypothetical protein SC4B10.31%2C hypothetical protein%2C len: 262 aa%3B similar to TR:O53404 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 28.9 kDa protein MTV017.09%2C 254 aa%3B fasta scores: opt: 820 z-score: 1018.9 E(): 0%3B 49.0%25 identity in 249 aa overlap gene gene7193 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7130 SCO7131 SCO7131 SC4B10.32 SC4B10.32 7922986 7923936 + lipase SC4B10.32%2C possible lipase%2C len: 316 aa%3B similar to TR:O52270 (EMBL:AF034088) Pseudomonas sp. lipase (EC 3.1.1.-) LipP%2C 308 aa%3B fasta scores: opt: 675 z-score: 762.7 E(): 0%3B 38.0%25 identity in 303 aa overlap gene gene7194 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7131 SCO7132 SCO7132 SC4B10.33 SC4B10.33 7923955 7924674 + hypothetical protein SC4B10.33%2C conserved hypothetical protein%2C len: 239 aa%3B highly similar to TR:Q9S1Z1 (EMBL:AL109747) Streptomyces coelicolor hypothetical 24.6 kDa protein SCJ21.16%2C 239 aa%3B fasta scores: opt: 1227 z-score: 1384.6 E(): 0%3B 79.0%25 identity in 238 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and match to Prosite entry PS00120 Lipases%2C serine active site gene gene7195 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7132 SCO7133 SCO7133 SC4B10.34 SC4B10.34 7924780 7925121 + hypothetical protein SC4B10.34%2C possible membrane protein%2C len: 113 aa%3B similar to TR:CAB89768 (EMBL:AL354616) Streptomyces coelicolor membrane protein SC3A4.22%2C 114 aa%3B fasta scores: opt: 276 z-score: 371.5 E(): 3.1e-13%3B 39.4%25 identity in 109 aa overlap. Contains possible hydrophobic membrane spanning region gene gene7196 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7133 SCO7134 SCO7134 SC4B10.35 SC4B10.35 7925356 7928127 + transcriptional regulator SC4B10.35%2C probable transcriptional regulatory protein%2C len: 923 aa%3B similar to TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13%2C 919 aa%3B fasta scores: opt: 2675 z-score: 2853.2 E(): 0%3B 50.6%25 identity in 926 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible helix-turn-helix motif at residues 876..897 (+3.18 SD) gene gene7197 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7134 SCO7135 SCO7135 SC4B10.36c SC4B10.36c 7928148 7928555 - hypothetical protein SC4B10.36c%2C unknown%2C len: 135 aa gene gene7198 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7135 SCO7136 SCO7136 SC4B10.37 SC4B10.37 7928742 7929485 + hypothetical protein SC4B10.37%2C conserved hypothetical protein%2C len: 247 aa%3B similar to TR:CAB76867 (EMBL:AL159139) Streptomyces coelicolor hypothetical 27.0 kD protein SCL6.02 %2C 255 aa%3B fasta scores: opt: 504 z-score: 571.2 E(): 2.4e-24%3B 41.3%25 identity in 247 aa overlap gene gene7199 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7136 SCO7137 SCO7137 SC4B10.38c SC4B10.38c 7929510 7932284 - regulatory protein SC8B1.01c%2C possible regulatory protein (fragment)%2C len: >708 aa%3B similar to TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13%2C 919 aa%3B fasta scores: opt: 2764 z-score: 2921.5 E(): 0%3B 63.0%25 identity in 690 aa overlap and to TR:Q9ZIW5 (EMBL:AF009336) Streptomyces coelicolor transcriptional activator of lipA gene%2C LipR%2C 941 aa%3B fasta scores: opt: 332 z-score: 350.0 E(): 5e-12%3B 29.5%25 identity in 698 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains a TTA leucine codon%2C possible target for bldA regulation~SC4B10.38c%2C probable transcriptional regulator (fragment)%2C len: >249 aa%3B similar to C-terminal region of TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13%2C 919 aa%3B fasta scores: opt: 1004 z-score: 1188.9 E(): 0%3B 64.3%25 identity in 249 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and possible helix-turn-helix motif at residues 210..231 (+3.95 SD) gene gene7200 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7137 SCO7138 SCO7138 SC8B1.02 SC8B1.02 7932458 7932790 + hypothetical protein SC8B1.02%2C conserved hypothetical protein%2C len: 110 aa%3B similar to TR:Q9S1Z3 (EMBL:AL109747) Streptomyces coelicolor hypothetical 13.6 kD protein SCJ21.14%2C 126 aa%3B fasta scores: opt: 264 z-score: 348.4 E(): 6.1e-12%3B 46.2%25 identity in 93 aa overlap gene gene7201 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7138 SCO7139 SCO7139 SC8B1.03 SC8B1.03 7932929 7934395 + aldehyde dehydrogenase SC8B1.03%2C probable aldehyde dehydrogenase (fragment)%2C len: >469 aa%3B similar to SW:DHAB_RHIME (EMBL:U39940) Rhizobium meliloti betaine aldehyde dehydrogenase (EC 1.2.1.8) BetB%2C 487 aa%3B fasta scores: opt: 1021 z-score: 1101.5 E(): 0%3B 40.5%25 identity in 462 aa overlap and to TR:CAB46804 (EMBL:AL096811) Streptomyces coelicolor aldehyde dehydrogenase SCI30A.27c%2C 462 aa%3B fasta scores: opt: 1074 z-score: 994.9 E(): 0%3B 52.9%25 identity in 448 aa overlap. Contains Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family%2C and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00687 Aldehyde dehydrogenases glutamic acid active site~SC9A4.01c%2C possible dehydrogenase (fragment)%2C len: >51 aa%3B highly similar to C-terminal region of SW:DHAB_BACSU (EMBL:U47861) Bacillus subtilis betaine aldehyde dehydrogenase (EC 1.2.1.8) gbsA%2C 490 aa%3B fasta scores: opt: 179 z-score: 258.5 E(): 6.3e-07%3B 56.0%25 identity in 50 aa overlap gene gene7202 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7139 SCO7140 SCO7140 SC9A4.02 SC9A4.02 7934492 7935322 + DNA-binding protein SC9A4.02%2C probable DNA-binding protein%2C len: 276 aa%3B highly similar to TR:Q9S1Q8 (EMBL:AL109972) Streptomyces coelicolor DNA-binding protein SCJ9A.12c%2C 279 aa%3B fasta scores: opt: 1046 z-score: 1203.5 E(): 0%3B 59.1%25 identity in 274 aa overlap. Contains a possible helix-turn-helix motif at residues 36..57 (+3.89 SD) gene gene7203 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7140 SCO7141 SCO7141 SC9A4.03c SC9A4.03c 7935350 7935958 - hypothetical protein SC9A4.03%2C possible nitroreductase%2C len: 202 aa%3B similar to SW:NFNB_ECOLI (EMBL:D25414) Escherichia coli oxygen-insensitive NAD(P)H nitroreductase (dihydropteridine reductase) (EC 1.6.99.7) NfnB%2C 217 aa%3B fasta scores: opt: 136 z-score: 170.8 E(): 0.048%3B 28.4%25 identity in 169 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase%2C Nitroreductase family gene gene7204 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7141 SCO7142 SCO7142 SC9A4.04 SC9A4.04 7936071 7936472 + hypothetical protein SC9A4.04%2C hypothetical protein%2C len: 133 aa%3B similar to SW:YODB_BACSU (EMBL:AF006665) Bacillus subtilis hypothetical 12.8 kDa protein in OdhA-CtpA intergenic region YodB%2C 112 aa%3B fasta scores: opt: 258 z-score: 328.5 E(): 7.9e-11%3B 44.0%25 identity in 91 aa overlap. Contains Pfam match to entry PF01638 DUF24%2C Protein of unknown function DUF24 gene gene7205 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7142 SCO7143 SCO7143 SC9A4.05 SC9A4.05 7936673 7939486 + transcriptional regulator SC9A4.05%2C probable transcriptional regulator%2C len: 937 aa%3B similar to TR:CAB89765 (EMBL:AL354616) Streptomyces coelicolor transcriptional regulator SC3A4.19%2C 932 aa%3B fasta scores: opt: 2131 z-score: 2221.3 E(): 0%3B 43.6%25 identity in 928 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). Also contains helix-turn-helix motif at residues 881..902 (+3.88 SD) gene gene7206 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7143 SCO7144 SCO7144 SC9A4.06 SC9A4.06 7939618 7940355 + ECF sigma factor SC9A4.06%2C possible ECF sigma factor%2C len: 245 aa%3B similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor sigma factor SCC57A.13c%2C 315 aa%3B fasta scores: opt: 395 z-score: 475.1 E(): 5.3e-19%3B 35.0%25 identity in 197 aa overlap and to SW:RPSH_PSEAE (EMBL:L14760) Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU%2C 193 aa%3B fasta scores: opt: 143 z-score: 180.2 E(): 0.014%3B 26.0%25 identity in 177 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily) gene gene7207 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7144 SCO7145 SCO7145 SC9A4.07 SC9A4.07 7940566 7941048 + transcriptional regulator SC9A4.07%2C possible transcriptional regulator%2C len: 160 aa%3B similar to TR:Q9X8V0 (EMBL:AL049826) Streptomyces coelicolor transcriptional regulator SCH24.36c%2C 154 aa%3B fasta scores: opt: 218 z-score: 278.5 E(): 4.8e-08%3B 36.5%25 identity in 115 aa overlap and to SW:MPRA_ECOLI (EMBL:X54151) Escherichia coli transcriptional repressor MprA%2C 176 aa%3B fasta scores: opt: 139 z-score: 182.0 E(): 0.011%3B 25.6%25 identity in 125 aa overlap. Contains Pfam match to entry PF00325 crp%2C Bacterial regulatory proteins%2C crp family and possible helix-turn-helix motif at residues 57..78 (+3.58 SD) gene gene7208 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7145 SCO7146 SCO7146 SC9A4.08 SC9A4.08 7941058 7941408 + regulatory protein SC9A4.08%2C possible regulatory protein%2C len: 116 aa%3B similar to TR:Q9X8Y1 (EMBL:AL078610) Streptomyces coelicolor transcriptional regulator SCH35.25%2C 102 aa%3B fasta scores: opt: 144 z-score: 203.2 E(): 0.00075%3B 37.9%25 identity in 87 aa overlap. Contains Pfam match to entry PF01022 HTH_5%2C Bacterial regulatory protein%2C arsR family gene gene7209 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7146 SCO7147 SCO7147 SC9A4.09 SC9A4.09 7941649 7942416 + ketoreductase SC9A4.09%2C probable ketoreductase%2C len: 255 aa%3B similar to TR:Q9RN66 (EMBL:AF187532) Streptomyces nogalater C-7 ketoreductase%2C 281 aa%3B fasta scores: opt: 616 z-score: 709.0 E(): 5e-32%3B 40.3%25 identity in 243 aa overlap and to SW:FABG_THEMA (EMBL:AE001811) Thermotoga maritima 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) FabG%2C 246 aa%3B fasta scores: opt: 448 z-score: 519.1 E(): 1.9e-21%3B 34.1%25 identity in 246 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature gene gene7210 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7147 SCO7148 SCO7148 SC9A4.10 SC9A4.10 7942508 7942861 + hypothetical protein SC9A4.10%2C hypothetical protein%2C len: 117 aa%3B similar to C-terminal region of SW:DAC_STRSQ (EMBL:M26842) Streptomyces sp. D-alanyl-D-alanine carboxypeptidase precursor (EC 3.4.16.4) Dac%2C 406 aa%3B fasta scores: opt: 186 z-score: 224.1 E(): 5.1e-05%3B 43.1%25 identity in 102 aa overlap gene gene7211 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7148 SCO7149 SCO7149 SC9A4.11 SC9A4.11 7942893 7943348 + lyase SC9A4.11%2C possible lyase%2C len: 151 aa%3B similar to TR:Q9XA78 (EMBL:AL096837) Streptomyces coelicolor lyase SCF43A.37c%2C 152 aa%3B fasta scores: opt: 679 z-score: 811.2 E(): 0%3B 69.7%25 identity in 145 aa overlap and to SW:BHC3_RHOGO (EMBL:X75635) Rhodococcus globerulus biphenyl-2%2C3-diol 1%2C2-dioxygenase III (EC 1.13.11.39) BphC3%2C 189 aa%3B fasta scores: opt: 146 z-score: 184.1 E(): 0.0087%3B 29.3%25 identity in 123 aa overlap gene gene7212 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7149 SCO7150 SCO7150 SC9A4.12c SC9A4.12c 7943578 7944414 - acetyltransferase SC9A4.12c%2C possible acetyltransferase%2C len: 278 aa%3B similar to TR:Q9V2R3 (EMBL:AJ248283) Pyrococcus abyssi hypothetical 30.2 kDa protein PAB2346%2C 266 aa%3B fasta scores: opt: 149 z-score: 182.6 E(): 0.011%3B 33.3%25 identity in 90 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene7213 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7150 SCO7151 SCO7151 SC9A4.13 SC9A4.13 7944613 7945416 + hypothetical protein SC9A4.13%2C conserved hypothetical protein%2C len: 267 aa%3B similar to TR:Q9S1U9 (EMBL:AL109950) Streptomyces coelicolor hypothetical 25.2 kDa protein%2C 242 aa%3B fasta scores: opt: 358 z-score: 430.9 E(): 1.6e-16%3B 32.6%25 identity in 258 aa overlap gene gene7214 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7151 SCO7152 SCO7152 SC9A4.14 SC9A4.14 7945453 7946277 + hypothetical protein SC9A4.14%2C unknown%2C len: 274 aa. High content in alanine%2C arginine%2C glutamate and leucine amino acid residues gene gene7215 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7152 SCO7153 SCO7153 SC9A4.15 SC9A4.15 7946421 7947839 + sugar transporter SC9A4.15%2C probable sugar transporter%2C len: 472 aa%3B identical to TR:Q9ZBQ1 (EMBL:AL034447) Streptomyces coelicolor sugar transporter SC7A1.22%2C 473 aa and highly similar to SW:GLCP_SYNY3 (EMBL:X15988) Synechocystis sp. glucose transport protein GlcP%2C 468 aa%3B fasta scores: opt: 1477 z-score: 1671.3 E(): 0%3B 50.6%25 identity in 468 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and matches to Prosite entries PS00012 Phosphopantetheine attachment site%2C PS00217 Sugar transport proteins signature 2 and PS00216 Sugar transport proteins signature 1. Also contains possible hydrophobic membrane spanning regions gene gene7216 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7153 SCO7154 SCO7154 ilvC2 ilvC2 7947903 7948901 - ketol-acid reductoisomerase catalyzes the formation of (R)-2%2C3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis gene gene7217 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7154 SCO7155 SCO7155 SC9A4.17 SC9A4.17 7949234 7950301 + hypothetical protein SC9A4.17%2C unknown%2C len: 355 aa gene gene7218 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7155 SCO7156 SCO7156 SC9A4.18c SC9A4.18c 7950408 7950953 - hypothetical protein SC9A4.18c%2C conserved hypothetical protein%2C len: 152 aa%3B similar to TR:Q9RRW9 (EMBL:AE002067) Deinococcus radiodurans conserved hypothetical protein DR2363%2C 160 aa%3B fasta scores: opt: 161 z-score: 210.3 E(): 0.0003%3B 34.0%25 identity in 147 aa overlap gene gene7219 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7156 SCO7157 SCO7157 SC9A4.19c SC9A4.19c 7950950 7951531 - hypothetical protein SC9A4.19c%2C possible integral membrane protein%2C len: aa%3B similar to TR:Q9S277 (EMBL:AL096844) Streptomyces coelicolor integral membrane protein SCI28.06c%2C 421 aa%3B fasta scores: opt: 1032 z-score: 1103.0 E(): 0%3B 77.2%25 identity in 189 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7220 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7157 SCO7158 SCO7158 SC9A4.20 SC9A4.20 7951544 7953982 + hypothetical protein SC9A4.20%2C conserved hypothetical protein%2C len: 812 aa%3B similar to TR:Q9RJC6 (EMBL:AL133171) Streptomyces coelicolor hypothetical 89.7 kDa protein SCF81.26%2C 835 aa%3B fasta scores: opt: 1262 z-score: 1348.6 E(): 0%3B 37.3%25 identity in 808 aa overlap. Contains 2x Pfam matches to entry PF00989 PAS%2C PAS domain%2C Pfam match to PF00785 PAC%2C PAC motif and match to Prosite entry PS00213 Lipocalin signature gene gene7221 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7158 SCO7159 SCO7159 SC9A4.21 SC9A4.21 7954049 7955986 + hypothetical protein SC9A4.21%2C possible integral membrane protein%2C len: 645 aa%3B similar to TR:O32225 (EMBL:Z99121) Bacillus subtilis YvaC protein%2C 631 aa%3B fasta scores: opt: 402 z-score: 435.7 E(): 8.4e-17%3B 23.8%25 identity in 627 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7222 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7159 SCO7160 SCO7160 SC9A4.22c SC9A4.22c 7956000 7956833 - hypothetical protein SC9A4.22c%2C conserved hypothetical protein%2C len: 277 aa%3B similar to TR:Q9RJW0 (EMBL:AL117387) Streptomyces coelicolor hypothetical 31.6 kDa protein SCF41.09%2C 294 aa%3B fasta scores: opt: 504 z-score: 582.4 E(): 5.7e-25%3B 38.1%25 identity in 281 aa overlap gene gene7223 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7160 SCO7161 SCO7161 SC9A4.23c SC9A4.23c 7956843 7957625 - 3-oxoacyl-ACP reductase SC9A4.23c%2C probable 3-oxoacyl-[acyl-carrier protein] reductase%2C len: 260 aa%3B similar to SW:FABG_ECOLI (EMBL:M84991) Escherichia coli 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) FabG%2C 244 aa%3B fasta scores: opt: 453 z-score: 474.7 E(): 5.6e-19%3B 34.4%25 identity in 247 aa overlap and to TR:Q9RJV4 (EMBL:AL117387) Streptomyces coelicolor probable oxidoreductase SCF41.15%2C 263 aa%3B fasta scores: opt: 1092 z-score: 881.9 E(): 0%3B 72.5%25 identity in 251 aa overlap. Contains Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature. Contains possible hydrophobic membrane spanning region gene gene7224 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7161 SCO7162 SCO7162 SC9A4.24c SC9A4.24c 7957724 7958647 - oxidoreductase SC9A4.24c%2C possible oxidoreductase%2C len: 307 aa%3B similar to TR:Q9RJW1 (EMBL:AL117387) Streptomyces coelicolor possible oxidoreductase SCF41.08%2C 334 aa%3B fasta scores: opt: 705 z-score: 808.0 E(): 0%3B 48.1%25 identity in 314 aa overlap gene gene7225 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7162 SCO7163 SCO7163 SC9A4.25c SC9A4.25c 7958644 7959456 - transferase SC9A4.25c%2C possible transferase%2C len: 270 aa%3B similar to TR:CAB87566 (EMBL:AJ277295) Sphingomonas sp. acyl transferase FldZ protein%2C 224 aa%3B fasta scores: opt: 286 z-score: 338.7 E(): 2.1e-11%3B 27.4%25 identity in 223 aa overlap gene gene7226 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7163 SCO7164 SCO7164 SC9A4.26c SC9A4.26c 7959459 7961477 - hypothetical protein SC9A4.26c%2C unknown%2C len: 672 aa gene gene7227 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7164 SCO7165 SCO7165 SC9A4.27c SC9A4.27c 7961479 7962390 - sugar-binding integral membrane transport protein SC9A4.27c%2C probable sugar-binding integral membrane transport protein%2C len: 319 aa%3B similar to TR:Q9RJV6 (EMBL:AL117387) Streptomyces coelicolor binding-protein-dependent transport protein SCF41.13%2C 280 aa%3B fasta scores: opt: 1039 z-score: 1201.7 E(): 0%3B 57.2%25 identity in 264 aa overlap and to SW:MSMG_STRMU (EMBL:M77351) Streptococcus mutans multiple sugar-binding transport system permease MsmG%2C 277 aa%3B fasta scores: opt: 512 z-score: 596.7 E(): 9.1e-26%3B 32.4%25 identity in 275 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene7228 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7165 SCO7166 SCO7166 SC9A4.28c SC9A4.28c 7962441 7963373 - sugar-transporter integral membrane protein SC9A4.28c%2C probable sugar-transporter integral membrane protein%2C len: 310 aa%3B similar to TR:Q9RJV7 (EMBL:AL117387) Streptomyces coelicolor binding protein dependent transport protein SCF41.12%2C 303 aa%3B fasta scores: opt: 913 z-score: 1073.6 E(): 0%3B 46.9%25 identity in 309 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene7229 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7166 SCO7167 SCO7167 SC9A4.29c SC9A4.29c 7963370 7964647 - sugar-binding protein SC9A4.29c%2C probable sugar-binding protein%2C len: 425 aa%3B similar to TR:Q9RJV8 (EMBL:AL117387) Streptomyces coelicolor solute-binding protein SCF41.11%2C 422 aa%3B fasta scores: opt: 946 z-score: 1081.0 E(): 0%3B 40.1%25 identity in 419 aa overlap and to SW:MSME_STRMU (EMBL:M77351) Streptococcus mutans multiple sugar-binding protein precursor MsmE%2C 420 aa%3B fasta scores: opt: 233 z-score: 268.9 E(): 1.6e-07%3B 25.3%25 identity in 297 aa overlap. Contains 2x Pfam matches to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene7230 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7167 SCO7168 SCO7168 SC9A4.30 SC9A4.30 7964783 7965457 + GntR family transcriptional regulator SC9A4.30%2C probable gntR-family transcriptional regulator%2C len: 224 aa%3B similar to TR:Q9XA67 (EMBL:AL096822) Streptomyces coelicolor gntR-family transcriptional regulator SCGD3.11c%2C 216 aa%3B fasta scores: opt: 305 z-score: 351.3 E(): 4.2e-12%3B 32.7%25 identity in 196 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family. Also contains possible helix-turn-helix motif at residues 36..57 (+3.11 SD) gene gene7231 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7168 SCO7169 SCO7169 SC9A4.31c SC9A4.31c 7965442 7965876 - hypothetical protein SC9A4.31c%2C unknown%2C len: 144 aa. Highly hydrophilic. Contains 2x conserved repeat AGSGNT and high content in G+C (78.24%25) gene gene7232 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7169 SCO7170 SCO7170 SC9A4.32 SC9A4.32 7966015 7968375 + sugar hydrolase SC9A4.32%2C possible sugar hydrolase%2C len: 786 aa%3B C-terminal region similar to TR:O88021 (EMBL:AL031107) Streptomyces coelicolor glucosidase SC5A7.15c%2C 466 aa%3B fasta scores: opt: 270 z-score: 286.2 E(): 1.8e-08%3B 27.2%25 identity in 427 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7233 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7170 SCO7171 SCO7171 SC9A4.33c SC9A4.33c 7968419 7968850 - lyase SC9A4.33c%2C possible lyase%2C len: 143 aa%3B similar to TR:O86701 (EMBL:AL031515) Streptomyces coelicolor lyase SC5C7.04%2C 138 aa%3B fasta scores: opt: 119 z-score: 158.2 E(): 0.24%3B 30.6%25 identity in 134 aa overlap gene gene7234 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7171 SCO7172 SCO7172 SC9A4.34 SC9A4.34 7969170 7969406 + hypothetical protein SC9A4.34%2C possible membrane protein%2C len: 78 aa. Contains possible hydrophobic membrane spanning regions gene gene7235 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7172 SCO7173 SCO7173 SC8A11.01 SC8A11.01 7969712 7972438 + transcriptional regulator SC8A11.01%2C possible transcriptional regulator (fragment)%2C len: >750 aa%3B similar to TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13%2C 919 aa%3B fasta scores: opt: 818 z-score: 913.7 E(): 0%3B 32.6%25 identity in 775 aa overlap. Contains Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains a possible helix-turn-helix motif at residues 699..720 (+3.25 SD)~SC9A4.35%2C possible regulatory protein (fragment)%2C len: >191 aa%3B similar to N-terminal region of TR:Q9S1Z4 (EMBL:AL109747) Streptomyces coelicolor probable transcriptional regulator SCJ21.13%2C 919 aa%3B fasta scores: opt: 470 z-score: 538.6 E(): 1.6e-22%3B 44.4%25 identity in 187 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene7236 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7173 SCO7174 SCO7174 SC8A11.02c SC8A11.02c 7972368 7972637 - hypothetical protein SC8A11.02c%2C unknown%2C len: 89 aa gene gene7237 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7174 SCO7175 SCO7175 SC8A11.03 SC8A11.03 7972971 7973441 + regulator SC8A11.03%2C possible regulator%2C len: 156 aa%3B similar to TR:Q9S2F7 (EMBL:AL096852) Streptomyces coelicolor regulator SCE19A.24%2C 142 aa%3B fasta scores: opt: 272 z-score: 353.0 E(): 3.4e-12%3B 36.9%25 identity in 130 aa overlap gene gene7238 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7175 SCO7176 SCO7176 SC8A11.04c SC8A11.04c 7973481 7977242 - peptidase SC8A11.04c%2C probable peptidase%2C len: 1253 aa%3B similar to TR:Q9RL54 (EMBL:AL121596) Streptomyces coelicolor probable peptidase SCF51A.10%2C 1245 aa%3B fasta scores: opt: 1827 z-score: 1848.3 E(): 0%3B 37.2%25 identity in 1300 aa overlap%2C to TR:P95684 (EMBL:D83672) Streptomyces albogriseolus subtilisin-like protease%2C 1102 aa%3B fasta scores: opt: 1365 z-score: 1380.6 E(): 0%3B 33.4%25 identity in 1268 aa overlap and to Streptomyces coelicolor probable peptidase SC8A11.16c%2C 1239 aa%3B fasta scores: opt: 1835 z-score: 1467.4 E(): 0%3B 46.9%25 identity in 1279 aa overlap. Contains Pfam matches to entries PF00082 Peptidase_S8%2C Subtilase family and PF02225 PA%2C PA domain and matches to Prosite entries PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site%2C PS00137 Serine proteases%2C subtilase family%2C histidine active site and PS00138 Serine proteases%2C subtilase family%2C serine active site. Also contains possible N-terminal region signal peptide sequence gene gene7239 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7176 SCO7177 SCO7177 SC8A11.05 SC8A11.05 7977478 7978122 + hypothetical protein SC8A11.05%2C unknown%2C len: 214 aa gene gene7240 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7177 SCO7178 SCO7178 SC8A11.06 SC8A11.06 7978110 7978478 + transcriptional regulator SC8A11.06%2C probable transcriptional regulatory protein%2C len: 122 aa%3B similar to SW:BRPA_STRHY (EMBL:M64783) Streptomyces hygroscopicus bialaphos biosynthetic pathway regulatory protein BrpA%2C 256 aa%3B fasta scores: opt: 165 z-score: 209.2 E(): 0.00035%3B 34.4%25 identity in 122 aa overlap. Contains possible helix-turn-helix motif at residues 77..98 (+4.46 SD) gene gene7241 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7178 SCO7179 SCO7179 SC8A11.07c SC8A11.07c 7978957 7980885 - amidase SC8A11.07c%2C possible amidase%2C len: 642 aa%3B similar to TR:Q9S2M7 (EMBL:AL109661) Streptomyces coelicolor hypothetical 100.7 kDa protein SC6E10.10%2C 943 aa%3B fasta scores: opt: 1082 z-score: 1143.6 E(): 0%3B 40.2%25 identity in 684 aa overlap and to SW:CWHA_ACHLY Achromobacter lyticus N-acetylmuramoyl-L-alanine amidase A (EC 3.5.1.28) CwhA%2C 177 aa%3B fasta scores: opt: 214 z-score: 235.8 E(): 1.1e-05%3B 29.4%25 identity in 160 aa overlap. Contains Pfam match to entry PF01510 Amidase_2%2C N-acetylmuramoyl-L-alanine amidase. Also contains possible N-terminal region signal peptide sequence gene gene7242 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7179 SCO7180 SCO7180 SC8A11.08c SC8A11.08c 7981070 7981423 - hypothetical protein SC8A11.08c%2C hypothetical protein%2C len: 117 aa%3B similar to TR:AAF70105 (EMBL:AF257324) Streptomyces galilaeus polyketide oxygenase AknX%2C 122 aa%3B fasta scores: opt: 151 z-score: 213.3 E(): 0.00021%3B 34.3%25 identity in 105 aa overlap gene gene7243 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7180 SCO7181 SCO7181 SC8A11.09 SC8A11.09 7981617 7982402 + ABC transporter ATP-binding protein SC8A11.09%2C probable branched amino acid transport system ATP-binding protein%2C len: 261 aa%3B similar to SW:LIVG_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport ATP-binding protein LivG%2C 255 aa%3B fasta scores: opt: 586 z-score: 615.7 E(): 7.9e-27%3B 41.6%25 identity in 250 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene7244 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7181 SCO7182 SCO7182 SC8A11.10 SC8A11.10 7982399 7983112 + ABC transporter ATP-binding protein SC8A11.10%2C probable branched amino acid transport system ATP-binding protein%2C len: 237 aa%3B similar to SW:LIVF_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport ATP-binding protein LivF%2C 237 aa%3B fasta scores: opt: 687 z-score: 739.1 E(): 0%3B 50.7%25 identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene7245 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7182 SCO7183 SCO7183 SC8A11.11 SC8A11.11 7983160 7984032 + branched amino acid transport system permease SC8A11.11%2C probable branched amino acid transport system permease%2C len: 290 aa%3B similar to SW:LIVH_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport system permease LivH%2C 308 aa%3B fasta scores: opt: 427 z-score: 471.1 E(): 9e-19%3B 34.4%25 identity in 305 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7246 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7183 SCO7184 SCO7184 SC8A11.12 SC8A11.12 7984035 7985084 + branched amino acid transport system permease SC8A11.12%2C probable branched amino acid transport system permease%2C len: 349 aa%3B similar to SW:LIVM_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport system permease%2C LivM%2C 425 aa%3B fasta scores: opt: 254 z-score: 285.7 E(): 1.9e-08%3B 28.1%25 identity in 360 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7247 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7184 SCO7185 SCO7185 SC8A11.13 SC8A11.13 7985081 7986271 + branched amino acid binding hypothetical protein SC8A11.13%2C probable branched amino acid binding hypothetical protein%2C len: 396 aa%3B similar to SW:LIVK_ECOLI (EMBL:M29378) Escherichia coli leucine-specific binding protein precursor LivK%2C 369 aa%3B fasta scores: opt: 233 z-score: 262.9 E(): 3.6e-07%3B 24.7%25 identity in 360 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene7248 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7185 SCO7186 SCO7186 SC8A11.14 SC8A11.14 7986335 7986640 + hypothetical protein SC8A11.14%2C possible integral membrane protein%2C len: 101 aa. Contains possible hydrophobic membrane spanning regions gene gene7249 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7186 SCO7187 SCO7187 SC8A11.15c SC8A11.15c 7986672 7988690 - lipoprotein SC8A11.15c%2C possible lipoprotein%2C len: 672 aa%3B similar to TR:Q98LR9 (EMBL:AP002996) Rhizobium loti probable hypothetical protein MLL0907%2C 622 aa%3B fasta scores: opt: 1110 Z-score: 1188.9 E(): 1.4e-58%3B 33.122%25 identity in 631 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene7250 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7187 SCO7188 SCO7188 SC8A11.16c SC8A11.16c 7988871 7992590 - peptidase SC8A11.16c%2C possible peptidase%2C len: 1210 aa%3B similar to TR:CAB86111 (EMBL:AL163003) Streptomyces coelicolor peptidase SCC24.17c%2C 1220 aa%3B fasta scores: opt: 2418 z-score: 2421.7 E(): 0%3B 41.6%25 identity in 1257 aa overlap%2C to SW:SUBT_BACAM (EMBL:K02496) Bacillus amyloliquefaciens subtilisin BPM' precursor (EC 3.4.21.62) Apr%2C 382 aa%3B fasta scores: opt: 478 z-score: 483.8 E(): 1.8e-19%3B 41.4%25 identity in 290 aa overlap and to Streptomyces coelicolor possible peptidase SC8A11.04c%2C 1253 aa%3B fasta scores: opt: 1835 z-score: 1440.0 E(): 0%3B 46.9%25 identity in 1279 aa overlap. Contains Pfam matches to entries PF00082 Peptidase_S8%2C Subtilase family and PF02225 PA%2C PA domain and matches to Prosite entries PS00136 Serine proteases%2C subtilase family%2C aspartic acid active site%2C PS00137 Serine proteases%2C subtilase family%2C histidine active site and PS00138 Serine proteases%2C subtilase family%2C serine active site. Also contains possible N-terminal region signal peptide sequence gene gene7251 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7188 SCO7189 SCO7189 SC8A11.17c SC8A11.17c 7992891 7993154 - hypothetical protein SC8A11.17c%2C hypothetical protein%2C len: 87 aa%3B similar to SW:Y898_MYCTU (EMBL:Z73101) Mycobacterium tuberculosis hypothetical 9.9 kDa protein MTCY31.26c%2C 87 aa%3B fasta scores: opt: 256 z-score: 337.1 E(): 2.6e-11%3B 48.2%25 identity in 85 aa overlap. Highly hydrophilic gene gene7252 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7189 SCO7190 SCO7190 SC8A11.18 SC8A11.18 7993470 7994357 + hypothetical protein SC8A11.18%2C hypothetical protein%2C len: 295 aa%3B similar to TR:AAF67510 (EMBL:AF170880) Streptomyces sphaeroides NovQ%2C 271 aa%3B fasta scores: opt: 177 z-score: 217.8 E(): 0.00012%3B 24.7%25 identity in 194 aa overlap gene gene7253 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7190 SCO7191 SCO7191 SC8A11.19c SC8A11.19c 7994561 7995370 - hypothetical protein SC8A11.19c%2C possible hypothetical protein%2C len: 269 aa%3B similar to TR:Q9S1U9 (EMBL:AL109950) Streptomyces coelicolor hypothetical 25.2 kDa protein SCJ24.24c%2C 242 aa%3B fasta scores: opt: 745 z-score: 832.0 E(): 0%3B 48.8%25 identity in 244 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7254 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7191 SCO7192 SCO7192 SC8A11.20 SC8A11.20 7995629 7996294 + sigma factor SC8A11.20%2C possible sigma factor%2C len: 221 aa%3B similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor sigma factor SCC57A.13c%2C 315 aa%3B fasta scores: opt: 381 z-score: 442.9 E(): 3.4e-17%3B 39.9%25 identity in 178 aa overlap gene gene7255 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7192 SCO7193 SCO7193 SC8A11.21 SC8A11.21 7996511 7997461 + hypothetical protein SC8A11.21%2C conserved hypothetical protein%2C len: 316 aa%3B similar to TR:O07180 (EMBL:Z96797) Mycobacterium tuberculosis hypothetical 36.0 kDa protein MTCY07H7A.10%2C 355 aa%3B fasta scores: opt: 1256 z-score: 1437.6 E(): 0l%3B 60.9%25 identity in 307 aa overlap gene gene7256 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7193 SCO7194 SCO7194 SC8A11.22 SC8A11.22 7997836 7998651 + polysaccharide biosynthesis protein SC8A11.22%2C possible polysaccharide biosynthesis protein%2C len: 271 aa%3B similar to N-terminal region of SW:SPSK_BACSU (EMBL:X73124) Bacillus subtilis spore coat polysaccharide biosynthesis protein SpsK%2C 432 aa%3B fasta scores: opt: 278 z-score: 331.5 E(): 5.3e-11%3B 28.1%25 identity in 242 aa overlap gene gene7257 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7194 SCO7195 SCO7195 SC8A11.23c SC8A11.23c 7999105 7999371 - hypothetical protein SC8A11.23c%2C unknown%2C len: 88 aa gene gene7258 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7195 SCO7196 SCO7196 SC8A11.24c SC8A11.24c 7999751 8000617 - ion transport integral membrane protein SC8A11.24c%2C possible ion transport integral membrane protein%2C len: 288 aa%3B similar to SW:KCSA_STRLI (EMBL:Z37969) Streptomyces lividans voltage-gated potassium channel KcsA%2C 160 aa%3B fasta scores: opt: 302 z-score: 373.1 E(): 2.6e-13%3B 41.0%25 identity in 156 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7259 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7196 SCO7197 SCO7197 SC8A11.25c SC8A11.25c 8000799 8002337 - amino acid ABC transporter permease SC8A11.25c%2C probable amino acid transport integral membrane protein%2C len: 512 aa%3B similar to SW:ALST_BACSU (EMBL:Z73234) Bacillus subtilis amino acid carrier protein AlsT%2C 465 aa%3B fasta scores: opt: 560 z-score: 628.4 E(): 1.6e-27%3B 35.2%25 identity in 454 aa overlap. Contains Pfam match to entry PF01235 Na_Ala_symp%2C Sodium:alanine symporter family and possible hydrophobic membrane spanning regions gene gene7260 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7197 SCO7198 SCO7198 SC1D2.01c SC1D2.01c 8002667 8003086 - regulatory protein SC1D2.01c%2C possible regulatory protein%2C partial CDS%2C len: >106 aa. Similar to Streptomyces coelicolor TR:Q9XAJ6(EMBL:AL079348) regulator%2C SC66T3.17 (360 aa)%2C fasta scores opt: 257 z-score: 345.4 E(): 9.2e-12 51.0%25 identity in 96 aa overlap.~SC8A11.26%2C possible regulatory protein (fragment)%2C len: >73 aa%3B similar to N-terminal region of TR:Q9XAJ6 (EMBL:AL079348) Streptomyces coelicolor regulator SC66T3.17%2C 360 aa%3B fasta scores: opt: 162 z-score: 232.5 E(): 1.8e-05%3B 55.4%25 identity in 56 aa overlap gene gene7261 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7198 SCO7199 SCO7199 SC1D2.02c SC1D2.02c 8003169 8003564 - hypothetical protein SC1D2.02c%2C possible membrane protein%2C len: 131 aa. Similar to Streptomyces coelicolor TR:Q9XAF9(EMBL:AL079356) hypothetical 19.3 kd protein%2C SC6G9.23 (187 aa)%2C fasta scores opt: 224 z-score: 255.7 E(): 9.1e-07 41.1%25 identity in 141 aa overlap. Contains a possible membrane spanning hydrophobic domain. gene gene7262 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7199 SCO7200 SCO7200 SC1D2.03c SC1D2.03c 8003571 8004116 - hypothetical protein SC1D2.03c%2C unknown%2C len: 181 aa. Weakly similar to several proteins of unknown function e.g. Streptomyces coelicolor TR:CAB88434 (EMBL:AL353815) hypothetical 15.8 kd protein%2C SCD6.05C (139 aa)%2C fasta scores opt: 147 z-score: 192.6 E(): 0.003 34.2%25 identity in 120 aa overlap. gene gene7263 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7200 SCO7201 SCO7201 SC1D2.04 SC1D2.04 8004272 8004748 + transcriptional regulator SC1D2.04%2C possible transcriptional regulator%2C len: 158 aa. Similar to several e.g. Streptomyces coelicolor TR:Q9X8J3(EMBL:AL049841) transcriptional regulator%2C SCE9.21C (148 aa)%2C fasta scores opt: 200 z-score: 250.8 E(): 1.7e-06 32.1%25 identity in 134 aa overlap. Contains a Pfam match to entry PF01047 MarR%2C MarR family and has a helix-turn-helix motif situated between residues 50..71 (+2.73 SD). gene gene7264 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7201 SCO7202 SCO7202 SC1D2.05 SC1D2.05 8004831 8005571 + hypothetical protein SC2H12.01%2C possible membrane protein%2C partial CDS%2C len: >87 aa. Contains a possible membrane spanning hydrophobic domain.~SC1D2.05%2C possible membrane protein%2C partial CDS%2C len >191 aa. Contains possible membrane spanning hydrophobic domains. Overlaps and extends into CDS SC2H12.01 on the adjoining cosmid. gene gene7265 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7202 SCO7203 SCO7203 SC2H12.02 SC2H12.02 8005671 8006447 + hypothetical protein SC2H12.02%2C possible integral membrane protein%2C len: 258 aa. Contains multiple possible membrane spanning hydrophobic domains. gene gene7266 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7203 SCO7204 SCO7204 SC2H12.03c SC2H12.03c 8007146 8007340 - hypothetical protein SC2H12.03c%2C unknown%2C len: 64 aa. gene gene7267 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7204 SCO7205 SCO7205 SC2H12.04 SC2H12.04 8007497 8008357 + hydrolase SC2H12.04%2C possible hydrolase%2C len: 286 aa. Highly similar to many including: Moraxella sp. SW:DEH1_MORSP(EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa)%2C fasta scores opt: 556 z-score: 678.4 E(): 2.6e-30 35.6%25 identity in 292 aa overlap and Streptomyces coelicolor: TR:Q9RD12(EMBL:AL133422) hydrolase%2C SCM1.32 (298 aa)%2C fasta scores opt: 653 z-score: 795.7 E(): 0 42.2%25 identity in 287 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene7268 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7205 SCO7206 SCO7206 SC2H12.05 SC2H12.05 8008499 8009599 + hypothetical protein SC2H12.05%2C possible membrane protein%2C len: 366 aa. Contains possible membrane spanning hydrophobic domains. gene gene7269 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7206 SCO7207 SCO7207 SC2H12.06 SC2H12.06 8009646 8010506 + hypothetical protein SC2H12.06%2C possible membrane protein%2C len: 286 aa. Contains possible membrane spanning hydrophobic domains. gene gene7270 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7207 SCO7208 SCO7208 SC2H12.07c SC2H12.07c 8010429 8010662 - hypothetical protein SC2H12.07c%2C unknown%2C len: 77 aa. gene gene7271 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7208 SCO7209 SCO7209 SC2H12.08c SC2H12.08c 8010715 8010855 - hypothetical protein SC2H12.08c%2C doubtful CDS%2C len: 46 aa. gene gene7272 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7209 SCO7210 SCO7210 SC2H12.09 SC2H12.09 8010973 8011434 + hypothetical protein SC2H12.09%2C hypothetical protein%2C len: 153 aa. Highly similar to Streptomyces lincolnensis SW:YMEL_STRLN(EMBL:X95703) hypothetical 17.2 kd protein (150 aa)%2C fasta scores opt: 628 z-score: 750.6 E(): 0 56.4%25 identity in 149 aa overlap gene gene7273 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7210 SCO7211 SCO7211 SC2H12.10c SC2H12.10c 8011635 8013374 - glycosyl hydrolase SC2H12.10c%2C possible glycosyl hydrolase%2C len: 579 aa. Similar in regions to many glycosyl hydrolases including: Arthrobacter sp. SW:E13B_ARTSP(EMBL:D23668) glucan endo-1%2C3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa)%2C fasta scores opt: 449 z-score: 497.8 E(): 3e-20 27.8%25 identity in 533 aa overlap. Also similar to the C-terminus of Streptomyces coelicolor TR:O69947(EMBL:AL023862) hypothetical 133.5 kd protein%2C SC3F9.07 (1238 aa)%2C fasta scores opt: 1923 z-score: 2123.6 E(): 0 66.5%25 identity in 403 aa overlap. Note%2C the last 131 aa of this CDS are identical to those in the analogous position on the adjoining CDS%2C SC2H12.11c. Contains a possible N-terminal signal sequence. Contains a Pfam match to entry PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain%2C 3 copies. gene gene7274 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7211 SCO7212 SCO7212 SC2H12.11c SC2H12.11c 8013393 8016281 - glycosyl hydrolase SC2H12.11c%2C possible glycosyl hydrolase%2C len: 962 aa. Similar to many including: Arthrobacter sp. SW:E13B_ARTSP(EMBL:D23668) glucan endo-1%2C3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa)%2C fasta scores opt: 455 z-score: 456.5 E(): 5.9e-18 29.8%25 identity in 544 aa overlap. Also similar to the N-terminus of Streptomyces coelicolor TR:O69947(EMBL:AL023862) hypothetical 133.5 kd protein%2C SC3F9.07 (1238 aa)%2C fasta scores opt: 3612 z-score: 3597.9 E(): 0 63.9%25 identity in 831 aa overlap. Note%2C the last 131 aa of this CDS are identical to those in the analogous position on the adjoining CDS%2C SC2H12.10c. Contains a possible N-terminal signal sequence. Contains a Pfam match to entry PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain%2C 3 copies. Contains a TTA leucine gene gene7275 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7212 SCO7213 SCO7213 SC2H12.12 SC2H12.12 8017040 8017786 + hypothetical protein SC2H12.12%2C unknown%2C len: 248 aa. Similar to Streptomyces coelicolor TR:CAB89463(EMBL:AL354048) fatty acid synthase%2C SCE25.32C (438 aa)%2C fasta scores opt: 195 z-score: 237.4 E(): 9.5e-06 26.3%25 identity in 232 aa overlap. Also highly similar to Escherichia coli SW:YJHP_ECOLI(EMBL:U14003) hypothetical 27.4 kd protein (248 aa)%2C fasta scores opt: 1174 z-score: 1413.2 E():0 66.5%25 identity in 248 aa overlap. gene gene7276 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7213 SCO7214 SCO7214 SC2H12.13c SC2H12.13c 8017954 8019021 - hypothetical protein SC2H12.13c%2C possible integral membrane protein%2C len: 355 aa. Similar to several proteins of unknown function e.g. Streptomyces coelicolor TR:Q9S290(EMBL:AL096849) membrane protein%2C SCI11.29 (354 aa)%2C fasta scores opt: 1082 z-score: 1169.9 E():0 47.4%25 identity in 350 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7277 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7214 SCO7215 SCO7215 SC2H12.14c SC2H12.14c 8019248 8019808 - hypothetical protein SC2H12.14c%2C hypothetical protein%2C len: 186 aa. Similar to Deinococcus radiodurans TR:Q9RRF8(EMBL:AE002082) hypothetical protein%2C GrpB (188 aa)%2C fasta scores opt: 281 z-score: 356.9 E(): 2.1e-12 35.9%25 identity in 184 aa overlap and to SW:YI88_BACHD (EMBL:AP001513) Bacillus halodurans hypothetical protein BH1888%2C 195 aa%3B fasta scores: opt: 471 Z-score: 557.2 E(): 2.1e-23%3B 41.361%25 identity in 191 aa overlap gene gene7278 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7215 SCO7216 SCO7216 SC2H12.15 SC2H12.15 8020184 8021290 + FecCD-family membrane transport protein SC2H12.15%2C possible FecCD-family membrane transport protein%2C len: 368 aa. Highly similar to many including: Yersinia pestis SW:HMUU_YERPE(EMBL:U60647) hemin transport system permease HmuU (334 aa)%2C fasta scores opt: 674 z-score: 713.5 E(): 2.9e-32 40.4%25 identity in 342 aa overlap and Streptomyces coelicolor TR:Q9RKQ5(EMBL:AL133220) FecCD-family membrane transport protein%2C SCC75A.19 (363 aa)%2C fasta scores opt: 777 z-score: 820.7 E():0 42.6%25 identity in 371 aa overlap. Contains possible membrane spanning hydrophobic domains%2C a possible N-terminal signal sequence and a Pfam match to entry PF01032 FecCD_family%2C FecCD transport family. gene gene7279 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7216 SCO7217 SCO7217 SC2H12.16 SC2H12.16 8021287 8022063 + iron ABC transporter ATP-binding protein gene gene7280 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7217 SCO7218 SCO7218 SC2H12.17 SC2H12.17 8022130 8023167 + iron transport lipoprotein SC2H12.17%2C possible iron transport lipoprotein%2C len: 345 aa. Similar to Streptomyces coelicolor TR:Q9RK12(EMBL:AL109974) iron-siderophore binding lipoprotein%2C SCF34.13C (350 aa)%2C fasta scores opt: 221 z-score: 254.1 E(): 1.1e-06 28.7%25 identity in 352 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a Pfam match to entry PF01497 Peripla_BP_2%2C Periplasmic binding protein gene gene7281 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7218 SCO7219 SCO7219 SC2H12.18c SC2H12.18c 8023216 8023842 - phosphoglycerate mutase SC2H12.18c%2C possible phosphoglycerate mutase%2C len: 208 aa. Similar to Deinococcus radiodurans TR:Q9RUJ3(EMBL:AE001985) phosphoglycerate mutase (237 aa)%2C fasta scores opt: 143 z-score: 182.9 E(): 0.01 31.5%25 identity in 222 aa overlap. Contains 2xPfam matches to entry PF00300 PGAM%2C Phosphoglycerate mutase family. gene gene7282 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7219 SCO7220 SCO7220 SC2H12.19c SC2H12.19c 8023944 8025947 - hypothetical protein SC2H12.19c%2C unknown%2C len: 667 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:Q9RJC6(EMBL:AL133171) SCF81.26 (835 aa)%2C opt: 1057 z-score: 1135.5 E():0 38.6%25 identity in 643 aa overlap. gene gene7283 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7220 SCO7221 SCO7221 SC2H12.20c SC2H12.20c 8026306 8027475 - polyketide synthase SC2H12.20c%2C possible polyketide synthase%2C len: 389 aa. Weakly similar to several proteins from Eukaryotes and Prokaryotes involved in secondary metabolism e.g. Hydrangea macrophylla SW:CHSY_HYDMC(EMBL:AB011467) chalcone synthase (EC 2.3.1.74) a secondary plant metabolite (389 aa)%2C fasta scores opt: 294 z-score: 333.6 E(): 4.1e-11 28.4%25 identity in 282 aa overlap and Pseudomonas fluorescens TR:Q51725(EMBL:U41818) polyketide synthase PhlD (349 aa)%2C fasta scores opt: 433 z-score: 489.6 E(): 8.5e-20 26.4%25 identity in 386 aa overlap. Contains a Pfam match to entry PF00195 Chal_stil_synt%2C Chalcone and stilbene synthases. gene gene7284 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7221 SCO7222 SCO7222 SC2H12.21c SC2H12.21c 8027802 8028512 - TetR family transcriptional regulator SC2H12.21c%2C possible TetR-family transcriptional regulator%2C len: 236 aa. Similar to several including: Escherichia coli SW:TER1_ECOLI (EMBL:X61367) tetracycline repressor protein class A (216 aa)%2C fasta scores opt: 183 z-score: 217.2 E(): 0.00013 28.2%25 identity in 209 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 36..57 (+4.19 SD). gene gene7285 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7222 SCO7223 SCO7223 SC2H12.22 SC2H12.22 8028659 8029780 + monooxygenase SC2H12.22%2C possible monooxygenase%2C len: 373 aa. Similar to many other monooxygenases e.g. Sphingomonas sp. TR:P96555(EMBL:AB000564) salicylate hydroxylase (395 aa)%2C fasta scores opt: 347 z-score: 390.9 E(): 2.7e-14 27.0%25 identity in 378 aa overlap and Streptomyces coelicolor TR:Q9RK22(EMBL:AL109974) monooxygenase%2C SCF34.03C (388 aa)%2C fasta scores opt: 998 z-score: 1113.7 E():0 47.2%25 identity in 343 aa overlap. Contains a Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. gene gene7286 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7223 SCO7224 SCO7224 SC2H12.23c SC2H12.23c 8029922 8030377 - hypothetical protein SC2H12.23c%2C possible integral membrane protein%2C len: 151 aa. Highly similar to several proteins of undefined function e.g. Haemophilus influenzae SW:Y886_HAEIN (EMBL:U32770) hypothetical protein (134 aa)%2C fasta scores opt: 232 z-score: 291.2 E(): 9.6e-09 35.6%25 identity in 135 aa overlap and Streptomyces coelicolor TR:CAB92826 (EMBL:AL356892) integral membrane protein%2C SCC8A.08 (153 aa)%2C fasta scores opt: 533 z-score: 650.1 E(): 9.8e-29 58.7%25 identity in 143 aa overlap. Contains possible membrane spanning hydrophobic domains gene gene7287 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7224 SCO7225 SCO7225 SC2H12.24 SC2H12.24 8030688 8031422 + chitinase SC2H12.24%2C chitinase%2C len: 244 aa. The N-terminal is highly similar to several chitin binding proteins e.g. Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (CHB2) (201 aa)%2C fasta scores opt: 181 z-score: 193.2 E(): 0.0027 38.4%25 identity in 203 aa overlap. The C-terminal is similar to many chitinases e.g. Streptomyces olivaceoviridis TR:CAB83055(EMBL:AJ276990) chitinase precursor (EC 3.2.1.14) (781 aa)%2C fasta scores opt: 322 z-score: 324.1 E(): 1.4e-10 36.5%25 identity in 167 aa overlap. Also highly similar to several Streptomyces coelicolor chitinases e.g. TR:Q9Z9M5(EMBL:AB017013) chitinase%2C ChiG (fragment) (172 aa)%2C fasta scores opt: 845 z-score: 846.9 E():0 67.4%25 identity in 172 aa overlap and TRO86614:(EMBL:AL031155) SC3A7.13 (252 aa)%2C fasta scores opt: 1060 z-score: 1056.1 E(): 0 75.8%25 identity in 252 aa overlap. Contains a G/D rich region between residues 171..187. Contains a possible N-terminal signal sequence gene gene7288 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7225 SCO7226 SCO7226 SC2H12.25 SC2H12.25 8031545 8031985 + hypothetical protein SC2H12.25%2C possible integral membrane protein%2C len: 146 aa. Similar to several proteins of unproven function e.g. Streptomyces coelicolor TR:Q9X9Z5(EMBL:AL079332) integral membrane protein%2C SCI5.05C (143 aa)%2C fasta scores opt: 321 z-score: 398.2 E(): 1.1e-1437.4%25 identity in 139 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene7289 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7226 SCO7227 SCO7227 SC2H12.26 SC2H12.26 8031982 8033013 + hypothetical protein SC2H12.26%2C possible hypothetical protein%2C len: 343 aa. Highly similar to many proteins of undefined function e.g. Escherichia coli SW:YBBK_ECOLI(EMBL:AE000155) (305 aa)%2C fasta scores opt: 705 z-score: 738.7 E():0 42.2%25 identity in 301 aa overlap and Streptomyces coelicolor TR:Q9X9Z6(EMBL:AL079332) SCI5.04C (319 aa)%2C fasta scores opt: 1209 z-score: 1258.9 E():0 61.9%25 identity in 281 aa overlap. Contains a possible N-terminal signal sequence. Also contains a Prosite hit to PS01270 Band 7 protein family signature and a Pfam match to entry PF01145 Band_7%2C SPFH domain / Band 7 family gene gene7290 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7227 SCO7228 SCO7228 SC2H12.27c SC2H12.27c 8033017 8034681 - polysaccharide lyase SC2H12.27c%2C possible polysaccharide lyase%2C len: 554 aa. Similar to regions within several pectate lyases e.g. Erwinia chrysanthemi SW:PELX_ERWCH(EMBL:M62739) exopolygalacturonate lyase precursor (EC 4.2.2.9)%2C PelX (749 aa)%2C fasta scores opt: 441 z-score: 462.5 E(): 2.7e-18 33.2%25 identity in 455 aa overlap. gene gene7291 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7228 SCO7229 SCO7229 SC2H12.28c SC2H12.28c 8034753 8035697 - hypothetical protein SC2H12.28c%2C possible membrane protein%2C len: 314 aa. Similar to Streptomyces coelicolor TR:Q9XAG2(EMBL:AL079356) possible membrane protein%2C SC6G9.20 (303 aa)%2C fasta scores opt: 826 z-score: 786.1 E():0 47.1%25 identity in 308 aa overlap and Mycobacterium tuberculosis TR:O05859(EMBL:Z95120) hypothetical 31.0 kd protein (285 aa)%2C fasta scores opt: 341 z-score: 332.4 E(): 4.9e-11 29.7%25 identity in 296 aa overlap. Contains a possible membrane spanning hydrophobic domain. gene gene7292 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7229 SCO7230 SCO7230 SC2H12.29 SC2H12.29 8035811 8036500 + two-component system response regulator SC2H12.29%2C possible two-component system response regulator%2C len: 229 aa. Highly similar to many other two-component system regulators e.g. Mycobacterium bovis SW:RGX3_MYCBO (EMBL:Y13627) sensory transduction protein%2C RegX3 (227 aa)%2C fasta scores opt: 609 z-score: 727.0 E(): 0 44.7%25 identity in 226 aa overlap and Streptomyces coelicolor TR:CAB90891 (EMBL:AL355753) two-component system response regulator protein%2C SC8G12.09 (233 aa)%2C fasta scores opt: 953 z-score: 1131.9 E(): 0 63.4%25 identity in 235 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and a Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal. gene gene7293 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7230 SCO7231 SCO7231 SC2H12.30 SC2H12.30 8036497 8038008 + two-component system sensor kinase SC2H12.30%2C possible two-component system sensor kinase%2C len: 503 aa. Highly similar to many other sensor kinases e.g. Streptomyces coelicolor SW:AFQ2_STRCO (EMBL:D10654) sensor protein%2C AfsQ2%2C a regulator of secondary metabolism (EC 2.7.3.-) (535 aa)%2C fasta scores opt: 1112 z-score: 1254.8 E():0 42.0%25 identity in 519 aa overlap. Contains Pfam matches to entries PF00672 DUF5%2C Domain found in bacterial signal proteins and PF00512 signal%2C Histidine kinase. Contains possible membrane spanning hydrophobic domains. gene gene7294 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7231 SCO7232 SCO7232 SC2H12.31 SC2H12.31 8038005 8038640 + hypothetical protein SC2H12.31%2C possible hypothetical protein%2C len: 211 aa. Similar to Streptomyces coelicolor TR:CAB90893(EMBL:AL355753) lipoprotein%2C SC8G12.11 (187 aa)%2C fasta scores opt: 176 z-score: 196.2 E(): 0.0019 32.8%25 identity in 189 aa overlap. Contains a possible N-terminal signal sequence. gene gene7295 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7232 SCO7233 SCO7233 SC2H12.32 SC2H12.32 8038819 8041623 + hypothetical protein SC2H12.32%2C possible hypothetical protein%2C len: 934 aa. Note the product of this CDS is rich in the amino acid proline. Contains a possible N-terminal signal sequence. Contains a TTA /leucine codon%2C possible target for bldA regulation. gene gene7296 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7233 SCO7234 SCO7234 ctaD ctaD 8041721 8043442 + cytochrome C oxidase polypeptide I SC2H12.33%2C ctaD%2C cytochrome C oxidase polypeptide I (EC 1.9.3.1)%2C len: 573 aa. Highly similar to many e.g. Bacillus subtilis SW:COX1_BACSU(EMBL:X54140) cytochrome C oxidase polypeptide I (EC 1.9.3.1) CtaD (621 aa)%2C fasta scores opt: 1725 z-score: 1882.8 E():0 47.7%25 identity in 524 aa overlap and Streptomyces coelicolor TR:Q9X813(EMBL:AL049497) cytochrome C oxidase subunit I (EC 1.9.3.1)%2C SC6G10.28C (578 aa)%2C fasta scores opt: 3002 z-score: 3275.1 E():0 75.6%25 identity in 541 aa overlap. Contains a Prosite hit to PS00077 Heme-copper oxidase catalytic subunit%2C copper B binding region signature and a Pfam match to entry PF00115 COX1%2C Cytochrome C and Quinol oxidase polypeptide I. Also contains multiple possible membrane spanning hydrophobic domains gene gene7297 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7234 SCO7235 SCO7235 SC2H12.34 SC2H12.34 8043439 8043849 + hypothetical protein SC2H12.34%2C possible integral membrane protein%2C partial CDS%2C len: >86 aa. Highly similar to proteins of unknown function from: Mycobacterium tuberculosis SW:YL99_MYCTU(EMBL:Z70283) (139 aa)%2C fasta scores opt: 200 z-score: 283.7 E(): 2.5e-08 45.6%25 identity in 90 aa overlap and Streptomyces coelicolor TR:Q9X812(EMBL:AL049497) integral membrane protein%2C SC6G10.27C (132 aa)%2C fasta scores opt: 245 z-score: 344.5 E(): 1e-11 43.0%25 identity in 86 aa overlap. Contains possible membrane spanning hydrophobic domains. Overlaps and extends into CDS SC7A12.02 on the adjoining cosmid.~SC7A12.02%2C possible integral membrane protein%2C len: 136 aa. Highly similar to Streptomyces coelicolor TR:Q9X812(EMBL:AL049497) integral membrane protein%2C SC6G10.27C (132 aa)%2C fasta scores opt: 333 z-score: 421.2 E(): 5.4e-16 39.4%25 identity in 132 aa overlap and Mycobacterium tuberculosis TR:Y00A_MYCTU(EMBL:Z70283) hypothetical 14.9 kd protein (139 aa)%2C fasta scores opt: 284 z-score: 361.2 E(): 1.2e-12 43.4%25 identity in 129 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7298 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7235 SCO7236 SCO7236 qcrB3 qcrB3 8043825 8045489 - ubiquinol-cytochrome C reductase cytochrome subunit B SC7A12.03c%2C qcrB3%2C ubiquinol-cytochrome C reductase cytochrome subunit B%2C len: 554 aa. Highly similar to many including: Streptomyces lividans SW:QCRB_STRLI(EMBL:AF107888) ubiquinol-cytochrome C reductase cytochrome subunit B (549 aa)%2C fasta scores opt: 1808 z-score: 1914.0 E():0 51.9%25 identity in 528 aa overlap and Streptomyces coelicolor SW:QCRB_STRCO (EMBL:AL049497) ubiquinol-cytochrome C reductase cytochrome subunit B%2C QcrB OR SC6G10.21c (545 aa)%2C opt: 2016 z-score: 2133.7 E():0 55.0%25 identity in 522 aa overlap. Contains a Pfam match to entry PF00033 cytochrome_b_N%2C Cytochrome b(N-terminal)/b6/petB and multiple possible membrane spanning hydrophobic domains. gene gene7299 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7236 SCO7237 SCO7237 SC7A12.04c SC7A12.04c 8045564 8045923 - hypothetical protein SC7A12.04c%2C possible hypothetical protein%2C len: 119 aa. Contains a possible N-terminal signal sequence. gene gene7300 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7237 SCO7238 SCO7238 SC7A12.05 SC7A12.05 8046083 8046460 + hypothetical protein SC7A12.05%2C unknown%2C len: 125 aa. Similar to Streptomyces coelicolor TR:Q9X8F4(EMBL:AL049573) hypothetical 14.3 kd protein%2C SCE39.31C (136 aa)%2C fasta scores opt: 247 z-score: 310.9 E(): 7.6e-10 37.2%25 identity in 121 aa overlap. gene gene7301 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7238 SCO7239 SCO7239 SC7A12.06 SC7A12.06 8046501 8047403 + hypothetical protein SC7A12.06%2C unknown%2C len: 300 aa. Weakly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:P94979(EMBL:Z85982) hypothetical 39.9 kd protein (351 aa)%2C fasta scores opt: 271 z-score: 321.1 E(): 2.1e-10 26.2%25 identity in 309 aa overlap. Also similar to TR:Q9HV65 (EMBL:AE004887) Pseudomonas aeruginosa hypothetical protein PA4734%2C 293 aa%3B fasta scores: opt: 497 Z-score: 565.3 E(): 7.4e-24%3B 40.727%25 identity in 275 aa overlap gene gene7302 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7239 SCO7240 SCO7240 SC7A12.07 SC7A12.07 8047425 8049662 + Ser/Thr protein kinase SC7A12.07%2C possible Ser/Thr protein kinase%2C len: 745 aa. Similar to many kinases including: Myxococcus xanthus SW:PKN2_MYXXA (EMBL:M94857) Ser/Thr protein kinase (EC 2.7.1.-) (830 aa)%2C fasta scores opt: 653 z-score: 572.5 E(): 2e-24 31.1%25 identity in 636 aa overlap and Streptomyces coelicolor TR:Q9XA57(EMBL:AL096822) Ser/Thr protein kinase%2C SCGD3.21C (522 aa)%2C fasta scores opt: 700 z-score: 615.9 E(): 7.7e-27 37.1%25 identity in 407 aa overlap. Contains a Prosite hit to PS00107 Protein kinases ATP-binding region signature and a Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain. Note this CDS contains a degenerate repeat region between residues 376..735 gene gene7303 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7240 SCO7241 SCO7241 SC7A12.08 SC7A12.08 8049672 8051294 + oxidoreductase SC7A12.08%2C possible oxidoreductase%2C len: 540 aa. Similar to many including: Streptomyces griseus SW:CRTI_STRGR(EMBL:L37405) phytoene dehydrogenase (EC 1.3.-.-) (507 aa)%2C fasta scores opt: 175 z-score: 191.7 E(): 0.0033 27.0%25 identity in 529 aa overlap and Mycobacterium tuberculosis SW:Y897_MYCTU(EMBL:Z73101) hypothetical 56.2 kda protein (535 aa)%2C fasta scores opt: 1633 z-score: 1765.0 E():0 52.0%25 identity in 527 aa overlap. Contains a Pfam match to entry PF02032 Phytoene_dh%2C Phytoene dehydrogenase related enzyme. gene gene7304 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7241 SCO7242 SCO7242 SC7A12.09 SC7A12.09 8051378 8051503 + hypothetical protein SC7A12.09%2C doubtful CDS%2C len: 41 aa. gene gene7305 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7242 SCO7243 SCO7243 SC7A12.10c SC7A12.10c 8051543 8053336 - hypothetical protein SC7A12.10c%2C possible hypothetical protein%2C len: 597 aa. Similar to Streptomyces coelicolor TR:Q9RKP5(EMBL:AL133220) possible esterase%2C SCC75A.29C (351 aa)%2C fasta scores opt: 955 z-score: 1080.4 E():0 53.5%25 identity in 357 aa overlap. Contains a possible N-terminal signal sequence gene gene7306 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7243 SCO7244 SCO7244 SC7A12.11 SC7A12.11 8053492 8055009 + acyl-CoA synthetase activates fatty acids by binding to coenzyme A gene gene7307 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7244 SCO7245 SCO7245 SC7A12.12 SC7A12.12 8055078 8055983 + hydrolase SC7A12.12%2C possible hydrolase%2C len: 301 aa. Similar to Lactobacillus helveticus SW:PIP_LACHE(EMBL:Z56283) proline iminopeptidase (EC 3.4.11.5) (294 aa)%2C fasta scores opt: 254 z-score: 284.0 E(): 2.4e-08 27.5%25 identity in 262 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene7308 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7245 SCO7246 SCO7246 SC7A12.13 SC7A12.13 8056020 8056262 + hypothetical protein SC7A12.13%2C unknown%2C len: 80 aa. Highly similar to Streptomyces coelicolor TR:Q53896 (EMBL:X60316) pleiotropic antibiotic regulatory locus AbaA%2C OrfD (75 aa)%2C fasta scores opt: 195 z-score: 288.2 E(): 1.4e-08 45.8%25 identity in 72 aa overlap. gene gene7309 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7246 SCO7247 SCO7247 SC7A12.14 SC7A12.14 8056347 8057249 + hypothetical protein SC7A12.14%2C unknown%2C len: 300 aa. Similar to many proteins of undefined function including: Streptomyces coelicolor TR:Q9RIZ8 (EMBL:AL109962) conserved hypothetical protein%2C SCJ1.16C (294 aa)%2C fasta scores opt: 524 z-score: 574.4 E(): 1.6e-24 38.8%25 identity in 309 aa overlap and Mycobacterium tuberculosis TR:O06188 (EMBL:Z95387) hypothetical protein (272 aa)%2C fasta scores opt: 240 z-score: 268.6 E(): 1.7e-07 28.6%25 identity in 290 aa overlap. Contains a 2x Pfam matches to entries PF00582 Usp%2C Universal stress protein family gene gene7310 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7247 SCO7248 SCO7248 SC7A12.15 SC7A12.15 8057268 8057888 + hypothetical protein SC7A12.15%2C unknown%2C len: 206 aa. Weakly similar to several proteins of undefined function e.g. Streptomyces coelicolor TR:CAB72201(EMBL:AL138851) SCE59.14C (196 aa)%2C fasta scores opt: 209 z-score: 240.8 E(): 6.1e-06 33.7%25 identity in 193 aa overlap. gene gene7311 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7248 SCO7249 SCO7249 SC7A12.16 SC7A12.16 8057947 8058444 + hypothetical protein SC7A12.16%2C unknown%2C len: 165 aa. gene gene7312 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7249 SCO7250 SCO7250 SC7A12.17c SC7A12.17c 8058466 8060385 - hypothetical protein SC7A12.17c%2C unknown%2C len: 639 aa. Highly similar to another hypothetical protein: Streptomyces coelicolor TR:Q9S2M7(EMBL:AL109661) SC6E10.10 (943 aa)%2C fasta scores opt: 1245 z-score: 1258.0 E(): 0 42.5%25 identity in 664 aa overlap. Contains a Pfam match to entry PF01510 Amidase_2%2C N-acetylmuramoyl-L-alanine amidase. gene gene7313 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7250 SCO7251 SCO7251 SC5H1.41 SC5H1.41 8060696 8061733 - hypothetical protein SC5H1.41%2C hypothetical protein%2C len: 345 aa%3B unknown function%2C similar to part of TR:Q9Z4Z7 (EMBL:AL035707) S.coelicolor phosphotransferase SCE29.03 (300 aa)%2C fasta scores%3B opt: 433 z-score: 437.4 E(): 4.9e-17%2C 37.2%25 identity in 269 aa overlap. Contains TTA (leucine) codon%2C possible target for bldA regulation. There are imperfect inverted repeats at each end of the CDS gene gene7314 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7251 SCO7252 SCO7252 SC5H1.40c SC5H1.40c 8062135 8063643 + regulatory protein SC5H1.40c%2C possible regulatory protein%2C len: 502 aa%3B similar to e.g. SW:SP15_STRGR (EMBL:M32687) Streptomyces griseus sporulation protein (529 aa)%2C fasta scores%3B opt: 394 z-score: 452.2 E(): 7.2e-18%2C 27.9%25 identity in 530 aa. Similar to SC7A1.26 (EMBL:AL034447) S.coelicolor possible transcriptional regulator (500 aa) (43.0%25 identity in 491 aa overlap) gene gene7315 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7252 SCO7253 SCO7253 SC5H1.39 SC5H1.39 8063663 8064979 - hypothetical protein SC5H1.39%2C hypothetical protein%2C len: 438 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene7316 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7253 SCO7254 SCO7254 SC5H1.38 SC5H1.38 8065252 8066280 - myo-inositol dehydrogenase SC5H1.38%2C probable myo-inositol dehydrogenase%2C len: 342 aa%3B similar to many e.g. SW:MI2D_BACSU (EMBL:M76431)%2C idh%2C Bacillus subtilis myo-inositol 2-dehydrogenase (344 aa)%2C fasta scores%3B opt: 864 z-score: 958.5 E(): 0%2C 38.1%25 identity in 336 aa overlap. Also similar to SW:STRI_STRGR (EMBL:Y00459)%2C strI%2C Streptomyces griseus streptomycin biosynthesis myo-inositol oxidoreductase (348 aa) (32.7%25 identity in 343 aa overlap). Weakly similar to TR:O69945 (EMBL:AL023862) S.coelicolor possible oxidoreductase (430 aa) (29.8%25 identity in 228 aa overlap). Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family%2C score 153.50%2C E-value 3.6e-42 gene gene7317 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7254 SCO7255 SCO7255 SC5H1.37 SC5H1.37 8066404 8067498 - hypothetical protein SC5H1.37%2C hypothetical protein%2C len: 364 aa%3B unknown function%2C similar to TR:P73120 (EMBL:D90903) Synechocystis sp. hypothetical protein (358 aa)%2C fasta scores%3B opt: 492 z-score: 559.6 E(): 7.6e-24%2C 31.6%25 identity in 364 aa overlap gene gene7318 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7255 SCO7256 SCO7256 SC5H1.36 SC5H1.36 8067580 8069211 - protease SC5H1.36%2C probable protease (hypothetical protein)%2C len: 543 aa%3B similar to many e.g. TR:Q54398 (EMBL:L42758)%2C SlpD%2C Streptomyces lividans protease%2C (539 aa)%2C fasta scores%3B opt: 697 z-score: 769.7 E(): 0%2C35.8%25 identity in 545 aa overlap. Similar to other S.coelicolor proteases e.g. SlpD%2C SCH5.02c (EMBL:AL03563) proteinase (539 aa) (35.8%25 identity in 545 aa overlap). Contains possible N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold%2C score 55.00%2C E-value 1.6e-12 gene gene7319 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7256 SCO7257 SCO7257 SC5H1.35c SC5H1.35c 8069445 8070158 + hypothetical protein SC5H1.35c%2C possible hypothetical protein%2C len: 237 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis%2C amino acid composition and the presence of a possible RBS. Similar to TR:Q9AD93 (EMBL:AL590507) Streptomyces coelicolor hypothetical protein SCI52.16c%2C 259 aa%3B fasta scores: opt: 566 Z-score: 492.9 E(): 8e-20%3B 46.154%25 identity in 260 aa overlap. Contains possible N-terminal peptide signal sequence gene gene7320 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7257 SCO7258 SCO7258 SC5H1.34 SC5H1.34 8070206 8070691 - hypothetical protein SC5H1.34%2C conserved hypothetical protein%2C len: 161 aa%3B unknown function%2C similar to hypothetical proteins e.g. TR:O59834 (EMBL:AL023590) Schizosaccaromyces pombe hypothetical protein (162 aa)%2C fasta scores%3B opt: 224 z-score: 282.3 E(): 2.1e-08%2C 28.6%25 identity in 161 aa overlap and weakly similar to SW:FCA1_CANAL (EMBL:U55194)%2C fca1%2C Candida albicans cytosine deaminase (150 aa) (30.1%25 identity in 93 aa overlap) gene gene7321 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7258 SCO7259 SCO7259 SC5H1.33c SC5H1.33c 8070834 8071793 + hypothetical protein SC5H1.33c%2C hypothetical protein%2C len: 319 aa%3B unknown function%2C similar to TR:O33938 (EMBL:Y11199) eryBIV%2C Saccharopolyspora erythraea deoxyhexose reductase involved in mycarose biosynthesis (322 aa)%2C fasta scores%3B opt: 174 z-score: 200.8 E(): 0.00073%2C 28.7%25 identity in 282 aa overlap gene gene7322 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7259 SCO7260 SCO7260 SC5H1.32 SC5H1.32 8071805 8072074 - hypothetical protein SC5H1.32%2C possible membrane protein%2C len: 89 aa%3B unknown function%2C similar to e.g. SW:YEAQ_ECOLI (EMBL:AE000274)%2C yeaQ%2C Escherichia coli hypothetical protein (82 aa)%2C fasta scores%3B opt: 180 z-score: 242.2 E(): 3.6e-06%2C 35.2%25 identity in 71 aa overlap gene gene7323 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7260 SCO7261 SCO7261 SC5H1.31 SC5H1.31 8072211 8072654 - hypothetical protein SC5H1.31%2C possible membrane protein%2C len: 147 aa%3B unknown function%2C similar to TR:O07432 (EMBL:Z97050) Mycobacterium tuberculosis hypothetical protein (143 aa)%2C fasta scores%3B opt: 326 z-score: 414.4 E(): 9.2e-16%2C 36.2%25 identity in 141 aa overlap gene gene7324 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7261 SCO7262 SCO7262 SC5H1.30c SC5H1.30c 8072945 8073109 + hypothetical protein SC5H1.30c%2C hypothetical protein%2C len: 54 aa%3B unknown function%2C possible short CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene7325 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7262 SCO7263 SCO7263 chiF chiF 8073282 8074172 + chitinase SC5H1.29c%2C chiF%2C chitinase%2C len: 296 aa%3B previously sequenced as chiF (EMBL:AB017012) and similar to many e.g. TR:O50152 (EMBL:AB009289)%2C chiC%2C Streptomyces griseus chitinase C (294 aa)%2C fasta scores%3B opt: 1308 z-score: 1506.5 E(): 0%2C 65.8%25 identity in 295 aa overlap. Contains possible N-terminal signal sequence. Contains Pfam match to entry PF00182 chitinase_1%2C Chitinases class I%2C score 247.20%2C E-value 2.2e-70 gene gene7326 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7263 SCO7264 SCO7264 SC5H1.28c SC5H1.28c 8074183 8075100 + oxidoreductase SC5H1.28c%2C probable oxidoreductase%2C len: 305 aa%3B similar to many e.g. SW:MORA_PSEPU (EMBL:Q02198)%2C morA%2C Pseudomonas putida morphine 6-dehydrogenase (295 aa)%2C fasta scores%3B opt: 235 z-score: 281.5 E(): 2.3e-08%2C 28.1%25 identity in 274 aa overlap gene gene7327 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7264 SCO7265 SCO7265 SC5H1.27 SC5H1.27 8075475 8076074 - hypothetical protein SC5H1.27%2C hypothetical protein%2C len: 199 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene7328 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7265 SCO7266 SCO7266 SC5H1.26 SC5H1.26 8076071 8076808 - 3-oxoacyl-ACP reductase SC5H1.26%2C probable 3-oxoacyl-[acyl-carrier protein] reductase%2C len: 245 aa%3B similar to many short-chain oxidoreductases e.g. SW:FABG_BACSU (EMBL:U59433)%2C FabG%2C Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase (246 aa)%2C fasta scores%3B opt: 521 z-score: 562.5 E(): 5.2e-24%2C 36.6%25 identity in 246 aa overlap and SW:DHG2_BACME (EMBL:D90044)%2C GdhII%2C Bacillus megaterium glucose 1-dehydrogenase II (261 aa) (35.3%25 identity in 249 aa overlap). Similar to SCE134.03c (EMBL:AL049661) possible short chain dehydrogenase (255 aa) (35.1%25 identity in 242 aa overlap). Contains Pfam matches to entry PF00106 adh_short%2C short chain dehydrogenase%2C score 220.40%2C E-value 2.7e-62 and entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus%2C score 44.40%2C E-value 2.6e-09 gene gene7329 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7266 SCO7267 SCO7267 SC5H1.25c SC5H1.25c 8077041 8077436 + hypothetical protein SC5H1.25c%2C conserved hypothetical protein%2C len: 131 aa%3B similar to e.g. SW:YFC3_SHEPU (EMBL:L04283) Shewanella putrefaciens hypothetical protein (118 aa)%2C fasta scores%3B opt: 372 z-score: 466.1 E(): 1.2e-18%2C 52.2%25 identity in 115 aa overlap. Weakly similar to some lyases e.g. SW:LGUL_SALTY (EMBL:U57364)%2C gloA%2C Salmonella typhimurium lactoylglutathione lyase (135 aa) (23.6%25 identity in 127 aa overlap). Also similar to TR:O86701 (EMBL:AL031515) S.coelicolor possible lyase (138 aa) (33.1%25 identity in 127 aa overlap) gene gene7330 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7267 SCO7268 SCO7268 add add 8077471 8078550 + adenosine deaminase catalyzes the formation of inosine from adenosine gene gene7331 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7268 SCO7269 SCO7269 SC5H1.23 SC5H1.23 8078532 8079047 - hypothetical protein SC5H1.23%2C hypothetical protein%2C len: 171 aa%3B unknown function%2C similar to TR:O53728 (EMBL:AL021932) Mycobacterium tuberculosis hypothetical protein (171 aa)%2C fasta scores%3B opt: 561 z-score: 716.6 E(): 1.4e-32%2C 49.7%25 identity in 165 aa overlap gene gene7332 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7269 SCO7270 SCO7270 SC5H1.22 SC5H1.22 8079088 8079972 - transcriptional regulator SC5H1.22%2C probable transcriptional regulator%2C len: 294 aa%3B similar to many LysR family regulators e.g. SW:BUDR_KLETE (EMBL:Z48600)%2C budR%2C Klebsiella terrigena bud operon transcriptional regulator (290 aa)%2C fasta scores%3B opt: 392 z-score: 459.0 E(): 3.1e-18%2C 33.7%25 identity in 267 aa overlap. Similar to TR:O86805 (EMBL:AL031317) S.coelicolor probable transcriptional regulator (306 aa) (29.3%25 identity in 304 aa overlap). Contains probable helix-turn-helix motif at aa 17-38 (Score 1145%2C +3.09 SD). Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix proteins%2C lysR family%2C score 171.10%2C E-value 1.9e-47 and PS00044 Bacterial regulatory proteins%2C lysR family signature gene gene7333 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7270 SCO7271 SCO7271 SC5H1.21c SC5H1.21c 8080134 8081093 + ion channel subunit SC5H1.21c%2C probable ion channel subunit%2C len: 319 aa%3B similar to many eukaryotic potassium channel subunits e.g. TR:Q39151 (EMBL:L40948) Arabidopsis thaliana K+ channel protein (328 aa)%2C fasta scores%3B opt: 627 z-score: 726.8 E(): 0%2C 35.7%25 identity in 325 aa overlap. Weakly similar to SC5H1.06c%2C hypothetical protein (327 aa) (29.3%25 identity in 338 aa overlap) gene gene7334 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7271 SCO7272 SCO7272 SC5H1.20 SC5H1.20 8081175 8081558 - isomerase SC5H1.20%2C possible isomerase%2C len: 127 aa%3B weakly similar to SW:SDIS_PSEPU (EMBL:L13127)%2C ksI%2C Pseudomonas putida steroid delta-isomerase (131 aa)%2C fasta scores%3B opt: 109 z-score: 150.4 E(): 0.47%2C 26.0%25 identity in 131 aa overlap gene gene7335 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7272 SCO7273 SCO7273 SC5H1.19c SC5H1.19c 8081893 8082303 + hypothetical protein SC5H1.19c%2C hypothetical protein%2C len: 136 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains TTA (leucine) codon%2C possible target for bldA regulation gene gene7336 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7273 SCO7274 SCO7274 SC5H1.18 SC5H1.18 8082329 8083531 - hypothetical protein SC5H1.18%2C possible membrane protein%2C len: 400 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains hydrophobic%2C probable membrane-spanning regions gene gene7337 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7274 SCO7275 SCO7275 SC5H1.17 SC5H1.17 8083750 8084169 - hypothetical protein SC5H1.17%2C hypothetical protein%2C len: 138 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Contains region similar to adjacent CDS SC5H1.16%2C hypothetical protein (194 aa) (34.6%25 identity in 107 aa overlap) gene gene7338 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7275 SCO7276 SCO7276 SC5H1.16 SC5H1.16 8084166 8084750 - hypothetical protein SC5H1.16%2C hypothetical protein%2C len: 194 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition. Start codon position suggested by GC frame plot and possible RBS. Contains region similar to adjacent CDS%2C SC5H1.17%2C hypothetical protein (138 aa) (34.6%25 identity in 107 aa overlap) gene gene7339 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7276 SCO7277 SCO7277 SC5H1.15c SC5H1.15c 8084920 8085375 + regulator protein SC5H1.15c%2C possible regulator protein%2C len: 151 aa%3B similar to Streptomyces fradiae beta-lactamase regulator protein (EMBL:AB024056) (139 aa)%2C fasta scores%3B opt: 177 z-score: 241.8 E(): 3.8e-06%2C 35.2%25 identity in 122 aa overlap and TR:O54111 (EMBL:AL021529)%2C SC10A5.20%2C S.coelicolor hypothetical protein (171 aa) (35.4%25 identity in 99 aa overlap) gene gene7340 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7277 SCO7278 SCO7278 SC5H1.14 SC5H1.14 8085400 8086287 - RNA polymerase sigma factor SC5H1.14%2C probable RNA polymerase sigma factor%2C len: 295 aa%3B similar to many e.g. SW:RPOF_STRCO (EMBL:L11648)%2C SigF%2C RpoX%2C Streptomyces coelicolor RNA polymerase sigma-F factor (287 aa)%2C fasta scores%3B opt: 707 z-score: 817.4 E(): 0%2C 43.6%25 identity in 282 aa overlap. Contains probable helix-turn-helix motif at aa 258-279 (Score 2096%2C +6.33 SD). Contains Pfam match to entry PF00140 sigma70%2C Sigma-70 factors%2C score 230.40%2C E-value 2.6e-65 and PS00715 Sigma-70 factors family signature 1 gene gene7341 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7278 SCO7279 SCO7279 SC5H1.13c SC5H1.13c 8086495 8086968 + DNA-binding protein SC5H1.13c%2C possible DNA-binding protein%2C len: 157 aa%3B contains region similar to TR:O33287 (EMBL:AL008967) Mycobacterium tuberculosis possible transcriptional regulator (112 aa)%2C fasta scores%3B opt: 254 z-score: 260.9 E(): 3.3e-07%2C 50.0%25 identity in 94 aa overlap and TR:O86815 (EMBL:AL031031)%2C SC7C7.10%2C S.coelicolor hypothetical protein (126 aa) (55.6%25 identity in 72 aa overlap). Possible DNA-binding function as it contains probable helix-turn-helix motif at aa 77-98 (Score 1354%2C +3.80 SD) and Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix%2C score 41.30%2C E-value 2.2e-08. PQATR repeat present in proline-rich N-terminus gene gene7342 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7279 SCO7280 SCO7280 clpP4 clpP4 8087020 8087622 - ATP-dependent Clp protease proteolytic subunit 2 SC5H1.12%2C clpP4%2C probable ATP-dependent Clp protease proteolytic subunit 2%2C len: 200 aa%3B similar to many e.g. clpP2 (EMBL:AF071885) Streptomyces coelicolor ATP-dependent Clp protease proteolytic subunit 2 (236 aa)%2C fasta scores%3B opt: 716 z-score: 853.7 E(): 0%2C 56.0%25 identity in 193 aa overlap. Also similar to adjacent CDS%2C SC5H1.11%2C probable ATP-dependent Clp protease proteolytic subunit 1 (217 aa) (39.3%25 identity in 201 aa overlap). Contains Pfam match to entry PF00574 CLP_protease%2C Clp protease%2C score 268.60%2C E-value 8.1e-77 gene gene7343 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7280 SCO7281 SCO7281 clpP3 clpP3 8087624 8088277 - ATP-dependent Clp protease proteolytic subunit hydrolyzes proteins to small peptides%3B with the ATPase subunits ClpA or ClpX%2C ClpP degrades specific substrates gene gene7344 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7281 SCO7282 SCO7282 SC5H1.10c SC5H1.10c 8088496 8088978 + DNA-binding protein SC5H1.10c%2C hypothetical protein%2C len: 160 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis%2C amino acid composition and the presence of a possible RBS%3B similar to TR:Q98C01 (EMBL:AP003006) Rhizobium loti (Mesorhizobium loti) MLL5357 protein%2C 156 aa%3B fasta scores: opt: 617 Z-score: 752.0 E(): 2.9e-34%3B 58.170%25 identity in 153 aa overlap. Contains probable helix-turn-helix motif at aa 104-125 (Score 1006%2C +2.61 SD) gene gene7345 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7282 SCO7283 SCO7283 SC5H1.09c SC5H1.09c 8089106 8089903 + hydroxylase SC5H1.09c%2C possible hydroxylase%2C len: 265 aa%3B similar to e.g. TR:Q55078 (EMBL:U50973)%2C doxA%2C Streptomyces sp. daunomycin C-14 hydroxylase (275 aa)%2C fasta scores%3B opt: 440 z-score: 519.4 E(): 1.3e-21%2C 37.5%25 identity in 259 aa overlap. Similar to SC9B10.20c (EMBL:AL009204) S.coelicolor hypothetical protein (267 aa) (34.1%25 identity in 249 aa overlap) gene gene7346 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7283 SCO7284 SCO7284 rnhA rnhA 8089935 8090642 + ribonuclease H SC5H1.08c%2C rnhA%2C probable ribonuclease H%2C len: 235 aa%3B similar to many e.g. SW:RNH_THETH (EMBL:X60507)%2C rhnA%2C Thermus aquaticus ribonuclease H (166 aa)%2C fasta scores%3B opt: 299 z-score: 312.2 E(): 4.6e-10%2C 38.0%25 identity in 166 aa overlap. Also similar to TR:Q54388 (EMBL:X95703)%2C rnhH%2C Streptomyces lincolnensis ribonuclease H (117 aa) (89.7%25 identity in 117 aa overlap). Has a C-terminal extension not present in the Thermus aquaticus enzyme. Contains Pfam match to entry PF00075 rnaseH%2C RNase H%2C score 52.60%2C E-value 8.9e-12 gene gene7347 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7284 SCO7285 SCO7285 SC5H1.07c SC5H1.07c 8090745 8092010 + hydroxylase SC5H1.07c%2C possible hydroxylase%2C len: 421 aa%3B weakly similar to many e.g. TR:P96555 (EMBL:AB000564) Sphingomonas sp. salicylate hydroxylase (395 aa)%2C fasta scores%3B opt: 188 z-score: 216.6 E(): 9.6e-05%2C 26.5%25 identity in 359 aa overlap and TR:Q53657 (EMBL:D38214)%2C Cts8%2C Streptomyces aureofaciens 6-hydroxylation enzyme of tetracycline (469 aa) (25.9%25 identity in 347 aa overlap). Weakly similar to SCE29.14c (EMBL:AL035707) S.coelicolor possible salicylate hydroxylase (420 aa) (29.3%25 identity in 372 aa overlap). Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase%2C score 42.50%2C E-value 9.2e-09 gene gene7348 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7285 SCO7286 SCO7286 SC5H1.06c SC5H1.06c 8092023 8093006 + oxidoreducatse SC5H1.06c%2C hypothetical protein%2C len: 327 aa%3B weakly similar e.g. SW:GS69_BACSU (EMBL:Y14082)%2C YhdN%2C Bacillus subtilis general stress protein 69 (331 aa)%2C fasta scores%3B opt: 419 z-score: 477.8 E(): 2.7e-19%2C 29.3%25 identity in 328 aa overlap and TR:Q40648 (EMBL:U46758)%2C kob1%2C Oryza sativa potassium channel beta subunit protein (326 aa) (27.9%25 identity in 341 aa overlap). Weakly similar to SC5H1.21c%2C probable ion channel subunit (319 aa) (29.3%25 identity in 338 aa overlap) gene gene7349 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7286 SCO7287 SCO7287 SC5H1.05 SC5H1.05 8093034 8093387 - hypothetical protein SC5H1.05%2C hypothetical protein%2C len: 117 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and amino acid composition gene gene7350 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7287 SCO7288 SCO7288 SC5H1.04c SC5H1.04c 8093542 8094045 + hypothetical protein SC5H1.04c%2C possible membrane protein%2C len: 167 aa%3B unknown function%2C probable CDS suggested by positional base preference%2C GC frame analysis and the presence of a possible RBS%3B similar to TR:Q9AJX8 (EMBL:AL512944) Streptomyces coelicolor integral membrane protein SC8D11.43c%2C 184 aa%3B fasta scores: opt: 505 Z-score: 606.1 E(): 4e-26%3B 48.667%25 identity in 150 aa overlap. Contains hydrophobic%2C possible membrane-spanning regions gene gene7351 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7288 SCO7289 SCO7289 SC5H1.03 SC5H1.03 8094134 8094562 - regulator SC5H1.03%2C possible regulator%2C len: 142 aa%3B similar to TR:P95753 (EMBL:D50051)%2C ssgA%2C Streptomyces griseus gene involved in regulation of sporulation and cell division (136 aa)%2C fasta scores%3B opt: 175 z-score: 240.4 E(): 4.6e-06%2C 32.5%25 identity in 120 aa overlap. Similar to SC5F2A.05c (EMBL:AL049587) S.coelicolor possible regulator (138 aa) (33.8%25 identity in 145 aa overlap) gene gene7352 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7289 SCO7290 SCO7290 SC5H1.02 SC5H1.02 8094656 8095633 - dehydrogenase SC5H1.02%2C probable dehydrogenase%2C len: 325 aa%3B similar to many e.g. TR:O68447 (EMBL:AF041061)%2C fgd%2C Mycobacterium smegmatis F420-dependent glucose-6-phosphate dehydrogenase (336 aa)%2C fasta scores%3B opt: 461 z-score: 553.9 E(): 1.6e-23%2C 33.4%25 identity in 335 aa overlap. N-terminus similar to N-terminus of SCD78.18c (EMBL:AL034355) S.coelicolor hypothetical protein (320 aa) (31.7%25 identity in 183 aa overlap) gene gene7353 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7290 SCO7291 SCO7291 SC5F8.01c SC5F8.01c 8095690 8097306 - Ser/Thr protein kinase SC5H1.01%2C probable Ser/Thr protein kinase%2C partial CDS%2C len: >459 aa%3B similar to many eukaryotic-type e.g. SW:AFSK_STRCO (EMBL:D15062)%2C afsK%2C Streptomyces coelicolor eukaryotic-type protein kinase involved in secondary metabolism (799 aa)%2C fasta scores%3B opt: 261 z-score: 221.3 E(): 5.3e-05%2C 30.3%25 identity in 498 aa overlap and SW:KRCB_RAT (EMBL:D30041) Rattus norvegicus RAC-beta Ser/Thr kinase (481 aa) (31.4%25 identity in 169 aa overlap). A hydrophobic region is present%2C so it is possible that the protein spans a membrane. Contains Pfam match to entry PF00069 pkinase%2C Eukaryotic protein kinase domain%2C score 30.80%2C E-value 1.9e-07~SC5F8.01c%2C possible Ser/Thr protein kinase%2C partials CDS%2C len:> 114 aa. Similar to many proposed Streptomyces coelicolor Ser/Thr protein kinases e.g. TR:CAB82014(EMBL:AL161755) SCD63.07 (717 aa)%2C fasta scores opt: 172 z-score: 222.0 E(): 6.8e-05 33.0%25 identity in 103 aa overlap. Overlaps and extends into CDS SC5H1.01 on the adjoining cosmid. gene gene7354 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7291 SCO7292 SCO7292 SC5F8.02c SC5F8.02c 8097454 8098413 - threonine dehydratase SC5F8.02c%2C possible threonine dehydratase%2C len: 319 aa. Similar to many including: Escherichia coli SW:THD2_ECOLI(EMBL:M21312) threonine dehydratase catabolic (EC 4.2.1.16) TdcB (329 aa)%2C fasta scores opt: 609 z-score: 676.6 E(): 3.2e-30 39.4%25 identity in 312 aa overlap. Contains a Prosite hit to Ser/Thr dehydratases pyridoxal-phosphate attachment site and a Pfam match to entry PF00291 S_T_dehydratase%2C Pyridoxal-phosphate dependent enzyme. gene gene7355 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7292 SCO7293 SCO7293 SC5F8.03c SC5F8.03c 8098439 8099116 - hypothetical protein SC5F8.03c%2C hypothetical protein%2C len: 225 aa. Similar to several proteins of undefined function including: Deinococcus radiodurans TR:Q9RWP1 (EMBL:AE001920) conserved hypothetical protein (254 aa)%2C fasta scores opt: 467 z-score: 555.6 E(): 1.8e-23 36.6%25 identity in 205 aa overlap and Streptomyces coelicolor TR:CAB70638 (EMBL:AL137242) SC8F4.12C (239 aa)%2C fasta scores opt: 397 z-score: 474.2 E(): 6.1e-19 36.1%25 identity in 183 aa overlap gene gene7356 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7293 SCO7294 SCO7294 SC5F8.04c SC5F8.04c 8099128 8100432 - hypothetical protein SC5F8.04c%2C hypothetical protein%2C len: 434 aa. Similar to Streptomyces coelicolor TR:Q9X9W9 (EMBL:AL096743) transport associated protein%2C SCI7.21 (399 aa)%2C fasta scores opt: 428 z-score: 449.2 E(): 1.5e-17 38.3%25 identity in 209 aa overlap gene gene7357 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7294 SCO7295 SCO7295 SC5F8.05c SC5F8.05c 8100524 8103490 - LuxR family transcriptional regulator SC5F8.05c%2C possible LuxR-family regulator%2C len: 988 aa. Similar to several other regulators from Streptomyces coelicolor including: TR:Q9XAN4 (EMBL:AL079355) SC4C6.06 (893 aa)%2C fasta scores opt: 305 z-score: 328.7 E(): 7.7e-11 26.4%25 identity in 910 aa overlap and TR:Q9Z573 (EMBL:AL035569) SC8D9.18 (1091 aa)%2C fasta scores opt: 857 z-score: 926.1 E(): 0 36.5%25 identity in 1077 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) Pfam match to entry PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family. gene gene7358 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7295 SCO7296 SCO7296 SC5F8.06c SC5F8.06c 8103557 8103910 - hypothetical protein SC5F8.06c%2C unknown%2C len: 117 aa. Similar in parts to Streptomyces coelicolor TR:Q9R3I9(EMBL:AJ249450) hypothetical 9.6 kd protein (86 aa)%2C fasta scores opt: 295 z-score: 318.5 E(): 2.8e-10 51.4%25 identity in 72 aa overlap. gene gene7359 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7296 SCO7297 SCO7297 SC5F8.07c SC5F8.07c 8103907 8105400 - two-component sensor histidine kinase SC5F8.07c%2C possible two-component sensor histidine kinase%2C len: 492 aa. The C-terminus of this protein is similar to many sensor histidine protein kinases e.g. Salmonella typhimurium SW:NTRB_SALTY (EMBL:X85104) nitrogen regulation protein NR(II) (EC 2.7.3.-) (349 aa)%2C fasta scores opt: 313 z-score: 363.5 E(): 8.9e-13 27.9%25 identity in 297 aa overlap. Contains a Pfam match to entry PF00512 signal%2C Histidine kinase. Also contains a 4xTPD repeat in the C-terminus. gene gene7360 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7297 SCO7298 SCO7298 SC5F8.08c SC5F8.08c 8105397 8107073 - thioredoxin reductase SC5F8.08c%2C possible thioredoxin reductase%2C len: 558 aa. The C-terminus of this protein is highly similar to many thioredoxin reductases including: Streptomyces clavuligerus SW:TRXB_STRCL(EMBL:Z21946) thioredoxin reductase (EC 1.6.4.5) (321 aa)%2C fasta scores opt: 494 z-score: 519.8 E(): 1.7e-21 32.8%25 identity in 332 aa overlap. The N-terminus is similar to the receiver domains of many response regulators e.g. Alcaligenes eutrophus SW:HOXA_ALCEU(EMBL:M64593) hydrogenase transcriptional regulatory protein%2C HoxA (482 aa) (32%25 identity over a 117 aa overlap). Contains Pfam matches to entries PF00070 pyr_redox%2C Pyridine nucleotide-disulphide oxidoreductase and PF00072 response_reg%2C Response regulator receiver domain. gene gene7361 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7298 SCO7299 SCO7299 SC5F8.09 SC5F8.09 8107218 8108156 + stress-inducible protein SC5F8.09%2C possible stress-inducible protein%2C len:312 aa. Highly similar to many proteins of undefined function e.g. Streptomyces coelicolor TR:Q9RIY4(EMBL:AL109962) hypothetical 34.7 kd protein%2C SCJ1.30C (328 aa)%2C fasta scores opt: 604 z-score: 654.8 E(): 5.3e-29 41.8%25 identity in 328 aa overlap. Contains 2xPfam match to entry PF00582 Usp%2C Universal stress protein family. gene gene7362 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7299 SCO7300 SCO7300 SC5F8.10c SC5F8.10c 8108173 8109405 - hypothetical protein SC5F8.10c%2C unknown%2C len: 410 aa. gene gene7363 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7300 SCO7301 SCO7301 SC5F8.11c SC5F8.11c 8109415 8110161 - hypothetical protein SC5F8.11c%2C unknown%2C len: 248 aa. Highly similar to many beta-lactamases including: Mycobacterium avium TR:Q9XC16(EMBL:AF152394) beta-lactamase%2C BllP (247 aa)%2C fasta scores opt: 789 z-score: 885.8 E():0 48.1%25 identity in 241 aa overlap. Contains a Pfam match to entry PF00753 lactamase_B%2C Metallo-beta-lactamase superfamily. gene gene7364 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7301 SCO7302 SCO7302 SC5F8.12c SC5F8.12c 8110240 8110872 - hypothetical protein SC5F8.12c%2C hypothetical protein%2C len: 210 aa%3B similar to TR:AAK45279 (EMBL:AE006986) Mycobacterium tuberculosis CDC1551 hypothetical protein MT1029%2C 205 aa%3B fasta scores: opt: 784 Z-score: 926.8 E(): 5.5e-44%3B 56.796%25 identity in 206 aa overlap gene gene7365 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7302 SCO7303 SCO7303 SC5F8.13 SC5F8.13 8111066 8111647 + TetR family transcriptional regulator SC5F8.13%2C possible TetR-family regulator%2C len: 193 aa. Weakly similar to Pseudomonas putida TR:O33453(EMBL:U24215) regulator of the p-cymene and p-Cumate catabolic operons%2C CymR (203 aa)%2C fasta scores opt: 174 z-score: 221.1 E(): 7.6e-05 28.2%25 identity in 174 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene7366 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7303 SCO7304 SCO7304 SC5F8.14 SC5F8.14 8111687 8113360 + FAD-binding dehydrogenase proposed role in polysaccahride synthesis gene gene7367 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7304 SCO7305 SCO7305 SC5F8.15c SC5F8.15c 8113394 8113747 - hypothetical protein SC5F8.15c%2C unknown%2C len: 117 aa. Highly similar to several proteins of undefined function including: Mycobacterium tuberculosis SW:YD08_MYCTU(EMBL:Z83866) (118 aa)%2C fasta scores opt: 334 z-score: 429.2 E(): 1.9e-16 49.1%25 identity in 112 aa overlap and Escherichia coli SW:YEAO_ECOLI(EMBL:AE000274) (122 aa)%2C fasta scores opt: 296 z-score: 382.1 E(): 8.2e-14 42.7%25 identity in 110 aa overlap. gene gene7368 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7305 SCO7306 SCO7306 SC5F8.16c SC5F8.16c 8113809 8114060 - regulatory protein SC5F8.16c%2C regulatory protein%2C len: 83 aa. Highly similar to several e.g. Streptomyces coelicolor TR:CAB88918(EMBL:AL353862) regulatory protein%2C WhiB%2C essential for sporulation (87 aa)%2C fasta scores opt: 214 z-score: 299.5 E(): 3.3e-09 45.1%25 identity in 71 aa overlap. gene gene7369 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7306 SCO7307 SCO7307 SC5F8.17c SC5F8.17c 8114185 8115087 - chromosome replication initiation inhibitor protein specific inhibitor of chromosomal initiation of replication in vitro%3B binds the three 13-mers in the origin (oriC) to block initiation of replication%3B also controls genes involved in arginine transport gene gene7370 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7307 SCO7308 SCO7308 SC5F8.18 SC5F8.18 8115165 8115779 + membrane transport protein SC5F8.18%2C possible membrane transport protein%2C len: 204 aa. Highly similar to many including: Corynebacterium glutamicum SW:LYSE_CORGL(EMBL:X96471) lysine exporter protein%2C LysE (236 aa)%2C fasta scores opt: 201 z-score: 247.8 E(): 2.5e-06 34.8%25 identity in 224 aa overlap and to many hypothetical proteins e.g. Mycobacterium tuberculosis SW:YW33_MYCTU(EMBL:Z74025) (199 aa)%2C fasta scores opt: 668 z-score: 801.1 E(): 0 54.0%25 identity in 200 aa overlap. Contains a Pfam match to entry PF01810 LysE%2C LysE type translocator and multiple possible membrane spanning hydrophobic domains. gene gene7371 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7308 SCO7309 SCO7309 SC5F8.19 SC5F8.19 8115853 8117187 + membrane transport protein SC5F8.19%2C possible membrane transport protein%2C len: 444 aa. Similar to many including: Streptococcus pyogenes TR:P95827(EMBL:U70055) macrolide-efflux protein%2C MefA (405 aa)%2C fasta scores opt: 339 z-score: 368.8 E(): 4.5e-13 23.1%25 identity in 399 aa overlap and Streptomyces coelicolor TR:Q9RKR4(EMBL:AL133220) integral membrane protein%2C SCC75A.10 (431 aa)%2C fasta scores opt: 895 z-score: 962.2 E(): 0 38.2%25 identity in 408 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7372 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7309 SCO7310 SCO7310 SC5F8.20c SC5F8.20c 8117195 8117650 - regulatory protein SC5F8.20c%2C possible regulatory protein%2C len: 151 aa. Similar in parts to Pseudomonas sp.TR:O52578 (EMBL:AF040987) FNR-like regulator%2C NnrR (223 aa)%2C fasta scores opt: 161 z-score: 223.3 E(): 5.7e-05 25.2%25 identity in 131 aa overlap and Streptomyces coelicolor TR:Q9RIZ7 (EMBL:AL109962) possible regulator protein%2C SCJ1.17 (190 aa)%2C fasta scores opt: 500 z-score: 675.2 E(): 3.8e-30 49.7%25 identity in 151 aa overlap. Contains a Pfam match to entry PF00027 cNMP_binding%2C Cyclic nucleotide-binding domain. gene gene7373 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7310 SCO7311 SCO7311 SC5F8.21c SC5F8.21c 8118005 8119483 - amino acid decarboxylase SC5F8.21c%2C probable amino acid decarboxylase%2C len: 492 aa. Similar to many e.g. Bacillus subtilis SW:DCLY_BACSU (EMBL:X58433) lysine decarboxylase (EC 4.1.1.18) (490 aa)%2C fasta scores: opt: 1108 z-score: 1197.8 E():0 35.6%25 identity in 494 aa overlap. Contains a Pfam match to entry PF01276 OKR_DC_1%2C Orn/Lys/Arg decarboxylase. gene gene7374 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7311 SCO7312 SCO7312 SC5F8.22c SC5F8.22c 8119513 8119746 - hypothetical protein SC5F8.22c%2C unknown%2C len: 77 aa. gene gene7375 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7312 SCO7313 SCO7313 SC5F8.23 SC5F8.23 8119902 8120348 + hypothetical protein SC5F8.23%2C unknown%2C len: 148 aa. Weakly similar to several regulatory proteins e.g. Streptomyces coelicolor A3(2) TR:Q9RIS7(EMBL:AJ249581) regulator of sig15 (170 aa)%2C fasta scores opt: 144 z-score: 184.4 E(): 0.0084 36.1%25 identity in 133 aa overlap and Streptomyces coelicolor TR:Q9RD41(EMBL:AL133422) SCM1.01C (147 aa)%2C fasta scores opt: 225 z-score: 281.4 E(): 3.3e-08 36.6%25 identity in 131 aa overlap. gene gene7376 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7313 SCO7314 SCO7314 SC5F8.24 SC5F8.24 8120541 8121440 + RNA polymerase sigma factor SC5F8.24%2C probable RNA polymerase sigma factor%2C len: 299 aa. Highly similar to many e.g. Streptomyces coelicolor SW:RPOF_STRCO (EMBL:L11648) RNA polymerase sigma-F factor%2C SigF (287 aa)%2C fasta scores opt: 687 z-score: 772.9 E(): 0 43.6%25 identity in 275 aa overlap. Contains a Pfam match to entry PF00140 sigma70%2C Sigma-70 factor and a helix-turn-helix motif situated between residues 242..263 (+6.95 SD). gene gene7377 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7314 SCO7315 SCO7315 SC5F8.25 SC5F8.25 8121460 8121699 + hypothetical protein SC5F8.25%2C unknown%2C len: 79 aa. Similar to Streptomyces coelicolor TR:O54206(EMBL:AJ001206) hypothetical protein%2C PepA (90 aa)%2C fasta scores opt: 106 z-score: 152.7 E():0.49 32.2%25 identity in 87 aa overlap. gene gene7378 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7315 SCO7316 SCO7316 SC5F8.26 SC5F8.26 8121760 8122602 + hypothetical protein SC5F8.26%2C possible integral membrane protein%2C len: 280 aa. Similar to Bacillus subtilis SW:YXXB_BACSU(EMBL:D45912) hypothetical 31.8 kd protein (289 aa)%2C fasta scores opt: 476 z-score: 539.7 E(): 1.4e-22 31.0%25 identity in 245 aa overlap. Contains multiple possible membrane spanning hydrophobic domains gene gene7379 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7316 SCO7317 SCO7317 SC5F8.27 SC5F8.27 8122631 8123065 + hypothetical protein SC5F8.27%2C unknown%2C len: 144 aa. gene gene7380 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7317 SCO7318 SCO7318 SC5F8.28c SC5F8.28c 8123089 8125347 - hypothetical protein SC5F8.28c%2C possible membrane protein%2C len: 752 aa%3B similar to TR:Q9AJZ2 (EMBL:AL512944) Streptomyces coelicolor integral membrane protein SC8D11.27c%2C 753 aa%3B fasta scores: opt: 773 Z-score: 794.0 E(): 1.4e-36%3B 37.281%25 identity in 743 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Note the predicted product of this CDS is rich in the amino acid Leucine gene gene7381 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7318 SCO7319 SCO7319 SC5F8.29c SC5F8.29c 8125470 8126915 - oxidoreductase SC5F8.29c%2C possible oxidoreductase%2C len: 481 aa. Similar to many dehydrogenases including: Escherichia coli SW:DHNA_ECOLI(EMBL:V00306) NADH dehydrogenase (EC 1.6.99.3) (433 aa)%2C fasta scores opt: 438 z-score: 509.8 E(): 6.4e-21 26.3%25 identity in 384 aa overlap and Streptomyces coelicolor TR:Q9ZC17(EMBL:AL033505) dehydrogenase%2C SC1E6.05 (629 aa)%2C fasta scores opt: 1148 z-score: 1329.8 E(): 0 44.3%25 identity in 420 aa overlap. Contains a Pfam match to entry PF00070 pyr_redox%2C Pyridine nucleotide-disulphide oxidoreductase. Note codon 27 may offer an alternative translational start site. gene gene7382 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7319 SCO7320 SCO7320 SC5F8.30c SC5F8.30c 8127055 8128797 - hypothetical protein SC5F8.30c%2C unknown%2C len: 580 aa. Similar in parts to many Streptomyces coelicolor proteins of undefined function including: TR:Q9RJE1(EMBL:AL133171) regulatory protein%2C SCF81.10C (828 aa)%2C fasta scores opt: 676 z-score: 710.0 E(): 4.5e-32 34.7%25 identity in 426 aa overlap and TR:Q9X8W1(EMBL:AL078610%3B) hypothetical 66.2 kd protein%2C SCH35.45C (634 aa)%2C fasta scores opt: 633 z-score: 666.6 E(): 1.2e-29 33.4%25 identity in 539 aa overlap. gene gene7383 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7320 SCO7321 SCO7321 SC5F8.31c SC5F8.31c 8128794 8129858 - hypothetical protein SC5F8.31c%2C unknown%2C len: 354 aa. Similar to Deinococcus radiodurans TR:Q9RZT6(EMBL:AE001826) hypothetical TorS-related protein (351 aa)%2C fasta scores opt: 393 z-score: 443.7 E(): 3e-17 34.7%25 identity in 354 aa overlap. gene gene7384 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7321 SCO7322 SCO7322 SC4G10.01c SC4G10.01c 8129858 8130298 - anti-sigma factor SC4G10.01c%2C possible anti-sigma factor%2C partial CDS%2C len: >57 aa. Highly similar to several including: Bacillus subtilis SW:RSBT_BACSU (EMBL:L35574) anti-sigma B factor controlling SigB the general stress sigma factor (133 aa)%2C fasta scores opt: 144 z-score: 235.0 E(): 1.3e-05 48.0%25 identity in 50 aa overlap and Deinococcus radiodurans TR:AAF12580(EMBL:AE001826) sigma-B regulator%2C RsbT (137 aa)%2C fasta scores opt: 201 z-score: 321.3 E(): 2e-10 63.2%25 identity in 57 aa overlap.~SC5F8.32c%2C possible anti-sigma factor%2C partial CDS%2C len: >129 aa. Highly similar to several anti-sigma factors including: Bacillus subtilis SW:RSBT_BACSU(EMBL:) anti-sigma B factor%2C RsbT (133 aa)%2C fasta scores opt: 452 z-score: 536.7 E(): 2e-22 57.6%25 identity in 118 aa overlap. Overlaps and extends into CDS SC4G10.01c on the adjoining cosmid. gene gene7385 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7322 SCO7323 SCO7323 SC4G10.02c SC4G10.02c 8130298 8130729 - anti-sigma factor antagonist SC4G10.02c%2C anti-sigma factor antagonist%2C len: 143 aa. Highly similar to many anti-anti sigma factors e.g. Bacillus subtilis SW:RSBS_BACSU (EMBL:L35574) anti-sigma factor antagonist%2C RsbS (121 aa)%2C fasta scores opt: 341 z-score: 417.5 E(): 8.5e-16 43.4%25 identity in 113 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA%2C SpoIIAA family. gene gene7386 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7323 SCO7324 SCO7324 SC4G10.03c SC4G10.03c 8130726 8131625 - regulatory protein SC4G10.03c%2C possible regulatory protein%2C len: 299 aa. Similar to Bacillus subtilis SW:RSBR_BACSU(EMBL:L35574) positive regulator of sigma-B activity%2C RsbR (274 aa)%2C fasta scores opt: 401 z-score: 450.7 E(): 1.2e-17 27.6%25 identity in 279 aa overlap. gene gene7387 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7324 SCO7325 SCO7325 SC4G10.04c SC4G10.04c 8131786 8132178 - anti-sigma factor antagonist SC4G10.04c%2C anti-sigma factor antagonist%2C len: 130 aa. Similar to many including: Bacillus licheniformis SW:SP21_BACLI (EMBL:M25260) anti-sigma F factor antagonist (stage II sporulation protein AA) (117 aa)%2C fasta scores opt: 187 z-score: 252.1 E(): 1.4e-06 28.4%25 identity in 109 aa overlap and Streptomyces coelicolor SW:RSBV_STRCO (EMBL:AF134889) anti-sigma factor antagonist%2C BldG (113 aa)%2C fasta scores opt: 196 z-score: 263.7 E(): 3.2e-07 26.5%25 identity in 102 aa overlap. Contains a Pfam match to entry PF01740 SpoIIAA%2C SpoIIAA family. gene gene7388 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7325 SCO7326 SCO7326 SC4G10.05c SC4G10.05c 8132296 8134770 - hypothetical protein SC4G10.05c%2C unknown%2C len: 824 aa. Similar to several Streptomyces coelicolor proteins of undefined function e.g. TR:CAB61192(EMBL:AL132973) SCF91.35 (884 aa)%2C fasta scores opt: 385 z-score: 407.5 E(): 3.1e-15 26.1%25 identity in 885 aa overlap gene gene7389 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7326 SCO7327 SCO7327 SC4G10.06c SC4G10.06c 8134767 8138762 - two-component system sensory histidine kinase SC4G10.06c%2C possible two-component system sensory histidine kinase%2C len: 1331 aa. Highly similar in parts to many including: Pseudomonas syringae (pv. syringae) SW:LEMA_PSESY(EMBL:M80477) sensor protein%2C LemA (EC 2.7.3.-)%2C (907 aa)%2C fasta scores opt: 641 z-score: 627.6 E(): 1.7e-27 31.2%25 identity in 872 aa overlap and Streptomyces coelicolor TR:O86808(EMBL:AL031031) sensory histidine kinase%2C SC7C7.03 (1829 aa)%2C fasta scores opt: 2600 z-score: 2540.8 E():0 59.1%25 identity in 1346 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain%2C PF00512 signal%2C Histidine kinase and Pfam match to entry PF01590 GAF%2C GAF domain. Contains a 5x degenerate repeat region between residues 55..493 and a possible coiled-coil between residues 701..756. gene gene7390 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7327 SCO7328 SCO7328 SC4G10.07c SC4G10.07c 8139033 8139467 - regulatory protein SC4G10.07c%2C possible regulatory protein%2C len: 144 aa. Highly similar to Streptomyces fradiae TR:Q9Z9I5 (EMBL:AB024056) beta-lactamase regulator protein (139 aa)%2C fasta scores opt: 530 z-score: 661.7 E(): 2.2e-29 61.5%25 identity in 122 aa overlap and Streptomyces coelicolor TR:Q9X7S3 (EMBL:AL049863) regulator protein%2C SC5H1.15C (151 aa)%2C fasta scores opt: 178 z-score: 231.0 E(): 2.1e-05 30.8%25 identity in 130 aa overlap. gene gene7391 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7328 SCO7329 SCO7329 SC4G10.08c SC4G10.08c 8139603 8141513 - long-chain-fatty-acid-CoA ligase SC4G10.08c%2C possible long-chain-fatty-acid-CoA ligase%2C len: 636 aa. Highly similar to many proposed long-chain-fatty-acid-CoA ligases including: Homo sapiens SW:LCFB_HUMAN(EMBL:D10040) long-chain-fatty-acid--CoA ligase 2 (EC 6.2.1.3) (698 aa)%2C fasta scores opt: 447 z-score: 498.5 E(): 2.6e-20 26.3%25 identity in 616 aa overlap and several from Streptomyces coelicolor e.g. TR:Q9ZBW6(EMBL:AL034443) SC4B5.02C (608 aa)%2C fasta scores opt: 1881 z-score: 2101.5 E(): 0 47.0%25 identity in 611 aa overlap. Contains a Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme. gene gene7392 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7329 SCO7330 SCO7330 SC4G10.09 SC4G10.09 8141668 8141904 + hypothetical protein SC4G10.09%2C possible membrane protein%2C len: 78 aa. Contains a possible membrane spanning hydrophobic domain. gene gene7393 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7330 SCO7331 SCO7331 SC4G10.10c SC4G10.10c 8141930 8143021 - carboxylate-amine ligase ATP-dependent carboxylate-amine ligase gene gene7394 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7331 SCO7332 SCO7332 glgBII glgBII 8143094 8145319 - 1%2C4-alpha-glucan-branching protein catalyzes the transfer of a segment of a 1%2C4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain gene gene7395 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7332 SCO7333 SCO7333 pep2B pep2B 8145323 8146684 - hypothetical protein gene gene7396 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7333 SCO7334 SCO7334 SC4G10.13c SC4G10.13c 8146713 8148431 - trehalose synthase gene gene7397 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7334 SCO7335 SCO7335 pep1B pep1B 8148428 8150437 - alpha-amylase SC4G10.14c%2C pep1B%2C possible alpha-amylase%2C len: 669 aa. Previously sequenced region: Streptomyces coelicolor TR:O70012(EMBL:AJ001206) alpha amylase family protein%2C Pep1 (669 aa). Highly similar to Streptomyces coelicolor TR:CAB72419(EMBL:AL138978) alpha-amylase%2C Pep1A or SC6A11.19C (675 aa)%2C fasta scores opt: 4023 z-score: 4488.3 E(): 0 88.4%25 identity in 658 aa overlap. Contains a Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase. gene gene7398 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7335 SCO7336 SCO7336 pepA pepA 8150499 8150771 - hypothetical protein SC4G10.15c%2C pepA%2C unknown%2C len: 90 aa. Previously sequenced region: Streptomyces coelicolor TR:O54206(EMBL:AJ001206) hypothetical protein%2C PepA (90 aa). gene gene7399 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7336 SCO7337 SCO7337 pepA2 pepA2 8151064 8151579 + hypothetical protein SC4G10.16%2C pepA2%2C unknown%2C len: 171 aa. Previously sequenced region: Streptomyces coelicolor TR:O54205(EMBL:AJ001206) hypothetical protein%2C PepA2 (171 aa). gene gene7400 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7337 SCO7338 SCO7338 glgX glgX 8151576 8153723 + glycogen debranching protein SC4G10.17%2C glgX%2C possible glycogen debranching enzyme%2C len: 715 aa. Previously sequenced region: Streptomyces coelicolor TR:Q9X947(EMBL:AJ001206) (715 aa). Highly similar to Escherichia coli SW:GLGX_ECOLI(EMBL:J01616) glycogen operon protein%2C GlgX (EC 3.2.1.-) (657 aa)%2C fasta scores opt: 1948 z-score: 2333.6 E():0 47.5%25 identity in 673 aa overlap and Streptomyces coelicolor TR:CAB76010(EMBL:AL157916) glycosyl hydrolase%2C GlgX2 or SC3D11.13c (782 aa)%2C fasta scores opt: 2622 z-score: 3141.4 E(): 0 58.5%25 identity in 725 aa overlap. Contains a Pfam match to entry PF00128 alpha-amylase%2C Alpha amylase. gene gene7401 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7338 SCO7339 SCO7339 SC4G10.18c SC4G10.18c 8153726 8154562 - hypothetical protein SC410.18c%2C unknown%2C len: 278 aa. Partially sequenced previously: Streptomyces coelicolor TR:Q9X946(EMBL:AJ001206) hypothetical 17.2 kd protein (>161 aa). Also highly similar to Streptomyces griseus TR:P95754(EMBL:D89734) SgaA protein%2C a suppressor of growth disturbance in the presence of high osmolarity and high concentrations of A-factor (264 aa)%2C fasta scores opt: 807 z-score: 948.0 E():0 52.0%25 identity in 250 aa overlap. gene gene7402 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7339 SCO7340 SCO7340 SC4G10.19 SC4G10.19 8154652 8155017 + hypothetical protein SC410.19%2C unknown%2C len: 121 aa. Similar to Streptomyces coelicolor TR:Q9S1U3(EMBL:AL109950) hypothetical 11.6 kd protein%2C SCJ4.30 (107 aa)%2C fasta scores opt: 285 z-score: 344.7 E(): 9.8e-12 54.3%25 identity in 92 aa overlap. gene gene7403 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7340 SCO7341 SCO7341 SC4G10.20c SC4G10.20c 8154965 8155756 - RNA polymerase secondary sigma factor SC4G10.20c%2C sigG%2C possible RNA polymerase secondary sigma factor%2C len: 263 aa. Previously sequenced region: Streptomyces coelicolor TR:O52313 (EMBL:AF036131) (263 aa). Highly similar to Streptomyces coelicolor SW:RPOF_STRCO (EMBL:L11648) RNA polymerase sigma-F factor (287 aa)%2C fasta scores opt: 682 z-score: 820.1 E(): 0 49.2%25 identity in 240 aa overlap. Contains a Prosite hit to PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 and a Pfam match to entry PF00140 sigma70%2C Sigma-70 factor. A possible helix-turn-helix motif situated between residues 227..248 (+6.87 SD). gene gene7404 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7341 SCO7342 SCO7342 SC4G10.21 SC4G10.21 8156060 8156584 + hypothetical protein SC410.21%2C unknown%2C len: 174 aa. Previously sequenced region: Streptomyces coelicolor TR:O52312(EMBL:AF036131) (174 aa). gene gene7405 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7342 SCO7343 SCO7343 hemC hemC 8156604 8157545 - porphobilinogen deaminase SC4G10.22c%2C hemC%2C porphobilinogen deaminase (EC 4.3.1.8). len: 313 aa. Highly similar to many e.g. Escherichia coli SW:HEM3_ECOLI(EMBL:X04242) porphobilinogen deaminase (EC 4.3.1.8) (313 aa)%2C fasta scores opt: 710 z-score: 839.8 E(): 0 42.2%25 identity in 303 aa overlap. Contains a Pfam match to entry PF01379 Porphobil_deam%2C Porphobilinogen deaminase. gene gene7406 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7343 SCO7344 SCO7344 SC4G10.23c SC4G10.23c 8157613 8158389 - hypothetical protein SC4G10.23c%2C possible hypothetical protein%2C len: 258 aa. Weakly similar to the Eukaryotic protein elicitor from Pythium aphanidermatum TR:Q9SPD4(EMBL:AF179598) 25 kda protein elicitor (234 aa)%2C fasta scores opt: 279 z-score: 316.6 E(): 3.6e-10 31.0%25 identity in 242 aa overlap. Contains a possible N-terminal signal sequence gene gene7407 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7344 SCO7345 SCO7345 SC4G10.24c SC4G10.24c 8158531 8159511 - ATP-dependent DNA ligase SC4G10.24c%2C probable ATP-dependent DNA ligase%2C len: 326 aa. Similar in parts to many DNA ligases e.g. Pyrococcus horikoshii SW:DNLI_PYRHO(EMBL:AP000006) probable thermostable DNA ligase (EC 6.5.1.1) (559 aa)%2C fasta scores opt: 454 z-score: 506.0 E(): 1e-20 32.0%25 identity in 344 aa overlap. Contains a Prosite hit to PS00697 ATP-dependent DNA ligase AMP-binding site and a Pfam match to entry PF01068 DNA_ligase%2C DNA ligase. gene gene7408 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7345 SCO7346 SCO7346 SC4G10.25c SC4G10.25c 8159608 8161062 - membrane transport protein SC4G10.25c%2C possible membrane transport protein%2C len: 484 aa. Highly similar to several including: Streptomyces glaucescens SW:TCMA_STRGA(EMBL:M80674) tetracenomycin C resistance and export protein%2C TcmA (528 aa)%2C fasta scores opt: 538 z-score: 582.2 E(): 5.8e-25 27.8%25 identity in 475 aa overlap and Streptomyces coelicolor TR:CAB88188(EMBL:AL352972) transport protein (fragment)%2C SCC30.18 (348 aa)%2C fasta scores opt: 1368 z-score: 1475.7 E():0 60.0%25 identity in 340 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. gene gene7409 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7346 SCO7347 SCO7347 SC4G10.26. SC4G10.26. 8161299 8161964 + hypothetical protein SC9H11.01%2C unknown%2C partial CDS%2C len: >201 aa.~SC410.26%2C unknown%2C partial CDS%2C len: >55 aa. Overlaps and extends into CDS SC9H11.01 on the adjoining cosmid. gene gene7410 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7347 SCO7348 SCO7348 SC9H11.02c SC9H11.02c 8162202 8162315 - hypothetical protein SC9H11.02c%2C doubtful CDS%2C len: 37 aa. Highly similar to predicted sequences encoded within repeat unit 7 on this cosmid: SC9H11.03c (37 aa)%2C fasta scores opt: 244 z-score: 268.5 E(): 2e-09 91.9%25 identity in 37 aa and the C-terminal 37 aa of SC9H11.04c (398 aa)%2C fasta scores opt: 225 z-score: 234.8 E(): 1.5e-07 91.9%25 identity in 37 aa overlap overlap. gene gene7411 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7348 SCO7349 SCO7349 SC9H11.03c SC9H11.03c 8162393 8162506 - hypothetical protein SC9H11.03c%2C doubtful CDS%2C len: 37 aa. Highly similar to predicted sequences encoded within repeat unit 7 on this cosmid: SC9H11.02c (37 aa)%2C fasta scores opt: 244 z-score: 268.5 E(): 2e-09 91.9%25 identity in 37 aa and the C-terminal 37 aa of SC9H11.04c (398 aa)%2C fasta scores opt: 205 z-score: 222.0 E(): 7.9e-07 83.8%25 identity in 37 aa overlap. gene gene7412 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7349 SCO7350 SCO7350 SC9H11.04c SC9H11.04c 8162598 8163794 - membrane efflux protein SC9H11.04c%2C possible membrane efflux protein%2C len: 398 aa. Similar to many membrane efflux proteins including: Streptomyces lividans SW:CMLR_STRLI(EMBL:X59968) chloramphenicol resistance protein%2C CmlR (392 aa)%2C fasta scores opt: 227 z-score: 239.8 E(): 6.8e-06 27.7%25 identity in 411 aa overlap and Escherichia coli SW:FSR_ECOLI(EMBL:D73370) fosmidomycin resistance protein%2C FsR (406 aa)%2C fasta scores opt: 506 z-score: 524.2 E(): 9.8e-22 28.4%25 identity in 373 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Note that the C-terminal 37 aa of this protein are highly similar to CDS SC9H11.02c and SC9H11.03c. gene gene7413 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7350 SCO7351 SCO7351 SC9H11.05 SC9H11.05 8163849 8164718 + AraC family transcription regulator SC9H11.05%2C possible AraC-family transcriptional regulator%2C len: 289 aa. Similar to several including: Streptomyces coelicolor TR:O69819(EMBL:AL023496) transcriptional regulator%2C SC1A6.14 (256 aa)%2C fasta scores opt: 397 z-score: 464.2 E(): 2.2e-18 33.5%25 identity in 254 aa overlap and Escherichia coli SW:YEAM_ECOLI(EMBL:AE000274) hypothetical transcriptional regulator (273 aa)%2C fasta scores opt: 438 z-score: 510.8 E(): 5.4e-21 33.2%25 identity in 232 aa overlap. Contains a Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family with the helix-turn-helix motif situated between residues 194..215 (+4.88 SD). Contains a TTA /leucine codon which is a possible target for bldA regulation. gene gene7414 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7351 SCO7352 SCO7352 SC9H11.06 SC9H11.06 8164751 8165131 + hypothetical protein SC9H11.06%2C possible membrane protein%2C len: 126 aa. Similar to several proteins of undefined function from Deinococcus radiodurans e.g. TR:AAF11579(EMBL:AE002039) hypothetical 13.2 kd protein (120 aa)%2C fasta scores opt: 304 z-score: 370.4 E(): 3.6e-13 48.2%25 identity in 112 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7415 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7352 SCO7353 SCO7353 SC9H11.07 SC9H11.07 8165128 8165595 + hypothetical protein SC9H11.07%2C unknown%2C len: 155 aa. Highly similar to many bacterioferritin comigratory proteins e.g. Mycobacterium tuberculosis TR:O53911(EMBL:AL02200) bacterioferritin comigratory protein%2C BcpB (154 aa)%2C fasta scores opt: 618 z-score: 761.9 E():0 63.8%25 identity in 149 aa overlap. Contains a Pfam match to entry PF00578 AhpC-TSA%2C AhpC/TSA family gene gene7416 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7353 SCO7354 SCO7354 SC9H11.08 SC9H11.08 8165621 8168029 + hypothetical protein SC9H11.08%2C unknown%2C len: 802 aa. Similar to many proteins of undefined function e.g. Streptomyces coelicolor TR:CAB61537(EMBL:AL133171) hypothetical 89.7 kd protein%2C SCF81.26 (835 aa)%2C fasta scores opt: 2446 z-score: 2641.1 E(): 0 53.0%25 identity in 800 aa overlap. Contains Pfam matches to 2xentry PF00989 PAS%2C PAS domain. gene gene7417 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7354 SCO7355 SCO7355 SC9H11.09c SC9H11.09c 8168062 8168703 - hypothetical protein SC9H11.09c%2C unknown%2C len: 213 aa%3B similar to the N-terminal region of many ATP-dependent DNA ligases%2C e.g. TR:Q98J69 (EMBL:AP002998) Rhizobium loti (Mesorhizobium loti) probable ATP-dependent DNA ligase MLL2077%2C 833 aa%3B fasta scores:opt: 539 Z-score: 543.3 E(): 1.3e-22%3B 53.216%25 identity in 171 aa overlap gene gene7418 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7355 SCO7356 SCO7356 SC9H11.10c SC9H11.10c 8168760 8169590 - oxidoreductase SC9H11.10c%2C oxidoreductase%2C len: 276 aa. Highly similar to many including: Corynebacterium sp. SW:2DKG_CORSP(EMBL:M21193) 2%2C5-diketo-d-gluconic acid reductase (EC 1.1.1.-) (277 aa)%2C fasta scores opt: 1006 z-score: 1188.8 E(): 0 52.9%25 identity in 274 aa overlap and Streptomyces coelicolor TR:Q9ZBW7(EMBL:AL034443%3B) oxidoreductase%2C SC4B5.01C (277 aa)%2C fasta scores opt: 1018 z-score: 1202.9 E():0 56.3%25 identity in 268 aa overlap. Contains Prosite hits to PS00063 Aldo/keto reductase family active site signature%2C PS00062 Aldo/keto reductase family signature 2 and PS00798 Aldo/keto reductase family signature 1. Also contains a Pfam match to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family. gene gene7419 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7356 SCO7357 SCO7357 SC9H11.11 SC9H11.11 8169703 8170689 + dioxygenase SC9H11.11%2C probable dioxygenase%2C len: 328 aa. Highly similar to many including: Escherichia coli SW:TAUD_ECOLI(EMBL:D85613) alpha-ketoglutarate-dependent taurine dioxygenase (EC 1.14.-.-) (282 aa)%2C fasta scores opt: 462 z-score: 559.5 E(): 1.1e-23 35.0%25 identity in 294 aa overlap and Mycobacterium tuberculosis SW:YY06_MYCTU(EMBL:Z77165) dioxygenase RV3406 (EC 1.-.-.-) (295 aa)%2C fasta scores opt: 523 z-score: 632.3 E(): 9.3e-28 41.6%25 identity in 308 aa overlap. gene gene7420 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7357 SCO7358 SCO7358 SC9H11.12c. SC9H11.12c. 8170720 8172222 - hypothetical protein SC9H11.12c%2C unknown%2C len: 500 aa. gene gene7421 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7358 SCO7359 SCO7359 SC9H11.13c SC9H11.13c 8172314 8173069 - hydrolase SC9H11.13c%2C possible hydrolase%2C len: 251 aa. Weakly similar to several members of the Dienelactone hydrolase family e.g. Pseudomonas putida SW:CLCD_PSEPU(EMBL:M16964) carboxymethylenebutenolidase (EC 3.1.1.45) (246 aa)%2C fasta scores opt: 265 z-score: 312.9 E(): 5.7e-10 27.1%25 identity in 255 aa overlap and Mycobacterium tuberculosis TR:O33307(EMBL:AL008967) hypothetical 26.2 kd protein (245 aa)%2C fasta scores opt: 630 z-score: 731.0 E(): 0 43.1%25 identity in 246 aa overlap. Contains a Pfam match to entry PF01738 DLH%2C Dienelactone hydrolase family. gene gene7422 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7359 SCO7360 SCO7360 SC9H11.14c SC9H11.14c 8173119 8173721 - hypothetical protein SC9H11.14c%2C unknown%2C len: 200 aa. Previously sequenced: Streptomyces coelicolor TR:BAA82702(EMBL:AB017438) Orf5 (200 aa). Also similar to many other proteins of undefined function e.g. Neisseria meningitidis TR:AAF40874(EMBL:AE002400) conserved hypothetical protein (213 aa)%2C fasta scores opt: 821 z-score: 1024.7 E(): 0 56.8%25 identity in 199 aa overlap. Contains a Prosite hit to PS01147 SUA5/yciO/yrdC family signature and a Pfam match to entry PF01300 Sua5_yciO_yrdC%2C SUA5/yciO/yrdC family. Contains a helix-turn-helix motif situated between residues. gene gene7423 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7360 SCO7361 SCO7361 SC9H11.15. SC9H11.15. 8173887 8175416 + DNA-binding protein SC9H11.15%2C possible DNA-binding protein%2C len: 509 aa. Previously sequenced: Streptomyces coelicolor TR:BAA82701 (EMBL:AB017438) Orf4 (509). Contains a helix-turn-helix motif situated between residues 439..460 (+3.90 SD). gene gene7424 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7361 SCO7362 SCO7362 SC9H11.16c. SC9H11.16c. 8175571 8176611 - oxidoreductase SC9H11.16c%2C oxidoreductase%2C len: 346 aa. Previously sequenced: Streptomyces coelicolor TR:BAA82700EMBL:AB017438) Orf3 (346 aa). Also highly similar to Corynebacterium sp. ST-10 TR:Q9ZN85(EMBL:AB020760) phenylacetaldehyde reductase (385 aa)%2C fasta scores opt: 1382 z-score: 1438.5 E(): 0 65.2%25 identity in 316 aa overlap and many alcohol dehydrogenases e.g. from Sulfolobus solfataricus SW:ADH1_SULSO(EMBL:S51211) NAD-dependent alcohol dehydrogenase (EC 1.1.1.1) (347 aa)%2C fasta scores opt: 595 z-score: 624.4 E(): 2.5e-27 32.7%25 identity in 355 aa overlap. Contains a Prosite hit to PS00059 Zinc-containing alcohol dehydrogenases signature and a Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. gene gene7425 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7362 SCO7363 SCO7363 SC9H11.17c. SC9H11.17c. 8176680 8177471 - oxidoreductase SC9H11.17c%2C possible oxidoreductase%2C len: 263 aa. Almost identical to the previously sequenced: Streptomyces coelicolor TR:BAA82699EMBL:AB017438) Orf2 (263 aa). Also highly similar to Pseudomonas paucimobilis SW:LINC_PSEPA(EMBL:D14595) 2%2C5-dichloro-2%2C5-cyclohexadiene-1%2C4-diol dehydrogenase (EC 1.1.-.-) LinC (250 aa)%2C fasta scores opt: 580 z-score: 605.0 E(): 3.1e-26 42.5%25 identity in 252 aa overlap and Streptomyces coelicolor TR:O88068(EMBL:AL031541) dehydrogenase%2C SCI35.33C (260 aa)%2C fasta scores opt: 584 z-score: 608.8 E(): 1.9e-2 43.8%25 identity in 251 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. gene gene7426 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7363 SCO7364 SCO7364 SC9H11.18c SC9H11.18c 8177482 8178186 - TetR family transcriptional regulator SC9H11.18c%2C possible TetR-family transcriptional regulator%2C len: 221 aa. Previously sequenced: Streptomyces coelicolor TR:BAA82698 (EMBL:AB017438) Orf1 (187 aa). Differs with the previously published sequence in the C-terminus%2C possibly due to a frameshift in the original sequence. Similar to several e.g. Streptomyces glaucescens SW:TCMR_STRGA (EMBL:M80674) tetracenomycin C transcriptional repressor%2C TcmR (226 aa)%2C fasta scores opt: 338 z-score: 403.7 E(): 5e-15 37.3%25 identity in 217 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 54..75 (+4.96 SD). gene gene7427 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7364 SCO7365 SCO7365 SC9H11.19 SC9H11.19 8178292 8178615 + hypothetical protein SC9H11.19%2C unknown%2C len: 107 aa. gene gene7428 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7365 SCO7366 SCO7366 SC9H11.20 SC9H11.20 8178701 8179468 + hypothetical protein SC9H11.20%2C unknown%2C len: 225 aa. Similar to Streptomyces coelicolor TR:O86750(EMBL:AL031035) hypothetical 28.3 kd protein%2C SC6A9.18C (266 aa)%2C fasta scores opt: 304 z-score: 354.9 E(): 2.6e-12 32.8%25 identity in 253 aa overlap. gene gene7429 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7366 SCO7367 SCO7367 SC9H11.21c SC9H11.21c 8179502 8180842 - membrane efflux protein SC9H11.21c%2C probable membrane efflux protein%2C len: 446 aa. Similar to many proteins involved in arsenical resistance e.g. Staphylococcus xylosus SW:ARSB_STAXY(EMBL:M80565) arsenical pump membrane protein ArsB (429 aa)%2C fasta scores opt: 255 z-score: 240.6 E(): 6.1e-06 24.1%25 identity in 440 aa overlap and Mycobacterium tuberculosis TR:P96860(EMBL:Z92774) probable arsenical pump membrane protein (413 aa)%2C fasta scores opt: 730 z-score: 667.0 E(): 1.1e-29 53.7%25 identity in 445 aa overlap. Contains possible N-terminal region signal sequence peptide and multiple possible membrane spanning hydrophobic domains. gene gene7430 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7367 SCO7368 SCO7368 SC9H11.22 SC9H11.22 8181049 8181612 + hypothetical protein SC9H11.22%2C unknown%2C len: 187 aa. gene gene7431 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7368 SCO7369 SCO7369 SC9H11.23c SC9H11.23c 8181660 8182973 - transmembrane transport protein SC9H11.23c%2C possible transmembrane transport protein%2C len: 406 aa. Similar to many membrane transport proteins e.g. Zymomonas mobilis TR:Q9XBR9(EMBL:AF157493) transporter%2C DitE (431 aa)%2C fasta scores opt: 499 z-score: 512.6 E(): 4.3e-21 26.3%25 identity in 407 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7432 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7369 SCO7370 SCO7370 SC9H11.24 SC9H11.24 8183344 8184384 + NAD-dependent dehydratase SC9H11.24%2C NAD-dependent dehydratase%2C len: 346 aa. Similar to many members of the sugar epimerase/dehydratase family including: Streptomyces griseus SW:STRE_STRGR(EMBL:X62567) DTDP-glucose 4%2C6-dehydratase (EC 4.2.1.46) (328 aa)%2C fasta scores opt: 363 z-score: 378.8 E(): 1.2e-13 31.8%25 identity in 336 aa overlap and Streptomyces coelicolor TR:Q9ZBN0 (EMBL:AL034492) nucleotide-sugar dehydratase%2C SC6C5.15 (330 aa)%2C fasta scores opt: 977 z-score: 1003.9 E(): 0 52.6%25 identity in 321 aa overlap. Contains a Pfam match to entry PF01370 Epimerase%2C NAD dependent epimerase/dehydratase family. gene gene7433 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7370 SCO7371 SCO7371 SC9H11.25c SC9H11.25c 8184508 8185071 - hypothetical protein SC9H11.25c%2C unknown%2C len: 187 aa. Weakly similar to proteins of unknown function from: Schizosaccharomyces pombe (Fission yeast) TR:CAB60016 (EMBL:AL132779) (203 aa)%2C fasta scores opt: 275 z-score: 313.3 E(): 5.4e-10 25.7%25 identity in 175 aa overlap and Streptomyces coelicolor TR:CAB53436(EMBL:AL109989) SCJ12.24C (157 aa)%2C fasta scores opt: 139 z-score: 166.4 E(): 0.082 27.0%25 identity in 122 aa overlap. gene gene7434 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7371 SCO7372 SCO7372 SC9H11.26c SC9H11.26c 8185152 8185685 - hypothetical protein SC9H11.26c%2C unknown%2C len: 177 aa. gene gene7435 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7372 SCO7373 SCO7373 SC9H11.27c SC9H11.27c 8185841 8186332 - hypothetical protein SC9H11.27c%2C unknown%2C len: 163 aa. gene gene7436 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7373 SCO7374 SCO7374 narB narB 8186329 8188821 - nitrate reductase NarB (fragment) SC10G8.01c%2C possible oxidoreductase%2C partial CDS%2C len: > 355 aa. Similar to many e.g. Paracoccus denitrificans SW:NAPA_PARDT (EMBL:Z36773) periplasmic nitrate reductase precursor (EC 1.7.99.4) (831 aa)%2C fasta scores opt: 550 z-score: 651.4 E(): 7.2e-29 33.1%25 identity in 317 aa overlap.~SC9H11.28c%2C narB%2C nitrate reductase (EC 1.7.99.4)%2C partial CDS%2C len: > 508 aa. Highly similar to many including: Synechocystis sp. (strain PCC 7942) SW:NARB_SYNP7 (EMBL:X74597) nitrate reductase (EC 1.7.99.4)%2C NarB (729 aa)%2C fasta scores opt: 583 z-score: 613.8 E(): 1e-26 36.1%25 identity in 457 aa overlap and Oscillatoria chalybea TR:Q51328 (EMBL:X89445) nitrate reductase (EC 1.7.99.4)%2C NarB (737 aa)%2C fasta scores opt: 610 z-score: 642.1 E(): 2.6e-28 35.7%25 identity in 460 aa overlap. Contains a Prosite hit to PS00490 Prokaryotic molybdopterin oxidoreductases signature 2 and Pfam matches to entries PF00384 molybdopterin%2C Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding%2C Molydopterin dinucleotide binding domain. gene gene7437 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7374 SCO7375 SCO7375 SC10G8.02 SC10G8.02 8188898 8189692 + acetyltransferase SC10G8.02%2C possible acetyltransferase%2C len: 264 aa. Similar to Deinococcus radiodurans TR:AAF12253(EMBL:AE001862) acetyltransferase (210 aa)%2C fasta scores opt: 272 z-score: 314.3 E(): 4.3e-10 30.9%25 identity in 207 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. Contains a 7xDT repeat region in the C-terminus. gene gene7438 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7375 SCO7376 SCO7376 SC10G8.03c SC10G8.03c 8189725 8190453 - hypothetical protein SC10G8.03c%2C unknown%2C len: 242 aa. Weakly similar to Aeropyrum pernix TR:Q9Y911 (EMBL:AP000064) hypothetical protein (205 aa)%2C fasta scores opt: 226 z-score: 263.2 E(): 3e-07 31.8%25 identity in 211 aa overlap and to TR:CAC48481 (EMBL:AL603642) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMB20081%2C 236 aa%3B fasta scores: opt: 577 Z-score: 646.5 E(): 2.2e-28%3B 46.256%25 identity in 227 aa overlap gene gene7439 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7376 SCO7377 SCO7377 SC10G8.04c SC10G8.04c 8190450 8190707 - hypothetical protein SC10G8.04c%2C unknown%2C len: 85 aa. gene gene7440 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7377 SCO7378 SCO7378 SC10G8.05c SC10G8.05c 8190704 8191414 - hypothetical protein SC10G8.05c%2C unknown%2C len: 236 aa. gene gene7441 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7378 SCO7379 SCO7379 SC10G8.06 SC10G8.06 8191562 8191873 + hypothetical protein SC10G8.06%2C unknown%2C len: 103 aa. gene gene7442 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7379 SCO7380 SCO7380 SC10G8.07c SC10G8.07c 8191911 8193224 - hypothetical protein SC10G8.07c%2C unknown%2C len: 437 aa. Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein%2C SC9C7.20 (860 aa)%2C fasta scores opt: 271 z-score: 309.7 E(): 7.7e-10 30.3%25 identity in 274 aa overlap gene gene7443 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7380 SCO7381 SCO7381 SC10G8.08 SC10G8.08 8193260 8193673 + hypothetical protein SC10G8.08%2C unknown%2C len: 137 aa. gene gene7444 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7381 SCO7382 SCO7382 SC10G8.09c SC10G8.09c 8194036 8194350 - hypothetical protein SC10G8.09c%2C unknown%2C len: 104 aa. Weakly similar to a protein of unknown function from Streptomyces coelicolor TR:Q9Z548(EMBL:AL035212) hypothetical 11.6 KD protein%2C SC9B2.11 (109 aa)%2C fasta scores opt: 101 z-score: 134.7 E():4.5 35.1%25 identity in 74 aa overlap. gene gene7445 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7382 SCO7383 SCO7383 SC10G8.10 SC10G8.10 8194767 8195147 + hypothetical protein SC10G8.10%2C doubtful CDS%2C len: 126 aa. gene gene7446 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7383 SCO7384 SCO7384 SC10G8.11 SC10G8.11 8195889 8197229 + transmembrane transport protein SC10G8.11%2C possible transmembrane transport protein%2C len: 446 aa. Similar to many other transporters including: Streptomyces coelicolor TR:O69958(EMBL:AL022268) transmembrane transport protein%2C SC4H2.03C (411 aa)%2C fasta scores opt: 808 z-score: 828.6 E(): 0 37.9%25 identity in 414 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene7447 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7384 SCO7385 SCO7385 SC10G8.12 SC10G8.12 8197385 8197828 + hypothetical protein SC10G8.12%2C possible integral membrane protein%2C len: 147 aa. Contains possible membrane spanning hydrophobic domains. gene gene7448 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7385 SCO7386 SCO7386 SC10G8.13c SC10G8.13c 8198068 8199240 - serine protease SC10G8.13c%2C possible serine protease%2C len: 390 aa. Similar to many serine proteases e.g. Streptomyces griseus SW:PRTC_STRGR(EMBL:L29018) serine protease C precursor (EC 3.4.21.-) (457 aa)%2C fasta scores opt: 983 z-score: 1020.1 E(): 0 44.4%25 identity in 403 aa overlap and Streptomyces sp. TR:Q55353(EMBL:X74102) alkaline serine protease II (382 aa)%2C fasta scores opt: 959 z-score: 996.4 E():0 44.7%25 identity in 403 aa overlap. Contains a Prosite hits to PS00134 Serine proteases%2C trypsin family%2C histidine active site PS00135 Serine proteases%2C trypsin family%2C serine active site and a Pfam match to entry PF00089 trypsin%2C Trypsin. Also contains a possible N-terminal signal sequence. gene gene7449 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7386 SCO7387 SCO7387 SC10G8.14 SC10G8.14 8199503 8200009 + hypothetical protein SC10G8.14%2C unknown%2C len: 168 aa%3B similar to another from Streptomyces coelicolor SC8D11.07 TR:Q9AK12 (EMBL:AL512944) hypothetical protein fasta scores%3B opt: 426%2C Z-score: 537.3%2C E(): 2.7e-22%2C 46.763%25 identity (46.763%25 ungapped) in 139 aa overlap. gene gene7450 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7387 SCO7388 SCO7388 SC10G8.15 SC10G8.15 8200002 8201621 + dehydrogenase SC10G8.15%2C possible dehydrogenase%2C len: 539 aa. Similar to many including: Synechocystis sp. TR:Q55808(EMBL:D64004) phytoene dehydrogenase (542 aa)%2C fasta scores opt: 605 z-score: 655.2 E(): 4.5e-29 31.7%25 identity in 543 aa overlap and Rhodobacter sphaeroides SW:CRTD_RHOSH(EMBL:X63204) methoxyneurosporene dehydrogenase%2C CrtD (495 aa)%2C fasta scores opt: 268 z-score: 292.4 E(): 7.2e-09 28.2%25 identity in 528 aa overlap. gene gene7451 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7388 SCO7389 SCO7389 SC10G8.16 SC10G8.16 8201665 8202543 + short chain dehydrogenase SC10G8.16%2C possible oxidoreductase%2C len: 292 aa. Similar to many including: Streptomyces clavuligerus TR:O54197(EMBL:AJ000671) clavulanate-9-aldehyde reductase (247 aa)%2C fasta scores opt: 352 z-score: 389.3 E(): 2.9e-14 33.0%25 identity in 221 aa overlap and Streptomyces coelicolor TR:CAB59666(EMBL:AL132674) probable oxidoreductase%2C SCE87.21c (297 aa)%2C fasta scores opt: 931 z-score: 1011.4 E():0 52.8%25 identity in 286 aa overlap. Contains a Prosite hit PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene7452 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7389 SCO7390 SCO7390 SC10G8.17c SC10G8.17c 8202594 8203097 - gene gene7453 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7390 SCO7391 SCO7391 SC10G8.18 SC10G8.18 8203616 8203951 + gene gene7454 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7391 SCO7392 SCO7392 SC10G8.20 SC10G8.20 8204060 8204551 + hypothetical protein SC10G8.20%2C unknown%2C len: 163 aa. gene gene7455 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7392 SCO7393 SCO7393 SC10G8.21c SC10G8.21c 8204557 8205306 - lipoprotein SC10G8.21c%2C possible lipoprotein%2C len: 249 aa. Weakly similar to Streptomyces coelicolor SW:YRJ1_STRCO(EMBL:L24552) hypothetical protein in RplJ 5'region (Orf 1) (fragment) (>256 aa)%2C fasta scores opt: 120 z-score: 142.7 E(): 1.6 20.3%25 identity in 261 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7456 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7393 SCO7394 SCO7394 SC10G8.22 SC10G8.22 8205523 8206461 + hypothetical protein SC10G8.22%2C possible integral membrane protein%2C len: 312 aa. Similar to several proteins of undefined function e.g. Deinococcus radiodurans TR:AAF11939(EMBL:AE002070) Conserved hypothetical protein (304 aa)%2C fasta scores opt: 227 z-score: 259.6 E(): 4.8e-07 29.4%25 identity in 310 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene7457 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7394 SCO7395 SCO7395 SC10G8.23c SC10G8.23c 8206425 8207990 - membrane transport protein SC10G8.23c%2C possible membrane transport protein%2C len: 521 aa. Highly similar in several transport proteins involved in osmoregulation e.g. Escherichia coli SW:PROP_ECOLI(EMBL:M83089) proline/betaine transporter (proline porter II)%2C ProP (500 aa)%2C fasta scores opt: 1557 z-score: 1688.1 E():0 47.9%25 identity in 466 aa overlap. Contains Prosite hits to PS00217 Sugar transport proteins signature 2 and PS00216 Sugar transport proteins signature 1%2C as well as a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. Also contains multiple possible membrane spanning hydrophobic domains. gene gene7458 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7395 SCO7396 SCO7396 SC10G8.24c SC10G8.24c 8208050 8209387 - hypothetical protein SC10G8.24c. possible hypothetical protein%2C len: 445 aa. Weakly similar to Mycobacterium tuberculosis TR:O06598(EMBL:Z95586) hypothetical 48.0 KD protein (446 aa)%2C fasta scores opt: 399 z-score: 416.0 E(): 9.3e-16 28.2%25 identity in 387 aa overlap. Contains a possible N-terminal signal sequence. gene gene7459 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7396 SCO7397 SCO7397 SC10G8.25c SC10G8.25c 8209545 8210141 - hypothetical protein SC10G8.25c%2C unknown%2C len: 198 aa. Weakly similar to several e.g. Bacillus subtilis TR: O05231(EMBL:Z93933) hypothetical 23.8 KD protein (205 aa)%2C fasta scores opt: 213 z-score: 271.6 E(): 1e-07 28.2%25 identity in 181 aa overlap. gene gene7460 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7397 SCO7398 SCO7398 SC10G8.26c SC10G8.26c 8210201 8212285 - iron-hydroxamate transporter permease subunit part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome gene gene7461 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7398 SCO7399 SCO7399 SC10G8.27c SC10G8.27c 8212293 8213276 - binding-protein-dependent transport lipoprotein SC10G8.27c%2C possible binding-protein-dependent transport lipoprotein%2C len: 327 aa. Similar to many including: Escherichia coli SW:FHUD_ECOLI(EMBL:X05810) ferrichrome-binding periplasmic protein precursor FhuD (296 aa)%2C fasta scores opt: 231 z-score: 249.9 E(): 1.7e-06 24.8%25 identity in 270 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a Pfam match to entry PF01497 Peripla_BP_2%2C Periplasmic binding protein. gene gene7462 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7399 SCO7400 SCO7400 SC10G8.28c SC10G8.28c 8213273 8214151 - ABC transporter ATP-binding protein gene gene7463 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7400 SCO7401 SCO7401 SC10G8.29c SC10G8.29c 8214255 8214824 - hypothetical protein SC10G8.29c%2C unknown%2C len: 189 aa. Similar to Deinococcus radiodurans TR:AAF11944 (EMBL:AE002070) Conserved hypothetical protein (200 aa)%2C fasta scores opt: 394 z-score: 504.8 E(): 1.1e-20 42.9%25 identity in 156 aa overlap gene gene7464 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7401 SCO7402 SCO7402 SC10G8.30c SC10G8.30c 8214910 8216082 - lyase SC10G8.30c%2C possible lyase%2C len: 390 aa. Weakly similar to Bacillus subtilis SW:SPL_BACSU(EMBL:L08809) spore photoproduct lyase (EC 4.1.99.-)%2C SplB (342 aa)%2C fasta scores opt: 285 z-score: 328.4 E(): 7.1e-11 26.8%25 identity in 347 aa overlap. gene gene7465 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7402 SCO7403 SCO7403 SC10G8.31 SC10G8.31 8216238 8216423 + hypothetical protein SC10G8.31%2C membrane protein%2C len: 61 aa. Contains possible hydrophobic membrane spanning regions gene gene7466 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7403 SCO7404 SCO7404 SC10G8.32c SC10G8.32c 8216457 8217248 - hypothetical protein SC10G8.32c%2C unknown%2C len: 263 aa. Highly similar to a number of proteins of undefined function from Streptomyces coelicolor including: TR:O86541 (EMBL:AL031350) SC1F3.04 (261 aa)%2C fasta scores opt: 1155 z-score: 1354.8 E():0 67.9%25 identity in 262 aa overlap and TR:O86718 (EMBL:AL031515) SC5C7.21C (271 aa)%2C fasta scores opt: 894 z-score: 1050.3 E(): 0 54.0%25 identity in 272 aa overlap. gene gene7467 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7404 SCO7405 SCO7405 SC10G8.33c SC10G8.33c 8217360 8218007 - acetyltransferase SC6D11.01c%2C possible acetyltransferase%2C partial CDS%2C len: > 72 aa. Similar to the N-terminus of Escherichia coli SW:THGA_ECOLI(EMBL:J01636) galactoside O-acetyltransferase (EC 2.3.1.18) (203 aa)%2C fasta scores opt: 138 z-score: 187.9 E(): 0.0048 38.3%25 identity in 60 aa overlap. Overlaps and extends into CDS SC10G8.33c on the adjoining cosmid.~SC10G8.33c%2C possible acetyltransferase%2C partial CDS%2C len: > 175 aa. Highly similar to a number of acetyltransferases e.g. Escherichia coli SW:THGA_ECOLI(EMBL:J01636) galactoside o-acetyltransferase (EC 2.3.1.18) LacA (203 aa)%2C fasta scores opt: 592 z-score: 679.4 E(): 2e-30 48.8%25 identity in 160 aa overlap. Contains a Prosite hit to PS00101 Hexapeptide-repeat containing-transferases signature and a Pfam match to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats). gene gene7468 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7405 SCO7406 SCO7406 SC6D11.02c SC6D11.02c 8218101 8220176 - hypothetical protein SC6D11.02C%2C possible hypothetical protein%2C len: 691 aa. Contains a 8xGT repeat region within the C-terminus and a possible N-terminal signal sequence. gene gene7469 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7406 SCO7407 SCO7407 SC6D11.03c SC6D11.03c 8220304 8222349 - beta-galactosidase SC6D11.03c%2C probable beta-galactosidase%2C len: 681 aa. Similar to many beta-galactosidases e.g. Bacillus stearothermophilus SW:BGAL_BACST(EMBL:M13466) beta-galactosidase I (EC 3.2.1.23)%2C BgaB%2C (672 aa)%2C fasta scores opt: 1816 z-score: 2079.7 E(): 0 43.2%25 identity in 666 aa overlap. gene gene7470 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7407 SCO7408 SCO7408 SC6D11.04c SC6D11.04c 8222376 8223731 - solute-binding lipoprotein SC6D11.04c%2C probable solute-binding lipoprotein%2C len: 451 aa. Similar to several other transport proteins including: Agrobacterium radiobacter SW:LACE_AGRRD(EMBL:X66596) lactose-binding protein precursor%2C LacE (422 aa)%2C fasta scores opt: 347 z-score: 393.9 E(): 1.6e-14 24.0%25 identity in 425 aa overlap and Streptomyces coelicolor TR:CAB61177(EMBL:AL132973) probable solute-binding lipoprotein%2C SCF91.20 (443 aa)%2C fasta scores opt: 550 z-score: 621.9 E(): 3.2e-27 26.2%25 identity in 455 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a Prosite hit to PS01037 Bacterial extracellular solute-binding proteins%2C family 1 signature and a Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein. gene gene7471 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7408 SCO7409 SCO7409 SC6D11.05c SC6D11.05c 8223827 8224777 - binding-protein dependent transport protein SC6D11.05c%2C possible binding-protein dependent transport protein%2C len: 316 aa. Similar to many including: Streptomyces coelicolor TR:CAB61179(EMBL:AL132973) binding protein dependent transport protein%2C SCF91.22 (287 aa)%2C fasta scores opt: 875 z-score: 1002.5 E(): 0 45.9%25 identity in 281 aa overlap. Contains possible membrane spanning hydrophobic domains and a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene7472 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7409 SCO7410 SCO7410 SC6D11.06c SC6D11.06c 8224785 8225711 - binding-protein dependent transport protein SC6D11.06c%2C possible binding-protein dependent transport protein%2C len: 308 aa. Similar to many other transport proteins e.g. Streptomyces coelicolor TR:CAB61178(EMBL:AL132973) binding protein dependent transport protein%2C SCF91.21 (328 aa)%2C fasta scores opt: 622 z-score: 709.6 E(): 4.2e-32 35.9%25 identity in 315 aa overlap. Contains possible membrane spanning hydrophobic domains and a Prosite hit to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene7473 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7410 SCO7411 SCO7411 SC6D11.07 SC6D11.07 8225904 8226962 + LacI family transcriptional regulator SC6D11.07%2C possible LacI-family transcriptional regulator%2C len: 352 aa. Similar to several including Escherichia coli SW:LACI_ECOLI (EMBL:V00294) lactose operon repressor LacI (360 aa)%2C fasta scores opt: 595 z-score: 670.0 E(): 6.7e-30 34.8%25 identity in 333 aa overlap and Streptomyces coelicolor TR:O86618 (EMBL:AL031155) transcriptional regulator SC3A7.17 (361 aa)%2C fasta scores opt: 887 z-score: 995.3 E(): 0 46.0%25 identity in 350 aa overlap. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family. Possesses a helix-turn-helix motif situated between residues 23..44. gene gene7474 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7411 SCO7412 SCO7412 SC6D11.08 SC6D11.08 8227072 8228874 + thiamine pyrophosphate protein catalyzes the formation of acetate from pyruvate gene gene7475 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7412 SCO7413 SCO7413 SC6D11.09 SC6D11.09 8228871 8229902 + short chain dehydrogenase SC6D11.09%2C possible oxidoreductase%2C len: 343 aa. Highly similar to many oxidoreductases including: Mycobacterium tuberculosis TR:O53398(EMBL:AL021897) oxidoreductase (301 aa)%2C fasta scores opt: 405 z-score: 443.2 E(): 2.9e-17 36.2%25 identity in 257 aa overlap. Contains a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene7476 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7413 SCO7414 SCO7414 SC6D11.10 SC6D11.10 8229906 8230712 - hypothetical protein SC6D11.10%2C possible integral membrane protein%2C len: 268 aa. Contains possible membrane spanning hydrophobic domains. gene gene7477 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7414 SCO7415 SCO7415 SC6D11.11 SC6D11.11 8230865 8232022 + racemase SC6D11.11%2C possible racemase%2C len: 385 aa. Weakly similar to many racemases including: Pseudomonas putida SW:MANR_PSEPU(EMBL:M19043) mandelate racemase (EC 5.1.2.2) (359 aa)%2C fasta scores opt: 315 z-score: 373.7 E(): 2.1e-13 26.4%25 identity in 371 aa overlap and Streptomyces coelicolor TR:CAB55709(EMBL:AL117387) possible racemase%2C SCF41.06 (416 aa)%2C fasta scores opt: 383 z-score: 452.6 E(): 8.7e-18 31.0%25 identity in 371 aa overlap. Contains a Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family. gene gene7478 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7415 SCO7416 SCO7416 SC6D11.12c SC6D11.12c 8232052 8232456 - hypothetical protein SC6D11.12c%2C unknown%2C len: 134 aa. gene gene7479 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7416 SCO7417 SCO7417 SC6D11.13c SC6D11.13c 8232555 8233778 - cytochrome P450-family protein SC6D11.13c%2C possible cytochrome P450-family protein%2C len: 407 aa. Similar to many members of the cytochrome P450 family including: Streptomyces griseus SW:CPXH_STRGR (EMBL:X63601) cytochrome P450-soy (412 aa)%2C fasta scores opt: 673 z-score: 761.0 E():0 35.1%25 identity in 382 aa overlap and Saccharopolyspora erythraea (Streptomyces erythraeus) SW:CPXK_SACER (EMBL:M83110) cytochrome P450 107B1 (405 aa)%2C fasta scores opt: 872 z-score: 984.9 E():0 38.4%25 identity in 409 aa overlap. Contains a Prosite hit to PS00086 Cytochrome P450 cysteine heme-iron ligand signature and a Pfam match to entry PF00067 p450%2C Cytochrome P450. gene gene7480 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7417 SCO7418 SCO7418 SC6D11.14c SC6D11.14c 8233775 8235016 - cytochrome P450-family protein SC6D11.14c%2C possible cytochrome P450-family protein%2C len: 413 aa. Similar to many members of the cytochrome P450 family including: Saccharopolyspora erythraea (Streptomyces erythraeus) SW:CPXK_SACER(EMBL:M83110) cytochrome P450 107B1 (405 aa)%2C fasta scores opt: 491 z-score: 571.3 E(): 2.1e-24 28.9%25 identity in 395 aa overlap and Streptomyces coelicolor TR:CAB61278(EMBL:AL132991) cytochrome P450%2C SCF55.08c (420 aa)%2C fasta scores opt: 1375 z-score: 1593.6 E():0 51.7%25 identity in 404 aa overlap. gene gene7481 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7418 SCO7419 SCO7419 cvnD10 cvnD10 8235013 8235564 - ATP/GTP binding protein SC6D11.15c%2C cvnD10%2C possible ATP/GTP binding protein%2C len: 183 aa. Highly similar to many Streptomyces coelicolor ATP/GTP binding proteins e.g. TR:CAB61279 (EMBL:AL132991) SCF55.09c (178 aa)%2C fasta scores opt: 805 z-score: 986.9 E():0 73.7%25 identity in 167 aa overlap and TR:CAB59480 (EMBL:AL132648) SCI41.10c (176 aa)%2C fasta scores opt: 645 z-score: 793.2 E():0 61.3%25 identity in 168 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene7482 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7419 SCO7420 SCO7420 cvnC10 cvnC10 8235635 8235982 - hypothetical protein SC6D11.16c%2C cvnC10%2C unknown%2C len: 115 aa. Highly similar to many proteins of undefined function from Streptomyces coelicolor including: TR:CAB61280 (EMBL:AL132991) SCF55.10c. (113 aa)%2C fasta scores opt: 407 z-score: 530.3 E(): 4.1e-22 63.1%25 identity in 111 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa)%2C fasta scores opt: 249 z-score: 330.7 E(): 5.3e-11 46.2%25 identity in 117 aa overlap. gene gene7483 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7420 SCO7421 SCO7421 cvnB10 cvnB10 8235979 8236386 - hypothetical protein SC6D11.17c%2C cvnB10%2C unknown%2C len: 135 aa. Highly similar to many proteins of undefined function from Streptomyces coelicolor including: TR:CAB61281 (EMBL:AL132991) SCF55.11c (152 aa)%2C fasta scores opt: 634 z-score: 769.3 E():0 71.9%25 identity in 128 aa overlap and TR:Q9X835(EMBL:AL049727) SC9B1.15C (139 aa)%2C fasta scores opt: 329 z-score: 407.1 E(): 3e-15 40.9%25 identity in 132 aa overlap gene gene7484 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7421 SCO7422 SCO7422 cvnA10 cvnA10 8236383 8238014 - sensor histidine-kinase SC6D11.18c%2C cvnA10%2C possible sensor histidine-kinase%2C len: 543 aa. Similar to several from Streptomyces coelicolor including: TR:CAB61282 (EMBL:AL132991) sensor kinase%2C SCF55.12c (575 aa)%2C fasta scores opt: 969 z-score: 843.9 E(): 0 42.9%25 identity in 501 aa overlap and TR:CAB59483 (EMBL:AL132648) integral membrane protein%2C SCI41.13c (541 aa)%2C fasta scores opt: 630 z-score: 552.6 E(): 2.3e-23 32.9%25 identity in 559 aa overlap. Contains a Pfam match to entry PF00512 signal%2C Histidine kinase and a possible hydrophobic membrane spanning regions gene gene7485 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7422 SCO7423 SCO7423 SC6D11.19c SC6D11.19c 8238152 8238862 - hypothetical protein SC6D11.19c%2C unknown%2C len: 236 aa. Weakly similar to a protein of undefined function from Rhodococcus rhodochrous plasmid pKA22 TR:Q9XBN0(EMBL:AF165152) hypothetical 25.4 KD protein (242 aa)%2C fasta scores opt: 336 z-score: 419.4 E(): 6.1e-16 33.0%25 identity in 209 aa overlap. gene gene7486 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7423 SCO7424 SCO7424 SC6D11.20 SC6D11.20 8238961 8239428 + MarR family transcriptional regulator SC6D11.20%2C possible MarR-family transcriptional regulator%2C len: 155 aa. Weakly similar to Streptomyces coelicolor TR:CAB56677 (EMBL:AL121596) MarR-family protein%2C SCF51A.25 (148 aa)%2C fasta scores opt: 209 z-score: 254.7 E(): 9.1e-07 33.1%25 identity in 124 aa overlap. Contains a Pfam match to entry PF01047 MarR%2C MarR family with the helix-turn-helix motif situated between residues 53..74 (+4.29 SD). gene gene7487 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7424 SCO7425 SCO7425 SC6D11.21 SC6D11.21 8239425 8241158 + multidrug-efflux transporter SC6D11.21%2C possible multidrug-efflux transporter%2C len: 577 aa. Highly similar to several including: Streptomyces virginiae TR:Q9XE01(EMBL:AB019519) virginiamycin S resistance protein%2C VarS (518 aa)%2C fasta scores opt: 322 z-score: 328.6 E(): 7e-11 25.7%25 identity in 536 aa overlap and Deinococcus radiodurans TR:AAF11851(EMBL:AE002062) multidrug-efflux transporter%2C (410 aa)%2C fasta scores opt: 937 z-score: 945.6 E(): 0 41.3%25 identity in 395 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and multiple possible membrane spanning hydrophobic domains. gene gene7488 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7425 SCO7426 SCO7426 SC6D11.22c SC6D11.22c 8241248 8241685 - hypothetical protein SC6D11.22c%2C unknown%2C len: 145 aa. gene gene7489 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7426 SCO7427 SCO7427 SC6D11.23 SC6D11.23 8241835 8242281 + hypothetical protein SC6D11.23%2C unknown%2C len: 148 aa. Similar to several proteins of undefined function e.g. Vibrio parahaemolyticus SW:YJEB_VIBPA(EMBL:U09005) hypothetical 15.6 KD protein (141 aa)%2C fasta scores opt: 292 z-score: 356.7 E(): 1.9e-12 39.7%25 identity in 146 aa overlap. gene gene7490 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7427 SCO7428 SCO7428 hmpA1 hmpA1 8242355 8243551 + flavohemoprotein SC6D11.24%2C hmpA1%2C possible flavohemoprotein%2C len: 398 aa. Highly similar to many protein of the flavohemoprotein subfamily%2C including: Escherichia coli SW:HMPA_ECOLI(EMBL:X58872) flavohemoprotein (hemoglobin-like protein) (396 aa)%2C fasta scores: opt: 826 z-score: 935.2 E():0 39.4%25 identity in 404 aa overlap and Erwinia chrysanthemi SW:HMPA_ERWCH (EMBL:X75893) flavohemoprotein (395 aa)%2C fasta scores: opt: 761 z-score: 862.0 E():0 35.9%25 identity in 404 aa overlap. Contains Pfam matches to entries Pfam match to entry PF00042 globin%2C Globin and Pfam match to entry PF00175 oxidored_fad%2C Oxidoreductase FAD/NAD-binding domain. gene gene7491 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7428 SCO7429 SCO7429 SC6D11.25c SC6D11.25c 8243600 8243950 - hypothetical protein SC6D11.25c%2C unknown%2C len: 116 aa. gene gene7492 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7429 SCO7430 SCO7430 SC6D11.26 SC6D11.26 8244126 8244812 + hypothetical protein SC6D11.26%2C unknown%2C len: 228 aa. Contains a Pfam match to entry PF01955 DUF105%2C Domain of unknown function. gene gene7493 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7430 SCO7431 SCO7431 SC6D11.27c SC6D11.27c 8244832 8245092 - hypothetical protein SC6D11.27c%2C possible integral membrane protein%2C len: 86 aa. Contains possible membrane spanning hydrophobic domains. gene gene7494 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7431 SCO7432 SCO7432 mprA2 mprA2 8245226 8245909 - extracellular small neutral protease SC6D11.28c%2C mprA2%2C extracellular small neutral protease (EC 3.4.24.-)%2C len: 227 aa. Identical to Streptomyces lividans SW:SNPA_STRLI(EMBL:M81703) extracellular small neutral protease precursor%2C SnpA (227 aa)%2C fasta scores opt: 1483 z-score: 1546.5 E(): 0 100.0%25 identity in 227 aa overlap. Also highly similar to Streptomyces coelicolor SW:SNPA_STRCO(EMBL:Z11929) extracellular small neutral protease precursor%2C MprA (215 aa)%2C fasta scores opt: 854 z-score: 896.8 E():0 65.6%25 identity in 218 aa overlap. Contains a possible N-terminal signal sequence. gene gene7495 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7432 SCO7433 SCO7433 mprR2 mprR2 8246125 8247111 + small neutral protease regulatory protein SC6D11.29%2C mprR2%2C small neutral protease regulatory protein%2C len: 328 aa. Almost identical to Streptomyces lividans SW:SNPR_STRLI (EMBL:M81703) small neutral protease regulatory protein (344 aa)%2C fasta scores opt: 2123 z-score: 2481.6 E(): 0 98.5%25 identity in 327 aa overlap. Also highly similar to Streptomyces coelicolor SW:MPRR_STRCO (EMBL:Z11929) small neutral protease regulatory protein%2C MprR (316 aa)%2C fasta scores opt: 1163 z-score: 1362.7 E():0 60.7%25 identity in 323 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins%2C lysR family signature and a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family with the helix-turn-helix motif situated between residues 18..39 (+4.38 SD). gene gene7496 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7433 SCO7434 SCO7434 SC6D11.30 SC6D11.30 8247219 8247980 + lipoprotein SC6D11.30%2C possible lipoprotein%2C len: 253 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7497 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7434 SCO7435 SCO7435 SC6D11.31c SC6D11.31c 8248054 8249322 - transmembrane transport protein SC6D11.31c%2C possible transmembrane transport protein%2C len: 422 aa. Similar to many transport proteins e.g. Acinetobacter sp. TR:O30513(EMBL:AF009224) benzoate transport protein%2C BenK (466 aa)%2C fasta scores opt: 423 z-score: 455.2 E(): 6.2e-18 31.1%25 identity in 421 aa overlap. Contains a Prosite hit to PS00216 Sugar transport proteins signature 1 and a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. Contains multiple possible membrane spanning hydrophobic domains. gene gene7498 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7435 SCO7436 SCO7436 SC6D11.32c SC6D11.32c 8249413 8250867 - aldehyde dehydrogenase SC6D11.32c%2C probable aldehyde dehydrogenase%2C len: 484 aa. Highly similar to many dehydrogenases including: Pseudomonas putida SW:XYLC_PSEPU(EMBL:U15151) benzaldehyde dehydrogenase [NAD+] (EC 1.2.1.28) (487 aa)%2C fasta scores opt: 1519 z-score: 1634.7 E():0 47.6%25 identity in 483 aa overlap and Streptomyces coelicolor TR:Q9X8J9(EMBL:AL049841) aldehyde dehydrogenase%2C SCE9.27C (486 aa)%2C fasta scores opt: 1215 z-score: 1308.5 E():0 43.1%25 identity in 476 aa overlap. Contains a Prosite hit to PS00687 Aldehyde dehydrogenases glutamic acid active site and a Pfam match to entry PF00171 aldedh%2C Aldehyde dehydrogenase family. gene gene7499 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7436 SCO7437 SCO7437 SC6D11.33c SC6D11.33c 8250914 8252494 - benzoylformate decarboxylase catalyzes the formation of benzaldehyde from benzoylformate gene gene7500 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7437 SCO7438 SCO7438 SC6D11.34 SC6D11.34 8252589 8253524 + LysR family transcriptional regulator SC6D11.34%2C possible LysR-family transcriptional regulatory protein%2C len: 311 aa. Similar to many LysR-family regulators involved in the control of nodulation e.g. Rhizobium sp. (strain NGR234) SW:NOD1_RHISN(EMBL:AE000065) nodulation protein D I (322 aa)%2C fasta scores opt: 449 z-score: 537.5 E(): 1.6e-22 32.3%25 identity in 294 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins%2C lysR family signature and Pfam matches to PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and Pfam match to entry PF01046 NodD_C_term%2C NodD transcription activator carboxyl terminal region. The helix-turn-helix motif situated between residues 19..40 (+4.28 SD). gene gene7501 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7438 SCO7439 SCO7439 SC6D11.35 SC6D11.35 8253535 8254275 + hypothetical protein SC6D11.35%2C unknown%2C len: 246 aa. Weakly similar to a protein of undefined function from Bacillus subtilis TR:P71089(EMBL:Z82044) (251 aa)%2C fasta scores opt: 424 z-score: 507.0 E(): 8e-21 35.4%25 identity in 209 aa overlap gene gene7502 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7439 SCO7440 SCO7440 SC6D11.36c SC6D11.36c 8254317 8255261 - hydrolase SC6D11.36c%2C possible hydrolase%2C len: 314 aa. Similar to several including Moraxella sp. SW:DEH1_MORSP (EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa). fasta scores opt: 356 z-score: 414.9 E(): 1.1e-15 27.9%25 identity in 297 aa overlap and Streptomyces coelicolor TR:O86546 (EMBL:AL031350) hydrolase%2C SC1F2.09C (309 aa)%2C fasta scores opt: 498 z-score: 577.2 E(): 9.9e-25 35.2%25 identity in 307 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold. gene gene7503 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7440 SCO7441 SCO7441 SC6D11.37 SC6D11.37 8255348 8255941 + transcriptional regulator SC6D11.37%2C possible transcriptional regulatory protein%2C len: 197 aa. Similar to several regulators e.g. Streptomyces lividans TR:O85695(EMBL:AF072709) transcriptional regulator (192 aa)%2C fasta scores opt: 170 z-score: 212.6 E(): 0.0002 29.7%25 identity in 192 aa overlap. Contains a possible helix-turn-helix motif situated between residues 29..50 (+3.58 SD). gene gene7504 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7441 SCO7442 SCO7442 SC6D11.38 SC6D11.38 8256100 8256564 + hypothetical protein SC6D11.38%2C unknown%2C len: 154 aa. Rich in the amino acid Ala. gene gene7505 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7442 SCO7443 SCO7443 pgm pgm 8256653 8258293 + phosphoglucomutase catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate gene gene7506 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7443 SCO7444 SCO7444 SC5C11.01c SC5C11.01c 8258333 8259604 - cytochrome P450 (fragment) SC5C11.01c%2C possible cytochrome P450%2C partial CDS%2C len:> 40 aa. This CDS forms the N-terminus of SC6D11.40c%2C carried on the adjoining cosmid%2C which is weakly similar to many cytochrome P450's. This similarity is lost in this portion of the predicted protein.~SC6D11.40c%2C possible cytochrome P450%2C partial CDS%2C len:> 421 aa. Weakly similar to many cytochrome P450's including: Saccharopolyspora erythraea (Streptomyces erythraeus) SW:CPXQ_SACER(EMBL:U82823) cytochrome P450 113A1 (erythromycin B/D C-12 hydroxylase) (397 aa)%2C opt: 259 z-score: 300.0 E(): 2.7e-09 30.5%25 identity in 361 aa overlap. Overlaps and extends into CDS SC5C11.01c on the adjoining cosmid. Contains a Prosite hit to PS00086 Cytochrome P450 cysteine heme-iron ligand signature and a Pfam match to entry PF00067 p450%2C Cytochrome P450. gene gene7507 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7444 SCO7445 SCO7445 SC5C11.02 SC5C11.02 8259792 8260529 + hypothetical protein SC5C11.02%2C unknown%2C len: 245 aa. Weakly similar to Escherichia coli SW:YJHP_ECOLI(EMBL:U14003) hypothetical 27.4 KD protein (248 aa)%2C fasta scores opt: 301 z-score: 358.4 E(): 1.5e-12 28.2%25 identity in 248 aa overlap. gene gene7508 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7445 SCO7446 SCO7446 SC5C11.03 SC5C11.03 8260631 8261071 + regulator SC5C11.03%2C possible regulator%2C len: 146 aa. Similar to Streptomyces fradiae TR:Q9Z9I5 (EMBL:AB024056) beta-lactamase regulator protein (139 aa)%2C fasta scores opt: 215 z-score: 266.6 E(): 2e-07 36.6%25 identity in 131 aa overlap and Streptomyces coelicolor TR:Q9X7S3 (EMBL:AL049863) regulator protein%2C SC5H1.15C (151 aa)%2C fasta scores opt: 347 z-score: 419.9 E(): 5.7e-16 44.4%25 identity in 144 aa overlap. gene gene7509 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7446 SCO7447 SCO7447 SC5C11.04c SC5C11.04c 8261520 8262071 - acetyltranferase SC5C11.04c possible acetyltranferase%2C len: 183 aa. Similar to many including: Proteus mirabilis TR:O86434(EMBL:AJ000084) acetyl transferase (185 aa)%2C fasta scores opt: 428 z-score: 512.9 E(): 3.8e-21 43.6%25 identity in 179 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene7510 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7447 SCO7448 SCO7448 SC5C11.05 SC5C11.05 8262207 8264150 + hypothetical protein SC5C11.05%2C unknown%2C len: 647 aa. Similar to another protein of undefined function from Streptomyces coelicolor TR:Q9X8W1(EMBL:AL078610) hypothetical 66.2 KD protein%2C SCH35.45c (634 aa)%2C fasta scores opt: 1537 z-score: 1606.6 E(): 0 46.3%25 identity in 570 aa overlap. Contains a Pfam match to entry PF00989 PAS%2C PAS domain. gene gene7511 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7448 SCO7449 SCO7449 SC5C11.06 SC5C11.06 8264413 8265090 + hypothetical protein SC5C11.06%2C possible /membrane protein%2C len: 225 aa. Contains repeat sequences 3xGDW(N/D)HDD(S/T/A)S(Y/S)(S/G)KEHDNGSKHDEPRGG%2C 3xMHTGGG(A/G)LAV(T/N)E and 1xMHTGGGGLA. Also contains possible N-terminal region signal sequence peptide and possible membrane spanning hydrophobic domains. gene gene7512 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7449 SCO7450 SCO7450 SC5C11.07 SC5C11.07 8265291 8265896 + hypothetical protein SC5C11.07%2C possible hypothetical protein%2C len: 201 aa. Similar to Streptomyces coelicolor TR:CAB63184 (EMBL:AL133469) hypothetical protein%2C SCM10.23 (221 aa)%2C fasta scores opt: 512 z-score: 527.4 E(): 5.9e-22 41.4%25 identity in 198 aa overlap. Contains a possible N-terminal signal sequence. gene gene7513 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7450 SCO7451 SCO7451 SC5C11.08 SC5C11.08 8266048 8267244 + hypothetical protein SC5C11.08%2C unknown%2C len: 398 aa. Highly similar to several proteins of undefined function associated with polyketide biosynthesis including: Streptomyces coelicolor SW:WH42_STRCO(EMBL:X55942) 42.8 KD protein in whiE locus (WhiE ORF I) SC6G9.13 (397 aa)%2C fasta scores opt: 1392 z-score: 1637.1 E():0 56.1%25 identity in 401 aa overlap and Streptomyces cyaneus (Streptomyces curacoi) SW:CURD_STRCN(EMBL:X62518) polyketide synthase%2C CurD (367 aa)%2C fasta score opt: 1451 z-score: 1706.9 E():0 62.0%25 identity in 368 aa overlap. gene gene7514 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7451 SCO7452 SCO7452 SC5C11.09c SC5C11.09c 8267283 8268311 - O-methyltransferase SC5C11.09c%2C possible O-methyltransferase%2C len: 342 aa. Similar to many e.g. Streptomyces glaucescens SW:TCMN_STRGA (EMBL:M80674) multi-functional cyclase-dehydratase-3-O-methyl transferase%2C TcmN%2C forming the first step in the biosynthesis of the polyketide antibiotic tetracenomycin C (494 aa)%2C fasta scores opt: 472 z-score: 554.8 E(): 1.8e-23 30.8%25 identity in 308 aa overlap and Streptomyces lavendulae TR:Q9X5T6(EMBL:AF127374) O-methyltransferase%2C MmcR%2C found within the mitomycin C biosynthetic cluster (351 aa)%2C fasta scores opt: 654 z-score: 769.9 E(): 0 37.1%25 identity in 340 aa overlap. Contains a Pfam match to entry PF00891 Methyltransf_2%2C O-methyltransferase. gene gene7515 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7452 SCO7453 SCO7453 SC5C11.10c SC5C11.10c 8268376 8269446 - hypothetical protein SC5C11.10c%2C hypothetical protein%2C len: 356 aa. Contains possible N-terminal region signal peptide sequence gene gene7516 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7453 SCO7454 SCO7454 SC5C11.11 SC5C11.11 8269590 8270384 + hypothetical protein SC5C11.11%2C possible membrane protein%2C len: 264 aa. Contains possible membrane spanning hydrophobic domains. gene gene7517 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7454 SCO7455 SCO7455 SC5C11.12 SC5C11.12 8270459 8270995 + isochorismatase SC5C11.12%2C possible isochorismatase (EC 3.3.2.1)%2C len: 178 aa. Similar to several including: Escherichia coli SW:ENTB_ECOLI(EMBL:M24148) isochorismatase (EC 3.3.2.1)%2C EntB%2C involved in enterobactin biosynthesis (285 aa)%2C fasta scores opt: 210 z-score: 266.3 E(): 2.1e-07 26.3%25 identity in 179 aa overlap. Contains a Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family. gene gene7518 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7455 SCO7456 SCO7456 SC5C11.13c SC5C11.13c 8271037 8271528 - hypothetical protein SC5C11.13c%2C unknown%2C len: 163 aa. gene gene7519 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7456 SCO7457 SCO7457 SC5C11.14c SC5C11.14c 8271571 8271969 - hypothetical protein SC5C11.14c%2C unknown%2C len: 132 aa. gene gene7520 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7457 SCO7458 SCO7458 SC5C11.15 SC5C11.15 8272128 8272493 + hypothetical protein SC5C11.15%2C possible membrane protein%2C len: 121 aa. Similar in parts to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:O53879(EMBL:AL022004) hypothetical 40.0 KD protein (407 aa)%2C fasta scores opt: 331 z-score: 403.1 E(): 4.9e-15 50.0%25 identity in 108 aa overlap. Contains a possible membrane spanning hydrophobic domain. gene gene7521 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7458 SCO7459 SCO7459 SC5C11.16c SC5C11.16c 8272690 8273529 - ABC transporter ATP-binding protein gene gene7522 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7459 SCO7460 SCO7460 SC5C11.17 SC5C11.17 8273736 8274806 + lipoprotein SC5C11.17%2C possible lipoprotein%2C len: 356 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7523 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7460 SCO7461 SCO7461 SCBAC14E8.01c SCBAC14E8.01c 8274847 8275533 - hydrolase SCBAC14E8.01c%2C probable hydrolase%2C len: 228 aa%3B similar to SW:TRYD_DROME (EMBL:U04853) Drosophila melanogaster trypsin delta precursor (EC 3.4.21.4) Try-delta%2C 253aa%3B fasta scores: opt: 220 Z-score: 237.9 bits: 51.4 E(): 1.1e-05%3B 32.271%25 identity in 251 aa overlap. Contains Pfam match to entry PF00089 trypsin%2C Trypsin gene gene7524 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7461 SCO7462 SCO7462 SCBAC14E8.02c SCBAC14E8.02c 8275745 8276512 - hypothetical protein SCBAC14E8.02c%2C possible integral membrane protein%2C len: 255 aa%3B similar to TR:Q49657 (EMBL:U00011) Mycobacterium leprae hypothetical 27.1 kDa protein U1177B precursor MLCL581.28c%2C 260 aa%3B fasta scores: opt: 670 Z-score: 780.5 bits: 152.0 E(): 6.8e-36%3B 47.059%25 identity in 255 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7525 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7462 SCO7463 SCO7463 cvnA13 cvnA13 8276830 8278032 + sensor histidine kinase SCBAC14E8.03%2C cvnA13%2C possible sensor histidine kinase%2C len: 400 aa%3B similar to TR:Q9L137 (EMBL:AL158061) Streptomyces coelicolor sensor histidine-kinase SC6D11.18c%2C 543 aa%3B fasta scores: pt: 500 Z-score: 444.9 bits: 91.6 E(): 3.3e-17%3B 32.591%25 identity in 359 aa overlap and to TR:Q9AJP4 (EMBL:AB044803) Streptomyces griseus ORF1%2C 543 aa%3B fasta scores: opt: 511 Z-score: 495.4 E(): 5.8e-20%3B 34.627%25 identity in 335 aa overlap. Contains Pfam match to entry PF02518 HATPase_c%2C Histidine kinase-%2C DNA gyrase B-%2C phytochrome-like ATPase and possible N-terminal region signal peptide sequence gene gene7526 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7463 SCO7464 SCO7464 cvnB13 cvnB13 8278029 8278430 + hypothetical protein SCBAC14E8.04%2C cvnB13%2C hypothetical protein%2C len: 133 aa%3B similar to TR:Q9L138 (EMBL:AL158061) Streptomyces coelicolor hypothetical 14.a kDa protein SC6D11.17c%2C 135 aa%3B fasta scores: opt: 321 Z-score: 425.0 bits: 84.4 E(): 4.3e-16%3B 40.476%25 identity in 126 aa overlap gene gene7527 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7464 SCO7465 SCO7465 cvnC13 cvnC13 8278427 8278804 + hypothetical protein SCBAC14E8.05%2C cvnC13%2C hypothetical protein%2C len: 125 aa%3B similar to TR:Q9X834 (EMBL:AL049727) Streptomyces coelicolor hypothetical 12.8 kDa protein SC9B1.14c%2C 119 aa%3B fasta scores: opt: 288 Z-score: 370.8 bits: 74.1 E(): 4.5e-13%3B 45.082%25 identity in 122 aa overlap. Contains a TTA leucine codon%2C possible target for bldA regulation gene gene7528 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7465 SCO7466 SCO7466 cvnD13 cvnD13 8278842 8279372 + ATP/GTP-binding protein SCBAC14E8.06%2C cvnD13%2C possible ATP/GTP-binding protein%2C len: 176 aa%3B similar to TR:Q9XAE1 (EMBL:AL079356) Streptomyces coelicolor ATP/GTP-binding protein SC6G9.41c%2C 191 aa%3B fasta scores: opt: 615 Z-score: 755.2 bits: 146.4 E(): 1.7e-34%3B 55.172%25 identity in 174 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene7529 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7466 SCO7467 SCO7467 SCBAC14E8.07 SCBAC14E8.07 8279637 8280764 + hypothetical protein SCBAC14E8.07%2C unknown%2C len: 375 aa gene gene7530 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7467 SCO7468 SCO7468 SCBAC14E8.08c SCBAC14E8.08c 8280867 8282165 - flavin-binding monooxygenase SCBAC17A6.01c%2C possible flavin-containing monooxygenase%2C len: >327aa: similar to many eg. TR:Q9S204 (EMBL:AL109747) flavin-containing monooxygenase SCJ21.03 from Streptomyces coelicolor (458 aa) fasta scores%3B opt: 909%2C Z-score: 1021.7%2C 45.399%25 identity (45.679%25 ungapped) in 326 aa overlap and SW:P31513 (FMO3_HUMAN) hepatic flavin-containing monooxygenase FMO3 (defects in which cause fish-odour syndrome) (531 aa) fasta scores%3B opt: 661%2C Z-score: 743.2%2C 34.024%25 identity (35.826%25 ungapped) in 338 aa overlap. Contains Pfam match to entry PF00743 FMO-like%2C Flavin-binding monooxygenase-like.~SCBAC14E8.08c%2C possible monooxigenase (fragment)%2C len: >140 aa%3B similar to C-terminal region of SW:FMO5_RABIT (EMBL:L08449) Oryctolagus cuniculus dimethylaniline monooxygenase [N-oxide forming] 5 (EC 1.14.13.8) Fmo5%2C 532 aa%3B fasta scores: opt: 259 Z-score: 319.3 bits: 66.9 E(): 3.3e-10%3B 32.353%25 identity in 136 aa overlap gene gene7531 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7468 SCO7469 SCO7469 paaK paaK 8282277 8283623 - phenylacetate-CoA ligase SCBAC17A6.02c%2C phenylacetate-CoA ligase%2C len: 448 aa: strongly similar to many e.g. TR:Q9L9C1 (EMBL:AF176259) aerobic phenylacetate-CoA ligase from Azoarcus evansii (440 aa) fasta scores%3B opt: 1896%2C Z-score: 2065.6%2C 63.825%25 identity (64.871%25 ungapped) in 434 aa overlap. Contains 2 Pfam matches to entry PF00501 AMP-binding%2C AMP-binding enzyme. gene gene7532 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7469 SCO7470 SCO7470 paaI paaI 8283620 8284132 - phenylacetic acid degradation protein PaaI SCBAC17A6.03c%2C possible phenylacetic acid degradation protein PaaI%2C len: 170 aa: similar to many e.g. SW:P76084 (PAAI_ECOLI) phenylacetic acid degradation protein PaaI from Escherichia coli (140 aa) fasta scores%3B opt: 342%2C Z-score: 414.6%2C 45.902%25 identity (46.281%25 ungapped) in 122 aa overlap. Contains Pfam match to entry PF02584 DUF157%2C Uncharacterized protein PaaI. gene gene7533 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7470 SCO7471 SCO7471 paaA paaA 8284297 8285283 + phenylacetate-CoA oxygenase subunit PaaA with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA gene gene7534 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7471 SCO7472 SCO7472 paaB paaB 8285280 8285591 + phenylacetate-CoA oxygenase subunit PaaB with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA%3B involved in phenylacetate degradation gene gene7535 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7472 SCO7473 SCO7473 paaC paaC 8285601 8286428 + phenylacetic acid degradation protein PaaC SCBAC17A6.06%2C possible phenylacetic acid degradation protein PaaC%2C len: 275 aa: similar to many e.g. SW:P76079 (PAAC_ECOLI) phenylacetic acid degradation protein PaaC from Escherichia coli (248 aa) fasta scores%3B opt: 470%2C Z-score: 547.8%2C 41.057%25 identity (44.105%25 ungapped) in 246 aa overlap. gene gene7536 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7473 SCO7474 SCO7474 paaD paaD 8286425 8286937 + phenylacetic acid degradation protein PaaD SCBAC17A6.07%2C possible phenylacetic acid degradation protein PaaD%2C len: 170 aa: similar to many e.g. SW:P76080 (PAAD_ECOLI) phenylacetic acid degradation protein PaaD from Escherichia coli (167 aa) fasta scores%3B opt: 474%2C Z-score: 518.6%2C 45.395%25 identity (47.586%25 ungapped) in 152 aa overlap. Contains Pfam match to entry PF01883 DUF59%2C Domain of unknown function DUF59. gene gene7537 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7474 SCO7475 SCO7475 SCBAC17A6.08 SCBAC17A6.08 8286937 8288043 + phenylacetic acid degradation NADH oxidoreductase PaaE SCBAC17A6.08%2C possible phenylacetic acid degradation NADH oxidoreductase PaaE%2C len: 368 aa%3B similar to many e.g. SW:P76081 (PAAE_ECOLI) probable phenylacetic acid degradation NADH oxidoreductase PaaE from Escherichia coli (356 aa) fasta scores%3B opt: 871%2C Z-score: 943.6%2C 39.943%25 identity (40.870%25 ungapped) in 353 aa overlap. Contains Pfam match to entry PF00111 fer2%2C 2Fe-2S iron-sulfur cluster binding domains%3B Pfam match to entry PF00175 NAD_binding%2C Oxidoreductase FAD/NAD-binding domain%3B Pfam match to entry PF00970 FAD_binding_6%2C Oxidoreductase FAD-binding domain and Prosite match to PS00197 2Fe-2S ferredoxins%2C iron-sulfur binding region signature. gene gene7538 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7475 SCO7476 SCO7476 SCBAC17A6.09c SCBAC17A6.09c 8288251 8289468 - hypothetical protein SCBAC17A6.09c%2C possible hypothetical protein%2C len: 405aa: no significant database matches. Contains a possible N-terminal signal sequence. gene gene7539 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7476 SCO7477 SCO7477 SCBAC17A6.10 SCBAC17A6.10 8289725 8291218 + hypothetical protein SCBAC17A6.10%2C possible membrane protein%2C len: 497 aa: no significant database matches. Contains a possible hydrophobic membrane spanning region and Prosite match to PS00216 Sugar transport proteins signature 1. gene gene7540 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7477 SCO7478 SCO7478 SCBAC17A6.11c SCBAC17A6.11c 8291215 8292117 - phosphotransferase SCBAC17A6.11c%2C possible phosphotransferase%2C len: 300aa: similar to many some of which are antibiotic resistance determinants eg. TR:O05841 (EMBL:Z95120) hypothetical protein from Mycobacterium tuberculosis (474 aa) fasta scores%3B opt: 971%2C Z-score: 1047.4%2C 49.315%25 identity (50.000%25 ungapped) in 292 aa overlap and TR:Q53826 (EMBL:U13078) capreomycin phosphotransferase from Streptomyces capreolus (281 aa) fasta scores%3B opt: 162%2C Z-score: 183.1%2C 28.632%25 identity (30.734%25 ungapped) in 234 aa overlap. Contains Pfam match to entry PF01636 APH%2C Aminoglycoside phosphotransferase. gene gene7541 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7478 SCO7479 SCO7479 SCBAC17A6.12c SCBAC17A6.12c 8292151 8293314 - hypothetical protein SCBAC17A6.12c%2C possible integral membrane protein%2C len: 387aa: similar to many eg. TR:Q9FAT6 (EMBL:AB038042) Mrx hypothetical protein associated with macrolide 2'-phosphotransferase I in Escherichia coli plasmid pTZ3509 (412 aa) fasta scores%3B opt: 316%2C Z-score: 317.3%2C 29.873%25 identity (31.978%25 ungapped) in 395 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene7542 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7479 SCO7480 SCO7480 SCBAC17A6.13 SCBAC17A6.13 8293353 8293976 + hypothetical protein SCBAC17A6.13%2C conserved hypothetical protein%2C len: 207aa: similar to many from streptomycetes eg. TR:Q9L267 (EMBL:AL137778) hypothetical protein SCL2.32 from Streptomyces coelicolor (186 aa) fasta scores%3B opt: 221%2C Z-score: 262.6%2C 31.928%25 identity (32.515%25 ungapped) in 166 aa overlap. gene gene7543 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7480 SCO7481 SCO7481 SCBAC17A6.14c SCBAC17A6.14c 8293977 8294552 - hypothetical protein SCBAC17A6.14c%2C conserved hypothetical protein%2C len: 191aa: similar to many eg. TR:Q9F2L4 (EMBL:AL442629) hypothetical protein from Streptomyces coelicolor (151 aa) fasta scores%3B opt: 588%2C Z-score: 595.0%2C 65.185%25 identity (65.185%25 ungapped) in 135 aa overlap and TR:Q52355 (EMBL:U59239) TerB tellurite resistance protein from Serratia marcescens plasmid R478 (151 aa) fasta scores%3B opt: 240%2C Z-score: 254.3%2C 28.467%25 identity (28.467%25 ungapped) in 137 aa overlap gene gene7544 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7481 SCO7482 SCO7482 SCBAC17A6.15 SCBAC17A6.15 8294744 8295145 + hypothetical protein SCBAC17A6.15%2C possible integral membrane protein%2C len: 133aa: appears to have a motif in common with others eg. TR:Q9L4T7 (EMBL:AF265258) dolichyl-phosphate beta-glucosyltransferase from Rhodococcus sp. S9 (449 aa) fasta scores%3B opt: 215%2C Z-score: 268.3%2C 40.310%25 identity (41.935%25 ungapped) in 129 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene7545 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7482 SCO7483 SCO7483 SCBAC17A6.16 SCBAC17A6.16 8295316 8295723 + hypothetical protein SCBAC17A6.16%2C conserved hypothetical protein%2C len: 135aa: similar to many eg. TR:BAB48518 (EMBL:AP002996) hypothetical protein MLL1058 from Rhizobium loti (148 aa) fasta scores%3B opt: 285%2C Z-score: 348.9%2C 39.850%25 identity (41.732%25 ungapped) in 133 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C YjgF family. gene gene7546 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7483 SCO7484 SCO7484 SCBAC17A6.17c SCBAC17A6.17c 8295730 8295966 - hypothetical protein SCBAC17A6.17c%2C unknown%2C len: 78 aa: no significant database matches. gene gene7547 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7484 SCO7485 SCO7485 SCBAC17A6.18c SCBAC17A6.18c 8295963 8296649 - oxidoreductase SCBAC17A6.18c%2C possible oxidoreductase%2C len: 228aa%3B similar to many eg. TR:Q9L2J5 (EMBL:AL137165) oxidoreductase SCF42.24 from Streptomyces coelicolor (295 aa) fasta scores%3B opt: 450%2C Z-score: 508.6%2C 43.850%25 identity (45.304%25 ungapped) in 187 aa overlap and TR:BAB49857 (EMBL:AP003000) probable oxidoreductase from Rhizobium loti (319 aa) fasta scores%3B opt: 243%2C Z-score: 278.7%2C 31.980%25 identity (35.795%25 ungapped) in 197 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family%2C NAD-binding Rossmann fold. gene gene7548 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7485 SCO7486 SCO7486 SCBAC17A6.19c SCBAC17A6.19c 8296646 8297863 - transcriptional regulator SCBAC17A6.19c%2C possible ROK-family transcriptional regulator%2C len: 405 aa%3B similar to many e.g. TR:P95610 (EMBL:X99622) regulator from Rhodococcus erythropolis (397 aa) fasta scores: opt: 548%2C Z-score: 588.4%2C 36.776%25 identity (38.220%25 ungapped) in 397 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family and Prosite match to PS01125 ROK family signature. gene gene7549 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7486 SCO7487 SCO7487 SCBAC17A6.20c SCBAC17A6.20c 8297867 8298751 - integral membrane binding protein dependent transport protein SCBAC17A6.20c%2C possible integral membrane binding protein dependent transport protein%2C len: 294aa%3B similar to many eg. TR:BAB49483 (EMBL:AP002999) permease of sugar ABC transporter from Rhizobium loti (296 aa) fasta scores: opt: 608%2C Z-score: 696.1%2C 35.570%25 identity (36.934%25 ungapped) in 298 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and multiple hydrophobic possible membrane spanning regions. gene gene7550 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7487 SCO7488 SCO7488 SCBAC17A6.21c SCBAC17A6.21c 8298748 8299779 - integral membrane binding protein dependent transport protein SCBAC17A6.21c%2C possible integral membrane binding protein dependent transport protein%2C len: 343aa%3B similar to many eg. SW:Q04698 (MALC_STRPN) maltodextrin transport permease from Streptococcus pneumoniae (435 aa) fasta scores: opt: 376%2C Z-score: 423.7%2C 26.959%25 identity (29.153%25 ungapped) in 319 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%2C Prosite match to S00402 Binding-protein-dependent transport systems inner membrane comp sign. and multiple hydrophobic possible membrane spanning regions. gene gene7551 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7488 SCO7489 SCO7489 SCBAC17A6.22c SCBAC17A6.22c 8299813 8301216 - binding protein dependent transport lipoprotein SCBAC17A6.22c%2C possible binding protein dependent transport lipoprotein%2C len: 467aa%3B weakly similar to many eg. SW:P76042 (YCJN_ECOLI) ABC transporter from Escherichia coli (430 aa) fasta scores: opt: 346%2C Z-score: 385.6%2C 26.009%25 identity (29.668%25 ungapped) in 446 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site gene gene7552 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7489 SCO7490 SCO7490 SCBAC17A6.23 SCBAC17A6.23 8301342 8302487 + oxidoreductase SCBAC17A6.23%2C possible oxidoreductase%2C len: 381aa%3B similar to many eg. TR:Q9F1Z9 (EMBL:AB033991) BtrE from Bacillus circulans (349 aa) fasta scores: opt: 710%2C Z-score: 676.3%2C 38.873%25 identity (41.071%25 ungapped) in 355 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases. N-terminus rich in pro/val/ser. gene gene7553 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7490 SCO7491 SCO7491 SCBAC17A6.24 SCBAC17A6.24 8302514 8303314 + hypothetical protein SCBAC17A6.24%2C conserved hypothetical protein%2C len: 266aa%3B similar to many eg. SW:P76044 (YCJR_ECOLI) hypothetical protein from Escherichia coli (265 aa) fasta scores: opt: 571%2C Z-score: 667.8%2C 36.502%25 identity (37.209%25 ungapped) in 263 aa overlap gene gene7554 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7491 SCO7492 SCO7492 SCBAC17A6.25 SCBAC17A6.25 8303311 8304675 + hypothetical protein SCBAC17A6.25%2C unknown%2C len: 454 aa%3B no significant database matches. gene gene7555 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7492 SCO7493 SCO7493 SCBAC17A6.26 SCBAC17A6.26 8304672 8306609 + hypothetical protein SCBAC17A6.26%2C conserved hypothetical protein%2C len: 645 aa%3B similar to many e.g. TR:Q9K6N7 (EMBL:AP001519) BH3691 protein from Bacillus halodurans (702 aa) fasta scores: opt: 1188%2C Z-score: 1277.9%2C 34.802%25 identity (37.175%25 ungapped) in 658 aa overlap gene gene7556 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7493 SCO7494 SCO7494 SCBAC17A6.27c SCBAC17A6.27c 8306615 8307055 - hypothetical protein SCBAC17A6.27c%2C possible membrane protein%2C len: 146aa%3B no significant database matches. Contains possible membrane spanning regions. gene gene7557 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7494 SCO7495 SCO7495 SCBAC17A6.28 SCBAC17A6.28 8307194 8308025 + gene gene7558 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7495 SCO7496 SCO7496 SCBAC17A6.29c SCBAC17A6.29c 8308033 8308884 - hypothetical protein SCBAC17A6.29c%2C conserved hypothetical integral membrane protein%2C len: aa%3B similar to many e.g. TR:Q9I5E8 (EMBL:AE004514) hypothetical protein from Pseudomonas aeruginosa (271 aa) fasta scores: opt: 560%2C Z-score: 552.2%2C 44.944%25 identity (48.387%25 ungapped) in 267 aa overlap. Contains multiple hydrophobic possible membrane spanning regions gene gene7559 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7496 SCO7497 SCO7497 SCBAC17A6.30 SCBAC17A6.30 8308924 8309703 + transcriptional regulator SCBAC17A6.30%2C possible transcriptional regulator%2C len: 259 aa%3B similar to many e.g. TR:Q9I5E7 (EMBL:AE004514) probable transcriptional regulator from Pseudomonas aeruginosa (262 aa) fasta scores: opt: 796%2C Z-score: 924.9%2C 48.077%25 identity in 260 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and Prosite match to PS00041 Bacterial regulatory proteins%2C araC family signature. gene gene7560 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7497 SCO7498 SCO7498 SCBAC17A6.31c SCBAC17A6.31c 8309894 8310544 - transcriptional regulator SCBAC17A6.31c%2C possible transcriptional regulator%2C len: 216 aa%3B similar to many from Streptomyces coelicolor eg. TR:O50514 (EMBL:AL009204) transcriptional regulator (231 aa) opt: 338%2C Z-score: 380.0%2C 37.321%25 identity (38.614%25 ungapped) in 209 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and Prosite match to PS00043 Bacterial regulatory proteins%2C gntR family signature. gene gene7561 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7498 SCO7499 SCO7499 SCBAC17A6.32c SCBAC17A6.32c 8310669 8311394 - racemase SCBAC17A6.32c%2C possible racemase%2C len: 241aa%3B similar to SW:Q00924 (HYUE_PSESN) hydantoin racemase from the native plasmid of Pseudomonas sp. strain NS671 (249 aa) fasta scores: opt: 564%2C Z-score: 617.1%2C 39.574%25 identity (39.744%25 ungapped) in 235 aa overlap gene gene7562 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7499 SCO7500 SCO7500 SCBAC17A6.33c SCBAC17A6.33c 8311492 8312979 - allantoin permease SCBAC17A6.33c%2C possible allantoin permease%2C len: 495aa%3B similar to many eg. SW:P75712 (ALLP_ECOLI) allantoin permease from Escherichia coli (484 aa) fasta scores: opt: 807%2C Z-score: 872.9%2C 29.622%25 identity (30.454%25 ungapped) in 476 aa overlap. Contains Pfam match to entry PF02133 Transp_cyt_pur%2C Permease for cytosine/purines%2C uracil%2C thiamine%2C allantoin and multiple hydrophobic possible membrane spanning regions. gene gene7563 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7500 SCO7501 SCO7501 SCBAC17A6.34 SCBAC17A6.34 8313196 8314671 + hydrolase SCBAC17A6.34%2C possible hydrolase%2C len: 491 aa%3B similar to many e.g. TR:P82594 (EMBL:AB023626) alpha-L-arabinofuranosidase from Streptomyces chartreusis GS901 (328 aa) fasta scores: opt: 386%2C Z-score: 429.4%2C 31.333%25 identity (33.571%25 ungapped) in 300 aa overlap. Contains a possible hydrophobic membrane spanning region gene gene7564 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7501 SCO7502 SCO7502 SCBAC17A6.35c SCBAC17A6.35c 8314675 8315715 - LacI family transcriptional regulator SCBAC17A6.35c%2C possible LacI-family transcriptional regulator%2C len: 346 aa%3B similar to many e.g. SW:P46828 (CCPA_BACME) glucose-resistance amylase regulator CcpA from Bacillus megaterium (332 aa) fasta scores: opt: 528%2C Z-score: 565.6%2C 30.769%25 identity (31.902%25 ungapped) in 338 aa overlap and TR:Q9K433 (EMBL:AL359779) LacI-family transcriptional regulator from Streptomyces coelicolor (340 aa) fasta scores: opt: 993%2C Z-score: 1055.5%2C 49.422%25 identity (51.506%25 ungapped) in 346 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family%3B Pfam match to entry PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and Prosite match to PS00356 Bacterial regulatory proteins%2C lacI family signature. gene gene7565 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7502 SCO7503 SCO7503 SCBAC17A6.36 SCBAC17A6.36 8315906 8317243 + extracellular solute-binding protein SCBAC17A6.36%2C extracellular solute-binding protein%2C len: 445aa%3B similar to many eg. TR:Q9L0B2 (EMBL:AL163003) sugar transporter sugar binding protein from Streptomyces coelicolor (452 aa) fasta scores: opt: 853%2C Z-score: 952.9%2C 37.275%25 identity (38.259%25 ungapped) in 389 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and a possible N-terminal signal sequence. gene gene7566 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7503 SCO7504 SCO7504 SCBAC17A6.37 SCBAC17A6.37 8317256 8318206 + integral membrane binding-protein-dependent transport protein SCBAC17A6.37%2C possible integral membrane binding-protein-dependent transport protein%2C len: 316aa%3B similar to many eg. TR:Q9L0B3 (EMBL:AL163003) sugar transporter integral membrane protein from Streptomyces coelicolor (313 aa) fasta scores: opt: 949%2C Z-score: 1058.2%2C 48.867%25 identity (50.671%25 ungapped) in 309 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%3B Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and multiple hydrophobic possible membrane spanning regions. gene gene7567 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7504 SCO7505 SCO7505 SCBAC17A6.38 SCBAC17A6.38 8318209 8319108 + integral membrane binding-protein-dependent transport protein SCBAC17A6.38%2C possible integral membrane binding-protein-dependent transport protein%2C len: 299aa%3B similar to many eg. TR:Q9L0B4 (EMBL:AL163003) sugar transporter integral membrane protein from Streptomyces coelicolor (313 aa) fasta scores: opt: 905%2C Z-score: 1049.4%2C 50.000%25 identity (51.799%25 ungapped) in 288 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component%3B Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and multiple hydrophobic possible membrane spanning regions. gene gene7568 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7505 SCO7506 SCO7506 SCBAC17A6.39 SCBAC17A6.39 8319174 8320994 + hydrolase SCBAC17A6.39%2C possible hydrolase%2C len: 606 aa%3B similar to many e.g. TR:Q9AHJ8 (EMBL:AF305888) beta-glucuronidase from Lactobacillus gasseri (598 aa) fasta scores: opt: 437%2C Z-score: 491.4%2C 25.054%25 identity (27.913%25 ungapped) in 459 aa overlap. Contains Pfam match to entry PF02837 Glyco_hydro_2_N%2C Glycosyl hydrolases family 2%2C sugar binding domain%3B Pfam match to entry PF00703 Glyco_hydro_2%2C Glycosyl hydrolases family 2%2C immunoglobulin-like beta-sandwich domain and Pfam match to entry PF02836 Glyco_hydro_2_C%2C Glycosyl hydrolases family 2%2C TIM barrel domain. gene gene7569 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7506 SCO7507 SCO7507 SCBAC17A6.40c SCBAC17A6.40c 8321047 8321994 - dioxygenase SCBAC17A6.40c%2C possible dioxygenase%2C len: 315 aa%3B similar to many eg. SW:P37610 (TAUD_ECOLI) alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli (282 aa) fasta scores: opt: 786%2C Z-score: 906.3%2C 44.245%25 identity (45.556%25 ungapped) in 278 aa overlap. Contains Pfam match to entry PF02668 TauD%2C Taurine catabolism dioxygenase TauD%2C TfdA family. gene gene7570 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7507 SCO7508 SCO7508 SCBAC17A6.41c SCBAC17A6.41c 8322307 8323140 - hypothetical protein SCBAC17A6.41c%2C conserved hypothetical protein%2C len: 277 aa%3B similar to many e.g. TR:AAK49792 (EMBL:AF228583) hypothetical protein from Burkholderia pseudomallei (278 aa) fasta scores: opt: 1084%2C Z-score: 1298.6%2C 55.636%25 identity (56.044%25 ungapped) in 275 aa overlap gene gene7571 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7508 SCO7509 SCO7509 SCBAC17A6.42c SCBAC17A6.42c 8323180 8324658 - hypothetical protein SCBAC25F8.01c%2C conserved hypothetical protein (fragment)%2C len: >291 aa%3B similar to TR:AAK48168 (EMBL:AE007177) Mycobacterium tuberculosis CDC1551 hypothetical 56.9 kDa protein MT3801%2C 509 aa%3B fasta scores: opt: 1078 Z-score: 1264.7 bits: 242.8 E(): 7.8e-63%3B 52.577%25 identity in 291 aa overlap and to TR:CAC32297 (EMBL:AL583943) Streptomyces coelicolor conserved hypothetical protein SC10A9.15c%2C 506 aa%3B fasta scores: opt: 1071 Z-score: 1149.0 bits: 221.3 E(): 2.8e-58%3B 54.639%25 identity in 291 aa overlap~SCBAC17A6.42c%2C conserved hypothetical protein%2C len: >234aa%3B similar to C-terminal region of TR:Q9AK89 (EMBL:AL583943) conserved hypothetical protein from Streptomyces coelicolor (505 aa) fasta scores: opt: 907%2C Z-score: 1080.6%2C 55.649%25 identity (57.826%25 ungapped) in 239 aa overlap and TR:O69666 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (509 aa) fasta scores: opt: 904%2C Z-score: 1077.0%2C 57.511%25 identity (58.772%25 ungapped) in 233 aa overlap. gene gene7572 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7509 SCO7510 SCO7510 cypH cypH 8324810 8325307 - peptidyl-prolyl cis-trans isomerase SCBAC25F8.02c%2C cypH%2C peptidyl-prolyl cis-trans isomerase%2C len: 165 aa%3B highly similar to SW:CYPH_YEAST (EMBL:X17505) Saccharomyces cerevisiae peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Cpr1 or Cyp1 or Cph1 or Scc1 or YDR155C%2C 161 aa%3B fasta scores: opt: 798 Z-score: 947.8 bits: 181.7 E(): 3.5e-45%3B 70.988%25 identity in 162 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase%2C Cyclophilin type peptidyl-prolyl cis-trans isomerase and matches to Prosite entries PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature and 2x PS00017 ATP/GTP-binding site motif A (P-loop) gene gene7573 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7510 SCO7511 SCO7511 gap2 gap2 8325357 8326355 - glyceraldehyde 3-phosphate dehydrogenase SCBAC25F8.03%2C gap2%2C glyceraldehyde 3-phosphate dehydrogenase%2C len: 332 aa%3B highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap%2C 332 aa%3B fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107%3B 88.855%25 identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c%2C 337 aa%3B fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59%3B 57.831%25 identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh%2C Glyceraldehyde 3-phosphate dehydrogenase%2C NAD binding domain and PF02800 gpdh_C%2C Glyceraldehyde 3-phosphate dehydrogenase%2C C-terminal domain and match to Prosite entry PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site gene gene7574 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7511 SCO7512 SCO7512 SCBAC25F8.04c SCBAC25F8.04c 8326492 8327448 - AraC family transcription regulator SCBAC25F8.04c%2C probable AraC-family transcriptional regulator%2C len: 318 aa%3B highly similar to TR:Q53603 (EMBL:U21191) Streptomyces aureofaciens transcriptional activator GapR%2C 278 aa%3B fasta scores: opt: 1641 Z-score: 1807.9 bits: 342.5 E(): 4.3e-93%3B 88.849%25 identity in 278 aa overlap. Contains Pfam matches to entries PF01965 ThiJ%2C ThiJ/PfpI family and PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and match to Prosite entry PS00041 Bacterial regulatory proteins%2C araC family signature. Also contains possible helix-turn-helix motif at residues 229..250 (+3.56 SD) gene gene7575 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7512 SCO7513 SCO7513 SCBAC25F8.05c SCBAC25F8.05c 8327480 8328367 - hydrolase SCBAC25F8.05c%2C possible hydrolase%2C len: 295 aa%3B similar to TR:Q9S2A5 (EMBL:AL096849) Streptomyces coelicolor hydrolase SCI11.14c%2C 268 aa%3B fasta scores: opt: 215 Z-score: 250.2 bits: 54.2 E(): 2.5e-06%3B 29.304%25 identity in 273 aa overlap. Contains Pfam match to entry PF00657 Lipase_GDSL%2C Lipase/Acylhydrolase with GDSL-like motif and possible N-terminal region signal peptide sequence gene gene7576 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7513 SCO7514 SCO7514 SCBAC25F8.06 SCBAC25F8.06 8328549 8329049 + hypothetical protein SCBAC25F8.06%2C possible integral membrane protein%2C len: 166 aa%3B similar to TR:Q9RIW7 (EMBL:AL121854) Streptomyces coelicolor transmembrane transport protein SCJ33.11%2C 163 aa%3B fasta scores: opt: 262 Z-score: 315.0 bits: 64.6 E(): 6.2e-10%3B 35.393%25 identity in 178 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7577 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7514 SCO7515 SCO7515 SCBAC25F8.07 SCBAC25F8.07 8329348 8329917 + hypothetical protein SCBAC25F8.07%2C unknown%2C len: 189 aa gene gene7578 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7515 SCO7516 SCO7516 htpG htpG 8329972 8331888 + heat shock protein 90 molecular chaperone gene gene7579 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7516 SCO7517 SCO7517 SCBAC25F8.09 SCBAC25F8.09 8332218 8333516 + hypothetical protein SCBAC25F8.09%2C possible integral membrane protein%2C len: 432 aa%3B similar to TR:Q9HTD6 (EMBL:AE004955) Pseudomonas aeruginosa hypothetical protein PA5430%2C 404 aa%3B fasta scores: opt: 1026 Z-score: 917.9 bits: 178.8 E(): 1.6e-43%3B 43.557%25 identity in 388 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7580 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7517 SCO7518 SCO7518 SCBAC25F8.10c SCBAC25F8.10c 8333583 8334140 - TetR family transcriptional regulator SCBAC25F8.10c%2C possible tetR-family transcriptional regulatory protein%2C len: 185 aa%3B similar to TR:Q9F2S8 (EMBL:AL392176) Streptomyces coelicolor tetR-family transcriptional regulatory protein SCD65.04c%2C 185 aa%3B fasta scores: opt: 501 Z-score: 575.5 bits: 113.1 E(): 1.9e-24%3B 44.134%25 identity in 179 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 30..51 (+2.59 SD) gene gene7581 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7518 SCO7519 SCO7519 SCBAC25F8.11c SCBAC25F8.11c 8334151 8334732 - sugar acetyltransferase SCBAC25F8.11c%2C probable sugar acetyltransferase%2C len: 193 aa%3B similar to SW:MAA_ECOLI (EMBL:AJ223173) Escherichia coli maltose O-acetyl transferase (EC 2.3.1.79) Maa or B0459%2C 182 aa%3B fasta scores: opt: 534 Z-score: 607.5 bits: 119.1 E(): 3.2e-26%3B 43.407%25 identity in 182 aa overlap. Contains 3x Pfam matches to entry PF00132 hexapep%2C Bacterial transferase hexapeptide (four repeats) and match to Prosite entry PS00101 Hexapeptide-repeat containing-transferases signature gene gene7582 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7519 SCO7520 SCO7520 SCBAC25F8.12c SCBAC25F8.12c 8334804 8336018 - hypothetical protein SCBAC25F8.12c%2C probable integral membrane protein%2C len: 404 aa%3B similar to SW:MOSC_RHIME (EMBL:L17071) Rhizobium meliloti membrane protein MosC%2C 407 aa%3B fasta scores: opt: 344 Z-score: 351.5 bits: 73.9 E(): 5.7e-12%3B 30.233%25 identity in 387 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7583 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7520 SCO7521 SCO7521 SCBAC25F8.13c SCBAC25F8.13c 8336087 8337202 - peptidase SCBAC25F8.13c%2C possible peptidase%2C len: 371 aa%3B similar to TR:P94288 (EMBL:D86380) Bacillus cereus alkaline D-peptidase%2C Adp%2C 388 aa%3B fasta scores: opt: 430 Z-score: 448.6 bits: 91.7 E(): 2.2e-17%3B 34.663%25 identity in 326 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7584 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7521 SCO7522 SCO7522 SCBAC25F8.14c SCBAC25F8.14c 8337389 8339560 - DNA ligase SCBAC25F8.14c%2C probable DNA ligase%2C len: 723 aa%3B similar to SW:DNLJ_ECOLI (EMBL:M30255) Escherichia coli DNA ligase (EC 6.5.1.2) LigA or Lig or DnaL or PdeC or Lop or B2411%2C 671 aa%3B fasta scores: opt: 1048 Z-score: 1091.0 bits: 212.3 E(): 3.7e-53%3B 38.394%25 identity in 685 aa overlap. Contains Pfam matches to entries PF01653 DNA_ligase_N%2C NAD-dependent DNA ligase and PF00533 BRCT%2C BRCA1 C Terminus (BRCT) domain and match to Prosite entry PS01055 NAD-dependent DNA ligase signature 1 gene gene7585 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7522 SCO7523 SCO7523 SCBAC25F8.15 SCBAC25F8.15 8339604 8342117 + chaperone SCBAC25F8.15%2C possible chaperone%2C len: 837 aa%3B highly similar to SW:CLPC_BACSU (EMBL:D26185) Bacillus subtilis negative regulator of genetic competence ClpC or MecB%2C 810 aa%3B fasta scores: opt: 2262 Z-score: 2131.8 bits: 405.4 E(): 3.9e-111%3B 50.807%25 identity in 805 aa overlap and to TR:O69936 (EMBL:AL023861) Streptomyces coelicolor Clp protease ATP binding subunit CplA or SC3C8.27c%2C 842 aa%3B fasta scores: opt: 2590 Z-score: 2440.2 bits: 462.5 E(): 2.6e-128%3B 55.952%25 identity in 840 aa overlap. Contains 2x Pfam matches to entry PF02861 Clp_N%2C Clp amino terminal domain%2C match to entry PF00004 AAA%2C ATPase family associated with various cellular activities (AAA) and matches to Prosite entries 2x PS00017 ATP/GTP-binding site motif A (P-loop%2C)%2C PS00870 Chaperonins clpA/B signature 1 and PS00871 Chaperonins clpA/B signature 2 gene gene7586 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7523 SCO7524 SCO7524 SCBAC25F8.16 SCBAC25F8.16 8342114 8342632 + hypothetical protein SCBAC25F8.16%2C conserved hypothetical protein%2C len: 172 aa%3B similar to SW:YMEL_STRLN (EMBL:X95703) Streptomyces lincolnensis hypothetical 17.2 kDa protein in melC2-rnhH intergenic region%2C 150 aa%3B fasta scores: opt: 420 Z-score: 503.1 bits: 99.3 E(): 2.1e-20%3B 40.268%25 identity in 149 aa overlap gene gene7587 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7524 SCO7525 SCO7525 SC8G12.01 SC8G12.01 8342696 8344990 + oxidoreductase SC8G12.01%2C possible oxidoreductase%2C partial CDS%2C len: >169 aa. Highly similar to several including: Streptomyces coelicolor TR:CAB52060(EMBL:AL109732) formate dehydrogenase%2C SC7H2.18 (759 aa)%2C fasta scores opt:670 z-score: 812.0 E(): 0 62.3%25 identity in 167 aa overlap and Mycobacterium tuberculosis TR:YX31_MYCTU(EMBL:Z74024) hypothetical 84.6 kd protein (779 aa)%2C fasta scores opt: 571 z-score: 692.2 E(): 4.3e-31 55.2%25 identity in 172 aa overlap.~SCBAC25F8.17%2C probable oxidoreductase (fragment)%2C len: >629 aa%3B similar to N-terminal reguion of TR:AAK47294 (EMBL:AE007119) Mycobacterium tuberculosis CDC1551 formate dehydrogenase%2C alpha subunit%2C MT2968%2C 779 aa%3B fasta scores: opt: 2423 Z-score: 2763.1 bits: 521.7 E(): 2.7e-146%3B 56.640%25 identity in 625 aa overlap and of TR:CAB52060 (EMBL:AL109732) Streptomyces coelicolor formate dehydrogenase SC7H2.18%2C 759 aa%3B fasta scores: opt: 2617 Z-score: 2803.0 bits: 529.1 E(): 2.1e-150%3B 62.798%25 identity in 629 aa overlap. Contains 2x Pfam matches to entry PF00384 molybdopterin%2C Molybdopterin oxidoreductases and match to Prosite entry PS00697 ATP-dependent DNA ligase AMP-binding site and PS00402 Binding-protein-dependent transport systems inner membrane comp sign gene gene7588 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7525 SCO7526 SCO7526 cmlR1 cmlR1 8345074 8346285 + chloramphenicol resistance protein SC8G12.02%2C cmlR1%2C chloramphenicol resistance protein%2C len: 392 aa. Highly similar to many including: Streptomyces lividans SW:CMLR_STRLI(EMBL:X59968) chloramphenicol resistance protein%2C CmlR (392 aa)%2C fasta scores opt: 940 z-score: 1039.3 E():0 40.6%25 identity in 397 aa overlap and Streptomyces violaceus TR:Q56147(EMBL:U09991) chloramphenicol resistance protein%2C CmlV (436 aa)%2C fasta scores opt: 2023 z-score: 2227.6 E():0 80.0%25 identity in 404 aa overlap. Also similar to several Streptomyces coelicolor efflux protein e.g. TR:CAB66188(EMBL:AL136500) SC1G2.16C (413 aa)%2C fasta scores opt: 1036 z-score: 1144.4 E():0 41.6%25 identity in 406 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter. Contains multiple possible membrane spanning hydrophobic domains. gene gene7589 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7526 SCO7527 SCO7527 SC8G12.03c SC8G12.03c 8346301 8347332 - DeoR family transcriptional regulator SC8G12.03c%2C possible DeoR-family transcriptional regulator%2C len: 343 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB81864 (EMBL:AL161691) DeoR-family transcriptional regulator%2C SCD40A.19C (339 aa)%2C fasta scores opt: 600 z-score: 674.6 E(): 4.1e-30 41.1%25 identity in 316 aa overlap. Contains a Prosite hit to PS00894 Bacterial regulatory proteins%2C deoR family signature with a helix-turn-helix motif situated between residues 31..52 (+2.89 SD). gene gene7590 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7527 SCO7528 SCO7528 SC8G12.04 SC8G12.04 8347357 8347857 + hypothetical protein SC8G12.04%2C unknown%2C len: 166 aa%3B similar to TR:Q9KZG9 (EMBL:AL353864) hypothetical protein SC8F11.09 from Streptomyces coelicolor (137 aa) fasta scores%3B opt: 348%2C Z-score: 421.0%2C E(): 8.2e-16%2C 38.060%25 identity (38.636%25 ungapped) in 134 aa overlap. gene gene7591 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7528 SCO7529 SCO7529 SC8G12.05 SC8G12.05 8347854 8348954 + hypothetical protein SC8G12.05%2C unknown%2C len: 366 aa. Similar to a protein of unknown function from Streptomyces coelicolor TR:Q9Z5B0(EMBL:AL035478) SC2G5.13 (368 aa)%2C fasta scores opt: 688 z-score: 727.2 E():0 44.1%25 identity in 365 aa overlap. gene gene7592 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7529 SCO7530 SCO7530 SC8G12.06c SC8G12.06c 8348997 8350079 - regulatory protein SC8G12.06c%2C possible regulatory protein%2C len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator%2C MerR family (280 aa)%2C fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3%25 identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) phosphoprotein phosphatase (509 aa)%2C fasta scores opt: 709 z-score: 790.9 E(): 0 54.6%25 identity in 238 aa overlap. Contains a Prosite hit to PS00552 Bacterial regulatory proteins%2C merR family signature and a Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family. gene gene7593 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7530 SCO7531 SCO7531 SC8G12.07c SC8G12.07c 8350151 8351407 - acyltransferase SC8G12.07c%2C integral membrane protein%2C len: 418 aa. Similar in parts to many including: Mycobacterium leprae TR:Q9ZBE3(EMBL:AL035300) acyltransferase (696 aa)%2C fasta scores opt: 294 z-score: 328.6 E(): 7.6e-11 39.5%25 identity in 443 aa overlap and Neisseria meningitidis TR:CAB85413(EMBL:AL162758) inner membrane trans-acylase (622 aa)%2C fasta scores opt: 468 z-score: 522.8 E(): 1.2e-21 31.2%25 identity in 359 aa overlap. Contains a Pfam match to entry PF01757 DUF33%2C Domain of unknown function. Also contains multiple possible membrane spanning hydrophobic domains. gene gene7594 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7531 SCO7532 SCO7532 SC8G12.08c SC8G12.08c 8351511 8352350 - hypothetical protein SC8G12.08c%2C possible hypothetical protein%2C len: 279 aa. Weakly similar to Streptomyces coelicolor TR:O69870(EMBL:AL023702) lipoprotein%2C SC1C3.28C (327 aa)%2C fasta scores 70 opt: 137 z-score: 153.5 E(): 0.43 26.0%25 identity in 269 aa overlap. Contains a possible N-terminal signal sequence. gene gene7595 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7532 SCO7533 SCO7533 SC8G12.09 SC8G12.09 8352526 8353227 + two-component system response regulator SC8G12.09%2C two-component system response regulator protein%2C len: 233 aa. Highly similar to many response regulators including: Amycolatopsis mediterranei TR:CAB82846(EMBL:AJ277082) response regulator (229 aa)%2C fasta scores opt: 937 z-score: 1114.4 E(): 0 61.9%25 identity in 231 aa overlap and Streptomyces coelicolor TR:Q9ZEP4(EMBL:AJ131213) response regulator%2C SCE94.09 (234 aa)%2C fasta scores opt: 665 z-score: 793.6 E():0 45.5%25 identity in 231 aa overlap. Contains a Pfam match to entry PF00072 response_reg%2C Response regulator receiver domain and a Pfam match to entry PF00486 trans_reg_C%2C Transcriptional regulatory protein%2C C terminal. gene gene7596 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7533 SCO7534 SCO7534 SC8G12.10 SC8G12.10 8353224 8354738 + two component system histidine kinase SC8G12.10%2C possible two component system histidine kinase%2C len: 504 aa. Highly similar to several e.g. Streptomyces coelicolor SW:AFQ2_STRCO(EMBL:D10654) sensor protein AfsQ2 (EC 2.7.3.-) (535 aa)%2C fasta scores opt: 1060 z-score: 1143.7 E(): 0 41.3%25 identity in 506 aa overlap. Contains Pfam matches to entries PF00672 DUF5%2C Domain found in bacterial signal proteins and PF00512 signal%2C Histidine kinase domain%2C as well as a possible N-terminal hydrophobic membrane spanning region gene gene7597 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7534 SCO7535 SCO7535 SC8G12.11 SC8G12.11 8354735 8355298 + lipoprotein SC8G12.11%2C possible lipoprotein%2C len: 187 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7598 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7535 SCO7536 SCO7536 SC8G12.12 SC8G12.12 8355539 8357758 + hypothetical protein SC8G12.12%2C possible integral membrane protein%2C len: 739 aa. Highly similar to many Streptomyces coelicolor membrane proteins including: TR:CAB59662(EMBL:AL132674) SCE87.17C (745 aa)%2C fasta scores opt: 1860 z-score: 1926.0 E():0 66.5%25 identity in 740 aa overlap and SW:MMLC_STRCO(EMBL:AL031107) SC5A7.16C (705 aa)%2C fasta scores opt: 596 z-score: 618.6 E(): 5.4e-27 38.7%25 identity in 744 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. gene gene7599 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7536 SCO7537 SCO7537 SC8G12.13c SC8G12.13c 8357815 8359128 - aminotransferase SC8G12.13c%2C aminotransferase%2C len: 437 aa. Highly similar to several including the bifunctional aminotransferring decarboxylase: 2%2C2-dialkylglycine decarboxylase (EC 4.1.1.64) from Burkholderia cepacia SW:DGDA_BURCE(EMBL:J05282) (432 aa)%2C fasta scores opt: 1723 z-score: 1953.5 E(): 0 63.7%25 identity in 422 aa overlap and Mycobacterium leprae SW:GABT_MYCLE(EMBL:U00011) 4-aminobutyrate aminotransferase (EC 2.6.1.19) (446 aa)%2C fasta scores opt: 697 z-score: 792.4 E(): 0 34.0%25 identity in 418 aa overlap. Contains a Prosite hit to PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site and a Pfam match to entry PF00202 aminotran_3%2C Aminotransferases class-III pyridoxal-phosphate. gene gene7600 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7537 SCO7538 SCO7538 SC8G12.14 SC8G12.14 8359215 8360183 + LysR family transcriptional regulator SC8G12.14%2C possible LysR-family transcriptional regulator%2C len: 322 aa. Similar to many regulators e.g. Escherichia coli SW:OXYR_ECOLI(EMBL:J04553) hydrogen peroxide-inducible genes activator%2C OxyR (305 aa)%2C fasta scores opt: 323 z-score: 373.2 E(): 2.5e-13 29.4%25 identity in 296 aa overlap and Streptomyces coelicolor TR:CAB71819(EMBL:AL138662) LysR-family transcriptional regulator%2C SC8E4A.14C (300 aa)%2C fasta scores opt: 488 z-score: 563.0 E(): 6.7e-24 34.0%25 identity in 288 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins%2C lysR family signature and a Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family with the helix-turn-helix motif situated between residues 24..45 (+4.98 SD). gene gene7601 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7538 SCO7539 SCO7539 SC8G12.15c SC8G12.15c 8360197 8360931 - TetR family transcriptional regulator SC8G12.15c%2C possible TetR-family transcriptional regulator%2C len: 244 aa. Similar to many e.g. Deinococcus radiodurans TR:AAF10298 (EMBL:AE001928) transcriptional regulator%2C TetR family (215 aa)%2C fasta scores opt: 187 z-score: 223.2 E(): 5.6e-05 36.5%25 identity in 104 aa overlap. Also similar to many proteins of undefined function e.g. Mycobacterium tuberculosis SW:Y0DR_MYCTU (EMBL:Z78020) hypothetical 25.4 kd protein (234 aa)%2C fasta scores opt: 372 z-score: 432.3 E(): 1.3e-16 34.1%25 identity in 229 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 42..63 (+5.38 SD). gene gene7602 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7539 SCO7540 SCO7540 SC8G12.16c SC8G12.16c 8361080 8361751 - hypothetical protein SC8G12.16c%2C hypothetical protein%2C len: 223 aa. Similar to many proteins of unknown function e.g. Streptomyces coelicolor TR:CAB53137(EMBL:AL109962) conserved hypothetical protein%2C SCJ1.19C (223 aa)%2C fasta scores: opt: 425 z-score: 510.8 E(): 5.4e-21 40.5%25 identity in 220 aa overlap. Contains 2x Pfam matches to entry PF00571 CBS%2C CBS domain gene gene7603 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7540 SCO7541 SCO7541 SC8G12.17c SC8G12.17c 8361751 8363910 - hypothetical protein SC8G12.17c%2C unknown%2C len: 719 aa. Similar to many proteins of undefined function e.g. Streptomyces coelicolor TR:CAB61192(EMBL:AL132973) hypothetical 93.0 kD protein%2C SCF91.34 (884 aa)%2C fasta scores opt: 1158 z-score: 1210.0 E():0 36.1%25 identity in 841 aa overlap. Contains a Pfam match to entry PF00989 PAS%2C PAS domain gene gene7604 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7541 SCO7542 SCO7542 SC8G12.18c SC8G12.18c 8364041 8365387 - hypothetical protein SC8G12.18c%2C possible hypothetical protein%2C len: 448 aa. Contains a possible N-terminal signal sequence. gene gene7605 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7542 SCO7543 SCO7543 SC8G12.19 SC8G12.19 8365616 8366890 + CRP family transcriptional regulator SC8G12.19%2C possible Crp-family transcriptional regulator%2C len: 424 aa. Similar to several including: Bacillus subtilis SW:XYLR_BACSU (EMBL:M27248) xylose repressor (384 aa)%2C fasta scores opt: 339 z-score: 347.1 E(): 7.1e-12 23.3%25 identity in 390 aa overlap and Streptomyces coelicolor TR:O50502 (EMBL:AL009199) probable transcriptional repressor protein%2C SC7B7.05 (403 aa)%2C fasta scores opt: 691 z-score: 697.8 E(): 2.1e-31 33.9%25 identity in 387 aa overlap. Contains a Prosite hit to PS01125 ROK family signature and Pfam hits to PF00480 ROK%2C ROK family and PF00325 crp%2C Bacterial regulatory proteins%2C crp family with the helix-turn-helix motif situated between residues 32..53 (+4.61 SD). gene gene7606 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7543 SCO7544 SCO7544 SC8G12.20 SC8G12.20 8366985 8367788 + ABC transporter membrane protein SC8G12.20%2C possible ABC-transport protein%2C membrane component%2C len: 267 aa. Similar to many other transporters e.g. Escherichia coli SW:TAUC_ECOLI(EMBL:D85613) taurine transport permease%2C TauC (275 aa)%2C fasta scores opt: 547 z-score: 643.1 E(): 2.3e-28 37.5%25 identity in 248 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. gene gene7607 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7544 SCO7545 SCO7545 SC8G12.21 SC8G12.21 8367785 8368597 + ABC transporter ATP-binding protein SC8G12.21%2C possible ABC-transport protein%2C ATP-binding component%2C len: 270 aa. Similar to multiple ABC-transport proteins e.g. Escherichia coli SW:TAUB_ECOLI(EMBL:D85613) taurine transport ATP-binding protein%2C TauB (255 aa)%2C fasta scores opt: 665 z-score: 772.8 E(): 0 43.4%25 identity in 235 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop) and a Pfam match to entry PF00005 ABC_tran%2C ABC transporter. gene gene7608 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7545 SCO7546 SCO7546 SC8G12.22 SC8G12.22 8368594 8369616 + lipoprotein SC8G12.22%2C possible solute-binding lipoprotein%2C len: 340 aa. Similar to several e.g. Escherichia coli SW:TAUA_ECOLI(EMBL:D85613) taurine-binding periplasmic protein precursor%2C TauA (320 aa)%2C fasta scores opt: 235 z-score: 267.4 E(): 1.9e-07 23.3%25 identity in 287 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene7609 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7546 SCO7547 SCO7547 SC5F1.01 SC5F1.01 8369613 8371214 + sulfatase SC5F1.01%2C possible sulfatase (fragment)%2C len: >136 aa%3B low similarity to SW:YIDJ_ECOLI (EMBL:L10328) Escherichia coli hypothetical 57.3 kDa protein in EmrD-GlvG intergenic region sulfatase YdjI (EC 3.1.6.-)%2C 497 aa%3B fasta scores: opt: 147 z-score: 185.4 E(): 0.0085%3B 29.6%25 identity in 115 aa overlap~SC8G12.23%2C possible sulphatase%2C partial CDS%2C len: >430 aa. Similar to many Eukaryotic sulphatases e.g. Homo sapiens (Human) SW:IDS_HUMAN(EMBL:M58342) iduronate 2-sulfatase precursor (EC 3.1.6.13) (550 aa)%2C fasta scores opt: 326 z-score: 382.2 E(): 7.9e-14 28.4%25 identity in 423 aa overlap. Also similar to Escherichia coli TR:YIDJ_ECOLI(EMBL:L10328) hypothetical 57.3 kd protein (497 aa)%2C fasta scores opt: 221 z-score:0.0 E(): 0.0 31.23%25 identity in 397 aa overlap. Contains a Prosite hit to PS00523 Sulfatases signature 1 and a Pfam match to entry PF00884 Sulfatase%2C Sulfatase. gene gene7610 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7547 SCO7548 SCO7548 SC5F1.02 SC5F1.02 8371292 8372236 + hypothetical protein SC5F1.02%2C conserved hypothetical protein%2C len: 314 aa%3B similar to TR:P95060 (EMBL:Z84395) Mycobacterium tuberculosis hypothetical 32.7 kDa protein MTCY210.31%2C 299 aa%3B fasta scores: opt: 704 z-score: 772.7 E(): 0%3B 47.2%25 identity in 301 aa overlap gene gene7611 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7548 SCO7549 SCO7549 SC5F1.03c SC5F1.03c 8372211 8372555 - hypothetical protein SC5F1.03c%2C hypothetical protein%2C len: 114 aa%3B similar to TR:Q9KXH9 (EMBL:AL357591) Streptomyces coelicolor hypothetical 20.1 kDa protein SCC53.32c%2C 187 aa%3B fasta scores: opt: 288 z-score: 334.7 E(): 4.1e-11%3B 46.4%25 identity in 97 aa overlap gene gene7612 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7549 SCO7550 SCO7550 SC5F1.04c SC5F1.04c 8372680 8373534 - hydrolase SC5F1.04c%2C possible hydrolase%2C len: 284 aa%3B similar to SW:GLPQ_BACSU (EMBL:Z26522) Bacillus subtilis glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) GlpQ%2C 293 aa%3B fasta scores: opt: 354 z-score: 431.1 E(): 1.7e-16%3B 27.8%25 identity in 284 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7613 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7550 SCO7551 SCO7551 SC5F1.05c SC5F1.05c 8373704 8373907 - hypothetical protein SC5F1.05c%2C hypothetical protein%2C len: 67 aa. Contains possible N-terminal region signal peptide sequence gene gene7614 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7551 SCO7552 SCO7552 SC5F1.06c SC5F1.06c 8373973 8374599 - TetR family transcriptional regulator SC5F1.06c%2C possible tetR-family transcriptional regulator%2C len: 208 aa%3B similar to many Streptomyces coelicolor tetR-family transcriptional regulators%2C e.g. TR:Q9WX19 (EMBL:AL079345) transcriptional regulator SCE68.13%2C 230 aa%3B fasta scores: opt: 567 z-score: 703.0 E(): 1.3e-31%3B 44.9%25 identity in 205 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains possible helix-turn-helix motif at residues 38..59 (+5.63 SD) gene gene7615 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7552 SCO7553 SCO7553 SC5F1.07 SC5F1.07 8374699 8375652 + oxidoreductase SC5F1.07%2C possible oxidoreductase%2C len: 317 aa%3B similar to SW:QOR_MOUSE (EMBL:S70056) Mus musculus quinone oxidoreductase (EC 1.6.5.5) CryZ%2C 331 aa%3B fasta scores: opt: 438 z-score: 441.4 E(): 4.7e-17%3B 32.8%25 identity in 335 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenases gene gene7616 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7553 SCO7554 SCO7554 SC5F1.08c SC5F1.08c 8375936 8376949 - LacI family transcriptional regulator SC5F1.08c%2C probable lacI-family transcriptional regulator%2C len: 337 aa%3B similar to TR:Q9X9R3 (EMBL:AJ009798) Streptomyces reticuli CebR protein%2C 350 aa%3B fasta scores: opt: 1152 z-score: 1278.6 E(): 0%3B 54.6%25 identity in 339 aa overlap and to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR%2C 340 aa%3B fasta scores: opt: 1031 z-score: 1145.4 E(): 0%3B 52.1%25 identity in 340 aa overlap. Also similar to TR:CAC10103 (EMBL:AL442165) Streptomyces coelicolor lacI-family transcriptional regulatory protein CebR 2SCC13.02c%2C 351 aa%3B fasta scores: opt: 1082 z-score: 996.3 E(): 0%3B 52.8%25 identity in 339 aa overlap. Contains Pfam matches to entries PF00356 lacI%2C Bacterial regulatory proteins%2C lacI family and PF00532 Peripla_BP_like%2C Periplasmic binding proteins and sugar binding domain of the LacI family. Also contains possible helix-turn-helix motif at residues 7..28 (+4.69 SD) gene gene7617 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7554 SCO7555 SCO7555 SC5F1.09 SC5F1.09 8377286 8378596 + solute binding lipoprotein SC5F1.09%2C possible solute binding lipoprotein%2C len: 436 aa%3B similar to TR:Q9L151 (EMBL:AL158061) Streptomyces coelicolor probable solute binding lipoprotein SC6D11.04c%2C 451 aa%3B fasta scores: opt: 386 z-score: 436.1 E(): 9.3e-17%3B 27.5%25 identity in 459 aa overlap. Contains Pfam match to entry PF01547 SBP_bacterial_1%2C Bacterial extracellular solute-binding protein and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal signal peptide sequence gene gene7618 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7555 SCO7556 SCO7556 SC5F1.10 SC5F1.10 8378701 8379696 + sugar transport permease SC5F1.10%2C possible sugar transport permease%2C len: 331 aa%3B similar to TR:Q9X9R6 (EMBL:AJ009797) Streptomyces reticuli CebF protein%2C 305 aa%3B fasta scores: opt: 1258 z-score: 1401.2 E(): 0%3B 57.6%25 identity in 311 aa overlap and to TR:CAC10105 (EMBL:AL442165) Streptomyces coelicolor cellobiose transport permease 2SCC13.04%2C 337 aa%3B fasta scores: opt: 1343 z-score: 1424.3 E(): 0%3B 56.5%25 identity in 336 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions gene gene7619 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7556 SCO7557 SCO7557 SC5F1.11 SC5F1.11 8379709 8380632 + sugar transport integral membrane protein SC5F1.11%2C possible sugar transport integral membrane protein%2C len: 307 aa%3B similar to TR:Q9X9R5 (EMBL:AJ009797) Streptomyces reticuli CebG protein%2C 275 aa%3B fasta scores: opt: 1165 z-score: 1331.6 E(): 0%3B 62.8%25 identity in 274 aa overlap and to TR:CAC10106 (EMBL:AL442165) Streptomyces coelicolor cellobiose transport permease 2SCC13.05%2C 303 aa%3B fasta scores: opt: 1236 z-score: 1261.9 E(): 0%3B 61.1%25 identity in 296 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions gene gene7620 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7557 SCO7558 SCO7558 SC5F1.12 SC5F1.12 8380679 8382118 + beta-glucosidase SC5F1.12%2C probable beta-glucosidase%2C len: 479 aa%3B similar to TR:Q59976 (EMBL:Z29625) Streptomyces sp. beta-glucosidase (EC 3.2.1.21) Bgl3%2C 479 aa%3B fasta scores: opt: 2961 z-score: 3301.3 E(): 0%3B 88.9%25 identity in 479 aa overlap and to TR:CAC10107 (EMBL:AL442165) Streptomyces coelicolor cellobiose hydrolase 2SCC13.06%2C 479 aa%3B fasta scores: opt: 2255 z-score: 2227.1 E(): 0%3B 67.4%25 identity in 470 aa overlap. Contains Pfam match to entry PF00232 Glyco_hydro_1%2C Glycosyl hydrolase family 1 and match to Prosite entry PS00653 Glycosyl hydrolases family 1 N-terminal signature and PS00572 Glycosyl hydrolases family 1 active site gene gene7621 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7558 SCO7559 SCO7559 SC5F1.13c SC5F1.13c 8382232 8383428 - sugar hydrolase SC5F1.13c%2C probable sugar hydrolase%2C len: 398 aa%3B similar to SW:E13B_ARTSP (EMBL:D23668) Arthrobacter sp. glucan endo-1%2C3-beta-glucosidase precursor (EC 3.2.1.39) GlcI%2C 548 aa%3B fasta scores: opt: 1570 z-score: 1670.2 E(): 0%3B 59.7%25 identity in 387 aa overlap and to Streptomyces coelicolor probable hydrolase SC5F1.30c%2C 397 aa%3B fasta scores: opt: 1795 z-score: 1707.3 E(): 0%3B 66.6%25 identity in 386 aa overlap. Contains possible N-terminal signal peptide sequence gene gene7622 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7559 SCO7560 SCO7560 SC5F1.14c SC5F1.14c 8383565 8384098 - MutT-family protein SC5F1.14c%2C possible MutT-family protein%2C len: 177 aa%3B similar to TR:AAG06157 (EMBL:AE004704) Pseudomonas aeruginosa hypothetical 14. 9 kDa protein PA2769%2C 136 aa%3B fasta scores: opt: 217 z-score: 263.8 E(): 3.6e-07%3B 39.8%25 identity in 128 aa overlap. Contains Pfam match to entry PF00293 mutT%2C Bacterial mutT protein and match to Prosite entry PS00893 mutT domain signature gene gene7623 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7560 SCO7561 SCO7561 SC5F1.15c SC5F1.15c 8384103 8385164 - esterase SC5F1.15c%2C possible esterase%2C len: 353 aa%3B similar to SW:PBP4_NOCLA (EMBL:Z13972) Nocardia lactamdurans penicillin-binding protein 4 Pbp-4%2C 381 aa%3B fasta scores: opt: 246 z-score: 283.9 E(): 2.8e-08%3B 30.6%25 identity in 301 aa overlap gene gene7624 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7561 SCO7562 SCO7562 SC5F1.16c SC5F1.16c 8385161 8385997 - transcriptional regulator SC5F1.16c%2C probable transcriptional regulator%2C len: 278 aa%3B similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR%2C 274 aa%3B fasta scores: opt: 353 z-score: 395.0 E(): 1.8e-14%3B 30.0%25 identity in 243 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator. Also contains possible helix-turn-helix motif at residues 36..57 (+6.31 SD) gene gene7625 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7562 SCO7563 SCO7563 SC5F1.17 SC5F1.17 8386079 8387629 + ABC transporter solute binding lipoprotein gene gene7626 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7563 SCO7564 SCO7564 SC5F1.18 SC5F1.18 8387626 8388618 + oligopeptide ABC transporter integral membrane protein gene gene7627 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7564 SCO7565 SCO7565 SC5F1.19 SC5F1.19 8388624 8389529 + oligopeptide ABC transporter integral membrane protein gene gene7628 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7565 SCO7566 SCO7566 SC5F1.20 SC5F1.20 8389526 8390392 + oligopeptide ABC transporter ATP-binding protein gene gene7629 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7566 SCO7567 SCO7567 SC5F1.21 SC5F1.21 8390389 8391339 + oligopeptide ABC transporter ATP-binding protein SC5F1.21%2C probable oligopeptide ABC transporter ATP-binding protein%2C len: 316 aa%3B similar to SW:OPPF_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport ATP-binding protein OppF%2C 308 aa%3B fasta scores: opt: 811 z-score: 836.7 E(): 0%3B 46.9%25 identity in 273 aa overlap. Contains Pfam match to entry PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature gene gene7630 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7567 SCO7568 SCO7568 SC5F1.22c SC5F1.22c 8391351 8392310 - regulatory protein SC5F1.22c%2C possible regulatory protein%2C len: 319 aa%3B similar to TR:O50502 (EMBL:AL009199) Streptomyces coelicolor probable transcriptional repressor protein SC7B7.05%2C 403 aa%3B fasta scores: opt: 377 z-score: 404.3 E(): 5.5e-15%3B 29.3%25 identity in 290 aa overlap. Contains Pfam match to entry PF00480 ROK%2C ROK family gene gene7631 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7568 SCO7569 SCO7569 SC5F1.23 SC5F1.23 8392352 8393143 + hypothetical protein SC5F1.23%2C conserved hypothetical protein%2C len: 263 aa%3B similar to TR:P74740 (EMBL:D90917) Synechocystis sp. hypothetical 30.2 kDa protein SLR0596%2C 273 aa%3B fasta scores: opt: 248 z-score: 279.7 E(): 4.7e-08%3B 31.6%25 identity in 266 aa overlap gene gene7632 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7569 SCO7570 SCO7570 SC5F1.24 SC5F1.24 8393167 8394294 + isomerase SC5F1.24%2C probable isomerase%2C len: 375 aa%3B similar to SW:GUDH_STRCO (EMBL:AL136503) Streptomyces coelicolor probable glucarate dehydratase (EC 4.2.1.40) GudD or SCC77.09c%2C 431 aa%3B fasta scores: opt: 553 z-score: 623.1 E(): 3.6e-27%3B 37.2%25 identity in 398 aa overlap and to SW:TFDD_ALCEU (EMBL:M35097) Alcaligenes eutrophu chloromuconate cycloisomerase (EC 5.5.1.7) TfdD%2C 370 aa%3B fasta scores: opt: 419 z-score: 474.3 E(): 7e-19%3B 29.1%25 identity in 385 aa overlap. Contains Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family. Contains possible hydrophobic membrane spanning region gene gene7633 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7570 SCO7571 SCO7571 SC5F1.25 SC5F1.25 8394291 8394704 + hypothetical protein SC5F1.25%2C conserved hypothetical protein%2C len: 137 aa%3B similar to SW:Y854_PYRHO (EMBL:AP000003) Pyrococcus horikoshii hypothetical protein PH0854%2C 137 aa%3B fasta scores: opt: 326 z-score: 392.0 E(): 2.7e-14%3B 44.3%25 identity in 122 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C Domain of unknown function UPF0076 gene gene7634 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7571 SCO7572 SCO7572 SC5F1.26 SC5F1.26 8394796 8397792 + oxidoreductase SC5F1.26%2C possible oxidoreductase%2C len: 998 aa%3B similar to TR:Q9KKW5 (EMBL:AE004425) Vibrio cholerae oxidoreductase/iron-sulfur cluster-binding protein VCA0985%2C 959 aa%3B fasta scores: opt: 1999 z-score: 2189.0 E(): 0%3B 35.3%25 identity in 966 aa overlap. Contains Pfam matches to entries PF01565 FAD_binding_4%2C FAD binding domain and PF00037 fer4%2C 4Fe-4S binding domain and matches to Prosite entries PS00422 Granins signature 1 and PS00198 4Fe-4S ferredoxins%2C iron-sulfur binding region signature gene gene7635 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7572 SCO7573 SCO7573 SC5F1.27c SC5F1.27c 8397789 8398133 - anti-sigma factor antagonist SC5F1.27c%2C probable anti-sigma factor antagonist%2C len: 114 aa%3B similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG%2C 113 aa%3B fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17%3B 49.5%25 identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS%2C STAS domain gene gene7636 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7573 SCO7574 SCO7574 SC5F1.28 SC5F1.28 8398334 8398483 + hypothetical protein SC5F1.28%2C membrane protein%2C len: 49 aa. Contains possible hydrophobic membrane spanning region gene gene7637 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7574 SCO7575 SCO7575 SC5F1.29c SC5F1.29c 8398566 8399423 - hydrolase SC5F1.29c%2C probable hydrolase%2C len: 285 aa%3B similar to SW:GUB_RHOMR (EMBL:U04836) Rhodothermus marinus beta-glucanase precursor (EC 3.2.1.73) BglA%2C 286 aa%3B fasta scores: opt: 626 z-score: 709.7 E(): 5.3e-32%3B 40.5%25 identity in 296 aa overlap and to N-terminal region of TR:CAC14352 (EMBL:AL445945) Streptomyces coelicolor hydrolase 3SCF60.19%2C 422 aa%3B fasta scores: opt: 1508 z-score: 1618.5 E(): 0%3B 75.9%25 identity in 299 aa overlap. Contains Pfam match to entry PF00722 Glyco_hydro_16%2C Glycosyl hydrolases family 16 and match to Prosite entry PS01034 Glycosyl hydrolases family 16 active sites. Also contains possible N-terminal region signal peptide sequence gene gene7638 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7575 SCO7576 SCO7576 SC5F1.30c SC5F1.30c 8399524 8400717 - hydrolase SC5F1.30c%2C probable hydrolase%2C len: 397 aa%3B highly similar to TR:Q9Z4I2 (EMBL:AB019428) Streptomyces matensis laminaripentaose-producing beta-1%2C3-guluase (LPHase) precursor LPH%2C 401 aa%3B fasta scores: opt: 1827 z-score: 1870.8 E(): 0%3B 65.0%25 identity in 394 aa overlap and to Streptomyces coelicolor SC5F1.13c%2C 398 aa%3B fasta scores: opt: 1795 z-score: 1665.4 E(): 0%3B 66.6%25 identity in 386 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7639 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7576 SCO7577 SCO7577 SC5F1.31 SC5F1.31 8400971 8402080 + hydrolase SC5F1.31%2C possible hydrolase%2C len: 369 aa%3B similar to TR:P82594 (EMBL:AB023626) Streptomyces chartreusis alpha-L-arabinofuranosidase II precursor (EC 3.2.1.55)%2C 328 aa%3B fasta scores: opt: 336 z-score: 382.3 E(): 9.2e-14%3B 27.8%25 identity in 302 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7640 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7577 SCO7578 SCO7578 SC5F1.32c SC5F1.32c 8402124 8402741 - hypothetical protein SC5F1.32c%2C unknown%2C len: 205 aa gene gene7641 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7578 SCO7579 SCO7579 SC5F1.33 SC5F1.33 8402873 8403748 + DNA-binding protein SC5F1.33%2C possible DNA-binding protein%2C len: 291 aa%3B similar to TR:Q9KZY5 (EMBL:AL353815) Streptomyces coelicolor DNA-binding protein SCD6.19%2C 295 aa%3B fasta scores: opt: 643 z-score: 787.2 E(): 0%3B 37.0%25 identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. Also contains possible helix-turn-helix motif at residues 31..52 (+6.28 SD) gene gene7642 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7579 SCO7580 SCO7580 SC5F1.34 SC5F1.34 8403793 8404608 + hypothetical protein SC5F1.34%2C hypothetical protein%2C len: 271 aa%3B similar to many Streptomyces coelicolor hypothetical proteins%2C e.g. TR:Q9WX26 (EMBL:AL079345) hypothetical 33.1 kDa protein SCE68.05c%2C 300 aa%3B fasta scores: opt: 794 z-score: 946.3 E(): 0%3B 51.6%25 identity in 248 aa overlap gene gene7643 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7580 SCO7581 SCO7581 SC5F1.35c SC5F1.35c 8404672 8406342 - hypothetical protein SC5F1.35c%2C hypothetical protein%2C len: 556 aa%3B low similarity to SW:Y811_METJA (EMBL:U67525) Methanococcus jannaschii hypothetical protein MJ0811%2C 439 aa%3B fasta scores: opt: 321 z-score: 347.7 E(): 7.7e-12 26.8%25 identity in 287 aa overlap gene gene7644 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7581 SCO7582 SCO7582 SC5F1.36c SC5F1.36c 8406363 8407580 - hypothetical protein SC5F1.36c%2C hypothetical protein%2C len: 405 aa%3B low similarity to SW:Y812_METJA (EMBL:U67525) Methanococcus jannaschii hypothetical protein MJ0812%2C 373 aa%3B fasta scores: opt: 567 z-score: 644.6 E(): 2.2e-28%3B 33.1%25 identity in 311 aa overlap gene gene7645 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7582 SCO7583 SCO7583 SC5F1.37 SC5F1.37 8407690 8409591 + hydrolase SC5F1.37%2C possible hydrolase%2C len: 633 aa%3B similar to SW:GUN1_STRRE (EMBL:X65616) Streptomyces reticuli cellulase 1 precursor (EC 3.2.1.4) Cel1%2C 746 aa%3B fasta scores: opt: 270 z-score: 294.7 E(): 7e-09%3B 26.0%25 identity in 623 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7646 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7583 SCO7584 SCO7584 SC5F1.38c SC5F1.38c 8409626 8410198 - transcriptional regulator SC5F1.38c%2C probable transcriptional regulator%2C len: 190 aa%3B low similarity to SW:TER4_ECOLI (EMBL:X01083) Escherichia coli tetracycline repressor protein class D TetR%2C 217 aa%3B fasta scores: opt: 131 z-score: 169.5 E(): 0.066%3B 33.0%25 identity in 100 aa overlap. Contains possible helix-turn-helix motif at residues 27..48 (+4.31 SD) gene gene7647 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7584 SCO7585 SCO7585 SC5F1.39c SC5F1.39c 8410259 8410657 - MerR family transcriptional regulator SC5F1.39c%2C probable merR-family transcriptional regulator%2C len: 132 aa%3B similar to SW:SOXR_PSEAE (EMBL:X95517) Pseudomonas aeruginosa SoxR protein%2C 156 aa%3B fasta scores: opt: 205 z-score: 264.7 E(): 3.3e-07%3B 36.8%25 identity in 117 aa overlap. Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and match to Prosite entry PS00552 Bacterial regulatory proteins%2C merR family signature and possible helix-turn-helix at residues 12..33 (+4.37 SD) gene gene7648 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7585 SCO7586 SCO7586 SC5F1.40 SC5F1.40 8410741 8411814 + oxidoreductase SC5F1.40%2C probable oxidoreductase%2C len: 357 aa%3B similar to SW:NEMA_ECOLI (EMBL:D86931) Escherichia coli N-ethylmaleimide reductase (EC 1.-.-.-) NemA%2C 365 aa%3B fasta scores: opt: 830 z-score: 878.8 E(): 0%3B 40.5%25 identity in 365 aa overlap. Contains Pfam match to entry PF00724 oxidored_FMN%2C NADH:flavin oxidoreductase / NADH oxidase family gene gene7649 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7586 SCO7587 SCO7587 SC5F1.41 SC5F1.41 8411919 8413286 + hypothetical protein SC5F1.41%2C possible integral membrane protein%2C len: 455 aa%3B similar to TR:Q9L0X9 (EMBL:AL159178) Streptomyces coelicolor membrane protein SCH22A.03c%2C 429 aa%3B fasta scores: opt: 1974 z-score: 2163.7 E(): 0%3B 69.7%25 identity in 423 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7650 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7587 SCO7588 SCO7588 SC5F1.42c SC5F1.42c 8413357 8414277 - oxidoreductase SC5F1.42c%2C possible oxidoreductase%2C len: 306 aa%3B similar to various Streptomyces coelicolor oxidoreductases/dehydrogenases%2C e.g. TR:Q9RIU1 (EMBL:AL133278) dehydratase SCM11.21c%2C 319 aa%3B fasta scores: opt: 912 z-score: 984.0 E(): 0%3B 47.4%25 identity in 312 aa overlap gene gene7651 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7588 SCO7589 SCO7589 SC5F1.43c SC5F1.43c 8414425 8415273 - hypothetical protein SC7H9.01c%2C unknown (fragment)%2C len: >158~SC5F1.43c%2C unknown (fragment)%2C len: >161 aa gene gene7652 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7589 SCO7590 SCO7590 katA2 katA2 8415439 8416959 - catalase SC7H9.02c%2C katA2%2C catalase%2C len: 487 aa%3B similar to SW:CATA_MICLU (PIR:S27264) Micrococcus luteus catalase (EC 1.11.1.6) KatA%2C 497 aa%3B fasta scores: opt: 1791 z-score: 2040.9 E(): 0%3B 54.8%25 identity in 484 aa overlap and to SW:CATA_STRCO (EMBL:AL035478) Streptomyces coelicolor catalase KatA or SC2G5.25c%2C 487 aa%3B fasta scores: opt: 1699 z-score: 1936.3 E(): 0%3B 53.8%25 identity in 483 aa overlap. Contains Pfam match to entry PF00199 catalase%2C Catalase and matches to Prosite entries PS00438 Catalase proximal active site signature and PS00437 Catalase proximal heme-ligand signature gene gene7653 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7590 SCO7591 SCO7591 SC7H9.03c SC7H9.03c 8417434 8418396 - regulatory protein SC7H9.03c%2C probable regulatory protein%2C len: 320 aa%3B similar to SW:NAHR_PSEPU (EMBL:J04233) Pseudomonas putida transcriptional activator protein NahR%2C 300 aa%3B fasta scores: opt: 452 z-score: 510.2 E(): 7e-21%3B 32.4%25 identity in 296 aa overlap. Contains Pfam matches to entries PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and PF01046 NodD_C_term%2C NodD transcription activator carboxyl terminal region and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature gene gene7654 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7591 SCO7592 SCO7592 SC7H9.04 SC7H9.04 8418509 8419402 + hypothetical protein SC7H9.04%2C hypothetical protein%2C len: 297 aa%3B similar to TR:Q9RCY4 (EMBL:AL133469) Streptomyces coelicolor hypothetical 31.4 kDa protein SCM10.14c%2C 299 aa%3B fasta scores: opt: 791 z-score: 890.7 E(): 0%3B 46.4%25 identity in 302 aa overlap gene gene7655 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7592 SCO7593 SCO7593 SC7H9.05 SC7H9.05 8419486 8419851 + hypothetical protein SC7H9.05%2C unknown%2C len: 121 aa gene gene7656 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7593 SCO7594 SCO7594 SC7H9.06 SC7H9.06 8420016 8421062 + oxidoreductase SC7H9.06%2C possible oxidoreductase%2C len: 348 aa%3B highly similar to TR:Q46851 (EMBL:U28377) Escherichia coli reductase ORF_0346%2C 346 aa%3B fasta scores: opt: 1411 z-score: 1623.6 E(): 0%3B 61.9%25 identity in 344 aa overlap%2C to TR:Q39151 (EMBL:L40948) Arabidopsis thaliana K+ channel protein beta subunit%2C 328 aa%3B fasta scores: opt: 639 z-score: 738.9 E(): 0%3B 38.9%25 identity in 306 aa overlap and to TR:CAB42946 (EMBL:AL049863) Streptomyces coelicolor ion channel subunit SC5H1.21%2C 319 aa%3B fasta scores: opt: 1347 z-score: 1354.1 E(): 0%3B 64.9%25 identity in 322 aa overlap. Contains 2x Pfam matches to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene7657 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7594 SCO7595 SCO7595 anmK anmK 8421086 8422261 - anhydro-N-acetylmuramic acid kinase catalyzes hydrolysis of 1%2C6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate%3B involved in murein recycling gene gene7658 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7595 SCO7596 SCO7596 SC7H9.08c SC7H9.08c 8422299 8423870 - integral membrane transport protein SC7H9.08c%2C probable integral membrane transport protein%2C len: 523 aa%3B similar to SW:SGLT_VIBPA (EMBL:D78137) Vibrio parahaemolyticus sodium/glucose co-transporter (Na(+)/glucose symporter) SglT%2C 543 aa%3B fasta scores: opt: 445 z-score: 513.1 E(): 4.8e-21%3B 24.4%25 identity in 471 aa overlap. Contains Pfam match to entry PF00474 SSF%2C Sodium:solute symporter family. Also contains possible hydrophobic membrane spanning regions gene gene7659 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7596 SCO7597 SCO7597 SC7H9.09c SC7H9.09c 8423879 8424877 - hypothetical protein SC7H9.09c%2C hypothetical protein%2C len: 332 aa%3B similar to TR:Q9EX11 (EMBL:AL445503) Streptomyces coelicolor hypothetical 33.0 kDa protein 2SCG38.08%2C 332 aa%3B fasta scores: opt: 619 z-score: 588.5 E(): 3e-25%3B 45.3%25 identity in 329 aa overlap. High content in alanine amino acid residues gene gene7660 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7597 SCO7598 SCO7598 SC7H9.10 SC7H9.10 8424898 8425014 + hypothetical protein SC7H9.10%2C unknown%2C len: 38 aa. Doubtful CDS%2C low content in G+C (63.15%25) gene gene7661 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7598 SCO7599 SCO7599 SC7H9.11 SC7H9.11 8425073 8426008 + transcriptional regulator SC7H9.11%2C probable transcriptional regulator%2C len: 311 aa%3B similar to SW:HEXR_ECOLI (EMBL:AE000279) Escherichia coli Hex regulon repressor HexR%2C 289 aa%3B fasta scores: opt: 428 z-score: 486.6 E(): 1.4e-19%3B 31.9%25 identity in 285 aa overlap. Contains Pfam match to entry PF01418 HTH_6%2C Helix-turn-helix domain%2C rpiR family and PF01380 SIS%2C SIS domain. Also contains possible helix-turn-helix motif at residues 54..75 (+3.19 SD) gene gene7662 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7599 SCO7600 SCO7600 SC7H9.12c SC7H9.12c 8426016 8427230 - alanyl tRNA synthetase SC7H9.12c%2C possible alanyl tRNA synthetase%2C len: 404 aa%3B similar to N-terminal region of SW:SYA_THIFE (EMBL:X95571) Thiobacillus ferrooxidans alanyl-tRNA-synthetase (EC 6.1.1.7) AlaS%2C 877 aa%3B fasta scores: opt: 728 z-score: 825.4 E(): 0%3B 37.4%25 identity in 425 aa overlap. Contains Pfam match to entry PF01411 tRNA-synt_2c%2C tRNA synthetases class II (A) and matches to Prosite entries PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 and PS00017 ATP/GTP-binding site motif A (P-loop) gene gene7663 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7600 SCO7601 SCO7601 SC7H9.13c SC7H9.13c 8427526 8428998 - amidase SC7H9.13c%2C probable amidase%2C len: 490 aa%3B similar to TR:Q9LCX3 (EMBL:AF202447) Thermus aquaticus Glu/Asp-tRNA amidotransferase subunit A%2C GatA%2C 471 aa%3B fasta scores: opt: 614 z-score: 609.3 E(): 2.1e-26%3B 34.7%25 identity in 470 aa overlap. Contains Pfam match to entry PF01425 Amidase%2C Amidase and match to Prosite entry PS00571 Amidases signature gene gene7664 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7601 SCO7602 SCO7602 SC7H9.14 SC7H9.14 8429126 8429713 + TetR family transcriptional regulator SC7H9.14%2C probable tetR-family transcriptional regulator%2C len: 195 aa%3B similar to TR:O53323 (EMBL:AL021646) Mycobacterium tuberculosis regulatory protein MTV014.17c%2C 200 aa%3B fasta scores: opt: 319 z-score: 395.7 E(): 1.7e-14%3B 33.3%25 identity in 195 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. Also contains possible helix-turn-helix motif at residues 36..57 (+3.70 SD) gene gene7665 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7602 SCO7603 SCO7603 SC2H2.01c SC2H2.01c 8429821 8430771 - LysR family transcriptional regulator SC2H2.01c%2C probable lysR-family transcriptional regulator (fragment)%2C len: >162 aa%3B similar to N-terminal domain of SW:TFDR_ALCEU (EMBL:M98445) Alcaligenes eutrophus transcriptional regulatory protein TdfR/TdfS%2C 295 aa%3B fasta scores: opt: 240 z-score: 294.4 E(): 7.3e-09%3B 37.2%25 identity in 145 aa overlap and of TR:CAB55524 (EMBL:AL117322) Streptomyces coelicolor LysR-family transcriptional regulator SCF1.04%2C 311 aa%3B fasta scores: opt: 461 z-score: 473.3 E(): 1.1e-20%3B 51.0%25 identity in 153 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and match to Prosite entry PS00044 Bacterial regulatory proteins%2C lysR family signature. Also contains possible helix-turn-helix motif at residues 24..45 (+4.95 SD)~SC7H9.15c%2C possible regulatory protein (fragment)%2C len: >187 aa%3B similar to TR:O88132 (EMBL:AJ006517) Streptomyces lipmanii lysR-type transcriptional regulator StgR%2C 327 aa%3B fasta scores: opt: 253 z-score: 307.5 E(): 1.4e-09%3B 30.5%25 identity in 187 aa overlap gene gene7666 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7603 SCO7604 SCO7604 SC2H2.02 SC2H2.02 8430895 8431779 + hypothetical protein SC2H2.02%2C hypothetical protein%2C len: 294 aa%3B similar to TR:Q9S1Z5 (EMBL:AL109747) Streptomyces coelicolor hypothetical protein SCJ21.12c%2C 279 aa%3B fasta scores: opt: 321 z-score: 379.2 E(): 1.4e-13%3B 33.1%25 identity in 278 aa overlap gene gene7667 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7604 SCO7605 SCO7605 SC2H2.03c SC2H2.03c 8431787 8433208 - metallopeptidase SC2H2.03c%2C possible metallopeptidase%2C len: 473 aa%3B low similarity to TR:Q9X7P2 (EMBL:AL049587) Streptomyces coelicolor metallopeptidase SC5F2A.19c%2C 506 aa%3B fasta scores: opt: 226 z-score: 242.7 E(): 5.5e-06%3B 23.7%25 identity in 363 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1%2C Peptidase family M1 and match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Contains possible hydrophobic membrane spanning region gene gene7668 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7605 SCO7606 SCO7606 SC2H2.04 SC2H2.04 8433408 8434529 + amino acid binding protein SC2H2.04%2C possible amino acid binding protein%2C len: 373 aa%3B low similarity to TR:O68027 (EMBL:AF010496) Rhodobacter capsulatus potential Leu/Ile/Val-binding protein precursor%2C 400 aa%3B fasta scores: opt: 226 z-score: 253.4 E(): 1.4e-06%3B 25.2%25 identity in 322 aa overlap gene gene7669 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7606 SCO7607 SCO7607 SC2H2.05c SC2H2.05c 8434553 8435734 - hydrolase SC2H2.05c%2C possible hydrolase%2C len: 393 aa%3B similar to SW:DAC_STRSQ (EMBL:M26842) Streptomyces sp. D-alanyl-D-alanine carboxypeptidase precursor (EC 3.4.16.4)%2C 372 aa%3B fasta scores: opt: 313 z-score: 344.0 E(): 1.3e-11%3B 33.8%25 identity in 364 aa overlap gene gene7670 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7607 SCO7608 SCO7608 SC2H2.06 SC2H2.06 8435801 8436253 + hypothetical protein SC2H2.06%2C hypothetical protein%2C len: 150 aa%3B similar to TR:Q9L0J1 (EMBL:AL161691) Streptomyces coelicolor hypothetical 15.7 kDa protein SCD40A.20%2C 145 aa%3B fasta scores: opt: 335 z-score: 414.8 E(): 1.4e-15%3B 45.0%25 identity in 120 aa overlap gene gene7671 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7608 SCO7609 SCO7609 SC2H2.07c SC2H2.07c 8436288 8436974 - esterase SC2H2.07c%2C possible esterase%2C len: 228 aa%3B low similarity to TR:Q9K3V2 (EMBL:AL359988) Streptomyces coelicolor esterase SCD10.24%2C 241 aa%3B fasta scores: opt: 169 z-score: 195.6 E(): 0.0023%3B 28.0%25 identity in 236 aa overlap gene gene7672 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7609 SCO7610 SCO7610 SC2H2.08 SC2H2.08 8437174 8438154 + transcriptional regulator SC2H2.08%2C possible transcriptional regulator%2C len: 371 aa%3B similar to many other Streptomyces coelicolor transcriptional regulators%2C e.g. TR:Q9KYU5 (EMBL:AL355832) DeoR-family transcriptional regulator SCE22.17%2C 323 aa%3B fasta scores: opt: 458 z-score: 518.3 E(): 2.4e-21%3B 32.3%25 identity in 319 aa overlap. Contains possible helix-turn-helix motif at residues 24..45 (+3.61 SD) gene gene7673 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7610 SCO7611 SCO7611 SC2H2.09 SC2H2.09 8438157 8438870 + hypothetical protein SC2H2.09%2C conserved hypothetical protein%2C len: 237 aa%3B similar to TR:O06738 (EMBL:Y09476) Bacillus subtilis YitC protein%2C 228 aa%3B fasta scores: opt: 320 z-score: 384.6 E(): 6.9e-14%3B 32.2%25 identity in 199 aa overlap gene gene7674 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7611 SCO7612 SCO7612 SC2H2.10c SC2H2.10c 8438874 8439524 - hypothetical protein SC2H2.10c%2C hypothetical protein%2C len: 216 aa%3B similar to TR:O86515 (EMBL:AL031124) Streptomyces coelicolor hypothetical 20.0 kDa protein SC1C2.14c%2C 185 aa%3B fasta scores: opt: 633 z-score: 752.2 E(): 0%3B 50.0%25 identity in 184 aa overlap gene gene7675 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7612 SCO7613 SCO7613 SC2H2.11c SC2H2.11c 8439704 8442160 - hypothetical protein SC2H2.11c%2C possible integral membrane protein%2C len: 818 aa. Contains possible hydrophobic membrane spanning regions and 4x degenerate repeat unit: SRTGG gene gene7676 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7613 SCO7614 SCO7614 SC2H2.12c SC2H2.12c 8442244 8442765 - regulatory protein SC2H2.12c%2C possible regulatory protein%2C len: 173 aa%3B similar to TR:Q9L1E5 (EMBL:AL157916) Streptomyces coelicolor AbaA-like regulatory protein SC3D11.17%2C 220 aa%3B fasta scores: opt: 232 z-score: 287.6 E(): 1.8e-08%3B 41.1%25 identity in 129 aa overlap. Contains TTA leucine codon (37) possible target for bldA regulation gene gene7677 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7614 SCO7615 SCO7615 SC2H2.13 SC2H2.13 8442864 8443736 + DNA-binding protein SC2H2.13%2C possible DNA-binding protein%2C len: 290 aa%3B similar to many Streptomyces coelicolor DNA-binding proteins%2C e.g. TR:CAC01466 (EMBL:AL391014) DNA-binding protein 2SCG1.17%2C 286 aa%3B fasta scores: opt: 613 z-score: 722.6 E(): 1e-32%3B 41.8%25 identity in 261 aa overlap and TR:CAA20634 (EMBL:AL031515) hypothetical protein SC5C7.22c%2C 287 aa%3B fasta scores: opt: 917 z-score: 1027.9 E(): 0%3B 50.0%25 identity in 292 aa overlap. Contains possible helix-turn-helix motif at residues 33..54 (+4.70 SD) gene gene7678 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7615 SCO7616 SCO7616 SC2H2.14 SC2H2.14 8443733 8444002 + AbaA-like protein SC2H2.14%2C possible AbaA-like protein%2C len: 89 aa%3B similar to TR:Q53896 (EMBL:X60316) Streptomyces coelicolor regulator AbaA or SCF42.13%2C 75 aa%3B fasta scores: opt: 209 z-score: 274.1 E(): 9.8e-08%3B 47.3%25 identity in 74 aa overlap gene gene7679 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7616 SCO7617 SCO7617 SC2H2.15 SC2H2.15 8443999 8444814 + hypothetical protein SC2H2.15%2C hypothetical protein%2C len: 271 aa%3B similar to many Streptomyces coelicolor hypothetical proteins%2C e.g. TR:O86718 (EMBL:AL031515) hypothetical 29.3 kDa protein SC5C7.21c%2C 271 aa%3B fasta scores: opt: 863 z-score: 1030.6 E(): 0%3B 51.5%25 identity in 274 aa overlap gene gene7680 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7617 SCO7618 SCO7618 SC2H2.16 SC2H2.16 8444820 8445614 + transcriptional regulator SC2H2.16%2C probable transcriptional regulator%2C len: 264 aa%3B similar to SW:GYLR_STRGR (EMBL:M37327) Streptomyces griseus glycerol operon regulatory protein GylR%2C 254 aa%3B fasta scores: opt: 270 z-score: 322.5 E(): 2e-10%3B 34.0%25 identity in 253 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator and possible helix-turn-helix motif at residues 42..63 (+3.28 SD) gene gene7681 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7618 SCO7619 SCO7619 SC2H2.17 SC2H2.17 8445701 8446105 + anti sigma factor antagonist SC2H2.17%2C probable anti sigma factor antagonist%2C len: 134 aa%3B similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist RsvB or BldG or SCH5.12c%2C 113 aa%3B fasta scores: opt: 263 z-score: 348.2 E(): 7.3e-12%3B 41.2%25 identity in 97 aa overlap. Contains Pfam match to entry PF01740 STAS%2C STAS domain gene gene7682 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7619 SCO7620 SCO7620 SC2H2.18 SC2H2.18 8446200 8446559 + hypothetical protein SC2H2.18%2C hypothetical protein%2C len: 119 aa%3B similar to TR:Q9K4K9 (EMBL:AL357613) Streptomyces coelicolor hypothetical 13.1 kDa protein SC5F8.15c%2C 117 aa%3B fasta scores: opt: 382 z-score: 486.2 E(): 1.5e-19%3B 53.0%25 identity in 117 aa overlap gene gene7683 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7620 SCO7621 SCO7621 SC2H2.19 SC2H2.19 8446701 8447144 + hypothetical protein SC2H2.19%2C conserved hypothetical protein%2C len: 147 aa%3B low similarity to TR:AAG05206 (EMBL:AE004608) Pseudomonas aeruginosa hypothetical 14.4 kDa protein PA1817%2C 129 aa%3B fasta scores: opt: 142 z-score: 193.7 E(): 0.0029%3B 30.5%25 identity in 131 aa overlap gene gene7684 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7621 SCO7622 SCO7622 pntB pntB 8447193 8448644 - NAD(P) transhydrogenase subunit beta SC2H2.20c%2C pntB%2C NAD(P) transhydrogenase beta subunit%2C len: 483 aa%3B similar to SW:PNTB_ECOLI (EMBL:X04195) Escherichia coli NAD(P) transhydrogenase subunit beta (EC 1.6.1.1) PntB%2C 462 aa%3B fasta scores: opt: 2012 z-score: 2208.6 E(): 0%3B 68.8%25 identity in 464 aa overlap. Contains Pfam match to entry PF02233 PNTB%2C NAD(P) transhydrogenase beta subunit. Also contains possible hydrophobic membrane spanning regions gene gene7685 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7622 SCO7623 SCO7623 pntA pntA 8448650 8450224 - NAD(P) transhydrogenase subunit alpha forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane%3B involved in catalyzing transfer of hydride ion equivalents between NAD and NADP%3B stereospecific (AB-specific)%3B functions as a proton pump by translocating protons from cytoplasm to periplasm gene gene7686 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7623 SCO7624 SCO7624 SC2H2.22c SC2H2.22c 8450331 8451026 - TetR family transcriptional regulator SC2H2.22c%2C possible tetR-family regulatory protein%2C len: 231 aa%3B similar to many other tetR-family transcriptional regulators%2C e.g. TR:CAC08314 (EMBL:AL392149) Streptomyces coelicolor tetR-family transcriptional regulatory protein SCD19.13c%2C 268 aa%3B fasta scores: opt: 456 z-score: 539.8 E(): 1.6e-22%3B 38.4%25 identity in 232 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family gene gene7687 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7624 SCO7625 SCO7625 SC2H2.23 SC2H2.23 8451080 8452201 + monooxygenase SC2H2.23%2C probable monooxygenase%2C len: 373 aa%3B similar to SW:TETX_BACFR (EMBL:M37699) Bacteroides fragilis tetracycline resistance protein TetX%2C 388 aa%3B fasta scores: opt: 598 z-score: 663.7 E(): 2e-29%3B 31.3%25 identity in 367 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase gene gene7688 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7625 SCO7626 SCO7626 SC2H2.24c SC2H2.24c 8452226 8453704 - monooxygenase SC2H2.24c%2C probable monooxygenase%2C len: 492 aa%3B similar to SW:MHPA_ECOLI (EMBL:D86239) Escherichia coli 3-(3-hydroxy-phenyl)propionate hydroxylase (EC 1.14.13.-) MhpA%2C 554 aa%3B fasta scores: opt: 521 z-score: 602.2 E(): 5.2e-26%3B 32.6%25 identity in 356 aa overlap. Contains Pfam matches to entries PF01494 FAD_binding_3%2C FAD binding domain and PF01360 Monooxygenase%2C Monooxygenase gene gene7689 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7626 SCO7627 SCO7627 SC2H2.25 SC2H2.25 8453968 8454549 + hypothetical protein SC2H2.25%2C conserved hypothetical protein%2C len: 193 aa%3B similar to TR:Q9XBC6 (EMBL:AL078635) Amycolatopsis orientalis hypothetical 22.9 kDa protein CZA382.25%2C 205 aa%3B fasta scores: opt: 202 z-score: 256.0 E(): 1e-06%3B 31.7%25 identity in 189 aa overlap gene gene7690 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7627 SCO7628 SCO7628 SC10F4.01 SC10F4.01 8454701 8455840 + hypothetical protein SC10F4.01%2C conserved hypothetical protein (fragment)%2C len: >90 aa%3B similar to TR:O52799 (EMBL:AJ223998) Amycolatopsis orientalis hypothetical protein PCZA361.11%2C 495 aa%3B fasta scores: opt: 151 z-score: 192.7 E(): 0.0034%3B 35.4%25 identity in 79 aa overlap~SC2H2.26%2C conserved hypothetical protein (fragment)%2C len: >322 aa%3B similar to TR:O52799 (EMBL:AJ223998) Amycolatopsis orientalis hypothetical protein PCZA361.11%2C 495 aa%3B fasta scores: opt: 757 z-score: 813.7 E(): 0%3B 45.0%25 identity in 333 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7691 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7628 SCO7629 SCO7629 SC10F4.02 SC10F4.02 8455893 8457134 + starvation sensing protein SC10F4.02%2C spaA%2C probable starvation sensing protein%2C len: 413 aa%3B identical to previously sequenced TR:P95726 (EMBL:X94190) Streptomyces coelicolor spaA gene%2C 413 aa. Contains Pfam match to entry PF01188 MR_MLE%2C Mandelate racemase / muconate lactonizing enzyme family and match to Prosite entry PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1 gene gene7692 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7629 SCO7630 SCO7630 SC10F4.03 SC10F4.03 8457210 8457884 + isomerase SC10F4.03%2C probable isomerase%2C len: 224 aa%3B similar to SW:PMG2_ECOLI (EMBL:M97495) Escherichia coli probable phosphoglycerate mutase 2 (EC 5.4.2.1) GpmB%2C 215 aa%3B fasta scores: opt: 190 z-score: 225.8 E(): 4.8e-05%3B 28.5%25 identity in 214 aa overlap and to TR:Q9ZAX0 (EMBL:U73808) Amycolatopsis methanolica 2%2C3-PDG dependent phosphoglycerate mutase PGM%2C 205 aa%3B fasta scores: opt: 518 z-score: 596.0 E(): 1.2e-25%3B 45.5%25 identity in 202 aa overlap. Contains Pfam match to entry PF00300 PGAM%2C Phosphoglycerate mutase family and match to Prosite entry PS00175 Phosphoglycerate mutase family phosphohistidine signature gene gene7693 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7630 SCO7631 SCO7631 SC10F4.04c SC10F4.04c 8457868 8459757 - hypothetical protein SC10F4.04c%2C possible hypothetical protein%2C len: 629 aa. Contains possible N-terminal region signal peptide sequence gene gene7694 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7631 SCO7632 SCO7632 SC10F4.05 SC10F4.05 8460001 8460834 + hypothetical protein SC10F4.05%2C conserved hypothetical protein%2C len: 277 aa%3B similar to TR:O52555 (EMBL:AF040570) Amycolatopsis mediterranei negative regulatory protein RifO%2C 255 aa%3B fasta scores: opt: 503 z-score: 563.6 E(): 7.4e-24%3B 36.4%25 identity in 272 aa overlap gene gene7695 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7632 SCO7633 SCO7633 endoH endoH 8460911 8461840 - endo-beta-N-acetylglucosaminidase SC10F4.06c%2C endo-beta-N-acetylglucosaminidase%2C len: 309 aa%3B highly similar to SW:EBAG_STRPL (EMBL:K02182) Streptomyces plicatus endo-beta-n-acetylglucosaminidase H precursor (EC 3.2.1.96)%2C 313 aa%3B fasta scores: opt: 1769 z-score: 1916.4 E(): 0%3B 86.9%25 identity in 312 aa overlap. Contains match to Prosite entry PS01095 Chitinases family 18 active site and possible N-terminal region signal peptide sequence gene gene7696 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7633 SCO7634 SCO7634 SC10F4.07 SC10F4.07 8461956 8463857 + hypothetical protein SC10F4.07%2C unknown%2C len: 633 aa. High content in alanine%2C arginine%2C glycine and leucine amino acid residues gene gene7697 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7634 SCO7635 SCO7635 SC10F4.08c SC10F4.08c 8463880 8464428 - extracellular small neutral protease SC10F4.08c%2C snp3%2C extracellular small neutral protease%2C len: 182 aa%3B similar to SW:SNPA_STRLI (EMBL:M81703) Streptomyces lividans extracellular small neutral protease precursor (EC 3.4.24.-) SnpA%2C 227 aa%3B fasta scores: opt: 347 z-score: 398.6 E(): 1.1e-14%3B 40.7%25 identity in 140 aa overlap. Contains Pfam match to entry PF02031 Peptidase_M7%2C Streptomyces extracellular neutral proteinase (M7) family and match to Prosite entry PS00142 Neutral zinc metallopeptidases%2C zinc-binding region signature. Also contains possible N-terminal region signal peptide sequence gene gene7698 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7635 SCO7636 SCO7636 SC10F4.09 SC10F4.09 8464588 8464878 + hypothetical protein SC10F4.09%2C possible membrane protein%2C len: 96 aa. Contains possible hydrophobic membrane spanning region gene gene7699 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7636 SCO7637 SCO7637 SC10F4.10c SC10F4.10c 8464939 8466399 - endoglucanase SC10F4.10c%2C endoglucanase%2C len: 486 aa%3B highly similar to SW:GUNA_STRLI (EMBL:M82807) Streptomyces lividans endoglucanase CelA precursor (EC 3.2.1.4) CelA%2C 459 aa%3B fasta scores: opt: 2977 z-score: 3136.1 E(): 0%3B 97.4%25 identity in 461 aa overlap. Contains Pfam matches to entries PF00553 CBD_2%2C Cellulose binding domain and PF00150 cellulase%2C Cellulase (glycosyl hydrolase family 5) and matches to Prosite entries PS00561 Cellulose-binding domain%2C bacterial type and PS00659 Glycosyl hydrolases family 5 signature. Also contains possible N-terminal region signal peptide sequence gene gene7700 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7637 SCO7638 SCO7638 eno eno 8466854 8468158 - phosphopyruvate hydratase enolase%3B catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis gene gene7701 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7638 SCO7639 SCO7639 SC10F4.12 SC10F4.12 8468385 8468807 + MarR family regulatory protein SC10F4.12%2C probable marR-family regulatory protein%2C len: 140 aa%3B similar to TR:AAG06455 (EMBL:AE004731) Pseudomonas aeruginosa probable transcriptional regulator PA3067%2C 147 aa%3B fasta scores: opt: 336 z-score: 402.2 E(): 7.3e-15%3B 43.0%25 identity in 142 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene7702 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7639 SCO7640 SCO7640 SC10F4.13c SC10F4.13c 8468827 8469810 - LysR family transcriptional regulator SC10F4.13c%2C possible lysR-family transcriptional regulator%2C len: 327 aa%3B similar to many other Streptomyces coelicolor lysR-family transcriptional regulators%2C e.g. TR:Q9K3X6 (EMBL:AL359949) lysR-family transcriptional regulator 2SCG61.40c%2C 303 aa%3B fasta scores: opt: 376 z-score: 418.1 E(): 9.5e-16%3B 34.0%25 identity in 318 aa overlap. Contains Pfam match to entry PF00126 HTH_1%2C Bacterial regulatory helix-turn-helix protein%2C lysR family and possible helix-turn-helix motif at residues 16..37 (+5.92 SD) gene gene7703 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7640 SCO7641 SCO7641 SC10F4.14 SC10F4.14 8469909 8471105 + dehydrogenase SC10F4.14%2C possible dehydrogenase%2C len: 398 aa%3B similar to many other Streptomyces coelicolor dehydrogenases%2C e.g. TR:Q9RD04 (EMBL:AL133422) dehydrogenase SCM1.40c%2C 296 aa%3B fasta scores: opt: 352 z-score: 383.2 E(): 8.2e-14%3B 33.5%25 identity in 260 aa overlap gene gene7704 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7641 SCO7642 SCO7642 SC10F4.15 SC10F4.15 8471165 8471530 + hypothetical protein SC10F4.15%2C conserved hypothetical protein%2C len: 121 aa%3B similar to TR:O31535 (EMBL:Z99107) Bacillus subtilis hypothetical protein YetH%2C 120 aa%3B fasta scores: opt: 176 z-score: 223.7 E(): 6.3e-05%3B 29.8%25 identity in 121 aa overlap gene gene7705 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7642 SCO7643 SCO7643 SC10F4.16 SC10F4.16 8471548 8471823 + hypothetical protein SC10F4.16%2C unknown%2C len: 91 aa gene gene7706 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7643 SCO7644 SCO7644 SC10F4.17c SC10F4.17c 8471876 8473099 - ATP binding protein SC10F4.17c%2C possible ATP binding protein%2C len: 407 aa%3B similar to TR:Q9KRL3 (EMBL:AE004240) Vibrio cholerae hypothetical protein VC1624%2C 414 aa%3B fasta scores: opt: 582 z-score: 689.7 E(): 7e-31%3B 29.8%25 identity in 413 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) gene gene7707 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7644 SCO7645 SCO7645 SC10F4.18 SC10F4.18 8473207 8473920 + TetR family transcriptional regulator SC10F4.18%2C possible tetR-family transcriptional regulator%2C len: 237 aa%3B similar to TR:Q53901 (EMBL:M64683) Streptomyces coelicolor ORF1-4 (actII) ActII%2C 259 aa%3B fasta scores: opt: 213 z-score: 261.0 E(): 5.3e-07%3B 25.3%25 identity in 233 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 44..65 (+4.27 SD) gene gene7708 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7645 SCO7646 SCO7646 SC10F4.19 SC10F4.19 8474054 8474326 + hypothetical protein SC10F4.19%2C possible membrane protein%2C len: 90 aa%3B similar to TR:O86580 (EMBL:AL031184) Streptomyces coelicolor small hydrophobic protein SC2A11.19%2C 97 aa%3B fasta scores: opt: 181 z-score: 235.5 E(): 1.4e-05%3B 44.0%25 identity in 91 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7709 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7646 SCO7647 SCO7647 SC10F4.20 SC10F4.20 8474635 8475174 + calcium binding protein SC10F4.20%2C probable calcium binding protein%2C len: 179 aa%3B similar to SW:CBP_SACER (EMBL:M29700) Saccharopolyspora erythraea calerythrin (calcium-binding protein)%2C 177 aa%3B fasta scores: opt: 216 z-score: 256.4 E(): 9.6e-07%3B 25.5%25 identity in 165 aa overlap. Contains 3x Pfam matches to entry PF00036 efhand%2C EF hand and 2x matches to Prosite entry PS00018 EF-hand calcium-binding domain gene gene7710 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7647 SCO7648 SCO7648 SC10F4.21c SC10F4.21c 8475216 8475881 - two-component system response regulator SC10F4.21c%2C probable two-component system response regulator%2C len: 221 aa%3B similar to many other Streptomyces coelicolor response regulators%2C e.g. TR:Q9RKT8 (EMBL:AL132824) response regulator SCAH10.19%2C 229 aa%3B fasta scores: opt: 713 z-score: 802.2 E(): 0%3B 57.2%25 identity in 208 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains possible helix-turn-helix motif at residues 163..184 (+3.19 SD) gene gene7711 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7648 SCO7649 SCO7649 SC10F4.22c SC10F4.22c 8476050 8477246 - two-component system sensor kinase SC10F4.22c%2C probable two-component system sensor kinase%2C len: 398 aa%3B similar to many other Streptomyces coelicolor sensor kinases%2C e.g. TR:Q9RKT9 (EMBL:AL132824) two-component sensor kinase SCAH10.18%2C 417 aa%3B fasta scores: opt: 780 z-score: 815.5 E(): 0%3B 44.0%25 identity in 348 aa overlap. Contains possible hydrophobic membrane spanning regions in the N-terminal domain gene gene7712 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7649 SCO7650 SCO7650 SC10F4.23 SC10F4.23 8477428 8478900 + hydrolase SC10F4.23%2C possible hydrolase%2C len: 490 aa%3B similar to TR:Q9ZBJ5 (EMBL:AL035161) Streptomyces coelicolor peptidase SC9C7.15c%2C 529 aa%3B fasta scores: opt: 678 z-score: 721.7 E(): 1.2e-32%3B 36.6%25 identity in 514 aa overlap. Contains Pfam match to entry PF00561 abhydrolase%2C alpha/beta hydrolase fold and possible N-terminal region signal peptide sequence gene gene7713 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7650 SCO7651 SCO7651 SC10F4.24c SC10F4.24c 8478902 8479516 - TetR family transcriptional regulator SC10F4.24c%2C probable tetR-family transcriptional regulator%2C len: 204 aa%3B similar to TR:O34381 (EMBL:Z99112) Bacillus subtilis transcriptional regulator PksA%2C 205 aa%3B fasta scores: opt: 246 z-score: 297.6 E(): 4.9e-09%3B 27.5%25 identity in 182 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 38..59 (+2.87 SD) gene gene7714 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7651 SCO7652 SCO7652 SC10F4.25 SC10F4.25 8479547 8480098 + acetyltransferase SC10F4.25%2C possible acetyltransferase%2C len: 183 aa%3B similar to TR:Q9Z576 (EMBL:AL035569) Streptomyces coelicolor acetyltransferase SC8D9.15%2C 194 aa%3B fasta scores: opt: 640 z-score: 820.9 E(): 0%3B 51.4%25 identity in 181 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene7715 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7652 SCO7653 SCO7653 SC10F4.26c SC10F4.26c 8480189 8480911 - hypothetical protein SC10F4.26c%2C hypothetical fusion protein%2C len: 240 aa%3B N-terminal and C-terminal domains both similar to the same proteins%2C e.g. TR:Q9KZ80 (EMBL:AL354048) Streptomyces coelicolor hypothetical 15.9 kDa protein SCE25.06%2C 145 aa%3B blastp scores for N-terminal domain: Score %3D 130 (45.8 bits)%2C Expect %3D 3.2e-11%2C Sum P(2) %3D 3.2e-11%3B Identities %3D 39/92 (42%25)%2C Positives %3D 50/92 (54%25) and for C-terminal domain: Score %3D 72 (25.3 bits)%2C Expect %3D 0.22%2C Sum P(2) %3D 0.20%3B Identities %3D 29/90 (32%25)%2C Positives %3D 44/90 (48%25) gene gene7716 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7653 SCO7654 SCO7654 SC10F4.27 SC10F4.27 8481163 8482020 + oxidoreductase SC10F4.27%2C possible oxidoreductase%2C len: 285 aa%3B similar to many other dehydrogenases/oxidoreductases%2C e.g. TR:Q9PCP9 (EMBL:AE003996) Xylella fastidiosa phenylacetaldehyde dehydrogenase XF1729%2C 291 aa%3B fasta scores: opt: 626 z-score: 722.9 E(): 9.9e-33%3B 39.7%25 identity in 292 aa overlap gene gene7717 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7654 SCO7655 SCO7655 SC10F4.28 SC10F4.28 8482077 8483009 + oxidoreductase SC10F4.28%2C possible oxidoreductase%2C len: 310 aa%3B similar to many other oxidoreductases%2C e.g. SW:GS69_BACSU (EMBL:Y14082) Bacillus subtilis general stress protein 69%2C YhdN%2C 331 aa%3B fasta scores: opt: 299 z-score: 349.7 E(): 6.1e-12%3B 29.9%25 identity in 261 aa overlap. Contains 2x Pfam matches to entry PF00248 aldo_ket_red%2C Aldo/keto reductase family gene gene7718 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7655 SCO7656 SCO7656 SC10F4.29 SC10F4.29 8483077 8483598 + hypothetical protein SC10F4.29%2C unknown%2C len: 173 aa gene gene7719 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7656 SCO7657 SCO7657 SC10F4.30 SC10F4.30 8483781 8485538 + hypothetical protein SC10F4.30%2C possible hypothetical protein%2C len: 585 aa. Contains possible N-terminal region signal peptide sequence gene gene7720 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7657 SCO7658 SCO7658 SC10F4.31 SC10F4.31 8485558 8485710 + hypothetical protein SC10F4.31%2C unknown%2C len: 50 aa. TBparse predicted doubtful CDS gene gene7721 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7658 SCO7659 SCO7659 SC10F4.32c SC10F4.32c 8485671 8486792 - oxidoreductase SC10F4.32c%2C probable oxidoreductase%2C len: 373 aa%3B similar to SW:TETX_BACFR (EMBL:M37699) Bacteroides fragilis tetracycline resistance protein TetX%2C 388 aa%3B fasta scores: opt: 524 z-score: 576.3 E(): 1.4e-24%3B 30.2%25 identity in 374 aa overlap and to TR:CAB94636 (EMBL:AL359215) Streptomyces coelicolor hypothetical protein SC2H12.22%2C 373 aa%3B fasta scores: opt: 1709 z-score: 1482.3 E(): 0%3B 71.2%25 identity in 375 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase gene gene7722 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7659 SCO7660 SCO7660 kcsA kcsA 8487119 8487601 + voltage-gated potassium channel SC10F4.33%2C kcsA%2C voltage-gated potassium channel%2C len: 160 aa%3B identical to SW:KCSA_STRLI (EMBL:Z37969) Streptomyces lividans voltage-gated potassium channel KcsA%2C 160 aa. Contains possible hydrophobic membrane spanning regions gene gene7723 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7660 SCO7661 SCO7661 SC10F4.34 SC10F4.34 8487642 8488280 + hypothetical protein SC10F4.34%2C possible hypothetical protein%2C len: 212 aa%3B similar to TR:Q9XBC6 (EMBL:AL078635) Amycolatopsis orientalis hypothetical 22.9 kDa protein CZA382.25%2C 205 aa%3B fasta scores: opt: 324 z-score: 399.0 E(): 1.1e-14%3B 35.8%25 identity in 201 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7724 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7661 SCO7662 SCO7662 cmlR2 cmlR2 8488518 8489696 + chloramphenicol resistance protein SC10F4.35%2C cmlR2%2C chloramphenicol resistance protein%2C len: 392 aa%3B identical to SW:CMLR_STRLI (EMBL:X59968) Streptomyces lividans chloramphenicol resistance protein CmlR%2C 392 aa and similar to TR:Q9KZ03 (EMBL:AL355753) Streptomyces coelicolor chloramphenicol resistance protein cmlR or SC8G12.02%2C 403 aa%3B fasta scores: opt: 942 z-score: 738.7 E(): 0%3B 40.6%25 identity in 397 aa overlap. Contains Pfam match to entry PF00083 sugar_tr%2C Sugar (and other) transporter and possible hydrophobic membrane spanning regions gene gene7725 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7662 SCO7663 SCO7663 SC10F4.36c SC10F4.36c 8489928 8490212 - hypothetical protein SC10F4.36c%2C conserved hypothetical protein%2C len: 94 aa%3B similar to TR:O05862 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 11.0 kDa protein MTCY07D11.22c%2C 101 aa%3B fasta scores: opt: 180 z-score: 238.5 E(): 9.5e-06%3B 34.8%25 identity in 92 aa overlap gene gene7726 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7663 SCO7664 SCO7664 SC10F4.37c SC10F4.37c 8490209 8490745 - hypothetical protein SC10F4.37c%2C conserved hypothetical protein%2C len: 178 aa%3B similar to TR:Q9Y9P2 (EMBL:AP000064) Aeropyrum pernix hypothetical 20.8 kDa protein APE2246%2C 188 aa%3B fasta scores: opt: 318 z-score: 401.6 E(): 7.8e-15%3B 35.7%25 identity in 157 aa overlap gene gene7727 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7664 SCO7665 SCO7665 SC10F4.38c SC10F4.38c 8490754 8490963 - hypothetical protein SC10F4.38c%2C hypothetical protein%2C len: 69 aa%3B similar to TR:Q9XA80 (EMBL:AL096837) Streptomyces coelicolor hypothetical 9.9 kDa protein SCF43A.35c%2C 88 aa%3B fasta scores: opt: 205 z-score: 310.7 E(): 9.1e-10%3B 52.5%25 identity in 61 aa overlap gene gene7728 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7665 SCO7666 SCO7666 SC10F4.39 SC10F4.39 8491153 8492100 + zinc-binding oxidoreductase (fragment) SC4C2.01%2C possible zinc-binding oxidoreductase (fragment)%2C len: >133 aa%3B similar to TR:CAC14345 (EMBL:AL445945) Streptomyces coelicolor zinc-binding oxidoreductase 3SCF60.12%2C 313 aa%3B fasta scores: opt: 218 z-score: 267.4 E(): 2.3e-07%3B 37.8%25 identity in 127 aa overlap~SC10F4.39%2C possible zinc-binding oxidoreductase (fragment)%2C len: >218 aa%3B similar to TR:Q9L2A5 (EMBL:AL137242) Streptomyces coelicolor zinc-binding oxidoreductase SC8F4.21%2C 339 aa%3B fasta scores: opt: 465 z-score: 527.6 E(): 7.5e-22%3B 41.7%25 identity in 211 aa overlap. Contains Pfam match to entry PF00107 adh_zinc%2C Zinc-binding dehydrogenase gene gene7729 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7666 SCO7667 SCO7667 SC4C2.02 SC4C2.02 8492106 8492702 + hypothetical protein SC4C2.02%2C hypothetical protein%2C len: 198 aa%3B similar to TR:Q9RJG7 (EMBL:AL121600) Streptomyces coelicolor hypothetical 26.8 kDa protein SCF76.07%2C 247 aa%3B fasta scores: opt: 283 z-score: 348.2 E(): 7.3e-12%3B 29.1%25 identity in 179 aa overlap. Contains Pfam match to entry PF01966 HD%2C HD domain gene gene7730 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7667 SCO7668 SCO7668 SC4C2.03 SC4C2.03 8492781 8493260 + hypothetical protein SC4C2.03%2C conserved hypothetical protein%2C len: 159 aa%3B similar to TR:O06195 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 24.2 kDa protein MTCYA10.15c%2C 225 aa%3B fasta scores: opt: 235 z-score: 263.9 E(): 3.6e-07%3B 43.7%25 identity in 103 aa overlap gene gene7731 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7668 SCO7669 SCO7669 SC4C2.04c SC4C2.04c 8493549 8494580 - oxidoreductase SC4C2.04c%2C possible oxidoreductase%2C len: 343 aa%3B similar to TR:O06538 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 36.3 kDa protein MTCI65.05c%2C 338 aa%3B fasta scores: opt: 1020 z-score: 1087.7 E(): 0%3B 50.7%25 identity in 339 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase gene gene7732 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7669 SCO7670 SCO7670 SC4C2.05c SC4C2.05c 8494577 8495092 - hypothetical protein SC4C2.05c%2C conserved hypothetical protein%2C len: 171 aa%3B similar to TR:O06539 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 19.0 kDa protein MTCI65.06c%2C 166 aa%3B fasta scores: opt: 697 z-score: 858.3 E(): 0%3B 62.4%25 identity in 165 aa overlap gene gene7733 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7670 SCO7671 SCO7671 SC4C2.06c SC4C2.06c 8495102 8496340 - transferase SC4C2.06c%2C possible transferase%2C len: 412 aa%3B similar to SW:BCSA_BACSU (EMBL:L77246) Bacillus subtilis chalcone synthase (EC 2.3.1.74) BcsA%2C 365 aa%3B fasta scores: opt: 353 z-score: 334.4 E(): 4.3e-11%3B 31.0%25 identity in 339 aa overlap. Contains 2x Pfam matches to entry PF00195 Chal_stil_synt%2C Chalcone and stilbene synthases and match to Prosite entry PS00196 Type-1 copper (blue) proteins signature. Also contains 9x degenerate repeat: GS gene gene7734 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7671 SCO7672 SCO7672 SC4C2.07 SC4C2.07 8496377 8497237 + hypothetical protein SC4C2.07%2C possible integral membrane protein%2C len: 286 aa. Contains possible hydrophobic membrane spanning regions gene gene7735 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7672 SCO7673 SCO7673 SC4C2.08 SC4C2.08 8497424 8497978 + lipoprotein SC4C2.08%2C possible lipoprotein%2C len: 184 aa%3B similar to TR:Q9RCY0 (EMBL:AL133469) Streptomyces coelicolor lipoprotein SCM10.18c%2C 317 aa%3B fasta scores: opt: 343 z-score: 375.0 E(): 2.4e-13%3B 36.2%25 identity in 174 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence gene gene7736 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7673 SCO7674 SCO7674 SC4C2.09 SC4C2.09 8498017 8498415 + metal-binding protein SC4C2.09%2C possible metal-binding protein%2C len: 132 aa%3B similar to SW:AMCY_METEX (EMBL:M57963) Methylobacterium extorquens amicyanin-alpha precursor MauC%2C 119 aa%3B fasta scores: opt: 165 z-score: 185.2 E(): 0.0088%3B 29.8%25 identity in 121 aa overlap. Contains Pfam match to entry PF00127 copper-bind%2C Copper binding proteins%2C plastocyanin/azurin family and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and match to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible N-terminal region signal peptide sequence gene gene7737 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7674 SCO7675 SCO7675 SC4C2.10 SC4C2.10 8498412 8498906 + hypothetical protein SC4C2.10%2C possible integral membrane protein%2C len: 164 aa. Contains possible hydrophobic membrane spanning regions gene gene7738 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7675 SCO7676 SCO7676 SC4C2.11 SC4C2.11 8499061 8499282 + ferredoxin SC4C2.11%2C probable ferredoxin%2C len: 73 aa%3B similar to SW:FER2_STRGO (EMBL:M32239) Streptomyces griseolus ferredoxin 2 SubB%2C 64 aa%3B fasta scores: opt: 236 z-score: 326.6 E(): 1.2e-10%3B 55.7%25 identity in 61 aa overlap gene gene7739 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7676 SCO7677 SCO7677 SC4C2.12 SC4C2.12 8499392 8500978 + solute-binding protein SC4C2.12%2C possible solute-binding protein%2C len: 528 aa%3B similar to TR:P96429 (EMBL:Z79692) Sinorhizobium meliloti periplasmic binding protein ORF23%2C 537 aa%3B fasta scores: opt: 644 z-score: 679.5 E(): 2.6e-30%3B 28.8%25 identity in 525 aa overlap. Contains Pfam match to entry PF00496 SBP_bac_5%2C Bacterial extracellular solute-binding proteins%2C family 5 and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence gene gene7740 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7677 SCO7678 SCO7678 SC4C2.13 SC4C2.13 8500975 8501925 + metal transport integral membrane protein SC4C2.13%2C possible metal transport integral membrane protein%2C len: 316 aa%3B similar to SW:NIKB_ECOLI (EMBL:X73143) Escherichia coli nickel transport system permease NikB%2C 314 aa%3B fasta scores: opt: 490 z-score: 547.6 E(): 5.8e-23%3B 30.4%25 identity in 313 aa overlap. Contains Pfam match to entry PF00528 BPD_transp%2C Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions and possible N-terminal signal peptide sequence gene gene7741 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7678 SCO7679 SCO7679 SC4C2.14 SC4C2.14 8501922 8502776 + transport system integral membrane protein SC4C2.14%2C possible transport system integral membrane protein%2C len: 284 aa%3B similar to SW:Y4TQ_RHISN (EMBL:Z68203) Rhizobium sp. probable peptide ABC transporter permease Y4tQ%2C 291 aa%3B fasta scores: opt: 433 z-score: 466.4 E(): 1.9e-18%3B 33.2%25 identity in 277 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7742 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7679 SCO7680 SCO7680 SC4C2.15 SC4C2.15 8502773 8504398 + ABC transporter ATP-binding protein SC4C2.15%2C possible ABC transporter ATP-binding protein%2C len: 541 aa%3B similar to TR:AAG05449 (EMBL:AE004632) Pseudomonas aeruginosa probable ATP-binding component of ABC transporter PA2061%2C 536 aa%3B fasta scores: opt: 861 z-score: 716.8 E(): 2.2e-32%3B 37.4%25 identity in 522 aa overlap. Contains 2x Pfam matches to entry PF00005 ABC_tran%2C ABC transporter and 2x matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and 2x to PS00211 ABC transporters family signature gene gene7743 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7680 SCO7681 SCO7681 SC4C2.16c SC4C2.16c 8504461 8506122 - 2%2C3-dihydroxybenzoate-AMP ligase SC4C2.16c%2C probable AMP-binding ligase%2C len: 553 aa%3B similar to SW:DHBE_BACSU (EMBL:U26444) Bacillus subtilis 2%2C3-dihydroxybenzoate-AMP ligase (EC 6.3.2.-) DhbE%2C 539 aa%3B fasta scores: opt: 1324 z-score: 1411.8 E(): 0%3B 51.6%25 identity in 539 aa overlap. Contains Pfam match to entry PF00501 AMP-binding%2C AMP-binding enzyme and match to Prosite entry PS00455 AMP-binding domain signature gene gene7744 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7681 SCO7682 SCO7682 SC4C2.17 SC4C2.17 8506283 8512972 + non-ribosomal peptide synthase SC4C2.17%2C probable non-ribosomal peptide synthase%2C len: 2229 aa%3B similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV%2C 2626 aa%3B fasta scores: opt: 2485 z-score: 2429.3 E(): 0%3B 37.9%25 identity in 2203 aa overlap%2C to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2%2C 2035 aa%3B fasta scores: opt: 2251 z-score: 2201.3 E(): 0%3B 33.3%25 identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21%2C 1407 aa%3B fasta scores: opt: 1764 z-score: 1430.4 E(): 0%3B 40.0%25 identity in 1171 aa overlap and to Streptomyces coelicolor SC4C2.18%2C 1842 aa%3B fasta scores: opt: 1742 z-score: 1410.7 E(): 0%3B 43.0%25 identity in 997 aa overlap. Contains Pfam matches to entries 3x PF00550 pp-binding%2C Phosphopantetheine attachment site%2C 3x PF00668 DUF4%2C Domain of unknown function DUF4%2C 2x PF00501 AMP-binding%2C AMP-binding enzyme and matches to Prosite entries 2x PS00455 AMP-binding domain signature%2C PS00678 Trp-Asp (WD) repeats signature%2C 2x PS00012 Phosphopantetheine attachment site and PS00402 Binding-protein-dependent transport systems inner membrane comp sign. gene gene7745 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7682 SCO7683 SCO7683 SC4C2.18 SC4C2.18 8512969 8518497 + non-ribosomal peptide synthase SC4C2.18%2C probable non-ribosomal peptide synthase%2C len: 1842 aa%3B similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV%2C 2626 aa%3B fasta scores: opt: 2514 z-score: 2613.8 E(): 0%3B 40.7%25 identity in 1287 aa overlap%2C to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF%2C 1809 aa%3B fasta scores: opt: 2279 z-score: 2370.9 E(): 0%3B 39.7%25 identity in 1887 aa overlap%2C to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21%2C 1407 aa%3B fasta scores: opt: 1826 z-score: 1476.6 E(): 0%3B 36.7%25 identity in 1315 aa overlap and to C-terminal domain of Streptomyces coelicolor SC4C2.17%2C 2229 aa%3B fasta scores: opt: 1742 z-score: 1405.5 E(): 0%3B 43.0%25 identity in 997 aa overlap. Contains Pfam matches to entries PF00668 DUF4%2C Domain of unknown function DUF4%2C PF00501 AMP-binding%2C AMP-binding enzyme%2C PF00550 pp-binding%2C Phosphopantetheine attachment site and PF00975 Thioesterase%2C Thioesterase domain and matches to Prosite entries PS00455 AMP-binding domain signature and PS00012 Phosphopantetheine attachment site gene gene7746 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7683 SCO7684 SCO7684 SC4C2.19 SC4C2.19 8518494 8519645 + hypothetical protein SC4C2.19%2C conserved hypothetical protein%2C len: 383 aa%3B similar to TR:Q46024 (EMBL:U02634) Corynebacterium diphtheriae DtxR/iron regulated protein 2 Irp2%2C 369 aa%3B fasta scores: opt: 241 z-score: 271.1 E(): 1.5e-07%3B 29.6%25 identity in 382 aa overlap gene gene7747 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7684 SCO7685 SCO7685 SC4C2.20 SC4C2.20 8519642 8521675 + hypothetical protein SC4C2.20%2C conserved hypothetical protein%2C len: 677 aa%3B similar to TR:Q9Z602 (EMBL:AF116557) Pseudomonas aeruginosa protein necessary for the formation of the siderophore pyochelin PchG%2C 349 aa%3B fasta scores: opt: 559 z-score: 589.4 E(): 2.7e-25%3B 36.6%25 identity in 350 aa overlap and to Streptomyces coelicolor hypothetical protein SC4C2.23%2C 242 aa%3B fasta scores: opt: 705 z-score: 579.4 E(): 1.3e-26%3B 50.2%25 identity in 243 aa overlap gene gene7748 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7685 SCO7686 SCO7686 SC4C2.21 SC4C2.21 8521684 8522919 + cytochrome P450 SC4C2.21%2C probable cytochrome P450%2C len: 411 aa%3B similar to SW:CPXE_STRGO (EMBL:M32238) Streptomyces griseolus cytochrome P450-SU1 SuaC%2C405 aa%3B fasta scores: opt: 1113 z-score: 1179.8 E(): 0%3B 45.5%25 identity in 407 aa overlap. Contains Pfam match to entry PF00067 p450%2C Cytochrome P450 and match to Prosite entry PS00086 Cytochrome P450 cysteine heme-iron ligand signature gene gene7749 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7686 SCO7687 SCO7687 SC4C2.22 SC4C2.22 8522916 8523749 + thioesterase SC4C2.22%2C probable thioesterase%2C len: 277 aa%3B similar to SW:PABT_STRGR (EMBL:M93058) Streptomyces griseus probable cadicidin biosynthesis thioesterase (EC 3.1.2.-)%2C 361 aa%3B fasta scores: opt: 638 z-score: 760.5 E(): 0%3B 40.4%25 identity in 277 aa overlap. Contains Pfam match to entry PF00975 Thioesterase%2C Thioesterase domain gene gene7750 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7687 SCO7688 SCO7688 SC4C2.23 SC4C2.23 8523760 8524488 + hypothetical protein SC4C2.23%2C hypothetical protein%2C len: 242 aa%3B similar to TR:CAC04224 (EMBL:AL391515) Streptomyces coelicolor hypothetical 27.9 kDa protein SC4B10.19c%2C 254 aa%3B fasta scores: opt: 222 z-score: 264.0 E(): 3.6e-07%3B 31.8%25 identity in 214 aa overlap and to Streptomyces coelicolor hypothetical protein SC4C2.20%2C 677 aa%3B fasta scores: opt: 705 z-score: 683.1 E(): 2.2e-32%3B 49.8%25 identity in 243 aa overlap gene gene7751 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7688 SCO7689 SCO7689 SC4C2.24 SC4C2.24 8524521 8526347 + ABC transporter ATP-binding protein SC4C2.24%2C probable ABC transporter ATP-binding protein%2C len: 551 aa%3B similar to C-terminal region of SW:YD48_MYCTU (EMBL:Z75555) Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein RV1348%2C 859 aa%3B fasta scores: opt: 1313 z-score: 1377.6 E(): 0%3B 43.8%25 identity in 548 aa overlap. Contains Pfam matches to entries PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains possible hydrophobic membrane spanning regions gene gene7752 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7689 SCO7690 SCO7690 SC4C2.25 SC4C2.25 8526344 8528107 + ABC transporter ATP-binding protein SC4C2.25%2C probable ABC transporter ATP-binding protein%2C len: 587 aa%3B similar to SW:YD49_MYCTU (EMBL:Z75555) Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein RV1349%2C 579 aa%3B fasta scores: opt: 1144 z-score: 1191.3 E(): 0%3B 36.8%25 identity in 590 aa overlap. Contains Pfam matches to entries PF00664 ABC_membrane%2C ABC transporter transmembrane region and PF00005 ABC_tran%2C ABC transporter and matches to Prosite entries PS00038 Myc-type%2C 'helix-loop-helix' dimerization domain signature%2C PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also contains possible hydrophobic membrane spanning regions gene gene7753 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7690 SCO7691 SCO7691 SC4C2.26 SC4C2.26 8528166 8529581 + lyase SC4C2.26%2C possible lyase%2C len: 471 aa%3B C-terminal region similar to C-terminal region of SW:TRPE_HALVO (EMBL:M83788) Halobacterium volcanii anthranilate synthase component I(EC 4.1.3.27) TrpE%2C 523 aa%3B fasta scores: opt: 545 z-score: 624.2 E(): 3.1e-27%3B 38.7%25 identity in 300 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind%2C chorismate binding enzyme gene gene7754 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7691 SCO7692 SCO7692 SC4C2.27 SC4C2.27 8529736 8530005 + hypothetical protein SC4C2.27%2C unknown%2C len: 89 aa gene gene7755 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7692 SCO7693 SCO7693 SC1A4.01c SC1A4.01c 8529982 8530953 - oxidoreductase SC1A4.01c%2C probable oxidoreductase%2C len: 323 aa%3B similar to SW:OXIR_STRAT (EMBL:M96551) Streptomyces antibioticus probable oxidoreductase (EC 1.-.-.-)%2C 298 aa%3B fasta scores: opt: 855 z-score: 920.1 E(): 0%3B 49.8%25 identity in 305 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase gene gene7756 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7693 SCO7694 SCO7694 SC1A4.02 SC1A4.02 8531016 8531588 + TetR family transcriptional regulator SC1A4.02%2C probable tetR-family transcriptional regulator%2C len: 190 aa%3B similar to TR:Q9PBQ5 (EMBL:AE004024) Xylella fastidiosa transcriptional regulator (AcrR family) XF2085%2C 205 aa%3B fasta scores: opt: 170 z-score: 215.3 E(): 0.00019%3B 30.8%25 identity in 117 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and possible helix-turn-helix motif at residues 38..59 (+4.46 SD) gene gene7757 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7694 SCO7695 SCO7695 SC1A4.03c SC1A4.03c 8531641 8532009 - hypothetical protein SC1A4.03c%2C hypothetical protein%2C len: 122 aa%3B similar to TR:Q9K3Q6 (EMBL:AL360034) Streptomyces coelicolor conserved hypothetical protein 2SCG4.08%2C 130 aa%3B fasta scores: opt: 140 z-score: 184.4 E(): 0.0098%3B 31.3%25 identity in 112 aa overlap gene gene7758 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7695 SCO7696 SCO7696 SC1A4.04 SC1A4.04 8532086 8532541 + MarR family transcriptional regulator SC1A4.04%2C possible marR-family transcriptional regulator%2C len: 151 aa%3B similar to SW:YS87_MYCTU (EMBL:Z74024) Mycobacterium tuberculosis hypothetical transcriptional regulator RV2887%2C 139 aa%3B fasta scores: opt: 354 z-score: 441.2 E(): 4.8e-17%3B 43.0%25 identity in 135 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and possible helix-turn-helix motif at residues 55..76 (+2.75 SD) gene gene7759 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7696 SCO7697 SCO7697 SC1A4.05 SC1A4.05 8532741 8534048 + hydrolase SC1A4.05%2C probable hydrolase%2C len: 435 aa%3B similar to SW:PHYT_BACSU (EMBL:AF015775) Bacillus subtilis 3-phytase precursor (EC 3.1.3.8) Phy%2C 382 aa%3B fasta scores: opt: 203 z-score: 223.6 E(): 6.5e-05%3B 31.0%25 identity in 387 aa overlap. Contains Pfam match to entry PF02333 Phytase. Also contains possible N-terminal region signal peptide sequence gene gene7760 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7697 SCO7698 SCO7698 SC1A4.06c SC1A4.06c 8534142 8535284 - MerR family transcriptional regulator SC1A4.06c%2C probable merR-family transcriptional regulator%2C len: 380 aa%3B N-terminal region similar to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA%2C 253 aa%3B fasta scores: opt: 404 z-score: 467.3 E(): 1.7e-18%3B 40.0%25 identity in 185 aa overlap and C-terminal region similar to TR:O87011 (EMBL:U93274) Pseudomonas aeruginosa hypothetical protein YafE%2C 187 aa%3B blastp scores: Score%3D 121 (42.6 bits)%2C Expect%3D 1.6e-05%2C P%3D 1.6e-05%3B Identities%3D 51/144 (35%25)%2C Positives%3D 72/144 (50%25). Contains Pfam match to entry PF00376 merR%2C Bacterial regulatory proteins%2C merR family and possible helix-turn-helix motif at residues 14..35 (+3.15 SD) gene gene7761 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7698 SCO7699 SCO7699 SC1A4.07 SC1A4.07 8535532 8536947 + nucleotide-binding protein SC1A4.07%2C possible nucleotide-binding protein%2C len: 471 aa%3B highly similar to TR:Q54255 (EMBL:L76204) Streptomyces griseus sporulation-specific protein p3%2C 470 aa%3B fasta scores: opt: 2382 z-score: 2757.2 E(): 0%3B 75.8%25 identity in 472 aa overlap and to TR:CAC05970 (EMBL:AL391763) Streptomyces coelicolor nucleotide binding protein 2SC7G11.11%2C 468 aa%3B fasta scores: opt: 1972 z-score: 2283.0 E(): 0%3B 63.5%25 identity in 466 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding%2C Cyclic nucleotide-binding domain gene gene7762 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7699 SCO7700 SCO7700 SC1A4.08 SC1A4.08 8537030 8538352 + cyclase SCBAC12C8.01%2C possible cyclase%2C len: >137aa: strongly similar to C-terminus of TR:Q9F1V8 (EMBL:AB040071) cyclase from Streptomyces griseus (437 aa) fasta scores%3B opt: 788%2C Z-score: 962.7%2C 82.482%25 identity (82.482%25 ungapped) in 137 aa overlap. Previously sequenced as TR:Q9F1Y6 (EMBL:AB035202) ORF2.~SC1A4.08%2C unknown (fragment)%2C len: >367 aa. High content in alanine and proline amino acid residues gene gene7763 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7700 SCO7701 SCO7701 SCBAC12C8.02 SCBAC12C8.02 8538368 8539246 + methyltransferase SCBAC12C8.02%2C possible methyltransferase%2C len: 396aa: similar to many eg. TR:Q9F1V7 (EMBL:AB040071) methyltransferase from Streptomyces griseus (316 aa) fasta scores%3B opt: 1550%2C Z-score: 1809.5%2C 82.246%25 identity (82.545%25 ungapped) in 276 aa overlap. Previously sequenced as TR:Q9F1Y5 (EMBL:AB035202) ORF4. gene gene7764 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7701 SCO7702 SCO7702 SCBAC12C8.03 SCBAC12C8.03 8539362 8540072 + GntR family transcriptional regulator SCBAC12C8.03%2C possible GntR-family transcriptional regulator%2C len: 236aa: similar to many eg. TR:Q9S276 (EMBL:AL096844) GntR-family transcriptional regulator SCI28.07 from Streptomyces coelicolor (230 aa) fasta scores%3B opt: 532%2C Z-score: 608.3%2C 46.262%25 identity (46.698%25 ungapped) in 214 aa overlap and SW:P33233 (LLDR_ECOLI) lactate dehydrogenase operon regulator from Escherichia coli (258 aa) fasta scores%3B opt: 263%2C Z-score: 305.7%2C 29.204%25 identity (31.884%25 ungapped) in 226 aa overlap. Partially previously sequenced as TR:Q9F1Y4 (EMBL:AB035202) ORF5 (fragment). Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and Prosite match to PS00043 Bacterial regulatory proteins%2C gntR family signature. gene gene7765 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7702 SCO7703 SCO7703 SCBAC12C8.04 SCBAC12C8.04 8540069 8541319 + integral membrane transport protein SCBAC12C8.04%2C possible integral membrane transport protein%2C len: 416aa: similar to many eg. TR:BAB35923 (EMBL:AP002558) amino acid/amine transport protein from Escherichia coli O157:H7 (393 aa) fasta scores%3B opt: 953%2C Z-score: 1012.0%2C 41.207%25 identity (41.645%25 ungapped) in 381 aa overlap. Contains Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and multiple possible membrane-spanning hydrophobic regions. gene gene7766 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7703 SCO7704 SCO7704 SCBAC12C8.05 SCBAC12C8.05 8541365 8542072 + TetR family transcriptional regulator SCBAC12C8.05%2C possible TetR-family transcriptional regulator%2C len: 235 aa: similar to many from Streptomyces coelicolor e.g. TR:Q53901 (EMBL:M64683) ORF1-4 (ActII) (259 aa) fasta scores%3B opt: 310%2C Z-score: 362.1%2C 32.889%25 identity (35.071%25 ungapped) in 225 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and Pfam match to entry PF02909 tetR_C%2C Tetracyclin repressor%2C C-terminal all-alpha domain. gene gene7767 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7704 SCO7705 SCO7705 SCBAC12C8.06 SCBAC12C8.06 8542150 8543340 + oxidoreductase SCBAC12C8.06%2C possible oxidoreductase%2C len: 396aa: similar to many eg. SW:Q01911 (TETX_BACFR) tetracycline resistance oxidoreductase from Bacteroides fragilis (388 aa) fasta scores%3B opt: 612%2C Z-score: 673.8%2C 31.818%25 identity (33.427%25 ungapped) in 374 aa overlap and TR:Q9F3M8 (EMBL:AL450350) oxidoreductase SC10F4.32c from Streptomyces coelicolor (373 aa) fasta scores%3B opt: 1391%2C Z-score: 1524.2%2C 59.116%25 identity (60.795%25 ungapped) in 362 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. gene gene7768 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7705 SCO7706 SCO7706 SCBAC12C8.07c SCBAC12C8.07c 8543383 8544237 - DNA-binding protein SCBAC12C8.07c%2C DNA-binding protein%2C len: 284aa: similar to many from Streptomyces coelicolor eg. TR:Q9ADL0 (EMBL:AL451182) DNA-binding protein 2SCK31.04c (291 aa) fasta scores%3B opt: 731%2C Z-score: 816.6%2C 47.778%25 identity in 270 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. gene gene7769 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7706 SCO7707 SCO7707 SCBAC12C8.08 SCBAC12C8.08 8544375 8544659 + hypothetical protein SCBAC12C8.08%2C conserved hypothetical protein%2C len: 94aa: similar to TR:AAK64828 (EMBL:AE007210) hypothetical protein from Rhizobium meliloti pSymA Megaplasmid (83 aa) fasta scores%3B opt: 346%2C Z-score: 453.2%2C 65.753%25 identity (65.753%25 ungapped) in 73 aa overlap. gene gene7770 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7707 SCO7708 SCO7708 SCBAC12C8.09c SCBAC12C8.09c 8544693 8545343 - hypothetical protein SCBAC12C8.09c%2C conserved hypothetical protein%2C len: 216aa: similar to many eg. TR:O86609 (EMBL:AL031155) hypothetical protein from Streptomyces coelicolor (211 aa) fasta scores%3B opt: 764%2C Z-score: 865.8%2C 54.673%25 identity (55.981%25 ungapped) in 214 aa overlap. gene gene7771 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7708 SCO7709 SCO7709 SCBAC12C8.10 SCBAC12C8.10 8545444 8545872 + MarR family transcriptional regulator SCBAC12C8.10%2C possible MarR-family transcriptional regulator%2C len: 142 aa: similar to many e.g. TR:Q9F3P8 (EMBL:AL450350) MarR-family regulatory protein SC10F4.12 from Streptomyces coelicolor fasta scores%3B opt: 337%2C Z-score: 398.2%2C 46.923%25 identity in 130 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family. gene gene7772 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7709 SCO7710 SCO7710 SC8D11.01 SC8D11.01 8545981 8546727 + phosphotransferase SC8D11.01%2C unknown (fragment)%2C len: >37 aa~SCBAC12C8.11%2C possible phosphotransferase%2C len: 248 aa: similar to SW:P18623 (VPH_STRVI) viomycin resistance phosphotransferase Vph from Streptomyces vinaceus (287 aa) fasta scores%3B opt: 17%2C3 Z-score: 197.2%2C 31.527%25 identity (37.870%25 ungapped) in 203 aa overlap. gene gene7773 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7710 SCO7711 SCO7711 SC8D11.02 SC8D11.02 8546786 8548315 + two component system sensor kinase SC8D11.02%2C possible two component system sensor kinase%2C len: 509 aa%3B similar to TR:Q53893 (EMBL:U51332) Streptomyces coelicolor AbsA1%2C 571 aa%3B fasta scores: opt: 852 z-score: 873.7 E(): 0%3B 42.1%25 identity in 489 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7774 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7711 SCO7712 SCO7712 SC8D11.03 SC8D11.03 8548323 8549003 + two component system response regulator SC8D11.03%2C possible two component system response regulator%2C len: 226 aa%3B similar to TR:Q53894 (EMBL:U51332) Streptomyces coelicolor AbsA2%2C 222 aa%3B fasta scores: opt: 763 z-score: 842.6 E(): 0%3B 55.3%25 identity in 219 aa overlap. Contains Pfam matches to entries PF00072 response_reg%2C Response regulator receiver domain and PF00196 GerE%2C Bacterial regulatory proteins%2C luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins%2C luxR family signature. Also contains possible helix-turn-helix motif at residues 174..195 (+3.33 SD) gene gene7775 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7712 SCO7713 SCO7713 SC8D11.04 SC8D11.04 8549088 8549492 + hypothetical protein SC8D11.04%2C unknown%2C len: 134 aa. TBparse predicted gene gene7776 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7713 SCO7714 SCO7714 SC8D11.05 SC8D11.05 8549883 8550365 + acetyltransferase SC8D11.05%2C possible acetyltransferase%2C len: 160 aa%3B low similarity to TR:Q9ZF48 (EMBL:AJ000733) Bacillus megaterium hypothetical 18.7 kDa protein%2C 160 aa%3B fasta scores: opt: 159 z-score: 209.7 E(): 0.00038%3B 26.0%25 identity in 154 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene7777 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7714 SCO7715 SCO7715 SC8D11.06 SC8D11.06 8550431 8551234 + hypothetical protein SC8D11.06%2C hypothetical protein%2C len: 267 aa%3B similar to TR:Q9RK84 (EMBL:AL132662) Streptomyces coelicolor hypothetical 29.4 kDa protein SCF11.05%2C 271 aa%3B fasta scores: opt: 918 z-score: 1092.7 E(): 0%3B 55.9%25 identity in 254 aa overlap gene gene7778 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7715 SCO7716 SCO7716 SC8D11.07 SC8D11.07 8551498 8551953 + hypothetical protein SC8D11.07%2C hypothetical protein%2C len: 151 aa%3B similar to TR:Q9L188 (EMBL:AL158057) Streptomyces coelicolor hypothetical 18.3 kDa protein SC10G8.14%2C 168 aa%3B fasta scores: opt: 428 z-score: 542.8 E(): 1.1e-22%3B 46.8%25 identity in 139 aa overlap gene gene7779 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7716 SCO7717 SCO7717 SC8D11.08c SC8D11.08c 8552007 8552420 - hypothetical protein SC8D11.08c%2C possible hypothetical protein%2C len: 137 aa%3B similar to TR:Q9Z4W4 (EMBL:AL035654) Streptomyces coelicolor hypothetical 14.7 kDa protein SCE8.13c%2C 142 aa%3B fasta scores: opt: 173 z-score: 209.1 E(): 0.00041%3B 38.5%25 identity in 143 aa overlap. Contains possible N-terminal region signal peptide sequence gene gene7780 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7717 SCO7718 SCO7718 SC8D11.09c SC8D11.09c 8552524 8553297 - hypothetical protein SC8D11.09c%2C unknown%2C len: 257 aa gene gene7781 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7718 SCO7719 SCO7719 SC8D11.10c SC8D11.10c 8553428 8554087 - TetR family transcriptional regulator SC8D11.10c%2C probable tetR-family transcriptional regulator%2C len: 219 aa%3B similar to SW:TCMR_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR%2C 226 aa%3B fasta scores: opt: 249 z-score: 288.5 E(): 1.6e-08%3B 34.4%25 identity in 195 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and a possible helix-turn-helix motif at residues 37..58 (+5.10 SD) gene gene7782 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7719 SCO7720 SCO7720 SC8D11.11 SC8D11.11 8554142 8555248 + hypothetical protein SC8D11.11%2C unknown%2C len: 368 aa gene gene7783 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7720 SCO7721 SCO7721 SC8D11.12 SC8D11.12 8555357 8556118 + hypothetical protein SC8D11.12%2C conserved hypothetical protein%2C len: 253 aa%3B similar to TR:O86750 (EMBL:AL031035) Streptomyces coelicolor hypothetical 28.3 kDa protein SC6A9.18c%2C 266 aa%3B fasta scores: opt: 418 z-score: 520.0 E(): 2e-21%3B 36.6%25 identity in 246 aa overlap gene gene7784 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7721 SCO7722 SCO7722 SC8D11.13 SC8D11.13 8556355 8556939 + hypothetical protein SC8D11.13%2C hypothetical protein%2C len: 194 aa%3B similar to TR:Q9L045 (EMBL:AL163672) Streptomyces coelicolor hypothetical 22.3 kDa protein SCE50.18c%2C 203 aa%3B fasta scores: opt: 588 z-score: 709.1 E(): 5.8e-32%3B 49.7%25 identity in 189 aa overlap gene gene7785 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7722 SCO7723 SCO7723 SC8D11.14c SC8D11.14c 8557122 8558303 - hypothetical protein SC8D11.14c%2C unknown%2C len: 393 aa gene gene7786 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7723 SCO7724 SCO7724 SC8D11.15c SC8D11.15c 8558433 8559848 - hypothetical protein SC8D11.15c%2C hypothetical protein%2C len: 471 aa%3B similar to TR:Q9WX25 (EMBL:AL079345) Streptomyces coelicolor membrane protein SCE68.06c%2C 464 aa%3B fasta scores: opt: 428 z-score: 361.4 E(): 1.4e-12%3B 40.4%25 identity in 478 aa overlap gene gene7787 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7724 SCO7725 SCO7725 SC8D11.16 SC8D11.16 8559885 8560667 + hypothetical protein SC8D11.16%2C unknown%2C len: 260 aa. High content in alanine amino acid residues gene gene7788 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7725 SCO7726 SCO7726 SC8D11.17 SC8D11.17 8561544 8562200 + hydrolase SC8D11.17%2C possible hydrolase%2C len: 218 aa%3B similar to SW:YCAC_ECOLI (EMBL:J03412) Escherichia coli 23.1 kDa protein in DmsC-PflA intergenic region YcaC%2C 208 aa%3B fasta scores: opt: 631 z-score: 780.3 E(): 0%3B 48.5%25 identity in 200 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family gene gene7789 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7726 SCO7727 SCO7727 SC8D11.18c SC8D11.18c 8562591 8563058 - MarR family regulatory protein SC8D11.18c%2C possible marR-family regulatory protein%2C len: 155 aa%3B similar to TR:Q9X5U1 (EMBL:AF127374) Streptomyces lavendulae repressor MmcW%2C 163 aa%3B fasta scores: opt: 351 z-score: 450.9 E(): 1.4e-17%3B 36.2%25 identity in 152 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene7790 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7727 SCO7728 SCO7728 SC8D11.19 SC8D11.19 8563210 8563518 + hypothetical protein SC8D11.19%2C conserved hypothetical protein%2C len: 102 aa%3B similar to TR:Q9RTC1 (EMBL:AE002024) Deinococcus radiodurans conserved hypothetical protein DR1844%2C 93 aa%3B fasta scores: opt: 232 z-score: 318.9 E(): 3.2e-10%3B 45.8%25 identity in 83 aa overlap gene gene7791 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7728 SCO7729 SCO7729 SC8D11.20 SC8D11.20 8563625 8564623 + hypothetical protein SC8D11.20%2C hypothetical protein%2C len: 332 aa%3B highly similar to TR:Q9RJG6 (EMBL:AL121600) Streptomyces coelicolor hypothetical 34.3 kDa protein SCF76.08c%2C 325 aa%3B fasta scores: opt: 1541 z-score: 1742.5 E(): 0%3B 71.4%25 identity in 311 aa overlap gene gene7792 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7729 SCO7730 SCO7730 SC8D11.21 SC8D11.21 8564658 8564996 + hypothetical protein SC8D11.21%2C conserved hypothetical protein%2C len: 112 aa%3B similar to TR:Q9RTC1 (EMBL:AE002024) Deinococcus radiodurans conserved hypothetical protein DR1844%2C 93 aa%3B fasta scores: opt: 259 z-score: 352.8 E(): 4.1e-12%3B 42.4%25 identity in 85 aa overlap gene gene7793 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7730 SCO7731 SCO7731 SC8D11.22 SC8D11.22 8565486 8566037 + hypothetical protein SC8D11.22%2C unknown%2C len: 183 aa gene gene7794 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7731 SCO7732 SCO7732 SC8D11.23 SC8D11.23 8566732 8567118 + hypothetical protein SC8D11.23%2C unknown%2C len: 128 aa gene gene7795 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7732 SCO7733 SCO7733 SC8D11.24 SC8D11.24 8567132 8569351 + transcriptional regulator SC8D11.24%2C possible transcriptional regulatory protein%2C len: 739 aa. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. Also contains a possible helix-turn-helix motif at residues 40..61 (+4.44 SD) gene gene7796 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7733 SCO7734 SCO7734 SC8D11.25 SC8D11.25 8569361 8569918 + hypothetical protein SC8D11.25%2C unknown%2C len: 185 aa gene gene7797 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7734 SCO7735 SCO7735 SC8D11.26 SC8D11.26 8569962 8570174 + hypothetical protein SC8D11.26%2C unknown%2C len: 70 aa gene gene7798 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7735 SCO7736 SCO7736 SC8D11.27c SC8D11.27c 8570209 8572470 - hypothetical protein SC8D11.27c%2C possible integral membrane protein%2C len: 753 aa%3B similar to TR:Q9K4J6 (EMBL:AL357613) Streptomyces coelicolor hypothetical 79.6 kDa protein SC5F8.28c%2C 752 aa%3B fasta scores: opt: 773 z-score: 865.8 E(): 0%3B 37.3%25 identity in 743 aa overlap. Contains 10 possible hydrophobic membrane spanning regions gene gene7799 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7736 SCO7737 SCO7737 SC8D11.28 SC8D11.28 8573140 8573652 + hypothetical protein SC8D11.28%2C unknown%2C len: 170 aa gene gene7800 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7737 SCO7738 SCO7738 SC8D11.29c SC8D11.29c 8573919 8574302 - hypothetical protein SC8D11.29c%2C conserved hypothetical protein%2C len: 127 aa%3B similar to SW:Y854_PYRHO (EMBL:AP000003) Pyrococcus horikoshii hypothetical protein PH854%2C 137 aa%3B fasta scores: opt: 338 z-score: 424.9 E(): 3.9e-16%3B 45.1%25 identity in 122 aa overlap. Contains Pfam match to entry PF01042 UPF0076%2C Domain of unknown function UPF0076 gene gene7801 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7738 SCO7739 SCO7739 SC8D11.30c SC8D11.30c 8574364 8575071 - hydrolase SC8D11.30c%2C possible hydrolase%2C len: 235 aa%3B similar to C-terminal region of SW:PCD_ARTOX (EMBL:M94965) Arthrobacter oxidans phemedipham hydrolase (EC 3.1.1.-) Pcd%2C 493 aa%3B fasta scores: opt: 219 z-score: 259.2 E(): 6.7e-07%3B 28.1%25 identity in 199 aa overlap. Contains 2x Pfam matches to entry PF00135 COesterase%2C Carboxylesterases gene gene7802 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7739 SCO7740 SCO7740 SC8D11.31c SC8D11.31c 8575438 8575674 - hypothetical protein SC8D11.31c%2C hypothetical protein%2C len: 78 aa%3B similar to N-terminal domain of SW:YIS1_STRCO (EMBL:Y00434) Streptomyces coelicolor insertion element IS110 hypothetical 43.6 kDa protein SC3C8.10%2C 405 aa%3B fasta scores: opt: 292 z-score: 354.8 E(): 4.6e-14%3B 68.8%25 identity in 64 aa overlap gene gene7803 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7740 SCO7741 SCO7741 SC8D11.32c SC8D11.32c 8576308 8577372 - hypothetical protein SC8D11.32c%2C possible bifunctional protein%2C len: 354 aa%3B N-terminal region similar to TR:Q9RKU1 (EMBL:AL132824) Streptomyces coelicolor reductase SCAH10.16%2C 185 aa%3B fasta scores: opt: 387 z-score: 473.3 E(): 8e-19%3B 39.0%25 identity in 187 aa overlap and C-terminal region similar to SW:YIEF_ECOLI (EMBL:L10328) Escherichia coli hypothetical 20.4 kDa protein YieF%2C 188 aa%3B blastp scores: Score%3D 148 (52.1 bits)%2C Expect%3D 7.0e-10%2C P%3D 7.0e-10%3B Identities%3D 49/139 (35%25)%2C Positives%3D 78/139 (56%25). Contains Pfam match in C-terminal region to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family gene gene7804 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7741 SCO7742 SCO7742 SC8D11.33 SC8D11.33 8577403 8577879 + MarR family transcriptional regulator SC8D11.33%2C probable MarR-family transcriptional regulator%2C len: 132 aa%3B similar to TR:Q9X5U1 (EMBL:AF127374) Streptomyces lavendulae repressor MmcW%2C 163 aa%3B fasta scores: opt: 268 z-score: 334.9 E(): 4.1e-11%3B 36.9%25 identity in 141 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family. Also contains possible helix-turn-helix motif at residues 63..84 (+3.77 SD) gene gene7805 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7742 SCO7743 SCO7743 SC8D11.34c SC8D11.34c 8578000 8578485 - hypothetical protein SC8D11.34c%2C unknown%2C len: 161 aa gene gene7806 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7743 SCO7744 SCO7744 SC8D11.35c SC8D11.35c 8578618 8578767 - gene gene7807 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7744 SCO7745 SCO7745 SC8D11.36c SC8D11.36c 8578763 8578870 - gene gene7808 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7745 SCO7746 SCO7746 SC8D11.37c SC8D11.37c 8579043 8579414 - insertion element transposase SC8D11.37c%2C possible insertion element transposase%2C len: 123 aa%3B similar to TR:Q9XBE2 (EMBL:AL078635) Amycolatopsis orientalis transposase CZA382.09%2C 142 aa%3B fasta scores: opt: 369 z-score: 493.0 E(): 6.4e-20%3B 45.4%25 identity in 119 aa overlap and to Streptomyces coelicolor SCP1.214%2C 140 aa%3B fasta scores: opt: 419 z-score: 472.1 E(): 1.3e-20%3B 50.4%25 identity in 115 aa overlap gene gene7809 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7746 SCO7747 SCO7747 SC8D11.38 SC8D11.38 8580056 8581234 + hypothetical protein SC8D11.38%2C hypothetical protein%2C len: 392 aa%3B similar to TR:Q9L195 (EMBL:AL158057) Streptomyces coelicolor hypothetical 47.1 kDa protein SC10G8.07c%2C 437 aa%3B fasta scores: opt: 419 z-score: 494.1 E(): 5.5e-20%3B 28.5%25 identity in 393 aa overlap gene gene7810 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7747 SCO7748 SCO7748 SC8D11.39 SC8D11.39 8581406 8583109 + hypothetical protein SC8D11.39%2C hypothetical protein%2C len: 567 aa%3B similar to TR:CAC14487 (EMBL:AL446003) Streptomyces coelicolor DNA-binding protein SC5E9.07%2C 531 aa%3B fasta scores: opt: 473 z-score: 523.3 E(): 1.3e-21%3B 30.3%25 identity in 433 aa overlap. Contains match to Prosite entry PS00237 G-protein coupled receptors signature and 4x degenerate repeat: HAVVP gene gene7811 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7748 SCO7749 SCO7749 SC8D11.40 SC8D11.40 8583106 8584200 + hypothetical protein SC8D11.40%2C unknown%2C len: 364 aa gene gene7812 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7749 SCO7750 SCO7750 SC8D11.41 SC8D11.41 8584197 8584610 + hypothetical protein SC8D11.41%2C hypothetical protein%2C len: 137 aa%3B low similarity to TR:Q9RIS6 (EMBL:AJ249581) Streptomyces coelicolor anti anti sigma factor SCE25.08c%2C 125 aa%3B fasta scores: opt: 110 z-score: 148.5 E(): 0.98%3B 33.8%25 identity in 77 aa overlap gene gene7813 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7750 SCO7751 SCO7751 SC8D11.42 SC8D11.42 8584661 8585167 + regulatory protein SC8D11.42%2C possible regulatory protein%2C len: 168 aa%3B similar to TR:P71672 (EMBL:Z80108) Mycobacterium tuberculosis hypothetical 17.5 kDa protein CY21B4.21 precursor%2C 160 aa%3B fasta scores: opt: 206 z-score: 269.5 E(): 1.8e-07%3B 27.8%25 identity in 144 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family gene gene7814 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7751 SCO7752 SCO7752 SC8D11.43c SC8D11.43c 8585463 8586017 - hypothetical protein SC8D11.43c%2C possible integral membrane protein%2C len: 184 aa%3B similar to TR:Q9X7R2 (EMBL:AL049863) Streptomyces coelicolor possible membrane protein SC5H1.04c%2C 167 aa%3B fasta scores: opt: 505 z-score: 631.2 E(): 1.3e-27%3B 48.7%25 identity in 150 aa overlap. Contains possible hydrophobic membrane spanning regions gene gene7815 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7752 SCO7753 SCO7753 SC5E9.01c SC5E9.01c 8586108 8586500 - hypothetical protein SC5E9.01c%2C unknown%2C len: 93 aa~SC8D11.44c%2C unknown (fragment)%2C len: >76 aa gene gene7816 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7753 SCO7754 SCO7754 SC5E9.02 SC5E9.02 8586592 8586975 + anti-sigma factor antagonist SC5E9.02%2C possible anti-sigma factor antagonist%2C len: 127aa%3B weakly similar to many eg. SW:Q9WVX8 (RSBV_STRCO) anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa) fasta scores%3B opt: 118%2C z-score: 164.6%2C E(): 0.11%2C 27.7%25 identity in 94 aa overlap. Contains Pfam match to entry PF01740 STAS%2C STAS domain. gene gene7817 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7754 SCO7755 SCO7755 SC5E9.03 SC5E9.03 8587133 8587375 + hypothetical protein SC5E9.03%2C conserved hypothetical protein%2C len: 80aa%3B similar to others from Streptomyces coelicolor eg. TR:O54206 (EMBL:AJ001206) pepA hypothetical protein from the glycogen metabolism cluster (90 aa) fasta scores%3B opt: 116%2C z-score: 182.1%2C E(): 0.011%2C 36.3%25 identity in 80 aa overlap. gene gene7818 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7755 SCO7756 SCO7756 SC5E9.04 SC5E9.04 8587396 8587620 + hypothetical protein SC5E9.04%2C unknown%2C len: 74 aa gene gene7819 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7756 SCO7757 SCO7757 SC5E9.05c SC5E9.05c 8588247 8589100 - gene gene7820 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7757 SCO7759 SCO7759 SC5E9.07 SC5E9.07 8589189 8590784 + DNA-binding protein SC5E9.07%2C possible DNA-binding protein%2C len: 531aa%3B similar to many conserved hypothetical proteins eg. TR:Q9X8W1 (EMBL:AL078610) hypothetical protein from Streptomyces coelicolor (634 aa) fasta scores%3B opt: 1459%2C z-score: 1666.8%2C E(): 0%2C 48.8%25 identity in 531 aa overlap. Contains helix-turn-helix motif (Score 1136 (+3.06 SD)) at residue 18-39. Note possible alternative translational start sites. Also contains Pfam match to entry PF01590 GAF%2C GAF domain. gene gene7821 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7759 SCO7760 SCO7760 SC5E9.08c SC5E9.08c 8590974 8591087 - oxidoreductase fragment SC5E9.08c%2C partial CDS%2C possible oxidoreductase fragment%2C len: 38aa%3B similar to a region from many eg. SW:Q49117 (YMEC_METEX) hypothetical oxidoreductase from Methylobacterium extorquens (153 aa) fasta scores%3B opt: 139%2C z-score: 220.3%2C E(): 8.3e-05%2C 50.0%25 identity in 38 aa overlap. Contains Pfam match to entry PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. gene gene7822 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7760 SCO7761 SCO7761 SC5E9.09 SC5E9.09 8591283 8591942 + hypothetical protein SC5E9.09%2C unknown%2C doubtful CDS%2C len: 219aa%3B appears to lie within a region of degraded DNA. gene gene7823 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7761 SCO7762 SCO7762 SC5E9.10 SC5E9.10 8592094 8593056 + hypothetical protein SC5E9.10%2C unknown%2C doubtful CDS%2C len: 320 aa%3B appears to lie within a region of degraded DNA. gene gene7824 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7762 SCO7763 SCO7763 SC5E9.11 SC5E9.11 8593351 8594052 + hypothetical protein SC5E9.11%2C possible membrane protein%2C len: 233aa%3B contains a possible membrane-spanning hydrophobic region. gene gene7825 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7763 SCO7764 SCO7764 SC5E9.12 SC5E9.12 8594110 8594421 + hypothetical protein SC5E9.12%2C unknown%2C len: 103 aa gene gene7826 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7764 SCO7765 SCO7765 SC5E9.13 SC5E9.13 8595004 8595444 + transcriptional regulator SC5E9.13%2C possible transcriptional regulator%2C len: 146 aa%3B weak similar to many e.g. SW:P27245 (MARR_ECOLI) multiple antibiotic resistance protein MarR from Escherichia coli (125 aa) fasta scores%3B opt: 138%2C z-score: 184.9%2C E(): 0.0079%2C 26.5%25 identity in 117 aa overlap. Contains Pfam match to entry PF01047 MarR%2C MarR family and helix-turn-helix motif (Score 1478 (+4.22 SD)) at residue 43-64. gene gene7827 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7765 SCO7766 SCO7766 SC5E9.14 SC5E9.14 8595528 8596418 + hypothetical protein SC5E9.14%2C conserved hypothetical protein%2C len: 296aa%3B similar to TR:Q53906 (EMBL:X58833) hypothetical protein from the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor (294 aa) fasta scores%3B opt: 546%2C z-score: 609.8%2C E(): 1.7e-26%2C 39.2%25 identity in 288 aa overlap gene gene7828 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7766 SCO7767 SCO7767 SC5E9.15c SC5E9.15c 8596583 8597410 - DNA-binding protein SC5E9.15c%2C possible DNA-binding protein%2C len: 275 aa%3B similar to many e.g. TR:Q9RD19 (EMBL:AL133422) DNA-binding protein from Streptomyces coelicolor (279 aa) fasta scores%3B opt: 510%2C z-score: 601.1%2C E(): 5.1e-26%2C 36.4%25 identity in 275 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix and a possible helix-turn-helix motif at residues 40..61 (+3.20 SD) gene gene7829 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7767 SCO7768 SCO7768 SC5E9.16 SC5E9.16 8597540 8597980 + hypothetical protein SC5E9.16%2C conserved hypothetical protein%2C len: 146aa%3B similar to SW:O31511 (YESE_BACSU) hypothetical protein from Bacillus subtilis (147 aa) fasta scores%3B opt: 317%2C z-score: 427.2%2C E(): 2.5e-16%2C 35.7%25 identity in 126 aa overlap. gene gene7830 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7768 SCO7769 SCO7769 SC5E9.17 SC5E9.17 8597980 8598822 + hypothetical protein SC5E9.17%2C conserved hypothetical protein%2C len: 280 aa%3B similar to many e.g. TR:O31512 (EMBL:Z99107) hypothetical protein from Bacillus subtilis (286 aa) fasta scores%3B opt: 651%2C z-score: 727.7%2C E(): 0%2C 38.1%25 identity in 278 aa overlap gene gene7831 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7769 SCO7770 SCO7770 SC5E9.18 SC5E9.18 8598830 8599405 + hypothetical protein SC5E9.18%2C unknown%2C len: 191 aa%3B similar to a region from several predicted ATP/GTP-binding proteins eg. TR:O86768 (EMBL:AL031035) from Streptomyces coelicolor (886 aa) fasta scores%3B opt: 448%2C z-score: 543.2%2C E(): 8.6e-23%2C 44.2%25 identity in 172 aa overlap gene gene7832 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7770 SCO7771 SCO7771 SC5E9.19c SC5E9.19c 8599443 8599944 - gene gene7833 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7771 SCO7772 SCO7772 SC5E9.20c SC5E9.20c 8600297 8600881 - hypothetical protein SC5E9.20c%2C unknown%2C len: 194 aa gene gene7834 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7772 SCO7773 SCO7773 SC5E9.21c SC5E9.21c 8601284 8601808 - hypothetical protein SC5E9.21c%2C conserved hypothetical protein%2C len: 174aa%3B weakly similar to many eg. TR:Q00818 (EMBL:M95287) hypothetical protein from plasmid IncN R46 of Salmonella typhimurium (162 aa) fasta scores%3B opt: 188%2C z-score: 238.9%2C E(): 7.7e-06%2C 29.3%25 identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene7835 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7773 SCO7774 SCO7774 SC5E9.22 SC5E9.22 8602543 8603184 + hypothetical protein SC5E9.22%2C possible hypothetical protein%2C len: 213aa%3B region similar to many eg. SW:P96463 (ABFB_STRLI) alpha-L-arabinofuranosidase precursor from Streptomyces lividans (475 aa) fasta scores%3B opt: 171%2C z-score: 209.1%2C E(): 0.00036%2C 32.2%25 identity in 177 aa overlap. Contains a possible N-terminal signal sequence. Similar to neighbouring CDS SC5E9.23 fasta scores%3B opt: 371%2C z-score: 401.0%2C E(): 1.1e-16%2C 42.2%25 identity in 173 aa overlap. gene gene7836 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7774 SCO7775 SCO7775 SC5E9.23 SC5E9.23 8603181 8603747 + hypothetical protein SC5E9.23%2C possible hypothetical protein%2C len: 188aa%3B similar to regions from others eg. TR:Q9X583 (EMBL:AF121864) xylanase-arabinofuranosidase bifunctional enzyme from Streptomyces chattanoogensis (819 aa) fasta scores%3B opt: 198%2C z-score: 237.6%2C E(): 9.1e-06%2C 29.4%25 identity in 177 aa overlap. Contains possible N-terminal signal sequence and Pfam match to entry PF00652 Ricin_B_lectin%2C Similarity to lectin domain of ricin beta-chain. Similar to neighbouring CDS SC5E9.22 fasta scores%3B opt: 371%2C z-score: 401.0%2C E(): 1.1e-16%2C 42.2%25 identity in 173 aa overlap. gene gene7837 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7775 SCO7776 SCO7776 SC5E9.24 SC5E9.24 8604333 8604653 + hypothetical protein SC5E9.24%2C unknown%2C len: 106 aa%3B some similarity to TR:Q9Z3X0 (EMBL:AF073359) 4-oxalocrotonate isomerase from Sphingomonas sp. DJ77 (77 aa) fasta scores%3B opt: 91%2C z-score: 135.8%2C E(): 4.3%2C 32.8%25 identity in 61 aa overlap. gene gene7838 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7776 SCO7777 SCO7777 SC5E9.25c SC5E9.25c 8604711 8605640 - hydrolase SC5E9.25c%2C possible hydrolase%2C len: 309aa%3B weakly similar to many eg. TR:O69356 (EMBL:D88016) 2-hydroxy-6-oxo-6-phenylhexa-2%2C4-dienoate hydrolase from Rhodococcus erythropolis (281 aa) fasta scores%3B opt: 206%2C z-score: 247.2%2C E(): 2.7e-06%2C 26.3%25 identity in 281 aa overlap. gene gene7839 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7777 SCO7778 SCO7778 SC5E9.26 SC5E9.26 8605797 8606564 + transcriptional regulator SC5E9.26%2C possible transcriptional regulator%2C len: 255 aa%3B similar to many e.g. SW:P15360 (GYLR_STRCO) glycerol operon regulatory protein from Streptomyces coelicolor (254 aa) fasta scores%3B opt: 217%2C z-score: 260.0%2C E(): 5.1e-07%2C 28.1%25 identity in 249 aa overlap and TR:O88025 (EMBL:AL031107) transcriptional regulator from Streptomyces coelicolor (264 aa) fasta scores%3B opt: 462%2C z-score: 543.0%2C E(): 9e-23%2C 40.5%25 identity in 242 aa overlap. Contains Pfam match to entry PF01614 IclR%2C Bacterial transcriptional regulator. gene gene7840 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7778 SCO7779 SCO7779 SC5E9.27c SC5E9.27c 8606671 8607405 - oxidoreductase SC5E9.27c%2C possible oxidoreductase%2C len: 244aa%3B similar to many eg. SW:P16544 (ACT3_STRCO) ketoacyl reductase from Streptomyces coelicolor (261 aa) fasta scores%3B opt: 236%2C z-score: 270.7%2C E(): 1.3e-07%2C 31.3%25 identity in 233 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene7841 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7779 SCO7780 SCO7780 SC5E9.28 SC5E9.28 8607539 8608480 + transcriptional regulator SC5E9.28%2C possible transcriptional regulator%2C len: 313aa%3B strongly similar to TR:Q54308 (EMBL:X86780) helix-turn-helix DNA binding protein from Streptomyces hygroscopicus (330 aa) fasta scores%3B opt: 921%2C z-score: 1007.9%2C E(): 0%2C 50.5%25 identity in 309 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family and Prosite match to PS00041 Bacterial regulatory proteins%2C araC family signature. gene gene7842 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7780 SCO7781 SCO7781 SC5E9.29 SC5E9.29 8608584 8608864 + gene gene7843 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7781 SCO7782 SCO7782 SC5E9.30 SC5E9.30 8609130 8610347 + IS110 transposase SC5E9.30%2C probable IS110 transposase%2C len: 405aa%3B identical to SW:P19780 (YIS1_STRCO) insertion element IS110 hypothetical 43.6 kDa protein from Streptomyces coelicolor. Contains Pfam match to entry PF01548 Transposase_9%2C Transposase. gene gene7844 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7782 SCO7783 SCO7783 SC5E9.31 SC5E9.31 8610407 8610638 + gene gene7845 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7783 SCO7784 SCO7784 SC5E9.32 SC5E9.32 8610851 8611627 + oxidoreductase SC5E9.32%2C possible oxidoreductase%2C len: 258aa%3B similar to many eg. SW:P39605 (NFRA_BACSU) nitro/flavin reductase from Bacillus subtilis (249 aa) fasta scores%3B opt: 426%2C z-score: 490.0%2C E(): 8e-20%2C 32.7%25 identity in 257 aa overlap. Contains Pfam match to entry PF00881 Nitroreductase%2C Nitroreductase family. gene gene7846 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7784 SCO7785 SCO7785 SC5E9.33 SC5E9.33 8611643 8612263 + transcriptional regulator SC5E9.33%2C possible transcriptional regulator%2C len: 206 aa%3B weakly similar to many eg. TR:Q9S250 (EMBL:AL096811) transcriptional regulator from Streptomyces coelicolor (213 aa) fasta scores%3B opt: 159%2C z-score: 199.4%2C E(): 0.0012%2C 25.7%25 identity in 171 aa overlap. Contains helix-turn-helix motif (Score 1164 (+3.15 SD)) at residue 33-54. Note possible alternative downstream start sites. gene gene7847 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7785 SCO7786 SCO7786 SC5E9.34c SC5E9.34c 8612498 8613085 - hypothetical protein SC5E9.34c%2C unknown%2C len: 195 aa%3B regions of weak similarity to transposases eg. TR:Q9RBZ3 (EMBL:AF169828) from Pseudomonas syringae (pv. glycinea) (357 aa) fasta scores%3B opt: 158%2C z-score: 201.5%2C E(): 0.00093%2C 26.7%25 identity in 135 aa overlap. gene gene7848 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7786 SCO7787 SCO7787 SC5E9.35c SC5E9.35c 8613473 8613841 - hypothetical protein SC5E9.35c%2C unknown%2C len: 122 aa gene gene7849 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7787 SCO7788 SCO7788 SC5E9.36c SC5E9.36c 8613848 8614045 - hypothetical protein SC5E9.36c%2C membrane protein%2C len: 65 aa. Contains possible hydrophobic membrane spanning regions gene gene7850 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7788 SCO7789 SCO7789 SC5E9.37c SC5E9.37c 8614151 8614369 - hypothetical protein SC5E9.37c%2C unknown%2C len: 72 aa gene gene7851 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7789 SCO7790 SCO7790 SC5E9.39c SC5E9.39c 8614384 8614620 - oxidoreductase SC5E9.39c%2C possible killer toxin-like protein%2C len: 78 aa%3B similar to SKLP (Streptomyces killer toxin-like protein) from Streptomyces sp. F-287 (Ohki et al. (2001) J. Mol. Biol. 305%2C 109-120). No TREMBL submission. Protein isolated from culture supernatent and shown to exhibit cytocidal effects on both budding and fission yeasts. gene gene7852 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7790 SCO7791 SCO7791 SC5E9.38c SC5E9.38c 8614845 8616050 - oxidoreductase SC5E9.38c%2C possible oxidoreductase%2C len: 401 aa%3B similar to many e.g. TR:O53772 (EMBL:AL021942) oxidoreductase from Mycobacterium tuberculosis (388 aa) fasta scores%3B opt: 524%2C z-score: 584.4%2C E(): 4.4e-25%2C 32.4%25 identity in 373 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. gene gene7853 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7791 SCO7791a SCO7791a SC10B8A.01c SC10B8A.01c 8616047 8617276 - oxidoreductase SC10B8A.01c%2C possible oxidoreductase%2C len: 409 aa%3B similar to TR:O53772 (EMBL:AL021942) oxidoreductase from Mycobacterium tuberculosis (388 aa) fasta scores%3B opt: 305%2C z-score: 305.8%2C E(): 1.5e-09%2C 31.6%25 identity in 358 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase%2C Monooxygenase. gene gene7854 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7791a SCO7792 SCO7792 SC10B8A.02c SC10B8A.02c 8617566 8617886 - hypothetical protein SC10B8A.02c%2C unknown%2C doubtful CDS%2C len: 106 aa gene gene7855 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7792 SCO7793 SCO7793 SC10B8A.03c SC10B8A.03c 8617943 8618245 - hypothetical protein SC10B8A.03c%2C unknown%2C doubtful CDS%2C len: 100 aa gene gene7856 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7793 SCO7794 SCO7794 SC10B8A.04 SC10B8A.04 8618313 8618951 + TetR family transcriptional regulator SC10B8A.04%2C possible TetR-family transcriptional regulator%2C len: 212 aa%3B similar to many e.g. SW:P03039 (TER3_ECOLI) tetracycline repressor protein class C from Escherichia coli (219 aa) fasta scores%3B opt: 358%2C z-score: 432.3%2C E(): 1.3e-16%2C 36.4%25 identity in 217 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif at residue 26-47 (Score 1166 (+3.16 SD)). gene gene7857 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7794 SCO7795 SCO7795 SC10B8A.05 SC10B8A.05 8618974 8619171 + transposase SC10B8A.05%2C transposase%2C partial CDS%2C len: 66aa%3B similar to TR:AAF31487 (EMBL:AF071515) transposase (fragment) from Streptomyces noursei (117 aa) fasta scores%3B opt: 339%2C z-score: 459.2%2C E(): 4.1e-18%2C 73.8%25 identity in 65 aa overlap. gene gene7858 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7795 SCO7796 SCO7796 SC10B8A.06 SC10B8A.06 8619410 8620069 + hypothetical protein SC10B8A.06%2C unknown%2C len: 219 aa%3B located between inverted DNA repeat units. gene gene7859 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7796 SCO7797 SCO7797 SC10B8A.07 SC10B8A.07 8620088 8620228 + transposase SC10B8A.07%2C possible transposase fragment%2C partial CDS%2C len: 46aa%3B similar to c-terminus of TR:O52240 (EMBL:AF109404) transposase from Streptomyces scabies (431 aa) fasta scores%3B opt: 80%2C z-score: 133.8%2C E(): 5.5%2C 42.5%25 identity in 40 aa overlap. Located between inverted DNA repeat units. gene gene7860 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7797 SCO7798 SCO7798 SC10B8A.08c SC10B8A.08c 8620339 8620857 - transposase SC10B8A.08c%2C possible transposase%2C len: 172aa%3B similar to many eg. TR:O69928 (EMBL:AL023861) transposase from Streptomyces coelicolor (152 aa) fasta scores%3B opt: 604%2C z-score: 704.2%2C E(): 9.3e-32%2C 62.7%25 identity in 150 aa overlap. Overlaps with neighbouring CDS SC10B8A.09c transposase. Contains TTA encoded leucine residue%2C possible target for bldA regulation. gene gene7861 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7798 SCO7799 SCO7799 SC10B8A.09c SC10B8A.09c 8620776 8621255 - transposase SC10B8A.09c%2C possible transposase%2C len: 159aa%3B similar to many eg. TR:O69927 (EMBL:AL023861) transposase from Streptomyces coelicolor (152 aa) fasta scores%3B opt: 400%2C z-score: 481.0%2C E(): 2.5e-19%2C 59.6%25 identity in 104 aa overlap. Contains Pfam match to entry PF01511 Transposase_6%2C Transposase. Overlaps with neighbouring CDS SC10B8A.08c transposase. gene gene7862 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7799 SCO7800 SCO7800 SC10B8A.10 SC10B8A.10 8621285 8621500 + hypothetical protein SC10B8A.10%2C unknown%2C doubtful CDS%2C len: 71 aa gene gene7863 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7800 SCO7801 SCO7801 SC10B8A.11 SC10B8A.11 8621520 8621900 + hypothetical protein SC10B8A.11%2C possible membrane protein%2C len: 126aa%3B contains possible membrane-spanning hydrophobic regions. gene gene7864 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7801 SCO7802 SCO7802 SC10B8A.12 SC10B8A.12 8622062 8623126 + gene gene7865 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7802 SCO7803 SCO7803 SC10B8A.13 SC10B8A.13 8623230 8624186 + insertion element transposase SC10B8A.13%2C possible insertion element transposase%2C len: 318aa%3B similar to many eg. TR:O86023 (EMBL:AF079817) transposase from plasmid pCS1 of Clavibacter michiganensis subsp. sepedonicus (320 aa) fasta scores%3B opt: 965%2C z-score: 1123.9%2C E(): 0%2C 50.6%25 identity in 316 aa overlap. Also identical to others from Streptomyces coelicolor eg. SCF41.27%2C TR:Q9RJU2 (EMBL:AL117387). Contains Pfam match to entry PF00665 rve%2C Integrase core domain. gene gene7866 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7803 SCO7804 SCO7804 SC10B8A.14 SC10B8A.14 8625198 8625431 + hypothetical protein SC8E7.01%2C possible membrane protein%2C partial CDS%2C len: >59 aa. Contains possible membrane spanning hydrophobic domains.~SC10B8A.14%2C unknown%2C len: 59aa gene gene7867 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7804 SCO7805 SCO7805 SC8E7.02 SC8E7.02 8625511 8625846 + hypothetical protein SC8E7.02%2C doubtful CDS%2C len: 111 aa. gene gene7868 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7805 SCO7806 SCO7806 SC8E7.03c SC8E7.03c 8626338 8627069 - DNA-binding protein SC8E7.03c%2C possible DNA-binding protein%2C len: 243 aa. Weakly similar to several including: Streptomyces ambofaciens protein of unknown function found within the SrmR regulatory locus TR:Q00510 (EMBL:X63451) SrmX (239 aa)%2C fasta scores opt: 167 z-score: 217.0 E(): 0.00013 30.9%25 identity in 220 aa overlap and Deinococcus radiodurans TR:Q9RTS7 (EMBL:AE002009) N-methyl-transferase-related protein (249 aa)%2C fasta scores opt: 160 z-score: 208.0 E(): 0.00041 27.1%25 identity in 214 aa overlap. Contains a helix-turn-helix motif situated between residues 60..81 (+3.06 SD). gene gene7869 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7806 SCO7807 SCO7807 SC8E7.04c SC8E7.04c 8627077 8627355 - hypothetical protein SC8E7.04c%2C unknown%2C len: 92 aa. Contains 2 TTA leucine codons%2C possible targets for bldA regulation gene gene7870 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7807 SCO7808 SCO7808 SC8E7.05c SC8E7.05c 8627358 8627651 - hypothetical protein SC8E7.05c%2C unknown%2C len: 97 aa. Highly similar to the N-terminal of Streptomyces coelicolor mini-circle transposase for IS11 SW:YM3_STRCO (EMBL:X15942) SC3C8.19 (414 aa)%2C fasta scores opt: 239 z-score: 303.4 E(): 2e-09 44.6%25 identity in 92 aa overlap. gene gene7871 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7808 SCO7809 SCO7809 SC8E7.06c SC8E7.06c 8628356 8628988 - TetR family transcriptional regulator SC8E7.06%2C possible TetR-family transcriptional regulator%2C len: 210 aa. Similar to several other members of the TetR-family e.g. Streptomyces glaucescens SW:TCMR_STRGA (EMBL:M80674) tetracenomycin C transcriptional repressor%2C TcmR (226 aa)%2C fasta scores opt: 187 z-score: 235.6 E(): 1.2e-05 26.4%25 identity in 197 aa overlap and Streptomyces coelicolor TR:CAB88457 (EMBL:AL353815) TetR-family transcriptional regulator%2C SCD6.28 (215 aa)%2C fasta scores opt: 239 z-score: 298.6 E(): 3.7e-09 32.0%25 identity in 178 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 36..57 (+5.84 SD). gene gene7872 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7809 SCO7810 SCO7810 SC8E7.07 SC8E7.07 8629040 8629804 + oxidoreductase SC8E7.07%2C possible oxidoreductase%2C len: 254 aa. Highly similar to many reductases e.g. Streptomyces coelicolor TR:O86853(EMBL:AJ007731) 3-ketoacyl-ACP/CoA reductase (244 aa)%2C fasta scores opt:777 z-score: 840.5 E():0 51.2%25 identity in 244 aa overlap. Contains a Pfam matches to entries PF00106 adh_short%2C short chain dehydrogenase and PF00678 adh_short_C2%2C Short chain dehydrogenase/reductase C-terminus. gene gene7873 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7810 SCO7811 SCO7811 SC8E7.08c SC8E7.08c 8630050 8630430 - hypothetical protein SC8E7.08c%2C possible membrane protein%2C len: 126 aa. Weakly similar to several e.g. Streptomyces coelicolor TR:Q9RJS0(EMBL:AL132707) probable integral membrane protein%2C SCF51.15C (201 aa)%2C fasta scores opt: 106 z-score: 142.5 E():1.8 33.7%25 identity in 104 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene7874 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7811 SCO7812 SCO7812 SC8E7.09c SC8E7.09c 8630427 8631386 - insertion element transposase SC8E7.09c%2C possible insertion element transposase%2C len: 319 aa. Highly similar to many e.g. Streptomyces coelicolor TR:Q9R319(EMBL:AL133236) IS470 transposase (275 aa)%2C fasta scores opt: 169 z-score: 203.4 E(): 0.00074 30.7%25 identity in 231 aa overlap. Contains a helix-turn-helix motif situated between residues 44..65 (+3.17 SD) and a TTA /leucine codon%2C possible target for bldA regulation. gene gene7875 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7812 SCO7813 SCO7813 SC8E7.10 SC8E7.10 8631557 8632408 + hypothetical protein SC8E7.10%2C unknown%2C len: 283 aa. Highly similar to multiple proteins of unknown function including: Mycobacterium tuberculosis TR:P96822 (EMBL:Z92770) hypothetical 34.3 kd protein (317 aa)%2C fasta scores: opt: 607 z-score: 740.2 E():0 39.1%25 identity in 284 aa overlap and Streptomyces coelicolor TR:Q9ZBH0 (EMBL:AL035206) SC9B5.10 (303 aa)%2C fasta scores: opt: 481 z-score: 587.9 E(): 2.9e-25 36.4%25 identity in 280 aa overlap gene gene7876 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7813 SCO7814 SCO7814 SC8E7.11c SC8E7.11c 8633882 8634802 - gene gene7877 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7814 SCO7815 SCO7815 SC8E7.12 SC8E7.12 8634816 8635487 + TetR family transcriptional regulator SC8E7.12 possible TetR-family transcriptional regulator%2C len: 223 aa. Highly similar to many regulators e.g. Mycobacterium tuberculosis TR:O53737 (EMBL:AL021932) transcriptional regulator (236 aa)%2C fasta scores opt: 471 z-score: 574.1 E(): 1.7e-24 39.0%25 identity in 218 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with a helix-turn-helix motif situated between residues 44..65 (+4.94 SD). gene gene7878 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7815 SCO7816 SCO7816 SC8E7.13 SC8E7.13 8635620 8636324 + hypothetical protein SC8E7.13%2C possible membrane protein%2C len: 234 aa. Weakly similar to several e.g. Staphylococcus aureus plasmid TR:O87368(EMBL:AF051917) membrane protein (248 aa)%2C fasta scores opt: 177 z-score: 205.1 E(): 0.0006 20.7%25 identity in 237 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene7879 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7816 SCO7817 SCO7817 SC8E7.14 SC8E7.14 8636400 8637242 - DNA-binding protein SC8E7.14%2C possible DNA-binding protein%2C len: 280 aa. Highly similar to many other DNA-binding proteins e.g. Streptomyces coelicolor TR:Q9S1Q8 (EMBL:AL109972) SCJ9A.12C (279 aa)%2C fasta scores opt: 946 z-score: 1117.2 E(): 0 54.1%25 identity in 268 aa overlap. Contains a helix-turn-helix motif situated between residues 131..153 (+3.68 SD) gene gene7880 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7817 SCO7818 SCO7818 SC8E7.15 SC8E7.15 8637359 8638123 + oxidoreductase SC8E7.15%2C possible oxidoreductase%2C len: 254 aa. Similar to several e.g. Escherichia coli SW:ENTA_ECOLI(EMBL:M24148) 2%2C3-dihydro-2%2C3-dihydroxybenzoate dehydrogenase (EC 1.3.1.28) (248 aa)%2C fasta scores opt: 253 z-score: 302.9 E(): 2.1e-09 32.0%25 identity in 197 aa overlap and Streptomyces coelicolor TR:Q9S1Q4(EMBL:AL109972) oxidoreductase%2C SCJ9A.16 (253 aa)%2C fasta scores opt: 622 z-score: 730.3 E(): 0 45.5%25 identity in 244 aa overlap. Contains a Prosite hit to PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase. gene gene7881 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7818 SCO7819 SCO7819 SC8E7.16c SC8E7.16c 8638588 8639436 - hypothetical protein SC8E7.16c%2C possible integral membrane protein%2C len: 282 aa. Similar to the several e.g. Myxococcus xanthus SW:GUFA_MYXXA(EMBL:X71062) integral membrane protein found within the carotenogenesis operon%2C GufA (254 aa)%2C fasta scores opt: 173 z-score: 197.7 E(): 0.001625.8%25 identity in 252 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7882 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7819 SCO7820 SCO7820 SC8E7.17 SC8E7.17 8639456 8639902 + hypothetical protein SC8E7.17%2C doubtful CDS%2C len: 148 aa. gene gene7883 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7820 SCO7821 SCO7821 SC8E7.18 SC8E7.18 8640037 8640450 + hypothetical protein SC8E7.18%2C possible integral membrane protein%2C len: 137 aa. Similar in parts to other Streptomyces coelicolor membrane proteins e.g. TR:O86735(EMBL:AL031035) SC3A9.03C (149 aa)%2C fasta scores opt: 148 z-score: 187.6 E(): 0.0056 35.9%25 identity in 103 aa overlap. Contains possible membrane spanning hydrophobic domains. gene gene7884 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7821 SCO7822 SCO7822 SC8E7.19c SC8E7.19c 8641685 8642638 - prolipoprotein diacylglyceryl transferase transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein gene gene7885 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7822 SCO7823 SCO7823 SC8E7.20c SC8E7.20c 8642714 8643124 - hypothetical protein SC8E7.20c%2C possible membrane protein%2C len: 136 aa. Contains possible membrane spanning hydrophobic domains. gene gene7886 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7823 SCO7824 SCO7824 SC8E7.21c SC8E7.21c 8643240 8643812 - TetR family transcriptional regulator SC8E7.21c%2C possible TetR-family transcriptional regulator%2C len: 190 aa. Similar to Deinococcus radiodurans TR:Q9RWE9 (EMBL:AE001928) transcriptional regulator%2C TetR family (215 aa)%2C fasta scores opt:245 z-score: 307.6 E(): 1.2e-09 33.3%25 identity in 168 aa overlap. Contains a Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family with the helix-turn-helix motif situated between residues 32..53 (+4.08 SD) gene gene7887 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7824 SCO7825 SCO7825 SC8E7.22 SC8E7.22 8643812 8644108 + hypothetical protein SC8E7.22%2C doubtful CDS%2C len: 98 aa. gene gene7888 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7825 SCO7826 SCO7826 SC8E7.23c SC8E7.23c 8644811 8645791 - hypothetical protein SC8E7.23c%2C unknown%2C len: 326 aa. gene gene7889 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7826 SCO7827 SCO7827 SC8E7.24c SC8E7.24c 8645888 8647537 - transposase SC8E7.24c%2C possible transposase%2C len: 549 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to the N-terminus of Streptomyces coelicolor TR:Q9S1X3(EMBL:AL109973) transposase (fragment)%2C SCJ30.16 (>398 aa) and to the C-terminus of Streptomyces coelicolor TR:Q9S1X2(EMBL:AL109950) transposase (fragment) SCJ4.01 (>183 aa). Note CDS SCJ30.16 and SCJ4.01 constitute the same CDS spanning the join of two adjacent cosmids. Also similar%2C in parts%2C to many other transposases e.g. Bordetella parapertussis SW:TRA1_BORPA(EMBL:X66858) transposase for insertion sequence element IS1001 (406 aa)%2C fasta scores opt: 203 z-score: 234.3 E(): 1.4e-05 28.4%25 identity in 215 aa overlap. Contains a helix-turn-helix motif situated between residues 308..329 (+4.27 SD) and a TTA leucine gene gene7890 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7827 SCO7828 SCO7828 SC8E7.25 SC8E7.25 8647737 8647991 + DNA-binding protein SC8E7.25%2C possible DNA-binding protein%2C len: 84 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X4 (EMBL:AL109973) hypothetical 9.0 kd protein%2C SCJ30.15C (84 aa). Contains a helix-turn-helix motif situated between residues 1..22 (+2.56 SD). gene gene7891 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7828 SCO7829 SCO7829 SC8E7.26 SC8E7.26 8648157 8649023 + hypothetical protein SC8E7.26%2C unknown%2C len: 288 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X5(EMBL:AL109973) hypothetical 31.6 kd protein%2C SCJ30.14C (288 aa). Also highly similar in regions to another Streptomyces coelicolor protein of undefined function: TR:Q9S1T4(EMBL:AL109950) SCJ4.39 (240 aa)%2C fasta scores opt: 334 z-score: 398.6 E(): 1e-14 41.6%25 identity in 245 aa overlap. gene gene7892 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7829 SCO7830 SCO7830 SC8E7.27c SC8E7.27c 8649245 8649589 - hypothetical protein SC8E7.27c%2C unknown%2C len: 114 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X6(EMBL:AL109973) hypothetical 12.2 kd protein%2C SCJ30.13 (114 aa). gene gene7893 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7830 SCO7831 SCO7831 SC8E7.28c SC8E7.28c 8649590 8649793 - hypothetical protein SC8E7.28c%2C unknown%2C len: 67 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X7(EMBL:AL109973) hypothetical 7.2 kd protein%2C SCJ30.12 (67 aa). gene gene7894 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7831 SCO7832 SCO7832 SC8E7.29 SC8E7.29 8650206 8651438 + Na+/H+ antiporter SC8E7.29%2C possible Na+/H+ antiporter%2C len: 410 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X8(EMBL:AL109973) Na+/H+ antiporter%2C SCJ30.11c (410 aa). Also highly similar to many other antiporters e.g. Haemophilus influenzae SW:NHAA_HAEIN(EMBL:U32708) Na(+)/H(+) antiporter 1 (400 aa)%2C fasta scores opt: 504 z-score: 559.3 E(): 1.1e-23 36.6%25 identity in 391 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. gene gene7895 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7832 SCO7833 SCO7833 SC8E7.30 SC8E7.30 8651913 8652191 + hypothetical protein SC8E7.30%2C unknown%2C len: 92 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1X9(EMBL:AL109973) hypothetical 10.0 kD protein%2C SCJ30.10C (92 aa). Also highly similar to another Streptomyces coelicolor protein of undefined function: TR:CAB88808(EMBL:AL353832) hypothetical 8.3 kd protein%2C SCE6.04 (75 aa)%2C fasta scores opt: 101 z-score: 157.4 E():0.27 32.1%25 identity in 81 aa overlap and the SCP1 plasmid borne TR:Q9ACW7 (EMBL:AL590464) conserved hypothetical protein SCP1.184%2C 92 aa%3B fasta scores: opt: 499 Z-score: 653.4 E(): 9.2e-29%3B 81.522%25 identity in 92 aa overlap. Contains a TTA leucine codon possible target for bldA regulation gene gene7896 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7833 SCO7834 SCO7834 SC8E7.31 SC8E7.31 8652479 8652769 + hypothetical protein SC8E7.31%2C unknown%2C len: 96 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y0(EMBL:AL109973) hypothetical 10.9 kd protein%2C SCJ30.09C (96 aa) gene gene7897 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7834 SCO7835 SCO7835 SC8E7.32 SC8E7.32 8653054 8653464 + hypothetical protein SC8E7.32%2C unknown%2C len: 136 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y2(EMBL:AL109973) hypothetical 15.5 kd protein%2C SCJ30.07c (136 aa). gene gene7898 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7835 SCO7836 SCO7836 SC8E7.33 SC8E7.33 8653485 8654294 + hypothetical protein SC8E7.33%2C unknown%2C len: 269 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y3(EMBL:AL109973) hypothetical protein%2C SCJ30.06c (269 aa). Note the large overlap with the adjoining CDS. gene gene7899 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7836 SCO7837 SCO7837 SC8E7.34c SC8E7.34c 8654051 8655142 - hypothetical protein SC8E7.34c%2C possible membrane protein%2C len: 363 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y4(EMBL:AL109973) hypothetical protein%2C SCJ30.05 (363 aa). Also similar to Streptomyces coelicolor TR:Q9X886(EMBL:AL049707) transferase%2C SCE15.11C (448 aa)%2C fasta scores opt: 411 z-score: 409.1 E(): 2.6e-15 32.8%25 identity in 274 aa overlap. Note the large overlap with the adjoining CDS. Contains possible membrane spanning hydrophobic domains and a TTA /leucine codon%2C possible target for bldA regulation. gene gene7900 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7837 SCO7838 SCO7838 SC8E7.35 SC8E7.35 8655556 8655891 + hypothetical protein SC8E7.35%2C unknown%2C len: 111 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y5(EMBL:AL109973) hypothetical protein%2C SCJ30.04c (111 aa). gene gene7901 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7838 SCO7839 SCO7839 SC8E7.36 SC8E7.36 8656148 8656498 + hypothetical protein SC8E7.36%2C unknown%2C len: 116 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y4(EMBL:AL109973) hypothetical protein%2C SCJ30.03c (116 aa). gene gene7902 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7839 SCO7840 SCO7840 SC8E7.37 SC8E7.37 8656508 8656954 + hypothetical protein SC8E7.37%2C unknown%2C len: 148 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y6 (EMBL:AL109973) hypothetical protein%2C SCJ30.02c (148 aa). gene gene7903 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7840 SCO7841 SCO7841 SC8E7.38c SC8E7.38c 8657098 8658204 - ATP/GTP-binding protein SC8E7.38c%2C possible ATP/GTP-binding protein%2C len: 368 aa. This CDS lies within a sequence duplicated at both ends of the Streptomyces coelicolor chromosome. Identical to Streptomyces coelicolor TR:Q9S1Y8(EMBL:AL109973) hypothetical protein (fragment)%2C SCJ30.01 (183 aa). Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene7904 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7841 SCO7842 SCO7842 SC8E7.39c SC8E7.39c 8658201 8660321 - transposase SC8E7.39c possible transposase%2C len: 706 aa. Similar to several including: Klebsiella aerogenes TR:Q48382(EMBL:X72585) probable transposase TnIA (559 aa)%2C fasta scores opt: 223 z-score: 248.4 E(): 2.3e-06 27.0%25 identity in 575 aa overlap and Streptomyces flavopersicus TR:Q9S1K8(EMBL:U70376) transposase homologue (679 aa)%2C fasta scores opt: 2570 z-score: 2862.5 E():0 57.4%25 identity in 700 aa overlap. gene gene7905 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7842 SCO7843 SCO7843 SC8E7.40c SC8E7.40c 8660335 8661282 - hypothetical protein SC8E7.40c%2C unknown%2C len: 315 aa. gene gene7906 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7843 SCO7844 SCO7844 SC8E7.41c SC8E7.41c 8661288 8663639 - DNA-binding protein SC8E7.41c%2C possible DNA-binding protein%2C len: 783 aa. Contains a helix-turn-helix motif situated between residues 69..90 (+3.17 SD). gene gene7907 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7844 SCO7845 SCO7845 SC8E7.42c SC8E7.42c 8663695 8666256 - hypothetical protein SCJ24.01c%2C unknown%2C partial CDS%2C len: >457 aa%3B strongly similar to TR:AAF36550 (EMBL:AF194023) helicase-like protein from Streptomyces lividans (881 aa) fasta scores%3B opt: 2191%2C z-score: 2490.1%2C E(): 0%2C 72.5%25 identity in 458 aa overlap.~SC8E7.42c%2C partial CDS%2C unknown%2C len:> 431 aa. Highly similar to Streptomyces lividans TR:AAF36550 (EMBL:AF194023) helicase-like protein found in the chromosome terminal region (881 aa)%2C fasta scores opt: 1940 z-score: 2170.3 E():0 66.9%25 identity in 438 aa overlap. gene gene7908 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7845 SCO7846 SCO7846 SCEND.02c SCEND.02c 8666385 8667062 - hypothetical protein SCEND.02c%2C unknown%2C doubtful CDS%2C len: 225 aa gene gene7909 http://www.ncbi.nlm.nih.gov/gene/?term=SCO7846 SCOp01 SCOp01 attB attB 5055612 5055771 + gene gene4680 http://www.ncbi.nlm.nih.gov/gene/?term=SCOp01 SCOr01 SCOr01 rrnC rrnC 1468591 1468710 - 5S ribosomal RNA 5S ribosomal RNA. Coordinates determined by comparison with Streptomyces griseus 16S ribosomal RNA (EMBL:M76388). rRNA gene1376 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr01 SCOr02 SCOr02 rrnC rrnC 1468795 1471916 - 23S ribosomal RNA 23S ribosomal RNA. Coordinates determined by comparison with Streptomyces griseus 16S ribosomal RNA (EMBL:M76388). rRNA gene1377 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr02 SCOr03 SCOr03 rrnC rrnC 1472193 1473723 - 16S ribosomal RNA 16S ribosomal RNA. Coordinates determined by comparison with Streptomyces griseus 16S ribosomal RNA (EMBL:M76388). rRNA gene1378 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr03 SCOr04 SCOr04 rrnB rrnB 1916451 1916571 - 5S ribosomal RNA probable 5S rRNA%2C coordinates taken from similarity to Streptomyces rimosus 5S rRNA gene of the rrnF gene set (EMBL:X62884) rRNA gene1789 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr04 SCOr05 SCOr05 rrnB rrnB 1916673 1919795 - 23S ribosomal RNA probable 23S rRNA%2C coordinates taken from similarity to Streptomyces rimosus 23S rRNA gene of the rrnF gene set (EMBL:X62884) rRNA gene1790 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr05 SCOr06 SCOr06 rrnB rrnB 1920072 1921599 - 16S ribosomal RNA probable 16S rRNA%2C coordinates taken from similarity to Streptomyces rimosus 16S rRNA gene of the rrnF gene set (EMBL:X62884) rRNA gene1791 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr06 SCOr07 SCOr07 SCOr07 3296634 3296750 - 5S ribosomal RNA probable 5S rRNA%2C coordinates taken from similarity to SW:SARRND (EMBL:M27245) Streptomyces ambifaciens rrnD gene cluster encoding 16S%2C 23S and 5S ribosomal RNAs rRNA gene3035 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr07 SCOr08 SCOr08 SCOr08 3296833 3300011 - 23S ribosomal RNA probable 23S rRNA%2C coordinates taken from similarity to SW:SARRND (EMBL:M27245) Streptomyces ambifaciens rrnD gene cluster encoding 16S%2C 23S and 5S ribosomal RNAs rRNA gene3036 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr08 SCOr09 SCOr09 SCOr09 3300208 3301965 - 16S ribosomal RNA probable 16S ribosomal RNA. Coodinates taken from similarity to SW:SARRND (EMBL:M27245) Streptomyces ambifaciens rrnD gene cluster encoding 16S%2C 23S and 5S ribosomal RNAs rRNA gene3037 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr09 SCOr10 SCOr10 rrnF rrnF 3685404 3685522 - 5S ribosomal RNA probable 5S rRNA%2C coordinates taken from similarity to Streptomyces rimosus 5S rRNA gene of the rrnF gene set (EMBL:X62884) rRNA gene3356 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr10 SCOr11 SCOr11 rrnF rrnF 3685606 3688729 - 23S ribosomal RNA probable 23S rRNA%2C coordinates taken from similarity to Streptomyces rimosus 23S rRNA gene of the rrnF gene set (EMBL:X62884) rRNA gene3357 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr11 SCOr12 SCOr12 rrnF rrnF 3689010 3690537 - 16S ribosomal RNA probable 16S rRNA%2C coordinates taken from similarity to Streptomyces coelicolor 16S rRNA gene of the rrnD gene set (EMBL:Y00411) rRNA gene3358 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr12 SCOr13 SCOr13 rrnA rrnA 4530650 4532177 + 16S ribosomal RNA rrnA%2C 16S ribosomal RNA. Coordinates based on comparison with rrnB from Streptomyces coelicolor (EMBL:AL109848). rRNA gene4166 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr13 SCOr14 SCOr14 rrnA rrnA 4532454 4535576 + 23S ribosomal RNA rrnA%2C 23S ribosomal RNA. Coordinates based on comparison with rrnB from Streptomyces coelicolor (EMBL:AL109848). rRNA gene4167 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr14 SCOr15 SCOr15 rrnA rrnA 4535678 4535798 + 5S ribosomal RNA rrnA%2C 5S ribosomal RNA. Coordinates based on comparison with rrnB from Streptomyces coelicolor (EMBL:AL109848). rRNA gene4168 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr15 SCOr16 SCOr16 rrnE rrnE 6269992 6271519 + 16S ribosomal RNA 16S rRNA gene%2C partial~16S rRNA gene%2C partial%2C approximate coordinates rRNA gene5805 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr16 SCOr17 SCOr17 rrnE rrnE 6271800 6274919 + 23S ribosomal RNA 23S rRNA gene%2C approximate coordinates rRNA gene5806 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr17 SCOr18 SCOr18 rrnE rrnE 6275003 6275121 + 5S ribosomal RNA 5S rRNA%2C approximate coordinates rRNA gene5807 http://www.ncbi.nlm.nih.gov/gene/?term=SCOr18 SCOs01 SCOs01 rnpB rnpB 2462887 2463312 - gene gene2293 http://www.ncbi.nlm.nih.gov/gene/?term=SCOs01 SCOs02 SCOs02 SCOs02 3226540 3226936 - gene gene2980 http://www.ncbi.nlm.nih.gov/gene/?term=SCOs02 SCOs03 SCOs03 srp srp 4457032 4457113 + gene gene4101 http://www.ncbi.nlm.nih.gov/gene/?term=SCOs03 SCOt01 SCOt01 SCOt01 1641943 1642017 - tRNA-Val tRNA Val anticodon CAC%2C Cove score 81.33 tRNA gene1524 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt01 SCOt02 SCOt02 SCOt02 1649559 1649633 - tRNA-Val tRNA Val anticodon CAC%2C Cove score 81.33 tRNA gene1530 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt02 SCOt03 SCOt03 glyUa glyUa 1656352 1656424 + tRNA-Gly tRNA Gly anticodon GCC%2C Cove score 84.38 tRNA gene1539 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt03 SCOt04 SCOt04 cysT cysT 1656463 1656536 + tRNA-Cys tRNA Cys anticodon GCA%2C Cove score 72.46 tRNA gene1540 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt04 SCOt05 SCOt05 vala vala 1656538 1656609 + tRNA-Val tRNA Val anticodon GAC%2C Cove score 79.08 tRNA gene1541 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt05 SCOt06 SCOt06 valb valb 1656646 1656717 + tRNA-Val tRNA Val anticodon GAC%2C Cove score 79.59 tRNA gene1542 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt06 SCOt07 SCOt07 valg valg 1656743 1656814 + tRNA-Val tRNA Val anticodon GAC%2C Cove score 79.08 tRNA gene1543 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt07 SCOt08 SCOt08 SCOt08 1797166 1797253 + tRNA-Leu tRNA Leu anticodon GAG%2C Cove score 65.31 tRNA gene1673 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt08 SCOt09 SCOt09 SCOt09 2155886 2155958 + tRNA-Leu tRNA Leu anticodon CAA%2C Cove score 48.90 tRNA gene2014 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt09 SCOt10 SCOt10 SCOt10 2523200 2523274 - tRNA-Val tRNA Val anticodon TAC%2C Cove score 85.35 tRNA gene2356 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt10 SCOt11 SCOt11 SCOt11 2646860 2646933 - tRNA-Met tRNA Met anticodon CAT%2C Cove score 87.30 tRNA gene2463 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt11 SCOt12 SCOt12 SCOt12 2647132 2647204 - tRNA-Asn tRNA Asn anticodon GTT%2C Cove score 77.32 tRNA gene2464 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt12 SCOt13 SCOt13 SCOt13 2647210 2647282 - tRNA-Asn tRNA Asn anticodon GTT%2C Cove score 77.41 tRNA gene2465 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt13 SCOt14 SCOt14 SCOt14 2781922 2781994 - tRNA-Ala tRNA Ala anticodon GGC%2C Cove score 82.18 tRNA gene2579 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt14 SCOt15 SCOt15 SCOt15 2782760 2782835 - tRNA-Ala tRNA Ala anticodon GGC%2C Cove score 82.80 tRNA gene2582 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt15 SCOt16 SCOt16 SCOt16 2847576 2847652 - tRNA-Pro tRNA Pro anticodon TGG%2C Cove score 86.37 tRNA gene2628 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt16 SCOt17 SCOt17 SCOt17 2847816 2847889 + tRNA-Gly tRNA Gly anticodon TCC%2C Cove score 78.23 tRNA gene2629 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt17 SCOt18 SCOt18 SCOt18 2929681 2929756 + tRNA-Arg tRNA Arg anticodon TCT%2C Cove score 79.17 tRNA gene2695 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt18 SCOt19 SCOt19 SCOt19 3049397 3049469 + tRNA-His tRNA His anticodon GTG%2C Cove score 71.04 tRNA gene2804 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt19 SCOt20 SCOt20 SCOt20 3079125 3079198 - tRNA-Lys tRNA Lys Anticodon CTT. Score 87.71 tRNA gene2830 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt20 SCOt21 SCOt21 SCOt21 3091827 3091900 + tRNA-Lys tRNA Lys anticodon CTT tRNA gene2845 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt21 SCOt22 SCOt22 SCOt22 3095139 3095215 + tRNA-Lys tRNA Lys anticodon CTT tRNA gene2849 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt22 SCOt23 SCOt23 SCOt23 3155187 3155273 + tRNA-Leu tRNA Leu anticodon TAG%2C Cove score 69.78 tRNA gene2915 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt23 SCOt24 SCOt24 bldA bldA 3380890 3380976 - tRNA-Leu tRNA Leu anticodon TAA (bldA)%2C Cove score 58.78 tRNA gene3106 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt24 SCOt25 SCOt25 SCOt25 3422227 3422299 + tRNA-OTHER tRNA Pseudo anticodon TTG%2C Cove score 42.02 tRNA gene3141 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt25 SCOt26 SCOt26 SCOt26 3481839 3481912 - tRNA-Ala tRNA Ala anticodon CGC%2C Cove score 77.02 tRNA gene3197 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt26 SCOt27 SCOt27 SCOt27 3602609 3602684 + tRNA-Arg tRNA Arg anticodon CCT%2C Cove score 77.93 tRNA gene3271 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt27 SCOt28 SCOt28 SCOt28 3908335 3908411 - tRNA-Thr tRNA Thr anticodon CGT%2C Cove score 80.05 tRNA gene3564 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt28 SCOt29 SCOt29 SCOt29 3963111 3963184 + tRNA-Pro tRNA Pro anticodon CGG%2C Cove score 80.14 tRNA gene3609 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt29 SCOt30 SCOt30 SCOt30 4062164 4062237 + tRNA-Gly tRNA Gly anticodon CCC%2C Cove score 80.37 tRNA gene3705 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt30 SCOt31 SCOt31 SCOt31 4226761 4226847 - tRNA-Leu tRNA Leu anticodon CAG%2C Cove score 67.20 tRNA gene3869 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt31 SCOt32 SCOt32 SCOt32 4243682 4243757 - tRNA-Ala tRNA Ala anticodon TGC%2C Cove score 77.32. tRNA gene3886 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt32 SCOt33 SCOt33 SCOt33 4259791 4259867 - tRNA-Ile tRNA Ile anticodon GAT%2C Cove score 97.97 tRNA gene3900 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt33 SCOt34 SCOt34 SCOt34 4382684 4382768 + tRNA-Ser tRNA Ser anticodon TGA%2C Cove score 60.95 tRNA gene4009 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt34 SCOt35 SCOt35 SCOt35 4407512 4407602 + tRNA-Ser tRNA Ser anticodon GCT%2C Cove score 61.85 tRNA gene4041 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt35 SCOt36 SCOt36 SCOt36 4407794 4407866 + tRNA-Arg tRNA Arg anticodon ACG%2C Cove score 72.28 tRNA gene4042 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt36 SCOt37 SCOt37 SCOt37 4433546 4433630 - tRNA-Ser tRNA Ser anticodon CGA%2C Cove score 55.75 tRNA gene4070 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt37 SCOt38 SCOt38 SCOt38 4456865 4456952 - tRNA-Ser tRNA Ser anticodon GGA%2C Cove score 72.31 tRNA gene4100 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt38 SCOt39 SCOt39 SCOt39 4465950 4466025 - tRNA-Gly tRNA Gly anticodon GCC%2C Cove score 89.80 tRNA gene4107 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt39 SCOt40 SCOt40 SCOt40 4469882 4469954 - tRNA-Gly tRNA Gly anticodon GCC%2C Cove score 84.38 tRNA gene4112 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt40 SCOt41 SCOt41 SCOt41 4486471 4486545 - tRNA-Asp tRNA Asp anticodon GTC%2C Cove score 68.25 tRNA gene4129 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt41 SCOt42 SCOt42 SCOt42 4490732 4490805 - tRNA-Phe tRNA Phe anticodon GAA%2C Cove score 78.93 tRNA gene4131 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt42 SCOt43 SCOt43 SCOt43 4490830 4490904 - tRNA-Asp tRNA Asp anticodon GTC%2C Cove score 68.25 tRNA gene4132 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt43 SCOt44 SCOt44 SCOt44 4490939 4491011 - tRNA-Glu tRNA Glu anticodon TTC%2C Cove score 63.59 tRNA gene4133 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt44 SCOt45 SCOt45 SCOt45 4498149 4498221 + tRNA-Lys tRNA Lys anticodon TTT%2C Cove score 82.40 tRNA gene4139 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt45 SCOt46 SCOt46 SCOt46 4505460 4505533 + tRNA-Met tRNA Met anticodon CAT%2C Cove score 71.40 tRNA gene4149 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt46 SCOt47 SCOt47 SCOt47 4646531 4646607 + tRNA-Thr tRNA Thr anticodon TGT%2C Cove score 77.78 tRNA gene4287 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt47 SCOt48 SCOt48 SCOt48 5038512 5038593 + tRNA-Tyr tRNA Tyr anticodon GTA%2C Cove score 63.32 tRNA gene4662 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt48 SCOt49 SCOt49 SCOt49 5061316 5061388 + tRNA-Thr tRNA Thr anticodon GGT%2C Cove score 79.07 tRNA gene4684 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt49 SCOt50 SCOt50 SCOt50 5061435 5061507 + tRNA-Met tRNA Met anticodon CAT%2C Cove score 77.46 tRNA gene4685 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt50 SCOt51 SCOt51 SCOt51 5071215 5071290 + tRNA-Trp tRNA Trp anticodon CCA %2C Cove score 79.13 tRNA gene4697 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt51 SCOt52 SCOt52 SCOt52 5664562 5664635 + tRNA-Met tRNA Met anticodon CAT%2C Cove score 79.35 tRNA gene5257 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt52 SCOt53 SCOt53 SCOt53 5666820 5666893 - tRNA-Met tRNA Met anticodon CAT%2C Cove score 79.35 tRNA gene5259 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt53 SCOt54 SCOt54 SCOt54 5797608 5797677 - tRNA-OTHER tRNA Pseudo anticodon CCG%2C Cove score 20.64 tRNA gene5381 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt54 SCOt55 SCOt55 SCOt55 5818721 5818795 - tRNA-Arg tRNA Arg anticodon CCG%2C Cove score 77.44 tRNA gene5405 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt55 SCOt56 SCOt56 SCOt56 6049148 6049219 + tRNA-Gln tRNA Gln anticodon CTG%2C Cove score 58.49 tRNA gene5605 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt56 SCOt57 SCOt57 SCOt57 6049259 6049331 + tRNA-Glu tRNA Glu anticodon CTC%2C Cove score 63.89 tRNA gene5606 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt57 SCOt58 SCOt58 SCOt58 6049394 6049469 + tRNA-Glu tRNA Glu anticodon CTC%2C Cove score 64.51 tRNA gene5607 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt58 SCOt59 SCOt59 SCOt59 6049487 6049558 + tRNA-Gln tRNA Gln anticodon CTG%2C Cove score 57.02 tRNA gene5608 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt59 SCOt60 SCOt60 SCOt60 6049603 6049675 + tRNA-Glu tRNA Glu anticodon CTC%2C Cove score 63.89 tRNA gene5609 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt60 SCOt61 SCOt61 SCOt61 6275983 6276058 + tRNA-Thr tRNA Thr%3B anticodon GGT tRNA gene5809 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt61 SCOt62 SCOt62 SCOt62 7300604 7300688 + tRNA-Leu tRNA Leu%3B anticodon GAG tRNA gene6649 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt62 SCOt63 SCOt63 SCOt63 7565958 7566031 + tRNA-Pro tRNA Pro anticodon GGG%2C Cove score 78.36 tRNA gene6867 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt63 SCOt64 SCOt64 SCOt64 7740493 7740566 + tRNA-Pro tRNA Pro anticodon GGG%2C Cove score 78.36 tRNA gene7034 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt64 SCOt65 SCOt65 SCOt65 7759229 7759302 + tRNA-Pro tRNA Pro anticodon GGG%2C Cove score 78.36 tRNA gene7054 http://www.ncbi.nlm.nih.gov/gene/?term=SCOt65 SCP1.01c SCP1.01c SCP1.01c 899 1522 - hypothetical protein unknown%2C len: 207aa gene gene7910 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.01c SCP1.02c SCP1.02c SCP1.02c 1607 2812 - hypothetical protein unknown%2C len: 401aa gene gene7911 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.02c SCP1.03c SCP1.03c SCP1.03c 2903 3121 - hypothetical protein unknown%2C len: 72aa gene gene7912 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.03c SCP1.04c SCP1.04c SCP1.04c 3109 3345 - hypothetical protein unknown%2C len: 78aa gene gene7913 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.04c SCP1.05c SCP1.05c SCP1.05c 3424 3819 - hypothetical protein unknown%2C len: 131aa gene gene7914 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.05c SCP1.06c SCP1.06c SCP1.06c 4408 4632 - hypothetical protein unknown%2C len: 74aa gene gene7915 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.06c SCP1.07c SCP1.07c SCP1.07c 4629 4922 - hypothetical protein unknown%2C len: 97aa gene gene7916 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.07c SCP1.08c SCP1.08c SCP1.08c 4919 5440 - hypothetical protein unknown%2C len: 173aa gene gene7917 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.08c SCP1.09c SCP1.09c SCP1.09c 5516 6181 - hypothetical protein unknown%2C len: 221aa gene gene7918 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.09c SCP1.10 SCP1.10 SCP1.10 6777 7271 + hypothetical protein unknown%2C contains TTA encoded leucine at residue 33%2C possible target for bldA regulation. len: 164aa gene gene7919 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.10 SCP1.100 SCP1.100 SCP1.100 96676 99111 + atp/GTP-binding gly/ala-rich protein possible ATP/GTP-binding Gly/Ala-rich protein%2C len: 811aa%3B contains possible coiled-coil region at 428-444 residues. Also contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8008 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.100 SCP1.101 SCP1.101 traB traB 99127 99540 + plasmid transfer protein possible plasmid transfer protein%2C len: 137aa%3B similar to TR:Q06257 (EMBL:X72857) TraB protein from plasmid SCP2 of Streptomyces coelicolor (137 aa) fasta scores%3B opt: 142%2C z-score: 180.4%2C E(): 0.014%2C 29.4%25 identity in 136 aa overlap. Contains possible coiled-coil region at 26-39 residues. gene gene8009 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.101 SCP1.102 SCP1.102 traA traA 99624 101732 + plasmid transfer protein%2C (atp/GTP-binding) possible plasmid transfer protein%2C (ATP/GTP-binding)%2C len: 702aa%3B regions of similarity to proteins from other streptomycete plasmids. N-terminal similar to TR:Q07193 (EMBL:Z19593) SpdA protein from plasmid pSAM2 of Streptomyces ambofaciens (224 aa) blastp scores: Identities %3D 32/84 (38%25)%2C Positives %3D 38/84 (45%25). C-terminal region similar to TR:Q06256 (EMBL:X72857) TraA protein from plasmid SCP2 of Streptomyces coelicolor (442 aa) blastp scores: Identities %3D 73/285 (25%25)%2C Positives %3D 130/285 (45%25). Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8010 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.102 SCP1.103 SCP1.103 SCP1.103 102063 102596 + hypothetical protein unknown%2C len: 177aa%3B weakly similar to TR:Q9L158 (EMBL:AL158060) hypothetical protein from Streptomyces coelicolor (132 aa) fasta scores%3B opt: 125%2C z-score: 165.0%2C E(): 0.1%2C 33.3%25 identity in 129 aa overlap. gene gene8011 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.103 SCP1.104 SCP1.104 SCP1.104 102859 103323 + hypothetical protein unknown%2C len: 154aa%3B weakly similar to SW:P71686 (YE17_MYCTU) fasta scores%3B opt: 113%2C z-score: 145.5%2C E(): 1.2%2C 33.6%25 identity in 107 aa overlap. gene gene8012 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.104 SCP1.105 SCP1.105 SCP1.105 103344 103805 + integral membrane plasmid transfer protein possible integral membrane plasmid transfer protein%2C len: 153aa%3B similar to TR:Q57241 (EMBL:U23762) SpbB3 protein (involved in intramycelial plasmid spread) from plasmid pJV1 of Streptomyces phaeochromogenes (147 aa) fasta scores%3B opt: 317%2C z-score: 394.0%2C E(): 1.8e-14%2C 46.5%25 identity in 142 aa overlap. gene gene8013 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.105 SCP1.106 SCP1.106 SCP1.106 103846 104439 + hypothetical protein unknown%2C len: 197aa gene gene8014 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.106 SCP1.107 SCP1.107 SCP1.107 104552 104935 + hypothetical protein unknown%2C len: 127aa gene gene8015 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.107 SCP1.108 SCP1.108 SCP1.108 105204 105809 + hypothetical protein unknown%2C len: 201aa gene gene8016 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.108 SCP1.109 SCP1.109 SCP1.109 105806 105997 + hypothetical protein unknown%2C len: 63aa gene gene8017 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.109 SCP1.110 SCP1.110 SCP1.110 105994 106995 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 333aa%3B N-terminal similar to that of TR:O69213 (EMBL:AJ224354) protein serine-threonine phosphatase from Anabaena sp. (strain PCC 7120) (858 aa) fasta scores%3B opt: 334%2C z-score: 391.4%2C E(): 2.5e-14%2C 42.0%25 identity in 150 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8018 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.110 SCP1.111 SCP1.111 SCP1.111 106992 107186 + hypothetical protein doubtful CDS%2C unknown%2C len: 64aa gene gene8019 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.111 SCP1.112 SCP1.112 SCP1.112 107224 107994 + hypothetical protein unknown%2C len: 256aa gene gene8020 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.112 SCP1.113 SCP1.113 SCP1.113 108078 108845 + hypothetical protein unknown%2C len: 255aa%3B contains a region conserved in other proteins eg. SW:P36892 (YREP_STRAM) hypothetical 19.3 kDa protein in RepSA 5'region (ORF183) from plasmid pSAM2 of Streptomyces ambofaciens%2C possibly involved in control of plasmid replication (183 aa) fasta scores%3B opt: 458%2C z-score: 523.4%2C E(): 1.1e-21%2C 47.7%25 identity in 174 aa overlap. Contains Pfam match to entry PF00990 DUF9%2C Domain of unknown function DUF9. gene gene8021 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.113 SCP1.114 SCP1.114 SCP1.114 108842 109300 + hypothetical protein unknown%2C len: 152aa gene gene8022 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.114 SCP1.115 SCP1.115 SCP1.115 109297 109824 + hypothetical protein unknown%2C len: 175aa%3B weak similarity with TR:Q9Z6E9 (EMBL:AF073300) WhiB%2C regulatory protein from Mycobacterium smegmatis (96 aa) fasta scores%3B opt: 118%2C z-score: 151.2%2C E(): 0.59%2C 28.9%25 identity in 97 aa overlap. gene gene8023 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.115 SCP1.116 SCP1.116 SCP1.116 110011 111153 + ecf family sigma factor possible ECF-family sigma factor%2C len: 380aa%3B region similar to many eg. TR:Q9RIT1 (EMBL:AJ010584) ECF sigma factor from Streptomyces coelicolor (264 aa) fasta scores%3B opt: 485%2C z-score: 519.3%2C E(): 1.9e-21%2C 39.0%25 identity in 223 aa overlap and SW:P35165 (SIGX_BACSU) RNA polymerase sigma factor SigX from Bacillus subtilis (194 aa) fasta scores%3B opt: 215%2C z-score: 237.7%2C E(): 9e-06%2C 29.0%25 identity in 162 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF%2C Sigma-70 factor (ECF subfamily). Contains a TTA encoded leucine at residue 31%2C possible target for bldA regulation. gene gene8024 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.116 SCP1.117 SCP1.117 SCP1.117 111150 111905 + hypothetical protein unknown%2C len: 251aa gene gene8025 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.117 SCP1.118 SCP1.118 SCP1.118 112041 112220 + hypothetical protein doubtful CDS%2C unknown%2C len: 59aa gene gene8026 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.118 SCP1.119 SCP1.119 dnaN dnaN 112312 113430 + DNA polymerase III subunit beta binds the polymerase to DNA and acts as a sliding clamp gene gene8027 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.119 SCP1.11c SCP1.11c SCP1.11c 7395 8138 - hypothetical protein unknown%2C len: 247aa gene gene7920 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.11c SCP1.120 SCP1.120 SCP1.120 113446 113625 + hypothetical protein unknown%2C len: 59aa gene gene8028 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.120 SCP1.121 SCP1.121 SCP1.121 113740 114735 + hypothetical protein unknown%2C len: 178aa%3B Contains a TTA encoded leucine at residue 76%2C possible target for bldA regulation. gene gene8029 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.121 SCP1.122 SCP1.122 SCP1.122 114800 115540 + hypothetical protein unknown%2C len: 246aa%3B regions similar to other proteins of undefined function eg. SW:P71690 (YE21_MYCTU) hypothetical protein from Mycobacterium tuberculosis (301 aa) fasta scores%3B opt: 194%2C z-score: 231.0%2C E(): 2.1e-05%2C 36.4%25 identity in 132 aa overlap. gene gene8030 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.122 SCP1.123 SCP1.123 SCP1.123 115634 115759 + hypothetical protein doubtful CDS%2C unknown%2C len: 41aa gene gene8031 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.123 SCP1.124c SCP1.124c SCP1.124c 115803 116042 - hypothetical protein unknown%2C len: 79aa gene gene8032 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.124c SCP1.125 SCP1.125 SCP1.125 116467 118641 + hypothetical protein unknown%2C len: 724aa gene gene8033 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.125 SCP1.126 SCP1.126 SCP1.126 118650 118886 + hypothetical protein unknown%2C len: 78aa gene gene8034 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.126 SCP1.127 SCP1.127 SCP1.127 118883 119662 + hypothetical protein unknown%2C len: 259aa gene gene8035 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.127 SCP1.128 SCP1.128 SCP1.128 120071 120868 + hypothetical protein unknown%2C len: 265aa%3B Contains a TTA encoded leucine at residue 43%2C possible target for bldA regulation. gene gene8036 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.128 SCP1.129 SCP1.129 SCP1.129 120868 121305 + hypothetical protein unknown%2C len: 145aa gene gene8037 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.129 SCP1.12c SCP1.12c SCP1.12c 8135 8590 - hypothetical protein doubtful CDS%2C unknown%2C len: 151aa gene gene7921 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.12c SCP1.130 SCP1.130 SCP1.130 121302 121631 + hypothetical protein unknown%2C len: 109aa gene gene8038 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.130 SCP1.131 SCP1.131 SCP1.131 121863 122663 + hypothetical protein unknown%2C len: 266aa gene gene8039 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.131 SCP1.132c SCP1.132c SCP1.132c 122807 123343 - hypothetical protein unknown%2C len: 178aa gene gene8040 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.132c SCP1.133 SCP1.133 SCP1.133 123685 123936 + hypothetical protein doubtful CDS%2C unknown%2C len: 83aa gene gene8041 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.133 SCP1.134 SCP1.134 SCP1.134 123923 124249 + hypothetical protein unknown%2C len: 108aa gene gene8042 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.134 SCP1.135 SCP1.135 SCP1.135 124246 125187 + hypothetical protein unknown%2C len: 313aa gene gene8043 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.135 SCP1.136 SCP1.136 SCP1.136 125272 127911 + helicase possible helicase%2C len: 879aa%3B similar to other large proteins eg. TR:Q9L8V8 (EMBL:AF194023) helicase-like protein (881 aa) fasta scores%3B opt: 377%2C z-score: 397.0%2C E(): 1.2e-14%2C 37.2%25 identity in 916 aa overlap. Contains Pfam match to entry PF00271 helicase_C%2C Helicases conserved C-terminal domain. Note that this protein is inverted and repeated at complement(215655..217487) CDS SCP1.216Ac fasta scores%3B opt: 3788%2C z-score: 3530.0%2C E(): 0%2C 93.0%25 identity in 599 aa overlap. SCP1.216Ac is truncated at the N-terminus suggesting that either SCP1.216Ac is deleted or SCP1.136 has an incorrectly designated translational start site.%3B label: helicase? gene gene8044 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.136 SCP1.137c SCP1.137c SCP1.137c 128413 128709 - hypothetical protein doubtful CDS%2C unknown%2C len: 98aa gene gene8045 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.137c SCP1.138 SCP1.138 parA1 parA1 128828 130090 + plasmid partitioning protein%2C para1 parA1%2C possible plasmid partitioning protein%2C len: 420aa%3B similar to many eg. TR:Q9RFM1 (EMBL:AF187159) ParA partitioning protein from Streptomyces coelicolor (357 aa) fasta scores%3B opt: 185%2C z-score: 214.7%2C E(): 0.00017%2C 29.0%25 identity in 314 aa overlap. Contains Pfam match to entry PF00991 ParA%2C ParA family ATPase. This CDS is directly duplicated at 221485..222648 (ParA2%2C SCP1.221) fasta scores%3B opt: 980%2C z-score: 1089.9%2C E(): 0%2C 55.2%25 identity in 424 aa overlap. gene gene8046 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.138 SCP1.139 SCP1.139 parB1 parB1 130087 131214 + plasmid partitioning protein%2C parb1 parB1%2C plasmid probable partitioning protein%2C len: 375aa%3B weakly similar to many ParB-like proteins eg. TR:Q9RFM2 (EMBL:AF187159) ParB partitioning protein from Streptomyces coelicolor (368 aa) fasta scores%3B opt: 176%2C z-score: 188.6%2C E(): 0.0049%2C 32.3%25 identity in 192 aa overlap. Contains Pfam match to entry PF02195 ParBc%2C ParB-like nuclease domain. This CDS is directly duplicated at 130087..131214 (ParB2%2C SCP1.222) fasta scores%3B opt: 566%2C z-score: 524.0 E(): 1.2e-24%2C 33.6%25 identity in 384 aa overlap. gene gene8047 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.139 SCP1.13c SCP1.13c SCP1.13c 8633 10249 - hypothetical protein conserved hypothetical protein%2C len: 538aa%3B C-terminal similar to TR:Q9KXL1 (EMBL:AL357524) hypothetical protein from Streptomyces coelicolor (282 aa) fasta scores%3B opt: 682%2C z-score: 810.6%2C E(): 0%2C 51.1%25 identity in 235 aa overlap. Contains TTA encoded leucine at residue 154%2C possible target for bldA regulation. gene gene7922 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.13c SCP1.140 SCP1.140 SCP1.140 131476 133197 + hypothetical protein possible membrane protein%2C len: 573aa%3B N-terminal half contains possible membrane-spanning hydrophobic regions and is strongly similar to the N-terminal region of of TR:Q9X894 (EMBL:AL049707) integral membrane protein from Streptomyces coelicolor (433 aa) fasta scores%3B opt: 1482%2C z-score: 1388.5%2C E(): 0%2C 62.4%25 identity in 420 aa overlap. gene gene8048 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.140 SCP1.141 SCP1.141 SCP1.141 133878 134771 + hypothetical protein unknown%2C len: 297aa gene gene8049 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.141 SCP1.142 SCP1.142 SCP1.142 134811 135074 + hypothetical protein unknown%2C len: 87aa gene gene8050 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.142 SCP1.143 SCP1.143 SCP1.143 135071 136180 + hypothetical protein possible membrane protein%2C len: 369aa%3B contains one possible membrane-spanning hydrophobic region. gene gene8051 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.143 SCP1.144 SCP1.144 SCP1.144 136187 136474 + hypothetical protein possible membrane protein%2C len: 95aa%3B contains two possible membrane-spanning hydrophobic regions. gene gene8052 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.144 SCP1.145 SCP1.145 SCP1.145 136471 137070 + hypothetical protein possible membrane protein%2C len: 199aa%3B contains two possible membrane-spanning hydrophobic regions. gene gene8053 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.145 SCP1.146 SCP1.146 SCP1.146 137070 139616 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 848aa%3B weak but full length similarity with TR:Q9L4H0 (EMBL:AJ243106) conjugative protein from integrative element ICESt1 of Streptococcus thermophilus (834 aa) fasta scores%3B opt: 190%2C z-score: 212.3%2C E(): 0.00023%2C 18.6%25 identity in 870 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8054 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.146 SCP1.147 SCP1.147 SCP1.147 139613 141931 + integral membrane protein possible integral membrane protein%2C len: 772aa%3B contains multiple possible membrane-spanning hydrophobic regions. Note possible alternative downstream translational start sites. Proline-rich C-terminal region. gene gene8055 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.147 SCP1.148 SCP1.148 SCP1.148 141924 143078 + secreted protein possible secreted protein%2C len: 384aa%3B similar to many especially TR:Q9L1N1 (EMBL:AL138977) secreted protein from Streptomyces coelicolor (377 aa) fasta scores%3B opt: 1234%2C z-score: 1291.1%2C E(): 0%2C 52.2%25 identity in 385 aa overlap. Contains a possible cleavable N-terminal signal sequence. Also contains Pfam match to entry PF00877 NLPC_P60%2C NLP/P60 family. gene gene8056 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.148 SCP1.149c SCP1.149c SCP1.149c 143167 144276 - hypothetical protein unknown%2C len: 369aa%3B similar to SCP1.181c (pseudogene) fasta scores%3B opt: 331%2C z-score: 405.0%2C E(): 4.9e-18%2C 44.2%25 identity in 120 aa overlap. gene gene8057 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.149c SCP1.14c SCP1.14c SCP1.14c 10282 11430 - hypothetical protein unknown%2C len: 382aa gene gene7923 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.14c SCP1.15 SCP1.15 SCP1.15 11690 11914 + hypothetical protein possible membrane protein%2C len: 74aa%3B contains possible membrane-spanning hydrophobic regions. gene gene7924 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.15 SCP1.150c SCP1.150c SCP1.150c 144552 145661 - hypothetical protein unknown%2C len: 369aa gene gene8058 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.150c SCP1.151c SCP1.151c SCP1.151c 145658 146182 - sigma factor possible sigma factor%2C len: 174aa%3B weakly similar to many eg. TR:Q9X8Z1 (EMBL:AL078610) ECF sigma factor from Streptomyces coelicolor (184 aa) fasta scores%3B .opt: 187%2C z-score: 235.0%2C E(): 1.3e-05%2C 28.0%25 identity in 164 aa overlap and TR:O05767 (EMBL:U87307) SigE%2C extracytoplasmic function alternative sigma factor from Mycobacterium smegmatis (204 aa) fasta scores%3B opt: 160%2C z-score: 202.2%2C E(): 0.00085%2C 27.8%25 identity in 187 aa overlap. gene gene8059 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.151c SCP1.152 SCP1.152 SCP1.152 146399 146851 + hypothetical protein unknown%2C len: 150aa gene gene8060 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.152 SCP1.153 SCP1.153 SCP1.153 147330 147803 + secreted protein possible secreted protein%2C len: 157aa%3B contains a possible N-terminal signal sequence. gene gene8061 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.153 SCP1.154 SCP1.154 SCP1.154 147800 149980 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 726aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8062 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.154 SCP1.155 SCP1.155 SCP1.155 149995 150951 + hypothetical protein unknown%2C len: 318aa gene gene8063 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.155 SCP1.156 SCP1.156 SCP1.156 150948 151241 + hypothetical protein unknown%2C len: 97aa gene gene8064 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.156 SCP1.157 SCP1.157 SCP1.157 151267 151653 + hypothetical protein unknown%2C len: 128aa gene gene8065 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.157 SCP1.158 SCP1.158 SCP1.158 152373 153824 + hypothetical protein unknown%2C len: 483aa gene gene8066 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.158 SCP1.159c SCP1.159c SCP1.159c 153834 154043 - oxidoreductase subunit possible oxidoreductase subunit%2C len: 90aa%3B similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. SW:P37606 (GPDA_ECOLI) glycerol-3-phosphate dehydrogenase from Escherichia coli (339 aa) fasta scores%3B opt: 176%2C z-score: 239.8 E(): 6.9e-06%2C 39.5%25 identity in 76 aa overlap and TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores%3B opt: 252%2C z-score: 338.2%2C E(): 2.3e-11%2C 53.1%25 identity in 81 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores%3B opt: 238%2C z-score: 294.0%2C E(): 7.6e-12%2C 50.7%25 identity in 75 aa overlap. gene gene8067 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.159c SCP1.160c SCP1.160c SCP1.160c 154161 155738 - oxidoreductase possible oxidoreductase%2C len: 525aa%3B similar to many eg. TR:Q9RDL3 (EMBL:AL136518) oxidoreductase from Streptomyces coelicolor (524 aa) fasta scores%3B opt: 308%2C1 z-score: 3329.1%2C E(): 0%2C 88.9%25 identity in 523 aa overlap and SW:P56913 (NUF2_RHIME) NADH dehydrogenase I chain F 2 (EC 1.6.5.3) from Rhizobium meliloti (Sinorhizobium meliloti) (421 aa) fasta scores%3B opt: 367%2C z-score: 400.3%2C E(): 7.9e-15%2C 28.4%25 identity in 395 aa overlap. gene gene8068 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.160c SCP1.161c SCP1.161c SCP1.161c 156182 156988 - regulatory protein possible regulatory protein%2C len: 268aa%3B regions similar to many regulatory proteins eg. N-terminus similar to TR:Q9S2B9 (EMBL:AL079353) regulatory protein from Streptomyces coelicolor (112 aa) blastp scores%3B Identities %3D 50/89 (56%25)%2C Positives %3D 60/89 (67%25) and C-terminal region similar to SW:P38133 (RPOE_STRCO) SigE%2C RNA polymerase sigma-E factor from Streptomyces coelicolor (176 aa) blastp scores%3B Identities %3D 36/131 (27%25)%2C Positives %3D 62/131 (47%25). Contains TTA encoded leucine at residue 70%2C possible target for bldA regulation. gene gene8069 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.161c SCP1.162c SCP1.162c SCP1.162c 157452 157649 - oxidoreductase subunit possible oxidoreductase subunit%2C len: 65aa%3B similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores%3B opt: 302%2C z-score: 432.6%2C E(): 1.3e-16%2C 76.9%25 identity in 65 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores%3B opt: 238%2C z-score: 294.0%2C E(): 7.6e-12%2C 50.7%25 identity in 75 aa overlap. gene gene8070 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.162c SCP1.163 SCP1.163 SCP1.163 157992 159116 + transposase probable transposase%2C len: 374aa%3B similar to many eg. TR:Q9KXL3 (EMBL:AL357524) transposase from Streptomyces coelicolor (281 aa) fasta scores%3B opt: 1663%2C z-score: 1992.2%2C E(): 0%2C 85.4%25 identity in 280 aa overlap and TR:Q44454 (EMBL:Z18270) transposase from IS870 of Agrobacterium tumefaciens (366 aa) fasta scores%3B opt: 248%2C z-score: 300.2%2C E(): 3e-09%2C 24.1%25 identity in 340 aa overlap. Contains Pfam match to entry PF00665 rve%2C Integrase core domain. Contains a TTA encoded leucine at residue 139%2C possible target for bldA regulation. Overlaps region covered by an inverted repeat (158060..158081 and 159583..159604). gene gene8071 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.163 SCP1.164c SCP1.164c SCP1.164c 159899 160291 - hypothetical protein unknown%2C len: 130aa%3B similar to TR:O68053 (EMBL:AF010496) hypothetical protein from Rhodobacter capsulatus (139 aa) fasta scores%3B opt: 223%2C z-score: 291.8%2C E(): 8.7e-09%2C 38.9%25 identity in 126 aa overlap. gene gene8072 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.164c SCP1.165 SCP1.165 SCP1.165 160942 161544 + secreted protein/lipoprotein possible secreted protein/lipoprotein%2C len: 200aa%3B contains a possible cleavable N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. gene gene8073 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.165 SCP1.166 SCP1.166 SCP1.166 161538 162440 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 300aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8074 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.166 SCP1.167 SCP1.167 SCP1.167 162487 163170 + hypothetical protein possible membrane protein%2C len: 227aa%3B weakly similar to TR:Q9L0S0 (EMBL:AL160312) hypothetical protein from Streptomyces coelicolor (239 aa) fasta scores%3B opt: 202%2C z-score: 221.4%2C E(): 7.3e-05%2C 27.2%25 identity in 235 aa overlap. Note possible alternative downstream start codons. gene gene8075 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.167 SCP1.168 SCP1.168 SCP1.168 163174 164052 + hypothetical protein unknown%2C len: 292aa%3B similar to TR:Q9L0R9 (EMBL:AL160312) hypothetical protein from Streptomyces coelicolor (293 aa) fasta scores%3B opt: 262%2C z-score: 304.0%2C E(): 1.8e-09%2C 30.3%25 identity in 300 aa overlap. gene gene8076 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.168 SCP1.169 SCP1.169 SCP1.169 164045 165658 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 537aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8077 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.169 SCP1.16c SCP1.16c SCP1.16c 12362 12946 - hypothetical protein unknown%2C len: 194aa gene gene7925 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.16c SCP1.17 SCP1.17 SCP1.17 13089 13907 + hypothetical protein unknown%2C len: 272aa gene gene7926 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.17 SCP1.170 SCP1.170 SCP1.170 165702 166694 + integral membrane protein possible integral membrane protein%2C len: 330aa%3B similar to TR:Q9L0R7 (EMBL:AL160312) integral membrane protein from Streptomyces coelicolor (345 aa) fasta scores%3B opt: 385%2C z-score: 452.0%2C E(): 1e-17%2C 29.8%25 identity in 292 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene8078 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.170 SCP1.171 SCP1.171 SCP1.171 166691 167584 + integral membrane protein possible integral membrane protein%2C len: 297aa%3B similar to TR:Q9L0R6 (EMBL:AL160312) integral membrane protein from Streptomyces coelicolor (302 aa) fasta scores%3B opt: 379%2C z-score: 425.8%2C E(): 3e-16%2C 30.3%25 identity in 297 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene8079 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.171 SCP1.172 SCP1.172 SCP1.172 167601 167792 + integral membrane protein possible integral membrane protein%2C len: 63aa%3B weak similarity to TR:Q9L0R5 (EMBL:AL160312) integral membrane protein from Streptomyces coelicolor (117 aa) fasta scores%3B opt: 78%2C z-score: 131.4%2C E(): 7.5%2C 40.7%25 identity in 27 aa overlap. Contains possible membrane-spanning hydrophobic regions. gene gene8080 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.172 SCP1.173 SCP1.173 SCP1.173 167825 168244 + hypothetical protein possible membrane protein%2C len: 139aa%3B contains a possible membrane-spanning hydrophobic region. gene gene8081 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.173 SCP1.174 SCP1.174 SCP1.174 168241 168684 + hypothetical protein possible membrane protein%2C len: 147aa%3B similar to TR:Q9KY94 (EMBL:AL356813) septum site-determining protein from Streptomyces coelicolor (131 aa) fasta scores%3B opt: 129%2C z-score: 161.9%2C E(): 0.15%2C 33.3%25 identity in 141 aa overlap. Contains a possible membrane-spanning hydrophobic region. gene gene8082 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.174 SCP1.175 SCP1.175 SCP1.175 168681 169124 + hypothetical protein possible membrane protein%2C len: 147aa%3B contains a possible membrane-spanning hydrophobic region. gene gene8083 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.175 SCP1.176 SCP1.176 SCP1.176 169131 172742 + large membrane protein possible large membrane protein%2C len: 1203aa%3B N-terminal region contains three possible membrane-spanning hydrophobic regions. Remainder similar to TR:Q9XAP0 (EMBL:AL078618) hypothetical protein from Streptomyces coelicolor (726 aa) fasta scores%3B opt: 457%2C z-score: 394.3%2C E(): 1.7e-14%2C 26.8%25 identity in 898 aa overlap. gene gene8084 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.176 SCP1.177 SCP1.177 SCP1.177 173067 173675 + hypothetical protein possible membrane protein%2C len: 202aa%3B contains three possible membrane-spanning hydrophobic regions. This gene lies in a region of unusually low GC content. gene gene8085 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.177 SCP1.178 SCP1.178 SCP1.178 173797 174033 + hypothetical protein unknown%2C len: 78aa gene gene8086 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.178 SCP1.179 SCP1.179 SCP1.179 174030 174191 + hypothetical protein unknown%2C len: 53aa gene gene8087 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.179 SCP1.180 SCP1.180 SCP1.180 174205 174516 + hypothetical protein unknown%2C len: 103aa gene gene8088 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.180 SCP1.181c SCP1.181c SCP1.181c 174623 175622 - gene gene8089 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.181c SCP1.182 SCP1.182 SCP1.182 175779 176534 + hypothetical protein unknown%2C len: 251aa gene gene8090 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.182 SCP1.183 SCP1.183 SCP1.183 176599 177141 + hypothetical protein unknown%2C len: 180aa gene gene8091 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.183 SCP1.183c SCP1.183c SCP1.183c 177213 177917 - hypothetical protein unknown%2C len: 234aa%3B weakly similar to TR:O07246 (EMBL:Z96800) hypothetical protein from Mycobacterium tuberculosis (220 aa) fasta scores%3B opt: 129%2C z-score: 156.4%2C E(): 0.3%2C 29.2%25 identity in 161 aa overlap. gene gene8092 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.183c SCP1.184 SCP1.184 SCP1.184 178160 178438 + hypothetical protein conserved hypothetical protein%2C len: 92aa%3B strongly similar to SCJ30.10c (TR:Q9S1X9 EMBL:AL109973) hypothetical protein from the chromosome end(s) of Streptomyces coelicolor (92 aa) fasta scores%3B opt: 499%2C z-score: 682.6%2C E(): 1.5e-30%2C 81.5%25 identity in 92 aa overlap. Also similar to SCE6.04 (TR:Q9KZT4 EMBL:AL353832) hypothetical protein from Streptomyces coelicolor (75 aa) fasta scores%3B opt: 107%2C z-score: 161.9%2C E(): 0.15%2C 30.9%25 identity in 81 aa overlap. Contains a TTA encoded leucine at residue 3%2C possible target for bldA regulation. gene gene8093 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.184 SCP1.185 SCP1.185 SCP1.185 178395 178949 + hypothetical protein conserved hypothetical protein%2C len: 184aa%3B similar to other hypothetical proteins from Streptomyces coelicolor eg. SCE6.05 (TR:Q9KZT3 EMBL:AL353832) (159 aa) fasta scores%3B opt: 518%2C z-score: 663.1%2C E(): 1.8e-29%2C 48.8%25 identity in 164 aa overlap and SCJ30.09C (TR:Q9S1Y0 EMBL:AL109973) (96 aa) fasta scores%3B opt: 438%2C z-score: 566.0%2C E(): 4.6e-24%2C 83.3%25 identity in 78 aa overlap. gene gene8094 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.185 SCP1.186 SCP1.186 SCP1.186 178957 179805 + hypothetical protein conserved hypothetical protein%2C len: 282aa%3B similar to other hypothetical proteins from streptomycetes eg. SCE6.06 (TR:Q9KZT2 EMBL:AL353832) from Streptomyces coelicolor (281 aa) fasta scores%3B opt: 882%2C z-score: 1083.5%2C E(): 0%2C 47.9%25 identity in 280 aa overlap. Note possible alternative downstream translational start site. gene gene8095 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.186 SCP1.187 SCP1.187 SCP1.187 179960 180511 + hypothetical protein unknown%2C len: 183aa gene gene8096 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.187 SCP1.188c SCP1.188c SCP1.188c 180497 180781 - hypothetical protein unknown%2C len: 94aa gene gene8097 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.188c SCP1.189 SCP1.189 SCP1.189 181083 182222 + hypothetical protein unknown%2C len: 379aa gene gene8098 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.189 SCP1.18c SCP1.18c SCP1.18c 13943 16294 - DNA integrase/recombinase possible DNA integrase/recombinase%2C len: 783aa%3B C-terminal region weakly similar to many members of the 'phage' integrase family eg. SW:P06697 (TNPB_STAAU) transposase B (transposon Tn554) from Staphylococcus aureus (630 aa) fasta scores%3B opt: 205%2C z-score: 242.4%2C E(): 4.9e-06%2C 22.1%25 identity in 280 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. gene gene7927 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.18c SCP1.190c SCP1.190c SCP1.190c 182335 183168 - integrase/recombinase possible integrase/recombinase%2C len: 277aa%3B similar to many eg. SW:P20184 (YT23_STRFR) hypothetical 23.1 kDa protein in transposon Tn4556 from Streptomyces fradiae (205 aa) fasta scores%3B opt: 559%2C z-score: 616.8%2C E(): 6.9e-27%2C 78.4%25 identity in 111 aa overlap and TR:O30680 (EMBL:AF015088) plasmid multimer resolution protein from plasmid pFAJ2600 of Rhodococcus erythropolis (306 aa) fasta scores%3B opt: 276%2C z-score: 308.0%2C E(): 1.1e-09%2C 33.9%25 identity in 227 aa overlap. gene gene8099 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.190c SCP1.191 SCP1.191 SCP1.191 183470 183649 + hypothetical protein unknown%2C len: 59aa gene gene8100 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.191 SCP1.192 SCP1.192 SCP1.192 183646 184086 + hypothetical protein unknown%2C len: 146aa gene gene8101 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.192 SCP1.194 SCP1.194 SCP1.194 184494 185051 + hypothetical protein unknown%2C len: 185aa gene gene8102 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.194 SCP1.195c SCP1.195c SCP1.195c 185658 186707 - atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 349aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). Note - correct CDS location may be on opposite strand. gene gene8103 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.195c SCP1.196 SCP1.196 SCP1.196 186710 188230 + DNA primase/helicase possible DNA primase/helicase%2C len: 506aa%3B previously sequenced and annotated as TR:Q9L8S3 (EMBL:AF195093)%2C note discrepency: SCP1.196 translational start site is 239 bases upstream of that designated for TR:Q9L8S3. Similar to others eg. TR:Q9ZX10 (EMBL:AF068845) GP70 from Mycobacteriophage TM4 (867 aa) fasta scores%3B opt: 1104%2C z-score: 1313.5%2C E(): 0%2C 42.6%25 identity in 470 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8104 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.196 SCP1.197 SCP1.197 SCP1.197 188227 188628 + hypothetical protein unknown%2C len: 133aa%3B previously sequenced as TR:Q9RMI9 (EMBL:AF195093). gene gene8105 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.197 SCP1.198 SCP1.198 SCP1.198 188734 189642 + hypothetical protein unknown%2C len: 302aa%3B Note possible alternative downstream translational start sites. gene gene8106 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.198 SCP1.199c SCP1.199c SCP1.199c 189929 191446 - secreted esterase possible secreted esterase%2C len: 505aa%3B similar to TR:Q54345 (EMBL:Z50108) esterase precursor from Streptomyces lividans (509 aa) fasta scores%3B opt: 659%2C z-score: 693.3%2C E(): 3.8e-31%2C 34.4%25 identity in 509 aa overlap. Contains Pfam match to entry PF00089 trypsin%2C Trypsin and possible cleavable N-terminal signal sequence. gene gene8107 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.199c SCP1.19c SCP1.19c SCP1.19c 16386 17612 - DNA integrase/recombinase possible DNA integrase/recombinase%2C len: 408aa%3B C-terminal region weakly similar to many members of the 'phage' integrase family eg. SW:P21891 (XERD_ECOLI) integrase/recombinase XerD from Escherichia coli (298 aa) fasta scores%3B opt: 195%2C z-score: 217.2%2C E(): 0.00012%2C 28.1%25 identity in 217 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. Possible upstream and downstream alternative translational strat sites. gene gene7928 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.19c SCP1.200c SCP1.200c SCP1.200c 191837 192337 - secreted protein possible secreted protein%2C len: 166aa%3B similar to TR:O87846 (EMBL:AL031013) secreted protein from Streptomyces coelicolor (168 aa) fasta scores%3B opt: 313%2C z-score: 373.4 %2CE(): 2.5e-13%2C 40.3%25 identity in 154 aa overlap. Contains a possible cleavable N-terminal signal sequence. gene gene8108 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.200c SCP1.201 SCP1.201 SCP1.201 192944 196954 + hypothetical protein unknown%2C len: 1336aa%3B similar to TR:O87848 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (1147 aa) fasta scores%3B opt: 1652%2C z-score: 1478.4%2C E(): 0%2C 38.7%25 identity in 926 aa overlap. Note possible alternative upstream translational start site which would give a possible N-terminal signal sequence. Contains several possible coiled-coil regions. gene gene8109 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.201 SCP1.202 SCP1.202 SCP1.202 196963 197466 + hypothetical protein unknown%2C len: 167aa gene gene8110 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.202 SCP1.203c SCP1.203c SCP1.203c 198102 198614 - hypothetical protein unknown%2C len: 170aa gene gene8111 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.203c SCP1.204c SCP1.204c SCP1.204c 198693 200354 - hypothetical protein unknown%2C len: 553aa gene gene8112 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.204c SCP1.205c SCP1.205c SCP1.205c 200576 203101 - hypothetical protein unknown%2C len: 841aa%3B weak but full length similarity to TR:O87242 (EMBL:AE001272) hypothetical protein from plasmid pMRC01 of Lactococcus lactis blastp scores%3B Identities %3D 223/824 (27%25)%2C Positives %3D 406/824 (49%25). gene gene8113 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.205c SCP1.206c SCP1.206c SCP1.206c 203314 203841 - hypothetical protein unknown%2C len: 175aa gene gene8114 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.206c SCP1.207c SCP1.207c SCP1.207c 203838 206540 - hypothetical protein unknown%2C len: 900aa gene gene8115 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.207c SCP1.208 SCP1.208 SCP1.208 207016 208056 + hypothetical protein unknown%2C len: 346aa gene gene8116 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.208 SCP1.209c SCP1.209c SCP1.209c 208371 209366 - hypothetical protein unknown%2C len: 331aa gene gene8117 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.209c SCP1.20c SCP1.20c SCP1.20c 17618 18400 - hypothetical protein unknown%2C len: 260aa gene gene7929 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.20c SCP1.210c SCP1.210c SCP1.210c 209380 209709 - hypothetical protein possible membrane protein%2C len: 109aa%3B contains two possible membrane-spanning hydrophobic regions. gene gene8118 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.210c SCP1.211c SCP1.211c SCP1.211c 210103 210534 - hypothetical protein unknown%2C len: 143aa gene gene8119 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.211c SCP1.212 SCP1.212 SCP1.212 211100 212794 + bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase possible bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase%2C len: 564aa%3B C-terminal similar to many undecaprenyl pyrophosphate synthetases eg. SW:Q47675 (UPPS_ECOLI) undecaprenyl pyrophosphate synthetase (EC 2.5.1.31) from Escherichia coli (253 aa) blastp scores%3B Identities %3D 94/226 (41%25)%2C Positives %3D 132/226 (58%25). N-terminal similar to many phytoene synthases eg. SW:P54977 (CRTB_STRGR) phytoene synthase (EC 2.5.1.-) from Streptomyces griseus (342 aa) blastp scores%3B Identities %3D 82/298 (27%25)%2C Positives %3D 133/298 (44%25). C-terminal region contains Pfam match to entry PF01255 UPP_synthetase%2C undecaprenyl diphosphate synthase. Contains a TTA encoded leucine at residue 11%2C possible target for bldA regulation. gene gene8120 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.212 SCP1.213c SCP1.213c SCP1.213c 212818 213495 - secreted protein possible secreted protein%2C len: 225aa%3B contains a possible cleavable N-terminal signal sequence. gene gene8121 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.213c SCP1.214 SCP1.214 SCP1.214 213631 214053 + transposase possible transposase%2C len: 140aa%3B similar to many eg. TR:Q9XAE6 (EMBL:AL079356) transposase from Streptomyces coelicolor (136 aa) fasta scores%3B opt: 536%2C z-score: 679.6%2C E(): 2.2e-30%2C 60.8%25 identity in 143 aa overlap. Contains Pfam match to entry PF01511 Transposase_6%2C Transposase. Part of possible transposon comprising CDSs SCP1.14%2C SCP1.15 and SCP1.16. Translation may involve a frameshift into downstream CDS. gene gene8122 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.214 SCP1.215 SCP1.215 SCP1.215 214050 214520 + transposase possible transposase%2C len: 156aa%3B similar to many eg. TR:Q9XAE7 (EMBL:AL079356) transposase from Streptomyces coelicolor (148 aa) fasta scores%3B opt: 557%2C z-score: 682.8%2C E(): 1.5e-30%2C 58.0%25 identity in 150 aa overlap. Part of possible transposon comprising CDSs SCP1.14%2C SCP1.15 and SCP1.16. Translation may involve a frameshift into upstream CDS. gene gene8123 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.215 SCP1.216 SCP1.216 SCP1.216 214585 215106 + hypothetical protein unknown%2C len: 173aa%3B part of possible transposon comprising CDSs SCP1.14%2C SCP1.15 and SCP1.16. gene gene8124 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.216 SCP1.216Ac SCP1.216Ac SCP1.216Ac 215655 217487 - helicase possible helicase%2C len: 610aa%3B inverted and duplicated therefore similar to SCP1.136 (879 aa) fasta scores%3B .opt: 3788%2C z-score: 4060.4%2C E(): 0%2C 93.0%25 identity in 599 aa overlap. gene gene8125 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.216Ac SCP1.217 SCP1.217 SCP1.217 217465 217674 + hypothetical protein unknown%2C len: 69aa gene gene8126 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.217 SCP1.217Ac SCP1.217Ac SCP1.217Ac 217949 219094 - hypothetical protein unknown%2C len: 381aa%3B flanked by inverted repeat at 217861-217881 and 219205-219225 (Score 56: 20/21 ( 95%25) matches%2C 0 gaps). gene gene8127 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.217Ac SCP1.218c SCP1.218c SCP1.218c 219314 219700 - hypothetical protein unknown%2C len: 128aa gene gene8128 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.218c SCP1.219 SCP1.219 SCP1.219 219981 220502 + hypothetical protein unknown%2C len: 173aa%3B similar to others from Streptomyces coelicolor eg. TR:Q9Z552 (EMBL:AL035212) hypothetical protein (162 aa) blastp scores%3B Identities %3D 60/162 (37%25)%2C Positives %3D 80/162 (49%25) and SW:P14706 (YM2_STRCO) mini-circle hypothetical 13.3 kDa protein (122 aa) blastp scores%3B Identities %3D 38/118 (32%25)%2C Positives %3D 60/118 (50%25). gene gene8129 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.219 SCP1.21c SCP1.21c SCP1.21c 18421 19278 - hypothetical protein unknown%2C len: 285aa gene gene7930 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.21c SCP1.221 SCP1.221 parA2 parA2 221485 222648 + plasmid partitioning protein%2C para2 parA2%2C possible plasmid partitioning protein%2C len: 387aa%3B weakly similar to many eg. SW:P08866 (SOPA_ECOLI) sopA protein essential for F plasmid partitioning in Escherichia coli (388 aa) fasta scores%3B opt: 195%2C z-score: 215.5%2C E(): 2.9e-05%2C 27.7%25 identity in 213 aa overlap. Contains Pfam match to entry PF00991 ParA%2C ParA family ATPase. This CDS is directly duplicated at 221485..222648 (ParA1%2C SCP1.138) fasta scores%3B opt: 980%2C z-score: 954.5%2C E(): 0%2C 55.4%25 identity in 424 aa overlap. gene gene8130 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.221 SCP1.222 SCP1.222 parB2 parB2 222645 223790 + plasmid partitioning protein%2C parb2 parB2%2C possible plasmid partitioning protein%2C len: 381aa%3B weakly similar to many eg. SW:P26497 (SP0J_BACSU) Spo0J protein required for initiation of sporulation and normal chromosome segregation in Bacillus subtilis (282 aa) fasta scores%3B opt: 213%2C z-score: 210.9%2C E(): 5.3e-05%2C 30.2%25 identity in 212 aa overlap. Contains Pfam match to entry PF02195 ParBc%2C ParB-like nuclease domain. This CDS is directly duplicated at 130087..131214 (ParB1%2C SCP1.139) fasta scores%3B opt: 566%2C z-score: 538.4%2C E(): 1.8e-25%2C 33.6%25 identity in 384 aa overlap. gene gene8131 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.222 SCP1.223c SCP1.223c SCP1.223c 224000 224353 - hypothetical protein unknown%2C len: 117aa gene gene8132 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.223c SCP1.224c SCP1.224c dnaE dnaE 224350 227991 - DNA polymerase III subunit alpha catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time%3B main replicative polymerase gene gene8133 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.224c SCP1.225 SCP1.225 23.ORF4 23.ORF4 228782 229135 + hypothetical protein unknown%2C len: 117aa%3B previously partially sequenced and annotated as TR:Q9JN71 (EMBL:AJ276673). Note possible alternative downstream translational start sites. gene gene8134 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.225 SCP1.226 SCP1.226 23.ORF3 23.ORF3 229131 229518 + hypothetical protein unknown%2C len: 128aa%3B previously sequenced and annotated as TR:Q9JN72 (EMBL:AJ276673). Similar to TR:Q9KXJ3 (EMBL:AL357591) hypothetical protein from Streptomyces coelicolor (128 aa) fasta scores%3B opt: 406%2C z-score: 539.2%2C E(): 1.5e-22%2C 52.3%25 identity in 128 aa overlap. gene gene8135 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.226 SCP1.227 SCP1.227 23.ORF2 23.ORF2 229671 230153 + hypothetical protein unknown%2C len: 160aa%3B previously sequenced and annotated as TR:Q9JN73 (EMBL:AJ276673). gene gene8136 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.227 SCP1.227c SCP1.227c 23.ORF1 23.ORF1 230263 230964 - hypothetical protein unknown%2C len: 233aa%3B previously sequenced and annotated as TR:Q9JN74 (EMBL:AJ276673). Similar to TR:Q9KZ23 (EMBL:AL355752) reductase from Streptomyces coelicolor (366 aa) fasta scores%3B opt: 496%2C z-score: 569.0%2C E(): 3.2e-24%2C 38.2%25 identity in 212 aa overlap. gene gene8137 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.227c SCP1.228c SCP1.228c mmyF mmyF 231676 232200 - oxidoreductase%2C mmyf mmyF%2C possible oxidoreductase%2C len: 174aa%3B previously sequenced and annotated as TR:Q9JN75 (EMBL:AJ276673). Similar to many oxidoreductases eg. N-terminal region of SW:P54990 (NTAB_CHEHE) nitrilotriacetate monooxygenase component B (EC 1.14.13.-) from Chelatobacter heintzii (322 aa) fasta scores%3B opt: 419%2C z-score: 522.1%2C E(): 1.3e-21%2C 41.4%25 identity in 169 aa overlap and SW:Q02058 (DIM6_STRCO) actinorhodin polyketide dimerase from Streptomyces coelicolor (177 aa) fasta scores%3B opt: 295%2C z-score: 373.9%2C E(): 2.3e-13%2C 31.0%25 identity in 158 aa overlap. Contains Pfam match to entry PF01613 Flavin_Reduct%2C Flavin reductase like domain. gene gene8138 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.228c SCP1.229c SCP1.229c mmyY mmyY 232231 232692 - hypothetical protein mmyY%2C hypothetical protein%2C len: 153aa%3B previously partially sequenced and annotated as TR:Q9JN76 (EMBL:AJ276673). gene gene8139 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.229c SCP1.22c SCP1.22c SCP1.22c 19353 19586 - hypothetical protein unknown%2C len: 77aa gene gene7931 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.22c SCP1.230 SCP1.230 mmyB mmyB 232923 233864 + DNA-binding protein%2C mmyb mmyB%2C possible DNA-binding protein%2C len: 313aa%3B previously sequenced and annotated as TR:Q9JN77 (EMBL:AJ276673). Similar to many from Streptomyces coelicolor eg. TR:Q9RDF4 (EMBL:AL136503) DNA-binding protein (294 aa) fasta scores%3B opt: 670%2C z-score: 810.9%2C E(): 0%2C 43.1%25 identity in 255 aa overlap. Contains helix-turn-helix motif at residue 52-73 (Score 1329 (+3.71 SD)). Contains a TTA encoded leucine at residue 23%2C possible target for bldA regulation. gene gene8140 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.230 SCP1.231 SCP1.231 mmyQ mmyQ 233951 234604 + hypothetical protein mmyQ%2C hypothetical protein%2C len: 217aa%3B previously sequenced and annotated as TR:Q9JN78 (EMBL:AJ276673). Similar to TR:Q9L1E0 (EMBL:AL157916) hypothetical protein from Streptomyces coelicolor (220 aa) fasta scores%3B opt: 314%2C z-score: 377.8%2C E(): 1.4e-13%2C 35.2%25 identity in 199 aa overlap. gene gene8141 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.231 SCP1.232 SCP1.232 mmyE mmyE 234674 235837 + enoyl reductase%2C mmye mmyE%2C possible enoyl reductase%2C len: 387aa%3B previously sequenced and annotated as TR:Q9JN79 (EMBL:AJ276673). Similar to SW:P77258 (NEMA_ECOLI) N-ethylmaleimide reductase (EC 1.-.-.-) from Escherichia coli (365 aa) fasta scores%3B opt: 507%2C z-score: 566.6%2C E(): 4.3e-24%2C 31.6%25 identity in 380 aa overlap. Contains Pfam match to entry PF00724 oxidored_FMN%2C NADH:flavin oxidoreductase / NADH oxidase family. gene gene8142 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.232 SCP1.233 SCP1.233 mmyD mmyD 236410 237429 + hypothetical protein mmyD%2C hypothetical protein%2C len: 339aa%3B previously sequenced and annotated as TR:Q9JN80 (EMBL:AJ276673). Similar to TR:Q52426 (EMBL:L11334) AvrD%2C avirulence protein from Pseudomonas syringae (311 aa) fasta scores%3B opt: 253%2C z-score: 309.5%2C E(): 9e-10%2C 31.4%25 identity in 334 aa overlap. gene gene8143 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.233 SCP1.233A SCP1.233A mmyX mmyX 237541 238245 + atp/GTP-binding protein%2C mmyx mmyX%2C possible ATP/GTP-binding protein%2C len: 234aa%3B previously sequenced and annotated as TR:Q9JN81 (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.236 MmyK%2C ATP/GTP-binding protein (206 aa)(previously sequenced as TR:Q9JN85 (EMBL:AJ276673) hypothetical protein) fasta scores%3B opt: 538%2C z-score: 647.7%2C E(): 1.3e-28%2C 42.7%25 identity in 199 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8144 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.233A SCP1.233B SCP1.233B mmyC mmyC 238242 239240 + 3-oxoacyl-ACP synthase III FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs gene gene8145 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.233B SCP1.234 SCP1.234 mmyA mmyA 239304 239552 + acyl carrier protein%2C mmya mmyA%2C possible acyl carrier protein%2C len: 82aa%3B previously sequenced and annotated as hypothetical protein TR:Q9JN83 (EMBL:AJ276673). Similar to many acyl carrier proteins eg. TR:Q54497 (EMBL:AJ224512) acyl carrier protein from Streptomyces nogalater (86 aa) fasta scores%3B opt: 146%2C z-score: 218.3%2C E(): 0.00011%2C 41.0%25 identity in 78 aa overlap. Contains Pfam match to entry PF00550 pp-binding%2C Phosphopantetheine attachment site. gene gene8146 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.234 SCP1.235 SCP1.235 mmyP mmyP 239676 240374 + hypothetical protein mmyP%2C hypothetical protein%2C len: 232aa%3B previously sequenced and annotated as TR:Q9JN84 (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.245 mmfP (previously sequenced as TR:Q9JN92 (EMBL:AJ276673)) fasta scores%3B opt: 453%2C z-score: 556.3%2C E(): 1.6e-23%2C 38.9%25 identity in 234 aa overlap. gene gene8147 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.235 SCP1.236 SCP1.236 mmyK mmyK 240371 240991 + atp/GTP-binding protein%2C mmyk mmyK%2C possible ATP/GTP-binding protein%2C len: 206aa%3B previously sequenced and annotated as TR:Q9JN85 (EMBL:AJ276673). Also similar to neighbouring CDS SCP1.233A MmyX%2C ATP/GTP-binding protein (234 aa) (previously sequenced as TR:Q9JN81 (EMBL:AJ276673) hypothetical protein) fasta scores%3B opt: 538%2C z-score: 647.7%2C E(): 1.3e-28%2C 42.7%25 identity in 199 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8148 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.236 SCP1.237c SCP1.237c mmr mmr 241054 242481 - methylenomycin a resistance protein%2C mmr mmr%2C methylenomycin A resistance protein%2C len: 475aa%3B previously sequenced and annotated as hypothetical protein SW:P11545 (MMR_STRCO) (EMBL:AJ276673). Similar to many others eg. SW:P39886 (TCMA_STRGA) tetracenomycin C resistance and export protein from Streptomyces glaucescens (538 aa) fasta scores%3B opt: 797%2C z-score: 882.3%2C E(): 0%2C 32.7%25 identity in 425 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene8149 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.237c SCP1.238 SCP1.238 mmyJ mmyJ 242698 243033 + hypothetical protein mmyJ%2C hypothetical protein%2C len: 111aa%3B previously sequenced and annotated as TR:Q52517 (EMBL:AJ276673). Similar to many others eg. TR:O31480 (EMBL:Z99106) hypothetical protein from Bacillus subtilis (104 aa) fasta scores%3B opt: 279%2C z-score: 375.5%2C E(): 1.9e-13%2C 45.4%25 identity in 97 aa overlap. gene gene8150 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.238 SCP1.239c SCP1.239c mmyG mmyG 242996 244177 - oxidoreductase%2C mmyg mmyG%2C possible oxidoreductase%2C len: 393aa%3B previously sequenced and annotated as TR:Q9JN86 (EMBL:AJ276673). Similar to many eg. TR:Q9RK99 (EMBL:AL117322) oxidoreductase from Streptomyces coelicolor (371 aa) fasta scores%3B opt: 675%2C z-score: 754.9%2C E(): 0%2C 36.4%25 identity in 357 aa overlap. Contains Pfam match to entry PF01408 GFO_IDH_MocA%2C Oxidoreductase family. gene gene8151 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.239c SCP1.23c SCP1.23c SCP1.23c 19574 19708 - hypothetical protein unknown%2C doubtful CDS%2C len: 44aa gene gene7932 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.23c SCP1.24 SCP1.24 SCP1.24 19920 20165 + hypothetical protein unknown%2C doubtful CDS%2C len: 81aa gene gene7933 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.24 SCP1.240c SCP1.240c mmyO mmyO 244260 245381 - monooxygenase%2C mmyo mmyO%2C possible monooxygenase%2C len: 373aa%3B previously sequenced and annotated as alkanal monooxygenase TR:Q9JN87 (EMBL:AJ276673). Similar to weakly similar to SW:P07740 (LUXA_VIBHA) alkanal monooxygenase alpha chain (EC 1.14.14.3) from Vibrio harveyi (355 aa) fasta scores%3B opt: 215%2C z-score: 254.6%2C E(): 1e-06%2C 22.1%25 identity in 272 aa overlap. Contains Pfam match to entry PF00296 bac_luciferase%2C Bacterial luciferase. gene gene8152 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.240c SCP1.241c SCP1.241c mmyT mmyT 245412 246221 - thioesterase%2C mmyt mmyT%2C possible thioesterase%2C len: 269aa%3B previously sequenced and annotated as TR:Q9JN88 (EMBL:AJ276673) - note difference in predicted translational start site. Similar to many others eg. SW:P14686 (GRST_BACBR) gramicidin S biosynthesis GrsT protein (EC 3.1.2.-) from Bacillus brevis (256 aa) fasta scores%3B opt: 289%2C z-score: 338.3%2C E(): 2.2e-11%2C 29.7%25 identity in 256 aa overlap. Contains Pfam match to entry PF00975 Thioesterase%2C Thioesterase domain gene gene8153 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.241c SCP1.242c SCP1.242c mmfR mmfR 246362 247006 - TetR family transcriptional regulator mmfR%2C possible lactone-dependent transcriptional regulator (TetR-family)%2C len: 214aa%3B previously sequenced and annotated as hypothetical protein TR:Q9JN89 (EMBL:AJ276673). Similar to many lactone-dependent transcriptional regulators eg. TR:Q54189 (EMBL:D49782) A-factor receptor from Streptomyces griseus (276 aa) fasta scores%3B opt: 342%2C z-score: 422.0%2C E(): 4.9e-16%2C 33.0%25 identity in 182 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif at residue 50-71 (Score 1532 (+4.40 SD)). gene gene8154 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.242c SCP1.243 SCP1.243 mmfL mmfL 247201 248262 + lactone biosynthesis protein%2C mmfl mmfL%2C possible lactone biosynthesis protein%2C len: 353aa%3B previously sequenced and annotated as hypothetical protein TR:Q9JN90 (EMBL:AJ276673). Similar to many others eg. TR:O86851 (EMBL:AJ007731) ScbA gamma-butyrolactone biosynthesis protein from Streptomyces coelicolor (314 aa) fasta scores%3B opt: 336%2C z-score: 389.2%2C E(): 3.3e-14%2C 28.7%25 identity in 310 aa overlap. Contains a TTA encoded leucine at residue 8%2C possible target for bldA regulation. gene gene8155 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.243 SCP1.244 SCP1.244 mmfH mmfH 248259 249461 + oxidoreductase%2C mmfh mmfH%2C possible oxidoreductase%2C len: 400aa%3B previously sequenced and annotated as hypothetical protein TR:Q9JN91 (EMBL:AJ276673). similar to many possible oxidoreductases eg. TR:O68921 (EMBL:AF058302) enoyl reductase%2C FrnT from polyketide antibiotic frenolicin biosynthetic cluster of Streptomyces roseofulvus (396 aa) fasta scores%3B opt: 867%2C z-score: 921.4%2C E(): 0%2C 48.0%25 identity in 329 aa overlap. gene gene8156 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.244 SCP1.245 SCP1.245 mmfP mmfP 249458 250255 + hypothetical protein mmfP%2C hypothetical protein%2C len: 265aa%3B previously sequenced and annotated as TR:Q9JN92 (EMBL:AJ276673). Similar to SW:O33611 (IMD_STRCN) inhibition of morphological differentiation protein from Streptomyces cyaneus (Streptomyces curacoi) (277 aa) fasta scores%3B opt: 329%2C z-score: 384.0%2C E(): 6.4e-14%2C 32.0%25 identity in 225 aa overlap. Also similar to neighbouring CDS SCP1.235 mmyP (previously sequenced as TR:Q9JN84 (EMBL:AJ276673)) fasta scores%3B opt: 453%2C z-score: 556.3%2C E(): 1.6e-23%2C 38.9%25 identity in 234 aa overlap. gene gene8157 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.245 SCP1.246 SCP1.246 mmyR mmyR 250406 251017 + TetR family transcriptional regulator mmyR%2C possible lactone-dependent transcriptional regulator (TetR-family)%2C len: 203aa%3B previously sequenced and annotated as hypothetical protein TR:Q9JN93 (EMBL:AJ276673). Weakly similar to many lactone-dependent transcriptional regulators eg. CprS protein from Streptomyces coelicolor (215 aa) fasta scores%3B opt: 240%2C z-score: 299.2%2C E(): 3.3e-09%2C 26.9%25 identity in 193 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family and helix-turn-helix motif at residue 29-50 (Score 1129 (+3.03 SD)). gene gene8158 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.246 SCP1.247c SCP1.247c SCP1.247c 251127 251561 - hypothetical protein unknown%2C len: 144aa%3B similar to TR:Q9RJS4 (EMBL:AL132707) hypothetical protein from Streptomyces coelicolor (127 aa) fasta scores%3B opt: 229%2C z-score: 300.2%2C E(): 3e-09%2C 37.3%25 identity in 110 aa overlap. gene gene8159 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.247c SCP1.248c SCP1.248c SCP1.248c 251565 251804 - hypothetical protein unknown%2C len: 79aa gene gene8160 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.248c SCP1.249c SCP1.249c SCP1.249c 251995 252324 - hypothetical protein possible membrane protein%2C len: 109aa%3B contains possible membrane-spanning hydrophobic region. gene gene8161 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.249c SCP1.250 SCP1.250 SCP1.250 252528 252950 + hypothetical protein unknown%2C len: 140aa gene gene8162 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.250 SCP1.251 SCP1.251 SCP1.251 253207 253575 + hypothetical protein unknown%2C len: 122aa gene gene8163 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.251 SCP1.252c SCP1.252c SCP1.252c 253719 254249 - hypothetical protein unknown%2C len: 122176aa gene gene8164 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.252c SCP1.253 SCP1.253 SCP1.253 254385 255002 + hypothetical protein unknown%2C len: 205aa gene gene8165 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.253 SCP1.254c SCP1.254c SCP1.254c 255286 255909 - hypothetical protein unknown%2C len: 207aa gene gene8166 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.254c SCP1.255c SCP1.255c SCP1.255c 255857 256288 - hypothetical protein unknown%2C len: 205aa gene gene8167 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.255c SCP1.256c SCP1.256c SCP1.256c 256449 256613 - hypothetical protein doubtful CDS%2C unknown%2C len: 54aa gene gene8168 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.256c SCP1.257 SCP1.257 SCP1.257 256995 257408 + hypothetical protein unknown%2C hydrophilic%2C len: 137aa gene gene8169 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.257 SCP1.258c SCP1.258c SCP1.258c 257545 258045 - hypothetical protein unknown%2C alanine-rich%2C len: 166aa gene gene8170 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.258c SCP1.259 SCP1.259 SCP1.259 258163 259413 + transposon transposase probable transposon transposase%2C len: 416aa%3B similar to many eg. SW:P35883 (TRA0_MYCSM) transposase for insertion sequence element IS6120 from Mycobacterium smegmatis (323 aa) fasta scores%3B opt: 1474%2C z-score: 1699.7%2C E(): 0%2C 72.7%25 identity in 300 aa overlap and SW:Q52873 (TRA5_RHIME) transposase for insertion sequence element ISRM5 from Rhizobium meliloti (Sinorhizobium meliloti) (398 aa) fasta scores%3B opt: 411%2C z-score: 476.6%2C E(): 8.4e-20%2C 26.3%25 identity in 373 aa overlap. Contains Pfam match to entry PF00872 Transpo_mutator%2C Transposase%2C Mutator family and Prosite match to PS01007 Transposases%2C Mutator family%2C signature. gene gene8171 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.259 SCP1.25c SCP1.25c SCP1.25c 20274 21338 - hypothetical protein unknown%2C len: 354aa gene gene7934 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.25c SCP1.260 SCP1.260 SCP1.260 259437 259787 + hypothetical protein unknown%2C len: 116aa%3B lies within a possible transposon gene gene8172 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.260 SCP1.261c SCP1.261c SCP1.261c 260052 260555 - secreted protein possible secreted protein%2C len: 167aa%3B N-terminus strongly similar to that from TR:Q9S1W2 (EMBL:AL109950) hypothetical protein SCJ4.11 from Streptomyces coelicolor. Contains a possible cleavable N-terminal signal sequence. gene gene8173 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.261c SCP1.262 SCP1.262 SCP1.262 260796 261038 + hypothetical protein unknown%2C len: 80aa gene gene8174 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.262 SCP1.263c SCP1.263c SCP1.263c 261236 261547 - hypothetical protein possible membrane protein%2C len: 103aa%3B contains possible membrane-spanning hydrophobic region. gene gene8175 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.263c SCP1.264 SCP1.264 SCP1.264 261683 263065 + hypothetical protein unknown%2C len: 460aa gene gene8176 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.264 SCP1.265c SCP1.265c SCP1.265c 263311 264000 - hypothetical protein unknown%2C len: 229aa gene gene8177 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.265c SCP1.266c SCP1.266c SCP1.266c 264034 264486 - hypothetical protein unknown%2C len: 150aa gene gene8178 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.266c SCP1.267 SCP1.267 SCP1.267 264803 265462 + secreted protein possible secreted protein%2C len: 219aa%3B similar to TR:Q9KY42 (EMBL:AL356892) hypothetical protein from Streptomyces coelicolor fasta scores%3B opt: 496%2C z-score: 616.3%2C E(): 8.7e-27%2C 44.7%25 identity in 197 aa overlap. Strongly similar to others on the same plasmid eg. SCP1.323c fasta scores%3B opt: 1190%2C z-score: 1292.7%2C E(): 0%2C 77.5%25 identity in 218 aa overlap%2C SCP1.31 fasta scores%3B opt: 1190%2C z-score: 1292.7%2C E(): 0%2C 77.5%25 identity in 218 aa overlap and C-terminus similar to immediately downstream CDS SCP1.268 fasta scores%3B opt: 468%2C z-score: 519.5%2C E(): 2e-24%2C 74.5%25 identity in 98 aa overlap. Contains a possible cleavable N-terminal signal sequence gene gene8179 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.267 SCP1.268 SCP1.268 SCP1.268 265459 265794 + hypothetical protein unknown%2C len: 111aa%3B strongly similar to the C-termini of others on the same plasmid eg. the immediately upstream CDS SCP1.267 (fasta scores%3B opt: 468%2C z-score: 578.4%2C E(): 1.1e-27%2C 74.5%25 identity in 98 aa overlap)%2C SCP1.36 (fasta scores%3B opt: 401%2C z-score: 496.6%2C E(): 3.9e-23%2C 57.4%25 identity in 108 aa overlap) and SCP1.490c (fasta scores%3B opt: 401%2C z-score: 496.6%2C E(): 3.9e-23%2C 57.4%25 identity in 108 aa overlap). gene gene8180 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.268 SCP1.269 SCP1.269 SCP1.269 265831 266202 + secreted protein possible secreted protein%2C len: 123aa%3B contains a possible cleavable N-terminal signal sequence. gene gene8181 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.269 SCP1.26c SCP1.26c SCP1.26c 22062 22904 - hypothetical protein unknown%2C len: 280aa gene gene7935 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.26c SCP1.270 SCP1.270 SCP1.270 266354 266644 + hypothetical protein unknown%2C doubtful CDS%2C len: 96aa gene gene8182 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.270 SCP1.271 SCP1.271 SCP1.271 266719 266880 + hypothetical protein unknown%2C doubtful CDS%2C len: 53aa gene gene8183 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.271 SCP1.272c SCP1.272c SCP1.272c 266896 267342 - hypothetical protein unknown%2C doubtful CDS%2C len: 148aa gene gene8184 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.272c SCP1.273c SCP1.273c SCP1.273c 267556 270675 - large secreted protein possible large secreted protein%2C len: 1039aa%3B similar to others eg. TR:Q9RKV7 (EMBL:AL132997) serine/threonine protein kinase SC9G1.09 from Streptomyces coelicolor fasta scores: E(): 0%2C 32.4%25 id in 675 aa%2C and to SW:WAPA_BACSU (Q07833) wall-associated protein precursor WapA from Bacillus subtilis fasta scores: E(): 0.00021%2C 21.9%25 id in 1078 aa. Contains a possible cleavable N-terminal signal sequence. gene gene8185 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.273c SCP1.274 SCP1.274 SCP1.274 271060 277308 + large secreted protein possible large secreted protein%2C len: 2082aa%3B similar to TR:O86585 (EMBL:AL031514) hypothetical protein SC2H4.02 from Streptomyces coelicolor (2183 aa) fasta scores: E(): 0%2C 38.4%25 id in 1958 aa. Contains a possible cleavable N-terminal signal sequence. gene gene8186 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.274 SCP1.275 SCP1.275 SCP1.275 277758 278123 + hypothetical protein unknown%2C doubtful CDS%2C len: 121aa gene gene8187 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.275 SCP1.276 SCP1.276 SCP1.276 279323 280864 + insertion element is466s transposase Insertion element IS466S transposase%2C len: 513aa%3B found in both the Streptomyces coelicolor chromosome and SCP1 plasmid. Previously sequenced and annotated as TR:Q9R2U5 (EMBL:AL133236) IS466A OR IS466A-ORF OR tnpA OR IS469. Contains Pfam match to entry PF01610 Transposase_12%2C Transposase. Contains a TTA encoded leucine at residue 122%2C possible target for bldA regulation. gene gene8188 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.276 SCP1.277 SCP1.277 SCP1.277 280963 281178 + hypothetical protein unknown%2C doubtful CDS%2C len: 71aa gene gene8189 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.277 SCP1.278 SCP1.278 SCP1.278 281951 282247 + hypothetical protein unknown%2C len: 361aa gene gene8190 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.278 SCP1.279c SCP1.279c SCP1.279c 282655 283740 - hypothetical protein unknown%2C len: 361aa gene gene8191 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.279c SCP1.27c SCP1.27c SCP1.27c 23099 26470 - hypothetical protein unknown%2C len: 1123aa gene gene7936 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.27c SCP1.280 SCP1.280 SCP1.280 283966 285579 + hypothetical protein unknown%2C len: 537aa%3B weakly similar to TR:Q9L0Y7 (EMBL:AL159139) hypothetical protein from Streptomyces coelicolor (475 aa) fasta scores%3B opt: 141%2C z-score: 161.2%2C E(): 0.16%2C 26.0%25 identity in 407 aa overlap. gene gene8192 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.280 SCP1.281 SCP1.281 SCP1.281 285645 286310 + hypothetical protein unknown%2C len: 115aa gene gene8193 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.281 SCP1.282 SCP1.282 SCP1.282 286320 286571 + hypothetical protein unknown%2C len: 83aa gene gene8194 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.282 SCP1.283 SCP1.283 SCP1.283 286639 286803 + hypothetical protein doubtful CDS%2C unknown%2C len: 54aa gene gene8195 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.283 SCP1.284 SCP1.284 SCP1.284 287152 287499 + hypothetical protein unknown%2C len: 115aa gene gene8196 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.284 SCP1.285c SCP1.285c SCP1.285c 287572 288471 - hypothetical protein possible conserved secreted protein%2C len: 299aa%3B similar to many eg. TR:Q9XAF8 (EMBL:AL079356) hypothetical protein from Streptomyces coelicolor (365 aa) fasta scores%3B opt: 999%2C z-score: 1101.9%2C E(): 0%2C 52.8%25 identity in 303 aa overlap. Contains a possible cleavable N-terminal signal sequence gene gene8197 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.285c SCP1.286 SCP1.286 SCP1.286 288811 289065 + hypothetical protein unknown%2C len: 84aa%3B similar to SCP1.225 hypothetical protein (previously sequenced as TR:Q9JN71 (EMBL:AJ276673)) from this plasmid fasta scores: E(): 1.1%2C 40.7%25 id in 81 aa. gene gene8198 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.286 SCP1.287 SCP1.287 SCP1.287 289068 289436 + hypothetical protein unknown%2C len: 122aa%3B weakly similar to TR:Q9KXJ3 (EMBL:AL357591) hypothetical protein from Streptomyces coelicolor (128 aa) fasta scores%3B opt: 102%2C z-score: 146.2%2C E(): 1.1%2C 26.7%25 identity in 120 aa overlap. gene gene8199 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.287 SCP1.288c SCP1.288c SCP1.288c 289447 292125 - atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 892aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8200 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.288c SCP1.289 SCP1.289 SCP1.289 292322 292597 + hypothetical protein unknown%2C len: 91aa gene gene8201 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.289 SCP1.28c SCP1.28c SCP1.28c 26523 26876 - hypothetical protein unknown%2C len: 117aa gene gene7937 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.28c SCP1.29 SCP1.29 SCP1.29 27692 28150 + hypothetical protein unknown%2C len: 152aa gene gene7938 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.29 SCP1.290c SCP1.290c SCP1.290c 292561 294369 - atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 602aa%3B weakly similar to others from plasmids eg. TR:Q9XAX4 (EMBL:U88088) hypothetical protein from plasmid pRA2 of Pseudomonas alcaligenes (522 aa) fasta scores%3B opt: 263%2C z-score: 287.6%2C E(): 1.5e-08%2C 22.9%25 identity in 498 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene8202 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.290c SCP1.291c SCP1.291c SCP1.291c 294467 294880 - hypothetical protein unknown%2C len: 137aa gene gene8203 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.291c SCP1.292c SCP1.292c SCP1.292c 295281 295505 - regulatory protein possible regulatory protein%2C len: 74aa%3B similar to many eg. TR:Q53896 (EMBL:X60316) AbaA pleiotropic regulatory protein from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 149%2C z-score: 226.2%2C E(): 3.9e-05%2C 40.4%25 identity in 57 aa overlap and TR:Q9RHR6 (EMBL:AB025200) ORF76 protein from plasmid pNO33 of Streptomyces albulus (76 aa) fasta scores%3B opt: 309%2C z-score: 448.7%2C E(): 1.6e-17%2C 60.3%25 identity in 73 aa overlap. gene gene8204 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.292c SCP1.293c SCP1.293c SCP1.293c 295502 296374 - DNA-binding protein possible conserved DNA-binding protein%2C len: 290aa%3B similar to many from streptomycetes eg. TR:Q9RHR7 (EMBL:AB025200) ORF312 protein from plasmid pNO33 of Streptomyces albulus (285 aa) fasta scores%3B opt: 857%2C z-score: 1027.5%2C E(): 0%2C and TR:CAB88448 (EMBL:AL353815) DNA-binding protein from Streptomyces coelicolor (295 aa) fasta scores%3B opt: 706%2C z-score: 847.4%2C E(): 0%2C 40.8%25 identity in 282 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. gene gene8205 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.293c SCP1.294 SCP1.294 SCP1.294 296628 297104 + hypothetical protein unknown%2C len: 145aa%3B similar to regions of others of undefined function eg. TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores%3B opt: 272%2C z-score: 347.5%2C E(): 6.9e-12%2C 39.4%25 identity in 127 aa overlap. gene gene8206 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.294 SCP1.295 SCP1.295 SCP1.295 297122 297565 + regulatory protein possible regulatory protein%2C len: 147aa%3B similar to others from Streptomyces coelicolor eg. TR:Q53897 (EMBL:X60316) AbaA pleiotropic regulatory protein from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 112%2C z-score: 149.1%2C E(): 0.77%2C 31.7%25 identity in 120 aa overlap. Contains TTA encoded leucine at residue 11%2C possible target for bldA regulation. gene gene8207 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.295 SCP1.296 SCP1.296 SCP1.296 297562 298101 + hypothetical protein unknown%2C len: 179aa gene gene8208 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.296 SCP1.297 SCP1.297 sapC sapC 298131 298583 + spore associated protein%2C sapc spore associated protein%2C SapC%2C len: 150aa%3B similar to TR:Q9KYK7 (EMBL:AL356593) secreted protein from Streptomyces coelicolor (155 aa) fasta scores%3B opt: 346%2C z-score: 450.7%2C E(): 1.2e-17%2C 40.5%25 identity in 131 aa overlap. Contains a possible cleavable N-terminal signal sequence. gene gene8209 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.297 SCP1.299 SCP1.299 SCP1.299 298580 299404 + hydratase probable hydratase%2C len: 274aa%3B similar to many eg. SW:P77608 (MHPD_ECOLI) 2-keto-4-pentenoate hydratase (EC 4.2.1.-) from Escherichia coli (269 aa) fasta scores%3B opt: 420%2C z-score: 525.4%2C E(): 8.5e-22%2C 34.3%25 identity in 245 aa overlap. Contains Pfam match to entry PF01689 Hyratase_decarb%2C Hydratase/decarboxylase. gene gene8210 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.299 SCP1.30 SCP1.30 SCP1.30 28328 28891 - hypothetical protein unknown%2C len: 187aa gene gene7939 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.30 SCP1.300 SCP1.300 SCP1.300 299431 300312 + acetaldehyde dehydrogenase catalyzes the formation of acetyl-CoA from acetalaldehyde gene gene8211 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.300 SCP1.301 SCP1.301 SCP1.301 300309 301325 + 4-hydroxy-2-oxovalerate aldolase catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid%3B involved in the degradation of phenylpropionate gene gene8212 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.301 SCP1.302 SCP1.302 SCP1.302 301322 302185 + lysase possible lysase%2C len: 287aa%3B similar to many eg. SW:P17725 (CILB_KLEPN) citrate lyase beta chain (EC 4.1.3.6) (289 aa) fasta scores%3B opt: 392%2C z-score: 446.6%2C E(): 2.1e-17%2C 31.5%25 identity in 286 aa overlap. gene gene8213 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.302 SCP1.303 SCP1.303 sapE sapE 302182 302706 + spore associated protein%2C sape spore associated protein%2C SapE%2C len: 174aa%3B similar to many of undefined function eg. TR:Q9ZC37 (EMBL:AL031866) hypothetical protein from Yersinia pestis (180 aa) fasta scores%3B opt: 490%2C z-score: 646.6%2C E(): 1.5e-28%2C 47.8%25 identity in 157 aa overlap. Contains Pfam match to entry PF01575 MaoC_dehydratas%2C MaoC like domain. gene gene8214 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.303 SCP1.304 SCP1.304 sapD sapD 302723 303925 + spore associated protein%2C sapd spore associated protein%2C SapD%2C len: 296aa gene gene8215 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.304 SCP1.305 SCP1.305 SCP1.305 304016 304906 + hypothetical protein unknown%2C len: 296aa gene gene8216 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.305 SCP1.306 SCP1.306 SCP1.306 304950 305606 + hypothetical protein unknown%2C len: 218aa%3B N-terminal region weakly similar to many eg. SW:P71311 (YAIS_ECOLI) hypothetical protein from Escherichia coli (185 aa) fasta scores%3B opt: 221%2C z-score: 290.7%2C E(): 1e-08%2C 28.7%25 identity in 164 aa overlap. gene gene8217 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.306 SCP1.307c SCP1.307c SCP1.307c 305883 306293 - hypothetical protein unknown%2C len: 136aa%3B similar to TR:Q9KY36 (EMBL:AL356892) hypothetical protein from Streptomyces coelicolor (111 aa) fasta scores%3B opt: 212%2C z-score: 263.6%2C E(): 3.3e-07%2C 37.0%25 identity in 108 aa overlap. gene gene8218 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.307c SCP1.308 SCP1.308 SCP1.308 308058 310078 + gene gene8219 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.308 SCP1.309c SCP1.309c SCP1.309c 310923 312560 - integral membrane efflux protein possible integral membrane efflux protein%2C len: 545aa%3B similar to many eg. TR:Q9XE01 (EMBL:AB019519) VarS virginiamycin S resistance protein from Streptomyces virginiae (518 aa) fasta scores%3B opt: 1001%2C z-score: 1036.6%2C E(): 0%2C 36.8%25 identity in 522 aa overlap and TR:O54186 (EMBL:AL021411) transport protein from Streptomyces coelicolor (533 aa) fasta scores%3B opt: 2830%2C z-score: 2920.7%2C E(): 0%2C 79.5%25 identity in 533 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene8220 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.309c SCP1.31 SCP1.31 SCP1.31 29125 29784 + secreted protein possible secreted protein%2C len: 219aa%3B similar to TR:Q9KY42 (EMBL:AL356892) hypothetical protein from Streptomyces coelicolor (214 aa) fasta scores%3B opt: 499%2C z-score: 600.0%2C E(): 5.9e-26%2C 41.9%25 identity in 210 aa overlap. Also strongly similar over full length to CDS SCP1.267 (fasta scores%3B opt: 1190%2C z-score: 1349.2%2C E(): 0%2C 77.5%25 identity in 218 aa overlap) and C-terminus strongly similar to its neighbouring CDS SCP1.268 (111 aa) (fasta scores%3B opt: 401%2C z-score: 463.8%2C E(): 2.6e-21%2C 57.4%25 identity in 108 aa overlap). Contains a possible cleavable N-terminal signal sequence. gene gene7940 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.31 SCP1.310c SCP1.310c SCP1.310c 312655 313671 - oxidoreductase possible oxidoreductase%2C len: 338aa%3B similar to many eg. TR:Q9RJW9 (EMBL:AL133210) reductase (fragment) from Streptomyces coelicolor (311 aa) fasta scores%3B opt: 795%2C z-score: 852.7%2C E(): 0%2C 44.0%25 identity in 293 aa overlap and SW:O82864 (AHPF_PSEPU) alkyl hydroperoxide reductase subunit from Pseudomonas putida (520 aa) fasta scores%3B opt: 301%2C z-score: 325.3%2C E(): 1.2e-10%2C 25.6%25 identity in 301 aa overlap. gene gene8221 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.310c SCP1.311c SCP1.311c SCP1.311c 314274 315089 - short chain dehydrogenase possible short-chain oxidoreductase%2C len: 271aa%3B similar to many proposed oxidoreductase eg. SW:P37959 (YUSZ_BACSU) hypothetical oxidoreductase from Bacillus subtilis (280 aa) fasta scores%3B opt: 441%2C z-score: 502.6%2C E(): 1.6e-20%2C 33.6%25 identity in 274 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site. gene gene8222 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.311c SCP1.312 SCP1.312 SCP1.312 315270 315917 + TetR family regulatory protein possible TetR-family regulator%2C len: 215aa%3B similar to many eg. TR:Q9L2D0 (EMBL:AL137187) TetR-family transcriptional regulator from Streptomyces coelicolor (194 aa) fasta scores%3B opt: 317%2C z-score: 374.6%2C E(): 2.1e-13%2C 34.5%25 identity in 206 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene8223 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.312 SCP1.313 SCP1.313 SCP1.313 316820 318055 + hypothetical protein unknown%2C len: 411aa%3B weakly similar to many eg. TR:Q9L195 (EMBL:AL158057) hypothetical protein from Streptomyces coelicolor (437 aa) fasta scores%3B opt: 476%2C z-score: 570.6%2C E(): 2.6e-24%2C 32.7%25 identity in 327 aa overlap. gene gene8224 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.313 SCP1.314 SCP1.314 SCP1.314 318859 319116 + hypothetical protein unknown%2C partial CDS%2C len: 85aa%3B appears to have been truncated by an insertion/excision event. Previously sequenced as TR:Q9L8H3 (EMBL:AF204735). Also identical to the C-terminus of the larger TR:Q54402 (EMBL:Z11519) hypothetical protein from Streptomyces lividans (336 aa) fasta scores%3B opt: 472%2C z-score: 637.5%2C E(): 4.8e-28%2C 100.0%25 identity in 73 aa overlap. gene gene8225 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.314 SCP1.315 SCP1.315 SCP1.315 319119 319538 + hypothetical protein unknown%2C len: 139aa%3B previously sequenced as TR:Q9L8H2 (EMBL:AF204735). Strongly similar to TR:Q54403 (EMBL:Z11519) hypothetical protein from transposon Tn4811 of Streptomyces lividans (138 aa) fasta scores%3B opt: 858%2C z-score: 1093.1%2C E(): 0%2C 95.7%25 identity in 139 aa overlap. gene gene8226 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.315 SCP1.316 SCP1.316 SCP1.316 319607 320569 + transposase probable transposase%2C len: 320aa%3B previously sequenced as TR:Q9L8H1 (EMBL:AF204735). Also similar to many others eg. TR:Q9R9Q9 (EMBL:AF144039) transposase from Rhizobium meliloti (Sinorhizobium meliloti) (277 aa) fasta scores%3B opt: 734%2C z-score: 824.2%2C E(): 0%2C 44.3%25 identity in 262 aa overlap. Also similar to SCP1.82 fasta scores%3B opt: 1219%2C z-score: 1504.5%2C E(): 0%2C 64.0%25 identity in 275 aa overlap. Contains Pfam match to entry PF01511 Transposase_6%2C Transposase and Pfam match to entry PF01675 Transposase_13%2C Transposase. gene gene8227 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.316 SCP1.317c SCP1.317c SCP1.317c 320862 321857 - short-chain oxidoreductase probable short-chain oxidoreductase%2C len: 331aa%3B previously sequenced as TR:Q9L8H0 (EMBL:AF204735). Also similar to many others eg. TR:Q9RR99 (EMBL:AE002088) oxidoreductase%2C short-chain dehydrogenase/reductase family from Deinococcus radiodurans (336 aa) fasta scores%3B opt: 795%2C z-score: 899.7%2C E(): 0%2C 44.7%25 identity in 320 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene8228 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.317c SCP1.318 SCP1.318 SCP1.318 321944 322858 + AraC family transcriptional regulator possible AraC-family transcriptional regulator%2C len: 304aa%3B previously sequenced as TR:Q9L8G9 (EMBL:AF204735). Similar to many eg. from streptomycetes eg. SW:Q03320 (ARAL_STRAT) AraC-like transcription regulator from Tn4811-homologous locus in Streptomyces antibioticus (303 aa) fasta scores%3B opt: 1769%2C z-score: 2065.7%2C E(): 0%2C 88.5%25 identity in 304 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C Prosite match to PS00041 Bacterial regulatory proteins%2C araC family signature and helix-turn-helix motif (Score 1345 (+3.77 SD)) at residue 216-237. gene gene8229 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.318 SCP1.319c SCP1.319c SCP1.319c 323169 323468 - hypothetical protein unknown%2C len: 99aa gene gene8230 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.319c SCP1.320c SCP1.320c SCP1.320c 323625 324563 - integral membrane protein possible conserved integral membrane protein%2C len: 312aa%3B similar to many from Streptomyces coelicolor eg. TR:O69922 (EMBL:AL023861) integral membrane protein (367 aa) fasta scores%3B opt: 613%2C z-score: 713.6%2C E(): 2.8e-32%2C 44.6%25 identity in 222 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene8231 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.320c SCP1.321 SCP1.321 SCP1.321 324753 325778 + hypothetical protein unknown%2C len: 341aa%3B similar to TR:Q9S292 (EMBL:AL096849) hypothetical protein from Streptomyces coelicolor (322 aa) fasta scores%3B opt: 620%2C z-score: 708.4%2C E(): 5.5e-32%2C 37.3%25 identity in 322 aa overlap. gene gene8232 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.321 SCP1.322 SCP1.322 SCP1.322 325805 326185 + hypothetical protein unknown%2C len: 126aa gene gene8233 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.322 SCP1.323c SCP1.323c SCP1.323c 326240 326899 - secreted protein possible secreted protein%2C len: 219aa%3B similar to TR:Q9KY42 (EMBL:AL356892) hypothetical protein from Streptomyces coelicolor (214 aa) fasta scores%3B opt: 499%2C z-score: 600.0%2C E(): 5.9e-26%2C 41.9%25 identity in 210 aa overlap. Also strongly similar over full length to CDS SCP1.267 (fasta scores%3B opt: 1190%2C z-score: 1349.2%2C E(): 0%2C 77.5%25 identity in 218 aa overlap) and C-terminus similar to its neighbouring CDS SCP1.268 (111 aa) (fasta scores%3B opt: 401%2C z-score: 463.8%2C E(): 2.6e-21%2C 57.4%25 identity in 108 aa overlap). Contains a possible cleavable N-terminal signal sequence. gene gene8234 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.323c SCP1.324 SCP1.324 SCP1.324 327133 327696 + hypothetical protein unknown%2C len: 187aa gene gene8235 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.324 SCP1.325c SCP1.325c SCP1.325c 327874 328332 - hypothetical protein unknown%2C len: 152aa gene gene8236 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.325c SCP1.326 SCP1.326 SCP1.326 329148 329501 + hypothetical protein unknown%2C len: 117aa gene gene8237 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.326 SCP1.327 SCP1.327 SCP1.327 329554 332925 + hypothetical protein unknown%2C len: 1123aa gene gene8238 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.327 SCP1.328 SCP1.328 SCP1.328 333120 333962 + hypothetical protein unknown%2C len: 280aa gene gene8239 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.328 SCP1.329 SCP1.329 SCP1.329 334686 335750 + hypothetical protein unknown%2C len: 354aa gene gene8240 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.329 SCP1.32c SCP1.32c SCP1.32c 29839 30219 - hypothetical protein unknown%2C len: 126aa gene gene7941 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.32c SCP1.330c SCP1.330c SCP1.330c 335859 336104 - hypothetical protein unknown%2C doubtful CDS%2C len: 81aa gene gene8241 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.330c SCP1.331 SCP1.331 SCP1.331 336316 336450 + hypothetical protein unknown%2C doubtful CDS%2C len: 44aa gene gene8242 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.331 SCP1.332 SCP1.332 SCP1.332 336438 336671 + hypothetical protein unknown%2C len: 77aa gene gene8243 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.332 SCP1.333 SCP1.333 SCP1.333 336746 337603 + hypothetical protein unknown%2C len: 285aa gene gene8244 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.333 SCP1.334 SCP1.334 SCP1.334 337624 338406 + hypothetical protein unknown%2C len: 260aa gene gene8245 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.334 SCP1.335 SCP1.335 SCP1.335 338412 339638 + DNA integrase/recombinase possible DNA integrase/recombinase%2C len: 408aa%3B C-terminal region weakly similar to many members of the 'phage' integrase family eg. SW:P21891 (XERD_ECOLI) integrase/recombinase XerD from Escherichia coli (298 aa) fasta scores%3B opt: 195%2C z-score: 217.2%2C E(): 0.00012%2C 28.1%25 identity in 217 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. Possible upstream and downstream alternative translational strat sites. gene gene8246 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.335 SCP1.336 SCP1.336 SCP1.336 339730 342081 + DNA integrase/recombinase possible DNA integrase/recombinase%2C len: 783aa%3B C-terminal region weakly similar to many members of the 'phage' integrase family eg. SW:P06697 (TNPB_STAAU) transposase B (transposon Tn554) from Staphylococcus aureus (630 aa) fasta scores%3B opt: 205%2C z-score: 242.4%2C E(): 4.9e-06%2C 22.1%25 identity in 280 aa overlap. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. gene gene8247 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.336 SCP1.337c SCP1.337c SCP1.337c 342117 342935 - hypothetical protein unknown%2C len: 272aa gene gene8248 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.337c SCP1.338 SCP1.338 SCP1.338 343078 343662 + hypothetical protein unknown%2C len: 194aa gene gene8249 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.338 SCP1.339c SCP1.339c SCP1.339c 344110 344334 - hypothetical protein possible membrane protein%2C len: 74aa%3B contains possible membrane-spanning hydrophobic regions. gene gene8250 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.339c SCP1.33c SCP1.33c SCP1.33c 30246 31271 - hypothetical protein unknown%2C len: 341aa%3B similar to TR:Q9S292 (EMBL:AL096849) hypothetical protein from Streptomyces coelicolor (322 aa) fasta scores%3B opt: 620%2C z-score: 708.4%2C E(): 5.5e-32%2C 37.3%25 identity in 322 aa overlap. gene gene7942 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.33c SCP1.34 SCP1.34 SCP1.34 31461 32399 + integral membrane protein possible conserved integral membrane protein%2C len: 312aa%3B similar to many from Streptomyces coelicolor eg. TR:O69922 (EMBL:AL023861) integral membrane protein (367 aa) fasta scores%3B opt: 613%2C z-score: 713.6%2C E(): 2.8e-32%2C 44.6%25 identity in 222 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene7943 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.34 SCP1.340 SCP1.340 SCP1.340 344594 345742 + hypothetical protein unknown%2C len: 382aa gene gene8251 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.340 SCP1.341 SCP1.341 SCP1.341 345775 347391 + hypothetical protein conserved hypothetical protein%2C len: 538aa%3B C-terminal similar to TR:Q9KXL1 (EMBL:AL357524) hypothetical protein from Streptomyces coelicolor (282 aa) fasta scores%3B opt: 682%2C z-score: 810.6%2C E(): 0%2C 51.1%25 identity in 235 aa overlap. Contains TTA encoded leucine at residue 154%2C possible target for bldA regulation. gene gene8252 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.341 SCP1.342 SCP1.342 SCP1.342 347434 347889 + hypothetical protein doubtful CDS%2C unknown%2C len: 151aa gene gene8253 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.342 SCP1.343 SCP1.343 SCP1.343 347886 348629 + hypothetical protein unknown%2C len: 247aa gene gene8254 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.343 SCP1.344c SCP1.344c SCP1.344c 348753 349247 - hypothetical protein unknown%2C contains tta encoded leucine at residue 33%2C possible target for bldA regulation. len: 164aa gene gene8255 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.344c SCP1.345 SCP1.345 SCP1.345 349843 350508 + hypothetical protein unknown%2C len: 221aa gene gene8256 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.345 SCP1.346 SCP1.346 SCP1.346 350584 351105 + hypothetical protein unknown%2C len: 173aa gene gene8257 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.346 SCP1.347 SCP1.347 SCP1.347 351102 351395 + hypothetical protein unknown%2C len: 97aa gene gene8258 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.347 SCP1.348 SCP1.348 SCP1.348 351392 351616 + hypothetical protein unknown%2C len: 74aa gene gene8259 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.348 SCP1.349 SCP1.349 SCP1.349 352205 352600 + hypothetical protein unknown%2C len: 131aa gene gene8260 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.349 SCP1.35 SCP1.35 SCP1.35 32556 32855 + hypothetical protein unknown%2C len: 99aa gene gene7944 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.35 SCP1.350 SCP1.350 SCP1.350 352679 352915 + hypothetical protein unknown%2C len: 78aa gene gene8261 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.350 SCP1.351 SCP1.351 SCP1.351 352903 353121 + hypothetical protein unknown%2C len: 72aa gene gene8262 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.351 SCP1.352 SCP1.352 SCP1.352 353212 354417 + hypothetical protein unknown%2C len: 401aa gene gene8263 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.352 SCP1.353 SCP1.353 SCP1.353 354502 355125 + hypothetical protein unknown%2C len: 207aa gene gene8264 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.353 SCP1.36c SCP1.36c SCP1.36c 33166 34080 - AraC family transcriptional regulator possible AraC-family transcriptional regulator%2C len: 304aa%3B previously sequenced as TR:Q9L8G9 (EMBL:AF204735). Similar to many eg. from streptomycetes eg. SW:Q03320 (ARAL_STRAT) AraC-like transcription regulator from Tn4811-homologous locus in Streptomyces antibioticus (303 aa) fasta scores%3B opt: 1769%2C z-score: 2065.7%2C E(): 0%2C 88.5%25 identity in 304 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC%2C Bacterial regulatory helix-turn-helix proteins%2C araC family%2C Prosite match to PS00041 Bacterial regulatory proteins%2C araC family signature and helix-turn-helix motif (Score 1345 (+3.77 SD)) at residue 216-237. gene gene7945 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.36c SCP1.37 SCP1.37 SCP1.37 34167 35162 + short-chain oxidoreductase probable short-chain oxidoreductase%2C len: 331aa%3B previously sequenced as TR:Q9L8H0 (EMBL:AF204735). Also similar to many others eg. TR:Q9RR99 (EMBL:AE002088) oxidoreductase%2C short-chain dehydrogenase/reductase family from Deinococcus radiodurans (336 aa) fasta scores%3B opt: 795%2C z-score: 899.7%2C E(): 0%2C 44.7%25 identity in 320 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. gene gene7946 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.37 SCP1.38c SCP1.38c SCP1.38c 35455 36417 - transposase probable transposase%2C len: 320aa%3B previously sequenced as TR:Q9L8H1 (EMBL:AF204735). Also similar to many others eg. TR:Q9R9Q9 (EMBL:AF144039) transposase from Rhizobium meliloti (Sinorhizobium meliloti) (277 aa) fasta scores%3B opt: 734%2C z-score: 824.2%2C E(): 0%2C 44.3%25 identity in 262 aa overlap. Also similar to SCP1.82 fasta scores%3B opt: 1219%2C z-score: 1504.5%2C E(): 0%2C 64.0%25 identity in 275 aa overlap. Contains Pfam match to entry PF01511 Transposase_6%2C Transposase and Pfam match to entry PF01675 Transposase_13%2C Transposase. gene gene7947 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.38c SCP1.39c SCP1.39c SCP1.39c 36486 36905 - hypothetical protein unknown%2C len: 139aa%3B previously sequenced as TR:Q9L8H2 (EMBL:AF204735). Strongly similar to TR:Q54403 (EMBL:Z11519) hypothetical protein from transposon Tn4811 of Streptomyces lividans (138 aa) fasta scores%3B opt: 858%2C z-score: 1093.1%2C E(): 0%2C 95.7%25 identity in 139 aa overlap. gene gene7948 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.39c SCP1.40c SCP1.40c SCP1.40c 36908 37165 - hypothetical protein unknown%2C partial CDS%2C len: 85aa%3B appears to have been truncated by an insertion/excision event. previously sequenced as TR:Q9L8H3 (EMBL:AF204735). Also identical to the C-terminus of the larger TR:Q54402 (EMBL:Z11519) hypothetical protein from transposon Tn4811 of Streptomyces lividans (336 aa) fasta scores%3B opt: 472%2C z-score: 637.5%2C E(): 4.8e-28%2C 100.0%25 identity in 85 aa overlap. gene gene7949 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.40c SCP1.41c SCP1.41c SCP1.41c 37969 39204 - hypothetical protein unknown%2C len: 411aa%3B weakly similar to many eg. TR:Q9L195 (EMBL:AL158057) hypothetical protein from Streptomyces coelicolor (437 aa) fasta scores%3B opt: 476%2C z-score: 570.6%2C E(): 2.6e-24%2C 32.7%25 identity in 327 aa overlap. gene gene7950 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.41c SCP1.42c SCP1.42c SCP1.42c 40107 40754 - TetR family regulatory protein possible TetR-family regulator%2C len: 215aa%3B similar to many eg. TR:Q9L2D0 (EMBL:AL137187) TetR-family transcriptional regulator from Streptomyces coelicolor (194 aa) fasta scores%3B opt: 317%2C z-score: 374.6%2C E(): 2.1e-13%2C 34.5%25 identity in 206 aa overlap. Contains Pfam match to entry PF00440 tetR%2C Bacterial regulatory proteins%2C tetR family. gene gene7951 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.42c SCP1.43 SCP1.43 SCP1.43 40935 41750 + short chain dehydrogenase possible short-chain oxidoreductase%2C len: 271aa%3B similar to many proposed oxidoreductase eg. SW:P37959 (YUSZ_BACSU) hypothetical oxidoreductase from Bacillus subtilis (280 aa) fasta scores%3B opt: 441%2C z-score: 502.6%2C E(): 1.6e-20%2C 33.6%25 identity in 274 aa overlap. Contains Pfam match to entry PF00106 adh_short%2C short chain dehydrogenase and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site. gene gene7952 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.43 SCP1.44 SCP1.44 SCP1.44 42353 43369 + oxidoreductase possible oxidoreductase%2C len: 338aa%3B similar to many eg. TR:Q9RJW9 (EMBL:AL133210) reductase (fragment) from Streptomyces coelicolor (311 aa) fasta scores%3B opt: 795%2C z-score: 852.7%2C E(): 0%2C 44.0%25 identity in 293 aa overlap and SW:O82864 (AHPF_PSEPU) alkyl hydroperoxide reductase subunit from Pseudomonas putida (520 aa) fasta scores%3B opt: 301%2C z-score: 325.3%2C E(): 1.2e-10%2C 25.6%25 identity in 301 aa overlap. gene gene7953 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.44 SCP1.45 SCP1.45 SCP1.45 43464 45101 + integral membrane efflux protein possible integral membrane efflux protein%2C len: 545aa%3B similar to many eg. TR:Q9XE01 (EMBL:AB019519) VarS virginiamycin S resistance protein from Streptomyces virginiae (518 aa) fasta scores%3B opt: 1001%2C z-score: 1036.6%2C E(): 0%2C 36.8%25 identity in 522 aa overlap and TR:O54186 (EMBL:AL021411) transport protein from Streptomyces coelicolor (533 aa) fasta scores%3B opt: 2830%2C z-score: 2920.7%2C E(): 0%2C 79.5%25 identity in 533 aa overlap. Contains multiple possible membrane-spanning hydrophobic regions. gene gene7954 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.45 SCP1.46c SCP1.46c SCP1.46c 45946 47966 - gene gene7955 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.46c SCP1.47 SCP1.47 SCP1.47 49731 50141 + hypothetical protein unknown%2C len: 136aa%3B similar to TR:Q9KY36 (EMBL:AL356892) hypothetical protein from Streptomyces coelicolor (111 aa) fasta scores%3B opt: 212%2C z-score: 263.6%2C E(): 3.3e-07%2C 37.0%25 identity in 108 aa overlap. gene gene7956 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.47 SCP1.48c SCP1.48c SCP1.48c 50418 51074 - hypothetical protein unknown%2C len: 218aa%3B N-terminal region weakly similar to many eg. SW:P71311 (YAIS_ECOLI) hypothetical protein from Escherichia coli (185 aa) fasta scores%3B opt: 221%2C z-score: 290.7%2C E(): 1e-08%2C 28.7%25 identity in 164 aa overlap. gene gene7957 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.48c SCP1.49c SCP1.49c SCP1.49c 51118 52008 - hypothetical protein unknown%2C len: 296aa gene gene7958 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.49c SCP1.50c SCP1.50c sapD sapD 52099 53301 - spore associated protein%2C sapd spore associated protein%2C SapD%2C len: 296aa gene gene7959 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.50c SCP1.51c SCP1.51c sapE sapE 53318 53842 - spore associated protein%2C sape spore associated protein%2C SapE%2C len: 174aa%3B similar to many of undefined function eg. TR:Q9ZC37 (EMBL:AL031866) hypothetical protein from Yersinia pestis (180 aa) fasta scores%3B opt: 490%2C z-score: 646.6%2C E(): 1.5e-28%2C 47.8%25 identity in 157 aa overlap. Contains Pfam match to entry PF01575 MaoC_dehydratas%2C MaoC like domain. gene gene7960 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.51c SCP1.52c SCP1.52c SCP1.52c 53839 54702 - lysase possible lysase%2C len: 287aa%3B similar to many eg. SW:P17725 (CILB_KLEPN) citrate lyase beta chain (EC 4.1.3.6) (289 aa) fasta scores%3B opt: 392%2C z-score: 446.6%2C E(): 2.1e-17%2C 31.5%25 identity in 286 aa overlap. gene gene7961 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.52c SCP1.53c SCP1.53c SCP1.53c 54699 55715 - 4-hydroxy-2-oxovalerate aldolase catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid%3B involved in the degradation of phenylpropionate gene gene7962 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.53c SCP1.54c SCP1.54c SCP1.54c 55712 56593 - acetaldehyde dehydrogenase catalyzes the formation of acetyl-CoA from acetalaldehyde gene gene7963 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.54c SCP1.55c SCP1.55c SCP1.55c 56620 57444 - hydratase probable hydratase%2C len: 274aa%3B similar to many eg. SW:P77608 (MHPD_ECOLI) 2-keto-4-pentenoate hydratase (EC 4.2.1.-) from Escherichia coli (269 aa) fasta scores%3B opt: 420%2C z-score: 525.4%2C E(): 8.5e-22%2C 34.3%25 identity in 245 aa overlap. Contains Pfam match to entry PF01689 Hyratase_decarb%2C Hydratase/decarboxylase. gene gene7964 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.55c SCP1.56c SCP1.56c sapC sapC 57441 57893 - spore associated protein%2C sapc spore associated protein%2C SapC%2C len: 150aa%3B similar to TR:Q9KYK7 (EMBL:AL356593) secreted protein from Streptomyces coelicolor (155 aa) fasta scores%3B opt: 346%2C z-score: 450.7%2C E(): 1.2e-17%2C 40.5%25 identity in 131 aa overlap. Contains a possible N-terminal signal sequence. gene gene7965 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.56c SCP1.57c SCP1.57c SCP1.57c 57923 58462 - hypothetical protein unknown%2C len: 179aa gene gene7966 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.57c SCP1.58c SCP1.58c SCP1.58c 58459 58902 - regulatory protein possible regulatory protein%2C len: 147aa%3B similar to others from Streptomyces coelicolor eg. TR:Q53897 (EMBL:X60316) AbaA pleiotropic regulatory protein from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 112%2C z-score: 149.1%2C E(): 0.77%2C 31.7%25 identity in 120 aa overlap. Contains TTA encoded leucine at residue 11%2C possible target for bldA regulation. gene gene7967 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.58c SCP1.59c SCP1.59c SCP1.59c 58920 59396 - hypothetical protein unknown%2C len: 145aa%3B similar to regions of others of undefined function eg. TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores%3B opt: 272%2C z-score: 347.5%2C E(): 6.9e-12%2C 39.4%25 identity in 127 aa overlap. gene gene7968 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.59c SCP1.60 SCP1.60 SCP1.60 59650 60522 + DNA-binding protein possible conserved DNA-binding protein%2C len: 290aa%3B similar to many from streptomycetes eg. TR:Q9RHR7 (EMBL:AB025200) ORF312 protein from plasmid pNO33 of Streptomyces albulus (285 aa) fasta scores%3B opt: 857%2C z-score: 1027.5%2C E(): 0%2C and TR:Q9KZY5 (EMBL:AL353815) DNA-binding protein from Streptomyces coelicolor (295 aa) fasta scores%3B opt: 706%2C z-score: 847.4%2C E(): 0%2C 40.8%25 identity in 282 aa overlap. Contains Pfam match to entry PF01381 HTH_3%2C Helix-turn-helix. gene gene7969 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.60 SCP1.61 SCP1.61 SCP1.61 60519 60743 + regulatory protein possible regulatory protein%2C len: 74aa%3B similar to many eg. TR:Q53896 (EMBL:X60316) AbaA pleiotropic regulatory protein from Streptomyces coelicolor (192 aa) fasta scores%3B opt: 149%2C z-score: 226.2%2C E(): 3.9e-05%2C 40.4%25 identity in 57 aa overlap and TR:Q9RHR6 (EMBL:AB025200) ORF76 protein from plasmid pNO33 of Streptomyces albulus (76 aa) fasta scores%3B opt: 309%2C z-score: 448.7%2C E(): 1.6e-17%2C 60.3%25 identity in 73 aa overlap. gene gene7970 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.61 SCP1.62 SCP1.62 SCP1.62 61144 61557 + hypothetical protein unknown%2C len: 137aa gene gene7971 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.62 SCP1.63 SCP1.63 SCP1.63 61655 63463 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 602aa%3B weakly similar to others from plasmids eg. TR:Q9XAX4 (EMBL:U88088) hypothetical protein from plasmid pRA2 of Pseudomonas alcaligenes (522 aa) fasta scores%3B opt: 263%2C z-score: 287.6%2C E(): 1.5e-08%2C 22.9%25 identity in 498 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene7972 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.63 SCP1.64c SCP1.64c SCP1.64c 63427 63702 - hypothetical protein unknown%2C len: 91aa gene gene7973 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.64c SCP1.65 SCP1.65 SCP1.65 63899 66577 + atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 892aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene7974 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.65 SCP1.66c SCP1.66c SCP1.66c 66588 66956 - hypothetical protein unknown%2C len: 122aa%3B weakly similar to TR:Q9KXJ3 (EMBL:AL357591) hypothetical protein from Streptomyces coelicolor (128 aa) fasta scores%3B opt: 102%2C z-score: 146.2%2C E(): 1.1%2C 26.7%25 identity in 120 aa overlap. gene gene7975 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.66c SCP1.67c SCP1.67c SCP1.67c 66959 67213 - hypothetical protein unknown%2C len: 84aa%3B similar to SCP1.225 hypothetical protein (previously sequenced as TR:Q9JN71 (EMBL:AJ276673)) from this plasmid fasta scores: E(): 1.1%2C 40.7%25 id in 81 aa. gene gene7976 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.67c SCP1.68 SCP1.68 SCP1.68 67553 68452 + hypothetical protein possible conserved secreted protein%2C len: 299aa%3B similar to many eg. TR:Q9XAF8 (EMBL:AL079356) hypothetical protein from Streptomyces coelicolor (365 aa) fasta scores%3B opt: 999%2C z-score: 1101.9%2C E(): 0%2C 52.8%25 identity in 303 aa overlap. Contains a possible cleavable N-terminal signal sequence gene gene7977 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.68 SCP1.69c SCP1.69c SCP1.69c 68525 68872 - hypothetical protein unknown%2C len: 115aa gene gene7978 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.69c SCP1.70c SCP1.70c SCP1.70c 69221 69385 - hypothetical protein doubtful CDS%2C unknown%2C len: 54aa gene gene7979 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.70c SCP1.71c SCP1.71c SCP1.71c 69453 69704 - hypothetical protein unknown%2C len: 115aa gene gene7980 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.71c SCP1.72c SCP1.72c SCP1.72c 69714 70379 - hypothetical protein unknown%2C len: 115aa gene gene7981 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.72c SCP1.73c SCP1.73c SCP1.73c 70445 72058 - hypothetical protein unknown%2C len: 537aa%3B weakly similar to TR:Q9L0Y7 (EMBL:AL159139) hypothetical protein from Streptomyces coelicolor (475 aa) fasta scores%3B opt: 141%2C z-score: 161.2%2C E(): 0.16%2C 26.0%25 identity in 407 aa overlap. gene gene7982 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.73c SCP1.74 SCP1.74 SCP1.74 72284 73369 + hypothetical protein unknown%2C len: 361aa gene gene7983 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.74 SCP1.75c SCP1.75c SCP1.75c 73777 74073 - hypothetical protein unknown%2C len: 98aa gene gene7984 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.75c SCP1.76c SCP1.76c SCP1.76c 74846 75391 - hypothetical protein unknown%2C len: 181aa gene gene7985 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.76c SCP1.77c SCP1.77c SCP1.77c 75615 76277 - hypothetical protein possible membrane protein%2C len: 220aa%3B note possible downstream alternative translational start sites. Contains possible membrane-spanning hydrophobic region in the N-terminal. gene gene7986 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.77c SCP1.78 SCP1.78 SCP1.78 76340 77068 + hypothetical protein unknown%2C len: 242aa%3B contains Pfam match to entry PF00583 Acetyltransf%2C Acetyltransferase (GNAT) family. gene gene7987 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.78 SCP1.79c SCP1.79c SCP1.79c 77911 82391 - gene gene7988 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.79c SCP1.80 SCP1.80 SCP1.80 78993 79994 + hypothetical protein unknown%2C len: 333aa%3B full length similarity with TR:Q54402 (EMBL:Z11519) hypothetical protein from transposable element%2C Tn4811 of Streptomyces lividans 66 (336 aa) fasta scores%3B opt: 1080%2C z-score: 1214.2%2C E(): 0%2C 49.0%25 identity in 335 aa overlap. C-terminal similar to SCP1.40c/SCP1.314 (previously sequenced as TR:Q9L8H3 (EMBL:AF204735)) (87 aa) fasta scores%3B opt: 311%2C z-score: 364.2%2C E(): 8e-13%2C 50.0%25 identity in 82 aa overlap. gene gene7989 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.80 SCP1.81 SCP1.81 SCP1.81 79999 80421 + hypothetical protein unknown%2C len: 140aa%3B similar to TR:Q54403 (EMBL:Z11519) hypothetical protein from transposable element%2C Tn4811 of Streptomyces lividans 66 (138 aa) fasta scores%3B opt: 350%2C z-score: 452.4%2C E(): 9.8e-18%2C 43.0%25 identity in 135 aa overlap. Also similar to SCP1.39c/SCP1.315 (previously sequenced as TR:Q9L8H2 (EMBL:AF204735)) (139 aa) fasta scores%3B opt: 348%2C z-score: 449.9%2C E(): 1.4e-17%2C 43.4%25 identity in 136 aa overlap. gene gene7990 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.81 SCP1.82 SCP1.82 SCP1.82 80439 81284 + transposon Tn5714 transposase probable transposon Tn5714 transposase%2C len: 281aa%3B similar to many eg. TR:Q54404 (EMBL:Z11519) from transposable element%2C Tn4811 of Streptomyces lividans 66 (320 aa) fasta scores%3B opt: 1224%2C z-score: 1510.7%2C E(): 0%2C 64.4%25 identity in 275 aa overlap and TR:Q44580 (EMBL:M98778) transposase from IS1031 element of Acetobacter xylinum. Also similar to SCP1.38c/SCP1.316 in the TIRs (previously sequenced as TR:Q9L8H1 (EMBL:AF204735)) (320 aa) fasta scores%3B opt: 1219%2C z-score: 1504.5%2C E(): 0%2C 64.0%25 identity in 275 aa overlap. Contains Pfam match to entry PF01675 Transposase_13%2C Transposase and Pfam match to entry PF01511 Transposase_6%2C Transposase. gene gene7991 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.82 SCP1.85 SCP1.85 SCP1.85 82970 83170 + hypothetical protein possible membrane protein%2C len: 439aa%3B contains possible membrane-spanning hydrophobic regions. gene gene7992 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.85 SCP1.85c SCP1.85c SCP1.85c 83371 84711 - hypothetical protein possible secreted protein%2C len: 439aa%3B contains possible cleavable N-terminal signal sequence. gene gene7993 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.85c SCP1.86 SCP1.86 SCP1.86 85408 85683 + hypothetical protein unknown%2C len: 91aa gene gene7994 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.86 SCP1.87c SCP1.87c SCP1.87c 85719 86630 - oxidoreductase possible oxidoreductase%2C len: 303aa%3B weakly similar to many eg. TR:O54079 (EMBL:AJ223781) thioredoxin reductase (EC 1.6.4.5) from Staphylococcus aureus (311 aa) fasta scores%3B opt: 250%2C z-score: 285.3%2C E(): 2e-08%2C 27.3%25 identity in 311 aa overlap. gene gene7995 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.87c SCP1.88c SCP1.88c SCP1.88c 86627 87208 - hydrolase possible hydrolase%2C len: 193aa%3B weakly similar to many eg. TR:Q9X8G0 (EMBL:AL049819) hydrolase from Streptomyces coelicolor (193 aa) fasta scores%3B opt: 177%2C z-score: 224.6%2C E(): 4.8e-05%2C 30.7%25 identity in 153 aa overlap and SW:O07900 (VIBB_VIBCH) vibriobactin-specific isochorismatase (EC 3.3.2.1) (293 aa) fasta scores%3B opt: 163%2C z-score: 205.0%2C E(): 0.0006%2C 23.9%25 identity in 180 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase%2C Isochorismatase family. gene gene7996 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.88c SCP1.89c SCP1.89c SCP1.89c 87214 88383 - hypothetical protein unknown%2C len: 389aa gene gene7997 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.89c SCP1.90c SCP1.90c SCP1.90c 88591 89277 - atp/GTP-binding protein possible ATP/GTP-binding protein%2C len: 228aa%3B contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). gene gene7998 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.90c SCP1.91c SCP1.91c SCP1.91c 89274 90032 - GntR family transcriptional regulator possible GntR-family transcriptional regulator%2C len: 252aa%3B similar to many from extrachromosomal genetic elements eg. TR:Q9RIQ2 (EMBL:AJ243257) KorA protein from plasmid pSNA1 of Streptomyces natalensis (245 aa) fasta scores%3B opt: 477%2C z-score: 554.9%2C E(): 1.9e-23%2C 37.9%25 identity in 243 aa overlap and SW:P22405 (KORA_STRLI) KorA protein from plasmid pIJ101 of Streptomyces lividans (241 aa) fasta scores%3B opt: 393%2C z-score: 459.0%2C E(): 4.3e-18%2C 34.9%25 identity in 235 aa overlap. Contains Pfam match to entry PF00392 gntR%2C Bacterial regulatory proteins%2C gntR family and helix-turn-helix motif (Score 984 (+2.54 SD)) at residue 36-57. gene gene7999 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.91c SCP1.92 SCP1.92 SCP1.92 90418 91026 + hypothetical protein unknown%2C len: 202aa gene gene8000 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.92 SCP1.93 SCP1.93 SCP1.93 91528 91956 + hypothetical protein doubtful CDS%2C unknown%2C len: 142aa gene gene8001 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.93 SCP1.94 SCP1.94 SCP1.94 92149 92322 + hypothetical protein unknown%2C len: 57aa gene gene8002 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.94 SCP1.95 SCP1.95 SCP1.95 92483 92791 + regulatory protein possible regulatory protein%2C len: 102aa%3B similar to many from actinomycets eg. TR:Q53963 (EMBL:X62287) WhiB regulatory protein from Streptomyces coelicolor (87 aa) fasta scores%3B opt: 225%2C z-score: 313.5%2C E(): 5.4e-10%2C 41.1%25 identity in 90 aa overlap and TR:Q50710 (EMBL:Z77165) regulatory protein from Mycobacterium tuberculosis (102 aa) fasta scores%3B opt: 244%2C z-score: 337.4%2C E(): 2.5e-11%2C 50.0%25 identity in 78 aa overlap. gene gene8003 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.95 SCP1.96 SCP1.96 SCP1.96 92934 93173 + hypothetical protein unknown%2C len: 79aa%3B weakly similar to TR:Q54341 (EMBL:M18244) hypothetical protein from Streptomyces limosus (Streptomyces albidoflavus) (57 aa) fasta scores%3B opt: 82%2C z-score: 132.4%2C E(): 6.6%2C 41.7%25 identity in 48 aa overlap. gene gene8004 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.96 SCP1.97 SCP1.97 SCP1.97 93231 93647 + hypothetical protein unknown%2C len: 138aa gene gene8005 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.97 SCP1.98 SCP1.98 SCP1.98 93707 95878 + large alanine-rich protein possible large ala-rich protein%2C len: 723aa%3B N-terminal half contains multiple possible coiled-coil regions. gene gene8006 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.98 SCP1.99 SCP1.99 SCP1.99 96001 96492 + hypothetical protein unknown%2C len: 163aa gene gene8007 http://www.ncbi.nlm.nih.gov/gene/?term=SCP1.99 SCP2.01 SCP2.01 SCP2.01 492 917 + putative is1648 transposase Identical to Streptomyces coelicolor putative IS1648 transposase SC3C8.15 or SC6A9.36 TR:O69927 (EMBL:AL023861) (141 aa) fasta scores: E(): 0%2C 100.0%25 id in 141 aa. Contains Pfam match to entry PF01511 Transposase_6%2C Transposase. Complete protein may be translated via a frameshift into the downstream CDS. gene gene8265 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.01 SCP2.02 SCP2.02 SCP2.02 914 1372 + putative is1648 transposase Identical to Streptomyces coelicolor putative IS1648 transposase SC3C8.16 or SC6A9.37 TR:O69928 (EMBL:AL023861) (152 aa) fasta scores: E(): 0%2C 99.3%25 id in 152 aa. Complete protein may be translated via a frameshift from the upstream CDS. gene gene8266 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.02 SCP2.04c SCP2.04c SCP2.04c 3033 4010 - hypothetical protein Unknown gene gene8267 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.04c SCP2.05c SCP2.05c parA parA 4007 4939 - putative partitioning protein para Similar to Caulobacter crescentus chromosome partitioning protein ParA SW:PARA_CAUCR (O05189) (266 aa) fasta scores: E(): 1.3e-21%2C 36.2%25 id in 257 aa%2C and to Streptomyces coelicolor ParA TR:Q9RFM1 (EMBL:AF187159) (357 aa) fasta scores: E(): 2.6e-19%2C 36.1%25 id in 263 aa. Contains Pfam match to entry PF00991 ParA%2C ParA family ATPase gene gene8268 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.05c SCP2.06 SCP2.06 SCP2.06 5557 5886 + hypothetical protein Unknown gene gene8269 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.06 SCP2.07c SCP2.07c SCP2.07c 5935 7050 - putative integrase/recombinase Similar to Agrobacterium rhizogenes Riorf136 protein%2C hypothetical integrase TR:BAB16255 (EMBL:AP002086) (383 aa) fasta scores: E(): 7.5e-18%2C 31.6%25 id in 326 aa%2C and to Pseudomonas pavonaceae putative integrase intP TR:Q9RDU9 (EMBL:AJ250371) (379 aa) fasta scores: E(): 4.8e-08%2C 28.2%25 id in 383 aa%2C and to Bacteriophage P1 recombinase Cre SW:RECR_BPP1 (P06956) (343 aa) fasta scores: E(): 0.0001%2C 24.7%25 id in 304 aa. Contains Pfam match to entry PF00589 Phage_integrase%2C Phage integrase family. gene gene8270 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.07c SCP2.08 SCP2.08 SCP2.08 7201 7386 + hypothetical protein Unknown gene gene8271 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.08 SCP2.09c SCP2.09c SCP2.09c 7612 7782 - hypothetical protein Partial CDS%2C unknown. May have been disrupted by Tn5714 insertion. gene gene8272 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.09c SCP2.10c SCP2.10c SCP2.10c 8441 9286 - putative tn5714 transposase Similar to Streptomyces lividans characteristic streptomyces coding sequence TR:Q54404 (EMBL:Z11519) (320 aa) fasta scores: E(): 0%2C 64.4%25 id in 275 aa%2C and to Streptomyces coelicolor A3 hypothetical 35.6 kDa protein TR:Q9L8H1 (EMBL:AF204735) (320 aa) fasta scores: E(): 0%2C 64.0%25 id in 275 aa%2C and to Rhizobium meliloti putative transposase tnp TR:Q9R9Q9 (EMBL:AF144039) (277 aa) fasta scores: E(): 0%2C 43.2%25 id in 266 aa%2C and to Streptomyces coelicolor transposase IS468B2 or IS468A-orf or IS468B-orf or SCJ11.27c or SC1B2.16C TR:Q9Z9H3 (EMBL:AB024596) (279 aa) fasta scores: E(): 0%2C 37.0%25 id in 276 aa. Contains Pfam match to entry PF01675 Transposase_13%2C Transposase and Pfam match to entry PF01511 Transposase_6%2C Transposase. gene gene8273 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.10c SCP2.11c SCP2.11c SCP2.11c 9304 9726 - Tn5714 hypothetical protein Similar to Streptomyces lividans characteristic streptomyces coding sequence TR:Q54403 (EMBL:Z11519) (138 aa) fasta scores: E(): 1.2e-17%2C 43.0%25 id in 135 aa%2C and to Streptomyces coelicolor A3 hypothetical 15.4 kDa protein TR:Q9L8H2 (EMBL:AF204735) (139 aa) fasta scores: E(): 1.6e-17%2C 43.4%25 id in 136 aa gene gene8274 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.11c SCP2.12c SCP2.12c SCP2.12c 9731 10732 - Tn5714 hypothetical protein Similar to Streptomyces lividans characteristic streptomyces coding sequence TR:Q54402 (EMBL:Z11519) (336 aa) fasta scores: E(): 0%2C 49.0%25 id in 335 aa%2C and to Streptomyces coelicolor A3 hypothetical 9.5 kDa protein C-terminal region only TR:Q9L8H3 (EMBL:AF204735) (87 aa) fasta scores: E(): 9.4e-13%2C 50.0%25 id in 82 aa gene gene8275 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.12c SCP2.13c SCP2.13c SCP2.13c 11298 11867 - hypothetical protein Partial CDS%2C unknown. May have been disrupted by Tn5714 insertion. gene gene8276 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.13c SCP2.14c SCP2.14c SCP2.14c 13054 14739 - putative DNA-binding protein Possible DNA-binding protein. No significant database matches. Contains helix-turn-helix motif at residue 468-489 Score 1474 (+4.21 SD). gene gene8277 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.14c SCP2.15c SCP2.15c SCP2.15c 14867 15175 - putative DNA-binding protein Possible DNA-binding protein. No significant database matches. Contains helix-turn-helix motif at residue 40-61 Score 1956 (+5.85 SD). gene gene8278 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.15c SCP2.16c SCP2.16c SCP2.16c 15261 15611 - hypothetical protein No significant database matches. gene gene8279 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.16c SCP2.17c SCP2.17c SCP2.17c 15706 15957 - hypothetical protein No significant database matches. gene gene8280 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.17c SCP2.18c SCP2.18c SCP2.18c 15954 16295 - hypothetical protein No significant database matches. gene gene8281 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.18c SCP2.19c SCP2.19c SCP2.19c 16318 16860 - hypothetical protein No significant database matches. gene gene8282 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.19c SCP2.20c SCP2.20c traA traA 16943 18379 - major plasmid transfer protein%2C traa Previously sequenced and annotated as Streptomyces coelicolor major plasmid transfer protein traA TR:Q53918 (EMBL:X90546) (478 aa) fasta scores: E(): 0%2C 100.0%25 id in 478 aa%2C and as Streptomyces coelicolor TraA protein TR:Q06256 (EMBL:X72857) (442 aa) fasta scores: E(): 0%2C 99.5%25 id in 442 aa. gene gene8283 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.20c SCP2.21c SCP2.21c traX traX 18379 19254 - plasmid transfer protein TraX Previously sequenced and annotated as Streptomyces coelicolor TraX protein TR:Q06258 (EMBL:X72857) (290 aa) fasta scores: E(): 0%2C 97.6%25 id in 291 aa. gene gene8284 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.21c SCP2.22c SCP2.22c traB traB 19332 19745 - plasmid transfer protein TraB Previously sequenced as Streptomyces coelicolor TraB protein TR:Q06257 (EMBL:X72857) (137 aa) fasta scores: E(): 0%2C 99.3%25 id in 137 aa gene gene8285 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.22c SCP2.23c SCP2.23c SCP2.23c 19751 21883 - putative glycine-rich protein Possible glycine-rich protein. No significant database matches. gene gene8286 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.23c SCP2.24c SCP2.24c SCP2.24c 22012 22269 - hypothetical protein gene gene8287 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.24c SCP2.25c SCP2.25c SCP2.25c 22266 22772 - putative alanine-rich protein Possible alanine-rich protein. No significant database matches. gene gene8288 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.25c SCP2.27c SCP2.27c SCP2.27c 23177 24778 - hypothetical protein Possible multidomain membrane protein. N-terminal half contains 4 possible membrane spanning regions. C-terminal half appears to be extra-cytoplasmic and includes an alanine-rich%2C possible coiled-coil region at residue 300-461. gene gene8289 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.27c SCP2.28c SCP2.28c SCP2.28c 24875 25078 - hypothetical protein gene gene8290 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.28c SCP2.30c SCP2.30c SCP2.30c 25224 25319 - hypothetical protein gene gene8291 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.30c SCP2.31c SCP2.31c SCP2.31c 25412 25702 - hypothetical protein gene gene8292 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.31c SCP2.32c SCP2.32c SCP2.32c 25774 26253 - hypothetical protein gene gene8293 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.32c SCP2.35 SCP2.35 SCP2.35 26665 27462 + GntR family regulatory protein Similar to many from Streptomyces eg. Streptomyces coelicolor putative gntR-family regulatory protein 2SCD46.29 TR:CAC04051 (EMBL:AL391406) (252 aa) fasta scores: E(): 3e-11%2C 27.6%25 id in 254 aa%2C and to Streptomyces ambofaciens KorsA protein korSA TR:Q07191 (EMBL:Z19589) (259 aa) fasta scores: E(): 5e-09%2C 26.4%25 id in 250 aa. Contains helix-turn-helix motif at residue 35-56. gene gene8294 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.35 SCP2.36 SCP2.36 SCP2.36 27459 27794 + hypothetical protein gene gene8295 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.36 SCP2.37 SCP2.37 SCP2.37 27897 28481 + hypothetical protein No significant database matches. Contains TTA encoded leucine at residue 14%2C possible target for bldA regulation. gene gene8296 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.37 SCP2.38c SCP2.38c SCP2.38c 28549 28959 - hypothetical protein gene gene8297 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.38c SCP2.39c SCP2.39c SCP2.39c 28965 29450 - putative regulatory protein Possible regulatory protein. Similar to Streptomyces rochei replicative protein Repl1 TR:BAB18036 (EMBL:AB034982) (150 aa) fasta scores: E(): 0.016%2C 27.9%25 id in 147 aa%2C and to Selenomonas ruminantium plasmid PONE430 TR:O50587 (EMBL:AB003193) (171 aa) fasta scores: E(): 1.8%2C 20.1%25 id in 149 aa%2C and to Streptomyces aureofaciens sporulation transcription factor whiH TR:Q9ZA83 (EMBL:AF096293) (295 aa) fasta scores: E(): 2.1%2C 26.7%25 id in 150 aa%2C and to Streptomyces coelicolor putative ROK-family regulatory protein SC8E4A.27 TR:Q9L1X8 (EMBL:AL138662) (409 aa) fasta scores: E(): 2.3%2C 28.9%25 id in 121 aa. Contains helix-turn-helix motif at residue 66-87. gene gene8298 http://www.ncbi.nlm.nih.gov/gene/?term=SCP2.39c