locus-tag	class	description
CP976_RS00025	COG2815	serine threonine protein kinase
CP976_RS00025	COG0515	serine threonine protein kinase
CP976_RS00045	COG0436	Aminotransferase
CP976_RS00050	COG2814	Major facilitator Superfamily
CP976_RS00055	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS00065	COG0077	Prephenate dehydratase
CP976_RS00130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CP976_RS00145	COG0395	ABC-type sugar transport system, permease component
CP976_RS00150	COG1175	transmembrane transport
CP976_RS00160	COG1940	carbohydrate kinase activity
CP976_RS00165	COG3335	DDE superfamily endonuclease
CP976_RS00170	COG4221	oxidoreductase activity
CP976_RS00175	COG0789	Transcriptional regulator
CP976_RS00185	COG1733	regulation of RNA biosynthetic process
CP976_RS00200	COG0583	DNA-binding transcription factor activity
CP976_RS00215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS00220	COG1116	anion transmembrane transporter activity
CP976_RS00225	COG2358	TRAP transporter, solute receptor (TAXI family
CP976_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS00245	COG0277	FAD linked oxidase domain protein
CP976_RS00250	COG0431	NADPH-dependent FMN reductase
CP976_RS00260	COG0667	Aldo Keto reductase
CP976_RS00270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP976_RS00340	COG1522	sequence-specific DNA binding
CP976_RS00345	COG0697	spore germination
CP976_RS00355	COG0596	Alpha beta hydrolase
CP976_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS00375	COG3485	protocatechuate 3,4-dioxygenase
CP976_RS00465	COG4249	Peptidase C14 caspase catalytic subunit p20
CP976_RS00465	COG2319	Wd-40 repeat
CP976_RS00490	COG1335	isochorismatase
CP976_RS00495	COG1609	Transcriptional regulator
CP976_RS00505	COG1175	transmembrane transport
CP976_RS00510	COG0395	ABC-type sugar transport system, permease component
CP976_RS00520	COG1501	Belongs to the glycosyl hydrolase 31 family
CP976_RS00525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP976_RS00535	COG0302	gtp cyclohydrolase
CP976_RS00555	COG4585	Histidine kinase
CP976_RS00560	COG2197	response regulator
CP976_RS00570	COG2814	Major facilitator Superfamily
CP976_RS00575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP976_RS00580	COG0346	lactoylglutathione lyase activity
CP976_RS00585	COG0640	Transcriptional regulator
CP976_RS00635	COG4977	sequence-specific DNA binding
CP976_RS00650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CP976_RS00665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS00695	COG3507	Belongs to the glycosyl hydrolase 43 family
CP976_RS00705	COG3345	alpha-galactosidase
CP976_RS00740	COG0574	Belongs to the PEP-utilizing enzyme family
CP976_RS00740	COG3848	Pyruvate phosphate dikinase
CP976_RS00770	COG1234	tRNA 3'-trailer cleavage
CP976_RS00775	COG0328	RNA-DNA hybrid ribonuclease activity
CP976_RS00805	COG0740	serine-type endopeptidase activity
CP976_RS00810	COG0740	serine-type endopeptidase activity
CP976_RS00815	COG1396	sequence-specific DNA binding
CP976_RS00820	COG1191	sigma factor activity
CP976_RS00865	COG0667	Aldo Keto reductase
CP976_RS00880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP976_RS00885	COG0346	lactoylglutathione lyase activity
CP976_RS00900	COG0667	Aldo Keto reductase
CP976_RS00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS00930	COG0431	NADPH-dependent FMN reductase
CP976_RS01060	COG0596	Alpha beta hydrolase
CP976_RS01070	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS01075	COG2366	antibiotic biosynthetic process
CP976_RS01090	COG2070	2-Nitropropane dioxygenase
CP976_RS01095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS01110	COG0515	serine threonine protein kinase
CP976_RS01130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP976_RS01140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS01145	COG1177	transmembrane transport
CP976_RS01155	COG3842	ATPase activity
CP976_RS01170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS01210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP976_RS01215	COG1120	ATPase activity
CP976_RS01220	COG1063	alcohol dehydrogenase
CP976_RS01225	COG2205	protein histidine kinase activity
CP976_RS01230	COG0745	RESPONSE REGULATOR receiver
CP976_RS01250	COG1309	transcriptional regulator
CP976_RS01265	COG1960	acyl-CoA dehydrogenase activity
CP976_RS01340	COG0477	Major facilitator Superfamily
CP976_RS01370	COG4221	oxidoreductase activity
CP976_RS01375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP976_RS01395	COG2376	Dihydroxyacetone kinase
CP976_RS01400	COG1461	Dihydroxyacetone kinase
CP976_RS01405	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CP976_RS01415	COG5297	Belongs to the glycosyl hydrolase family 6
CP976_RS01415	COG4733	cellulase activity
CP976_RS01430	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP976_RS01430	COG1902	pentaerythritol trinitrate reductase activity
CP976_RS01435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP976_RS01450	COG2890	protein-(glutamine-N5) methyltransferase activity
CP976_RS01460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP976_RS01475	COG3458	cephalosporin-C deacetylase activity
CP976_RS01480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS01485	COG2188	Transcriptional regulator
CP976_RS01495	COG2226	methyltransferase
CP976_RS01515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CP976_RS01520	COG1686	Belongs to the peptidase S11 family
CP976_RS01535	COG2066	Belongs to the glutaminase family
CP976_RS01550	COG1113	amino acid transport
CP976_RS01555	COG2186	Transcriptional regulator
CP976_RS01560	COG1968	undecaprenyl-diphosphatase activity
CP976_RS01565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP976_RS01570	COG1993	acr, cog1993
CP976_RS01575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP976_RS01600	COG1653	transport
CP976_RS01605	COG1175	transmembrane transport
CP976_RS01610	COG0395	ABC-type sugar transport system, permease component
CP976_RS01630	COG3340	Belongs to the peptidase S51 family
CP976_RS01660	COG1609	Transcriptional regulator
CP976_RS01680	COG0277	FAD linked oxidase domain protein
CP976_RS01680	COG0247	lactate metabolic process
CP976_RS01685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP976_RS01705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP976_RS01710	COG2151	metal-sulfur cluster biosynthetic enzyme
CP976_RS01715	COG3396	Phenylacetate-CoA oxygenase
CP976_RS01720	COG3460	Phenylacetate-CoA oxygenase
CP976_RS01725	COG3396	Phenylacetate-CoA oxygenase
CP976_RS01750	COG1609	Transcriptional regulator
CP976_RS01760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP976_RS01760	COG1024	Enoyl-CoA hydratase
CP976_RS01765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CP976_RS01775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CP976_RS01780	COG0298	carbon dioxide binding
CP976_RS01795	COG0375	protein maturation
CP976_RS01820	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CP976_RS01850	COG0281	malic enzyme
CP976_RS01855	COG1595	DNA-templated transcription, initiation
CP976_RS01920	COG2182	Extracellular solute-binding protein
CP976_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS01960	COG1301	dicarboxylic acid transport
CP976_RS01975	COG3386	PFAM SMP-30 Gluconolaconase
CP976_RS01985	COG0800	Aldolase
CP976_RS01990	COG4948	Mandelate Racemase Muconate Lactonizing
CP976_RS02015	COG1175	transmembrane transport
CP976_RS02020	COG0395	ABC-type sugar transport system, permease component
CP976_RS02030	COG3250	beta-galactosidase activity
CP976_RS02045	COG1063	alcohol dehydrogenase
CP976_RS02085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP976_RS02100	COG1136	(ABC) transporter
CP976_RS02120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP976_RS02130	COG2197	response regulator
CP976_RS02135	COG3851	Histidine kinase
CP976_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS02195	COG0789	Transcriptional regulator
CP976_RS02220	COG0667	Aldo Keto reductase
CP976_RS02225	COG0667	Aldo Keto reductase
CP976_RS02230	COG3293	Transposase
CP976_RS02240	COG2318	DinB family
CP976_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS02275	COG0745	RESPONSE REGULATOR receiver
CP976_RS02280	COG2205	protein histidine kinase activity
CP976_RS02300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP976_RS02305	COG1760	l-serine dehydratase
CP976_RS02305	COG1760	l-serine dehydratase
CP976_RS02325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP976_RS02340	COG4176	ABC-type proline glycine betaine transport system permease component
CP976_RS02345	COG0517	IMP dehydrogenase activity
CP976_RS02345	COG4175	Glycine betaine
CP976_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS02360	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CP976_RS02370	COG4638	Rieske (2fe-2S)
CP976_RS02375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP976_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS02440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP976_RS02470	COG0477	Major facilitator Superfamily
CP976_RS02475	COG0737	Belongs to the 5'-nucleotidase family
CP976_RS02480	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP976_RS02490	COG3845	ABC transporter
CP976_RS02495	COG1744	ABC transporter substrate-binding protein PnrA-like
CP976_RS02500	COG0813	purine-nucleoside phosphorylase activity
CP976_RS02510	COG1609	Transcriptional regulator
CP976_RS02515	COG0402	S-adenosylhomocysteine deaminase activity
CP976_RS02540	COG3959	Transketolase, thiamine diphosphate binding domain
CP976_RS02545	COG3958	Transketolase
CP976_RS02555	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP976_RS02565	COG1129	ABC transporter
CP976_RS02570	COG3959	Transketolase, thiamine diphosphate binding domain
CP976_RS02575	COG3958	Transketolase
CP976_RS02580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP976_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS02610	COG2315	Protein conserved in bacteria
CP976_RS02655	COG0683	leucine binding
CP976_RS02680	COG0596	Alpha beta hydrolase
CP976_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS02700	COG2197	response regulator
CP976_RS02710	COG1024	Enoyl-CoA hydratase
CP976_RS02710	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS02725	COG0778	Nitroreductase
CP976_RS02730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP976_RS02745	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CP976_RS02750	COG1301	dicarboxylic acid transport
CP976_RS02755	COG4948	Mandelate Racemase Muconate Lactonizing
CP976_RS02770	COG0784	Response regulator, receiver
CP976_RS02770	COG2205	protein histidine kinase activity
CP976_RS02770	COG5002	protein histidine kinase activity
CP976_RS02775	COG1191	sigma factor activity
CP976_RS02805	COG3250	beta-galactosidase activity
CP976_RS02815	COG1175	transmembrane transport
CP976_RS02825	COG1309	transcriptional regulator
CP976_RS02835	COG0300	oxidoreductase activity
CP976_RS02840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP976_RS02845	COG0596	Alpha beta hydrolase
CP976_RS02895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS02900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP976_RS02905	COG2080	2 iron, 2 sulfur cluster binding
CP976_RS02975	COG2814	Major facilitator Superfamily
CP976_RS02990	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS02995	COG1946	Acyl-CoA thioesterase
CP976_RS03010	COG1960	acyl-CoA dehydrogenase activity
CP976_RS03015	COG1024	Enoyl-CoA hydratase
CP976_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS03025	COG1309	transcriptional regulator
CP976_RS03030	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS03040	COG0183	Belongs to the thiolase family
CP976_RS03045	COG0596	Alpha beta hydrolase
CP976_RS03065	COG0604	alcohol dehydrogenase
CP976_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS03065	COG3321	synthase
CP976_RS03075	COG0142	geranyltranstransferase activity
CP976_RS03080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP976_RS03100	COG1132	(ABC) transporter
CP976_RS03105	COG1132	(ABC) transporter
CP976_RS03130	COG1120	ATPase activity
CP976_RS03135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP976_RS03190	COG0640	Transcriptional regulator
CP976_RS03240	COG1408	metallophosphoesterase
CP976_RS03255	COG0667	Aldo Keto reductase
CP976_RS03275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CP976_RS03275	COG3608	succinylglutamate desuccinylase aspartoacylase
CP976_RS03280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS03285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP976_RS03290	COG2080	2 iron, 2 sulfur cluster binding
CP976_RS03305	COG4974	Belongs to the 'phage' integrase family
CP976_RS03320	COG2318	DinB family
CP976_RS03345	COG0242	peptide deformylase activity
CP976_RS03350	COG0488	(ABC) transporter
CP976_RS03360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP976_RS03370	COG1609	Transcriptional regulator
CP976_RS03390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS03395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP976_RS03400	COG2080	2 iron, 2 sulfur cluster binding
CP976_RS03425	COG2814	Major facilitator Superfamily
CP976_RS03445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP976_RS03465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP976_RS03475	COG4977	sequence-specific DNA binding
CP976_RS03495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP976_RS03500	COG1881	PFAM PEBP family protein
CP976_RS03515	COG4991	sh3 domain protein
CP976_RS03535	COG2815	serine threonine protein kinase
CP976_RS03535	COG0515	serine threonine protein kinase
CP976_RS03595	COG1132	(ABC) transporter
CP976_RS03600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP976_RS03630	COG3479	Phenolic acid decarboxylase
CP976_RS03650	COG1472	Belongs to the glycosyl hydrolase 3 family
CP976_RS03660	COG1609	Transcriptional regulator
CP976_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS03690	COG2814	Major facilitator Superfamily
CP976_RS03695	COG3250	beta-galactosidase activity
CP976_RS03700	COG1309	transcriptional regulator
CP976_RS03705	COG1309	transcriptional regulator
CP976_RS03715	COG3250	beta-galactosidase activity
CP976_RS03720	COG1131	(ABC) transporter
CP976_RS03730	COG3851	Histidine kinase
CP976_RS03760	COG0640	Transcriptional regulator
CP976_RS03770	COG1960	acyl-CoA dehydrogenase activity
CP976_RS03775	COG1024	Enoyl-CoA hydratase
CP976_RS03785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP976_RS03785	COG0574	Belongs to the PEP-utilizing enzyme family
CP976_RS03790	COG1960	acyl-CoA dehydrogenase activity
CP976_RS03800	COG0183	Belongs to the thiolase family
CP976_RS03805	COG0300	oxidoreductase activity
CP976_RS03810	COG1309	transcriptional regulator
CP976_RS03820	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP976_RS03825	COG0022	dehydrogenase e1 component
CP976_RS03830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CP976_RS03840	COG4638	Rieske (2fe-2S)
CP976_RS03860	COG2130	NADP-dependent
CP976_RS03885	COG1129	ABC transporter
CP976_RS03890	COG4214	carbohydrate transport
CP976_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS03915	COG1960	acyl-CoA dehydrogenase activity
CP976_RS03930	COG0183	Belongs to the thiolase family
CP976_RS03940	COG1703	isobutyryl-CoA mutase activity
CP976_RS03940	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS03940	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS03975	COG1309	transcriptional regulator
CP976_RS03995	COG1063	alcohol dehydrogenase
CP976_RS04000	COG1024	Enoyl-CoA hydratase
CP976_RS04000	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS04025	COG2130	NADP-dependent
CP976_RS04030	COG1063	alcohol dehydrogenase
CP976_RS04045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS04110	COG1609	Transcriptional regulator
CP976_RS04120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS04125	COG0738	Major facilitator superfamily
CP976_RS04140	COG2208	phosphoserine phosphatase activity
CP976_RS04140	COG2770	Histidine kinase
CP976_RS04160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS04165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS04175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS04180	COG1126	abc transporter atp-binding protein
CP976_RS04190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS04200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS04205	COG0765	amino acid transport
CP976_RS04215	COG0745	RESPONSE REGULATOR receiver
CP976_RS04245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS04250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP976_RS04280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS04300	COG0789	Transcriptional regulator
CP976_RS04310	COG0045	succinate-CoA ligase (ADP-forming) activity
CP976_RS04325	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP976_RS04350	COG1063	alcohol dehydrogenase
CP976_RS04360	COG2226	methyltransferase
CP976_RS04365	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP976_RS04395	COG4221	oxidoreductase activity
CP976_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS04460	COG1215	transferase activity, transferring glycosyl groups
CP976_RS04495	COG1349	DNA-binding transcription factor activity
CP976_RS04540	COG3467	pyridoxamine 5'-phosphate
CP976_RS04545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP976_RS04550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP976_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS04570	COG1309	transcriptional regulator
CP976_RS04575	COG1940	carbohydrate kinase activity
CP976_RS04585	COG2813	Specifically methylates the guanine in position
CP976_RS04595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP976_RS04600	COG3387	PFAM Glycoside hydrolase 15-related
CP976_RS04610	COG2608	mercury ion transmembrane transporter activity
CP976_RS04620	COG4106	trans-aconitate 2-methyltransferase activity
CP976_RS04635	COG0395	ABC-type sugar transport system, permease component
CP976_RS04640	COG1175	transmembrane transport
CP976_RS04660	COG0673	inositol 2-dehydrogenase activity
CP976_RS04700	COG1609	Transcriptional regulator
CP976_RS04710	COG0395	ABC-type sugar transport system, permease component
CP976_RS04715	COG4209	transmembrane transport
CP976_RS04720	COG2837	iron assimilation
CP976_RS04725	COG0672	)-iron permease
CP976_RS04730	COG2207	Transcriptional regulator
CP976_RS04730	COG1609	Transcriptional regulator
CP976_RS04755	COG3594	Acyltransferase
CP976_RS04770	COG1653	transport
CP976_RS04775	COG1175	transmembrane transport
CP976_RS04810	COG0326	Molecular chaperone. Has ATPase activity
CP976_RS04835	COG0475	glutathione-regulated potassium exporter activity
CP976_RS04845	COG2814	Major facilitator Superfamily
CP976_RS04855	COG1609	Transcriptional regulator
CP976_RS04880	COG2226	methyltransferase
CP976_RS04890	COG0673	inositol 2-dehydrogenase activity
CP976_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS04950	COG2226	methyltransferase
CP976_RS04960	COG2197	response regulator
CP976_RS04965	COG4585	Histidine kinase
CP976_RS04995	COG4608	Belongs to the ABC transporter superfamily
CP976_RS05005	COG0601	transmembrane transport
CP976_RS05010	COG0747	negative chemotaxis
CP976_RS05015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP976_RS05020	COG1660	Displays ATPase and GTPase activities
CP976_RS05070	COG0515	serine threonine protein kinase
CP976_RS05070	COG2815	serine threonine protein kinase
CP976_RS05085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP976_RS05110	COG0204	Acyl-transferase
CP976_RS05140	COG0584	glycerophosphoryl diester phosphodiesterase
CP976_RS05185	COG0671	phosphoesterase, PA-phosphatase related
CP976_RS05195	COG1309	transcriptional regulator
CP976_RS05220	COG0640	Transcriptional regulator
CP976_RS05230	COG3509	depolymerase
CP976_RS05235	COG3509	depolymerase
CP976_RS05235	COG3693	PFAM glycoside hydrolase, family 10
CP976_RS05255	COG1960	acyl-CoA dehydrogenase activity
CP976_RS05275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP976_RS05315	COG1609	Transcriptional regulator
CP976_RS05370	COG1653	transport
CP976_RS05375	COG1175	transmembrane transport
CP976_RS05380	COG0395	ABC-type sugar transport system, permease component
CP976_RS05385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS05390	COG4948	Mandelate Racemase Muconate Lactonizing
CP976_RS05465	COG1222	aaa ATPase
CP976_RS05510	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS05520	COG0596	Alpha beta hydrolase
CP976_RS05525	COG1595	DNA-templated transcription, initiation
CP976_RS05540	COG3693	PFAM glycoside hydrolase, family 10
CP976_RS05550	COG1408	metallophosphoesterase
CP976_RS05560	COG0191	fructose-bisphosphate aldolase activity
CP976_RS05565	COG1349	DNA-binding transcription factor activity
CP976_RS05570	COG0395	ABC-type sugar transport system, permease component
CP976_RS05585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP976_RS05600	COG1470	cell adhesion involved in biofilm formation
CP976_RS05600	COG0366	Alpha amylase catalytic
CP976_RS05640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP976_RS05655	COG1215	transferase activity, transferring glycosyl groups
CP976_RS05665	COG4310	Domain of unknown function (DUF2172)
CP976_RS05680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP976_RS05735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP976_RS05740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP976_RS05745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP976_RS05755	COG0477	Major facilitator Superfamily
CP976_RS05765	COG0642	Histidine kinase
CP976_RS05775	COG1595	DNA-templated transcription, initiation
CP976_RS05780	COG1252	NADH dehydrogenase
CP976_RS05795	COG3842	ATPase activity
CP976_RS05825	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP976_RS05830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP976_RS05835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP976_RS05840	COG1609	Transcriptional regulator
CP976_RS05845	COG1349	DNA-binding transcription factor activity
CP976_RS05860	COG0395	ABC-type sugar transport system, permease component
CP976_RS05865	COG1063	alcohol dehydrogenase
CP976_RS05900	COG0129	dihydroxy-acid dehydratase activity
CP976_RS05905	COG1063	alcohol dehydrogenase
CP976_RS05920	COG0477	Major facilitator Superfamily
CP976_RS05925	COG0477	Major facilitator Superfamily
CP976_RS05945	COG1522	sequence-specific DNA binding
CP976_RS05950	COG1280	lysine exporter protein (LysE YggA)
CP976_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS05975	COG1846	Transcriptional regulator
CP976_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS06075	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP976_RS06105	COG0432	Pfam Uncharacterised protein family UPF0047
CP976_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS06115	COG1116	anion transmembrane transporter activity
CP976_RS06125	COG2072	flavoprotein involved in K transport
CP976_RS06130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP976_RS06135	COG1132	(ABC) transporter
CP976_RS06165	COG1132	(ABC) transporter
CP976_RS06175	COG0254	rRNA binding
CP976_RS06190	COG1946	Acyl-CoA thioesterase
CP976_RS06210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP976_RS06225	COG2018	Roadblock/LC7 domain
CP976_RS06285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP976_RS06345	COG1960	acyl-CoA dehydrogenase activity
CP976_RS06350	COG1960	acyl-CoA dehydrogenase activity
CP976_RS06360	COG3800	Transcriptional regulator
CP976_RS06360	COG1396	sequence-specific DNA binding
CP976_RS06365	COG3634	alkyl hydroperoxide reductase activity
CP976_RS06370	COG1793	dna ligase
CP976_RS06380	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS06400	COG1960	acyl-CoA dehydrogenase activity
CP976_RS06410	COG0242	peptide deformylase activity
CP976_RS06420	COG3442	glutamine amidotransferase
CP976_RS06425	COG0205	6-phosphofructokinase activity
CP976_RS06440	COG0515	serine threonine protein kinase
CP976_RS06440	COG2815	serine threonine protein kinase
CP976_RS06450	COG3275	phosphorelay sensor kinase activity
CP976_RS06455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS06465	COG3279	Response regulator of the LytR AlgR family
CP976_RS06470	COG1522	sequence-specific DNA binding
CP976_RS06475	COG1834	amidinotransferase
CP976_RS06480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP976_RS06510	COG0829	nickel cation binding
CP976_RS06515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP976_RS06525	COG0804	urea catabolic process
CP976_RS06530	COG0832	Belongs to the urease beta subunit family
CP976_RS06535	COG0831	urea catabolic process
CP976_RS06540	COG1309	transcriptional regulator
CP976_RS06555	COG0740	serine-type endopeptidase activity
CP976_RS06575	COG1280	lysine exporter protein (LysE YggA)
CP976_RS06580	COG0583	DNA-binding transcription factor activity
CP976_RS06605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP976_RS06610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP976_RS06615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP976_RS06630	COG2226	methyltransferase
CP976_RS06645	COG1136	(ABC) transporter
CP976_RS06650	COG0577	efflux transmembrane transporter activity
CP976_RS06800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP976_RS06805	COG3663	DNA glycosylase
CP976_RS06825	COG4585	Histidine kinase
CP976_RS06830	COG2197	response regulator
CP976_RS06835	COG1940	carbohydrate kinase activity
CP976_RS06840	COG2188	Transcriptional regulator
CP976_RS06845	COG1595	DNA-templated transcription, initiation
CP976_RS06860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS06875	COG0626	cystathionine gamma-synthase activity
CP976_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS06905	COG1522	sequence-specific DNA binding
CP976_RS06910	COG0419	ATPase involved in DNA repair
CP976_RS06915	COG0420	3'-5' exonuclease activity
CP976_RS06920	COG1739	Uncharacterized protein family UPF0029
CP976_RS06940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP976_RS06945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP976_RS06955	COG1832	CoA-binding protein
CP976_RS06960	COG0531	amino acid
CP976_RS06970	COG0640	Transcriptional regulator
CP976_RS06995	COG0110	maltose O-acetyltransferase activity
CP976_RS07010	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CP976_RS07040	COG2188	Transcriptional regulator
CP976_RS07135	COG0739	heme binding
CP976_RS07135	COG0741	lytic transglycosylase activity
CP976_RS07135	COG1196	nuclear chromosome segregation
CP976_RS07325	COG0494	nUDIX hydrolase
CP976_RS07510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP976_RS07520	COG0183	Belongs to the thiolase family
CP976_RS07530	COG1968	undecaprenyl-diphosphatase activity
CP976_RS07550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP976_RS07570	COG2318	DinB family
CP976_RS07585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP976_RS07590	COG0747	negative chemotaxis
CP976_RS07665	COG0697	spore germination
CP976_RS07730	COG1609	Transcriptional regulator
CP976_RS07740	COG0395	ABC-type sugar transport system, permease component
CP976_RS07745	COG1175	transmembrane transport
CP976_RS07790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP976_RS07790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP976_RS07800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP976_RS07820	COG1716	ATPase activity
CP976_RS07840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP976_RS07875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP976_RS07885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP976_RS07905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP976_RS07915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP976_RS07920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP976_RS07940	COG2018	Roadblock/LC7 domain
CP976_RS07975	COG2814	Major facilitator Superfamily
CP976_RS07980	COG4336	lyase activity
CP976_RS07985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CP976_RS07990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CP976_RS07995	COG1984	allophanate hydrolase subunit 2
CP976_RS08005	COG0438	transferase activity, transferring glycosyl groups
CP976_RS08010	COG0438	transferase activity, transferring glycosyl groups
CP976_RS08040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS08055	COG2270	Major facilitator Superfamily
CP976_RS08070	COG1216	Glycosyl transferase, family 2
CP976_RS08095	COG1960	acyl-CoA dehydrogenase activity
CP976_RS08125	COG0464	growth
CP976_RS08145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP976_RS08150	COG0140	phosphoribosyl-ATP diphosphatase activity
CP976_RS08155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP976_RS08160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP976_RS08160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP976_RS08165	COG3201	nicotinamide mononucleotide transporter
CP976_RS08175	COG1595	DNA-templated transcription, initiation
CP976_RS08180	COG1090	epimerase
CP976_RS08185	COG1846	Transcriptional regulator
CP976_RS08185	COG1940	carbohydrate kinase activity
CP976_RS08190	COG0738	Major facilitator superfamily
CP976_RS08195	COG2233	PERMEase
CP976_RS08215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP976_RS08240	COG0531	amino acid
CP976_RS08260	COG2390	Transcriptional regulator
CP976_RS08265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP976_RS08270	COG2409	Drug exporters of the RND superfamily
CP976_RS08280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP976_RS08295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP976_RS08305	COG1758	RNA polymerase activity
CP976_RS08310	COG0194	GDP metabolic process
CP976_RS08320	COG0284	orotidine-5'-phosphate decarboxylase activity
CP976_RS08325	COG0167	dihydroorotate dehydrogenase activity
CP976_RS08330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP976_RS08335	COG0505	Belongs to the CarA family
CP976_RS08345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP976_RS08350	COG0540	Belongs to the ATCase OTCase family
CP976_RS08355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CP976_RS08365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP976_RS08370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP976_RS08375	COG0006	proline dipeptidase activity
CP976_RS08385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP976_RS08390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP976_RS08395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP976_RS08405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP976_RS08420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP976_RS08425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP976_RS08440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP976_RS08460	COG0124	histidyl-tRNA synthetase
CP976_RS08470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CP976_RS08475	COG1196	nuclear chromosome segregation
CP976_RS08480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP976_RS08490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP976_RS08495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP976_RS08500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP976_RS08510	COG2255	four-way junction helicase activity
CP976_RS08515	COG0632	four-way junction helicase activity
CP976_RS08520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP976_RS08525	COG0217	transcriptional regulatory protein
CP976_RS08530	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CP976_RS08535	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CP976_RS08545	COG0438	transferase activity, transferring glycosyl groups
CP976_RS08550	COG1560	Kdo2-lipid A biosynthetic process
CP976_RS08555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP976_RS08585	COG0667	Aldo Keto reductase
CP976_RS08595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP976_RS08610	COG5002	protein histidine kinase activity
CP976_RS08610	COG2176	DNA-directed DNA polymerase activity
CP976_RS08635	COG0019	diaminopimelate decarboxylase activity
CP976_RS08655	COG0395	ABC-type sugar transport system, permease component
CP976_RS08660	COG1175	transmembrane transport
CP976_RS08710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP976_RS08765	COG2816	NAD+ diphosphatase activity
CP976_RS08775	COG1648	precorrin-2 dehydrogenase activity
CP976_RS08775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP976_RS08780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP976_RS08795	COG1464	Belongs to the NlpA lipoprotein family
CP976_RS08800	COG2011	ABC-type metal ion transport system permease component
CP976_RS08805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP976_RS08835	COG0584	glycerophosphoryl diester phosphodiesterase
CP976_RS08840	COG0204	Acyl-transferase
CP976_RS08840	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS08845	COG2205	protein histidine kinase activity
CP976_RS08850	COG0745	RESPONSE REGULATOR receiver
CP976_RS08855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP976_RS08860	COG2304	oxidoreductase activity
CP976_RS08870	COG0714	Associated with various cellular activities
CP976_RS08880	COG0477	Major facilitator Superfamily
CP976_RS08895	COG0165	Argininosuccinate lyase
CP976_RS08900	COG0137	argininosuccinate synthase activity
CP976_RS08920	COG1017	nitric oxide dioxygenase activity
CP976_RS08920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP976_RS08935	COG1438	arginine binding
CP976_RS08940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP976_RS08945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP976_RS08950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP976_RS08955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP976_RS08990	COG0697	spore germination
CP976_RS09000	COG1649	PFAM Uncharacterised BCR, COG1649
CP976_RS09035	COG0072	phenylalanine-tRNA ligase activity
CP976_RS09035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP976_RS09040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP976_RS09045	COG5002	protein histidine kinase activity
CP976_RS09050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP976_RS09055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP976_RS09060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP976_RS09065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP976_RS09105	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS09110	COG0174	glutamine synthetase
CP976_RS09115	COG2186	Transcriptional regulator
CP976_RS09120	COG0531	amino acid
CP976_RS09125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CP976_RS09150	COG4176	ABC-type proline glycine betaine transport system permease component
CP976_RS09155	COG0517	IMP dehydrogenase activity
CP976_RS09155	COG4175	Glycine betaine
CP976_RS09160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP976_RS09175	COG0564	pseudouridine synthase activity
CP976_RS09215	COG0805	protein transport
CP976_RS09220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP976_RS09240	COG2378	regulation of single-species biofilm formation
CP976_RS09250	COG0545	Peptidyl-prolyl cis-trans isomerase
CP976_RS09255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP976_RS09265	COG1609	Transcriptional regulator
CP976_RS09270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP976_RS09275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP976_RS09285	COG4122	O-methyltransferase activity
CP976_RS09290	COG1222	aaa ATPase
CP976_RS09315	COG0517	IMP dehydrogenase activity
CP976_RS09315	COG1994	Peptidase M50
CP976_RS09325	COG2197	response regulator
CP976_RS09330	COG0747	negative chemotaxis
CP976_RS09335	COG4166	transmembrane transport
CP976_RS09340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP976_RS09345	COG0646	methionine synthase
CP976_RS09345	COG1410	methionine synthase
CP976_RS09350	COG1414	Transcriptional regulator
CP976_RS09355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP976_RS09360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP976_RS09365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP976_RS09370	COG2186	Transcriptional regulator
CP976_RS09380	COG0215	cysteine-tRNA ligase activity
CP976_RS09395	COG0588	phosphoglycerate mutase activity
CP976_RS09400	COG0598	Magnesium transport protein CorA
CP976_RS09410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS09415	COG0667	Aldo Keto reductase
CP976_RS09445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP976_RS09460	COG0308	aminopeptidase N
CP976_RS09465	COG3012	SEC-C Motif Domain Protein
CP976_RS09470	COG2186	Transcriptional regulator
CP976_RS09475	COG3265	gluconokinase activity
CP976_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS09490	COG1063	alcohol dehydrogenase
CP976_RS09520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP976_RS09525	COG2149	membrane
CP976_RS09545	COG1960	acyl-CoA dehydrogenase activity
CP976_RS09555	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS09565	COG3876	Protein conserved in bacteria
CP976_RS09595	COG0789	Transcriptional regulator
CP976_RS09615	COG1960	acyl-CoA dehydrogenase activity
CP976_RS09625	COG0640	Transcriptional regulator
CP976_RS09635	COG0477	Major facilitator Superfamily
CP976_RS09670	COG2851	Citrate transporter
CP976_RS09675	COG0243	molybdopterin cofactor binding
CP976_RS09680	COG1309	transcriptional regulator
CP976_RS09690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP976_RS09695	COG2188	Transcriptional regulator
CP976_RS09730	COG1595	DNA-templated transcription, initiation
CP976_RS09750	COG0515	serine threonine protein kinase
CP976_RS09750	COG2815	serine threonine protein kinase
CP976_RS09755	COG2755	lipolytic protein G-D-S-L family
CP976_RS09770	COG1216	Glycosyl transferase, family 2
CP976_RS09790	COG1725	Transcriptional regulator
CP976_RS09835	COG0662	Cupin 2, conserved barrel domain protein
CP976_RS09835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP976_RS09840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP976_RS09845	COG0587	DNA-directed DNA polymerase activity
CP976_RS09870	COG1799	cell septum assembly
CP976_RS09875	COG1960	acyl-CoA dehydrogenase activity
CP976_RS09880	COG0477	Major facilitator Superfamily
CP976_RS09890	COG0671	phosphoesterase, PA-phosphatase related
CP976_RS09935	COG1652	LysM domain
CP976_RS09950	COG1160	GTP binding
CP976_RS09960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP976_RS09985	COG1187	pseudouridine synthase activity
CP976_RS09990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP976_RS09995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP976_RS10010	COG0686	Belongs to the AlaDH PNT family
CP976_RS10020	COG0494	nUDIX hydrolase
CP976_RS10025	COG0504	CTP synthase activity
CP976_RS10030	COG3387	PFAM Glycoside hydrolase 15-related
CP976_RS10055	COG0297	glycogen (starch) synthase activity
CP976_RS10060	COG0497	DNA recombination
CP976_RS10065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP976_RS10085	COG1120	ATPase activity
CP976_RS10090	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP976_RS10095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP976_RS10100	COG0647	UMP catabolic process
CP976_RS10135	COG2094	Belongs to the DNA glycosylase MPG family
CP976_RS10145	COG1881	PFAM PEBP family protein
CP976_RS10165	COG1119	ATPase activity
CP976_RS10180	COG2197	response regulator
CP976_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS10195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CP976_RS10205	COG0842	Transport permease protein
CP976_RS10205	COG1131	(ABC) transporter
CP976_RS10205	COG1716	ATPase activity
CP976_RS10215	COG3830	Belongs to the UPF0237 family
CP976_RS10215	COG0560	Phosphoserine phosphatase
CP976_RS10220	COG0588	phosphoglycerate mutase activity
CP976_RS10235	COG2807	transmembrane transport
CP976_RS10240	COG2186	Transcriptional regulator
CP976_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS10270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP976_RS10275	COG2261	transglycosylase associated protein
CP976_RS10290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP976_RS10300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS10355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP976_RS10370	COG1966	Carbon starvation protein
CP976_RS10395	COG3387	PFAM Glycoside hydrolase 15-related
CP976_RS10445	COG0488	(ABC) transporter
CP976_RS10465	COG0235	Class ii aldolase
CP976_RS10480	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CP976_RS10485	COG1492	cobalamin metabolic process
CP976_RS10505	COG1797	cobyrinic acid a,c-diamide synthase activity
CP976_RS10525	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CP976_RS10545	COG0765	amino acid transport
CP976_RS10550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS10555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CP976_RS10560	COG2318	DinB family
CP976_RS10565	COG0456	acetyltransferase
CP976_RS10570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP976_RS10575	COG1917	Cupin 2, conserved barrel domain protein
CP976_RS10580	COG5285	phytanoyl-CoA dioxygenase
CP976_RS10590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP976_RS10610	COG1414	Transcriptional regulator
CP976_RS10625	COG4585	Histidine kinase
CP976_RS10630	COG2197	response regulator
CP976_RS10635	COG0768	penicillin binding
CP976_RS10640	COG2252	PERMEase
CP976_RS10645	COG1595	DNA-templated transcription, initiation
CP976_RS10660	COG4733	cellulase activity
CP976_RS10680	COG4677	pectinesterase activity
CP976_RS10685	COG4677	pectinesterase activity
CP976_RS10695	COG2755	lipolytic protein G-D-S-L family
CP976_RS10705	COG4677	pectinesterase activity
CP976_RS10710	COG3507	Belongs to the glycosyl hydrolase 43 family
CP976_RS10725	COG3866	Pectate lyase
CP976_RS10730	COG0395	ABC-type sugar transport system, permease component
CP976_RS10735	COG1175	transmembrane transport
CP976_RS10745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS10750	COG1802	Transcriptional regulator
CP976_RS10780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP976_RS10800	COG0488	(ABC) transporter
CP976_RS10810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS10815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP976_RS10835	COG0395	ABC-type sugar transport system, permease component
CP976_RS10840	COG1063	alcohol dehydrogenase
CP976_RS10855	COG0596	Alpha beta hydrolase
CP976_RS10860	COG1309	transcriptional regulator
CP976_RS10865	COG0395	ABC-type sugar transport system, permease component
CP976_RS10870	COG1175	transmembrane transport
CP976_RS10880	COG1609	Transcriptional regulator
CP976_RS10895	COG1802	Transcriptional regulator
CP976_RS10940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS10950	COG2171	N-acyltransferase activity
CP976_RS10955	COG3226	Transcriptional regulator
CP976_RS10960	COG2076	Multidrug Resistance protein
CP976_RS10970	COG2151	metal-sulfur cluster biosynthetic enzyme
CP976_RS10975	COG0822	iron-sulfur transferase activity
CP976_RS10980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP976_RS10985	COG0396	ATPase activity
CP976_RS10995	COG0719	Fe-S assembly protein
CP976_RS11010	COG2746	aminoglycoside 3-N-acetyltransferase activity
CP976_RS11015	COG1131	(ABC) transporter
CP976_RS11025	COG1612	heme a metabolic process
CP976_RS11040	COG0109	protoheme IX farnesyltransferase activity
CP976_RS11055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP976_RS11070	COG0363	glucosamine-6-phosphate deaminase activity
CP976_RS11075	COG0395	ABC-type sugar transport system, permease component
CP976_RS11080	COG1175	transmembrane transport
CP976_RS11085	COG1653	transport
CP976_RS11090	COG0366	Alpha amylase catalytic
CP976_RS11100	COG1695	Transcriptional regulator
CP976_RS11105	COG1136	(ABC) transporter
CP976_RS11120	COG0166	Belongs to the GPI family
CP976_RS11130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP976_RS11135	COG0149	triose-phosphate isomerase activity
CP976_RS11140	COG0126	phosphoglycerate kinase activity
CP976_RS11145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP976_RS11155	COG1481	regulation of sporulation
CP976_RS11160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP976_RS11165	COG1660	Displays ATPase and GTPase activities
CP976_RS11170	COG0322	excinuclease ABC activity
CP976_RS11185	COG1105	Belongs to the carbohydrate kinase PfkB family
CP976_RS11200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP976_RS11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS11220	COG0765	amino acid transport
CP976_RS11230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP976_RS11235	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP976_RS11240	COG0477	Major facilitator Superfamily
CP976_RS11245	COG0387	Pfam Sodium calcium exchanger
CP976_RS11270	COG0556	nucleotide-excision repair
CP976_RS11280	COG0584	glycerophosphoryl diester phosphodiesterase
CP976_RS11285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP976_RS11295	COG2313	pseudouridylate synthase activity
CP976_RS11300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CP976_RS11300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CP976_RS11310	COG0598	Magnesium transport protein CorA
CP976_RS11340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS11345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS11375	COG1132	(ABC) transporter
CP976_RS11390	COG0402	S-adenosylhomocysteine deaminase activity
CP976_RS11400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP976_RS11430	COG1953	Uracil, thiamine, allantoin
CP976_RS11435	COG1802	Transcriptional regulator
CP976_RS11470	COG2226	methyltransferase
CP976_RS11485	COG0237	dephospho-CoA kinase activity
CP976_RS11495	COG0539	negative regulation of cytoplasmic translation
CP976_RS11510	COG1643	Atp-dependent helicase
CP976_RS11550	COG2050	protein possibly involved in aromatic compounds catabolism
CP976_RS11605	COG2968	Membrane
CP976_RS11610	COG0737	Belongs to the 5'-nucleotidase family
CP976_RS11630	COG0745	RESPONSE REGULATOR receiver
CP976_RS11640	COG0287	Prephenate dehydrogenase
CP976_RS11640	COG1605	Chorismate mutase
CP976_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS11665	COG1024	Enoyl-CoA hydratase
CP976_RS11685	COG0183	Belongs to the thiolase family
CP976_RS11690	COG1309	transcriptional regulator
CP976_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS11700	COG1960	acyl-CoA dehydrogenase activity
CP976_RS11705	COG1960	acyl-CoA dehydrogenase activity
CP976_RS11710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP976_RS11715	COG2304	oxidoreductase activity
CP976_RS11720	COG1136	(ABC) transporter
CP976_RS11720	COG4591	ABC-type transport system involved in lipoprotein release permease component
CP976_RS11750	COG0067	glutamate synthase
CP976_RS11750	COG0069	glutamate synthase activity
CP976_RS11750	COG0070	glutamate synthase
CP976_RS11760	COG1397	ADP-ribosylglycohydrolase
CP976_RS11780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP976_RS11790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP976_RS11800	COG0159	tryptophan synthase activity
CP976_RS11805	COG0133	tryptophan synthase activity
CP976_RS11815	COG0134	indole-3-glycerol-phosphate synthase activity
CP976_RS11840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP976_RS11850	COG0107	imidazoleglycerol-phosphate synthase activity
CP976_RS11855	COG0251	oxidation-reduction process
CP976_RS11860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP976_RS11865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP976_RS11870	COG0131	Imidazoleglycerol-phosphate dehydratase
CP976_RS11875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP976_RS11880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP976_RS11900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CP976_RS11920	COG1432	Conserved Protein
CP976_RS11925	COG0587	DNA-directed DNA polymerase activity
CP976_RS11980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP976_RS11995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP976_RS12000	COG3599	regulation of cell shape
CP976_RS12010	COG1799	cell septum assembly
CP976_RS12020	COG1496	oxidoreductase activity
CP976_RS12025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CP976_RS12035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP976_RS12040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP976_RS12050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP976_RS12055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP976_RS12060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CP976_RS12065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP976_RS12080	COG0275	rRNA processing
CP976_RS12090	COG0714	Associated with various cellular activities
CP976_RS12110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP976_RS12120	COG1126	abc transporter atp-binding protein
CP976_RS12130	COG1309	transcriptional regulator
CP976_RS12135	COG1233	COG1233 Phytoene dehydrogenase and related
CP976_RS12150	COG0352	thiamine-phosphate diphosphorylase activity
CP976_RS12160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP976_RS12170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS12170	COG2022	thiamine diphosphate biosynthetic process
CP976_RS12180	COG2022	thiamine diphosphate biosynthetic process
CP976_RS12185	COG2815	serine threonine protein kinase
CP976_RS12185	COG0515	serine threonine protein kinase
CP976_RS12190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CP976_RS12195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP976_RS12200	COG2193	ferroxidase activity
CP976_RS12205	COG0243	molybdopterin cofactor binding
CP976_RS12210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP976_RS12225	COG0205	6-phosphofructokinase activity
CP976_RS12230	COG2197	response regulator
CP976_RS12235	COG4585	Histidine kinase
CP976_RS12260	COG1940	carbohydrate kinase activity
CP976_RS12270	COG0003	Pfam Anion-transporting ATPase
CP976_RS12310	COG0534	Mate efflux family protein
CP976_RS12360	COG2205	protein histidine kinase activity
CP976_RS12365	COG0745	RESPONSE REGULATOR receiver
CP976_RS12375	COG1929	Belongs to the glycerate kinase type-1 family
CP976_RS12380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP976_RS12385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP976_RS12390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP976_RS12395	COG0723	plastoquinol--plastocyanin reductase activity
CP976_RS12405	COG1845	cytochrome c oxidase, subunit III
CP976_RS12415	COG1376	ErfK ybiS ycfS ynhG family protein
CP976_RS12425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP976_RS12430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP976_RS12440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS12465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CP976_RS12470	COG0515	serine threonine protein kinase
CP976_RS12470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP976_RS12475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP976_RS12480	COG2197	response regulator
CP976_RS12505	COG2226	methyltransferase
CP976_RS12520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP976_RS12525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP976_RS12540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CP976_RS12575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP976_RS12580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP976_RS12585	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP976_RS12595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP976_RS12620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP976_RS12630	COG1090	epimerase
CP976_RS12645	COG0321	lipoyl(octanoyl) transferase activity
CP976_RS12650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP976_RS12670	COG0174	glutamine synthetase
CP976_RS12685	COG0501	Belongs to the peptidase M48B family
CP976_RS12730	COG0745	RESPONSE REGULATOR receiver
CP976_RS12745	COG2197	response regulator
CP976_RS12770	COG1309	transcriptional regulator
CP976_RS12795	COG0366	Alpha amylase catalytic
CP976_RS12800	COG3833	ABC-type maltose transport systems, permease component
CP976_RS12805	COG1175	transmembrane transport
CP976_RS12815	COG1609	Transcriptional regulator
CP976_RS12835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP976_RS12870	COG0174	glutamine synthetase
CP976_RS12875	COG1017	nitric oxide dioxygenase activity
CP976_RS12875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP976_RS12880	COG1959	2 iron, 2 sulfur cluster binding
CP976_RS12905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP976_RS12905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP976_RS12910	COG3321	synthase
CP976_RS12910	COG0604	alcohol dehydrogenase
CP976_RS12915	COG2814	Major facilitator Superfamily
CP976_RS12930	COG0477	Major facilitator Superfamily
CP976_RS12935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP976_RS12955	COG1994	Peptidase M50
CP976_RS12990	COG5398	heme oxygenase
CP976_RS12995	COG0384	phenazine biosynthesis protein PhzF
CP976_RS13010	COG0584	glycerophosphoryl diester phosphodiesterase
CP976_RS13065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS13070	COG2814	Major facilitator Superfamily
CP976_RS13080	COG3540	Alkaline phosphatase
CP976_RS13090	COG0667	Aldo Keto reductase
CP976_RS13100	COG2259	Doxx family
CP976_RS13115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP976_RS13135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CP976_RS13165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CP976_RS13185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP976_RS13185	COG0515	serine threonine protein kinase
CP976_RS13190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP976_RS13200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP976_RS13255	COG0443	Heat shock 70 kDa protein
CP976_RS13350	COG1674	ftsk spoiiie
CP976_RS13390	COG3022	response to hydroperoxide
CP976_RS13395	COG0800	Aldolase
CP976_RS13410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP976_RS13430	COG2030	dehydratase
CP976_RS13450	COG0477	Major facilitator Superfamily
CP976_RS13470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP976_RS13470	COG2247	cell wall binding repeat
CP976_RS13480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS13515	COG0438	transferase activity, transferring glycosyl groups
CP976_RS13520	COG1309	transcriptional regulator
CP976_RS13575	COG3845	ABC transporter
CP976_RS13595	COG2124	cytochrome p450
CP976_RS13600	COG0183	Belongs to the thiolase family
CP976_RS13635	COG0477	Major facilitator Superfamily
CP976_RS13650	COG0477	Major facilitator Superfamily
CP976_RS13655	COG4122	O-methyltransferase activity
CP976_RS13695	COG3896	Chloramphenicol phosphotransferase-like protein
CP976_RS13725	COG2259	Doxx family
CP976_RS13740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP976_RS13745	COG1064	alcohol dehydrogenase
CP976_RS13750	COG1309	transcriptional regulator
CP976_RS13780	COG0586	Pfam SNARE associated Golgi protein
CP976_RS13790	COG1358	cellular component organization or biogenesis
CP976_RS13835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP976_RS13840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP976_RS13850	COG0477	Major facilitator Superfamily
CP976_RS13855	COG1309	transcriptional regulator
CP976_RS13870	COG0667	Aldo Keto reductase
CP976_RS13875	COG0789	Transcriptional regulator
CP976_RS13910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP976_RS13915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS13920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP976_RS13945	COG1280	lysine exporter protein (LysE YggA)
CP976_RS13965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS13970	COG1764	response to oxidative stress
CP976_RS13975	COG2130	NADP-dependent
CP976_RS14010	COG1129	ABC transporter
CP976_RS14015	COG4214	carbohydrate transport
CP976_RS14025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP976_RS14030	COG3940	Belongs to the glycosyl hydrolase 43 family
CP976_RS14035	COG3507	Belongs to the glycosyl hydrolase 43 family
CP976_RS14085	COG0395	ABC-type sugar transport system, permease component
CP976_RS14090	COG1175	transmembrane transport
CP976_RS14115	COG3386	PFAM SMP-30 Gluconolaconase
CP976_RS14120	COG1414	Transcriptional regulator
CP976_RS14150	COG4981	capsule polysaccharide biosynthetic process
CP976_RS14200	COG2186	Transcriptional regulator
CP976_RS14210	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS14215	COG0825	malonyl-CoA metabolic process
CP976_RS14215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP976_RS14230	COG2255	four-way junction helicase activity
CP976_RS14240	COG1077	Cell shape determining protein MreB Mrl
CP976_RS14285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CP976_RS14320	COG1070	Carbohydrate kinase
CP976_RS14335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP976_RS14340	COG0358	DNA primase activity
CP976_RS14350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP976_RS14360	COG2949	membrane
CP976_RS14385	COG0243	molybdopterin cofactor binding
CP976_RS14400	COG0431	NADPH-dependent FMN reductase
CP976_RS14435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP976_RS14440	COG2146	nitrite reductase [NAD(P)H] activity
CP976_RS14440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP976_RS14465	COG0659	secondary active sulfate transmembrane transporter activity
CP976_RS14475	COG0745	RESPONSE REGULATOR receiver
CP976_RS14480	COG0642	Histidine kinase
CP976_RS14500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP976_RS14500	COG0574	Belongs to the PEP-utilizing enzyme family
CP976_RS14505	COG1846	Transcriptional regulator
CP976_RS14505	COG1940	carbohydrate kinase activity
CP976_RS14510	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CP976_RS14565	COG0667	Aldo Keto reductase
CP976_RS14570	COG1280	lysine exporter protein (LysE YggA)
CP976_RS14580	COG0423	glycine-tRNA ligase activity
CP976_RS14585	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP976_RS14585	COG3443	Belongs to the bacterial solute-binding protein 9 family
CP976_RS14590	COG1121	(ABC) transporter
CP976_RS14595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP976_RS14605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP976_RS14610	COG1381	Involved in DNA repair and RecF pathway recombination
CP976_RS14635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CP976_RS14645	COG2186	Transcriptional regulator
CP976_RS14650	COG0747	negative chemotaxis
CP976_RS14665	COG4608	Belongs to the ABC transporter superfamily
CP976_RS14670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS14680	COG2197	response regulator
CP976_RS14685	COG4585	Histidine kinase
CP976_RS14690	COG2409	Drug exporters of the RND superfamily
CP976_RS14700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP976_RS14720	COG2723	6-phospho-beta-galactosidase activity
CP976_RS14745	COG1132	(ABC) transporter
CP976_RS14750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP976_RS14770	COG2315	Protein conserved in bacteria
CP976_RS14780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP976_RS14790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS14795	COG4948	Mandelate Racemase Muconate Lactonizing
CP976_RS14800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS14805	COG1414	Transcriptional regulator
CP976_RS14815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP976_RS14820	COG1234	tRNA 3'-trailer cleavage
CP976_RS14825	COG0537	adenosine 5'-monophosphoramidase activity
CP976_RS14830	COG4946	Tricorn protease homolog
CP976_RS14830	COG0793	Belongs to the peptidase S41A family
CP976_RS14850	COG0484	heat shock protein binding
CP976_RS14855	COG1420	regulation of RNA biosynthetic process
CP976_RS14880	COG4999	Histidine kinase
CP976_RS14880	COG2205	protein histidine kinase activity
CP976_RS14880	COG3437	response regulator, receiver
CP976_RS14880	COG3850	Histidine kinase
CP976_RS14895	COG0481	GTPase activity
CP976_RS14905	COG0268	Binds directly to 16S ribosomal RNA
CP976_RS14930	COG2353	YceI-like domain
CP976_RS14940	COG1234	tRNA 3'-trailer cleavage
CP976_RS14950	COG1307	EDD domain protein, DegV family
CP976_RS14960	COG0495	leucyl-tRNA aminoacylation
CP976_RS14975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP976_RS15000	COG0588	phosphoglycerate mutase activity
CP976_RS15005	COG0799	negative regulation of ribosome biogenesis
CP976_RS15015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP976_RS15020	COG0501	Belongs to the peptidase M48B family
CP976_RS15035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP976_RS15045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP976_RS15055	COG1215	transferase activity, transferring glycosyl groups
CP976_RS15070	COG3540	Alkaline phosphatase
CP976_RS15080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP976_RS15085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP976_RS15090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP976_RS15095	COG1530	ribonuclease E activity
CP976_RS15115	COG3655	Transcriptional regulator
CP976_RS15135	COG0772	Belongs to the SEDS family
CP976_RS15155	COG1077	Cell shape determining protein MreB Mrl
CP976_RS15160	COG0105	UTP biosynthetic process
CP976_RS15170	COG0285	dihydrofolate synthase activity
CP976_RS15175	COG0525	valine-tRNA ligase activity
CP976_RS15185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP976_RS15190	COG0740	serine-type endopeptidase activity
CP976_RS15195	COG0740	serine-type endopeptidase activity
CP976_RS15200	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP976_RS15215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP976_RS15215	COG0515	serine threonine protein kinase
CP976_RS15225	COG3594	Acyltransferase
CP976_RS15245	COG4552	Acetyltransferase involved in intracellular survival and related
CP976_RS15260	COG1113	amino acid transport
CP976_RS15285	COG1113	amino acid transport
CP976_RS15290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CP976_RS15305	COG1070	Carbohydrate kinase
CP976_RS15310	COG1653	transport
CP976_RS15315	COG1175	transmembrane transport
CP976_RS15320	COG0395	ABC-type sugar transport system, permease component
CP976_RS15325	COG3842	ATPase activity
CP976_RS15330	COG1349	DNA-binding transcription factor activity
CP976_RS15345	COG1070	Carbohydrate kinase
CP976_RS15350	COG0584	glycerophosphoryl diester phosphodiesterase
CP976_RS15360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP976_RS15375	COG1595	DNA-templated transcription, initiation
CP976_RS15390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP976_RS15480	COG1846	Transcriptional regulator
CP976_RS15485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP976_RS15510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP976_RS15510	COG3291	Pkd domain containing protein
CP976_RS15520	COG1136	(ABC) transporter
CP976_RS15535	COG0668	transmembrane transport
CP976_RS15545	COG1653	transport
CP976_RS15550	COG1175	transmembrane transport
CP976_RS15555	COG0395	ABC-type sugar transport system, permease component
CP976_RS15560	COG1486	melibiose metabolic process
CP976_RS15615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP976_RS15645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS15665	COG0629	single-stranded DNA binding
CP976_RS15695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP976_RS15745	COG0438	transferase activity, transferring glycosyl groups
CP976_RS15750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP976_RS15760	COG0728	peptidoglycan biosynthetic process
CP976_RS15770	COG0438	transferase activity, transferring glycosyl groups
CP976_RS15790	COG0492	ferredoxin-NADP+ reductase activity
CP976_RS15820	COG3962	Belongs to the TPP enzyme family
CP976_RS15825	COG3718	enzyme involved in inositol metabolism
CP976_RS15835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS15850	COG2409	Drug exporters of the RND superfamily
CP976_RS15880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP976_RS15895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP976_RS15915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP976_RS15935	COG1129	ABC transporter
CP976_RS15945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS15950	COG1869	D-ribose catabolic process
CP976_RS15975	COG0456	acetyltransferase
CP976_RS15975	COG1846	Transcriptional regulator
CP976_RS15985	COG2226	methyltransferase
CP976_RS15995	COG0673	inositol 2-dehydrogenase activity
CP976_RS16015	COG1472	Belongs to the glycosyl hydrolase 3 family
CP976_RS16045	COG3409	Peptidoglycan-binding domain 1 protein
CP976_RS16085	COG1946	Acyl-CoA thioesterase
CP976_RS16100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS16120	COG2326	polyphosphate kinase activity
CP976_RS16145	COG1309	transcriptional regulator
CP976_RS16150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP976_RS16165	COG1960	acyl-CoA dehydrogenase activity
CP976_RS16180	COG0076	glutamate decarboxylase activity
CP976_RS16185	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP976_RS16220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP976_RS16230	COG0589	response to stress
CP976_RS16240	COG4977	sequence-specific DNA binding
CP976_RS16245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CP976_RS16260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP976_RS16285	COG0395	ABC-type sugar transport system, permease component
CP976_RS16295	COG3345	alpha-galactosidase
CP976_RS16300	COG0395	ABC-type sugar transport system, permease component
CP976_RS16305	COG1175	transmembrane transport
CP976_RS16320	COG0745	RESPONSE REGULATOR receiver
CP976_RS16330	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP976_RS16345	COG0406	alpha-ribazole phosphatase activity
CP976_RS16405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS16430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP976_RS16435	COG0154	amidase activity
CP976_RS16445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS16450	COG0765	amino acid transport
CP976_RS16455	COG0765	amino acid transport
CP976_RS16460	COG1126	abc transporter atp-binding protein
CP976_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS16485	COG3397	chitin binding
CP976_RS16505	COG2186	Transcriptional regulator
CP976_RS16560	COG0673	inositol 2-dehydrogenase activity
CP976_RS16565	COG4702	Belongs to the UPF0303 family
CP976_RS16580	COG0706	membrane insertase activity
CP976_RS16670	COG2267	carboxylic ester hydrolase activity
CP976_RS16700	COG2733	membrane
CP976_RS16715	COG4555	ABC transporter
CP976_RS16735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP976_RS16740	COG2076	Multidrug Resistance protein
CP976_RS16775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP976_RS16785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP976_RS16790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP976_RS16795	COG1263	PTS System
CP976_RS16800	COG1234	tRNA 3'-trailer cleavage
CP976_RS16825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP976_RS16835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP976_RS16840	COG0588	phosphoglycerate mutase activity
CP976_RS16910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CP976_RS16920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP976_RS16970	COG1113	amino acid transport
CP976_RS16980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP976_RS16990	COG1335	isochorismatase
CP976_RS17035	COG0277	FAD linked oxidase domain protein
CP976_RS17045	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP976_RS17055	COG1174	glycine betaine transport
CP976_RS17065	COG1174	glycine betaine transport
CP976_RS17095	COG1061	Type III restriction enzyme res subunit
CP976_RS17100	COG3654	unkown
CP976_RS17155	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP976_RS17160	COG0395	ABC-type sugar transport system, permease component
CP976_RS17180	COG1678	Uncharacterized ACR, COG1678
CP976_RS17185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP976_RS17190	COG0776	regulation of translation
CP976_RS17200	COG3973	AAA domain
CP976_RS17225	COG2223	nitrite transmembrane transporter activity
CP976_RS17270	COG1501	Belongs to the glycosyl hydrolase 31 family
CP976_RS17275	COG1609	Transcriptional regulator
CP976_RS17285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP976_RS17290	COG0793	Belongs to the peptidase S41A family
CP976_RS17300	COG2884	Cell division ATP-binding protein ftsE
CP976_RS17315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP976_RS17320	COG0515	serine threonine protein kinase
CP976_RS17325	COG0515	serine threonine protein kinase
CP976_RS17340	COG1175	transmembrane transport
CP976_RS17345	COG0395	ABC-type sugar transport system, permease component
CP976_RS17350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP976_RS17355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP976_RS17360	COG1216	Glycosyl transferase, family 2
CP976_RS17365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CP976_RS17375	COG1764	response to oxidative stress
CP976_RS17380	COG1846	Transcriptional regulator
CP976_RS17410	COG1134	teichoic acid transport
CP976_RS17415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP976_RS17420	COG1215	transferase activity, transferring glycosyl groups
CP976_RS17435	COG2902	Dehydrogenase
CP976_RS17455	COG0653	protein targeting
CP976_RS17465	COG3214	Protein conserved in bacteria
CP976_RS17470	COG2197	response regulator
CP976_RS17475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP976_RS17485	COG0823	Involved in the tonB-independent uptake of proteins
CP976_RS17490	COG5000	phosphorelay sensor kinase activity
CP976_RS17490	COG5002	protein histidine kinase activity
CP976_RS17495	COG0745	RESPONSE REGULATOR receiver
CP976_RS17520	COG0714	Associated with various cellular activities
CP976_RS17565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP976_RS17575	COG1482	cell wall glycoprotein biosynthetic process
CP976_RS17585	COG2835	tetraacyldisaccharide 4'-kinase activity
CP976_RS17590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP976_RS17640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP976_RS17645	COG0778	Nitroreductase
CP976_RS17645	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CP976_RS17670	COG1316	TRANSCRIPTIONal
CP976_RS17675	COG1316	TRANSCRIPTIONal
CP976_RS17680	COG1316	TRANSCRIPTIONal
CP976_RS17685	COG1316	TRANSCRIPTIONal
CP976_RS17700	COG1316	TRANSCRIPTIONal
CP976_RS17710	COG1316	TRANSCRIPTIONal
CP976_RS17725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP976_RS17780	COG1902	pentaerythritol trinitrate reductase activity
CP976_RS17805	COG2205	protein histidine kinase activity
CP976_RS17810	COG0745	RESPONSE REGULATOR receiver
CP976_RS17815	COG3104	oligopeptide transport
CP976_RS17835	COG1366	Belongs to the anti-sigma-factor antagonist family
CP976_RS17840	COG1191	sigma factor activity
CP976_RS17850	COG1228	amidohydrolase
CP976_RS17865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CP976_RS17940	COG1937	Protein conserved in bacteria
CP976_RS17960	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS17975	COG2755	lipolytic protein G-D-S-L family
CP976_RS17980	COG0183	Belongs to the thiolase family
CP976_RS18015	COG1136	(ABC) transporter
CP976_RS18020	COG0577	efflux transmembrane transporter activity
CP976_RS18025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP976_RS18030	COG1252	NADH dehydrogenase
CP976_RS18050	COG0148	phosphopyruvate hydratase activity
CP976_RS18085	COG1131	(ABC) transporter
CP976_RS18100	COG3629	intracellular signal transduction
CP976_RS18110	COG2814	Major facilitator Superfamily
CP976_RS18155	COG0577	efflux transmembrane transporter activity
CP976_RS18160	COG1136	(ABC) transporter
CP976_RS18165	COG0477	Major facilitator Superfamily
CP976_RS18185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS18220	COG4585	Histidine kinase
CP976_RS18235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP976_RS18240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP976_RS18245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP976_RS18250	COG0193	aminoacyl-tRNA hydrolase activity
CP976_RS18265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CP976_RS18275	COG1309	transcriptional regulator
CP976_RS18285	COG4106	trans-aconitate 2-methyltransferase activity
CP976_RS18295	COG2197	response regulator
CP976_RS18315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP976_RS18370	COG0488	(ABC) transporter
CP976_RS18380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP976_RS18385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP976_RS18395	COG0084	hydrolase, TatD family'
CP976_RS18435	COG0310	cobalt ion transport
CP976_RS18445	COG1122	ATPase activity
CP976_RS18450	COG1846	Transcriptional regulator
CP976_RS18455	COG1764	response to oxidative stress
CP976_RS18460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS18535	COG1063	alcohol dehydrogenase
CP976_RS18540	COG2409	Drug exporters of the RND superfamily
CP976_RS18550	COG0793	Belongs to the peptidase S41A family
CP976_RS18550	COG4946	Tricorn protease homolog
CP976_RS18565	COG2267	carboxylic ester hydrolase activity
CP976_RS18570	COG2072	flavoprotein involved in K transport
CP976_RS18580	COG0708	Exodeoxyribonuclease III
CP976_RS18585	COG0454	-acetyltransferase
CP976_RS18605	COG0315	cyclic pyranopterin monophosphate synthase activity
CP976_RS18605	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP976_RS18610	COG0315	cyclic pyranopterin monophosphate synthase activity
CP976_RS18620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP976_RS18625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP976_RS18650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP976_RS18660	COG1970	mechanosensitive ion channel activity
CP976_RS18675	COG3191	aminopeptidase activity
CP976_RS18690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP976_RS18690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP976_RS18690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP976_RS18700	COG1349	DNA-binding transcription factor activity
CP976_RS18705	COG0477	Major facilitator Superfamily
CP976_RS18740	COG1247	-acetyltransferase
CP976_RS18745	COG3384	dioxygenase
CP976_RS18750	COG1846	Transcriptional regulator
CP976_RS18770	COG1414	Transcriptional regulator
CP976_RS18840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP976_RS18840	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CP976_RS18910	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP976_RS18915	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP976_RS18925	COG1879	ABC-type sugar transport system periplasmic component
CP976_RS18935	COG0697	spore germination
CP976_RS18955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CP976_RS19025	COG0386	Belongs to the glutathione peroxidase family
CP976_RS19050	COG1686	Belongs to the peptidase S11 family
CP976_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS19095	COG0693	protein deglycase activity
CP976_RS19100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP976_RS19105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP976_RS19155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP976_RS19170	COG0586	Pfam SNARE associated Golgi protein
CP976_RS19180	COG3851	Histidine kinase
CP976_RS19185	COG2197	response regulator
CP976_RS19235	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP976_RS19260	COG3903	Transcriptional regulator
CP976_RS19260	COG3629	intracellular signal transduction
CP976_RS19275	COG3386	PFAM SMP-30 Gluconolaconase
CP976_RS19295	COG1024	Enoyl-CoA hydratase
CP976_RS19300	COG2267	carboxylic ester hydrolase activity
CP976_RS19325	COG1309	transcriptional regulator
CP976_RS19335	COG1960	acyl-CoA dehydrogenase activity
CP976_RS19345	COG0076	glutamate decarboxylase activity
CP976_RS19380	COG0259	pyridoxamine-phosphate oxidase activity
CP976_RS19390	COG2072	flavoprotein involved in K transport
CP976_RS19405	COG1024	Enoyl-CoA hydratase
CP976_RS19415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CP976_RS19425	COG0583	DNA-binding transcription factor activity
CP976_RS19450	COG1960	acyl-CoA dehydrogenase activity
CP976_RS19455	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS19470	COG1960	acyl-CoA dehydrogenase activity
CP976_RS19475	COG1960	acyl-CoA dehydrogenase activity
CP976_RS19500	COG1595	DNA-templated transcription, initiation
CP976_RS19550	COG2945	thiolester hydrolase activity
CP976_RS19550	COG0596	Alpha beta hydrolase
CP976_RS19560	COG4821	SIS domain
CP976_RS19590	COG0259	pyridoxamine-phosphate oxidase activity
CP976_RS19605	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS19620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP976_RS19635	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS19640	COG1309	transcriptional regulator
CP976_RS19645	COG3467	pyridoxamine 5'-phosphate
CP976_RS19670	COG0247	lactate metabolic process
CP976_RS19670	COG0277	FAD linked oxidase domain protein
CP976_RS19675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP976_RS19680	COG2084	Dehydrogenase
CP976_RS19685	COG1309	transcriptional regulator
CP976_RS19690	COG0596	Alpha beta hydrolase
CP976_RS19705	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CP976_RS19730	COG4941	Belongs to the sigma-70 factor family
CP976_RS19735	COG3795	YCII-related domain
CP976_RS19750	COG0667	Aldo Keto reductase
CP976_RS19785	COG2252	PERMEase
CP976_RS19800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP976_RS19830	COG2814	Major facilitator Superfamily
CP976_RS19840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP976_RS19845	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP976_RS19850	COG1278	Cold shock
CP976_RS19885	COG1061	Type III restriction enzyme res subunit
CP976_RS19895	COG3973	AAA domain
CP976_RS19900	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS19940	COG1737	Transcriptional regulator
CP976_RS19945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CP976_RS19975	COG0459	protein refolding
CP976_RS19980	COG1278	Cold shock
CP976_RS19995	COG0463	Glycosyl transferase, family 2
CP976_RS20000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CP976_RS20015	COG1653	transport
CP976_RS20030	COG1105	Belongs to the carbohydrate kinase PfkB family
CP976_RS20045	COG5001	Diguanylate cyclase
CP976_RS20045	COG3300	MHYT domain
CP976_RS20130	COG2378	regulation of single-species biofilm formation
CP976_RS20135	COG3842	ATPase activity
CP976_RS20150	COG4552	Acetyltransferase involved in intracellular survival and related
CP976_RS20160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP976_RS20165	COG0215	cysteine-tRNA ligase activity
CP976_RS20170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP976_RS20175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP976_RS20180	COG1329	Transcriptional regulator
CP976_RS20200	COG5002	protein histidine kinase activity
CP976_RS20225	COG0588	phosphoglycerate mutase activity
CP976_RS20230	COG0222	ribosome binding
CP976_RS20245	COG2318	DinB family
CP976_RS20265	COG2207	Transcriptional regulator
CP976_RS20275	COG0438	transferase activity, transferring glycosyl groups
CP976_RS20365	COG0583	DNA-binding transcription factor activity
CP976_RS20400	COG1733	regulation of RNA biosynthetic process
CP976_RS20420	COG0546	phosphoglycolate phosphatase activity
CP976_RS20435	COG2188	Transcriptional regulator
CP976_RS20445	COG2186	Transcriptional regulator
CP976_RS20450	COG4552	Acetyltransferase involved in intracellular survival and related
CP976_RS20460	COG1490	D-aminoacyl-tRNA deacylase activity
CP976_RS20470	COG0735	belongs to the Fur family
CP976_RS20475	COG3485	protocatechuate 3,4-dioxygenase
CP976_RS20505	COG2897	thiosulfate sulfurtransferase activity
CP976_RS20535	COG0745	RESPONSE REGULATOR receiver
CP976_RS20540	COG1609	Transcriptional regulator
CP976_RS20545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP976_RS20555	COG0745	RESPONSE REGULATOR receiver
CP976_RS20565	COG0456	acetyltransferase
CP976_RS20570	COG0737	Belongs to the 5'-nucleotidase family
CP976_RS20655	COG1131	(ABC) transporter
CP976_RS20670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CP976_RS20680	COG0494	nUDIX hydrolase
CP976_RS20680	COG0406	alpha-ribazole phosphatase activity
CP976_RS20700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP976_RS20705	COG0306	phosphate transporter
CP976_RS20715	COG1937	Protein conserved in bacteria
CP976_RS20725	COG0277	FAD linked oxidase domain protein
CP976_RS20730	COG0671	phosphoesterase, PA-phosphatase related
CP976_RS20735	COG1196	nuclear chromosome segregation
CP976_RS20735	COG0741	lytic transglycosylase activity
CP976_RS20735	COG0739	heme binding
CP976_RS20780	COG1131	(ABC) transporter
CP976_RS20790	COG4585	Histidine kinase
CP976_RS20795	COG2197	response regulator
CP976_RS20835	COG1252	NADH dehydrogenase
CP976_RS20865	COG0579	oxidoreductase
CP976_RS20870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP976_RS20880	COG0667	Aldo Keto reductase
CP976_RS20895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP976_RS20895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP976_RS20905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP976_RS20920	COG2172	sigma factor antagonist activity
CP976_RS20925	COG1366	Belongs to the anti-sigma-factor antagonist family
CP976_RS20930	COG1366	Belongs to the anti-sigma-factor antagonist family
CP976_RS20945	COG1191	sigma factor activity
CP976_RS20975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP976_RS21015	COG0513	Belongs to the DEAD box helicase family
CP976_RS21050	COG1643	Atp-dependent helicase
CP976_RS21085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP976_RS21105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP976_RS21110	COG0047	phosphoribosylformylglycinamidine synthase activity
CP976_RS21115	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP976_RS21150	COG2197	response regulator
CP976_RS21160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP976_RS21180	COG0151	Belongs to the GarS family
CP976_RS21200	COG0640	Transcriptional regulator
CP976_RS21225	COG0328	RNA-DNA hybrid ribonuclease activity
CP976_RS21250	COG1801	Protein of unknown function DUF72
CP976_RS21275	COG2375	cellular response to nickel ion
CP976_RS21275	COG1132	(ABC) transporter
CP976_RS21305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP976_RS21340	COG1191	sigma factor activity
CP976_RS21345	COG1191	sigma factor activity
CP976_RS21365	COG2353	YceI-like domain
CP976_RS21385	COG3467	pyridoxamine 5'-phosphate
CP976_RS21395	COG0477	Major facilitator Superfamily
CP976_RS21400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CP976_RS21410	COG2205	protein histidine kinase activity
CP976_RS21415	COG0745	RESPONSE REGULATOR receiver
CP976_RS21430	COG1846	Transcriptional regulator
CP976_RS21460	COG0784	Response regulator, receiver
CP976_RS21465	COG1309	transcriptional regulator
CP976_RS21470	COG2814	Major facilitator Superfamily
CP976_RS21475	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS21480	COG1595	DNA-templated transcription, initiation
CP976_RS21525	COG4249	Peptidase C14 caspase catalytic subunit p20
CP976_RS21525	COG2319	Wd-40 repeat
CP976_RS21540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP976_RS21550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP976_RS21560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP976_RS21600	COG0006	proline dipeptidase activity
CP976_RS21640	COG2837	iron assimilation
CP976_RS21645	COG0077	Prephenate dehydratase
CP976_RS21650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP976_RS21655	COG0561	phosphatase activity
CP976_RS21685	COG1131	(ABC) transporter
CP976_RS21695	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CP976_RS21705	COG0561	phosphatase activity
CP976_RS21710	COG0739	heme binding
CP976_RS21710	COG1196	nuclear chromosome segregation
CP976_RS21710	COG0741	lytic transglycosylase activity
CP976_RS21715	COG4988	ABC transporter
CP976_RS21720	COG1294	oxidase, subunit
CP976_RS21725	COG1271	oxidase subunit
CP976_RS21735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP976_RS21740	COG1609	Transcriptional regulator
CP976_RS21755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP976_RS21780	COG0662	Cupin 2, conserved barrel domain protein
CP976_RS21785	COG1950	PFAM Membrane protein of
CP976_RS21790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP976_RS21795	COG0626	cystathionine gamma-synthase activity
CP976_RS21825	COG2814	Major facilitator Superfamily
CP976_RS21845	COG0305	Participates in initiation and elongation during chromosome replication
CP976_RS21850	COG0534	Mate efflux family protein
CP976_RS21855	COG0359	binds to the 23S rRNA
CP976_RS21860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP976_RS21865	COG0629	single-stranded DNA binding
CP976_RS21870	COG0360	Binds together with S18 to 16S ribosomal RNA
CP976_RS21895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP976_RS21920	COG0617	tRNA 3'-terminal CCA addition
CP976_RS21935	COG2815	serine threonine protein kinase
CP976_RS21935	COG0515	serine threonine protein kinase
CP976_RS21940	COG1595	DNA-templated transcription, initiation
CP976_RS21950	COG0492	ferredoxin-NADP+ reductase activity
CP976_RS21955	COG3118	belongs to the thioredoxin family
CP976_RS21970	COG1192	Involved in chromosome partitioning
CP976_RS21975	COG0357	Ribosomal RNA small subunit methyltransferase G
CP976_RS21985	COG0706	membrane insertase activity
CP976_RS21990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP976_RS21995	COG0594	ribonuclease P activity
CP976_RS22005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CP976_RS22015	COG0592	DNA-directed DNA polymerase activity
CP976_RS22020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP976_RS22025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP976_RS22030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CP976_RS22035	COG0187	DNA topoisomerase II activity
CP976_RS22040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP976_RS22070	COG0515	serine threonine protein kinase
CP976_RS22095	COG0705	Rhomboid family
CP976_RS22110	COG3764	Sortase (surface protein transpeptidase)
CP976_RS22125	COG3764	Sortase (surface protein transpeptidase)
CP976_RS22130	COG3764	Sortase (surface protein transpeptidase)
CP976_RS22135	COG0515	serine threonine protein kinase
CP976_RS22145	COG0768	penicillin binding
CP976_RS22160	COG1716	ATPase activity
CP976_RS22165	COG1716	ATPase activity
CP976_RS22245	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS22250	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS22255	COG1309	transcriptional regulator
CP976_RS22260	COG1522	sequence-specific DNA binding
CP976_RS22305	COG3321	synthase
CP976_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS22305	COG0604	alcohol dehydrogenase
CP976_RS22320	COG0515	serine threonine protein kinase
CP976_RS22325	COG0515	serine threonine protein kinase
CP976_RS22335	COG0022	dehydrogenase e1 component
CP976_RS22340	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP976_RS22345	COG3409	Peptidoglycan-binding domain 1 protein
CP976_RS22370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP976_RS22420	COG1362	aminopeptidase activity
CP976_RS22425	COG1960	acyl-CoA dehydrogenase activity
CP976_RS22445	COG0477	Major facilitator Superfamily
CP976_RS22450	COG1741	Belongs to the pirin family
CP976_RS22465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP976_RS22485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP976_RS22505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP976_RS22510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS22575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP976_RS22580	COG1280	lysine exporter protein (LysE YggA)
CP976_RS22590	COG1733	regulation of RNA biosynthetic process
CP976_RS22600	COG0701	Predicted permease
CP976_RS22620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP976_RS22625	COG1957	nucleoside hydrolase
CP976_RS22640	COG0366	Alpha amylase catalytic
CP976_RS22695	COG0583	DNA-binding transcription factor activity
CP976_RS22700	COG0768	penicillin binding
CP976_RS22705	COG2367	Beta-lactamase
CP976_RS22725	COG3250	beta-galactosidase activity
CP976_RS22760	COG2197	response regulator
CP976_RS22765	COG4585	Histidine kinase
CP976_RS22790	COG4941	Belongs to the sigma-70 factor family
CP976_RS22805	COG3903	Transcriptional regulator
CP976_RS22805	COG3629	intracellular signal transduction
CP976_RS22810	COG2267	carboxylic ester hydrolase activity
CP976_RS22835	COG1609	Transcriptional regulator
CP976_RS22845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS22855	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS22860	COG2072	flavoprotein involved in K transport
CP976_RS22870	COG0513	Belongs to the DEAD box helicase family
CP976_RS22875	COG1278	Cold shock
CP976_RS22880	COG2409	Drug exporters of the RND superfamily
CP976_RS22885	COG4585	Histidine kinase
CP976_RS22890	COG2197	response regulator
CP976_RS22900	COG2197	response regulator
CP976_RS22905	COG4585	Histidine kinase
CP976_RS22935	COG2197	response regulator
CP976_RS22945	COG0577	efflux transmembrane transporter activity
CP976_RS22945	COG1136	(ABC) transporter
CP976_RS22965	COG2319	Wd-40 repeat
CP976_RS22965	COG4249	Peptidase C14 caspase catalytic subunit p20
CP976_RS22975	COG0640	Transcriptional regulator
CP976_RS22985	COG1231	oxidoreductase activity
CP976_RS22990	COG3961	Belongs to the TPP enzyme family
CP976_RS23005	COG0583	DNA-binding transcription factor activity
CP976_RS23010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP976_RS23025	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS23030	COG1960	acyl-CoA dehydrogenase activity
CP976_RS23045	COG4977	sequence-specific DNA binding
CP976_RS23105	COG0745	RESPONSE REGULATOR receiver
CP976_RS23110	COG5002	protein histidine kinase activity
CP976_RS23185	COG0513	Belongs to the DEAD box helicase family
CP976_RS23190	COG1278	Cold shock
CP976_RS23220	COG2080	2 iron, 2 sulfur cluster binding
CP976_RS23225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP976_RS23230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS23250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP976_RS23260	COG1082	Xylose isomerase domain protein TIM barrel
CP976_RS23265	COG0596	Alpha beta hydrolase
CP976_RS23270	COG1482	cell wall glycoprotein biosynthetic process
CP976_RS23275	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS23280	COG0281	malic enzyme
CP976_RS23310	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
CP976_RS23320	COG0717	Belongs to the dCTP deaminase family
CP976_RS23325	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CP976_RS23375	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CP976_RS23420	COG2181	nitrate reductase activity
CP976_RS23420	COG0247	lactate metabolic process
CP976_RS23425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP976_RS23430	COG0443	Heat shock 70 kDa protein
CP976_RS23435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP976_RS23440	COG0484	heat shock protein binding
CP976_RS23445	COG0789	Transcriptional regulator
CP976_RS23450	COG4213	ABC transporter substrate-binding protein
CP976_RS23485	COG0542	response to heat
CP976_RS23515	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP976_RS23530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP976_RS23540	COG0477	Major facilitator Superfamily
CP976_RS23555	COG3844	kynureninase activity
CP976_RS23575	COG4585	Histidine kinase
CP976_RS23580	COG2197	response regulator
CP976_RS23585	COG4585	Histidine kinase
CP976_RS23590	COG2197	response regulator
CP976_RS23595	COG2124	cytochrome p450
CP976_RS23600	COG3559	Exporter of polyketide antibiotics
CP976_RS23605	COG1131	(ABC) transporter
CP976_RS23620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP976_RS23635	COG1802	Transcriptional regulator
CP976_RS23640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP976_RS23645	COG0693	protein deglycase activity
CP976_RS23660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP976_RS23670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP976_RS23675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP976_RS23695	COG2205	protein histidine kinase activity
CP976_RS23700	COG0745	RESPONSE REGULATOR receiver
CP976_RS23715	COG1595	DNA-templated transcription, initiation
CP976_RS23745	COG0701	Predicted permease
CP976_RS23790	COG1408	metallophosphoesterase
CP976_RS23800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP976_RS23815	COG0003	Pfam Anion-transporting ATPase
CP976_RS23840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP976_RS23875	COG2267	carboxylic ester hydrolase activity
CP976_RS23885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP976_RS23890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP976_RS23950	COG1111	helicase
CP976_RS23950	COG1205	dead DEAH box helicase
CP976_RS23955	COG1366	Belongs to the anti-sigma-factor antagonist family
CP976_RS23965	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP976_RS23985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP976_RS23985	COG1754	DNA topoisomerase type I activity
CP976_RS23990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP976_RS24035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP976_RS24060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP976_RS24085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP976_RS24090	COG0577	efflux transmembrane transporter activity
CP976_RS24095	COG1136	(ABC) transporter
CP976_RS24095	COG0577	efflux transmembrane transporter activity
CP976_RS24115	COG2197	response regulator
CP976_RS24130	COG3629	intracellular signal transduction
CP976_RS24130	COG3903	Transcriptional regulator
CP976_RS24145	COG1113	amino acid transport
CP976_RS24150	COG3708	Transcriptional regulator
CP976_RS24150	COG2207	Transcriptional regulator
CP976_RS24160	COG3629	intracellular signal transduction
CP976_RS24160	COG3903	Transcriptional regulator
CP976_RS24165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP976_RS24165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP976_RS24175	COG1280	lysine exporter protein (LysE YggA)
CP976_RS24195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP976_RS24200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP976_RS24205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP976_RS24210	COG0254	rRNA binding
CP976_RS24220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP976_RS24245	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS24250	COG2318	DinB family
CP976_RS24275	COG0076	glutamate decarboxylase activity
CP976_RS24285	COG1132	(ABC) transporter
CP976_RS24325	COG0393	Putative heavy-metal-binding
CP976_RS24330	COG0586	Pfam SNARE associated Golgi protein
CP976_RS24340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP976_RS24345	COG2027	D-alanyl-D-alanine carboxypeptidase
CP976_RS24355	COG0037	tRNA processing
CP976_RS24370	COG0302	gtp cyclohydrolase
CP976_RS24385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CP976_RS24400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP976_RS24400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP976_RS24425	COG0649	NAD binding
CP976_RS24445	COG0640	Transcriptional regulator
CP976_RS24465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP976_RS24470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP976_RS24480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP976_RS24500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CP976_RS24535	COG0739	heme binding
CP976_RS24555	COG0346	lactoylglutathione lyase activity
CP976_RS24560	COG2205	protein histidine kinase activity
CP976_RS24565	COG0745	RESPONSE REGULATOR receiver
CP976_RS24575	COG1595	DNA-templated transcription, initiation
CP976_RS24580	COG1194	a g-specific adenine glycosylase
CP976_RS24595	COG0671	phosphoesterase, PA-phosphatase related
CP976_RS24605	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CP976_RS24625	COG0248	Ppx GppA phosphatase
CP976_RS24630	COG1082	Xylose isomerase domain protein TIM barrel
CP976_RS24635	COG1309	transcriptional regulator
CP976_RS24640	COG0129	dihydroxy-acid dehydratase activity
CP976_RS24650	COG4991	sh3 domain protein
CP976_RS24670	COG0842	Transport permease protein
CP976_RS24670	COG1129	ABC transporter
CP976_RS24680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP976_RS24685	COG0180	Tryptophanyl-tRNA synthetase
CP976_RS24710	COG3866	Pectate lyase
CP976_RS24715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP976_RS24725	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP976_RS24775	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CP976_RS24780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP976_RS24785	COG0181	hydroxymethylbilane synthase activity
CP976_RS24790	COG1648	precorrin-2 dehydrogenase activity
CP976_RS24790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP976_RS24800	COG0113	porphobilinogen synthase activity
CP976_RS24825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS24840	COG2318	DinB family
CP976_RS24845	COG0018	arginyl-trna synthetase
CP976_RS24850	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP976_RS24870	COG1690	Belongs to the RtcB family
CP976_RS24885	COG1742	UPF0060 membrane protein
CP976_RS24890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS24900	COG0642	Histidine kinase
CP976_RS24900	COG3850	Histidine kinase
CP976_RS24910	COG1609	Transcriptional regulator
CP976_RS24925	COG2267	carboxylic ester hydrolase activity
CP976_RS24950	COG1309	transcriptional regulator
CP976_RS24965	COG0667	Aldo Keto reductase
CP976_RS24985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP976_RS24990	COG0406	alpha-ribazole phosphatase activity
CP976_RS25000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP976_RS25005	COG0785	Cytochrome C biogenesis protein
CP976_RS25010	COG1333	cytochrome c biogenesis protein
CP976_RS25015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP976_RS25025	COG0789	Transcriptional regulator
CP976_RS25030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP976_RS25065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CP976_RS25070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP976_RS25080	COG0163	prenyltransferase activity
CP976_RS25090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP976_RS25100	COG1573	uracil-dna glycosylase
CP976_RS25115	COG1301	dicarboxylic acid transport
CP976_RS25120	COG1309	transcriptional regulator
CP976_RS25135	COG0183	Belongs to the thiolase family
CP976_RS25145	COG4213	ABC transporter substrate-binding protein
CP976_RS25150	COG1053	succinate dehydrogenase
CP976_RS25155	COG2226	methyltransferase
CP976_RS25165	COG1278	Cold shock
CP976_RS25170	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP976_RS25185	COG0515	serine threonine protein kinase
CP976_RS25185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP976_RS25190	COG1674	ftsk spoiiie
CP976_RS25200	COG4842	Belongs to the WXG100 family
CP976_RS25300	COG0726	polysaccharide deacetylase
CP976_RS25305	COG1316	TRANSCRIPTIONal
CP976_RS25335	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CP976_RS25420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP976_RS25430	COG3979	chitinase
CP976_RS25435	COG2226	methyltransferase
CP976_RS25455	COG0242	peptide deformylase activity
CP976_RS25460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP976_RS25460	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CP976_RS25475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25480	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25485	COG0649	NAD binding
CP976_RS25495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP976_RS25500	COG1034	ATP synthesis coupled electron transport
CP976_RS25505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP976_RS25510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25515	COG0839	Belongs to the complex I subunit 6 family
CP976_RS25520	COG0713	ATP synthesis coupled electron transport
CP976_RS25525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP976_RS25535	COG1007	ATP synthesis coupled electron transport
CP976_RS25550	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP976_RS25560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS25575	COG2188	Transcriptional regulator
CP976_RS25590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP976_RS25630	COG0561	phosphatase activity
CP976_RS25640	COG0142	geranyltranstransferase activity
CP976_RS25650	COG1131	(ABC) transporter
CP976_RS25680	COG4935	Belongs to the peptidase S8 family
CP976_RS25680	COG2234	aminopeptidase activity
CP976_RS25695	COG1733	regulation of RNA biosynthetic process
CP976_RS25710	COG0702	epimerase
CP976_RS25715	COG1733	regulation of RNA biosynthetic process
CP976_RS25720	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP976_RS25725	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP976_RS25725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP976_RS25745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP976_RS25765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP976_RS25770	COG0839	Belongs to the complex I subunit 6 family
CP976_RS25775	COG0713	ATP synthesis coupled electron transport
CP976_RS25780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP976_RS25790	COG1007	ATP synthesis coupled electron transport
CP976_RS25795	COG0501	Belongs to the peptidase M48B family
CP976_RS25800	COG3304	Inner membrane component domain
CP976_RS25810	COG2261	transglycosylase associated protein
CP976_RS25815	COG1666	GTP binding
CP976_RS25835	COG0702	epimerase
CP976_RS25855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP976_RS25860	COG2030	dehydratase
CP976_RS25870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP976_RS25875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP976_RS25880	COG0436	Aminotransferase
CP976_RS25890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP976_RS25895	COG0250	Participates in transcription elongation, termination and antitermination
CP976_RS25900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP976_RS25905	COG0081	regulation of translation
CP976_RS25920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP976_RS25925	COG0222	ribosome binding
CP976_RS25935	COG0085	RNA polymerase activity
CP976_RS25940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP976_RS25950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP976_RS25955	COG0049	tRNA binding
CP976_RS25960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP976_RS25965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP976_RS26010	COG0051	transcription antitermination factor activity, RNA binding
CP976_RS26015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP976_RS26020	COG0088	Forms part of the polypeptide exit tunnel
CP976_RS26025	COG0089	rRNA binding
CP976_RS26030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP976_RS26035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP976_RS26040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP976_RS26045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP976_RS26050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP976_RS26055	COG0255	Belongs to the universal ribosomal protein uL29 family
CP976_RS26060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP976_RS26065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP976_RS26070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP976_RS26075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP976_RS26080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP976_RS26090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP976_RS26095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP976_RS26100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP976_RS26105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP976_RS26110	COG1841	ribosomal large subunit assembly
CP976_RS26115	COG0200	Binds to the 23S rRNA
CP976_RS26120	COG0201	protein transport
CP976_RS26125	COG0563	adenylate kinase activity
CP976_RS26135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP976_RS26140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP976_RS26145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP976_RS26150	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP976_RS26155	COG0202	RNA polymerase activity
CP976_RS26160	COG0203	ribosomal protein L17
CP976_RS26165	COG0101	tRNA pseudouridine synthase activity
CP976_RS26175	COG2843	Capsule synthesis protein
CP976_RS26210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP976_RS26215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP976_RS26220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP976_RS26230	COG1072	(Pantothenic acid kinase))
CP976_RS26245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP976_RS26260	COG0736	holo-[acyl-carrier-protein] synthase activity
CP976_RS26285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP976_RS26295	COG0802	atpase or kinase
CP976_RS26305	COG0456	acetyltransferase
CP976_RS26305	COG1214	PFAM Peptidase M22, glycoprotease
CP976_RS26315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP976_RS26355	COG1609	Transcriptional regulator
CP976_RS26375	COG4941	Belongs to the sigma-70 factor family
CP976_RS26385	COG0726	polysaccharide deacetylase
CP976_RS26390	COG0726	polysaccharide deacetylase
CP976_RS26400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP976_RS26405	COG0459	protein refolding
CP976_RS26415	COG4221	oxidoreductase activity
CP976_RS26425	COG0583	DNA-binding transcription factor activity
CP976_RS26440	COG1595	DNA-templated transcription, initiation
CP976_RS26450	COG0516	GMP reductase activity
CP976_RS26460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP976_RS26475	COG2815	serine threonine protein kinase
CP976_RS26475	COG0515	serine threonine protein kinase
CP976_RS26480	COG0515	serine threonine protein kinase
CP976_RS26490	COG0515	serine threonine protein kinase
CP976_RS26495	COG0515	serine threonine protein kinase
CP976_RS26500	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS26530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP976_RS26530	COG0519	Catalyzes the synthesis of GMP from XMP
CP976_RS26575	COG2197	response regulator
CP976_RS26580	COG0791	NLP P60 protein
CP976_RS26605	COG0739	heme binding
CP976_RS26615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS26615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS26635	COG0714	Associated with various cellular activities
CP976_RS26640	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CP976_RS26645	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP976_RS26655	COG0045	succinate-CoA ligase (ADP-forming) activity
CP976_RS26685	COG0138	bifunctional purine biosynthesis protein purh
CP976_RS26710	COG2815	serine threonine protein kinase
CP976_RS26710	COG0515	serine threonine protein kinase
CP976_RS26720	COG2815	serine threonine protein kinase
CP976_RS26720	COG0515	serine threonine protein kinase
CP976_RS26735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP976_RS26750	COG0039	L-malate dehydrogenase activity
CP976_RS26755	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS26765	COG0517	IMP dehydrogenase activity
CP976_RS26765	COG4175	Glycine betaine
CP976_RS26785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS26790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS26795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP976_RS26800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS26810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP976_RS26820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP976_RS26825	COG0512	Glutamine amidotransferase of anthranilate synthase
CP976_RS26825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP976_RS26845	COG0754	glutathionylspermidine amidase activity
CP976_RS26850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP976_RS26855	COG0180	Tryptophanyl-tRNA synthetase
CP976_RS26875	COG0671	phosphoesterase, PA-phosphatase related
CP976_RS26890	COG1295	ribonuclease BN
CP976_RS26895	COG1686	Belongs to the peptidase S11 family
CP976_RS26905	COG1408	metallophosphoesterase
CP976_RS26915	COG1309	transcriptional regulator
CP976_RS26950	COG1053	succinate dehydrogenase
CP976_RS26960	COG2009	succinate dehydrogenase
CP976_RS26970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP976_RS27030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS27030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS27055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP976_RS27065	COG1216	Glycosyl transferase, family 2
CP976_RS27080	COG2089	acid synthase
CP976_RS27090	COG2226	methyltransferase
CP976_RS27095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP976_RS27095	COG1473	amidohydrolase
CP976_RS27110	COG1744	ABC transporter substrate-binding protein PnrA-like
CP976_RS27115	COG1744	ABC transporter substrate-binding protein PnrA-like
CP976_RS27120	COG3845	ABC transporter
CP976_RS27130	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP976_RS27165	COG0592	DNA-directed DNA polymerase activity
CP976_RS27170	COG2814	Major facilitator Superfamily
CP976_RS27175	COG0583	DNA-binding transcription factor activity
CP976_RS27185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP976_RS27210	COG2205	protein histidine kinase activity
CP976_RS27215	COG0745	RESPONSE REGULATOR receiver
CP976_RS27220	COG1595	DNA-templated transcription, initiation
CP976_RS27235	COG0477	Major facilitator Superfamily
CP976_RS27250	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS27255	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS27270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP976_RS27300	COG4770	biotin carboxylase activity
CP976_RS27310	COG0424	maF-like protein
CP976_RS27325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP976_RS27335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP976_RS27345	COG1024	Enoyl-CoA hydratase
CP976_RS27355	COG2986	histidine ammonia-lyase
CP976_RS27380	COG1404	Belongs to the peptidase S8 family
CP976_RS27390	COG1064	alcohol dehydrogenase
CP976_RS27400	COG1090	epimerase
CP976_RS27420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP976_RS27440	COG1595	DNA-templated transcription, initiation
CP976_RS27445	COG2255	four-way junction helicase activity
CP976_RS27450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP976_RS27465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP976_RS27475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP976_RS27490	COG1331	Highly conserved protein containing a thioredoxin domain
CP976_RS27520	COG1309	transcriptional regulator
CP976_RS27530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CP976_RS27545	COG0436	Aminotransferase
CP976_RS27560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP976_RS27575	COG1414	Transcriptional regulator
CP976_RS27585	COG2610	gluconate transmembrane transporter activity
CP976_RS27660	COG2894	cell division
CP976_RS27690	COG3920	Histidine kinase
CP976_RS27825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP976_RS27835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CP976_RS27850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS27855	COG0450	alkyl hydroperoxide reductase
CP976_RS27870	COG1136	(ABC) transporter
CP976_RS27890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP976_RS27905	COG0114	fumarate hydratase activity
CP976_RS27915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CP976_RS27915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CP976_RS27940	COG0778	Nitroreductase
CP976_RS27945	COG1722	exodeoxyribonuclease VII activity
CP976_RS27950	COG1570	exodeoxyribonuclease VII activity
CP976_RS27955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP976_RS27970	COG0012	GTP binding
CP976_RS28040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP976_RS28045	COG1053	succinate dehydrogenase
CP976_RS28070	COG1217	gtp-binding protein TYPA
CP976_RS28080	COG0601	transmembrane transport
CP976_RS28085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP976_RS28095	COG4608	Belongs to the ABC transporter superfamily
CP976_RS28110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP976_RS28125	COG1131	(ABC) transporter
CP976_RS28135	COG4585	Histidine kinase
CP976_RS28140	COG2197	response regulator
CP976_RS28175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP976_RS28185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP976_RS28195	COG2818	Glycosylase
CP976_RS28200	COG1024	Enoyl-CoA hydratase
CP976_RS28215	COG1595	DNA-templated transcription, initiation
CP976_RS28225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP976_RS28230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP976_RS28265	COG0598	Magnesium transport protein CorA
CP976_RS28275	COG2814	Major facilitator Superfamily
CP976_RS28285	COG0613	PHP domain protein
CP976_RS28290	COG2095	MarC family integral membrane protein
CP976_RS28295	COG3591	Belongs to the peptidase S1B family
CP976_RS28295	COG1864	DNA RNA non-specific endonuclease
CP976_RS28305	COG1432	Conserved Protein
CP976_RS28310	COG0596	Alpha beta hydrolase
CP976_RS28360	COG0438	transferase activity, transferring glycosyl groups
CP976_RS28390	COG0494	nUDIX hydrolase
CP976_RS28455	COG0596	Alpha beta hydrolase
CP976_RS28480	COG0210	DNA helicase
CP976_RS28485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP976_RS28495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP976_RS28530	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP976_RS28585	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP976_RS28595	COG1615	UPF0182 protein
CP976_RS28625	COG0753	catalase activity
CP976_RS28635	COG0483	inositol monophosphate 1-phosphatase activity
CP976_RS28650	COG1162	GTPase activity
CP976_RS28655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP976_RS28665	COG2135	peptidase activity
CP976_RS28675	COG1595	DNA-templated transcription, initiation
CP976_RS28680	COG5662	AntiSigma factor
CP976_RS28685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CP976_RS28685	COG2199	diguanylate cyclase activity
CP976_RS28700	COG0242	peptide deformylase activity
CP976_RS28710	COG2124	cytochrome p450
CP976_RS28755	COG2188	Transcriptional regulator
CP976_RS28760	COG2182	Extracellular solute-binding protein
CP976_RS28765	COG1175	transmembrane transport
CP976_RS28770	COG0395	ABC-type sugar transport system, permease component
CP976_RS28775	COG1472	Belongs to the glycosyl hydrolase 3 family
CP976_RS28780	COG1476	TRANSCRIPTIONal
CP976_RS28790	COG0363	glucosamine-6-phosphate deaminase activity
CP976_RS28810	COG1597	lipid kinase activity
CP976_RS28840	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CP976_RS28850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP976_RS28855	COG0142	geranyltranstransferase activity
CP976_RS28885	COG4941	Belongs to the sigma-70 factor family
CP976_RS28925	COG4106	trans-aconitate 2-methyltransferase activity
CP976_RS28930	COG1126	abc transporter atp-binding protein
CP976_RS28950	COG0281	malic enzyme
CP976_RS28955	COG0604	alcohol dehydrogenase
CP976_RS28965	COG0542	response to heat
CP976_RS28990	COG0567	Dehydrogenase, E1 component
CP976_RS28990	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP976_RS28995	COG2205	protein histidine kinase activity
CP976_RS29000	COG0745	RESPONSE REGULATOR receiver
CP976_RS29005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP976_RS29020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP976_RS29035	COG5002	protein histidine kinase activity
CP976_RS29060	COG0791	NLP P60 protein
CP976_RS29060	COG3883	PFAM NLP P60 protein
CP976_RS29085	COG0768	penicillin binding
CP976_RS29100	COG2205	protein histidine kinase activity
CP976_RS29120	COG1793	dna ligase
CP976_RS29120	COG3285	dna ligase
CP976_RS29125	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP976_RS29140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CP976_RS29175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP976_RS29195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CP976_RS29215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP976_RS29240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP976_RS29280	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CP976_RS29335	COG2188	Transcriptional regulator
CP976_RS29395	COG0018	arginyl-trna synthetase
CP976_RS29400	COG0019	diaminopimelate decarboxylase activity
CP976_RS29405	COG0460	homoserine dehydrogenase
CP976_RS29410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP976_RS29415	COG0083	homoserine kinase activity
CP976_RS29435	COG0254	rRNA binding
CP976_RS29440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP976_RS29445	COG2890	protein-(glutamine-N5) methyltransferase activity
CP976_RS29455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP976_RS29460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP976_RS29465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP976_RS29480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP976_RS29485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP976_RS29490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP976_RS29495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP976_RS29500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP976_RS29505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP976_RS29510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP976_RS29525	COG2197	response regulator
CP976_RS29530	COG4585	Histidine kinase
CP976_RS29555	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS29570	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CP976_RS29625	COG0183	Belongs to the thiolase family
CP976_RS29640	COG0745	RESPONSE REGULATOR receiver
CP976_RS29715	COG2159	amidohydrolase
CP976_RS29725	COG2124	cytochrome p450
CP976_RS29745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS29745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS29785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CP976_RS29790	COG0857	belongs to the CobB CobQ family
CP976_RS29790	COG0280	phosphate acetyltransferase
CP976_RS29795	COG0205	6-phosphofructokinase activity
CP976_RS29820	COG1414	Transcriptional regulator
CP976_RS29825	COG2610	gluconate transmembrane transporter activity
CP976_RS29830	COG4948	Mandelate Racemase Muconate Lactonizing
CP976_RS29845	COG0395	ABC-type sugar transport system, permease component
CP976_RS29850	COG1175	transmembrane transport
CP976_RS29860	COG4565	transcriptional regulatory protein
CP976_RS29865	COG3290	protein histidine kinase activity
CP976_RS29870	COG1301	dicarboxylic acid transport
CP976_RS29880	COG0477	Major facilitator Superfamily
CP976_RS29885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP976_RS29890	COG0667	Aldo Keto reductase
CP976_RS29900	COG1522	sequence-specific DNA binding
CP976_RS29910	COG0492	ferredoxin-NADP+ reductase activity
CP976_RS29910	COG3118	belongs to the thioredoxin family
CP976_RS29920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP976_RS29925	COG3281	Trehalose synthase
CP976_RS29945	COG0058	SHG alpha-glucan phosphorylase activity
CP976_RS29965	COG1132	(ABC) transporter
CP976_RS29970	COG1132	(ABC) transporter
CP976_RS29975	COG1132	(ABC) transporter
CP976_RS29980	COG1132	(ABC) transporter
CP976_RS29985	COG1131	(ABC) transporter
CP976_RS29995	COG4585	Histidine kinase
CP976_RS30000	COG2197	response regulator
CP976_RS30010	COG0477	Major facilitator Superfamily
CP976_RS30030	COG0667	Aldo Keto reductase
CP976_RS30040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS30075	COG1376	ErfK ybiS ycfS ynhG family protein
CP976_RS30080	COG1376	ErfK ybiS ycfS ynhG family protein
CP976_RS30120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP976_RS30125	COG3409	Peptidoglycan-binding domain 1 protein
CP976_RS30125	COG3757	hydrolase, family 25
CP976_RS30135	COG1401	restriction endodeoxyribonuclease activity
CP976_RS30145	COG1760	l-serine dehydratase
CP976_RS30150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP976_RS30155	COG0509	glycine decarboxylation via glycine cleavage system
CP976_RS30160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP976_RS30180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP976_RS30195	COG0444	Belongs to the ABC transporter superfamily
CP976_RS30200	COG4608	Belongs to the ABC transporter superfamily
CP976_RS30205	COG2860	membrane
CP976_RS30225	COG2378	regulation of single-species biofilm formation
CP976_RS30230	COG1309	transcriptional regulator
CP976_RS30255	COG0482	sulfurtransferase activity
CP976_RS30275	COG1611	Belongs to the LOG family
CP976_RS30280	COG4221	oxidoreductase activity
CP976_RS30290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP976_RS30310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP976_RS30315	COG0154	amidase activity
CP976_RS30325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP976_RS30330	COG2226	methyltransferase
CP976_RS30340	COG2409	Drug exporters of the RND superfamily
CP976_RS30345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP976_RS30360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP976_RS30360	COG1672	PFAM Archaeal ATPase
CP976_RS30370	COG2133	pyrroloquinoline quinone binding
CP976_RS30375	COG0667	Aldo Keto reductase
CP976_RS30385	COG5001	Diguanylate cyclase
CP976_RS30400	COG0440	acetolactate synthase activity
CP976_RS30405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP976_RS30410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP976_RS30415	COG0477	Major facilitator Superfamily
CP976_RS30425	COG4608	Belongs to the ABC transporter superfamily
CP976_RS30435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP976_RS30440	COG0747	negative chemotaxis
CP976_RS30450	COG3835	regulator
CP976_RS30455	COG0506	proline dehydrogenase activity
CP976_RS30460	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS30480	COG0473	3-isopropylmalate dehydrogenase activity
CP976_RS30485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP976_RS30510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP976_RS30545	COG2353	YceI-like domain
CP976_RS30550	COG0438	transferase activity, transferring glycosyl groups
CP976_RS30555	COG0697	spore germination
CP976_RS30560	COG0300	oxidoreductase activity
CP976_RS30570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP976_RS30590	COG2018	Roadblock/LC7 domain
CP976_RS30610	COG2018	Roadblock/LC7 domain
CP976_RS30615	COG5002	protein histidine kinase activity
CP976_RS30625	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP976_RS30630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP976_RS30685	COG1414	Transcriptional regulator
CP976_RS30690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP976_RS30695	COG0066	3-isopropylmalate dehydratase activity
CP976_RS30705	COG0776	regulation of translation
CP976_RS30715	COG1920	GTP binding
CP976_RS30725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP976_RS30730	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP976_RS30750	COG0351	phosphomethylpyrimidine kinase
CP976_RS30755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP976_RS30770	COG0326	Molecular chaperone. Has ATPase activity
CP976_RS30780	COG0742	ribosomal rna small subunit methyltransferase
CP976_RS30785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP976_RS30800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP976_RS30805	COG0571	ribonuclease III activity
CP976_RS30810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP976_RS30815	COG1733	regulation of RNA biosynthetic process
CP976_RS30820	COG2340	Cysteine-rich secretory protein family
CP976_RS30825	COG1254	Belongs to the acylphosphatase family
CP976_RS30835	COG1196	nuclear chromosome segregation
CP976_RS30840	COG0477	Major facilitator Superfamily
CP976_RS30880	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP976_RS30900	COG0442	prolyl-tRNA aminoacylation
CP976_RS30910	COG0228	four-way junction DNA binding
CP976_RS30915	COG1837	Belongs to the UPF0109 family
CP976_RS30920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP976_RS30925	COG0336	Belongs to the RNA methyltransferase TrmD family
CP976_RS30930	COG0335	large ribosomal subunit rRNA binding
CP976_RS30950	COG0681	Belongs to the peptidase S26 family
CP976_RS30965	COG0792	nuclease activity
CP976_RS30980	COG1191	sigma factor activity
CP976_RS30990	COG4942	peptidase
CP976_RS30995	COG0052	Belongs to the universal ribosomal protein uS2 family
CP976_RS31000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP976_RS31005	COG0528	UMP kinase activity
CP976_RS31010	COG0233	cytoplasmic translational termination
CP976_RS31025	COG2226	methyltransferase
CP976_RS31075	COG1302	Protein conserved in bacteria
CP976_RS31085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP976_RS31095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CP976_RS31100	COG3842	ATPase activity
CP976_RS31130	COG1136	(ABC) transporter
CP976_RS31135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP976_RS31145	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS31160	COG0584	glycerophosphoryl diester phosphodiesterase
CP976_RS31165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP976_RS31195	COG3842	ATPase activity
CP976_RS31200	COG1176	ABC-type spermidine putrescine transport system, permease component I
CP976_RS31205	COG1177	transmembrane transport
CP976_RS31210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS31230	COG1733	regulation of RNA biosynthetic process
CP976_RS31260	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS31275	COG1653	transport
CP976_RS31280	COG4209	transmembrane transport
CP976_RS31285	COG0395	ABC-type sugar transport system, permease component
CP976_RS31330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP976_RS31335	COG0750	zinc metalloprotease
CP976_RS31340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP976_RS31355	COG0442	prolyl-tRNA aminoacylation
CP976_RS31380	COG0779	Required for maturation of 30S ribosomal subunits
CP976_RS31395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP976_RS31405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP976_RS31410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP976_RS31440	COG0444	Belongs to the ABC transporter superfamily
CP976_RS31445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP976_RS31450	COG0601	transmembrane transport
CP976_RS31455	COG0747	negative chemotaxis
CP976_RS31460	COG0455	bacterial-type flagellum organization
CP976_RS31470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP976_RS31475	COG1185	polyribonucleotide nucleotidyltransferase activity
CP976_RS31480	COG0612	Peptidase, M16
CP976_RS31485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP976_RS31505	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CP976_RS31510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS31515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP976_RS31550	COG2770	Histidine kinase
CP976_RS31550	COG2208	phosphoserine phosphatase activity
CP976_RS31560	COG4999	Histidine kinase
CP976_RS31560	COG2205	protein histidine kinase activity
CP976_RS31560	COG3850	Histidine kinase
CP976_RS31560	COG3437	response regulator, receiver
CP976_RS31570	COG1674	ftsk spoiiie
CP976_RS31580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP976_RS31590	COG1058	Belongs to the CinA family
CP976_RS31590	COG1546	Belongs to the CinA family
CP976_RS31595	COG1396	sequence-specific DNA binding
CP976_RS31600	COG0783	Belongs to the Dps family
CP976_RS31610	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS31615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP976_RS31620	COG1201	RNA secondary structure unwinding
CP976_RS31650	COG0628	permease
CP976_RS31655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CP976_RS31665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP976_RS31680	COG0765	amino acid transport
CP976_RS31685	COG0765	amino acid transport
CP976_RS31690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS31695	COG1126	abc transporter atp-binding protein
CP976_RS31700	COG0745	RESPONSE REGULATOR receiver
CP976_RS31705	COG2205	protein histidine kinase activity
CP976_RS31710	COG2358	TRAP transporter, solute receptor (TAXI family
CP976_RS31735	COG2197	response regulator
CP976_RS31740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP976_RS31760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP976_RS31770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP976_RS31775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP976_RS31785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP976_RS31820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP976_RS31825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP976_RS31830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP976_RS31845	COG0588	phosphoglycerate mutase activity
CP976_RS31870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP976_RS31905	COG1131	(ABC) transporter
CP976_RS31910	COG2186	Transcriptional regulator
CP976_RS31915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP976_RS31930	COG0187	DNA topoisomerase II activity
CP976_RS31940	COG4585	Histidine kinase
CP976_RS31945	COG2197	response regulator
CP976_RS31955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS31960	COG4565	transcriptional regulatory protein
CP976_RS31965	COG3290	protein histidine kinase activity
CP976_RS31980	COG0372	Belongs to the citrate synthase family
CP976_RS32000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP976_RS32005	COG0612	Peptidase, M16
CP976_RS32020	COG1802	Transcriptional regulator
CP976_RS32025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP976_RS32050	COG1435	thymidine kinase activity
CP976_RS32080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP976_RS32090	COG0745	RESPONSE REGULATOR receiver
CP976_RS32095	COG2205	protein histidine kinase activity
CP976_RS32120	COG0756	dUTP diphosphatase activity
CP976_RS32160	COG0569	domain protein
CP976_RS32165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS32170	COG0531	amino acid
CP976_RS32175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP976_RS32190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP976_RS32200	COG3629	intracellular signal transduction
CP976_RS32230	COG2814	Major facilitator Superfamily
CP976_RS32240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CP976_RS32245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP976_RS32250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP976_RS32255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS32260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP976_RS32285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP976_RS32295	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS32330	COG0477	Major facilitator Superfamily
CP976_RS32365	COG1309	transcriptional regulator
CP976_RS32385	COG0667	Aldo Keto reductase
CP976_RS32395	COG0667	Aldo Keto reductase
CP976_RS32400	COG2814	Major facilitator Superfamily
CP976_RS32405	COG0667	Aldo Keto reductase
CP976_RS32450	COG0655	NAD(P)H dehydrogenase (quinone) activity
CP976_RS32455	COG1073	alpha beta
CP976_RS32515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP976_RS32560	COG3594	Acyltransferase
CP976_RS32605	COG0243	molybdopterin cofactor binding
CP976_RS32610	COG1799	cell septum assembly
CP976_RS32615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP976_RS32645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP976_RS32655	COG2255	four-way junction helicase activity
CP976_RS32685	COG2235	arginine
CP976_RS32690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP976_RS32700	COG1024	Enoyl-CoA hydratase
CP976_RS32755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP976_RS32760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP976_RS32765	COG0019	diaminopimelate decarboxylase activity
CP976_RS32770	COG2197	response regulator
CP976_RS32810	COG2815	serine threonine protein kinase
CP976_RS32810	COG0515	serine threonine protein kinase
CP976_RS32825	COG0702	epimerase
CP976_RS32830	COG3631	Ketosteroid isomerase-related protein
CP976_RS32850	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS32855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP976_RS32890	COG0604	alcohol dehydrogenase
CP976_RS32890	COG3321	synthase
CP976_RS32895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP976_RS32900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP976_RS32990	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CP976_RS33025	COG2197	response regulator
CP976_RS33040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP976_RS33050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP976_RS33060	COG4214	carbohydrate transport
CP976_RS33070	COG4213	ABC transporter substrate-binding protein
CP976_RS33095	COG3458	cephalosporin-C deacetylase activity
CP976_RS33100	COG4209	transmembrane transport
CP976_RS33105	COG0395	ABC-type sugar transport system, permease component
CP976_RS33140	COG1653	transport
CP976_RS33145	COG1175	transmembrane transport
CP976_RS33150	COG0395	ABC-type sugar transport system, permease component
CP976_RS33155	COG1940	carbohydrate kinase activity
CP976_RS33160	COG4213	ABC transporter substrate-binding protein
CP976_RS33170	COG4214	carbohydrate transport
CP976_RS33175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP976_RS33180	COG0531	amino acid
CP976_RS33215	COG4733	cellulase activity
CP976_RS33215	COG4447	cellulose binding
CP976_RS33220	COG1024	Enoyl-CoA hydratase
CP976_RS33220	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS33225	COG0183	Belongs to the thiolase family
CP976_RS33230	COG1609	Transcriptional regulator
CP976_RS33235	COG3250	beta-galactosidase activity
CP976_RS33245	COG1175	transmembrane transport
CP976_RS33250	COG3833	ABC-type maltose transport systems, permease component
CP976_RS33255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP976_RS33260	COG2197	response regulator
CP976_RS33270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP976_RS33285	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP976_RS33295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP976_RS33300	COG3253	May function as heme-dependent peroxidase
CP976_RS33320	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS33335	COG3220	belongs to the UPF0276 family
CP976_RS33340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP976_RS33375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS33375	COG0723	plastoquinol--plastocyanin reductase activity
CP976_RS33390	COG2326	polyphosphate kinase activity
CP976_RS33400	COG0330	HflC and HflK could
CP976_RS33435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP976_RS33440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP976_RS33450	COG1472	Belongs to the glycosyl hydrolase 3 family
CP976_RS33475	COG0395	ABC-type sugar transport system, permease component
CP976_RS33480	COG1175	transmembrane transport
CP976_RS33500	COG1737	Transcriptional regulator
CP976_RS33505	COG4821	SIS domain
CP976_RS33510	COG1609	Transcriptional regulator
CP976_RS33520	COG1175	transmembrane transport
CP976_RS33525	COG0395	ABC-type sugar transport system, permease component
CP976_RS33530	COG1874	Beta-galactosidase
CP976_RS33560	COG0745	RESPONSE REGULATOR receiver
CP976_RS33565	COG2205	protein histidine kinase activity
CP976_RS33575	COG1174	glycine betaine transport
CP976_RS33650	COG1404	Belongs to the peptidase S8 family
CP976_RS33655	COG1309	transcriptional regulator
CP976_RS33675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP976_RS33740	COG0583	DNA-binding transcription factor activity
CP976_RS33750	COG1175	transmembrane transport
CP976_RS33765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP976_RS33785	COG2409	Drug exporters of the RND superfamily
CP976_RS33840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS33845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CP976_RS33870	COG0529	Catalyzes the synthesis of activated sulfate
CP976_RS33875	COG0175	sulfate reduction
CP976_RS33905	COG1960	acyl-CoA dehydrogenase activity
CP976_RS33945	COG1609	Transcriptional regulator
CP976_RS33955	COG0395	ABC-type sugar transport system, permease component
CP976_RS33960	COG1175	transmembrane transport
CP976_RS34010	COG1175	transmembrane transport
CP976_RS34015	COG0395	ABC-type sugar transport system, permease component
CP976_RS34070	COG0583	DNA-binding transcription factor activity
CP976_RS34075	COG1609	Transcriptional regulator
CP976_RS34090	COG2040	homocysteine
CP976_RS34095	COG0531	amino acid
CP976_RS34150	COG2755	lipolytic protein G-D-S-L family
CP976_RS34170	COG1309	transcriptional regulator
CP976_RS34210	COG1131	(ABC) transporter
CP976_RS34220	COG0395	ABC-type sugar transport system, permease component
CP976_RS34225	COG1175	transmembrane transport
CP976_RS34250	COG0277	FAD linked oxidase domain protein
CP976_RS34255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP976_RS34275	COG1162	GTPase activity
CP976_RS34285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP976_RS34300	COG0028	Belongs to the TPP enzyme family
CP976_RS34330	COG1802	Transcriptional regulator
CP976_RS34340	COG3835	regulator
CP976_RS34360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS34365	COG2252	PERMEase
CP976_RS34370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CP976_RS34370	COG3608	succinylglutamate desuccinylase aspartoacylase
CP976_RS34390	COG0726	polysaccharide deacetylase
CP976_RS34395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP976_RS34400	COG2192	nodulation
CP976_RS34410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CP976_RS34415	COG0859	PFAM glycosyl transferase family 9
CP976_RS34425	COG0438	transferase activity, transferring glycosyl groups
CP976_RS34430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CP976_RS34435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CP976_RS34435	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CP976_RS34480	COG1609	Transcriptional regulator
CP976_RS34485	COG1653	transport
CP976_RS34500	COG0366	Alpha amylase catalytic
CP976_RS34515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CP976_RS34520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CP976_RS34540	COG0137	argininosuccinate synthase activity
CP976_RS34585	COG2197	response regulator
CP976_RS34590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP976_RS34595	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS34630	COG3960	tartronate-semialdehyde synthase activity
CP976_RS34645	COG0753	catalase activity
CP976_RS34650	COG2084	Dehydrogenase
CP976_RS34655	COG3622	Belongs to the hyi family
CP976_RS34680	COG2351	hydroxyisourate hydrolase activity
CP976_RS34695	COG2233	PERMEase
CP976_RS34715	COG0436	Aminotransferase
CP976_RS34720	COG1733	regulation of RNA biosynthetic process
CP976_RS34725	COG4264	IucA IucC family
CP976_RS34750	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CP976_RS34770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP976_RS34780	COG2045	Belongs to the ComB family
CP976_RS34790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP976_RS34810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP976_RS34830	COG0583	DNA-binding transcription factor activity
CP976_RS34835	COG1414	Transcriptional regulator
CP976_RS34840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP976_RS34845	COG4266	Belongs to the allantoicase family
CP976_RS34850	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS34880	COG2197	response regulator
CP976_RS34885	COG0673	inositol 2-dehydrogenase activity
CP976_RS34890	COG2188	Transcriptional regulator
CP976_RS34895	COG1940	carbohydrate kinase activity
CP976_RS34905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP976_RS34970	COG0657	acetylesterase activity
CP976_RS35000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS35005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP976_RS35025	COG1126	abc transporter atp-binding protein
CP976_RS35040	COG0405	Gamma-glutamyltransferase
CP976_RS35045	COG0542	response to heat
CP976_RS35070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP976_RS35085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP976_RS35095	COG1953	Uracil, thiamine, allantoin
CP976_RS35120	COG0483	inositol monophosphate 1-phosphatase activity
CP976_RS35135	COG1609	Transcriptional regulator
CP976_RS35165	COG0488	(ABC) transporter
CP976_RS35185	COG0640	Transcriptional regulator
CP976_RS35205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP976_RS35220	COG1929	Belongs to the glycerate kinase type-1 family
CP976_RS35235	COG0688	phosphatidylethanolamine metabolic process
CP976_RS35240	COG1960	acyl-CoA dehydrogenase activity
CP976_RS35255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS35255	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP976_RS35260	COG0604	alcohol dehydrogenase
CP976_RS35270	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS35330	COG3835	regulator
CP976_RS35335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP976_RS35340	COG0765	amino acid transport
CP976_RS35345	COG1126	abc transporter atp-binding protein
CP976_RS35350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS35355	COG2755	lipolytic protein G-D-S-L family
CP976_RS35360	COG2362	D-Aminopeptidase
CP976_RS35365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP976_RS35375	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP976_RS35400	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS35405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS35420	COG1793	dna ligase
CP976_RS35420	COG3285	dna ligase
CP976_RS35480	COG2226	methyltransferase
CP976_RS35485	COG1597	lipid kinase activity
CP976_RS35495	COG0488	(ABC) transporter
CP976_RS35525	COG0517	IMP dehydrogenase activity
CP976_RS35525	COG0516	GMP reductase activity
CP976_RS35545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP976_RS35650	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS35655	COG1309	transcriptional regulator
CP976_RS35690	COG0702	epimerase
CP976_RS35715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP976_RS35735	COG0300	oxidoreductase activity
CP976_RS35780	COG2080	2 iron, 2 sulfur cluster binding
CP976_RS35785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP976_RS35790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS35805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP976_RS35810	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS35835	COG1063	alcohol dehydrogenase
CP976_RS35850	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS35875	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS35895	COG0210	DNA helicase
CP976_RS35920	COG0028	Belongs to the TPP enzyme family
CP976_RS35985	COG0443	Heat shock 70 kDa protein
CP976_RS36010	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP976_RS36015	COG4106	trans-aconitate 2-methyltransferase activity
CP976_RS36015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP976_RS36030	COG2378	regulation of single-species biofilm formation
CP976_RS36035	COG3401	FG-GAP repeat protein
CP976_RS36045	COG4733	cellulase activity
CP976_RS36045	COG5297	Belongs to the glycosyl hydrolase family 6
CP976_RS36050	COG5297	Belongs to the glycosyl hydrolase family 6
CP976_RS36060	COG0656	L-ascorbic acid biosynthetic process
CP976_RS36100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP976_RS36110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP976_RS36115	COG3383	formate dehydrogenase (NAD+) activity
CP976_RS36120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP976_RS36130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP976_RS36145	COG1940	carbohydrate kinase activity
CP976_RS36150	COG1129	ABC transporter
CP976_RS36155	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP976_RS36185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP976_RS36220	COG2223	nitrite transmembrane transporter activity
CP976_RS36230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP976_RS36240	COG0045	succinate-CoA ligase (ADP-forming) activity
CP976_RS36250	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS36265	COG3284	Transcriptional regulator
CP976_RS36275	COG3485	protocatechuate 3,4-dioxygenase
CP976_RS36285	COG0702	epimerase
CP976_RS36290	COG2353	YceI-like domain
CP976_RS36295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP976_RS36325	COG0747	negative chemotaxis
CP976_RS36330	COG0251	oxidation-reduction process
CP976_RS36335	COG1733	regulation of RNA biosynthetic process
CP976_RS36355	COG0297	glycogen (starch) synthase activity
CP976_RS36375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP976_RS36390	COG0346	lactoylglutathione lyase activity
CP976_RS36395	COG0477	Major facilitator Superfamily
CP976_RS36405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP976_RS36410	COG1082	Xylose isomerase domain protein TIM barrel
CP976_RS36410	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP976_RS36420	COG0406	alpha-ribazole phosphatase activity
CP976_RS36425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP976_RS36430	COG0166	Belongs to the GPI family
CP976_RS36445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP976_RS36525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP976_RS36530	COG3250	beta-galactosidase activity
CP976_RS36535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CP976_RS36555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS36565	COG1486	melibiose metabolic process
CP976_RS36590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP976_RS36620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS36635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP976_RS36640	COG3938	Belongs to the proline racemase family
CP976_RS36655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS36660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP976_RS36670	COG1414	Transcriptional regulator
CP976_RS36705	COG0477	Major facilitator Superfamily
CP976_RS36710	COG3511	phospholipase C
CP976_RS36740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CP976_RS36745	COG0477	Major facilitator Superfamily
CP976_RS36760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS36765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP976_RS36770	COG3485	protocatechuate 3,4-dioxygenase
CP976_RS36775	COG3485	protocatechuate 3,4-dioxygenase
CP976_RS36795	COG1846	Transcriptional regulator
CP976_RS36815	COG1793	dna ligase
CP976_RS36860	COG1834	amidinotransferase
CP976_RS36870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP976_RS36875	COG0488	(ABC) transporter
CP976_RS36900	COG1515	deoxyribonuclease V activity
CP976_RS36910	COG3268	Saccharopine dehydrogenase
CP976_RS36920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP976_RS36925	COG0183	Belongs to the thiolase family
CP976_RS36930	COG1024	Enoyl-CoA hydratase
CP976_RS36930	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP976_RS36940	COG1113	amino acid transport
CP976_RS36950	COG0010	Belongs to the arginase family
CP976_RS36960	COG2936	dipeptidyl-peptidase activity
CP976_RS36970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP976_RS36985	COG0488	(ABC) transporter
CP976_RS36995	COG2183	response to ionizing radiation
CP976_RS37025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP976_RS37070	COG1134	teichoic acid transport
CP976_RS37075	COG1562	ergosterol biosynthetic process
CP976_RS37085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP976_RS37095	COG1657	PFAM Prenyltransferase squalene oxidase
CP976_RS37110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP976_RS37115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP976_RS37135	COG2365	Tyrosine phosphatase family
CP976_RS37155	COG2755	lipolytic protein G-D-S-L family
CP976_RS37160	COG2226	methyltransferase
CP976_RS37210	COG1063	alcohol dehydrogenase
CP976_RS37215	COG0156	8-amino-7-oxononanoate synthase activity
CP976_RS37220	COG0583	DNA-binding transcription factor activity
CP976_RS37240	COG3958	Transketolase
CP976_RS37245	COG3959	Transketolase, thiamine diphosphate binding domain
CP976_RS37270	COG0174	glutamine synthetase
CP976_RS37285	COG2197	response regulator
CP976_RS37300	COG0006	proline dipeptidase activity
CP976_RS37305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CP976_RS37310	COG0022	dehydrogenase e1 component
CP976_RS37315	COG0402	S-adenosylhomocysteine deaminase activity
CP976_RS37350	COG0183	Belongs to the thiolase family
CP976_RS37360	COG1011	Hydrolase
CP976_RS37385	COG0494	nUDIX hydrolase
CP976_RS37400	COG2188	Transcriptional regulator
CP976_RS37410	COG3962	Belongs to the TPP enzyme family
CP976_RS37415	COG3718	enzyme involved in inositol metabolism
CP976_RS37425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP976_RS37450	COG0673	inositol 2-dehydrogenase activity
CP976_RS37460	COG0673	inositol 2-dehydrogenase activity
CP976_RS37480	COG3548	integral membrane protein
CP976_RS37485	COG0673	inositol 2-dehydrogenase activity
CP976_RS37490	COG1609	Transcriptional regulator
CP976_RS37500	COG2234	aminopeptidase activity
CP976_RS37520	COG1132	(ABC) transporter
CP976_RS37525	COG1132	(ABC) transporter
CP976_RS37525	COG2375	cellular response to nickel ion
CP976_RS37545	COG2197	response regulator
CP976_RS37575	COG2838	Isocitrate dehydrogenase
CP976_RS37580	COG0668	transmembrane transport
CP976_RS37590	COG1132	(ABC) transporter
CP976_RS37605	COG3290	protein histidine kinase activity
CP976_RS37610	COG4565	transcriptional regulatory protein
CP976_RS37625	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP976_RS37630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP976_RS37635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP976_RS37640	COG1120	ATPase activity
CP976_RS37645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CP976_RS37650	COG1132	(ABC) transporter
CP976_RS37660	COG1132	(ABC) transporter
CP976_RS37675	COG2382	esterase
CP976_RS37695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP976_RS37700	COG1535	isochorismatase
CP976_RS37700	COG3433	isochorismatase activity
CP976_RS37705	COG0251	oxidation-reduction process
CP976_RS37715	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS37720	COG2186	Transcriptional regulator
CP976_RS37735	COG1621	beta-fructofuranosidase activity
CP976_RS37740	COG1609	Transcriptional regulator
CP976_RS37750	COG1175	transmembrane transport
CP976_RS37755	COG0395	ABC-type sugar transport system, permease component
CP976_RS37765	COG1621	beta-fructofuranosidase activity
CP976_RS37775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP976_RS37790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP976_RS37810	COG0297	glycogen (starch) synthase activity
CP976_RS37815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP976_RS37840	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS37865	COG0154	amidase activity
CP976_RS37875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP976_RS37880	COG2186	Transcriptional regulator
CP976_RS37885	COG1879	ABC-type sugar transport system periplasmic component
CP976_RS37890	COG1129	ABC transporter
CP976_RS37900	COG4948	Mandelate Racemase Muconate Lactonizing
CP976_RS37905	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS37920	COG3618	amidohydrolase
CP976_RS37940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP976_RS37960	COG2208	phosphoserine phosphatase activity
CP976_RS37960	COG2770	Histidine kinase
CP976_RS37985	COG0531	amino acid
CP976_RS38000	COG0726	polysaccharide deacetylase
CP976_RS38050	COG0583	DNA-binding transcription factor activity
CP976_RS38060	COG1053	succinate dehydrogenase
CP976_RS38065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP976_RS38085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS38095	COG0523	cobalamin synthesis protein
CP976_RS38105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP976_RS38130	COG3360	Dodecin
CP976_RS38135	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP976_RS38140	COG0121	glutamine amidotransferase
CP976_RS38145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP976_RS38220	COG0640	Transcriptional regulator
CP976_RS38235	COG0523	cobalamin synthesis protein
CP976_RS38260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP976_RS38280	COG0640	Transcriptional regulator
CP976_RS38355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS38355	COG3320	Male sterility
CP976_RS38360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS38360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS38360	COG4221	oxidoreductase activity
CP976_RS38360	COG3321	synthase
CP976_RS38360	COG4221	oxidoreductase activity
CP976_RS38360	COG0300	oxidoreductase activity
CP976_RS38360	COG0300	oxidoreductase activity
CP976_RS38360	COG3321	synthase
CP976_RS38360	COG3321	synthase
CP976_RS38360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS38360	COG0300	oxidoreductase activity
CP976_RS38360	COG4221	oxidoreductase activity
CP976_RS38370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP976_RS38370	COG4221	oxidoreductase activity
CP976_RS38370	COG0300	oxidoreductase activity
CP976_RS38370	COG3321	synthase
CP976_RS38380	COG2124	cytochrome p450
CP976_RS38395	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS38395	COG3321	synthase
CP976_RS38395	COG4221	oxidoreductase activity
CP976_RS38395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP976_RS38400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP976_RS38415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP976_RS38415	COG3321	synthase
CP976_RS38415	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS38415	COG0300	oxidoreductase activity
CP976_RS38415	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS38420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CP976_RS38420	COG2070	2-Nitropropane dioxygenase
CP976_RS38430	COG1902	pentaerythritol trinitrate reductase activity
CP976_RS38450	COG1177	transmembrane transport
CP976_RS38460	COG3842	ATPase activity
CP976_RS38475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP976_RS38485	COG1169	isochorismate synthase
CP976_RS38530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP976_RS38550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP976_RS38555	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS38560	COG0596	Alpha beta hydrolase
CP976_RS38565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP976_RS38575	COG1132	(ABC) transporter
CP976_RS38605	COG1122	ATPase activity
CP976_RS38615	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CP976_RS38620	COG0310	cobalt ion transport
CP976_RS38625	COG2815	serine threonine protein kinase
CP976_RS38625	COG0515	serine threonine protein kinase
CP976_RS38635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP976_RS38640	COG0456	acetyltransferase
CP976_RS38655	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS38675	COG0019	diaminopimelate decarboxylase activity
CP976_RS38690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP976_RS38700	COG0596	Alpha beta hydrolase
CP976_RS38720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP976_RS38750	COG0542	response to heat
CP976_RS38760	COG0577	efflux transmembrane transporter activity
CP976_RS38760	COG1136	(ABC) transporter
CP976_RS38765	COG1556	Lactate utilization protein
CP976_RS38770	COG1139	Iron-sulfur cluster binding protein
CP976_RS38775	COG0247	lactate metabolic process
CP976_RS38780	COG1070	Carbohydrate kinase
CP976_RS38785	COG3347	Dehydrogenase
CP976_RS38785	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS38795	COG1129	ABC transporter
CP976_RS38800	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP976_RS38810	COG1879	ABC-type sugar transport system periplasmic component
CP976_RS38825	COG1609	Transcriptional regulator
CP976_RS38840	COG1595	DNA-templated transcription, initiation
CP976_RS38845	COG1357	PFAM Pentapeptide repeats (8 copies)
CP976_RS38855	COG1309	transcriptional regulator
CP976_RS38865	COG2706	6-phosphogluconolactonase activity
CP976_RS38890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CP976_RS38890	COG2124	cytochrome p450
CP976_RS38920	COG1796	DNA polymerase
CP976_RS38920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CP976_RS38925	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS38955	COG1012	belongs to the aldehyde dehydrogenase family
CP976_RS39000	COG2124	cytochrome p450
CP976_RS39020	COG0435	Glutathione S-transferase
CP976_RS39045	COG2124	cytochrome p450
CP976_RS39070	COG0667	Aldo Keto reductase
CP976_RS39100	COG3250	beta-galactosidase activity
CP976_RS39110	COG2267	carboxylic ester hydrolase activity
CP976_RS39115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP976_RS39170	COG2890	protein-(glutamine-N5) methyltransferase activity
CP976_RS39185	COG0248	Ppx GppA phosphatase
CP976_RS39190	COG2274	protein secretion by the type I secretion system
CP976_RS39220	COG2197	response regulator
CP976_RS39230	COG1132	(ABC) transporter
CP976_RS39240	COG0515	serine threonine protein kinase
CP976_RS39250	COG0517	IMP dehydrogenase activity
CP976_RS39295	COG2226	methyltransferase
CP976_RS39300	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CP976_RS39330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP976_RS39340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP976_RS39360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP976_RS39370	COG1132	(ABC) transporter
CP976_RS39405	COG2182	Extracellular solute-binding protein
CP976_RS39410	COG0395	ABC-type sugar transport system, permease component
CP976_RS39415	COG1175	transmembrane transport
CP976_RS39420	COG1846	Transcriptional regulator
CP976_RS39420	COG1940	carbohydrate kinase activity
CP976_RS39450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CP976_RS39460	COG0673	inositol 2-dehydrogenase activity
CP976_RS39520	COG1940	carbohydrate kinase activity
CP976_RS39535	COG0395	ABC-type sugar transport system, permease component
CP976_RS39565	COG1072	(Pantothenic acid kinase))
CP976_RS39585	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP976_RS39590	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CP976_RS39620	COG0673	inositol 2-dehydrogenase activity
CP976_RS39635	COG3973	AAA domain
CP976_RS39640	COG1082	Xylose isomerase domain protein TIM barrel
CP976_RS39645	COG0673	inositol 2-dehydrogenase activity
CP976_RS39650	COG2814	Major facilitator Superfamily
CP976_RS39660	COG1609	Transcriptional regulator
CP976_RS39670	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CP976_RS39675	COG0667	Aldo Keto reductase
CP976_RS39705	COG3321	synthase
CP976_RS39705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP976_RS39710	COG0318	PFAM AMP-dependent synthetase and ligase
CP976_RS39715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP976_RS39720	COG0667	Aldo Keto reductase
CP976_RS39765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP976_RS39770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP976_RS39775	COG2080	2 iron, 2 sulfur cluster binding
CP976_RS39790	COG1295	ribonuclease BN
CP976_RS39825	COG0477	Major facilitator Superfamily
CP976_RS39875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CP976_RS39880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CP976_RS39885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CP976_RS39915	COG0596	Alpha beta hydrolase
CP976_RS39930	COG3290	protein histidine kinase activity
CP976_RS39960	COG0243	molybdopterin cofactor binding
CP976_RS39975	COG4608	Belongs to the ABC transporter superfamily
CP976_RS39990	COG0747	negative chemotaxis
CP976_RS40010	COG2851	Citrate transporter
CP976_RS40015	COG0583	DNA-binding transcription factor activity
CP976_RS40020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP976_RS40025	COG2301	Belongs to the HpcH HpaI aldolase family
CP976_RS40035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CP976_RS40055	COG0438	transferase activity, transferring glycosyl groups
CP976_RS40065	COG2353	YceI-like domain
CP976_RS40085	COG3739	integral membrane protein
CP976_RS40120	COG2267	carboxylic ester hydrolase activity
CP976_RS40125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CP976_RS40145	COG0326	Molecular chaperone. Has ATPase activity
CP976_RS40155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP976_RS40170	COG0726	polysaccharide deacetylase
CP976_RS40175	COG4249	Peptidase C14 caspase catalytic subunit p20
CP976_RS40175	COG2319	Wd-40 repeat
CP976_RS40185	COG2304	oxidoreductase activity
CP976_RS40200	COG0667	Aldo Keto reductase
CP976_RS40225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS40235	COG0515	serine threonine protein kinase
CP976_RS40265	COG2340	Cysteine-rich secretory protein family
CP976_RS40275	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP976_RS40275	COG1672	PFAM Archaeal ATPase
CP976_RS40290	COG3852	Histidine kinase
CP976_RS40315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP976_RS40335	COG3189	MarR family transcriptional regulator
CP976_RS40380	COG1982	Orn Lys Arg decarboxylase major
CP976_RS40425	COG1252	NADH dehydrogenase
CP976_RS40445	COG2172	sigma factor antagonist activity
CP976_RS40450	COG1366	Belongs to the anti-sigma-factor antagonist family
CP976_RS40455	COG1366	Belongs to the anti-sigma-factor antagonist family
CP976_RS40485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP976_RS40490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP976_RS40495	COG3281	Trehalose synthase
CP976_RS40505	COG0366	Alpha amylase catalytic
CP976_RS40560	COG0181	hydroxymethylbilane synthase activity
CP976_RS40575	COG3285	dna ligase
CP976_RS40575	COG1793	dna ligase
CP976_RS40585	COG2223	nitrite transmembrane transporter activity
CP976_RS40590	COG2207	Transcriptional regulator
CP976_RS40625	COG1609	Transcriptional regulator
CP976_RS40630	COG1621	beta-fructofuranosidase activity
CP976_RS40635	COG0395	ABC-type sugar transport system, permease component
CP976_RS40640	COG1175	transmembrane transport
CP976_RS40650	COG1621	beta-fructofuranosidase activity
CP976_RS40680	COG0009	L-threonylcarbamoyladenylate synthase
CP976_RS40690	COG2124	cytochrome p450
CP976_RS40735	COG0753	catalase activity
CP976_RS40765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP976_RS40770	COG2192	nodulation
CP976_RS40780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CP976_RS40795	COG0438	transferase activity, transferring glycosyl groups
CP976_RS40800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CP976_RS40805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CP976_RS40805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CP976_RS40830	COG1982	Orn Lys Arg decarboxylase major
CP976_RS40865	COG3540	Alkaline phosphatase
CP976_RS40900	COG1295	ribonuclease BN
CP976_RS40910	COG0456	acetyltransferase
CP976_RS40930	COG3397	chitin binding
CP976_RS40945	COG2409	Drug exporters of the RND superfamily
CP976_RS41000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS41015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS41020	COG4585	Histidine kinase
CP976_RS41025	COG2197	response regulator
CP976_RS41065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP976_RS41090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP976_RS41095	COG2124	cytochrome p450
CP976_RS41105	COG1819	glycosyl
CP976_RS41120	COG1175	transmembrane transport
CP976_RS41125	COG0395	ABC-type sugar transport system, permease component
CP976_RS41190	COG2508	Transcriptional regulator
CP976_RS41200	COG0411	ABC transporter
CP976_RS41205	COG0559	Belongs to the binding-protein-dependent transport system permease family
CP976_RS41235	COG5640	endopeptidase activity
CP976_RS41260	COG0142	geranyltranstransferase activity
CP976_RS41310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP976_RS41315	COG1063	alcohol dehydrogenase
CP976_RS41320	COG3265	gluconokinase activity
CP976_RS41330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP976_RS41345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP976_RS41365	COG1609	Transcriptional regulator
CP976_RS41375	COG1175	transmembrane transport
CP976_RS41380	COG0395	ABC-type sugar transport system, permease component
CP976_RS41390	COG0667	Aldo Keto reductase
CP976_RS41420	COG0477	Major facilitator Superfamily
CP976_RS41425	COG1278	Cold shock
CP976_RS41430	COG2814	Major facilitator Superfamily
CP976_RS41435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP976_RS41440	COG1063	alcohol dehydrogenase
CP976_RS41445	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP976_RS41460	COG1802	Transcriptional regulator
CP976_RS41500	COG0702	epimerase
CP976_RS41505	COG0483	inositol monophosphate 1-phosphatase activity
CP976_RS41550	COG1846	Transcriptional regulator
CP976_RS41580	COG1733	regulation of RNA biosynthetic process
CP976_RS41600	COG0657	acetylesterase activity
CP976_RS41620	COG0300	oxidoreductase activity
CP976_RS41640	COG1063	alcohol dehydrogenase
CP976_RS41645	COG0667	Aldo Keto reductase
CP976_RS41660	COG0789	Transcriptional regulator
CP976_RS41760	COG4249	Peptidase C14 caspase catalytic subunit p20
CP976_RS41760	COG2319	Wd-40 repeat
CP976_RS41780	COG1595	DNA-templated transcription, initiation
CP976_RS41810	COG0657	acetylesterase activity
CP976_RS41845	COG1695	Transcriptional regulator
CP976_RS41860	COG1028	Short-chain dehydrogenase reductase Sdr
CP976_RS41865	COG1959	2 iron, 2 sulfur cluster binding
CP976_RS41895	COG1595	DNA-templated transcription, initiation
CP976_RS42030	COG0583	DNA-binding transcription factor activity
CP976_RS42035	COG2329	Antibiotic biosynthesis monooxygenase
CP976_RS42095	COG1309	transcriptional regulator
CP976_RS42200	COG0154	amidase activity
CP976_RS42260	COG0492	ferredoxin-NADP+ reductase activity
CP976_RS42265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP976_RS42275	COG0640	Transcriptional regulator
CP976_RS42280	COG0798	PFAM Bile acid sodium symporter
CP976_RS42285	COG2072	flavoprotein involved in K transport
CP976_RS42360	COG2045	Belongs to the ComB family
CP976_RS42385	COG4221	oxidoreductase activity
CP976_RS42400	COG1309	transcriptional regulator
CP976_RS42440	COG1793	dna ligase
CP976_RS42465	COG2226	methyltransferase
CP976_RS42480	COG0583	DNA-binding transcription factor activity
CP976_RS42550	COG2124	cytochrome p450
CP976_RS42565	COG0604	alcohol dehydrogenase
CP976_RS42565	COG3321	synthase
CP976_RS42570	COG0657	acetylesterase activity
CP976_RS42605	COG1404	Belongs to the peptidase S8 family