locus-tag	class	description
B446_RS00160	COG0084	hydrolase, TatD family'
B446_RS00200	COG0667	Aldo Keto reductase
B446_RS00300	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B446_RS00300	COG1672	PFAM Archaeal ATPase
B446_RS00345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B446_RS00395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B446_RS00410	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B446_RS00425	COG0019	diaminopimelate decarboxylase activity
B446_RS00430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS00480	COG1595	DNA-templated transcription, initiation
B446_RS00505	COG0784	Response regulator, receiver
B446_RS00505	COG2198	Histidine kinase
B446_RS00505	COG5002	protein histidine kinase activity
B446_RS00515	COG2172	sigma factor antagonist activity
B446_RS00520	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS00525	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS00535	COG3103	Sh3 type 3 domain protein
B446_RS00535	COG1388	LysM domain
B446_RS00535	COG0791	NLP P60 protein
B446_RS00540	COG2124	cytochrome p450
B446_RS00595	COG1819	glycosyl
B446_RS00600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B446_RS00605	COG0477	Major facilitator Superfamily
B446_RS00630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B446_RS00645	COG0604	alcohol dehydrogenase
B446_RS00645	COG3321	synthase
B446_RS00685	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B446_RS00690	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS00715	COG2197	response regulator
B446_RS00740	COG1278	Cold shock
B446_RS00795	COG3209	COG3209 Rhs family protein
B446_RS00890	COG1181	Belongs to the D-alanine--D-alanine ligase family
B446_RS00895	COG2814	Major facilitator Superfamily
B446_RS00900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS00925	COG1509	lysine 2,3-aminomutase activity
B446_RS00930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B446_RS00945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS00995	COG1595	DNA-templated transcription, initiation
B446_RS01005	COG1595	DNA-templated transcription, initiation
B446_RS01040	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS01055	COG3665	Urea carboxylase-associated protein
B446_RS01065	COG1309	transcriptional regulator
B446_RS01085	COG2018	Roadblock/LC7 domain
B446_RS01105	COG1280	lysine exporter protein (LysE YggA)
B446_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS01155	COG0583	DNA-binding transcription factor activity
B446_RS01175	COG0596	Alpha beta hydrolase
B446_RS01190	COG3209	COG3209 Rhs family protein
B446_RS01210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B446_RS01230	COG1819	glycosyl
B446_RS01250	COG0726	polysaccharide deacetylase
B446_RS01265	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B446_RS01295	COG1902	pentaerythritol trinitrate reductase activity
B446_RS01300	COG5002	protein histidine kinase activity
B446_RS01310	COG1136	(ABC) transporter
B446_RS01315	COG1136	(ABC) transporter
B446_RS01325	COG0745	RESPONSE REGULATOR receiver
B446_RS01340	COG1063	alcohol dehydrogenase
B446_RS01345	COG1309	transcriptional regulator
B446_RS01420	COG4249	Peptidase C14 caspase catalytic subunit p20
B446_RS01420	COG2319	Wd-40 repeat
B446_RS01440	COG2268	Band 7 protein
B446_RS01460	COG3251	PFAM MbtH domain protein
B446_RS01505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B446_RS01530	COG0165	Argininosuccinate lyase
B446_RS01575	COG2124	cytochrome p450
B446_RS01585	COG0477	Major facilitator Superfamily
B446_RS01600	COG3321	synthase
B446_RS01600	COG0604	alcohol dehydrogenase
B446_RS01605	COG2226	methyltransferase
B446_RS01610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B446_RS01620	COG2070	2-Nitropropane dioxygenase
B446_RS01620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B446_RS01625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01635	COG0604	alcohol dehydrogenase
B446_RS01635	COG3321	synthase
B446_RS01640	COG0300	oxidoreductase activity
B446_RS01640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS01640	COG4221	oxidoreductase activity
B446_RS01640	COG3321	synthase
B446_RS01645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS01645	COG3321	synthase
B446_RS01645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS01645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS01650	COG0300	oxidoreductase activity
B446_RS01650	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS01650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS01650	COG3321	synthase
B446_RS01655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS01655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS01655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS01655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS01655	COG3321	synthase
B446_RS01655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS01655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS01655	COG3321	synthase
B446_RS01660	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS01660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS01660	COG3321	synthase
B446_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS01660	COG0300	oxidoreductase activity
B446_RS01670	COG2318	DinB family
B446_RS01695	COG1086	Polysaccharide biosynthesis protein
B446_RS01725	COG1733	regulation of RNA biosynthetic process
B446_RS01740	COG2175	clavaminate synthase activity
B446_RS01750	COG3246	L-lysine catabolic process to acetate
B446_RS01775	COG0572	uridine kinase
B446_RS01810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B446_RS01850	COG1247	-acetyltransferase
B446_RS01910	COG2211	Major facilitator Superfamily
B446_RS01965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B446_RS01990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS02080	COG0028	Belongs to the TPP enzyme family
B446_RS02085	COG0069	glutamate synthase activity
B446_RS02105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B446_RS02120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B446_RS02135	COG2272	Belongs to the type-B carboxylesterase lipase family
B446_RS02145	COG2197	response regulator
B446_RS02150	COG4585	Histidine kinase
B446_RS02155	COG0477	Major facilitator Superfamily
B446_RS02160	COG0456	acetyltransferase
B446_RS02175	COG0456	acetyltransferase
B446_RS02185	COG0477	Major facilitator Superfamily
B446_RS02290	COG0326	Molecular chaperone. Has ATPase activity
B446_RS02310	COG0583	DNA-binding transcription factor activity
B446_RS02335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B446_RS02345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B446_RS02360	COG1982	Orn Lys Arg decarboxylase major
B446_RS02365	COG1278	Cold shock
B446_RS02395	COG1349	DNA-binding transcription factor activity
B446_RS02415	COG4106	trans-aconitate 2-methyltransferase activity
B446_RS02430	COG1335	isochorismatase
B446_RS02455	COG1595	DNA-templated transcription, initiation
B446_RS02475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B446_RS02480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B446_RS02485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B446_RS02490	COG0254	rRNA binding
B446_RS02500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B446_RS02505	COG0701	Predicted permease
B446_RS02530	COG1846	Transcriptional regulator
B446_RS02530	COG1940	carbohydrate kinase activity
B446_RS02630	COG1131	(ABC) transporter
B446_RS02660	COG1881	PFAM PEBP family protein
B446_RS02670	COG2208	phosphoserine phosphatase activity
B446_RS02695	COG0142	geranyltranstransferase activity
B446_RS02705	COG2226	methyltransferase
B446_RS02715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B446_RS02745	COG2409	Drug exporters of the RND superfamily
B446_RS02750	COG1846	Transcriptional regulator
B446_RS02770	COG0477	Major facilitator Superfamily
B446_RS02780	COG2124	cytochrome p450
B446_RS02795	COG2267	carboxylic ester hydrolase activity
B446_RS02825	COG3250	beta-galactosidase activity
B446_RS02865	COG2258	MOSC domain
B446_RS02880	COG0254	rRNA binding
B446_RS02885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B446_RS02905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B446_RS02915	COG2409	Drug exporters of the RND superfamily
B446_RS02935	COG1609	Transcriptional regulator
B446_RS02940	COG1879	ABC-type sugar transport system periplasmic component
B446_RS02945	COG1129	ABC transporter
B446_RS02955	COG1172	Belongs to the binding-protein-dependent transport system permease family
B446_RS02975	COG1175	transmembrane transport
B446_RS03005	COG3537	Alpha-1,2-mannosidase
B446_RS03010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B446_RS03025	COG3842	ATPase activity
B446_RS03035	COG1176	ABC-type spermidine putrescine transport system, permease component I
B446_RS03040	COG1177	transmembrane transport
B446_RS03050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B446_RS03065	COG2755	lipolytic protein G-D-S-L family
B446_RS03070	COG1595	DNA-templated transcription, initiation
B446_RS03075	COG1090	epimerase
B446_RS03090	COG1309	transcriptional regulator
B446_RS03105	COG1960	acyl-CoA dehydrogenase activity
B446_RS03110	COG0045	succinate-CoA ligase (ADP-forming) activity
B446_RS03110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B446_RS03110	COG1042	CoA-binding domain protein
B446_RS03120	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B446_RS03140	COG1176	ABC-type spermidine putrescine transport system, permease component I
B446_RS03145	COG1177	transmembrane transport
B446_RS03150	COG3842	ATPase activity
B446_RS03160	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS03205	COG2755	lipolytic protein G-D-S-L family
B446_RS03220	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS03225	COG2508	Transcriptional regulator
B446_RS03240	COG2340	Cysteine-rich secretory protein family
B446_RS03245	COG0583	DNA-binding transcription factor activity
B446_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS03255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B446_RS03270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B446_RS03280	COG1316	TRANSCRIPTIONal
B446_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS03325	COG1597	lipid kinase activity
B446_RS03330	COG0277	FAD linked oxidase domain protein
B446_RS03350	COG2124	cytochrome p450
B446_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS03365	COG1295	ribonuclease BN
B446_RS03400	COG1309	transcriptional regulator
B446_RS03440	COG3842	ATPase activity
B446_RS03445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B446_RS03450	COG1176	ABC-type spermidine putrescine transport system, permease component I
B446_RS03455	COG1177	transmembrane transport
B446_RS03490	COG2124	cytochrome p450
B446_RS03505	COG5640	endopeptidase activity
B446_RS03510	COG0583	DNA-binding transcription factor activity
B446_RS03535	COG0586	Pfam SNARE associated Golgi protein
B446_RS03555	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B446_RS03580	COG0375	protein maturation
B446_RS03595	COG0298	carbon dioxide binding
B446_RS03600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B446_RS03610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B446_RS03615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B446_RS03615	COG1024	Enoyl-CoA hydratase
B446_RS03655	COG2208	phosphoserine phosphatase activity
B446_RS03655	COG2770	Histidine kinase
B446_RS03670	COG2755	lipolytic protein G-D-S-L family
B446_RS03690	COG0667	Aldo Keto reductase
B446_RS03700	COG0586	Pfam SNARE associated Golgi protein
B446_RS03715	COG4999	Histidine kinase
B446_RS03715	COG3850	Histidine kinase
B446_RS03715	COG3437	response regulator, receiver
B446_RS03715	COG2205	protein histidine kinase activity
B446_RS03720	COG0437	4 iron, 4 sulfur cluster binding
B446_RS03740	COG0243	molybdopterin cofactor binding
B446_RS03740	COG3383	formate dehydrogenase (NAD+) activity
B446_RS03745	COG3383	formate dehydrogenase (NAD+) activity
B446_RS03745	COG0243	molybdopterin cofactor binding
B446_RS03750	COG0709	Synthesizes selenophosphate from selenide and ATP
B446_RS03795	COG3291	Pkd domain containing protein
B446_RS03815	COG4257	antibiotic catabolic process
B446_RS03850	COG1522	sequence-specific DNA binding
B446_RS03920	COG0009	L-threonylcarbamoyladenylate synthase
B446_RS03955	COG0667	Aldo Keto reductase
B446_RS03960	COG3285	dna ligase
B446_RS03960	COG1793	dna ligase
B446_RS04010	COG0181	hydroxymethylbilane synthase activity
B446_RS04020	COG0842	Transport permease protein
B446_RS04030	COG1846	Transcriptional regulator
B446_RS04065	COG0366	Alpha amylase catalytic
B446_RS04075	COG3281	Trehalose synthase
B446_RS04080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B446_RS04085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B446_RS04105	COG1252	NADH dehydrogenase
B446_RS04180	COG5002	protein histidine kinase activity
B446_RS04185	COG0745	RESPONSE REGULATOR receiver
B446_RS04200	COG3189	MarR family transcriptional regulator
B446_RS04270	COG0142	geranyltranstransferase activity
B446_RS04275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B446_RS04290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS04300	COG3647	Membrane
B446_RS04310	COG0667	Aldo Keto reductase
B446_RS04335	COG2304	oxidoreductase activity
B446_RS04340	COG0328	RNA-DNA hybrid ribonuclease activity
B446_RS04350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B446_RS04360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B446_RS04370	COG0596	Alpha beta hydrolase
B446_RS04380	COG1191	sigma factor activity
B446_RS04410	COG1716	ATPase activity
B446_RS04410	COG1131	(ABC) transporter
B446_RS04410	COG0842	Transport permease protein
B446_RS04425	COG0667	Aldo Keto reductase
B446_RS04430	COG0583	DNA-binding transcription factor activity
B446_RS04440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B446_RS04445	COG0346	lactoylglutathione lyase activity
B446_RS04460	COG0667	Aldo Keto reductase
B446_RS04465	COG4941	Belongs to the sigma-70 factor family
B446_RS04485	COG0702	epimerase
B446_RS04505	COG0531	amino acid
B446_RS04510	COG1940	carbohydrate kinase activity
B446_RS04515	COG3250	beta-galactosidase activity
B446_RS04550	COG0367	asparagine synthase
B446_RS04555	COG2267	carboxylic ester hydrolase activity
B446_RS04565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS04565	COG3320	Male sterility
B446_RS04575	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS04585	COG0673	inositol 2-dehydrogenase activity
B446_RS04605	COG0510	thiamine kinase activity
B446_RS04640	COG1024	Enoyl-CoA hydratase
B446_RS04655	COG0596	Alpha beta hydrolase
B446_RS04665	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS04675	COG2070	2-Nitropropane dioxygenase
B446_RS04685	COG0515	serine threonine protein kinase
B446_RS04735	COG1960	acyl-CoA dehydrogenase activity
B446_RS04750	COG0698	ribose 5-phosphate isomerase
B446_RS04775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B446_RS04775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B446_RS04780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B446_RS04785	COG0297	glycogen (starch) synthase activity
B446_RS04790	COG0438	transferase activity, transferring glycosyl groups
B446_RS04800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B446_RS04810	COG2192	nodulation
B446_RS04815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS04830	COG2376	Dihydroxyacetone kinase
B446_RS04835	COG1461	Dihydroxyacetone kinase
B446_RS04865	COG0446	pyridine nucleotide-disulphide oxidoreductase
B446_RS04865	COG1902	pentaerythritol trinitrate reductase activity
B446_RS04885	COG2890	protein-(glutamine-N5) methyltransferase activity
B446_RS04900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B446_RS04915	COG1215	transferase activity, transferring glycosyl groups
B446_RS04935	COG4941	Belongs to the sigma-70 factor family
B446_RS04970	COG0483	inositol monophosphate 1-phosphatase activity
B446_RS04975	COG0583	DNA-binding transcription factor activity
B446_RS04985	COG3458	cephalosporin-C deacetylase activity
B446_RS04990	COG2188	Transcriptional regulator
B446_RS04995	COG2226	methyltransferase
B446_RS05000	COG1695	Transcriptional regulator
B446_RS05015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B446_RS05020	COG1686	Belongs to the peptidase S11 family
B446_RS05040	COG2066	Belongs to the glutaminase family
B446_RS05055	COG2186	Transcriptional regulator
B446_RS05060	COG1968	undecaprenyl-diphosphatase activity
B446_RS05065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B446_RS05070	COG1993	acr, cog1993
B446_RS05075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B446_RS05100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B446_RS05115	COG4977	sequence-specific DNA binding
B446_RS05130	COG3864	Putative metallopeptidase domain
B446_RS05165	COG2208	phosphoserine phosphatase activity
B446_RS05165	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS05165	COG2172	sigma factor antagonist activity
B446_RS05175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B446_RS05175	COG2080	2 iron, 2 sulfur cluster binding
B446_RS05195	COG0517	IMP dehydrogenase activity
B446_RS05220	COG2130	NADP-dependent
B446_RS05230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS05275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B446_RS05280	COG1215	transferase activity, transferring glycosyl groups
B446_RS05320	COG1349	DNA-binding transcription factor activity
B446_RS05355	COG1940	carbohydrate kinase activity
B446_RS05365	COG2813	Specifically methylates the guanine in position
B446_RS05370	COG0191	fructose-bisphosphate aldolase activity
B446_RS05375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B446_RS05380	COG1349	DNA-binding transcription factor activity
B446_RS05390	COG2223	nitrite transmembrane transporter activity
B446_RS05410	COG2197	response regulator
B446_RS05415	COG4585	Histidine kinase
B446_RS05440	COG0445	tRNA wobble uridine modification
B446_RS05455	COG1660	Displays ATPase and GTPase activities
B446_RS05485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B446_RS05505	COG0204	Acyl-transferase
B446_RS05530	COG0584	glycerophosphoryl diester phosphodiesterase
B446_RS05590	COG1960	acyl-CoA dehydrogenase activity
B446_RS05610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B446_RS05625	COG2706	6-phosphogluconolactonase activity
B446_RS05640	COG0477	Major facilitator Superfamily
B446_RS05665	COG0714	Associated with various cellular activities
B446_RS05710	COG0517	IMP dehydrogenase activity
B446_RS05710	COG0516	GMP reductase activity
B446_RS05725	COG2239	Acts as a magnesium transporter
B446_RS05740	COG2072	flavoprotein involved in K transport
B446_RS05750	COG1132	(ABC) transporter
B446_RS05775	COG1132	(ABC) transporter
B446_RS05785	COG0254	rRNA binding
B446_RS05800	COG1946	Acyl-CoA thioesterase
B446_RS05810	COG2018	Roadblock/LC7 domain
B446_RS05900	COG1940	carbohydrate kinase activity
B446_RS05900	COG1846	Transcriptional regulator
B446_RS05925	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS05995	COG0464	growth
B446_RS06010	COG2197	response regulator
B446_RS06020	COG1408	metallophosphoesterase
B446_RS06060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B446_RS06065	COG0535	radical SAM domain protein
B446_RS06075	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B446_RS06080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B446_RS06090	COG2133	pyrroloquinoline quinone binding
B446_RS06095	COG5434	Belongs to the glycosyl hydrolase 28 family
B446_RS06100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B446_RS06100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B446_RS06135	COG0438	transferase activity, transferring glycosyl groups
B446_RS06140	COG0110	maltose O-acetyltransferase activity
B446_RS06145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B446_RS06195	COG1960	acyl-CoA dehydrogenase activity
B446_RS06200	COG1960	acyl-CoA dehydrogenase activity
B446_RS06210	COG1793	dna ligase
B446_RS06230	COG3424	synthase
B446_RS06235	COG2124	cytochrome p450
B446_RS06245	COG1960	acyl-CoA dehydrogenase activity
B446_RS06255	COG0242	peptide deformylase activity
B446_RS06265	COG3442	glutamine amidotransferase
B446_RS06270	COG0205	6-phosphofructokinase activity
B446_RS06285	COG1522	sequence-specific DNA binding
B446_RS06290	COG1834	amidinotransferase
B446_RS06295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B446_RS06330	COG2197	response regulator
B446_RS06355	COG0829	nickel cation binding
B446_RS06360	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B446_RS06370	COG0804	urea catabolic process
B446_RS06375	COG0832	Belongs to the urease beta subunit family
B446_RS06380	COG0831	urea catabolic process
B446_RS06395	COG0740	serine-type endopeptidase activity
B446_RS06430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B446_RS06435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B446_RS06440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B446_RS06445	COG2226	methyltransferase
B446_RS06460	COG1136	(ABC) transporter
B446_RS06460	COG0577	efflux transmembrane transporter activity
B446_RS06465	COG1136	(ABC) transporter
B446_RS06465	COG0577	efflux transmembrane transporter activity
B446_RS06490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B446_RS06515	COG4585	Histidine kinase
B446_RS06520	COG2197	response regulator
B446_RS06525	COG1940	carbohydrate kinase activity
B446_RS06530	COG2188	Transcriptional regulator
B446_RS06535	COG1595	DNA-templated transcription, initiation
B446_RS06545	COG0596	Alpha beta hydrolase
B446_RS06555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS06580	COG0626	cystathionine gamma-synthase activity
B446_RS06625	COG1522	sequence-specific DNA binding
B446_RS06630	COG0419	ATPase involved in DNA repair
B446_RS06635	COG0420	3'-5' exonuclease activity
B446_RS06640	COG1739	Uncharacterized protein family UPF0029
B446_RS06660	COG1832	CoA-binding protein
B446_RS06665	COG0531	amino acid
B446_RS06670	COG0640	Transcriptional regulator
B446_RS06700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B446_RS06720	COG1819	glycosyl
B446_RS06725	COG0596	Alpha beta hydrolase
B446_RS06750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B446_RS06765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B446_RS06775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B446_RS06795	COG0183	Belongs to the thiolase family
B446_RS06805	COG1968	undecaprenyl-diphosphatase activity
B446_RS06825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B446_RS06845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B446_RS06875	COG0723	plastoquinol--plastocyanin reductase activity
B446_RS06895	COG0697	spore germination
B446_RS06930	COG0384	phenazine biosynthesis protein PhzF
B446_RS06955	COG0395	ABC-type sugar transport system, permease component
B446_RS06960	COG1175	transmembrane transport
B446_RS06990	COG0725	ABC transporter, periplasmic molybdate-binding protein
B446_RS07010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B446_RS07010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B446_RS07020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B446_RS07040	COG1716	ATPase activity
B446_RS07060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B446_RS07090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B446_RS07100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B446_RS07130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B446_RS07135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B446_RS07155	COG2018	Roadblock/LC7 domain
B446_RS07190	COG2814	Major facilitator Superfamily
B446_RS07195	COG4336	lyase activity
B446_RS07200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B446_RS07205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B446_RS07210	COG1984	allophanate hydrolase subunit 2
B446_RS07215	COG2755	lipolytic protein G-D-S-L family
B446_RS07220	COG0438	transferase activity, transferring glycosyl groups
B446_RS07250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS07255	COG2364	Membrane
B446_RS07265	COG2270	Major facilitator Superfamily
B446_RS07280	COG1216	Glycosyl transferase, family 2
B446_RS07315	COG1960	acyl-CoA dehydrogenase activity
B446_RS07370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B446_RS07375	COG0140	phosphoribosyl-ATP diphosphatase activity
B446_RS07380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B446_RS07385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B446_RS07385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B446_RS07390	COG3201	nicotinamide mononucleotide transporter
B446_RS07400	COG1846	Transcriptional regulator
B446_RS07400	COG1940	carbohydrate kinase activity
B446_RS07405	COG2223	nitrite transmembrane transporter activity
B446_RS07420	COG2233	PERMEase
B446_RS07430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS07440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B446_RS07460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B446_RS07465	COG3842	ATPase activity
B446_RS07485	COG2186	Transcriptional regulator
B446_RS07495	COG0531	amino acid
B446_RS07515	COG2390	Transcriptional regulator
B446_RS07520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B446_RS07530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B446_RS07545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B446_RS07560	COG0194	GDP metabolic process
B446_RS07570	COG0284	orotidine-5'-phosphate decarboxylase activity
B446_RS07575	COG0167	dihydroorotate dehydrogenase activity
B446_RS07580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B446_RS07585	COG0505	Belongs to the CarA family
B446_RS07595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B446_RS07600	COG0540	Belongs to the ATCase OTCase family
B446_RS07605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B446_RS07615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B446_RS07620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B446_RS07625	COG0006	proline dipeptidase activity
B446_RS07635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B446_RS07640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B446_RS07645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B446_RS07650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B446_RS07660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B446_RS07665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B446_RS07685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B446_RS07700	COG0124	histidyl-tRNA synthetase
B446_RS07710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B446_RS07715	COG1196	nuclear chromosome segregation
B446_RS07720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B446_RS07730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B446_RS07735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B446_RS07740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B446_RS07750	COG2255	four-way junction helicase activity
B446_RS07755	COG0632	four-way junction helicase activity
B446_RS07760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B446_RS07765	COG0217	transcriptional regulatory protein
B446_RS07770	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B446_RS07775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B446_RS07785	COG0438	transferase activity, transferring glycosyl groups
B446_RS07790	COG1560	Kdo2-lipid A biosynthetic process
B446_RS07795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B446_RS07815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B446_RS07820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B446_RS07835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B446_RS07890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B446_RS07945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B446_RS07945	COG1648	precorrin-2 dehydrogenase activity
B446_RS07950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B446_RS07965	COG1464	Belongs to the NlpA lipoprotein family
B446_RS07970	COG2011	ABC-type metal ion transport system permease component
B446_RS07975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B446_RS08010	COG0204	Acyl-transferase
B446_RS08010	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS08015	COG0477	Major facilitator Superfamily
B446_RS08030	COG0165	Argininosuccinate lyase
B446_RS08060	COG2205	protein histidine kinase activity
B446_RS08065	COG0745	RESPONSE REGULATOR receiver
B446_RS08090	COG1477	protein flavinylation
B446_RS08095	COG1132	(ABC) transporter
B446_RS08110	COG1595	DNA-templated transcription, initiation
B446_RS08115	COG1438	arginine binding
B446_RS08120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B446_RS08125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B446_RS08130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B446_RS08135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B446_RS08180	COG1649	PFAM Uncharacterised BCR, COG1649
B446_RS08215	COG0072	phenylalanine-tRNA ligase activity
B446_RS08215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B446_RS08220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B446_RS08225	COG5002	protein histidine kinase activity
B446_RS08230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B446_RS08235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B446_RS08240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B446_RS08245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B446_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS08295	COG0174	glutamine synthetase
B446_RS08300	COG2186	Transcriptional regulator
B446_RS08305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B446_RS08330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B446_RS08345	COG2124	cytochrome p450
B446_RS08375	COG0805	protein transport
B446_RS08380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B446_RS08400	COG2378	regulation of single-species biofilm formation
B446_RS08415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B446_RS08425	COG1609	Transcriptional regulator
B446_RS08430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B446_RS08440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B446_RS08445	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B446_RS08460	COG4122	O-methyltransferase activity
B446_RS08465	COG1222	aaa ATPase
B446_RS08485	COG0517	IMP dehydrogenase activity
B446_RS08485	COG1994	Peptidase M50
B446_RS08495	COG2197	response regulator
B446_RS08500	COG0747	negative chemotaxis
B446_RS08510	COG0646	methionine synthase
B446_RS08510	COG1410	methionine synthase
B446_RS08515	COG1414	Transcriptional regulator
B446_RS08520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B446_RS08525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B446_RS08530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B446_RS08545	COG0215	cysteine-tRNA ligase activity
B446_RS08560	COG0406	alpha-ribazole phosphatase activity
B446_RS08565	COG0598	Magnesium transport protein CorA
B446_RS08575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS08580	COG0667	Aldo Keto reductase
B446_RS08610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B446_RS08630	COG3012	SEC-C Motif Domain Protein
B446_RS08640	COG3265	gluconokinase activity
B446_RS08670	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B446_RS08675	COG2149	membrane
B446_RS08720	COG0019	diaminopimelate decarboxylase activity
B446_RS08735	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS08745	COG3876	Protein conserved in bacteria
B446_RS08795	COG1960	acyl-CoA dehydrogenase activity
B446_RS08805	COG0640	Transcriptional regulator
B446_RS08840	COG0243	molybdopterin cofactor binding
B446_RS08845	COG1309	transcriptional regulator
B446_RS08855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B446_RS08860	COG2188	Transcriptional regulator
B446_RS08870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B446_RS08885	COG1595	DNA-templated transcription, initiation
B446_RS08910	COG2755	lipolytic protein G-D-S-L family
B446_RS08930	COG0726	polysaccharide deacetylase
B446_RS08955	COG1725	Transcriptional regulator
B446_RS08995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B446_RS08995	COG0662	Cupin 2, conserved barrel domain protein
B446_RS09005	COG0587	DNA-directed DNA polymerase activity
B446_RS09020	COG1799	cell septum assembly
B446_RS09025	COG1960	acyl-CoA dehydrogenase activity
B446_RS09030	COG0477	Major facilitator Superfamily
B446_RS09040	COG0671	phosphoesterase, PA-phosphatase related
B446_RS09055	COG3583	domain protein
B446_RS09070	COG1160	GTP binding
B446_RS09080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B446_RS09100	COG3541	Predicted nucleotidyltransferase
B446_RS09105	COG1187	pseudouridine synthase activity
B446_RS09110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B446_RS09115	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B446_RS09130	COG0686	Belongs to the AlaDH PNT family
B446_RS09140	COG0494	nUDIX hydrolase
B446_RS09145	COG0504	CTP synthase activity
B446_RS09150	COG3387	PFAM Glycoside hydrolase 15-related
B446_RS09165	COG0297	glycogen (starch) synthase activity
B446_RS09175	COG0497	DNA recombination
B446_RS09180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B446_RS09200	COG1120	ATPase activity
B446_RS09205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B446_RS09210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B446_RS09215	COG0647	UMP catabolic process
B446_RS09250	COG2094	Belongs to the DNA glycosylase MPG family
B446_RS09260	COG1881	PFAM PEBP family protein
B446_RS09280	COG1119	ATPase activity
B446_RS09295	COG2197	response regulator
B446_RS09300	COG4585	Histidine kinase
B446_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS09310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B446_RS09320	COG1131	(ABC) transporter
B446_RS09320	COG0842	Transport permease protein
B446_RS09320	COG1716	ATPase activity
B446_RS09330	COG3830	Belongs to the UPF0237 family
B446_RS09330	COG0560	Phosphoserine phosphatase
B446_RS09350	COG2186	Transcriptional regulator
B446_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS09390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B446_RS09410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B446_RS09415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS09430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B446_RS09465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B446_RS09515	COG1024	Enoyl-CoA hydratase
B446_RS09525	COG0488	(ABC) transporter
B446_RS09545	COG0235	Class ii aldolase
B446_RS09565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B446_RS09570	COG1492	cobalamin metabolic process
B446_RS09590	COG1797	cobyrinic acid a,c-diamide synthase activity
B446_RS09625	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B446_RS09650	COG0765	amino acid transport
B446_RS09655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B446_RS09665	COG0456	acetyltransferase
B446_RS09670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B446_RS09675	COG1917	Cupin 2, conserved barrel domain protein
B446_RS09680	COG5285	phytanoyl-CoA dioxygenase
B446_RS09705	COG1414	Transcriptional regulator
B446_RS09725	COG2252	PERMEase
B446_RS09745	COG1802	Transcriptional regulator
B446_RS09775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B446_RS09780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS09785	COG1349	DNA-binding transcription factor activity
B446_RS09800	COG0395	ABC-type sugar transport system, permease component
B446_RS09805	COG1063	alcohol dehydrogenase
B446_RS09865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B446_RS09900	COG2171	N-acyltransferase activity
B446_RS09905	COG3226	Transcriptional regulator
B446_RS09910	COG2076	Multidrug Resistance protein
B446_RS09920	COG2151	metal-sulfur cluster biosynthetic enzyme
B446_RS09925	COG0822	iron-sulfur transferase activity
B446_RS09930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B446_RS09935	COG0396	ATPase activity
B446_RS09945	COG0719	Fe-S assembly protein
B446_RS09960	COG2746	aminoglycoside 3-N-acetyltransferase activity
B446_RS09975	COG1612	heme a metabolic process
B446_RS09995	COG0109	protoheme IX farnesyltransferase activity
B446_RS10005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B446_RS10020	COG0363	glucosamine-6-phosphate deaminase activity
B446_RS10025	COG0395	ABC-type sugar transport system, permease component
B446_RS10030	COG1175	transmembrane transport
B446_RS10035	COG1653	transport
B446_RS10040	COG0366	Alpha amylase catalytic
B446_RS10045	COG1653	transport
B446_RS10050	COG1695	Transcriptional regulator
B446_RS10055	COG0577	efflux transmembrane transporter activity
B446_RS10055	COG1136	(ABC) transporter
B446_RS10065	COG0166	Belongs to the GPI family
B446_RS10075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B446_RS10080	COG0149	triose-phosphate isomerase activity
B446_RS10085	COG0126	phosphoglycerate kinase activity
B446_RS10090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B446_RS10100	COG1481	regulation of sporulation
B446_RS10105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B446_RS10110	COG1660	Displays ATPase and GTPase activities
B446_RS10115	COG0322	excinuclease ABC activity
B446_RS10130	COG1609	Transcriptional regulator
B446_RS10140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B446_RS10155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B446_RS10160	COG0765	amino acid transport
B446_RS10170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B446_RS10175	COG0477	Major facilitator Superfamily
B446_RS10180	COG0387	Pfam Sodium calcium exchanger
B446_RS10200	COG0556	nucleotide-excision repair
B446_RS10210	COG0584	glycerophosphoryl diester phosphodiesterase
B446_RS10215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B446_RS10225	COG2313	pseudouridylate synthase activity
B446_RS10235	COG2226	methyltransferase
B446_RS10240	COG0598	Magnesium transport protein CorA
B446_RS10340	COG0237	dephospho-CoA kinase activity
B446_RS10355	COG0539	negative regulation of cytoplasmic translation
B446_RS10365	COG1643	Atp-dependent helicase
B446_RS10405	COG2050	protein possibly involved in aromatic compounds catabolism
B446_RS10465	COG0737	Belongs to the 5'-nucleotidase family
B446_RS10490	COG1605	Chorismate mutase
B446_RS10490	COG0287	Prephenate dehydrogenase
B446_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS10520	COG1024	Enoyl-CoA hydratase
B446_RS10540	COG0183	Belongs to the thiolase family
B446_RS10545	COG1309	transcriptional regulator
B446_RS10550	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS10555	COG1960	acyl-CoA dehydrogenase activity
B446_RS10560	COG1960	acyl-CoA dehydrogenase activity
B446_RS10575	COG0067	glutamate synthase
B446_RS10575	COG0069	glutamate synthase activity
B446_RS10575	COG0070	glutamate synthase
B446_RS10605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B446_RS10610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B446_RS10620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B446_RS10630	COG0159	tryptophan synthase activity
B446_RS10635	COG0133	tryptophan synthase activity
B446_RS10645	COG0134	indole-3-glycerol-phosphate synthase activity
B446_RS10665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B446_RS10670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B446_RS10695	COG0107	imidazoleglycerol-phosphate synthase activity
B446_RS10700	COG0251	oxidation-reduction process
B446_RS10705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B446_RS10710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B446_RS10720	COG0131	Imidazoleglycerol-phosphate dehydratase
B446_RS10725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B446_RS10730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B446_RS10750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B446_RS10770	COG1432	Conserved Protein
B446_RS10775	COG0587	DNA-directed DNA polymerase activity
B446_RS10815	COG2153	protein acetylation
B446_RS10825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B446_RS10840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B446_RS10855	COG1799	cell septum assembly
B446_RS10865	COG1496	oxidoreductase activity
B446_RS10870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B446_RS10880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B446_RS10890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B446_RS10895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B446_RS10905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B446_RS10910	COG0768	penicillin binding
B446_RS10920	COG0275	rRNA processing
B446_RS10930	COG0714	Associated with various cellular activities
B446_RS10950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B446_RS10960	COG1122	ATPase activity
B446_RS10970	COG1309	transcriptional regulator
B446_RS10995	COG0352	thiamine-phosphate diphosphorylase activity
B446_RS11015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B446_RS11015	COG2022	thiamine diphosphate biosynthetic process
B446_RS11025	COG2022	thiamine diphosphate biosynthetic process
B446_RS11030	COG0515	serine threonine protein kinase
B446_RS11030	COG2815	serine threonine protein kinase
B446_RS11035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B446_RS11040	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B446_RS11045	COG2193	ferroxidase activity
B446_RS11050	COG0243	molybdopterin cofactor binding
B446_RS11055	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B446_RS11065	COG0205	6-phosphofructokinase activity
B446_RS11075	COG4585	Histidine kinase
B446_RS11100	COG1940	carbohydrate kinase activity
B446_RS11110	COG0003	Pfam Anion-transporting ATPase
B446_RS11155	COG3883	PFAM NLP P60 protein
B446_RS11155	COG0791	NLP P60 protein
B446_RS11185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B446_RS11190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B446_RS11195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B446_RS11200	COG0723	plastoquinol--plastocyanin reductase activity
B446_RS11205	COG2010	Cytochrome c
B446_RS11210	COG1845	cytochrome c oxidase, subunit III
B446_RS11220	COG1376	ErfK ybiS ycfS ynhG family protein
B446_RS11230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B446_RS11235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B446_RS11245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B446_RS11265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B446_RS11275	COG0515	serine threonine protein kinase
B446_RS11275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B446_RS11280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B446_RS11285	COG2197	response regulator
B446_RS11330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B446_RS11335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B446_RS11335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B446_RS11350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B446_RS11365	COG0438	transferase activity, transferring glycosyl groups
B446_RS11375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B446_RS11380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B446_RS11385	COG0508	dehydrogenase complex catalyzes the overall conversion of
B446_RS11395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B446_RS11430	COG1090	epimerase
B446_RS11445	COG0321	lipoyl(octanoyl) transferase activity
B446_RS11450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B446_RS11470	COG0174	glutamine synthetase
B446_RS11480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B446_RS11490	COG0640	Transcriptional regulator
B446_RS11510	COG0501	Belongs to the peptidase M48B family
B446_RS11560	COG0745	RESPONSE REGULATOR receiver
B446_RS11575	COG2197	response regulator
B446_RS11610	COG1309	transcriptional regulator
B446_RS11640	COG0366	Alpha amylase catalytic
B446_RS11645	COG3833	ABC-type maltose transport systems, permease component
B446_RS11650	COG1175	transmembrane transport
B446_RS11660	COG1609	Transcriptional regulator
B446_RS11670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B446_RS11680	COG3511	phospholipase C
B446_RS11715	COG1051	belongs to the nudix hydrolase family
B446_RS11725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B446_RS11730	COG0174	glutamine synthetase
B446_RS11740	COG1959	2 iron, 2 sulfur cluster binding
B446_RS11785	COG2814	Major facilitator Superfamily
B446_RS11800	COG0477	Major facilitator Superfamily
B446_RS11805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B446_RS11830	COG1994	Peptidase M50
B446_RS11885	COG2837	iron assimilation
B446_RS11890	COG0672	)-iron permease
B446_RS11915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B446_RS11920	COG2814	Major facilitator Superfamily
B446_RS11935	COG1686	Belongs to the peptidase S11 family
B446_RS11945	COG2259	Doxx family
B446_RS11975	COG0557	exoribonuclease II activity
B446_RS11980	COG3022	response to hydroperoxide
B446_RS11985	COG0800	Aldolase
B446_RS12000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B446_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS12020	COG2030	dehydratase
B446_RS12025	COG4585	Histidine kinase
B446_RS12035	COG2197	response regulator
B446_RS12055	COG0183	Belongs to the thiolase family
B446_RS12060	COG0477	Major facilitator Superfamily
B446_RS12070	COG0860	N-Acetylmuramoyl-L-alanine amidase
B446_RS12070	COG2247	cell wall binding repeat
B446_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS12105	COG0438	transferase activity, transferring glycosyl groups
B446_RS12110	COG1309	transcriptional regulator
B446_RS12165	COG3845	ABC transporter
B446_RS12180	COG3619	membrane
B446_RS12185	COG2124	cytochrome p450
B446_RS12190	COG0183	Belongs to the thiolase family
B446_RS12200	COG4122	O-methyltransferase activity
B446_RS12245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B446_RS12275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B446_RS12310	COG1358	cellular component organization or biogenesis
B446_RS12355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B446_RS12360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B446_RS12370	COG0477	Major facilitator Superfamily
B446_RS12375	COG1309	transcriptional regulator
B446_RS12390	COG0789	Transcriptional regulator
B446_RS12405	COG1741	Belongs to the pirin family
B446_RS12420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B446_RS12425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS12430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B446_RS12475	COG2130	NADP-dependent
B446_RS12480	COG1764	response to oxidative stress
B446_RS12495	COG4948	Mandelate Racemase Muconate Lactonizing
B446_RS12520	COG4214	carbohydrate transport
B446_RS12530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B446_RS12565	COG3386	PFAM SMP-30 Gluconolaconase
B446_RS12570	COG1414	Transcriptional regulator
B446_RS12595	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS12600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B446_RS12600	COG0825	malonyl-CoA metabolic process
B446_RS12605	COG1404	Belongs to the peptidase S8 family
B446_RS12615	COG1077	Cell shape determining protein MreB Mrl
B446_RS12660	COG1070	Carbohydrate kinase
B446_RS12675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B446_RS12680	COG0358	DNA primase activity
B446_RS12690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B446_RS12700	COG2949	membrane
B446_RS12705	COG0243	molybdopterin cofactor binding
B446_RS12730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B446_RS12735	COG2146	nitrite reductase [NAD(P)H] activity
B446_RS12735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B446_RS12745	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS12765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B446_RS12765	COG0574	Belongs to the PEP-utilizing enzyme family
B446_RS12770	COG1940	carbohydrate kinase activity
B446_RS12770	COG1846	Transcriptional regulator
B446_RS12775	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B446_RS12805	COG0477	Major facilitator Superfamily
B446_RS12820	COG0667	Aldo Keto reductase
B446_RS12835	COG0423	glycine-tRNA ligase activity
B446_RS12845	COG1120	ATPase activity
B446_RS12850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B446_RS12860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B446_RS12865	COG1381	Involved in DNA repair and RecF pathway recombination
B446_RS12875	COG0747	negative chemotaxis
B446_RS12885	COG0444	Belongs to the ABC transporter superfamily
B446_RS12890	COG4608	Belongs to the ABC transporter superfamily
B446_RS12895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B446_RS12975	COG2197	response regulator
B446_RS12980	COG4585	Histidine kinase
B446_RS12985	COG2409	Drug exporters of the RND superfamily
B446_RS12995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B446_RS13020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B446_RS13070	COG2315	Protein conserved in bacteria
B446_RS13080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B446_RS13090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B446_RS13095	COG4948	Mandelate Racemase Muconate Lactonizing
B446_RS13100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B446_RS13115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B446_RS13120	COG1234	tRNA 3'-trailer cleavage
B446_RS13125	COG0537	adenosine 5'-monophosphoramidase activity
B446_RS13130	COG0793	Belongs to the peptidase S41A family
B446_RS13130	COG4946	Tricorn protease homolog
B446_RS13150	COG2070	2-Nitropropane dioxygenase
B446_RS13155	COG0484	heat shock protein binding
B446_RS13160	COG1420	regulation of RNA biosynthetic process
B446_RS13195	COG0481	GTPase activity
B446_RS13200	COG0268	Binds directly to 16S ribosomal RNA
B446_RS13230	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS13240	COG2197	response regulator
B446_RS13265	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B446_RS13270	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B446_RS13275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B446_RS13280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B446_RS13315	COG0667	Aldo Keto reductase
B446_RS13355	COG1131	(ABC) transporter
B446_RS13375	COG1819	glycosyl
B446_RS13395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS13410	COG0431	NADPH-dependent FMN reductase
B446_RS13455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B446_RS13480	COG1307	EDD domain protein, DegV family
B446_RS13490	COG0495	leucyl-tRNA aminoacylation
B446_RS13500	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B446_RS13540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B446_RS13555	COG0501	Belongs to the peptidase M48B family
B446_RS13570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B446_RS13580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B446_RS13590	COG1215	transferase activity, transferring glycosyl groups
B446_RS13605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B446_RS13610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B446_RS13615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B446_RS13620	COG1530	ribonuclease E activity
B446_RS13645	COG3152	Membrane
B446_RS13685	COG1917	Cupin 2, conserved barrel domain protein
B446_RS13685	COG1396	sequence-specific DNA binding
B446_RS13700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B446_RS13700	COG0072	phenylalanine-tRNA ligase activity
B446_RS13745	COG0546	phosphoglycolate phosphatase activity
B446_RS13750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B446_RS13750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B446_RS13780	COG0772	Belongs to the SEDS family
B446_RS13785	COG0768	penicillin binding
B446_RS13800	COG1077	Cell shape determining protein MreB Mrl
B446_RS13805	COG0105	UTP biosynthetic process
B446_RS13815	COG0285	dihydrofolate synthase activity
B446_RS13820	COG0525	valine-tRNA ligase activity
B446_RS13830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B446_RS13835	COG0740	serine-type endopeptidase activity
B446_RS13840	COG0740	serine-type endopeptidase activity
B446_RS13845	COG0544	peptidyl-prolyl cis-trans isomerase activity
B446_RS13865	COG3594	Acyltransferase
B446_RS13875	COG1136	(ABC) transporter
B446_RS13885	COG4552	Acetyltransferase involved in intracellular survival and related
B446_RS13900	COG1113	amino acid transport
B446_RS13905	COG0515	serine threonine protein kinase
B446_RS13920	COG1940	carbohydrate kinase activity
B446_RS13930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B446_RS13935	COG1116	anion transmembrane transporter activity
B446_RS13940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS13950	COG1113	amino acid transport
B446_RS13955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B446_RS13960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B446_RS14030	COG0697	spore germination
B446_RS14040	COG1846	Transcriptional regulator
B446_RS14060	COG1595	DNA-templated transcription, initiation
B446_RS14070	COG1131	(ABC) transporter
B446_RS14090	COG0668	transmembrane transport
B446_RS14100	COG1653	transport
B446_RS14105	COG1175	transmembrane transport
B446_RS14110	COG0395	ABC-type sugar transport system, permease component
B446_RS14115	COG1486	melibiose metabolic process
B446_RS14165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B446_RS14215	COG0629	single-stranded DNA binding
B446_RS14255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B446_RS14310	COG0297	glycogen (starch) synthase activity
B446_RS14315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B446_RS14335	COG0438	transferase activity, transferring glycosyl groups
B446_RS14390	COG1131	(ABC) transporter
B446_RS14405	COG3962	Belongs to the TPP enzyme family
B446_RS14410	COG3718	enzyme involved in inositol metabolism
B446_RS14435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B446_RS14440	COG1063	alcohol dehydrogenase
B446_RS14445	COG2409	Drug exporters of the RND superfamily
B446_RS14475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B446_RS14485	COG1129	ABC transporter
B446_RS14495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B446_RS14500	COG1869	D-ribose catabolic process
B446_RS14515	COG0673	inositol 2-dehydrogenase activity
B446_RS14520	COG1609	Transcriptional regulator
B446_RS14535	COG1472	Belongs to the glycosyl hydrolase 3 family
B446_RS14565	COG0028	Belongs to the TPP enzyme family
B446_RS14575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS14595	COG1946	Acyl-CoA thioesterase
B446_RS14605	COG1309	transcriptional regulator
B446_RS14610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B446_RS14625	COG1960	acyl-CoA dehydrogenase activity
B446_RS14645	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B446_RS14680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B446_RS14690	COG0589	response to stress
B446_RS14700	COG4977	sequence-specific DNA binding
B446_RS14705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B446_RS14740	COG3979	chitinase
B446_RS14775	COG0406	alpha-ribazole phosphatase activity
B446_RS14820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS14835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B446_RS14840	COG0154	amidase activity
B446_RS14850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B446_RS14855	COG0765	amino acid transport
B446_RS14860	COG0765	amino acid transport
B446_RS14865	COG1126	abc transporter atp-binding protein
B446_RS14895	COG3397	chitin binding
B446_RS14915	COG2186	Transcriptional regulator
B446_RS14940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B446_RS14945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B446_RS14950	COG2188	Transcriptional regulator
B446_RS14965	COG1940	carbohydrate kinase activity
B446_RS14970	COG0673	inositol 2-dehydrogenase activity
B446_RS14975	COG4702	Belongs to the UPF0303 family
B446_RS15010	COG3764	Sortase (surface protein transpeptidase)
B446_RS15075	COG2733	membrane
B446_RS15080	COG2271	Major facilitator Superfamily
B446_RS15085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B446_RS15125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B446_RS15140	COG1131	(ABC) transporter
B446_RS15155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B446_RS15160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B446_RS15165	COG1263	PTS System
B446_RS15170	COG1263	PTS System
B446_RS15210	COG1113	amino acid transport
B446_RS15220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B446_RS15230	COG1335	isochorismatase
B446_RS15265	COG0277	FAD linked oxidase domain protein
B446_RS15280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B446_RS15320	COG1584	GPR1 FUN34 yaaH family protein
B446_RS15345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B446_RS15355	COG1678	Uncharacterized ACR, COG1678
B446_RS15360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B446_RS15365	COG0776	regulation of translation
B446_RS15375	COG3973	AAA domain
B446_RS15405	COG2223	nitrite transmembrane transporter activity
B446_RS15410	COG0583	DNA-binding transcription factor activity
B446_RS15420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B446_RS15425	COG0793	Belongs to the peptidase S41A family
B446_RS15430	COG2177	Part of the ABC transporter FtsEX involved in
B446_RS15435	COG2884	Cell division ATP-binding protein ftsE
B446_RS15450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B446_RS15455	COG0515	serine threonine protein kinase
B446_RS15460	COG0515	serine threonine protein kinase
B446_RS15465	COG1674	ftsk spoiiie
B446_RS15475	COG1175	transmembrane transport
B446_RS15480	COG0395	ABC-type sugar transport system, permease component
B446_RS15485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B446_RS15485	COG0463	Glycosyl transferase, family 2
B446_RS15490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B446_RS15495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B446_RS15500	COG1764	response to oxidative stress
B446_RS15505	COG1846	Transcriptional regulator
B446_RS15520	COG1215	transferase activity, transferring glycosyl groups
B446_RS15540	COG1134	teichoic acid transport
B446_RS15545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B446_RS15550	COG1215	transferase activity, transferring glycosyl groups
B446_RS15565	COG2902	Dehydrogenase
B446_RS15590	COG0653	protein targeting
B446_RS15600	COG3214	Protein conserved in bacteria
B446_RS15605	COG2197	response regulator
B446_RS15610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B446_RS15620	COG0823	Involved in the tonB-independent uptake of proteins
B446_RS15625	COG5000	phosphorelay sensor kinase activity
B446_RS15625	COG5002	protein histidine kinase activity
B446_RS15630	COG0745	RESPONSE REGULATOR receiver
B446_RS15635	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B446_RS15655	COG0714	Associated with various cellular activities
B446_RS15695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B446_RS15705	COG1482	cell wall glycoprotein biosynthetic process
B446_RS15715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B446_RS15755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B446_RS15760	COG0778	Nitroreductase
B446_RS15760	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B446_RS15785	COG1316	TRANSCRIPTIONal
B446_RS15790	COG1316	TRANSCRIPTIONal
B446_RS15800	COG1316	TRANSCRIPTIONal
B446_RS15810	COG1316	TRANSCRIPTIONal
B446_RS15830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B446_RS15870	COG2205	protein histidine kinase activity
B446_RS15875	COG0745	RESPONSE REGULATOR receiver
B446_RS15880	COG3104	oligopeptide transport
B446_RS15910	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS15915	COG1191	sigma factor activity
B446_RS15925	COG1228	amidohydrolase
B446_RS15940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B446_RS15975	COG2986	histidine ammonia-lyase
B446_RS15990	COG2755	lipolytic protein G-D-S-L family
B446_RS15995	COG0183	Belongs to the thiolase family
B446_RS16025	COG0577	efflux transmembrane transporter activity
B446_RS16025	COG1136	(ABC) transporter
B446_RS16030	COG0577	efflux transmembrane transporter activity
B446_RS16035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B446_RS16040	COG1252	NADH dehydrogenase
B446_RS16060	COG0148	phosphopyruvate hydratase activity
B446_RS16130	COG0577	efflux transmembrane transporter activity
B446_RS16135	COG1136	(ABC) transporter
B446_RS16140	COG0477	Major facilitator Superfamily
B446_RS16150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS16185	COG4585	Histidine kinase
B446_RS16200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B446_RS16205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B446_RS16210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B446_RS16215	COG0193	aminoacyl-tRNA hydrolase activity
B446_RS16225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B446_RS16235	COG1309	transcriptional regulator
B446_RS16245	COG4106	trans-aconitate 2-methyltransferase activity
B446_RS16255	COG2197	response regulator
B446_RS16270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B446_RS16310	COG0488	(ABC) transporter
B446_RS16320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B446_RS16325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B446_RS16330	COG3583	domain protein
B446_RS16330	COG3584	3D domain protein
B446_RS16335	COG0084	hydrolase, TatD family'
B446_RS16365	COG0310	cobalt ion transport
B446_RS16375	COG1122	ATPase activity
B446_RS16380	COG1846	Transcriptional regulator
B446_RS16385	COG1764	response to oxidative stress
B446_RS16405	COG0442	prolyl-tRNA aminoacylation
B446_RS16410	COG2409	Drug exporters of the RND superfamily
B446_RS16420	COG4946	Tricorn protease homolog
B446_RS16420	COG0793	Belongs to the peptidase S41A family
B446_RS16430	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS16435	COG2267	carboxylic ester hydrolase activity
B446_RS16440	COG2072	flavoprotein involved in K transport
B446_RS16460	COG0708	Exodeoxyribonuclease III
B446_RS16465	COG0454	-acetyltransferase
B446_RS16480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B446_RS16485	COG0521	Mo-molybdopterin cofactor biosynthetic process
B446_RS16485	COG0315	cyclic pyranopterin monophosphate synthase activity
B446_RS16490	COG0315	cyclic pyranopterin monophosphate synthase activity
B446_RS16500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B446_RS16505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B446_RS16520	COG0477	Major facilitator Superfamily
B446_RS16530	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B446_RS16540	COG1970	mechanosensitive ion channel activity
B446_RS16555	COG3191	aminopeptidase activity
B446_RS16575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B446_RS16575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B446_RS16585	COG1349	DNA-binding transcription factor activity
B446_RS16590	COG0477	Major facilitator Superfamily
B446_RS16595	COG2378	regulation of single-species biofilm formation
B446_RS16610	COG3384	dioxygenase
B446_RS16615	COG1846	Transcriptional regulator
B446_RS16640	COG0582	viral genome integration into host DNA
B446_RS16685	COG2188	Transcriptional regulator
B446_RS16705	COG0582	viral genome integration into host DNA
B446_RS16745	COG2318	DinB family
B446_RS16770	COG1595	DNA-templated transcription, initiation
B446_RS16785	COG0330	HflC and HflK could
B446_RS16790	COG0386	Belongs to the glutathione peroxidase family
B446_RS16810	COG1686	Belongs to the peptidase S11 family
B446_RS16825	COG0300	oxidoreductase activity
B446_RS16865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B446_RS16890	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B446_RS16915	COG3629	intracellular signal transduction
B446_RS16915	COG3903	Transcriptional regulator
B446_RS16940	COG1024	Enoyl-CoA hydratase
B446_RS16950	COG0515	serine threonine protein kinase
B446_RS16950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B446_RS16960	COG1309	transcriptional regulator
B446_RS16965	COG1522	sequence-specific DNA binding
B446_RS16970	COG1280	lysine exporter protein (LysE YggA)
B446_RS16980	COG1960	acyl-CoA dehydrogenase activity
B446_RS16990	COG0259	pyridoxamine-phosphate oxidase activity
B446_RS17005	COG2072	flavoprotein involved in K transport
B446_RS17015	COG1024	Enoyl-CoA hydratase
B446_RS17025	COG2814	Major facilitator Superfamily
B446_RS17035	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B446_RS17040	COG1960	acyl-CoA dehydrogenase activity
B446_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS17060	COG1960	acyl-CoA dehydrogenase activity
B446_RS17065	COG1960	acyl-CoA dehydrogenase activity
B446_RS17075	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS17085	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS17135	COG1131	(ABC) transporter
B446_RS17145	COG0596	Alpha beta hydrolase
B446_RS17145	COG2945	thiolester hydrolase activity
B446_RS17155	COG4821	SIS domain
B446_RS17170	COG0259	pyridoxamine-phosphate oxidase activity
B446_RS17195	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS17210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B446_RS17225	COG5006	permease, DMT superfamily
B446_RS17230	COG0247	lactate metabolic process
B446_RS17230	COG0277	FAD linked oxidase domain protein
B446_RS17235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B446_RS17255	COG0667	Aldo Keto reductase
B446_RS17280	COG2252	PERMEase
B446_RS17290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B446_RS17335	COG2814	Major facilitator Superfamily
B446_RS17345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B446_RS17350	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B446_RS17355	COG1278	Cold shock
B446_RS17385	COG1061	Type III restriction enzyme res subunit
B446_RS17400	COG3973	AAA domain
B446_RS17430	COG1737	Transcriptional regulator
B446_RS17435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B446_RS17440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B446_RS17440	COG1263	PTS System
B446_RS17475	COG0459	protein refolding
B446_RS17480	COG1278	Cold shock
B446_RS17495	COG0463	Glycosyl transferase, family 2
B446_RS17540	COG5001	Diguanylate cyclase
B446_RS17540	COG3300	MHYT domain
B446_RS17625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS17630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B446_RS17640	COG0662	Cupin 2, conserved barrel domain protein
B446_RS17645	COG2329	Antibiotic biosynthesis monooxygenase
B446_RS17660	COG3842	ATPase activity
B446_RS17685	COG0215	cysteine-tRNA ligase activity
B446_RS17695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B446_RS17700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B446_RS17705	COG1329	Transcriptional regulator
B446_RS17720	COG5002	protein histidine kinase activity
B446_RS17775	COG0789	Transcriptional regulator
B446_RS17810	COG0222	ribosome binding
B446_RS17815	COG0588	phosphoglycerate mutase activity
B446_RS17845	COG0438	transferase activity, transferring glycosyl groups
B446_RS17890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B446_RS17900	COG0546	phosphoglycolate phosphatase activity
B446_RS17915	COG2188	Transcriptional regulator
B446_RS17925	COG2188	Transcriptional regulator
B446_RS17930	COG4552	Acetyltransferase involved in intracellular survival and related
B446_RS17940	COG1490	D-aminoacyl-tRNA deacylase activity
B446_RS17950	COG0735	belongs to the Fur family
B446_RS17955	COG3485	protocatechuate 3,4-dioxygenase
B446_RS17980	COG2897	thiosulfate sulfurtransferase activity
B446_RS18005	COG0745	RESPONSE REGULATOR receiver
B446_RS18010	COG1609	Transcriptional regulator
B446_RS18015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B446_RS18025	COG0745	RESPONSE REGULATOR receiver
B446_RS18035	COG0737	Belongs to the 5'-nucleotidase family
B446_RS18040	COG0456	acetyltransferase
B446_RS18045	COG1725	Transcriptional regulator
B446_RS18050	COG3842	ATPase activity
B446_RS18065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B446_RS18075	COG0406	alpha-ribazole phosphatase activity
B446_RS18075	COG0494	nUDIX hydrolase
B446_RS18085	COG1937	Protein conserved in bacteria
B446_RS18095	COG0306	phosphate transporter
B446_RS18100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B446_RS18120	COG0277	FAD linked oxidase domain protein
B446_RS18125	COG0671	phosphoesterase, PA-phosphatase related
B446_RS18175	COG0456	acetyltransferase
B446_RS18215	COG1252	NADH dehydrogenase
B446_RS18225	COG1470	cell adhesion involved in biofilm formation
B446_RS18225	COG0366	Alpha amylase catalytic
B446_RS18245	COG0579	oxidoreductase
B446_RS18250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B446_RS18260	COG0667	Aldo Keto reductase
B446_RS18280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B446_RS18280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B446_RS18290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B446_RS18305	COG0667	Aldo Keto reductase
B446_RS18350	COG1643	Atp-dependent helicase
B446_RS18385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B446_RS18405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B446_RS18410	COG0047	phosphoribosylformylglycinamidine synthase activity
B446_RS18415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B446_RS18445	COG3851	Histidine kinase
B446_RS18450	COG2197	response regulator
B446_RS18460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B446_RS18475	COG0151	Belongs to the GarS family
B446_RS18520	COG2372	response to copper ion
B446_RS18520	COG1276	copper resistance
B446_RS18550	COG0433	COG0433 Predicted ATPase
B446_RS18565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B446_RS18600	COG1191	sigma factor activity
B446_RS18605	COG1191	sigma factor activity
B446_RS18625	COG0477	Major facilitator Superfamily
B446_RS18630	COG2353	YceI-like domain
B446_RS18645	COG3467	pyridoxamine 5'-phosphate
B446_RS18655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B446_RS18665	COG2205	protein histidine kinase activity
B446_RS18670	COG0745	RESPONSE REGULATOR receiver
B446_RS18685	COG1846	Transcriptional regulator
B446_RS18725	COG0784	Response regulator, receiver
B446_RS18730	COG1309	transcriptional regulator
B446_RS18740	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS18745	COG1595	DNA-templated transcription, initiation
B446_RS18785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B446_RS18800	COG0653	protein targeting
B446_RS18820	COG0006	proline dipeptidase activity
B446_RS18825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS18875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B446_RS18880	COG0561	phosphatase activity
B446_RS18910	COG1131	(ABC) transporter
B446_RS18925	COG0789	Transcriptional regulator
B446_RS18930	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B446_RS18940	COG0561	phosphatase activity
B446_RS18945	COG4988	ABC transporter
B446_RS18950	COG1294	oxidase, subunit
B446_RS18955	COG1271	oxidase subunit
B446_RS18965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B446_RS18970	COG1609	Transcriptional regulator
B446_RS18975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B446_RS18985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B446_RS19010	COG0662	Cupin 2, conserved barrel domain protein
B446_RS19015	COG1950	PFAM Membrane protein of
B446_RS19020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B446_RS19025	COG0626	cystathionine gamma-synthase activity
B446_RS19055	COG2814	Major facilitator Superfamily
B446_RS19080	COG0305	Participates in initiation and elongation during chromosome replication
B446_RS19090	COG0359	binds to the 23S rRNA
B446_RS19095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B446_RS19100	COG0629	single-stranded DNA binding
B446_RS19105	COG0360	Binds together with S18 to 16S ribosomal RNA
B446_RS19130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B446_RS19150	COG0617	tRNA 3'-terminal CCA addition
B446_RS19165	COG2815	serine threonine protein kinase
B446_RS19165	COG0515	serine threonine protein kinase
B446_RS19170	COG1595	DNA-templated transcription, initiation
B446_RS19180	COG0492	ferredoxin-NADP+ reductase activity
B446_RS19185	COG3118	belongs to the thioredoxin family
B446_RS19200	COG1192	Involved in chromosome partitioning
B446_RS19205	COG0357	Ribosomal RNA small subunit methyltransferase G
B446_RS19215	COG0706	membrane insertase activity
B446_RS19220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B446_RS19235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B446_RS19240	COG0592	DNA-directed DNA polymerase activity
B446_RS19245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B446_RS19250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B446_RS19255	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B446_RS19260	COG0187	DNA topoisomerase II activity
B446_RS19265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B446_RS19290	COG4249	Peptidase C14 caspase catalytic subunit p20
B446_RS19290	COG2319	Wd-40 repeat
B446_RS19325	COG0515	serine threonine protein kinase
B446_RS19350	COG0705	Rhomboid family
B446_RS19365	COG3764	Sortase (surface protein transpeptidase)
B446_RS19380	COG3764	Sortase (surface protein transpeptidase)
B446_RS19385	COG3764	Sortase (surface protein transpeptidase)
B446_RS19390	COG0515	serine threonine protein kinase
B446_RS19395	COG0768	penicillin binding
B446_RS19410	COG1716	ATPase activity
B446_RS19415	COG1716	ATPase activity
B446_RS19465	COG1250	3-hydroxyacyl-CoA dehydrogenase
B446_RS19470	COG1309	transcriptional regulator
B446_RS19475	COG1522	sequence-specific DNA binding
B446_RS19500	COG0303	'Molybdopterin
B446_RS19505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B446_RS19510	COG0604	alcohol dehydrogenase
B446_RS19525	COG0515	serine threonine protein kinase
B446_RS19530	COG0515	serine threonine protein kinase
B446_RS19535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B446_RS19545	COG0022	dehydrogenase e1 component
B446_RS19550	COG0508	dehydrogenase complex catalyzes the overall conversion of
B446_RS19575	COG2890	protein-(glutamine-N5) methyltransferase activity
B446_RS19610	COG1362	aminopeptidase activity
B446_RS19615	COG1960	acyl-CoA dehydrogenase activity
B446_RS19625	COG1741	Belongs to the pirin family
B446_RS19640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B446_RS19660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B446_RS19665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B446_RS19685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B446_RS19690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS19735	COG1957	nucleoside hydrolase
B446_RS19740	COG0366	Alpha amylase catalytic
B446_RS19805	COG0745	RESPONSE REGULATOR receiver
B446_RS19810	COG5002	protein histidine kinase activity
B446_RS19830	COG2255	four-way junction helicase activity
B446_RS19840	COG0277	FAD linked oxidase domain protein
B446_RS19900	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B446_RS19905	COG3958	Transketolase
B446_RS19910	COG3959	Transketolase, thiamine diphosphate binding domain
B446_RS19915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B446_RS19920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B446_RS19935	COG0189	ligase activity
B446_RS19945	COG3629	intracellular signal transduction
B446_RS19945	COG3903	Transcriptional regulator
B446_RS19955	COG0717	Belongs to the dCTP deaminase family
B446_RS19960	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B446_RS19975	COG2181	nitrate reductase activity
B446_RS19975	COG0247	lactate metabolic process
B446_RS19980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B446_RS19985	COG0443	Heat shock 70 kDa protein
B446_RS19990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B446_RS19995	COG0484	heat shock protein binding
B446_RS20000	COG0789	Transcriptional regulator
B446_RS20005	COG4213	ABC transporter substrate-binding protein
B446_RS20040	COG0542	response to heat
B446_RS20060	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B446_RS20080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B446_RS20090	COG0477	Major facilitator Superfamily
B446_RS20130	COG3844	kynureninase activity
B446_RS20150	COG4585	Histidine kinase
B446_RS20155	COG2197	response regulator
B446_RS20160	COG4585	Histidine kinase
B446_RS20165	COG2197	response regulator
B446_RS20180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B446_RS20190	COG0737	Belongs to the 5'-nucleotidase family
B446_RS20215	COG1802	Transcriptional regulator
B446_RS20235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B446_RS20240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B446_RS20260	COG1595	DNA-templated transcription, initiation
B446_RS20285	COG0701	Predicted permease
B446_RS20305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B446_RS20335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B446_RS20335	COG4124	Belongs to the glycosyl hydrolase 26 family
B446_RS20345	COG0726	polysaccharide deacetylase
B446_RS20405	COG1408	metallophosphoesterase
B446_RS20425	COG0003	Pfam Anion-transporting ATPase
B446_RS20450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B446_RS20480	COG0596	Alpha beta hydrolase
B446_RS20495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B446_RS20560	COG1205	dead DEAH box helicase
B446_RS20560	COG1111	helicase
B446_RS20565	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS20575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B446_RS20585	COG2264	protein methyltransferase activity
B446_RS20595	COG1754	DNA topoisomerase type I activity
B446_RS20595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B446_RS20600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B446_RS20630	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B446_RS20635	COG2133	pyrroloquinoline quinone binding
B446_RS20655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B446_RS20655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B446_RS20680	COG0346	lactoylglutathione lyase activity
B446_RS20685	COG0640	Transcriptional regulator
B446_RS20710	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS20715	COG2318	DinB family
B446_RS20720	COG0076	glutamate decarboxylase activity
B446_RS20730	COG0789	Transcriptional regulator
B446_RS20735	COG0393	Putative heavy-metal-binding
B446_RS20750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B446_RS20755	COG2027	D-alanyl-D-alanine carboxypeptidase
B446_RS20765	COG0037	tRNA processing
B446_RS20780	COG0302	gtp cyclohydrolase
B446_RS20790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B446_RS20795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B446_RS20835	COG0649	NAD binding
B446_RS20850	COG2197	response regulator
B446_RS20870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B446_RS20875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B446_RS20885	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B446_RS20905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B446_RS20930	COG0739	heme binding
B446_RS20945	COG2205	protein histidine kinase activity
B446_RS20950	COG0745	RESPONSE REGULATOR receiver
B446_RS20960	COG1595	DNA-templated transcription, initiation
B446_RS20965	COG1194	a g-specific adenine glycosylase
B446_RS20975	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B446_RS20995	COG0248	Ppx GppA phosphatase
B446_RS21000	COG1082	Xylose isomerase domain protein TIM barrel
B446_RS21010	COG0129	dihydroxy-acid dehydratase activity
B446_RS21020	COG4991	sh3 domain protein
B446_RS21035	COG1129	ABC transporter
B446_RS21035	COG0842	Transport permease protein
B446_RS21045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B446_RS21050	COG0180	Tryptophanyl-tRNA synthetase
B446_RS21070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B446_RS21085	COG0123	including yeast histone deacetylase and acetoin utilization protein
B446_RS21130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B446_RS21135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B446_RS21140	COG0181	hydroxymethylbilane synthase activity
B446_RS21145	COG1648	precorrin-2 dehydrogenase activity
B446_RS21145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B446_RS21155	COG0113	porphobilinogen synthase activity
B446_RS21160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS21185	COG0018	arginyl-trna synthetase
B446_RS21190	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B446_RS21210	COG1690	Belongs to the RtcB family
B446_RS21230	COG1742	UPF0060 membrane protein
B446_RS21235	COG1846	Transcriptional regulator
B446_RS21240	COG1733	regulation of RNA biosynthetic process
B446_RS21250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS21270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B446_RS21270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B446_RS21305	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS21310	COG1271	oxidase subunit
B446_RS21315	COG1294	oxidase, subunit
B446_RS21320	COG3387	PFAM Glycoside hydrolase 15-related
B446_RS21325	COG3265	gluconokinase activity
B446_RS21335	COG0598	Magnesium transport protein CorA
B446_RS21345	COG0745	RESPONSE REGULATOR receiver
B446_RS21375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B446_RS21380	COG0406	alpha-ribazole phosphatase activity
B446_RS21395	COG0785	Cytochrome C biogenesis protein
B446_RS21400	COG1333	cytochrome c biogenesis protein
B446_RS21405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B446_RS21435	COG0697	spore germination
B446_RS21440	COG0583	DNA-binding transcription factor activity
B446_RS21450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B446_RS21455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B446_RS21460	COG0163	prenyltransferase activity
B446_RS21470	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B446_RS21475	COG1573	uracil-dna glycosylase
B446_RS21490	COG1309	transcriptional regulator
B446_RS21510	COG3629	intracellular signal transduction
B446_RS21530	COG1278	Cold shock
B446_RS21535	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B446_RS21550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B446_RS21560	COG2226	methyltransferase
B446_RS21580	COG0242	peptide deformylase activity
B446_RS21595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21605	COG0649	NAD binding
B446_RS21615	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B446_RS21620	COG1034	ATP synthesis coupled electron transport
B446_RS21625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B446_RS21630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21640	COG0713	ATP synthesis coupled electron transport
B446_RS21645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B446_RS21655	COG1007	ATP synthesis coupled electron transport
B446_RS21665	COG0514	ATP-dependent DNA helicase (RecQ)
B446_RS21685	COG0492	ferredoxin-NADP+ reductase activity
B446_RS21690	COG0561	phosphatase activity
B446_RS21695	COG3953	SLT domain
B446_RS21695	COG5412	phage tail tape measure protein
B446_RS21700	COG0142	geranyltranstransferase activity
B446_RS21710	COG1131	(ABC) transporter
B446_RS21720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B446_RS21740	COG0702	epimerase
B446_RS21745	COG1733	regulation of RNA biosynthetic process
B446_RS21750	COG1013	pyruvate-flavodoxin oxidoreductase activity
B446_RS21755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B446_RS21755	COG0674	pyruvate-flavodoxin oxidoreductase activity
B446_RS21775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21780	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B446_RS21795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21800	COG0839	Belongs to the complex I subunit 6 family
B446_RS21805	COG0713	ATP synthesis coupled electron transport
B446_RS21815	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS21820	COG1007	ATP synthesis coupled electron transport
B446_RS21825	COG0501	Belongs to the peptidase M48B family
B446_RS21830	COG3304	Inner membrane component domain
B446_RS21840	COG2261	transglycosylase associated protein
B446_RS21845	COG1666	GTP binding
B446_RS21910	COG2188	Transcriptional regulator
B446_RS21915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B446_RS21975	COG1968	undecaprenyl-diphosphatase activity
B446_RS21995	COG0702	epimerase
B446_RS22015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B446_RS22020	COG2030	dehydratase
B446_RS22040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B446_RS22050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B446_RS22055	COG0436	Aminotransferase
B446_RS22070	COG0250	Participates in transcription elongation, termination and antitermination
B446_RS22075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B446_RS22080	COG0081	regulation of translation
B446_RS22090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B446_RS22095	COG0222	ribosome binding
B446_RS22100	COG0085	RNA polymerase activity
B446_RS22105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B446_RS22110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B446_RS22115	COG0049	tRNA binding
B446_RS22120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B446_RS22165	COG0051	transcription antitermination factor activity, RNA binding
B446_RS22170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B446_RS22175	COG0088	Forms part of the polypeptide exit tunnel
B446_RS22180	COG0089	rRNA binding
B446_RS22185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B446_RS22190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B446_RS22195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B446_RS22200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B446_RS22205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B446_RS22210	COG0255	Belongs to the universal ribosomal protein uL29 family
B446_RS22215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B446_RS22220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B446_RS22225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B446_RS22230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B446_RS22235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B446_RS22240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B446_RS22245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B446_RS22250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B446_RS22255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B446_RS22260	COG1841	ribosomal large subunit assembly
B446_RS22265	COG0200	Binds to the 23S rRNA
B446_RS22275	COG0563	adenylate kinase activity
B446_RS22285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B446_RS22290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B446_RS22295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B446_RS22300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B446_RS22305	COG0202	RNA polymerase activity
B446_RS22310	COG0203	ribosomal protein L17
B446_RS22315	COG0101	tRNA pseudouridine synthase activity
B446_RS22325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B446_RS22330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B446_RS22335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B446_RS22340	COG1072	(Pantothenic acid kinase))
B446_RS22345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B446_RS22350	COG1051	belongs to the nudix hydrolase family
B446_RS22355	COG0736	holo-[acyl-carrier-protein] synthase activity
B446_RS22365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B446_RS22375	COG0802	atpase or kinase
B446_RS22395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B446_RS22415	COG1609	Transcriptional regulator
B446_RS22420	COG1316	TRANSCRIPTIONal
B446_RS22430	COG4941	Belongs to the sigma-70 factor family
B446_RS22440	COG0726	polysaccharide deacetylase
B446_RS22445	COG0726	polysaccharide deacetylase
B446_RS22450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B446_RS22455	COG0459	protein refolding
B446_RS22465	COG4221	oxidoreductase activity
B446_RS22475	COG0583	DNA-binding transcription factor activity
B446_RS22485	COG2197	response regulator
B446_RS22495	COG1595	DNA-templated transcription, initiation
B446_RS22505	COG0516	GMP reductase activity
B446_RS22515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B446_RS22530	COG0515	serine threonine protein kinase
B446_RS22530	COG2815	serine threonine protein kinase
B446_RS22535	COG0515	serine threonine protein kinase
B446_RS22540	COG2815	serine threonine protein kinase
B446_RS22540	COG0515	serine threonine protein kinase
B446_RS22555	COG0515	serine threonine protein kinase
B446_RS22560	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS22575	COG0519	Catalyzes the synthesis of GMP from XMP
B446_RS22575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B446_RS22620	COG2197	response regulator
B446_RS22625	COG0791	NLP P60 protein
B446_RS22655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS22655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS22670	COG0714	Associated with various cellular activities
B446_RS22675	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B446_RS22680	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B446_RS22690	COG0045	succinate-CoA ligase (ADP-forming) activity
B446_RS22720	COG0138	bifunctional purine biosynthesis protein purh
B446_RS22730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B446_RS22745	COG0039	L-malate dehydrogenase activity
B446_RS22755	COG0477	Major facilitator Superfamily
B446_RS22765	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS22775	COG4175	Glycine betaine
B446_RS22775	COG0517	IMP dehydrogenase activity
B446_RS22795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B446_RS22800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B446_RS22805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS22820	COG0754	glutathionylspermidine amidase activity
B446_RS22825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B446_RS22830	COG0180	Tryptophanyl-tRNA synthetase
B446_RS22845	COG1295	ribonuclease BN
B446_RS22860	COG1408	metallophosphoesterase
B446_RS22865	COG0747	negative chemotaxis
B446_RS22870	COG1309	transcriptional regulator
B446_RS22895	COG1053	succinate dehydrogenase
B446_RS22905	COG2009	succinate dehydrogenase
B446_RS22955	COG1595	DNA-templated transcription, initiation
B446_RS22970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS22970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS23000	COG1216	Glycosyl transferase, family 2
B446_RS23015	COG2089	acid synthase
B446_RS23025	COG1473	amidohydrolase
B446_RS23025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B446_RS23030	COG1744	ABC transporter substrate-binding protein PnrA-like
B446_RS23035	COG1744	ABC transporter substrate-binding protein PnrA-like
B446_RS23040	COG3845	ABC transporter
B446_RS23045	COG4603	Belongs to the binding-protein-dependent transport system permease family
B446_RS23050	COG1079	Belongs to the binding-protein-dependent transport system permease family
B446_RS23080	COG2814	Major facilitator Superfamily
B446_RS23085	COG0583	DNA-binding transcription factor activity
B446_RS23100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B446_RS23125	COG2205	protein histidine kinase activity
B446_RS23130	COG0745	RESPONSE REGULATOR receiver
B446_RS23135	COG1595	DNA-templated transcription, initiation
B446_RS23150	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS23155	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS23160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B446_RS23170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B446_RS23190	COG1349	DNA-binding transcription factor activity
B446_RS23195	COG4770	biotin carboxylase activity
B446_RS23205	COG0424	maF-like protein
B446_RS23215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B446_RS23225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B446_RS23235	COG1024	Enoyl-CoA hydratase
B446_RS23245	COG2986	histidine ammonia-lyase
B446_RS23270	COG0577	efflux transmembrane transporter activity
B446_RS23270	COG1136	(ABC) transporter
B446_RS23275	COG1404	Belongs to the peptidase S8 family
B446_RS23285	COG1064	alcohol dehydrogenase
B446_RS23325	COG1595	DNA-templated transcription, initiation
B446_RS23330	COG2255	four-way junction helicase activity
B446_RS23335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B446_RS23350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B446_RS23360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B446_RS23385	COG1331	Highly conserved protein containing a thioredoxin domain
B446_RS23415	COG1309	transcriptional regulator
B446_RS23425	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B446_RS23435	COG0436	Aminotransferase
B446_RS23450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B446_RS23465	COG1414	Transcriptional regulator
B446_RS23470	COG0251	oxidation-reduction process
B446_RS23475	COG2610	gluconate transmembrane transporter activity
B446_RS23510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B446_RS23545	COG2894	cell division
B446_RS23575	COG4585	Histidine kinase
B446_RS23580	COG2197	response regulator
B446_RS23600	COG2885	chlorophyll binding
B446_RS23615	COG2318	DinB family
B446_RS23620	COG2226	methyltransferase
B446_RS23625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B446_RS23630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B446_RS23635	COG0741	lytic transglycosylase activity
B446_RS23645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B446_RS23650	COG0450	alkyl hydroperoxide reductase
B446_RS23665	COG1136	(ABC) transporter
B446_RS23685	COG4499	WXG100 protein secretion system (Wss), protein YukC
B446_RS23685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B446_RS23695	COG3557	Belongs to the UPF0374 family
B446_RS23700	COG0114	fumarate hydratase activity
B446_RS23715	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B446_RS23715	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B446_RS23740	COG0778	Nitroreductase
B446_RS23745	COG1722	exodeoxyribonuclease VII activity
B446_RS23750	COG1570	exodeoxyribonuclease VII activity
B446_RS23760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B446_RS23775	COG0012	GTP binding
B446_RS23795	COG3903	Transcriptional regulator
B446_RS23795	COG3629	intracellular signal transduction
B446_RS23810	COG0512	Glutamine amidotransferase of anthranilate synthase
B446_RS23820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B446_RS23825	COG0475	glutathione-regulated potassium exporter activity
B446_RS23840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B446_RS23845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS23860	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS23875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B446_RS23895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B446_RS23960	COG1136	(ABC) transporter
B446_RS23960	COG0577	efflux transmembrane transporter activity
B446_RS23970	COG2175	clavaminate synthase activity
B446_RS23990	COG3629	intracellular signal transduction
B446_RS23990	COG3903	Transcriptional regulator
B446_RS23995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B446_RS24050	COG1053	succinate dehydrogenase
B446_RS24070	COG1217	gtp-binding protein TYPA
B446_RS24075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B446_RS24080	COG4166	transmembrane transport
B446_RS24085	COG0601	transmembrane transport
B446_RS24090	COG0444	Belongs to the ABC transporter superfamily
B446_RS24095	COG4608	Belongs to the ABC transporter superfamily
B446_RS24120	COG3903	Transcriptional regulator
B446_RS24120	COG3629	intracellular signal transduction
B446_RS24130	COG4608	Belongs to the ABC transporter superfamily
B446_RS24135	COG0444	Belongs to the ABC transporter superfamily
B446_RS24140	COG0601	transmembrane transport
B446_RS24145	COG4166	transmembrane transport
B446_RS24150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B446_RS24155	COG4166	transmembrane transport
B446_RS24160	COG0601	transmembrane transport
B446_RS24165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B446_RS24170	COG0444	Belongs to the ABC transporter superfamily
B446_RS24175	COG4608	Belongs to the ABC transporter superfamily
B446_RS24190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B446_RS24205	COG1131	(ABC) transporter
B446_RS24215	COG4585	Histidine kinase
B446_RS24220	COG2197	response regulator
B446_RS24255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B446_RS24265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B446_RS24275	COG0519	Catalyzes the synthesis of GMP from XMP
B446_RS24280	COG1024	Enoyl-CoA hydratase
B446_RS24290	COG1595	DNA-templated transcription, initiation
B446_RS24300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B446_RS24305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B446_RS24345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B446_RS24355	COG0598	Magnesium transport protein CorA
B446_RS24365	COG2814	Major facilitator Superfamily
B446_RS24380	COG2095	MarC family integral membrane protein
B446_RS24385	COG1432	Conserved Protein
B446_RS24395	COG0513	Belongs to the DEAD box helicase family
B446_RS24435	COG0747	negative chemotaxis
B446_RS24440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B446_RS24505	COG0210	DNA helicase
B446_RS24510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B446_RS24515	COG2816	NAD+ diphosphatase activity
B446_RS24540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B446_RS24590	COG3480	Lon protease (S16) C-terminal proteolytic domain
B446_RS24600	COG1615	UPF0182 protein
B446_RS24625	COG0753	catalase activity
B446_RS24640	COG0483	inositol monophosphate 1-phosphatase activity
B446_RS24650	COG2076	Multidrug Resistance protein
B446_RS24660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B446_RS24670	COG2135	peptidase activity
B446_RS24680	COG1595	DNA-templated transcription, initiation
B446_RS24685	COG5662	AntiSigma factor
B446_RS24690	COG2199	diguanylate cyclase activity
B446_RS24690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B446_RS24705	COG0242	peptide deformylase activity
B446_RS24715	COG2124	cytochrome p450
B446_RS24745	COG2188	Transcriptional regulator
B446_RS24750	COG0363	glucosamine-6-phosphate deaminase activity
B446_RS24765	COG1597	lipid kinase activity
B446_RS24795	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B446_RS24805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B446_RS24810	COG0142	geranyltranstransferase activity
B446_RS24865	COG4106	trans-aconitate 2-methyltransferase activity
B446_RS24870	COG1126	abc transporter atp-binding protein
B446_RS24885	COG0281	malic enzyme
B446_RS24890	COG0604	alcohol dehydrogenase
B446_RS24920	COG2255	four-way junction helicase activity
B446_RS24945	COG0567	Dehydrogenase, E1 component
B446_RS24945	COG0508	dehydrogenase complex catalyzes the overall conversion of
B446_RS24950	COG2205	protein histidine kinase activity
B446_RS24955	COG0745	RESPONSE REGULATOR receiver
B446_RS24970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B446_RS25025	COG0791	NLP P60 protein
B446_RS25025	COG1388	LysM domain
B446_RS25025	COG3103	Sh3 type 3 domain protein
B446_RS25055	COG0768	penicillin binding
B446_RS25065	COG2205	protein histidine kinase activity
B446_RS25085	COG3285	dna ligase
B446_RS25085	COG1793	dna ligase
B446_RS25090	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B446_RS25100	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B446_RS25185	COG0745	RESPONSE REGULATOR receiver
B446_RS25190	COG0018	arginyl-trna synthetase
B446_RS25195	COG0019	diaminopimelate decarboxylase activity
B446_RS25200	COG0460	homoserine dehydrogenase
B446_RS25205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B446_RS25210	COG0083	homoserine kinase activity
B446_RS25225	COG0254	rRNA binding
B446_RS25230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B446_RS25235	COG2890	protein-(glutamine-N5) methyltransferase activity
B446_RS25245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B446_RS25250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B446_RS25255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B446_RS25275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B446_RS25280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B446_RS25285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B446_RS25290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B446_RS25295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B446_RS25300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B446_RS25305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B446_RS25320	COG0745	RESPONSE REGULATOR receiver
B446_RS25345	COG1250	3-hydroxyacyl-CoA dehydrogenase
B446_RS25360	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B446_RS25395	COG1131	(ABC) transporter
B446_RS25415	COG0183	Belongs to the thiolase family
B446_RS25485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS25485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS25520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B446_RS25525	COG0280	phosphate acetyltransferase
B446_RS25525	COG0857	belongs to the CobB CobQ family
B446_RS25530	COG0205	6-phosphofructokinase activity
B446_RS25540	COG4565	transcriptional regulatory protein
B446_RS25545	COG3290	protein histidine kinase activity
B446_RS25550	COG1301	dicarboxylic acid transport
B446_RS25560	COG0477	Major facilitator Superfamily
B446_RS25585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B446_RS25590	COG3281	Trehalose synthase
B446_RS25600	COG0366	Alpha amylase catalytic
B446_RS25605	COG0058	SHG alpha-glucan phosphorylase activity
B446_RS25625	COG1132	(ABC) transporter
B446_RS25635	COG1132	(ABC) transporter
B446_RS25640	COG1132	(ABC) transporter
B446_RS25675	COG1376	ErfK ybiS ycfS ynhG family protein
B446_RS25680	COG1376	ErfK ybiS ycfS ynhG family protein
B446_RS25725	COG1760	l-serine dehydratase
B446_RS25730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B446_RS25735	COG0509	glycine decarboxylation via glycine cleavage system
B446_RS25740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B446_RS25760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B446_RS25765	COG0747	negative chemotaxis
B446_RS25770	COG0601	transmembrane transport
B446_RS25775	COG0444	Belongs to the ABC transporter superfamily
B446_RS25780	COG4608	Belongs to the ABC transporter superfamily
B446_RS25790	COG2860	membrane
B446_RS25810	COG2378	regulation of single-species biofilm formation
B446_RS25840	COG0482	sulfurtransferase activity
B446_RS25855	COG1611	Belongs to the LOG family
B446_RS25860	COG4221	oxidoreductase activity
B446_RS25870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B446_RS25885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B446_RS25890	COG0154	amidase activity
B446_RS25900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B446_RS25920	COG2197	response regulator
B446_RS25930	COG2133	pyrroloquinoline quinone binding
B446_RS25935	COG0667	Aldo Keto reductase
B446_RS25955	COG0440	acetolactate synthase activity
B446_RS25960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B446_RS25965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B446_RS25970	COG0477	Major facilitator Superfamily
B446_RS25980	COG2508	Transcriptional regulator
B446_RS25985	COG0506	proline dehydrogenase activity
B446_RS25990	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS26000	COG0473	3-isopropylmalate dehydrogenase activity
B446_RS26005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B446_RS26015	COG0832	Belongs to the urease beta subunit family
B446_RS26015	COG0831	urea catabolic process
B446_RS26020	COG0804	urea catabolic process
B446_RS26025	COG2957	Belongs to the agmatine deiminase family
B446_RS26035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B446_RS26075	COG5492	domain, Protein
B446_RS26080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B446_RS26100	COG2018	Roadblock/LC7 domain
B446_RS26120	COG2018	Roadblock/LC7 domain
B446_RS26125	COG5002	protein histidine kinase activity
B446_RS26140	COG0179	Fumarylacetoacetate (FAA) hydrolase
B446_RS26145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B446_RS26180	COG1414	Transcriptional regulator
B446_RS26185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B446_RS26190	COG0066	3-isopropylmalate dehydratase activity
B446_RS26200	COG0776	regulation of translation
B446_RS26210	COG1920	GTP binding
B446_RS26220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B446_RS26225	COG1181	Belongs to the D-alanine--D-alanine ligase family
B446_RS26245	COG0351	phosphomethylpyrimidine kinase
B446_RS26250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B446_RS26255	COG1461	Dihydroxyacetone kinase
B446_RS26265	COG0326	Molecular chaperone. Has ATPase activity
B446_RS26275	COG0742	ribosomal rna small subunit methyltransferase
B446_RS26280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B446_RS26295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B446_RS26300	COG0571	ribonuclease III activity
B446_RS26305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B446_RS26310	COG1733	regulation of RNA biosynthetic process
B446_RS26330	COG2340	Cysteine-rich secretory protein family
B446_RS26335	COG1254	Belongs to the acylphosphatase family
B446_RS26345	COG1196	nuclear chromosome segregation
B446_RS26350	COG0477	Major facilitator Superfamily
B446_RS26390	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B446_RS26400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B446_RS26405	COG4106	trans-aconitate 2-methyltransferase activity
B446_RS26415	COG0228	four-way junction DNA binding
B446_RS26420	COG1837	Belongs to the UPF0109 family
B446_RS26425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B446_RS26430	COG0336	Belongs to the RNA methyltransferase TrmD family
B446_RS26435	COG0335	large ribosomal subunit rRNA binding
B446_RS26455	COG1051	belongs to the nudix hydrolase family
B446_RS26465	COG0792	nuclease activity
B446_RS26480	COG1191	sigma factor activity
B446_RS26495	COG0052	Belongs to the universal ribosomal protein uS2 family
B446_RS26500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B446_RS26505	COG0528	UMP kinase activity
B446_RS26510	COG0233	cytoplasmic translational termination
B446_RS26515	COG0575	Belongs to the CDS family
B446_RS26530	COG2353	YceI-like domain
B446_RS26555	COG3903	Transcriptional regulator
B446_RS26555	COG3629	intracellular signal transduction
B446_RS26565	COG3903	Transcriptional regulator
B446_RS26565	COG3629	intracellular signal transduction
B446_RS26570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B446_RS26580	COG4208	sulfate ABC transporter
B446_RS26585	COG3842	ATPase activity
B446_RS26620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B446_RS26630	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS26660	COG0584	glycerophosphoryl diester phosphodiesterase
B446_RS26665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B446_RS26690	COG3842	ATPase activity
B446_RS26695	COG1176	ABC-type spermidine putrescine transport system, permease component I
B446_RS26700	COG1177	transmembrane transport
B446_RS26705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B446_RS26735	COG2508	Transcriptional regulator
B446_RS26740	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS26755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B446_RS26760	COG0750	zinc metalloprotease
B446_RS26765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B446_RS26780	COG0442	prolyl-tRNA aminoacylation
B446_RS26800	COG0779	Required for maturation of 30S ribosomal subunits
B446_RS26815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B446_RS26825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B446_RS26830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B446_RS26845	COG0455	bacterial-type flagellum organization
B446_RS26865	COG1404	Belongs to the peptidase S8 family
B446_RS26915	COG0515	serine threonine protein kinase
B446_RS26915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B446_RS26920	COG0515	serine threonine protein kinase
B446_RS26920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B446_RS26925	COG1674	ftsk spoiiie
B446_RS26940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B446_RS26945	COG1185	polyribonucleotide nucleotidyltransferase activity
B446_RS26950	COG0612	Peptidase, M16
B446_RS26955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B446_RS26975	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B446_RS26980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B446_RS26985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B446_RS27015	COG2770	Histidine kinase
B446_RS27015	COG2208	phosphoserine phosphatase activity
B446_RS27020	COG0784	Response regulator, receiver
B446_RS27020	COG2205	protein histidine kinase activity
B446_RS27030	COG1674	ftsk spoiiie
B446_RS27040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B446_RS27050	COG1058	Belongs to the CinA family
B446_RS27050	COG1546	Belongs to the CinA family
B446_RS27055	COG1396	sequence-specific DNA binding
B446_RS27060	COG0783	Belongs to the Dps family
B446_RS27065	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS27070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B446_RS27075	COG1201	RNA secondary structure unwinding
B446_RS27080	COG2207	Transcriptional regulator
B446_RS27105	COG0628	permease
B446_RS27115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B446_RS27130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B446_RS27145	COG0765	amino acid transport
B446_RS27150	COG0765	amino acid transport
B446_RS27155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B446_RS27160	COG1126	abc transporter atp-binding protein
B446_RS27165	COG0745	RESPONSE REGULATOR receiver
B446_RS27170	COG2205	protein histidine kinase activity
B446_RS27210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B446_RS27230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B446_RS27240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B446_RS27245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B446_RS27255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B446_RS27285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B446_RS27290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B446_RS27295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B446_RS27310	COG0588	phosphoglycerate mutase activity
B446_RS27325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B446_RS27365	COG1802	Transcriptional regulator
B446_RS27370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B446_RS27385	COG0187	DNA topoisomerase II activity
B446_RS27400	COG2197	response regulator
B446_RS27410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS27425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B446_RS27435	COG4565	transcriptional regulatory protein
B446_RS27440	COG3290	protein histidine kinase activity
B446_RS27455	COG0372	Belongs to the citrate synthase family
B446_RS27465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B446_RS27470	COG0612	Peptidase, M16
B446_RS27485	COG1802	Transcriptional regulator
B446_RS27490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B446_RS27510	COG1435	thymidine kinase activity
B446_RS27545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B446_RS27555	COG0745	RESPONSE REGULATOR receiver
B446_RS27560	COG2205	protein histidine kinase activity
B446_RS27585	COG0756	dUTP diphosphatase activity
B446_RS27620	COG0569	domain protein
B446_RS27625	COG0531	amino acid
B446_RS27630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B446_RS27710	COG0252	asparaginase activity
B446_RS27745	COG0477	Major facilitator Superfamily
B446_RS27755	COG4585	Histidine kinase
B446_RS27760	COG2197	response regulator
B446_RS27815	COG1799	cell septum assembly
B446_RS27855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B446_RS27875	COG2235	arginine
B446_RS27880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B446_RS27885	COG0531	amino acid
B446_RS27895	COG1902	pentaerythritol trinitrate reductase activity
B446_RS27930	COG1024	Enoyl-CoA hydratase
B446_RS27975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B446_RS27985	COG3629	intracellular signal transduction
B446_RS28015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B446_RS28025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B446_RS28030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS28035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B446_RS28060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B446_RS28070	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS28100	COG0477	Major facilitator Superfamily
B446_RS28115	COG0477	Major facilitator Superfamily
B446_RS28125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B446_RS28155	COG2188	Transcriptional regulator
B446_RS28160	COG2182	Extracellular solute-binding protein
B446_RS28165	COG1175	transmembrane transport
B446_RS28170	COG0395	ABC-type sugar transport system, permease component
B446_RS28175	COG1472	Belongs to the glycosyl hydrolase 3 family
B446_RS28215	COG0730	response to heat
B446_RS28220	COG1937	Protein conserved in bacteria
B446_RS28240	COG3290	protein histidine kinase activity
B446_RS28245	COG1116	anion transmembrane transporter activity
B446_RS28250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B446_RS28270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B446_RS28275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B446_RS28280	COG3290	protein histidine kinase activity
B446_RS28285	COG3537	Alpha-1,2-mannosidase
B446_RS28295	COG1653	transport
B446_RS28300	COG1175	transmembrane transport
B446_RS28305	COG0395	ABC-type sugar transport system, permease component
B446_RS28310	COG1940	carbohydrate kinase activity
B446_RS28315	COG4213	ABC transporter substrate-binding protein
B446_RS28325	COG4214	carbohydrate transport
B446_RS28330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B446_RS28335	COG0531	amino acid
B446_RS28360	COG1250	3-hydroxyacyl-CoA dehydrogenase
B446_RS28360	COG1024	Enoyl-CoA hydratase
B446_RS28365	COG0183	Belongs to the thiolase family
B446_RS28385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B446_RS28400	COG0446	pyridine nucleotide-disulphide oxidoreductase
B446_RS28405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B446_RS28410	COG3253	May function as heme-dependent peroxidase
B446_RS28415	COG0596	Alpha beta hydrolase
B446_RS28430	COG3220	belongs to the UPF0276 family
B446_RS28460	COG1881	PFAM PEBP family protein
B446_RS28465	COG0330	HflC and HflK could
B446_RS28495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B446_RS28500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B446_RS28515	COG1174	glycine betaine transport
B446_RS28535	COG2018	Roadblock/LC7 domain
B446_RS28550	COG0640	Transcriptional regulator
B446_RS28590	COG1309	transcriptional regulator
B446_RS28625	COG3173	Aminoglycoside phosphotransferase
B446_RS28690	COG2409	Drug exporters of the RND superfamily
B446_RS28700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B446_RS28750	COG2124	cytochrome p450
B446_RS28755	COG2124	cytochrome p450
B446_RS28765	COG0142	geranyltranstransferase activity
B446_RS28780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B446_RS28785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B446_RS28785	COG1116	anion transmembrane transporter activity
B446_RS28810	COG0529	Catalyzes the synthesis of activated sulfate
B446_RS28815	COG0175	sulfate reduction
B446_RS28825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B446_RS28845	COG1960	acyl-CoA dehydrogenase activity
B446_RS28855	COG4977	sequence-specific DNA binding
B446_RS28855	COG1917	Cupin 2, conserved barrel domain protein
B446_RS28895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B446_RS28910	COG0697	spore germination
B446_RS28925	COG2040	homocysteine
B446_RS28960	COG1940	carbohydrate kinase activity
B446_RS28965	COG0277	FAD linked oxidase domain protein
B446_RS28985	COG1162	GTPase activity
B446_RS29025	COG0028	Belongs to the TPP enzyme family
B446_RS29045	COG1802	Transcriptional regulator
B446_RS29075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B446_RS29080	COG2252	PERMEase
B446_RS29095	COG0726	polysaccharide deacetylase
B446_RS29130	COG1653	transport
B446_RS29140	COG2843	Capsule synthesis protein
B446_RS29150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B446_RS29175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B446_RS29180	COG2326	polyphosphate kinase activity
B446_RS29185	COG0583	DNA-binding transcription factor activity
B446_RS29205	COG2197	response regulator
B446_RS29210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B446_RS29215	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS29225	COG3960	tartronate-semialdehyde synthase activity
B446_RS29240	COG0753	catalase activity
B446_RS29245	COG2084	Dehydrogenase
B446_RS29250	COG3622	Belongs to the hyi family
B446_RS29270	COG2351	hydroxyisourate hydrolase activity
B446_RS29285	COG2233	PERMEase
B446_RS29290	COG3548	integral membrane protein
B446_RS29315	COG1733	regulation of RNA biosynthetic process
B446_RS29330	COG4264	IucA IucC family
B446_RS29340	COG0784	Response regulator, receiver
B446_RS29350	COG4251	negative regulation of phosphorylation
B446_RS29360	COG1295	ribonuclease BN
B446_RS29370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B446_RS29385	COG1414	Transcriptional regulator
B446_RS29390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B446_RS29395	COG4266	Belongs to the allantoicase family
B446_RS29400	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS29430	COG0673	inositol 2-dehydrogenase activity
B446_RS29435	COG2188	Transcriptional regulator
B446_RS29455	COG1940	carbohydrate kinase activity
B446_RS29465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B446_RS29475	COG1278	Cold shock
B446_RS29485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B446_RS29505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B446_RS29510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B446_RS29535	COG0405	Gamma-glutamyltransferase
B446_RS29540	COG0542	response to heat
B446_RS29565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B446_RS29580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B446_RS29590	COG1953	Uracil, thiamine, allantoin
B446_RS29630	COG0483	inositol monophosphate 1-phosphatase activity
B446_RS29640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B446_RS29695	COG3387	PFAM Glycoside hydrolase 15-related
B446_RS29700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B446_RS29740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B446_RS29760	COG5285	phytanoyl-CoA dioxygenase
B446_RS29765	COG0477	Major facilitator Superfamily
B446_RS29775	COG2072	flavoprotein involved in K transport
B446_RS29780	COG2175	clavaminate synthase activity
B446_RS29795	COG2124	cytochrome p450
B446_RS29800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B446_RS29805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B446_RS29810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B446_RS29830	COG1929	Belongs to the glycerate kinase type-1 family
B446_RS29840	COG0688	phosphatidylethanolamine metabolic process
B446_RS29845	COG1960	acyl-CoA dehydrogenase activity
B446_RS29855	COG2301	Belongs to the HpcH HpaI aldolase family
B446_RS29860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS29860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B446_RS29865	COG0604	alcohol dehydrogenase
B446_RS29875	COG1250	3-hydroxyacyl-CoA dehydrogenase
B446_RS29885	COG0456	acetyltransferase
B446_RS29920	COG2362	D-Aminopeptidase
B446_RS29925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B446_RS29935	COG1619	proteins homologs of microcin C7 resistance protein MccF
B446_RS29945	COG3396	Phenylacetate-CoA oxygenase
B446_RS29950	COG3460	Phenylacetate-CoA oxygenase
B446_RS29955	COG3396	Phenylacetate-CoA oxygenase
B446_RS29960	COG2151	metal-sulfur cluster biosynthetic enzyme
B446_RS29965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B446_RS29985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS30055	COG2226	methyltransferase
B446_RS30070	COG0488	(ABC) transporter
B446_RS30095	COG0028	Belongs to the TPP enzyme family
B446_RS30120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B446_RS30150	COG0443	Heat shock 70 kDa protein
B446_RS30175	COG2154	pterin-4-alpha-carbinolamine dehydratase
B446_RS30180	COG2226	methyltransferase
B446_RS30185	COG5297	Belongs to the glycosyl hydrolase family 6
B446_RS30185	COG4733	cellulase activity
B446_RS30195	COG5297	Belongs to the glycosyl hydrolase family 6
B446_RS30200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B446_RS30205	COG4221	oxidoreductase activity
B446_RS30245	COG1335	isochorismatase
B446_RS30250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B446_RS30255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B446_RS30265	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS30290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B446_RS30305	COG1940	carbohydrate kinase activity
B446_RS30310	COG2182	Extracellular solute-binding protein
B446_RS30315	COG1175	transmembrane transport
B446_RS30320	COG0395	ABC-type sugar transport system, permease component
B446_RS30325	COG2723	6-phospho-beta-galactosidase activity
B446_RS30330	COG2273	Hydrolase Family 16
B446_RS30395	COG1183	phosphatidylcholine synthase activity
B446_RS30410	COG0297	glycogen (starch) synthase activity
B446_RS30425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B446_RS30450	COG1595	DNA-templated transcription, initiation
B446_RS30460	COG0477	Major facilitator Superfamily
B446_RS30470	COG3467	pyridoxamine 5'-phosphate
B446_RS30495	COG0406	alpha-ribazole phosphatase activity
B446_RS30500	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B446_RS30505	COG0166	Belongs to the GPI family
B446_RS30520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B446_RS30540	COG3739	integral membrane protein
B446_RS30545	COG1486	melibiose metabolic process
B446_RS30550	COG3469	chitinase activity
B446_RS30560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B446_RS30600	COG1175	transmembrane transport
B446_RS30605	COG0395	ABC-type sugar transport system, permease component
B446_RS30610	COG0366	Alpha amylase catalytic
B446_RS30620	COG3511	phospholipase C
B446_RS30650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B446_RS30665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B446_RS30670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B446_RS30675	COG3485	protocatechuate 3,4-dioxygenase
B446_RS30680	COG3485	protocatechuate 3,4-dioxygenase
B446_RS30695	COG1846	Transcriptional regulator
B446_RS30710	COG1793	dna ligase
B446_RS30745	COG1834	amidinotransferase
B446_RS30750	COG0488	(ABC) transporter
B446_RS30775	COG1515	deoxyribonuclease V activity
B446_RS30785	COG3268	Saccharopine dehydrogenase
B446_RS30790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B446_RS30795	COG0183	Belongs to the thiolase family
B446_RS30800	COG1024	Enoyl-CoA hydratase
B446_RS30800	COG1250	3-hydroxyacyl-CoA dehydrogenase
B446_RS30805	COG0789	Transcriptional regulator
B446_RS30810	COG1113	amino acid transport
B446_RS30820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B446_RS30830	COG2936	dipeptidyl-peptidase activity
B446_RS30840	COG0488	(ABC) transporter
B446_RS30845	COG2183	response to ionizing radiation
B446_RS30850	COG4977	sequence-specific DNA binding
B446_RS30860	COG1024	Enoyl-CoA hydratase
B446_RS30870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B446_RS30915	COG1134	teichoic acid transport
B446_RS30920	COG1562	ergosterol biosynthetic process
B446_RS30930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B446_RS30940	COG1657	PFAM Prenyltransferase squalene oxidase
B446_RS30955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B446_RS30990	COG4942	peptidase
B446_RS31040	COG1063	alcohol dehydrogenase
B446_RS31045	COG0156	8-amino-7-oxononanoate synthase activity
B446_RS31050	COG0583	DNA-binding transcription factor activity
B446_RS31055	COG1396	sequence-specific DNA binding
B446_RS31115	COG0561	phosphatase activity
B446_RS31130	COG2267	carboxylic ester hydrolase activity
B446_RS31135	COG0183	Belongs to the thiolase family
B446_RS31140	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS31225	COG0531	amino acid
B446_RS31230	COG0395	ABC-type sugar transport system, permease component
B446_RS31240	COG1653	transport
B446_RS31265	COG0673	inositol 2-dehydrogenase activity
B446_RS31270	COG0673	inositol 2-dehydrogenase activity
B446_RS31305	COG2837	iron assimilation
B446_RS31315	COG3938	Belongs to the proline racemase family
B446_RS31320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B446_RS31335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B446_RS31345	COG2197	response regulator
B446_RS31370	COG2124	cytochrome p450
B446_RS31380	COG2838	Isocitrate dehydrogenase
B446_RS31395	COG0668	transmembrane transport
B446_RS31400	COG1024	Enoyl-CoA hydratase
B446_RS31410	COG1132	(ABC) transporter
B446_RS31420	COG2080	2 iron, 2 sulfur cluster binding
B446_RS31425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B446_RS31430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B446_RS31450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS31455	COG3275	phosphorelay sensor kinase activity
B446_RS31485	COG1414	Transcriptional regulator
B446_RS31490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B446_RS31520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B446_RS31525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B446_RS31535	COG0028	Belongs to the TPP enzyme family
B446_RS31545	COG1278	Cold shock
B446_RS31550	COG0513	Belongs to the DEAD box helicase family
B446_RS31555	COG0513	Belongs to the DEAD box helicase family
B446_RS31565	COG2268	Band 7 protein
B446_RS31580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B446_RS31605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B446_RS31620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B446_RS31660	COG0702	epimerase
B446_RS31665	COG1271	oxidase subunit
B446_RS31690	COG1012	belongs to the aldehyde dehydrogenase family
B446_RS31700	COG0583	DNA-binding transcription factor activity
B446_RS31710	COG0656	L-ascorbic acid biosynthetic process
B446_RS31715	COG0431	NADPH-dependent FMN reductase
B446_RS31720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS31735	COG0693	protein deglycase activity
B446_RS31740	COG0443	Heat shock 70 kDa protein
B446_RS31745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B446_RS31760	COG0542	response to heat
B446_RS31785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B446_RS31790	COG1116	anion transmembrane transporter activity
B446_RS31800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS31805	COG0583	DNA-binding transcription factor activity
B446_RS31815	COG0431	NADPH-dependent FMN reductase
B446_RS31825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS31830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B446_RS31840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B446_RS31860	COG0297	glycogen (starch) synthase activity
B446_RS31865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B446_RS31870	COG3537	Alpha-1,2-mannosidase
B446_RS31885	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS31890	COG0154	amidase activity
B446_RS31900	COG1653	transport
B446_RS31905	COG1175	transmembrane transport
B446_RS31945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B446_RS31970	COG0531	amino acid
B446_RS31990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B446_RS31990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B446_RS31995	COG0726	polysaccharide deacetylase
B446_RS32045	COG1053	succinate dehydrogenase
B446_RS32050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B446_RS32075	COG0542	response to heat
B446_RS32080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B446_RS32095	COG3360	Dodecin
B446_RS32105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B446_RS32110	COG0121	glutamine amidotransferase
B446_RS32115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B446_RS32135	COG2268	Band 7 protein
B446_RS32185	COG1609	Transcriptional regulator
B446_RS32190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B446_RS32200	COG0242	peptide deformylase activity
B446_RS32220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B446_RS32220	COG0574	Belongs to the PEP-utilizing enzyme family
B446_RS32225	COG0151	Belongs to the GarS family
B446_RS32235	COG0640	Transcriptional regulator
B446_RS32280	COG0583	DNA-binding transcription factor activity
B446_RS32310	COG0542	response to heat
B446_RS32320	COG1174	glycine betaine transport
B446_RS32325	COG1174	glycine betaine transport
B446_RS32340	COG1556	Lactate utilization protein
B446_RS32345	COG1139	Iron-sulfur cluster binding protein
B446_RS32350	COG0247	lactate metabolic process
B446_RS32355	COG1070	Carbohydrate kinase
B446_RS32360	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS32360	COG3347	Dehydrogenase
B446_RS32370	COG1129	ABC transporter
B446_RS32375	COG1172	Belongs to the binding-protein-dependent transport system permease family
B446_RS32380	COG1172	Belongs to the binding-protein-dependent transport system permease family
B446_RS32390	COG1609	Transcriptional regulator
B446_RS32400	COG1595	DNA-templated transcription, initiation
B446_RS32405	COG1357	PFAM Pentapeptide repeats (8 copies)
B446_RS32415	COG1309	transcriptional regulator
B446_RS32425	COG2706	6-phosphogluconolactonase activity
B446_RS32445	COG1940	carbohydrate kinase activity
B446_RS32460	COG0546	phosphoglycolate phosphatase activity
B446_RS32465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B446_RS32465	COG1796	DNA polymerase
B446_RS32470	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS32515	COG1006	Multisubunit Na H antiporter MnhC subunit
B446_RS32520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B446_RS32535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B446_RS32540	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS32565	COG0531	amino acid
B446_RS32590	COG0435	Glutathione S-transferase
B446_RS32615	COG2124	cytochrome p450
B446_RS32635	COG0667	Aldo Keto reductase
B446_RS32670	COG1595	DNA-templated transcription, initiation
B446_RS32680	COG2132	Multicopper oxidase
B446_RS32720	COG2890	protein-(glutamine-N5) methyltransferase activity
B446_RS32785	COG2124	cytochrome p450
B446_RS32805	COG3251	PFAM MbtH domain protein
B446_RS32825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B446_RS32835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B446_RS32870	COG0277	FAD linked oxidase domain protein
B446_RS32870	COG0247	lactate metabolic process
B446_RS32875	COG4221	oxidoreductase activity
B446_RS32935	COG2326	polyphosphate kinase activity
B446_RS32960	COG3608	succinylglutamate desuccinylase aspartoacylase
B446_RS32960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B446_RS33020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B446_RS33045	COG0583	DNA-binding transcription factor activity
B446_RS33065	COG0326	Molecular chaperone. Has ATPase activity
B446_RS33175	COG0477	Major facilitator Superfamily
B446_RS33185	COG0456	acetyltransferase
B446_RS33200	COG0456	acetyltransferase
B446_RS33205	COG0477	Major facilitator Superfamily
B446_RS33210	COG4585	Histidine kinase
B446_RS33215	COG2197	response regulator
B446_RS33225	COG2272	Belongs to the type-B carboxylesterase lipase family
B446_RS33240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B446_RS33255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B446_RS33275	COG0069	glutamate synthase activity
B446_RS33280	COG0028	Belongs to the TPP enzyme family
B446_RS33370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B446_RS33395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B446_RS33450	COG2211	Major facilitator Superfamily
B446_RS33510	COG1247	-acetyltransferase
B446_RS33550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B446_RS33585	COG0572	uridine kinase
B446_RS33610	COG3246	L-lysine catabolic process to acetate
B446_RS33620	COG2175	clavaminate synthase activity
B446_RS33635	COG1733	regulation of RNA biosynthetic process
B446_RS33665	COG1086	Polysaccharide biosynthesis protein
B446_RS33690	COG2318	DinB family
B446_RS33700	COG0300	oxidoreductase activity
B446_RS33700	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS33700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33700	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS33700	COG3321	synthase
B446_RS33705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33705	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS33705	COG3321	synthase
B446_RS33705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS33705	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS33705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS33705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS33705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS33705	COG3321	synthase
B446_RS33710	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS33710	COG3321	synthase
B446_RS33710	COG0318	PFAM AMP-dependent synthetase and ligase
B446_RS33710	COG0300	oxidoreductase activity
B446_RS33710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33715	COG3321	synthase
B446_RS33715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS33715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B446_RS33715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33715	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS33720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS33720	COG0300	oxidoreductase activity
B446_RS33720	COG3321	synthase
B446_RS33720	COG4221	oxidoreductase activity
B446_RS33725	COG3321	synthase
B446_RS33725	COG0604	alcohol dehydrogenase
B446_RS33735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33740	COG2070	2-Nitropropane dioxygenase
B446_RS33740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B446_RS33750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B446_RS33755	COG2226	methyltransferase
B446_RS33760	COG0604	alcohol dehydrogenase
B446_RS33760	COG3321	synthase
B446_RS33775	COG0477	Major facilitator Superfamily
B446_RS33785	COG2124	cytochrome p450
B446_RS33830	COG0165	Argininosuccinate lyase
B446_RS33840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B446_RS33855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS33900	COG3251	PFAM MbtH domain protein
B446_RS33925	COG2268	Band 7 protein
B446_RS33945	COG2319	Wd-40 repeat
B446_RS33945	COG4249	Peptidase C14 caspase catalytic subunit p20
B446_RS34020	COG1309	transcriptional regulator
B446_RS34025	COG1063	alcohol dehydrogenase
B446_RS34040	COG0745	RESPONSE REGULATOR receiver
B446_RS34050	COG1136	(ABC) transporter
B446_RS34055	COG1136	(ABC) transporter
B446_RS34065	COG5002	protein histidine kinase activity
B446_RS34070	COG1902	pentaerythritol trinitrate reductase activity
B446_RS34100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B446_RS34115	COG0726	polysaccharide deacetylase
B446_RS34135	COG1819	glycosyl
B446_RS34145	COG0640	Transcriptional regulator
B446_RS34155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B446_RS34175	COG3209	COG3209 Rhs family protein
B446_RS34190	COG0596	Alpha beta hydrolase
B446_RS34210	COG0583	DNA-binding transcription factor activity
B446_RS34225	COG1028	Short-chain dehydrogenase reductase Sdr
B446_RS34260	COG1280	lysine exporter protein (LysE YggA)
B446_RS34280	COG2018	Roadblock/LC7 domain
B446_RS34300	COG1309	transcriptional regulator
B446_RS34310	COG3665	Urea carboxylase-associated protein
B446_RS34325	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS34360	COG1595	DNA-templated transcription, initiation
B446_RS34370	COG1595	DNA-templated transcription, initiation
B446_RS34420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS34435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B446_RS34440	COG1509	lysine 2,3-aminomutase activity
B446_RS34465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B446_RS34470	COG2814	Major facilitator Superfamily
B446_RS34475	COG1181	Belongs to the D-alanine--D-alanine ligase family
B446_RS34575	COG3209	COG3209 Rhs family protein
B446_RS34630	COG1278	Cold shock
B446_RS34655	COG2197	response regulator
B446_RS34680	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS34685	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B446_RS34725	COG0604	alcohol dehydrogenase
B446_RS34725	COG3321	synthase
B446_RS34740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B446_RS34765	COG0477	Major facilitator Superfamily
B446_RS34770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B446_RS34775	COG1819	glycosyl
B446_RS34830	COG2124	cytochrome p450
B446_RS34835	COG3103	Sh3 type 3 domain protein
B446_RS34835	COG1388	LysM domain
B446_RS34835	COG0791	NLP P60 protein
B446_RS34845	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS34850	COG1366	Belongs to the anti-sigma-factor antagonist family
B446_RS34855	COG2172	sigma factor antagonist activity
B446_RS34865	COG5002	protein histidine kinase activity
B446_RS34865	COG2198	Histidine kinase
B446_RS34865	COG0784	Response regulator, receiver
B446_RS34890	COG1595	DNA-templated transcription, initiation
B446_RS34940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B446_RS34945	COG0019	diaminopimelate decarboxylase activity
B446_RS34960	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B446_RS34975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B446_RS35025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B446_RS35070	COG1672	PFAM Archaeal ATPase
B446_RS35070	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B446_RS35170	COG0667	Aldo Keto reductase
B446_RS35210	COG0084	hydrolase, TatD family'
B446_RS36000	COG1309	transcriptional regulator
B446_RS36055	COG1397	ADP-ribosylglycohydrolase
B446_RS36075	COG4585	Histidine kinase
B446_RS36100	COG0515	serine threonine protein kinase
B446_RS36100	COG2815	serine threonine protein kinase
B446_RS36120	COG2226	methyltransferase
B446_RS36160	COG3629	intracellular signal transduction
B446_RS36160	COG3903	Transcriptional regulator
B446_RS36175	COG2205	protein histidine kinase activity