locus-tag class description EJ357_RS00085 ENOG4107RH8 nuclease SbcCD subunit D EJ357_RS00090 ENOG4105EYH Exonuclease EJ357_RS00215 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EJ357_RS00235 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS00245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJ357_RS00265 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS00405 ENOG4105C0W non-ribosomal peptide synthetase EJ357_RS00430 ENOG4105I1F Resistance protein EJ357_RS00475 ENOG4105CHR reductase EJ357_RS00525 ENOG4107QIZ NADH dehydrogenase EJ357_RS00625 ENOG4105EC3 peptidase S51, dipeptidase E EJ357_RS00645 ENOG4105VEQ Cold shock protein EJ357_RS00790 ENOG4108RYK Nad-dependent epimerase dehydratase EJ357_RS00830 ENOG4107W6X Transcriptional regulator EJ357_RS00850 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EJ357_RS00860 ENOG4108IJ9 (ABC) transporter EJ357_RS00865 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound EJ357_RS00890 ENOG41073TP transcriptional regulator EJ357_RS00905 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJ357_RS00920 ENOG4105ECY inositol monophosphatase EJ357_RS00925 ENOG4105G2Y Transcriptional regulator EJ357_RS00940 ENOG4107T5V SNARE associated Golgi EJ357_RS00945 ENOG4105BZU Histidine kinase EJ357_RS00950 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS00960 ENOG4107R13 MMPL domain protein EJ357_RS00975 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS00985 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS01005 ENOG4107RCI amp-dependent synthetase and ligase EJ357_RS01035 ENOG410880H cysteine synthase EJ357_RS01085 ENOG4105F95 Monooxygenase EJ357_RS01120 ENOG4105CY0 Metallo-Beta-Lactamase EJ357_RS01125 ENOG4105EBR Carboxylesterase EJ357_RS01135 ENOG4105C3K feS assembly ATPase SufC EJ357_RS01220 ENOG410905P Pyridoxamine 5-phosphate EJ357_RS01235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJ357_RS01260 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EJ357_RS01320 ENOG4108ZJ4 polysaccharide deacetylase EJ357_RS01330 ENOG4108762 serine threonine protein kinase EJ357_RS01350 ENOG4108Z6Z Transcriptional regulator EJ357_RS01395 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS01435 ENOG4105NAE bifunctional deaminase-reductase domain protein EJ357_RS01445 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ357_RS01470 ENOG4105CEP NADH dehydrogenase EJ357_RS01480 ENOG4105E98 transcriptional regulator DeoR family EJ357_RS01495 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS01505 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component EJ357_RS01510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS01525 ENOG4108478 ec 3.2.1.18 EJ357_RS01580 ENOG4105CPQ Dehydrogenase EJ357_RS01640 ENOG4106F60 Histidine kinase EJ357_RS01645 ENOG4105F44 Two component transcriptional regulator, winged helix family EJ357_RS01660 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS01665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS01720 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS01740 ENOG4105BZ1 (ABC) transporter EJ357_RS01750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ357_RS01765 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS01770 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EJ357_RS01775 ENOG4105E2A Dehydrogenase EJ357_RS01790 ENOG4105CHR reductase EJ357_RS01795 ENOG4107Z3H Transcriptional regulator, TetR family EJ357_RS01830 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EJ357_RS01835 ENOG4105C32 Amino acid ABC transporter (Permease) EJ357_RS01840 ENOG4108IV0 ABC, transporter EJ357_RS01845 ENOG4105C0Z ABC transporter EJ357_RS01930 ENOG4108TM9 integral membrane protein EJ357_RS02025 ENOG4108U3T pfkb domain protein EJ357_RS02035 ENOG4105CE4 GlcNAc 6-P deacetylase EJ357_RS02040 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase EJ357_RS02045 ENOG4106UW1 Major Facilitator superfamily EJ357_RS02055 ENOG4108PVU Nucleotidyl transferase EJ357_RS02060 ENOG41088YS Glycosyl transferase (Group 1 EJ357_RS02065 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJ357_RS02075 ENOG4108YUY EJ357_RS02090 ENOG41064E2 Xylose isomerase-like TIM barrel EJ357_RS02135 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EJ357_RS02140 ENOG4105C01 Dihydroxy-acid dehydratase EJ357_RS02145 ENOG4105CPQ Dehydrogenase EJ357_RS02180 ENOG4105CPC Aldo Keto reductase EJ357_RS02185 ENOG4106T9R serine protease EJ357_RS02200 ENOG4105NX3 Membrane EJ357_RS02220 ENOG4105BZ1 (ABC) transporter EJ357_RS02225 ENOG4105DFW ABC transporter EJ357_RS02235 ENOG4105DFW ABC transporter EJ357_RS02240 ENOG4105C2J ABC transporter EJ357_RS02245 ENOG4108HWW ABC transporter EJ357_RS02250 ENOG4105EBR Carboxylesterase EJ357_RS02265 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJ357_RS02320 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS02340 ENOG4108FN7 Aldo keto reductase EJ357_RS02400 ENOG4105D9P serine threonine protein kinase EJ357_RS02435 ENOG4105EW9 transcriptional regulator AsnC family EJ357_RS02440 ENOG4105DY8 decarboxylase EJ357_RS02530 ENOG4105D9G High-affinity EJ357_RS02570 ENOG4105DRS transport system, permease EJ357_RS02585 ENOG41066F8 ROK family EJ357_RS02645 ENOG4108M6P methyltransferase EJ357_RS02650 ENOG41073B4 coagulation factor 5 8 type domain-containing protein EJ357_RS02670 ENOG4105W49 UPF0434 protein EJ357_RS02685 ENOG4105DDC Oxidoreductase domain protein EJ357_RS02700 ENOG4105C87 Aminotransferase class I and II EJ357_RS02720 ENOG4105E2R ROK family EJ357_RS02730 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJ357_RS02735 ENOG4107FKK extracellular solute-binding protein family 1 EJ357_RS02775 ENOG4107TPS domain protein EJ357_RS02780 ENOG4108VCT Sulfite exporter TauE/SafE EJ357_RS02785 ENOG4105VPX protein, conserved in bacteria EJ357_RS02815 ENOG4105DQ5 transport system permease protein EJ357_RS02820 ENOG4105TVJ transport system, permease EJ357_RS02830 ENOG4108MES Periplasmic binding protein EJ357_RS02835 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJ357_RS02845 ENOG4105C6X Major Facilitator EJ357_RS02855 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJ357_RS02870 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ357_RS02875 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJ357_RS02890 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJ357_RS02900 ENOG4105EX0 alpha-galactosidase EJ357_RS02930 ENOG4107TXC Transcriptional regulator EJ357_RS02975 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family EJ357_RS03015 ENOG4107V9E glucose-1-phosphate thymidylyltransferase EJ357_RS03025 ENOG4105CJA serine threonine protein kinase EJ357_RS03075 ENOG4108JJA ABC, transporter EJ357_RS03080 ENOG4108JJA ABC, transporter EJ357_RS03100 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EJ357_RS03115 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS03120 ENOG4105CD5 CoA-binding domain protein EJ357_RS03140 ENOG4105DVW rieske (2Fe-2S) EJ357_RS03150 ENOG4105F38 ABC transporter, permease EJ357_RS03155 ENOG4105D38 putrescine abc transporter EJ357_RS03160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS03170 ENOG4105C26 Dehydrogenase EJ357_RS03175 ENOG4105K4I Scp-like extracellular EJ357_RS03205 ENOG4105DMF Dehydrogenase EJ357_RS03210 ENOG4108JQ1 Dehydrogenase EJ357_RS03235 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJ357_RS03255 ENOG4108Q50 Histidine kinase EJ357_RS03280 ENOG4105CPC Aldo Keto reductase EJ357_RS03310 ENOG4106YKD Cytochrome p-450 EJ357_RS03325 ENOG4105CHF Glutathione S-transferase EJ357_RS03350 ENOG4105CUB amino acid EJ357_RS03405 ENOG4105C26 Dehydrogenase EJ357_RS03410 ENOG4105RV9 Transcriptional regulator EJ357_RS03425 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EJ357_RS03465 ENOG4105DCG PHP domain protein EJ357_RS03495 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJ357_RS03525 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EJ357_RS03535 ENOG4108R86 Transcriptional regulator EJ357_RS03540 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJ357_RS03545 ENOG4105DDN Pentapeptide repeat-containing protein EJ357_RS03590 ENOG4108IJ6 ABC transporter EJ357_RS03615 ENOG4108SVB resolvase EJ357_RS03620 ENOG4108KPJ rna polymerase sigma factor EJ357_RS03635 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS03650 ENOG4105D4B ABC, transporter EJ357_RS03655 ENOG4105F5R ABC transporter EJ357_RS03660 ENOG4105CNN ABC, transporter EJ357_RS03665 ENOG4105C2J ABC transporter EJ357_RS03680 ENOG4105DET Rhamnulokinase EJ357_RS03685 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EJ357_RS03695 ENOG41080R8 Conserved Protein EJ357_RS03715 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS03725 ENOG4108IG5 Transcriptional regulator EJ357_RS03730 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB EJ357_RS03740 ENOG4105CHR reductase EJ357_RS03780 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS03795 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS03805 ENOG4108RAV Conserved protein EJ357_RS03810 ENOG4105CSH Transporter EJ357_RS03840 ENOG4107Y2X deaminase EJ357_RS03845 ENOG4105FDP GntR family transcriptional regulator EJ357_RS03865 ENOG4105E2D ec 3.2.1.52 EJ357_RS03870 ENOG4106R7G Glycoside hydrolase family 5 EJ357_RS03875 ENOG4108Q50 Histidine kinase EJ357_RS03935 ENOG410880H cysteine synthase EJ357_RS03965 ENOG4105EUB pirin domain protein EJ357_RS03990 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJ357_RS03995 ENOG4107QN2 dihydrolipoyl dehydrogenase EJ357_RS04000 ENOG41080RH Thioredoxin EJ357_RS04015 ENOG41060NJ transcriptional regulator EJ357_RS04030 ENOG4107RSM transcriptional regulator EJ357_RS04065 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) EJ357_RS04075 ENOG4105EMU Dehydrogenase EJ357_RS04105 ENOG41061H0 Monooxygenase EJ357_RS04115 ENOG4107W6X Transcriptional regulator EJ357_RS04135 ENOG4108YYC ycei family EJ357_RS04145 ENOG4105CSR polyphosphate kinase 2 EJ357_RS04155 ENOG4105EQX glucarate dehydratase EJ357_RS04160 ENOG4105C6Z Gluconate EJ357_RS04200 ENOG4108V1U phospholipid-binding protein EJ357_RS04215 ENOG4105CHR reductase EJ357_RS04245 ENOG4105CEP NADH dehydrogenase EJ357_RS04260 ENOG4107RDP Dehydrogenase EJ357_RS04265 ENOG4106T9R serine protease EJ357_RS04300 ENOG4105MVE transcriptional regulator EJ357_RS04310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ357_RS04315 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJ357_RS04340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ357_RS04350 ENOG4108KPJ rna polymerase sigma factor EJ357_RS04355 ENOG4108ZHJ Organic hydroperoxide resistance protein EJ357_RS04390 ENOG4105C1J atp-dependent rna helicase EJ357_RS04395 ENOG4105VEQ Cold shock protein EJ357_RS04405 ENOG4105E2A Dehydrogenase EJ357_RS04410 ENOG4105CUB amino acid EJ357_RS04430 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJ357_RS04440 ENOG4107QN2 dihydrolipoyl dehydrogenase EJ357_RS04450 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EJ357_RS04485 ENOG4105DZ6 Band 7 protein EJ357_RS04505 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process EJ357_RS04510 ENOG4108V75 Glutamine amidotransferase EJ357_RS04515 ENOG41067HS methyltransferase EJ357_RS04520 ENOG4105WKW Pfam:DUF1458 EJ357_RS04540 ENOG4107QN1 sodium solute EJ357_RS04550 ENOG41068HZ 50S ribosomal protein L32 EJ357_RS04555 ENOG4105CKI cobalamin synthesis protein EJ357_RS04560 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS04570 ENOG4105DEN Luciferase family EJ357_RS04595 ENOG4105E33 succinate dehydrogenase EJ357_RS04610 ENOG4105C5Q Transcriptional regulator EJ357_RS04615 ENOG4105E1F short-chain dehydrogenase reductase EJ357_RS04625 ENOG4108W5M transcriptional regulator EJ357_RS04630 ENOG4105BZU Histidine kinase EJ357_RS04670 ENOG4108ZJ4 polysaccharide deacetylase EJ357_RS04675 ENOG4105CRK lysyL-tRNA synthetase EJ357_RS04755 ENOG4105CHR reductase EJ357_RS04760 ENOG4105DIA mandelate racemase muconate lactonizing EJ357_RS04770 ENOG4105C2J ABC transporter EJ357_RS04795 ENOG4105CJN penicillin-binding protein EJ357_RS04835 ENOG4105BZ7 extracellular solute-binding protein family 1 EJ357_RS04840 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS04845 ENOG41066YJ Beta-lactamase EJ357_RS04860 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ357_RS04865 ENOG4106NMR serine protease EJ357_RS04895 ENOG4108R85 Short chain dehydrogenase EJ357_RS04930 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EJ357_RS04935 ENOG4107QPH glycogen) synthase EJ357_RS04955 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EJ357_RS04975 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EJ357_RS04980 ENOG4105BZ1 (ABC) transporter EJ357_RS04995 ENOG4105EPC oxidoreductase EJ357_RS05000 ENOG4108UGD Serine Threonine protein kinase EJ357_RS05025 ENOG4105E39 Enoyl-CoA hydratase EJ357_RS05030 ENOG4105D64 Mechanosensitive ion channel EJ357_RS05040 ENOG4105E9K Isocitrate dehydrogenase EJ357_RS05085 ENOG4106S2D Transcriptional regulator EJ357_RS05095 ENOG4106UW1 Major Facilitator superfamily EJ357_RS05130 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS05135 ENOG4105BZU Histidine kinase EJ357_RS05160 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EJ357_RS05165 ENOG4107PP3 Acetylornithine deacetylase EJ357_RS05175 ENOG4105I1F Resistance protein EJ357_RS05185 ENOG4105ECP epimerase EJ357_RS05190 ENOG4105EX0 alpha-galactosidase EJ357_RS05200 ENOG41060NJ transcriptional regulator EJ357_RS05210 ENOG4107TPY serine threonine protein kinase EJ357_RS05225 ENOG4105C10 Electron transfer flavoprotein EJ357_RS05250 ENOG4105PSQ Acyl-transferase EJ357_RS05265 ENOG4105C5W Aldolase EJ357_RS05280 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ357_RS05330 ENOG410841Q phosphoesterase PA-phosphatase related protein EJ357_RS05365 ENOG4105EQH reductase EJ357_RS05375 ENOG4105YVS arsR family transcriptional regulator EJ357_RS05380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ357_RS05385 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJ357_RS05390 ENOG4107S46 esterase, PHB depolymerase EJ357_RS05410 ENOG4105CSU acyl-Coa dehydrogenase EJ357_RS05425 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EJ357_RS05430 ENOG4105RD7 BadF BadG BcrA BcrD EJ357_RS05475 ENOG4107VXZ Hydrolase EJ357_RS05510 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit EJ357_RS05515 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit EJ357_RS05520 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit EJ357_RS05525 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit EJ357_RS05600 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) EJ357_RS05635 ENOG4105K4H Nlp p60 protein EJ357_RS05645 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS05655 ENOG4107QNK )-transporter EJ357_RS05660 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EJ357_RS05665 ENOG4105F0H myo-inositol catabolism protein EJ357_RS05700 ENOG4105DNP FAD linked oxidase domain protein EJ357_RS05715 ENOG4105EHG Permease protein EJ357_RS05720 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS05740 ENOG4105CAQ asparagine synthetase EJ357_RS05755 ENOG4105E0A ABC, transporter EJ357_RS05760 ENOG4105EHG Permease protein EJ357_RS05860 ENOG4108JGH Tetr family transcriptional regulator EJ357_RS05865 ENOG4105C57 major facilitator superfamily EJ357_RS05875 ENOG4107RCI amp-dependent synthetase and ligase EJ357_RS05885 ENOG4108JA1 polyketide synthase EJ357_RS05925 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ357_RS05930 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS06010 ENOG4105ERH Fumarylacetoacetate hydrolase EJ357_RS06025 ENOG41061H0 Monooxygenase EJ357_RS06035 ENOG4105ERH Fumarylacetoacetate hydrolase EJ357_RS06055 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) EJ357_RS06070 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS06080 ENOG4107FKK extracellular solute-binding protein family 1 EJ357_RS06090 ENOG4105DRS transport system, permease EJ357_RS06140 ENOG4105DRS transport system, permease EJ357_RS06165 ENOG4105CHR reductase EJ357_RS06190 ENOG4107ZED Uncharacterised protein family UPF0047 EJ357_RS06195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJ357_RS06200 ENOG4105E2Y ABC, transporter EJ357_RS06210 ENOG4105H3G oxidoreductase EJ357_RS06220 ENOG4105BZ1 (ABC) transporter EJ357_RS06230 ENOG4105CK2 sodium dicarboxylate symporter EJ357_RS06245 ENOG4105BZ1 (ABC) transporter EJ357_RS06250 ENOG4105BZ1 (ABC) transporter EJ357_RS06260 ENOG4105NRA 50s ribosomal protein l31 type b EJ357_RS06275 ENOG4105C29 acyl-CoA thioesterase EJ357_RS06285 ENOG4105GWZ Roadblock lc7 family protein EJ357_RS06310 ENOG4105DHQ Histidine kinase EJ357_RS06315 ENOG4105BZU Histidine kinase EJ357_RS06320 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EJ357_RS06325 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EJ357_RS06360 ENOG4105C0D helicase EJ357_RS06390 ENOG4105E2R ROK family EJ357_RS06395 ENOG4107SCA Formamidase (EC 3.5.1.49) EJ357_RS06405 ENOG4107RR1 TRANSCRIPTIONal EJ357_RS06415 ENOG4105C26 Dehydrogenase EJ357_RS06435 ENOG4107RN3 metallophosphoesterase EJ357_RS06445 ENOG4105CHP RNA polymerase EJ357_RS06450 ENOG4105GRZ Ycii-related protein EJ357_RS06460 ENOG4106W5V Membrane EJ357_RS06475 ENOG4106A3M Cytochrome p-450 EJ357_RS06490 ENOG4108HQ0 Exopolysaccharide biosynthesis protein EJ357_RS06505 ENOG4105D2B acyl-CoA dehydrogenase EJ357_RS06510 ENOG4105D2B acyl-CoA dehydrogenase EJ357_RS06515 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJ357_RS06520 ENOG4105CFF transcriptional regulator EJ357_RS06525 ENOG4105C3M thioredoxin reductase EJ357_RS06530 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) EJ357_RS06540 ENOG4105C26 Dehydrogenase EJ357_RS06555 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS06565 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJ357_RS06575 ENOG4105F1K Glutamine amidotransferase EJ357_RS06580 ENOG4105CTQ phosphohexokinase EJ357_RS06605 ENOG4108HRK Histidine kinase EJ357_RS06620 ENOG4108NEV two component transcriptional regulator, LytTR family EJ357_RS06630 ENOG4105CIK Amidinotransferase EJ357_RS06635 ENOG4105C8Y Acetylornithine aminotransferase EJ357_RS06660 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) EJ357_RS06670 ENOG4105CQM Urea amidohydrolase subunit alpha EJ357_RS06675 ENOG4105KI2 Urea amidohydrolase subunit beta EJ357_RS06680 ENOG4108YZ9 Urea amidohydrolase subunit gamma EJ357_RS06685 ENOG4108Q5F Tetr family transcriptional regulator EJ357_RS06710 ENOG4105K4H Nlp p60 protein EJ357_RS06715 ENOG4105N14 lysine exporter protein LysE YggA EJ357_RS06720 ENOG4105DDW LysR family Transcriptional regulator EJ357_RS06745 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EJ357_RS06750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ357_RS06755 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EJ357_RS06780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS06795 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS06805 ENOG4105FBW Monooxygenase EJ357_RS06810 ENOG4108R6G acetyltransferase EJ357_RS06835 ENOG4105C83 adenylosuccinate lyase EJ357_RS06840 ENOG4108VCA G U mismatch-specific DNA glycosylase EJ357_RS06855 ENOG4105BZU Histidine kinase EJ357_RS06860 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS06865 ENOG4105DKQ ROK family EJ357_RS06870 ENOG4105FDP GntR family transcriptional regulator EJ357_RS06875 ENOG4108KPJ rna polymerase sigma factor EJ357_RS06880 ENOG4106HB6 Alpha beta hydrolase EJ357_RS06890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS06930 ENOG4108PSK reductase EJ357_RS06960 ENOG4105EYH Exonuclease EJ357_RS06965 ENOG4107RH8 nuclease SbcCD subunit D EJ357_RS07015 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EJ357_RS07025 ENOG4105C8N cysteinyl-tRNA synthetase EJ357_RS07030 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJ357_RS07035 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJ357_RS07040 ENOG4105EJQ L-serine dehydratase EJ357_RS07045 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJ357_RS07050 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EJ357_RS07060 ENOG4105DVW rieske (2Fe-2S) EJ357_RS07085 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJ357_RS07100 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component EJ357_RS07105 ENOG4108IJ7 Glycine betaine EJ357_RS07130 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EJ357_RS07140 ENOG4105DVW rieske (2Fe-2S) EJ357_RS07145 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase EJ357_RS07150 ENOG4105VQD rieske 2fe-2S domain-containing protein EJ357_RS07170 ENOG4105K4P CoA-binding domain protein EJ357_RS07205 ENOG4108Z0R Transferase EJ357_RS07215 ENOG4105EBR Carboxylesterase EJ357_RS07225 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ357_RS07260 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS07280 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ357_RS07310 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EJ357_RS07315 ENOG4105EP9 oxidoreductase EJ357_RS07345 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EJ357_RS07350 ENOG4105DEF Extracellular solute-binding protein, family 5 EJ357_RS07355 ENOG4105CHR reductase EJ357_RS07395 ENOG4108Q5Y Membrane EJ357_RS07400 ENOG4105CSW GntR family transcriptional regulator EJ357_RS07450 ENOG4107TIF Phenazine biosynthesis protein, PhzF family EJ357_RS07530 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EJ357_RS07535 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJ357_RS07540 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJ357_RS07580 ENOG4105F4R Transcriptional regulator mode EJ357_RS07585 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EJ357_RS07595 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EJ357_RS07665 ENOG4105C5Y PTS System EJ357_RS07670 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EJ357_RS07680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ357_RS07705 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ357_RS07710 ENOG4105BZU Histidine kinase EJ357_RS07715 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJ357_RS07720 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EJ357_RS07790 ENOG4105CFM UPF0317 protein EJ357_RS07795 ENOG4105E7W lamb ycsf family protein EJ357_RS07800 ENOG4105P4J Allophanate hydrolase, subunit 1 EJ357_RS07810 ENOG41090WU lipolytic protein G-D-S-L family EJ357_RS07815 ENOG4108MJN Glycosyl Transferase EJ357_RS07835 ENOG4105JXB ankyrin repeat-containing protein EJ357_RS07865 ENOG4105DEU major facilitator superfamily EJ357_RS07870 ENOG4105Q70 EJ357_RS07880 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) EJ357_RS07890 ENOG4105EW9 transcriptional regulator AsnC family EJ357_RS07915 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS07975 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EJ357_RS07980 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase EJ357_RS07985 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EJ357_RS07990 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EJ357_RS08010 ENOG4105E2R ROK family EJ357_RS08020 ENOG4105C2W permease EJ357_RS08025 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJ357_RS08055 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 EJ357_RS08060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS08070 ENOG4105F38 ABC transporter, permease EJ357_RS08080 ENOG4108TZY GntR Family Transcriptional Regulator EJ357_RS08095 ENOG4105CUB amino acid EJ357_RS08125 ENOG4105DKT Transcriptional regulator EJ357_RS08130 ENOG4105DJV ribulose-phosphate 3-epimerase EJ357_RS08135 ENOG4105EYF MMPL domain protein EJ357_RS08145 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EJ357_RS08160 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EJ357_RS08170 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EJ357_RS08175 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EJ357_RS08185 ENOG4105SKN orotidine 5''-phosphate decarboxylase EJ357_RS08190 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EJ357_RS08195 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJ357_RS08200 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EJ357_RS08210 ENOG4105CD3 dihydroorotase EJ357_RS08215 ENOG4105CXT aspartate transcarbamylase EJ357_RS08220 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EJ357_RS08230 ENOG410803B Involved in the transcription termination process (By similarity) EJ357_RS08235 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EJ357_RS08240 ENOG4105DC7 peptidase M24 EJ357_RS08250 ENOG4105D49 3-dehydroquinate synthase EJ357_RS08255 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EJ357_RS08260 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EJ357_RS08270 ENOG4105HHA aminodeoxychorismate lyase EJ357_RS08280 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EJ357_RS08285 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ357_RS08300 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EJ357_RS08315 ENOG4105CUT histidyl-tRNA synthetase EJ357_RS08325 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) EJ357_RS08330 ENOG4105C99 atpase involved in dna repair EJ357_RS08335 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJ357_RS08345 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EJ357_RS08350 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJ357_RS08355 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJ357_RS08365 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EJ357_RS08370 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EJ357_RS08375 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EJ357_RS08380 ENOG4105CDY transcriptional regulatory protein EJ357_RS08385 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EJ357_RS08390 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EJ357_RS08400 ENOG4105E2K Glycosyl transferase (Group 1 EJ357_RS08405 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase EJ357_RS08435 ENOG4105C22 threonyL-tRNA synthetase EJ357_RS08450 ENOG4108JDX DNA polymerase iii, epsilon subunit EJ357_RS08470 ENOG4105EKC EJ357_RS08480 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJ357_RS08485 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJ357_RS08490 ENOG410769Z extracellular solute-binding protein family 1 EJ357_RS08505 ENOG4105KF0 sporulation and cell division protein, SsgA EJ357_RS08525 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ357_RS08530 ENOG4105F0I Aminotransferase EJ357_RS08535 ENOG4105CRQ synthase (Component I) EJ357_RS08590 ENOG4105M6F mutator MutT protein EJ357_RS08600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJ357_RS08605 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EJ357_RS08620 ENOG4105D01 (LipO)protein EJ357_RS08625 ENOG4105D01 (LipO)protein EJ357_RS08630 ENOG4108UMI ABC transporter, permease EJ357_RS08635 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS08670 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS08680 ENOG4105C57 major facilitator superfamily EJ357_RS08685 ENOG4105RJZ Transcriptional regulator EJ357_RS08700 ENOG4105CH7 arginosuccinase EJ357_RS08725 ENOG4107EFR Flavocytochrome c EJ357_RS08735 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EJ357_RS08740 ENOG4105C8Y Acetylornithine aminotransferase EJ357_RS08745 ENOG4105CAS nag kinase EJ357_RS08750 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EJ357_RS08755 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EJ357_RS08815 ENOG4105F32 YngK protein EJ357_RS08845 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EJ357_RS08850 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EJ357_RS08855 ENOG4105BZU Histidine kinase EJ357_RS08860 ENOG4108RWN rrna methyltransferase EJ357_RS08865 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EJ357_RS08870 ENOG41084BS 50S ribosomal protein L35 EJ357_RS08875 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EJ357_RS08925 ENOG4105C26 Dehydrogenase EJ357_RS08930 ENOG4105C5F glutamine synthetase EJ357_RS08940 ENOG4105CUB amino acid EJ357_RS08945 ENOG4108Z86 Glutamine amidotransferase EJ357_RS08975 ENOG4108HQS Glycine betaine EJ357_RS08980 ENOG4108IJ7 Glycine betaine EJ357_RS08985 ENOG4105HFS 5'-3' exonuclease EJ357_RS09020 ENOG4105D3G Pseudouridine synthase EJ357_RS09085 ENOG4105EEM helicase EJ357_RS09095 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EJ357_RS09100 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EJ357_RS09130 ENOG4108V1T peptidylprolyl cis-trans isomerase EJ357_RS09135 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) EJ357_RS09145 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS09150 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) EJ357_RS09155 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) EJ357_RS09165 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) EJ357_RS09170 ENOG4105E5F proteasome EJ357_RS09175 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) EJ357_RS09215 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS09220 ENOG4105DEF Extracellular solute-binding protein, family 5 EJ357_RS09225 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ357_RS09230 ENOG4107URF beta-phospho-glucomutase EJ357_RS09235 ENOG4105C3R Methionine synthase EJ357_RS09240 ENOG4108K8U Glycerol operon regulatory protein EJ357_RS09245 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJ357_RS09250 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EJ357_RS09265 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EJ357_RS09270 ENOG4108HWV )-transporter EJ357_RS09275 ENOG4105C2J ABC transporter EJ357_RS09285 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EJ357_RS09290 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) EJ357_RS09295 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EJ357_RS09305 ENOG4105WAB arsR family transcriptional regulator EJ357_RS09310 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EJ357_RS09320 ENOG4108JQ9 ABC transporter EJ357_RS09325 ENOG4105UIB (ABC) transporter EJ357_RS09335 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EJ357_RS09340 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS09345 ENOG4105JXH GntR family transcriptional regulator EJ357_RS09370 ENOG4105C8N cysteinyl-tRNA synthetase EJ357_RS09385 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ357_RS09390 ENOG4105D7N magnesium and cobalt transport protein CorA EJ357_RS09400 ENOG4105DYW oxidoreductase EJ357_RS09405 ENOG4105CPC Aldo Keto reductase EJ357_RS09425 ENOG4105S2J secreted protein EJ357_RS09435 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJ357_RS09450 ENOG4105CD8 aminopeptidase N EJ357_RS09460 ENOG4108HMN Caspase domain EJ357_RS09470 ENOG4105K5B UPF0225 protein EJ357_RS09475 ENOG4105C6F GntR Family Transcriptional Regulator EJ357_RS09480 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EJ357_RS09485 ENOG4105C6Z Gluconate EJ357_RS09490 ENOG4105CHR reductase EJ357_RS09495 ENOG4105CPQ Dehydrogenase EJ357_RS09530 ENOG4105PTV Nudix Hydrolase EJ357_RS09540 ENOG4105VG5 Membrane EJ357_RS09550 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJ357_RS09570 ENOG4108IG5 Transcriptional regulator EJ357_RS09575 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS09580 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJ357_RS09585 ENOG4105EHZ conserved protein UCP016719 EJ357_RS09620 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EJ357_RS09625 ENOG4108Z4X TRANSCRIPTIONal EJ357_RS09645 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS09655 ENOG4108ZHR arsR family transcriptional regulator EJ357_RS09665 ENOG4105CSH Transporter EJ357_RS09705 ENOG4105D4T Citrate transporter EJ357_RS09710 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJ357_RS09715 ENOG4108SGK Tetr family transcriptional regulator EJ357_RS09725 ENOG4105F1J Homogentisate 1,2-dioxygenase EJ357_RS09760 ENOG4105RNG membrane EJ357_RS09765 ENOG4105K6V RNA polymerase EJ357_RS09780 ENOG41061MD high-affinity nickel-transporter EJ357_RS09790 ENOG4108TCJ secreted hydrolase EJ357_RS09795 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS09820 ENOG4107BJW polysaccharide deacetylase EJ357_RS09845 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS09905 ENOG4105C0B DNA polymerase III (alpha subunit) EJ357_RS09925 ENOG4106NMR serine protease EJ357_RS09940 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EJ357_RS09945 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS09950 ENOG4105C57 major facilitator superfamily EJ357_RS09960 ENOG410841Q phosphoesterase PA-phosphatase related protein EJ357_RS10000 ENOG4105C0Z ABC transporter EJ357_RS10005 ENOG4108IV0 ABC, transporter EJ357_RS10010 ENOG4106839 domain protein EJ357_RS10030 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EJ357_RS10040 ENOG4105CAT Cytidine monophosphate kinase EJ357_RS10095 ENOG4105FE9 pseudouridine synthase EJ357_RS10100 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EJ357_RS10105 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EJ357_RS10120 ENOG4105DCF alanine dehydrogenase EJ357_RS10135 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EJ357_RS10140 ENOG4105BZP glycoside hydrolase 15-related EJ357_RS10165 ENOG4108MJN Glycosyl Transferase EJ357_RS10175 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EJ357_RS10180 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EJ357_RS10200 ENOG4105E0A ABC, transporter EJ357_RS10205 ENOG4105TVJ transport system, permease EJ357_RS10210 ENOG4105DQ5 transport system permease protein EJ357_RS10215 ENOG4105DSU hydrolase EJ357_RS10250 ENOG4108VX5 3-methyladenine DNA glycosylase EJ357_RS10260 ENOG4108V1U phospholipid-binding protein EJ357_RS10280 ENOG4105DKW ABC transporter EJ357_RS10295 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS10300 ENOG4105ENE Histidine kinase EJ357_RS10305 ENOG4105EMU Dehydrogenase EJ357_RS10310 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EJ357_RS10320 ENOG4105IDI abc transporter atp-binding protein EJ357_RS10330 ENOG4105EAC phosphoserine phosphatase EJ357_RS10355 ENOG4107YCY Transcriptional regulator EJ357_RS10375 ENOG4105D1U peptidase U62 modulator of DNA gyrase EJ357_RS10385 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJ357_RS10405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ357_RS10410 ENOG4107QN1 sodium solute EJ357_RS10425 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F EJ357_RS10445 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJ357_RS10470 ENOG4105D22 carbon starvation protein EJ357_RS10495 ENOG4105BZP glycoside hydrolase 15-related EJ357_RS10500 ENOG4105CHR reductase EJ357_RS10525 ENOG4105VBF alkaline shock protein EJ357_RS10535 ENOG41060WC Enoyl-CoA hydratase EJ357_RS10545 ENOG4105C5H ABC transporter EJ357_RS10570 ENOG4107W7X Aldolase EJ357_RS10590 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) EJ357_RS10595 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EJ357_RS10600 ENOG4105CTK cobaltochelatase, cobn subunit EJ357_RS10610 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EJ357_RS10615 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EJ357_RS10625 ENOG4105CIA precorrin-4 C(11)-methyltransferase EJ357_RS10635 ENOG4105E4R Precorrin-3B C17-methyltransferase EJ357_RS10640 ENOG41081F0 Precorrin-8x methylmutase EJ357_RS10670 ENOG4105EAD ABC transporter EJ357_RS10675 ENOG4106PMH Extracellular solute-binding protein family 3 EJ357_RS10680 ENOG4105C5R Aminotransferase EJ357_RS10690 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase EJ357_RS10695 ENOG4108JPW Aminotransferase EJ357_RS10700 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) EJ357_RS10705 ENOG4105EV8 ectoine hydroxylase EJ357_RS10725 ENOG4105K6V RNA polymerase EJ357_RS10730 ENOG4105C9B Cysteine desulfurase EJ357_RS10745 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS10765 ENOG4107HP6 Transcriptional regulator EJ357_RS10780 ENOG4105BZU Histidine kinase EJ357_RS10785 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS10790 ENOG4105CJN penicillin-binding protein EJ357_RS10795 ENOG4105C7N Xanthine uracil vitamin C permease EJ357_RS10800 ENOG4105NAF rna polymerase sigma factor EJ357_RS10815 ENOG4108J21 pectate lyase EJ357_RS10835 ENOG4105NBR Pectinesterase EJ357_RS10845 ENOG4107TDE lipolytic protein G-D-S-L family EJ357_RS10890 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJ357_RS10900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ357_RS10905 ENOG4105DRR Transcriptional regulator, GntR family EJ357_RS10910 ENOG4108RQ5 Beta-lactamase domain-containing protein EJ357_RS10940 ENOG4105E9Z Nad-dependent epimerase dehydratase EJ357_RS10965 ENOG4105CPQ Dehydrogenase EJ357_RS10980 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS10990 ENOG4107XBN GntR Family Transcriptional Regulator EJ357_RS11040 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ357_RS11050 ENOG4105NAF rna polymerase sigma factor EJ357_RS11060 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) EJ357_RS11065 ENOG4108RFG Tetr family transcriptional regulator EJ357_RS11085 ENOG4105VG1 fes assembly suf system protein EJ357_RS11090 ENOG4108UNV SUF system FeS assembly protein, NifU family EJ357_RS11095 ENOG4105C9B Cysteine desulfurase EJ357_RS11100 ENOG4105C3K feS assembly ATPase SufC EJ357_RS11110 ENOG4105JRK feS assembly protein SufD EJ357_RS11145 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) EJ357_RS11165 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EJ357_RS11180 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJ357_RS11195 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) EJ357_RS11200 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EJ357_RS11205 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component EJ357_RS11215 ENOG4105CG3 alpha amylase, catalytic region EJ357_RS11220 ENOG4105WEM extracellular solute-binding protein EJ357_RS11225 ENOG4105U3E Transcriptional regulator EJ357_RS11230 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJ357_RS11245 ENOG4107QP8 phosphohexose isomerase EJ357_RS11265 ENOG4105CP7 Triose-phosphate isomerase EJ357_RS11270 ENOG4105BZA Phosphoglycerate kinase EJ357_RS11275 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJ357_RS11285 ENOG4105CIE May be required for sporulation (By similarity) EJ357_RS11290 ENOG4105CHW UPF0052 protein EJ357_RS11295 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EJ357_RS11300 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJ357_RS11310 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS11320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ357_RS11335 ENOG4107R0W ABC transporter EJ357_RS11340 ENOG4105E5Q amino acid AbC transporter EJ357_RS11350 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EJ357_RS11355 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJ357_RS11360 ENOG4105CSH Transporter EJ357_RS11385 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EJ357_RS11390 ENOG4105BZU Histidine kinase EJ357_RS11395 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ357_RS11400 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ357_RS11415 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EJ357_RS11420 ENOG4108RVA ribokinase EJ357_RS11425 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS11430 ENOG4105D7N magnesium and cobalt transport protein CorA EJ357_RS11465 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJ357_RS11470 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS11540 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS11550 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EJ357_RS11600 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EJ357_RS11605 ENOG4105DRR Transcriptional regulator, GntR family EJ357_RS11610 ENOG4105C57 major facilitator superfamily EJ357_RS11665 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EJ357_RS11685 ENOG4105CQ7 ATP-dependent helicase EJ357_RS11725 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) EJ357_RS11745 ENOG4105C32 Amino acid ABC transporter (Permease) EJ357_RS11750 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EJ357_RS11755 ENOG4105C0Z ABC transporter EJ357_RS11760 ENOG4108IV0 ABC, transporter EJ357_RS11790 ENOG4105CGH 5'-nucleotidase EJ357_RS11810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS11815 ENOG4105EHE chorismate mutase- prephenate dehydrogenase EJ357_RS11820 ENOG41063TF transcriptional regulator (AraC EJ357_RS11840 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJ357_RS11855 ENOG4105E39 Enoyl-CoA hydratase EJ357_RS11870 ENOG4105EA8 2-Nitropropane dioxygenase EJ357_RS11875 ENOG4105F2C Acetyl-CoA acetyltransferase EJ357_RS11880 ENOG4108RZE Tetr family transcriptional regulator EJ357_RS11885 ENOG4105CHR reductase EJ357_RS11890 ENOG4105CC9 acyl-Coa dehydrogenase EJ357_RS11900 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJ357_RS11905 ENOG4105MUA Resistance protein EJ357_RS11925 ENOG4105CBC glutamate synthase EJ357_RS11935 ENOG41065RQ ADP-ribosylation crystallin J1 EJ357_RS11955 ENOG4108RVA ribokinase EJ357_RS11960 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EJ357_RS11970 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EJ357_RS11980 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EJ357_RS11985 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EJ357_RS11995 ENOG4105DK0 Indole-3-glycerol phosphate synthase EJ357_RS12020 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EJ357_RS12040 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EJ357_RS12045 ENOG4108176 endoribonuclease L-psp EJ357_RS12050 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EJ357_RS12055 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EJ357_RS12060 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EJ357_RS12065 ENOG4105CIH Imidazole acetol-phosphate transaminase EJ357_RS12070 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EJ357_RS12090 ENOG4108Z66 YbaK ebsC protein EJ357_RS12120 ENOG4105C0B DNA polymerase III (alpha subunit) EJ357_RS12155 ENOG4105CHR reductase EJ357_RS12175 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EJ357_RS12190 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EJ357_RS12195 ENOG4107VQS DivIVA family EJ357_RS12205 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EJ357_RS12210 ENOG4105DFA alanine racemase domain protein EJ357_RS12215 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EJ357_RS12220 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EJ357_RS12225 ENOG4105ME9 cell division protein FtsQ EJ357_RS12230 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJ357_RS12240 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EJ357_RS12245 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EJ357_RS12255 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EJ357_RS12260 ENOG4105CJN penicillin-binding protein EJ357_RS12270 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EJ357_RS12280 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ357_RS12320 ENOG4107Z3H Transcriptional regulator, TetR family EJ357_RS12330 ENOG4107VFM Dehydrogenase EJ357_RS12345 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EJ357_RS12375 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EJ357_RS12385 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EJ357_RS12400 ENOG4108UQY Iron-storage protein EJ357_RS12410 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase EJ357_RS12425 ENOG4105C5I Dehydrogenase EJ357_RS12430 ENOG4105CTQ phosphohexokinase EJ357_RS12440 ENOG4105ENE Histidine kinase EJ357_RS12460 ENOG4105EMN RNA polymerase sigma factor EJ357_RS12475 ENOG4105DKQ ROK family EJ357_RS12485 ENOG4105D0U Arsenite-activated ATPase (ArsA) EJ357_RS12520 ENOG4105UQX Mate efflux family protein EJ357_RS12600 ENOG4108I0Q anthranilate phosphoribosyltransferase EJ357_RS12605 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJ357_RS12610 ENOG4107EUI c reductase, iron-sulfur EJ357_RS12615 ENOG4107UDY cytochrome C EJ357_RS12620 ENOG4105CCU oxidase (Subunit III) EJ357_RS12630 ENOG4107UBC ErfK ybiS ycfS ynhG family protein EJ357_RS12635 ENOG4105MCD Part of cytochrome c oxidase, its function is EJ357_RS12640 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJ357_RS12645 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EJ357_RS12655 ENOG4107T4Z adenosine kinase EJ357_RS12680 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EJ357_RS12685 ENOG4108762 serine threonine protein kinase EJ357_RS12735 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS12740 ENOG4105BZU Histidine kinase EJ357_RS12760 ENOG4105DXX methyltransferase EJ357_RS12770 ENOG4108YZT Adenosylcobinamide kinase EJ357_RS12780 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EJ357_RS12795 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EJ357_RS12820 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EJ357_RS12840 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EJ357_RS12880 ENOG4105ECP epimerase EJ357_RS12895 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EJ357_RS12900 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EJ357_RS12920 ENOG4105C5F glutamine synthetase EJ357_RS12935 ENOG4105D0M Protease HtpX homolog EJ357_RS12965 ENOG4108222 arsenate reductase EJ357_RS12970 ENOG4106SPC secreted protein EJ357_RS12975 ENOG4107R5B glutamine synthetase EJ357_RS12985 ENOG4107NHD transcriptional regulator EJ357_RS13000 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS13065 ENOG4105CG3 alpha amylase, catalytic region EJ357_RS13070 ENOG4105EG2 ABC transporter, permease EJ357_RS13080 ENOG4105BZ7 extracellular solute-binding protein family 1 EJ357_RS13085 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS13095 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EJ357_RS13110 ENOG4105C5F glutamine synthetase EJ357_RS13120 ENOG41081JD Transcriptional regulator EJ357_RS13135 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EJ357_RS13140 ENOG4105C57 major facilitator superfamily EJ357_RS13155 ENOG4105F27 Major Facilitator EJ357_RS13180 ENOG4107XZ0 Peptidase M50 EJ357_RS13195 ENOG4105W5A BNR Asp-box repeat protein EJ357_RS13235 ENOG4105EHG Permease protein EJ357_RS13245 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS13250 ENOG410650H (LipO)protein EJ357_RS13255 ENOG4105DBE peroxidase EJ357_RS13265 ENOG4106A0S EJ357_RS13275 ENOG4105YIP Tetr family transcriptional regulator EJ357_RS13295 ENOG4107S1E Beta-lactamase EJ357_RS13300 ENOG4105C2C drug resistance transporter, Bcr CflA EJ357_RS13310 ENOG4105DGI Alkaline phosphatase EJ357_RS13315 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJ357_RS13320 ENOG4105CPC Aldo Keto reductase EJ357_RS13330 ENOG4108VGI doxx family EJ357_RS13350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS13380 ENOG4105CY3 ABC transporter, permease EJ357_RS13500 ENOG4105E7U AraC family transcriptional regulator EJ357_RS13525 ENOG4107XFJ UPF0246 protein EJ357_RS13530 ENOG4108UHU Aldolase EJ357_RS13545 ENOG4105EGD dinuclear metal center protein, YbgI family EJ357_RS13555 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr EJ357_RS13600 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EJ357_RS13610 ENOG4105DYW oxidoreductase EJ357_RS13625 ENOG4107QVI Methyltransferase, type 11 EJ357_RS13630 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJ357_RS13635 ENOG4108SGK Tetr family transcriptional regulator EJ357_RS13685 ENOG4105BZ1 (ABC) transporter EJ357_RS13700 ENOG4106A3M Cytochrome p-450 EJ357_RS13705 ENOG4105F2C Acetyl-CoA acetyltransferase EJ357_RS13770 ENOG4105NAE bifunctional deaminase-reductase domain protein EJ357_RS13830 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJ357_RS13870 ENOG4105DAX Pfam:DUF2983 EJ357_RS13915 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EJ357_RS13920 ENOG4105EYW Ion transport protein EJ357_RS13950 ENOG4105CPC Aldo Keto reductase EJ357_RS13955 ENOG4105VUF Transcriptional regulator EJ357_RS13970 ENOG4105EYF MMPL domain protein EJ357_RS13990 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ357_RS13995 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EJ357_RS14015 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EJ357_RS14020 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJ357_RS14035 ENOG4106KR7 LysR family Transcriptional regulator EJ357_RS14040 ENOG4105NGS secreted protein EJ357_RS14070 ENOG4108ZHJ Organic hydroperoxide resistance protein EJ357_RS14075 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EJ357_RS14085 ENOG41061ZR Transcriptional regulator EJ357_RS14145 ENOG41062B0 ABC transporter, permease EJ357_RS14150 ENOG4107R9N ABC transporter EJ357_RS14155 ENOG4105C2J ABC transporter EJ357_RS14160 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EJ357_RS14165 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS14170 ENOG4105CXK mandelate racemase muconate lactonizing EJ357_RS14185 ENOG4105DFW ABC transporter EJ357_RS14190 ENOG4105C2J ABC transporter EJ357_RS14195 ENOG4108HWW ABC transporter EJ357_RS14200 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EJ357_RS14205 ENOG4105CIH Imidazole acetol-phosphate transaminase EJ357_RS14210 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) EJ357_RS14265 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ357_RS14310 ENOG410635A Membrane EJ357_RS14340 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EJ357_RS14345 ENOG41069M3 Transcriptional regulator EJ357_RS14390 ENOG41073B4 coagulation factor 5 8 type domain-containing protein EJ357_RS14455 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EJ357_RS14460 ENOG4105EXC Acyl-transferase EJ357_RS14465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS14470 ENOG4105C6F GntR Family Transcriptional Regulator EJ357_RS14480 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS14485 ENOG4105D8K carboxyl transferase EJ357_RS14490 ENOG4105DFF Rod shape-determining protein mreb EJ357_RS14500 ENOG4106F60 Histidine kinase EJ357_RS14505 ENOG4105ETX regulatoR EJ357_RS14520 ENOG4108KQ5 Integrase catalytic subunit EJ357_RS14530 ENOG4108MRH transcriptional regulatory protein EJ357_RS14535 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJ357_RS14540 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EJ357_RS14555 ENOG4105SHT UspA domain-containing protein EJ357_RS14575 ENOG4108KK4 3-dehydroquinate synthase EJ357_RS14580 ENOG4108YUY EJ357_RS14595 ENOG41064E2 Xylose isomerase-like TIM barrel EJ357_RS14600 ENOG4107VXZ Hydrolase EJ357_RS14615 ENOG4105EQ2 LysR family Transcriptional regulator EJ357_RS14625 ENOG41064MX Tetr family transcriptional regulator EJ357_RS14635 ENOG4105F27 Major Facilitator EJ357_RS14680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS14685 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EJ357_RS14695 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EJ357_RS14705 ENOG4107GZ4 SanA protein EJ357_RS14730 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJ357_RS14755 ENOG4105KVH Transcriptional regulator EJ357_RS14775 ENOG4107QZF nitrite reductase NADPH large subunit EJ357_RS14785 ENOG4108IND Tetr family transcriptional regulator EJ357_RS14790 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJ357_RS14820 ENOG4105DHQ Histidine kinase EJ357_RS14825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS14830 ENOG4107B2H carbonic anhydrase EJ357_RS14835 ENOG4105CHH sulfate transporter EJ357_RS14845 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJ357_RS14850 ENOG4105E2R ROK family EJ357_RS14915 ENOG4105CPC Aldo Keto reductase EJ357_RS14930 ENOG410829K Lysine exporter protein (Lyse ygga) EJ357_RS14945 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) EJ357_RS14950 ENOG4105DSE periplasmic solute binding protein EJ357_RS14955 ENOG4105FDK ABC transporter EJ357_RS14970 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJ357_RS14975 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) EJ357_RS15035 ENOG41080E2 ribosomal-protein-alanine acetyltransferase EJ357_RS15060 ENOG4105NAF rna polymerase sigma factor EJ357_RS15075 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ357_RS15085 ENOG4105JXH GntR family transcriptional regulator EJ357_RS15090 ENOG4105DEF Extracellular solute-binding protein, family 5 EJ357_RS15100 ENOG4105C3U ABC transporter EJ357_RS15105 ENOG4108JQ7 (ABC) transporter EJ357_RS15115 ENOG4105W5A BNR Asp-box repeat protein EJ357_RS15120 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS15125 ENOG4105BZU Histidine kinase EJ357_RS15130 ENOG4105EYF MMPL domain protein EJ357_RS15145 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EJ357_RS15155 ENOG4105D4Y metalloprotease EJ357_RS15190 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EJ357_RS15215 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EJ357_RS15230 ENOG4105MSB protein, conserved in bacteria EJ357_RS15265 ENOG4105EQX glucarate dehydratase EJ357_RS15270 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EJ357_RS15275 ENOG4107HP6 Transcriptional regulator EJ357_RS15290 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJ357_RS15295 ENOG4107YU2 histidine triad (hIT) protein EJ357_RS15300 ENOG4107RE3 peptidase, S41 EJ357_RS15320 ENOG4107QWG 2-Nitropropane dioxygenase EJ357_RS15325 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EJ357_RS15330 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EJ357_RS15360 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EJ357_RS15370 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EJ357_RS15380 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EJ357_RS15405 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJ357_RS15415 ENOG4105EPR degv family EJ357_RS15425 ENOG4105C8T Leucyl-tRNA synthetase EJ357_RS15440 ENOG4107QIZ NADH dehydrogenase EJ357_RS15465 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ357_RS15470 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EJ357_RS15480 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EJ357_RS15485 ENOG4105D0M Protease HtpX homolog EJ357_RS15500 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EJ357_RS15510 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EJ357_RS15545 ENOG4105DGI Alkaline phosphatase EJ357_RS15565 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EJ357_RS15570 ENOG4105K46 50S ribosomal protein l27 EJ357_RS15575 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EJ357_RS15580 ENOG4105C03 ribonuclease EJ357_RS15625 ENOG4105CNI cell division protein FtsW EJ357_RS15630 ENOG4105CJN penicillin-binding protein EJ357_RS15645 ENOG4105DFF Rod shape-determining protein mreb EJ357_RS15650 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EJ357_RS15660 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EJ357_RS15665 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EJ357_RS15675 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EJ357_RS15680 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJ357_RS15685 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJ357_RS15690 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EJ357_RS15705 ENOG4108762 serine threonine protein kinase EJ357_RS15715 ENOG4108TGC Acyltransferase EJ357_RS15750 ENOG4105C85 amino acid EJ357_RS15770 ENOG4107ZYJ bioY protein EJ357_RS15775 ENOG4105E2R ROK family EJ357_RS15790 ENOG4105E2Y ABC, transporter EJ357_RS15805 ENOG4105C85 amino acid EJ357_RS15810 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ357_RS15820 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ357_RS15825 ENOG4105CMG Carbohydrate kinase EJ357_RS15830 ENOG4107VUR extracellular solute-binding protein EJ357_RS15845 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS15850 ENOG4108ZYE Transcriptional regulator EJ357_RS15860 ENOG4105D7V transposase EJ357_RS15875 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EJ357_RS15885 ENOG4105MC2 DSBA oxidoreductase EJ357_RS15975 ENOG4108KTG Membrane protein, drug metabolite transporter EJ357_RS15980 ENOG4108ZT1 Transcriptional regulator EJ357_RS15985 ENOG4107SCK Monooxygenase EJ357_RS16020 ENOG4105D8X mechanosensitive ion channel EJ357_RS16035 ENOG4108MP6 LysR family Transcriptional regulator EJ357_RS16045 ENOG4105E2R ROK family EJ357_RS16060 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJ357_RS16065 ENOG4105F8D glycoside hydrolase family 4 EJ357_RS16115 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EJ357_RS16120 ENOG4108Z18 K06886 hemoglobin EJ357_RS16260 ENOG4105VHU single-stranded DNA-binding protein EJ357_RS16265 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EJ357_RS16295 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EJ357_RS16310 ENOG41064MX Tetr family transcriptional regulator EJ357_RS16315 ENOG4108JQ1 Dehydrogenase EJ357_RS16370 ENOG4105JNK Glycosyl transferase (Group 1 EJ357_RS16375 ENOG4105D3Q Sugar transferase EJ357_RS16395 ENOG4105E2K Glycosyl transferase (Group 1 EJ357_RS16445 ENOG4105C26 Dehydrogenase EJ357_RS16450 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EJ357_RS16465 ENOG4105EDK PfkB domain protein EJ357_RS16470 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EJ357_RS16495 ENOG4107R13 MMPL domain protein EJ357_RS16520 ENOG4105C7H Helicase, RecD TraA family EJ357_RS16530 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS16535 ENOG4105C2J ABC transporter EJ357_RS16540 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJ357_RS16545 ENOG4108RVA ribokinase EJ357_RS16550 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EJ357_RS16605 ENOG4108YYQ gCN5-related N-acetyltransferase EJ357_RS16615 ENOG410645S MarR family Transcriptional regulator EJ357_RS16625 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase EJ357_RS16640 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EJ357_RS16645 ENOG4105D17 glycoside hydrolase, family 3 domain protein EJ357_RS16710 ENOG4105EDW glycosyl transferase, family 39 EJ357_RS16710 ENOG4105EDW glycosyl transferase, family 39 EJ357_RS16715 ENOG4108K8S endonuclease I EJ357_RS16725 ENOG4105C7K acetolactate synthase EJ357_RS16735 ENOG4105CK7 Sodium proline symporter EJ357_RS16745 ENOG4108XFF EJ357_RS16750 ENOG4107T5V SNARE associated Golgi EJ357_RS16755 ENOG4105C29 acyl-CoA thioesterase EJ357_RS16770 ENOG4107QX3 carboxylase EJ357_RS16780 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EJ357_RS16785 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS16805 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) EJ357_RS16815 ENOG4105DUU IucA IucC family protein EJ357_RS16820 ENOG4105E2D ec 3.2.1.52 EJ357_RS16840 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJ357_RS16850 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EJ357_RS16855 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS16880 ENOG4108XEP Alpha Beta Hydrolase Fold protein EJ357_RS16885 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS16920 ENOG4105BZU Histidine kinase EJ357_RS16925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS16950 ENOG4108ZM9 phosphoglycerate mutase EJ357_RS16995 ENOG4105BZU Histidine kinase EJ357_RS17000 ENOG4105DEN Luciferase family EJ357_RS17015 ENOG4105C5I Dehydrogenase EJ357_RS17060 ENOG4105J5T Amp-dependent synthetase and ligase EJ357_RS17070 ENOG4108M1A Chitin-binding protein EJ357_RS17105 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJ357_RS17140 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component EJ357_RS17150 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS17160 ENOG4105MWK D-amino acid dehydrogenase, small subunit EJ357_RS17165 ENOG41080U6 GntR family transcriptional regulator EJ357_RS17180 ENOG4105D9R oxidoreductase EJ357_RS17185 ENOG41090KN UPF0303 protein EJ357_RS17195 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJ357_RS17205 ENOG4108U4N (sortase) family EJ357_RS17220 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EJ357_RS17280 ENOG4105KF0 sporulation and cell division protein, SsgA EJ357_RS17320 ENOG4106BRA Membrane EJ357_RS17335 ENOG4108IUW ABC transporter EJ357_RS17350 ENOG4105BZ4 penicillin-binding protein EJ357_RS17380 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EJ357_RS17390 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EJ357_RS17410 ENOG4108RQ5 Beta-lactamase domain-containing protein EJ357_RS17435 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS17445 ENOG4105C85 amino acid EJ357_RS17455 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EJ357_RS17465 ENOG4108RWI nicotinamidase EJ357_RS17490 ENOG4105JVQ RNA Polymerase EJ357_RS17520 ENOG4105KF0 sporulation and cell division protein, SsgA EJ357_RS17525 ENOG4105CQB FAD linked oxidase domain protein EJ357_RS17555 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJ357_RS17565 ENOG4105E90 ABC transporter EJ357_RS17570 ENOG4108IJ8 ABC transporter EJ357_RS17575 ENOG4105E90 ABC transporter EJ357_RS17600 ENOG4105DTQ mandelate racemase muconate lactonizing EJ357_RS17620 ENOG41086VY Fic/DOC family EJ357_RS17675 ENOG4105E2D ec 3.2.1.52 EJ357_RS17685 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component EJ357_RS17700 ENOG4108UJU UPF0301 protein EJ357_RS17705 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJ357_RS17710 ENOG4108426 dNA-binding protein EJ357_RS17720 ENOG4105EEM helicase EJ357_RS17750 ENOG4105DQQ Major facilitator superfamily MFS_1 EJ357_RS17845 ENOG4106NZI LysR family Transcriptional regulator EJ357_RS17855 ENOG41068W2 Cytochrome p-450 EJ357_RS17890 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EJ357_RS17895 ENOG4105CN1 protease EJ357_RS17905 ENOG4105CAK Cell division ATP-binding protein ftsE EJ357_RS17920 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EJ357_RS17925 ENOG4108QVN serine threonine protein kinase EJ357_RS17930 ENOG4108UGD Serine Threonine protein kinase EJ357_RS17950 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EJ357_RS17955 ENOG4107SJB teichoic acid biosynthesis EJ357_RS17960 ENOG4107SJB teichoic acid biosynthesis EJ357_RS17965 ENOG4105K64 Glycosyl transferase, family 2 EJ357_RS17975 ENOG4108ZHJ Organic hydroperoxide resistance protein EJ357_RS17980 ENOG4105K56 Transcriptional regulator EJ357_RS18010 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS18025 ENOG4105EY8 ABC transporter EJ357_RS18030 ENOG4107SJB teichoic acid biosynthesis EJ357_RS18035 ENOG4105K64 Glycosyl transferase, family 2 EJ357_RS18045 ENOG4105C7I Dehydrogenase EJ357_RS18080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EJ357_RS18090 ENOG4105T0Z Conserved Protein EJ357_RS18095 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS18100 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea EJ357_RS18115 ENOG4105G3P Lipoprotein lpqB EJ357_RS18120 ENOG4105BZU Histidine kinase EJ357_RS18125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS18130 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EJ357_RS18145 ENOG4108WQ6 secreted protein EJ357_RS18150 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ357_RS18195 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EJ357_RS18200 ENOG4105DM4 PTS System EJ357_RS18205 ENOG4107QYR Signal peptidase i EJ357_RS18215 ENOG4105EIP mannose-6-phosphate isomerase EJ357_RS18225 ENOG4105W49 UPF0434 protein EJ357_RS18230 ENOG4107QKV phosphomannomutase EJ357_RS18235 ENOG4105DAA L-lactate EJ357_RS18255 ENOG4107RGC Glycosyl transferase, family 2 EJ357_RS18260 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJ357_RS18280 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) EJ357_RS18290 ENOG4107V9E glucose-1-phosphate thymidylyltransferase EJ357_RS18315 ENOG4108KGH TRANSCRIPTIONal EJ357_RS18320 ENOG4108KGH TRANSCRIPTIONal EJ357_RS18325 ENOG4108KGH TRANSCRIPTIONal EJ357_RS18345 ENOG4108KGH TRANSCRIPTIONal EJ357_RS18360 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJ357_RS18385 ENOG4108Z6Z Transcriptional regulator EJ357_RS18390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ357_RS18415 ENOG41065SU Two-component system sensor kinase EJ357_RS18420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS18425 ENOG4105DUX Transporter EJ357_RS18470 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EJ357_RS18480 ENOG41082AN stage II sporulation protein EJ357_RS18485 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS18495 ENOG4105CI2 imidazolone-5-propionate hydrolase EJ357_RS18510 ENOG4105CGP Urocanate hydratase EJ357_RS18555 ENOG4108IJ8 ABC transporter EJ357_RS18560 ENOG4105E90 ABC transporter EJ357_RS18565 ENOG4105E90 ABC transporter EJ357_RS18580 ENOG4108KEZ Dehydrogenase EJ357_RS18600 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS18640 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS18645 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS18650 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EJ357_RS18660 ENOG4105CEP NADH dehydrogenase EJ357_RS18685 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EJ357_RS18700 ENOG4106A3M Cytochrome p-450 EJ357_RS18775 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS18780 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS18785 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ357_RS18800 ENOG4107QN1 sodium solute EJ357_RS18835 ENOG4108ZGX Histidine kinase EJ357_RS18850 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EJ357_RS18855 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EJ357_RS18860 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EJ357_RS18865 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EJ357_RS18880 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EJ357_RS18890 ENOG41067SE Tetr family transcriptional regulator EJ357_RS18915 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EJ357_RS18920 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EJ357_RS18925 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS18935 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EJ357_RS18975 ENOG4105C5H ABC transporter EJ357_RS18980 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS18995 ENOG4105BZU Histidine kinase EJ357_RS19000 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EJ357_RS19005 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EJ357_RS19010 ENOG41069ER domain protein EJ357_RS19015 ENOG4105F8V Hydrolase, tatD family EJ357_RS19055 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) EJ357_RS19065 ENOG4108JJB ABC transporter EJ357_RS19070 ENOG4105K56 Transcriptional regulator EJ357_RS19075 ENOG4108ZHJ Organic hydroperoxide resistance protein EJ357_RS19090 ENOG4105K59 histidine triad (HIT) protein EJ357_RS19100 ENOG4105CQZ Histidine kinase EJ357_RS19120 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EJ357_RS19125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS19155 ENOG4105EYF MMPL domain protein EJ357_RS19175 ENOG4108BAS reductase EJ357_RS19180 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJ357_RS19185 ENOG4105F95 Monooxygenase EJ357_RS19195 ENOG4105CGK Exodeoxyribonuclease III EJ357_RS19220 ENOG4105D9U N-acetyltransferase EJ357_RS19225 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ357_RS19230 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ357_RS19240 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ357_RS19245 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase EJ357_RS19255 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) EJ357_RS19260 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ357_RS19270 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) EJ357_RS19280 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EJ357_RS19295 ENOG4105KXX peptidase s58 dmpa EJ357_RS19315 ENOG4105DM4 PTS System EJ357_RS19325 ENOG410804X Transcriptional regulator EJ357_RS19345 ENOG4108Z7F N-acetyltransferase EJ357_RS19350 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EJ357_RS19380 ENOG4107HP6 Transcriptional regulator EJ357_RS19400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EJ357_RS19415 ENOG4107ZVI PhiRv2 prophage protein EJ357_RS19500 ENOG4105VBF alkaline shock protein EJ357_RS19540 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJ357_RS19545 ENOG4105E1F short-chain dehydrogenase reductase EJ357_RS19555 ENOG4108KPJ rna polymerase sigma factor EJ357_RS19560 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJ357_RS19590 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS19600 ENOG4105DFW ABC transporter EJ357_RS19610 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EJ357_RS19635 ENOG4108V06 Glutathione peroxidase EJ357_RS19675 ENOG4105CHR reductase EJ357_RS19745 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) EJ357_RS19825 ENOG4105CG5 Glycosyl transferase (Group 1 EJ357_RS19830 ENOG4107SJB teichoic acid biosynthesis EJ357_RS19865 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS19890 ENOG4108762 serine threonine protein kinase EJ357_RS19905 ENOG4105F7P transcriptional regulator AsnC family EJ357_RS19910 ENOG4105N14 lysine exporter protein LysE YggA EJ357_RS19920 ENOG4105D2B acyl-CoA dehydrogenase EJ357_RS19945 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EJ357_RS19970 ENOG4105H3G oxidoreductase EJ357_RS19980 ENOG4106F1P AAA ATPase, central domain protein EJ357_RS20005 ENOG4108UKI Enoyl-CoA hydratase EJ357_RS20015 ENOG4105MXW flavin reductase domain protein, FMN-binding EJ357_RS20025 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EJ357_RS20045 ENOG4105D2S major facilitator superfamily EJ357_RS20065 ENOG4105CC9 acyl-Coa dehydrogenase EJ357_RS20090 ENOG4105D2B acyl-CoA dehydrogenase EJ357_RS20095 ENOG4105CC9 acyl-Coa dehydrogenase EJ357_RS20110 ENOG4105WN5 stage II sporulation protein EJ357_RS20165 ENOG4108XEP Alpha Beta Hydrolase Fold protein EJ357_RS20175 ENOG4108SU4 UPF0309 protein EJ357_RS20200 ENOG4108DT4 serine threonine protein kinase EJ357_RS20210 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EJ357_RS20230 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS20245 ENOG4107QX3 carboxylase EJ357_RS20260 ENOG4107AQZ Membrane EJ357_RS20270 ENOG4105CQB FAD linked oxidase domain protein EJ357_RS20275 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EJ357_RS20285 ENOG4106R7G Glycoside hydrolase family 5 EJ357_RS20370 ENOG4105CPC Aldo Keto reductase EJ357_RS20380 ENOG4105BZU Histidine kinase EJ357_RS20385 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS20420 ENOG4105C7N Xanthine uracil vitamin C permease EJ357_RS20430 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJ357_RS20470 ENOG4108N0W Major Facilitator superfamily EJ357_RS20480 ENOG4108UIH futalosine nucleosidase EJ357_RS20485 ENOG4105E63 Pfam:DUF178 EJ357_RS20490 ENOG4105VEQ Cold shock protein EJ357_RS20510 ENOG4105CVA phosphate EJ357_RS20525 ENOG4108TEB UPF0114 protein EJ357_RS20530 ENOG4105CFI type iii restriction protein res subunit EJ357_RS20540 ENOG4105EEM helicase EJ357_RS20575 ENOG4105KNA -acetyltransferase EJ357_RS20600 ENOG4105QEK Transcriptional regulator EJ357_RS20605 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EJ357_RS20610 ENOG4107S5I aldo keto reductase EJ357_RS20670 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EJ357_RS20690 ENOG4105C3Q Glycosyl transferase, family 2 EJ357_RS20720 ENOG4105CE4 GlcNAc 6-P deacetylase EJ357_RS20725 ENOG4105DE4 1-phosphofructokinase EJ357_RS20735 ENOG4105BZU Histidine kinase EJ357_RS20760 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EJ357_RS20830 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EJ357_RS20920 ENOG4105C2N RNA methyltransferase TrmH family group 3 EJ357_RS20925 ENOG4105C8N cysteinyl-tRNA synthetase EJ357_RS20930 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EJ357_RS20935 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EJ357_RS20945 ENOG4108VJ1 Transcriptional regulator (CarD family EJ357_RS20965 ENOG4105BZU Histidine kinase EJ357_RS21000 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ357_RS21025 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJ357_RS21045 ENOG4105TT9 Protein of unknown function (DUF2516) EJ357_RS21080 ENOG4108HMN Caspase domain EJ357_RS21120 ENOG4105ECP epimerase EJ357_RS21125 ENOG4105KVH Transcriptional regulator EJ357_RS21145 ENOG4105EEM helicase EJ357_RS21165 ENOG41080U6 GntR family transcriptional regulator EJ357_RS21200 ENOG4105HHS UPF0256 protein EJ357_RS21215 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EJ357_RS21225 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EJ357_RS21230 ENOG41090R7 Ferric uptake EJ357_RS21235 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands EJ357_RS21275 ENOG4105PKJ carbohydrate binding EJ357_RS21280 ENOG4105KHC sulfurtransferase EJ357_RS21310 ENOG4107NHD transcriptional regulator EJ357_RS21315 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS21320 ENOG4105C0H protease EJ357_RS21330 ENOG4105ETX regulatoR EJ357_RS21360 ENOG4105CGH 5'-nucleotidase EJ357_RS21365 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ357_RS21375 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS21380 ENOG4105CZV ABC transporter EJ357_RS21395 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EJ357_RS21425 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS21435 ENOG4105CJ3 phosphate transporter EJ357_RS21445 ENOG4105VPX protein, conserved in bacteria EJ357_RS21460 ENOG4105DNP FAD linked oxidase domain protein EJ357_RS21465 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EJ357_RS21470 ENOG4105K4H Nlp p60 protein EJ357_RS21505 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) EJ357_RS21510 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJ357_RS21595 ENOG4105CEP NADH dehydrogenase EJ357_RS21605 ENOG4105ESP cell wall surface anchor family protein EJ357_RS21630 ENOG4105D5U fad dependent oxidoreductase EJ357_RS21635 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EJ357_RS21675 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) EJ357_RS21685 ENOG41089UC methyltransferase, type 11 EJ357_RS21690 ENOG41082YX Transcriptional regulator, arsr family EJ357_RS21695 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJ357_RS21800 ENOG4105C1J atp-dependent rna helicase EJ357_RS21835 ENOG4105CQ7 ATP-dependent helicase EJ357_RS21855 ENOG4108TAC EJ357_RS21870 ENOG4105CXB phosphoribosylaminoimidazole synthetase EJ357_RS21935 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EJ357_RS21940 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EJ357_RS21945 ENOG410839H phosphoribosylformylglycinamidine synthase EJ357_RS21990 ENOG4105C8V SAICAR synthetase EJ357_RS22005 ENOG4105C12 Phosphoribosylglycinamide synthetase EJ357_RS22025 ENOG4107T65 Integrase EJ357_RS22030 ENOG4108NV9 Glycosyl Transferase EJ357_RS22035 ENOG4107QQG Dehydrogenase EJ357_RS22045 ENOG410836F Transposase EJ357_RS22070 ENOG410836F Transposase EJ357_RS22100 ENOG4107Y2X deaminase EJ357_RS22150 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 EJ357_RS22160 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJ357_RS22260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS22280 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJ357_RS22340 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EJ357_RS22355 ENOG4108Z6B deaminase EJ357_RS22370 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein EJ357_RS22375 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS22380 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS22405 ENOG4108YYC ycei family EJ357_RS22410 ENOG410905P Pyridoxamine 5-phosphate EJ357_RS22420 ENOG4105C57 major facilitator superfamily EJ357_RS22425 ENOG4105EDW glycosyl transferase, family 39 EJ357_RS22435 ENOG4105BZU Histidine kinase EJ357_RS22440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS22500 ENOG4105KVH Transcriptional regulator EJ357_RS22515 ENOG4108UAU isochorismatase EJ357_RS22520 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) EJ357_RS22740 ENOG4108UXN response regulator EJ357_RS22745 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS22750 ENOG4105NAF rna polymerase sigma factor EJ357_RS22795 ENOG4105D9P serine threonine protein kinase EJ357_RS22800 ENOG4105C0H protease EJ357_RS22820 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EJ357_RS22840 ENOG4107T6F Xaa-Pro aminopeptidase EJ357_RS22845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS22855 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase EJ357_RS22900 ENOG4105DBE peroxidase EJ357_RS22905 ENOG4105CQC Prephenate dehydratase EJ357_RS22910 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EJ357_RS22915 ENOG410667J hydrolase EJ357_RS22960 ENOG4107SWG transcriptional regulator MERR family EJ357_RS22965 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) EJ357_RS22975 ENOG410667J hydrolase EJ357_RS22980 ENOG4105E4C Lytic transglycosylase catalytic EJ357_RS22985 ENOG4108JJ9 ABC, transporter EJ357_RS22990 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJ357_RS22995 ENOG4105C4M (Ubiquinol oxidase) subunit I EJ357_RS23005 ENOG4105CIH Imidazole acetol-phosphate transaminase EJ357_RS23010 ENOG4107P2S Transcriptional regulator EJ357_RS23015 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EJ357_RS23025 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EJ357_RS23050 ENOG4106048 Cupin 2, conserved barrel domain protein EJ357_RS23055 ENOG41082T9 Membrane EJ357_RS23060 ENOG4105KJF protein tyrosine phosphatase EJ357_RS23065 ENOG4105C28 cystathionine EJ357_RS23100 ENOG4105F27 Major Facilitator EJ357_RS23120 ENOG4105CDU Replicative dna helicase EJ357_RS23130 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EJ357_RS23135 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EJ357_RS23140 ENOG4107YH6 single-stranded DNA-binding protein EJ357_RS23145 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) EJ357_RS23170 ENOG4105BZ4 penicillin-binding protein EJ357_RS23180 ENOG4105CZA synthase EJ357_RS23195 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EJ357_RS23210 ENOG4105D9P serine threonine protein kinase EJ357_RS23225 ENOG4105C3M thioredoxin reductase EJ357_RS23230 ENOG4105K63 Thioredoxin EJ357_RS23245 ENOG4107QJE Chromosome Partitioning Protein EJ357_RS23250 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EJ357_RS23260 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJ357_RS23265 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EJ357_RS23270 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EJ357_RS23280 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EJ357_RS23290 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJ357_RS23295 ENOG4108J5G 6-phosphogluconate dehydrogenase EJ357_RS23300 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EJ357_RS23305 ENOG4105K7N UPF0232 protein EJ357_RS23310 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ357_RS23315 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ357_RS23330 ENOG4105E2Y ABC, transporter EJ357_RS23350 ENOG4108UGD Serine Threonine protein kinase EJ357_RS23380 ENOG4105ZJT Cell division protein CrgA EJ357_RS23390 ENOG4108U4N (sortase) family EJ357_RS23405 ENOG4108U4N (sortase) family EJ357_RS23410 ENOG4108RN7 integral membrane protein EJ357_RS23430 ENOG4105CJN penicillin-binding protein EJ357_RS23445 ENOG4105HZM Fha domain containing protein EJ357_RS23450 ENOG4105TV9 FHA Domain-Containing protein EJ357_RS23475 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EJ357_RS23480 ENOG4105KVH Transcriptional regulator EJ357_RS23500 ENOG4108KC2 acyl-Coa dehydrogenase EJ357_RS23515 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase EJ357_RS23525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ357_RS23530 ENOG4108IG5 Transcriptional regulator EJ357_RS23550 ENOG4107QSN dihydrolipoamide acetyltransferase EJ357_RS23605 ENOG4107QPV Serine Threonine protein kinase EJ357_RS23620 ENOG4105CPP Dehydrogenase, E1 component EJ357_RS23625 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 EJ357_RS23675 ENOG4105DFM M18 family aminopeptidase EJ357_RS23680 ENOG4105CSU acyl-Coa dehydrogenase EJ357_RS23700 ENOG4105C57 major facilitator superfamily EJ357_RS23705 ENOG4105EUB pirin domain protein EJ357_RS23710 ENOG4105C02 permease EJ357_RS23720 ENOG4105C9M aspartyl-trna synthetase EJ357_RS23745 ENOG4105KWG Pfam:DUF1696 EJ357_RS23755 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJ357_RS23770 ENOG4108KXM LysR family Transcriptional regulator EJ357_RS23780 ENOG4105EM2 membrane EJ357_RS23795 ENOG4105F2Z 3-oxoadipate enol-lactonase EJ357_RS23800 ENOG4107SQD Transcriptional regulator, GntR family EJ357_RS23870 ENOG4108HMN Caspase domain EJ357_RS23900 ENOG4108PJD permease EJ357_RS23930 ENOG4108PYU two-component system response regulator EJ357_RS23935 ENOG4108FKE two-component system sensor kinase EJ357_RS23950 ENOG4105C22 threonyL-tRNA synthetase EJ357_RS23955 ENOG4105DU0 nucleoside hydrolase EJ357_RS23975 ENOG4105CG3 alpha amylase, catalytic region EJ357_RS24080 ENOG4105D9P serine threonine protein kinase EJ357_RS24110 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EJ357_RS24120 ENOG4105EYF MMPL domain protein EJ357_RS24125 ENOG4105BZU Histidine kinase EJ357_RS24150 ENOG4105CVP deoxyribo-dipyrimidine photolyase EJ357_RS24175 ENOG4105GTG Isochorismatase EJ357_RS24180 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJ357_RS24185 ENOG4105CXN decarboxylase EJ357_RS24195 ENOG4105BZ4 penicillin-binding protein EJ357_RS24205 ENOG4105EMN RNA polymerase sigma factor EJ357_RS24215 ENOG4108KPJ rna polymerase sigma factor EJ357_RS24245 ENOG4105VEQ Cold shock protein EJ357_RS24260 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS24295 ENOG4107UBC ErfK ybiS ycfS ynhG family protein EJ357_RS24310 ENOG4108KXV response regulator EJ357_RS24315 ENOG41065SU Two-component system sensor kinase EJ357_RS24370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJ357_RS24395 ENOG4105BZU Histidine kinase EJ357_RS24425 ENOG4105CHH sulfate transporter EJ357_RS24445 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EJ357_RS24455 ENOG4105EAD ABC transporter EJ357_RS24465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EJ357_RS24475 ENOG4105NAF rna polymerase sigma factor EJ357_RS24615 ENOG4105C0W non-ribosomal peptide synthetase EJ357_RS24650 ENOG4105C1J atp-dependent rna helicase EJ357_RS24655 ENOG4105VEQ Cold shock protein EJ357_RS24735 ENOG4108YRB methyltransferase EJ357_RS24770 ENOG4108HMN Caspase domain EJ357_RS24775 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS24790 ENOG4107QN1 sodium solute EJ357_RS24795 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS24815 ENOG4108KB2 LysR family Transcriptional regulator EJ357_RS24820 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EJ357_RS24860 ENOG4108HMN Caspase domain EJ357_RS24885 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A EJ357_RS24905 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJ357_RS24925 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A EJ357_RS24930 ENOG4108MUZ hydrolase EJ357_RS24935 ENOG4105J7D transcriptional regulator EJ357_RS24950 ENOG4105KNA -acetyltransferase EJ357_RS24965 ENOG4105DHP deoxycytidine triphosphate deaminase EJ357_RS25065 ENOG4105DF6 Fe-S oxidoreductase EJ357_RS25075 ENOG4105CFG Acts as a chaperone (By similarity) EJ357_RS25080 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EJ357_RS25085 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EJ357_RS25090 ENOG4105KNI merR family transcriptional Regulator EJ357_RS25110 ENOG4108S01 response regulator EJ357_RS25170 ENOG4105DFW ABC transporter EJ357_RS25220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EJ357_RS25255 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJ357_RS25275 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EJ357_RS25280 ENOG4107RCW fructose-bisphosphate aldolase EJ357_RS25305 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) EJ357_RS25330 ENOG4108ZGX Histidine kinase EJ357_RS25335 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS25340 ENOG4105BZU Histidine kinase EJ357_RS25345 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS25355 ENOG4106A3M Cytochrome p-450 EJ357_RS25365 ENOG4105DIM ABC transporter EJ357_RS25370 ENOG4105CIG ABC transporter EJ357_RS25390 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EJ357_RS25420 ENOG4105CKK Glycosyl transferase, family 2 EJ357_RS25425 ENOG4108WYP Transcriptional regulator EJ357_RS25430 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ357_RS25435 ENOG4108V4B ThiJ pfpI EJ357_RS25465 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EJ357_RS25470 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EJ357_RS25500 ENOG4105EB3 Histidine kinase EJ357_RS25520 ENOG4105CFH Aspartokinase EJ357_RS25530 ENOG4105NAF rna polymerase sigma factor EJ357_RS25560 ENOG4108PJD permease EJ357_RS25585 ENOG4108HMN Caspase domain EJ357_RS25630 ENOG4105BZ4 penicillin-binding protein EJ357_RS25660 ENOG4105KME endoribonuclease L-psp EJ357_RS25670 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJ357_RS25690 ENOG4105P8F nudix hydrolase EJ357_RS25705 ENOG4105D74 hydrolase EJ357_RS25720 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ357_RS25725 ENOG4105CHH sulfate transporter EJ357_RS25785 ENOG4108I5C dEAD DEAH box helicase EJ357_RS25790 ENOG4105WN5 stage II sporulation protein EJ357_RS25795 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EJ357_RS25800 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for EJ357_RS25820 ENOG4105CJ1 ABC, transporter EJ357_RS25835 ENOG4108UGD Serine Threonine protein kinase EJ357_RS25845 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EJ357_RS25850 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EJ357_RS25885 ENOG4105NCT RNA Polymerase EJ357_RS25895 ENOG4105CJ1 ABC, transporter EJ357_RS25925 ENOG4105C2M dna polymerase I EJ357_RS25950 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EJ357_RS25955 ENOG4105KDC 50s ribosomal protein l28 EJ357_RS25960 ENOG4105W0E 50S ribosomal protein L33 EJ357_RS25965 ENOG4105NRA 50s ribosomal protein l31 type b EJ357_RS25975 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EJ357_RS25995 ENOG4105C26 Dehydrogenase EJ357_RS26015 ENOG4105CVK Glutamate decarboxylase EJ357_RS26020 ENOG4107TXC Transcriptional regulator EJ357_RS26025 ENOG41082VC UPF0145 protein EJ357_RS26030 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN EJ357_RS26040 ENOG4105F0N pyrophosphate phospho-hydrolase EJ357_RS26055 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EJ357_RS26060 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJ357_RS26070 ENOG4105EUJ GTP cyclohydrolase i EJ357_RS26080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EJ357_RS26095 ENOG4105EEI dihydropteroate synthase EJ357_RS26100 ENOG4105CRK lysyL-tRNA synthetase EJ357_RS26125 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS26140 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS26145 ENOG4105I1F Resistance protein EJ357_RS26170 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EJ357_RS26175 ENOG4108IYU L-aspartate oxidase EJ357_RS26185 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EJ357_RS26235 ENOG4105DR5 peptidase EJ357_RS26240 ENOG4108IG5 Transcriptional regulator EJ357_RS26255 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EJ357_RS26260 ENOG4108FKE two-component system sensor kinase EJ357_RS26265 ENOG4108PYU two-component system response regulator EJ357_RS26270 ENOG41075QH Lipoprotein CseA EJ357_RS26275 ENOG4105NAF rna polymerase sigma factor EJ357_RS26285 ENOG4105BZU Histidine kinase EJ357_RS26310 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EJ357_RS26325 ENOG4108JWX EJ357_RS26330 ENOG4107R33 ppx gppa phosphatase EJ357_RS26335 ENOG4105EY0 Xylose isomerase domain protein TIM barrel EJ357_RS26340 ENOG4105XEA Tetr family transcriptional regulator EJ357_RS26345 ENOG4105C01 Dihydroxy-acid dehydratase EJ357_RS26355 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein EJ357_RS26365 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EJ357_RS26370 ENOG4105CJ1 ABC, transporter EJ357_RS26380 ENOG4105II7 pyrroline-5-carboxylate reductase EJ357_RS26385 ENOG4105C31 Tryptophanyl-tRNA synthetase EJ357_RS26410 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EJ357_RS26420 ENOG4106UW1 Major Facilitator superfamily EJ357_RS26425 ENOG4105DGU Histone deacetylase EJ357_RS26480 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EJ357_RS26485 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EJ357_RS26490 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EJ357_RS26495 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJ357_RS26535 ENOG4105D52 delta-aminolevulinic acid dehydratase EJ357_RS26545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS26570 ENOG4105C75 arginyL-tRNA synthetase EJ357_RS26575 ENOG4105DK7 lysyl-tRNA synthetase EJ357_RS26595 ENOG4105E0Y RtcB Protein EJ357_RS26610 ENOG4105KK4 UPF0060 membrane protein EJ357_RS26620 ENOG4105KVH Transcriptional regulator EJ357_RS26640 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJ357_RS26645 ENOG4108UZX fmn reductase EJ357_RS26655 ENOG41062D9 Histidine kinase EJ357_RS26660 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJ357_RS26695 ENOG4105CG3 alpha amylase, catalytic region EJ357_RS26710 ENOG4108KTG Membrane protein, drug metabolite transporter EJ357_RS26725 ENOG4108SGK Tetr family transcriptional regulator EJ357_RS26795 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EJ357_RS26800 ENOG4108RH7 phosphoglycerate mutase EJ357_RS26810 ENOG4107ZT5 Thiol disulfide interchange protein EJ357_RS26815 ENOG4107QIV Cytochrome c biogenesis protein EJ357_RS26820 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) EJ357_RS26825 ENOG4105CRE cytochrome C EJ357_RS26850 ENOG4108Z6Z Transcriptional regulator EJ357_RS26855 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ357_RS26865 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EJ357_RS26870 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EJ357_RS26885 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EJ357_RS26895 ENOG4105DVY radical SAM domain protein EJ357_RS26900 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EJ357_RS26925 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EJ357_RS26935 ENOG4105CHR reductase EJ357_RS27000 ENOG4105DFW ABC transporter EJ357_RS27015 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein EJ357_RS27020 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EJ357_RS27040 ENOG4108IMY Transcriptional regulator EJ357_RS27045 ENOG4105VEQ Cold shock protein EJ357_RS27050 ENOG4105EV6 Pfam:DUF178 EJ357_RS27065 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) EJ357_RS27090 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS27115 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJ357_RS27125 ENOG41068JE domain protein EJ357_RS27135 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27140 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ357_RS27145 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27155 ENOG4107QIZ NADH dehydrogenase EJ357_RS27160 ENOG4108IEH NADH dehydrogenase subunit g EJ357_RS27165 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EJ357_RS27170 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27175 ENOG41087XN oxidoreductase EJ357_RS27180 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27185 ENOG4105D65 subunit l EJ357_RS27195 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27200 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ357_RS27230 ENOG410667J hydrolase EJ357_RS27265 ENOG4105CJ1 ABC, transporter EJ357_RS27275 ENOG4108WS4 fmn reductase EJ357_RS27295 ENOG4105IIU Aminopeptidase EJ357_RS27310 ENOG4105ECR NmrA family EJ357_RS27315 ENOG4105KVH Transcriptional regulator EJ357_RS27335 ENOG4105DQU oxidoreductase, subunit beta EJ357_RS27340 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EJ357_RS27360 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ357_RS27365 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27370 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ357_RS27375 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EJ357_RS27380 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27385 ENOG4107YX3 NADH dehydrogenase subunit j EJ357_RS27390 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27395 ENOG4105D65 subunit l EJ357_RS27400 ENOG4105C8S subunit m EJ357_RS27405 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ357_RS27410 ENOG4105D0M Protease HtpX homolog EJ357_RS27415 ENOG410901E Membrane EJ357_RS27430 ENOG4105Y3U Transglycosylase-associated protein EJ357_RS27435 ENOG4108VPT UPF0234 protein EJ357_RS27475 ENOG4105WDJ 50S ribosomal protein L33 EJ357_RS27480 ENOG410900P UPF0336 protein EJ357_RS27505 ENOG4107R4N Cell wall formation (By similarity) EJ357_RS27520 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJ357_RS27535 ENOG410683Z Preprotein translocase SecE subunit EJ357_RS27540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EJ357_RS27550 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ357_RS27555 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EJ357_RS27565 ENOG4108VZM 50s ribosomal protein L10 EJ357_RS27580 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJ357_RS27585 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJ357_RS27600 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EJ357_RS27605 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EJ357_RS27610 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EJ357_RS27615 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EJ357_RS27625 ENOG4105D3Q Sugar transferase EJ357_RS27635 ENOG4105E2K Glycosyl transferase (Group 1 EJ357_RS27675 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EJ357_RS27685 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EJ357_RS27690 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EJ357_RS27695 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EJ357_RS27700 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EJ357_RS27705 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EJ357_RS27710 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EJ357_RS27715 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EJ357_RS27720 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EJ357_RS27725 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EJ357_RS27730 ENOG41082SA 50s ribosomal protein l29 EJ357_RS27735 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EJ357_RS27740 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EJ357_RS27745 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EJ357_RS27750 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EJ357_RS27755 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EJ357_RS27765 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EJ357_RS27770 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EJ357_RS27775 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EJ357_RS27780 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EJ357_RS27785 ENOG410849U 50S ribosomal protein L30 EJ357_RS27790 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EJ357_RS27795 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJ357_RS27800 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EJ357_RS27810 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EJ357_RS27815 ENOG41067V7 50S ribosomal protein L36 EJ357_RS27820 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EJ357_RS27825 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EJ357_RS27830 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJ357_RS27835 ENOG4108ZT0 50S ribosomal protein l17 EJ357_RS27840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EJ357_RS27860 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJ357_RS27880 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EJ357_RS27885 ENOG4108UJD 30S ribosomal protein S9 EJ357_RS27890 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EJ357_RS27905 ENOG4105CS9 pantothenic acid kinase EJ357_RS27930 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJ357_RS27940 ENOG4105MSY salicylate hydroxylase EJ357_RS27955 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EJ357_RS27965 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJ357_RS27970 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 EJ357_RS27975 ENOG4108097 ATP-binding protein EJ357_RS28000 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EJ357_RS28045 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJ357_RS28055 ENOG4108KGH TRANSCRIPTIONal EJ357_RS28085 ENOG4105CHP RNA polymerase EJ357_RS28110 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EJ357_RS28120 ENOG4105EMU Dehydrogenase EJ357_RS28125 ENOG4105DND Transcriptional regulator EJ357_RS28130 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJ357_RS28140 ENOG4108MMM RNA Polymerase EJ357_RS28150 ENOG4107QVP Dehydrogenase EJ357_RS28155 ENOG4107QQG Dehydrogenase EJ357_RS28160 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EJ357_RS28170 ENOG4108DT4 serine threonine protein kinase EJ357_RS28175 ENOG4105D9P serine threonine protein kinase EJ357_RS28180 ENOG4105D9P serine threonine protein kinase EJ357_RS28185 ENOG4105D9P serine threonine protein kinase EJ357_RS28190 ENOG4107TPY serine threonine protein kinase EJ357_RS28195 ENOG4108UGD Serine Threonine protein kinase EJ357_RS28200 ENOG4105C26 Dehydrogenase EJ357_RS28225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJ357_RS28275 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS28330 ENOG4105KKX ATPase associated with various cellular activities aaa_5 EJ357_RS28335 ENOG4105RD5 EJ357_RS28340 ENOG4105DEG Vwa containing coxe family protein EJ357_RS28360 ENOG4105CMV Succinyl-CoA synthetase subunit beta EJ357_RS28390 ENOG4105DC1 bifunctional purine biosynthesis protein purh EJ357_RS28395 ENOG4108762 serine threonine protein kinase EJ357_RS28430 ENOG4105D9P serine threonine protein kinase EJ357_RS28445 ENOG4105D9P serine threonine protein kinase EJ357_RS28460 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJ357_RS28480 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ357_RS28520 ENOG4108IJ7 Glycine betaine EJ357_RS28525 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component EJ357_RS28535 ENOG4105CR4 methylisocitrate lyase EJ357_RS28540 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJ357_RS28545 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJ357_RS28550 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS28580 ENOG4106032 Glutathionylspermidine synthase EJ357_RS28595 ENOG4105C8Y Acetylornithine aminotransferase EJ357_RS28600 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJ357_RS28620 ENOG4105EMN RNA polymerase sigma factor EJ357_RS28625 ENOG4105C31 Tryptophanyl-tRNA synthetase EJ357_RS28660 ENOG4107H3J ribonuclease EJ357_RS28675 ENOG4107RN3 metallophosphoesterase EJ357_RS28690 ENOG4105BZU Histidine kinase EJ357_RS28695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS28700 ENOG4105EYF MMPL domain protein EJ357_RS28705 ENOG4105U5Y Transcriptional regulator EJ357_RS28755 ENOG4108J01 L-aspartate oxidase EJ357_RS28775 ENOG4105E2D ec 3.2.1.52 EJ357_RS28855 ENOG4108MMM RNA Polymerase EJ357_RS28890 ENOG4105K64 Glycosyl transferase, family 2 EJ357_RS28910 ENOG4105K64 Glycosyl transferase, family 2 EJ357_RS28920 ENOG4105F0R Cytidylyltransferase EJ357_RS28925 ENOG4105D2T synthase EJ357_RS28935 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS28945 ENOG4108M6P methyltransferase EJ357_RS28950 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS28955 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ357_RS28965 ENOG4107RM1 amidohydrolase EJ357_RS28970 ENOG4105DIH basic membrane EJ357_RS28975 ENOG4105DIH basic membrane EJ357_RS28980 ENOG4108JQ9 ABC transporter EJ357_RS29030 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJ357_RS29040 ENOG4107RSM transcriptional regulator EJ357_RS29045 ENOG4105D94 Major Facilitator Superfamily EJ357_RS29065 ENOG41065SU Two-component system sensor kinase EJ357_RS29070 ENOG4108KXV response regulator EJ357_RS29075 ENOG4105NAF rna polymerase sigma factor EJ357_RS29095 ENOG4105C26 Dehydrogenase EJ357_RS29100 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EJ357_RS29120 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain EJ357_RS29155 ENOG4108JIK carboxylase EJ357_RS29165 ENOG4107WR6 Maf-like protein EJ357_RS29180 ENOG4105D8K carboxyl transferase EJ357_RS29190 ENOG4108QER Adenylate cyclase EJ357_RS29200 ENOG4105E39 Enoyl-CoA hydratase EJ357_RS29205 ENOG4105KDM Diguanylate cyclase with gaf sensor EJ357_RS29215 ENOG4105C84 Histidine ammonia-lyase EJ357_RS29245 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS29270 ENOG4105DQ4 alcohol dehydrogenase EJ357_RS29285 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EJ357_RS29300 ENOG4105D0M Protease HtpX homolog EJ357_RS29320 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EJ357_RS29325 ENOG4105C7B Threonine dehydratase EJ357_RS29340 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EJ357_RS29350 ENOG4105T1M mycothiol conjugate amidase mca EJ357_RS29370 ENOG4105C7Z Conserved Protein EJ357_RS29405 ENOG4105C57 major facilitator superfamily EJ357_RS29415 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) EJ357_RS29450 ENOG4105CHM Aminotransferase EJ357_RS29480 ENOG4108FUF Transcriptional regulator, IclR family EJ357_RS29485 ENOG4105KME endoribonuclease L-psp EJ357_RS29490 ENOG4105C6Z Gluconate EJ357_RS29595 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS29615 ENOG4107QKZ Ompa motb domain protein EJ357_RS29640 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJ357_RS29645 ENOG4108IAB Phoh family EJ357_RS29660 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJ357_RS29665 ENOG4105D3R alkyl hydroperoxide reductase EJ357_RS29695 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJ357_RS29715 ENOG4105BZ4 penicillin-binding protein EJ357_RS29730 ENOG4105C9Q fumarate hydratase class II EJ357_RS29735 ENOG4107GFK fumarate EJ357_RS29760 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) EJ357_RS29765 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EJ357_RS29775 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EJ357_RS29780 ENOG4105DFK Polyphosphate glucokinase EJ357_RS29790 ENOG4105C3G gtp-binding protein EJ357_RS29825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ357_RS29830 ENOG4105CHR reductase EJ357_RS29860 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS29875 ENOG41081E8 Alpha beta hydrolase EJ357_RS29890 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) EJ357_RS29905 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJ357_RS29910 ENOG4105C57 major facilitator superfamily EJ357_RS29950 ENOG4105EYF MMPL domain protein EJ357_RS29960 ENOG4105DTD Dehydrogenase EJ357_RS29965 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EJ357_RS29970 ENOG4105CZS beta-ketoacyl synthase EJ357_RS29975 ENOG4106ARF phosphopantetheine-binding protein EJ357_RS29990 ENOG4105MXW flavin reductase domain protein, FMN-binding EJ357_RS29995 ENOG4105D8K carboxyl transferase EJ357_RS30045 ENOG4106NZI LysR family Transcriptional regulator EJ357_RS30050 ENOG4105E1F short-chain dehydrogenase reductase EJ357_RS30065 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS30110 ENOG4105E33 succinate dehydrogenase EJ357_RS30115 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EJ357_RS30165 ENOG4105CI3 gtp-binding protein typa EJ357_RS30170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS30175 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ357_RS30190 ENOG4108JQ7 (ABC) transporter EJ357_RS30195 ENOG4108JQ7 (ABC) transporter EJ357_RS30200 ENOG4105C3U ABC transporter EJ357_RS30205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS30210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJ357_RS30215 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EJ357_RS30235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJ357_RS30240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS30250 ENOG4108JQ7 (ABC) transporter EJ357_RS30305 ENOG4108Z4U Ferredoxin EJ357_RS30325 ENOG4107R4C succinyl-diaminopimelate desuccinylase EJ357_RS30330 ENOG4108URH decarboxylase EJ357_RS30335 ENOG4105EEI dihydropteroate synthase EJ357_RS30345 ENOG4108R3E Dna-3-methyladenine glycosylase i EJ357_RS30350 ENOG4105CGU Enoyl-CoA hydratase EJ357_RS30365 ENOG4105DU6 RNA polymerase EJ357_RS30375 ENOG4105C0H protease EJ357_RS30380 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EJ357_RS30415 ENOG4105D7N magnesium and cobalt transport protein CorA EJ357_RS30425 ENOG4105DXB Major Facilitator superfamily EJ357_RS30440 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EJ357_RS30460 ENOG4105C1J atp-dependent rna helicase EJ357_RS30515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS30525 ENOG4108JQ6 ABC transporter EJ357_RS30555 ENOG4106JDR secreted EJ357_RS30580 ENOG4105C4R Atp-dependent dna helicase EJ357_RS30585 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJ357_RS30615 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJ357_RS30630 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EJ357_RS30680 ENOG41063PX domain protein EJ357_RS30690 ENOG4105DJZ UPF0182 protein EJ357_RS30735 ENOG4107TK4 histidinol-phosphate phosphatase EJ357_RS30760 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EJ357_RS30770 ENOG4108RAV Conserved protein EJ357_RS30780 ENOG4105EMN RNA polymerase sigma factor EJ357_RS30785 ENOG4105WMN AntiSigma factor EJ357_RS30790 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EJ357_RS30805 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJ357_RS30815 ENOG41068W2 Cytochrome p-450 EJ357_RS30820 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS30830 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ357_RS30835 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ357_RS30865 ENOG4105D22 carbon starvation protein EJ357_RS30870 ENOG4105FDP GntR family transcriptional regulator EJ357_RS30890 ENOG4105D17 glycoside hydrolase, family 3 domain protein EJ357_RS30895 ENOG4105VZ8 Transcriptional regulator EJ357_RS30905 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EJ357_RS30910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJ357_RS30915 ENOG4105CHR reductase EJ357_RS30935 ENOG4105CBD Diacylglycerol kinase EJ357_RS30965 ENOG4105K6H D-cysteine desulfhydrase EJ357_RS30975 ENOG4105ESN nucleotide-binding protein EJ357_RS31010 ENOG4105CHP RNA polymerase EJ357_RS31045 ENOG4108ME1 Peptidase M55 D-aminopeptidase EJ357_RS31125 ENOG4107ZVI PhiRv2 prophage protein EJ357_RS31140 ENOG4105VTR Integrase EJ357_RS31145 ENOG4108VEQ Superoxide dismutase EJ357_RS31160 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ357_RS31165 ENOG4105CDA abc transporter atp-binding protein EJ357_RS31185 ENOG4105C6K Malic enzyme EJ357_RS31190 ENOG4105CB2 alcohol dehydrogenase EJ357_RS31230 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EJ357_RS31235 ENOG4105EB3 Histidine kinase EJ357_RS31240 ENOG4108PYU two-component system response regulator EJ357_RS31260 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EJ357_RS31305 ENOG4105K4H Nlp p60 protein EJ357_RS31350 ENOG4105CJN penicillin-binding protein EJ357_RS31355 ENOG4107QHZ cell cycle protein EJ357_RS31365 ENOG4108FKE two-component system sensor kinase EJ357_RS31385 ENOG4105DQE DNA ligase EJ357_RS31390 ENOG4105FDF Could be involved in DNA repair (By similarity) EJ357_RS31395 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EJ357_RS31435 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) EJ357_RS31490 ENOG4105C75 arginyL-tRNA synthetase EJ357_RS31495 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJ357_RS31500 ENOG4105D6E homoserine dehydrogenase EJ357_RS31505 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EJ357_RS31510 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EJ357_RS31520 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJ357_RS31525 ENOG4108RCF TRANSCRIPTIONal EJ357_RS31530 ENOG4105VFB Binds the 23S rRNA (By similarity) EJ357_RS31535 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EJ357_RS31540 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJ357_RS31550 ENOG4107ZF2 Phosphatase EJ357_RS31555 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJ357_RS31565 ENOG4105ESV Glycosyl transferase, family 4 EJ357_RS31570 ENOG4105Z3P ATP synthase EJ357_RS31580 ENOG4105ZA1 atp synthase EJ357_RS31585 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) EJ357_RS31590 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EJ357_RS31595 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EJ357_RS31600 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EJ357_RS31605 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EJ357_RS31610 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EJ357_RS31625 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS31630 ENOG4105BZU Histidine kinase EJ357_RS31635 ENOG4105IIP Membrane EJ357_RS31645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ357_RS31660 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) EJ357_RS31720 ENOG4108ZVT methylmalonyl-coA epimerase EJ357_RS31725 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS31745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS31820 ENOG4105KHM amidohydrolase 2 EJ357_RS31830 ENOG4106A3M Cytochrome p-450 EJ357_RS31835 ENOG4105PEJ SchA CurD domain protein EJ357_RS31845 ENOG4105WX6 Membrane EJ357_RS31910 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EJ357_RS31915 ENOG4105C6K Malic enzyme EJ357_RS31920 ENOG4105CTQ phosphohexokinase EJ357_RS31940 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EJ357_RS31945 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EJ357_RS31980 ENOG4108MRH transcriptional regulatory protein EJ357_RS31990 ENOG4107QJT sodium dicarboxylate symporter EJ357_RS32010 ENOG4108FN7 Aldo keto reductase EJ357_RS32030 ENOG4105C3M thioredoxin reductase EJ357_RS32040 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EJ357_RS32045 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) EJ357_RS32055 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) EJ357_RS32060 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS32065 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EJ357_RS32090 ENOG4105BZ1 (ABC) transporter EJ357_RS32095 ENOG4105BZ1 (ABC) transporter EJ357_RS32100 ENOG4105BZ1 (ABC) transporter EJ357_RS32105 ENOG4105BZ1 (ABC) transporter EJ357_RS32110 ENOG4105CJ1 ABC, transporter EJ357_RS32120 ENOG4105BZU Histidine kinase EJ357_RS32125 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS32130 ENOG41061MV Arylsulfatase EJ357_RS32140 ENOG4107UBC ErfK ybiS ycfS ynhG family protein EJ357_RS32195 ENOG4107YXZ hydrolase, family 25 EJ357_RS32220 ENOG4105EJQ L-serine dehydratase EJ357_RS32225 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJ357_RS32230 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EJ357_RS32235 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EJ357_RS32255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS32260 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ357_RS32275 ENOG4108JQ7 (ABC) transporter EJ357_RS32280 ENOG4105EN6 Membrane EJ357_RS32320 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EJ357_RS32325 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EJ357_RS32340 ENOG4108URH decarboxylase EJ357_RS32345 ENOG4105EMU Dehydrogenase EJ357_RS32360 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJ357_RS32365 ENOG4105BZU Histidine kinase EJ357_RS32370 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EJ357_RS32375 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ357_RS32385 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EJ357_RS32400 ENOG4105EYF MMPL domain protein EJ357_RS32405 ENOG4105D9U N-acetyltransferase EJ357_RS32420 ENOG4107SM8 Adenylate Guanylate cyclase EJ357_RS32435 ENOG4105CPC Aldo Keto reductase EJ357_RS32455 ENOG4108ZP8 Acetolactate synthase small subunit EJ357_RS32460 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJ357_RS32470 ENOG4105C57 major facilitator superfamily EJ357_RS32480 ENOG4108JQ7 (ABC) transporter EJ357_RS32490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS32505 ENOG4107YHD transcriptional regulator EJ357_RS32510 ENOG41062BK proline dehydrogenase EJ357_RS32515 ENOG4105C26 Dehydrogenase EJ357_RS32535 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EJ357_RS32540 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJ357_RS32570 ENOG4105CQM Urea amidohydrolase subunit alpha EJ357_RS32575 ENOG4105DWY Agmatine deiminase EJ357_RS32595 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EJ357_RS32620 ENOG4105DJ2 Major Facilitator Superfamily EJ357_RS32650 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJ357_RS32670 ENOG4108YYC ycei family EJ357_RS32675 ENOG4106AM8 polysaccharide lyase family 8 EJ357_RS32680 ENOG4105D8K carboxyl transferase EJ357_RS32700 ENOG4105GWZ Roadblock lc7 family protein EJ357_RS32720 ENOG4105GWZ Roadblock lc7 family protein EJ357_RS32735 ENOG4105ERH Fumarylacetoacetate hydrolase EJ357_RS32740 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EJ357_RS32785 ENOG41069M3 Transcriptional regulator EJ357_RS32790 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EJ357_RS32795 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EJ357_RS32805 ENOG4105K70 DNA-binding protein EJ357_RS32825 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EJ357_RS32830 ENOG4105CPF Cell wall formation (By similarity) EJ357_RS32850 ENOG4105DWF phosphomethylpyrimidine kinase EJ357_RS32855 ENOG4105VB9 50S ribosomal protein l28 EJ357_RS32880 ENOG4106H78 methyltransferase EJ357_RS32885 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EJ357_RS32900 ENOG41084BZ 50S ribosomal protein L32 EJ357_RS32905 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EJ357_RS32910 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EJ357_RS32915 ENOG4105KVH Transcriptional regulator EJ357_RS32920 ENOG4105K4I Scp-like extracellular EJ357_RS32925 ENOG4108375 Acylphosphatase (EC 3.6.1.7) EJ357_RS32940 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EJ357_RS32985 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EJ357_RS32995 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EJ357_RS33005 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) EJ357_RS33015 ENOG4105K5M 30s ribosomal protein S16 EJ357_RS33020 ENOG41082KU UPF0109 protein EJ357_RS33025 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EJ357_RS33030 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EJ357_RS33035 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EJ357_RS33050 ENOG4107QYR Signal peptidase i EJ357_RS33055 ENOG4107QYR Signal peptidase i EJ357_RS33070 ENOG41080R2 UPF0102 protein EJ357_RS33105 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS33120 ENOG4105CE9 30S ribosomal protein S2 EJ357_RS33125 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EJ357_RS33130 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJ357_RS33135 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EJ357_RS33140 ENOG4105KNE Phosphatidate cytidylyltransferase EJ357_RS33150 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EJ357_RS33160 ENOG4108I5D sulfate abc transporter EJ357_RS33165 ENOG4108UCS ABC, transporter EJ357_RS33195 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJ357_RS33200 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ357_RS33210 ENOG4105C26 Dehydrogenase EJ357_RS33265 ENOG4105KVH Transcriptional regulator EJ357_RS33275 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ357_RS33280 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJ357_RS33305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS33310 ENOG4105F38 ABC transporter, permease EJ357_RS33315 ENOG4105D38 putrescine abc transporter EJ357_RS33320 ENOG4105CJP fad dependent oxidoreductase EJ357_RS33385 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EJ357_RS33415 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJ357_RS33420 ENOG4105DZP Membrane-associated zinc metalloprotease EJ357_RS33425 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EJ357_RS33440 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EJ357_RS33475 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase EJ357_RS33495 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) EJ357_RS33510 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EJ357_RS33520 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EJ357_RS33525 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EJ357_RS33590 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS33750 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS33820 ENOG4105EC2 ftsk spoIIIe EJ357_RS33830 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EJ357_RS33835 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EJ357_RS33840 ENOG4105C1V Peptidase, M16 EJ357_RS33845 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EJ357_RS33870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ357_RS33875 ENOG4105CN5 Metallo-Beta-Lactamase EJ357_RS33920 ENOG4105BZU Histidine kinase EJ357_RS33925 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EJ357_RS33930 ENOG4107QZI cell division protein FtsK EJ357_RS33940 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EJ357_RS33950 ENOG4105CEV competence damage-inducible protein EJ357_RS33955 ENOG4105WBV Transcriptional regulator EJ357_RS33965 ENOG4105CHR reductase EJ357_RS33970 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) EJ357_RS33975 ENOG4107QRT dEAD DEAH box helicase EJ357_RS33980 ENOG4106AXJ AraC family transcriptional regulator EJ357_RS34005 ENOG4105DSF transport protein EJ357_RS34010 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EJ357_RS34040 ENOG4105DRP amino acid AbC transporter EJ357_RS34045 ENOG4108Q1T ABC transporter EJ357_RS34050 ENOG4107UBR Extracellular solute-binding protein family 3 EJ357_RS34055 ENOG4105CDA abc transporter atp-binding protein EJ357_RS34060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS34065 ENOG4105EB3 Histidine kinase EJ357_RS34070 ENOG4105H1G trap transporter solute receptor taxi family EJ357_RS34085 ENOG4106A3M Cytochrome p-450 EJ357_RS34120 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJ357_RS34140 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EJ357_RS34150 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EJ357_RS34155 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJ357_RS34165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJ357_RS34200 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EJ357_RS34205 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EJ357_RS34210 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ357_RS34225 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ357_RS34250 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJ357_RS34265 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ357_RS34285 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EJ357_RS34295 ENOG4105DRR Transcriptional regulator, GntR family EJ357_RS34300 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS34315 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ357_RS34325 ENOG4107QN1 sodium solute EJ357_RS34330 ENOG4108MRH transcriptional regulatory protein EJ357_RS34345 ENOG4105BZN citrate synthase EJ357_RS34350 ENOG4105BZN citrate synthase EJ357_RS34365 ENOG4105CKI cobalamin synthesis protein EJ357_RS34370 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ357_RS34395 ENOG4105DRR Transcriptional regulator, GntR family EJ357_RS34400 ENOG410849S phosphocarrier protein (HPr) EJ357_RS34425 ENOG4107W53 thymidine kinase EJ357_RS34455 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EJ357_RS34465 ENOG4105F44 Two component transcriptional regulator, winged helix family EJ357_RS34470 ENOG4106F60 Histidine kinase EJ357_RS34495 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EJ357_RS34535 ENOG4107VEG TrkA-N domain protein EJ357_RS34540 ENOG4105C0X amino acid EJ357_RS34545 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EJ357_RS34570 ENOG41082SX arsR family transcriptional regulator EJ357_RS34575 ENOG4105BZU Histidine kinase EJ357_RS34580 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS34600 ENOG4105CT3 Monooxygenase EJ357_RS34625 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJ357_RS34640 ENOG4105E2A Dehydrogenase EJ357_RS34740 ENOG4105D8K carboxyl transferase EJ357_RS34770 ENOG4105CZS beta-ketoacyl synthase EJ357_RS34790 ENOG4108JIK carboxylase EJ357_RS34795 ENOG4108Z4X TRANSCRIPTIONal EJ357_RS34805 ENOG4105KVH Transcriptional regulator EJ357_RS34815 ENOG4108KQ5 Integrase catalytic subunit EJ357_RS34850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ357_RS34855 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EJ357_RS34860 ENOG4105ERH Fumarylacetoacetate hydrolase EJ357_RS34885 ENOG4105C57 major facilitator superfamily EJ357_RS34925 ENOG4105CPF Cell wall formation (By similarity) EJ357_RS34965 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJ357_RS35010 ENOG4107S1Q Phosphatase EJ357_RS35025 ENOG4105CEU Arginine dihydrolase EJ357_RS35030 ENOG4105DBV ornithine carbamoyltransferase EJ357_RS35040 ENOG4105CGU Enoyl-CoA hydratase EJ357_RS35135 ENOG4107QTZ amino acid EJ357_RS35190 ENOG4105C57 major facilitator superfamily EJ357_RS35205 ENOG4105C8Y Acetylornithine aminotransferase EJ357_RS35210 ENOG4105C8Y Acetylornithine aminotransferase EJ357_RS35240 ENOG41062JF Transcriptional regulator EJ357_RS35270 ENOG4106A3M Cytochrome p-450 EJ357_RS35330 ENOG4105F1A Pyruvate formate-lyase EJ357_RS35340 ENOG4106F1P AAA ATPase, central domain protein EJ357_RS35365 ENOG4105C4R Atp-dependent dna helicase EJ357_RS35375 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 EJ357_RS35410 ENOG4105CFG Acts as a chaperone (By similarity) EJ357_RS35460 ENOG4105CVR type I restriction-modification system EJ357_RS35470 ENOG4105D9P serine threonine protein kinase EJ357_RS35485 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJ357_RS35500 ENOG4105CDH Citrulline--aspartate ligase EJ357_RS35505 ENOG4107QM5 aconitate hydratase EJ357_RS35515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS35530 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) EJ357_RS35540 ENOG4105I82 acetyl xylan esterase EJ357_RS35550 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EJ357_RS35590 ENOG4105D7V transposase EJ357_RS35600 ENOG4105E2R ROK family EJ357_RS35605 ENOG4105DFW ABC transporter EJ357_RS35610 ENOG4105C2J ABC transporter EJ357_RS35615 ENOG4108HWW ABC transporter EJ357_RS35620 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EJ357_RS35625 ENOG4105CUB amino acid EJ357_RS35640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJ357_RS35655 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ357_RS35660 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS35675 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EJ357_RS35690 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EJ357_RS35705 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EJ357_RS35720 ENOG4107JTW chlorite dismutase EJ357_RS35740 ENOG4105E18 UPF0276 protein EJ357_RS35750 ENOG4108IUX (ABC) transporter EJ357_RS35790 ENOG4107B2H carbonic anhydrase EJ357_RS35820 ENOG4105DFU Cell wall formation (By similarity) EJ357_RS35825 ENOG4105E0X reductase EJ357_RS35880 ENOG4105D17 glycoside hydrolase, family 3 domain protein EJ357_RS35895 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJ357_RS35900 ENOG4105DRS transport system, permease EJ357_RS35925 ENOG4105QEK Transcriptional regulator EJ357_RS35930 ENOG4108SU4 UPF0309 protein EJ357_RS35945 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJ357_RS35950 ENOG4105F6J Alpha beta hydrolase fold EJ357_RS35975 ENOG410880H cysteine synthase EJ357_RS35980 ENOG4105DIA mandelate racemase muconate lactonizing EJ357_RS35995 ENOG4105DEF Extracellular solute-binding protein, family 5 EJ357_RS36005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS36010 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS36020 ENOG4105BZU Histidine kinase EJ357_RS36025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS36040 ENOG4105CJ2 (LipO)protein EJ357_RS36050 ENOG4108IJ8 ABC transporter EJ357_RS36055 ENOG4105E90 ABC transporter EJ357_RS36060 ENOG4105E90 ABC transporter EJ357_RS36080 ENOG4105GWZ Roadblock lc7 family protein EJ357_RS36150 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS36155 ENOG41064MX Tetr family transcriptional regulator EJ357_RS36165 ENOG41064MX Tetr family transcriptional regulator EJ357_RS36200 ENOG4105D7T ABC transporter EJ357_RS36210 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein EJ357_RS36225 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EJ357_RS36270 ENOG4105ZSU inhibitor EJ357_RS36390 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJ357_RS36435 ENOG4105GSW EJ357_RS36465 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EJ357_RS36480 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ357_RS36490 ENOG4107RR1 TRANSCRIPTIONal EJ357_RS36495 ENOG4105CSU acyl-Coa dehydrogenase EJ357_RS36555 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS36570 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS36580 ENOG4105EBR Carboxylesterase EJ357_RS36600 ENOG41061WM D-Alanyl-D-Alanine EJ357_RS36610 ENOG4108J5H Homocysteine s-methyltransferase EJ357_RS36615 ENOG4105D5Q Arginine ornithine antiporter EJ357_RS36650 ENOG4107TDE lipolytic protein G-D-S-L family EJ357_RS36735 ENOG4105CJ1 ABC, transporter EJ357_RS36745 ENOG4105DRS transport system, permease EJ357_RS36765 ENOG4105QE3 oxidoreductase EJ357_RS36780 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJ357_RS36785 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EJ357_RS36795 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ357_RS36845 ENOG4105DRR Transcriptional regulator, GntR family EJ357_RS36870 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EJ357_RS36875 ENOG4105C7N Xanthine uracil vitamin C permease EJ357_RS36910 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) EJ357_RS36915 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) EJ357_RS36975 ENOG41061H0 Monooxygenase EJ357_RS37055 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EJ357_RS37060 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EJ357_RS37080 ENOG4105EQQ protein containing aminopeptidase domain EJ357_RS37085 ENOG4105CMR udp-glucose 4-epimerase EJ357_RS37095 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EJ357_RS37105 ENOG4105E2K Glycosyl transferase (Group 1 EJ357_RS37125 ENOG4107RRD Dehydrogenase EJ357_RS37130 ENOG4105CAQ asparagine synthetase EJ357_RS37150 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJ357_RS37195 ENOG4107HP6 Transcriptional regulator EJ357_RS37200 ENOG4107HP6 Transcriptional regulator EJ357_RS37210 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ357_RS37215 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJ357_RS37250 ENOG4107RQ0 Maleylacetate reductase EJ357_RS37260 ENOG4108KC1 acyl-Coa dehydrogenase EJ357_RS37310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS37315 ENOG4105BZU Histidine kinase EJ357_RS37320 ENOG4105CMR udp-glucose 4-epimerase EJ357_RS37335 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS37340 ENOG4105C2J ABC transporter EJ357_RS37345 ENOG4105CNN ABC, transporter EJ357_RS37350 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator EJ357_RS37365 ENOG4105D7N magnesium and cobalt transport protein CorA EJ357_RS37375 ENOG410829K Lysine exporter protein (Lyse ygga) EJ357_RS37380 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJ357_RS37400 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS37405 ENOG4105XYF acetyltransferase EJ357_RS37415 ENOG41060W2 glyoxylate carboligase EJ357_RS37420 ENOG4105CH6 catalase EJ357_RS37425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJ357_RS37430 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EJ357_RS37445 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EJ357_RS37455 ENOG4105DPX Hydrogenase, large subunit EJ357_RS37485 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) EJ357_RS37495 ENOG4105C8H hydrogenase maturation protein Hypf EJ357_RS37505 ENOG4105CQS hydrogenase expression formation protein HypD EJ357_RS37530 ENOG4105VT2 5-hydroxyisourate hydrolase EJ357_RS37540 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS37565 ENOG4105KVH Transcriptional regulator EJ357_RS37580 ENOG4108ZM9 phosphoglycerate mutase EJ357_RS37585 ENOG4107R13 MMPL domain protein EJ357_RS37590 ENOG4107EEY synthase EJ357_RS37595 ENOG4105CHM Aminotransferase EJ357_RS37615 ENOG4105DUU IucA IucC family protein EJ357_RS37635 ENOG4107R9S Malate synthase EJ357_RS37655 ENOG4107HP6 Transcriptional regulator EJ357_RS37665 ENOG4105DHG Allantoate amidinohydrolase EJ357_RS37670 ENOG4105F6U Short-chain dehydrogenase reductase Sdr EJ357_RS37700 ENOG4105C5F glutamine synthetase EJ357_RS37715 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) EJ357_RS37755 ENOG4105C26 Dehydrogenase EJ357_RS37760 ENOG4108Z86 Glutamine amidotransferase EJ357_RS37770 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJ357_RS37780 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EJ357_RS37815 ENOG4105CS1 NAD(P)H quinone oxidoreductase EJ357_RS37835 ENOG4105GVJ transcriptional regulator EJ357_RS37850 ENOG4105F9F transposase EJ357_RS37890 ENOG4108KQ5 Integrase catalytic subunit EJ357_RS37920 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS37930 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EJ357_RS37940 ENOG4105DKQ ROK family EJ357_RS37950 ENOG4105C0D helicase EJ357_RS37965 ENOG4105NPE arsR family transcriptional regulator EJ357_RS37990 ENOG4108R5S membrane EJ357_RS38090 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ357_RS38095 ENOG4107RBB ABC transporter, permease EJ357_RS38100 ENOG4105DR5 peptidase EJ357_RS38170 ENOG4105EYF MMPL domain protein EJ357_RS38175 ENOG4108ZX5 transcriptional regulator EJ357_RS38185 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJ357_RS38220 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EJ357_RS38225 ENOG4105DE4 1-phosphofructokinase EJ357_RS38230 ENOG4105C26 Dehydrogenase EJ357_RS38250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EJ357_RS38255 ENOG4105E8R UPF0173 metal-dependent hydrolase EJ357_RS38285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EJ357_RS38290 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EJ357_RS38315 ENOG4108JPW Aminotransferase EJ357_RS38330 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) EJ357_RS38340 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EJ357_RS38355 ENOG4105BZU Histidine kinase EJ357_RS38360 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS38375 ENOG4105ECY inositol monophosphatase EJ357_RS38465 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS38470 ENOG4105BZU Histidine kinase EJ357_RS38490 ENOG41066UM arsR family transcriptional regulator EJ357_RS38500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ357_RS38570 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EJ357_RS38640 ENOG4105BZW Glycerate kinase EJ357_RS38650 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme EJ357_RS38655 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS38690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ357_RS38710 ENOG4106JDR secreted EJ357_RS38730 ENOG4108Q50 Histidine kinase EJ357_RS38740 ENOG4105E08 Glycoside hydrolase, family 9 EJ357_RS38765 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EJ357_RS38775 ENOG4107R9S Malate synthase EJ357_RS38805 ENOG4108JJB ABC transporter EJ357_RS38820 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) EJ357_RS38830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJ357_RS38835 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EJ357_RS38840 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJ357_RS38880 ENOG4105DIA mandelate racemase muconate lactonizing EJ357_RS38890 ENOG4105CV1 Transketolase (EC 2.2.1.1) EJ357_RS38895 ENOG4105DQE DNA ligase EJ357_RS38905 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth EJ357_RS38930 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) EJ357_RS38940 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) EJ357_RS38965 ENOG4105GCF PGAM EJ357_RS38970 ENOG4105C5H ABC transporter EJ357_RS38980 ENOG4105CH6 catalase EJ357_RS38985 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EJ357_RS39075 ENOG4105CFG Acts as a chaperone (By similarity) EJ357_RS39085 ENOG4105R3A Nitrate reductase EJ357_RS39090 ENOG4108IUE nitrate reductase beta subunit EJ357_RS39125 ENOG410842T Pterin carbinolamine dehydratase EJ357_RS39130 ENOG4108D32 Methyltransferase EJ357_RS39145 ENOG4105D29 Helix-turn-helix type 11 domain protein EJ357_RS39150 ENOG4105CX8 fg-gap repeat protein EJ357_RS39170 ENOG4105CYP glycoside hydrolase, family EJ357_RS39175 ENOG41065HY 1,4-beta-cellobiosidase EJ357_RS39205 ENOG4105CV8 reductase EJ357_RS39215 ENOG4105DUM transcriptional regulator, lysR family EJ357_RS39220 ENOG4105DHU Bile acid EJ357_RS39230 ENOG4108478 ec 3.2.1.18 EJ357_RS39235 ENOG4105CPQ Dehydrogenase EJ357_RS39240 ENOG4108VHT MarR family transcriptional regulator EJ357_RS39245 ENOG4105D3W isochorismatase EJ357_RS39250 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJ357_RS39265 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJ357_RS39270 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJ357_RS39280 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ357_RS39295 ENOG4105DKQ ROK family EJ357_RS39300 ENOG4105C2J ABC transporter EJ357_RS39305 ENOG4105CNN ABC, transporter EJ357_RS39310 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJ357_RS39355 ENOG4105F8V Hydrolase, tatD family EJ357_RS39380 ENOG4105FCD Major Facilitator EJ357_RS39400 ENOG4105CMV Succinyl-CoA synthetase subunit beta EJ357_RS39410 ENOG4105C26 Dehydrogenase EJ357_RS39445 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ357_RS39450 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ357_RS39470 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EJ357_RS39475 ENOG4108UYI beta-alanyl-CoA ammonia lyase EJ357_RS39480 ENOG4107UWP Major facilitator superfamily MFS_1 EJ357_RS39500 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ357_RS39520 ENOG4108S01 response regulator EJ357_RS39540 ENOG4105CJA serine threonine protein kinase EJ357_RS39555 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EJ357_RS39570 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EJ357_RS39600 ENOG4107TSG Extracellular solute-binding protein, family 5 EJ357_RS39605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS39620 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ357_RS39635 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJ357_RS39655 ENOG4107QJN gtp cyclohydrolase ii EJ357_RS39695 ENOG410905P Pyridoxamine 5-phosphate EJ357_RS39710 ENOG4107QQG Dehydrogenase EJ357_RS39715 ENOG4105CPK Glycosyl transferase (Group 1 EJ357_RS39720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EJ357_RS39725 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJ357_RS39740 ENOG4105CSH Transporter EJ357_RS39750 ENOG4107S9B Shikimate dehydrogenase EJ357_RS39755 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJ357_RS39780 ENOG4108J5G 6-phosphogluconate dehydrogenase EJ357_RS39785 ENOG4107QP8 phosphohexose isomerase EJ357_RS39800 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJ357_RS39830 ENOG4107R13 MMPL domain protein EJ357_RS39835 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS39840 ENOG4105BZU Histidine kinase EJ357_RS39910 ENOG41088CQ domain protein EJ357_RS39915 ENOG4105CNT hydrolase family 2 EJ357_RS39935 ENOG4108MGF sugar kinase EJ357_RS39945 ENOG4105F8D glycoside hydrolase family 4 EJ357_RS39960 ENOG4106UDK Cellulose-binding, family II EJ357_RS40020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ357_RS40025 ENOG4105CTU Proline racemase EJ357_RS40045 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJ357_RS40050 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EJ357_RS40055 ENOG4105CG3 alpha amylase, catalytic region EJ357_RS40070 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ357_RS40075 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJ357_RS40085 ENOG4107HP6 Transcriptional regulator EJ357_RS40100 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS40130 ENOG4108KQ5 Integrase catalytic subunit EJ357_RS40185 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EJ357_RS40190 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase EJ357_RS40195 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha EJ357_RS40220 ENOG41067TZ transcriptional regulator, MarR family EJ357_RS40240 ENOG4105DQE DNA ligase EJ357_RS40275 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS40285 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJ357_RS40300 ENOG4106V2I dimethylaminohydrolase EJ357_RS40305 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ357_RS40310 ENOG4105C5H ABC transporter EJ357_RS40315 ENOG4105KF0 sporulation and cell division protein, SsgA EJ357_RS40335 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EJ357_RS40365 ENOG4105EG6 Saccharopine dehydrogenase EJ357_RS40375 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EJ357_RS40385 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS40390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ357_RS40435 ENOG4105C94 Transporter EJ357_RS40445 ENOG4105C5H ABC transporter EJ357_RS40450 ENOG4105FQP Beta-lactamase EJ357_RS40460 ENOG4105BZM domain protein EJ357_RS40480 ENOG4105E39 Enoyl-CoA hydratase EJ357_RS40495 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EJ357_RS40520 ENOG4108MDK Dehydrogenase EJ357_RS40540 ENOG4105EY8 ABC transporter EJ357_RS40545 ENOG4105FBD synthase EJ357_RS40555 ENOG4107S11 squalene-associated FAD-dependent desaturase EJ357_RS40565 ENOG4105EWU Squalene--hopene cyclase EJ357_RS40580 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EJ357_RS40625 ENOG4105CX8 fg-gap repeat protein EJ357_RS40635 ENOG41090WU lipolytic protein G-D-S-L family EJ357_RS40685 ENOG4105CPQ Dehydrogenase EJ357_RS40690 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EJ357_RS40695 ENOG4106NZI LysR family Transcriptional regulator EJ357_RS40725 ENOG4107TPY serine threonine protein kinase EJ357_RS40735 ENOG4105D9P serine threonine protein kinase EJ357_RS40760 ENOG4105BZ1 (ABC) transporter EJ357_RS40780 ENOG4105J7D transcriptional regulator EJ357_RS40795 ENOG4105C5F glutamine synthetase EJ357_RS40820 ENOG4108IMY Transcriptional regulator EJ357_RS40825 ENOG4105H1N peptidase, M24 EJ357_RS40830 ENOG4107RUY (E1 component), alpha subunit EJ357_RS40840 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS40875 ENOG4105E5G Alpha beta hydrolase fold EJ357_RS40880 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS40950 ENOG4105CPP Dehydrogenase, E1 component EJ357_RS40955 ENOG4108IV0 ABC, transporter EJ357_RS40960 ENOG4105C0Z ABC transporter EJ357_RS40975 ENOG4105C32 Amino acid ABC transporter (Permease) EJ357_RS41025 ENOG4107VIJ nudix hydrolase EJ357_RS41030 ENOG4105KBX Transcriptional regulator, TetR family EJ357_RS41035 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) EJ357_RS41045 ENOG4105CG5 Glycosyl transferase (Group 1 EJ357_RS41060 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJ357_RS41070 ENOG4105E2K Glycosyl transferase (Group 1 EJ357_RS41080 ENOG4105BZP glycoside hydrolase 15-related EJ357_RS41095 ENOG4105CMR udp-glucose 4-epimerase EJ357_RS41110 ENOG4105FDP GntR family transcriptional regulator EJ357_RS41115 ENOG4105C26 Dehydrogenase EJ357_RS41120 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EJ357_RS41125 ENOG4105DH8 myo-inositol catabolism EJ357_RS41135 ENOG4105EDK PfkB domain protein EJ357_RS41145 ENOG4105CNN ABC, transporter EJ357_RS41150 ENOG4105C2J ABC transporter EJ357_RS41160 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EJ357_RS41175 ENOG4105CHR reductase EJ357_RS41200 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS41210 ENOG4108QBF Transcriptional regulator EJ357_RS41220 ENOG4105JSC dimethylmenaquinone methyltransferase EJ357_RS41255 ENOG4105CHR reductase EJ357_RS41275 ENOG4107QJE Chromosome Partitioning Protein EJ357_RS41345 ENOG4107R16 Multicopper oxidase EJ357_RS41385 ENOG4108K8U Glycerol operon regulatory protein EJ357_RS41390 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EJ357_RS41395 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJ357_RS41400 ENOG4105D7T ABC transporter EJ357_RS41420 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EJ357_RS41430 ENOG4105EAB amino acid AbC transporter EJ357_RS41435 ENOG4105E5Q amino acid AbC transporter EJ357_RS41440 ENOG4105CDA abc transporter atp-binding protein EJ357_RS41445 ENOG4105EAB amino acid AbC transporter EJ357_RS41450 ENOG4107RIQ Sulfate adenylate transferase EJ357_RS41460 ENOG4107RSM transcriptional regulator EJ357_RS41465 ENOG4105FBW Monooxygenase EJ357_RS41480 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EJ357_RS41485 ENOG4107T8P acyl-Coa dehydrogenase EJ357_RS41545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ357_RS41565 ENOG4108ZGX Histidine kinase EJ357_RS41575 ENOG4105CE4 GlcNAc 6-P deacetylase EJ357_RS41605 ENOG4105KMT branched-chain amino acid EJ357_RS41625 ENOG4108TGC Acyltransferase EJ357_RS41640 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EJ357_RS41665 ENOG4105C9B Cysteine desulfurase EJ357_RS41670 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EJ357_RS41690 ENOG4105DCG PHP domain protein EJ357_RS41720 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJ357_RS41725 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJ357_RS41745 ENOG410681U heavy metal transport detoxification protein EJ357_RS41755 ENOG4105TVJ transport system, permease EJ357_RS41760 ENOG4105DQ5 transport system permease protein EJ357_RS41765 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EJ357_RS41775 ENOG4105E8G Major facilitator Superfamily EJ357_RS41785 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EJ357_RS41805 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS41830 ENOG4105WQI isochorismatase EJ357_RS41835 ENOG4105BZP glycoside hydrolase 15-related EJ357_RS41840 ENOG4105E98 transcriptional regulator DeoR family EJ357_RS41845 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJ357_RS41860 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) EJ357_RS41870 ENOG4105DKQ ROK family EJ357_RS41880 ENOG4108YZG isomerase EJ357_RS41910 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS41915 ENOG4107R34 abc transporter permease protein EJ357_RS41940 ENOG4105MVE transcriptional regulator EJ357_RS41950 ENOG4106F1P AAA ATPase, central domain protein EJ357_RS41975 ENOG4107R8N Glycosyl transferase, family 2 EJ357_RS42000 ENOG41062IR nudix hydrolase EJ357_RS42020 ENOG4108KQ5 Integrase catalytic subunit EJ357_RS42050 ENOG4106F1P AAA ATPase, central domain protein EJ357_RS42055 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS42060 ENOG4105EC2 ftsk spoIIIe EJ357_RS42120 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS42155 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS42160 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS42170 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EJ357_RS42175 ENOG4105DIH basic membrane EJ357_RS42180 ENOG4108JQ9 ABC transporter EJ357_RS42190 ENOG4108ZV0 ABC transporter, permease EJ357_RS42205 ENOG4105EX0 alpha-galactosidase EJ357_RS42235 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJ357_RS42290 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS42295 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJ357_RS42320 ENOG4108JDX DNA polymerase iii, epsilon subunit EJ357_RS42325 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS42330 ENOG4105BZU Histidine kinase EJ357_RS42360 ENOG4105HS2 Arsenate reductase EJ357_RS42365 ENOG4108JCI Transcriptional regulator EJ357_RS42390 ENOG41062IR nudix hydrolase EJ357_RS42415 ENOG4105E7U AraC family transcriptional regulator EJ357_RS42430 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS42435 ENOG4108JIK carboxylase EJ357_RS42440 ENOG4107TXC Transcriptional regulator EJ357_RS42475 ENOG4106A3M Cytochrome p-450 EJ357_RS42495 ENOG4105D74 hydrolase EJ357_RS42500 ENOG4105CHU acetyl-coa acetyltransferase EJ357_RS42510 ENOG4108W9H Tetr family transcriptional regulator EJ357_RS42545 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ357_RS42565 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS42575 ENOG4105DND Transcriptional regulator EJ357_RS42585 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJ357_RS42590 ENOG4107U9T Pfam:Ribonuclease_BN EJ357_RS42620 ENOG4105I6B RNA polymerase EJ357_RS42650 ENOG4105C2J ABC transporter EJ357_RS42655 ENOG4105CNN ABC, transporter EJ357_RS42665 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJ357_RS42680 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJ357_RS42700 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJ357_RS42750 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EJ357_RS42765 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein EJ357_RS42770 ENOG4107S9F NmrA family EJ357_RS42780 ENOG4105KVH Transcriptional regulator EJ357_RS42805 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJ357_RS42810 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJ357_RS42825 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS42840 ENOG4105C0W non-ribosomal peptide synthetase EJ357_RS42845 ENOG4105JAB phenazine biosynthesis protein, phzf family EJ357_RS42875 ENOG4105TVJ transport system, permease EJ357_RS42880 ENOG4105DQ5 transport system permease protein EJ357_RS42885 ENOG4108MES Periplasmic binding protein EJ357_RS42900 ENOG4106IPI cyclase, family EJ357_RS42915 ENOG4108KXM LysR family Transcriptional regulator EJ357_RS42920 ENOG4107MM9 BNR Asp-box repeat-containing protein EJ357_RS42925 ENOG4105EC2 ftsk spoIIIe EJ357_RS43005 ENOG4108E1C hydrolase EJ357_RS43015 ENOG4105EC3 peptidase S51, dipeptidase E EJ357_RS43020 ENOG4108KC1 acyl-Coa dehydrogenase EJ357_RS43045 ENOG4105ETE Transcriptional regulator (LacI family EJ357_RS43055 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJ357_RS43085 ENOG41083YR Protein CrcB homolog EJ357_RS43090 ENOG4105KJJ Uncharacterized ACR, COG1993 EJ357_RS43100 ENOG41073TP transcriptional regulator EJ357_RS43115 ENOG4108IJ0 Aspartate ammonia-lyase EJ357_RS43120 ENOG4105CSV Glutaminase EJ357_RS43125 ENOG41090CE integral membrane protein EJ357_RS43135 ENOG4105DZ1 carboxypeptidase EJ357_RS43160 ENOG4105U3E Transcriptional regulator EJ357_RS43165 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) EJ357_RS43170 ENOG4105FDP GntR family transcriptional regulator EJ357_RS43185 ENOG4105I82 acetyl xylan esterase EJ357_RS43190 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ357_RS43210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJ357_RS43235 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJ357_RS43240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ357_RS43255 ENOG4105CYP glycoside hydrolase, family EJ357_RS43265 ENOG4105CHR reductase EJ357_RS43280 ENOG4108UTZ Dihydroxyacetone kinase EJ357_RS43285 ENOG4105CMT Dihydroxyacetone kinase EJ357_RS43315 ENOG4108IEG Formate dehydrogenase Alpha subunit EJ357_RS43335 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJ357_RS43355 ENOG4106943 Heat shock protein EJ357_RS43385 ENOG4105E2A Dehydrogenase EJ357_RS43395 ENOG4108JYK Dehydrogenase EJ357_RS43400 ENOG4105CPP Dehydrogenase, E1 component EJ357_RS43405 ENOG4105C7S Dehydrogenase EJ357_RS43430 ENOG4107WUB V-type ATPase 116 kDa subunit EJ357_RS43450 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) EJ357_RS43455 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) EJ357_RS43470 ENOG4107VEG TrkA-N domain protein EJ357_RS43475 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJ357_RS43485 ENOG4107R16 Multicopper oxidase EJ357_RS43510 ENOG4105VPX protein, conserved in bacteria EJ357_RS43520 ENOG4105EIE fructose-bisphosphate aldolase EJ357_RS43535 ENOG4105CTQ phosphohexokinase EJ357_RS43540 ENOG4105CJW magnesium transporter EJ357_RS43560 ENOG4105E2A Dehydrogenase EJ357_RS43585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJ357_RS43605 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EJ357_RS43610 ENOG4105W8H transhydrogenase (subunit alpha EJ357_RS43615 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EJ357_RS43630 ENOG4105BZ8 glutamate synthase EJ357_RS43635 ENOG4105DDK oxidoreductase, beta subunit EJ357_RS43640 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EJ357_RS43670 ENOG4108YV4 Universal stress protein EJ357_RS43715 ENOG4105CJ1 ABC, transporter EJ357_RS43800 ENOG4105CD5 CoA-binding domain protein EJ357_RS43805 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJ357_RS43825 ENOG4105CQS hydrogenase expression formation protein HypD EJ357_RS43830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJ357_RS43845 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EJ357_RS43860 ENOG41082MF Hydrogenase assembly chaperone hypC hupF EJ357_RS43885 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJ357_RS43895 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ357_RS43910 ENOG4105DEN Luciferase family EJ357_RS43915 ENOG4105DEN Luciferase family EJ357_RS43935 ENOG4105DWV Homoserine O-trans-acetylase EJ357_RS43960 ENOG4105DFH Transport of potassium into the cell (By similarity) EJ357_RS43970 ENOG4107AQZ Membrane EJ357_RS43975 ENOG4105EQ2 LysR family Transcriptional regulator EJ357_RS43995 ENOG4105CSR polyphosphate kinase 2 EJ357_RS44015 ENOG4105X7H acyl-CoA dehydrogenase EJ357_RS44035 ENOG4107S1E Beta-lactamase EJ357_RS44060 ENOG4105JZI cytochrome P450 EJ357_RS44070 ENOG4105CEY Amp-dependent synthetase and ligase EJ357_RS44115 ENOG4105E9F Enoyl-CoA hydratase EJ357_RS44175 ENOG4105KF0 sporulation and cell division protein, SsgA EJ357_RS44260 ENOG4105CHP RNA polymerase EJ357_RS44265 ENOG4108IV0 ABC, transporter EJ357_RS44270 ENOG4105C0Z ABC transporter EJ357_RS44280 ENOG4105C32 Amino acid ABC transporter (Permease) EJ357_RS44300 ENOG4105FDP GntR family transcriptional regulator EJ357_RS44325 ENOG4108IYU L-aspartate oxidase EJ357_RS44335 ENOG4107S5I aldo keto reductase EJ357_RS44340 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) EJ357_RS44355 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase EJ357_RS44360 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJ357_RS44370 ENOG4107RSM transcriptional regulator EJ357_RS44375 ENOG4105CPC Aldo Keto reductase EJ357_RS44400 ENOG4105D9P serine threonine protein kinase EJ357_RS44420 ENOG4105WBV Transcriptional regulator EJ357_RS44425 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJ357_RS44430 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJ357_RS44435 ENOG4105CIR epoxide hydrolase EJ357_RS44450 ENOG4108PA7 Methyltransferase EJ357_RS44460 ENOG4105ESN nucleotide-binding protein EJ357_RS44475 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJ357_RS44500 ENOG4105CPC Aldo Keto reductase EJ357_RS44520 ENOG4107QPV Serine Threonine protein kinase EJ357_RS44545 ENOG4105K4I Scp-like extracellular EJ357_RS44555 ENOG4105E2R ROK family EJ357_RS44560 ENOG4105EX0 alpha-galactosidase EJ357_RS44575 ENOG4107SM8 Adenylate Guanylate cyclase EJ357_RS44585 ENOG4105CUX Signal transduction histidine kinase EJ357_RS44695 ENOG4105C5X domain protein EJ357_RS44740 ENOG4105BZU Histidine kinase EJ357_RS44760 ENOG4105E8G Major facilitator Superfamily EJ357_RS44780 ENOG4105CEP NADH dehydrogenase EJ357_RS44800 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EJ357_RS44815 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) EJ357_RS44865 ENOG4107QRI Phosphoketolase EJ357_RS44885 ENOG4105WN5 stage II sporulation protein EJ357_RS44930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EJ357_RS44935 ENOG4105F27 Major Facilitator EJ357_RS44955 ENOG4105DQE DNA ligase EJ357_RS44960 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS44965 ENOG4105BZU Histidine kinase EJ357_RS44975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS45000 ENOG4105EU0 Major facilitator Superfamily EJ357_RS45005 ENOG4105R1U AraC Family Transcriptional Regulator EJ357_RS45030 ENOG4105DQE DNA ligase EJ357_RS45045 ENOG4108HKT sucrose-6-phosphate hydrolase EJ357_RS45050 ENOG4105DRS transport system, permease EJ357_RS45055 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJ357_RS45065 ENOG4108HKT sucrose-6-phosphate hydrolase EJ357_RS45085 ENOG4105EYF MMPL domain protein EJ357_RS45090 ENOG4105BZU Histidine kinase EJ357_RS45095 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS45100 ENOG4105EBM Alpha Beta Hydrolase Fold protein EJ357_RS45125 ENOG4105BZU Histidine kinase EJ357_RS45130 ENOG41066UZ arginase EC 3.5.3.1 EJ357_RS45160 ENOG4105F27 Major Facilitator EJ357_RS45180 ENOG4107RTD sua5 ycio yrdc ywlc family protein EJ357_RS45230 ENOG4107RCI amp-dependent synthetase and ligase EJ357_RS45240 ENOG4107P5I polyketide synthase EJ357_RS45250 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJ357_RS45255 ENOG41082YX Transcriptional regulator, arsr family EJ357_RS45295 ENOG4107R3A FAD linked oxidase domain protein EJ357_RS45300 ENOG4107TE5 Lipid kinase EJ357_RS45310 ENOG41082AN stage II sporulation protein EJ357_RS45340 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EJ357_RS45345 ENOG4105DE4 1-phosphofructokinase EJ357_RS45355 ENOG41062D9 Histidine kinase EJ357_RS45360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ357_RS45365 ENOG4105CSH Transporter EJ357_RS45385 ENOG4105XPP Protein of unknown function (DUF1275) EJ357_RS45410 ENOG4105C9B Cysteine desulfurase EJ357_RS45415 ENOG4105ESN nucleotide-binding protein EJ357_RS45415 ENOG4105ESN nucleotide-binding protein EJ357_RS45440 ENOG4105C84 Histidine ammonia-lyase EJ357_RS45455 ENOG4105E90 ABC transporter EJ357_RS45470 ENOG4108N5B 2-phosphosulfolactate phosphatase EJ357_RS45480 ENOG4105EXW epimerase dehydratase EJ357_RS45510 ENOG4105EGE secreted protein EJ357_RS45515 ENOG4106UDK Cellulose-binding, family II EJ357_RS45535 ENOG4105T16 Transcriptional regulator (AraC family) EJ357_RS45550 ENOG4108PC0 lipolytic protein G-D-S-L family EJ357_RS45625 ENOG4105DSG hydrolase family 43 EJ357_RS45640 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJ357_RS45650 ENOG4105CJQ hydrolase, family 31 EJ357_RS45665 ENOG4108JPW Aminotransferase EJ357_RS45670 ENOG4105CQB FAD linked oxidase domain protein EJ357_RS45685 ENOG4108FUF Transcriptional regulator, IclR family EJ357_RS45690 ENOG4107HP6 Transcriptional regulator EJ357_RS45710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ357_RS45725 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ357_RS45730 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase EJ357_RS45740 ENOG4107SET aldo keto reductase EJ357_RS45755 ENOG4108IJ0 Aspartate ammonia-lyase EJ357_RS45780 ENOG4105CJP fad dependent oxidoreductase EJ357_RS45790 ENOG4105KME endoribonuclease L-psp EJ357_RS45835 ENOG4105KME endoribonuclease L-psp EJ357_RS45845 ENOG4105CHR reductase EJ357_RS45895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ357_RS45905 ENOG4108I69 Glycosyl transferases group 1 EJ357_RS45925 ENOG4105C2J ABC transporter EJ357_RS45930 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EJ357_RS45935 ENOG4105DIA mandelate racemase muconate lactonizing EJ357_RS45950 ENOG4105CPQ Dehydrogenase EJ357_RS45955 ENOG4105CHR reductase EJ357_RS45960 ENOG4108UHU Aldolase EJ357_RS45975 ENOG4107U9B transcriptional regulator EJ357_RS45990 ENOG4105DK0 Indole-3-glycerol phosphate synthase EJ357_RS46020 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJ357_RS46070 ENOG4105H3G oxidoreductase EJ357_RS46075 ENOG4105CHR reductase EJ357_RS46080 ENOG4105C26 Dehydrogenase EJ357_RS46085 ENOG4108ZX5 transcriptional regulator EJ357_RS46090 ENOG4105BZU Histidine kinase EJ357_RS46095 ENOG4105WH1 Two component transcriptional regulator luxr family EJ357_RS46115 ENOG4107S5I aldo keto reductase EJ357_RS46145 ENOG4105C26 Dehydrogenase EJ357_RS46185 ENOG4108UKI Enoyl-CoA hydratase EJ357_RS46190 ENOG4105C1G acyl-Coa dehydrogenase EJ357_RS46210 ENOG4107QN1 sodium solute EJ357_RS46330 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJ357_RS46335 ENOG4106F60 Histidine kinase EJ357_RS46340 ENOG4105F44 Two component transcriptional regulator, winged helix family EJ357_RS46410 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EJ357_RS46415 ENOG4105KVH Transcriptional regulator EJ357_RS46490 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EJ357_RS46535 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJ357_RS46560 ENOG4105CNN ABC, transporter EJ357_RS46570 ENOG4105C0Z ABC transporter EJ357_RS46575 ENOG4108IV0 ABC, transporter EJ357_RS46615 ENOG41080XP Cbs domain EJ357_RS46660 ENOG4105ZXU NLP P60 protein EJ357_RS46695 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ357_RS46750 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr EJ357_RS46815 ENOG4108JNI Alpha beta hydrolase EJ357_RS46930 ENOG4105VMP Transcriptional regulator EJ357_RS46935 ENOG41068WN EJ357_RS46940 ENOG41067TZ transcriptional regulator, MarR family EJ357_RS46945 ENOG4105CHR reductase EJ357_RS46955 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJ357_RS46995 ENOG4107SVN transposase EJ357_RS47020 ENOG4105C7F AcnD-accessory protein PrpF EJ357_RS47090 ENOG4105DTD Dehydrogenase EJ357_RS47095 ENOG4107RSM transcriptional regulator EJ357_RS47105 ENOG4105E1F short-chain dehydrogenase reductase EJ357_RS47110 ENOG4105D4K integrase catalytic EJ357_RS47240 ENOG4108Z6Z Transcriptional regulator EJ357_RS47255 ENOG4105EMU Dehydrogenase EJ357_RS47270 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJ357_RS47315 ENOG4105E2Y ABC, transporter EJ357_RS47335 ENOG4108Z4X TRANSCRIPTIONal EJ357_RS47340 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ357_RS47455 ENOG4105CHR reductase EJ357_RS47500 ENOG4105I1F Resistance protein EJ357_RS47525 ENOG4105C0W non-ribosomal peptide synthetase EJ357_RS47665 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ357_RS47685 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJ357_RS47695 ENOG4105ECQ AraC Family Transcriptional Regulator EJ357_RS47715 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EJ357_RS47840 ENOG4105EYH Exonuclease EJ357_RS47845 ENOG4107RH8 nuclease SbcCD subunit D