locus-tag	class	description
S1361_RS00070	COG0419	ATPase involved in DNA repair
S1361_RS00075	COG0420	3'-5' exonuclease activity
S1361_RS00160	COG2816	NAD+ diphosphatase activity
S1361_RS00225	COG1864	DNA RNA non-specific endonuclease
S1361_RS00225	COG3591	Belongs to the peptidase S1B family
S1361_RS00265	COG3209	COG3209 Rhs family protein
S1361_RS00265	COG4104	PAAR repeat-containing protein
S1361_RS00505	COG5183	chlorophyll binding
S1361_RS00505	COG2133	pyrroloquinoline quinone binding
S1361_RS00525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS00690	COG1278	Cold shock
S1361_RS00715	COG1278	Cold shock
S1361_RS00720	COG2267	carboxylic ester hydrolase activity
S1361_RS00755	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS00855	COG2223	nitrite transmembrane transporter activity
S1361_RS00905	COG1917	Cupin 2, conserved barrel domain protein
S1361_RS00905	COG2207	Transcriptional regulator
S1361_RS00950	COG1476	TRANSCRIPTIONal
S1361_RS00955	COG0604	alcohol dehydrogenase
S1361_RS00970	COG4977	sequence-specific DNA binding
S1361_RS01045	COG1335	isochorismatase
S1361_RS01050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S1361_RS01080	COG0546	phosphoglycolate phosphatase activity
S1361_RS01095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S1361_RS01135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S1361_RS01140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S1361_RS01145	COG0604	alcohol dehydrogenase
S1361_RS01145	COG3321	synthase
S1361_RS01145	COG3321	synthase
S1361_RS01145	COG0604	alcohol dehydrogenase
S1361_RS01150	COG3321	synthase
S1361_RS01150	COG0604	alcohol dehydrogenase
S1361_RS01215	COG0789	Transcriptional regulator
S1361_RS01230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S1361_RS01270	COG2197	response regulator
S1361_RS01275	COG4585	Histidine kinase
S1361_RS01285	COG0596	Alpha beta hydrolase
S1361_RS01300	COG2084	Dehydrogenase
S1361_RS01360	COG1309	transcriptional regulator
S1361_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS01375	COG0183	Belongs to the thiolase family
S1361_RS01380	COG0596	Alpha beta hydrolase
S1361_RS01390	COG1335	isochorismatase
S1361_RS01395	COG1802	Transcriptional regulator
S1361_RS01400	COG0277	FAD linked oxidase domain protein
S1361_RS01440	COG2814	Major facilitator Superfamily
S1361_RS01510	COG0477	Major facilitator Superfamily
S1361_RS01530	COG2318	DinB family
S1361_RS01555	COG1309	transcriptional regulator
S1361_RS01560	COG2267	carboxylic ester hydrolase activity
S1361_RS01580	COG2508	Transcriptional regulator
S1361_RS01620	COG2249	NAD(P)H dehydrogenase (quinone) activity
S1361_RS01630	COG0596	Alpha beta hydrolase
S1361_RS01635	COG2318	DinB family
S1361_RS01645	COG1902	pentaerythritol trinitrate reductase activity
S1361_RS01665	COG1309	transcriptional regulator
S1361_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS01675	COG0667	Aldo Keto reductase
S1361_RS01695	COG0583	DNA-binding transcription factor activity
S1361_RS01725	COG1309	transcriptional regulator
S1361_RS01770	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS01770	COG2319	Wd-40 repeat
S1361_RS01790	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S1361_RS01870	COG4977	sequence-specific DNA binding
S1361_RS01905	COG2207	Transcriptional regulator
S1361_RS01905	COG3708	Transcriptional regulator
S1361_RS01925	COG1595	DNA-templated transcription, initiation
S1361_RS01945	COG0745	RESPONSE REGULATOR receiver
S1361_RS01950	COG2205	protein histidine kinase activity
S1361_RS01960	COG0583	DNA-binding transcription factor activity
S1361_RS01965	COG5640	endopeptidase activity
S1361_RS01985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S1361_RS01995	COG0477	Major facilitator Superfamily
S1361_RS02005	COG0302	gtp cyclohydrolase
S1361_RS02025	COG0300	oxidoreductase activity
S1361_RS02040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S1361_RS02050	COG3608	succinylglutamate desuccinylase aspartoacylase
S1361_RS02050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S1361_RS02055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1361_RS02060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S1361_RS02065	COG2080	2 iron, 2 sulfur cluster binding
S1361_RS02080	COG3903	Transcriptional regulator
S1361_RS02080	COG3629	intracellular signal transduction
S1361_RS02100	COG0583	DNA-binding transcription factor activity
S1361_RS02115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S1361_RS02155	COG5297	Belongs to the glycosyl hydrolase family 6
S1361_RS02180	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS02180	COG2319	Wd-40 repeat
S1361_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS02220	COG3896	Chloramphenicol phosphotransferase-like protein
S1361_RS02240	COG2197	response regulator
S1361_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS02250	COG1295	ribonuclease BN
S1361_RS02350	COG0375	protein maturation
S1361_RS02365	COG0298	carbon dioxide binding
S1361_RS02370	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
S1361_RS02375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S1361_RS02380	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S1361_RS02385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S1361_RS02385	COG1024	Enoyl-CoA hydratase
S1361_RS02430	COG0640	Transcriptional regulator
S1361_RS02520	COG0477	Major facilitator Superfamily
S1361_RS02525	COG0667	Aldo Keto reductase
S1361_RS02540	COG0586	Pfam SNARE associated Golgi protein
S1361_RS02565	COG0784	Response regulator, receiver
S1361_RS02565	COG2205	protein histidine kinase activity
S1361_RS02565	COG5002	protein histidine kinase activity
S1361_RS02570	COG0437	4 iron, 4 sulfur cluster binding
S1361_RS02580	COG3383	formate dehydrogenase (NAD+) activity
S1361_RS02580	COG0243	molybdopterin cofactor binding
S1361_RS02585	COG3383	formate dehydrogenase (NAD+) activity
S1361_RS02585	COG0243	molybdopterin cofactor binding
S1361_RS02590	COG0709	Synthesizes selenophosphate from selenide and ATP
S1361_RS02635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S1361_RS02660	COG2267	carboxylic ester hydrolase activity
S1361_RS02675	COG3291	Pkd domain containing protein
S1361_RS02680	COG0583	DNA-binding transcription factor activity
S1361_RS02690	COG1733	regulation of RNA biosynthetic process
S1361_RS02715	COG4257	antibiotic catabolic process
S1361_RS02740	COG0673	inositol 2-dehydrogenase activity
S1361_RS02780	COG2124	cytochrome p450
S1361_RS02785	COG0009	L-threonylcarbamoyladenylate synthase
S1361_RS02830	COG1175	transmembrane transport
S1361_RS02835	COG0395	ABC-type sugar transport system, permease component
S1361_RS02840	COG1621	beta-fructofuranosidase activity
S1361_RS02845	COG1609	Transcriptional regulator
S1361_RS02890	COG1414	Transcriptional regulator
S1361_RS02895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S1361_RS02905	COG0181	hydroxymethylbilane synthase activity
S1361_RS02950	COG0366	Alpha amylase catalytic
S1361_RS02960	COG3281	Trehalose synthase
S1361_RS02965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S1361_RS02970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S1361_RS02990	COG1252	NADH dehydrogenase
S1361_RS03050	COG5002	protein histidine kinase activity
S1361_RS03090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1361_RS03130	COG1672	PFAM Archaeal ATPase
S1361_RS03130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S1361_RS03155	COG2340	Cysteine-rich secretory protein family
S1361_RS03170	COG0142	geranyltranstransferase activity
S1361_RS03180	COG0515	serine threonine protein kinase
S1361_RS03180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S1361_RS03185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS03195	COG3647	Membrane
S1361_RS03260	COG0328	RNA-DNA hybrid ribonuclease activity
S1361_RS03280	COG1396	sequence-specific DNA binding
S1361_RS03285	COG1191	sigma factor activity
S1361_RS03320	COG0667	Aldo Keto reductase
S1361_RS03325	COG0583	DNA-binding transcription factor activity
S1361_RS03335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S1361_RS03340	COG0346	lactoylglutathione lyase activity
S1361_RS03355	COG0667	Aldo Keto reductase
S1361_RS03365	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS03370	COG4941	Belongs to the sigma-70 factor family
S1361_RS03405	COG0531	amino acid
S1361_RS03410	COG1940	carbohydrate kinase activity
S1361_RS03415	COG3250	beta-galactosidase activity
S1361_RS03460	COG2267	carboxylic ester hydrolase activity
S1361_RS03470	COG0673	inositol 2-dehydrogenase activity
S1361_RS03490	COG0510	thiamine kinase activity
S1361_RS03540	COG1024	Enoyl-CoA hydratase
S1361_RS03580	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS03585	COG2366	antibiotic biosynthetic process
S1361_RS03595	COG2070	2-Nitropropane dioxygenase
S1361_RS03620	COG0516	GMP reductase activity
S1361_RS03620	COG0517	IMP dehydrogenase activity
S1361_RS03640	COG1063	alcohol dehydrogenase
S1361_RS03660	COG2239	Acts as a magnesium transporter
S1361_RS03670	COG1063	alcohol dehydrogenase
S1361_RS03690	COG1960	acyl-CoA dehydrogenase activity
S1361_RS03740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S1361_RS03740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S1361_RS03745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
S1361_RS03750	COG0297	glycogen (starch) synthase activity
S1361_RS03755	COG0438	transferase activity, transferring glycosyl groups
S1361_RS03765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
S1361_RS03775	COG2192	nodulation
S1361_RS03780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S1361_RS03805	COG2376	Dihydroxyacetone kinase
S1361_RS03810	COG1461	Dihydroxyacetone kinase
S1361_RS03840	COG0446	pyridine nucleotide-disulphide oxidoreductase
S1361_RS03840	COG1902	pentaerythritol trinitrate reductase activity
S1361_RS03865	COG2890	protein-(glutamine-N5) methyltransferase activity
S1361_RS03885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S1361_RS03905	COG3458	cephalosporin-C deacetylase activity
S1361_RS03910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S1361_RS03915	COG2188	Transcriptional regulator
S1361_RS03920	COG2226	methyltransferase
S1361_RS03975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S1361_RS03995	COG2066	Belongs to the glutaminase family
S1361_RS04010	COG1113	amino acid transport
S1361_RS04015	COG2186	Transcriptional regulator
S1361_RS04020	COG1968	undecaprenyl-diphosphatase activity
S1361_RS04025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S1361_RS04030	COG1993	acr, cog1993
S1361_RS04035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S1361_RS04050	COG2197	response regulator
S1361_RS04055	COG4585	Histidine kinase
S1361_RS04060	COG1136	(ABC) transporter
S1361_RS04070	COG0346	lactoylglutathione lyase activity
S1361_RS04080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S1361_RS04115	COG2223	nitrite transmembrane transporter activity
S1361_RS04120	COG2207	Transcriptional regulator
S1361_RS04125	COG2340	Cysteine-rich secretory protein family
S1361_RS04145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S1361_RS04210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S1361_RS04215	COG1881	PFAM PEBP family protein
S1361_RS04275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S1361_RS04295	COG2124	cytochrome p450
S1361_RS04315	COG0072	phenylalanine-tRNA ligase activity
S1361_RS04315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S1361_RS04350	COG0243	molybdopterin cofactor binding
S1361_RS04355	COG2267	carboxylic ester hydrolase activity
S1361_RS04375	COG4213	ABC transporter substrate-binding protein
S1361_RS04385	COG4213	ABC transporter substrate-binding protein
S1361_RS04390	COG1129	ABC transporter
S1361_RS04395	COG4214	carbohydrate transport
S1361_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS04425	COG2130	NADP-dependent
S1361_RS04435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS04445	COG3835	regulator
S1361_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS04505	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS04505	COG2172	sigma factor antagonist activity
S1361_RS04505	COG2208	phosphoserine phosphatase activity
S1361_RS04510	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS04510	COG2319	Wd-40 repeat
S1361_RS04530	COG1309	transcriptional regulator
S1361_RS04570	COG3629	intracellular signal transduction
S1361_RS04570	COG3903	Transcriptional regulator
S1361_RS04590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S1361_RS04600	COG0714	Associated with various cellular activities
S1361_RS04615	COG0151	Belongs to the GarS family
S1361_RS04635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S1361_RS04655	COG0367	asparagine synthase
S1361_RS04690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S1361_RS04705	COG4310	Domain of unknown function (DUF2172)
S1361_RS04715	COG1215	transferase activity, transferring glycosyl groups
S1361_RS04725	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S1361_RS04730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S1361_RS04745	COG1597	lipid kinase activity
S1361_RS04780	COG2909	trisaccharide binding
S1361_RS04785	COG1376	ErfK ybiS ycfS ynhG family protein
S1361_RS04800	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS04810	COG0251	oxidation-reduction process
S1361_RS04815	COG2207	Transcriptional regulator
S1361_RS04840	COG2409	Drug exporters of the RND superfamily
S1361_RS04845	COG1309	transcriptional regulator
S1361_RS04875	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS04875	COG2208	phosphoserine phosphatase activity
S1361_RS04875	COG2172	sigma factor antagonist activity
S1361_RS04905	COG0577	efflux transmembrane transporter activity
S1361_RS04910	COG1136	(ABC) transporter
S1361_RS04915	COG4585	Histidine kinase
S1361_RS04920	COG2197	response regulator
S1361_RS04925	COG0604	alcohol dehydrogenase
S1361_RS04935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S1361_RS04950	COG1250	3-hydroxyacyl-CoA dehydrogenase
S1361_RS04955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS04965	COG1960	acyl-CoA dehydrogenase activity
S1361_RS05005	COG1819	glycosyl
S1361_RS05010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S1361_RS05030	COG0475	glutathione-regulated potassium exporter activity
S1361_RS05040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S1361_RS05140	COG0604	alcohol dehydrogenase
S1361_RS05140	COG3321	synthase
S1361_RS05215	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S1361_RS05230	COG0367	asparagine synthase
S1361_RS05235	COG0477	Major facilitator Superfamily
S1361_RS05245	COG1120	ATPase activity
S1361_RS05250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S1361_RS05275	COG3977	Valine--pyruvate aminotransferase
S1361_RS05280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS05290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS05305	COG3251	PFAM MbtH domain protein
S1361_RS05325	COG2124	cytochrome p450
S1361_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS05365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S1361_RS05370	COG1215	transferase activity, transferring glycosyl groups
S1361_RS05405	COG1349	DNA-binding transcription factor activity
S1361_RS05415	COG1024	Enoyl-CoA hydratase
S1361_RS05420	COG2124	cytochrome p450
S1361_RS05510	COG1940	carbohydrate kinase activity
S1361_RS05515	COG2813	Specifically methylates the guanine in position
S1361_RS05525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S1361_RS05530	COG1349	DNA-binding transcription factor activity
S1361_RS05545	COG3579	cysteine-type endopeptidase activity
S1361_RS05570	COG2197	response regulator
S1361_RS05575	COG4585	Histidine kinase
S1361_RS05590	COG0445	tRNA wobble uridine modification
S1361_RS05600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1361_RS05605	COG1660	Displays ATPase and GTPase activities
S1361_RS05615	COG3345	alpha-galactosidase
S1361_RS05635	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S1361_RS05655	COG0204	Acyl-transferase
S1361_RS05700	COG0584	glycerophosphoryl diester phosphodiesterase
S1361_RS05740	COG0671	phosphoesterase, PA-phosphatase related
S1361_RS05765	COG0640	Transcriptional regulator
S1361_RS05770	COG1902	pentaerythritol trinitrate reductase activity
S1361_RS05775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S1361_RS05790	COG3135	benzoate transporter
S1361_RS05805	COG1960	acyl-CoA dehydrogenase activity
S1361_RS05825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S1361_RS05830	COG2971	BadF BadG BcrA BcrD
S1361_RS05840	COG2706	6-phosphogluconolactonase activity
S1361_RS05855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S1361_RS05865	COG0477	Major facilitator Superfamily
S1361_RS05895	COG1116	anion transmembrane transporter activity
S1361_RS05905	COG2072	flavoprotein involved in K transport
S1361_RS05910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S1361_RS05915	COG1132	(ABC) transporter
S1361_RS05950	COG1132	(ABC) transporter
S1361_RS05960	COG0254	rRNA binding
S1361_RS05975	COG1946	Acyl-CoA thioesterase
S1361_RS05985	COG2018	Roadblock/LC7 domain
S1361_RS06055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S1361_RS06080	COG1846	Transcriptional regulator
S1361_RS06080	COG1940	carbohydrate kinase activity
S1361_RS06100	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS06105	COG0366	Alpha amylase catalytic
S1361_RS06120	COG1653	transport
S1361_RS06125	COG1609	Transcriptional regulator
S1361_RS06135	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S1361_RS06140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S1361_RS06140	COG1017	nitric oxide dioxygenase activity
S1361_RS06175	COG0586	Pfam SNARE associated Golgi protein
S1361_RS06205	COG1960	acyl-CoA dehydrogenase activity
S1361_RS06210	COG1960	acyl-CoA dehydrogenase activity
S1361_RS06225	COG3634	alkyl hydroperoxide reductase activity
S1361_RS06230	COG1793	dna ligase
S1361_RS06250	COG3424	synthase
S1361_RS06255	COG2124	cytochrome p450
S1361_RS06275	COG2188	Transcriptional regulator
S1361_RS06645	COG0305	Participates in initiation and elongation during chromosome replication
S1361_RS06760	COG1960	acyl-CoA dehydrogenase activity
S1361_RS06770	COG0242	peptide deformylase activity
S1361_RS06780	COG3442	glutamine amidotransferase
S1361_RS06785	COG0205	6-phosphofructokinase activity
S1361_RS06800	COG1522	sequence-specific DNA binding
S1361_RS06805	COG1834	amidinotransferase
S1361_RS06810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S1361_RS06855	COG0204	Acyl-transferase
S1361_RS06870	COG0829	nickel cation binding
S1361_RS06875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S1361_RS06885	COG0804	urea catabolic process
S1361_RS06890	COG0832	Belongs to the urease beta subunit family
S1361_RS06895	COG0831	urea catabolic process
S1361_RS06905	COG0740	serine-type endopeptidase activity
S1361_RS06920	COG1280	lysine exporter protein (LysE YggA)
S1361_RS06925	COG0583	DNA-binding transcription factor activity
S1361_RS06950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S1361_RS06955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S1361_RS06960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S1361_RS06965	COG2226	methyltransferase
S1361_RS06980	COG0577	efflux transmembrane transporter activity
S1361_RS06980	COG1136	(ABC) transporter
S1361_RS07015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S1361_RS07020	COG3663	DNA glycosylase
S1361_RS07045	COG4585	Histidine kinase
S1361_RS07050	COG2197	response regulator
S1361_RS07055	COG1940	carbohydrate kinase activity
S1361_RS07065	COG1595	DNA-templated transcription, initiation
S1361_RS07090	COG0626	cystathionine gamma-synthase activity
S1361_RS07130	COG2197	response regulator
S1361_RS07150	COG1522	sequence-specific DNA binding
S1361_RS07165	COG0419	ATPase involved in DNA repair
S1361_RS07170	COG0420	3'-5' exonuclease activity
S1361_RS07175	COG1739	Uncharacterized protein family UPF0029
S1361_RS07195	COG1832	CoA-binding protein
S1361_RS07200	COG0531	amino acid
S1361_RS07210	COG0640	Transcriptional regulator
S1361_RS07240	COG0110	maltose O-acetyltransferase activity
S1361_RS07275	COG3321	synthase
S1361_RS07275	COG4221	oxidoreductase activity
S1361_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS07275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS07305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S1361_RS07320	COG0183	Belongs to the thiolase family
S1361_RS07330	COG1968	undecaprenyl-diphosphatase activity
S1361_RS07350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S1361_RS07355	COG0673	inositol 2-dehydrogenase activity
S1361_RS07365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S1361_RS07370	COG0747	negative chemotaxis
S1361_RS07405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS07425	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
S1361_RS07430	COG2197	response regulator
S1361_RS07455	COG0697	spore germination
S1361_RS07475	COG3655	Transcriptional regulator
S1361_RS07565	COG0395	ABC-type sugar transport system, permease component
S1361_RS07620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S1361_RS07620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S1361_RS07630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S1361_RS07650	COG1716	ATPase activity
S1361_RS07670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S1361_RS07700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S1361_RS07710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S1361_RS07740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S1361_RS07745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S1361_RS07765	COG2018	Roadblock/LC7 domain
S1361_RS07780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S1361_RS07785	COG2146	nitrite reductase [NAD(P)H] activity
S1361_RS07790	COG1414	Transcriptional regulator
S1361_RS07810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1361_RS07820	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS07855	COG2814	Major facilitator Superfamily
S1361_RS07860	COG4336	lyase activity
S1361_RS07865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S1361_RS07870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S1361_RS07875	COG1984	allophanate hydrolase subunit 2
S1361_RS07885	COG0438	transferase activity, transferring glycosyl groups
S1361_RS07915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS07920	COG2364	Membrane
S1361_RS07930	COG2270	Major facilitator Superfamily
S1361_RS07945	COG0463	Glycosyl transferase, family 2
S1361_RS07975	COG1960	acyl-CoA dehydrogenase activity
S1361_RS08035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S1361_RS08040	COG0140	phosphoribosyl-ATP diphosphatase activity
S1361_RS08045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S1361_RS08050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S1361_RS08050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S1361_RS08055	COG3201	nicotinamide mononucleotide transporter
S1361_RS08065	COG0702	epimerase
S1361_RS08075	COG1846	Transcriptional regulator
S1361_RS08075	COG1940	carbohydrate kinase activity
S1361_RS08080	COG0738	Major facilitator superfamily
S1361_RS08090	COG2233	PERMEase
S1361_RS08105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S1361_RS08130	COG0531	amino acid
S1361_RS08140	COG2390	Transcriptional regulator
S1361_RS08145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S1361_RS08155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S1361_RS08170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S1361_RS08185	COG0194	GDP metabolic process
S1361_RS08195	COG0284	orotidine-5'-phosphate decarboxylase activity
S1361_RS08200	COG0167	dihydroorotate dehydrogenase activity
S1361_RS08205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S1361_RS08210	COG0505	Belongs to the CarA family
S1361_RS08220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S1361_RS08225	COG0540	Belongs to the ATCase OTCase family
S1361_RS08230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S1361_RS08240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S1361_RS08245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S1361_RS08250	COG0006	proline dipeptidase activity
S1361_RS08260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S1361_RS08265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S1361_RS08270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S1361_RS08275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S1361_RS08280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S1361_RS08285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S1361_RS08290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S1361_RS08310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S1361_RS08325	COG0124	histidyl-tRNA synthetase
S1361_RS08335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S1361_RS08340	COG1196	nuclear chromosome segregation
S1361_RS08345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S1361_RS08350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S1361_RS08355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S1361_RS08360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S1361_RS08370	COG2255	four-way junction helicase activity
S1361_RS08375	COG0632	four-way junction helicase activity
S1361_RS08380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S1361_RS08385	COG0217	transcriptional regulatory protein
S1361_RS08390	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S1361_RS08395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S1361_RS08405	COG0438	transferase activity, transferring glycosyl groups
S1361_RS08410	COG1560	Kdo2-lipid A biosynthetic process
S1361_RS08415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S1361_RS08435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S1361_RS08440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S1361_RS08455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S1361_RS08470	COG0596	Alpha beta hydrolase
S1361_RS08520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S1361_RS08570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S1361_RS08570	COG1648	precorrin-2 dehydrogenase activity
S1361_RS08575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S1361_RS08590	COG1464	Belongs to the NlpA lipoprotein family
S1361_RS08595	COG2011	ABC-type metal ion transport system permease component
S1361_RS08600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S1361_RS08635	COG2132	Multicopper oxidase
S1361_RS08640	COG0477	Major facilitator Superfamily
S1361_RS08650	COG0667	Aldo Keto reductase
S1361_RS08655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S1361_RS08660	COG0165	Argininosuccinate lyase
S1361_RS08665	COG0137	argininosuccinate synthase activity
S1361_RS08700	COG2205	protein histidine kinase activity
S1361_RS08705	COG0745	RESPONSE REGULATOR receiver
S1361_RS08710	COG1017	nitric oxide dioxygenase activity
S1361_RS08710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S1361_RS08740	COG1132	(ABC) transporter
S1361_RS08760	COG1438	arginine binding
S1361_RS08765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S1361_RS08770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S1361_RS08775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S1361_RS08780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S1361_RS08790	COG0463	Glycosyl transferase, family 2
S1361_RS08825	COG0697	spore germination
S1361_RS08835	COG1649	PFAM Uncharacterised BCR, COG1649
S1361_RS08865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S1361_RS08865	COG0072	phenylalanine-tRNA ligase activity
S1361_RS08870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S1361_RS08875	COG5002	protein histidine kinase activity
S1361_RS08880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S1361_RS08885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S1361_RS08890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S1361_RS08895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S1361_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS08940	COG0174	glutamine synthetase
S1361_RS08950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S1361_RS08970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S1361_RS08980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S1361_RS08995	COG0564	pseudouridine synthase activity
S1361_RS09030	COG0805	protein transport
S1361_RS09035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S1361_RS09070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
S1361_RS09080	COG1609	Transcriptional regulator
S1361_RS09085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
S1361_RS09090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
S1361_RS09105	COG4122	O-methyltransferase activity
S1361_RS09110	COG1222	aaa ATPase
S1361_RS09130	COG0517	IMP dehydrogenase activity
S1361_RS09130	COG1994	Peptidase M50
S1361_RS09140	COG2197	response regulator
S1361_RS09145	COG0747	negative chemotaxis
S1361_RS09150	COG0747	negative chemotaxis
S1361_RS09155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S1361_RS09160	COG0646	methionine synthase
S1361_RS09160	COG1410	methionine synthase
S1361_RS09165	COG1414	Transcriptional regulator
S1361_RS09170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S1361_RS09175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S1361_RS09180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S1361_RS09185	COG2186	Transcriptional regulator
S1361_RS09195	COG0215	cysteine-tRNA ligase activity
S1361_RS09215	COG0598	Magnesium transport protein CorA
S1361_RS09225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS09230	COG0667	Aldo Keto reductase
S1361_RS09270	COG1796	DNA polymerase
S1361_RS09270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S1361_RS09290	COG3012	SEC-C Motif Domain Protein
S1361_RS09295	COG2186	Transcriptional regulator
S1361_RS09300	COG3265	gluconokinase activity
S1361_RS09330	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
S1361_RS09335	COG2149	membrane
S1361_RS09365	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS09375	COG3876	Protein conserved in bacteria
S1361_RS09430	COG1960	acyl-CoA dehydrogenase activity
S1361_RS09475	COG2851	Citrate transporter
S1361_RS09480	COG0243	molybdopterin cofactor binding
S1361_RS09485	COG1309	transcriptional regulator
S1361_RS09495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
S1361_RS09500	COG2188	Transcriptional regulator
S1361_RS09545	COG1595	DNA-templated transcription, initiation
S1361_RS09570	COG2755	lipolytic protein G-D-S-L family
S1361_RS09585	COG1725	Transcriptional regulator
S1361_RS09620	COG0587	DNA-directed DNA polymerase activity
S1361_RS09650	COG0765	amino acid transport
S1361_RS09665	COG1799	cell septum assembly
S1361_RS09670	COG1960	acyl-CoA dehydrogenase activity
S1361_RS09675	COG0477	Major facilitator Superfamily
S1361_RS09695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S1361_RS09700	COG1652	LysM domain
S1361_RS09715	COG1160	GTP binding
S1361_RS09725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S1361_RS09750	COG1397	ADP-ribosylglycohydrolase
S1361_RS09755	COG1187	pseudouridine synthase activity
S1361_RS09760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S1361_RS09765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S1361_RS09780	COG0686	Belongs to the AlaDH PNT family
S1361_RS09790	COG0494	nUDIX hydrolase
S1361_RS09795	COG0504	CTP synthase activity
S1361_RS09800	COG3387	PFAM Glycoside hydrolase 15-related
S1361_RS09815	COG0297	glycogen (starch) synthase activity
S1361_RS09820	COG0497	DNA recombination
S1361_RS09825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S1361_RS09845	COG1120	ATPase activity
S1361_RS09850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S1361_RS09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S1361_RS09860	COG0647	UMP catabolic process
S1361_RS09890	COG2094	Belongs to the DNA glycosylase MPG family
S1361_RS09900	COG1881	PFAM PEBP family protein
S1361_RS09920	COG1119	ATPase activity
S1361_RS09935	COG2197	response regulator
S1361_RS09950	COG1131	(ABC) transporter
S1361_RS09950	COG0842	Transport permease protein
S1361_RS09950	COG1716	ATPase activity
S1361_RS09955	COG0560	Phosphoserine phosphatase
S1361_RS09955	COG3830	Belongs to the UPF0237 family
S1361_RS09960	COG0588	phosphoglycerate mutase activity
S1361_RS09975	COG2186	Transcriptional regulator
S1361_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS10005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S1361_RS10025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S1361_RS10030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS10045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S1361_RS10050	COG1063	alcohol dehydrogenase
S1361_RS10065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S1361_RS10080	COG3387	PFAM Glycoside hydrolase 15-related
S1361_RS10090	COG1024	Enoyl-CoA hydratase
S1361_RS10100	COG0488	(ABC) transporter
S1361_RS10125	COG0235	Class ii aldolase
S1361_RS10150	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
S1361_RS10155	COG1492	cobalamin metabolic process
S1361_RS10175	COG1797	cobyrinic acid a,c-diamide synthase activity
S1361_RS10205	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S1361_RS10225	COG1126	abc transporter atp-binding protein
S1361_RS10230	COG0765	amino acid transport
S1361_RS10235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS10240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S1361_RS10245	COG0456	acetyltransferase
S1361_RS10250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S1361_RS10255	COG1917	Cupin 2, conserved barrel domain protein
S1361_RS10260	COG5285	phytanoyl-CoA dioxygenase
S1361_RS10290	COG1414	Transcriptional regulator
S1361_RS10300	COG0768	penicillin binding
S1361_RS10305	COG2252	PERMEase
S1361_RS10320	COG3209	COG3209 Rhs family protein
S1361_RS10370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS10375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S1361_RS10380	COG1349	DNA-binding transcription factor activity
S1361_RS10395	COG0395	ABC-type sugar transport system, permease component
S1361_RS10400	COG1063	alcohol dehydrogenase
S1361_RS10455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS10465	COG1595	DNA-templated transcription, initiation
S1361_RS10510	COG2171	N-acyltransferase activity
S1361_RS10515	COG3226	Transcriptional regulator
S1361_RS10520	COG2076	Multidrug Resistance protein
S1361_RS10530	COG2151	metal-sulfur cluster biosynthetic enzyme
S1361_RS10535	COG0822	iron-sulfur transferase activity
S1361_RS10540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S1361_RS10545	COG0396	ATPase activity
S1361_RS10555	COG0719	Fe-S assembly protein
S1361_RS10570	COG2746	aminoglycoside 3-N-acetyltransferase activity
S1361_RS10605	COG0109	protoheme IX farnesyltransferase activity
S1361_RS10615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S1361_RS10630	COG0363	glucosamine-6-phosphate deaminase activity
S1361_RS10635	COG0395	ABC-type sugar transport system, permease component
S1361_RS10640	COG1175	transmembrane transport
S1361_RS10645	COG1653	transport
S1361_RS10650	COG0366	Alpha amylase catalytic
S1361_RS10655	COG1653	transport
S1361_RS10660	COG1695	Transcriptional regulator
S1361_RS10665	COG1136	(ABC) transporter
S1361_RS10675	COG0166	Belongs to the GPI family
S1361_RS10690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S1361_RS10695	COG0149	triose-phosphate isomerase activity
S1361_RS10700	COG0126	phosphoglycerate kinase activity
S1361_RS10705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S1361_RS10715	COG1481	regulation of sporulation
S1361_RS10720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S1361_RS10725	COG1660	Displays ATPase and GTPase activities
S1361_RS10730	COG0322	excinuclease ABC activity
S1361_RS10755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S1361_RS10765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1361_RS10770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS10775	COG0765	amino acid transport
S1361_RS10785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S1361_RS10790	COG0477	Major facilitator Superfamily
S1361_RS10795	COG0387	Pfam Sodium calcium exchanger
S1361_RS10815	COG0556	nucleotide-excision repair
S1361_RS10825	COG0584	glycerophosphoryl diester phosphodiesterase
S1361_RS10830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S1361_RS10840	COG2313	pseudouridylate synthase activity
S1361_RS10850	COG2226	methyltransferase
S1361_RS10855	COG0598	Magnesium transport protein CorA
S1361_RS10885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1361_RS10890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS10950	COG2226	methyltransferase
S1361_RS10965	COG0237	dephospho-CoA kinase activity
S1361_RS10975	COG0539	negative regulation of cytoplasmic translation
S1361_RS10980	COG2226	methyltransferase
S1361_RS10985	COG1643	Atp-dependent helicase
S1361_RS11025	COG2050	protein possibly involved in aromatic compounds catabolism
S1361_RS11055	COG0411	ABC transporter
S1361_RS11080	COG0737	Belongs to the 5'-nucleotidase family
S1361_RS11095	COG0702	epimerase
S1361_RS11105	COG0287	Prephenate dehydrogenase
S1361_RS11105	COG1605	Chorismate mutase
S1361_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS11135	COG1024	Enoyl-CoA hydratase
S1361_RS11160	COG1309	transcriptional regulator
S1361_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS11170	COG1960	acyl-CoA dehydrogenase activity
S1361_RS11175	COG1960	acyl-CoA dehydrogenase activity
S1361_RS11180	COG2304	oxidoreductase activity
S1361_RS11190	COG0070	glutamate synthase
S1361_RS11190	COG0069	glutamate synthase activity
S1361_RS11190	COG0067	glutamate synthase
S1361_RS11220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S1361_RS11225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S1361_RS11230	COG2301	Belongs to the HpcH HpaI aldolase family
S1361_RS11235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S1361_RS11245	COG0159	tryptophan synthase activity
S1361_RS11250	COG0133	tryptophan synthase activity
S1361_RS11255	COG0134	indole-3-glycerol-phosphate synthase activity
S1361_RS11280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S1361_RS11290	COG0346	lactoylglutathione lyase activity
S1361_RS11300	COG0107	imidazoleglycerol-phosphate synthase activity
S1361_RS11305	COG0251	oxidation-reduction process
S1361_RS11310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S1361_RS11315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S1361_RS11325	COG0131	Imidazoleglycerol-phosphate dehydratase
S1361_RS11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S1361_RS11335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S1361_RS11355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S1361_RS11375	COG1432	Conserved Protein
S1361_RS11385	COG0587	DNA-directed DNA polymerase activity
S1361_RS11435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S1361_RS11445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S1361_RS11450	COG3599	regulation of cell shape
S1361_RS11460	COG1799	cell septum assembly
S1361_RS11470	COG1496	oxidoreductase activity
S1361_RS11475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S1361_RS11485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S1361_RS11495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S1361_RS11500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S1361_RS11510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S1361_RS11525	COG0275	rRNA processing
S1361_RS11535	COG0714	Associated with various cellular activities
S1361_RS11555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S1361_RS11565	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S1361_RS11575	COG1309	transcriptional regulator
S1361_RS11595	COG0352	thiamine-phosphate diphosphorylase activity
S1361_RS11605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S1361_RS11615	COG2022	thiamine diphosphate biosynthetic process
S1361_RS11615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1361_RS11625	COG2022	thiamine diphosphate biosynthetic process
S1361_RS11630	COG2815	serine threonine protein kinase
S1361_RS11630	COG0515	serine threonine protein kinase
S1361_RS11635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S1361_RS11645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S1361_RS11650	COG2193	ferroxidase activity
S1361_RS11655	COG0243	molybdopterin cofactor binding
S1361_RS11660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S1361_RS11675	COG0205	6-phosphofructokinase activity
S1361_RS11685	COG4585	Histidine kinase
S1361_RS11720	COG1940	carbohydrate kinase activity
S1361_RS11730	COG0003	Pfam Anion-transporting ATPase
S1361_RS11755	COG0438	transferase activity, transferring glycosyl groups
S1361_RS11810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S1361_RS11815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S1361_RS11820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S1361_RS11825	COG0723	plastoquinol--plastocyanin reductase activity
S1361_RS11830	COG2010	Cytochrome c
S1361_RS11835	COG1845	cytochrome c oxidase, subunit III
S1361_RS11845	COG1376	ErfK ybiS ycfS ynhG family protein
S1361_RS11855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S1361_RS11860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S1361_RS11870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S1361_RS11890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S1361_RS11895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S1361_RS11900	COG2197	response regulator
S1361_RS11905	COG4585	Histidine kinase
S1361_RS11930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S1361_RS11950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S1361_RS11955	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S1361_RS11955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S1361_RS11970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S1361_RS11975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S1361_RS11980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S1361_RS11985	COG0508	dehydrogenase complex catalyzes the overall conversion of
S1361_RS11995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
S1361_RS12010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S1361_RS12035	COG0321	lipoyl(octanoyl) transferase activity
S1361_RS12040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S1361_RS12070	COG2867	negative regulation of translational initiation
S1361_RS12075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S1361_RS12080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S1361_RS12090	COG0662	Cupin 2, conserved barrel domain protein
S1361_RS12110	COG0174	glutamine synthetase
S1361_RS12140	COG0501	Belongs to the peptidase M48B family
S1361_RS12180	COG0745	RESPONSE REGULATOR receiver
S1361_RS12195	COG2197	response regulator
S1361_RS12230	COG1309	transcriptional regulator
S1361_RS12250	COG0366	Alpha amylase catalytic
S1361_RS12255	COG3833	ABC-type maltose transport systems, permease component
S1361_RS12260	COG1175	transmembrane transport
S1361_RS12265	COG2182	Extracellular solute-binding protein
S1361_RS12270	COG1609	Transcriptional regulator
S1361_RS12280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S1361_RS12290	COG3511	phospholipase C
S1361_RS12345	COG0174	glutamine synthetase
S1361_RS12355	COG1959	2 iron, 2 sulfur cluster binding
S1361_RS12395	COG2814	Major facilitator Superfamily
S1361_RS12405	COG1309	transcriptional regulator
S1361_RS12410	COG0477	Major facilitator Superfamily
S1361_RS12415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S1361_RS12440	COG1994	Peptidase M50
S1361_RS12495	COG2837	iron assimilation
S1361_RS12500	COG0672	)-iron permease
S1361_RS12525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S1361_RS12530	COG2814	Major facilitator Superfamily
S1361_RS12555	COG2259	Doxx family
S1361_RS12565	COG2186	Transcriptional regulator
S1361_RS12570	COG1620	l-lactate permease
S1361_RS12575	COG0247	lactate metabolic process
S1361_RS12580	COG1139	Iron-sulfur cluster binding protein
S1361_RS12585	COG1556	Lactate utilization protein
S1361_RS12605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS12615	COG0431	NADPH-dependent FMN reductase
S1361_RS12630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS12635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S1361_RS12640	COG1116	anion transmembrane transporter activity
S1361_RS12645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S1361_RS12655	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S1361_RS12660	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS12665	COG2208	phosphoserine phosphatase activity
S1361_RS12705	COG0789	Transcriptional regulator
S1361_RS12715	COG3022	response to hydroperoxide
S1361_RS12720	COG0800	Aldolase
S1361_RS12735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S1361_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS12760	COG2030	dehydratase
S1361_RS12765	COG4585	Histidine kinase
S1361_RS12780	COG2197	response regulator
S1361_RS12795	COG0477	Major facilitator Superfamily
S1361_RS12805	COG2247	cell wall binding repeat
S1361_RS12805	COG0860	N-Acetylmuramoyl-L-alanine amidase
S1361_RS12815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS12840	COG0438	transferase activity, transferring glycosyl groups
S1361_RS12845	COG1309	transcriptional regulator
S1361_RS12870	COG1595	DNA-templated transcription, initiation
S1361_RS12875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1361_RS12885	COG3469	chitinase activity
S1361_RS12895	COG0494	nUDIX hydrolase
S1361_RS12900	COG3547	Transposase (IS116 IS110 IS902 family)
S1361_RS12960	COG3845	ABC transporter
S1361_RS12975	COG3619	membrane
S1361_RS12985	COG2124	cytochrome p450
S1361_RS12990	COG0183	Belongs to the thiolase family
S1361_RS13020	COG4122	O-methyltransferase activity
S1361_RS13060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S1361_RS13125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S1361_RS13140	COG1358	cellular component organization or biogenesis
S1361_RS13185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
S1361_RS13190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S1361_RS13200	COG0477	Major facilitator Superfamily
S1361_RS13205	COG1309	transcriptional regulator
S1361_RS13220	COG0789	Transcriptional regulator
S1361_RS13245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S1361_RS13250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S1361_RS13255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S1361_RS13285	COG1309	transcriptional regulator
S1361_RS13305	COG2130	NADP-dependent
S1361_RS13310	COG1764	response to oxidative stress
S1361_RS13325	COG4948	Mandelate Racemase Muconate Lactonizing
S1361_RS13350	COG4214	carbohydrate transport
S1361_RS13360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S1361_RS13370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S1361_RS13410	COG3386	PFAM SMP-30 Gluconolaconase
S1361_RS13415	COG1414	Transcriptional regulator
S1361_RS13435	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS13440	COG0825	malonyl-CoA metabolic process
S1361_RS13440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S1361_RS13445	COG1404	Belongs to the peptidase S8 family
S1361_RS13480	COG1077	Cell shape determining protein MreB Mrl
S1361_RS13500	COG0515	serine threonine protein kinase
S1361_RS13500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S1361_RS13525	COG2226	methyltransferase
S1361_RS13550	COG1070	Carbohydrate kinase
S1361_RS13565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S1361_RS13570	COG0358	DNA primase activity
S1361_RS13580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
S1361_RS13590	COG2949	membrane
S1361_RS13600	COG0243	molybdopterin cofactor binding
S1361_RS13640	COG0442	prolyl-tRNA aminoacylation
S1361_RS13645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S1361_RS13650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S1361_RS13650	COG2146	nitrite reductase [NAD(P)H] activity
S1361_RS13660	COG1309	transcriptional regulator
S1361_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS13690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S1361_RS13690	COG0574	Belongs to the PEP-utilizing enzyme family
S1361_RS13695	COG1940	carbohydrate kinase activity
S1361_RS13700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
S1361_RS13740	COG0477	Major facilitator Superfamily
S1361_RS13760	COG0423	glycine-tRNA ligase activity
S1361_RS13765	COG0803	Belongs to the bacterial solute-binding protein 9 family
S1361_RS13765	COG3443	Belongs to the bacterial solute-binding protein 9 family
S1361_RS13770	COG1121	(ABC) transporter
S1361_RS13775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S1361_RS13790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S1361_RS13795	COG1381	Involved in DNA repair and RecF pathway recombination
S1361_RS13800	COG0747	negative chemotaxis
S1361_RS13810	COG0444	Belongs to the ABC transporter superfamily
S1361_RS13815	COG4608	Belongs to the ABC transporter superfamily
S1361_RS13820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS13835	COG2409	Drug exporters of the RND superfamily
S1361_RS13845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S1361_RS13890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S1361_RS13925	COG2315	Protein conserved in bacteria
S1361_RS13935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S1361_RS13950	COG4948	Mandelate Racemase Muconate Lactonizing
S1361_RS13955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS13960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S1361_RS13965	COG1234	tRNA 3'-trailer cleavage
S1361_RS13970	COG0537	adenosine 5'-monophosphoramidase activity
S1361_RS13975	COG0793	Belongs to the peptidase S41A family
S1361_RS13975	COG4946	Tricorn protease homolog
S1361_RS14000	COG0484	heat shock protein binding
S1361_RS14005	COG1420	regulation of RNA biosynthetic process
S1361_RS14035	COG0481	GTPase activity
S1361_RS14040	COG0268	Binds directly to 16S ribosomal RNA
S1361_RS14055	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S1361_RS14065	COG1555	photosystem II stabilization
S1361_RS14070	COG1307	EDD domain protein, DegV family
S1361_RS14080	COG0495	leucyl-tRNA aminoacylation
S1361_RS14090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S1361_RS14115	COG0477	Major facilitator Superfamily
S1361_RS14130	COG0588	phosphoglycerate mutase activity
S1361_RS14145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S1361_RS14160	COG0501	Belongs to the peptidase M48B family
S1361_RS14175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S1361_RS14185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S1361_RS14195	COG1215	transferase activity, transferring glycosyl groups
S1361_RS14215	COG3540	Alkaline phosphatase
S1361_RS14220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S1361_RS14225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S1361_RS14230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S1361_RS14235	COG1530	ribonuclease E activity
S1361_RS14260	COG0477	Major facilitator Superfamily
S1361_RS14295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S1361_RS14310	COG0772	Belongs to the SEDS family
S1361_RS14315	COG0768	penicillin binding
S1361_RS14330	COG1077	Cell shape determining protein MreB Mrl
S1361_RS14335	COG0105	UTP biosynthetic process
S1361_RS14345	COG0285	dihydrofolate synthase activity
S1361_RS14350	COG0525	valine-tRNA ligase activity
S1361_RS14370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S1361_RS14375	COG0740	serine-type endopeptidase activity
S1361_RS14380	COG0740	serine-type endopeptidase activity
S1361_RS14385	COG0544	peptidyl-prolyl cis-trans isomerase activity
S1361_RS14420	COG3594	Acyltransferase
S1361_RS14435	COG4552	Acetyltransferase involved in intracellular survival and related
S1361_RS14450	COG1113	amino acid transport
S1361_RS14460	COG1940	carbohydrate kinase activity
S1361_RS14470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S1361_RS14475	COG1116	anion transmembrane transporter activity
S1361_RS14490	COG1113	amino acid transport
S1361_RS14495	COG0588	phosphoglycerate mutase activity
S1361_RS14500	COG1070	Carbohydrate kinase
S1361_RS14505	COG1349	DNA-binding transcription factor activity
S1361_RS14520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S1361_RS14535	COG2755	lipolytic protein G-D-S-L family
S1361_RS14615	COG1846	Transcriptional regulator
S1361_RS14620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S1361_RS14645	COG1595	DNA-templated transcription, initiation
S1361_RS14655	COG1131	(ABC) transporter
S1361_RS14675	COG0668	transmembrane transport
S1361_RS14695	COG1940	carbohydrate kinase activity
S1361_RS14705	COG1175	transmembrane transport
S1361_RS14710	COG0395	ABC-type sugar transport system, permease component
S1361_RS14715	COG1486	melibiose metabolic process
S1361_RS14725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S1361_RS14735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS14785	COG1136	(ABC) transporter
S1361_RS14825	COG0629	single-stranded DNA binding
S1361_RS14865	COG2304	oxidoreductase activity
S1361_RS14890	COG0438	transferase activity, transferring glycosyl groups
S1361_RS14915	COG0438	transferase activity, transferring glycosyl groups
S1361_RS14980	COG1131	(ABC) transporter
S1361_RS15000	COG3962	Belongs to the TPP enzyme family
S1361_RS15005	COG3718	enzyme involved in inositol metabolism
S1361_RS15015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S1361_RS15045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S1361_RS15075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S1361_RS15090	COG0673	inositol 2-dehydrogenase activity
S1361_RS15120	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S1361_RS15125	COG1472	Belongs to the glycosyl hydrolase 3 family
S1361_RS15170	COG0028	Belongs to the TPP enzyme family
S1361_RS15180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS15200	COG1946	Acyl-CoA thioesterase
S1361_RS15210	COG1309	transcriptional regulator
S1361_RS15215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S1361_RS15230	COG1960	acyl-CoA dehydrogenase activity
S1361_RS15245	COG0076	glutamate decarboxylase activity
S1361_RS15250	COG3486	L-lysine 6-monooxygenase (NADPH) activity
S1361_RS15285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S1361_RS15295	COG0589	response to stress
S1361_RS15305	COG4977	sequence-specific DNA binding
S1361_RS15310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
S1361_RS15345	COG3979	chitinase
S1361_RS15355	COG0745	RESPONSE REGULATOR receiver
S1361_RS15385	COG0406	alpha-ribazole phosphatase activity
S1361_RS15410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS15455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS15460	COG0765	amino acid transport
S1361_RS15465	COG0765	amino acid transport
S1361_RS15470	COG1126	abc transporter atp-binding protein
S1361_RS15490	COG3397	chitin binding
S1361_RS15510	COG2186	Transcriptional regulator
S1361_RS15540	COG0673	inositol 2-dehydrogenase activity
S1361_RS15545	COG4702	Belongs to the UPF0303 family
S1361_RS15560	COG0706	membrane insertase activity
S1361_RS15580	COG3764	Sortase (surface protein transpeptidase)
S1361_RS15595	COG0701	Predicted permease
S1361_RS15625	COG0071	Belongs to the small heat shock protein (HSP20) family
S1361_RS15645	COG2271	Major facilitator Superfamily
S1361_RS15650	COG2733	membrane
S1361_RS15660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S1361_RS15695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S1361_RS15710	COG4555	ABC transporter
S1361_RS15725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S1361_RS15730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S1361_RS15735	COG1263	PTS System
S1361_RS15740	COG1263	PTS System
S1361_RS15775	COG1113	amino acid transport
S1361_RS15785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S1361_RS15795	COG1335	isochorismatase
S1361_RS15815	COG1714	RDD family
S1361_RS15830	COG0277	FAD linked oxidase domain protein
S1361_RS15845	COG3185	4-Hydroxyphenylpyruvate dioxygenase
S1361_RS15860	COG4948	Mandelate Racemase Muconate Lactonizing
S1361_RS15875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S1361_RS15880	COG0531	amino acid
S1361_RS15905	COG1280	lysine exporter protein (LysE YggA)
S1361_RS15925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1361_RS15940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
S1361_RS15950	COG1678	Uncharacterized ACR, COG1678
S1361_RS15955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S1361_RS15960	COG0776	regulation of translation
S1361_RS15970	COG3973	AAA domain
S1361_RS15995	COG2223	nitrite transmembrane transporter activity
S1361_RS16015	COG0583	DNA-binding transcription factor activity
S1361_RS16030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S1361_RS16035	COG0793	Belongs to the peptidase S41A family
S1361_RS16040	COG2177	Part of the ABC transporter FtsEX involved in
S1361_RS16045	COG2884	Cell division ATP-binding protein ftsE
S1361_RS16060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S1361_RS16065	COG0515	serine threonine protein kinase
S1361_RS16070	COG0515	serine threonine protein kinase
S1361_RS16085	COG1175	transmembrane transport
S1361_RS16090	COG0395	ABC-type sugar transport system, permease component
S1361_RS16095	COG1216	Glycosyl transferase, family 2
S1361_RS16100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S1361_RS16105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S1361_RS16105	COG0463	Glycosyl transferase, family 2
S1361_RS16110	COG1764	response to oxidative stress
S1361_RS16115	COG1846	Transcriptional regulator
S1361_RS16130	COG1215	transferase activity, transferring glycosyl groups
S1361_RS16150	COG1134	teichoic acid transport
S1361_RS16155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S1361_RS16160	COG1215	transferase activity, transferring glycosyl groups
S1361_RS16170	COG2902	Dehydrogenase
S1361_RS16195	COG0653	protein targeting
S1361_RS16205	COG3214	Protein conserved in bacteria
S1361_RS16210	COG2197	response regulator
S1361_RS16215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S1361_RS16225	COG0823	Involved in the tonB-independent uptake of proteins
S1361_RS16230	COG5002	protein histidine kinase activity
S1361_RS16235	COG0745	RESPONSE REGULATOR receiver
S1361_RS16240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S1361_RS16260	COG0714	Associated with various cellular activities
S1361_RS16300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S1361_RS16305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S1361_RS16305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S1361_RS16305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S1361_RS16315	COG1482	cell wall glycoprotein biosynthetic process
S1361_RS16325	COG2835	tetraacyldisaccharide 4'-kinase activity
S1361_RS16365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S1361_RS16370	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
S1361_RS16370	COG0778	Nitroreductase
S1361_RS16395	COG1316	TRANSCRIPTIONal
S1361_RS16400	COG1316	TRANSCRIPTIONal
S1361_RS16405	COG1316	TRANSCRIPTIONal
S1361_RS16425	COG1316	TRANSCRIPTIONal
S1361_RS16440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S1361_RS16470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S1361_RS16485	COG2205	protein histidine kinase activity
S1361_RS16490	COG0745	RESPONSE REGULATOR receiver
S1361_RS16495	COG3104	oligopeptide transport
S1361_RS16525	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS16530	COG1191	sigma factor activity
S1361_RS16540	COG1228	amidohydrolase
S1361_RS16550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S1361_RS16555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S1361_RS16595	COG4221	oxidoreductase activity
S1361_RS16610	COG2755	lipolytic protein G-D-S-L family
S1361_RS16615	COG0183	Belongs to the thiolase family
S1361_RS16650	COG1136	(ABC) transporter
S1361_RS16650	COG0577	efflux transmembrane transporter activity
S1361_RS16655	COG0577	efflux transmembrane transporter activity
S1361_RS16660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S1361_RS16665	COG1252	NADH dehydrogenase
S1361_RS16685	COG0148	phosphopyruvate hydratase activity
S1361_RS16705	COG2124	cytochrome p450
S1361_RS16760	COG0577	efflux transmembrane transporter activity
S1361_RS16765	COG1136	(ABC) transporter
S1361_RS16770	COG0477	Major facilitator Superfamily
S1361_RS16780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS16815	COG4585	Histidine kinase
S1361_RS16830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S1361_RS16835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S1361_RS16840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S1361_RS16845	COG0193	aminoacyl-tRNA hydrolase activity
S1361_RS16855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
S1361_RS16865	COG1309	transcriptional regulator
S1361_RS16875	COG4106	trans-aconitate 2-methyltransferase activity
S1361_RS16885	COG2197	response regulator
S1361_RS16900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S1361_RS16940	COG0488	(ABC) transporter
S1361_RS16950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S1361_RS16955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S1361_RS16960	COG3583	domain protein
S1361_RS16960	COG3584	3D domain protein
S1361_RS16965	COG0084	hydrolase, TatD family'
S1361_RS16990	COG0768	penicillin binding
S1361_RS17000	COG0310	cobalt ion transport
S1361_RS17010	COG1122	ATPase activity
S1361_RS17015	COG1846	Transcriptional regulator
S1361_RS17020	COG1764	response to oxidative stress
S1361_RS17040	COG0442	prolyl-tRNA aminoacylation
S1361_RS17045	COG2409	Drug exporters of the RND superfamily
S1361_RS17055	COG0793	Belongs to the peptidase S41A family
S1361_RS17055	COG4946	Tricorn protease homolog
S1361_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS17070	COG2267	carboxylic ester hydrolase activity
S1361_RS17075	COG2072	flavoprotein involved in K transport
S1361_RS17085	COG0708	Exodeoxyribonuclease III
S1361_RS17090	COG0454	-acetyltransferase
S1361_RS17095	COG0697	spore germination
S1361_RS17100	COG0583	DNA-binding transcription factor activity
S1361_RS17115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S1361_RS17120	COG0315	cyclic pyranopterin monophosphate synthase activity
S1361_RS17120	COG0521	Mo-molybdopterin cofactor biosynthetic process
S1361_RS17125	COG0315	cyclic pyranopterin monophosphate synthase activity
S1361_RS17135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S1361_RS17140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S1361_RS17150	COG3263	regulation of cellular component size
S1361_RS17165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S1361_RS17175	COG1970	mechanosensitive ion channel activity
S1361_RS17190	COG3191	aminopeptidase activity
S1361_RS17205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S1361_RS17205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S1361_RS17205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S1361_RS17220	COG1349	DNA-binding transcription factor activity
S1361_RS17225	COG0477	Major facilitator Superfamily
S1361_RS17245	COG1247	-acetyltransferase
S1361_RS17250	COG3384	dioxygenase
S1361_RS17255	COG1846	Transcriptional regulator
S1361_RS17330	COG2188	Transcriptional regulator
S1361_RS17355	COG2255	four-way junction helicase activity
S1361_RS17365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
S1361_RS17480	COG0386	Belongs to the glutathione peroxidase family
S1361_RS17500	COG1686	Belongs to the peptidase S11 family
S1361_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS17545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
S1361_RS17570	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
S1361_RS17585	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
S1361_RS17610	COG3629	intracellular signal transduction
S1361_RS17610	COG3903	Transcriptional regulator
S1361_RS17635	COG1024	Enoyl-CoA hydratase
S1361_RS17645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S1361_RS17645	COG0515	serine threonine protein kinase
S1361_RS17655	COG1309	transcriptional regulator
S1361_RS17660	COG1522	sequence-specific DNA binding
S1361_RS17665	COG1280	lysine exporter protein (LysE YggA)
S1361_RS17690	COG1960	acyl-CoA dehydrogenase activity
S1361_RS17700	COG0259	pyridoxamine-phosphate oxidase activity
S1361_RS17715	COG2072	flavoprotein involved in K transport
S1361_RS17725	COG1024	Enoyl-CoA hydratase
S1361_RS17745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
S1361_RS17750	COG1960	acyl-CoA dehydrogenase activity
S1361_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS17770	COG1960	acyl-CoA dehydrogenase activity
S1361_RS17775	COG1960	acyl-CoA dehydrogenase activity
S1361_RS17785	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS17845	COG0596	Alpha beta hydrolase
S1361_RS17845	COG2945	thiolester hydrolase activity
S1361_RS17855	COG4821	SIS domain
S1361_RS17865	COG0259	pyridoxamine-phosphate oxidase activity
S1361_RS17880	COG1309	transcriptional regulator
S1361_RS17890	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS17905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S1361_RS17920	COG5006	permease, DMT superfamily
S1361_RS17930	COG0247	lactate metabolic process
S1361_RS17930	COG0277	FAD linked oxidase domain protein
S1361_RS17935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S1361_RS18000	COG0667	Aldo Keto reductase
S1361_RS18030	COG2252	PERMEase
S1361_RS18040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S1361_RS18070	COG2326	polyphosphate kinase activity
S1361_RS18100	COG2814	Major facilitator Superfamily
S1361_RS18110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S1361_RS18115	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
S1361_RS18120	COG1278	Cold shock
S1361_RS18150	COG1061	Type III restriction enzyme res subunit
S1361_RS18155	COG1231	oxidoreductase activity
S1361_RS18180	COG3973	AAA domain
S1361_RS18200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S1361_RS18215	COG1737	Transcriptional regulator
S1361_RS18220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S1361_RS18240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S1361_RS18260	COG0459	protein refolding
S1361_RS18265	COG1278	Cold shock
S1361_RS18280	COG0463	Glycosyl transferase, family 2
S1361_RS18285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
S1361_RS18315	COG1105	Belongs to the carbohydrate kinase PfkB family
S1361_RS18325	COG3300	MHYT domain
S1361_RS18325	COG5001	Diguanylate cyclase
S1361_RS18340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S1361_RS18380	COG0456	acetyltransferase
S1361_RS18400	COG3842	ATPase activity
S1361_RS18425	COG0215	cysteine-tRNA ligase activity
S1361_RS18435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S1361_RS18440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S1361_RS18445	COG1329	Transcriptional regulator
S1361_RS18465	COG0745	RESPONSE REGULATOR receiver
S1361_RS18475	COG5002	protein histidine kinase activity
S1361_RS18510	COG0438	transferase activity, transferring glycosyl groups
S1361_RS18515	COG0438	transferase activity, transferring glycosyl groups
S1361_RS18520	COG0588	phosphoglycerate mutase activity
S1361_RS18545	COG3415	Transposase
S1361_RS18545	COG2801	Transposase and inactivated derivatives
S1361_RS18620	COG0438	transferase activity, transferring glycosyl groups
S1361_RS18655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S1361_RS18665	COG1309	transcriptional regulator
S1361_RS18675	COG0546	phosphoglycolate phosphatase activity
S1361_RS18680	COG2186	Transcriptional regulator
S1361_RS18690	COG2188	Transcriptional regulator
S1361_RS18700	COG1490	D-aminoacyl-tRNA deacylase activity
S1361_RS18715	COG3485	protocatechuate 3,4-dioxygenase
S1361_RS18735	COG2897	thiosulfate sulfurtransferase activity
S1361_RS18775	COG0745	RESPONSE REGULATOR receiver
S1361_RS18780	COG1609	Transcriptional regulator
S1361_RS18785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S1361_RS18795	COG0745	RESPONSE REGULATOR receiver
S1361_RS18805	COG1846	Transcriptional regulator
S1361_RS18815	COG0737	Belongs to the 5'-nucleotidase family
S1361_RS18820	COG0456	acetyltransferase
S1361_RS18825	COG1725	Transcriptional regulator
S1361_RS18830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
S1361_RS18845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S1361_RS18855	COG0494	nUDIX hydrolase
S1361_RS18855	COG0406	alpha-ribazole phosphatase activity
S1361_RS18870	COG1937	Protein conserved in bacteria
S1361_RS18880	COG0306	phosphate transporter
S1361_RS18885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S1361_RS18905	COG0277	FAD linked oxidase domain protein
S1361_RS18915	COG0671	phosphoesterase, PA-phosphatase related
S1361_RS19015	COG1252	NADH dehydrogenase
S1361_RS19025	COG5434	Belongs to the glycosyl hydrolase 28 family
S1361_RS19045	COG0579	oxidoreductase
S1361_RS19050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S1361_RS19060	COG0667	Aldo Keto reductase
S1361_RS19080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S1361_RS19080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S1361_RS19090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S1361_RS19095	COG0477	Major facilitator Superfamily
S1361_RS19120	COG0513	Belongs to the DEAD box helicase family
S1361_RS19155	COG0582	viral genome integration into host DNA
S1361_RS19240	COG1643	Atp-dependent helicase
S1361_RS19275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S1361_RS19295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S1361_RS19300	COG0047	phosphoribosylformylglycinamidine synthase activity
S1361_RS19305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S1361_RS19340	COG2197	response regulator
S1361_RS19350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S1361_RS19365	COG0151	Belongs to the GarS family
S1361_RS19405	COG1276	copper resistance
S1361_RS19405	COG2372	response to copper ion
S1361_RS19450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S1361_RS19485	COG1191	sigma factor activity
S1361_RS19490	COG1191	sigma factor activity
S1361_RS19510	COG0477	Major facilitator Superfamily
S1361_RS19515	COG2353	YceI-like domain
S1361_RS19520	COG3467	pyridoxamine 5'-phosphate
S1361_RS19530	COG0477	Major facilitator Superfamily
S1361_RS19535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S1361_RS19545	COG2205	protein histidine kinase activity
S1361_RS19550	COG0745	RESPONSE REGULATOR receiver
S1361_RS19600	COG0784	Response regulator, receiver
S1361_RS19605	COG1309	transcriptional regulator
S1361_RS19610	COG2814	Major facilitator Superfamily
S1361_RS19615	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS19620	COG1595	DNA-templated transcription, initiation
S1361_RS19665	COG2226	methyltransferase
S1361_RS19680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S1361_RS19690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S1361_RS19705	COG0653	protein targeting
S1361_RS19725	COG0006	proline dipeptidase activity
S1361_RS19730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS19765	COG2837	iron assimilation
S1361_RS19770	COG0077	Prephenate dehydratase
S1361_RS19775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S1361_RS19780	COG0561	phosphatase activity
S1361_RS19815	COG1131	(ABC) transporter
S1361_RS19830	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
S1361_RS19840	COG0561	phosphatase activity
S1361_RS19845	COG4988	ABC transporter
S1361_RS19850	COG1294	oxidase, subunit
S1361_RS19855	COG1271	oxidase subunit
S1361_RS19865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S1361_RS19870	COG1609	Transcriptional regulator
S1361_RS19885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S1361_RS19910	COG0662	Cupin 2, conserved barrel domain protein
S1361_RS19915	COG1950	PFAM Membrane protein of
S1361_RS19920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S1361_RS19925	COG0626	cystathionine gamma-synthase activity
S1361_RS19950	COG2814	Major facilitator Superfamily
S1361_RS19970	COG0305	Participates in initiation and elongation during chromosome replication
S1361_RS19980	COG0359	binds to the 23S rRNA
S1361_RS19985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S1361_RS19990	COG0629	single-stranded DNA binding
S1361_RS19995	COG0360	Binds together with S18 to 16S ribosomal RNA
S1361_RS20020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S1361_RS20040	COG0617	tRNA 3'-terminal CCA addition
S1361_RS20055	COG2815	serine threonine protein kinase
S1361_RS20055	COG0515	serine threonine protein kinase
S1361_RS20060	COG1595	DNA-templated transcription, initiation
S1361_RS20070	COG0492	ferredoxin-NADP+ reductase activity
S1361_RS20075	COG3118	belongs to the thioredoxin family
S1361_RS20090	COG1192	Involved in chromosome partitioning
S1361_RS20095	COG0357	Ribosomal RNA small subunit methyltransferase G
S1361_RS20105	COG0706	membrane insertase activity
S1361_RS20110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S1361_RS20115	COG0594	ribonuclease P activity
S1361_RS20120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S1361_RS20130	COG0592	DNA-directed DNA polymerase activity
S1361_RS20135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S1361_RS20140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S1361_RS20145	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
S1361_RS20150	COG0187	DNA topoisomerase II activity
S1361_RS20155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S1361_RS20195	COG2319	Wd-40 repeat
S1361_RS20195	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS20230	COG0515	serine threonine protein kinase
S1361_RS20255	COG0705	Rhomboid family
S1361_RS20270	COG3764	Sortase (surface protein transpeptidase)
S1361_RS20285	COG3764	Sortase (surface protein transpeptidase)
S1361_RS20290	COG3764	Sortase (surface protein transpeptidase)
S1361_RS20295	COG0515	serine threonine protein kinase
S1361_RS20300	COG0768	penicillin binding
S1361_RS20315	COG1716	ATPase activity
S1361_RS20320	COG1716	ATPase activity
S1361_RS20340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS20345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS20355	COG0534	Mate efflux family protein
S1361_RS20360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S1361_RS20365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S1361_RS20410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S1361_RS20420	COG0436	Aminotransferase
S1361_RS20445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS20460	COG0506	proline dehydrogenase activity
S1361_RS20465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS20475	COG0019	diaminopimelate decarboxylase activity
S1361_RS20515	COG0583	DNA-binding transcription factor activity
S1361_RS20575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S1361_RS20580	COG2151	metal-sulfur cluster biosynthetic enzyme
S1361_RS20585	COG3396	Phenylacetate-CoA oxygenase
S1361_RS20590	COG3460	Phenylacetate-CoA oxygenase
S1361_RS20595	COG3396	Phenylacetate-CoA oxygenase
S1361_RS20620	COG1250	3-hydroxyacyl-CoA dehydrogenase
S1361_RS20625	COG1309	transcriptional regulator
S1361_RS20630	COG1522	sequence-specific DNA binding
S1361_RS20650	COG0746	molybdenum cofactor guanylyltransferase activity
S1361_RS20660	COG0604	alcohol dehydrogenase
S1361_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS20660	COG3321	synthase
S1361_RS20675	COG0515	serine threonine protein kinase
S1361_RS20680	COG0515	serine threonine protein kinase
S1361_RS20695	COG0022	dehydrogenase e1 component
S1361_RS20700	COG0508	dehydrogenase complex catalyzes the overall conversion of
S1361_RS20730	COG2814	Major facilitator Superfamily
S1361_RS20770	COG1362	aminopeptidase activity
S1361_RS20775	COG1960	acyl-CoA dehydrogenase activity
S1361_RS20785	COG1741	Belongs to the pirin family
S1361_RS20805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S1361_RS20815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S1361_RS20825	COG1289	transmembrane transporter activity
S1361_RS20835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S1361_RS20895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S1361_RS20900	COG1957	nucleoside hydrolase
S1361_RS20905	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
S1361_RS20910	COG0366	Alpha amylase catalytic
S1361_RS20950	COG0326	Molecular chaperone. Has ATPase activity
S1361_RS20985	COG2409	Drug exporters of the RND superfamily
S1361_RS21010	COG0513	Belongs to the DEAD box helicase family
S1361_RS21015	COG1278	Cold shock
S1361_RS21035	COG1595	DNA-templated transcription, initiation
S1361_RS21095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S1361_RS21145	COG0513	Belongs to the DEAD box helicase family
S1361_RS21150	COG1278	Cold shock
S1361_RS21220	COG0717	Belongs to the dCTP deaminase family
S1361_RS21225	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
S1361_RS21260	COG2181	nitrate reductase activity
S1361_RS21260	COG0247	lactate metabolic process
S1361_RS21265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S1361_RS21270	COG0443	Heat shock 70 kDa protein
S1361_RS21275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S1361_RS21280	COG0484	heat shock protein binding
S1361_RS21285	COG0789	Transcriptional regulator
S1361_RS21295	COG4213	ABC transporter substrate-binding protein
S1361_RS21325	COG0542	response to heat
S1361_RS21350	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S1361_RS21365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S1361_RS21375	COG0477	Major facilitator Superfamily
S1361_RS21390	COG3844	kynureninase activity
S1361_RS21410	COG4585	Histidine kinase
S1361_RS21415	COG2197	response regulator
S1361_RS21420	COG4585	Histidine kinase
S1361_RS21425	COG2197	response regulator
S1361_RS21430	COG3209	COG3209 Rhs family protein
S1361_RS21460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S1361_RS21475	COG1802	Transcriptional regulator
S1361_RS21480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S1361_RS21495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S1361_RS21500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S1361_RS21520	COG1595	DNA-templated transcription, initiation
S1361_RS21550	COG0701	Predicted permease
S1361_RS21630	COG1408	metallophosphoesterase
S1361_RS21640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S1361_RS21650	COG0003	Pfam Anion-transporting ATPase
S1361_RS21675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1361_RS21705	COG2267	carboxylic ester hydrolase activity
S1361_RS21720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S1361_RS21785	COG1111	helicase
S1361_RS21785	COG1205	dead DEAH box helicase
S1361_RS21790	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS21800	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
S1361_RS21820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S1361_RS21820	COG1754	DNA topoisomerase type I activity
S1361_RS21825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S1361_RS21900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S1361_RS21900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S1361_RS21925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S1361_RS21930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S1361_RS21935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S1361_RS21940	COG0254	rRNA binding
S1361_RS21950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S1361_RS21985	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS21990	COG2318	DinB family
S1361_RS22000	COG0076	glutamate decarboxylase activity
S1361_RS22010	COG0789	Transcriptional regulator
S1361_RS22015	COG0586	Pfam SNARE associated Golgi protein
S1361_RS22025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
S1361_RS22030	COG2027	D-alanyl-D-alanine carboxypeptidase
S1361_RS22040	COG0037	tRNA processing
S1361_RS22055	COG0302	gtp cyclohydrolase
S1361_RS22070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S1361_RS22085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S1361_RS22085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S1361_RS22110	COG0649	NAD binding
S1361_RS22125	COG2197	response regulator
S1361_RS22150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S1361_RS22155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S1361_RS22165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S1361_RS22185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S1361_RS22210	COG0739	heme binding
S1361_RS22235	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S1361_RS22240	COG2205	protein histidine kinase activity
S1361_RS22245	COG0745	RESPONSE REGULATOR receiver
S1361_RS22255	COG1595	DNA-templated transcription, initiation
S1361_RS22270	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S1361_RS22290	COG0248	Ppx GppA phosphatase
S1361_RS22295	COG1082	Xylose isomerase domain protein TIM barrel
S1361_RS22300	COG1309	transcriptional regulator
S1361_RS22305	COG0129	dihydroxy-acid dehydratase activity
S1361_RS22315	COG4991	sh3 domain protein
S1361_RS22330	COG0842	Transport permease protein
S1361_RS22330	COG1129	ABC transporter
S1361_RS22340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S1361_RS22345	COG0180	Tryptophanyl-tRNA synthetase
S1361_RS22365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S1361_RS22375	COG2223	nitrite transmembrane transporter activity
S1361_RS22380	COG0123	including yeast histone deacetylase and acetoin utilization protein
S1361_RS22430	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S1361_RS22435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S1361_RS22440	COG0181	hydroxymethylbilane synthase activity
S1361_RS22445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S1361_RS22445	COG1648	precorrin-2 dehydrogenase activity
S1361_RS22500	COG2124	cytochrome p450
S1361_RS22505	COG0477	Major facilitator Superfamily
S1361_RS22510	COG0113	porphobilinogen synthase activity
S1361_RS22540	COG0018	arginyl-trna synthetase
S1361_RS22545	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
S1361_RS22565	COG1690	Belongs to the RtcB family
S1361_RS22590	COG1742	UPF0060 membrane protein
S1361_RS22600	COG1733	regulation of RNA biosynthetic process
S1361_RS22610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS22615	COG0431	NADPH-dependent FMN reductase
S1361_RS22625	COG2205	protein histidine kinase activity
S1361_RS22635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S1361_RS22635	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S1361_RS22645	COG2362	D-Aminopeptidase
S1361_RS22735	COG2226	methyltransferase
S1361_RS22750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S1361_RS22755	COG0406	alpha-ribazole phosphatase activity
S1361_RS22765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S1361_RS22770	COG0785	Cytochrome C biogenesis protein
S1361_RS22775	COG1333	cytochrome c biogenesis protein
S1361_RS22780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S1361_RS22810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S1361_RS22825	COG0163	prenyltransferase activity
S1361_RS22835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
S1361_RS22840	COG1573	uracil-dna glycosylase
S1361_RS22855	COG1309	transcriptional regulator
S1361_RS22870	COG2226	methyltransferase
S1361_RS22895	COG1278	Cold shock
S1361_RS22900	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
S1361_RS22910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
S1361_RS22925	COG2226	methyltransferase
S1361_RS22945	COG0242	peptide deformylase activity
S1361_RS22960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS22965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS22970	COG0649	NAD binding
S1361_RS22980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S1361_RS22985	COG1034	ATP synthesis coupled electron transport
S1361_RS22990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S1361_RS22995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS23000	COG0839	Belongs to the complex I subunit 6 family
S1361_RS23005	COG0713	ATP synthesis coupled electron transport
S1361_RS23010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S1361_RS23020	COG1007	ATP synthesis coupled electron transport
S1361_RS23035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S1361_RS23040	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
S1361_RS23060	COG2188	Transcriptional regulator
S1361_RS23085	COG0561	phosphatase activity
S1361_RS23090	COG5412	phage tail tape measure protein
S1361_RS23090	COG3953	SLT domain
S1361_RS23095	COG0142	geranyltranstransferase activity
S1361_RS23105	COG1131	(ABC) transporter
S1361_RS23135	COG0702	epimerase
S1361_RS23140	COG1733	regulation of RNA biosynthetic process
S1361_RS23145	COG1013	pyruvate-flavodoxin oxidoreductase activity
S1361_RS23150	COG0674	pyruvate-flavodoxin oxidoreductase activity
S1361_RS23150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
S1361_RS23170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS23175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS23180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS23185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S1361_RS23190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS23195	COG0839	Belongs to the complex I subunit 6 family
S1361_RS23200	COG0713	ATP synthesis coupled electron transport
S1361_RS23210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS23215	COG1007	ATP synthesis coupled electron transport
S1361_RS23220	COG0501	Belongs to the peptidase M48B family
S1361_RS23225	COG3304	Inner membrane component domain
S1361_RS23235	COG2261	transglycosylase associated protein
S1361_RS23240	COG1666	GTP binding
S1361_RS23265	COG0702	epimerase
S1361_RS23285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S1361_RS23290	COG2030	dehydratase
S1361_RS23310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S1361_RS23315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S1361_RS23325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S1361_RS23330	COG0436	Aminotransferase
S1361_RS23345	COG0250	Participates in transcription elongation, termination and antitermination
S1361_RS23360	COG0081	regulation of translation
S1361_RS23380	COG0085	RNA polymerase activity
S1361_RS23385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S1361_RS23400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S1361_RS23405	COG0049	tRNA binding
S1361_RS23410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S1361_RS23480	COG0051	transcription antitermination factor activity, RNA binding
S1361_RS23485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S1361_RS23490	COG0088	Forms part of the polypeptide exit tunnel
S1361_RS23495	COG0089	rRNA binding
S1361_RS23500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S1361_RS23505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S1361_RS23510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S1361_RS23515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S1361_RS23520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S1361_RS23525	COG0255	Belongs to the universal ribosomal protein uL29 family
S1361_RS23530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S1361_RS23535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S1361_RS23540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S1361_RS23545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S1361_RS23550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S1361_RS23555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S1361_RS23560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S1361_RS23565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S1361_RS23570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S1361_RS23575	COG1841	ribosomal large subunit assembly
S1361_RS23580	COG0200	Binds to the 23S rRNA
S1361_RS23590	COG0563	adenylate kinase activity
S1361_RS23600	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S1361_RS23605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S1361_RS23610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S1361_RS23615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S1361_RS23620	COG0202	RNA polymerase activity
S1361_RS23625	COG0203	ribosomal protein L17
S1361_RS23630	COG0101	tRNA pseudouridine synthase activity
S1361_RS23655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S1361_RS23660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S1361_RS23665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S1361_RS23675	COG1072	(Pantothenic acid kinase))
S1361_RS23680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S1361_RS23690	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS23695	COG0736	holo-[acyl-carrier-protein] synthase activity
S1361_RS23705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S1361_RS23715	COG0802	atpase or kinase
S1361_RS23735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S1361_RS23750	COG1609	Transcriptional regulator
S1361_RS23770	COG4941	Belongs to the sigma-70 factor family
S1361_RS23780	COG0726	polysaccharide deacetylase
S1361_RS23785	COG0726	polysaccharide deacetylase
S1361_RS23795	COG0459	protein refolding
S1361_RS23805	COG4221	oxidoreductase activity
S1361_RS23815	COG0583	DNA-binding transcription factor activity
S1361_RS23830	COG1595	DNA-templated transcription, initiation
S1361_RS23840	COG0516	GMP reductase activity
S1361_RS23850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S1361_RS23865	COG2815	serine threonine protein kinase
S1361_RS23865	COG0515	serine threonine protein kinase
S1361_RS23870	COG0515	serine threonine protein kinase
S1361_RS23875	COG0515	serine threonine protein kinase
S1361_RS23875	COG2815	serine threonine protein kinase
S1361_RS23880	COG0515	serine threonine protein kinase
S1361_RS23890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
S1361_RS23900	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS23915	COG0519	Catalyzes the synthesis of GMP from XMP
S1361_RS23915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S1361_RS23960	COG2197	response regulator
S1361_RS24000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS24000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS24015	COG0714	Associated with various cellular activities
S1361_RS24030	COG3552	Protein containing von Willebrand factor type A (VWA) domain
S1361_RS24035	COG0045	succinate-CoA ligase (ADP-forming) activity
S1361_RS24065	COG0138	bifunctional purine biosynthesis protein purh
S1361_RS24075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S1361_RS24085	COG4585	Histidine kinase
S1361_RS24090	COG2197	response regulator
S1361_RS24100	COG0039	L-malate dehydrogenase activity
S1361_RS24110	COG0477	Major facilitator Superfamily
S1361_RS24125	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS24135	COG0517	IMP dehydrogenase activity
S1361_RS24135	COG4175	Glycine betaine
S1361_RS24155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1361_RS24160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS24180	COG0754	glutathionylspermidine amidase activity
S1361_RS24195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S1361_RS24200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S1361_RS24205	COG0180	Tryptophanyl-tRNA synthetase
S1361_RS24220	COG1295	ribonuclease BN
S1361_RS24235	COG1408	metallophosphoesterase
S1361_RS24250	COG1309	transcriptional regulator
S1361_RS24275	COG1053	succinate dehydrogenase
S1361_RS24285	COG2009	succinate dehydrogenase
S1361_RS24295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
S1361_RS24335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S1361_RS24355	COG1595	DNA-templated transcription, initiation
S1361_RS24370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS24370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS24400	COG1216	Glycosyl transferase, family 2
S1361_RS24415	COG2089	acid synthase
S1361_RS24455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S1361_RS24455	COG1473	amidohydrolase
S1361_RS24460	COG1744	ABC transporter substrate-binding protein PnrA-like
S1361_RS24465	COG3845	ABC transporter
S1361_RS24470	COG4603	Belongs to the binding-protein-dependent transport system permease family
S1361_RS24475	COG1079	Belongs to the binding-protein-dependent transport system permease family
S1361_RS24510	COG2814	Major facilitator Superfamily
S1361_RS24515	COG0583	DNA-binding transcription factor activity
S1361_RS24525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S1361_RS24545	COG2205	protein histidine kinase activity
S1361_RS24550	COG0745	RESPONSE REGULATOR receiver
S1361_RS24555	COG1595	DNA-templated transcription, initiation
S1361_RS24565	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS24570	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS24575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S1361_RS24590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S1361_RS24615	COG4770	biotin carboxylase activity
S1361_RS24625	COG0424	maF-like protein
S1361_RS24635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S1361_RS24645	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S1361_RS24655	COG1024	Enoyl-CoA hydratase
S1361_RS24665	COG2986	histidine ammonia-lyase
S1361_RS24690	COG1404	Belongs to the peptidase S8 family
S1361_RS24700	COG1064	alcohol dehydrogenase
S1361_RS24715	COG0501	Belongs to the peptidase M48B family
S1361_RS24735	COG1595	DNA-templated transcription, initiation
S1361_RS24740	COG2255	four-way junction helicase activity
S1361_RS24745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S1361_RS24760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S1361_RS24770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S1361_RS24800	COG1331	Highly conserved protein containing a thioredoxin domain
S1361_RS24825	COG1309	transcriptional regulator
S1361_RS24835	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
S1361_RS24845	COG0436	Aminotransferase
S1361_RS24865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
S1361_RS24880	COG1414	Transcriptional regulator
S1361_RS24885	COG0251	oxidation-reduction process
S1361_RS24890	COG2610	gluconate transmembrane transporter activity
S1361_RS24960	COG2894	cell division
S1361_RS24990	COG3920	Histidine kinase
S1361_RS25015	COG2885	chlorophyll binding
S1361_RS25040	COG2226	methyltransferase
S1361_RS25045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S1361_RS25050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S1361_RS25055	COG0741	lytic transglycosylase activity
S1361_RS25065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1361_RS25070	COG0450	alkyl hydroperoxide reductase
S1361_RS25085	COG1136	(ABC) transporter
S1361_RS25105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S1361_RS25120	COG0114	fumarate hydratase activity
S1361_RS25125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
S1361_RS25125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S1361_RS25150	COG0778	Nitroreductase
S1361_RS25155	COG1722	exodeoxyribonuclease VII activity
S1361_RS25160	COG1570	exodeoxyribonuclease VII activity
S1361_RS25165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S1361_RS25180	COG0012	GTP binding
S1361_RS25245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S1361_RS25250	COG1053	succinate dehydrogenase
S1361_RS25270	COG1217	gtp-binding protein TYPA
S1361_RS25275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S1361_RS25280	COG4166	transmembrane transport
S1361_RS25285	COG0601	transmembrane transport
S1361_RS25290	COG0444	Belongs to the ABC transporter superfamily
S1361_RS25295	COG4608	Belongs to the ABC transporter superfamily
S1361_RS25330	COG4608	Belongs to the ABC transporter superfamily
S1361_RS25335	COG0444	Belongs to the ABC transporter superfamily
S1361_RS25345	COG0747	negative chemotaxis
S1361_RS25350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S1361_RS25360	COG0601	transmembrane transport
S1361_RS25365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S1361_RS25375	COG4608	Belongs to the ABC transporter superfamily
S1361_RS25390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S1361_RS25405	COG1131	(ABC) transporter
S1361_RS25415	COG4585	Histidine kinase
S1361_RS25420	COG2197	response regulator
S1361_RS25455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S1361_RS25460	COG1611	Belongs to the LOG family
S1361_RS25465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S1361_RS25475	COG0519	Catalyzes the synthesis of GMP from XMP
S1361_RS25480	COG1024	Enoyl-CoA hydratase
S1361_RS25495	COG1595	DNA-templated transcription, initiation
S1361_RS25505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S1361_RS25510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S1361_RS25540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
S1361_RS25550	COG0598	Magnesium transport protein CorA
S1361_RS25560	COG2814	Major facilitator Superfamily
S1361_RS25570	COG0613	PHP domain protein
S1361_RS25575	COG2095	MarC family integral membrane protein
S1361_RS25585	COG1432	Conserved Protein
S1361_RS25635	COG4166	transmembrane transport
S1361_RS25640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S1361_RS25650	COG4172	Belongs to the ABC transporter superfamily
S1361_RS25685	COG0596	Alpha beta hydrolase
S1361_RS25715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S1361_RS25720	COG2816	NAD+ diphosphatase activity
S1361_RS25755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
S1361_RS25810	COG3480	Lon protease (S16) C-terminal proteolytic domain
S1361_RS25820	COG1615	UPF0182 protein
S1361_RS25845	COG0753	catalase activity
S1361_RS25855	COG0483	inositol monophosphate 1-phosphatase activity
S1361_RS25865	COG2076	Multidrug Resistance protein
S1361_RS25875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S1361_RS25895	COG2135	peptidase activity
S1361_RS25905	COG1595	DNA-templated transcription, initiation
S1361_RS25910	COG5662	AntiSigma factor
S1361_RS25930	COG0242	peptide deformylase activity
S1361_RS25940	COG2124	cytochrome p450
S1361_RS25980	COG2188	Transcriptional regulator
S1361_RS25985	COG0363	glucosamine-6-phosphate deaminase activity
S1361_RS26000	COG1597	lipid kinase activity
S1361_RS26015	COG2172	sigma factor antagonist activity
S1361_RS26040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S1361_RS26045	COG0142	geranyltranstransferase activity
S1361_RS26095	COG4106	trans-aconitate 2-methyltransferase activity
S1361_RS26105	COG1126	abc transporter atp-binding protein
S1361_RS26110	COG0765	amino acid transport
S1361_RS26115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS26120	COG0281	malic enzyme
S1361_RS26125	COG0604	alcohol dehydrogenase
S1361_RS26150	COG0508	dehydrogenase complex catalyzes the overall conversion of
S1361_RS26150	COG0567	Dehydrogenase, E1 component
S1361_RS26155	COG2205	protein histidine kinase activity
S1361_RS26160	COG0745	RESPONSE REGULATOR receiver
S1361_RS26175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S1361_RS26265	COG0768	penicillin binding
S1361_RS26270	COG0772	Belongs to the SEDS family
S1361_RS26275	COG2205	protein histidine kinase activity
S1361_RS26295	COG1793	dna ligase
S1361_RS26295	COG3285	dna ligase
S1361_RS26300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S1361_RS26320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S1361_RS26335	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S1361_RS26340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S1361_RS26350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S1361_RS26370	COG2188	Transcriptional regulator
S1361_RS26380	COG2188	Transcriptional regulator
S1361_RS26450	COG0018	arginyl-trna synthetase
S1361_RS26455	COG0019	diaminopimelate decarboxylase activity
S1361_RS26460	COG0460	homoserine dehydrogenase
S1361_RS26465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S1361_RS26470	COG0083	homoserine kinase activity
S1361_RS26480	COG1404	Belongs to the peptidase S8 family
S1361_RS26495	COG0254	rRNA binding
S1361_RS26500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S1361_RS26505	COG2890	protein-(glutamine-N5) methyltransferase activity
S1361_RS26515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S1361_RS26520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S1361_RS26525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S1361_RS26540	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S1361_RS26545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S1361_RS26550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S1361_RS26555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S1361_RS26560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S1361_RS26565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S1361_RS26570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S1361_RS26585	COG2197	response regulator
S1361_RS26590	COG4585	Histidine kinase
S1361_RS26600	COG2318	DinB family
S1361_RS26625	COG1250	3-hydroxyacyl-CoA dehydrogenase
S1361_RS26640	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
S1361_RS26675	COG1131	(ABC) transporter
S1361_RS26705	COG0183	Belongs to the thiolase family
S1361_RS26785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS26785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS26820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S1361_RS26825	COG0280	phosphate acetyltransferase
S1361_RS26825	COG0857	belongs to the CobB CobQ family
S1361_RS26830	COG0205	6-phosphofructokinase activity
S1361_RS26840	COG0395	ABC-type sugar transport system, permease component
S1361_RS26845	COG1175	transmembrane transport
S1361_RS26870	COG3903	Transcriptional regulator
S1361_RS26870	COG3629	intracellular signal transduction
S1361_RS26875	COG4565	transcriptional regulatory protein
S1361_RS26880	COG3290	protein histidine kinase activity
S1361_RS26885	COG1301	dicarboxylic acid transport
S1361_RS26895	COG0477	Major facilitator Superfamily
S1361_RS26910	COG0492	ferredoxin-NADP+ reductase activity
S1361_RS26910	COG3118	belongs to the thioredoxin family
S1361_RS26925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S1361_RS26930	COG3281	Trehalose synthase
S1361_RS26940	COG0366	Alpha amylase catalytic
S1361_RS26945	COG0058	SHG alpha-glucan phosphorylase activity
S1361_RS26970	COG4566	intracellular signal transduction
S1361_RS27000	COG1132	(ABC) transporter
S1361_RS27005	COG1132	(ABC) transporter
S1361_RS27035	COG1376	ErfK ybiS ycfS ynhG family protein
S1361_RS27040	COG1376	ErfK ybiS ycfS ynhG family protein
S1361_RS27075	COG1119	ATPase activity
S1361_RS27080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S1361_RS27090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S1361_RS27110	COG1191	sigma factor activity
S1361_RS27115	COG1760	l-serine dehydratase
S1361_RS27120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S1361_RS27125	COG0509	glycine decarboxylation via glycine cleavage system
S1361_RS27130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S1361_RS27150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S1361_RS27155	COG0747	negative chemotaxis
S1361_RS27165	COG0444	Belongs to the ABC transporter superfamily
S1361_RS27170	COG4608	Belongs to the ABC transporter superfamily
S1361_RS27175	COG2860	membrane
S1361_RS27195	COG2378	regulation of single-species biofilm formation
S1361_RS27225	COG0482	sulfurtransferase activity
S1361_RS27240	COG1611	Belongs to the LOG family
S1361_RS27245	COG4221	oxidoreductase activity
S1361_RS27260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S1361_RS27285	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S1361_RS27290	COG0154	amidase activity
S1361_RS27300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S1361_RS27310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S1361_RS27325	COG2197	response regulator
S1361_RS27330	COG2133	pyrroloquinoline quinone binding
S1361_RS27335	COG0667	Aldo Keto reductase
S1361_RS27345	COG5001	Diguanylate cyclase
S1361_RS27355	COG0440	acetolactate synthase activity
S1361_RS27360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S1361_RS27365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S1361_RS27370	COG0477	Major facilitator Superfamily
S1361_RS27385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS27395	COG0506	proline dehydrogenase activity
S1361_RS27400	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS27420	COG0473	3-isopropylmalate dehydrogenase activity
S1361_RS27425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S1361_RS27435	COG0831	urea catabolic process
S1361_RS27435	COG0832	Belongs to the urease beta subunit family
S1361_RS27440	COG0804	urea catabolic process
S1361_RS27445	COG2957	Belongs to the agmatine deiminase family
S1361_RS27455	COG0477	Major facilitator Superfamily
S1361_RS27460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S1361_RS27520	COG2353	YceI-like domain
S1361_RS27530	COG5492	domain, Protein
S1361_RS27535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S1361_RS27560	COG2018	Roadblock/LC7 domain
S1361_RS27580	COG2018	Roadblock/LC7 domain
S1361_RS27585	COG5002	protein histidine kinase activity
S1361_RS27595	COG0179	Fumarylacetoacetate (FAA) hydrolase
S1361_RS27600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S1361_RS27650	COG1414	Transcriptional regulator
S1361_RS27655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S1361_RS27660	COG0066	3-isopropylmalate dehydratase activity
S1361_RS27670	COG0776	regulation of translation
S1361_RS27685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S1361_RS27690	COG1181	Belongs to the D-alanine--D-alanine ligase family
S1361_RS27710	COG0351	phosphomethylpyrimidine kinase
S1361_RS27725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S1361_RS27730	COG1461	Dihydroxyacetone kinase
S1361_RS27740	COG0326	Molecular chaperone. Has ATPase activity
S1361_RS27750	COG0742	ribosomal rna small subunit methyltransferase
S1361_RS27755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S1361_RS27770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S1361_RS27775	COG0571	ribonuclease III activity
S1361_RS27780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S1361_RS27785	COG1733	regulation of RNA biosynthetic process
S1361_RS27790	COG0655	NAD(P)H dehydrogenase (quinone) activity
S1361_RS27805	COG2340	Cysteine-rich secretory protein family
S1361_RS27810	COG1254	Belongs to the acylphosphatase family
S1361_RS27820	COG1196	nuclear chromosome segregation
S1361_RS27825	COG0477	Major facilitator Superfamily
S1361_RS27870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S1361_RS27880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S1361_RS27895	COG0228	four-way junction DNA binding
S1361_RS27900	COG1837	Belongs to the UPF0109 family
S1361_RS27905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S1361_RS27910	COG0336	Belongs to the RNA methyltransferase TrmD family
S1361_RS27915	COG0335	large ribosomal subunit rRNA binding
S1361_RS27925	COG0681	Belongs to the peptidase S26 family
S1361_RS27930	COG0681	Belongs to the peptidase S26 family
S1361_RS27940	COG1051	belongs to the nudix hydrolase family
S1361_RS27950	COG0792	nuclease activity
S1361_RS27965	COG1191	sigma factor activity
S1361_RS27980	COG0052	Belongs to the universal ribosomal protein uS2 family
S1361_RS27985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S1361_RS27990	COG0528	UMP kinase activity
S1361_RS27995	COG0233	cytoplasmic translational termination
S1361_RS28000	COG0575	Belongs to the CDS family
S1361_RS28005	COG2124	cytochrome p450
S1361_RS28025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S1361_RS28035	COG4208	sulfate ABC transporter
S1361_RS28040	COG3842	ATPase activity
S1361_RS28070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S1361_RS28080	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS28090	COG0395	ABC-type sugar transport system, permease component
S1361_RS28095	COG1175	transmembrane transport
S1361_RS28110	COG3876	Protein conserved in bacteria
S1361_RS28125	COG1733	regulation of RNA biosynthetic process
S1361_RS28135	COG0584	glycerophosphoryl diester phosphodiesterase
S1361_RS28140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S1361_RS28165	COG3842	ATPase activity
S1361_RS28170	COG1176	ABC-type spermidine putrescine transport system, permease component I
S1361_RS28175	COG1177	transmembrane transport
S1361_RS28180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1361_RS28220	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS28245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S1361_RS28250	COG0750	zinc metalloprotease
S1361_RS28255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S1361_RS28265	COG1247	-acetyltransferase
S1361_RS28270	COG0442	prolyl-tRNA aminoacylation
S1361_RS28295	COG0779	Required for maturation of 30S ribosomal subunits
S1361_RS28310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S1361_RS28320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S1361_RS28325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S1361_RS28340	COG0455	bacterial-type flagellum organization
S1361_RS28355	COG3266	domain, Protein
S1361_RS28365	COG1404	Belongs to the peptidase S8 family
S1361_RS28380	COG1404	Belongs to the peptidase S8 family
S1361_RS28400	COG1674	ftsk spoiiie
S1361_RS28415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S1361_RS28420	COG1185	polyribonucleotide nucleotidyltransferase activity
S1361_RS28425	COG0612	Peptidase, M16
S1361_RS28430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S1361_RS28450	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
S1361_RS28455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS28460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S1361_RS28490	COG2770	Histidine kinase
S1361_RS28490	COG2208	phosphoserine phosphatase activity
S1361_RS28495	COG0784	Response regulator, receiver
S1361_RS28495	COG2205	protein histidine kinase activity
S1361_RS28505	COG1674	ftsk spoiiie
S1361_RS28515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S1361_RS28525	COG1058	Belongs to the CinA family
S1361_RS28525	COG1546	Belongs to the CinA family
S1361_RS28530	COG1396	sequence-specific DNA binding
S1361_RS28535	COG0783	Belongs to the Dps family
S1361_RS28550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S1361_RS28555	COG1201	RNA secondary structure unwinding
S1361_RS28585	COG0628	permease
S1361_RS28590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S1361_RS28645	COG0765	amino acid transport
S1361_RS28650	COG0765	amino acid transport
S1361_RS28655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS28660	COG1126	abc transporter atp-binding protein
S1361_RS28665	COG0745	RESPONSE REGULATOR receiver
S1361_RS28670	COG2205	protein histidine kinase activity
S1361_RS28675	COG2358	TRAP transporter, solute receptor (TAXI family
S1361_RS28705	COG0475	glutathione-regulated potassium exporter activity
S1361_RS28725	COG4221	oxidoreductase activity
S1361_RS28730	COG0583	DNA-binding transcription factor activity
S1361_RS28735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S1361_RS28755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S1361_RS28765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S1361_RS28770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S1361_RS28780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S1361_RS28810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S1361_RS28815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S1361_RS28820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S1361_RS28835	COG0588	phosphoglycerate mutase activity
S1361_RS28855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S1361_RS28895	COG1802	Transcriptional regulator
S1361_RS28900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S1361_RS28915	COG0187	DNA topoisomerase II activity
S1361_RS28930	COG2197	response regulator
S1361_RS28940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS28955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S1361_RS28965	COG4565	transcriptional regulatory protein
S1361_RS28970	COG3290	protein histidine kinase activity
S1361_RS28985	COG0372	Belongs to the citrate synthase family
S1361_RS28995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S1361_RS29000	COG0612	Peptidase, M16
S1361_RS29015	COG1802	Transcriptional regulator
S1361_RS29020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S1361_RS29025	COG0045	succinate-CoA ligase (ADP-forming) activity
S1361_RS29025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S1361_RS29025	COG1042	CoA-binding domain protein
S1361_RS29040	COG1435	thymidine kinase activity
S1361_RS29070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S1361_RS29085	COG0745	RESPONSE REGULATOR receiver
S1361_RS29090	COG2205	protein histidine kinase activity
S1361_RS29115	COG0756	dUTP diphosphatase activity
S1361_RS29125	COG1136	(ABC) transporter
S1361_RS29155	COG0569	domain protein
S1361_RS29165	COG0531	amino acid
S1361_RS29170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S1361_RS29190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S1361_RS29200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS29205	COG0069	glutamate synthase activity
S1361_RS29210	COG0017	Asparaginyl-tRNA synthetase
S1361_RS29305	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S1361_RS29315	COG3251	PFAM MbtH domain protein
S1361_RS29365	COG1132	(ABC) transporter
S1361_RS29375	COG0577	efflux transmembrane transporter activity
S1361_RS29375	COG1136	(ABC) transporter
S1361_RS29380	COG4585	Histidine kinase
S1361_RS29385	COG2197	response regulator
S1361_RS29395	COG0590	tRNA wobble adenosine to inosine editing
S1361_RS29400	COG3224	Antibiotic biosynthesis monooxygenase
S1361_RS29415	COG1191	sigma factor activity
S1361_RS29430	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS29435	COG2172	sigma factor antagonist activity
S1361_RS29450	COG1295	ribonuclease BN
S1361_RS29450	COG1959	2 iron, 2 sulfur cluster binding
S1361_RS29475	COG0702	epimerase
S1361_RS29525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S1361_RS29530	COG2423	ornithine cyclodeaminase activity
S1361_RS29540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S1361_RS29545	COG1280	lysine exporter protein (LysE YggA)
S1361_RS29590	COG1799	cell septum assembly
S1361_RS29630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S1361_RS29675	COG2235	arginine
S1361_RS29680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S1361_RS29685	COG0531	amino acid
S1361_RS29695	COG1024	Enoyl-CoA hydratase
S1361_RS29700	COG1902	pentaerythritol trinitrate reductase activity
S1361_RS29730	COG2188	Transcriptional regulator
S1361_RS29735	COG2182	Extracellular solute-binding protein
S1361_RS29740	COG1175	transmembrane transport
S1361_RS29745	COG0395	ABC-type sugar transport system, permease component
S1361_RS29750	COG1472	Belongs to the glycosyl hydrolase 3 family
S1361_RS29780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S1361_RS29795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S1361_RS29815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S1361_RS29845	COG1295	ribonuclease BN
S1361_RS29850	COG0628	permease
S1361_RS29880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S1361_RS29910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S1361_RS29955	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS29970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS29970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS30050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S1361_RS30060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S1361_RS30075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S1361_RS30080	COG0443	Heat shock 70 kDa protein
S1361_RS30085	COG0484	heat shock protein binding
S1361_RS30095	COG3537	Alpha-1,2-mannosidase
S1361_RS30105	COG1653	transport
S1361_RS30110	COG1175	transmembrane transport
S1361_RS30115	COG0395	ABC-type sugar transport system, permease component
S1361_RS30120	COG1940	carbohydrate kinase activity
S1361_RS30125	COG4213	ABC transporter substrate-binding protein
S1361_RS30140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S1361_RS30145	COG0531	amino acid
S1361_RS30165	COG1024	Enoyl-CoA hydratase
S1361_RS30165	COG1250	3-hydroxyacyl-CoA dehydrogenase
S1361_RS30170	COG0183	Belongs to the thiolase family
S1361_RS30175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
S1361_RS30190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S1361_RS30205	COG0446	pyridine nucleotide-disulphide oxidoreductase
S1361_RS30220	COG3253	May function as heme-dependent peroxidase
S1361_RS30240	COG3220	belongs to the UPF0276 family
S1361_RS30255	COG1121	(ABC) transporter
S1361_RS30275	COG0723	plastoquinol--plastocyanin reductase activity
S1361_RS30275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1361_RS30280	COG2326	polyphosphate kinase activity
S1361_RS30285	COG0330	HflC and HflK could
S1361_RS30320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S1361_RS30325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S1361_RS30345	COG1174	glycine betaine transport
S1361_RS30365	COG2018	Roadblock/LC7 domain
S1361_RS30370	COG5002	protein histidine kinase activity
S1361_RS30430	COG0504	CTP synthase activity
S1361_RS30435	COG0583	DNA-binding transcription factor activity
S1361_RS30475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S1361_RS30480	COG0583	DNA-binding transcription factor activity
S1361_RS30525	COG1175	transmembrane transport
S1361_RS30550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S1361_RS30555	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S1361_RS30595	COG1100	Small GTP-binding protein
S1361_RS30610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S1361_RS30615	COG1116	anion transmembrane transporter activity
S1361_RS30615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S1361_RS30640	COG0529	Catalyzes the synthesis of activated sulfate
S1361_RS30645	COG0175	sulfate reduction
S1361_RS30675	COG1960	acyl-CoA dehydrogenase activity
S1361_RS30695	COG3739	integral membrane protein
S1361_RS30715	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S1361_RS30740	COG2040	homocysteine
S1361_RS30755	COG0596	Alpha beta hydrolase
S1361_RS30800	COG3693	PFAM glycoside hydrolase, family 10
S1361_RS30805	COG1162	GTPase activity
S1361_RS30815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S1361_RS30850	COG1802	Transcriptional regulator
S1361_RS30875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1361_RS30880	COG2252	PERMEase
S1361_RS30900	COG5634	Uncharacterized conserved protein (DUF2278)
S1361_RS30905	COG0726	polysaccharide deacetylase
S1361_RS30915	COG0515	serine threonine protein kinase
S1361_RS30930	COG1653	transport
S1361_RS30960	COG2197	response regulator
S1361_RS30965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S1361_RS30970	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS31025	COG3960	tartronate-semialdehyde synthase activity
S1361_RS31040	COG0753	catalase activity
S1361_RS31045	COG2084	Dehydrogenase
S1361_RS31050	COG3622	Belongs to the hyi family
S1361_RS31100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S1361_RS31135	COG2351	hydroxyisourate hydrolase activity
S1361_RS31150	COG2233	PERMEase
S1361_RS31165	COG1733	regulation of RNA biosynthetic process
S1361_RS31180	COG0406	alpha-ribazole phosphatase activity
S1361_RS31195	COG0436	Aminotransferase
S1361_RS31200	COG1733	regulation of RNA biosynthetic process
S1361_RS31215	COG4264	IucA IucC family
S1361_RS31230	COG3629	intracellular signal transduction
S1361_RS31230	COG3903	Transcriptional regulator
S1361_RS31240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S1361_RS31255	COG1414	Transcriptional regulator
S1361_RS31260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S1361_RS31265	COG4266	Belongs to the allantoicase family
S1361_RS31285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1361_RS31295	COG0473	3-isopropylmalate dehydrogenase activity
S1361_RS31295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S1361_RS31305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S1361_RS31310	COG1053	succinate dehydrogenase
S1361_RS31310	COG3976	FMN-binding domain protein
S1361_RS31325	COG0583	DNA-binding transcription factor activity
S1361_RS31360	COG0640	Transcriptional regulator
S1361_RS31375	COG2197	response regulator
S1361_RS31385	COG0673	inositol 2-dehydrogenase activity
S1361_RS31390	COG2188	Transcriptional regulator
S1361_RS31410	COG1940	carbohydrate kinase activity
S1361_RS31420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S1361_RS31430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS31440	COG0745	RESPONSE REGULATOR receiver
S1361_RS31450	COG2814	Major facilitator Superfamily
S1361_RS31465	COG0789	Transcriptional regulator
S1361_RS31470	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS31485	COG0189	ligase activity
S1361_RS31490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S1361_RS31495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S1361_RS31500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S1361_RS31500	COG0519	Catalyzes the synthesis of GMP from XMP
S1361_RS31505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S1361_RS31510	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS31515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS31525	COG2814	Major facilitator Superfamily
S1361_RS31570	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS31570	COG2319	Wd-40 repeat
S1361_RS31585	COG1733	regulation of RNA biosynthetic process
S1361_RS31610	COG1132	(ABC) transporter
S1361_RS31625	COG3511	phospholipase C
S1361_RS31665	COG1191	sigma factor activity
S1361_RS31695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S1361_RS31700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S1361_RS31730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S1361_RS31730	COG2124	cytochrome p450
S1361_RS31800	COG1473	amidohydrolase
S1361_RS31805	COG2860	membrane
S1361_RS31865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
S1361_RS31880	COG1012	belongs to the aldehyde dehydrogenase family
S1361_RS31880	COG1454	alcohol dehydrogenase
S1361_RS31895	COG0516	GMP reductase activity
S1361_RS31895	COG0517	IMP dehydrogenase activity
S1361_RS31905	COG0531	amino acid
S1361_RS31920	COG0549	Belongs to the carbamate kinase family
S1361_RS31950	COG2326	polyphosphate kinase activity
S1361_RS31955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S1361_RS31960	COG4191	Histidine kinase
S1361_RS31965	COG1042	CoA-binding domain protein
S1361_RS31965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S1361_RS31965	COG0045	succinate-CoA ligase (ADP-forming) activity
S1361_RS31970	COG0517	IMP dehydrogenase activity
S1361_RS31970	COG0516	GMP reductase activity
S1361_RS31985	COG0589	response to stress
S1361_RS32010	COG0517	IMP dehydrogenase activity
S1361_RS32010	COG0516	GMP reductase activity
S1361_RS32035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1361_RS32070	COG0405	Gamma-glutamyltransferase
S1361_RS32075	COG0542	response to heat
S1361_RS32100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S1361_RS32115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S1361_RS32120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS32125	COG1953	Uracil, thiamine, allantoin
S1361_RS32170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
S1361_RS32170	COG2308	Evidence 4 Homologs of previously reported genes of
S1361_RS32185	COG0514	ATP-dependent DNA helicase (RecQ)
S1361_RS32200	COG0483	inositol monophosphate 1-phosphatase activity
S1361_RS32235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S1361_RS32250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S1361_RS32265	COG1929	Belongs to the glycerate kinase type-1 family
S1361_RS32275	COG0688	phosphatidylethanolamine metabolic process
S1361_RS32280	COG1960	acyl-CoA dehydrogenase activity
S1361_RS32295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS32295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
S1361_RS32310	COG1250	3-hydroxyacyl-CoA dehydrogenase
S1361_RS32320	COG0456	acetyltransferase
S1361_RS32350	COG2208	phosphoserine phosphatase activity
S1361_RS32350	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS32350	COG2172	sigma factor antagonist activity
S1361_RS32355	COG4106	trans-aconitate 2-methyltransferase activity
S1361_RS32360	COG2362	D-Aminopeptidase
S1361_RS32365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S1361_RS32375	COG1619	proteins homologs of microcin C7 resistance protein MccF
S1361_RS32395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS32410	COG3285	dna ligase
S1361_RS32410	COG1793	dna ligase
S1361_RS32470	COG0671	phosphoesterase, PA-phosphatase related
S1361_RS32475	COG0488	(ABC) transporter
S1361_RS32490	COG0693	protein deglycase activity
S1361_RS32505	COG0028	Belongs to the TPP enzyme family
S1361_RS32575	COG2154	pterin-4-alpha-carbinolamine dehydratase
S1361_RS32580	COG2226	methyltransferase
S1361_RS32590	COG5297	Belongs to the glycosyl hydrolase family 6
S1361_RS32590	COG4733	cellulase activity
S1361_RS32600	COG5297	Belongs to the glycosyl hydrolase family 6
S1361_RS32610	COG4221	oxidoreductase activity
S1361_RS32645	COG1022	Amp-dependent synthetase and ligase
S1361_RS32650	COG0583	DNA-binding transcription factor activity
S1361_RS32670	COG1846	Transcriptional regulator
S1361_RS32675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S1361_RS32680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S1361_RS32710	COG2124	cytochrome p450
S1361_RS32755	COG1132	(ABC) transporter
S1361_RS32795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S1361_RS32805	COG2182	Extracellular solute-binding protein
S1361_RS32810	COG1175	transmembrane transport
S1361_RS32815	COG0395	ABC-type sugar transport system, permease component
S1361_RS32820	COG2723	6-phospho-beta-galactosidase activity
S1361_RS32850	COG0297	glycogen (starch) synthase activity
S1361_RS32865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S1361_RS32890	COG0477	Major facilitator Superfamily
S1361_RS32900	COG3467	pyridoxamine 5'-phosphate
S1361_RS32905	COG2084	Dehydrogenase
S1361_RS32920	COG0588	phosphoglycerate mutase activity
S1361_RS32925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S1361_RS32930	COG0166	Belongs to the GPI family
S1361_RS32945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S1361_RS32965	COG2130	NADP-dependent
S1361_RS32975	COG1486	melibiose metabolic process
S1361_RS32980	COG3469	chitinase activity
S1361_RS32990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S1361_RS33030	COG1175	transmembrane transport
S1361_RS33035	COG0395	ABC-type sugar transport system, permease component
S1361_RS33040	COG0366	Alpha amylase catalytic
S1361_RS33050	COG3511	phospholipase C
S1361_RS33080	COG1672	PFAM Archaeal ATPase
S1361_RS33080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S1361_RS33095	COG1793	dna ligase
S1361_RS33130	COG1834	amidinotransferase
S1361_RS33135	COG0488	(ABC) transporter
S1361_RS33160	COG1515	deoxyribonuclease V activity
S1361_RS33170	COG3268	Saccharopine dehydrogenase
S1361_RS33175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
S1361_RS33180	COG0183	Belongs to the thiolase family
S1361_RS33185	COG1250	3-hydroxyacyl-CoA dehydrogenase
S1361_RS33185	COG1024	Enoyl-CoA hydratase
S1361_RS33195	COG1113	amino acid transport
S1361_RS33200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S1361_RS33210	COG2936	dipeptidyl-peptidase activity
S1361_RS33220	COG0488	(ABC) transporter
S1361_RS33225	COG2318	DinB family
S1361_RS33230	COG2183	response to ionizing radiation
S1361_RS33235	COG1024	Enoyl-CoA hydratase
S1361_RS33245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
S1361_RS33290	COG1134	teichoic acid transport
S1361_RS33295	COG1562	ergosterol biosynthetic process
S1361_RS33305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S1361_RS33315	COG1657	PFAM Prenyltransferase squalene oxidase
S1361_RS33330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S1361_RS33335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S1361_RS33365	COG4942	peptidase
S1361_RS33370	COG2755	lipolytic protein G-D-S-L family
S1361_RS33425	COG1063	alcohol dehydrogenase
S1361_RS33430	COG0156	8-amino-7-oxononanoate synthase activity
S1361_RS33435	COG0583	DNA-binding transcription factor activity
S1361_RS33460	COG3958	Transketolase
S1361_RS33465	COG3959	Transketolase, thiamine diphosphate binding domain
S1361_RS33495	COG0561	phosphatase activity
S1361_RS33520	COG2267	carboxylic ester hydrolase activity
S1361_RS33525	COG0183	Belongs to the thiolase family
S1361_RS33530	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS33540	COG1011	Hydrolase
S1361_RS33615	COG0395	ABC-type sugar transport system, permease component
S1361_RS33625	COG1653	transport
S1361_RS33655	COG0673	inositol 2-dehydrogenase activity
S1361_RS33670	COG0673	inositol 2-dehydrogenase activity
S1361_RS33720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS33725	COG3275	phosphorelay sensor kinase activity
S1361_RS33740	COG0531	amino acid
S1361_RS33750	COG3938	Belongs to the proline racemase family
S1361_RS33755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1361_RS33760	COG0446	pyridine nucleotide-disulphide oxidoreductase
S1361_RS33770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1361_RS33785	COG0765	amino acid transport
S1361_RS33790	COG1126	abc transporter atp-binding protein
S1361_RS33800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS33805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS33815	COG2197	response regulator
S1361_RS33845	COG2838	Isocitrate dehydrogenase
S1361_RS33860	COG0668	transmembrane transport
S1361_RS33865	COG0531	amino acid
S1361_RS33875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S1361_RS33890	COG1024	Enoyl-CoA hydratase
S1361_RS33910	COG1132	(ABC) transporter
S1361_RS33920	COG2080	2 iron, 2 sulfur cluster binding
S1361_RS33925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S1361_RS33930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1361_RS33950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S1361_RS34095	COG3321	synthase
S1361_RS34095	COG0604	alcohol dehydrogenase
S1361_RS34100	COG3321	synthase
S1361_RS34100	COG0604	alcohol dehydrogenase
S1361_RS34110	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
S1361_RS34120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S1361_RS34125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S1361_RS34135	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S1361_RS34165	COG0546	phosphoglycolate phosphatase activity
S1361_RS34185	COG0475	glutathione-regulated potassium exporter activity
S1361_RS34190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S1361_RS34235	COG1695	Transcriptional regulator
S1361_RS34250	COG0517	IMP dehydrogenase activity
S1361_RS34290	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS34330	COG1960	acyl-CoA dehydrogenase activity
S1361_RS34335	COG0513	Belongs to the DEAD box helicase family
S1361_RS34355	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S1361_RS34370	COG3629	intracellular signal transduction
S1361_RS34385	COG2197	response regulator
S1361_RS34430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S1361_RS34520	COG0010	Belongs to the arginase family
S1361_RS34555	COG0667	Aldo Keto reductase
S1361_RS34585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S1361_RS34595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S1361_RS34615	COG0297	glycogen (starch) synthase activity
S1361_RS34620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S1361_RS34630	COG3537	Alpha-1,2-mannosidase
S1361_RS34655	COG0154	amidase activity
S1361_RS34660	COG1609	Transcriptional regulator
S1361_RS34670	COG1175	transmembrane transport
S1361_RS34675	COG0395	ABC-type sugar transport system, permease component
S1361_RS34720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S1361_RS34750	COG0531	amino acid
S1361_RS34765	COG0726	polysaccharide deacetylase
S1361_RS34800	COG0583	DNA-binding transcription factor activity
S1361_RS34820	COG1053	succinate dehydrogenase
S1361_RS34825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S1361_RS34865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S1361_RS34875	COG3360	Dodecin
S1361_RS34880	COG2182	Extracellular solute-binding protein
S1361_RS34885	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
S1361_RS34890	COG0121	glutamine amidotransferase
S1361_RS34895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S1361_RS34935	COG2268	Band 7 protein
S1361_RS34980	COG1609	Transcriptional regulator
S1361_RS34985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S1361_RS34995	COG0242	peptide deformylase activity
S1361_RS35010	COG3336	cytochrome c oxidase
S1361_RS35050	COG0745	RESPONSE REGULATOR receiver
S1361_RS35055	COG5002	protein histidine kinase activity
S1361_RS35070	COG2124	cytochrome p450
S1361_RS35075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S1361_RS35085	COG2197	response regulator
S1361_RS35090	COG3851	Histidine kinase
S1361_RS35100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S1361_RS35110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S1361_RS35140	COG0542	response to heat
S1361_RS35145	COG1174	glycine betaine transport
S1361_RS35165	COG1556	Lactate utilization protein
S1361_RS35170	COG1139	Iron-sulfur cluster binding protein
S1361_RS35175	COG0247	lactate metabolic process
S1361_RS35205	COG1357	PFAM Pentapeptide repeats (8 copies)
S1361_RS35215	COG1309	transcriptional regulator
S1361_RS35225	COG2706	6-phosphogluconolactonase activity
S1361_RS35245	COG1846	Transcriptional regulator
S1361_RS35245	COG1940	carbohydrate kinase activity
S1361_RS35260	COG0546	phosphoglycolate phosphatase activity
S1361_RS35265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S1361_RS35265	COG1796	DNA polymerase
S1361_RS35270	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS35315	COG1006	Multisubunit Na H antiporter MnhC subunit
S1361_RS35320	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1361_RS35370	COG0435	Glutathione S-transferase
S1361_RS35385	COG2124	cytochrome p450
S1361_RS35400	COG0667	Aldo Keto reductase
S1361_RS35435	COG1595	DNA-templated transcription, initiation
S1361_RS35475	COG2890	protein-(glutamine-N5) methyltransferase activity
S1361_RS35490	COG4221	oxidoreductase activity
S1361_RS35500	COG0726	polysaccharide deacetylase
S1361_RS35560	COG2124	cytochrome p450
S1361_RS35585	COG3251	PFAM MbtH domain protein
S1361_RS35610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S1361_RS35620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S1361_RS35645	COG0247	lactate metabolic process
S1361_RS35645	COG0277	FAD linked oxidase domain protein
S1361_RS35655	COG0300	oxidoreductase activity
S1361_RS35670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S1361_RS35670	COG3608	succinylglutamate desuccinylase aspartoacylase
S1361_RS35705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S1361_RS35720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S1361_RS35750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS35820	COG1309	transcriptional regulator
S1361_RS35850	COG0701	Predicted permease
S1361_RS35920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
S1361_RS35935	COG3387	PFAM Glycoside hydrolase 15-related
S1361_RS35950	COG3290	protein histidine kinase activity
S1361_RS36010	COG2264	protein methyltransferase activity
S1361_RS36020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S1361_RS36050	COG0584	glycerophosphoryl diester phosphodiesterase
S1361_RS36085	COG0667	Aldo Keto reductase
S1361_RS36090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S1361_RS36115	COG3469	chitinase activity
S1361_RS36130	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS36145	COG2814	Major facilitator Superfamily
S1361_RS36150	COG0248	Ppx GppA phosphatase
S1361_RS36195	COG1982	Orn Lys Arg decarboxylase major
S1361_RS36215	COG2172	sigma factor antagonist activity
S1361_RS36220	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS36225	COG1366	Belongs to the anti-sigma-factor antagonist family
S1361_RS36280	COG0583	DNA-binding transcription factor activity
S1361_RS36315	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS36330	COG0596	Alpha beta hydrolase
S1361_RS36345	COG2755	lipolytic protein G-D-S-L family
S1361_RS36355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S1361_RS36380	COG2226	methyltransferase
S1361_RS36390	COG0640	Transcriptional regulator
S1361_RS36410	COG0667	Aldo Keto reductase
S1361_RS36430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1361_RS36485	COG1177	transmembrane transport
S1361_RS36490	COG1176	ABC-type spermidine putrescine transport system, permease component I
S1361_RS36495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
S1361_RS36500	COG3842	ATPase activity
S1361_RS36515	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S1361_RS36520	COG1733	regulation of RNA biosynthetic process
S1361_RS36540	COG3795	YCII-related domain
S1361_RS36545	COG4941	Belongs to the sigma-70 factor family
S1361_RS36555	COG0488	(ABC) transporter
S1361_RS36575	COG0277	FAD linked oxidase domain protein
S1361_RS36580	COG1597	lipid kinase activity
S1361_RS36595	COG0542	response to heat
S1361_RS36615	COG1316	TRANSCRIPTIONal
S1361_RS36630	COG2409	Drug exporters of the RND superfamily
S1361_RS36645	COG0477	Major facilitator Superfamily
S1361_RS36655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1361_RS36755	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S1361_RS36765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S1361_RS36800	COG0326	Molecular chaperone. Has ATPase activity
S1361_RS36810	COG0583	DNA-binding transcription factor activity
S1361_RS36815	COG1028	Short-chain dehydrogenase reductase Sdr
S1361_RS36850	COG3831	ATPase activity
S1361_RS36855	COG0714	Associated with various cellular activities
S1361_RS36860	COG3552	Protein containing von Willebrand factor type A (VWA) domain
S1361_RS36880	COG0477	Major facilitator Superfamily
S1361_RS36895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S1361_RS36925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S1361_RS36930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S1361_RS36985	COG1506	peptidase
S1361_RS36985	COG0823	Involved in the tonB-independent uptake of proteins
S1361_RS37030	COG0596	Alpha beta hydrolase
S1361_RS37100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S1361_RS37145	COG0589	response to stress
S1361_RS37220	COG0318	PFAM AMP-dependent synthetase and ligase
S1361_RS37225	COG0477	Major facilitator Superfamily
S1361_RS37235	COG1819	glycosyl
S1361_RS37265	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS37265	COG2319	Wd-40 repeat
S1361_RS37305	COG1397	ADP-ribosylglycohydrolase
S1361_RS37365	COG1819	glycosyl
S1361_RS37390	COG2124	cytochrome p450
S1361_RS37440	COG0644	oxidoreductase
S1361_RS37445	COG2197	response regulator
S1361_RS37450	COG2124	cytochrome p450
S1361_RS37465	COG0717	Belongs to the dCTP deaminase family
S1361_RS37470	COG0717	Belongs to the dCTP deaminase family
S1361_RS37475	COG0297	glycogen (starch) synthase activity
S1361_RS37490	COG0537	adenosine 5'-monophosphoramidase activity
S1361_RS37510	COG1595	DNA-templated transcription, initiation
S1361_RS37540	COG2366	antibiotic biosynthetic process
S1361_RS37560	COG1476	TRANSCRIPTIONal
S1361_RS37565	COG3629	intracellular signal transduction
S1361_RS37565	COG3903	Transcriptional regulator
S1361_RS37575	COG2319	Wd-40 repeat
S1361_RS37575	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS37650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S1361_RS37670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S1361_RS37680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S1361_RS37690	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
S1361_RS37690	COG1672	PFAM Archaeal ATPase
S1361_RS37700	COG3903	Transcriptional regulator
S1361_RS37700	COG3629	intracellular signal transduction
S1361_RS37780	COG0596	Alpha beta hydrolase
S1361_RS37800	COG4249	Peptidase C14 caspase catalytic subunit p20
S1361_RS37800	COG2319	Wd-40 repeat
S1361_RS37840	COG1136	(ABC) transporter
S1361_RS37850	COG4585	Histidine kinase
S1361_RS37855	COG2197	response regulator
S1361_RS38170	COG0419	ATPase involved in DNA repair
S1361_RS38185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1361_RS38205	COG2133	pyrroloquinoline quinone binding
S1361_RS38205	COG5183	chlorophyll binding
S1361_RS38445	COG3209	COG3209 Rhs family protein
S1361_RS38445	COG4104	PAAR repeat-containing protein
S1361_RS38485	COG1864	DNA RNA non-specific endonuclease
S1361_RS38485	COG3591	Belongs to the peptidase S1B family
S1361_RS38550	COG2816	NAD+ diphosphatase activity
S1361_RS38635	COG0420	3'-5' exonuclease activity
S1361_RS38640	COG0419	ATPase involved in DNA repair