locus-tag	class	description
NEH16_RS00015	COG3629	intracellular signal transduction
NEH16_RS00015	COG3903	Transcriptional regulator
NEH16_RS00115	COG3547	Transposase (IS116 IS110 IS902 family)
NEH16_RS00125	COG0640	Transcriptional regulator
NEH16_RS00145	COG0583	DNA-binding transcription factor activity
NEH16_RS00150	COG1280	lysine exporter protein (LysE YggA)
NEH16_RS00280	COG1132	(ABC) transporter
NEH16_RS00455	COG0791	NLP P60 protein
NEH16_RS00540	COG0702	epimerase
NEH16_RS00545	COG1309	transcriptional regulator
NEH16_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS00570	COG0583	DNA-binding transcription factor activity
NEH16_RS00590	COG0596	Alpha beta hydrolase
NEH16_RS00600	COG1609	Transcriptional regulator
NEH16_RS00610	COG1175	transmembrane transport
NEH16_RS00615	COG0395	ABC-type sugar transport system, permease component
NEH16_RS00635	COG1309	transcriptional regulator
NEH16_RS00680	COG0500	methyltransferase
NEH16_RS00685	COG0438	transferase activity, transferring glycosyl groups
NEH16_RS00700	COG0326	Molecular chaperone. Has ATPase activity
NEH16_RS00725	COG4941	Belongs to the sigma-70 factor family
NEH16_RS00730	COG4257	antibiotic catabolic process
NEH16_RS00740	COG1309	transcriptional regulator
NEH16_RS00760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEH16_RS00770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEH16_RS00805	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS00825	COG2208	phosphoserine phosphatase activity
NEH16_RS00825	COG2770	Histidine kinase
NEH16_RS00840	COG0702	epimerase
NEH16_RS00850	COG3655	Transcriptional regulator
NEH16_RS00870	COG2267	carboxylic ester hydrolase activity
NEH16_RS00875	COG1309	transcriptional regulator
NEH16_RS00890	COG2205	protein histidine kinase activity
NEH16_RS00895	COG0745	RESPONSE REGULATOR receiver
NEH16_RS00925	COG1404	Belongs to the peptidase S8 family
NEH16_RS00935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NEH16_RS00940	COG0574	Belongs to the PEP-utilizing enzyme family
NEH16_RS00940	COG3848	Pyruvate phosphate dikinase
NEH16_RS00945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NEH16_RS00990	COG0577	efflux transmembrane transporter activity
NEH16_RS00990	COG1136	(ABC) transporter
NEH16_RS00995	COG4585	Histidine kinase
NEH16_RS01000	COG2197	response regulator
NEH16_RS01040	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NEH16_RS01075	COG0671	phosphoesterase, PA-phosphatase related
NEH16_RS01100	COG2304	oxidoreductase activity
NEH16_RS01130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NEH16_RS01135	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS01160	COG1278	Cold shock
NEH16_RS01170	COG3424	synthase
NEH16_RS01240	COG1357	PFAM Pentapeptide repeats (8 copies)
NEH16_RS01255	COG1024	Enoyl-CoA hydratase
NEH16_RS01280	COG2018	Roadblock/LC7 domain
NEH16_RS01285	COG1316	TRANSCRIPTIONal
NEH16_RS01295	COG2409	Drug exporters of the RND superfamily
NEH16_RS01300	COG1846	Transcriptional regulator
NEH16_RS01330	COG3239	Fatty acid desaturase
NEH16_RS01335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NEH16_RS01355	COG3135	benzoate transporter
NEH16_RS01360	COG1132	(ABC) transporter
NEH16_RS01365	COG4948	Mandelate Racemase Muconate Lactonizing
NEH16_RS01420	COG1132	(ABC) transporter
NEH16_RS01440	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS01445	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS01455	COG3291	Pkd domain containing protein
NEH16_RS01455	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NEH16_RS01465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEH16_RS01475	COG0517	IMP dehydrogenase activity
NEH16_RS01475	COG1125	glycine betaine transport
NEH16_RS01490	COG1174	glycine betaine transport
NEH16_RS01495	COG1174	glycine betaine transport
NEH16_RS01530	COG0142	geranyltranstransferase activity
NEH16_RS01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEH16_RS01610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS01615	COG0601	transmembrane transport
NEH16_RS01635	COG3119	arylsulfatase activity
NEH16_RS01635	COG3408	Glycogen debranching enzyme
NEH16_RS01650	COG0488	(ABC) transporter
NEH16_RS01655	COG0488	(ABC) transporter
NEH16_RS01660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NEH16_RS01665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NEH16_RS01670	COG2080	2 iron, 2 sulfur cluster binding
NEH16_RS01695	COG5002	protein histidine kinase activity
NEH16_RS01700	COG0745	RESPONSE REGULATOR receiver
NEH16_RS01755	COG0028	Belongs to the TPP enzyme family
NEH16_RS01790	COG1335	isochorismatase
NEH16_RS01795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NEH16_RS01810	COG2124	cytochrome p450
NEH16_RS01815	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS01820	COG1982	Orn Lys Arg decarboxylase major
NEH16_RS01825	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NEH16_RS01845	COG0693	protein deglycase activity
NEH16_RS01860	COG0531	amino acid
NEH16_RS01885	COG0243	molybdopterin cofactor binding
NEH16_RS01920	COG0859	PFAM glycosyl transferase family 9
NEH16_RS01930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NEH16_RS01935	COG0297	glycogen (starch) synthase activity
NEH16_RS01945	COG0859	PFAM glycosyl transferase family 9
NEH16_RS01950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NEH16_RS01960	COG2192	nodulation
NEH16_RS01965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEH16_RS02010	COG1621	beta-fructofuranosidase activity
NEH16_RS02010	COG3583	domain protein
NEH16_RS02010	COG5492	domain, Protein
NEH16_RS02025	COG2124	cytochrome p450
NEH16_RS02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NEH16_RS02055	COG1132	(ABC) transporter
NEH16_RS02075	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS02085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEH16_RS02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEH16_RS02110	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS02135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NEH16_RS02145	COG1522	sequence-specific DNA binding
NEH16_RS02170	COG3511	phospholipase C
NEH16_RS02180	COG1428	Deoxynucleoside kinase
NEH16_RS02240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS02245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NEH16_RS02255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NEH16_RS02260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NEH16_RS02265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NEH16_RS02270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NEH16_RS02275	COG0254	rRNA binding
NEH16_RS02285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NEH16_RS02315	COG1121	(ABC) transporter
NEH16_RS02320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NEH16_RS02325	COG3764	Sortase (surface protein transpeptidase)
NEH16_RS02375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEH16_RS02380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NEH16_RS02405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NEH16_RS02410	COG0121	glutamine amidotransferase
NEH16_RS02415	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NEH16_RS02420	COG2182	Extracellular solute-binding protein
NEH16_RS02440	COG3979	chitinase
NEH16_RS02445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NEH16_RS02450	COG1053	succinate dehydrogenase
NEH16_RS02520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEH16_RS02535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NEH16_RS02580	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NEH16_RS02600	COG0829	nickel cation binding
NEH16_RS02605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NEH16_RS02610	COG0830	nickel cation binding
NEH16_RS02615	COG0804	urea catabolic process
NEH16_RS02620	COG0832	Belongs to the urease beta subunit family
NEH16_RS02625	COG0831	urea catabolic process
NEH16_RS02645	COG1191	sigma factor activity
NEH16_RS02655	COG4251	negative regulation of phosphorylation
NEH16_RS02660	COG0784	Response regulator, receiver
NEH16_RS02685	COG3537	Alpha-1,2-mannosidase
NEH16_RS02720	COG1175	transmembrane transport
NEH16_RS02735	COG0789	Transcriptional regulator
NEH16_RS02765	COG1285	pathogenesis
NEH16_RS02800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NEH16_RS02805	COG2910	NAD(P)H-binding
NEH16_RS02820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NEH16_RS02835	COG3845	ABC transporter
NEH16_RS02880	COG0753	catalase activity
NEH16_RS02905	COG1295	ribonuclease BN
NEH16_RS02920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEH16_RS02920	COG0493	'glutamate synthase
NEH16_RS02930	COG1902	pentaerythritol trinitrate reductase activity
NEH16_RS02930	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEH16_RS02965	COG1051	belongs to the nudix hydrolase family
NEH16_RS02975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NEH16_RS03015	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEH16_RS03015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NEH16_RS03025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NEH16_RS03045	COG1556	Lactate utilization protein
NEH16_RS03050	COG1139	Iron-sulfur cluster binding protein
NEH16_RS03055	COG0247	lactate metabolic process
NEH16_RS03065	COG1619	proteins homologs of microcin C7 resistance protein MccF
NEH16_RS03090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NEH16_RS03100	COG0673	inositol 2-dehydrogenase activity
NEH16_RS03105	COG2188	Transcriptional regulator
NEH16_RS03120	COG0395	ABC-type sugar transport system, permease component
NEH16_RS03145	COG0604	alcohol dehydrogenase
NEH16_RS03145	COG3321	synthase
NEH16_RS03170	COG0395	ABC-type sugar transport system, permease component
NEH16_RS03175	COG4209	transmembrane transport
NEH16_RS03185	COG1609	Transcriptional regulator
NEH16_RS03245	COG3467	pyridoxamine 5'-phosphate
NEH16_RS03300	COG2755	lipolytic protein G-D-S-L family
NEH16_RS03310	COG2365	Tyrosine phosphatase family
NEH16_RS03330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NEH16_RS03340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NEH16_RS03345	COG1657	PFAM Prenyltransferase squalene oxidase
NEH16_RS03355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NEH16_RS03370	COG1388	LysM domain
NEH16_RS03370	COG1134	teichoic acid transport
NEH16_RS03420	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NEH16_RS03435	COG1024	Enoyl-CoA hydratase
NEH16_RS03445	COG4977	sequence-specific DNA binding
NEH16_RS03455	COG2183	response to ionizing radiation
NEH16_RS03470	COG0488	(ABC) transporter
NEH16_RS03480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NEH16_RS03490	COG0789	Transcriptional regulator
NEH16_RS03495	COG2814	Major facilitator Superfamily
NEH16_RS03500	COG2267	carboxylic ester hydrolase activity
NEH16_RS03525	COG0789	Transcriptional regulator
NEH16_RS03530	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEH16_RS03530	COG1024	Enoyl-CoA hydratase
NEH16_RS03535	COG0183	Belongs to the thiolase family
NEH16_RS03540	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS03545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NEH16_RS03550	COG3268	Saccharopine dehydrogenase
NEH16_RS03555	COG1515	deoxyribonuclease V activity
NEH16_RS03570	COG0488	(ABC) transporter
NEH16_RS03610	COG3285	dna ligase
NEH16_RS03610	COG1793	dna ligase
NEH16_RS03615	COG1793	dna ligase
NEH16_RS03650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NEH16_RS03675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NEH16_RS03720	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS03770	COG1486	melibiose metabolic process
NEH16_RS03800	COG1846	Transcriptional regulator
NEH16_RS03830	COG1940	carbohydrate kinase activity
NEH16_RS03865	COG1501	Belongs to the glycosyl hydrolase 31 family
NEH16_RS03870	COG1472	Belongs to the glycosyl hydrolase 3 family
NEH16_RS03880	COG4209	transmembrane transport
NEH16_RS03885	COG0395	ABC-type sugar transport system, permease component
NEH16_RS03920	COG3511	phospholipase C
NEH16_RS03925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NEH16_RS03930	COG0464	growth
NEH16_RS03935	COG0745	RESPONSE REGULATOR receiver
NEH16_RS03940	COG5002	protein histidine kinase activity
NEH16_RS03980	COG1879	ABC-type sugar transport system periplasmic component
NEH16_RS03985	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS03990	COG1129	ABC transporter
NEH16_RS03995	COG1940	carbohydrate kinase activity
NEH16_RS03995	COG1846	Transcriptional regulator
NEH16_RS04000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEH16_RS04005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NEH16_RS04015	COG0583	DNA-binding transcription factor activity
NEH16_RS04025	COG0656	L-ascorbic acid biosynthetic process
NEH16_RS04030	COG4106	trans-aconitate 2-methyltransferase activity
NEH16_RS04040	COG0583	DNA-binding transcription factor activity
NEH16_RS04045	COG2154	pterin-4-alpha-carbinolamine dehydratase
NEH16_RS04055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NEH16_RS04055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NEH16_RS04070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NEH16_RS04100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NEH16_RS04125	COG2226	methyltransferase
NEH16_RS04135	COG1660	Displays ATPase and GTPase activities
NEH16_RS04150	COG3959	Transketolase, thiamine diphosphate binding domain
NEH16_RS04165	COG1619	proteins homologs of microcin C7 resistance protein MccF
NEH16_RS04175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEH16_RS04180	COG2362	D-Aminopeptidase
NEH16_RS04185	COG0667	Aldo Keto reductase
NEH16_RS04190	COG0583	DNA-binding transcription factor activity
NEH16_RS04200	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS04200	COG2208	phosphoserine phosphatase activity
NEH16_RS04200	COG2172	sigma factor antagonist activity
NEH16_RS04230	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEH16_RS04245	COG0604	alcohol dehydrogenase
NEH16_RS04250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEH16_RS04250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEH16_RS04255	COG2301	Belongs to the HpcH HpaI aldolase family
NEH16_RS04265	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS04270	COG0688	phosphatidylethanolamine metabolic process
NEH16_RS04285	COG3507	Belongs to the glycosyl hydrolase 43 family
NEH16_RS04330	COG0559	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS04335	COG0559	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS04350	COG1929	Belongs to the glycerate kinase type-1 family
NEH16_RS04365	COG2226	methyltransferase
NEH16_RS04375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NEH16_RS04395	COG2175	clavaminate synthase activity
NEH16_RS04415	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS04420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NEH16_RS04425	COG3119	arylsulfatase activity
NEH16_RS04440	COG4412	M6 family metalloprotease domain protein
NEH16_RS04440	COG1404	Belongs to the peptidase S8 family
NEH16_RS04465	COG0483	inositol monophosphate 1-phosphatase activity
NEH16_RS04500	COG0095	Lipoate-protein ligase
NEH16_RS04520	COG1953	Uracil, thiamine, allantoin
NEH16_RS04530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NEH16_RS04570	COG0405	Gamma-glutamyltransferase
NEH16_RS04600	COG2205	protein histidine kinase activity
NEH16_RS04605	COG0745	RESPONSE REGULATOR receiver
NEH16_RS04625	COG0765	amino acid transport
NEH16_RS04630	COG0765	amino acid transport
NEH16_RS04635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEH16_RS04640	COG1126	abc transporter atp-binding protein
NEH16_RS04655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NEH16_RS04660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEH16_RS04675	COG1408	metallophosphoesterase
NEH16_RS04685	COG1414	Transcriptional regulator
NEH16_RS04700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEH16_RS04730	COG0747	negative chemotaxis
NEH16_RS04735	COG1309	transcriptional regulator
NEH16_RS04755	COG2723	6-phospho-beta-galactosidase activity
NEH16_RS04765	COG0640	Transcriptional regulator
NEH16_RS04780	COG1940	carbohydrate kinase activity
NEH16_RS04785	COG1129	ABC transporter
NEH16_RS04805	COG2197	response regulator
NEH16_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS04835	COG4266	Belongs to the allantoicase family
NEH16_RS04840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NEH16_RS04845	COG1414	Transcriptional regulator
NEH16_RS04855	COG0746	molybdenum cofactor guanylyltransferase activity
NEH16_RS04860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NEH16_RS04905	COG3864	Putative metallopeptidase domain
NEH16_RS04925	COG2267	carboxylic ester hydrolase activity
NEH16_RS04940	COG2233	PERMEase
NEH16_RS04950	COG2233	PERMEase
NEH16_RS04980	COG2706	6-phosphogluconolactonase activity
NEH16_RS04985	COG2188	Transcriptional regulator
NEH16_RS04995	COG1175	transmembrane transport
NEH16_RS05000	COG0395	ABC-type sugar transport system, permease component
NEH16_RS05015	COG3622	Belongs to the hyi family
NEH16_RS05020	COG2084	Dehydrogenase
NEH16_RS05025	COG0753	catalase activity
NEH16_RS05100	COG3960	tartronate-semialdehyde synthase activity
NEH16_RS05115	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS05120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEH16_RS05125	COG2197	response regulator
NEH16_RS05160	COG0667	Aldo Keto reductase
NEH16_RS05170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS05175	COG1116	anion transmembrane transporter activity
NEH16_RS05225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NEH16_RS05240	COG1404	Belongs to the peptidase S8 family
NEH16_RS05245	COG3608	succinylglutamate desuccinylase aspartoacylase
NEH16_RS05245	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NEH16_RS05250	COG2252	PERMEase
NEH16_RS05345	COG1162	GTPase activity
NEH16_RS05395	COG0183	Belongs to the thiolase family
NEH16_RS05400	COG0583	DNA-binding transcription factor activity
NEH16_RS05405	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEH16_RS05430	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS05455	COG0175	sulfate reduction
NEH16_RS05460	COG0529	Catalyzes the synthesis of activated sulfate
NEH16_RS05480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NEH16_RS05485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NEH16_RS05495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NEH16_RS05505	COG1119	ATPase activity
NEH16_RS05520	COG2409	Drug exporters of the RND superfamily
NEH16_RS05595	COG0346	lactoylglutathione lyase activity
NEH16_RS05600	COG0583	DNA-binding transcription factor activity
NEH16_RS05605	COG0156	8-amino-7-oxononanoate synthase activity
NEH16_RS05610	COG1063	alcohol dehydrogenase
NEH16_RS05620	COG0009	L-threonylcarbamoyladenylate synthase
NEH16_RS05655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEH16_RS05665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEH16_RS05670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NEH16_RS05765	COG3220	belongs to the UPF0276 family
NEH16_RS05780	COG3253	May function as heme-dependent peroxidase
NEH16_RS05785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NEH16_RS05795	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEH16_RS05800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NEH16_RS05820	COG0183	Belongs to the thiolase family
NEH16_RS05825	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEH16_RS05825	COG1024	Enoyl-CoA hydratase
NEH16_RS05840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NEH16_RS05840	COG1215	transferase activity, transferring glycosyl groups
NEH16_RS05870	COG0531	amino acid
NEH16_RS05875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NEH16_RS05880	COG4214	carbohydrate transport
NEH16_RS05890	COG4213	ABC transporter substrate-binding protein
NEH16_RS05900	COG0395	ABC-type sugar transport system, permease component
NEH16_RS05905	COG1175	transmembrane transport
NEH16_RS05910	COG1653	transport
NEH16_RS05925	COG1501	Belongs to the glycosyl hydrolase 31 family
NEH16_RS05935	COG1175	transmembrane transport
NEH16_RS05940	COG0395	ABC-type sugar transport system, permease component
NEH16_RS05965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NEH16_RS05980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NEH16_RS05985	COG0076	glutamate decarboxylase activity
NEH16_RS05990	COG1794	racemase activity, acting on amino acids and derivatives
NEH16_RS06025	COG0601	transmembrane transport
NEH16_RS06030	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS06055	COG4948	Mandelate Racemase Muconate Lactonizing
NEH16_RS06065	COG3046	protein related to deoxyribodipyrimidine photolyase
NEH16_RS06075	COG1595	DNA-templated transcription, initiation
NEH16_RS06100	COG3119	arylsulfatase activity
NEH16_RS06110	COG0395	ABC-type sugar transport system, permease component
NEH16_RS06115	COG1175	transmembrane transport
NEH16_RS06150	COG3979	chitinase
NEH16_RS06180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NEH16_RS06200	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NEH16_RS06215	COG0725	ABC transporter, periplasmic molybdate-binding protein
NEH16_RS06225	COG0243	molybdopterin cofactor binding
NEH16_RS06230	COG1320	monovalent cation:proton antiporter activity
NEH16_RS06250	COG1006	Multisubunit Na H antiporter MnhC subunit
NEH16_RS06280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEH16_RS06315	COG1024	Enoyl-CoA hydratase
NEH16_RS06325	COG0531	amino acid
NEH16_RS06330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NEH16_RS06340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NEH16_RS06350	COG2040	homocysteine
NEH16_RS06370	COG1799	cell septum assembly
NEH16_RS06405	COG0673	inositol 2-dehydrogenase activity
NEH16_RS06415	COG0395	ABC-type sugar transport system, permease component
NEH16_RS06420	COG4209	transmembrane transport
NEH16_RS06425	COG1349	DNA-binding transcription factor activity
NEH16_RS06430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NEH16_RS06445	COG0586	Pfam SNARE associated Golgi protein
NEH16_RS06450	COG4585	Histidine kinase
NEH16_RS06465	COG1309	transcriptional regulator
NEH16_RS06475	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NEH16_RS06505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NEH16_RS06540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEH16_RS06585	COG2890	protein-(glutamine-N5) methyltransferase activity
NEH16_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS06610	COG1937	Protein conserved in bacteria
NEH16_RS06620	COG0596	Alpha beta hydrolase
NEH16_RS06620	COG2945	thiolester hydrolase activity
NEH16_RS06625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NEH16_RS06635	COG1404	Belongs to the peptidase S8 family
NEH16_RS06635	COG4412	M6 family metalloprotease domain protein
NEH16_RS06650	COG1174	glycine betaine transport
NEH16_RS06660	COG1174	glycine betaine transport
NEH16_RS06670	COG1732	Glycine betaine
NEH16_RS06685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NEH16_RS06690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NEH16_RS06695	COG0440	acetolactate synthase activity
NEH16_RS06725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NEH16_RS06735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NEH16_RS06745	COG0069	glutamate synthase activity
NEH16_RS06775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NEH16_RS06785	COG3629	intracellular signal transduction
NEH16_RS06785	COG3903	Transcriptional regulator
NEH16_RS06800	COG2814	Major facilitator Superfamily
NEH16_RS06835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NEH16_RS06870	COG0395	ABC-type sugar transport system, permease component
NEH16_RS06900	COG2273	Hydrolase Family 16
NEH16_RS06905	COG3654	unkown
NEH16_RS06920	COG0525	valine-tRNA ligase activity
NEH16_RS06925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEH16_RS06940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEH16_RS06985	COG0297	glycogen (starch) synthase activity
NEH16_RS07035	COG4974	Belongs to the 'phage' integrase family
NEH16_RS07060	COG1104	cysteine desulfurase activity
NEH16_RS07075	COG0482	sulfurtransferase activity
NEH16_RS07130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NEH16_RS07135	COG0531	amino acid
NEH16_RS07140	COG0569	domain protein
NEH16_RS07170	COG1136	(ABC) transporter
NEH16_RS07170	COG4591	ABC-type transport system involved in lipoprotein release permease component
NEH16_RS07175	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NEH16_RS07200	COG0756	dUTP diphosphatase activity
NEH16_RS07230	COG0745	RESPONSE REGULATOR receiver
NEH16_RS07245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NEH16_RS07285	COG1435	thymidine kinase activity
NEH16_RS07300	COG0045	succinate-CoA ligase (ADP-forming) activity
NEH16_RS07300	COG1042	CoA-binding domain protein
NEH16_RS07300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEH16_RS07305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEH16_RS07310	COG1802	Transcriptional regulator
NEH16_RS07325	COG0612	Peptidase, M16
NEH16_RS07330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NEH16_RS07340	COG0372	Belongs to the citrate synthase family
NEH16_RS07345	COG0372	Belongs to the citrate synthase family
NEH16_RS07365	COG2197	response regulator
NEH16_RS07370	COG4585	Histidine kinase
NEH16_RS07400	COG2186	Transcriptional regulator
NEH16_RS07435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NEH16_RS07450	COG0588	phosphoglycerate mutase activity
NEH16_RS07465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEH16_RS07470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NEH16_RS07475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NEH16_RS07515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NEH16_RS07530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NEH16_RS07540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NEH16_RS07555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NEH16_RS07560	COG2358	TRAP transporter, solute receptor (TAXI family
NEH16_RS07565	COG0642	Histidine kinase
NEH16_RS07570	COG0745	RESPONSE REGULATOR receiver
NEH16_RS07575	COG1126	abc transporter atp-binding protein
NEH16_RS07580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEH16_RS07585	COG0765	amino acid transport
NEH16_RS07590	COG0765	amino acid transport
NEH16_RS07630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NEH16_RS07670	COG1201	RNA secondary structure unwinding
NEH16_RS07675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NEH16_RS07690	COG0582	viral genome integration into host DNA
NEH16_RS07980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEH16_RS07990	COG3620	sequence-specific DNA binding
NEH16_RS07995	COG0783	Belongs to the Dps family
NEH16_RS08000	COG1396	sequence-specific DNA binding
NEH16_RS08015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NEH16_RS08025	COG1674	ftsk spoiiie
NEH16_RS08035	COG3850	Histidine kinase
NEH16_RS08035	COG3437	response regulator, receiver
NEH16_RS08035	COG4999	Histidine kinase
NEH16_RS08035	COG2205	protein histidine kinase activity
NEH16_RS08070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NEH16_RS08075	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NEH16_RS08095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NEH16_RS08100	COG0612	Peptidase, M16
NEH16_RS08105	COG1185	polyribonucleotide nucleotidyltransferase activity
NEH16_RS08110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NEH16_RS08120	COG1674	ftsk spoiiie
NEH16_RS08140	COG1404	Belongs to the peptidase S8 family
NEH16_RS08145	COG3266	domain, Protein
NEH16_RS08165	COG0747	negative chemotaxis
NEH16_RS08170	COG0601	transmembrane transport
NEH16_RS08175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS08180	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS08200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NEH16_RS08205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NEH16_RS08215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NEH16_RS08230	COG0779	Required for maturation of 30S ribosomal subunits
NEH16_RS08250	COG0442	prolyl-tRNA aminoacylation
NEH16_RS08270	COG0750	zinc metalloprotease
NEH16_RS08275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NEH16_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS08340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NEH16_RS08350	COG4585	Histidine kinase
NEH16_RS08355	COG2197	response regulator
NEH16_RS08370	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS08375	COG1136	(ABC) transporter
NEH16_RS08390	COG3842	ATPase activity
NEH16_RS08405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NEH16_RS08415	COG0575	Belongs to the CDS family
NEH16_RS08420	COG0233	cytoplasmic translational termination
NEH16_RS08425	COG0528	UMP kinase activity
NEH16_RS08430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NEH16_RS08435	COG0052	Belongs to the universal ribosomal protein uS2 family
NEH16_RS08450	COG1191	sigma factor activity
NEH16_RS08480	COG0681	Belongs to the peptidase S26 family
NEH16_RS08485	COG0681	Belongs to the peptidase S26 family
NEH16_RS08495	COG0681	Belongs to the peptidase S26 family
NEH16_RS08500	COG0681	Belongs to the peptidase S26 family
NEH16_RS08505	COG0335	large ribosomal subunit rRNA binding
NEH16_RS08510	COG0336	Belongs to the RNA methyltransferase TrmD family
NEH16_RS08515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NEH16_RS08520	COG1837	Belongs to the UPF0109 family
NEH16_RS08525	COG0228	four-way junction DNA binding
NEH16_RS08545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NEH16_RS08575	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NEH16_RS08580	COG0477	Major facilitator Superfamily
NEH16_RS08585	COG1196	nuclear chromosome segregation
NEH16_RS08595	COG1254	Belongs to the acylphosphatase family
NEH16_RS08600	COG2340	Cysteine-rich secretory protein family
NEH16_RS08605	COG1733	regulation of RNA biosynthetic process
NEH16_RS08610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NEH16_RS08615	COG0571	ribonuclease III activity
NEH16_RS08620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NEH16_RS08635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NEH16_RS08640	COG0742	ribosomal rna small subunit methyltransferase
NEH16_RS08650	COG1461	Dihydroxyacetone kinase
NEH16_RS08655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NEH16_RS08685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NEH16_RS08695	COG1920	GTP binding
NEH16_RS08720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NEH16_RS08725	COG1414	Transcriptional regulator
NEH16_RS08735	COG0789	Transcriptional regulator
NEH16_RS08765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NEH16_RS08770	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEH16_RS08785	COG2018	Roadblock/LC7 domain
NEH16_RS08805	COG2018	Roadblock/LC7 domain
NEH16_RS08825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEH16_RS08830	COG1653	transport
NEH16_RS08875	COG2353	YceI-like domain
NEH16_RS08880	COG2318	DinB family
NEH16_RS08950	COG2723	6-phospho-beta-galactosidase activity
NEH16_RS08955	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS08960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS08965	COG0601	transmembrane transport
NEH16_RS08975	COG4166	transmembrane transport
NEH16_RS08985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEH16_RS08990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NEH16_RS08995	COG0473	3-isopropylmalate dehydrogenase activity
NEH16_RS09030	COG0506	proline dehydrogenase activity
NEH16_RS09045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NEH16_RS09050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NEH16_RS09055	COG0440	acetolactate synthase activity
NEH16_RS09075	COG0667	Aldo Keto reductase
NEH16_RS09085	COG2197	response regulator
NEH16_RS09100	COG2409	Drug exporters of the RND superfamily
NEH16_RS09110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NEH16_RS09120	COG0154	amidase activity
NEH16_RS09125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NEH16_RS09135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NEH16_RS09145	COG4221	oxidoreductase activity
NEH16_RS09155	COG0482	sulfurtransferase activity
NEH16_RS09190	COG2860	membrane
NEH16_RS09195	COG4608	Belongs to the ABC transporter superfamily
NEH16_RS09200	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS09235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NEH16_RS09240	COG0509	glycine decarboxylation via glycine cleavage system
NEH16_RS09245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NEH16_RS09250	COG1760	l-serine dehydratase
NEH16_RS09255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEH16_RS09285	COG1376	ErfK ybiS ycfS ynhG family protein
NEH16_RS09295	COG2197	response regulator
NEH16_RS09300	COG4585	Histidine kinase
NEH16_RS09310	COG1131	(ABC) transporter
NEH16_RS09315	COG1132	(ABC) transporter
NEH16_RS09320	COG1132	(ABC) transporter
NEH16_RS09335	COG0058	SHG alpha-glucan phosphorylase activity
NEH16_RS09345	COG0366	Alpha amylase catalytic
NEH16_RS09355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NEH16_RS09360	COG3118	belongs to the thioredoxin family
NEH16_RS09370	COG1301	dicarboxylic acid transport
NEH16_RS09375	COG3290	protein histidine kinase activity
NEH16_RS09380	COG4565	transcriptional regulatory protein
NEH16_RS09390	COG0205	6-phosphofructokinase activity
NEH16_RS09395	COG0280	phosphate acetyltransferase
NEH16_RS09395	COG0857	belongs to the CobB CobQ family
NEH16_RS09400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NEH16_RS09435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEH16_RS09435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEH16_RS09485	COG0745	RESPONSE REGULATOR receiver
NEH16_RS09520	COG1131	(ABC) transporter
NEH16_RS09555	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NEH16_RS09570	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEH16_RS09600	COG3850	Histidine kinase
NEH16_RS09605	COG2197	response regulator
NEH16_RS09620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NEH16_RS09625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NEH16_RS09630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NEH16_RS09635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NEH16_RS09640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NEH16_RS09645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NEH16_RS09650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NEH16_RS09670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NEH16_RS09680	COG2890	protein-(glutamine-N5) methyltransferase activity
NEH16_RS09685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NEH16_RS09690	COG0254	rRNA binding
NEH16_RS09695	COG1316	TRANSCRIPTIONal
NEH16_RS09705	COG0083	homoserine kinase activity
NEH16_RS09710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NEH16_RS09720	COG0019	diaminopimelate decarboxylase activity
NEH16_RS09730	COG0745	RESPONSE REGULATOR receiver
NEH16_RS09775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NEH16_RS09785	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NEH16_RS09790	COG1793	dna ligase
NEH16_RS09790	COG3285	dna ligase
NEH16_RS09810	COG2205	protein histidine kinase activity
NEH16_RS09820	COG0768	penicillin binding
NEH16_RS09870	COG0791	NLP P60 protein
NEH16_RS09870	COG3883	PFAM NLP P60 protein
NEH16_RS09915	COG0726	polysaccharide deacetylase
NEH16_RS09920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NEH16_RS09925	COG2226	methyltransferase
NEH16_RS09945	COG0745	RESPONSE REGULATOR receiver
NEH16_RS09950	COG2205	protein histidine kinase activity
NEH16_RS09955	COG0567	Dehydrogenase, E1 component
NEH16_RS09955	COG0508	dehydrogenase complex catalyzes the overall conversion of
NEH16_RS10045	COG0542	response to heat
NEH16_RS10055	COG0604	alcohol dehydrogenase
NEH16_RS10060	COG0281	malic enzyme
NEH16_RS10075	COG1126	abc transporter atp-binding protein
NEH16_RS10085	COG1595	DNA-templated transcription, initiation
NEH16_RS10135	COG0702	epimerase
NEH16_RS10155	COG5640	endopeptidase activity
NEH16_RS10175	COG0142	geranyltranstransferase activity
NEH16_RS10180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEH16_RS10185	COG1959	2 iron, 2 sulfur cluster binding
NEH16_RS10190	COG1017	nitric oxide dioxygenase activity
NEH16_RS10190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEH16_RS10215	COG2172	sigma factor antagonist activity
NEH16_RS10230	COG1597	lipid kinase activity
NEH16_RS10245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NEH16_RS10250	COG0363	glucosamine-6-phosphate deaminase activity
NEH16_RS10255	COG1472	Belongs to the glycosyl hydrolase 3 family
NEH16_RS10260	COG0395	ABC-type sugar transport system, permease component
NEH16_RS10265	COG1175	transmembrane transport
NEH16_RS10270	COG2182	Extracellular solute-binding protein
NEH16_RS10320	COG0242	peptide deformylase activity
NEH16_RS10340	COG5662	AntiSigma factor
NEH16_RS10345	COG1595	DNA-templated transcription, initiation
NEH16_RS10355	COG2135	peptidase activity
NEH16_RS10365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NEH16_RS10370	COG1162	GTPase activity
NEH16_RS10375	COG2076	Multidrug Resistance protein
NEH16_RS10380	COG0483	inositol monophosphate 1-phosphatase activity
NEH16_RS10390	COG0753	catalase activity
NEH16_RS10415	COG1615	UPF0182 protein
NEH16_RS10425	COG3480	Lon protease (S16) C-terminal proteolytic domain
NEH16_RS10480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NEH16_RS10520	COG0210	DNA helicase
NEH16_RS10620	COG1432	Conserved Protein
NEH16_RS10630	COG2095	MarC family integral membrane protein
NEH16_RS10645	COG2814	Major facilitator Superfamily
NEH16_RS10670	COG0516	GMP reductase activity
NEH16_RS10670	COG0517	IMP dehydrogenase activity
NEH16_RS10690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEH16_RS10695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEH16_RS10705	COG1595	DNA-templated transcription, initiation
NEH16_RS10720	COG1024	Enoyl-CoA hydratase
NEH16_RS10725	COG0519	Catalyzes the synthesis of GMP from XMP
NEH16_RS10735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NEH16_RS10740	COG1611	Belongs to the LOG family
NEH16_RS10745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEH16_RS10790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NEH16_RS10795	COG0738	Major facilitator superfamily
NEH16_RS10805	COG3226	Transcriptional regulator
NEH16_RS10810	COG2226	methyltransferase
NEH16_RS10835	COG1131	(ABC) transporter
NEH16_RS10845	COG2197	response regulator
NEH16_RS10850	COG2197	response regulator
NEH16_RS10855	COG4585	Histidine kinase
NEH16_RS10865	COG1131	(ABC) transporter
NEH16_RS10880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NEH16_RS10900	COG4608	Belongs to the ABC transporter superfamily
NEH16_RS10905	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS10910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS10915	COG0601	transmembrane transport
NEH16_RS10920	COG4166	transmembrane transport
NEH16_RS10925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS10930	COG0747	negative chemotaxis
NEH16_RS10935	COG0601	transmembrane transport
NEH16_RS10940	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS10945	COG4608	Belongs to the ABC transporter superfamily
NEH16_RS10950	COG4608	Belongs to the ABC transporter superfamily
NEH16_RS10955	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS10960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS10970	COG4166	transmembrane transport
NEH16_RS10975	COG1217	gtp-binding protein TYPA
NEH16_RS10990	COG1335	isochorismatase
NEH16_RS10995	COG0477	Major facilitator Superfamily
NEH16_RS11015	COG1842	Phage shock protein A
NEH16_RS11055	COG4221	oxidoreductase activity
NEH16_RS11060	COG1309	transcriptional regulator
NEH16_RS11090	COG0012	GTP binding
NEH16_RS11110	COG4607	ABC-type enterochelin transport system periplasmic component
NEH16_RS11115	COG1120	ATPase activity
NEH16_RS11120	COG2207	Transcriptional regulator
NEH16_RS11140	COG0531	amino acid
NEH16_RS11145	COG1570	exodeoxyribonuclease VII activity
NEH16_RS11150	COG1722	exodeoxyribonuclease VII activity
NEH16_RS11155	COG0778	Nitroreductase
NEH16_RS11180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NEH16_RS11180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NEH16_RS11195	COG1362	aminopeptidase activity
NEH16_RS11205	COG0114	fumarate hydratase activity
NEH16_RS11240	COG1136	(ABC) transporter
NEH16_RS11255	COG0450	alkyl hydroperoxide reductase
NEH16_RS11260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEH16_RS11275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NEH16_RS11280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NEH16_RS11285	COG0667	Aldo Keto reductase
NEH16_RS11335	COG2318	DinB family
NEH16_RS11340	COG1959	2 iron, 2 sulfur cluster binding
NEH16_RS11340	COG1295	ribonuclease BN
NEH16_RS11360	COG2885	chlorophyll binding
NEH16_RS11425	COG0515	serine threonine protein kinase
NEH16_RS11425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEH16_RS11435	COG2610	gluconate transmembrane transporter activity
NEH16_RS11440	COG0251	oxidation-reduction process
NEH16_RS11445	COG1414	Transcriptional regulator
NEH16_RS11460	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NEH16_RS11500	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NEH16_RS11510	COG1331	Highly conserved protein containing a thioredoxin domain
NEH16_RS11525	COG2205	protein histidine kinase activity
NEH16_RS11530	COG0745	RESPONSE REGULATOR receiver
NEH16_RS11535	COG2255	four-way junction helicase activity
NEH16_RS11545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NEH16_RS11555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NEH16_RS11570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEH16_RS11605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEH16_RS11610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NEH16_RS11620	COG1136	(ABC) transporter
NEH16_RS11630	COG1376	ErfK ybiS ycfS ynhG family protein
NEH16_RS11650	COG1024	Enoyl-CoA hydratase
NEH16_RS11665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEH16_RS11675	COG0424	maF-like protein
NEH16_RS11685	COG4770	biotin carboxylase activity
NEH16_RS11715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NEH16_RS11730	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS11735	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS11750	COG1595	DNA-templated transcription, initiation
NEH16_RS11755	COG0745	RESPONSE REGULATOR receiver
NEH16_RS11760	COG2205	protein histidine kinase activity
NEH16_RS11785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NEH16_RS11795	COG0583	DNA-binding transcription factor activity
NEH16_RS11800	COG2814	Major facilitator Superfamily
NEH16_RS11835	COG2801	Transposase and inactivated derivatives
NEH16_RS11870	COG1079	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS11875	COG4603	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS11885	COG1744	ABC transporter substrate-binding protein PnrA-like
NEH16_RS11890	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NEH16_RS11890	COG1473	amidohydrolase
NEH16_RS11900	COG2089	acid synthase
NEH16_RS11905	COG1083	cytidylyl-transferase
NEH16_RS11915	COG1216	Glycosyl transferase, family 2
NEH16_RS11950	COG1595	DNA-templated transcription, initiation
NEH16_RS11965	COG3583	domain protein
NEH16_RS11965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NEH16_RS11965	COG3064	Membrane
NEH16_RS11975	COG2009	succinate dehydrogenase
NEH16_RS11985	COG1053	succinate dehydrogenase
NEH16_RS11990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NEH16_RS12020	COG1408	metallophosphoesterase
NEH16_RS12035	COG1295	ribonuclease BN
NEH16_RS12055	COG0180	Tryptophanyl-tRNA synthetase
NEH16_RS12060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NEH16_RS12070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEH16_RS12080	COG0039	L-malate dehydrogenase activity
NEH16_RS12090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NEH16_RS12100	COG0138	bifunctional purine biosynthesis protein purh
NEH16_RS12130	COG0045	succinate-CoA ligase (ADP-forming) activity
NEH16_RS12135	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NEH16_RS12140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NEH16_RS12145	COG0714	Associated with various cellular activities
NEH16_RS12160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEH16_RS12170	COG0739	heme binding
NEH16_RS12200	COG2197	response regulator
NEH16_RS12230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NEH16_RS12235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NEH16_RS12235	COG0519	Catalyzes the synthesis of GMP from XMP
NEH16_RS12255	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS12260	COG0515	serine threonine protein kinase
NEH16_RS12275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NEH16_RS12290	COG0516	GMP reductase activity
NEH16_RS12300	COG1595	DNA-templated transcription, initiation
NEH16_RS12315	COG0583	DNA-binding transcription factor activity
NEH16_RS12325	COG4221	oxidoreductase activity
NEH16_RS12335	COG1609	Transcriptional regulator
NEH16_RS12360	COG0640	Transcriptional regulator
NEH16_RS12390	COG0726	polysaccharide deacetylase
NEH16_RS12410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NEH16_RS12430	COG0802	atpase or kinase
NEH16_RS12445	COG3189	MarR family transcriptional regulator
NEH16_RS12460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NEH16_RS12465	COG0477	Major facilitator Superfamily
NEH16_RS12485	COG0583	DNA-binding transcription factor activity
NEH16_RS12510	COG0137	argininosuccinate synthase activity
NEH16_RS12525	COG1072	(Pantothenic acid kinase))
NEH16_RS12535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NEH16_RS12540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NEH16_RS12545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NEH16_RS12560	COG0101	tRNA pseudouridine synthase activity
NEH16_RS12565	COG0203	ribosomal protein L17
NEH16_RS12570	COG0202	RNA polymerase activity
NEH16_RS12575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NEH16_RS12580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NEH16_RS12585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NEH16_RS12590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NEH16_RS12600	COG0563	adenylate kinase activity
NEH16_RS12610	COG0200	Binds to the 23S rRNA
NEH16_RS12615	COG1841	ribosomal large subunit assembly
NEH16_RS12620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NEH16_RS12625	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NEH16_RS12630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NEH16_RS12635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NEH16_RS12640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NEH16_RS12645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NEH16_RS12650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NEH16_RS12655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NEH16_RS12660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NEH16_RS12665	COG0255	Belongs to the universal ribosomal protein uL29 family
NEH16_RS12670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NEH16_RS12675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NEH16_RS12680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NEH16_RS12685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NEH16_RS12690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NEH16_RS12695	COG0089	rRNA binding
NEH16_RS12700	COG0088	Forms part of the polypeptide exit tunnel
NEH16_RS12705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NEH16_RS12710	COG0051	transcription antitermination factor activity, RNA binding
NEH16_RS12750	COG1073	alpha beta
NEH16_RS12810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NEH16_RS12815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NEH16_RS12820	COG0049	tRNA binding
NEH16_RS12825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NEH16_RS12830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NEH16_RS12835	COG0085	RNA polymerase activity
NEH16_RS12840	COG0222	ribosome binding
NEH16_RS12845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NEH16_RS12855	COG0081	regulation of translation
NEH16_RS12860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NEH16_RS12880	COG0436	Aminotransferase
NEH16_RS12905	COG0477	Major facilitator Superfamily
NEH16_RS12920	COG2030	dehydratase
NEH16_RS12925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NEH16_RS12945	COG0702	epimerase
NEH16_RS12955	COG1666	GTP binding
NEH16_RS12960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NEH16_RS12970	COG2261	transglycosylase associated protein
NEH16_RS12975	COG3304	Inner membrane component domain
NEH16_RS12980	COG0501	Belongs to the peptidase M48B family
NEH16_RS12990	COG1007	ATP synthesis coupled electron transport
NEH16_RS13005	COG0713	ATP synthesis coupled electron transport
NEH16_RS13010	COG0839	Belongs to the complex I subunit 6 family
NEH16_RS13015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEH16_RS13020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NEH16_RS13030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEH16_RS13035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEH16_RS13055	COG0674	pyruvate-flavodoxin oxidoreductase activity
NEH16_RS13055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NEH16_RS13060	COG1013	pyruvate-flavodoxin oxidoreductase activity
NEH16_RS13065	COG0702	epimerase
NEH16_RS13090	COG1595	DNA-templated transcription, initiation
NEH16_RS13115	COG0561	phosphatase activity
NEH16_RS13120	COG1309	transcriptional regulator
NEH16_RS13140	COG0142	geranyltranstransferase activity
NEH16_RS13145	COG3104	oligopeptide transport
NEH16_RS13155	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEH16_RS13165	COG1007	ATP synthesis coupled electron transport
NEH16_RS13175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NEH16_RS13180	COG0713	ATP synthesis coupled electron transport
NEH16_RS13185	COG0839	Belongs to the complex I subunit 6 family
NEH16_RS13190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEH16_RS13195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NEH16_RS13200	COG1034	ATP synthesis coupled electron transport
NEH16_RS13205	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NEH16_RS13215	COG0649	NAD binding
NEH16_RS13220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEH16_RS13225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEH16_RS13255	COG2226	methyltransferase
NEH16_RS13260	COG1595	DNA-templated transcription, initiation
NEH16_RS13285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NEH16_RS13295	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NEH16_RS13300	COG1278	Cold shock
NEH16_RS13340	COG1309	transcriptional regulator
NEH16_RS13350	COG2124	cytochrome p450
NEH16_RS13355	COG0501	Belongs to the peptidase M48B family
NEH16_RS13480	COG0464	growth
NEH16_RS13490	COG2072	flavoprotein involved in K transport
NEH16_RS13495	COG2814	Major facilitator Superfamily
NEH16_RS13520	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS13565	COG1131	(ABC) transporter
NEH16_RS13585	COG4821	SIS domain
NEH16_RS13595	COG0259	pyridoxamine-phosphate oxidase activity
NEH16_RS13620	COG1024	Enoyl-CoA hydratase
NEH16_RS13675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NEH16_RS13680	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS13695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEH16_RS13720	COG1733	regulation of RNA biosynthetic process
NEH16_RS13725	COG5006	permease, DMT superfamily
NEH16_RS13760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NEH16_RS13880	COG0667	Aldo Keto reductase
NEH16_RS13940	COG2267	carboxylic ester hydrolase activity
NEH16_RS13945	COG0667	Aldo Keto reductase
NEH16_RS13955	COG1846	Transcriptional regulator
NEH16_RS13965	COG2252	PERMEase
NEH16_RS13975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NEH16_RS13995	COG2814	Major facilitator Superfamily
NEH16_RS14005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NEH16_RS14010	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NEH16_RS14070	COG1061	Type III restriction enzyme res subunit
NEH16_RS14135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NEH16_RS14140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NEH16_RS14145	COG1263	PTS System
NEH16_RS14145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEH16_RS14255	COG0463	Glycosyl transferase, family 2
NEH16_RS14280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NEH16_RS14320	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NEH16_RS14345	COG0666	response to abiotic stimulus
NEH16_RS14355	COG4585	Histidine kinase
NEH16_RS14360	COG2197	response regulator
NEH16_RS14410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NEH16_RS14420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEH16_RS14425	COG0215	cysteine-tRNA ligase activity
NEH16_RS14430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NEH16_RS14435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NEH16_RS14440	COG1329	Transcriptional regulator
NEH16_RS14455	COG5002	protein histidine kinase activity
NEH16_RS14475	COG0588	phosphoglycerate mutase activity
NEH16_RS14500	COG0438	transferase activity, transferring glycosyl groups
NEH16_RS14545	COG2267	carboxylic ester hydrolase activity
NEH16_RS14555	COG4552	Acetyltransferase involved in intracellular survival and related
NEH16_RS14570	COG1490	D-aminoacyl-tRNA deacylase activity
NEH16_RS14575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NEH16_RS14585	COG3485	protocatechuate 3,4-dioxygenase
NEH16_RS14620	COG2897	thiosulfate sulfurtransferase activity
NEH16_RS14645	COG0745	RESPONSE REGULATOR receiver
NEH16_RS14650	COG1609	Transcriptional regulator
NEH16_RS14670	COG0737	Belongs to the 5'-nucleotidase family
NEH16_RS14675	COG0456	acetyltransferase
NEH16_RS14685	COG1131	(ABC) transporter
NEH16_RS14705	COG0406	alpha-ribazole phosphatase activity
NEH16_RS14705	COG0494	nUDIX hydrolase
NEH16_RS14710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NEH16_RS14730	COG0306	phosphate transporter
NEH16_RS14740	COG1937	Protein conserved in bacteria
NEH16_RS14760	COG0277	FAD linked oxidase domain protein
NEH16_RS14850	COG1131	(ABC) transporter
NEH16_RS14860	COG4585	Histidine kinase
NEH16_RS14865	COG2197	response regulator
NEH16_RS14885	COG1846	Transcriptional regulator
NEH16_RS14935	COG0579	oxidoreductase
NEH16_RS14940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NEH16_RS14950	COG0667	Aldo Keto reductase
NEH16_RS14955	COG0739	heme binding
NEH16_RS14955	COG0741	lytic transglycosylase activity
NEH16_RS14955	COG1196	nuclear chromosome segregation
NEH16_RS15015	COG0513	Belongs to the DEAD box helicase family
NEH16_RS15050	COG1643	Atp-dependent helicase
NEH16_RS15080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NEH16_RS15095	COG1309	transcriptional regulator
NEH16_RS15105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NEH16_RS15110	COG0047	phosphoribosylformylglycinamidine synthase activity
NEH16_RS15115	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NEH16_RS15150	COG2197	response regulator
NEH16_RS15160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NEH16_RS15175	COG0151	Belongs to the GarS family
NEH16_RS15240	COG2226	methyltransferase
NEH16_RS15270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NEH16_RS15295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NEH16_RS15310	COG0590	tRNA wobble adenosine to inosine editing
NEH16_RS15345	COG1191	sigma factor activity
NEH16_RS15350	COG1191	sigma factor activity
NEH16_RS15370	COG2353	YceI-like domain
NEH16_RS15375	COG3467	pyridoxamine 5'-phosphate
NEH16_RS15420	COG0745	RESPONSE REGULATOR receiver
NEH16_RS15435	COG1595	DNA-templated transcription, initiation
NEH16_RS15440	COG1252	NADH dehydrogenase
NEH16_RS15470	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS15475	COG1595	DNA-templated transcription, initiation
NEH16_RS15490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEH16_RS15505	COG0653	protein targeting
NEH16_RS15520	COG0006	proline dipeptidase activity
NEH16_RS15540	COG1999	signal sequence binding
NEH16_RS15550	COG2372	response to copper ion
NEH16_RS15555	COG2837	iron assimilation
NEH16_RS15565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NEH16_RS15570	COG0561	phosphatase activity
NEH16_RS15585	COG1131	(ABC) transporter
NEH16_RS15595	COG1131	(ABC) transporter
NEH16_RS15605	COG0789	Transcriptional regulator
NEH16_RS15610	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NEH16_RS15625	COG0561	phosphatase activity
NEH16_RS15635	COG4988	ABC transporter
NEH16_RS15640	COG1294	oxidase, subunit
NEH16_RS15645	COG1271	oxidase subunit
NEH16_RS15650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NEH16_RS15655	COG1609	Transcriptional regulator
NEH16_RS15660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NEH16_RS15670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NEH16_RS15695	COG0662	Cupin 2, conserved barrel domain protein
NEH16_RS15700	COG1950	PFAM Membrane protein of
NEH16_RS15705	COG0626	cystathionine gamma-synthase activity
NEH16_RS15725	COG2814	Major facilitator Superfamily
NEH16_RS15750	COG0305	Participates in initiation and elongation during chromosome replication
NEH16_RS15760	COG0359	binds to the 23S rRNA
NEH16_RS15765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NEH16_RS15770	COG0629	single-stranded DNA binding
NEH16_RS15775	COG0360	Binds together with S18 to 16S ribosomal RNA
NEH16_RS15800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NEH16_RS15825	COG0617	tRNA 3'-terminal CCA addition
NEH16_RS15840	COG0515	serine threonine protein kinase
NEH16_RS15840	COG2815	serine threonine protein kinase
NEH16_RS15845	COG1595	DNA-templated transcription, initiation
NEH16_RS15855	COG0492	ferredoxin-NADP+ reductase activity
NEH16_RS15860	COG3118	belongs to the thioredoxin family
NEH16_RS15875	COG1192	Involved in chromosome partitioning
NEH16_RS15880	COG0357	Ribosomal RNA small subunit methyltransferase G
NEH16_RS15890	COG0706	membrane insertase activity
NEH16_RS15895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NEH16_RS15900	COG0594	ribonuclease P activity
NEH16_RS15905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NEH16_RS15915	COG0592	DNA-directed DNA polymerase activity
NEH16_RS15920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NEH16_RS15925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NEH16_RS15930	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NEH16_RS15940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NEH16_RS15975	COG0515	serine threonine protein kinase
NEH16_RS16000	COG0705	Rhomboid family
NEH16_RS16030	COG3764	Sortase (surface protein transpeptidase)
NEH16_RS16035	COG0515	serine threonine protein kinase
NEH16_RS16040	COG0768	penicillin binding
NEH16_RS16055	COG1716	ATPase activity
NEH16_RS16090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEH16_RS16095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEH16_RS16100	COG2151	metal-sulfur cluster biosynthetic enzyme
NEH16_RS16105	COG3396	Phenylacetate-CoA oxygenase
NEH16_RS16110	COG3460	Phenylacetate-CoA oxygenase
NEH16_RS16115	COG3396	Phenylacetate-CoA oxygenase
NEH16_RS16140	COG1309	transcriptional regulator
NEH16_RS16145	COG1522	sequence-specific DNA binding
NEH16_RS16170	COG0303	'Molybdopterin
NEH16_RS16195	COG1136	(ABC) transporter
NEH16_RS16195	COG4591	ABC-type transport system involved in lipoprotein release permease component
NEH16_RS16210	COG0515	serine threonine protein kinase
NEH16_RS16215	COG0515	serine threonine protein kinase
NEH16_RS16240	COG0022	dehydrogenase e1 component
NEH16_RS16265	COG1309	transcriptional regulator
NEH16_RS16275	COG3467	pyridoxamine 5'-phosphate
NEH16_RS16290	COG0148	phosphopyruvate hydratase activity
NEH16_RS16315	COG0519	Catalyzes the synthesis of GMP from XMP
NEH16_RS16320	COG1802	Transcriptional regulator
NEH16_RS16325	COG2271	Major facilitator Superfamily
NEH16_RS16360	COG1362	aminopeptidase activity
NEH16_RS16365	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS16375	COG1741	Belongs to the pirin family
NEH16_RS16385	COG2172	sigma factor antagonist activity
NEH16_RS16385	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS16385	COG2208	phosphoserine phosphatase activity
NEH16_RS16390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NEH16_RS16400	COG0745	RESPONSE REGULATOR receiver
NEH16_RS16405	COG2205	protein histidine kinase activity
NEH16_RS16420	COG1063	alcohol dehydrogenase
NEH16_RS16450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS16455	COG0346	lactoylglutathione lyase activity
NEH16_RS16465	COG2255	four-way junction helicase activity
NEH16_RS16500	COG0475	glutathione-regulated potassium exporter activity
NEH16_RS16505	COG0490	domain, Protein
NEH16_RS16510	COG2268	Band 7 protein
NEH16_RS16565	COG0513	Belongs to the DEAD box helicase family
NEH16_RS16570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NEH16_RS16575	COG1993	acr, cog1993
NEH16_RS16580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NEH16_RS16600	COG0346	lactoylglutathione lyase activity
NEH16_RS16620	COG2197	response regulator
NEH16_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS16655	COG1309	transcriptional regulator
NEH16_RS16755	COG0717	Belongs to the dCTP deaminase family
NEH16_RS16760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NEH16_RS16770	COG2181	nitrate reductase activity
NEH16_RS16770	COG0247	lactate metabolic process
NEH16_RS16775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NEH16_RS16780	COG0443	Heat shock 70 kDa protein
NEH16_RS16785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NEH16_RS16790	COG0484	heat shock protein binding
NEH16_RS16795	COG0789	Transcriptional regulator
NEH16_RS16820	COG0542	response to heat
NEH16_RS16845	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NEH16_RS16860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NEH16_RS16865	COG0191	fructose-bisphosphate aldolase activity
NEH16_RS16870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NEH16_RS16875	COG0477	Major facilitator Superfamily
NEH16_RS16890	COG3844	kynureninase activity
NEH16_RS16900	COG4585	Histidine kinase
NEH16_RS16905	COG2197	response regulator
NEH16_RS16910	COG2124	cytochrome p450
NEH16_RS16915	COG3559	Exporter of polyketide antibiotics
NEH16_RS16920	COG1131	(ABC) transporter
NEH16_RS16935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NEH16_RS16940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NEH16_RS16950	COG0592	DNA-directed DNA polymerase activity
NEH16_RS16960	COG1802	Transcriptional regulator
NEH16_RS16975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NEH16_RS16980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NEH16_RS17000	COG1595	DNA-templated transcription, initiation
NEH16_RS17020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NEH16_RS17025	COG2755	lipolytic protein G-D-S-L family
NEH16_RS17050	COG1610	YqeY-like protein
NEH16_RS17055	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NEH16_RS17065	COG0003	Pfam Anion-transporting ATPase
NEH16_RS17120	COG2267	carboxylic ester hydrolase activity
NEH16_RS17130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NEH16_RS17135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEH16_RS17210	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS17215	COG2172	sigma factor antagonist activity
NEH16_RS17225	COG2890	protein-(glutamine-N5) methyltransferase activity
NEH16_RS17235	COG1131	(ABC) transporter
NEH16_RS17260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NEH16_RS17265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NEH16_RS17280	COG0501	Belongs to the peptidase M48B family
NEH16_RS17290	COG0791	NLP P60 protein
NEH16_RS17290	COG0741	lytic transglycosylase activity
NEH16_RS17390	COG3507	Belongs to the glycosyl hydrolase 43 family
NEH16_RS17400	COG1309	transcriptional regulator
NEH16_RS17405	COG2197	response regulator
NEH16_RS17415	COG0577	efflux transmembrane transporter activity
NEH16_RS17415	COG1136	(ABC) transporter
NEH16_RS17440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEH16_RS17440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEH16_RS17475	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS17495	COG0789	Transcriptional regulator
NEH16_RS17510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NEH16_RS17515	COG2027	D-alanyl-D-alanine carboxypeptidase
NEH16_RS17525	COG0037	tRNA processing
NEH16_RS17540	COG0302	gtp cyclohydrolase
NEH16_RS17555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NEH16_RS17560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NEH16_RS17585	COG1125	glycine betaine transport
NEH16_RS17585	COG0517	IMP dehydrogenase activity
NEH16_RS17590	COG1174	glycine betaine transport
NEH16_RS17595	COG1174	glycine betaine transport
NEH16_RS17625	COG2197	response regulator
NEH16_RS17630	COG0640	Transcriptional regulator
NEH16_RS17635	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NEH16_RS17645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NEH16_RS17660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NEH16_RS17680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NEH16_RS17705	COG0739	heme binding
NEH16_RS17715	COG0477	Major facilitator Superfamily
NEH16_RS17720	COG2205	protein histidine kinase activity
NEH16_RS17725	COG0745	RESPONSE REGULATOR receiver
NEH16_RS17735	COG1595	DNA-templated transcription, initiation
NEH16_RS17740	COG1194	a g-specific adenine glycosylase
NEH16_RS17750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NEH16_RS17770	COG0248	Ppx GppA phosphatase
NEH16_RS17775	COG1082	Xylose isomerase domain protein TIM barrel
NEH16_RS17785	COG0129	dihydroxy-acid dehydratase activity
NEH16_RS17800	COG1129	ABC transporter
NEH16_RS17800	COG0842	Transport permease protein
NEH16_RS17810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NEH16_RS17830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEH16_RS17835	COG2223	nitrite transmembrane transporter activity
NEH16_RS17890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NEH16_RS17895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NEH16_RS17945	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NEH16_RS17965	COG1690	Belongs to the RtcB family
NEH16_RS17975	COG1742	UPF0060 membrane protein
NEH16_RS17980	COG1846	Transcriptional regulator
NEH16_RS18015	COG2814	Major facilitator Superfamily
NEH16_RS18025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NEH16_RS18030	COG0406	alpha-ribazole phosphatase activity
NEH16_RS18045	COG0785	Cytochrome C biogenesis protein
NEH16_RS18050	COG1333	cytochrome c biogenesis protein
NEH16_RS18055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NEH16_RS18070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NEH16_RS18075	COG0109	protoheme IX farnesyltransferase activity
NEH16_RS18085	COG0163	prenyltransferase activity
NEH16_RS18100	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NEH16_RS18130	COG1309	transcriptional regulator
NEH16_RS18140	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS18145	COG0183	Belongs to the thiolase family
NEH16_RS18195	COG2226	methyltransferase
NEH16_RS18195	COG2267	carboxylic ester hydrolase activity
NEH16_RS18225	COG3973	AAA domain
NEH16_RS18230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEH16_RS18230	COG0515	serine threonine protein kinase
NEH16_RS18235	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NEH16_RS18290	COG0018	arginyl-trna synthetase
NEH16_RS18355	COG1846	Transcriptional regulator
NEH16_RS18360	COG3384	dioxygenase
NEH16_RS18380	COG0477	Major facilitator Superfamily
NEH16_RS18390	COG3191	aminopeptidase activity
NEH16_RS18405	COG0243	molybdopterin cofactor binding
NEH16_RS18410	COG0437	4 iron, 4 sulfur cluster binding
NEH16_RS18450	COG3263	regulation of cellular component size
NEH16_RS18460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NEH16_RS18475	COG0315	cyclic pyranopterin monophosphate synthase activity
NEH16_RS18480	COG0315	cyclic pyranopterin monophosphate synthase activity
NEH16_RS18480	COG0521	Mo-molybdopterin cofactor biosynthetic process
NEH16_RS18540	COG0708	Exodeoxyribonuclease III
NEH16_RS18545	COG3903	Transcriptional regulator
NEH16_RS18545	COG3629	intracellular signal transduction
NEH16_RS18555	COG0789	Transcriptional regulator
NEH16_RS18560	COG2072	flavoprotein involved in K transport
NEH16_RS18655	COG3118	belongs to the thioredoxin family
NEH16_RS18660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NEH16_RS18670	COG2318	DinB family
NEH16_RS18675	COG1595	DNA-templated transcription, initiation
NEH16_RS18680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEH16_RS18685	COG0789	Transcriptional regulator
NEH16_RS18700	COG0793	Belongs to the peptidase S41A family
NEH16_RS18700	COG4946	Tricorn protease homolog
NEH16_RS18705	COG1309	transcriptional regulator
NEH16_RS18710	COG2409	Drug exporters of the RND superfamily
NEH16_RS18720	COG0310	cobalt ion transport
NEH16_RS18730	COG1122	ATPase activity
NEH16_RS18735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEH16_RS18750	COG0583	DNA-binding transcription factor activity
NEH16_RS18760	COG0494	nUDIX hydrolase
NEH16_RS18815	COG0583	DNA-binding transcription factor activity
NEH16_RS18820	COG0697	spore germination
NEH16_RS18855	COG0084	hydrolase, TatD family'
NEH16_RS18860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NEH16_RS18865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NEH16_RS18875	COG0488	(ABC) transporter
NEH16_RS18905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEH16_RS18930	COG2197	response regulator
NEH16_RS18935	COG1846	Transcriptional regulator
NEH16_RS18940	COG4106	trans-aconitate 2-methyltransferase activity
NEH16_RS18970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NEH16_RS18980	COG0193	aminoacyl-tRNA hydrolase activity
NEH16_RS18985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NEH16_RS18990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NEH16_RS19005	COG4585	Histidine kinase
NEH16_RS19060	COG1136	(ABC) transporter
NEH16_RS19065	COG0577	efflux transmembrane transporter activity
NEH16_RS19095	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS19100	COG1309	transcriptional regulator
NEH16_RS19120	COG2815	serine threonine protein kinase
NEH16_RS19120	COG0515	serine threonine protein kinase
NEH16_RS19125	COG0463	Glycosyl transferase, family 2
NEH16_RS19145	COG2124	cytochrome p450
NEH16_RS19160	COG0148	phosphopyruvate hydratase activity
NEH16_RS19180	COG1252	NADH dehydrogenase
NEH16_RS19185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NEH16_RS19190	COG2177	Part of the ABC transporter FtsEX involved in
NEH16_RS19195	COG1136	(ABC) transporter
NEH16_RS19200	COG1609	Transcriptional regulator
NEH16_RS19210	COG0601	transmembrane transport
NEH16_RS19225	COG4608	Belongs to the ABC transporter superfamily
NEH16_RS19240	COG2318	DinB family
NEH16_RS19260	COG0183	Belongs to the thiolase family
NEH16_RS19265	COG2755	lipolytic protein G-D-S-L family
NEH16_RS19280	COG4221	oxidoreductase activity
NEH16_RS19290	COG1595	DNA-templated transcription, initiation
NEH16_RS19325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NEH16_RS19340	COG1228	amidohydrolase
NEH16_RS19345	COG1191	sigma factor activity
NEH16_RS19350	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS19360	COG3104	oligopeptide transport
NEH16_RS19365	COG0745	RESPONSE REGULATOR receiver
NEH16_RS19370	COG2205	protein histidine kinase activity
NEH16_RS19400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NEH16_RS19460	COG2226	methyltransferase
NEH16_RS19465	COG1316	TRANSCRIPTIONal
NEH16_RS19470	COG1607	acyl-coa hydrolase
NEH16_RS19475	COG1316	TRANSCRIPTIONal
NEH16_RS19490	COG1316	TRANSCRIPTIONal
NEH16_RS19495	COG1316	TRANSCRIPTIONal
NEH16_RS19515	COG0778	Nitroreductase
NEH16_RS19515	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NEH16_RS19520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NEH16_RS19555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NEH16_RS19570	COG1482	cell wall glycoprotein biosynthetic process
NEH16_RS19580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NEH16_RS19625	COG0745	RESPONSE REGULATOR receiver
NEH16_RS19630	COG5002	protein histidine kinase activity
NEH16_RS19630	COG5000	phosphorelay sensor kinase activity
NEH16_RS19635	COG0823	Involved in the tonB-independent uptake of proteins
NEH16_RS19645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NEH16_RS19650	COG2197	response regulator
NEH16_RS19665	COG0653	protein targeting
NEH16_RS19705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NEH16_RS19730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NEH16_RS19735	COG0395	ABC-type sugar transport system, permease component
NEH16_RS19740	COG1175	transmembrane transport
NEH16_RS19745	COG1653	transport
NEH16_RS19760	COG1716	ATPase activity
NEH16_RS19765	COG0515	serine threonine protein kinase
NEH16_RS19770	COG0515	serine threonine protein kinase
NEH16_RS19790	COG2884	Cell division ATP-binding protein ftsE
NEH16_RS19795	COG2177	Part of the ABC transporter FtsEX involved in
NEH16_RS19805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NEH16_RS19830	COG2223	nitrite transmembrane transporter activity
NEH16_RS19840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEH16_RS19850	COG3973	AAA domain
NEH16_RS19860	COG0776	regulation of translation
NEH16_RS19865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NEH16_RS19890	COG0395	ABC-type sugar transport system, permease component
NEH16_RS19895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NEH16_RS19945	COG1174	glycine betaine transport
NEH16_RS19950	COG0517	IMP dehydrogenase activity
NEH16_RS19950	COG1125	glycine betaine transport
NEH16_RS19955	COG1174	glycine betaine transport
NEH16_RS19965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NEH16_RS19975	COG0277	FAD linked oxidase domain protein
NEH16_RS20010	COG1335	isochorismatase
NEH16_RS20020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NEH16_RS20030	COG1113	amino acid transport
NEH16_RS20060	COG1263	PTS System
NEH16_RS20070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEH16_RS20075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NEH16_RS20090	COG1309	transcriptional regulator
NEH16_RS20095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NEH16_RS20110	COG0477	Major facilitator Superfamily
NEH16_RS20150	COG4555	ABC transporter
NEH16_RS20165	COG2733	membrane
NEH16_RS20195	COG1309	transcriptional regulator
NEH16_RS20210	COG0110	maltose O-acetyltransferase activity
NEH16_RS20220	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
NEH16_RS20250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NEH16_RS20260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NEH16_RS20300	COG1131	(ABC) transporter
NEH16_RS20335	COG3629	intracellular signal transduction
NEH16_RS20335	COG3903	Transcriptional regulator
NEH16_RS20390	COG0270	DNA (cytosine-5-)-methyltransferase activity
NEH16_RS20425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEH16_RS20445	COG4702	Belongs to the UPF0303 family
NEH16_RS20450	COG0673	inositol 2-dehydrogenase activity
NEH16_RS20495	COG3397	chitin binding
NEH16_RS20500	COG0477	Major facilitator Superfamily
NEH16_RS20515	COG1126	abc transporter atp-binding protein
NEH16_RS20520	COG0765	amino acid transport
NEH16_RS20525	COG0765	amino acid transport
NEH16_RS20530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEH16_RS20540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS20590	COG0406	alpha-ribazole phosphatase activity
NEH16_RS20605	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NEH16_RS20615	COG0745	RESPONSE REGULATOR receiver
NEH16_RS20630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEH16_RS20635	COG2186	Transcriptional regulator
NEH16_RS20650	COG0395	ABC-type sugar transport system, permease component
NEH16_RS20730	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS20745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEH16_RS20750	COG1309	transcriptional regulator
NEH16_RS20765	COG1946	Acyl-CoA thioesterase
NEH16_RS20850	COG1674	ftsk spoiiie
NEH16_RS20875	COG0028	Belongs to the TPP enzyme family
NEH16_RS20895	COG0515	serine threonine protein kinase
NEH16_RS20895	COG2815	serine threonine protein kinase
NEH16_RS20920	COG1472	Belongs to the glycosyl hydrolase 3 family
NEH16_RS20940	COG1609	Transcriptional regulator
NEH16_RS20945	COG0673	inositol 2-dehydrogenase activity
NEH16_RS20960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NEH16_RS20990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEH16_RS20995	COG3718	enzyme involved in inositol metabolism
NEH16_RS21065	COG0629	single-stranded DNA binding
NEH16_RS21095	COG1136	(ABC) transporter
NEH16_RS21095	COG0577	efflux transmembrane transporter activity
NEH16_RS21150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEH16_RS21165	COG1486	melibiose metabolic process
NEH16_RS21170	COG0395	ABC-type sugar transport system, permease component
NEH16_RS21175	COG1175	transmembrane transport
NEH16_RS21185	COG1940	carbohydrate kinase activity
NEH16_RS21190	COG0668	transmembrane transport
NEH16_RS21200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NEH16_RS21200	COG3291	Pkd domain containing protein
NEH16_RS21225	COG4266	Belongs to the allantoicase family
NEH16_RS21230	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS21235	COG1366	Belongs to the anti-sigma-factor antagonist family
NEH16_RS21240	COG2172	sigma factor antagonist activity
NEH16_RS21250	COG2205	protein histidine kinase activity
NEH16_RS21250	COG2198	Histidine kinase
NEH16_RS21250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEH16_RS21250	COG0784	Response regulator, receiver
NEH16_RS21255	COG0745	RESPONSE REGULATOR receiver
NEH16_RS21290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NEH16_RS21310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NEH16_RS21315	COG1113	amino acid transport
NEH16_RS21340	COG0475	glutathione-regulated potassium exporter activity
NEH16_RS21350	COG3594	Acyltransferase
NEH16_RS21370	COG0544	peptidyl-prolyl cis-trans isomerase activity
NEH16_RS21375	COG0740	serine-type endopeptidase activity
NEH16_RS21380	COG0740	serine-type endopeptidase activity
NEH16_RS21385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NEH16_RS21400	COG0285	dihydrofolate synthase activity
NEH16_RS21410	COG0105	UTP biosynthetic process
NEH16_RS21415	COG1077	Cell shape determining protein MreB Mrl
NEH16_RS21435	COG0772	Belongs to the SEDS family
NEH16_RS21465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NEH16_RS21480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NEH16_RS21485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NEH16_RS21490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NEH16_RS21495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NEH16_RS21525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NEH16_RS21535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NEH16_RS21550	COG0501	Belongs to the peptidase M48B family
NEH16_RS21565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NEH16_RS21575	COG0799	negative regulation of ribosome biogenesis
NEH16_RS21580	COG0588	phosphoglycerate mutase activity
NEH16_RS21610	COG0495	leucyl-tRNA aminoacylation
NEH16_RS21620	COG1307	EDD domain protein, DegV family
NEH16_RS21625	COG1555	photosystem II stabilization
NEH16_RS21660	COG0268	Binds directly to 16S ribosomal RNA
NEH16_RS21665	COG0481	GTPase activity
NEH16_RS21700	COG1420	regulation of RNA biosynthetic process
NEH16_RS21705	COG0484	heat shock protein binding
NEH16_RS21710	COG2070	2-Nitropropane dioxygenase
NEH16_RS21730	COG0537	adenosine 5'-monophosphoramidase activity
NEH16_RS21735	COG1234	tRNA 3'-trailer cleavage
NEH16_RS21740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NEH16_RS21750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEH16_RS21760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NEH16_RS21770	COG2315	Protein conserved in bacteria
NEH16_RS21795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEH16_RS21805	COG1381	Involved in DNA repair and RecF pathway recombination
NEH16_RS21810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NEH16_RS21820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NEH16_RS21830	COG3443	Belongs to the bacterial solute-binding protein 9 family
NEH16_RS21830	COG0803	Belongs to the bacterial solute-binding protein 9 family
NEH16_RS21835	COG0423	glycine-tRNA ligase activity
NEH16_RS21845	COG0477	Major facilitator Superfamily
NEH16_RS21870	COG0574	Belongs to the PEP-utilizing enzyme family
NEH16_RS21870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEH16_RS21885	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS21895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NEH16_RS21895	COG2146	nitrite reductase [NAD(P)H] activity
NEH16_RS21935	COG2949	membrane
NEH16_RS21940	COG0561	phosphatase activity
NEH16_RS21950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NEH16_RS21960	COG0358	DNA primase activity
NEH16_RS21965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NEH16_RS21980	COG1070	Carbohydrate kinase
NEH16_RS22005	COG0477	Major facilitator Superfamily
NEH16_RS22015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NEH16_RS22015	COG0825	malonyl-CoA metabolic process
NEH16_RS22020	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS22030	COG1522	sequence-specific DNA binding
NEH16_RS22055	COG2130	NADP-dependent
NEH16_RS22060	COG1764	response to oxidative stress
NEH16_RS22085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEH16_RS22090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NEH16_RS22095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEH16_RS22125	COG3511	phospholipase C
NEH16_RS22135	COG0789	Transcriptional regulator
NEH16_RS22140	COG0667	Aldo Keto reductase
NEH16_RS22155	COG2197	response regulator
NEH16_RS22160	COG4585	Histidine kinase
NEH16_RS22180	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NEH16_RS22225	COG1358	cellular component organization or biogenesis
NEH16_RS22295	COG0789	Transcriptional regulator
NEH16_RS22340	COG0477	Major facilitator Superfamily
NEH16_RS22360	COG2259	Doxx family
NEH16_RS22445	COG1657	PFAM Prenyltransferase squalene oxidase
NEH16_RS22470	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS22490	COG0559	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS22510	COG1309	transcriptional regulator
NEH16_RS22515	COG0438	transferase activity, transferring glycosyl groups
NEH16_RS22545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NEH16_RS22545	COG1796	DNA polymerase
NEH16_RS22565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEH16_RS22570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NEH16_RS22580	COG1414	Transcriptional regulator
NEH16_RS22585	COG3340	Belongs to the peptidase S51 family
NEH16_RS22610	COG4585	Histidine kinase
NEH16_RS22620	COG1131	(ABC) transporter
NEH16_RS22635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NEH16_RS22650	COG0800	Aldolase
NEH16_RS22655	COG3022	response to hydroperoxide
NEH16_RS22685	COG2235	arginine
NEH16_RS22695	COG0789	Transcriptional regulator
NEH16_RS22700	COG1819	glycosyl
NEH16_RS22720	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS22725	COG3540	Alkaline phosphatase
NEH16_RS22735	COG2814	Major facilitator Superfamily
NEH16_RS22745	COG1834	amidinotransferase
NEH16_RS22760	COG0672	)-iron permease
NEH16_RS22765	COG2837	iron assimilation
NEH16_RS22775	COG1120	ATPase activity
NEH16_RS22780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS22785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NEH16_RS22805	COG5398	heme oxygenase
NEH16_RS22865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NEH16_RS22870	COG0477	Major facilitator Superfamily
NEH16_RS22885	COG2814	Major facilitator Superfamily
NEH16_RS22890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NEH16_RS22890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NEH16_RS22905	COG0174	glutamine synthetase
NEH16_RS22955	COG2890	protein-(glutamine-N5) methyltransferase activity
NEH16_RS22960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NEH16_RS22970	COG1609	Transcriptional regulator
NEH16_RS22985	COG3833	ABC-type maltose transport systems, permease component
NEH16_RS22990	COG0366	Alpha amylase catalytic
NEH16_RS23070	COG2197	response regulator
NEH16_RS23085	COG0745	RESPONSE REGULATOR receiver
NEH16_RS23140	COG0659	secondary active sulfate transmembrane transporter activity
NEH16_RS23170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NEH16_RS23175	COG0321	lipoyl(octanoyl) transferase activity
NEH16_RS23220	COG0508	dehydrogenase complex catalyzes the overall conversion of
NEH16_RS23225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEH16_RS23230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NEH16_RS23240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NEH16_RS23255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NEH16_RS23270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEH16_RS23275	COG4106	trans-aconitate 2-methyltransferase activity
NEH16_RS23300	COG2197	response regulator
NEH16_RS23350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NEH16_RS23370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEH16_RS23380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NEH16_RS23385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NEH16_RS23395	COG1376	ErfK ybiS ycfS ynhG family protein
NEH16_RS23405	COG1845	cytochrome c oxidase, subunit III
NEH16_RS23415	COG0723	plastoquinol--plastocyanin reductase activity
NEH16_RS23420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NEH16_RS23425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NEH16_RS23430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NEH16_RS23495	COG0003	Pfam Anion-transporting ATPase
NEH16_RS23505	COG1940	carbohydrate kinase activity
NEH16_RS23530	COG2197	response regulator
NEH16_RS23535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NEH16_RS23550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NEH16_RS23560	COG2193	ferroxidase activity
NEH16_RS23565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NEH16_RS23570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NEH16_RS23575	COG0515	serine threonine protein kinase
NEH16_RS23575	COG2815	serine threonine protein kinase
NEH16_RS23580	COG2022	thiamine diphosphate biosynthetic process
NEH16_RS23590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEH16_RS23590	COG2022	thiamine diphosphate biosynthetic process
NEH16_RS23605	COG0352	thiamine-phosphate diphosphorylase activity
NEH16_RS23620	COG1233	COG1233 Phytoene dehydrogenase and related
NEH16_RS23640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NEH16_RS23650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NEH16_RS23670	COG0714	Associated with various cellular activities
NEH16_RS23680	COG0275	rRNA processing
NEH16_RS23690	COG0768	penicillin binding
NEH16_RS23695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NEH16_RS23705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NEH16_RS23710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NEH16_RS23720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NEH16_RS23725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NEH16_RS23740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NEH16_RS23745	COG1799	cell septum assembly
NEH16_RS23760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NEH16_RS23770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NEH16_RS23815	COG0587	DNA-directed DNA polymerase activity
NEH16_RS23825	COG1432	Conserved Protein
NEH16_RS23845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NEH16_RS23865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NEH16_RS23870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NEH16_RS23875	COG0131	Imidazoleglycerol-phosphate dehydratase
NEH16_RS23885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NEH16_RS23890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NEH16_RS23895	COG0251	oxidation-reduction process
NEH16_RS23900	COG0107	imidazoleglycerol-phosphate synthase activity
NEH16_RS23910	COG2508	Transcriptional regulator
NEH16_RS23930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NEH16_RS23955	COG0134	indole-3-glycerol-phosphate synthase activity
NEH16_RS23965	COG0133	tryptophan synthase activity
NEH16_RS23970	COG0159	tryptophan synthase activity
NEH16_RS23980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NEH16_RS23990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NEH16_RS23995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEH16_RS24045	COG1278	Cold shock
NEH16_RS24070	COG1605	Chorismate mutase
NEH16_RS24070	COG0287	Prephenate dehydrogenase
NEH16_RS24075	COG2271	Major facilitator Superfamily
NEH16_RS24080	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS24105	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS24135	COG1846	Transcriptional regulator
NEH16_RS24155	COG0737	Belongs to the 5'-nucleotidase family
NEH16_RS24210	COG2050	protein possibly involved in aromatic compounds catabolism
NEH16_RS24235	COG1643	Atp-dependent helicase
NEH16_RS24260	COG0237	dephospho-CoA kinase activity
NEH16_RS24275	COG2365	Tyrosine phosphatase family
NEH16_RS24285	COG2755	lipolytic protein G-D-S-L family
NEH16_RS24290	COG3835	regulator
NEH16_RS24295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NEH16_RS24305	COG0330	HflC and HflK could
NEH16_RS24310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NEH16_RS24320	COG1309	transcriptional regulator
NEH16_RS24370	COG2313	pseudouridylate synthase activity
NEH16_RS24375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NEH16_RS24380	COG0584	glycerophosphoryl diester phosphodiesterase
NEH16_RS24390	COG0556	nucleotide-excision repair
NEH16_RS24420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NEH16_RS24445	COG0322	excinuclease ABC activity
NEH16_RS24450	COG1660	Displays ATPase and GTPase activities
NEH16_RS24455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NEH16_RS24465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEH16_RS24470	COG0126	phosphoglycerate kinase activity
NEH16_RS24475	COG0149	triose-phosphate isomerase activity
NEH16_RS24480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NEH16_RS24490	COG0166	Belongs to the GPI family
NEH16_RS24500	COG0363	glucosamine-6-phosphate deaminase activity
NEH16_RS24515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NEH16_RS24525	COG0109	protoheme IX farnesyltransferase activity
NEH16_RS24570	COG0396	ATPase activity
NEH16_RS24575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NEH16_RS24580	COG0822	iron-sulfur transferase activity
NEH16_RS24600	COG2076	Multidrug Resistance protein
NEH16_RS24605	COG3226	Transcriptional regulator
NEH16_RS24620	COG2171	N-acyltransferase activity
NEH16_RS24625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NEH16_RS24660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEH16_RS24665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NEH16_RS24680	COG1802	Transcriptional regulator
NEH16_RS24700	COG0395	ABC-type sugar transport system, permease component
NEH16_RS24720	COG1653	transport
NEH16_RS24725	COG3866	Pectate lyase
NEH16_RS24730	COG4677	pectinesterase activity
NEH16_RS24750	COG1414	Transcriptional regulator
NEH16_RS24810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NEH16_RS24840	COG1797	cobyrinic acid a,c-diamide synthase activity
NEH16_RS24845	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NEH16_RS24855	COG1492	cobalamin metabolic process
NEH16_RS24860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NEH16_RS24875	COG0235	Class ii aldolase
NEH16_RS24900	COG0488	(ABC) transporter
NEH16_RS24965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NEH16_RS24990	COG1404	Belongs to the peptidase S8 family
NEH16_RS25000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEH16_RS25020	COG2261	transglycosylase associated protein
NEH16_RS25025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NEH16_RS25040	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS25045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NEH16_RS25055	COG2186	Transcriptional regulator
NEH16_RS25080	COG3830	Belongs to the UPF0237 family
NEH16_RS25080	COG0560	Phosphoserine phosphatase
NEH16_RS25085	COG0842	Transport permease protein
NEH16_RS25085	COG1131	(ABC) transporter
NEH16_RS25085	COG1716	ATPase activity
NEH16_RS25100	COG2197	response regulator
NEH16_RS25110	COG1119	ATPase activity
NEH16_RS25135	COG1881	PFAM PEBP family protein
NEH16_RS25175	COG0647	UMP catabolic process
NEH16_RS25180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS25185	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS25190	COG1120	ATPase activity
NEH16_RS25210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NEH16_RS25215	COG0497	DNA recombination
NEH16_RS25220	COG0297	glycogen (starch) synthase activity
NEH16_RS25225	COG2897	thiosulfate sulfurtransferase activity
NEH16_RS25230	COG3387	PFAM Glycoside hydrolase 15-related
NEH16_RS25235	COG0504	CTP synthase activity
NEH16_RS25240	COG0494	nUDIX hydrolase
NEH16_RS25250	COG0686	Belongs to the AlaDH PNT family
NEH16_RS25270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NEH16_RS25315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NEH16_RS25345	COG0671	phosphoesterase, PA-phosphatase related
NEH16_RS25350	COG0477	Major facilitator Superfamily
NEH16_RS25355	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS25360	COG1799	cell septum assembly
NEH16_RS25375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS25405	COG0587	DNA-directed DNA polymerase activity
NEH16_RS25410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEH16_RS25435	COG1725	Transcriptional regulator
NEH16_RS25440	COG2755	lipolytic protein G-D-S-L family
NEH16_RS25450	COG1309	transcriptional regulator
NEH16_RS25460	COG2188	Transcriptional regulator
NEH16_RS25465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NEH16_RS25485	COG1309	transcriptional regulator
NEH16_RS25490	COG3842	ATPase activity
NEH16_RS25510	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS25545	COG3876	Protein conserved in bacteria
NEH16_RS25550	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS25555	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS25575	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS25585	COG4948	Mandelate Racemase Muconate Lactonizing
NEH16_RS25600	COG2149	membrane
NEH16_RS25605	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NEH16_RS25630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NEH16_RS25645	COG3265	gluconokinase activity
NEH16_RS25650	COG2186	Transcriptional regulator
NEH16_RS25665	COG0564	pseudouridine synthase activity
NEH16_RS25700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEH16_RS25735	COG0667	Aldo Keto reductase
NEH16_RS25740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS25750	COG0598	Magnesium transport protein CorA
NEH16_RS25770	COG0215	cysteine-tRNA ligase activity
NEH16_RS25785	COG4948	Mandelate Racemase Muconate Lactonizing
NEH16_RS25790	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS25800	COG1129	ABC transporter
NEH16_RS25805	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS25810	COG2186	Transcriptional regulator
NEH16_RS25815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NEH16_RS25820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NEH16_RS25825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NEH16_RS25830	COG1414	Transcriptional regulator
NEH16_RS25845	COG0747	negative chemotaxis
NEH16_RS25850	COG2197	response regulator
NEH16_RS25860	COG0517	IMP dehydrogenase activity
NEH16_RS25860	COG1994	Peptidase M50
NEH16_RS25880	COG1222	aaa ATPase
NEH16_RS25885	COG4122	O-methyltransferase activity
NEH16_RS25900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NEH16_RS25905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NEH16_RS25920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NEH16_RS25925	COG0545	Peptidyl-prolyl cis-trans isomerase
NEH16_RS25935	COG2378	regulation of single-species biofilm formation
NEH16_RS25955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEH16_RS25960	COG0805	protein transport
NEH16_RS26000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NEH16_RS26020	COG1595	DNA-templated transcription, initiation
NEH16_RS26045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEH16_RS26050	COG4175	Glycine betaine
NEH16_RS26050	COG0517	IMP dehydrogenase activity
NEH16_RS26065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NEH16_RS26115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NEH16_RS26130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NEH16_RS26135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NEH16_RS26140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEH16_RS26145	COG5002	protein histidine kinase activity
NEH16_RS26150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NEH16_RS26155	COG0072	phenylalanine-tRNA ligase activity
NEH16_RS26155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEH16_RS26175	COG1649	PFAM Uncharacterised BCR, COG1649
NEH16_RS26185	COG0697	spore germination
NEH16_RS26190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEH16_RS26210	COG2318	DinB family
NEH16_RS26235	COG4977	sequence-specific DNA binding
NEH16_RS26245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NEH16_RS26250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NEH16_RS26255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NEH16_RS26260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NEH16_RS26265	COG1438	arginine binding
NEH16_RS26280	COG0165	Argininosuccinate lyase
NEH16_RS26295	COG0477	Major facilitator Superfamily
NEH16_RS26330	COG2011	ABC-type metal ion transport system permease component
NEH16_RS26335	COG1464	Belongs to the NlpA lipoprotein family
NEH16_RS26355	COG1648	precorrin-2 dehydrogenase activity
NEH16_RS26355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NEH16_RS26415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NEH16_RS26425	COG0454	-acetyltransferase
NEH16_RS26440	COG3458	cephalosporin-C deacetylase activity
NEH16_RS26480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEH16_RS26495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NEH16_RS26500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEH16_RS26520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NEH16_RS26525	COG1560	Kdo2-lipid A biosynthetic process
NEH16_RS26530	COG0438	transferase activity, transferring glycosyl groups
NEH16_RS26540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NEH16_RS26545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NEH16_RS26550	COG0217	transcriptional regulatory protein
NEH16_RS26555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NEH16_RS26560	COG0632	four-way junction helicase activity
NEH16_RS26575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NEH16_RS26580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NEH16_RS26585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NEH16_RS26595	COG1196	nuclear chromosome segregation
NEH16_RS26610	COG0124	histidyl-tRNA synthetase
NEH16_RS26630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NEH16_RS26650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NEH16_RS26655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NEH16_RS26660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NEH16_RS26665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NEH16_RS26670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NEH16_RS26675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NEH16_RS26680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NEH16_RS26685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NEH16_RS26700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NEH16_RS26705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NEH16_RS26720	COG0540	Belongs to the ATCase OTCase family
NEH16_RS26725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NEH16_RS26735	COG0505	Belongs to the CarA family
NEH16_RS26740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NEH16_RS26750	COG0284	orotidine-5'-phosphate decarboxylase activity
NEH16_RS26765	COG1758	RNA polymerase activity
NEH16_RS26775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NEH16_RS26790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NEH16_RS26800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NEH16_RS26805	COG2390	Transcriptional regulator
NEH16_RS26810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEH16_RS26825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NEH16_RS26835	COG2233	PERMEase
NEH16_RS26840	COG2223	nitrite transmembrane transporter activity
NEH16_RS26845	COG1846	Transcriptional regulator
NEH16_RS26845	COG1940	carbohydrate kinase activity
NEH16_RS26865	COG3201	nicotinamide mononucleotide transporter
NEH16_RS26870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NEH16_RS26870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NEH16_RS26875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NEH16_RS26880	COG0140	phosphoribosyl-ATP diphosphatase activity
NEH16_RS26885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NEH16_RS26920	COG1063	alcohol dehydrogenase
NEH16_RS26955	COG1404	Belongs to the peptidase S8 family
NEH16_RS26980	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS26990	COG1522	sequence-specific DNA binding
NEH16_RS27000	COG1216	Glycosyl transferase, family 2
NEH16_RS27005	COG3030	protein affecting phage T7 exclusion by the F plasmid
NEH16_RS27015	COG2270	Major facilitator Superfamily
NEH16_RS27025	COG2364	Membrane
NEH16_RS27030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEH16_RS27085	COG2018	Roadblock/LC7 domain
NEH16_RS27105	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NEH16_RS27115	COG1501	Belongs to the glycosyl hydrolase 31 family
NEH16_RS27120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEH16_RS27130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEH16_RS27160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NEH16_RS27180	COG1716	ATPase activity
NEH16_RS27200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEH16_RS27210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NEH16_RS27210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NEH16_RS27295	COG1695	Transcriptional regulator
NEH16_RS27320	COG0697	spore germination
NEH16_RS27350	COG4214	carbohydrate transport
NEH16_RS27355	COG1129	ABC transporter
NEH16_RS27370	COG2160	L-arabinose isomerase activity
NEH16_RS27380	COG1609	Transcriptional regulator
NEH16_RS27395	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS27440	COG2188	Transcriptional regulator
NEH16_RS27470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NEH16_RS27500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NEH16_RS27515	COG1968	undecaprenyl-diphosphatase activity
NEH16_RS27525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NEH16_RS27570	COG1396	sequence-specific DNA binding
NEH16_RS27580	COG1832	CoA-binding protein
NEH16_RS27585	COG1739	Uncharacterized protein family UPF0029
NEH16_RS27590	COG0420	3'-5' exonuclease activity
NEH16_RS27600	COG1522	sequence-specific DNA binding
NEH16_RS27620	COG0626	cystathionine gamma-synthase activity
NEH16_RS27650	COG2188	Transcriptional regulator
NEH16_RS27655	COG1940	carbohydrate kinase activity
NEH16_RS27670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NEH16_RS27705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NEH16_RS27715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NEH16_RS27720	COG0156	8-amino-7-oxononanoate synthase activity
NEH16_RS27750	COG0740	serine-type endopeptidase activity
NEH16_RS27765	COG1309	transcriptional regulator
NEH16_RS27775	COG0204	Acyl-transferase
NEH16_RS27785	COG5297	Belongs to the glycosyl hydrolase family 6
NEH16_RS27790	COG4733	cellulase activity
NEH16_RS27790	COG5297	Belongs to the glycosyl hydrolase family 6
NEH16_RS27815	COG0205	6-phosphofructokinase activity
NEH16_RS27820	COG3442	glutamine amidotransferase
NEH16_RS27830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NEH16_RS27840	COG2045	Belongs to the ComB family
NEH16_RS27845	COG0242	peptide deformylase activity
NEH16_RS27855	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS27865	COG0386	Belongs to the glutathione peroxidase family
NEH16_RS27900	COG1946	Acyl-CoA thioesterase
NEH16_RS27915	COG1132	(ABC) transporter
NEH16_RS27930	COG0277	FAD linked oxidase domain protein
NEH16_RS27935	COG1846	Transcriptional regulator
NEH16_RS27940	COG1132	(ABC) transporter
NEH16_RS27950	COG2072	flavoprotein involved in K transport
NEH16_RS27965	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS28000	COG0454	-acetyltransferase
NEH16_RS28010	COG0475	glutathione-regulated potassium exporter activity
NEH16_RS28020	COG0367	asparagine synthase
NEH16_RS28065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NEH16_RS28135	COG2208	phosphoserine phosphatase activity
NEH16_RS28140	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NEH16_RS28150	COG0439	Biotin carboxylase
NEH16_RS28160	COG2186	Transcriptional regulator
NEH16_RS28190	COG3469	chitinase activity
NEH16_RS28200	COG2226	methyltransferase
NEH16_RS28210	COG3537	Alpha-1,2-mannosidase
NEH16_RS28220	COG1535	isochorismatase
NEH16_RS28220	COG3433	isochorismatase activity
NEH16_RS28225	COG1021	2,3-dihydroxybenzoate-AMP ligase
NEH16_RS28230	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS28250	COG0477	Major facilitator Superfamily
NEH16_RS28255	COG1309	transcriptional regulator
NEH16_RS28295	COG0667	Aldo Keto reductase
NEH16_RS28300	COG0667	Aldo Keto reductase
NEH16_RS28305	COG0515	serine threonine protein kinase
NEH16_RS28305	COG2815	serine threonine protein kinase
NEH16_RS28325	COG2706	6-phosphogluconolactonase activity
NEH16_RS28340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NEH16_RS28350	COG1609	Transcriptional regulator
NEH16_RS28360	COG1175	transmembrane transport
NEH16_RS28395	COG1902	pentaerythritol trinitrate reductase activity
NEH16_RS28405	COG1609	Transcriptional regulator
NEH16_RS28425	COG1879	ABC-type sugar transport system periplasmic component
NEH16_RS28430	COG1129	ABC transporter
NEH16_RS28440	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEH16_RS28445	COG1609	Transcriptional regulator
NEH16_RS28455	COG0640	Transcriptional regulator
NEH16_RS28470	COG0671	phosphoesterase, PA-phosphatase related
NEH16_RS28490	COG0584	glycerophosphoryl diester phosphodiesterase
NEH16_RS28530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NEH16_RS28545	COG1940	carbohydrate kinase activity
NEH16_RS28550	COG3345	alpha-galactosidase
NEH16_RS28565	COG0395	ABC-type sugar transport system, permease component
NEH16_RS28580	COG1660	Displays ATPase and GTPase activities
NEH16_RS28595	COG0445	tRNA wobble uridine modification
NEH16_RS28620	COG2223	nitrite transmembrane transporter activity
NEH16_RS28625	COG1940	carbohydrate kinase activity
NEH16_RS28660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NEH16_RS28670	COG1349	DNA-binding transcription factor activity
NEH16_RS28740	COG1309	transcriptional regulator
NEH16_RS28745	COG0477	Major facilitator Superfamily
NEH16_RS28770	COG1169	isochorismate synthase
NEH16_RS28775	COG1535	isochorismatase
NEH16_RS28775	COG3433	isochorismatase activity
NEH16_RS28790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS28795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS28800	COG1120	ATPase activity
NEH16_RS28810	COG0477	Major facilitator Superfamily
NEH16_RS28820	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NEH16_RS28825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS28830	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS28835	COG1120	ATPase activity
NEH16_RS28845	COG1132	(ABC) transporter
NEH16_RS28855	COG1132	(ABC) transporter
NEH16_RS28860	COG2382	esterase
NEH16_RS28875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NEH16_RS28880	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NEH16_RS28915	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS28925	COG0328	RNA-DNA hybrid ribonuclease activity
NEH16_RS28940	COG0297	glycogen (starch) synthase activity
NEH16_RS28945	COG0489	protein tyrosine kinase activity
NEH16_RS28985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEH16_RS28990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NEH16_RS28995	COG0277	FAD linked oxidase domain protein
NEH16_RS29025	COG3401	FG-GAP repeat protein
NEH16_RS29065	COG1175	transmembrane transport
NEH16_RS29070	COG0395	ABC-type sugar transport system, permease component
NEH16_RS29075	COG0366	Alpha amylase catalytic
NEH16_RS29100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEH16_RS29125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEH16_RS29130	COG1120	ATPase activity
NEH16_RS29190	COG1461	Dihydroxyacetone kinase
NEH16_RS29215	COG0435	Glutathione S-transferase
NEH16_RS29220	COG2838	Isocitrate dehydrogenase
NEH16_RS29225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NEH16_RS29235	COG1252	NADH dehydrogenase
NEH16_RS29305	COG2080	2 iron, 2 sulfur cluster binding
NEH16_RS29310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NEH16_RS29315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NEH16_RS29330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NEH16_RS29345	COG2356	endonuclease I
NEH16_RS29355	COG2813	Specifically methylates the guanine in position
NEH16_RS29365	COG0477	Major facilitator Superfamily
NEH16_RS29370	COG1473	amidohydrolase
NEH16_RS29380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEH16_RS29395	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEH16_RS29410	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS29425	COG2159	amidohydrolase
NEH16_RS29430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NEH16_RS29440	COG0515	serine threonine protein kinase
NEH16_RS29440	COG2815	serine threonine protein kinase
NEH16_RS29445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEH16_RS29450	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS29460	COG0596	Alpha beta hydrolase
NEH16_RS29490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NEH16_RS29550	COG0254	rRNA binding
NEH16_RS29565	COG0702	epimerase
NEH16_RS29580	COG2318	DinB family
NEH16_RS29630	COG1595	DNA-templated transcription, initiation
NEH16_RS29650	COG2208	phosphoserine phosphatase activity
NEH16_RS29650	COG2770	Histidine kinase
NEH16_RS29665	COG1191	sigma factor activity
NEH16_RS29670	COG1302	Protein conserved in bacteria
NEH16_RS29730	COG0477	Major facilitator Superfamily
NEH16_RS29740	COG0723	plastoquinol--plastocyanin reductase activity
NEH16_RS29740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEH16_RS29800	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NEH16_RS29815	COG0667	Aldo Keto reductase
NEH16_RS29825	COG2249	NAD(P)H dehydrogenase (quinone) activity
NEH16_RS29830	COG0656	L-ascorbic acid biosynthetic process
NEH16_RS29835	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS29840	COG1733	regulation of RNA biosynthetic process
NEH16_RS29855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NEH16_RS29860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NEH16_RS29870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NEH16_RS29925	COG0366	Alpha amylase catalytic
NEH16_RS29935	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NEH16_RS29940	COG0395	ABC-type sugar transport system, permease component
NEH16_RS29945	COG1175	transmembrane transport
NEH16_RS29950	COG2182	Extracellular solute-binding protein
NEH16_RS29960	COG1309	transcriptional regulator
NEH16_RS29970	COG2376	Dihydroxyacetone kinase
NEH16_RS29975	COG2376	Dihydroxyacetone kinase
NEH16_RS29980	COG0477	Major facilitator Superfamily
NEH16_RS30010	COG0477	Major facilitator Superfamily
NEH16_RS30060	COG0583	DNA-binding transcription factor activity
NEH16_RS30070	COG0477	Major facilitator Superfamily
NEH16_RS30080	COG0745	RESPONSE REGULATOR receiver
NEH16_RS30105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS30110	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS30115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEH16_RS30135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEH16_RS30155	COG0745	RESPONSE REGULATOR receiver
NEH16_RS30160	COG0747	negative chemotaxis
NEH16_RS30170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS30195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NEH16_RS30220	COG2226	methyltransferase
NEH16_RS30225	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NEH16_RS30250	COG2770	Histidine kinase
NEH16_RS30250	COG2208	phosphoserine phosphatase activity
NEH16_RS30255	COG1414	Transcriptional regulator
NEH16_RS30260	COG3971	2-oxopent-4-enoate hydratase activity
NEH16_RS30265	COG4569	acetaldehyde dehydrogenase (acetylating) activity
NEH16_RS30270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEH16_RS30285	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
NEH16_RS30305	COG0477	Major facilitator Superfamily
NEH16_RS30310	COG2272	Belongs to the type-B carboxylesterase lipase family
NEH16_RS30340	COG0154	amidase activity
NEH16_RS30375	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS30530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEH16_RS30540	COG4533	DNA binding
NEH16_RS30545	COG0601	transmembrane transport
NEH16_RS30550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEH16_RS30555	COG0444	Belongs to the ABC transporter superfamily
NEH16_RS30600	COG3457	Alanine racemase
NEH16_RS30605	COG0626	cystathionine gamma-synthase activity
NEH16_RS30610	COG1735	metal-dependent hydrolase with the TIM-barrel fold
NEH16_RS30630	COG2188	Transcriptional regulator
NEH16_RS30650	COG3833	ABC-type maltose transport systems, permease component
NEH16_RS30655	COG3537	Alpha-1,2-mannosidase
NEH16_RS30660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NEH16_RS30675	COG1609	Transcriptional regulator
NEH16_RS30685	COG1175	transmembrane transport
NEH16_RS30690	COG0395	ABC-type sugar transport system, permease component
NEH16_RS30700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NEH16_RS30715	COG2723	6-phospho-beta-galactosidase activity
NEH16_RS30725	COG3684	Belongs to the aldolase LacD family
NEH16_RS30735	COG3395	kinase activity
NEH16_RS30740	COG0235	Class ii aldolase
NEH16_RS30745	COG0366	Alpha amylase catalytic
NEH16_RS30775	COG0395	ABC-type sugar transport system, permease component
NEH16_RS30780	COG1175	transmembrane transport
NEH16_RS30795	COG1082	Xylose isomerase domain protein TIM barrel
NEH16_RS30880	COG0596	Alpha beta hydrolase
NEH16_RS30905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NEH16_RS30920	COG0174	glutamine synthetase
NEH16_RS30925	COG1012	belongs to the aldehyde dehydrogenase family
NEH16_RS30945	COG2814	Major facilitator Superfamily
NEH16_RS30965	COG0583	DNA-binding transcription factor activity
NEH16_RS30990	COG2985	domain, Protein
NEH16_RS31050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NEH16_RS31060	COG0783	Belongs to the Dps family
NEH16_RS31070	COG1335	isochorismatase
NEH16_RS31085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEH16_RS31100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NEH16_RS31105	COG1335	isochorismatase
NEH16_RS31120	COG2814	Major facilitator Superfamily
NEH16_RS31125	COG0477	Major facilitator Superfamily
NEH16_RS31130	COG0640	Transcriptional regulator
NEH16_RS31135	COG0583	DNA-binding transcription factor activity
NEH16_RS31205	COG0477	Major facilitator Superfamily
NEH16_RS31215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NEH16_RS31325	COG1280	lysine exporter protein (LysE YggA)
NEH16_RS31330	COG0583	DNA-binding transcription factor activity
NEH16_RS31345	COG0477	Major facilitator Superfamily
NEH16_RS31350	COG0640	Transcriptional regulator
NEH16_RS31360	COG3547	Transposase (IS116 IS110 IS902 family)
NEH16_RS31385	COG1278	Cold shock
NEH16_RS31400	COG0604	alcohol dehydrogenase
NEH16_RS31400	COG1028	Short-chain dehydrogenase reductase Sdr
NEH16_RS31400	COG3321	synthase
NEH16_RS31460	COG1181	Belongs to the D-alanine--D-alanine ligase family
NEH16_RS31475	COG3795	YCII-related domain
NEH16_RS31480	COG1216	Glycosyl transferase, family 2
NEH16_RS31505	COG1013	pyruvate-flavodoxin oxidoreductase activity
NEH16_RS31515	COG4770	biotin carboxylase activity
NEH16_RS31520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEH16_RS31555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEH16_RS31580	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS31590	COG3629	intracellular signal transduction
NEH16_RS31590	COG3903	Transcriptional regulator
NEH16_RS31605	COG0596	Alpha beta hydrolase
NEH16_RS31620	COG0604	alcohol dehydrogenase
NEH16_RS31620	COG3321	synthase
NEH16_RS31620	COG0604	alcohol dehydrogenase
NEH16_RS31620	COG3321	synthase
NEH16_RS31625	COG3321	synthase
NEH16_RS31625	COG0604	alcohol dehydrogenase
NEH16_RS31645	COG3321	synthase
NEH16_RS31645	COG0604	alcohol dehydrogenase
NEH16_RS31685	COG2124	cytochrome p450
NEH16_RS31710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEH16_RS31730	COG0604	alcohol dehydrogenase
NEH16_RS31730	COG3321	synthase
NEH16_RS31765	COG1216	Glycosyl transferase, family 2
NEH16_RS31770	COG1132	(ABC) transporter
NEH16_RS31775	COG1132	(ABC) transporter
NEH16_RS31825	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS31830	COG2130	NADP-dependent
NEH16_RS31840	COG0596	Alpha beta hydrolase
NEH16_RS31990	COG0596	Alpha beta hydrolase
NEH16_RS32005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NEH16_RS32015	COG1819	glycosyl
NEH16_RS32020	COG0477	Major facilitator Superfamily
NEH16_RS32045	COG1819	glycosyl
NEH16_RS32055	COG3321	synthase
NEH16_RS32055	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NEH16_RS32055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NEH16_RS32080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEH16_RS32105	COG1309	transcriptional regulator
NEH16_RS32135	COG1595	DNA-templated transcription, initiation
NEH16_RS32165	COG0406	alpha-ribazole phosphatase activity
NEH16_RS32190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NEH16_RS32205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NEH16_RS32210	COG1309	transcriptional regulator
NEH16_RS32275	COG2132	Multicopper oxidase
NEH16_RS32295	COG0134	indole-3-glycerol-phosphate synthase activity
NEH16_RS32305	COG1960	acyl-CoA dehydrogenase activity
NEH16_RS32310	COG0662	Cupin 2, conserved barrel domain protein
NEH16_RS32315	COG0159	tryptophan synthase activity
NEH16_RS32320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NEH16_RS32330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NEH16_RS32340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEH16_RS32345	COG0156	8-amino-7-oxononanoate synthase activity
NEH16_RS32360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NEH16_RS32375	COG2072	flavoprotein involved in K transport
NEH16_RS32390	COG2267	carboxylic ester hydrolase activity
NEH16_RS32410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NEH16_RS32420	COG1410	methionine synthase
NEH16_RS32420	COG0646	methionine synthase
NEH16_RS32425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEH16_RS32430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NEH16_RS32465	COG0318	PFAM AMP-dependent synthetase and ligase
NEH16_RS32485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEH16_RS32490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEH16_RS32495	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NEH16_RS32505	COG3629	intracellular signal transduction
NEH16_RS32530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEH16_RS32585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEH16_RS32595	COG0702	epimerase
NEH16_RS32710	COG1660	Displays ATPase and GTPase activities
NEH16_RS32925	COG1475	DNA binding
NEH16_RS32985	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
NEH16_RS33375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NEH16_RS33375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NEH16_RS33405	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives