locus-tag	class	description
M4V62_RS00040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M4V62_RS00130	COG4974	Belongs to the 'phage' integrase family
M4V62_RS00200	COG0583	DNA-binding transcription factor activity
M4V62_RS00220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M4V62_RS00225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS00245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M4V62_RS00250	COG0352	thiamine-phosphate diphosphorylase activity
M4V62_RS00260	COG0352	thiamine-phosphate diphosphorylase activity
M4V62_RS00260	COG0351	phosphomethylpyrimidine kinase
M4V62_RS00260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M4V62_RS00285	COG3118	belongs to the thioredoxin family
M4V62_RS00310	COG0596	Alpha beta hydrolase
M4V62_RS00315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M4V62_RS00325	COG4221	oxidoreductase activity
M4V62_RS00335	COG0667	Aldo Keto reductase
M4V62_RS00345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS00365	COG0395	ABC-type sugar transport system, permease component
M4V62_RS00370	COG1175	transmembrane transport
M4V62_RS00385	COG1501	Belongs to the glycosyl hydrolase 31 family
M4V62_RS00390	COG0628	permease
M4V62_RS00405	COG0596	Alpha beta hydrolase
M4V62_RS00430	COG1191	sigma factor activity
M4V62_RS00475	COG4221	oxidoreductase activity
M4V62_RS00510	COG0604	alcohol dehydrogenase
M4V62_RS00530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M4V62_RS00535	COG5640	endopeptidase activity
M4V62_RS00550	COG2318	DinB family
M4V62_RS00555	COG0583	DNA-binding transcription factor activity
M4V62_RS00560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M4V62_RS00595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS00620	COG3321	synthase
M4V62_RS00620	COG0604	alcohol dehydrogenase
M4V62_RS00625	COG1408	metallophosphoesterase
M4V62_RS00660	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M4V62_RS00675	COG0604	alcohol dehydrogenase
M4V62_RS00675	COG3321	synthase
M4V62_RS00680	COG0604	alcohol dehydrogenase
M4V62_RS00680	COG0604	alcohol dehydrogenase
M4V62_RS00680	COG3321	synthase
M4V62_RS00680	COG3321	synthase
M4V62_RS00725	COG1834	amidinotransferase
M4V62_RS00750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS00805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS00810	COG0604	alcohol dehydrogenase
M4V62_RS00815	COG2226	methyltransferase
M4V62_RS00825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M4V62_RS00860	COG3250	beta-galactosidase activity
M4V62_RS00875	COG0583	DNA-binding transcription factor activity
M4V62_RS00885	COG0667	Aldo Keto reductase
M4V62_RS00940	COG3848	Pyruvate phosphate dikinase
M4V62_RS00940	COG0574	Belongs to the PEP-utilizing enzyme family
M4V62_RS00950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M4V62_RS00970	COG0778	Nitroreductase
M4V62_RS00980	COG1595	DNA-templated transcription, initiation
M4V62_RS00990	COG0154	amidase activity
M4V62_RS01005	COG1309	transcriptional regulator
M4V62_RS01020	COG1819	glycosyl
M4V62_RS01025	COG0488	(ABC) transporter
M4V62_RS01040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M4V62_RS01045	COG1090	epimerase
M4V62_RS01060	COG2201	protein-glutamate methylesterase activity
M4V62_RS01065	COG2318	DinB family
M4V62_RS01075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS01120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M4V62_RS01125	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS01135	COG3629	intracellular signal transduction
M4V62_RS01135	COG3903	Transcriptional regulator
M4V62_RS01155	COG3135	benzoate transporter
M4V62_RS01165	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS01180	COG1132	(ABC) transporter
M4V62_RS01190	COG0667	Aldo Keto reductase
M4V62_RS01205	COG1846	Transcriptional regulator
M4V62_RS01210	COG2409	Drug exporters of the RND superfamily
M4V62_RS01285	COG0477	Major facilitator Superfamily
M4V62_RS01300	COG1271	oxidase subunit
M4V62_RS01310	COG4988	ABC transporter
M4V62_RS01315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M4V62_RS01350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M4V62_RS01355	COG2326	polyphosphate kinase activity
M4V62_RS01405	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M4V62_RS01410	COG2271	Major facilitator Superfamily
M4V62_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS01420	COG0277	FAD linked oxidase domain protein
M4V62_RS01425	COG1070	Carbohydrate kinase
M4V62_RS01435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M4V62_RS01440	COG0242	peptide deformylase activity
M4V62_RS01460	COG3795	YCII-related domain
M4V62_RS01465	COG4941	Belongs to the sigma-70 factor family
M4V62_RS01485	COG2084	Dehydrogenase
M4V62_RS01490	COG3395	kinase activity
M4V62_RS01495	COG0235	Class ii aldolase
M4V62_RS01500	COG2271	Major facilitator Superfamily
M4V62_RS01505	COG3622	Belongs to the hyi family
M4V62_RS01510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M4V62_RS01515	COG2186	Transcriptional regulator
M4V62_RS01545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M4V62_RS01560	COG1309	transcriptional regulator
M4V62_RS01570	COG2318	DinB family
M4V62_RS01610	COG0657	acetylesterase activity
M4V62_RS01640	COG4977	sequence-specific DNA binding
M4V62_RS01660	COG0673	inositol 2-dehydrogenase activity
M4V62_RS01685	COG2890	protein-(glutamine-N5) methyltransferase activity
M4V62_RS01690	COG2318	DinB family
M4V62_RS01695	COG1021	2,3-dihydroxybenzoate-AMP ligase
M4V62_RS01735	COG1846	Transcriptional regulator
M4V62_RS01755	COG1733	regulation of RNA biosynthetic process
M4V62_RS01765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M4V62_RS01790	COG2197	response regulator
M4V62_RS01805	COG2755	lipolytic protein G-D-S-L family
M4V62_RS01805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M4V62_RS01830	COG2814	Major facilitator Superfamily
M4V62_RS01835	COG0277	FAD linked oxidase domain protein
M4V62_RS01840	COG0142	geranyltranstransferase activity
M4V62_RS01870	COG2223	nitrite transmembrane transporter activity
M4V62_RS01875	COG2207	Transcriptional regulator
M4V62_RS01890	COG4221	oxidoreductase activity
M4V62_RS01910	COG2212	antiporter activity
M4V62_RS01920	COG0651	ATP synthesis coupled electron transport
M4V62_RS01925	COG1006	Multisubunit Na H antiporter MnhC subunit
M4V62_RS01930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M4V62_RS01930	COG2111	Na H antiporter
M4V62_RS01950	COG0477	Major facilitator Superfamily
M4V62_RS01970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M4V62_RS01995	COG0730	response to heat
M4V62_RS02020	COG0406	alpha-ribazole phosphatase activity
M4V62_RS02030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M4V62_RS02050	COG1802	Transcriptional regulator
M4V62_RS02080	COG2353	YceI-like domain
M4V62_RS02090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M4V62_RS02110	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M4V62_RS02125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M4V62_RS02145	COG0488	(ABC) transporter
M4V62_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS02165	COG1309	transcriptional regulator
M4V62_RS02180	COG1595	DNA-templated transcription, initiation
M4V62_RS02185	COG0784	Response regulator, receiver
M4V62_RS02190	COG4251	negative regulation of phosphorylation
M4V62_RS02195	COG0745	RESPONSE REGULATOR receiver
M4V62_RS02200	COG2318	DinB family
M4V62_RS02205	COG1414	Transcriptional regulator
M4V62_RS02210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS02215	COG2610	gluconate transmembrane transporter activity
M4V62_RS02230	COG0477	Major facilitator Superfamily
M4V62_RS02245	COG0656	L-ascorbic acid biosynthetic process
M4V62_RS02255	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS02265	COG1309	transcriptional regulator
M4V62_RS02315	COG2080	2 iron, 2 sulfur cluster binding
M4V62_RS02320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M4V62_RS02325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4V62_RS02330	COG1796	DNA polymerase
M4V62_RS02330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M4V62_RS02385	COG0659	secondary active sulfate transmembrane transporter activity
M4V62_RS02405	COG0477	Major facilitator Superfamily
M4V62_RS02425	COG1120	ATPase activity
M4V62_RS02440	COG1295	ribonuclease BN
M4V62_RS02455	COG4977	sequence-specific DNA binding
M4V62_RS02500	COG0395	ABC-type sugar transport system, permease component
M4V62_RS02505	COG1175	transmembrane transport
M4V62_RS02515	COG1609	Transcriptional regulator
M4V62_RS02520	COG2249	NAD(P)H dehydrogenase (quinone) activity
M4V62_RS02530	COG1131	(ABC) transporter
M4V62_RS02540	COG2197	response regulator
M4V62_RS02580	COG4948	Mandelate Racemase Muconate Lactonizing
M4V62_RS02615	COG2267	carboxylic ester hydrolase activity
M4V62_RS02620	COG0069	glutamate synthase activity
M4V62_RS02645	COG0187	DNA topoisomerase II activity
M4V62_RS02665	COG1595	DNA-templated transcription, initiation
M4V62_RS02680	COG0583	DNA-binding transcription factor activity
M4V62_RS02690	COG2124	cytochrome p450
M4V62_RS02705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4V62_RS02720	COG0738	Major facilitator superfamily
M4V62_RS02730	COG2409	Drug exporters of the RND superfamily
M4V62_RS02740	COG0366	Alpha amylase catalytic
M4V62_RS02745	COG3833	ABC-type maltose transport systems, permease component
M4V62_RS02750	COG1175	transmembrane transport
M4V62_RS02795	COG0328	RNA-DNA hybrid ribonuclease activity
M4V62_RS02800	COG1309	transcriptional regulator
M4V62_RS02805	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS02850	COG1233	COG1233 Phytoene dehydrogenase and related
M4V62_RS02875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M4V62_RS02875	COG0519	Catalyzes the synthesis of GMP from XMP
M4V62_RS02885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS02895	COG1902	pentaerythritol trinitrate reductase activity
M4V62_RS02900	COG1733	regulation of RNA biosynthetic process
M4V62_RS02910	COG0662	Cupin 2, conserved barrel domain protein
M4V62_RS02920	COG0596	Alpha beta hydrolase
M4V62_RS02955	COG2124	cytochrome p450
M4V62_RS02970	COG0488	(ABC) transporter
M4V62_RS02980	COG3511	phospholipase C
M4V62_RS03010	COG2837	iron assimilation
M4V62_RS03070	COG0366	Alpha amylase catalytic
M4V62_RS03075	COG3833	ABC-type maltose transport systems, permease component
M4V62_RS03080	COG1175	transmembrane transport
M4V62_RS03085	COG2182	Extracellular solute-binding protein
M4V62_RS03090	COG1609	Transcriptional regulator
M4V62_RS03095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS03100	COG4989	oxidoreductase activity
M4V62_RS03125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS03145	COG0583	DNA-binding transcription factor activity
M4V62_RS03150	COG0667	Aldo Keto reductase
M4V62_RS03170	COG2192	nodulation
M4V62_RS03180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M4V62_RS03190	COG0300	oxidoreductase activity
M4V62_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS03190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS03190	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS03190	COG3321	synthase
M4V62_RS03215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M4V62_RS03260	COG0583	DNA-binding transcription factor activity
M4V62_RS03290	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M4V62_RS03300	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M4V62_RS03310	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M4V62_RS03320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS03325	COG2186	Transcriptional regulator
M4V62_RS03345	COG1191	sigma factor activity
M4V62_RS03380	COG0596	Alpha beta hydrolase
M4V62_RS03410	COG0667	Aldo Keto reductase
M4V62_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS03440	COG1309	transcriptional regulator
M4V62_RS03445	COG0513	Belongs to the DEAD box helicase family
M4V62_RS03450	COG1278	Cold shock
M4V62_RS03455	COG1846	Transcriptional regulator
M4V62_RS03470	COG4213	ABC transporter substrate-binding protein
M4V62_RS03490	COG0583	DNA-binding transcription factor activity
M4V62_RS03580	COG2356	endonuclease I
M4V62_RS03585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M4V62_RS03605	COG4521	taurine ABC transporter
M4V62_RS03610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS03615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS03620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS03625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS03630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS03650	COG3590	peptidase
M4V62_RS03655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M4V62_RS03670	COG2409	Drug exporters of the RND superfamily
M4V62_RS03730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS03735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS03740	COG1120	ATPase activity
M4V62_RS03745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M4V62_RS03765	COG4264	IucA IucC family
M4V62_RS03785	COG4977	sequence-specific DNA binding
M4V62_RS03795	COG0330	HflC and HflK could
M4V62_RS03810	COG5492	domain, Protein
M4V62_RS03830	COG4941	Belongs to the sigma-70 factor family
M4V62_RS03840	COG0596	Alpha beta hydrolase
M4V62_RS03845	COG2175	clavaminate synthase activity
M4V62_RS03860	COG2409	Drug exporters of the RND superfamily
M4V62_RS03875	COG4941	Belongs to the sigma-70 factor family
M4V62_RS03890	COG0367	asparagine synthase
M4V62_RS03940	COG1335	isochorismatase
M4V62_RS03970	COG0546	phosphoglycolate phosphatase activity
M4V62_RS03990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M4V62_RS04005	COG4974	Belongs to the 'phage' integrase family
M4V62_RS04685	COG3617	BRO family, N-terminal domain
M4V62_RS04725	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS04735	COG0242	peptide deformylase activity
M4V62_RS04745	COG3442	glutamine amidotransferase
M4V62_RS04750	COG0205	6-phosphofructokinase activity
M4V62_RS04770	COG0204	Acyl-transferase
M4V62_RS04775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M4V62_RS04785	COG0829	nickel cation binding
M4V62_RS04790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M4V62_RS04795	COG0830	nickel cation binding
M4V62_RS04800	COG0804	urea catabolic process
M4V62_RS04805	COG0832	Belongs to the urease beta subunit family
M4V62_RS04810	COG0831	urea catabolic process
M4V62_RS04815	COG1309	transcriptional regulator
M4V62_RS04845	COG0248	Ppx GppA phosphatase
M4V62_RS04850	COG0693	protein deglycase activity
M4V62_RS04915	COG0740	serine-type endopeptidase activity
M4V62_RS04925	COG0791	NLP P60 protein
M4V62_RS04940	COG0583	DNA-binding transcription factor activity
M4V62_RS04960	COG0156	8-amino-7-oxononanoate synthase activity
M4V62_RS04965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M4V62_RS04970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M4V62_RS04975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M4V62_RS04980	COG2226	methyltransferase
M4V62_RS05005	COG0577	efflux transmembrane transporter activity
M4V62_RS05005	COG1136	(ABC) transporter
M4V62_RS05010	COG0577	efflux transmembrane transporter activity
M4V62_RS05010	COG1136	(ABC) transporter
M4V62_RS05045	COG0488	(ABC) transporter
M4V62_RS05055	COG0662	Cupin 2, conserved barrel domain protein
M4V62_RS05065	COG3594	Acyltransferase
M4V62_RS05095	COG3591	Belongs to the peptidase S1B family
M4V62_RS05135	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M4V62_RS05140	COG1733	regulation of RNA biosynthetic process
M4V62_RS05155	COG0747	negative chemotaxis
M4V62_RS05170	COG1122	ATPase activity
M4V62_RS05180	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
M4V62_RS05185	COG0310	cobalt ion transport
M4V62_RS05200	COG1024	Enoyl-CoA hydratase
M4V62_RS05205	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS05225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M4V62_RS05235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M4V62_RS05250	COG1846	Transcriptional regulator
M4V62_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS05265	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS05275	COG0477	Major facilitator Superfamily
M4V62_RS05315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M4V62_RS05350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M4V62_RS05355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M4V62_RS05360	COG0640	Transcriptional regulator
M4V62_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS05385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M4V62_RS05390	COG1609	Transcriptional regulator
M4V62_RS05415	COG3572	ergothioneine biosynthetic process
M4V62_RS05420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M4V62_RS05425	COG0121	glutamine amidotransferase
M4V62_RS05430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M4V62_RS05435	COG2182	Extracellular solute-binding protein
M4V62_RS05445	COG2188	Transcriptional regulator
M4V62_RS05480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS05495	COG1070	Carbohydrate kinase
M4V62_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS05525	COG0583	DNA-binding transcription factor activity
M4V62_RS05535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M4V62_RS05540	COG1053	succinate dehydrogenase
M4V62_RS05615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M4V62_RS05615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M4V62_RS05625	COG0531	amino acid
M4V62_RS05635	COG0395	ABC-type sugar transport system, permease component
M4V62_RS05640	COG4209	transmembrane transport
M4V62_RS05645	COG1940	carbohydrate kinase activity
M4V62_RS05645	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M4V62_RS05670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M4V62_RS05690	COG3618	amidohydrolase
M4V62_RS05695	COG3254	rhamnose metabolic process
M4V62_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS05710	COG4948	Mandelate Racemase Muconate Lactonizing
M4V62_RS05720	COG1129	ABC transporter
M4V62_RS05725	COG1879	ABC-type sugar transport system periplasmic component
M4V62_RS05730	COG2186	Transcriptional regulator
M4V62_RS05755	COG0395	ABC-type sugar transport system, permease component
M4V62_RS05760	COG1175	transmembrane transport
M4V62_RS05765	COG1653	transport
M4V62_RS05770	COG1609	Transcriptional regulator
M4V62_RS05790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M4V62_RS05810	COG1295	ribonuclease BN
M4V62_RS05835	COG3537	Alpha-1,2-mannosidase
M4V62_RS05840	COG0640	Transcriptional regulator
M4V62_RS05850	COG0655	NAD(P)H dehydrogenase (quinone) activity
M4V62_RS05865	COG1609	Transcriptional regulator
M4V62_RS05870	COG1879	ABC-type sugar transport system periplasmic component
M4V62_RS05875	COG1129	ABC transporter
M4V62_RS05880	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS05885	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS05890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M4V62_RS05895	COG0297	glycogen (starch) synthase activity
M4V62_RS05920	COG3458	cephalosporin-C deacetylase activity
M4V62_RS05925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M4V62_RS05950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M4V62_RS05965	COG1733	regulation of RNA biosynthetic process
M4V62_RS05995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M4V62_RS06000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS06005	COG0431	NADPH-dependent FMN reductase
M4V62_RS06010	COG0477	Major facilitator Superfamily
M4V62_RS06035	COG3311	Transcriptional regulator
M4V62_RS06040	COG1569	PIN domain
M4V62_RS06080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M4V62_RS06085	COG1518	maintenance of DNA repeat elements
M4V62_RS06125	COG1126	abc transporter atp-binding protein
M4V62_RS06130	COG0765	amino acid transport
M4V62_RS06135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4V62_RS06145	COG1228	amidohydrolase
M4V62_RS06160	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS06165	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS06190	COG1132	(ABC) transporter
M4V62_RS06195	COG1472	Belongs to the glycosyl hydrolase 3 family
M4V62_RS06205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4V62_RS06205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4V62_RS06210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M4V62_RS06235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M4V62_RS06265	COG2340	Cysteine-rich secretory protein family
M4V62_RS06275	COG4977	sequence-specific DNA binding
M4V62_RS06320	COG2197	response regulator
M4V62_RS06325	COG4585	Histidine kinase
M4V62_RS06355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M4V62_RS06360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M4V62_RS06370	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS06400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M4V62_RS06405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M4V62_RS06465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M4V62_RS06475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M4V62_RS06495	COG0367	asparagine synthase
M4V62_RS06530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M4V62_RS06545	COG4310	Domain of unknown function (DUF2172)
M4V62_RS06555	COG1216	Glycosyl transferase, family 2
M4V62_RS06555	COG0463	Glycosyl transferase, family 2
M4V62_RS06570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M4V62_RS06590	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M4V62_RS06615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M4V62_RS06625	COG2890	protein-(glutamine-N5) methyltransferase activity
M4V62_RS06640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M4V62_RS06665	COG0583	DNA-binding transcription factor activity
M4V62_RS06700	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS06705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M4V62_RS06750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M4V62_RS06755	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS06810	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS06815	COG0183	Belongs to the thiolase family
M4V62_RS06830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M4V62_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS06865	COG1309	transcriptional regulator
M4V62_RS06875	COG2340	Cysteine-rich secretory protein family
M4V62_RS06880	COG0673	inositol 2-dehydrogenase activity
M4V62_RS06890	COG0395	ABC-type sugar transport system, permease component
M4V62_RS06895	COG1175	transmembrane transport
M4V62_RS06910	COG2309	aminopeptidase activity
M4V62_RS06920	COG0477	Major facilitator Superfamily
M4V62_RS06945	COG1335	isochorismatase
M4V62_RS06950	COG0596	Alpha beta hydrolase
M4V62_RS06970	COG0668	transmembrane transport
M4V62_RS06980	COG1131	(ABC) transporter
M4V62_RS06995	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS07035	COG1609	Transcriptional regulator
M4V62_RS07055	COG0395	ABC-type sugar transport system, permease component
M4V62_RS07060	COG1175	transmembrane transport
M4V62_RS07085	COG2326	polyphosphate kinase activity
M4V62_RS07110	COG4044	May play a role in the intracellular transport of hydrophobic ligands
M4V62_RS07115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS07120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS07125	COG1120	ATPase activity
M4V62_RS07130	COG1132	(ABC) transporter
M4V62_RS07135	COG1132	(ABC) transporter
M4V62_RS07165	COG2186	Transcriptional regulator
M4V62_RS07175	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS07180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M4V62_RS07180	COG0825	malonyl-CoA metabolic process
M4V62_RS07185	COG0789	Transcriptional regulator
M4V62_RS07195	COG2205	protein histidine kinase activity
M4V62_RS07200	COG0745	RESPONSE REGULATOR receiver
M4V62_RS07270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M4V62_RS07275	COG1846	Transcriptional regulator
M4V62_RS07290	COG2391	methyltransferase activity
M4V62_RS07295	COG1309	transcriptional regulator
M4V62_RS07300	COG2814	Major facilitator Superfamily
M4V62_RS07305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M4V62_RS07325	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS07375	COG3959	Transketolase, thiamine diphosphate binding domain
M4V62_RS07380	COG3958	Transketolase
M4V62_RS07415	COG1396	sequence-specific DNA binding
M4V62_RS07420	COG1116	anion transmembrane transporter activity
M4V62_RS07430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS07440	COG1609	Transcriptional regulator
M4V62_RS07465	COG0583	DNA-binding transcription factor activity
M4V62_RS07470	COG0156	8-amino-7-oxononanoate synthase activity
M4V62_RS07475	COG1063	alcohol dehydrogenase
M4V62_RS07480	COG0673	inositol 2-dehydrogenase activity
M4V62_RS07495	COG1609	Transcriptional regulator
M4V62_RS07560	COG2755	lipolytic protein G-D-S-L family
M4V62_RS07570	COG2365	Tyrosine phosphatase family
M4V62_RS07590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M4V62_RS07595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M4V62_RS07610	COG1657	PFAM Prenyltransferase squalene oxidase
M4V62_RS07620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M4V62_RS07630	COG1562	ergosterol biosynthetic process
M4V62_RS07635	COG1134	teichoic acid transport
M4V62_RS07635	COG1388	LysM domain
M4V62_RS07685	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M4V62_RS07700	COG1024	Enoyl-CoA hydratase
M4V62_RS07710	COG4977	sequence-specific DNA binding
M4V62_RS07730	COG0488	(ABC) transporter
M4V62_RS07750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M4V62_RS07760	COG2936	dipeptidyl-peptidase activity
M4V62_RS07780	COG2267	carboxylic ester hydrolase activity
M4V62_RS07785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M4V62_RS07790	COG1113	amino acid transport
M4V62_RS07800	COG0789	Transcriptional regulator
M4V62_RS07810	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS07810	COG1024	Enoyl-CoA hydratase
M4V62_RS07815	COG0183	Belongs to the thiolase family
M4V62_RS07820	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS07825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS07830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M4V62_RS07845	COG3268	Saccharopine dehydrogenase
M4V62_RS07850	COG1515	deoxyribonuclease V activity
M4V62_RS07875	COG0488	(ABC) transporter
M4V62_RS07880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M4V62_RS07885	COG1834	amidinotransferase
M4V62_RS07985	COG1793	dna ligase
M4V62_RS07985	COG3285	dna ligase
M4V62_RS08080	COG1793	dna ligase
M4V62_RS08085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS08095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS08115	COG1846	Transcriptional regulator
M4V62_RS08135	COG3485	protocatechuate 3,4-dioxygenase
M4V62_RS08140	COG3485	protocatechuate 3,4-dioxygenase
M4V62_RS08145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M4V62_RS08150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS08155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4V62_RS08155	COG0515	serine threonine protein kinase
M4V62_RS08170	COG0659	secondary active sulfate transmembrane transporter activity
M4V62_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS08185	COG1024	Enoyl-CoA hydratase
M4V62_RS08210	COG0183	Belongs to the thiolase family
M4V62_RS08215	COG1309	transcriptional regulator
M4V62_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS08225	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS08230	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS08240	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M4V62_RS08270	COG0525	valine-tRNA ligase activity
M4V62_RS08275	COG3511	phospholipase C
M4V62_RS08285	COG3973	AAA domain
M4V62_RS08290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M4V62_RS08295	COG1309	transcriptional regulator
M4V62_RS08325	COG1486	melibiose metabolic process
M4V62_RS08335	COG0477	Major facilitator Superfamily
M4V62_RS08345	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS08350	COG3246	L-lysine catabolic process to acetate
M4V62_RS08355	COG1309	transcriptional regulator
M4V62_RS08375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M4V62_RS08380	COG1309	transcriptional regulator
M4V62_RS08390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M4V62_RS08395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M4V62_RS08400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS08415	COG0542	response to heat
M4V62_RS08435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS08440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS08445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M4V62_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS08455	COG1169	isochorismate synthase
M4V62_RS08460	COG1021	2,3-dihydroxybenzoate-AMP ligase
M4V62_RS08465	COG3433	isochorismatase activity
M4V62_RS08465	COG1535	isochorismatase
M4V62_RS08470	COG3433	isochorismatase activity
M4V62_RS08470	COG1535	isochorismatase
M4V62_RS08475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS08475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS08490	COG2382	esterase
M4V62_RS08500	COG2197	response regulator
M4V62_RS08505	COG4585	Histidine kinase
M4V62_RS08510	COG2409	Drug exporters of the RND superfamily
M4V62_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS08555	COG0045	succinate-CoA ligase (ADP-forming) activity
M4V62_RS08565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M4V62_RS08575	COG2223	nitrite transmembrane transporter activity
M4V62_RS08600	COG0084	hydrolase, TatD family'
M4V62_RS08650	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS08655	COG1129	ABC transporter
M4V62_RS08660	COG1940	carbohydrate kinase activity
M4V62_RS08670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4V62_RS08680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M4V62_RS08685	COG3383	formate dehydrogenase (NAD+) activity
M4V62_RS08690	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M4V62_RS08700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M4V62_RS08735	COG0477	Major facilitator Superfamily
M4V62_RS08765	COG3469	chitinase activity
M4V62_RS08785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M4V62_RS08825	COG2226	methyltransferase
M4V62_RS08830	COG2154	pterin-4-alpha-carbinolamine dehydratase
M4V62_RS08855	COG1140	nitrate reductase beta subunit
M4V62_RS08870	COG0443	Heat shock 70 kDa protein
M4V62_RS08890	COG0531	amino acid
M4V62_RS08940	COG0517	IMP dehydrogenase activity
M4V62_RS08955	COG0488	(ABC) transporter
M4V62_RS08965	COG2226	methyltransferase
M4V62_RS08980	COG3285	dna ligase
M4V62_RS08980	COG1793	dna ligase
M4V62_RS09010	COG1802	Transcriptional regulator
M4V62_RS09015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M4V62_RS09020	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS09050	COG1619	proteins homologs of microcin C7 resistance protein MccF
M4V62_RS09060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS09065	COG2362	D-Aminopeptidase
M4V62_RS09080	COG0583	DNA-binding transcription factor activity
M4V62_RS09090	COG1309	transcriptional regulator
M4V62_RS09110	COG2226	methyltransferase
M4V62_RS09115	COG2172	sigma factor antagonist activity
M4V62_RS09115	COG2208	phosphoserine phosphatase activity
M4V62_RS09115	COG1366	Belongs to the anti-sigma-factor antagonist family
M4V62_RS09155	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS09165	COG0604	alcohol dehydrogenase
M4V62_RS09170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS09170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS09185	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS09190	COG0688	phosphatidylethanolamine metabolic process
M4V62_RS09210	COG0559	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS09230	COG1929	Belongs to the glycerate kinase type-1 family
M4V62_RS09245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M4V62_RS09265	COG0483	inositol monophosphate 1-phosphatase activity
M4V62_RS09295	COG2235	arginine
M4V62_RS09305	COG0095	Lipoate-protein ligase
M4V62_RS09315	COG2197	response regulator
M4V62_RS09330	COG2226	methyltransferase
M4V62_RS09335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M4V62_RS09340	COG1316	TRANSCRIPTIONal
M4V62_RS09345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M4V62_RS09350	COG0640	Transcriptional regulator
M4V62_RS09355	COG1953	Uracil, thiamine, allantoin
M4V62_RS09370	COG2268	Band 7 protein
M4V62_RS09380	COG1595	DNA-templated transcription, initiation
M4V62_RS09385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS09395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS09400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M4V62_RS09405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M4V62_RS09425	COG3631	Ketosteroid isomerase-related protein
M4V62_RS09430	COG0702	epimerase
M4V62_RS09440	COG0405	Gamma-glutamyltransferase
M4V62_RS09450	COG1376	ErfK ybiS ycfS ynhG family protein
M4V62_RS09460	COG0765	amino acid transport
M4V62_RS09465	COG0765	amino acid transport
M4V62_RS09470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4V62_RS09475	COG1126	abc transporter atp-binding protein
M4V62_RS09495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M4V62_RS09500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M4V62_RS09525	COG3119	arylsulfatase activity
M4V62_RS09535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M4V62_RS09540	COG1472	Belongs to the glycosyl hydrolase 3 family
M4V62_RS09550	COG3226	Transcriptional regulator
M4V62_RS09690	COG2080	2 iron, 2 sulfur cluster binding
M4V62_RS09690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4V62_RS09695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M4V62_RS09735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS09745	COG1366	Belongs to the anti-sigma-factor antagonist family
M4V62_RS09750	COG1366	Belongs to the anti-sigma-factor antagonist family
M4V62_RS09755	COG2172	sigma factor antagonist activity
M4V62_RS09765	COG2208	phosphoserine phosphatase activity
M4V62_RS09765	COG2770	Histidine kinase
M4V62_RS09795	COG2423	ornithine cyclodeaminase activity
M4V62_RS09810	COG1940	carbohydrate kinase activity
M4V62_RS09820	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS09835	COG2188	Transcriptional regulator
M4V62_RS09840	COG0673	inositol 2-dehydrogenase activity
M4V62_RS09845	COG2197	response regulator
M4V62_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS09880	COG4266	Belongs to the allantoicase family
M4V62_RS09885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M4V62_RS09890	COG1414	Transcriptional regulator
M4V62_RS09895	COG2197	response regulator
M4V62_RS09900	COG4585	Histidine kinase
M4V62_RS09905	COG0577	efflux transmembrane transporter activity
M4V62_RS09920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS09930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M4V62_RS09935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M4V62_RS09945	COG2124	cytochrome p450
M4V62_RS09950	COG0300	oxidoreductase activity
M4V62_RS09975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M4V62_RS09980	COG0644	oxidoreductase
M4V62_RS10020	COG0436	Aminotransferase
M4V62_RS10045	COG0588	phosphoglycerate mutase activity
M4V62_RS10075	COG1733	regulation of RNA biosynthetic process
M4V62_RS10090	COG0534	Mate efflux family protein
M4V62_RS10105	COG2133	pyrroloquinoline quinone binding
M4V62_RS10105	COG5183	chlorophyll binding
M4V62_RS10130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M4V62_RS10135	COG0736	holo-[acyl-carrier-protein] synthase activity
M4V62_RS10140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M4V62_RS10150	COG2226	methyltransferase
M4V62_RS10180	COG1280	lysine exporter protein (LysE YggA)
M4V62_RS10200	COG2233	PERMEase
M4V62_RS10210	COG2233	PERMEase
M4V62_RS10220	COG2351	hydroxyisourate hydrolase activity
M4V62_RS10240	COG3622	Belongs to the hyi family
M4V62_RS10245	COG2084	Dehydrogenase
M4V62_RS10250	COG0753	catalase activity
M4V62_RS10260	COG3960	tartronate-semialdehyde synthase activity
M4V62_RS10265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4V62_RS10265	COG0515	serine threonine protein kinase
M4V62_RS10280	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS10300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M4V62_RS10305	COG2197	response regulator
M4V62_RS10320	COG0598	Magnesium transport protein CorA
M4V62_RS10345	COG0596	Alpha beta hydrolase
M4V62_RS10355	COG1316	TRANSCRIPTIONal
M4V62_RS10370	COG0668	transmembrane transport
M4V62_RS10385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M4V62_RS10405	COG1349	DNA-binding transcription factor activity
M4V62_RS10415	COG0076	glutamate decarboxylase activity
M4V62_RS10460	COG3938	Belongs to the proline racemase family
M4V62_RS10465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS10485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS10490	COG0006	proline dipeptidase activity
M4V62_RS10515	COG2252	PERMEase
M4V62_RS10520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4V62_RS10545	COG1802	Transcriptional regulator
M4V62_RS10570	COG0028	Belongs to the TPP enzyme family
M4V62_RS10580	COG1404	Belongs to the peptidase S8 family
M4V62_RS10610	COG1162	GTPase activity
M4V62_RS10655	COG2124	cytochrome p450
M4V62_RS10735	COG4977	sequence-specific DNA binding
M4V62_RS10735	COG1917	Cupin 2, conserved barrel domain protein
M4V62_RS10750	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS10775	COG0175	sulfate reduction
M4V62_RS10780	COG0529	Catalyzes the synthesis of activated sulfate
M4V62_RS10800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M4V62_RS10805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS10820	COG0519	Catalyzes the synthesis of GMP from XMP
M4V62_RS10825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M4V62_RS10845	COG2409	Drug exporters of the RND superfamily
M4V62_RS10870	COG2409	Drug exporters of the RND superfamily
M4V62_RS10880	COG2197	response regulator
M4V62_RS10965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M4V62_RS11000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M4V62_RS11005	COG0443	Heat shock 70 kDa protein
M4V62_RS11010	COG0443	Heat shock 70 kDa protein
M4V62_RS11065	COG1609	Transcriptional regulator
M4V62_RS11070	COG1129	ABC transporter
M4V62_RS11080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS11085	COG1869	D-ribose catabolic process
M4V62_RS11095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M4V62_RS11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS11115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M4V62_RS11125	COG1846	Transcriptional regulator
M4V62_RS11130	COG1764	response to oxidative stress
M4V62_RS11140	COG2234	aminopeptidase activity
M4V62_RS11140	COG4935	Belongs to the peptidase S8 family
M4V62_RS11150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M4V62_RS11150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M4V62_RS11165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M4V62_RS11170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M4V62_RS11205	COG0251	oxidation-reduction process
M4V62_RS11220	COG2271	Major facilitator Superfamily
M4V62_RS11225	COG1063	alcohol dehydrogenase
M4V62_RS11230	COG0246	Mannitol dehydrogenase
M4V62_RS11245	COG1609	Transcriptional regulator
M4V62_RS11255	COG2267	carboxylic ester hydrolase activity
M4V62_RS11275	COG0778	Nitroreductase
M4V62_RS11340	COG3220	belongs to the UPF0276 family
M4V62_RS11370	COG3253	May function as heme-dependent peroxidase
M4V62_RS11375	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M4V62_RS11385	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4V62_RS11390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M4V62_RS11405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M4V62_RS11410	COG0183	Belongs to the thiolase family
M4V62_RS11415	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS11415	COG1024	Enoyl-CoA hydratase
M4V62_RS11450	COG2843	Capsule synthesis protein
M4V62_RS11465	COG0531	amino acid
M4V62_RS11470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M4V62_RS11475	COG4214	carbohydrate transport
M4V62_RS11485	COG4213	ABC transporter substrate-binding protein
M4V62_RS11490	COG1940	carbohydrate kinase activity
M4V62_RS11495	COG0395	ABC-type sugar transport system, permease component
M4V62_RS11505	COG1653	transport
M4V62_RS11510	COG0395	ABC-type sugar transport system, permease component
M4V62_RS11515	COG1175	transmembrane transport
M4V62_RS11590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M4V62_RS11605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M4V62_RS11615	COG2267	carboxylic ester hydrolase activity
M4V62_RS11625	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS11645	COG1024	Enoyl-CoA hydratase
M4V62_RS11665	COG0531	amino acid
M4V62_RS11670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M4V62_RS11680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M4V62_RS11715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M4V62_RS11720	COG1799	cell septum assembly
M4V62_RS11725	COG2382	esterase
M4V62_RS11730	COG0596	Alpha beta hydrolase
M4V62_RS11740	COG3585	molybdate ion transport
M4V62_RS11785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M4V62_RS11800	COG1595	DNA-templated transcription, initiation
M4V62_RS11850	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS11855	COG2124	cytochrome p450
M4V62_RS11860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS11880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M4V62_RS11895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M4V62_RS11915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M4V62_RS11920	COG2175	clavaminate synthase activity
M4V62_RS11925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4V62_RS11930	COG4106	trans-aconitate 2-methyltransferase activity
M4V62_RS11990	COG3654	unkown
M4V62_RS12000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M4V62_RS12005	COG0531	amino acid
M4V62_RS12025	COG0569	domain protein
M4V62_RS12055	COG1136	(ABC) transporter
M4V62_RS12055	COG0577	efflux transmembrane transporter activity
M4V62_RS12065	COG1136	(ABC) transporter
M4V62_RS12080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M4V62_RS12085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M4V62_RS12090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M4V62_RS12105	COG0756	dUTP diphosphatase activity
M4V62_RS12130	COG2205	protein histidine kinase activity
M4V62_RS12135	COG0745	RESPONSE REGULATOR receiver
M4V62_RS12150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M4V62_RS12185	COG1435	thymidine kinase activity
M4V62_RS12205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4V62_RS12210	COG1802	Transcriptional regulator
M4V62_RS12225	COG0612	Peptidase, M16
M4V62_RS12230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M4V62_RS12250	COG0372	Belongs to the citrate synthase family
M4V62_RS12265	COG3290	protein histidine kinase activity
M4V62_RS12270	COG4565	transcriptional regulatory protein
M4V62_RS12275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4V62_RS12285	COG2197	response regulator
M4V62_RS12300	COG0187	DNA topoisomerase II activity
M4V62_RS12315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M4V62_RS12320	COG2186	Transcriptional regulator
M4V62_RS12360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M4V62_RS12405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M4V62_RS12410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M4V62_RS12415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M4V62_RS12455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M4V62_RS12465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M4V62_RS12470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M4V62_RS12480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M4V62_RS12500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M4V62_RS12510	COG2205	protein histidine kinase activity
M4V62_RS12515	COG0745	RESPONSE REGULATOR receiver
M4V62_RS12520	COG1126	abc transporter atp-binding protein
M4V62_RS12525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4V62_RS12530	COG0765	amino acid transport
M4V62_RS12535	COG0765	amino acid transport
M4V62_RS12570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M4V62_RS12580	COG0628	permease
M4V62_RS12620	COG1917	Cupin 2, conserved barrel domain protein
M4V62_RS12620	COG2207	Transcriptional regulator
M4V62_RS12625	COG1201	RNA secondary structure unwinding
M4V62_RS12630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M4V62_RS12635	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS12645	COG0783	Belongs to the Dps family
M4V62_RS12650	COG1396	sequence-specific DNA binding
M4V62_RS12655	COG1058	Belongs to the CinA family
M4V62_RS12655	COG1546	Belongs to the CinA family
M4V62_RS12665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M4V62_RS12675	COG1674	ftsk spoiiie
M4V62_RS12685	COG3437	response regulator, receiver
M4V62_RS12685	COG2205	protein histidine kinase activity
M4V62_RS12685	COG4999	Histidine kinase
M4V62_RS12685	COG3850	Histidine kinase
M4V62_RS12690	COG2208	phosphoserine phosphatase activity
M4V62_RS12690	COG2770	Histidine kinase
M4V62_RS12725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M4V62_RS12730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS12735	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M4V62_RS12755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M4V62_RS12760	COG0612	Peptidase, M16
M4V62_RS12765	COG1185	polyribonucleotide nucleotidyltransferase activity
M4V62_RS12770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M4V62_RS12785	COG0455	bacterial-type flagellum organization
M4V62_RS12795	COG0601	transmembrane transport
M4V62_RS12800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS12805	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS12810	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS12840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M4V62_RS12845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M4V62_RS12855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M4V62_RS12870	COG0779	Required for maturation of 30S ribosomal subunits
M4V62_RS12890	COG0442	prolyl-tRNA aminoacylation
M4V62_RS12905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M4V62_RS12910	COG0750	zinc metalloprotease
M4V62_RS12915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M4V62_RS12935	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS13030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS13035	COG1177	transmembrane transport
M4V62_RS13040	COG1176	ABC-type spermidine putrescine transport system, permease component I
M4V62_RS13045	COG3842	ATPase activity
M4V62_RS13070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4V62_RS13075	COG0584	glycerophosphoryl diester phosphodiesterase
M4V62_RS13085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M4V62_RS13105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M4V62_RS13110	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS13150	COG2986	histidine ammonia-lyase
M4V62_RS13160	COG1064	alcohol dehydrogenase
M4V62_RS13175	COG0477	Major facilitator Superfamily
M4V62_RS13190	COG1309	transcriptional regulator
M4V62_RS13205	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS13215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M4V62_RS13220	COG1136	(ABC) transporter
M4V62_RS13245	COG3842	ATPase activity
M4V62_RS13260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M4V62_RS13265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M4V62_RS13275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M4V62_RS13295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M4V62_RS13300	COG0575	Belongs to the CDS family
M4V62_RS13305	COG0233	cytoplasmic translational termination
M4V62_RS13310	COG0528	UMP kinase activity
M4V62_RS13315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M4V62_RS13320	COG0052	Belongs to the universal ribosomal protein uS2 family
M4V62_RS13335	COG1191	sigma factor activity
M4V62_RS13350	COG0792	nuclease activity
M4V62_RS13360	COG0494	nUDIX hydrolase
M4V62_RS13370	COG0681	Belongs to the peptidase S26 family
M4V62_RS13385	COG0335	large ribosomal subunit rRNA binding
M4V62_RS13390	COG0336	Belongs to the RNA methyltransferase TrmD family
M4V62_RS13395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M4V62_RS13400	COG1837	Belongs to the UPF0109 family
M4V62_RS13405	COG0228	four-way junction DNA binding
M4V62_RS13415	COG0442	prolyl-tRNA aminoacylation
M4V62_RS13435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M4V62_RS13445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M4V62_RS13475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M4V62_RS13485	COG0477	Major facilitator Superfamily
M4V62_RS13490	COG1196	nuclear chromosome segregation
M4V62_RS13500	COG1254	Belongs to the acylphosphatase family
M4V62_RS13505	COG2340	Cysteine-rich secretory protein family
M4V62_RS13510	COG1733	regulation of RNA biosynthetic process
M4V62_RS13515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M4V62_RS13520	COG0571	ribonuclease III activity
M4V62_RS13525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M4V62_RS13540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M4V62_RS13545	COG0742	ribosomal rna small subunit methyltransferase
M4V62_RS13555	COG1461	Dihydroxyacetone kinase
M4V62_RS13560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M4V62_RS13580	COG1181	Belongs to the D-alanine--D-alanine ligase family
M4V62_RS13585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M4V62_RS13595	COG1920	GTP binding
M4V62_RS13605	COG0776	regulation of translation
M4V62_RS13615	COG0066	3-isopropylmalate dehydratase activity
M4V62_RS13620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M4V62_RS13625	COG1414	Transcriptional regulator
M4V62_RS13670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M4V62_RS13675	COG0179	Fumarylacetoacetate (FAA) hydrolase
M4V62_RS13685	COG5002	protein histidine kinase activity
M4V62_RS13690	COG2018	Roadblock/LC7 domain
M4V62_RS13710	COG2018	Roadblock/LC7 domain
M4V62_RS13730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M4V62_RS13740	COG2353	YceI-like domain
M4V62_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS13775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M4V62_RS13795	COG2957	Belongs to the agmatine deiminase family
M4V62_RS13800	COG0804	urea catabolic process
M4V62_RS13805	COG0832	Belongs to the urease beta subunit family
M4V62_RS13805	COG0831	urea catabolic process
M4V62_RS13815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M4V62_RS13820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M4V62_RS13825	COG0473	3-isopropylmalate dehydrogenase activity
M4V62_RS13840	COG0583	DNA-binding transcription factor activity
M4V62_RS13845	COG2130	NADP-dependent
M4V62_RS13880	COG1902	pentaerythritol trinitrate reductase activity
M4V62_RS13895	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS13900	COG0506	proline dehydrogenase activity
M4V62_RS13905	COG3835	regulator
M4V62_RS13920	COG0477	Major facilitator Superfamily
M4V62_RS13925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M4V62_RS13930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M4V62_RS13935	COG0440	acetolactate synthase activity
M4V62_RS13945	COG5001	Diguanylate cyclase
M4V62_RS13955	COG0667	Aldo Keto reductase
M4V62_RS13960	COG2133	pyrroloquinoline quinone binding
M4V62_RS13970	COG1672	PFAM Archaeal ATPase
M4V62_RS13970	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M4V62_RS13985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS13990	COG2409	Drug exporters of the RND superfamily
M4V62_RS14000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M4V62_RS14005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M4V62_RS14015	COG0154	amidase activity
M4V62_RS14020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M4V62_RS14030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M4V62_RS14055	COG0482	sulfurtransferase activity
M4V62_RS14065	COG2124	cytochrome p450
M4V62_RS14090	COG0596	Alpha beta hydrolase
M4V62_RS14095	COG2378	regulation of single-species biofilm formation
M4V62_RS14100	COG0583	DNA-binding transcription factor activity
M4V62_RS14110	COG2855	membrane
M4V62_RS14120	COG2860	membrane
M4V62_RS14130	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS14135	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS14140	COG0601	transmembrane transport
M4V62_RS14170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M4V62_RS14175	COG0509	glycine decarboxylation via glycine cleavage system
M4V62_RS14180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M4V62_RS14185	COG1760	l-serine dehydratase
M4V62_RS14205	COG1119	ATPase activity
M4V62_RS14210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M4V62_RS14215	COG2186	Transcriptional regulator
M4V62_RS14260	COG3321	synthase
M4V62_RS14260	COG0604	alcohol dehydrogenase
M4V62_RS14265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M4V62_RS14290	COG1024	Enoyl-CoA hydratase
M4V62_RS14295	COG1376	ErfK ybiS ycfS ynhG family protein
M4V62_RS14320	COG2197	response regulator
M4V62_RS14325	COG4585	Histidine kinase
M4V62_RS14335	COG1131	(ABC) transporter
M4V62_RS14345	COG1132	(ABC) transporter
M4V62_RS14370	COG0058	SHG alpha-glucan phosphorylase activity
M4V62_RS14385	COG0366	Alpha amylase catalytic
M4V62_RS14395	COG3281	Trehalose synthase
M4V62_RS14400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M4V62_RS14410	COG3118	belongs to the thioredoxin family
M4V62_RS14425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M4V62_RS14430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M4V62_RS14440	COG2755	lipolytic protein G-D-S-L family
M4V62_RS14465	COG0477	Major facilitator Superfamily
M4V62_RS14475	COG1301	dicarboxylic acid transport
M4V62_RS14480	COG3290	protein histidine kinase activity
M4V62_RS14485	COG4565	transcriptional regulatory protein
M4V62_RS14495	COG1175	transmembrane transport
M4V62_RS14500	COG0395	ABC-type sugar transport system, permease component
M4V62_RS14530	COG3209	COG3209 Rhs family protein
M4V62_RS14545	COG0205	6-phosphofructokinase activity
M4V62_RS14550	COG0280	phosphate acetyltransferase
M4V62_RS14550	COG0857	belongs to the CobB CobQ family
M4V62_RS14555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M4V62_RS14595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M4V62_RS14615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS14615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS14655	COG1309	transcriptional regulator
M4V62_RS14700	COG2205	protein histidine kinase activity
M4V62_RS14705	COG0745	RESPONSE REGULATOR receiver
M4V62_RS14720	COG0183	Belongs to the thiolase family
M4V62_RS14780	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M4V62_RS14795	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS14800	COG1309	transcriptional regulator
M4V62_RS14825	COG4585	Histidine kinase
M4V62_RS14830	COG2197	response regulator
M4V62_RS14845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M4V62_RS14850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M4V62_RS14855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M4V62_RS14860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M4V62_RS14865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M4V62_RS14870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M4V62_RS14875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M4V62_RS14895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M4V62_RS14900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M4V62_RS14910	COG2890	protein-(glutamine-N5) methyltransferase activity
M4V62_RS14915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M4V62_RS14920	COG0254	rRNA binding
M4V62_RS14935	COG0083	homoserine kinase activity
M4V62_RS14940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M4V62_RS14945	COG0460	homoserine dehydrogenase
M4V62_RS14950	COG0019	diaminopimelate decarboxylase activity
M4V62_RS14955	COG0018	arginyl-trna synthetase
M4V62_RS14960	COG0745	RESPONSE REGULATOR receiver
M4V62_RS14980	COG2197	response regulator
M4V62_RS14985	COG3851	Histidine kinase
M4V62_RS15015	COG0254	rRNA binding
M4V62_RS15025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M4V62_RS15030	COG3285	dna ligase
M4V62_RS15030	COG1793	dna ligase
M4V62_RS15035	COG1793	dna ligase
M4V62_RS15065	COG2205	protein histidine kinase activity
M4V62_RS15095	COG1309	transcriptional regulator
M4V62_RS15105	COG0791	NLP P60 protein
M4V62_RS15105	COG3883	PFAM NLP P60 protein
M4V62_RS15130	COG5002	protein histidine kinase activity
M4V62_RS15135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M4V62_RS15150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M4V62_RS15165	COG0745	RESPONSE REGULATOR receiver
M4V62_RS15170	COG2205	protein histidine kinase activity
M4V62_RS15175	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4V62_RS15175	COG0567	Dehydrogenase, E1 component
M4V62_RS15225	COG0604	alcohol dehydrogenase
M4V62_RS15245	COG1126	abc transporter atp-binding protein
M4V62_RS15250	COG4106	trans-aconitate 2-methyltransferase activity
M4V62_RS15285	COG1595	DNA-templated transcription, initiation
M4V62_RS15295	COG1011	Hydrolase
M4V62_RS15330	COG0142	geranyltranstransferase activity
M4V62_RS15335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4V62_RS15365	COG2172	sigma factor antagonist activity
M4V62_RS15380	COG1597	lipid kinase activity
M4V62_RS15405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M4V62_RS15410	COG0363	glucosamine-6-phosphate deaminase activity
M4V62_RS15415	COG1472	Belongs to the glycosyl hydrolase 3 family
M4V62_RS15420	COG0395	ABC-type sugar transport system, permease component
M4V62_RS15425	COG1175	transmembrane transport
M4V62_RS15430	COG2182	Extracellular solute-binding protein
M4V62_RS15435	COG2188	Transcriptional regulator
M4V62_RS15440	COG1966	Carbon starvation protein
M4V62_RS15465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M4V62_RS15475	COG2124	cytochrome p450
M4V62_RS15485	COG0242	peptide deformylase activity
M4V62_RS15500	COG2199	diguanylate cyclase activity
M4V62_RS15500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M4V62_RS15505	COG5662	AntiSigma factor
M4V62_RS15510	COG1595	DNA-templated transcription, initiation
M4V62_RS15520	COG2135	peptidase activity
M4V62_RS15530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M4V62_RS15540	COG2076	Multidrug Resistance protein
M4V62_RS15550	COG0483	inositol monophosphate 1-phosphatase activity
M4V62_RS15560	COG0753	catalase activity
M4V62_RS15600	COG1615	UPF0182 protein
M4V62_RS15610	COG3480	Lon protease (S16) C-terminal proteolytic domain
M4V62_RS15665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M4V62_RS15705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS15710	COG0210	DNA helicase
M4V62_RS15775	COG0601	transmembrane transport
M4V62_RS15780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS15785	COG4166	transmembrane transport
M4V62_RS15825	COG0513	Belongs to the DEAD box helicase family
M4V62_RS15830	COG0596	Alpha beta hydrolase
M4V62_RS15835	COG1432	Conserved Protein
M4V62_RS15845	COG2095	MarC family integral membrane protein
M4V62_RS15860	COG2814	Major facilitator Superfamily
M4V62_RS15870	COG0598	Magnesium transport protein CorA
M4V62_RS15905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M4V62_RS15910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M4V62_RS15920	COG1595	DNA-templated transcription, initiation
M4V62_RS15935	COG1024	Enoyl-CoA hydratase
M4V62_RS15940	COG0519	Catalyzes the synthesis of GMP from XMP
M4V62_RS15950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M4V62_RS15955	COG1611	Belongs to the LOG family
M4V62_RS15960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS16020	COG2197	response regulator
M4V62_RS16025	COG4585	Histidine kinase
M4V62_RS16035	COG1131	(ABC) transporter
M4V62_RS16050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M4V62_RS16065	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS16070	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS16075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS16080	COG0601	transmembrane transport
M4V62_RS16095	COG1595	DNA-templated transcription, initiation
M4V62_RS16100	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS16105	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS16110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS16115	COG0601	transmembrane transport
M4V62_RS16125	COG1217	gtp-binding protein TYPA
M4V62_RS16145	COG1053	succinate dehydrogenase
M4V62_RS16150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M4V62_RS16180	COG2182	Extracellular solute-binding protein
M4V62_RS16185	COG1175	transmembrane transport
M4V62_RS16190	COG0395	ABC-type sugar transport system, permease component
M4V62_RS16195	COG2723	6-phospho-beta-galactosidase activity
M4V62_RS16210	COG1842	Phage shock protein A
M4V62_RS16270	COG3629	intracellular signal transduction
M4V62_RS16270	COG3903	Transcriptional regulator
M4V62_RS16300	COG1316	TRANSCRIPTIONal
M4V62_RS16325	COG0492	ferredoxin-NADP+ reductase activity
M4V62_RS16350	COG0297	glycogen (starch) synthase activity
M4V62_RS16360	COG0728	peptidoglycan biosynthetic process
M4V62_RS16370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M4V62_RS16375	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS16445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M4V62_RS16465	COG1140	nitrate reductase beta subunit
M4V62_RS16470	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M4V62_RS16480	COG0535	radical SAM domain protein
M4V62_RS16485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M4V62_RS16495	COG0012	GTP binding
M4V62_RS16510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M4V62_RS16515	COG0531	amino acid
M4V62_RS16520	COG1570	exodeoxyribonuclease VII activity
M4V62_RS16525	COG1722	exodeoxyribonuclease VII activity
M4V62_RS16530	COG0778	Nitroreductase
M4V62_RS16555	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M4V62_RS16555	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M4V62_RS16565	COG0114	fumarate hydratase activity
M4V62_RS16585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M4V62_RS16595	COG1136	(ABC) transporter
M4V62_RS16610	COG0450	alkyl hydroperoxide reductase
M4V62_RS16615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS16635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M4V62_RS16640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M4V62_RS16645	COG0667	Aldo Keto reductase
M4V62_RS16660	COG1733	regulation of RNA biosynthetic process
M4V62_RS16685	COG2885	chlorophyll binding
M4V62_RS16725	COG2894	cell division
M4V62_RS16760	COG2610	gluconate transmembrane transporter activity
M4V62_RS16765	COG0251	oxidation-reduction process
M4V62_RS16770	COG1414	Transcriptional regulator
M4V62_RS16785	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M4V62_RS16835	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M4V62_RS16845	COG0477	Major facilitator Superfamily
M4V62_RS16850	COG1309	transcriptional regulator
M4V62_RS16860	COG1331	Highly conserved protein containing a thioredoxin domain
M4V62_RS16875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M4V62_RS16885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M4V62_RS16900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M4V62_RS16905	COG2255	four-way junction helicase activity
M4V62_RS16910	COG1595	DNA-templated transcription, initiation
M4V62_RS16930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M4V62_RS16940	COG0789	Transcriptional regulator
M4V62_RS16955	COG1660	Displays ATPase and GTPase activities
M4V62_RS16960	COG0740	serine-type endopeptidase activity
M4V62_RS16965	COG0740	serine-type endopeptidase activity
M4V62_RS17000	COG1064	alcohol dehydrogenase
M4V62_RS17025	COG1136	(ABC) transporter
M4V62_RS17035	COG1376	ErfK ybiS ycfS ynhG family protein
M4V62_RS17060	COG2986	histidine ammonia-lyase
M4V62_RS17070	COG1024	Enoyl-CoA hydratase
M4V62_RS17075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M4V62_RS17085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M4V62_RS17095	COG0424	maF-like protein
M4V62_RS17105	COG4770	biotin carboxylase activity
M4V62_RS17135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4V62_RS17155	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS17190	COG1595	DNA-templated transcription, initiation
M4V62_RS17195	COG0745	RESPONSE REGULATOR receiver
M4V62_RS17200	COG2205	protein histidine kinase activity
M4V62_RS17225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4V62_RS17245	COG2814	Major facilitator Superfamily
M4V62_RS17250	COG0583	DNA-binding transcription factor activity
M4V62_RS17280	COG2188	Transcriptional regulator
M4V62_RS17305	COG1079	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS17310	COG4603	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS17315	COG3845	ABC transporter
M4V62_RS17320	COG1744	ABC transporter substrate-binding protein PnrA-like
M4V62_RS17325	COG1744	ABC transporter substrate-binding protein PnrA-like
M4V62_RS17330	COG1473	amidohydrolase
M4V62_RS17330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M4V62_RS17340	COG2089	acid synthase
M4V62_RS17355	COG1216	Glycosyl transferase, family 2
M4V62_RS17365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M4V62_RS17395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS17395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS17410	COG1595	DNA-templated transcription, initiation
M4V62_RS17420	COG1595	DNA-templated transcription, initiation
M4V62_RS17450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M4V62_RS17460	COG2009	succinate dehydrogenase
M4V62_RS17470	COG1053	succinate dehydrogenase
M4V62_RS17525	COG3386	PFAM SMP-30 Gluconolaconase
M4V62_RS17530	COG2409	Drug exporters of the RND superfamily
M4V62_RS17535	COG0745	RESPONSE REGULATOR receiver
M4V62_RS17540	COG2205	protein histidine kinase activity
M4V62_RS17550	COG1408	metallophosphoesterase
M4V62_RS17560	COG1686	Belongs to the peptidase S11 family
M4V62_RS17565	COG1295	ribonuclease BN
M4V62_RS17580	COG0671	phosphoesterase, PA-phosphatase related
M4V62_RS17600	COG0180	Tryptophanyl-tRNA synthetase
M4V62_RS17620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M4V62_RS17625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M4V62_RS17640	COG2130	NADP-dependent
M4V62_RS17655	COG0754	glutathionylspermidine amidase activity
M4V62_RS17670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS17675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS17680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS17685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M4V62_RS17695	COG4176	ABC-type proline glycine betaine transport system permease component
M4V62_RS17700	COG4175	Glycine betaine
M4V62_RS17700	COG0517	IMP dehydrogenase activity
M4V62_RS17710	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS17725	COG1476	TRANSCRIPTIONal
M4V62_RS17750	COG0039	L-malate dehydrogenase activity
M4V62_RS17765	COG2197	response regulator
M4V62_RS17770	COG4585	Histidine kinase
M4V62_RS17780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M4V62_RS17795	COG0515	serine threonine protein kinase
M4V62_RS17805	COG0138	bifunctional purine biosynthesis protein purh
M4V62_RS17835	COG0045	succinate-CoA ligase (ADP-forming) activity
M4V62_RS17850	COG3552	Protein containing von Willebrand factor type A (VWA) domain
M4V62_RS17855	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M4V62_RS17860	COG0714	Associated with various cellular activities
M4V62_RS17875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS17875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M4V62_RS17915	COG2197	response regulator
M4V62_RS17955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M4V62_RS17955	COG0519	Catalyzes the synthesis of GMP from XMP
M4V62_RS17985	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS17995	COG0515	serine threonine protein kinase
M4V62_RS18000	COG0515	serine threonine protein kinase
M4V62_RS18010	COG2815	serine threonine protein kinase
M4V62_RS18010	COG0515	serine threonine protein kinase
M4V62_RS18020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M4V62_RS18030	COG0516	GMP reductase activity
M4V62_RS18040	COG1595	DNA-templated transcription, initiation
M4V62_RS18045	COG2197	response regulator
M4V62_RS18055	COG0583	DNA-binding transcription factor activity
M4V62_RS18065	COG4221	oxidoreductase activity
M4V62_RS18070	COG0459	protein refolding
M4V62_RS18080	COG0726	polysaccharide deacetylase
M4V62_RS18090	COG4941	Belongs to the sigma-70 factor family
M4V62_RS18115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M4V62_RS18135	COG0802	atpase or kinase
M4V62_RS18145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M4V62_RS18160	COG0736	holo-[acyl-carrier-protein] synthase activity
M4V62_RS18165	COG1072	(Pantothenic acid kinase))
M4V62_RS18175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4V62_RS18180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M4V62_RS18185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M4V62_RS18200	COG0101	tRNA pseudouridine synthase activity
M4V62_RS18205	COG0203	ribosomal protein L17
M4V62_RS18210	COG0202	RNA polymerase activity
M4V62_RS18215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M4V62_RS18220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M4V62_RS18225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M4V62_RS18230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M4V62_RS18240	COG0563	adenylate kinase activity
M4V62_RS18250	COG0200	Binds to the 23S rRNA
M4V62_RS18255	COG1841	ribosomal large subunit assembly
M4V62_RS18260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M4V62_RS18265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M4V62_RS18270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M4V62_RS18275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M4V62_RS18280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M4V62_RS18285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M4V62_RS18290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M4V62_RS18295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M4V62_RS18300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M4V62_RS18305	COG0255	Belongs to the universal ribosomal protein uL29 family
M4V62_RS18310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M4V62_RS18315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M4V62_RS18320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M4V62_RS18325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M4V62_RS18330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M4V62_RS18335	COG0089	rRNA binding
M4V62_RS18340	COG0088	Forms part of the polypeptide exit tunnel
M4V62_RS18345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M4V62_RS18350	COG0051	transcription antitermination factor activity, RNA binding
M4V62_RS18355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M4V62_RS18360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M4V62_RS18365	COG0049	tRNA binding
M4V62_RS18370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M4V62_RS18385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M4V62_RS18390	COG0085	RNA polymerase activity
M4V62_RS18395	COG0222	ribosome binding
M4V62_RS18400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M4V62_RS18415	COG0081	regulation of translation
M4V62_RS18420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M4V62_RS18430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M4V62_RS18440	COG0436	Aminotransferase
M4V62_RS18445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4V62_RS18455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M4V62_RS18460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M4V62_RS18480	COG2030	dehydratase
M4V62_RS18485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M4V62_RS18500	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS18505	COG0702	epimerase
M4V62_RS18525	COG1666	GTP binding
M4V62_RS18530	COG2261	transglycosylase associated protein
M4V62_RS18535	COG3304	Inner membrane component domain
M4V62_RS18540	COG0501	Belongs to the peptidase M48B family
M4V62_RS18545	COG1007	ATP synthesis coupled electron transport
M4V62_RS18555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M4V62_RS18560	COG0713	ATP synthesis coupled electron transport
M4V62_RS18565	COG0839	Belongs to the complex I subunit 6 family
M4V62_RS18570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M4V62_RS18580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18610	COG0674	pyruvate-flavodoxin oxidoreductase activity
M4V62_RS18610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M4V62_RS18615	COG1013	pyruvate-flavodoxin oxidoreductase activity
M4V62_RS18620	COG1733	regulation of RNA biosynthetic process
M4V62_RS18625	COG0702	epimerase
M4V62_RS18635	COG0702	epimerase
M4V62_RS18655	COG0655	NAD(P)H dehydrogenase (quinone) activity
M4V62_RS18680	COG0142	geranyltranstransferase activity
M4V62_RS18685	COG3104	oligopeptide transport
M4V62_RS18695	COG0561	phosphatase activity
M4V62_RS18705	COG0492	ferredoxin-NADP+ reductase activity
M4V62_RS18715	COG0179	Fumarylacetoacetate (FAA) hydrolase
M4V62_RS18720	COG0514	ATP-dependent DNA helicase (RecQ)
M4V62_RS18725	COG1007	ATP synthesis coupled electron transport
M4V62_RS18735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M4V62_RS18740	COG0713	ATP synthesis coupled electron transport
M4V62_RS18745	COG0839	Belongs to the complex I subunit 6 family
M4V62_RS18750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M4V62_RS18760	COG1034	ATP synthesis coupled electron transport
M4V62_RS18765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M4V62_RS18775	COG0649	NAD binding
M4V62_RS18780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M4V62_RS18795	COG3103	Sh3 type 3 domain protein
M4V62_RS18795	COG1388	LysM domain
M4V62_RS18795	COG0791	NLP P60 protein
M4V62_RS18840	COG2226	methyltransferase
M4V62_RS18850	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M4V62_RS18940	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
M4V62_RS18960	COG5640	endopeptidase activity
M4V62_RS19115	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
M4V62_RS19120	COG1278	Cold shock
M4V62_RS19125	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS19135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS19140	COG0601	transmembrane transport
M4V62_RS19160	COG1396	sequence-specific DNA binding
M4V62_RS19180	COG1022	Amp-dependent synthetase and ligase
M4V62_RS19205	COG3708	Transcriptional regulator
M4V62_RS19205	COG2207	Transcriptional regulator
M4V62_RS19215	COG2161	toxin-antitoxin pair type II binding
M4V62_RS19245	COG0640	Transcriptional regulator
M4V62_RS19290	COG1309	transcriptional regulator
M4V62_RS19295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M4V62_RS19300	COG0798	PFAM Bile acid sodium symporter
M4V62_RS19305	COG0640	Transcriptional regulator
M4V62_RS19310	COG2226	methyltransferase
M4V62_RS19315	COG1301	dicarboxylic acid transport
M4V62_RS19330	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M4V62_RS19340	COG0163	prenyltransferase activity
M4V62_RS19345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M4V62_RS19350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M4V62_RS19360	COG0583	DNA-binding transcription factor activity
M4V62_RS19365	COG0697	spore germination
M4V62_RS19375	COG0640	Transcriptional regulator
M4V62_RS19395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M4V62_RS19410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M4V62_RS19420	COG0406	alpha-ribazole phosphatase activity
M4V62_RS19425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M4V62_RS19460	COG1742	UPF0060 membrane protein
M4V62_RS19480	COG1690	Belongs to the RtcB family
M4V62_RS19520	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M4V62_RS19525	COG0018	arginyl-trna synthetase
M4V62_RS19530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS19545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M4V62_RS19550	COG3321	synthase
M4V62_RS19550	COG0604	alcohol dehydrogenase
M4V62_RS19555	COG0113	porphobilinogen synthase activity
M4V62_RS19560	COG1648	precorrin-2 dehydrogenase activity
M4V62_RS19560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M4V62_RS19565	COG0181	hydroxymethylbilane synthase activity
M4V62_RS19570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M4V62_RS19575	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M4V62_RS19625	COG0123	including yeast histone deacetylase and acetoin utilization protein
M4V62_RS19640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4V62_RS19660	COG0180	Tryptophanyl-tRNA synthetase
M4V62_RS19665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M4V62_RS19675	COG0842	Transport permease protein
M4V62_RS19675	COG1129	ABC transporter
M4V62_RS19695	COG4991	sh3 domain protein
M4V62_RS19705	COG0129	dihydroxy-acid dehydratase activity
M4V62_RS19715	COG1082	Xylose isomerase domain protein TIM barrel
M4V62_RS19720	COG0248	Ppx GppA phosphatase
M4V62_RS19740	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M4V62_RS19750	COG0671	phosphoesterase, PA-phosphatase related
M4V62_RS19760	COG4585	Histidine kinase
M4V62_RS19770	COG1595	DNA-templated transcription, initiation
M4V62_RS19780	COG0745	RESPONSE REGULATOR receiver
M4V62_RS19785	COG2205	protein histidine kinase activity
M4V62_RS19790	COG0477	Major facilitator Superfamily
M4V62_RS19800	COG0739	heme binding
M4V62_RS19825	COG3467	pyridoxamine 5'-phosphate
M4V62_RS19855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M4V62_RS19880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M4V62_RS19885	COG0157	Belongs to the NadC ModD family
M4V62_RS19890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M4V62_RS19895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M4V62_RS19920	COG2197	response regulator
M4V62_RS19935	COG0649	NAD binding
M4V62_RS19960	COG1174	glycine betaine transport
M4V62_RS19965	COG1174	glycine betaine transport
M4V62_RS19995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M4V62_RS20010	COG0302	gtp cyclohydrolase
M4V62_RS20025	COG0037	tRNA processing
M4V62_RS20035	COG2027	D-alanyl-D-alanine carboxypeptidase
M4V62_RS20040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M4V62_RS20060	COG0789	Transcriptional regulator
M4V62_RS20065	COG0076	glutamate decarboxylase activity
M4V62_RS20085	COG2318	DinB family
M4V62_RS20090	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS20110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M4V62_RS20120	COG0254	rRNA binding
M4V62_RS20125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M4V62_RS20130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M4V62_RS20135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M4V62_RS20145	COG1289	transmembrane transporter activity
M4V62_RS20155	COG1136	(ABC) transporter
M4V62_RS20160	COG0577	efflux transmembrane transporter activity
M4V62_RS20165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M4V62_RS20165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M4V62_RS20170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M4V62_RS20170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M4V62_RS20175	COG3903	Transcriptional regulator
M4V62_RS20175	COG3629	intracellular signal transduction
M4V62_RS20180	COG5002	protein histidine kinase activity
M4V62_RS20185	COG0745	RESPONSE REGULATOR receiver
M4V62_RS20260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M4V62_RS20265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M4V62_RS20270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M4V62_RS20270	COG1754	DNA topoisomerase type I activity
M4V62_RS20280	COG2890	protein-(glutamine-N5) methyltransferase activity
M4V62_RS20290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M4V62_RS20300	COG1366	Belongs to the anti-sigma-factor antagonist family
M4V62_RS20305	COG1111	helicase
M4V62_RS20305	COG1205	dead DEAH box helicase
M4V62_RS20370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M4V62_RS20375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M4V62_RS20385	COG2267	carboxylic ester hydrolase activity
M4V62_RS20405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M4V62_RS20415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M4V62_RS20425	COG0251	oxidation-reduction process
M4V62_RS20440	COG0003	Pfam Anion-transporting ATPase
M4V62_RS20460	COG1408	metallophosphoesterase
M4V62_RS20490	COG2188	Transcriptional regulator
M4V62_RS20535	COG4249	Peptidase C14 caspase catalytic subunit p20
M4V62_RS20535	COG2319	Wd-40 repeat
M4V62_RS20540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS20585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M4V62_RS20605	COG1595	DNA-templated transcription, initiation
M4V62_RS20620	COG1695	Transcriptional regulator
M4V62_RS20635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M4V62_RS20640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M4V62_RS20655	COG0463	Glycosyl transferase, family 2
M4V62_RS20660	COG1802	Transcriptional regulator
M4V62_RS20665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M4V62_RS20695	COG0693	protein deglycase activity
M4V62_RS20705	COG0515	serine threonine protein kinase
M4V62_RS20705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4V62_RS20710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M4V62_RS20715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M4V62_RS20730	COG1131	(ABC) transporter
M4V62_RS20735	COG3559	Exporter of polyketide antibiotics
M4V62_RS20745	COG2197	response regulator
M4V62_RS20750	COG2124	cytochrome p450
M4V62_RS20760	COG3844	kynureninase activity
M4V62_RS20775	COG0191	fructose-bisphosphate aldolase activity
M4V62_RS20780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M4V62_RS20795	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M4V62_RS20820	COG0542	response to heat
M4V62_RS20850	COG1131	(ABC) transporter
M4V62_RS20875	COG0789	Transcriptional regulator
M4V62_RS20880	COG0484	heat shock protein binding
M4V62_RS20885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M4V62_RS20890	COG0443	Heat shock 70 kDa protein
M4V62_RS20895	COG0247	lactate metabolic process
M4V62_RS20895	COG2181	nitrate reductase activity
M4V62_RS20940	COG0717	Belongs to the dCTP deaminase family
M4V62_RS21020	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M4V62_RS21030	COG0583	DNA-binding transcription factor activity
M4V62_RS21045	COG1289	transmembrane transporter activity
M4V62_RS21085	COG0583	DNA-binding transcription factor activity
M4V62_RS21105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M4V62_RS21115	COG1309	transcriptional regulator
M4V62_RS21120	COG2084	Dehydrogenase
M4V62_RS21135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M4V62_RS21150	COG1741	Belongs to the pirin family
M4V62_RS21160	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS21165	COG1362	aminopeptidase activity
M4V62_RS21190	COG2271	Major facilitator Superfamily
M4V62_RS21195	COG1802	Transcriptional regulator
M4V62_RS21205	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4V62_RS21210	COG0022	dehydrogenase e1 component
M4V62_RS21230	COG0515	serine threonine protein kinase
M4V62_RS21235	COG0515	serine threonine protein kinase
M4V62_RS21250	COG0604	alcohol dehydrogenase
M4V62_RS21255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M4V62_RS21270	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4V62_RS21285	COG1522	sequence-specific DNA binding
M4V62_RS21290	COG1309	transcriptional regulator
M4V62_RS21295	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS21320	COG3396	Phenylacetate-CoA oxygenase
M4V62_RS21325	COG3460	Phenylacetate-CoA oxygenase
M4V62_RS21330	COG3396	Phenylacetate-CoA oxygenase
M4V62_RS21335	COG2151	metal-sulfur cluster biosynthetic enzyme
M4V62_RS21340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M4V62_RS21370	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS21395	COG1215	transferase activity, transferring glycosyl groups
M4V62_RS21400	COG0475	glutathione-regulated potassium exporter activity
M4V62_RS21400	COG0569	domain protein
M4V62_RS21415	COG1716	ATPase activity
M4V62_RS21420	COG1716	ATPase activity
M4V62_RS21435	COG0768	penicillin binding
M4V62_RS21440	COG0515	serine threonine protein kinase
M4V62_RS21445	COG3764	Sortase (surface protein transpeptidase)
M4V62_RS21450	COG3764	Sortase (surface protein transpeptidase)
M4V62_RS21465	COG3764	Sortase (surface protein transpeptidase)
M4V62_RS21480	COG0705	Rhomboid family
M4V62_RS21535	COG0515	serine threonine protein kinase
M4V62_RS21570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M4V62_RS21580	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
M4V62_RS21585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M4V62_RS21590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M4V62_RS21595	COG0592	DNA-directed DNA polymerase activity
M4V62_RS21600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M4V62_RS21605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M4V62_RS21610	COG0594	ribonuclease P activity
M4V62_RS21615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M4V62_RS21620	COG0706	membrane insertase activity
M4V62_RS21630	COG0357	Ribosomal RNA small subunit methyltransferase G
M4V62_RS21635	COG1192	Involved in chromosome partitioning
M4V62_RS21650	COG3118	belongs to the thioredoxin family
M4V62_RS21655	COG0492	ferredoxin-NADP+ reductase activity
M4V62_RS21665	COG1595	DNA-templated transcription, initiation
M4V62_RS21685	COG0617	tRNA 3'-terminal CCA addition
M4V62_RS21710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M4V62_RS21735	COG0360	Binds together with S18 to 16S ribosomal RNA
M4V62_RS21740	COG0629	single-stranded DNA binding
M4V62_RS21745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M4V62_RS21750	COG0359	binds to the 23S rRNA
M4V62_RS21760	COG0305	Participates in initiation and elongation during chromosome replication
M4V62_RS21770	COG2226	methyltransferase
M4V62_RS21790	COG2814	Major facilitator Superfamily
M4V62_RS21830	COG0626	cystathionine gamma-synthase activity
M4V62_RS21835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M4V62_RS21840	COG1950	PFAM Membrane protein of
M4V62_RS21845	COG0662	Cupin 2, conserved barrel domain protein
M4V62_RS21870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M4V62_RS21885	COG1609	Transcriptional regulator
M4V62_RS21890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M4V62_RS21895	COG1271	oxidase subunit
M4V62_RS21900	COG1294	oxidase, subunit
M4V62_RS21905	COG4988	ABC transporter
M4V62_RS21915	COG1196	nuclear chromosome segregation
M4V62_RS21915	COG0739	heme binding
M4V62_RS21915	COG0741	lytic transglycosylase activity
M4V62_RS21920	COG0561	phosphatase activity
M4V62_RS21935	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
M4V62_RS21940	COG0789	Transcriptional regulator
M4V62_RS21960	COG1131	(ABC) transporter
M4V62_RS21980	COG0561	phosphatase activity
M4V62_RS21985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M4V62_RS21995	COG2837	iron assimilation
M4V62_RS22000	COG1276	copper resistance
M4V62_RS22010	COG1999	signal sequence binding
M4V62_RS22030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS22035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M4V62_RS22040	COG0006	proline dipeptidase activity
M4V62_RS22060	COG0653	protein targeting
M4V62_RS22075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M4V62_RS22105	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS22115	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS22135	COG1595	DNA-templated transcription, initiation
M4V62_RS22140	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS22145	COG0784	Response regulator, receiver
M4V62_RS22205	COG1595	DNA-templated transcription, initiation
M4V62_RS22230	COG0745	RESPONSE REGULATOR receiver
M4V62_RS22235	COG2205	protein histidine kinase activity
M4V62_RS22245	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M4V62_RS22250	COG0477	Major facilitator Superfamily
M4V62_RS22260	COG3467	pyridoxamine 5'-phosphate
M4V62_RS22270	COG0477	Major facilitator Superfamily
M4V62_RS22275	COG1846	Transcriptional regulator
M4V62_RS22290	COG1191	sigma factor activity
M4V62_RS22295	COG1191	sigma factor activity
M4V62_RS22330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M4V62_RS22345	COG0433	COG0433 Predicted ATPase
M4V62_RS22365	COG0488	(ABC) transporter
M4V62_RS22370	COG2268	Band 7 protein
M4V62_RS22385	COG0583	DNA-binding transcription factor activity
M4V62_RS22400	COG2755	lipolytic protein G-D-S-L family
M4V62_RS22405	COG3835	regulator
M4V62_RS22430	COG0151	Belongs to the GarS family
M4V62_RS22445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M4V62_RS22455	COG2197	response regulator
M4V62_RS22490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M4V62_RS22495	COG0047	phosphoribosylformylglycinamidine synthase activity
M4V62_RS22500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M4V62_RS22535	COG3119	arylsulfatase activity
M4V62_RS22545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M4V62_RS22580	COG1643	Atp-dependent helicase
M4V62_RS22590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M4V62_RS22590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M4V62_RS22595	COG0785	Cytochrome C biogenesis protein
M4V62_RS22635	COG0513	Belongs to the DEAD box helicase family
M4V62_RS22665	COG1196	nuclear chromosome segregation
M4V62_RS22665	COG0739	heme binding
M4V62_RS22665	COG0741	lytic transglycosylase activity
M4V62_RS22670	COG0667	Aldo Keto reductase
M4V62_RS22680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M4V62_RS22685	COG0579	oxidoreductase
M4V62_RS22715	COG1252	NADH dehydrogenase
M4V62_RS22730	COG1846	Transcriptional regulator
M4V62_RS22750	COG2197	response regulator
M4V62_RS22755	COG4585	Histidine kinase
M4V62_RS22765	COG1131	(ABC) transporter
M4V62_RS22810	COG3226	Transcriptional regulator
M4V62_RS22835	COG1196	nuclear chromosome segregation
M4V62_RS22835	COG0741	lytic transglycosylase activity
M4V62_RS22835	COG0739	heme binding
M4V62_RS22840	COG0671	phosphoesterase, PA-phosphatase related
M4V62_RS22845	COG0277	FAD linked oxidase domain protein
M4V62_RS22860	COG1937	Protein conserved in bacteria
M4V62_RS22870	COG0306	phosphate transporter
M4V62_RS22875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M4V62_RS22895	COG0406	alpha-ribazole phosphatase activity
M4V62_RS22895	COG0494	nUDIX hydrolase
M4V62_RS22905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M4V62_RS22915	COG1131	(ABC) transporter
M4V62_RS22920	COG1725	Transcriptional regulator
M4V62_RS22925	COG0456	acetyltransferase
M4V62_RS22930	COG0737	Belongs to the 5'-nucleotidase family
M4V62_RS22945	COG0745	RESPONSE REGULATOR receiver
M4V62_RS22955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M4V62_RS22960	COG1609	Transcriptional regulator
M4V62_RS22965	COG0745	RESPONSE REGULATOR receiver
M4V62_RS22990	COG2897	thiosulfate sulfurtransferase activity
M4V62_RS23010	COG3485	protocatechuate 3,4-dioxygenase
M4V62_RS23025	COG1490	D-aminoacyl-tRNA deacylase activity
M4V62_RS23045	COG1609	Transcriptional regulator
M4V62_RS23055	COG2188	Transcriptional regulator
M4V62_RS23070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS23115	COG0768	penicillin binding
M4V62_RS23120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M4V62_RS23135	COG0346	lactoylglutathione lyase activity
M4V62_RS23155	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M4V62_RS23190	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS23215	COG0588	phosphoglycerate mutase activity
M4V62_RS23240	COG5002	protein histidine kinase activity
M4V62_RS23255	COG1329	Transcriptional regulator
M4V62_RS23260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M4V62_RS23265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M4V62_RS23270	COG3467	pyridoxamine 5'-phosphate
M4V62_RS23275	COG0215	cysteine-tRNA ligase activity
M4V62_RS23280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M4V62_RS23290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M4V62_RS23300	COG3842	ATPase activity
M4V62_RS23310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS23340	COG1053	succinate dehydrogenase
M4V62_RS23355	COG2197	response regulator
M4V62_RS23370	COG0666	response to abiotic stimulus
M4V62_RS23390	COG5564	TIM-barrel signal transduction protein
M4V62_RS23405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M4V62_RS23445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M4V62_RS23480	COG0463	Glycosyl transferase, family 2
M4V62_RS23500	COG0459	protein refolding
M4V62_RS23510	COG4115	mRNA cleavage
M4V62_RS23515	COG2161	toxin-antitoxin pair type II binding
M4V62_RS23575	COG1263	PTS System
M4V62_RS23575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4V62_RS23580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M4V62_RS23585	COG1737	Transcriptional regulator
M4V62_RS23610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS23650	COG3973	AAA domain
M4V62_RS23660	COG1061	Type III restriction enzyme res subunit
M4V62_RS23695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M4V62_RS23700	COG1120	ATPase activity
M4V62_RS23705	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS23710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS23730	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
M4V62_RS23735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M4V62_RS23745	COG2814	Major facilitator Superfamily
M4V62_RS23765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M4V62_RS23775	COG2252	PERMEase
M4V62_RS23790	COG0477	Major facilitator Superfamily
M4V62_RS23805	COG0667	Aldo Keto reductase
M4V62_RS23865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M4V62_RS23870	COG0247	lactate metabolic process
M4V62_RS23870	COG0277	FAD linked oxidase domain protein
M4V62_RS23905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M4V62_RS23935	COG0259	pyridoxamine-phosphate oxidase activity
M4V62_RS23950	COG4821	SIS domain
M4V62_RS23955	COG2205	protein histidine kinase activity
M4V62_RS23960	COG0745	RESPONSE REGULATOR receiver
M4V62_RS23975	COG0577	efflux transmembrane transporter activity
M4V62_RS23975	COG1136	(ABC) transporter
M4V62_RS23980	COG1136	(ABC) transporter
M4V62_RS23980	COG0577	efflux transmembrane transporter activity
M4V62_RS24040	COG1366	Belongs to the anti-sigma-factor antagonist family
M4V62_RS24050	COG1136	(ABC) transporter
M4V62_RS24065	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS24070	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS24075	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS24090	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS24120	COG1024	Enoyl-CoA hydratase
M4V62_RS24130	COG2072	flavoprotein involved in K transport
M4V62_RS24145	COG0259	pyridoxamine-phosphate oxidase activity
M4V62_RS24155	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS24165	COG1309	transcriptional regulator
M4V62_RS24170	COG0515	serine threonine protein kinase
M4V62_RS24170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M4V62_RS24175	COG1024	Enoyl-CoA hydratase
M4V62_RS24205	COG0587	DNA-directed DNA polymerase activity
M4V62_RS24210	COG0596	Alpha beta hydrolase
M4V62_RS24300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M4V62_RS24310	COG2365	Tyrosine phosphatase family
M4V62_RS24355	COG1686	Belongs to the peptidase S11 family
M4V62_RS24375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M4V62_RS24420	COG0477	Major facilitator Superfamily
M4V62_RS24435	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS24440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M4V62_RS24460	COG1846	Transcriptional regulator
M4V62_RS24465	COG3384	dioxygenase
M4V62_RS24475	COG1247	-acetyltransferase
M4V62_RS24490	COG0477	Major facilitator Superfamily
M4V62_RS24505	COG1420	regulation of RNA biosynthetic process
M4V62_RS24515	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M4V62_RS24515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4V62_RS24515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4V62_RS24530	COG1376	ErfK ybiS ycfS ynhG family protein
M4V62_RS24535	COG3191	aminopeptidase activity
M4V62_RS24545	COG2223	nitrite transmembrane transporter activity
M4V62_RS24550	COG1882	Formate acetyltransferase
M4V62_RS24555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M4V62_RS24565	COG1970	mechanosensitive ion channel activity
M4V62_RS24575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M4V62_RS24590	COG3263	regulation of cellular component size
M4V62_RS24595	COG2366	antibiotic biosynthetic process
M4V62_RS24600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M4V62_RS24605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M4V62_RS24615	COG0315	cyclic pyranopterin monophosphate synthase activity
M4V62_RS24620	COG0315	cyclic pyranopterin monophosphate synthase activity
M4V62_RS24620	COG0521	Mo-molybdopterin cofactor biosynthetic process
M4V62_RS24625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS24645	COG0708	Exodeoxyribonuclease III
M4V62_RS24660	COG2072	flavoprotein involved in K transport
M4V62_RS24665	COG2267	carboxylic ester hydrolase activity
M4V62_RS24670	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS24680	COG4946	Tricorn protease homolog
M4V62_RS24680	COG0793	Belongs to the peptidase S41A family
M4V62_RS24690	COG2409	Drug exporters of the RND superfamily
M4V62_RS24700	COG0310	cobalt ion transport
M4V62_RS24710	COG1122	ATPase activity
M4V62_RS24720	COG3209	COG3209 Rhs family protein
M4V62_RS24755	COG0442	prolyl-tRNA aminoacylation
M4V62_RS24785	COG0084	hydrolase, TatD family'
M4V62_RS24790	COG3583	domain protein
M4V62_RS24790	COG3584	3D domain protein
M4V62_RS24795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M4V62_RS24800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M4V62_RS24810	COG0488	(ABC) transporter
M4V62_RS24850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M4V62_RS24860	COG2197	response regulator
M4V62_RS24865	COG1846	Transcriptional regulator
M4V62_RS24870	COG4106	trans-aconitate 2-methyltransferase activity
M4V62_RS24895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M4V62_RS24905	COG0193	aminoacyl-tRNA hydrolase activity
M4V62_RS24910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M4V62_RS24915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M4V62_RS24920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M4V62_RS24935	COG4585	Histidine kinase
M4V62_RS24965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4V62_RS24975	COG0477	Major facilitator Superfamily
M4V62_RS24980	COG1136	(ABC) transporter
M4V62_RS24985	COG0577	efflux transmembrane transporter activity
M4V62_RS25055	COG2124	cytochrome p450
M4V62_RS25060	COG1652	LysM domain
M4V62_RS25070	COG0148	phosphopyruvate hydratase activity
M4V62_RS25095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M4V62_RS25100	COG0577	efflux transmembrane transporter activity
M4V62_RS25100	COG1136	(ABC) transporter
M4V62_RS25105	COG0577	efflux transmembrane transporter activity
M4V62_RS25105	COG1136	(ABC) transporter
M4V62_RS25115	COG1414	Transcriptional regulator
M4V62_RS25125	COG2814	Major facilitator Superfamily
M4V62_RS25150	COG0183	Belongs to the thiolase family
M4V62_RS25155	COG2755	lipolytic protein G-D-S-L family
M4V62_RS25170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M4V62_RS25180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M4V62_RS25195	COG1174	glycine betaine transport
M4V62_RS25220	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
M4V62_RS25240	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M4V62_RS25245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS25255	COG1228	amidohydrolase
M4V62_RS25270	COG1794	racemase activity, acting on amino acids and derivatives
M4V62_RS25275	COG1191	sigma factor activity
M4V62_RS25280	COG1366	Belongs to the anti-sigma-factor antagonist family
M4V62_RS25315	COG3104	oligopeptide transport
M4V62_RS25320	COG0745	RESPONSE REGULATOR receiver
M4V62_RS25325	COG2205	protein histidine kinase activity
M4V62_RS25340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M4V62_RS25350	COG0657	acetylesterase activity
M4V62_RS25400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M4V62_RS25425	COG1316	TRANSCRIPTIONal
M4V62_RS25450	COG1316	TRANSCRIPTIONal
M4V62_RS25455	COG1316	TRANSCRIPTIONal
M4V62_RS25470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M4V62_RS25480	COG0778	Nitroreductase
M4V62_RS25480	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
M4V62_RS25485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M4V62_RS25520	COG1620	l-lactate permease
M4V62_RS25525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M4V62_RS25530	COG2835	tetraacyldisaccharide 4'-kinase activity
M4V62_RS25540	COG1482	cell wall glycoprotein biosynthetic process
M4V62_RS25550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M4V62_RS25550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4V62_RS25550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M4V62_RS25555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M4V62_RS25595	COG0714	Associated with various cellular activities
M4V62_RS25615	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M4V62_RS25620	COG0745	RESPONSE REGULATOR receiver
M4V62_RS25625	COG5002	protein histidine kinase activity
M4V62_RS25630	COG0823	Involved in the tonB-independent uptake of proteins
M4V62_RS25640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M4V62_RS25645	COG2197	response regulator
M4V62_RS25650	COG3214	Protein conserved in bacteria
M4V62_RS25660	COG0653	protein targeting
M4V62_RS25690	COG2902	Dehydrogenase
M4V62_RS25695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M4V62_RS25700	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS25705	COG1134	teichoic acid transport
M4V62_RS25730	COG1216	Glycosyl transferase, family 2
M4V62_RS25740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M4V62_RS25745	COG0463	Glycosyl transferase, family 2
M4V62_RS25745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M4V62_RS25750	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS25790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M4V62_RS25795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M4V62_RS25800	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS25815	COG0395	ABC-type sugar transport system, permease component
M4V62_RS25820	COG1175	transmembrane transport
M4V62_RS25830	COG1674	ftsk spoiiie
M4V62_RS25835	COG0515	serine threonine protein kinase
M4V62_RS25840	COG0515	serine threonine protein kinase
M4V62_RS25845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M4V62_RS25860	COG2884	Cell division ATP-binding protein ftsE
M4V62_RS25870	COG0793	Belongs to the peptidase S41A family
M4V62_RS25875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M4V62_RS25895	COG2027	D-alanyl-D-alanine carboxypeptidase
M4V62_RS25905	COG0583	DNA-binding transcription factor activity
M4V62_RS25935	COG0697	spore germination
M4V62_RS25940	COG1846	Transcriptional regulator
M4V62_RS25995	COG3973	AAA domain
M4V62_RS26005	COG0776	regulation of translation
M4V62_RS26010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M4V62_RS26015	COG1678	Uncharacterized ACR, COG1678
M4V62_RS26075	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M4V62_RS26150	COG3480	Lon protease (S16) C-terminal proteolytic domain
M4V62_RS26170	COG1732	Glycine betaine
M4V62_RS26175	COG1174	glycine betaine transport
M4V62_RS26180	COG0517	IMP dehydrogenase activity
M4V62_RS26180	COG1125	glycine betaine transport
M4V62_RS26185	COG1174	glycine betaine transport
M4V62_RS26195	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M4V62_RS26215	COG0277	FAD linked oxidase domain protein
M4V62_RS26250	COG1335	isochorismatase
M4V62_RS26260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M4V62_RS26270	COG1113	amino acid transport
M4V62_RS26285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS26290	COG1120	ATPase activity
M4V62_RS26310	COG1234	tRNA 3'-trailer cleavage
M4V62_RS26320	COG1263	PTS System
M4V62_RS26325	COG1263	PTS System
M4V62_RS26330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4V62_RS26335	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M4V62_RS26350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M4V62_RS26360	COG0477	Major facilitator Superfamily
M4V62_RS26385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M4V62_RS26400	COG4555	ABC transporter
M4V62_RS26415	COG2733	membrane
M4V62_RS26470	COG1074	ATP-dependent DNA helicase activity
M4V62_RS26500	COG0270	DNA (cytosine-5-)-methyltransferase activity
M4V62_RS26520	COG3764	Sortase (surface protein transpeptidase)
M4V62_RS26530	COG0706	membrane insertase activity
M4V62_RS26530	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
M4V62_RS26540	COG4702	Belongs to the UPF0303 family
M4V62_RS26545	COG0673	inositol 2-dehydrogenase activity
M4V62_RS26550	COG1846	Transcriptional regulator
M4V62_RS26550	COG1940	carbohydrate kinase activity
M4V62_RS26560	COG2188	Transcriptional regulator
M4V62_RS26565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS26645	COG2186	Transcriptional regulator
M4V62_RS26670	COG3397	chitin binding
M4V62_RS26680	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS26700	COG2409	Drug exporters of the RND superfamily
M4V62_RS26705	COG2197	response regulator
M4V62_RS26710	COG4585	Histidine kinase
M4V62_RS26720	COG4585	Histidine kinase
M4V62_RS26725	COG0586	Pfam SNARE associated Golgi protein
M4V62_RS26740	COG1126	abc transporter atp-binding protein
M4V62_RS26745	COG0765	amino acid transport
M4V62_RS26750	COG0765	amino acid transport
M4V62_RS26755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4V62_RS26765	COG0154	amidase activity
M4V62_RS26785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS26835	COG0588	phosphoglycerate mutase activity
M4V62_RS26860	COG0745	RESPONSE REGULATOR receiver
M4V62_RS26865	COG5002	protein histidine kinase activity
M4V62_RS26880	COG2985	domain, Protein
M4V62_RS26885	COG2985	domain, Protein
M4V62_RS26895	COG0395	ABC-type sugar transport system, permease component
M4V62_RS26920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M4V62_RS26925	COG4977	sequence-specific DNA binding
M4V62_RS26935	COG0589	response to stress
M4V62_RS26945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M4V62_RS26975	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M4V62_RS26980	COG0076	glutamate decarboxylase activity
M4V62_RS26990	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS27005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M4V62_RS27010	COG1309	transcriptional regulator
M4V62_RS27020	COG1946	Acyl-CoA thioesterase
M4V62_RS27040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4V62_RS27050	COG0028	Belongs to the TPP enzyme family
M4V62_RS27080	COG1472	Belongs to the glycosyl hydrolase 3 family
M4V62_RS27090	COG0697	spore germination
M4V62_RS27115	COG0673	inositol 2-dehydrogenase activity
M4V62_RS27135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M4V62_RS27170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS27180	COG3718	enzyme involved in inositol metabolism
M4V62_RS27185	COG3962	Belongs to the TPP enzyme family
M4V62_RS27215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M4V62_RS27220	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS27230	COG1309	transcriptional regulator
M4V62_RS27260	COG0629	single-stranded DNA binding
M4V62_RS27345	COG0577	efflux transmembrane transporter activity
M4V62_RS27345	COG1136	(ABC) transporter
M4V62_RS27360	COG2346	COG2346, Truncated hemoglobins
M4V62_RS27365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M4V62_RS27410	COG1486	melibiose metabolic process
M4V62_RS27415	COG0395	ABC-type sugar transport system, permease component
M4V62_RS27420	COG1175	transmembrane transport
M4V62_RS27430	COG1940	carbohydrate kinase activity
M4V62_RS27430	COG1846	Transcriptional regulator
M4V62_RS27440	COG0668	transmembrane transport
M4V62_RS27450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M4V62_RS27450	COG3291	Pkd domain containing protein
M4V62_RS27475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4V62_RS27505	COG0583	DNA-binding transcription factor activity
M4V62_RS27510	COG2814	Major facilitator Superfamily
M4V62_RS27575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M4V62_RS27585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M4V62_RS27590	COG1113	amino acid transport
M4V62_RS27595	COG1113	amino acid transport
M4V62_RS27600	COG1268	BioY protein
M4V62_RS27615	COG1113	amino acid transport
M4V62_RS27630	COG4552	Acetyltransferase involved in intracellular survival and related
M4V62_RS27640	COG0475	glutathione-regulated potassium exporter activity
M4V62_RS27645	COG1136	(ABC) transporter
M4V62_RS27660	COG3594	Acyltransferase
M4V62_RS27680	COG0544	peptidyl-prolyl cis-trans isomerase activity
M4V62_RS27685	COG0740	serine-type endopeptidase activity
M4V62_RS27690	COG0740	serine-type endopeptidase activity
M4V62_RS27695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M4V62_RS27715	COG0525	valine-tRNA ligase activity
M4V62_RS27725	COG4585	Histidine kinase
M4V62_RS27730	COG1077	Cell shape determining protein MreB Mrl
M4V62_RS27735	COG0285	dihydrofolate synthase activity
M4V62_RS27745	COG0105	UTP biosynthetic process
M4V62_RS27750	COG1077	Cell shape determining protein MreB Mrl
M4V62_RS27770	COG0772	Belongs to the SEDS family
M4V62_RS27800	COG1530	ribonuclease E activity
M4V62_RS27810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M4V62_RS27815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M4V62_RS27820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M4V62_RS27830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M4V62_RS27840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M4V62_RS27855	COG0501	Belongs to the peptidase M48B family
M4V62_RS27870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M4V62_RS27880	COG0799	negative regulation of ribosome biogenesis
M4V62_RS27885	COG0588	phosphoglycerate mutase activity
M4V62_RS27900	COG0477	Major facilitator Superfamily
M4V62_RS27925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M4V62_RS27935	COG0495	leucyl-tRNA aminoacylation
M4V62_RS27945	COG1307	EDD domain protein, DegV family
M4V62_RS27950	COG1555	photosystem II stabilization
M4V62_RS27955	COG1234	tRNA 3'-trailer cleavage
M4V62_RS27975	COG0268	Binds directly to 16S ribosomal RNA
M4V62_RS27980	COG0481	GTPase activity
M4V62_RS27995	COG4999	Histidine kinase
M4V62_RS27995	COG2205	protein histidine kinase activity
M4V62_RS27995	COG3437	response regulator, receiver
M4V62_RS27995	COG3850	Histidine kinase
M4V62_RS28020	COG1420	regulation of RNA biosynthetic process
M4V62_RS28025	COG0484	heat shock protein binding
M4V62_RS28050	COG0793	Belongs to the peptidase S41A family
M4V62_RS28050	COG4946	Tricorn protease homolog
M4V62_RS28055	COG0537	adenosine 5'-monophosphoramidase activity
M4V62_RS28060	COG1234	tRNA 3'-trailer cleavage
M4V62_RS28065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M4V62_RS28075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS28085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M4V62_RS28095	COG2315	Protein conserved in bacteria
M4V62_RS28115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M4V62_RS28140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M4V62_RS28150	COG2409	Drug exporters of the RND superfamily
M4V62_RS28155	COG4585	Histidine kinase
M4V62_RS28165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS28170	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS28175	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS28185	COG0747	negative chemotaxis
M4V62_RS28190	COG2186	Transcriptional regulator
M4V62_RS28200	COG1396	sequence-specific DNA binding
M4V62_RS28235	COG1595	DNA-templated transcription, initiation
M4V62_RS28250	COG1381	Involved in DNA repair and RecF pathway recombination
M4V62_RS28255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M4V62_RS28265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M4V62_RS28275	COG0803	Belongs to the bacterial solute-binding protein 9 family
M4V62_RS28275	COG3443	Belongs to the bacterial solute-binding protein 9 family
M4V62_RS28280	COG0423	glycine-tRNA ligase activity
M4V62_RS28310	COG0477	Major facilitator Superfamily
M4V62_RS28330	COG0174	glutamine synthetase
M4V62_RS28335	COG4689	acetoacetate decarboxylase
M4V62_RS28350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M4V62_RS28365	COG0179	Fumarylacetoacetate (FAA) hydrolase
M4V62_RS28385	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M4V62_RS28390	COG1940	carbohydrate kinase activity
M4V62_RS28390	COG1846	Transcriptional regulator
M4V62_RS28395	COG0574	Belongs to the PEP-utilizing enzyme family
M4V62_RS28395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M4V62_RS28415	COG0745	RESPONSE REGULATOR receiver
M4V62_RS28440	COG0531	amino acid
M4V62_RS28450	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS28455	COG1309	transcriptional regulator
M4V62_RS28465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M4V62_RS28465	COG2146	nitrite reductase [NAD(P)H] activity
M4V62_RS28475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M4V62_RS28475	COG1017	nitric oxide dioxygenase activity
M4V62_RS28510	COG2205	protein histidine kinase activity
M4V62_RS28535	COG0243	molybdopterin cofactor binding
M4V62_RS28540	COG2949	membrane
M4V62_RS28550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M4V62_RS28560	COG0358	DNA primase activity
M4V62_RS28565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M4V62_RS28580	COG1070	Carbohydrate kinase
M4V62_RS28620	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS28650	COG1077	Cell shape determining protein MreB Mrl
M4V62_RS28655	COG0477	Major facilitator Superfamily
M4V62_RS28665	COG2255	four-way junction helicase activity
M4V62_RS28680	COG1404	Belongs to the peptidase S8 family
M4V62_RS28695	COG0515	serine threonine protein kinase
M4V62_RS28755	COG4981	capsule polysaccharide biosynthetic process
M4V62_RS28785	COG3386	PFAM SMP-30 Gluconolaconase
M4V62_RS28800	COG2130	NADP-dependent
M4V62_RS28805	COG1764	response to oxidative stress
M4V62_RS28855	COG1309	transcriptional regulator
M4V62_RS28880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M4V62_RS28885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M4V62_RS28890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4V62_RS28895	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M4V62_RS28905	COG1741	Belongs to the pirin family
M4V62_RS28920	COG0789	Transcriptional regulator
M4V62_RS28925	COG0667	Aldo Keto reductase
M4V62_RS28940	COG2197	response regulator
M4V62_RS28945	COG4585	Histidine kinase
M4V62_RS28960	COG1309	transcriptional regulator
M4V62_RS28965	COG0477	Major facilitator Superfamily
M4V62_RS28975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M4V62_RS28980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M4V62_RS29025	COG1358	cellular component organization or biogenesis
M4V62_RS29045	COG0800	Aldolase
M4V62_RS29155	COG1280	lysine exporter protein (LysE YggA)
M4V62_RS29175	COG4122	O-methyltransferase activity
M4V62_RS29185	COG0477	Major facilitator Superfamily
M4V62_RS29200	COG2124	cytochrome p450
M4V62_RS29205	COG0183	Belongs to the thiolase family
M4V62_RS29220	COG3845	ABC transporter
M4V62_RS29255	COG0515	serine threonine protein kinase
M4V62_RS29265	COG1132	(ABC) transporter
M4V62_RS29275	COG2197	response regulator
M4V62_RS29280	COG1309	transcriptional regulator
M4V62_RS29285	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS29310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS29320	COG2247	cell wall binding repeat
M4V62_RS29320	COG0860	N-Acetylmuramoyl-L-alanine amidase
M4V62_RS29340	COG0477	Major facilitator Superfamily
M4V62_RS29345	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS29350	COG0183	Belongs to the thiolase family
M4V62_RS29360	COG2197	response regulator
M4V62_RS29365	COG4585	Histidine kinase
M4V62_RS29375	COG1131	(ABC) transporter
M4V62_RS29380	COG2030	dehydratase
M4V62_RS29390	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS29400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M4V62_RS29405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M4V62_RS29420	COG0800	Aldolase
M4V62_RS29425	COG3022	response to hydroperoxide
M4V62_RS29480	COG1201	RNA secondary structure unwinding
M4V62_RS29485	COG2066	Belongs to the glutaminase family
M4V62_RS29500	COG1113	amino acid transport
M4V62_RS29505	COG2186	Transcriptional regulator
M4V62_RS29530	COG2259	Doxx family
M4V62_RS29540	COG0667	Aldo Keto reductase
M4V62_RS29555	COG3540	Alkaline phosphatase
M4V62_RS29565	COG2814	Major facilitator Superfamily
M4V62_RS29570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M4V62_RS29580	COG1834	amidinotransferase
M4V62_RS29610	COG0672	)-iron permease
M4V62_RS29615	COG2837	iron assimilation
M4V62_RS29625	COG1120	ATPase activity
M4V62_RS29630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS29635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M4V62_RS29650	COG0384	phenazine biosynthesis protein PhzF
M4V62_RS29695	COG1994	Peptidase M50
M4V62_RS29720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M4V62_RS29725	COG0477	Major facilitator Superfamily
M4V62_RS29740	COG2814	Major facilitator Superfamily
M4V62_RS29745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M4V62_RS29745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M4V62_RS29770	COG1609	Transcriptional regulator
M4V62_RS29780	COG0395	ABC-type sugar transport system, permease component
M4V62_RS29785	COG4209	transmembrane transport
M4V62_RS29790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M4V62_RS29805	COG0174	glutamine synthetase
M4V62_RS29855	COG0174	glutamine synthetase
M4V62_RS29870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M4V62_RS29895	COG1609	Transcriptional regulator
M4V62_RS29900	COG0366	Alpha amylase catalytic
M4V62_RS29920	COG1309	transcriptional regulator
M4V62_RS29955	COG2197	response regulator
M4V62_RS29960	COG4585	Histidine kinase
M4V62_RS29975	COG0745	RESPONSE REGULATOR receiver
M4V62_RS30000	COG2267	carboxylic ester hydrolase activity
M4V62_RS30030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS30035	COG1120	ATPase activity
M4V62_RS30080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M4V62_RS30085	COG0321	lipoyl(octanoyl) transferase activity
M4V62_RS30105	COG1090	epimerase
M4V62_RS30110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS30125	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS30130	COG4221	oxidoreductase activity
M4V62_RS30165	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4V62_RS30170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M4V62_RS30175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M4V62_RS30180	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M4V62_RS30195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M4V62_RS30195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M4V62_RS30200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M4V62_RS30220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M4V62_RS30225	COG2226	methyltransferase
M4V62_RS30245	COG4585	Histidine kinase
M4V62_RS30255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M4V62_RS30260	COG2814	Major facilitator Superfamily
M4V62_RS30270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M4V62_RS30290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS30300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M4V62_RS30305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M4V62_RS30315	COG1376	ErfK ybiS ycfS ynhG family protein
M4V62_RS30325	COG1845	cytochrome c oxidase, subunit III
M4V62_RS30330	COG2010	Cytochrome c
M4V62_RS30335	COG0723	plastoquinol--plastocyanin reductase activity
M4V62_RS30340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M4V62_RS30345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M4V62_RS30350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M4V62_RS30355	COG1929	Belongs to the glycerate kinase type-1 family
M4V62_RS30365	COG0745	RESPONSE REGULATOR receiver
M4V62_RS30370	COG2205	protein histidine kinase activity
M4V62_RS30420	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS30440	COG0003	Pfam Anion-transporting ATPase
M4V62_RS30450	COG1940	carbohydrate kinase activity
M4V62_RS30475	COG4585	Histidine kinase
M4V62_RS30480	COG2197	response regulator
M4V62_RS30485	COG0205	6-phosphofructokinase activity
M4V62_RS30490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M4V62_RS30510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M4V62_RS30515	COG0243	molybdopterin cofactor binding
M4V62_RS30520	COG2193	ferroxidase activity
M4V62_RS30525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M4V62_RS30535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M4V62_RS30540	COG2815	serine threonine protein kinase
M4V62_RS30540	COG0515	serine threonine protein kinase
M4V62_RS30545	COG2022	thiamine diphosphate biosynthetic process
M4V62_RS30555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS30555	COG2022	thiamine diphosphate biosynthetic process
M4V62_RS30570	COG0352	thiamine-phosphate diphosphorylase activity
M4V62_RS30585	COG1233	COG1233 Phytoene dehydrogenase and related
M4V62_RS30595	COG1309	transcriptional regulator
M4V62_RS30605	COG1126	abc transporter atp-binding protein
M4V62_RS30615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M4V62_RS30635	COG0714	Associated with various cellular activities
M4V62_RS30645	COG0275	rRNA processing
M4V62_RS30655	COG0768	penicillin binding
M4V62_RS30660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M4V62_RS30670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M4V62_RS30675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M4V62_RS30685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M4V62_RS30690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M4V62_RS30695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M4V62_RS30700	COG1496	oxidoreductase activity
M4V62_RS30710	COG1799	cell septum assembly
M4V62_RS30725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M4V62_RS30740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M4V62_RS30770	COG0515	serine threonine protein kinase
M4V62_RS30795	COG0587	DNA-directed DNA polymerase activity
M4V62_RS30805	COG1432	Conserved Protein
M4V62_RS30825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M4V62_RS30830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M4V62_RS30845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M4V62_RS30850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M4V62_RS30855	COG0131	Imidazoleglycerol-phosphate dehydratase
M4V62_RS30865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M4V62_RS30870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M4V62_RS30875	COG0251	oxidation-reduction process
M4V62_RS30880	COG0107	imidazoleglycerol-phosphate synthase activity
M4V62_RS30905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M4V62_RS30915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M4V62_RS30935	COG0134	indole-3-glycerol-phosphate synthase activity
M4V62_RS30940	COG0133	tryptophan synthase activity
M4V62_RS30945	COG0159	tryptophan synthase activity
M4V62_RS30955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M4V62_RS30965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M4V62_RS30970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS31000	COG0067	glutamate synthase
M4V62_RS31000	COG0069	glutamate synthase activity
M4V62_RS31000	COG0070	glutamate synthase
M4V62_RS31015	COG1175	transmembrane transport
M4V62_RS31020	COG0395	ABC-type sugar transport system, permease component
M4V62_RS31045	COG2304	oxidoreductase activity
M4V62_RS31050	COG2365	Tyrosine phosphatase family
M4V62_RS31055	COG1278	Cold shock
M4V62_RS31065	COG1357	PFAM Pentapeptide repeats (8 copies)
M4V62_RS31080	COG0366	Alpha amylase catalytic
M4V62_RS31080	COG1470	cell adhesion involved in biofilm formation
M4V62_RS31095	COG1605	Chorismate mutase
M4V62_RS31095	COG0287	Prephenate dehydrogenase
M4V62_RS31120	COG0737	Belongs to the 5'-nucleotidase family
M4V62_RS31135	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M4V62_RS31185	COG2050	protein possibly involved in aromatic compounds catabolism
M4V62_RS31220	COG1643	Atp-dependent helicase
M4V62_RS31225	COG2226	methyltransferase
M4V62_RS31245	COG0237	dephospho-CoA kinase activity
M4V62_RS31270	COG2226	methyltransferase
M4V62_RS31290	COG1288	antiporter activity
M4V62_RS31300	COG1802	Transcriptional regulator
M4V62_RS31305	COG1953	Uracil, thiamine, allantoin
M4V62_RS31345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M4V62_RS31425	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS31440	COG1132	(ABC) transporter
M4V62_RS31445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M4V62_RS31450	COG0022	dehydrogenase e1 component
M4V62_RS31455	COG0508	dehydrogenase complex catalyzes the overall conversion of
M4V62_RS31455	COG0596	Alpha beta hydrolase
M4V62_RS31510	COG0598	Magnesium transport protein CorA
M4V62_RS31515	COG2226	methyltransferase
M4V62_RS31525	COG2313	pseudouridylate synthase activity
M4V62_RS31540	COG2814	Major facilitator Superfamily
M4V62_RS31545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M4V62_RS31550	COG0584	glycerophosphoryl diester phosphodiesterase
M4V62_RS31560	COG0556	nucleotide-excision repair
M4V62_RS31585	COG0387	Pfam Sodium calcium exchanger
M4V62_RS31590	COG0477	Major facilitator Superfamily
M4V62_RS31595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M4V62_RS31610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M4V62_RS31615	COG1024	Enoyl-CoA hydratase
M4V62_RS31620	COG2353	YceI-like domain
M4V62_RS31630	COG1105	Belongs to the carbohydrate kinase PfkB family
M4V62_RS31635	COG0723	plastoquinol--plastocyanin reductase activity
M4V62_RS31655	COG0322	excinuclease ABC activity
M4V62_RS31660	COG1660	Displays ATPase and GTPase activities
M4V62_RS31665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M4V62_RS31670	COG1481	regulation of sporulation
M4V62_RS31680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M4V62_RS31685	COG0126	phosphoglycerate kinase activity
M4V62_RS31690	COG0149	triose-phosphate isomerase activity
M4V62_RS31695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M4V62_RS31705	COG0166	Belongs to the GPI family
M4V62_RS31710	COG0363	glucosamine-6-phosphate deaminase activity
M4V62_RS31725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M4V62_RS31735	COG0109	protoheme IX farnesyltransferase activity
M4V62_RS31760	COG1131	(ABC) transporter
M4V62_RS31765	COG2746	aminoglycoside 3-N-acetyltransferase activity
M4V62_RS31780	COG0719	Fe-S assembly protein
M4V62_RS31790	COG0396	ATPase activity
M4V62_RS31795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M4V62_RS31800	COG0822	iron-sulfur transferase activity
M4V62_RS31815	COG2076	Multidrug Resistance protein
M4V62_RS31820	COG3226	Transcriptional regulator
M4V62_RS31825	COG2171	N-acyltransferase activity
M4V62_RS31835	COG1595	DNA-templated transcription, initiation
M4V62_RS31845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS31935	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M4V62_RS31950	COG1063	alcohol dehydrogenase
M4V62_RS31955	COG0395	ABC-type sugar transport system, permease component
M4V62_RS31970	COG1349	DNA-binding transcription factor activity
M4V62_RS31975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M4V62_RS31980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS32015	COG1695	Transcriptional regulator
M4V62_RS32025	COG0768	penicillin binding
M4V62_RS32030	COG2197	response regulator
M4V62_RS32035	COG4585	Histidine kinase
M4V62_RS32050	COG1414	Transcriptional regulator
M4V62_RS32065	COG0477	Major facilitator Superfamily
M4V62_RS32085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M4V62_RS32100	COG1846	Transcriptional regulator
M4V62_RS32105	COG1902	pentaerythritol trinitrate reductase activity
M4V62_RS32110	COG5285	phytanoyl-CoA dioxygenase
M4V62_RS32115	COG1917	Cupin 2, conserved barrel domain protein
M4V62_RS32120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M4V62_RS32125	COG0456	acetyltransferase
M4V62_RS32130	COG2318	DinB family
M4V62_RS32135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M4V62_RS32155	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M4V62_RS32170	COG1797	cobyrinic acid a,c-diamide synthase activity
M4V62_RS32175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M4V62_RS32185	COG1492	cobalamin metabolic process
M4V62_RS32190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M4V62_RS32230	COG0235	Class ii aldolase
M4V62_RS32255	COG0488	(ABC) transporter
M4V62_RS32265	COG1024	Enoyl-CoA hydratase
M4V62_RS32365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M4V62_RS32375	COG1404	Belongs to the peptidase S8 family
M4V62_RS32390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4V62_RS32395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M4V62_RS32415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M4V62_RS32440	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS32445	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M4V62_RS32455	COG2186	Transcriptional regulator
M4V62_RS32475	COG0560	Phosphoserine phosphatase
M4V62_RS32475	COG3830	Belongs to the UPF0237 family
M4V62_RS32485	COG0842	Transport permease protein
M4V62_RS32485	COG1131	(ABC) transporter
M4V62_RS32485	COG1716	ATPase activity
M4V62_RS32495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M4V62_RS32510	COG2197	response regulator
M4V62_RS32525	COG1119	ATPase activity
M4V62_RS32545	COG1881	PFAM PEBP family protein
M4V62_RS32555	COG2094	Belongs to the DNA glycosylase MPG family
M4V62_RS32590	COG0647	UMP catabolic process
M4V62_RS32610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS32615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS32620	COG1120	ATPase activity
M4V62_RS32640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M4V62_RS32650	COG0497	DNA recombination
M4V62_RS32670	COG0531	amino acid
M4V62_RS32675	COG3387	PFAM Glycoside hydrolase 15-related
M4V62_RS32680	COG0504	CTP synthase activity
M4V62_RS32685	COG0494	nUDIX hydrolase
M4V62_RS32695	COG0686	Belongs to the AlaDH PNT family
M4V62_RS32710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M4V62_RS32715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M4V62_RS32720	COG1187	pseudouridine synthase activity
M4V62_RS32770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M4V62_RS32780	COG1160	GTP binding
M4V62_RS32795	COG1652	LysM domain
M4V62_RS32800	COG3583	domain protein
M4V62_RS32810	COG1137	ATPase activity
M4V62_RS32830	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS32855	COG0671	phosphoesterase, PA-phosphatase related
M4V62_RS32865	COG0477	Major facilitator Superfamily
M4V62_RS32870	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS32875	COG1799	cell septum assembly
M4V62_RS32885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4V62_RS32890	COG0765	amino acid transport
M4V62_RS32895	COG0765	amino acid transport
M4V62_RS32900	COG1126	abc transporter atp-binding protein
M4V62_RS32905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M4V62_RS32920	COG0330	HflC and HflK could
M4V62_RS32930	COG1454	alcohol dehydrogenase
M4V62_RS32930	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS32945	COG0587	DNA-directed DNA polymerase activity
M4V62_RS32960	COG1131	(ABC) transporter
M4V62_RS32965	COG4585	Histidine kinase
M4V62_RS32970	COG2197	response regulator
M4V62_RS32985	COG4565	transcriptional regulatory protein
M4V62_RS33015	COG2226	methyltransferase
M4V62_RS33030	COG1725	Transcriptional regulator
M4V62_RS33050	COG0726	polysaccharide deacetylase
M4V62_RS33055	COG1215	transferase activity, transferring glycosyl groups
M4V62_RS33060	COG0463	Glycosyl transferase, family 2
M4V62_RS33075	COG2755	lipolytic protein G-D-S-L family
M4V62_RS33100	COG1595	DNA-templated transcription, initiation
M4V62_RS33135	COG2197	response regulator
M4V62_RS33140	COG2197	response regulator
M4V62_RS33145	COG4585	Histidine kinase
M4V62_RS33185	COG2188	Transcriptional regulator
M4V62_RS33190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M4V62_RS33195	COG1309	transcriptional regulator
M4V62_RS33200	COG0243	molybdopterin cofactor binding
M4V62_RS33205	COG2851	Citrate transporter
M4V62_RS33240	COG0640	Transcriptional regulator
M4V62_RS33250	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS33270	COG0789	Transcriptional regulator
M4V62_RS33275	COG2233	PERMEase
M4V62_RS33285	COG1396	sequence-specific DNA binding
M4V62_RS33320	COG0477	Major facilitator Superfamily
M4V62_RS33330	COG3876	Protein conserved in bacteria
M4V62_RS33340	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS33345	COG1309	transcriptional regulator
M4V62_RS33375	COG2149	membrane
M4V62_RS33380	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M4V62_RS33400	COG3573	Dehydrogenase
M4V62_RS33430	COG3265	gluconokinase activity
M4V62_RS33435	COG2186	Transcriptional regulator
M4V62_RS33440	COG3012	SEC-C Motif Domain Protein
M4V62_RS33475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS33505	COG0667	Aldo Keto reductase
M4V62_RS33510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS33520	COG0598	Magnesium transport protein CorA
M4V62_RS33525	COG0406	alpha-ribazole phosphatase activity
M4V62_RS33540	COG0215	cysteine-tRNA ligase activity
M4V62_RS33545	COG5434	Belongs to the glycosyl hydrolase 28 family
M4V62_RS33555	COG1404	Belongs to the peptidase S8 family
M4V62_RS33555	COG4935	Belongs to the peptidase S8 family
M4V62_RS33565	COG2186	Transcriptional regulator
M4V62_RS33570	COG1846	Transcriptional regulator
M4V62_RS33595	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS33600	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS33625	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS33630	COG0477	Major facilitator Superfamily
M4V62_RS33640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M4V62_RS33645	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS33655	COG1079	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS33660	COG4603	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS33665	COG3845	ABC transporter
M4V62_RS33675	COG0235	Class ii aldolase
M4V62_RS33675	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M4V62_RS33680	COG0235	Class ii aldolase
M4V62_RS33685	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
M4V62_RS33690	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M4V62_RS33695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS33700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M4V62_RS33705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M4V62_RS33710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M4V62_RS33715	COG1414	Transcriptional regulator
M4V62_RS33720	COG0646	methionine synthase
M4V62_RS33720	COG1410	methionine synthase
M4V62_RS33730	COG4166	transmembrane transport
M4V62_RS33735	COG4166	transmembrane transport
M4V62_RS33740	COG2197	response regulator
M4V62_RS33750	COG0517	IMP dehydrogenase activity
M4V62_RS33750	COG1994	Peptidase M50
M4V62_RS33770	COG1222	aaa ATPase
M4V62_RS33775	COG4122	O-methyltransferase activity
M4V62_RS33790	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M4V62_RS33795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M4V62_RS33800	COG1609	Transcriptional regulator
M4V62_RS33810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M4V62_RS33845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M4V62_RS33850	COG0805	protein transport
M4V62_RS33865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS33910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M4V62_RS33915	COG0517	IMP dehydrogenase activity
M4V62_RS33915	COG4175	Glycine betaine
M4V62_RS33920	COG4176	ABC-type proline glycine betaine transport system permease component
M4V62_RS33955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M4V62_RS33960	COG0531	amino acid
M4V62_RS33970	COG0174	glutamine synthetase
M4V62_RS33975	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS33990	COG0560	Phosphoserine phosphatase
M4V62_RS33990	COG3830	Belongs to the UPF0237 family
M4V62_RS34025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M4V62_RS34030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M4V62_RS34035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M4V62_RS34040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M4V62_RS34045	COG5002	protein histidine kinase activity
M4V62_RS34050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M4V62_RS34055	COG0072	phenylalanine-tRNA ligase activity
M4V62_RS34055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M4V62_RS34085	COG1649	PFAM Uncharacterised BCR, COG1649
M4V62_RS34095	COG0697	spore germination
M4V62_RS34100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS34125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M4V62_RS34130	COG0667	Aldo Keto reductase
M4V62_RS34145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M4V62_RS34150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M4V62_RS34155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M4V62_RS34160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M4V62_RS34165	COG1438	arginine binding
M4V62_RS34170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS34180	COG1397	ADP-ribosylglycohydrolase
M4V62_RS34185	COG2188	Transcriptional regulator
M4V62_RS34190	COG0385	Bile acid
M4V62_RS34205	COG0165	Argininosuccinate lyase
M4V62_RS34220	COG0477	Major facilitator Superfamily
M4V62_RS34225	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS34225	COG0204	Acyl-transferase
M4V62_RS34230	COG0584	glycerophosphoryl diester phosphodiesterase
M4V62_RS34260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M4V62_RS34265	COG2011	ABC-type metal ion transport system permease component
M4V62_RS34270	COG1464	Belongs to the NlpA lipoprotein family
M4V62_RS34275	COG1464	Belongs to the NlpA lipoprotein family
M4V62_RS34290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M4V62_RS34295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M4V62_RS34295	COG1648	precorrin-2 dehydrogenase activity
M4V62_RS34320	COG3281	Trehalose synthase
M4V62_RS34355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M4V62_RS34425	COG5002	protein histidine kinase activity
M4V62_RS34425	COG2176	DNA-directed DNA polymerase activity
M4V62_RS34440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M4V62_RS34465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M4V62_RS34470	COG1560	Kdo2-lipid A biosynthetic process
M4V62_RS34475	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS34485	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M4V62_RS34490	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M4V62_RS34495	COG0217	transcriptional regulatory protein
M4V62_RS34500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M4V62_RS34505	COG0632	four-way junction helicase activity
M4V62_RS34510	COG2255	four-way junction helicase activity
M4V62_RS34520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4V62_RS34525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4V62_RS34530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M4V62_RS34535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M4V62_RS34540	COG1196	nuclear chromosome segregation
M4V62_RS34545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M4V62_RS34555	COG0124	histidyl-tRNA synthetase
M4V62_RS34575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M4V62_RS34595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M4V62_RS34600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M4V62_RS34605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M4V62_RS34610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M4V62_RS34615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M4V62_RS34620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M4V62_RS34625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M4V62_RS34635	COG0006	proline dipeptidase activity
M4V62_RS34640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M4V62_RS34645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M4V62_RS34655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M4V62_RS34660	COG0540	Belongs to the ATCase OTCase family
M4V62_RS34665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M4V62_RS34675	COG0505	Belongs to the CarA family
M4V62_RS34680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M4V62_RS34685	COG0167	dihydroorotate dehydrogenase activity
M4V62_RS34690	COG0284	orotidine-5'-phosphate decarboxylase activity
M4V62_RS34700	COG0194	GDP metabolic process
M4V62_RS34715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M4V62_RS34730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M4V62_RS34740	COG0667	Aldo Keto reductase
M4V62_RS34755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M4V62_RS34760	COG2390	Transcriptional regulator
M4V62_RS34785	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS34790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS34795	COG0531	amino acid
M4V62_RS34810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M4V62_RS34835	COG2233	PERMEase
M4V62_RS34840	COG0738	Major facilitator superfamily
M4V62_RS34845	COG1846	Transcriptional regulator
M4V62_RS34845	COG1940	carbohydrate kinase activity
M4V62_RS34860	COG3201	nicotinamide mononucleotide transporter
M4V62_RS34865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M4V62_RS34865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M4V62_RS34870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M4V62_RS34875	COG0140	phosphoribosyl-ATP diphosphatase activity
M4V62_RS34880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M4V62_RS34945	COG1309	transcriptional regulator
M4V62_RS34955	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS34990	COG0463	Glycosyl transferase, family 2
M4V62_RS35005	COG2270	Major facilitator Superfamily
M4V62_RS35020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS35050	COG0438	transferase activity, transferring glycosyl groups
M4V62_RS35055	COG2755	lipolytic protein G-D-S-L family
M4V62_RS35060	COG1984	allophanate hydrolase subunit 2
M4V62_RS35065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M4V62_RS35070	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M4V62_RS35080	COG2814	Major facilitator Superfamily
M4V62_RS35105	COG4638	Rieske (2fe-2S)
M4V62_RS35120	COG1414	Transcriptional regulator
M4V62_RS35130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M4V62_RS35165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M4V62_RS35170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M4V62_RS35175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4V62_RS35185	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M4V62_RS35200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M4V62_RS35210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M4V62_RS35240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M4V62_RS35280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M4V62_RS35290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M4V62_RS35290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M4V62_RS35320	COG0384	phenazine biosynthesis protein PhzF
M4V62_RS35330	COG1695	Transcriptional regulator
M4V62_RS35340	COG2890	protein-(glutamine-N5) methyltransferase activity
M4V62_RS35380	COG0697	spore germination
M4V62_RS35430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M4V62_RS35445	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M4V62_RS35465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4V62_RS35475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M4V62_RS35520	COG1968	undecaprenyl-diphosphatase activity
M4V62_RS35540	COG4948	Mandelate Racemase Muconate Lactonizing
M4V62_RS35565	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS35570	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS35575	COG0601	transmembrane transport
M4V62_RS35590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M4V62_RS35620	COG2272	Belongs to the type-B carboxylesterase lipase family
M4V62_RS35635	COG0110	maltose O-acetyltransferase activity
M4V62_RS35655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M4V62_RS35660	COG4585	Histidine kinase
M4V62_RS35735	COG1131	(ABC) transporter
M4V62_RS35745	COG1832	CoA-binding protein
M4V62_RS35775	COG1113	amino acid transport
M4V62_RS35790	COG1739	Uncharacterized protein family UPF0029
M4V62_RS35795	COG1716	ATPase activity
M4V62_RS35795	COG1131	(ABC) transporter
M4V62_RS35795	COG0842	Transport permease protein
M4V62_RS35820	COG0420	3'-5' exonuclease activity
M4V62_RS35825	COG0419	ATPase involved in DNA repair
M4V62_RS35830	COG1522	sequence-specific DNA binding
M4V62_RS35845	COG1522	sequence-specific DNA binding
M4V62_RS35850	COG0626	cystathionine gamma-synthase activity
M4V62_RS35865	COG0346	lactoylglutathione lyase activity
M4V62_RS35870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M4V62_RS35880	COG2267	carboxylic ester hydrolase activity
M4V62_RS35885	COG1595	DNA-templated transcription, initiation
M4V62_RS35890	COG2188	Transcriptional regulator
M4V62_RS35895	COG1940	carbohydrate kinase activity
M4V62_RS35900	COG2197	response regulator
M4V62_RS35905	COG4585	Histidine kinase
M4V62_RS35910	COG1131	(ABC) transporter
M4V62_RS35925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS35930	COG1024	Enoyl-CoA hydratase
M4V62_RS35965	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M4V62_RS35980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M4V62_RS36005	COG2364	Membrane
M4V62_RS36025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4V62_RS36035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M4V62_RS36050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4V62_RS36060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M4V62_RS36065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M4V62_RS36065	COG1263	PTS System
M4V62_RS36080	COG3387	PFAM Glycoside hydrolase 15-related
M4V62_RS36105	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M4V62_RS36110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M4V62_RS36130	COG2010	Cytochrome c
M4V62_RS36130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4V62_RS36135	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS36165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M4V62_RS36170	COG2124	cytochrome p450
M4V62_RS36170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M4V62_RS36195	COG0513	Belongs to the DEAD box helicase family
M4V62_RS36200	COG1278	Cold shock
M4V62_RS36215	COG1191	sigma factor activity
M4V62_RS36235	COG4585	Histidine kinase
M4V62_RS36240	COG2197	response regulator
M4V62_RS36275	COG1191	sigma factor activity
M4V62_RS36290	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M4V62_RS36295	COG2706	6-phosphogluconolactonase activity
M4V62_RS36310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M4V62_RS36320	COG2040	homocysteine
M4V62_RS36330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS36340	COG4166	transmembrane transport
M4V62_RS36345	COG1940	carbohydrate kinase activity
M4V62_RS36390	COG1902	pentaerythritol trinitrate reductase activity
M4V62_RS36395	COG0640	Transcriptional regulator
M4V62_RS36430	COG1309	transcriptional regulator
M4V62_RS36445	COG0671	phosphoesterase, PA-phosphatase related
M4V62_RS36465	COG1846	Transcriptional regulator
M4V62_RS36475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS36480	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS36485	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS36495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M4V62_RS36500	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M4V62_RS36520	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4V62_RS36545	COG0584	glycerophosphoryl diester phosphodiesterase
M4V62_RS36555	COG1597	lipid kinase activity
M4V62_RS36565	COG4221	oxidoreductase activity
M4V62_RS36585	COG0583	DNA-binding transcription factor activity
M4V62_RS36590	COG0477	Major facilitator Superfamily
M4V62_RS36595	COG0477	Major facilitator Superfamily
M4V62_RS36600	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS36605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M4V62_RS36610	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS36640	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS36675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4V62_RS36680	COG2301	Belongs to the HpcH HpaI aldolase family
M4V62_RS36700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS36705	COG0657	acetylesterase activity
M4V62_RS36735	COG0204	Acyl-transferase
M4V62_RS36745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M4V62_RS36755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M4V62_RS36770	COG0515	serine threonine protein kinase
M4V62_RS36785	COG3345	alpha-galactosidase
M4V62_RS36800	COG0395	ABC-type sugar transport system, permease component
M4V62_RS36845	COG0640	Transcriptional regulator
M4V62_RS36855	COG1660	Displays ATPase and GTPase activities
M4V62_RS36865	COG0445	tRNA wobble uridine modification
M4V62_RS36880	COG3903	Transcriptional regulator
M4V62_RS36880	COG3629	intracellular signal transduction
M4V62_RS36885	COG2409	Drug exporters of the RND superfamily
M4V62_RS36890	COG4585	Histidine kinase
M4V62_RS36895	COG2197	response regulator
M4V62_RS36920	COG1309	transcriptional regulator
M4V62_RS36945	COG2223	nitrite transmembrane transporter activity
M4V62_RS36950	COG1940	carbohydrate kinase activity
M4V62_RS37000	COG0577	efflux transmembrane transporter activity
M4V62_RS37000	COG1136	(ABC) transporter
M4V62_RS37025	COG1349	DNA-binding transcription factor activity
M4V62_RS37035	COG0464	growth
M4V62_RS37065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M4V62_RS37100	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS37105	COG2813	Specifically methylates the guanine in position
M4V62_RS37110	COG0300	oxidoreductase activity
M4V62_RS37115	COG0583	DNA-binding transcription factor activity
M4V62_RS37135	COG0277	FAD linked oxidase domain protein
M4V62_RS37145	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37150	COG1175	transmembrane transport
M4V62_RS37180	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS37190	COG0549	Belongs to the carbamate kinase family
M4V62_RS37195	COG2508	Transcriptional regulator
M4V62_RS37205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M4V62_RS37210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M4V62_RS37235	COG4733	cellulase activity
M4V62_RS37250	COG1175	transmembrane transport
M4V62_RS37255	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37260	COG1609	Transcriptional regulator
M4V62_RS37270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS37275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M4V62_RS37280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS37300	COG3507	Belongs to the glycosyl hydrolase 43 family
M4V62_RS37305	COG5297	Belongs to the glycosyl hydrolase family 6
M4V62_RS37330	COG3401	FG-GAP repeat protein
M4V62_RS37355	COG4677	pectinesterase activity
M4V62_RS37360	COG3866	Pectate lyase
M4V62_RS37365	COG2755	lipolytic protein G-D-S-L family
M4V62_RS37370	COG1653	transport
M4V62_RS37390	COG0673	inositol 2-dehydrogenase activity
M4V62_RS37395	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37400	COG1175	transmembrane transport
M4V62_RS37410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M4V62_RS37415	COG1802	Transcriptional regulator
M4V62_RS37425	COG1175	transmembrane transport
M4V62_RS37430	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37455	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37460	COG4209	transmembrane transport
M4V62_RS37475	COG1501	Belongs to the glycosyl hydrolase 31 family
M4V62_RS37480	COG5297	Belongs to the glycosyl hydrolase family 6
M4V62_RS37495	COG4214	carbohydrate transport
M4V62_RS37525	COG1414	Transcriptional regulator
M4V62_RS37530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M4V62_RS37545	COG1609	Transcriptional regulator
M4V62_RS37550	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37555	COG1175	transmembrane transport
M4V62_RS37565	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4V62_RS37565	COG1902	pentaerythritol trinitrate reductase activity
M4V62_RS37595	COG1461	Dihydroxyacetone kinase
M4V62_RS37600	COG2376	Dihydroxyacetone kinase
M4V62_RS37610	COG1609	Transcriptional regulator
M4V62_RS37625	COG0395	ABC-type sugar transport system, permease component
M4V62_RS37635	COG3693	PFAM glycoside hydrolase, family 10
M4V62_RS37650	COG0583	DNA-binding transcription factor activity
M4V62_RS37725	COG4209	transmembrane transport
M4V62_RS37730	COG1609	Transcriptional regulator
M4V62_RS37735	COG0702	epimerase
M4V62_RS37740	COG1595	DNA-templated transcription, initiation
M4V62_RS37755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M4V62_RS37810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M4V62_RS37890	COG2124	cytochrome p450
M4V62_RS37905	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS37910	COG0477	Major facilitator Superfamily
M4V62_RS37915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M4V62_RS37920	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M4V62_RS37920	COG1082	Xylose isomerase domain protein TIM barrel
M4V62_RS37935	COG2814	Major facilitator Superfamily
M4V62_RS37940	COG1070	Carbohydrate kinase
M4V62_RS37945	COG1070	Carbohydrate kinase
M4V62_RS37950	COG0588	phosphoglycerate mutase activity
M4V62_RS37965	COG0515	serine threonine protein kinase
M4V62_RS37975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M4V62_RS37980	COG2070	2-Nitropropane dioxygenase
M4V62_RS37995	COG1846	Transcriptional regulator
M4V62_RS38000	COG2366	antibiotic biosynthetic process
M4V62_RS38005	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS38015	COG2267	carboxylic ester hydrolase activity
M4V62_RS38020	COG1605	Chorismate mutase
M4V62_RS38030	COG1024	Enoyl-CoA hydratase
M4V62_RS38065	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M4V62_RS38065	COG1672	PFAM Archaeal ATPase
M4V62_RS38100	COG1846	Transcriptional regulator
M4V62_RS38100	COG1940	carbohydrate kinase activity
M4V62_RS38105	COG1129	ABC transporter
M4V62_RS38110	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS38150	COG2197	response regulator
M4V62_RS38155	COG4585	Histidine kinase
M4V62_RS38180	COG1349	DNA-binding transcription factor activity
M4V62_RS38190	COG0494	nUDIX hydrolase
M4V62_RS38200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M4V62_RS38240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M4V62_RS38265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M4V62_RS38290	COG1486	melibiose metabolic process
M4V62_RS38295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M4V62_RS38300	COG0395	ABC-type sugar transport system, permease component
M4V62_RS38320	COG1349	DNA-binding transcription factor activity
M4V62_RS38325	COG0181	hydroxymethylbilane synthase activity
M4V62_RS38345	COG2764	glyoxalase bleomycin resistance protein dioxygenase
M4V62_RS38350	COG4166	transmembrane transport
M4V62_RS38360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS38370	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS38380	COG3813	Protein conserved in bacteria
M4V62_RS38395	COG1793	dna ligase
M4V62_RS38415	COG1686	Belongs to the peptidase S11 family
M4V62_RS38425	COG2249	NAD(P)H dehydrogenase (quinone) activity
M4V62_RS38435	COG0386	Belongs to the glutathione peroxidase family
M4V62_RS38465	COG1228	amidohydrolase
M4V62_RS38485	COG0366	Alpha amylase catalytic
M4V62_RS38495	COG2706	6-phosphogluconolactonase activity
M4V62_RS38545	COG1175	transmembrane transport
M4V62_RS38565	COG0789	Transcriptional regulator
M4V62_RS38570	COG1819	glycosyl
M4V62_RS38580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M4V62_RS38605	COG1309	transcriptional regulator
M4V62_RS38645	COG1073	alpha beta
M4V62_RS38650	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS38655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M4V62_RS38665	COG0477	Major facilitator Superfamily
M4V62_RS38670	COG0318	PFAM AMP-dependent synthetase and ligase
M4V62_RS38675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS38675	COG3321	synthase
M4V62_RS38690	COG0604	alcohol dehydrogenase
M4V62_RS38710	COG1132	(ABC) transporter
M4V62_RS38715	COG2318	DinB family
M4V62_RS38735	COG4221	oxidoreductase activity
M4V62_RS38780	COG1175	transmembrane transport
M4V62_RS38785	COG0395	ABC-type sugar transport system, permease component
M4V62_RS38790	COG2723	6-phospho-beta-galactosidase activity
M4V62_RS38800	COG2274	protein secretion by the type I secretion system
M4V62_RS38810	COG1174	glycine betaine transport
M4V62_RS38815	COG1174	glycine betaine transport
M4V62_RS38830	COG1556	Lactate utilization protein
M4V62_RS38835	COG1139	Iron-sulfur cluster binding protein
M4V62_RS38840	COG0247	lactate metabolic process
M4V62_RS38845	COG1070	Carbohydrate kinase
M4V62_RS38850	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS38850	COG3347	Dehydrogenase
M4V62_RS38860	COG3250	beta-galactosidase activity
M4V62_RS38865	COG1129	ABC transporter
M4V62_RS38870	COG1172	Belongs to the binding-protein-dependent transport system permease family
M4V62_RS38885	COG1609	Transcriptional regulator
M4V62_RS38905	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS38920	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS38925	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS38935	COG0601	transmembrane transport
M4V62_RS38940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M4V62_RS38945	COG0444	Belongs to the ABC transporter superfamily
M4V62_RS38950	COG4608	Belongs to the ABC transporter superfamily
M4V62_RS39000	COG1733	regulation of RNA biosynthetic process
M4V62_RS39015	COG0745	RESPONSE REGULATOR receiver
M4V62_RS39020	COG2205	protein histidine kinase activity
M4V62_RS39025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M4V62_RS39035	COG1132	(ABC) transporter
M4V62_RS39055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS39065	COG0475	glutathione-regulated potassium exporter activity
M4V62_RS39075	COG2124	cytochrome p450
M4V62_RS39080	COG2124	cytochrome p450
M4V62_RS39120	COG0577	efflux transmembrane transporter activity
M4V62_RS39120	COG1136	(ABC) transporter
M4V62_RS39125	COG0577	efflux transmembrane transporter activity
M4V62_RS39125	COG1136	(ABC) transporter
M4V62_RS39145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M4V62_RS39155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M4V62_RS39160	COG0384	phenazine biosynthesis protein PhzF
M4V62_RS39190	COG0009	L-threonylcarbamoyladenylate synthase
M4V62_RS39255	COG3896	Chloramphenicol phosphotransferase-like protein
M4V62_RS39270	COG0789	Transcriptional regulator
M4V62_RS39275	COG0659	secondary active sulfate transmembrane transporter activity
M4V62_RS39280	COG2272	Belongs to the type-B carboxylesterase lipase family
M4V62_RS39340	COG2318	DinB family
M4V62_RS39355	COG3250	beta-galactosidase activity
M4V62_RS39415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4V62_RS39450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M4V62_RS39490	COG3321	synthase
M4V62_RS39490	COG0604	alcohol dehydrogenase
M4V62_RS39495	COG0604	alcohol dehydrogenase
M4V62_RS39495	COG3321	synthase
M4V62_RS39505	COG2197	response regulator
M4V62_RS39605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M4V62_RS39655	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M4V62_RS39695	COG1042	CoA-binding domain protein
M4V62_RS39695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M4V62_RS39695	COG0045	succinate-CoA ligase (ADP-forming) activity
M4V62_RS39700	COG0516	GMP reductase activity
M4V62_RS39700	COG0517	IMP dehydrogenase activity
M4V62_RS39720	COG0517	IMP dehydrogenase activity
M4V62_RS39720	COG0516	GMP reductase activity
M4V62_RS39735	COG2814	Major facilitator Superfamily
M4V62_RS39780	COG0477	Major facilitator Superfamily
M4V62_RS39825	COG0179	Fumarylacetoacetate (FAA) hydrolase
M4V62_RS39840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M4V62_RS39850	COG0179	Fumarylacetoacetate (FAA) hydrolase
M4V62_RS39870	COG2124	cytochrome p450
M4V62_RS39945	COG2022	thiamine diphosphate biosynthetic process
M4V62_RS39945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M4V62_RS39965	COG0277	FAD linked oxidase domain protein
M4V62_RS40000	COG3903	Transcriptional regulator
M4V62_RS40000	COG3629	intracellular signal transduction
M4V62_RS40020	COG1309	transcriptional regulator
M4V62_RS40025	COG1063	alcohol dehydrogenase
M4V62_RS40030	COG0667	Aldo Keto reductase
M4V62_RS40055	COG4221	oxidoreductase activity
M4V62_RS40080	COG1073	alpha beta
M4V62_RS40090	COG1228	amidohydrolase
M4V62_RS40105	COG1278	Cold shock
M4V62_RS40150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M4V62_RS40160	COG1024	Enoyl-CoA hydratase
M4V62_RS40185	COG0069	glutamate synthase activity
M4V62_RS40215	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS40240	COG0789	Transcriptional regulator
M4V62_RS40260	COG1846	Transcriptional regulator
M4V62_RS40260	COG1940	carbohydrate kinase activity
M4V62_RS40265	COG1070	Carbohydrate kinase
M4V62_RS40290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M4V62_RS40295	COG3239	Fatty acid desaturase
M4V62_RS40370	COG2018	Roadblock/LC7 domain
M4V62_RS40385	COG2409	Drug exporters of the RND superfamily
M4V62_RS40390	COG1946	Acyl-CoA thioesterase
M4V62_RS40415	COG1132	(ABC) transporter
M4V62_RS40420	COG1132	(ABC) transporter
M4V62_RS40435	COG1301	dicarboxylic acid transport
M4V62_RS40450	COG1846	Transcriptional regulator
M4V62_RS40455	COG1132	(ABC) transporter
M4V62_RS40465	COG2072	flavoprotein involved in K transport
M4V62_RS40480	COG1116	anion transmembrane transporter activity
M4V62_RS40485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M4V62_RS40490	COG0432	Pfam Uncharacterised protein family UPF0047
M4V62_RS40495	COG2197	response regulator
M4V62_RS40500	COG4585	Histidine kinase
M4V62_RS40505	COG2409	Drug exporters of the RND superfamily
M4V62_RS40535	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS40560	COG2770	Histidine kinase
M4V62_RS40560	COG2208	phosphoserine phosphatase activity
M4V62_RS40565	COG3629	intracellular signal transduction
M4V62_RS40565	COG3903	Transcriptional regulator
M4V62_RS40585	COG2814	Major facilitator Superfamily
M4V62_RS40610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M4V62_RS40615	COG0673	inositol 2-dehydrogenase activity
M4V62_RS40620	COG0673	inositol 2-dehydrogenase activity
M4V62_RS40640	COG1175	transmembrane transport
M4V62_RS40645	COG0395	ABC-type sugar transport system, permease component
M4V62_RS40670	COG1802	Transcriptional regulator
M4V62_RS40690	COG2508	Transcriptional regulator
M4V62_RS40710	COG2226	methyltransferase
M4V62_RS40715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M4V62_RS40720	COG1120	ATPase activity
M4V62_RS40730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M4V62_RS40785	COG3629	intracellular signal transduction
M4V62_RS40785	COG3903	Transcriptional regulator
M4V62_RS40795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M4V62_RS40800	COG1960	acyl-CoA dehydrogenase activity
M4V62_RS40805	COG0431	NADPH-dependent FMN reductase
M4V62_RS40920	COG0477	Major facilitator Superfamily
M4V62_RS40950	COG2226	methyltransferase
M4V62_RS40990	COG2124	cytochrome p450
M4V62_RS40995	COG0583	DNA-binding transcription factor activity
M4V62_RS41015	COG1335	isochorismatase
M4V62_RS41035	COG1653	transport
M4V62_RS41050	COG0640	Transcriptional regulator
M4V62_RS41055	COG1012	belongs to the aldehyde dehydrogenase family
M4V62_RS41070	COG0583	DNA-binding transcription factor activity
M4V62_RS41075	COG1414	Transcriptional regulator
M4V62_RS41080	COG1902	pentaerythritol trinitrate reductase activity
M4V62_RS41080	COG0446	pyridine nucleotide-disulphide oxidoreductase
M4V62_RS41085	COG4638	Rieske (2fe-2S)
M4V62_RS41095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M4V62_RS41120	COG1595	DNA-templated transcription, initiation
M4V62_RS41135	COG0346	lactoylglutathione lyase activity
M4V62_RS41140	COG0640	Transcriptional regulator
M4V62_RS41145	COG1064	alcohol dehydrogenase
M4V62_RS41150	COG1309	transcriptional regulator
M4V62_RS41165	COG1846	Transcriptional regulator
M4V62_RS41165	COG1940	carbohydrate kinase activity
M4V62_RS41175	COG1175	transmembrane transport
M4V62_RS41180	COG0395	ABC-type sugar transport system, permease component
M4V62_RS41275	COG0640	Transcriptional regulator
M4V62_RS41280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M4V62_RS41285	COG0573	inorganic phosphate transmembrane transporter activity
M4V62_RS41295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M4V62_RS41300	COG0745	RESPONSE REGULATOR receiver
M4V62_RS41310	COG1063	alcohol dehydrogenase
M4V62_RS41340	COG2080	2 iron, 2 sulfur cluster binding
M4V62_RS41345	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M4V62_RS41350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M4V62_RS41355	COG3608	succinylglutamate desuccinylase aspartoacylase
M4V62_RS41355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M4V62_RS41360	COG0277	FAD linked oxidase domain protein
M4V62_RS41360	COG0247	lactate metabolic process
M4V62_RS41365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M4V62_RS41430	COG4716	Myosin-crossreactive antigen
M4V62_RS41440	COG1309	transcriptional regulator
M4V62_RS41470	COG1595	DNA-templated transcription, initiation
M4V62_RS41490	COG2072	flavoprotein involved in K transport
M4V62_RS41495	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS41515	COG1653	transport
M4V62_RS41525	COG0395	ABC-type sugar transport system, permease component
M4V62_RS41560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M4V62_RS41580	COG3226	Transcriptional regulator
M4V62_RS41590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M4V62_RS41635	COG2188	Transcriptional regulator
M4V62_RS41645	COG1175	transmembrane transport
M4V62_RS41650	COG0395	ABC-type sugar transport system, permease component
M4V62_RS41655	COG4948	Mandelate Racemase Muconate Lactonizing
M4V62_RS41705	COG2188	Transcriptional regulator
M4V62_RS41730	COG0494	nUDIX hydrolase
M4V62_RS41735	COG2045	Belongs to the ComB family
M4V62_RS41760	COG0202	RNA polymerase activity
M4V62_RS41775	COG0745	RESPONSE REGULATOR receiver
M4V62_RS41780	COG2205	protein histidine kinase activity
M4V62_RS41825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M4V62_RS41870	COG2066	Belongs to the glutaminase family
M4V62_RS41900	COG3433	isochorismatase activity
M4V62_RS41900	COG2226	methyltransferase
M4V62_RS41900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS41905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M4V62_RS41915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M4V62_RS41955	COG2814	Major facilitator Superfamily
M4V62_RS41960	COG1846	Transcriptional regulator
M4V62_RS41980	COG0366	Alpha amylase catalytic
M4V62_RS41990	COG3281	Trehalose synthase
M4V62_RS41995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M4V62_RS42030	COG1846	Transcriptional regulator
M4V62_RS42070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M4V62_RS42075	COG3340	Belongs to the peptidase S51 family
M4V62_RS42090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M4V62_RS42095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M4V62_RS42100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M4V62_RS42120	COG3391	amine dehydrogenase activity
M4V62_RS42165	COG0151	Belongs to the GarS family
M4V62_RS42235	COG3655	Transcriptional regulator
M4V62_RS42285	COG0024	Methionine aminopeptidase
M4V62_RS42295	COG2252	PERMEase
M4V62_RS42300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M4V62_RS42305	COG2814	Major facilitator Superfamily
M4V62_RS42315	COG0583	DNA-binding transcription factor activity
M4V62_RS42320	COG2828	Protein conserved in bacteria
M4V62_RS42335	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS42380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M4V62_RS42395	COG1733	regulation of RNA biosynthetic process
M4V62_RS42465	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS42485	COG1309	transcriptional regulator
M4V62_RS42545	COG3629	intracellular signal transduction
M4V62_RS42545	COG3903	Transcriptional regulator
M4V62_RS42570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M4V62_RS42580	COG2233	PERMEase
M4V62_RS42590	COG0402	S-adenosylhomocysteine deaminase activity
M4V62_RS42595	COG2233	PERMEase
M4V62_RS42615	COG0477	Major facilitator Superfamily
M4V62_RS42625	COG0583	DNA-binding transcription factor activity
M4V62_RS42760	COG1846	Transcriptional regulator
M4V62_RS42835	COG1473	amidohydrolase
M4V62_RS42840	COG0477	Major facilitator Superfamily
M4V62_RS42855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M4V62_RS42895	COG3033	Beta-eliminating lyase
M4V62_RS42935	COG2964	Protein conserved in bacteria
M4V62_RS43025	COG3540	Alkaline phosphatase
M4V62_RS43105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M4V62_RS43225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M4V62_RS43225	COG3321	synthase
M4V62_RS43225	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS43225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M4V62_RS43225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M4V62_RS43250	COG0477	Major facilitator Superfamily
M4V62_RS43260	COG3321	synthase
M4V62_RS43260	COG0604	alcohol dehydrogenase
M4V62_RS43265	COG0604	alcohol dehydrogenase
M4V62_RS43265	COG3321	synthase
M4V62_RS43280	COG0604	alcohol dehydrogenase
M4V62_RS43280	COG3321	synthase
M4V62_RS43290	COG3321	synthase
M4V62_RS43290	COG0604	alcohol dehydrogenase
M4V62_RS43290	COG1028	Short-chain dehydrogenase reductase Sdr
M4V62_RS43295	COG0644	oxidoreductase
M4V62_RS43335	COG1250	3-hydroxyacyl-CoA dehydrogenase
M4V62_RS43345	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M4V62_RS43350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M4V62_RS43385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M4V62_RS43455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M4V62_RS43460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids