locus-tag	class	description
GFH48_RS00020	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS00045	COG3845	ABC transporter
GFH48_RS00110	COG1278	Cold shock
GFH48_RS00125	COG0431	NADPH-dependent FMN reductase
GFH48_RS00135	COG0477	Major facilitator Superfamily
GFH48_RS00155	COG0142	geranyltranstransferase activity
GFH48_RS00275	COG3903	Transcriptional regulator
GFH48_RS00275	COG3629	intracellular signal transduction
GFH48_RS00355	COG2124	cytochrome p450
GFH48_RS00360	COG1024	Enoyl-CoA hydratase
GFH48_RS00365	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH48_RS00380	COG2409	Drug exporters of the RND superfamily
GFH48_RS00390	COG2197	response regulator
GFH48_RS00400	COG0129	dihydroxy-acid dehydratase activity
GFH48_RS00435	COG0657	acetylesterase activity
GFH48_RS00450	COG3842	ATPase activity
GFH48_RS00470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH48_RS00475	COG0473	3-isopropylmalate dehydrogenase activity
GFH48_RS00530	COG0477	Major facilitator Superfamily
GFH48_RS00575	COG0596	Alpha beta hydrolase
GFH48_RS00585	COG0784	Response regulator, receiver
GFH48_RS00590	COG4251	negative regulation of phosphorylation
GFH48_RS00600	COG1295	ribonuclease BN
GFH48_RS00620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH48_RS00645	COG1595	DNA-templated transcription, initiation
GFH48_RS00675	COG3655	Transcriptional regulator
GFH48_RS00740	COG3961	Belongs to the TPP enzyme family
GFH48_RS00755	COG0477	Major facilitator Superfamily
GFH48_RS00760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH48_RS00775	COG1733	regulation of RNA biosynthetic process
GFH48_RS00785	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS00790	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS00795	COG1129	ABC transporter
GFH48_RS00800	COG1879	ABC-type sugar transport system periplasmic component
GFH48_RS00805	COG1609	Transcriptional regulator
GFH48_RS00810	COG3250	beta-galactosidase activity
GFH48_RS00835	COG1428	Deoxynucleoside kinase
GFH48_RS00890	COG0300	oxidoreductase activity
GFH48_RS00905	COG1733	regulation of RNA biosynthetic process
GFH48_RS00975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS00990	COG1733	regulation of RNA biosynthetic process
GFH48_RS01035	COG4585	Histidine kinase
GFH48_RS01040	COG2197	response regulator
GFH48_RS01050	COG2272	Belongs to the type-B carboxylesterase lipase family
GFH48_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS01130	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GFH48_RS01225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH48_RS01265	COG1404	Belongs to the peptidase S8 family
GFH48_RS01295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS01300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS01305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS01310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS01340	COG4166	transmembrane transport
GFH48_RS01350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS01355	COG4172	Belongs to the ABC transporter superfamily
GFH48_RS01360	COG1609	Transcriptional regulator
GFH48_RS01375	COG0154	amidase activity
GFH48_RS01385	COG1073	alpha beta
GFH48_RS01390	COG0667	Aldo Keto reductase
GFH48_RS01400	COG4977	sequence-specific DNA binding
GFH48_RS01405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH48_RS01425	COG2318	DinB family
GFH48_RS01440	COG1309	transcriptional regulator
GFH48_RS01445	COG0539	negative regulation of cytoplasmic translation
GFH48_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS01475	COG2814	Major facilitator Superfamily
GFH48_RS01485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH48_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS01555	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH48_RS01565	COG2186	Transcriptional regulator
GFH48_RS01575	COG1175	transmembrane transport
GFH48_RS01580	COG0395	ABC-type sugar transport system, permease component
GFH48_RS01615	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH48_RS01635	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS01640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS01665	COG1940	carbohydrate kinase activity
GFH48_RS01670	COG4214	carbohydrate transport
GFH48_RS01680	COG4213	ABC transporter substrate-binding protein
GFH48_RS01700	COG2197	response regulator
GFH48_RS01705	COG4585	Histidine kinase
GFH48_RS01720	COG1609	Transcriptional regulator
GFH48_RS01730	COG1175	transmembrane transport
GFH48_RS01740	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH48_RS01755	COG1404	Belongs to the peptidase S8 family
GFH48_RS01765	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GFH48_RS01770	COG1309	transcriptional regulator
GFH48_RS01790	COG0667	Aldo Keto reductase
GFH48_RS01795	COG1063	alcohol dehydrogenase
GFH48_RS01805	COG1621	beta-fructofuranosidase activity
GFH48_RS01805	COG3583	domain protein
GFH48_RS01805	COG5492	domain, Protein
GFH48_RS01830	COG0667	Aldo Keto reductase
GFH48_RS01835	COG4989	oxidoreductase activity
GFH48_RS01855	COG0483	inositol monophosphate 1-phosphatase activity
GFH48_RS01860	COG0583	DNA-binding transcription factor activity
GFH48_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS01955	COG0492	ferredoxin-NADP+ reductase activity
GFH48_RS01960	COG5297	Belongs to the glycosyl hydrolase family 6
GFH48_RS01965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GFH48_RS02005	COG3537	Alpha-1,2-mannosidase
GFH48_RS02015	COG0789	Transcriptional regulator
GFH48_RS02040	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH48_RS02040	COG1672	PFAM Archaeal ATPase
GFH48_RS02070	COG0702	epimerase
GFH48_RS02080	COG3250	beta-galactosidase activity
GFH48_RS02085	COG3142	Participates in the control of copper homeostasis
GFH48_RS02095	COG1940	carbohydrate kinase activity
GFH48_RS02095	COG1846	Transcriptional regulator
GFH48_RS02120	COG1940	carbohydrate kinase activity
GFH48_RS02140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS02160	COG2770	Histidine kinase
GFH48_RS02160	COG2208	phosphoserine phosphatase activity
GFH48_RS02175	COG1278	Cold shock
GFH48_RS02195	COG1131	(ABC) transporter
GFH48_RS02205	COG1595	DNA-templated transcription, initiation
GFH48_RS02250	COG1397	ADP-ribosylglycohydrolase
GFH48_RS02255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFH48_RS02260	COG2050	protein possibly involved in aromatic compounds catabolism
GFH48_RS02295	COG0028	Belongs to the TPP enzyme family
GFH48_RS02300	COG2197	response regulator
GFH48_RS02310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH48_RS02330	COG1940	carbohydrate kinase activity
GFH48_RS02335	COG0395	ABC-type sugar transport system, permease component
GFH48_RS02345	COG1653	transport
GFH48_RS02350	COG1063	alcohol dehydrogenase
GFH48_RS02355	COG1082	Xylose isomerase domain protein TIM barrel
GFH48_RS02360	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GFH48_RS02405	COG0395	ABC-type sugar transport system, permease component
GFH48_RS02410	COG1175	transmembrane transport
GFH48_RS02420	COG1609	Transcriptional regulator
GFH48_RS02425	COG3250	beta-galactosidase activity
GFH48_RS02445	COG0514	ATP-dependent DNA helicase (RecQ)
GFH48_RS02450	COG3158	transport of potassium into the cell
GFH48_RS02490	COG0667	Aldo Keto reductase
GFH48_RS02495	COG0583	DNA-binding transcription factor activity
GFH48_RS02510	COG2909	trisaccharide binding
GFH48_RS02515	COG0426	domain, Protein
GFH48_RS02515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH48_RS02520	COG3485	protocatechuate 3,4-dioxygenase
GFH48_RS02555	COG3409	Peptidoglycan-binding domain 1 protein
GFH48_RS02555	COG3773	Cell wall hydrolase
GFH48_RS02570	COG0494	nUDIX hydrolase
GFH48_RS02585	COG2197	response regulator
GFH48_RS02590	COG4585	Histidine kinase
GFH48_RS02635	COG0577	efflux transmembrane transporter activity
GFH48_RS02635	COG1136	(ABC) transporter
GFH48_RS02640	COG4591	ABC-type transport system involved in lipoprotein release permease component
GFH48_RS02640	COG1136	(ABC) transporter
GFH48_RS02650	COG4221	oxidoreductase activity
GFH48_RS02655	COG1733	regulation of RNA biosynthetic process
GFH48_RS02685	COG1136	(ABC) transporter
GFH48_RS02685	COG0577	efflux transmembrane transporter activity
GFH48_RS02690	COG4585	Histidine kinase
GFH48_RS02695	COG2197	response regulator
GFH48_RS02710	COG1309	transcriptional regulator
GFH48_RS02715	COG2226	methyltransferase
GFH48_RS02725	COG0745	RESPONSE REGULATOR receiver
GFH48_RS02730	COG2205	protein histidine kinase activity
GFH48_RS02755	COG4106	trans-aconitate 2-methyltransferase activity
GFH48_RS02765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFH48_RS02775	COG0436	Aminotransferase
GFH48_RS02790	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS02795	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS02825	COG0076	glutamate decarboxylase activity
GFH48_RS02850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH48_RS02855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFH48_RS02860	COG0066	3-isopropylmalate dehydratase activity
GFH48_RS02865	COG0473	3-isopropylmalate dehydrogenase activity
GFH48_RS02890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFH48_RS02920	COG3547	Transposase (IS116 IS110 IS902 family)
GFH48_RS03005	COG3537	Alpha-1,2-mannosidase
GFH48_RS03015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS03035	COG3979	chitinase
GFH48_RS03040	COG3848	Pyruvate phosphate dikinase
GFH48_RS03040	COG0574	Belongs to the PEP-utilizing enzyme family
GFH48_RS03050	COG0640	Transcriptional regulator
GFH48_RS03095	COG0402	S-adenosylhomocysteine deaminase activity
GFH48_RS03105	COG3485	protocatechuate 3,4-dioxygenase
GFH48_RS03110	COG1414	Transcriptional regulator
GFH48_RS03140	COG0672	)-iron permease
GFH48_RS03155	COG4585	Histidine kinase
GFH48_RS03160	COG2197	response regulator
GFH48_RS03180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS03210	COG1024	Enoyl-CoA hydratase
GFH48_RS03235	COG1846	Transcriptional regulator
GFH48_RS03265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH48_RS03285	COG2837	iron assimilation
GFH48_RS03290	COG1289	transmembrane transporter activity
GFH48_RS03295	COG0431	NADPH-dependent FMN reductase
GFH48_RS03300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS03370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH48_RS03390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH48_RS03410	COG1271	oxidase subunit
GFH48_RS03425	COG0243	molybdopterin cofactor binding
GFH48_RS03445	COG2197	response regulator
GFH48_RS03450	COG4585	Histidine kinase
GFH48_RS03455	COG2132	Multicopper oxidase
GFH48_RS03460	COG2409	Drug exporters of the RND superfamily
GFH48_RS03500	COG0601	transmembrane transport
GFH48_RS03505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS03510	COG0444	Belongs to the ABC transporter superfamily
GFH48_RS03515	COG4608	Belongs to the ABC transporter superfamily
GFH48_RS03520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS03525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS03545	COG0248	Ppx GppA phosphatase
GFH48_RS03565	COG1073	alpha beta
GFH48_RS03580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH48_RS03585	COG1414	Transcriptional regulator
GFH48_RS03610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GFH48_RS03635	COG0509	glycine decarboxylation via glycine cleavage system
GFH48_RS03645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GFH48_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS03695	COG0739	heme binding
GFH48_RS03765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH48_RS03765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH48_RS03785	COG2318	DinB family
GFH48_RS03790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH48_RS03815	COG2326	polyphosphate kinase activity
GFH48_RS03910	COG2770	Histidine kinase
GFH48_RS03910	COG2208	phosphoserine phosphatase activity
GFH48_RS03930	COG0783	Belongs to the Dps family
GFH48_RS03940	COG1191	sigma factor activity
GFH48_RS03945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFH48_RS03975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH48_RS04000	COG0009	L-threonylcarbamoyladenylate synthase
GFH48_RS04010	COG0443	Heat shock 70 kDa protein
GFH48_RS04015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFH48_RS04030	COG0542	response to heat
GFH48_RS04040	COG1414	Transcriptional regulator
GFH48_RS04045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS04050	COG4948	Mandelate Racemase Muconate Lactonizing
GFH48_RS04065	COG1136	(ABC) transporter
GFH48_RS04070	COG3851	Histidine kinase
GFH48_RS04075	COG2197	response regulator
GFH48_RS04090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GFH48_RS04095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH48_RS04115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFH48_RS04120	COG0254	rRNA binding
GFH48_RS04125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFH48_RS04135	COG0583	DNA-binding transcription factor activity
GFH48_RS04140	COG5006	permease, DMT superfamily
GFH48_RS04155	COG0477	Major facilitator Superfamily
GFH48_RS04205	COG0464	growth
GFH48_RS04285	COG2268	Band 7 protein
GFH48_RS04325	COG3237	CsbD-like
GFH48_RS04345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS04355	COG0747	negative chemotaxis
GFH48_RS04375	COG2226	methyltransferase
GFH48_RS04430	COG5002	protein histidine kinase activity
GFH48_RS04480	COG1716	ATPase activity
GFH48_RS04480	COG0842	Transport permease protein
GFH48_RS04480	COG1131	(ABC) transporter
GFH48_RS04555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH48_RS04560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS04565	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS04600	COG1024	Enoyl-CoA hydratase
GFH48_RS04610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH48_RS04625	COG0183	Belongs to the thiolase family
GFH48_RS04630	COG0583	DNA-binding transcription factor activity
GFH48_RS04635	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS04645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFH48_RS04675	COG3250	beta-galactosidase activity
GFH48_RS04685	COG0515	serine threonine protein kinase
GFH48_RS04715	COG3647	Membrane
GFH48_RS04720	COG0667	Aldo Keto reductase
GFH48_RS04750	COG2340	Cysteine-rich secretory protein family
GFH48_RS04780	COG0596	Alpha beta hydrolase
GFH48_RS04805	COG0667	Aldo Keto reductase
GFH48_RS04840	COG1309	transcriptional regulator
GFH48_RS04905	COG4191	Histidine kinase
GFH48_RS04910	COG1295	ribonuclease BN
GFH48_RS04910	COG1959	2 iron, 2 sulfur cluster binding
GFH48_RS04950	COG2188	Transcriptional regulator
GFH48_RS04955	COG2175	clavaminate synthase activity
GFH48_RS04960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFH48_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS04980	COG4221	oxidoreductase activity
GFH48_RS04995	COG1132	(ABC) transporter
GFH48_RS05025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFH48_RS05035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH48_RS05055	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFH48_RS05155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH48_RS05185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFH48_RS05190	COG3250	beta-galactosidase activity
GFH48_RS05215	COG0596	Alpha beta hydrolase
GFH48_RS05270	COG2124	cytochrome p450
GFH48_RS05315	COG0531	amino acid
GFH48_RS05320	COG1228	amidohydrolase
GFH48_RS05325	COG2124	cytochrome p450
GFH48_RS05390	COG1595	DNA-templated transcription, initiation
GFH48_RS05405	COG1063	alcohol dehydrogenase
GFH48_RS05410	COG2814	Major facilitator Superfamily
GFH48_RS05435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFH48_RS05465	COG1796	DNA polymerase
GFH48_RS05465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFH48_RS05475	COG1940	carbohydrate kinase activity
GFH48_RS05480	COG2182	Extracellular solute-binding protein
GFH48_RS05485	COG1175	transmembrane transport
GFH48_RS05490	COG0395	ABC-type sugar transport system, permease component
GFH48_RS05495	COG2723	6-phospho-beta-galactosidase activity
GFH48_RS05520	COG0745	RESPONSE REGULATOR receiver
GFH48_RS05525	COG2205	protein histidine kinase activity
GFH48_RS05575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS05580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH48_RS05585	COG1611	Belongs to the LOG family
GFH48_RS05640	COG2706	6-phosphogluconolactonase activity
GFH48_RS05650	COG1309	transcriptional regulator
GFH48_RS05660	COG1357	PFAM Pentapeptide repeats (8 copies)
GFH48_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS05670	COG1024	Enoyl-CoA hydratase
GFH48_RS05680	COG1609	Transcriptional regulator
GFH48_RS05700	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS05705	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS05710	COG1129	ABC transporter
GFH48_RS05720	COG3347	Dehydrogenase
GFH48_RS05720	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS05725	COG1070	Carbohydrate kinase
GFH48_RS05730	COG0247	lactate metabolic process
GFH48_RS05735	COG1139	Iron-sulfur cluster binding protein
GFH48_RS05740	COG1556	Lactate utilization protein
GFH48_RS05755	COG1174	glycine betaine transport
GFH48_RS05760	COG1174	glycine betaine transport
GFH48_RS05775	COG0309	Hydrogenase expression formation protein (HypE)
GFH48_RS05785	COG0298	carbon dioxide binding
GFH48_RS05800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GFH48_RS05805	COG0375	protein maturation
GFH48_RS05835	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GFH48_RS05850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFH48_RS05850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH48_RS05995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH48_RS06015	COG2208	phosphoserine phosphatase activity
GFH48_RS06015	COG2770	Histidine kinase
GFH48_RS06045	COG3469	chitinase activity
GFH48_RS06060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS06075	COG4585	Histidine kinase
GFH48_RS06080	COG2197	response regulator
GFH48_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS06120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH48_RS06130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFH48_RS06145	COG3629	intracellular signal transduction
GFH48_RS06145	COG3903	Transcriptional regulator
GFH48_RS06190	COG3547	Transposase (IS116 IS110 IS902 family)
GFH48_RS06250	COG1595	DNA-templated transcription, initiation
GFH48_RS06425	COG1595	DNA-templated transcription, initiation
GFH48_RS06475	COG1366	Belongs to the anti-sigma-factor antagonist family
GFH48_RS06475	COG2208	phosphoserine phosphatase activity
GFH48_RS06475	COG2172	sigma factor antagonist activity
GFH48_RS06485	COG1309	transcriptional regulator
GFH48_RS06510	COG1595	DNA-templated transcription, initiation
GFH48_RS06600	COG3537	Alpha-1,2-mannosidase
GFH48_RS06645	COG0395	ABC-type sugar transport system, permease component
GFH48_RS06660	COG1609	Transcriptional regulator
GFH48_RS06715	COG3386	PFAM SMP-30 Gluconolaconase
GFH48_RS06720	COG0800	Aldolase
GFH48_RS06730	COG4948	Mandelate Racemase Muconate Lactonizing
GFH48_RS06735	COG2186	Transcriptional regulator
GFH48_RS06750	COG0395	ABC-type sugar transport system, permease component
GFH48_RS06755	COG1175	transmembrane transport
GFH48_RS06765	COG3345	alpha-galactosidase
GFH48_RS06810	COG3973	AAA domain
GFH48_RS06885	COG1228	amidohydrolase
GFH48_RS06900	COG2188	Transcriptional regulator
GFH48_RS06915	COG1132	(ABC) transporter
GFH48_RS06920	COG0583	DNA-binding transcription factor activity
GFH48_RS06950	COG0671	phosphoesterase, PA-phosphatase related
GFH48_RS06955	COG1404	Belongs to the peptidase S8 family
GFH48_RS06990	COG1191	sigma factor activity
GFH48_RS07000	COG0114	fumarate hydratase activity
GFH48_RS07010	COG0477	Major facilitator Superfamily
GFH48_RS07015	COG1335	isochorismatase
GFH48_RS07035	COG2326	polyphosphate kinase activity
GFH48_RS07120	COG0501	Belongs to the peptidase M48B family
GFH48_RS07135	COG0242	peptide deformylase activity
GFH48_RS07140	COG0488	(ABC) transporter
GFH48_RS07150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH48_RS07165	COG1609	Transcriptional regulator
GFH48_RS07180	COG2268	Band 7 protein
GFH48_RS07200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFH48_RS07205	COG0121	glutamine amidotransferase
GFH48_RS07210	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GFH48_RS07220	COG2182	Extracellular solute-binding protein
GFH48_RS07225	COG3360	Dodecin
GFH48_RS07235	COG1595	DNA-templated transcription, initiation
GFH48_RS07260	COG0667	Aldo Keto reductase
GFH48_RS07270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS07290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFH48_RS07295	COG1053	succinate dehydrogenase
GFH48_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS07320	COG2197	response regulator
GFH48_RS07360	COG0726	polysaccharide deacetylase
GFH48_RS07390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFH48_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS07430	COG4948	Mandelate Racemase Muconate Lactonizing
GFH48_RS07435	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS07440	COG1129	ABC transporter
GFH48_RS07445	COG1879	ABC-type sugar transport system periplasmic component
GFH48_RS07450	COG2186	Transcriptional regulator
GFH48_RS07470	COG0395	ABC-type sugar transport system, permease component
GFH48_RS07475	COG1175	transmembrane transport
GFH48_RS07510	COG0701	Predicted permease
GFH48_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS07535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFH48_RS07540	COG0297	glycogen (starch) synthase activity
GFH48_RS07560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFH48_RS07575	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFH48_RS07580	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GFH48_RS07600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFH48_RS07600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH48_RS07605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFH48_RS07610	COG1132	(ABC) transporter
GFH48_RS07620	COG1024	Enoyl-CoA hydratase
GFH48_RS07625	COG0668	transmembrane transport
GFH48_RS07630	COG2838	Isocitrate dehydrogenase
GFH48_RS07655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH48_RS07680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS07685	COG0698	ribose 5-phosphate isomerase
GFH48_RS07705	COG1522	sequence-specific DNA binding
GFH48_RS07710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH48_RS07715	COG0351	phosphomethylpyrimidine kinase
GFH48_RS07780	COG4821	SIS domain
GFH48_RS07785	COG1737	Transcriptional regulator
GFH48_RS07805	COG3033	Beta-eliminating lyase
GFH48_RS07840	COG3959	Transketolase, thiamine diphosphate binding domain
GFH48_RS07845	COG3958	Transketolase
GFH48_RS07870	COG0583	DNA-binding transcription factor activity
GFH48_RS07875	COG0156	8-amino-7-oxononanoate synthase activity
GFH48_RS07880	COG1063	alcohol dehydrogenase
GFH48_RS07885	COG0673	inositol 2-dehydrogenase activity
GFH48_RS07935	COG2755	lipolytic protein G-D-S-L family
GFH48_RS07945	COG2365	Tyrosine phosphatase family
GFH48_RS07965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFH48_RS07970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFH48_RS07985	COG1657	PFAM Prenyltransferase squalene oxidase
GFH48_RS07995	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GFH48_RS08005	COG1562	ergosterol biosynthetic process
GFH48_RS08010	COG1134	teichoic acid transport
GFH48_RS08055	COG2226	methyltransferase
GFH48_RS08060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GFH48_RS08070	COG1024	Enoyl-CoA hydratase
GFH48_RS08080	COG4977	sequence-specific DNA binding
GFH48_RS08090	COG2183	response to ionizing radiation
GFH48_RS08095	COG0488	(ABC) transporter
GFH48_RS08105	COG2936	dipeptidyl-peptidase activity
GFH48_RS08125	COG1113	amino acid transport
GFH48_RS08135	COG0789	Transcriptional regulator
GFH48_RS08140	COG1024	Enoyl-CoA hydratase
GFH48_RS08140	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS08145	COG0183	Belongs to the thiolase family
GFH48_RS08150	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS08160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH48_RS08165	COG3268	Saccharopine dehydrogenase
GFH48_RS08170	COG1515	deoxyribonuclease V activity
GFH48_RS08190	COG0488	(ABC) transporter
GFH48_RS08195	COG1834	amidinotransferase
GFH48_RS08265	COG1793	dna ligase
GFH48_RS08275	COG1846	Transcriptional regulator
GFH48_RS08290	COG3485	protocatechuate 3,4-dioxygenase
GFH48_RS08295	COG3485	protocatechuate 3,4-dioxygenase
GFH48_RS08305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS08310	COG1672	PFAM Archaeal ATPase
GFH48_RS08310	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH48_RS08340	COG3511	phospholipase C
GFH48_RS08365	COG1278	Cold shock
GFH48_RS08370	COG0513	Belongs to the DEAD box helicase family
GFH48_RS08395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS08420	COG1024	Enoyl-CoA hydratase
GFH48_RS08450	COG1309	transcriptional regulator
GFH48_RS08455	COG0477	Major facilitator Superfamily
GFH48_RS08460	COG0667	Aldo Keto reductase
GFH48_RS08485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH48_RS08490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH48_RS08505	COG0366	Alpha amylase catalytic
GFH48_RS08510	COG0395	ABC-type sugar transport system, permease component
GFH48_RS08515	COG1175	transmembrane transport
GFH48_RS08535	COG3938	Belongs to the proline racemase family
GFH48_RS08540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS08545	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH48_RS08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH48_RS08560	COG0006	proline dipeptidase activity
GFH48_RS08610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFH48_RS08620	COG3469	chitinase activity
GFH48_RS08630	COG1486	melibiose metabolic process
GFH48_RS08635	COG1349	DNA-binding transcription factor activity
GFH48_RS08640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH48_RS08650	COG1175	transmembrane transport
GFH48_RS08655	COG0395	ABC-type sugar transport system, permease component
GFH48_RS08660	COG3250	beta-galactosidase activity
GFH48_RS08695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFH48_RS08710	COG0166	Belongs to the GPI family
GFH48_RS08715	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GFH48_RS08720	COG0406	alpha-ribazole phosphatase activity
GFH48_RS08755	COG3467	pyridoxamine 5'-phosphate
GFH48_RS08795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH48_RS08815	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS08835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH48_RS08945	COG0714	Associated with various cellular activities
GFH48_RS08950	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GFH48_RS08965	COG3387	PFAM Glycoside hydrolase 15-related
GFH48_RS09005	COG3265	gluconokinase activity
GFH48_RS09010	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS09030	COG4637	Psort location Cytoplasmic, score
GFH48_RS09035	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH48_RS09035	COG0567	Dehydrogenase, E1 component
GFH48_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS09075	COG0045	succinate-CoA ligase (ADP-forming) activity
GFH48_RS09085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH48_RS09095	COG2223	nitrite transmembrane transporter activity
GFH48_RS09120	COG0673	inositol 2-dehydrogenase activity
GFH48_RS09125	COG1879	ABC-type sugar transport system periplasmic component
GFH48_RS09130	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS09135	COG1129	ABC transporter
GFH48_RS09140	COG1940	carbohydrate kinase activity
GFH48_RS09150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH48_RS09160	COG0667	Aldo Keto reductase
GFH48_RS09180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFH48_RS09185	COG3383	formate dehydrogenase (NAD+) activity
GFH48_RS09200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GFH48_RS09205	COG1335	isochorismatase
GFH48_RS09235	COG0656	L-ascorbic acid biosynthetic process
GFH48_RS09260	COG2378	regulation of single-species biofilm formation
GFH48_RS09275	COG2226	methyltransferase
GFH48_RS09280	COG2154	pterin-4-alpha-carbinolamine dehydratase
GFH48_RS09295	COG0443	Heat shock 70 kDa protein
GFH48_RS09360	COG0488	(ABC) transporter
GFH48_RS09380	COG0457	Tetratricopeptide repeat
GFH48_RS09395	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFH48_RS09405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH48_RS09410	COG2362	D-Aminopeptidase
GFH48_RS09445	COG2226	methyltransferase
GFH48_RS09450	COG2208	phosphoserine phosphatase activity
GFH48_RS09450	COG1366	Belongs to the anti-sigma-factor antagonist family
GFH48_RS09450	COG2172	sigma factor antagonist activity
GFH48_RS09470	COG0596	Alpha beta hydrolase
GFH48_RS09490	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS09500	COG0604	alcohol dehydrogenase
GFH48_RS09505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS09505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS09510	COG2301	Belongs to the HpcH HpaI aldolase family
GFH48_RS09520	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS09525	COG0688	phosphatidylethanolamine metabolic process
GFH48_RS09540	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS09545	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS09565	COG1929	Belongs to the glycerate kinase type-1 family
GFH48_RS09630	COG0671	phosphoesterase, PA-phosphatase related
GFH48_RS09640	COG2205	protein histidine kinase activity
GFH48_RS09670	COG5002	protein histidine kinase activity
GFH48_RS09675	COG0745	RESPONSE REGULATOR receiver
GFH48_RS09705	COG1309	transcriptional regulator
GFH48_RS09720	COG0583	DNA-binding transcription factor activity
GFH48_RS09725	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS09745	COG2814	Major facilitator Superfamily
GFH48_RS09750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GFH48_RS09770	COG0483	inositol monophosphate 1-phosphatase activity
GFH48_RS09790	COG2197	response regulator
GFH48_RS09805	COG2226	methyltransferase
GFH48_RS09815	COG1953	Uracil, thiamine, allantoin
GFH48_RS09825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH48_RS09865	COG0405	Gamma-glutamyltransferase
GFH48_RS09875	COG1073	alpha beta
GFH48_RS09880	COG0765	amino acid transport
GFH48_RS09885	COG0765	amino acid transport
GFH48_RS09895	COG1126	abc transporter atp-binding protein
GFH48_RS09915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFH48_RS09920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS09930	COG3485	protocatechuate 3,4-dioxygenase
GFH48_RS09935	COG1454	alcohol dehydrogenase
GFH48_RS09945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFH48_RS09955	COG0183	Belongs to the thiolase family
GFH48_RS09960	COG0583	DNA-binding transcription factor activity
GFH48_RS09970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH48_RS09980	COG1940	carbohydrate kinase activity
GFH48_RS10005	COG2188	Transcriptional regulator
GFH48_RS10010	COG0673	inositol 2-dehydrogenase activity
GFH48_RS10020	COG2197	response regulator
GFH48_RS10025	COG0667	Aldo Keto reductase
GFH48_RS10045	COG0598	Magnesium transport protein CorA
GFH48_RS10050	COG4266	Belongs to the allantoicase family
GFH48_RS10055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH48_RS10060	COG1414	Transcriptional regulator
GFH48_RS10070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH48_RS10080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFH48_RS10085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GFH48_RS10110	COG4264	IucA IucC family
GFH48_RS10115	COG2304	oxidoreductase activity
GFH48_RS10130	COG0436	Aminotransferase
GFH48_RS10145	COG0406	alpha-ribazole phosphatase activity
GFH48_RS10160	COG2233	PERMEase
GFH48_RS10175	COG2351	hydroxyisourate hydrolase activity
GFH48_RS10195	COG3622	Belongs to the hyi family
GFH48_RS10200	COG2084	Dehydrogenase
GFH48_RS10220	COG3960	tartronate-semialdehyde synthase activity
GFH48_RS10230	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS10235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH48_RS10240	COG2197	response regulator
GFH48_RS10260	COG0598	Magnesium transport protein CorA
GFH48_RS10265	COG2124	cytochrome p450
GFH48_RS10275	COG2159	amidohydrolase
GFH48_RS10290	COG0515	serine threonine protein kinase
GFH48_RS10295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH48_RS10305	COG0640	Transcriptional regulator
GFH48_RS10330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH48_RS10335	COG0596	Alpha beta hydrolase
GFH48_RS10340	COG1819	glycosyl
GFH48_RS10345	COG1132	(ABC) transporter
GFH48_RS10350	COG0726	polysaccharide deacetylase
GFH48_RS10355	COG5634	Uncharacterized conserved protein (DUF2278)
GFH48_RS10370	COG2252	PERMEase
GFH48_RS10375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFH48_RS10405	COG1802	Transcriptional regulator
GFH48_RS10425	COG0028	Belongs to the TPP enzyme family
GFH48_RS10460	COG1162	GTPase activity
GFH48_RS10480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH48_RS10505	COG0596	Alpha beta hydrolase
GFH48_RS10520	COG2040	homocysteine
GFH48_RS10560	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS10590	COG0175	sulfate reduction
GFH48_RS10595	COG0529	Catalyzes the synthesis of activated sulfate
GFH48_RS10620	COG1116	anion transmembrane transporter activity
GFH48_RS10625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH48_RS10635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFH48_RS10640	COG0667	Aldo Keto reductase
GFH48_RS10655	COG2409	Drug exporters of the RND superfamily
GFH48_RS10825	COG0642	Histidine kinase
GFH48_RS10865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH48_RS10870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFH48_RS10890	COG0330	HflC and HflK could
GFH48_RS10900	COG2326	polyphosphate kinase activity
GFH48_RS10905	COG4221	oxidoreductase activity
GFH48_RS10925	COG4152	abc transporter atp-binding protein
GFH48_RS10945	COG3220	belongs to the UPF0276 family
GFH48_RS10955	COG0596	Alpha beta hydrolase
GFH48_RS10960	COG3253	May function as heme-dependent peroxidase
GFH48_RS10965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GFH48_RS10975	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH48_RS10990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFH48_RS11005	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GFH48_RS11010	COG0183	Belongs to the thiolase family
GFH48_RS11015	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS11015	COG1024	Enoyl-CoA hydratase
GFH48_RS11035	COG0531	amino acid
GFH48_RS11040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFH48_RS11045	COG4214	carbohydrate transport
GFH48_RS11055	COG4213	ABC transporter substrate-binding protein
GFH48_RS11060	COG1940	carbohydrate kinase activity
GFH48_RS11065	COG0395	ABC-type sugar transport system, permease component
GFH48_RS11070	COG1175	transmembrane transport
GFH48_RS11075	COG1653	transport
GFH48_RS11085	COG3537	Alpha-1,2-mannosidase
GFH48_RS11090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFH48_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS11110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFH48_RS11150	COG1024	Enoyl-CoA hydratase
GFH48_RS11160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFH48_RS11165	COG2235	arginine
GFH48_RS11180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GFH48_RS11190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS11210	COG1799	cell septum assembly
GFH48_RS11215	COG0243	molybdopterin cofactor binding
GFH48_RS11255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH48_RS11260	COG0531	amino acid
GFH48_RS11270	COG0569	domain protein
GFH48_RS11305	COG1136	(ABC) transporter
GFH48_RS11320	COG0756	dUTP diphosphatase activity
GFH48_RS11345	COG2205	protein histidine kinase activity
GFH48_RS11350	COG0745	RESPONSE REGULATOR receiver
GFH48_RS11360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFH48_RS11395	COG1435	thymidine kinase activity
GFH48_RS11410	COG0045	succinate-CoA ligase (ADP-forming) activity
GFH48_RS11410	COG1042	CoA-binding domain protein
GFH48_RS11410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH48_RS11415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFH48_RS11420	COG1802	Transcriptional regulator
GFH48_RS11425	COG0739	heme binding
GFH48_RS11435	COG0612	Peptidase, M16
GFH48_RS11440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFH48_RS11445	COG0523	cobalamin synthesis protein
GFH48_RS11460	COG0372	Belongs to the citrate synthase family
GFH48_RS11475	COG3290	protein histidine kinase activity
GFH48_RS11480	COG4565	transcriptional regulatory protein
GFH48_RS11490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH48_RS11505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH48_RS11510	COG2197	response regulator
GFH48_RS11525	COG0187	DNA topoisomerase II activity
GFH48_RS11540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH48_RS11545	COG2186	Transcriptional regulator
GFH48_RS11585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFH48_RS11625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH48_RS11630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFH48_RS11635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GFH48_RS11670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFH48_RS11680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH48_RS11685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFH48_RS11695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFH48_RS11715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH48_RS11720	COG0583	DNA-binding transcription factor activity
GFH48_RS11730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFH48_RS11735	COG2197	response regulator
GFH48_RS11760	COG2358	TRAP transporter, solute receptor (TAXI family
GFH48_RS11765	COG2205	protein histidine kinase activity
GFH48_RS11770	COG0745	RESPONSE REGULATOR receiver
GFH48_RS11775	COG1126	abc transporter atp-binding protein
GFH48_RS11780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH48_RS11785	COG0765	amino acid transport
GFH48_RS11790	COG0765	amino acid transport
GFH48_RS11795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS11805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFH48_RS11815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFH48_RS11825	COG0628	permease
GFH48_RS11855	COG1201	RNA secondary structure unwinding
GFH48_RS11860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFH48_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS11870	COG0783	Belongs to the Dps family
GFH48_RS11875	COG1396	sequence-specific DNA binding
GFH48_RS11880	COG1546	Belongs to the CinA family
GFH48_RS11880	COG1058	Belongs to the CinA family
GFH48_RS11890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH48_RS11900	COG1674	ftsk spoiiie
GFH48_RS11910	COG4999	Histidine kinase
GFH48_RS11910	COG3850	Histidine kinase
GFH48_RS11910	COG2205	protein histidine kinase activity
GFH48_RS11910	COG3437	response regulator, receiver
GFH48_RS11915	COG2770	Histidine kinase
GFH48_RS11915	COG2208	phosphoserine phosphatase activity
GFH48_RS11945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFH48_RS11950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS11955	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GFH48_RS11975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFH48_RS11980	COG0612	Peptidase, M16
GFH48_RS11985	COG1185	polyribonucleotide nucleotidyltransferase activity
GFH48_RS11990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFH48_RS12005	COG1674	ftsk spoiiie
GFH48_RS12020	COG1404	Belongs to the peptidase S8 family
GFH48_RS12035	COG1404	Belongs to the peptidase S8 family
GFH48_RS12055	COG0455	bacterial-type flagellum organization
GFH48_RS12065	COG0601	transmembrane transport
GFH48_RS12080	COG4608	Belongs to the ABC transporter superfamily
GFH48_RS12095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFH48_RS12100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFH48_RS12110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFH48_RS12125	COG0779	Required for maturation of 30S ribosomal subunits
GFH48_RS12145	COG0442	prolyl-tRNA aminoacylation
GFH48_RS12160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFH48_RS12165	COG0750	zinc metalloprotease
GFH48_RS12170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFH48_RS12195	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS12230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH48_RS12235	COG1177	transmembrane transport
GFH48_RS12240	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFH48_RS12245	COG3842	ATPase activity
GFH48_RS12270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH48_RS12275	COG0584	glycerophosphoryl diester phosphodiesterase
GFH48_RS12280	COG1595	DNA-templated transcription, initiation
GFH48_RS12320	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS12330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFH48_RS12335	COG1136	(ABC) transporter
GFH48_RS12360	COG3842	ATPase activity
GFH48_RS12365	COG4208	sulfate ABC transporter
GFH48_RS12375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFH48_RS12380	COG0575	Belongs to the CDS family
GFH48_RS12385	COG0233	cytoplasmic translational termination
GFH48_RS12390	COG0528	UMP kinase activity
GFH48_RS12395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFH48_RS12400	COG0052	Belongs to the universal ribosomal protein uS2 family
GFH48_RS12415	COG1191	sigma factor activity
GFH48_RS12430	COG4974	Belongs to the 'phage' integrase family
GFH48_RS12445	COG0515	serine threonine protein kinase
GFH48_RS12445	COG2815	serine threonine protein kinase
GFH48_RS12510	COG2154	pterin-4-alpha-carbinolamine dehydratase
GFH48_RS12600	COG0305	Participates in initiation and elongation during chromosome replication
GFH48_RS12645	COG0792	nuclease activity
GFH48_RS12655	COG1051	belongs to the nudix hydrolase family
GFH48_RS12670	COG0681	Belongs to the peptidase S26 family
GFH48_RS12680	COG0335	large ribosomal subunit rRNA binding
GFH48_RS12685	COG0336	Belongs to the RNA methyltransferase TrmD family
GFH48_RS12690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFH48_RS12695	COG1837	Belongs to the UPF0109 family
GFH48_RS12700	COG0228	four-way junction DNA binding
GFH48_RS12710	COG0442	prolyl-tRNA aminoacylation
GFH48_RS12720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH48_RS12730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GFH48_RS12770	COG0477	Major facilitator Superfamily
GFH48_RS12785	COG1254	Belongs to the acylphosphatase family
GFH48_RS12790	COG2340	Cysteine-rich secretory protein family
GFH48_RS12820	COG2188	Transcriptional regulator
GFH48_RS12845	COG1733	regulation of RNA biosynthetic process
GFH48_RS12850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFH48_RS12855	COG0571	ribonuclease III activity
GFH48_RS12860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFH48_RS12875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFH48_RS12880	COG0742	ribosomal rna small subunit methyltransferase
GFH48_RS12890	COG0326	Molecular chaperone. Has ATPase activity
GFH48_RS12900	COG1461	Dihydroxyacetone kinase
GFH48_RS12905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFH48_RS12925	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFH48_RS12930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFH48_RS12940	COG1920	GTP binding
GFH48_RS12950	COG0776	regulation of translation
GFH48_RS12960	COG0066	3-isopropylmalate dehydratase activity
GFH48_RS12965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFH48_RS12970	COG1414	Transcriptional regulator
GFH48_RS13020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH48_RS13025	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH48_RS13035	COG5002	protein histidine kinase activity
GFH48_RS13040	COG2018	Roadblock/LC7 domain
GFH48_RS13060	COG2018	Roadblock/LC7 domain
GFH48_RS13080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH48_RS13110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH48_RS13120	COG2957	Belongs to the agmatine deiminase family
GFH48_RS13125	COG0804	urea catabolic process
GFH48_RS13140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFH48_RS13145	COG0473	3-isopropylmalate dehydrogenase activity
GFH48_RS13160	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS13165	COG0506	proline dehydrogenase activity
GFH48_RS13180	COG0477	Major facilitator Superfamily
GFH48_RS13185	COG1672	PFAM Archaeal ATPase
GFH48_RS13185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH48_RS13190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH48_RS13195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFH48_RS13200	COG0440	acetolactate synthase activity
GFH48_RS13220	COG0667	Aldo Keto reductase
GFH48_RS13225	COG2133	pyrroloquinoline quinone binding
GFH48_RS13235	COG2197	response regulator
GFH48_RS13250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH48_RS13255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFH48_RS13265	COG0154	amidase activity
GFH48_RS13270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFH48_RS13280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH48_RS13290	COG4221	oxidoreductase activity
GFH48_RS13295	COG1611	Belongs to the LOG family
GFH48_RS13310	COG0482	sulfurtransferase activity
GFH48_RS13345	COG2860	membrane
GFH48_RS13360	COG4608	Belongs to the ABC transporter superfamily
GFH48_RS13365	COG0444	Belongs to the ABC transporter superfamily
GFH48_RS13380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS13400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFH48_RS13405	COG0509	glycine decarboxylation via glycine cleavage system
GFH48_RS13410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFH48_RS13415	COG1760	l-serine dehydratase
GFH48_RS13440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH48_RS13470	COG1376	ErfK ybiS ycfS ynhG family protein
GFH48_RS13475	COG1376	ErfK ybiS ycfS ynhG family protein
GFH48_RS13485	COG2197	response regulator
GFH48_RS13490	COG4585	Histidine kinase
GFH48_RS13500	COG1131	(ABC) transporter
GFH48_RS13505	COG1132	(ABC) transporter
GFH48_RS13510	COG1132	(ABC) transporter
GFH48_RS13515	COG1132	(ABC) transporter
GFH48_RS13520	COG1132	(ABC) transporter
GFH48_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS13525	COG0604	alcohol dehydrogenase
GFH48_RS13525	COG3321	synthase
GFH48_RS13545	COG0058	SHG alpha-glucan phosphorylase activity
GFH48_RS13555	COG0366	Alpha amylase catalytic
GFH48_RS13565	COG3281	Trehalose synthase
GFH48_RS13570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFH48_RS13580	COG3118	belongs to the thioredoxin family
GFH48_RS13580	COG0492	ferredoxin-NADP+ reductase activity
GFH48_RS13605	COG1301	dicarboxylic acid transport
GFH48_RS13610	COG3290	protein histidine kinase activity
GFH48_RS13615	COG4565	transcriptional regulatory protein
GFH48_RS13625	COG1175	transmembrane transport
GFH48_RS13630	COG0395	ABC-type sugar transport system, permease component
GFH48_RS13640	COG0205	6-phosphofructokinase activity
GFH48_RS13645	COG0280	phosphate acetyltransferase
GFH48_RS13645	COG0857	belongs to the CobB CobQ family
GFH48_RS13650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFH48_RS13685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS13685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS13735	COG0745	RESPONSE REGULATOR receiver
GFH48_RS13750	COG0183	Belongs to the thiolase family
GFH48_RS13770	COG1131	(ABC) transporter
GFH48_RS13815	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GFH48_RS13830	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS13855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFH48_RS13860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFH48_RS13865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFH48_RS13870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFH48_RS13875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH48_RS13880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFH48_RS13885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH48_RS13900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH48_RS13905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFH48_RS13910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH48_RS13920	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH48_RS13925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFH48_RS13930	COG0254	rRNA binding
GFH48_RS13945	COG0083	homoserine kinase activity
GFH48_RS13950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFH48_RS13955	COG0460	homoserine dehydrogenase
GFH48_RS13960	COG0019	diaminopimelate decarboxylase activity
GFH48_RS13965	COG0018	arginyl-trna synthetase
GFH48_RS14010	COG0270	DNA (cytosine-5-)-methyltransferase activity
GFH48_RS14030	COG1674	ftsk spoiiie
GFH48_RS14075	COG1609	Transcriptional regulator
GFH48_RS14085	COG3629	intracellular signal transduction
GFH48_RS14085	COG3903	Transcriptional regulator
GFH48_RS14145	COG2188	Transcriptional regulator
GFH48_RS14150	COG2172	sigma factor antagonist activity
GFH48_RS14155	COG2188	Transcriptional regulator
GFH48_RS14235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFH48_RS14265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GFH48_RS14275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH48_RS14295	COG2205	protein histidine kinase activity
GFH48_RS14300	COG0772	Belongs to the SEDS family
GFH48_RS14305	COG0768	penicillin binding
GFH48_RS14310	COG0701	Predicted permease
GFH48_RS14350	COG2132	Multicopper oxidase
GFH48_RS14390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFH48_RS14405	COG0745	RESPONSE REGULATOR receiver
GFH48_RS14410	COG2205	protein histidine kinase activity
GFH48_RS14415	COG0567	Dehydrogenase, E1 component
GFH48_RS14415	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH48_RS14445	COG0604	alcohol dehydrogenase
GFH48_RS14450	COG0281	malic enzyme
GFH48_RS14465	COG1126	abc transporter atp-binding protein
GFH48_RS14470	COG4106	trans-aconitate 2-methyltransferase activity
GFH48_RS14480	COG0681	Belongs to the peptidase S26 family
GFH48_RS14545	COG3619	membrane
GFH48_RS14555	COG0456	acetyltransferase
GFH48_RS14560	COG0142	geranyltranstransferase activity
GFH48_RS14565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFH48_RS14580	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GFH48_RS14610	COG1597	lipid kinase activity
GFH48_RS14625	COG0363	glucosamine-6-phosphate deaminase activity
GFH48_RS14630	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH48_RS14635	COG0395	ABC-type sugar transport system, permease component
GFH48_RS14640	COG1175	transmembrane transport
GFH48_RS14645	COG2182	Extracellular solute-binding protein
GFH48_RS14650	COG2188	Transcriptional regulator
GFH48_RS14675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH48_RS14695	COG2124	cytochrome p450
GFH48_RS14705	COG0242	peptide deformylase activity
GFH48_RS14720	COG2199	diguanylate cyclase activity
GFH48_RS14720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GFH48_RS14725	COG5662	AntiSigma factor
GFH48_RS14730	COG1595	DNA-templated transcription, initiation
GFH48_RS14740	COG2135	peptidase activity
GFH48_RS14750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFH48_RS14760	COG2076	Multidrug Resistance protein
GFH48_RS14770	COG0483	inositol monophosphate 1-phosphatase activity
GFH48_RS14785	COG0753	catalase activity
GFH48_RS14810	COG1615	UPF0182 protein
GFH48_RS14820	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFH48_RS14875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFH48_RS14915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH48_RS14985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS14990	COG0747	negative chemotaxis
GFH48_RS15030	COG0513	Belongs to the DEAD box helicase family
GFH48_RS15040	COG1432	Conserved Protein
GFH48_RS15045	COG2095	MarC family integral membrane protein
GFH48_RS15070	COG0598	Magnesium transport protein CorA
GFH48_RS15080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GFH48_RS15105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH48_RS15110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH48_RS15120	COG1595	DNA-templated transcription, initiation
GFH48_RS15135	COG1024	Enoyl-CoA hydratase
GFH48_RS15140	COG2818	Glycosylase
GFH48_RS15160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH48_RS15195	COG2197	response regulator
GFH48_RS15200	COG4585	Histidine kinase
GFH48_RS15210	COG1131	(ABC) transporter
GFH48_RS15225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH48_RS15260	COG4608	Belongs to the ABC transporter superfamily
GFH48_RS15265	COG0444	Belongs to the ABC transporter superfamily
GFH48_RS15270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS15275	COG0601	transmembrane transport
GFH48_RS15285	COG4608	Belongs to the ABC transporter superfamily
GFH48_RS15290	COG0444	Belongs to the ABC transporter superfamily
GFH48_RS15295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH48_RS15300	COG0601	transmembrane transport
GFH48_RS15305	COG4166	transmembrane transport
GFH48_RS15310	COG1217	gtp-binding protein TYPA
GFH48_RS15330	COG1053	succinate dehydrogenase
GFH48_RS15395	COG0012	GTP binding
GFH48_RS15410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFH48_RS15415	COG1570	exodeoxyribonuclease VII activity
GFH48_RS15420	COG1722	exodeoxyribonuclease VII activity
GFH48_RS15425	COG0778	Nitroreductase
GFH48_RS15450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GFH48_RS15450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GFH48_RS15465	COG0114	fumarate hydratase activity
GFH48_RS15485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GFH48_RS15505	COG1136	(ABC) transporter
GFH48_RS15520	COG0450	alkyl hydroperoxide reductase
GFH48_RS15525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS15535	COG0741	lytic transglycosylase activity
GFH48_RS15540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GFH48_RS15545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH48_RS15550	COG0667	Aldo Keto reductase
GFH48_RS15565	COG2318	DinB family
GFH48_RS15600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH48_RS15605	COG2885	chlorophyll binding
GFH48_RS15625	COG2197	response regulator
GFH48_RS15655	COG2894	cell division
GFH48_RS15685	COG2610	gluconate transmembrane transporter activity
GFH48_RS15690	COG0251	oxidation-reduction process
GFH48_RS15695	COG1414	Transcriptional regulator
GFH48_RS15710	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GFH48_RS15720	COG0436	Aminotransferase
GFH48_RS15750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GFH48_RS15760	COG0477	Major facilitator Superfamily
GFH48_RS15765	COG1309	transcriptional regulator
GFH48_RS15795	COG1331	Highly conserved protein containing a thioredoxin domain
GFH48_RS15810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH48_RS15820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH48_RS15835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFH48_RS15840	COG2255	four-way junction helicase activity
GFH48_RS15865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH48_RS15880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFH48_RS15885	COG3173	Aminoglycoside phosphotransferase
GFH48_RS15890	COG1785	Belongs to the alkaline phosphatase family
GFH48_RS15910	COG1064	alcohol dehydrogenase
GFH48_RS15925	COG1404	Belongs to the peptidase S8 family
GFH48_RS15930	COG1136	(ABC) transporter
GFH48_RS15965	COG1278	Cold shock
GFH48_RS15970	COG2986	histidine ammonia-lyase
GFH48_RS15980	COG1024	Enoyl-CoA hydratase
GFH48_RS16000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH48_RS16020	COG0424	maF-like protein
GFH48_RS16030	COG4770	biotin carboxylase activity
GFH48_RS16055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH48_RS16065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH48_RS16075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFH48_RS16080	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS16085	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS16100	COG1595	DNA-templated transcription, initiation
GFH48_RS16105	COG0745	RESPONSE REGULATOR receiver
GFH48_RS16110	COG2205	protein histidine kinase activity
GFH48_RS16135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH48_RS16145	COG0583	DNA-binding transcription factor activity
GFH48_RS16150	COG2814	Major facilitator Superfamily
GFH48_RS16180	COG1079	Belongs to the binding-protein-dependent transport system permease family
GFH48_RS16190	COG3845	ABC transporter
GFH48_RS16195	COG1744	ABC transporter substrate-binding protein PnrA-like
GFH48_RS16205	COG1744	ABC transporter substrate-binding protein PnrA-like
GFH48_RS16210	COG1473	amidohydrolase
GFH48_RS16210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GFH48_RS16245	COG4195	phage-related replication protein
GFH48_RS16250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH48_RS16290	COG2089	acid synthase
GFH48_RS16305	COG1216	Glycosyl transferase, family 2
GFH48_RS16315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH48_RS16345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS16345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS16360	COG1595	DNA-templated transcription, initiation
GFH48_RS16370	COG1595	DNA-templated transcription, initiation
GFH48_RS16390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH48_RS16400	COG2009	succinate dehydrogenase
GFH48_RS16410	COG1053	succinate dehydrogenase
GFH48_RS16455	COG2409	Drug exporters of the RND superfamily
GFH48_RS16460	COG0745	RESPONSE REGULATOR receiver
GFH48_RS16465	COG2205	protein histidine kinase activity
GFH48_RS16475	COG1408	metallophosphoesterase
GFH48_RS16480	COG1686	Belongs to the peptidase S11 family
GFH48_RS16485	COG1295	ribonuclease BN
GFH48_RS16520	COG0180	Tryptophanyl-tRNA synthetase
GFH48_RS16540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFH48_RS16550	COG0754	glutathionylspermidine amidase activity
GFH48_RS16570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH48_RS16575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS16590	COG4175	Glycine betaine
GFH48_RS16590	COG0517	IMP dehydrogenase activity
GFH48_RS16600	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS16620	COG0039	L-malate dehydrogenase activity
GFH48_RS16640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFH48_RS16650	COG0138	bifunctional purine biosynthesis protein purh
GFH48_RS16680	COG0045	succinate-CoA ligase (ADP-forming) activity
GFH48_RS16685	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GFH48_RS16690	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GFH48_RS16695	COG0714	Associated with various cellular activities
GFH48_RS16710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS16710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH48_RS16720	COG0739	heme binding
GFH48_RS16755	COG2197	response regulator
GFH48_RS16800	COG0519	Catalyzes the synthesis of GMP from XMP
GFH48_RS16800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFH48_RS16825	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS16835	COG0515	serine threonine protein kinase
GFH48_RS16840	COG0515	serine threonine protein kinase
GFH48_RS16840	COG2815	serine threonine protein kinase
GFH48_RS16845	COG0515	serine threonine protein kinase
GFH48_RS16860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFH48_RS16875	COG0516	GMP reductase activity
GFH48_RS16885	COG1595	DNA-templated transcription, initiation
GFH48_RS16900	COG0583	DNA-binding transcription factor activity
GFH48_RS16910	COG4221	oxidoreductase activity
GFH48_RS16915	COG0459	protein refolding
GFH48_RS16920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFH48_RS16925	COG0726	polysaccharide deacetylase
GFH48_RS16940	COG4941	Belongs to the sigma-70 factor family
GFH48_RS16965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFH48_RS16990	COG0802	atpase or kinase
GFH48_RS17000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFH48_RS17015	COG0736	holo-[acyl-carrier-protein] synthase activity
GFH48_RS17030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH48_RS17035	COG1072	(Pantothenic acid kinase))
GFH48_RS17045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH48_RS17050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFH48_RS17055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFH48_RS17065	COG0101	tRNA pseudouridine synthase activity
GFH48_RS17070	COG0203	ribosomal protein L17
GFH48_RS17075	COG0202	RNA polymerase activity
GFH48_RS17080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFH48_RS17085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFH48_RS17090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFH48_RS17095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFH48_RS17105	COG0563	adenylate kinase activity
GFH48_RS17115	COG0200	Binds to the 23S rRNA
GFH48_RS17120	COG1841	ribosomal large subunit assembly
GFH48_RS17125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFH48_RS17130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFH48_RS17135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFH48_RS17140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFH48_RS17150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFH48_RS17155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFH48_RS17160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFH48_RS17165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFH48_RS17170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFH48_RS17175	COG0255	Belongs to the universal ribosomal protein uL29 family
GFH48_RS17180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFH48_RS17185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFH48_RS17190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFH48_RS17195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFH48_RS17200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFH48_RS17205	COG0089	rRNA binding
GFH48_RS17210	COG0088	Forms part of the polypeptide exit tunnel
GFH48_RS17215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFH48_RS17220	COG0051	transcription antitermination factor activity, RNA binding
GFH48_RS17245	COG1404	Belongs to the peptidase S8 family
GFH48_RS17260	COG2124	cytochrome p450
GFH48_RS17265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFH48_RS17270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFH48_RS17275	COG0049	tRNA binding
GFH48_RS17280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFH48_RS17290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFH48_RS17295	COG0085	RNA polymerase activity
GFH48_RS17300	COG0222	ribosome binding
GFH48_RS17305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFH48_RS17320	COG0081	regulation of translation
GFH48_RS17325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFH48_RS17345	COG0436	Aminotransferase
GFH48_RS17350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH48_RS17360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFH48_RS17365	COG0477	Major facilitator Superfamily
GFH48_RS17380	COG2030	dehydratase
GFH48_RS17385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFH48_RS17400	COG0402	S-adenosylhomocysteine deaminase activity
GFH48_RS17405	COG0702	epimerase
GFH48_RS17420	COG1666	GTP binding
GFH48_RS17425	COG2261	transglycosylase associated protein
GFH48_RS17435	COG3304	Inner membrane component domain
GFH48_RS17440	COG0501	Belongs to the peptidase M48B family
GFH48_RS17445	COG1007	ATP synthesis coupled electron transport
GFH48_RS17455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH48_RS17465	COG0839	Belongs to the complex I subunit 6 family
GFH48_RS17470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFH48_RS17480	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17510	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFH48_RS17510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFH48_RS17515	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFH48_RS17520	COG1733	regulation of RNA biosynthetic process
GFH48_RS17525	COG0702	epimerase
GFH48_RS17560	COG1131	(ABC) transporter
GFH48_RS17570	COG0142	geranyltranstransferase activity
GFH48_RS17585	COG0561	phosphatase activity
GFH48_RS17590	COG0492	ferredoxin-NADP+ reductase activity
GFH48_RS17605	COG0514	ATP-dependent DNA helicase (RecQ)
GFH48_RS17615	COG1007	ATP synthesis coupled electron transport
GFH48_RS17625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH48_RS17630	COG0713	ATP synthesis coupled electron transport
GFH48_RS17640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFH48_RS17650	COG1034	ATP synthesis coupled electron transport
GFH48_RS17655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GFH48_RS17665	COG0649	NAD binding
GFH48_RS17670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH48_RS17705	COG2226	methyltransferase
GFH48_RS17730	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH48_RS17745	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GFH48_RS17750	COG1278	Cold shock
GFH48_RS17765	COG1309	transcriptional regulator
GFH48_RS17780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH48_RS17790	COG0163	prenyltransferase activity
GFH48_RS17800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GFH48_RS17840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFH48_RS17845	COG1333	cytochrome c biogenesis protein
GFH48_RS17865	COG0406	alpha-ribazole phosphatase activity
GFH48_RS17870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFH48_RS17880	COG0531	amino acid
GFH48_RS17905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GFH48_RS17910	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GFH48_RS17915	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GFH48_RS17925	COG0531	amino acid
GFH48_RS17935	COG0531	amino acid
GFH48_RS17960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS17970	COG1742	UPF0060 membrane protein
GFH48_RS17980	COG1690	Belongs to the RtcB family
GFH48_RS18000	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GFH48_RS18005	COG0018	arginyl-trna synthetase
GFH48_RS18030	COG0113	porphobilinogen synthase activity
GFH48_RS18035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFH48_RS18035	COG1648	precorrin-2 dehydrogenase activity
GFH48_RS18040	COG0181	hydroxymethylbilane synthase activity
GFH48_RS18045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFH48_RS18050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFH48_RS18100	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFH48_RS18135	COG0180	Tryptophanyl-tRNA synthetase
GFH48_RS18140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFH48_RS18150	COG1129	ABC transporter
GFH48_RS18150	COG0842	Transport permease protein
GFH48_RS18160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH48_RS18170	COG4991	sh3 domain protein
GFH48_RS18175	COG0515	serine threonine protein kinase
GFH48_RS18175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFH48_RS18180	COG0129	dihydroxy-acid dehydratase activity
GFH48_RS18185	COG1309	transcriptional regulator
GFH48_RS18190	COG1082	Xylose isomerase domain protein TIM barrel
GFH48_RS18195	COG0248	Ppx GppA phosphatase
GFH48_RS18215	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GFH48_RS18230	COG1595	DNA-templated transcription, initiation
GFH48_RS18240	COG0745	RESPONSE REGULATOR receiver
GFH48_RS18245	COG2205	protein histidine kinase activity
GFH48_RS18250	COG0477	Major facilitator Superfamily
GFH48_RS18260	COG0739	heme binding
GFH48_RS18290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GFH48_RS18310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFH48_RS18320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFH48_RS18325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFH48_RS18350	COG2197	response regulator
GFH48_RS18365	COG0649	NAD binding
GFH48_RS18390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFH48_RS18390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFH48_RS18405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GFH48_RS18420	COG0302	gtp cyclohydrolase
GFH48_RS18435	COG0037	tRNA processing
GFH48_RS18445	COG2027	D-alanyl-D-alanine carboxypeptidase
GFH48_RS18450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GFH48_RS18465	COG0789	Transcriptional regulator
GFH48_RS18475	COG0076	glutamate decarboxylase activity
GFH48_RS18485	COG2318	DinB family
GFH48_RS18490	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS18530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH48_RS18530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH48_RS18565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFH48_RS18570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFH48_RS18575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFH48_RS18575	COG1754	DNA topoisomerase type I activity
GFH48_RS18595	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GFH48_RS18600	COG2172	sigma factor antagonist activity
GFH48_RS18605	COG1366	Belongs to the anti-sigma-factor antagonist family
GFH48_RS18610	COG1205	dead DEAH box helicase
GFH48_RS18610	COG1111	helicase
GFH48_RS18695	COG0629	single-stranded DNA binding
GFH48_RS18925	COG0659	secondary active sulfate transmembrane transporter activity
GFH48_RS18930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH48_RS18935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH48_RS18945	COG0596	Alpha beta hydrolase
GFH48_RS18975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH48_RS19000	COG0003	Pfam Anion-transporting ATPase
GFH48_RS19015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH48_RS19025	COG1408	metallophosphoesterase
GFH48_RS19055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFH48_RS19065	COG2843	Capsule synthesis protein
GFH48_RS19095	COG1595	DNA-templated transcription, initiation
GFH48_RS19115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFH48_RS19120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFH48_RS19130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFH48_RS19140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFH48_RS19145	COG1802	Transcriptional regulator
GFH48_RS19150	COG0463	Glycosyl transferase, family 2
GFH48_RS19170	COG0737	Belongs to the 5'-nucleotidase family
GFH48_RS19175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFH48_RS19190	COG1131	(ABC) transporter
GFH48_RS19195	COG3559	Exporter of polyketide antibiotics
GFH48_RS19205	COG2197	response regulator
GFH48_RS19210	COG4585	Histidine kinase
GFH48_RS19225	COG3844	kynureninase activity
GFH48_RS19240	COG0477	Major facilitator Superfamily
GFH48_RS19245	COG0191	fructose-bisphosphate aldolase activity
GFH48_RS19250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFH48_RS19255	COG2017	converts alpha-aldose to the beta-anomer
GFH48_RS19265	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GFH48_RS19300	COG0542	response to heat
GFH48_RS19330	COG4213	ABC transporter substrate-binding protein
GFH48_RS19335	COG0789	Transcriptional regulator
GFH48_RS19340	COG0484	heat shock protein binding
GFH48_RS19345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFH48_RS19350	COG0443	Heat shock 70 kDa protein
GFH48_RS19355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH48_RS19360	COG2181	nitrate reductase activity
GFH48_RS19360	COG0247	lactate metabolic process
GFH48_RS19380	COG1672	PFAM Archaeal ATPase
GFH48_RS19380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH48_RS19405	COG0717	Belongs to the dCTP deaminase family
GFH48_RS19445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFH48_RS19445	COG0515	serine threonine protein kinase
GFH48_RS19475	COG1595	DNA-templated transcription, initiation
GFH48_RS19525	COG0725	ABC transporter, periplasmic molybdate-binding protein
GFH48_RS19560	COG1278	Cold shock
GFH48_RS19575	COG0222	ribosome binding
GFH48_RS19585	COG2267	carboxylic ester hydrolase activity
GFH48_RS19610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH48_RS19625	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GFH48_RS19685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH48_RS19690	COG2267	carboxylic ester hydrolase activity
GFH48_RS19700	COG1289	transmembrane transporter activity
GFH48_RS19710	COG0583	DNA-binding transcription factor activity
GFH48_RS19720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH48_RS19735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFH48_RS19750	COG1741	Belongs to the pirin family
GFH48_RS19760	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS19765	COG1362	aminopeptidase activity
GFH48_RS19825	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH48_RS19830	COG0022	dehydrogenase e1 component
GFH48_RS19855	COG0515	serine threonine protein kinase
GFH48_RS19860	COG0515	serine threonine protein kinase
GFH48_RS19880	COG0604	alcohol dehydrogenase
GFH48_RS19880	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS19880	COG3321	synthase
GFH48_RS19925	COG1522	sequence-specific DNA binding
GFH48_RS19930	COG1309	transcriptional regulator
GFH48_RS19935	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS19960	COG3396	Phenylacetate-CoA oxygenase
GFH48_RS19965	COG3460	Phenylacetate-CoA oxygenase
GFH48_RS19970	COG3396	Phenylacetate-CoA oxygenase
GFH48_RS19975	COG2151	metal-sulfur cluster biosynthetic enzyme
GFH48_RS19980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFH48_RS20005	COG1733	regulation of RNA biosynthetic process
GFH48_RS20010	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GFH48_RS20015	COG0702	epimerase
GFH48_RS20030	COG0277	FAD linked oxidase domain protein
GFH48_RS20050	COG0477	Major facilitator Superfamily
GFH48_RS20055	COG1733	regulation of RNA biosynthetic process
GFH48_RS20065	COG0475	glutathione-regulated potassium exporter activity
GFH48_RS20095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH48_RS20140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH48_RS20155	COG4770	biotin carboxylase activity
GFH48_RS20170	COG0745	RESPONSE REGULATOR receiver
GFH48_RS20200	COG1716	ATPase activity
GFH48_RS20205	COG1716	ATPase activity
GFH48_RS20225	COG0515	serine threonine protein kinase
GFH48_RS20230	COG3764	Sortase (surface protein transpeptidase)
GFH48_RS20235	COG3764	Sortase (surface protein transpeptidase)
GFH48_RS20255	COG3764	Sortase (surface protein transpeptidase)
GFH48_RS20270	COG0705	Rhomboid family
GFH48_RS20295	COG0515	serine threonine protein kinase
GFH48_RS20325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFH48_RS20330	COG0187	DNA topoisomerase II activity
GFH48_RS20335	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GFH48_RS20340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFH48_RS20345	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GFH48_RS20350	COG0592	DNA-directed DNA polymerase activity
GFH48_RS20355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH48_RS20360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFH48_RS20365	COG0594	ribonuclease P activity
GFH48_RS20370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFH48_RS20375	COG0706	membrane insertase activity
GFH48_RS20385	COG0357	Ribosomal RNA small subunit methyltransferase G
GFH48_RS20390	COG1192	Involved in chromosome partitioning
GFH48_RS20405	COG3118	belongs to the thioredoxin family
GFH48_RS20410	COG0492	ferredoxin-NADP+ reductase activity
GFH48_RS20420	COG1595	DNA-templated transcription, initiation
GFH48_RS20440	COG0617	tRNA 3'-terminal CCA addition
GFH48_RS20465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH48_RS20490	COG0360	Binds together with S18 to 16S ribosomal RNA
GFH48_RS20495	COG0629	single-stranded DNA binding
GFH48_RS20500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFH48_RS20505	COG0359	binds to the 23S rRNA
GFH48_RS20515	COG0305	Participates in initiation and elongation during chromosome replication
GFH48_RS20535	COG2814	Major facilitator Superfamily
GFH48_RS20570	COG0626	cystathionine gamma-synthase activity
GFH48_RS20575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH48_RS20580	COG1950	PFAM Membrane protein of
GFH48_RS20585	COG0662	Cupin 2, conserved barrel domain protein
GFH48_RS20610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GFH48_RS20625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GFH48_RS20630	COG1609	Transcriptional regulator
GFH48_RS20635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH48_RS20640	COG1271	oxidase subunit
GFH48_RS20645	COG1294	oxidase, subunit
GFH48_RS20650	COG4988	ABC transporter
GFH48_RS20660	COG0561	phosphatase activity
GFH48_RS20670	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GFH48_RS20675	COG0789	Transcriptional regulator
GFH48_RS20695	COG1131	(ABC) transporter
GFH48_RS20725	COG0561	phosphatase activity
GFH48_RS20730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFH48_RS20740	COG2837	iron assimilation
GFH48_RS20785	COG0006	proline dipeptidase activity
GFH48_RS20820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH48_RS20855	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS20880	COG1595	DNA-templated transcription, initiation
GFH48_RS20885	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS20935	COG0745	RESPONSE REGULATOR receiver
GFH48_RS20940	COG2205	protein histidine kinase activity
GFH48_RS20950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GFH48_RS20955	COG0477	Major facilitator Superfamily
GFH48_RS20965	COG3467	pyridoxamine 5'-phosphate
GFH48_RS20970	COG2353	YceI-like domain
GFH48_RS20995	COG1191	sigma factor activity
GFH48_RS21000	COG1191	sigma factor activity
GFH48_RS21035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFH48_RS21050	COG0433	COG0433 Predicted ATPase
GFH48_RS21095	COG0156	8-amino-7-oxononanoate synthase activity
GFH48_RS21105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH48_RS21110	COG0300	oxidoreductase activity
GFH48_RS21155	COG0151	Belongs to the GarS family
GFH48_RS21170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFH48_RS21180	COG2197	response regulator
GFH48_RS21215	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFH48_RS21220	COG0047	phosphoribosylformylglycinamidine synthase activity
GFH48_RS21225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFH48_RS21245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFH48_RS21280	COG1643	Atp-dependent helicase
GFH48_RS21315	COG0513	Belongs to the DEAD box helicase family
GFH48_RS21335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH48_RS21345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH48_RS21345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH48_RS21365	COG0667	Aldo Keto reductase
GFH48_RS21375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFH48_RS21380	COG0579	oxidoreductase
GFH48_RS21410	COG1252	NADH dehydrogenase
GFH48_RS21495	COG1196	nuclear chromosome segregation
GFH48_RS21495	COG0741	lytic transglycosylase activity
GFH48_RS21495	COG0739	heme binding
GFH48_RS21500	COG0671	phosphoesterase, PA-phosphatase related
GFH48_RS21505	COG0277	FAD linked oxidase domain protein
GFH48_RS21520	COG1937	Protein conserved in bacteria
GFH48_RS21530	COG0306	phosphate transporter
GFH48_RS21535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH48_RS21555	COG0406	alpha-ribazole phosphatase activity
GFH48_RS21555	COG0494	nUDIX hydrolase
GFH48_RS21565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFH48_RS21580	COG1131	(ABC) transporter
GFH48_RS21585	COG1725	Transcriptional regulator
GFH48_RS21605	COG1131	(ABC) transporter
GFH48_RS21620	COG0456	acetyltransferase
GFH48_RS21625	COG0737	Belongs to the 5'-nucleotidase family
GFH48_RS21635	COG1132	(ABC) transporter
GFH48_RS21660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH48_RS21670	COG1609	Transcriptional regulator
GFH48_RS21675	COG0745	RESPONSE REGULATOR receiver
GFH48_RS21700	COG2897	thiosulfate sulfurtransferase activity
GFH48_RS21740	COG3485	protocatechuate 3,4-dioxygenase
GFH48_RS21745	COG0745	RESPONSE REGULATOR receiver
GFH48_RS21755	COG0354	folic acid binding
GFH48_RS21760	COG1490	D-aminoacyl-tRNA deacylase activity
GFH48_RS21775	COG4552	Acetyltransferase involved in intracellular survival and related
GFH48_RS21785	COG2188	Transcriptional regulator
GFH48_RS21795	COG2188	Transcriptional regulator
GFH48_RS21800	COG0546	phosphoglycolate phosphatase activity
GFH48_RS21860	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS21890	COG0588	phosphoglycerate mutase activity
GFH48_RS21960	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS21965	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS21980	COG5002	protein histidine kinase activity
GFH48_RS22000	COG1329	Transcriptional regulator
GFH48_RS22005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GFH48_RS22010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFH48_RS22015	COG0215	cysteine-tRNA ligase activity
GFH48_RS22020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH48_RS22040	COG3842	ATPase activity
GFH48_RS22060	COG3903	Transcriptional regulator
GFH48_RS22060	COG3629	intracellular signal transduction
GFH48_RS22195	COG1105	Belongs to the carbohydrate kinase PfkB family
GFH48_RS22210	COG2182	Extracellular solute-binding protein
GFH48_RS22230	COG0463	Glycosyl transferase, family 2
GFH48_RS22250	COG0459	protein refolding
GFH48_RS22270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFH48_RS22275	COG1737	Transcriptional regulator
GFH48_RS22310	COG3973	AAA domain
GFH48_RS22330	COG1061	Type III restriction enzyme res subunit
GFH48_RS22355	COG1278	Cold shock
GFH48_RS22360	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GFH48_RS22365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFH48_RS22375	COG2814	Major facilitator Superfamily
GFH48_RS22400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFH48_RS22410	COG2252	PERMEase
GFH48_RS22420	COG1846	Transcriptional regulator
GFH48_RS22440	COG0667	Aldo Keto reductase
GFH48_RS22455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFH48_RS22465	COG2124	cytochrome p450
GFH48_RS22490	COG0277	FAD linked oxidase domain protein
GFH48_RS22490	COG0247	lactate metabolic process
GFH48_RS22520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH48_RS22535	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS22550	COG0259	pyridoxamine-phosphate oxidase activity
GFH48_RS22570	COG4821	SIS domain
GFH48_RS22580	COG0596	Alpha beta hydrolase
GFH48_RS22580	COG2945	thiolester hydrolase activity
GFH48_RS22630	COG1595	DNA-templated transcription, initiation
GFH48_RS22645	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS22655	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS22660	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS22675	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS22680	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS22715	COG1024	Enoyl-CoA hydratase
GFH48_RS22725	COG2072	flavoprotein involved in K transport
GFH48_RS22750	COG0259	pyridoxamine-phosphate oxidase activity
GFH48_RS22765	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS22775	COG1309	transcriptional regulator
GFH48_RS22790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFH48_RS22790	COG0515	serine threonine protein kinase
GFH48_RS22800	COG1024	Enoyl-CoA hydratase
GFH48_RS22865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GFH48_RS22875	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS22880	COG4221	oxidoreductase activity
GFH48_RS22900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH48_RS22950	COG1686	Belongs to the peptidase S11 family
GFH48_RS22965	COG0386	Belongs to the glutathione peroxidase family
GFH48_RS23005	COG1280	lysine exporter protein (LysE YggA)
GFH48_RS23055	COG1846	Transcriptional regulator
GFH48_RS23060	COG3384	dioxygenase
GFH48_RS23065	COG1247	-acetyltransferase
GFH48_RS23090	COG1349	DNA-binding transcription factor activity
GFH48_RS23100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFH48_RS23100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFH48_RS23100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFH48_RS23135	COG1970	mechanosensitive ion channel activity
GFH48_RS23145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFH48_RS23155	COG0477	Major facilitator Superfamily
GFH48_RS23170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFH48_RS23175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFH48_RS23185	COG0315	cyclic pyranopterin monophosphate synthase activity
GFH48_RS23190	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFH48_RS23190	COG0315	cyclic pyranopterin monophosphate synthase activity
GFH48_RS23195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH48_RS23225	COG2072	flavoprotein involved in K transport
GFH48_RS23230	COG2267	carboxylic ester hydrolase activity
GFH48_RS23235	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS23245	COG0793	Belongs to the peptidase S41A family
GFH48_RS23245	COG4946	Tricorn protease homolog
GFH48_RS23255	COG2409	Drug exporters of the RND superfamily
GFH48_RS23265	COG0310	cobalt ion transport
GFH48_RS23275	COG1122	ATPase activity
GFH48_RS23280	COG1764	response to oxidative stress
GFH48_RS23285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFH48_RS23350	COG0084	hydrolase, TatD family'
GFH48_RS23360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH48_RS23365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFH48_RS23375	COG0488	(ABC) transporter
GFH48_RS23415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFH48_RS23425	COG2197	response regulator
GFH48_RS23435	COG4106	trans-aconitate 2-methyltransferase activity
GFH48_RS23455	COG1309	transcriptional regulator
GFH48_RS23465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFH48_RS23475	COG0193	aminoacyl-tRNA hydrolase activity
GFH48_RS23480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFH48_RS23485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFH48_RS23490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFH48_RS23500	COG4585	Histidine kinase
GFH48_RS23530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH48_RS23540	COG0477	Major facilitator Superfamily
GFH48_RS23545	COG1136	(ABC) transporter
GFH48_RS23550	COG0577	efflux transmembrane transporter activity
GFH48_RS23645	COG2124	cytochrome p450
GFH48_RS23660	COG0148	phosphopyruvate hydratase activity
GFH48_RS23680	COG1252	NADH dehydrogenase
GFH48_RS23685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFH48_RS23690	COG0577	efflux transmembrane transporter activity
GFH48_RS23695	COG0577	efflux transmembrane transporter activity
GFH48_RS23695	COG1136	(ABC) transporter
GFH48_RS23730	COG0183	Belongs to the thiolase family
GFH48_RS23735	COG2755	lipolytic protein G-D-S-L family
GFH48_RS23760	COG1609	Transcriptional regulator
GFH48_RS23770	COG1174	glycine betaine transport
GFH48_RS23775	COG1174	glycine betaine transport
GFH48_RS23785	COG2986	histidine ammonia-lyase
GFH48_RS23825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFH48_RS23830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH48_RS23840	COG1228	amidohydrolase
GFH48_RS23850	COG1191	sigma factor activity
GFH48_RS23855	COG1366	Belongs to the anti-sigma-factor antagonist family
GFH48_RS23885	COG3104	oligopeptide transport
GFH48_RS23890	COG0745	RESPONSE REGULATOR receiver
GFH48_RS23895	COG2205	protein histidine kinase activity
GFH48_RS23910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFH48_RS23950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH48_RS23960	COG1011	Hydrolase
GFH48_RS23970	COG1316	TRANSCRIPTIONal
GFH48_RS23975	COG1316	TRANSCRIPTIONal
GFH48_RS23985	COG1316	TRANSCRIPTIONal
GFH48_RS23990	COG1316	TRANSCRIPTIONal
GFH48_RS23995	COG1316	TRANSCRIPTIONal
GFH48_RS24020	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GFH48_RS24020	COG0778	Nitroreductase
GFH48_RS24025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFH48_RS24060	COG1620	l-lactate permease
GFH48_RS24065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH48_RS24070	COG2835	tetraacyldisaccharide 4'-kinase activity
GFH48_RS24080	COG1482	cell wall glycoprotein biosynthetic process
GFH48_RS24090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFH48_RS24130	COG0714	Associated with various cellular activities
GFH48_RS24150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFH48_RS24155	COG0745	RESPONSE REGULATOR receiver
GFH48_RS24160	COG5002	protein histidine kinase activity
GFH48_RS24160	COG5000	phosphorelay sensor kinase activity
GFH48_RS24165	COG0823	Involved in the tonB-independent uptake of proteins
GFH48_RS24175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GFH48_RS24180	COG2197	response regulator
GFH48_RS24185	COG3214	Protein conserved in bacteria
GFH48_RS24195	COG0653	protein targeting
GFH48_RS24220	COG2902	Dehydrogenase
GFH48_RS24230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFH48_RS24230	COG0463	Glycosyl transferase, family 2
GFH48_RS24235	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS24240	COG1134	teichoic acid transport
GFH48_RS24295	COG1846	Transcriptional regulator
GFH48_RS24300	COG1764	response to oxidative stress
GFH48_RS24315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFH48_RS24320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFH48_RS24320	COG0463	Glycosyl transferase, family 2
GFH48_RS24325	COG0395	ABC-type sugar transport system, permease component
GFH48_RS24330	COG1175	transmembrane transport
GFH48_RS24345	COG0515	serine threonine protein kinase
GFH48_RS24350	COG0515	serine threonine protein kinase
GFH48_RS24355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GFH48_RS24370	COG2884	Cell division ATP-binding protein ftsE
GFH48_RS24380	COG0793	Belongs to the peptidase S41A family
GFH48_RS24385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFH48_RS24400	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH48_RS24405	COG0395	ABC-type sugar transport system, permease component
GFH48_RS24410	COG1175	transmembrane transport
GFH48_RS24425	COG0583	DNA-binding transcription factor activity
GFH48_RS24445	COG2223	nitrite transmembrane transporter activity
GFH48_RS24475	COG3973	AAA domain
GFH48_RS24485	COG0776	regulation of translation
GFH48_RS24490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFH48_RS24495	COG1678	Uncharacterized ACR, COG1678
GFH48_RS24510	COG1175	transmembrane transport
GFH48_RS24515	COG0395	ABC-type sugar transport system, permease component
GFH48_RS24520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH48_RS24570	COG3654	unkown
GFH48_RS24585	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFH48_RS24605	COG1174	glycine betaine transport
GFH48_RS24610	COG1125	glycine betaine transport
GFH48_RS24610	COG0517	IMP dehydrogenase activity
GFH48_RS24615	COG1174	glycine betaine transport
GFH48_RS24625	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GFH48_RS24635	COG0277	FAD linked oxidase domain protein
GFH48_RS24670	COG1335	isochorismatase
GFH48_RS24680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFH48_RS24690	COG1113	amino acid transport
GFH48_RS24720	COG1263	PTS System
GFH48_RS24725	COG1263	PTS System
GFH48_RS24730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFH48_RS24735	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFH48_RS24745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFH48_RS24780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH48_RS24810	COG2733	membrane
GFH48_RS24815	COG2814	Major facilitator Superfamily
GFH48_RS24815	COG0477	Major facilitator Superfamily
GFH48_RS24930	COG3764	Sortase (surface protein transpeptidase)
GFH48_RS24940	COG0706	membrane insertase activity
GFH48_RS24940	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
GFH48_RS24945	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH48_RS24950	COG4702	Belongs to the UPF0303 family
GFH48_RS24955	COG0673	inositol 2-dehydrogenase activity
GFH48_RS24960	COG1940	carbohydrate kinase activity
GFH48_RS24975	COG2188	Transcriptional regulator
GFH48_RS24980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH48_RS25055	COG3397	chitin binding
GFH48_RS25065	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS25070	COG1362	aminopeptidase activity
GFH48_RS25085	COG1126	abc transporter atp-binding protein
GFH48_RS25090	COG0765	amino acid transport
GFH48_RS25095	COG0765	amino acid transport
GFH48_RS25100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH48_RS25115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH48_RS25130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS25185	COG0406	alpha-ribazole phosphatase activity
GFH48_RS25220	COG3979	chitinase
GFH48_RS25265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GFH48_RS25270	COG4977	sequence-specific DNA binding
GFH48_RS25290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH48_RS25325	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GFH48_RS25345	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS25360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH48_RS25365	COG1309	transcriptional regulator
GFH48_RS25375	COG1946	Acyl-CoA thioesterase
GFH48_RS25405	COG0028	Belongs to the TPP enzyme family
GFH48_RS25415	COG2356	endonuclease I
GFH48_RS25450	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH48_RS25460	COG0181	hydroxymethylbilane synthase activity
GFH48_RS25470	COG1846	Transcriptional regulator
GFH48_RS25470	COG0456	acetyltransferase
GFH48_RS25480	COG1609	Transcriptional regulator
GFH48_RS25485	COG0673	inositol 2-dehydrogenase activity
GFH48_RS25520	COG1869	D-ribose catabolic process
GFH48_RS25525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH48_RS25535	COG1129	ABC transporter
GFH48_RS25540	COG1609	Transcriptional regulator
GFH48_RS25560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH48_RS25605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH48_RS25615	COG3718	enzyme involved in inositol metabolism
GFH48_RS25620	COG3962	Belongs to the TPP enzyme family
GFH48_RS25705	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS25725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFH48_RS25770	COG2304	oxidoreductase activity
GFH48_RS25785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH48_RS25815	COG0629	single-stranded DNA binding
GFH48_RS25840	COG1404	Belongs to the peptidase S8 family
GFH48_RS25880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFH48_RS25910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH48_RS25925	COG1486	melibiose metabolic process
GFH48_RS25930	COG0395	ABC-type sugar transport system, permease component
GFH48_RS25935	COG1175	transmembrane transport
GFH48_RS25950	COG0668	transmembrane transport
GFH48_RS25970	COG1131	(ABC) transporter
GFH48_RS25980	COG1595	DNA-templated transcription, initiation
GFH48_RS26005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS26030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFH48_RS26105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFH48_RS26125	COG1070	Carbohydrate kinase
GFH48_RS26130	COG0588	phosphoglycerate mutase activity
GFH48_RS26135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFH48_RS26140	COG1113	amino acid transport
GFH48_RS26160	COG1113	amino acid transport
GFH48_RS26175	COG4552	Acetyltransferase involved in intracellular survival and related
GFH48_RS26190	COG3594	Acyltransferase
GFH48_RS26210	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFH48_RS26215	COG0740	serine-type endopeptidase activity
GFH48_RS26220	COG0740	serine-type endopeptidase activity
GFH48_RS26225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFH48_RS26235	COG0525	valine-tRNA ligase activity
GFH48_RS26240	COG0285	dihydrofolate synthase activity
GFH48_RS26250	COG0105	UTP biosynthetic process
GFH48_RS26255	COG1077	Cell shape determining protein MreB Mrl
GFH48_RS26270	COG0768	penicillin binding
GFH48_RS26275	COG0772	Belongs to the SEDS family
GFH48_RS26295	COG0515	serine threonine protein kinase
GFH48_RS26370	COG2226	methyltransferase
GFH48_RS26375	COG0640	Transcriptional regulator
GFH48_RS26380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH48_RS26385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH48_RS26420	COG1530	ribonuclease E activity
GFH48_RS26425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFH48_RS26430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFH48_RS26435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFH48_RS26440	COG3540	Alkaline phosphatase
GFH48_RS26465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFH48_RS26475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFH48_RS26490	COG0501	Belongs to the peptidase M48B family
GFH48_RS26495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFH48_RS26505	COG0799	negative regulation of ribosome biogenesis
GFH48_RS26510	COG0588	phosphoglycerate mutase activity
GFH48_RS26555	COG0495	leucyl-tRNA aminoacylation
GFH48_RS26565	COG1307	EDD domain protein, DegV family
GFH48_RS26625	COG1234	tRNA 3'-trailer cleavage
GFH48_RS26645	COG0268	Binds directly to 16S ribosomal RNA
GFH48_RS26650	COG0481	GTPase activity
GFH48_RS26695	COG1420	regulation of RNA biosynthetic process
GFH48_RS26700	COG0484	heat shock protein binding
GFH48_RS26705	COG2070	2-Nitropropane dioxygenase
GFH48_RS26720	COG0793	Belongs to the peptidase S41A family
GFH48_RS26720	COG4946	Tricorn protease homolog
GFH48_RS26725	COG0537	adenosine 5'-monophosphoramidase activity
GFH48_RS26730	COG1234	tRNA 3'-trailer cleavage
GFH48_RS26735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH48_RS26755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFH48_RS26765	COG2315	Protein conserved in bacteria
GFH48_RS26775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFH48_RS26800	COG2723	6-phospho-beta-galactosidase activity
GFH48_RS26820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH48_RS26835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS26840	COG4608	Belongs to the ABC transporter superfamily
GFH48_RS26845	COG0444	Belongs to the ABC transporter superfamily
GFH48_RS26855	COG0747	negative chemotaxis
GFH48_RS26860	COG2186	Transcriptional regulator
GFH48_RS26875	COG1381	Involved in DNA repair and RecF pathway recombination
GFH48_RS26880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH48_RS26890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFH48_RS26895	COG1121	(ABC) transporter
GFH48_RS26905	COG0423	glycine-tRNA ligase activity
GFH48_RS26915	COG0667	Aldo Keto reductase
GFH48_RS26935	COG0477	Major facilitator Superfamily
GFH48_RS26975	COG1940	carbohydrate kinase activity
GFH48_RS26975	COG1846	Transcriptional regulator
GFH48_RS26980	COG0574	Belongs to the PEP-utilizing enzyme family
GFH48_RS26980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFH48_RS26990	COG1136	(ABC) transporter
GFH48_RS27010	COG2146	nitrite reductase [NAD(P)H] activity
GFH48_RS27010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFH48_RS27045	COG2949	membrane
GFH48_RS27055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GFH48_RS27065	COG0358	DNA primase activity
GFH48_RS27070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH48_RS27085	COG1070	Carbohydrate kinase
GFH48_RS27120	COG1077	Cell shape determining protein MreB Mrl
GFH48_RS27125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFH48_RS27125	COG0825	malonyl-CoA metabolic process
GFH48_RS27130	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS27155	COG1414	Transcriptional regulator
GFH48_RS27185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH48_RS27190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH48_RS27200	COG4214	carbohydrate transport
GFH48_RS27225	COG4948	Mandelate Racemase Muconate Lactonizing
GFH48_RS27235	COG2130	NADP-dependent
GFH48_RS27265	COG2084	Dehydrogenase
GFH48_RS27280	COG1309	transcriptional regulator
GFH48_RS27305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH48_RS27310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH48_RS27315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH48_RS27330	COG1741	Belongs to the pirin family
GFH48_RS27345	COG0789	Transcriptional regulator
GFH48_RS27350	COG0667	Aldo Keto reductase
GFH48_RS27365	COG1309	transcriptional regulator
GFH48_RS27370	COG0477	Major facilitator Superfamily
GFH48_RS27375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFH48_RS27380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GFH48_RS27425	COG1358	cellular component organization or biogenesis
GFH48_RS27440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH48_RS27680	COG1335	isochorismatase
GFH48_RS27685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFH48_RS27700	COG2259	Doxx family
GFH48_RS27765	COG4122	O-methyltransferase activity
GFH48_RS27780	COG2124	cytochrome p450
GFH48_RS27785	COG0183	Belongs to the thiolase family
GFH48_RS27795	COG3619	membrane
GFH48_RS27810	COG3845	ABC transporter
GFH48_RS27855	COG1309	transcriptional regulator
GFH48_RS27860	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS27885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS27905	COG0477	Major facilitator Superfamily
GFH48_RS27910	COG0183	Belongs to the thiolase family
GFH48_RS27920	COG2197	response regulator
GFH48_RS27925	COG4585	Histidine kinase
GFH48_RS27935	COG1131	(ABC) transporter
GFH48_RS27940	COG2030	dehydratase
GFH48_RS27950	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS27960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFH48_RS27975	COG0800	Aldolase
GFH48_RS27980	COG3022	response to hydroperoxide
GFH48_RS28110	COG0673	inositol 2-dehydrogenase activity
GFH48_RS28115	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS28130	COG0406	alpha-ribazole phosphatase activity
GFH48_RS28150	COG1136	(ABC) transporter
GFH48_RS28175	COG2814	Major facilitator Superfamily
GFH48_RS28180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFH48_RS28190	COG1834	amidinotransferase
GFH48_RS28200	COG0495	leucyl-tRNA aminoacylation
GFH48_RS28210	COG0672	)-iron permease
GFH48_RS28215	COG2837	iron assimilation
GFH48_RS28220	COG2822	iron ion transport
GFH48_RS28275	COG1994	Peptidase M50
GFH48_RS28295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFH48_RS28300	COG0477	Major facilitator Superfamily
GFH48_RS28315	COG2814	Major facilitator Superfamily
GFH48_RS28340	COG1959	2 iron, 2 sulfur cluster binding
GFH48_RS28345	COG1017	nitric oxide dioxygenase activity
GFH48_RS28345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFH48_RS28350	COG0174	glutamine synthetase
GFH48_RS28355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GFH48_RS28380	COG3511	phospholipase C
GFH48_RS28385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GFH48_RS28395	COG1609	Transcriptional regulator
GFH48_RS28405	COG1175	transmembrane transport
GFH48_RS28410	COG3833	ABC-type maltose transport systems, permease component
GFH48_RS28415	COG0366	Alpha amylase catalytic
GFH48_RS28440	COG1309	transcriptional regulator
GFH48_RS28480	COG0745	RESPONSE REGULATOR receiver
GFH48_RS28525	COG0501	Belongs to the peptidase M48B family
GFH48_RS28530	COG0174	glutamine synthetase
GFH48_RS28550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFH48_RS28555	COG0321	lipoyl(octanoyl) transferase activity
GFH48_RS28580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH48_RS28600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GFH48_RS28610	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH48_RS28615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH48_RS28620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFH48_RS28625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GFH48_RS28640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFH48_RS28640	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFH48_RS28645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GFH48_RS28665	COG2226	methyltransferase
GFH48_RS28685	COG4585	Histidine kinase
GFH48_RS28690	COG2197	response regulator
GFH48_RS28695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFH48_RS28700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFH48_RS28725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH48_RS28735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFH48_RS28740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFH48_RS28750	COG1376	ErfK ybiS ycfS ynhG family protein
GFH48_RS28760	COG1845	cytochrome c oxidase, subunit III
GFH48_RS28765	COG2010	Cytochrome c
GFH48_RS28770	COG0723	plastoquinol--plastocyanin reductase activity
GFH48_RS28775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFH48_RS28780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFH48_RS28785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFH48_RS28810	COG0791	NLP P60 protein
GFH48_RS28810	COG1388	LysM domain
GFH48_RS28810	COG3103	Sh3 type 3 domain protein
GFH48_RS28815	COG0791	NLP P60 protein
GFH48_RS28815	COG0741	lytic transglycosylase activity
GFH48_RS28855	COG0003	Pfam Anion-transporting ATPase
GFH48_RS28865	COG1940	carbohydrate kinase activity
GFH48_RS28890	COG4585	Histidine kinase
GFH48_RS28900	COG0205	6-phosphofructokinase activity
GFH48_RS28915	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GFH48_RS28925	COG2193	ferroxidase activity
GFH48_RS28930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFH48_RS28940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFH48_RS28945	COG2815	serine threonine protein kinase
GFH48_RS28945	COG0515	serine threonine protein kinase
GFH48_RS28950	COG2022	thiamine diphosphate biosynthetic process
GFH48_RS28960	COG2022	thiamine diphosphate biosynthetic process
GFH48_RS28960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH48_RS28985	COG0352	thiamine-phosphate diphosphorylase activity
GFH48_RS29010	COG1309	transcriptional regulator
GFH48_RS29015	COG1511	domain protein
GFH48_RS29020	COG1716	ATPase activity
GFH48_RS29020	COG1131	(ABC) transporter
GFH48_RS29020	COG0842	Transport permease protein
GFH48_RS29030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFH48_RS29050	COG0714	Associated with various cellular activities
GFH48_RS29060	COG0275	rRNA processing
GFH48_RS29075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFH48_RS29085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH48_RS29090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFH48_RS29100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFH48_RS29110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFH48_RS29115	COG1496	oxidoreductase activity
GFH48_RS29125	COG1799	cell septum assembly
GFH48_RS29135	COG3599	regulation of cell shape
GFH48_RS29140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFH48_RS29150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFH48_RS29200	COG0587	DNA-directed DNA polymerase activity
GFH48_RS29205	COG1432	Conserved Protein
GFH48_RS29225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFH48_RS29245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFH48_RS29250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH48_RS29255	COG0131	Imidazoleglycerol-phosphate dehydratase
GFH48_RS29260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFH48_RS29265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFH48_RS29270	COG0251	oxidation-reduction process
GFH48_RS29275	COG0107	imidazoleglycerol-phosphate synthase activity
GFH48_RS29285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFH48_RS29310	COG0134	indole-3-glycerol-phosphate synthase activity
GFH48_RS29320	COG0133	tryptophan synthase activity
GFH48_RS29325	COG0159	tryptophan synthase activity
GFH48_RS29340	COG2301	Belongs to the HpcH HpaI aldolase family
GFH48_RS29345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH48_RS29350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH48_RS29380	COG0070	glutamate synthase
GFH48_RS29380	COG0069	glutamate synthase activity
GFH48_RS29380	COG0067	glutamate synthase
GFH48_RS29415	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS29420	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS29425	COG1309	transcriptional regulator
GFH48_RS29430	COG0183	Belongs to the thiolase family
GFH48_RS29455	COG1024	Enoyl-CoA hydratase
GFH48_RS29465	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS29500	COG0287	Prephenate dehydrogenase
GFH48_RS29500	COG1605	Chorismate mutase
GFH48_RS29505	COG4566	intracellular signal transduction
GFH48_RS29525	COG0737	Belongs to the 5'-nucleotidase family
GFH48_RS29580	COG2050	protein possibly involved in aromatic compounds catabolism
GFH48_RS29620	COG1643	Atp-dependent helicase
GFH48_RS29625	COG2226	methyltransferase
GFH48_RS29645	COG0237	dephospho-CoA kinase activity
GFH48_RS29680	COG2267	carboxylic ester hydrolase activity
GFH48_RS29745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH48_RS29750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH48_RS29780	COG0598	Magnesium transport protein CorA
GFH48_RS29785	COG2226	methyltransferase
GFH48_RS29790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFH48_RS29790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GFH48_RS29800	COG2313	pseudouridylate synthase activity
GFH48_RS29810	COG1063	alcohol dehydrogenase
GFH48_RS29825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFH48_RS29830	COG0584	glycerophosphoryl diester phosphodiesterase
GFH48_RS29840	COG0556	nucleotide-excision repair
GFH48_RS29860	COG0387	Pfam Sodium calcium exchanger
GFH48_RS29865	COG0477	Major facilitator Superfamily
GFH48_RS29870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFH48_RS29880	COG0765	amino acid transport
GFH48_RS29890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH48_RS29900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFH48_RS29905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH48_RS29910	COG1609	Transcriptional regulator
GFH48_RS29925	COG0322	excinuclease ABC activity
GFH48_RS29930	COG1660	Displays ATPase and GTPase activities
GFH48_RS29935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFH48_RS29940	COG1481	regulation of sporulation
GFH48_RS29950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFH48_RS29955	COG0126	phosphoglycerate kinase activity
GFH48_RS29960	COG0149	triose-phosphate isomerase activity
GFH48_RS29965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFH48_RS29980	COG0166	Belongs to the GPI family
GFH48_RS29985	COG0363	glucosamine-6-phosphate deaminase activity
GFH48_RS30000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFH48_RS30010	COG0109	protoheme IX farnesyltransferase activity
GFH48_RS30025	COG1612	heme a metabolic process
GFH48_RS30040	COG2746	aminoglycoside 3-N-acetyltransferase activity
GFH48_RS30055	COG0719	Fe-S assembly protein
GFH48_RS30065	COG0396	ATPase activity
GFH48_RS30070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFH48_RS30075	COG0822	iron-sulfur transferase activity
GFH48_RS30090	COG2076	Multidrug Resistance protein
GFH48_RS30095	COG3226	Transcriptional regulator
GFH48_RS30100	COG2171	N-acyltransferase activity
GFH48_RS30115	COG1595	DNA-templated transcription, initiation
GFH48_RS30125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS30170	COG1309	transcriptional regulator
GFH48_RS30180	COG1063	alcohol dehydrogenase
GFH48_RS30185	COG0395	ABC-type sugar transport system, permease component
GFH48_RS30200	COG1349	DNA-binding transcription factor activity
GFH48_RS30205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH48_RS30210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS30230	COG1802	Transcriptional regulator
GFH48_RS30235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH48_RS30245	COG1175	transmembrane transport
GFH48_RS30250	COG0395	ABC-type sugar transport system, permease component
GFH48_RS30270	COG1653	transport
GFH48_RS30275	COG3866	Pectate lyase
GFH48_RS30290	COG2252	PERMEase
GFH48_RS30295	COG0768	penicillin binding
GFH48_RS30305	COG1414	Transcriptional regulator
GFH48_RS30335	COG5285	phytanoyl-CoA dioxygenase
GFH48_RS30340	COG1917	Cupin 2, conserved barrel domain protein
GFH48_RS30345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFH48_RS30350	COG0456	acetyltransferase
GFH48_RS30365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GFH48_RS30370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH48_RS30375	COG0765	amino acid transport
GFH48_RS30435	COG1797	cobyrinic acid a,c-diamide synthase activity
GFH48_RS30440	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GFH48_RS30455	COG1492	cobalamin metabolic process
GFH48_RS30460	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GFH48_RS30480	COG0235	Class ii aldolase
GFH48_RS30510	COG0488	(ABC) transporter
GFH48_RS30520	COG1024	Enoyl-CoA hydratase
GFH48_RS30555	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS30560	COG3387	PFAM Glycoside hydrolase 15-related
GFH48_RS30575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH48_RS30620	COG1063	alcohol dehydrogenase
GFH48_RS30625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH48_RS30640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH48_RS30645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFH48_RS30665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFH48_RS30675	COG0312	modulator of DNA gyrase
GFH48_RS30680	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS30695	COG2186	Transcriptional regulator
GFH48_RS30715	COG0588	phosphoglycerate mutase activity
GFH48_RS30720	COG3830	Belongs to the UPF0237 family
GFH48_RS30720	COG0560	Phosphoserine phosphatase
GFH48_RS30730	COG1131	(ABC) transporter
GFH48_RS30730	COG1716	ATPase activity
GFH48_RS30730	COG0842	Transport permease protein
GFH48_RS30740	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFH48_RS30745	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS30750	COG4585	Histidine kinase
GFH48_RS30755	COG2197	response regulator
GFH48_RS30775	COG1119	ATPase activity
GFH48_RS30795	COG1881	PFAM PEBP family protein
GFH48_RS30805	COG2094	Belongs to the DNA glycosylase MPG family
GFH48_RS30835	COG0647	UMP catabolic process
GFH48_RS30840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH48_RS30845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH48_RS30850	COG1120	ATPase activity
GFH48_RS30870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFH48_RS30875	COG0497	DNA recombination
GFH48_RS30885	COG0297	glycogen (starch) synthase activity
GFH48_RS30895	COG3387	PFAM Glycoside hydrolase 15-related
GFH48_RS30900	COG0504	CTP synthase activity
GFH48_RS30905	COG0494	nUDIX hydrolase
GFH48_RS30915	COG0686	Belongs to the AlaDH PNT family
GFH48_RS30930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFH48_RS30935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFH48_RS30940	COG1187	pseudouridine synthase activity
GFH48_RS30955	COG3541	Predicted nucleotidyltransferase
GFH48_RS30995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFH48_RS31005	COG1160	GTP binding
GFH48_RS31020	COG1652	LysM domain
GFH48_RS31040	COG0671	phosphoesterase, PA-phosphatase related
GFH48_RS31050	COG0477	Major facilitator Superfamily
GFH48_RS31060	COG1799	cell septum assembly
GFH48_RS31105	COG0587	DNA-directed DNA polymerase activity
GFH48_RS31120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFH48_RS31120	COG0662	Cupin 2, conserved barrel domain protein
GFH48_RS31160	COG1309	transcriptional regulator
GFH48_RS31165	COG0477	Major facilitator Superfamily
GFH48_RS31190	COG1725	Transcriptional regulator
GFH48_RS31210	COG0726	polysaccharide deacetylase
GFH48_RS31215	COG1216	Glycosyl transferase, family 2
GFH48_RS31220	COG0463	Glycosyl transferase, family 2
GFH48_RS31235	COG2755	lipolytic protein G-D-S-L family
GFH48_RS31240	COG2815	serine threonine protein kinase
GFH48_RS31240	COG0515	serine threonine protein kinase
GFH48_RS31260	COG1595	DNA-templated transcription, initiation
GFH48_RS31285	COG2188	Transcriptional regulator
GFH48_RS31290	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GFH48_RS31300	COG1309	transcriptional regulator
GFH48_RS31305	COG0243	molybdopterin cofactor binding
GFH48_RS31330	COG0697	spore germination
GFH48_RS31335	COG0640	Transcriptional regulator
GFH48_RS31345	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS31365	COG0789	Transcriptional regulator
GFH48_RS31385	COG3876	Protein conserved in bacteria
GFH48_RS31395	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS31425	COG2149	membrane
GFH48_RS31430	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GFH48_RS31440	COG3573	Dehydrogenase
GFH48_RS31465	COG1063	alcohol dehydrogenase
GFH48_RS31470	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS31480	COG3265	gluconokinase activity
GFH48_RS31485	COG2186	Transcriptional regulator
GFH48_RS31490	COG3012	SEC-C Motif Domain Protein
GFH48_RS31495	COG0308	aminopeptidase N
GFH48_RS31510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH48_RS31545	COG0667	Aldo Keto reductase
GFH48_RS31550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS31560	COG0598	Magnesium transport protein CorA
GFH48_RS31580	COG0215	cysteine-tRNA ligase activity
GFH48_RS31590	COG1404	Belongs to the peptidase S8 family
GFH48_RS31600	COG2186	Transcriptional regulator
GFH48_RS31610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFH48_RS31615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH48_RS31620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH48_RS31625	COG1414	Transcriptional regulator
GFH48_RS31630	COG0646	methionine synthase
GFH48_RS31630	COG1410	methionine synthase
GFH48_RS31635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH48_RS31645	COG4166	transmembrane transport
GFH48_RS31650	COG2197	response regulator
GFH48_RS31660	COG1994	Peptidase M50
GFH48_RS31660	COG0517	IMP dehydrogenase activity
GFH48_RS31685	COG1222	aaa ATPase
GFH48_RS31690	COG4122	O-methyltransferase activity
GFH48_RS31705	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFH48_RS31710	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFH48_RS31715	COG1609	Transcriptional regulator
GFH48_RS31725	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFH48_RS31730	COG0545	Peptidyl-prolyl cis-trans isomerase
GFH48_RS31760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH48_RS31765	COG0805	protein transport
GFH48_RS31830	COG0564	pseudouridine synthase activity
GFH48_RS31845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH48_RS31850	COG4175	Glycine betaine
GFH48_RS31850	COG0517	IMP dehydrogenase activity
GFH48_RS31855	COG4176	ABC-type proline glycine betaine transport system permease component
GFH48_RS31865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFH48_RS31905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GFH48_RS31910	COG2186	Transcriptional regulator
GFH48_RS31915	COG0174	glutamine synthetase
GFH48_RS31920	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS31930	COG0560	Phosphoserine phosphatase
GFH48_RS31930	COG3830	Belongs to the UPF0237 family
GFH48_RS31975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFH48_RS31980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFH48_RS31985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFH48_RS31990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH48_RS31995	COG5002	protein histidine kinase activity
GFH48_RS32000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFH48_RS32005	COG0072	phenylalanine-tRNA ligase activity
GFH48_RS32005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH48_RS32035	COG1649	PFAM Uncharacterised BCR, COG1649
GFH48_RS32045	COG0697	spore germination
GFH48_RS32085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GFH48_RS32130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFH48_RS32135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GFH48_RS32140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFH48_RS32145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH48_RS32150	COG1438	arginine binding
GFH48_RS32185	COG2205	protein histidine kinase activity
GFH48_RS32200	COG0137	argininosuccinate synthase activity
GFH48_RS32205	COG0165	Argininosuccinate lyase
GFH48_RS32220	COG0477	Major facilitator Superfamily
GFH48_RS32225	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS32225	COG0204	Acyl-transferase
GFH48_RS32260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFH48_RS32265	COG2011	ABC-type metal ion transport system permease component
GFH48_RS32270	COG1464	Belongs to the NlpA lipoprotein family
GFH48_RS32285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GFH48_RS32290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFH48_RS32290	COG1648	precorrin-2 dehydrogenase activity
GFH48_RS32350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFH48_RS32360	COG0456	acetyltransferase
GFH48_RS32405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFH48_RS32420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFH48_RS32440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFH48_RS32445	COG1560	Kdo2-lipid A biosynthetic process
GFH48_RS32450	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS32460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GFH48_RS32465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GFH48_RS32470	COG0217	transcriptional regulatory protein
GFH48_RS32475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFH48_RS32480	COG0632	four-way junction helicase activity
GFH48_RS32485	COG2255	four-way junction helicase activity
GFH48_RS32495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH48_RS32500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH48_RS32505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFH48_RS32510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH48_RS32515	COG1196	nuclear chromosome segregation
GFH48_RS32520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFH48_RS32530	COG0124	histidyl-tRNA synthetase
GFH48_RS32535	COG2197	response regulator
GFH48_RS32565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFH48_RS32585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFH48_RS32590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFH48_RS32595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFH48_RS32600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFH48_RS32605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFH48_RS32610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFH48_RS32615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFH48_RS32625	COG0006	proline dipeptidase activity
GFH48_RS32630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFH48_RS32635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFH48_RS32645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFH48_RS32650	COG0540	Belongs to the ATCase OTCase family
GFH48_RS32655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH48_RS32665	COG0505	Belongs to the CarA family
GFH48_RS32670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFH48_RS32675	COG0167	dihydroorotate dehydrogenase activity
GFH48_RS32680	COG0284	orotidine-5'-phosphate decarboxylase activity
GFH48_RS32690	COG0194	GDP metabolic process
GFH48_RS32705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFH48_RS32720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFH48_RS32730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFH48_RS32735	COG2390	Transcriptional regulator
GFH48_RS32755	COG0531	amino acid
GFH48_RS32765	COG2188	Transcriptional regulator
GFH48_RS32785	COG3842	ATPase activity
GFH48_RS32790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH48_RS32795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH48_RS32815	COG2233	PERMEase
GFH48_RS32830	COG2223	nitrite transmembrane transporter activity
GFH48_RS32835	COG1846	Transcriptional regulator
GFH48_RS32835	COG1940	carbohydrate kinase activity
GFH48_RS32845	COG3201	nicotinamide mononucleotide transporter
GFH48_RS32850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH48_RS32850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH48_RS32855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFH48_RS32860	COG0140	phosphoribosyl-ATP diphosphatase activity
GFH48_RS32865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFH48_RS32910	COG1309	transcriptional regulator
GFH48_RS32945	COG0463	Glycosyl transferase, family 2
GFH48_RS32960	COG2270	Major facilitator Superfamily
GFH48_RS33000	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS33005	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS33015	COG1984	allophanate hydrolase subunit 2
GFH48_RS33020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GFH48_RS33025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GFH48_RS33030	COG4336	lyase activity
GFH48_RS33035	COG2814	Major facilitator Superfamily
GFH48_RS33070	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS33080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH48_RS33095	COG1414	Transcriptional regulator
GFH48_RS33100	COG2146	nitrite reductase [NAD(P)H] activity
GFH48_RS33105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFH48_RS33120	COG2018	Roadblock/LC7 domain
GFH48_RS33135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH48_RS33140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH48_RS33145	COG3706	GGDEF domain
GFH48_RS33150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH48_RS33160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GFH48_RS33175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH48_RS33185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFH48_RS33215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFH48_RS33235	COG1716	ATPase activity
GFH48_RS33255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFH48_RS33265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH48_RS33265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH48_RS33270	COG0739	heme binding
GFH48_RS33300	COG0384	phenazine biosynthesis protein PhzF
GFH48_RS33335	COG0697	spore germination
GFH48_RS33395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFH48_RS33405	COG2318	DinB family
GFH48_RS33415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GFH48_RS33425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH48_RS33435	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS33445	COG1968	undecaprenyl-diphosphatase activity
GFH48_RS33455	COG0183	Belongs to the thiolase family
GFH48_RS33465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFH48_RS33490	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GFH48_RS33505	COG0110	maltose O-acetyltransferase activity
GFH48_RS33535	COG1832	CoA-binding protein
GFH48_RS33570	COG1739	Uncharacterized protein family UPF0029
GFH48_RS33575	COG0420	3'-5' exonuclease activity
GFH48_RS33580	COG0419	ATPase involved in DNA repair
GFH48_RS33585	COG1522	sequence-specific DNA binding
GFH48_RS33620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH48_RS33635	COG1595	DNA-templated transcription, initiation
GFH48_RS33640	COG2188	Transcriptional regulator
GFH48_RS33645	COG1940	carbohydrate kinase activity
GFH48_RS33650	COG2197	response regulator
GFH48_RS33655	COG4585	Histidine kinase
GFH48_RS33670	COG3663	DNA glycosylase
GFH48_RS33675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFH48_RS33705	COG0577	efflux transmembrane transporter activity
GFH48_RS33705	COG1136	(ABC) transporter
GFH48_RS33725	COG2226	methyltransferase
GFH48_RS33730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GFH48_RS33735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFH48_RS33740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFH48_RS33765	COG0583	DNA-binding transcription factor activity
GFH48_RS33785	COG0740	serine-type endopeptidase activity
GFH48_RS33795	COG0831	urea catabolic process
GFH48_RS33800	COG0832	Belongs to the urease beta subunit family
GFH48_RS33805	COG0804	urea catabolic process
GFH48_RS33815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GFH48_RS33820	COG0829	nickel cation binding
GFH48_RS33830	COG0204	Acyl-transferase
GFH48_RS33835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH48_RS33840	COG1834	amidinotransferase
GFH48_RS33860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH48_RS33865	COG3275	phosphorelay sensor kinase activity
GFH48_RS33880	COG0205	6-phosphofructokinase activity
GFH48_RS33885	COG3442	glutamine amidotransferase
GFH48_RS33895	COG0242	peptide deformylase activity
GFH48_RS33905	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS33920	COG2124	cytochrome p450
GFH48_RS33925	COG3424	synthase
GFH48_RS33950	COG1793	dna ligase
GFH48_RS33955	COG0492	ferredoxin-NADP+ reductase activity
GFH48_RS33970	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS33975	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS34005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFH48_RS34045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFH48_RS34060	COG0477	Major facilitator Superfamily
GFH48_RS34165	COG1136	(ABC) transporter
GFH48_RS34165	COG0577	efflux transmembrane transporter activity
GFH48_RS34195	COG0583	DNA-binding transcription factor activity
GFH48_RS34215	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS34230	COG0477	Major facilitator Superfamily
GFH48_RS34245	COG0596	Alpha beta hydrolase
GFH48_RS34250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH48_RS34280	COG1733	regulation of RNA biosynthetic process
GFH48_RS34285	COG1063	alcohol dehydrogenase
GFH48_RS34295	COG0300	oxidoreductase activity
GFH48_RS34305	COG3903	Transcriptional regulator
GFH48_RS34305	COG3629	intracellular signal transduction
GFH48_RS34305	COG3903	Transcriptional regulator
GFH48_RS34305	COG3629	intracellular signal transduction
GFH48_RS34335	COG1131	(ABC) transporter
GFH48_RS34340	COG0842	Transport permease protein
GFH48_RS34400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFH48_RS34405	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GFH48_RS34415	COG1215	transferase activity, transferring glycosyl groups
GFH48_RS34425	COG4310	Domain of unknown function (DUF2172)
GFH48_RS34440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFH48_RS34450	COG0438	transferase activity, transferring glycosyl groups
GFH48_RS34495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH48_RS34500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFH48_RS34525	COG1595	DNA-templated transcription, initiation
GFH48_RS34560	COG4221	oxidoreductase activity
GFH48_RS34585	COG2132	Multicopper oxidase
GFH48_RS34635	COG4221	oxidoreductase activity
GFH48_RS34665	COG1302	Protein conserved in bacteria
GFH48_RS34670	COG1595	DNA-templated transcription, initiation
GFH48_RS34760	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH48_RS34775	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS34795	COG1846	Transcriptional regulator
GFH48_RS34795	COG1940	carbohydrate kinase activity
GFH48_RS34800	COG1070	Carbohydrate kinase
GFH48_RS34805	COG2115	Belongs to the xylose isomerase family
GFH48_RS34820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH48_RS34870	COG2018	Roadblock/LC7 domain
GFH48_RS34890	COG2018	Roadblock/LC7 domain
GFH48_RS34900	COG1946	Acyl-CoA thioesterase
GFH48_RS34915	COG0254	rRNA binding
GFH48_RS34925	COG1132	(ABC) transporter
GFH48_RS34950	COG1132	(ABC) transporter
GFH48_RS34970	COG1116	anion transmembrane transporter activity
GFH48_RS34975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH48_RS34980	COG0432	Pfam Uncharacterised protein family UPF0047
GFH48_RS34990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH48_RS35015	COG0456	acetyltransferase
GFH48_RS35050	COG0745	RESPONSE REGULATOR receiver
GFH48_RS35070	COG2208	phosphoserine phosphatase activity
GFH48_RS35070	COG2770	Histidine kinase
GFH48_RS35090	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GFH48_RS35095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFH48_RS35105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH48_RS35130	COG2326	polyphosphate kinase activity
GFH48_RS35135	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GFH48_RS35165	COG0549	Belongs to the carbamate kinase family
GFH48_RS35175	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GFH48_RS35180	COG2706	6-phosphogluconolactonase activity
GFH48_RS35190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFH48_RS35205	COG0640	Transcriptional regulator
GFH48_RS35210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFH48_RS35230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFH48_RS35230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFH48_RS35255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFH48_RS35265	COG1053	succinate dehydrogenase
GFH48_RS35270	COG1764	response to oxidative stress
GFH48_RS35275	COG1595	DNA-templated transcription, initiation
GFH48_RS35295	COG4221	oxidoreductase activity
GFH48_RS35315	COG1902	pentaerythritol trinitrate reductase activity
GFH48_RS35320	COG0640	Transcriptional regulator
GFH48_RS35345	COG1309	transcriptional regulator
GFH48_RS35390	COG0584	glycerophosphoryl diester phosphodiesterase
GFH48_RS35420	COG0204	Acyl-transferase
GFH48_RS35445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFH48_RS35470	COG3345	alpha-galactosidase
GFH48_RS35495	COG1660	Displays ATPase and GTPase activities
GFH48_RS35505	COG0445	tRNA wobble uridine modification
GFH48_RS35520	COG4585	Histidine kinase
GFH48_RS35525	COG2197	response regulator
GFH48_RS35565	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS35570	COG3321	synthase
GFH48_RS35570	COG0604	alcohol dehydrogenase
GFH48_RS35575	COG3320	Male sterility
GFH48_RS35575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH48_RS35585	COG2267	carboxylic ester hydrolase activity
GFH48_RS35595	COG2986	histidine ammonia-lyase
GFH48_RS35610	COG2018	Roadblock/LC7 domain
GFH48_RS35630	COG1174	glycine betaine transport
GFH48_RS35640	COG3537	Alpha-1,2-mannosidase
GFH48_RS35645	COG2813	Specifically methylates the guanine in position
GFH48_RS35660	COG1940	carbohydrate kinase activity
GFH48_RS35675	COG1136	(ABC) transporter
GFH48_RS35680	COG0577	efflux transmembrane transporter activity
GFH48_RS35705	COG1349	DNA-binding transcription factor activity
GFH48_RS35725	COG3217	Mosc domain protein beta barrel domain protein
GFH48_RS35725	COG0633	Ferredoxin
GFH48_RS35740	COG1215	transferase activity, transferring glycosyl groups
GFH48_RS35745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFH48_RS35770	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS35825	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS35855	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS35865	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH48_RS35875	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS35925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFH48_RS35930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFH48_RS35955	COG1834	amidinotransferase
GFH48_RS36025	COG4948	Mandelate Racemase Muconate Lactonizing
GFH48_RS36030	COG0477	Major facilitator Superfamily
GFH48_RS36040	COG1716	ATPase activity
GFH48_RS36055	COG1408	metallophosphoesterase
GFH48_RS36065	COG0515	serine threonine protein kinase
GFH48_RS36075	COG1132	(ABC) transporter
GFH48_RS36080	COG1132	(ABC) transporter
GFH48_RS36100	COG2318	DinB family
GFH48_RS36130	COG4335	DNA alkylation repair
GFH48_RS36160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFH48_RS36240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH48_RS36245	COG1993	acr, cog1993
GFH48_RS36250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH48_RS36255	COG1968	undecaprenyl-diphosphatase activity
GFH48_RS36260	COG2066	Belongs to the glutaminase family
GFH48_RS36280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GFH48_RS36290	COG3795	YCII-related domain
GFH48_RS36300	COG4941	Belongs to the sigma-70 factor family
GFH48_RS36305	COG0366	Alpha amylase catalytic
GFH48_RS36320	COG0604	alcohol dehydrogenase
GFH48_RS36325	COG2205	protein histidine kinase activity
GFH48_RS36330	COG0745	RESPONSE REGULATOR receiver
GFH48_RS36335	COG2409	Drug exporters of the RND superfamily
GFH48_RS36345	COG2188	Transcriptional regulator
GFH48_RS36350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFH48_RS36360	COG3458	cephalosporin-C deacetylase activity
GFH48_RS36375	COG0604	alcohol dehydrogenase
GFH48_RS36375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFH48_RS36375	COG3321	synthase
GFH48_RS36375	COG4221	oxidoreductase activity
GFH48_RS36395	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH48_RS36400	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH48_RS36400	COG1902	pentaerythritol trinitrate reductase activity
GFH48_RS36430	COG1461	Dihydroxyacetone kinase
GFH48_RS36435	COG2376	Dihydroxyacetone kinase
GFH48_RS36445	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS36450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH48_RS36485	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS36495	COG0515	serine threonine protein kinase
GFH48_RS36505	COG2070	2-Nitropropane dioxygenase
GFH48_RS36520	COG0318	PFAM AMP-dependent synthetase and ligase
GFH48_RS36560	COG1672	PFAM Archaeal ATPase
GFH48_RS36560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH48_RS36610	COG3511	phospholipase C
GFH48_RS36615	COG0673	inositol 2-dehydrogenase activity
GFH48_RS36625	COG2235	arginine
GFH48_RS36630	COG0069	glutamate synthase activity
GFH48_RS36635	COG0367	asparagine synthase
GFH48_RS36660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH48_RS36685	COG1940	carbohydrate kinase activity
GFH48_RS36690	COG0531	amino acid
GFH48_RS36765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFH48_RS36770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFH48_RS36785	COG1595	DNA-templated transcription, initiation
GFH48_RS36810	COG3547	Transposase (IS116 IS110 IS902 family)
GFH48_RS36815	COG0702	epimerase
GFH48_RS36820	COG1846	Transcriptional regulator
GFH48_RS36825	COG2409	Drug exporters of the RND superfamily
GFH48_RS36850	COG0431	NADPH-dependent FMN reductase
GFH48_RS36870	COG3795	YCII-related domain
GFH48_RS36875	COG4941	Belongs to the sigma-70 factor family
GFH48_RS36885	COG1309	transcriptional regulator
GFH48_RS36895	COG1012	belongs to the aldehyde dehydrogenase family
GFH48_RS36905	COG0667	Aldo Keto reductase
GFH48_RS36910	COG0412	Dienelactone hydrolase
GFH48_RS36920	COG0671	phosphoesterase, PA-phosphatase related
GFH48_RS36925	COG0346	lactoylglutathione lyase activity
GFH48_RS36930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH48_RS36945	COG0583	DNA-binding transcription factor activity
GFH48_RS36950	COG0667	Aldo Keto reductase
GFH48_RS37005	COG4251	negative regulation of phosphorylation
GFH48_RS37010	COG0784	Response regulator, receiver
GFH48_RS37030	COG0740	serine-type endopeptidase activity
GFH48_RS37035	COG0740	serine-type endopeptidase activity
GFH48_RS37040	COG0596	Alpha beta hydrolase
GFH48_RS37070	COG0583	DNA-binding transcription factor activity
GFH48_RS37075	COG1028	Short-chain dehydrogenase reductase Sdr
GFH48_RS37090	COG0328	RNA-DNA hybrid ribonuclease activity
GFH48_RS37095	COG2304	oxidoreductase activity
GFH48_RS37135	COG0431	NADPH-dependent FMN reductase
GFH48_RS37145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFH48_RS37165	COG1940	carbohydrate kinase activity
GFH48_RS37165	COG1846	Transcriptional regulator
GFH48_RS37175	COG1175	transmembrane transport
GFH48_RS37180	COG0395	ABC-type sugar transport system, permease component
GFH48_RS37185	COG3345	alpha-galactosidase
GFH48_RS37250	COG0477	Major facilitator Superfamily
GFH48_RS37260	COG1846	Transcriptional regulator
GFH48_RS37270	COG0842	Transport permease protein
GFH48_RS37280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFH48_RS37285	COG3281	Trehalose synthase
GFH48_RS37290	COG0366	Alpha amylase catalytic
GFH48_RS37295	COG0366	Alpha amylase catalytic
GFH48_RS37315	COG0277	FAD linked oxidase domain protein
GFH48_RS37360	COG1309	transcriptional regulator
GFH48_RS37385	COG0076	glutamate decarboxylase activity
GFH48_RS37405	COG2814	Major facilitator Superfamily
GFH48_RS37410	COG0583	DNA-binding transcription factor activity
GFH48_RS37415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFH48_RS37425	COG0667	Aldo Keto reductase
GFH48_RS37430	COG1017	nitric oxide dioxygenase activity
GFH48_RS37430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFH48_RS37435	COG0596	Alpha beta hydrolase
GFH48_RS37445	COG3864	Putative metallopeptidase domain
GFH48_RS37450	COG0714	Associated with various cellular activities
GFH48_RS37460	COG0137	argininosuccinate synthase activity
GFH48_RS37490	COG1278	Cold shock
GFH48_RS37515	COG1846	Transcriptional regulator
GFH48_RS37520	COG0477	Major facilitator Superfamily
GFH48_RS37530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFH48_RS37560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFH48_RS37565	COG1316	TRANSCRIPTIONal
GFH48_RS37585	COG3250	beta-galactosidase activity
GFH48_RS37750	COG0745	RESPONSE REGULATOR receiver
GFH48_RS37755	COG5002	protein histidine kinase activity
GFH48_RS37865	COG0366	Alpha amylase catalytic
GFH48_RS37885	COG2197	response regulator
GFH48_RS37890	COG4585	Histidine kinase
GFH48_RS37895	COG2409	Drug exporters of the RND superfamily
GFH48_RS37955	COG1960	acyl-CoA dehydrogenase activity
GFH48_RS38065	COG1595	DNA-templated transcription, initiation
GFH48_RS38070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GFH48_RS38125	COG0640	Transcriptional regulator
GFH48_RS38175	COG0640	Transcriptional regulator
GFH48_RS38185	COG2072	flavoprotein involved in K transport
GFH48_RS38190	COG0798	PFAM Bile acid sodium symporter
GFH48_RS38200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH48_RS38280	COG2826	transposase and inactivated derivatives, IS30 family
GFH48_RS38340	COG2124	cytochrome p450
GFH48_RS38360	COG2867	negative regulation of translational initiation
GFH48_RS38370	COG0736	holo-[acyl-carrier-protein] synthase activity
GFH48_RS38390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta