locus-tag	class	description
K7395_RS00130	COG0702	epimerase
K7395_RS00160	COG2814	Major facilitator Superfamily
K7395_RS00180	COG0515	serine threonine protein kinase
K7395_RS00235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7395_RS00260	COG1070	Carbohydrate kinase
K7395_RS00285	COG4213	ABC transporter substrate-binding protein
K7395_RS00295	COG4214	carbohydrate transport
K7395_RS00310	COG1595	DNA-templated transcription, initiation
K7395_RS00325	COG2226	methyltransferase
K7395_RS00350	COG0586	Pfam SNARE associated Golgi protein
K7395_RS00390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K7395_RS00405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K7395_RS00410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS00425	COG0745	RESPONSE REGULATOR receiver
K7395_RS00430	COG2205	protein histidine kinase activity
K7395_RS00455	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K7395_RS00460	COG0714	Associated with various cellular activities
K7395_RS00470	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS00475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7395_RS00485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS00490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7395_RS00495	COG0395	ABC-type sugar transport system, permease component
K7395_RS00510	COG1609	Transcriptional regulator
K7395_RS00525	COG2318	DinB family
K7395_RS00560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7395_RS00585	COG0009	L-threonylcarbamoyladenylate synthase
K7395_RS00605	COG0488	(ABC) transporter
K7395_RS00660	COG2340	Cysteine-rich secretory protein family
K7395_RS00675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7395_RS00680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7395_RS00700	COG1024	Enoyl-CoA hydratase
K7395_RS00730	COG2018	Roadblock/LC7 domain
K7395_RS00745	COG0640	Transcriptional regulator
K7395_RS00750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7395_RS00755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7395_RS00785	COG3239	Fatty acid desaturase
K7395_RS00790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7395_RS00810	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS00825	COG1472	Belongs to the glycosyl hydrolase 3 family
K7395_RS00835	COG1175	transmembrane transport
K7395_RS00845	COG1609	Transcriptional regulator
K7395_RS00885	COG2175	clavaminate synthase activity
K7395_RS00905	COG1960	acyl-CoA dehydrogenase activity
K7395_RS00910	COG0789	Transcriptional regulator
K7395_RS00935	COG1175	transmembrane transport
K7395_RS00945	COG1063	alcohol dehydrogenase
K7395_RS00965	COG4044	May play a role in the intracellular transport of hydrophobic ligands
K7395_RS00975	COG2375	cellular response to nickel ion
K7395_RS00990	COG0693	protein deglycase activity
K7395_RS00995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K7395_RS01005	COG1278	Cold shock
K7395_RS01055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K7395_RS01095	COG1796	DNA polymerase
K7395_RS01095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K7395_RS01175	COG0444	Belongs to the ABC transporter superfamily
K7395_RS01180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS01185	COG0601	transmembrane transport
K7395_RS01200	COG1960	acyl-CoA dehydrogenase activity
K7395_RS01205	COG1960	acyl-CoA dehydrogenase activity
K7395_RS01225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7395_RS01235	COG0656	L-ascorbic acid biosynthetic process
K7395_RS01275	COG0297	glycogen (starch) synthase activity
K7395_RS01275	COG0438	transferase activity, transferring glycosyl groups
K7395_RS01295	COG0726	polysaccharide deacetylase
K7395_RS01300	COG0438	transferase activity, transferring glycosyl groups
K7395_RS01320	COG2304	oxidoreductase activity
K7395_RS01345	COG1132	(ABC) transporter
K7395_RS01380	COG1120	ATPase activity
K7395_RS01385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS01390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS01405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7395_RS01410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K7395_RS01415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K7395_RS01420	COG0254	rRNA binding
K7395_RS01430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K7395_RS01435	COG0477	Major facilitator Superfamily
K7395_RS01445	COG1120	ATPase activity
K7395_RS01465	COG3250	beta-galactosidase activity
K7395_RS01470	COG1070	Carbohydrate kinase
K7395_RS01475	COG3347	Dehydrogenase
K7395_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS01485	COG1129	ABC transporter
K7395_RS01490	COG1172	Belongs to the binding-protein-dependent transport system permease family
K7395_RS01505	COG1609	Transcriptional regulator
K7395_RS01535	COG1233	COG1233 Phytoene dehydrogenase and related
K7395_RS01560	COG0657	acetylesterase activity
K7395_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS01625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K7395_RS01640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7395_RS01650	COG1228	amidohydrolase
K7395_RS01660	COG1834	amidinotransferase
K7395_RS01665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7395_RS01680	COG2045	Belongs to the ComB family
K7395_RS01690	COG1357	PFAM Pentapeptide repeats (8 copies)
K7395_RS01715	COG0714	Associated with various cellular activities
K7395_RS01745	COG2226	methyltransferase
K7395_RS01750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7395_RS01755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7395_RS01765	COG1609	Transcriptional regulator
K7395_RS01785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K7395_RS01790	COG0121	glutamine amidotransferase
K7395_RS01795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K7395_RS01810	COG2182	Extracellular solute-binding protein
K7395_RS01815	COG3360	Dodecin
K7395_RS01840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K7395_RS01845	COG1053	succinate dehydrogenase
K7395_RS01930	COG3275	phosphorelay sensor kinase activity
K7395_RS01935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7395_RS01965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7395_RS02010	COG1191	sigma factor activity
K7395_RS02015	COG4566	intracellular signal transduction
K7395_RS02020	COG4251	negative regulation of phosphorylation
K7395_RS02025	COG0784	Response regulator, receiver
K7395_RS02045	COG2208	phosphoserine phosphatase activity
K7395_RS02070	COG1652	LysM domain
K7395_RS02075	COG1309	transcriptional regulator
K7395_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS02105	COG1175	transmembrane transport
K7395_RS02110	COG0395	ABC-type sugar transport system, permease component
K7395_RS02130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K7395_RS02155	COG2801	Transposase and inactivated derivatives
K7395_RS02155	COG3415	Transposase
K7395_RS02165	COG1595	DNA-templated transcription, initiation
K7395_RS02175	COG1119	ATPase activity
K7395_RS02185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K7395_RS02210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K7395_RS02215	COG2837	iron assimilation
K7395_RS02225	COG0019	diaminopimelate decarboxylase activity
K7395_RS02240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K7395_RS02260	COG0640	Transcriptional regulator
K7395_RS02270	COG2072	flavoprotein involved in K transport
K7395_RS02275	COG2072	flavoprotein involved in K transport
K7395_RS02280	COG0798	PFAM Bile acid sodium symporter
K7395_RS02290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7395_RS02295	COG0492	ferredoxin-NADP+ reductase activity
K7395_RS02300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7395_RS02310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7395_RS02315	COG0745	RESPONSE REGULATOR receiver
K7395_RS02320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K7395_RS02325	COG0581	inorganic phosphate transmembrane transporter activity
K7395_RS02330	COG0573	inorganic phosphate transmembrane transporter activity
K7395_RS02335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7395_RS02345	COG0659	secondary active sulfate transmembrane transporter activity
K7395_RS02350	COG0789	Transcriptional regulator
K7395_RS02360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K7395_RS02380	COG1309	transcriptional regulator
K7395_RS02385	COG3973	AAA domain
K7395_RS02390	COG2271	Major facilitator Superfamily
K7395_RS02395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7395_RS02400	COG0659	secondary active sulfate transmembrane transporter activity
K7395_RS02445	COG3594	Acyltransferase
K7395_RS02450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K7395_RS02475	COG0640	Transcriptional regulator
K7395_RS02505	COG2130	NADP-dependent
K7395_RS02510	COG1233	COG1233 Phytoene dehydrogenase and related
K7395_RS02555	COG1846	Transcriptional regulator
K7395_RS02560	COG2409	Drug exporters of the RND superfamily
K7395_RS02575	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7395_RS02575	COG1902	pentaerythritol trinitrate reductase activity
K7395_RS02610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K7395_RS02625	COG4412	M6 family metalloprotease domain protein
K7395_RS02625	COG1404	Belongs to the peptidase S8 family
K7395_RS02685	COG1556	Lactate utilization protein
K7395_RS02690	COG1139	Iron-sulfur cluster binding protein
K7395_RS02695	COG0247	lactate metabolic process
K7395_RS02700	COG2186	Transcriptional regulator
K7395_RS02710	COG3851	Histidine kinase
K7395_RS02715	COG2197	response regulator
K7395_RS02725	COG3511	phospholipase C
K7395_RS02730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7395_RS02815	COG3959	Transketolase, thiamine diphosphate binding domain
K7395_RS02820	COG3958	Transketolase
K7395_RS02845	COG1162	GTPase activity
K7395_RS02855	COG1116	anion transmembrane transporter activity
K7395_RS02865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K7395_RS02870	COG1609	Transcriptional regulator
K7395_RS02925	COG0789	Transcriptional regulator
K7395_RS02935	COG3467	pyridoxamine 5'-phosphate
K7395_RS02975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7395_RS02985	COG2755	lipolytic protein G-D-S-L family
K7395_RS02990	COG0739	heme binding
K7395_RS03025	COG1657	PFAM Prenyltransferase squalene oxidase
K7395_RS03035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K7395_RS03045	COG1562	ergosterol biosynthetic process
K7395_RS03050	COG1134	teichoic acid transport
K7395_RS03050	COG1388	LysM domain
K7395_RS03070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K7395_RS03095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K7395_RS03110	COG1024	Enoyl-CoA hydratase
K7395_RS03120	COG4977	sequence-specific DNA binding
K7395_RS03135	COG0488	(ABC) transporter
K7395_RS03155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7395_RS03180	COG0789	Transcriptional regulator
K7395_RS03185	COG1024	Enoyl-CoA hydratase
K7395_RS03185	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7395_RS03190	COG0183	Belongs to the thiolase family
K7395_RS03195	COG1960	acyl-CoA dehydrogenase activity
K7395_RS03200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K7395_RS03205	COG3268	Saccharopine dehydrogenase
K7395_RS03220	COG1515	deoxyribonuclease V activity
K7395_RS03250	COG0488	(ABC) transporter
K7395_RS03260	COG2267	carboxylic ester hydrolase activity
K7395_RS03265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7395_RS03315	COG1793	dna ligase
K7395_RS03350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K7395_RS03375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K7395_RS03420	COG1960	acyl-CoA dehydrogenase activity
K7395_RS03445	COG3012	SEC-C Motif Domain Protein
K7395_RS03475	COG1486	melibiose metabolic process
K7395_RS03480	COG2124	cytochrome p450
K7395_RS03505	COG1846	Transcriptional regulator
K7395_RS03510	COG1289	transmembrane transporter activity
K7395_RS03530	COG1940	carbohydrate kinase activity
K7395_RS03540	COG1070	Carbohydrate kinase
K7395_RS03550	COG0488	(ABC) transporter
K7395_RS03575	COG0569	domain protein
K7395_RS03575	COG2985	domain, Protein
K7395_RS03590	COG2124	cytochrome p450
K7395_RS03600	COG4176	ABC-type proline glycine betaine transport system permease component
K7395_RS03605	COG4175	Glycine betaine
K7395_RS03605	COG0517	IMP dehydrogenase activity
K7395_RS03615	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS03700	COG3568	Endonuclease Exonuclease Phosphatase
K7395_RS03710	COG3903	Transcriptional regulator
K7395_RS03710	COG3629	intracellular signal transduction
K7395_RS03720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS03730	COG0714	Associated with various cellular activities
K7395_RS03740	COG1376	ErfK ybiS ycfS ynhG family protein
K7395_RS03750	COG0745	RESPONSE REGULATOR receiver
K7395_RS03755	COG2205	protein histidine kinase activity
K7395_RS03765	COG1869	D-ribose catabolic process
K7395_RS03770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS03780	COG1129	ABC transporter
K7395_RS03835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K7395_RS03855	COG0673	inositol 2-dehydrogenase activity
K7395_RS03860	COG1879	ABC-type sugar transport system periplasmic component
K7395_RS03865	COG1172	Belongs to the binding-protein-dependent transport system permease family
K7395_RS03870	COG1129	ABC transporter
K7395_RS03880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7395_RS03885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K7395_RS03910	COG0656	L-ascorbic acid biosynthetic process
K7395_RS03920	COG0357	Ribosomal RNA small subunit methyltransferase G
K7395_RS03930	COG0702	epimerase
K7395_RS03940	COG2154	pterin-4-alpha-carbinolamine dehydratase
K7395_RS03950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7395_RS03950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7395_RS03965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K7395_RS04035	COG1619	proteins homologs of microcin C7 resistance protein MccF
K7395_RS04045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7395_RS04050	COG2362	D-Aminopeptidase
K7395_RS04070	COG0667	Aldo Keto reductase
K7395_RS04075	COG0583	DNA-binding transcription factor activity
K7395_RS04100	COG0596	Alpha beta hydrolase
K7395_RS04115	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7395_RS04130	COG0604	alcohol dehydrogenase
K7395_RS04135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7395_RS04135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7395_RS04140	COG2301	Belongs to the HpcH HpaI aldolase family
K7395_RS04150	COG1960	acyl-CoA dehydrogenase activity
K7395_RS04155	COG0688	phosphatidylethanolamine metabolic process
K7395_RS04170	COG0515	serine threonine protein kinase
K7395_RS04170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7395_RS04180	COG0559	Belongs to the binding-protein-dependent transport system permease family
K7395_RS04185	COG0559	Belongs to the binding-protein-dependent transport system permease family
K7395_RS04210	COG1929	Belongs to the glycerate kinase type-1 family
K7395_RS04235	COG3547	Transposase (IS116 IS110 IS902 family)
K7395_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS04260	COG0583	DNA-binding transcription factor activity
K7395_RS04295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7395_RS04315	COG0483	inositol monophosphate 1-phosphatase activity
K7395_RS04330	COG2233	PERMEase
K7395_RS04360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K7395_RS04380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K7395_RS04385	COG0477	Major facilitator Superfamily
K7395_RS04430	COG0640	Transcriptional regulator
K7395_RS04440	COG0095	Lipoate-protein ligase
K7395_RS04460	COG2838	Isocitrate dehydrogenase
K7395_RS04465	COG2205	protein histidine kinase activity
K7395_RS04475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K7395_RS04480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7395_RS04500	COG1953	Uracil, thiamine, allantoin
K7395_RS04510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7395_RS04515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7395_RS04550	COG0405	Gamma-glutamyltransferase
K7395_RS04570	COG0765	amino acid transport
K7395_RS04575	COG0765	amino acid transport
K7395_RS04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS04585	COG1126	abc transporter atp-binding protein
K7395_RS04595	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS04610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K7395_RS04615	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7395_RS04625	COG1940	carbohydrate kinase activity
K7395_RS04630	COG1129	ABC transporter
K7395_RS04640	COG1879	ABC-type sugar transport system periplasmic component
K7395_RS04645	COG2188	Transcriptional regulator
K7395_RS04650	COG0673	inositol 2-dehydrogenase activity
K7395_RS04660	COG2197	response regulator
K7395_RS04685	COG0656	L-ascorbic acid biosynthetic process
K7395_RS04690	COG4266	Belongs to the allantoicase family
K7395_RS04695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7395_RS04700	COG1414	Transcriptional regulator
K7395_RS04720	COG2197	response regulator
K7395_RS04735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K7395_RS04740	COG0242	peptide deformylase activity
K7395_RS04775	COG0596	Alpha beta hydrolase
K7395_RS04780	COG2233	PERMEase
K7395_RS04790	COG2233	PERMEase
K7395_RS04800	COG2351	hydroxyisourate hydrolase activity
K7395_RS04820	COG2706	6-phosphogluconolactonase activity
K7395_RS04825	COG2188	Transcriptional regulator
K7395_RS04830	COG1653	transport
K7395_RS04835	COG1175	transmembrane transport
K7395_RS04840	COG0395	ABC-type sugar transport system, permease component
K7395_RS04845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K7395_RS04850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K7395_RS04855	COG3622	Belongs to the hyi family
K7395_RS04860	COG2084	Dehydrogenase
K7395_RS04865	COG0753	catalase activity
K7395_RS04880	COG3960	tartronate-semialdehyde synthase activity
K7395_RS04905	COG1136	(ABC) transporter
K7395_RS04905	COG0577	efflux transmembrane transporter activity
K7395_RS04910	COG4585	Histidine kinase
K7395_RS04915	COG2197	response regulator
K7395_RS04920	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS04925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7395_RS04930	COG2197	response regulator
K7395_RS04945	COG0435	Glutathione S-transferase
K7395_RS04965	COG0667	Aldo Keto reductase
K7395_RS04985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7395_RS05030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K7395_RS05030	COG3608	succinylglutamate desuccinylase aspartoacylase
K7395_RS05035	COG2252	PERMEase
K7395_RS05040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K7395_RS05065	COG1802	Transcriptional regulator
K7395_RS05095	COG0028	Belongs to the TPP enzyme family
K7395_RS05105	COG1404	Belongs to the peptidase S8 family
K7395_RS05125	COG1162	GTPase activity
K7395_RS05175	COG0183	Belongs to the thiolase family
K7395_RS05180	COG0583	DNA-binding transcription factor activity
K7395_RS05185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K7395_RS05190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K7395_RS05195	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7395_RS05215	COG1960	acyl-CoA dehydrogenase activity
K7395_RS05240	COG0175	sulfate reduction
K7395_RS05245	COG0529	Catalyzes the synthesis of activated sulfate
K7395_RS05265	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K7395_RS05270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K7395_RS05285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K7395_RS05310	COG1132	(ABC) transporter
K7395_RS05345	COG1175	transmembrane transport
K7395_RS05385	COG0583	DNA-binding transcription factor activity
K7395_RS05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7395_RS05415	COG2723	6-phospho-beta-galactosidase activity
K7395_RS05430	COG1072	(Pantothenic acid kinase))
K7395_RS05435	COG0346	lactoylglutathione lyase activity
K7395_RS05445	COG0477	Major facilitator Superfamily
K7395_RS05460	COG0583	DNA-binding transcription factor activity
K7395_RS05465	COG0156	8-amino-7-oxononanoate synthase activity
K7395_RS05470	COG1063	alcohol dehydrogenase
K7395_RS05480	COG0515	serine threonine protein kinase
K7395_RS05480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7395_RS05490	COG2267	carboxylic ester hydrolase activity
K7395_RS05535	COG0513	Belongs to the DEAD box helicase family
K7395_RS05555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7395_RS05560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7395_RS05620	COG3220	belongs to the UPF0276 family
K7395_RS05635	COG3253	May function as heme-dependent peroxidase
K7395_RS05640	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K7395_RS05650	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7395_RS05655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K7395_RS05680	COG0183	Belongs to the thiolase family
K7395_RS05685	COG1024	Enoyl-CoA hydratase
K7395_RS05685	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7395_RS05695	COG0438	transferase activity, transferring glycosyl groups
K7395_RS05705	COG0438	transferase activity, transferring glycosyl groups
K7395_RS05720	COG1316	TRANSCRIPTIONal
K7395_RS05730	COG0531	amino acid
K7395_RS05735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K7395_RS05740	COG4214	carbohydrate transport
K7395_RS05750	COG4213	ABC transporter substrate-binding protein
K7395_RS05755	COG1940	carbohydrate kinase activity
K7395_RS05760	COG0395	ABC-type sugar transport system, permease component
K7395_RS05765	COG1175	transmembrane transport
K7395_RS05770	COG1653	transport
K7395_RS05780	COG0588	phosphoglycerate mutase activity
K7395_RS05790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K7395_RS05805	COG1742	UPF0060 membrane protein
K7395_RS05810	COG2267	carboxylic ester hydrolase activity
K7395_RS05830	COG3548	integral membrane protein
K7395_RS05835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7395_RS05910	COG0571	ribonuclease III activity
K7395_RS05970	COG0667	Aldo Keto reductase
K7395_RS05995	COG2267	carboxylic ester hydrolase activity
K7395_RS06000	COG0673	inositol 2-dehydrogenase activity
K7395_RS06015	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS06030	COG2319	Wd-40 repeat
K7395_RS06040	COG2319	Wd-40 repeat
K7395_RS06050	COG1960	acyl-CoA dehydrogenase activity
K7395_RS06070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K7395_RS06085	COG1228	amidohydrolase
K7395_RS06100	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS06125	COG2197	response regulator
K7395_RS06130	COG1120	ATPase activity
K7395_RS06135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS06150	COG1132	(ABC) transporter
K7395_RS06180	COG1129	ABC transporter
K7395_RS06190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7395_RS06195	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS06215	COG2172	sigma factor antagonist activity
K7395_RS06215	COG2208	phosphoserine phosphatase activity
K7395_RS06215	COG1366	Belongs to the anti-sigma-factor antagonist family
K7395_RS06230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7395_RS06235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7395_RS06240	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K7395_RS06275	COG0489	protein tyrosine kinase activity
K7395_RS06280	COG0297	glycogen (starch) synthase activity
K7395_RS06295	COG1320	monovalent cation:proton antiporter activity
K7395_RS06310	COG0651	ATP synthesis coupled electron transport
K7395_RS06315	COG1006	Multisubunit Na H antiporter MnhC subunit
K7395_RS06320	COG2111	Na H antiporter
K7395_RS06320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7395_RS06390	COG1024	Enoyl-CoA hydratase
K7395_RS06400	COG0531	amino acid
K7395_RS06405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K7395_RS06415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K7395_RS06425	COG2040	homocysteine
K7395_RS06445	COG1799	cell septum assembly
K7395_RS06450	COG1349	DNA-binding transcription factor activity
K7395_RS06455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7395_RS06460	COG0586	Pfam SNARE associated Golgi protein
K7395_RS06475	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS06480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS06510	COG3046	protein related to deoxyribodipyrimidine photolyase
K7395_RS06515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7395_RS06520	COG1280	lysine exporter protein (LysE YggA)
K7395_RS06530	COG3291	Pkd domain containing protein
K7395_RS06545	COG0601	transmembrane transport
K7395_RS06550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS06560	COG0006	proline dipeptidase activity
K7395_RS06565	COG1802	Transcriptional regulator
K7395_RS06570	COG2423	ornithine cyclodeaminase activity
K7395_RS06580	COG3938	Belongs to the proline racemase family
K7395_RS06590	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7395_RS06610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7395_RS06610	COG1199	ATP-dependent helicase activity
K7395_RS06620	COG2843	Capsule synthesis protein
K7395_RS06625	COG5002	protein histidine kinase activity
K7395_RS06625	COG3850	Histidine kinase
K7395_RS06650	COG4152	abc transporter atp-binding protein
K7395_RS06680	COG2124	cytochrome p450
K7395_RS06740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K7395_RS06745	COG0531	amino acid
K7395_RS06750	COG0569	domain protein
K7395_RS06780	COG4591	ABC-type transport system involved in lipoprotein release permease component
K7395_RS06780	COG1136	(ABC) transporter
K7395_RS06790	COG0756	dUTP diphosphatase activity
K7395_RS06815	COG2205	protein histidine kinase activity
K7395_RS06820	COG0745	RESPONSE REGULATOR receiver
K7395_RS06835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K7395_RS06870	COG1278	Cold shock
K7395_RS06875	COG0577	efflux transmembrane transporter activity
K7395_RS06875	COG1136	(ABC) transporter
K7395_RS06925	COG1088	dTDP-glucose 4,6-dehydratase activity
K7395_RS06940	COG2267	carboxylic ester hydrolase activity
K7395_RS06945	COG1509	lysine 2,3-aminomutase activity
K7395_RS06960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS06970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS07030	COG1309	transcriptional regulator
K7395_RS07035	COG0604	alcohol dehydrogenase
K7395_RS07035	COG3321	synthase
K7395_RS07060	COG0604	alcohol dehydrogenase
K7395_RS07065	COG0604	alcohol dehydrogenase
K7395_RS07065	COG3321	synthase
K7395_RS07090	COG1435	thymidine kinase activity
K7395_RS07105	COG1042	CoA-binding domain protein
K7395_RS07105	COG0045	succinate-CoA ligase (ADP-forming) activity
K7395_RS07105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7395_RS07110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7395_RS07115	COG1802	Transcriptional regulator
K7395_RS07130	COG0612	Peptidase, M16
K7395_RS07135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7395_RS07145	COG0372	Belongs to the citrate synthase family
K7395_RS07150	COG0372	Belongs to the citrate synthase family
K7395_RS07160	COG3290	protein histidine kinase activity
K7395_RS07165	COG4565	transcriptional regulatory protein
K7395_RS07170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7395_RS07195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7395_RS07200	COG2186	Transcriptional regulator
K7395_RS07235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K7395_RS07270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7395_RS07275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K7395_RS07280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K7395_RS07320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K7395_RS07330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7395_RS07335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K7395_RS07345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K7395_RS07360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7395_RS07370	COG2205	protein histidine kinase activity
K7395_RS07375	COG0745	RESPONSE REGULATOR receiver
K7395_RS07380	COG1126	abc transporter atp-binding protein
K7395_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS07390	COG0765	amino acid transport
K7395_RS07395	COG0765	amino acid transport
K7395_RS07410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7395_RS07425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K7395_RS07470	COG1201	RNA secondary structure unwinding
K7395_RS07475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7395_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS07495	COG0783	Belongs to the Dps family
K7395_RS07500	COG1396	sequence-specific DNA binding
K7395_RS07505	COG1546	Belongs to the CinA family
K7395_RS07505	COG1058	Belongs to the CinA family
K7395_RS07515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7395_RS07525	COG1674	ftsk spoiiie
K7395_RS07535	COG2205	protein histidine kinase activity
K7395_RS07535	COG3437	response regulator, receiver
K7395_RS07535	COG3850	Histidine kinase
K7395_RS07535	COG4999	Histidine kinase
K7395_RS07540	COG2208	phosphoserine phosphatase activity
K7395_RS07540	COG2770	Histidine kinase
K7395_RS07565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K7395_RS07570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7395_RS07575	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K7395_RS07595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K7395_RS07600	COG0612	Peptidase, M16
K7395_RS07605	COG1185	polyribonucleotide nucleotidyltransferase activity
K7395_RS07610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K7395_RS07620	COG1674	ftsk spoiiie
K7395_RS07625	COG4842	Belongs to the WXG100 family
K7395_RS07635	COG1404	Belongs to the peptidase S8 family
K7395_RS07650	COG1404	Belongs to the peptidase S8 family
K7395_RS07655	COG3266	domain, Protein
K7395_RS07675	COG0455	bacterial-type flagellum organization
K7395_RS07680	COG0747	negative chemotaxis
K7395_RS07685	COG0601	transmembrane transport
K7395_RS07690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS07735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K7395_RS07740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K7395_RS07750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K7395_RS07765	COG0779	Required for maturation of 30S ribosomal subunits
K7395_RS07785	COG0442	prolyl-tRNA aminoacylation
K7395_RS07800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K7395_RS07805	COG0750	zinc metalloprotease
K7395_RS07810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K7395_RS07815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K7395_RS07825	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS07830	COG2508	Transcriptional regulator
K7395_RS07860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7395_RS07865	COG1177	transmembrane transport
K7395_RS07870	COG1176	ABC-type spermidine putrescine transport system, permease component I
K7395_RS07875	COG3842	ATPase activity
K7395_RS07880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K7395_RS07900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K7395_RS07925	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS07935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7395_RS07940	COG4181	ATPase activity
K7395_RS07965	COG4585	Histidine kinase
K7395_RS07970	COG2197	response regulator
K7395_RS07975	COG3842	ATPase activity
K7395_RS07990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K7395_RS07995	COG0575	Belongs to the CDS family
K7395_RS08000	COG0233	cytoplasmic translational termination
K7395_RS08005	COG0528	UMP kinase activity
K7395_RS08010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K7395_RS08015	COG0052	Belongs to the universal ribosomal protein uS2 family
K7395_RS08030	COG1191	sigma factor activity
K7395_RS08045	COG0792	nuclease activity
K7395_RS08065	COG0681	Belongs to the peptidase S26 family
K7395_RS08070	COG0681	Belongs to the peptidase S26 family
K7395_RS08080	COG0335	large ribosomal subunit rRNA binding
K7395_RS08085	COG0336	Belongs to the RNA methyltransferase TrmD family
K7395_RS08090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K7395_RS08095	COG1837	Belongs to the UPF0109 family
K7395_RS08100	COG0228	four-way junction DNA binding
K7395_RS08120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K7395_RS08155	COG0477	Major facilitator Superfamily
K7395_RS08160	COG1196	nuclear chromosome segregation
K7395_RS08175	COG1254	Belongs to the acylphosphatase family
K7395_RS08180	COG2340	Cysteine-rich secretory protein family
K7395_RS08185	COG1733	regulation of RNA biosynthetic process
K7395_RS08190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7395_RS08195	COG0571	ribonuclease III activity
K7395_RS08200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K7395_RS08215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K7395_RS08220	COG0742	ribosomal rna small subunit methyltransferase
K7395_RS08225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K7395_RS08230	COG1461	Dihydroxyacetone kinase
K7395_RS08235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K7395_RS08240	COG0351	phosphomethylpyrimidine kinase
K7395_RS08260	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7395_RS08265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K7395_RS08275	COG1920	GTP binding
K7395_RS08285	COG0776	regulation of translation
K7395_RS08295	COG0066	3-isopropylmalate dehydratase activity
K7395_RS08300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K7395_RS08305	COG1414	Transcriptional regulator
K7395_RS08350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7395_RS08355	COG0179	Fumarylacetoacetate (FAA) hydrolase
K7395_RS08365	COG5002	protein histidine kinase activity
K7395_RS08370	COG2018	Roadblock/LC7 domain
K7395_RS08390	COG2018	Roadblock/LC7 domain
K7395_RS08410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7395_RS08415	COG0366	Alpha amylase catalytic
K7395_RS08415	COG1470	cell adhesion involved in biofilm formation
K7395_RS08450	COG1725	Transcriptional regulator
K7395_RS08455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7395_RS08460	COG1120	ATPase activity
K7395_RS08465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS08470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS08520	COG0492	ferredoxin-NADP+ reductase activity
K7395_RS08545	COG2207	Transcriptional regulator
K7395_RS08545	COG3708	Transcriptional regulator
K7395_RS08555	COG1309	transcriptional regulator
K7395_RS08585	COG1472	Belongs to the glycosyl hydrolase 3 family
K7395_RS08595	COG0444	Belongs to the ABC transporter superfamily
K7395_RS08600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS08605	COG0601	transmembrane transport
K7395_RS08610	COG4608	Belongs to the ABC transporter superfamily
K7395_RS08620	COG1609	Transcriptional regulator
K7395_RS08625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7395_RS08635	COG2957	Belongs to the agmatine deiminase family
K7395_RS08640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K7395_RS08645	COG0473	3-isopropylmalate dehydrogenase activity
K7395_RS08660	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS08665	COG0506	proline dehydrogenase activity
K7395_RS08670	COG2508	Transcriptional regulator
K7395_RS08690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7395_RS08720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7395_RS08725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K7395_RS08730	COG0440	acetolactate synthase activity
K7395_RS08740	COG3300	MHYT domain
K7395_RS08740	COG5001	Diguanylate cyclase
K7395_RS08750	COG0667	Aldo Keto reductase
K7395_RS08755	COG2133	pyrroloquinoline quinone binding
K7395_RS08765	COG2197	response regulator
K7395_RS08785	COG2409	Drug exporters of the RND superfamily
K7395_RS08795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K7395_RS08800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K7395_RS08810	COG0154	amidase activity
K7395_RS08815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K7395_RS08825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K7395_RS08835	COG4221	oxidoreductase activity
K7395_RS08855	COG0482	sulfurtransferase activity
K7395_RS08890	COG0789	Transcriptional regulator
K7395_RS08900	COG2860	membrane
K7395_RS08905	COG3547	Transposase (IS116 IS110 IS902 family)
K7395_RS08910	COG2860	membrane
K7395_RS08915	COG4608	Belongs to the ABC transporter superfamily
K7395_RS08925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS08930	COG0601	transmembrane transport
K7395_RS08935	COG0747	negative chemotaxis
K7395_RS08955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K7395_RS08960	COG0509	glycine decarboxylation via glycine cleavage system
K7395_RS08965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7395_RS08970	COG1760	l-serine dehydratase
K7395_RS08980	COG0736	holo-[acyl-carrier-protein] synthase activity
K7395_RS09005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7395_RS09015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7395_RS09020	COG0019	diaminopimelate decarboxylase activity
K7395_RS09025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K7395_RS09030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7395_RS09040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS09055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7395_RS09070	COG4566	intracellular signal transduction
K7395_RS09080	COG0747	negative chemotaxis
K7395_RS09090	COG2319	Wd-40 repeat
K7395_RS09090	COG4249	Peptidase C14 caspase catalytic subunit p20
K7395_RS09105	COG2235	arginine
K7395_RS09110	COG0464	growth
K7395_RS09120	COG1506	peptidase
K7395_RS09120	COG0823	Involved in the tonB-independent uptake of proteins
K7395_RS09265	COG2197	response regulator
K7395_RS09280	COG1131	(ABC) transporter
K7395_RS09285	COG1132	(ABC) transporter
K7395_RS09290	COG1132	(ABC) transporter
K7395_RS09295	COG1597	lipid kinase activity
K7395_RS09345	COG0058	SHG alpha-glucan phosphorylase activity
K7395_RS09350	COG0366	Alpha amylase catalytic
K7395_RS09355	COG0366	Alpha amylase catalytic
K7395_RS09360	COG3281	Trehalose synthase
K7395_RS09365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K7395_RS09375	COG3118	belongs to the thioredoxin family
K7395_RS09390	COG1301	dicarboxylic acid transport
K7395_RS09395	COG3290	protein histidine kinase activity
K7395_RS09400	COG4565	transcriptional regulatory protein
K7395_RS09410	COG0205	6-phosphofructokinase activity
K7395_RS09415	COG0857	belongs to the CobB CobQ family
K7395_RS09415	COG0280	phosphate acetyltransferase
K7395_RS09420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K7395_RS09435	COG1595	DNA-templated transcription, initiation
K7395_RS09470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K7395_RS09475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7395_RS09475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7395_RS09510	COG1595	DNA-templated transcription, initiation
K7395_RS09555	COG5002	protein histidine kinase activity
K7395_RS09555	COG5000	phosphorelay sensor kinase activity
K7395_RS09560	COG0745	RESPONSE REGULATOR receiver
K7395_RS09575	COG0183	Belongs to the thiolase family
K7395_RS09595	COG1131	(ABC) transporter
K7395_RS09630	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
K7395_RS09645	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7395_RS09675	COG4585	Histidine kinase
K7395_RS09680	COG2197	response regulator
K7395_RS09695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K7395_RS09700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K7395_RS09705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K7395_RS09710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K7395_RS09715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K7395_RS09720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K7395_RS09725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K7395_RS09740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7395_RS09745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7395_RS09750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7395_RS09760	COG2890	protein-(glutamine-N5) methyltransferase activity
K7395_RS09765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K7395_RS09770	COG0254	rRNA binding
K7395_RS09775	COG1316	TRANSCRIPTIONal
K7395_RS09790	COG0083	homoserine kinase activity
K7395_RS09795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K7395_RS09800	COG0460	homoserine dehydrogenase
K7395_RS09805	COG0019	diaminopimelate decarboxylase activity
K7395_RS09810	COG0018	arginyl-trna synthetase
K7395_RS09840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7395_RS09845	COG3629	intracellular signal transduction
K7395_RS09845	COG3903	Transcriptional regulator
K7395_RS09855	COG3903	Transcriptional regulator
K7395_RS09855	COG3629	intracellular signal transduction
K7395_RS09870	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K7395_RS09875	COG1793	dna ligase
K7395_RS09875	COG3285	dna ligase
K7395_RS09895	COG2205	protein histidine kinase activity
K7395_RS09910	COG0768	penicillin binding
K7395_RS09935	COG1309	transcriptional regulator
K7395_RS09975	COG5002	protein histidine kinase activity
K7395_RS09990	COG0726	polysaccharide deacetylase
K7395_RS09995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K7395_RS10005	COG0745	RESPONSE REGULATOR receiver
K7395_RS10010	COG2205	protein histidine kinase activity
K7395_RS10015	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7395_RS10015	COG0567	Dehydrogenase, E1 component
K7395_RS10040	COG0542	response to heat
K7395_RS10060	COG0604	alcohol dehydrogenase
K7395_RS10065	COG0281	malic enzyme
K7395_RS10070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS10075	COG0765	amino acid transport
K7395_RS10080	COG1126	abc transporter atp-binding protein
K7395_RS10085	COG4106	trans-aconitate 2-methyltransferase activity
K7395_RS10130	COG4585	Histidine kinase
K7395_RS10135	COG2197	response regulator
K7395_RS10200	COG0142	geranyltranstransferase activity
K7395_RS10205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7395_RS10210	COG1959	2 iron, 2 sulfur cluster binding
K7395_RS10220	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K7395_RS10235	COG2172	sigma factor antagonist activity
K7395_RS10250	COG1597	lipid kinase activity
K7395_RS10265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7395_RS10270	COG0363	glucosamine-6-phosphate deaminase activity
K7395_RS10275	COG1472	Belongs to the glycosyl hydrolase 3 family
K7395_RS10280	COG0395	ABC-type sugar transport system, permease component
K7395_RS10285	COG1175	transmembrane transport
K7395_RS10290	COG2182	Extracellular solute-binding protein
K7395_RS10300	COG1966	Carbon starvation protein
K7395_RS10345	COG0242	peptide deformylase activity
K7395_RS10365	COG5662	AntiSigma factor
K7395_RS10370	COG1595	DNA-templated transcription, initiation
K7395_RS10380	COG2135	peptidase activity
K7395_RS10390	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K7395_RS10410	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7395_RS10420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K7395_RS10425	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7395_RS10435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K7395_RS10440	COG1162	GTPase activity
K7395_RS10445	COG2076	Multidrug Resistance protein
K7395_RS10455	COG0483	inositol monophosphate 1-phosphatase activity
K7395_RS10465	COG0753	catalase activity
K7395_RS10490	COG1615	UPF0182 protein
K7395_RS10500	COG3480	Lon protease (S16) C-terminal proteolytic domain
K7395_RS10550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K7395_RS10595	COG0210	DNA helicase
K7395_RS10685	COG0513	Belongs to the DEAD box helicase family
K7395_RS10695	COG1432	Conserved Protein
K7395_RS10705	COG2095	MarC family integral membrane protein
K7395_RS10720	COG2814	Major facilitator Superfamily
K7395_RS10730	COG0598	Magnesium transport protein CorA
K7395_RS10765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7395_RS10770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7395_RS10780	COG1595	DNA-templated transcription, initiation
K7395_RS10800	COG0519	Catalyzes the synthesis of GMP from XMP
K7395_RS10810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K7395_RS10815	COG1611	Belongs to the LOG family
K7395_RS10820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7395_RS10850	COG2912	Transglutaminase-like superfamily
K7395_RS10855	COG2197	response regulator
K7395_RS10860	COG1132	(ABC) transporter
K7395_RS10865	COG1132	(ABC) transporter
K7395_RS10875	COG0515	serine threonine protein kinase
K7395_RS10890	COG0110	maltose O-acetyltransferase activity
K7395_RS10915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7395_RS10935	COG4608	Belongs to the ABC transporter superfamily
K7395_RS10945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS10950	COG0601	transmembrane transport
K7395_RS10955	COG4166	transmembrane transport
K7395_RS10960	COG4608	Belongs to the ABC transporter superfamily
K7395_RS10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7395_RS10975	COG0601	transmembrane transport
K7395_RS10980	COG4166	transmembrane transport
K7395_RS10985	COG1217	gtp-binding protein TYPA
K7395_RS10995	COG1609	Transcriptional regulator
K7395_RS11010	COG1175	transmembrane transport
K7395_RS11015	COG0395	ABC-type sugar transport system, permease component
K7395_RS11120	COG0463	Glycosyl transferase, family 2
K7395_RS11130	COG1842	Phage shock protein A
K7395_RS11335	COG0012	GTP binding
K7395_RS11350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K7395_RS11360	COG1570	exodeoxyribonuclease VII activity
K7395_RS11365	COG1722	exodeoxyribonuclease VII activity
K7395_RS11370	COG0778	Nitroreductase
K7395_RS11395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K7395_RS11395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K7395_RS11410	COG3321	synthase
K7395_RS11410	COG0604	alcohol dehydrogenase
K7395_RS11420	COG1362	aminopeptidase activity
K7395_RS11435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS11445	COG0114	fumarate hydratase activity
K7395_RS11460	COG4499	WXG100 protein secretion system (Wss), protein YukC
K7395_RS11460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7395_RS11480	COG1136	(ABC) transporter
K7395_RS11495	COG0450	alkyl hydroperoxide reductase
K7395_RS11500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7395_RS11515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K7395_RS11525	COG0667	Aldo Keto reductase
K7395_RS11595	COG1404	Belongs to the peptidase S8 family
K7395_RS11635	COG2885	chlorophyll binding
K7395_RS11655	COG2197	response regulator
K7395_RS11660	COG3920	Histidine kinase
K7395_RS11690	COG2894	cell division
K7395_RS11730	COG2610	gluconate transmembrane transporter activity
K7395_RS11735	COG0251	oxidation-reduction process
K7395_RS11740	COG1414	Transcriptional regulator
K7395_RS11755	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K7395_RS11775	COG1733	regulation of RNA biosynthetic process
K7395_RS11795	COG0436	Aminotransferase
K7395_RS11825	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
K7395_RS11835	COG1331	Highly conserved protein containing a thioredoxin domain
K7395_RS11845	COG1309	transcriptional regulator
K7395_RS11850	COG0154	amidase activity
K7395_RS11880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7395_RS11890	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7395_RS11910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7395_RS11920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7395_RS11935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K7395_RS11940	COG2255	four-way junction helicase activity
K7395_RS11945	COG1595	DNA-templated transcription, initiation
K7395_RS11975	COG0583	DNA-binding transcription factor activity
K7395_RS11980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7395_RS11995	COG1396	sequence-specific DNA binding
K7395_RS12005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K7395_RS12025	COG1376	ErfK ybiS ycfS ynhG family protein
K7395_RS12050	COG1024	Enoyl-CoA hydratase
K7395_RS12065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7395_RS12075	COG0424	maF-like protein
K7395_RS12085	COG4770	biotin carboxylase activity
K7395_RS12115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7395_RS12130	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS12135	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS12170	COG1595	DNA-templated transcription, initiation
K7395_RS12175	COG0745	RESPONSE REGULATOR receiver
K7395_RS12180	COG2205	protein histidine kinase activity
K7395_RS12205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K7395_RS12220	COG0583	DNA-binding transcription factor activity
K7395_RS12225	COG2814	Major facilitator Superfamily
K7395_RS12245	COG1404	Belongs to the peptidase S8 family
K7395_RS12265	COG1079	Belongs to the binding-protein-dependent transport system permease family
K7395_RS12270	COG4603	Belongs to the binding-protein-dependent transport system permease family
K7395_RS12275	COG3845	ABC transporter
K7395_RS12280	COG1744	ABC transporter substrate-binding protein PnrA-like
K7395_RS12285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
K7395_RS12285	COG1473	amidohydrolase
K7395_RS12295	COG2089	acid synthase
K7395_RS12300	COG1083	cytidylyl-transferase
K7395_RS12310	COG1216	Glycosyl transferase, family 2
K7395_RS12340	COG1216	Glycosyl transferase, family 2
K7395_RS12365	COG1595	DNA-templated transcription, initiation
K7395_RS12375	COG0733	neurotransmitter:sodium symporter activity
K7395_RS12390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7395_RS12395	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K7395_RS12400	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K7395_RS12405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K7395_RS12440	COG2009	succinate dehydrogenase
K7395_RS12450	COG1053	succinate dehydrogenase
K7395_RS12455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K7395_RS12490	COG1408	metallophosphoesterase
K7395_RS12505	COG1295	ribonuclease BN
K7395_RS12525	COG0180	Tryptophanyl-tRNA synthetase
K7395_RS12530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7395_RS12535	COG0754	glutathionylspermidine amidase activity
K7395_RS12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7395_RS12550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7395_RS12555	COG0039	L-malate dehydrogenase activity
K7395_RS12570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K7395_RS12585	COG0138	bifunctional purine biosynthesis protein purh
K7395_RS12615	COG0045	succinate-CoA ligase (ADP-forming) activity
K7395_RS12630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K7395_RS12640	COG0714	Associated with various cellular activities
K7395_RS12660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7395_RS12670	COG0739	heme binding
K7395_RS12690	COG0791	NLP P60 protein
K7395_RS12700	COG2197	response regulator
K7395_RS12735	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K7395_RS12740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7395_RS12740	COG0519	Catalyzes the synthesis of GMP from XMP
K7395_RS12760	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS12765	COG2815	serine threonine protein kinase
K7395_RS12765	COG0515	serine threonine protein kinase
K7395_RS12770	COG0515	serine threonine protein kinase
K7395_RS12800	COG0516	GMP reductase activity
K7395_RS12810	COG1595	DNA-templated transcription, initiation
K7395_RS12825	COG0583	DNA-binding transcription factor activity
K7395_RS12840	COG2132	Multicopper oxidase
K7395_RS12850	COG1609	Transcriptional regulator
K7395_RS12865	COG0395	ABC-type sugar transport system, permease component
K7395_RS12880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K7395_RS12890	COG0726	polysaccharide deacetylase
K7395_RS12910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K7395_RS12935	COG0802	atpase or kinase
K7395_RS12945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K7395_RS12950	COG3189	MarR family transcriptional regulator
K7395_RS12955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K7395_RS12955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K7395_RS12960	COG0736	holo-[acyl-carrier-protein] synthase activity
K7395_RS12965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7395_RS12995	COG0596	Alpha beta hydrolase
K7395_RS13055	COG1072	(Pantothenic acid kinase))
K7395_RS13065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7395_RS13070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K7395_RS13075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K7395_RS13080	COG0488	(ABC) transporter
K7395_RS13090	COG0101	tRNA pseudouridine synthase activity
K7395_RS13095	COG0203	ribosomal protein L17
K7395_RS13100	COG0202	RNA polymerase activity
K7395_RS13105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K7395_RS13110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K7395_RS13115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K7395_RS13120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K7395_RS13130	COG0563	adenylate kinase activity
K7395_RS13140	COG0200	Binds to the 23S rRNA
K7395_RS13150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K7395_RS13155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K7395_RS13160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K7395_RS13165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K7395_RS13170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7395_RS13175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K7395_RS13180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K7395_RS13185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K7395_RS13190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K7395_RS13195	COG0255	Belongs to the universal ribosomal protein uL29 family
K7395_RS13200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K7395_RS13205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K7395_RS13210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K7395_RS13215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K7395_RS13220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K7395_RS13225	COG0089	rRNA binding
K7395_RS13230	COG0088	Forms part of the polypeptide exit tunnel
K7395_RS13235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K7395_RS13240	COG0051	transcription antitermination factor activity, RNA binding
K7395_RS13260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7395_RS13265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7395_RS13270	COG0049	tRNA binding
K7395_RS13275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K7395_RS13285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K7395_RS13290	COG0085	RNA polymerase activity
K7395_RS13295	COG0222	ribosome binding
K7395_RS13300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K7395_RS13310	COG0081	regulation of translation
K7395_RS13315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K7395_RS13335	COG0436	Aminotransferase
K7395_RS13340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K7395_RS13355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K7395_RS13360	COG0477	Major facilitator Superfamily
K7395_RS13375	COG2030	dehydratase
K7395_RS13380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K7395_RS13400	COG0702	epimerase
K7395_RS13410	COG1666	GTP binding
K7395_RS13420	COG0640	Transcriptional regulator
K7395_RS13425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7395_RS13440	COG3304	Inner membrane component domain
K7395_RS13445	COG0501	Belongs to the peptidase M48B family
K7395_RS13455	COG1007	ATP synthesis coupled electron transport
K7395_RS13465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7395_RS13470	COG0713	ATP synthesis coupled electron transport
K7395_RS13475	COG0839	Belongs to the complex I subunit 6 family
K7395_RS13480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K7395_RS13490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13520	COG0674	pyruvate-flavodoxin oxidoreductase activity
K7395_RS13520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K7395_RS13525	COG1013	pyruvate-flavodoxin oxidoreductase activity
K7395_RS13530	COG0702	epimerase
K7395_RS13590	COG0561	phosphatase activity
K7395_RS13610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7395_RS13620	COG0515	serine threonine protein kinase
K7395_RS13620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7395_RS13640	COG1131	(ABC) transporter
K7395_RS13650	COG0142	geranyltranstransferase activity
K7395_RS13655	COG3104	oligopeptide transport
K7395_RS13665	COG0179	Fumarylacetoacetate (FAA) hydrolase
K7395_RS13680	COG0514	ATP-dependent DNA helicase (RecQ)
K7395_RS13685	COG1007	ATP synthesis coupled electron transport
K7395_RS13695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7395_RS13700	COG0713	ATP synthesis coupled electron transport
K7395_RS13705	COG0839	Belongs to the complex I subunit 6 family
K7395_RS13710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K7395_RS13720	COG1034	ATP synthesis coupled electron transport
K7395_RS13725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K7395_RS13735	COG0649	NAD binding
K7395_RS13740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7395_RS13770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K7395_RS13790	COG2226	methyltransferase
K7395_RS13815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K7395_RS13825	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K7395_RS13830	COG1278	Cold shock
K7395_RS13870	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS13910	COG1309	transcriptional regulator
K7395_RS13920	COG1960	acyl-CoA dehydrogenase activity
K7395_RS13940	COG0259	pyridoxamine-phosphate oxidase activity
K7395_RS13945	COG0501	Belongs to the peptidase M48B family
K7395_RS13980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS13985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS13990	COG4592	Periplasmic binding protein
K7395_RS13995	COG2072	flavoprotein involved in K transport
K7395_RS14030	COG0640	Transcriptional regulator
K7395_RS14050	COG1024	Enoyl-CoA hydratase
K7395_RS14070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K7395_RS14100	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K7395_RS14105	COG1960	acyl-CoA dehydrogenase activity
K7395_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS14125	COG1960	acyl-CoA dehydrogenase activity
K7395_RS14130	COG1960	acyl-CoA dehydrogenase activity
K7395_RS14140	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS14150	COG1366	Belongs to the anti-sigma-factor antagonist family
K7395_RS14195	COG1131	(ABC) transporter
K7395_RS14205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7395_RS14215	COG4821	SIS domain
K7395_RS14220	COG2205	protein histidine kinase activity
K7395_RS14225	COG0745	RESPONSE REGULATOR receiver
K7395_RS14240	COG0577	efflux transmembrane transporter activity
K7395_RS14240	COG1136	(ABC) transporter
K7395_RS14245	COG0577	efflux transmembrane transporter activity
K7395_RS14245	COG1136	(ABC) transporter
K7395_RS14255	COG0259	pyridoxamine-phosphate oxidase activity
K7395_RS14295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7395_RS14340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K7395_RS14395	COG1024	Enoyl-CoA hydratase
K7395_RS14400	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS14415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7395_RS14440	COG1131	(ABC) transporter
K7395_RS14450	COG2274	protein secretion by the type I secretion system
K7395_RS14475	COG1051	belongs to the nudix hydrolase family
K7395_RS14485	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
K7395_RS14495	COG0583	DNA-binding transcription factor activity
K7395_RS14500	COG0247	lactate metabolic process
K7395_RS14500	COG0277	FAD linked oxidase domain protein
K7395_RS14505	COG2205	protein histidine kinase activity
K7395_RS14535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K7395_RS14540	COG0675	Transposase, IS605 OrfB family
K7395_RS14565	COG1335	isochorismatase
K7395_RS14630	COG0697	spore germination
K7395_RS14645	COG1309	transcriptional regulator
K7395_RS14660	COG2205	protein histidine kinase activity
K7395_RS14665	COG0745	RESPONSE REGULATOR receiver
K7395_RS14680	COG0577	efflux transmembrane transporter activity
K7395_RS14680	COG1136	(ABC) transporter
K7395_RS14685	COG0577	efflux transmembrane transporter activity
K7395_RS14685	COG1136	(ABC) transporter
K7395_RS14795	COG0583	DNA-binding transcription factor activity
K7395_RS14800	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS14810	COG0515	serine threonine protein kinase
K7395_RS14820	COG2267	carboxylic ester hydrolase activity
K7395_RS14825	COG0667	Aldo Keto reductase
K7395_RS14855	COG2252	PERMEase
K7395_RS14865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7395_RS14890	COG2814	Major facilitator Superfamily
K7395_RS14900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K7395_RS14905	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K7395_RS14930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS14935	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS14940	COG1120	ATPase activity
K7395_RS14945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7395_RS14985	COG1061	Type III restriction enzyme res subunit
K7395_RS14995	COG3973	AAA domain
K7395_RS15010	COG1984	allophanate hydrolase subunit 2
K7395_RS15020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K7395_RS15060	COG1737	Transcriptional regulator
K7395_RS15065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K7395_RS15070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7395_RS15070	COG1263	PTS System
K7395_RS15075	COG0477	Major facilitator Superfamily
K7395_RS15125	COG1175	transmembrane transport
K7395_RS15130	COG0395	ABC-type sugar transport system, permease component
K7395_RS15220	COG1846	Transcriptional regulator
K7395_RS15235	COG1595	DNA-templated transcription, initiation
K7395_RS15250	COG1132	(ABC) transporter
K7395_RS15300	COG0463	Glycosyl transferase, family 2
K7395_RS15305	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K7395_RS15315	COG1131	(ABC) transporter
K7395_RS15355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7395_RS15360	COG1960	acyl-CoA dehydrogenase activity
K7395_RS15365	COG0019	diaminopimelate decarboxylase activity
K7395_RS15405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7395_RS15420	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K7395_RS15425	COG1051	belongs to the nudix hydrolase family
K7395_RS15430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7395_RS15450	COG1132	(ABC) transporter
K7395_RS15460	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K7395_RS15545	COG0494	nUDIX hydrolase
K7395_RS15570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K7395_RS15575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K7395_RS15580	COG1754	DNA topoisomerase type I activity
K7395_RS15580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7395_RS15590	COG2890	protein-(glutamine-N5) methyltransferase activity
K7395_RS15600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K7395_RS15605	COG2172	sigma factor antagonist activity
K7395_RS15610	COG1366	Belongs to the anti-sigma-factor antagonist family
K7395_RS15615	COG1205	dead DEAH box helicase
K7395_RS15615	COG1111	helicase
K7395_RS15675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7395_RS15680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K7395_RS15690	COG2267	carboxylic ester hydrolase activity
K7395_RS15720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7395_RS15745	COG0003	Pfam Anion-transporting ATPase
K7395_RS15755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K7395_RS15760	COG1610	YqeY-like protein
K7395_RS15765	COG1408	metallophosphoesterase
K7395_RS15785	COG2226	methyltransferase
K7395_RS15790	COG0640	Transcriptional regulator
K7395_RS15795	COG0798	PFAM Bile acid sodium symporter
K7395_RS15800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7395_RS15815	COG2755	lipolytic protein G-D-S-L family
K7395_RS15825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7395_RS15845	COG1595	DNA-templated transcription, initiation
K7395_RS15880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K7395_RS15885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K7395_RS15900	COG1802	Transcriptional regulator
K7395_RS15905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7395_RS15910	COG0693	protein deglycase activity
K7395_RS15920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7395_RS15920	COG0515	serine threonine protein kinase
K7395_RS15935	COG3226	Transcriptional regulator
K7395_RS15985	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K7395_RS16050	COG0592	DNA-directed DNA polymerase activity
K7395_RS16065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K7395_RS16090	COG2197	response regulator
K7395_RS16095	COG4585	Histidine kinase
K7395_RS16100	COG0702	epimerase
K7395_RS16110	COG3844	kynureninase activity
K7395_RS16125	COG0477	Major facilitator Superfamily
K7395_RS16130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K7395_RS16135	COG0191	fructose-bisphosphate aldolase activity
K7395_RS16140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K7395_RS16155	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K7395_RS16180	COG2197	response regulator
K7395_RS16195	COG0745	RESPONSE REGULATOR receiver
K7395_RS16200	COG2205	protein histidine kinase activity
K7395_RS16205	COG1131	(ABC) transporter
K7395_RS16215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7395_RS16245	COG2329	Antibiotic biosynthesis monooxygenase
K7395_RS16255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K7395_RS16260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS16270	COG0542	response to heat
K7395_RS16300	COG0789	Transcriptional regulator
K7395_RS16305	COG0484	heat shock protein binding
K7395_RS16310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K7395_RS16315	COG0443	Heat shock 70 kDa protein
K7395_RS16320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7395_RS16325	COG2181	nitrate reductase activity
K7395_RS16325	COG0247	lactate metabolic process
K7395_RS16345	COG0717	Belongs to the dCTP deaminase family
K7395_RS16415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K7395_RS16470	COG0277	FAD linked oxidase domain protein
K7395_RS16520	COG0137	argininosuccinate synthase activity
K7395_RS16585	COG3851	Histidine kinase
K7395_RS16600	COG2197	response regulator
K7395_RS16650	COG2205	protein histidine kinase activity
K7395_RS16655	COG0745	RESPONSE REGULATOR receiver
K7395_RS16670	COG4585	Histidine kinase
K7395_RS16675	COG2197	response regulator
K7395_RS16700	COG2124	cytochrome p450
K7395_RS16705	COG2124	cytochrome p450
K7395_RS16710	COG1024	Enoyl-CoA hydratase
K7395_RS16730	COG3585	molybdate ion transport
K7395_RS16755	COG0531	amino acid
K7395_RS16765	COG0475	glutathione-regulated potassium exporter activity
K7395_RS16770	COG2409	Drug exporters of the RND superfamily
K7395_RS16775	COG3594	Acyltransferase
K7395_RS16785	COG0513	Belongs to the DEAD box helicase family
K7395_RS16790	COG1278	Cold shock
K7395_RS16855	COG2268	Band 7 protein
K7395_RS16875	COG0640	Transcriptional regulator
K7395_RS16890	COG0659	secondary active sulfate transmembrane transporter activity
K7395_RS16920	COG2072	flavoprotein involved in K transport
K7395_RS16925	COG0798	PFAM Bile acid sodium symporter
K7395_RS16935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7395_RS16940	COG0492	ferredoxin-NADP+ reductase activity
K7395_RS16960	COG4941	Belongs to the sigma-70 factor family
K7395_RS16985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K7395_RS17025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K7395_RS17045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7395_RS17075	COG1191	sigma factor activity
K7395_RS17080	COG1191	sigma factor activity
K7395_RS17105	COG2353	YceI-like domain
K7395_RS17110	COG3467	pyridoxamine 5'-phosphate
K7395_RS17125	COG0477	Major facilitator Superfamily
K7395_RS17140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K7395_RS17150	COG2205	protein histidine kinase activity
K7395_RS17155	COG0745	RESPONSE REGULATOR receiver
K7395_RS17175	COG1595	DNA-templated transcription, initiation
K7395_RS17185	COG3903	Transcriptional regulator
K7395_RS17185	COG3629	intracellular signal transduction
K7395_RS17210	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS17215	COG1595	DNA-templated transcription, initiation
K7395_RS17240	COG1960	acyl-CoA dehydrogenase activity
K7395_RS17255	COG3693	PFAM glycoside hydrolase, family 10
K7395_RS17295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7395_RS17310	COG0653	protein targeting
K7395_RS17330	COG0006	proline dipeptidase activity
K7395_RS17350	COG1999	signal sequence binding
K7395_RS17360	COG2372	response to copper ion
K7395_RS17365	COG2837	iron assimilation
K7395_RS17375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K7395_RS17380	COG0561	phosphatase activity
K7395_RS17405	COG1131	(ABC) transporter
K7395_RS17420	COG0789	Transcriptional regulator
K7395_RS17425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
K7395_RS17435	COG0561	phosphatase activity
K7395_RS17445	COG4988	ABC transporter
K7395_RS17450	COG1294	oxidase, subunit
K7395_RS17455	COG1271	oxidase subunit
K7395_RS17460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7395_RS17465	COG1609	Transcriptional regulator
K7395_RS17470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K7395_RS17480	COG3152	Membrane
K7395_RS17485	COG1733	regulation of RNA biosynthetic process
K7395_RS17495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K7395_RS17520	COG0662	Cupin 2, conserved barrel domain protein
K7395_RS17525	COG1950	PFAM Membrane protein of
K7395_RS17530	COG0626	cystathionine gamma-synthase activity
K7395_RS17550	COG2814	Major facilitator Superfamily
K7395_RS17580	COG0596	Alpha beta hydrolase
K7395_RS17585	COG1309	transcriptional regulator
K7395_RS17590	COG0305	Participates in initiation and elongation during chromosome replication
K7395_RS17600	COG0359	binds to the 23S rRNA
K7395_RS17605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K7395_RS17610	COG0629	single-stranded DNA binding
K7395_RS17615	COG0360	Binds together with S18 to 16S ribosomal RNA
K7395_RS17640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7395_RS17660	COG0617	tRNA 3'-terminal CCA addition
K7395_RS17675	COG2815	serine threonine protein kinase
K7395_RS17675	COG0515	serine threonine protein kinase
K7395_RS17690	COG1595	DNA-templated transcription, initiation
K7395_RS17700	COG0492	ferredoxin-NADP+ reductase activity
K7395_RS17705	COG3118	belongs to the thioredoxin family
K7395_RS17720	COG1192	Involved in chromosome partitioning
K7395_RS17725	COG0357	Ribosomal RNA small subunit methyltransferase G
K7395_RS17735	COG0706	membrane insertase activity
K7395_RS17740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K7395_RS17745	COG0594	ribonuclease P activity
K7395_RS17750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K7395_RS17760	COG0592	DNA-directed DNA polymerase activity
K7395_RS17765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K7395_RS17770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7395_RS17775	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
K7395_RS17785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7395_RS17825	COG0515	serine threonine protein kinase
K7395_RS17855	COG0705	Rhomboid family
K7395_RS17870	COG3764	Sortase (surface protein transpeptidase)
K7395_RS17885	COG3764	Sortase (surface protein transpeptidase)
K7395_RS17890	COG3764	Sortase (surface protein transpeptidase)
K7395_RS17900	COG0515	serine threonine protein kinase
K7395_RS17905	COG0768	penicillin binding
K7395_RS17920	COG1716	ATPase activity
K7395_RS17925	COG1716	ATPase activity
K7395_RS17940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K7395_RS17945	COG1733	regulation of RNA biosynthetic process
K7395_RS17970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K7395_RS17975	COG2151	metal-sulfur cluster biosynthetic enzyme
K7395_RS17980	COG3396	Phenylacetate-CoA oxygenase
K7395_RS17985	COG3460	Phenylacetate-CoA oxygenase
K7395_RS17990	COG3396	Phenylacetate-CoA oxygenase
K7395_RS18015	COG1309	transcriptional regulator
K7395_RS18020	COG1522	sequence-specific DNA binding
K7395_RS18055	COG0604	alcohol dehydrogenase
K7395_RS18070	COG4591	ABC-type transport system involved in lipoprotein release permease component
K7395_RS18070	COG1136	(ABC) transporter
K7395_RS18085	COG0515	serine threonine protein kinase
K7395_RS18090	COG0515	serine threonine protein kinase
K7395_RS18115	COG0022	dehydrogenase e1 component
K7395_RS18120	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7395_RS18140	COG1802	Transcriptional regulator
K7395_RS18145	COG2271	Major facilitator Superfamily
K7395_RS18155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7395_RS18175	COG3629	intracellular signal transduction
K7395_RS18175	COG3903	Transcriptional regulator
K7395_RS18185	COG1362	aminopeptidase activity
K7395_RS18190	COG1960	acyl-CoA dehydrogenase activity
K7395_RS18200	COG1741	Belongs to the pirin family
K7395_RS18210	COG1366	Belongs to the anti-sigma-factor antagonist family
K7395_RS18210	COG2208	phosphoserine phosphatase activity
K7395_RS18210	COG2172	sigma factor antagonist activity
K7395_RS18215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K7395_RS18225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7395_RS18230	COG0745	RESPONSE REGULATOR receiver
K7395_RS18235	COG2205	protein histidine kinase activity
K7395_RS18240	COG2304	oxidoreductase activity
K7395_RS18270	COG0431	NADPH-dependent FMN reductase
K7395_RS18290	COG1672	PFAM Archaeal ATPase
K7395_RS18290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K7395_RS18305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7395_RS18315	COG0180	Tryptophanyl-tRNA synthetase
K7395_RS18325	COG2255	four-way junction helicase activity
K7395_RS18350	COG0475	glutathione-regulated potassium exporter activity
K7395_RS18355	COG0490	domain, Protein
K7395_RS18380	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K7395_RS18465	COG0151	Belongs to the GarS family
K7395_RS18480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K7395_RS18490	COG2197	response regulator
K7395_RS18525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7395_RS18530	COG0047	phosphoribosylformylglycinamidine synthase activity
K7395_RS18535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7395_RS18545	COG1196	nuclear chromosome segregation
K7395_RS18545	COG0741	lytic transglycosylase activity
K7395_RS18545	COG0739	heme binding
K7395_RS18565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K7395_RS18600	COG1643	Atp-dependent helicase
K7395_RS18610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7395_RS18610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K7395_RS18615	COG0785	Cytochrome C biogenesis protein
K7395_RS18620	COG3639	organic phosphonate transmembrane transporter activity
K7395_RS18625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K7395_RS18630	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K7395_RS18635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS18650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS18660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS18665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K7395_RS18690	COG2746	aminoglycoside 3-N-acetyltransferase activity
K7395_RS18700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7395_RS18745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7395_RS18750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7395_RS18760	COG0513	Belongs to the DEAD box helicase family
K7395_RS18805	COG2079	MmgE PrpD family protein
K7395_RS18810	COG1396	sequence-specific DNA binding
K7395_RS18810	COG3800	Transcriptional regulator
K7395_RS18815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K7395_RS18825	COG0789	Transcriptional regulator
K7395_RS18835	COG0739	heme binding
K7395_RS18835	COG1196	nuclear chromosome segregation
K7395_RS18835	COG0741	lytic transglycosylase activity
K7395_RS18840	COG0667	Aldo Keto reductase
K7395_RS18850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K7395_RS18855	COG0579	oxidoreductase
K7395_RS18880	COG1252	NADH dehydrogenase
K7395_RS18895	COG1846	Transcriptional regulator
K7395_RS18915	COG2197	response regulator
K7395_RS18920	COG4585	Histidine kinase
K7395_RS18930	COG1131	(ABC) transporter
K7395_RS19000	COG1196	nuclear chromosome segregation
K7395_RS19000	COG0739	heme binding
K7395_RS19000	COG0741	lytic transglycosylase activity
K7395_RS19005	COG0671	phosphoesterase, PA-phosphatase related
K7395_RS19025	COG1937	Protein conserved in bacteria
K7395_RS19035	COG0306	phosphate transporter
K7395_RS19055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7395_RS19060	COG0406	alpha-ribazole phosphatase activity
K7395_RS19060	COG0494	nUDIX hydrolase
K7395_RS19085	COG1725	Transcriptional regulator
K7395_RS19095	COG0456	acetyltransferase
K7395_RS19100	COG0737	Belongs to the 5'-nucleotidase family
K7395_RS19115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS19130	COG1335	isochorismatase
K7395_RS19160	COG0739	heme binding
K7395_RS19180	COG3311	Transcriptional regulator
K7395_RS19185	COG1569	PIN domain
K7395_RS19200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7395_RS19205	COG1609	Transcriptional regulator
K7395_RS19210	COG0745	RESPONSE REGULATOR receiver
K7395_RS19235	COG2897	thiosulfate sulfurtransferase activity
K7395_RS19270	COG3485	protocatechuate 3,4-dioxygenase
K7395_RS19275	COG0735	belongs to the Fur family
K7395_RS19285	COG1490	D-aminoacyl-tRNA deacylase activity
K7395_RS19300	COG4552	Acetyltransferase involved in intracellular survival and related
K7395_RS19335	COG0583	DNA-binding transcription factor activity
K7395_RS19345	COG0667	Aldo Keto reductase
K7395_RS19395	COG0438	transferase activity, transferring glycosyl groups
K7395_RS19440	COG0588	phosphoglycerate mutase activity
K7395_RS19460	COG5002	protein histidine kinase activity
K7395_RS19475	COG1329	Transcriptional regulator
K7395_RS19480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K7395_RS19485	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K7395_RS19490	COG3467	pyridoxamine 5'-phosphate
K7395_RS19495	COG0215	cysteine-tRNA ligase activity
K7395_RS19510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K7395_RS19520	COG3842	ATPase activity
K7395_RS19535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS19555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7395_RS19600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7395_RS19610	COG0165	Argininosuccinate lyase
K7395_RS19630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS19670	COG0515	serine threonine protein kinase
K7395_RS19670	COG2815	serine threonine protein kinase
K7395_RS19725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7395_RS19740	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K7395_RS19760	COG1131	(ABC) transporter
K7395_RS19775	COG2197	response regulator
K7395_RS19780	COG4585	Histidine kinase
K7395_RS19790	COG0666	response to abiotic stimulus
K7395_RS19815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K7395_RS19845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7395_RS19850	COG1940	carbohydrate kinase activity
K7395_RS19880	COG1595	DNA-templated transcription, initiation
K7395_RS19925	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS19970	COG0076	glutamate decarboxylase activity
K7395_RS19975	COG0655	NAD(P)H dehydrogenase (quinone) activity
K7395_RS19985	COG0393	Putative heavy-metal-binding
K7395_RS19990	COG0586	Pfam SNARE associated Golgi protein
K7395_RS20000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7395_RS20005	COG2027	D-alanyl-D-alanine carboxypeptidase
K7395_RS20015	COG0037	tRNA processing
K7395_RS20030	COG0302	gtp cyclohydrolase
K7395_RS20040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7395_RS20045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K7395_RS20060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K7395_RS20060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K7395_RS20070	COG0517	IMP dehydrogenase activity
K7395_RS20070	COG1125	glycine betaine transport
K7395_RS20075	COG1174	glycine betaine transport
K7395_RS20080	COG1174	glycine betaine transport
K7395_RS20085	COG1732	Glycine betaine
K7395_RS20095	COG0649	NAD binding
K7395_RS20110	COG2197	response regulator
K7395_RS20135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K7395_RS20140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K7395_RS20150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K7395_RS20170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K7395_RS20200	COG0739	heme binding
K7395_RS20205	COG2205	protein histidine kinase activity
K7395_RS20210	COG0745	RESPONSE REGULATOR receiver
K7395_RS20220	COG1595	DNA-templated transcription, initiation
K7395_RS20225	COG1194	a g-specific adenine glycosylase
K7395_RS20235	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K7395_RS20255	COG0248	Ppx GppA phosphatase
K7395_RS20260	COG1082	Xylose isomerase domain protein TIM barrel
K7395_RS20270	COG0129	dihydroxy-acid dehydratase activity
K7395_RS20275	COG0515	serine threonine protein kinase
K7395_RS20275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7395_RS20280	COG4991	sh3 domain protein
K7395_RS20290	COG0842	Transport permease protein
K7395_RS20290	COG1129	ABC transporter
K7395_RS20300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7395_RS20320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS20325	COG2223	nitrite transmembrane transporter activity
K7395_RS20380	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K7395_RS20385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K7395_RS20390	COG0181	hydroxymethylbilane synthase activity
K7395_RS20395	COG1648	precorrin-2 dehydrogenase activity
K7395_RS20395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K7395_RS20400	COG0113	porphobilinogen synthase activity
K7395_RS20425	COG0702	epimerase
K7395_RS20430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K7395_RS20450	COG0018	arginyl-trna synthetase
K7395_RS20455	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K7395_RS20475	COG1690	Belongs to the RtcB family
K7395_RS20480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K7395_RS20490	COG2188	Transcriptional regulator
K7395_RS20510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K7395_RS20525	COG1116	anion transmembrane transporter activity
K7395_RS20555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7395_RS20560	COG0406	alpha-ribazole phosphatase activity
K7395_RS20565	COG2382	esterase
K7395_RS20580	COG0785	Cytochrome C biogenesis protein
K7395_RS20585	COG1333	cytochrome c biogenesis protein
K7395_RS20590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K7395_RS20600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K7395_RS20615	COG0163	prenyltransferase activity
K7395_RS20655	COG1309	transcriptional regulator
K7395_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS20760	COG0667	Aldo Keto reductase
K7395_RS20770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7395_RS20775	COG1802	Transcriptional regulator
K7395_RS20780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7395_RS20795	COG0395	ABC-type sugar transport system, permease component
K7395_RS20815	COG1653	transport
K7395_RS20820	COG2755	lipolytic protein G-D-S-L family
K7395_RS20825	COG3866	Pectate lyase
K7395_RS20855	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K7395_RS20895	COG0768	penicillin binding
K7395_RS20925	COG0477	Major facilitator Superfamily
K7395_RS20935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K7395_RS20950	COG0667	Aldo Keto reductase
K7395_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS21045	COG1686	Belongs to the peptidase S11 family
K7395_RS21080	COG1115	amino acid carrier protein
K7395_RS21095	COG1309	transcriptional regulator
K7395_RS21125	COG1846	Transcriptional regulator
K7395_RS21130	COG3384	dioxygenase
K7395_RS21150	COG0477	Major facilitator Superfamily
K7395_RS21170	COG0243	molybdopterin cofactor binding
K7395_RS21175	COG0437	4 iron, 4 sulfur cluster binding
K7395_RS21195	COG1970	mechanosensitive ion channel activity
K7395_RS21205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K7395_RS21220	COG3263	regulation of cellular component size
K7395_RS21230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K7395_RS21235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K7395_RS21245	COG0315	cyclic pyranopterin monophosphate synthase activity
K7395_RS21250	COG0521	Mo-molybdopterin cofactor biosynthetic process
K7395_RS21255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7395_RS21290	COG1132	(ABC) transporter
K7395_RS21295	COG1132	(ABC) transporter
K7395_RS21310	COG1834	amidinotransferase
K7395_RS21315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7395_RS21320	COG1073	alpha beta
K7395_RS21410	COG0708	Exodeoxyribonuclease III
K7395_RS21420	COG2072	flavoprotein involved in K transport
K7395_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS21445	COG4946	Tricorn protease homolog
K7395_RS21445	COG0793	Belongs to the peptidase S41A family
K7395_RS21455	COG2409	Drug exporters of the RND superfamily
K7395_RS21465	COG0310	cobalt ion transport
K7395_RS21475	COG1122	ATPase activity
K7395_RS21480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7395_RS21500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7395_RS21505	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
K7395_RS21520	COG2249	NAD(P)H dehydrogenase (quinone) activity
K7395_RS21555	COG1115	amino acid carrier protein
K7395_RS21570	COG0442	prolyl-tRNA aminoacylation
K7395_RS21600	COG2207	Transcriptional regulator
K7395_RS21605	COG2223	nitrite transmembrane transporter activity
K7395_RS21645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7395_RS21675	COG0084	hydrolase, TatD family'
K7395_RS21685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K7395_RS21690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K7395_RS21700	COG4115	mRNA cleavage
K7395_RS21705	COG2161	toxin-antitoxin pair type II binding
K7395_RS21725	COG2197	response regulator
K7395_RS21730	COG0488	(ABC) transporter
K7395_RS21760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7395_RS21775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K7395_RS21785	COG2197	response regulator
K7395_RS21790	COG1846	Transcriptional regulator
K7395_RS21795	COG4106	trans-aconitate 2-methyltransferase activity
K7395_RS21820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K7395_RS21830	COG0193	aminoacyl-tRNA hydrolase activity
K7395_RS21835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K7395_RS21840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K7395_RS21845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K7395_RS21855	COG4585	Histidine kinase
K7395_RS21885	COG0667	Aldo Keto reductase
K7395_RS21890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7395_RS21895	COG2124	cytochrome p450
K7395_RS21900	COG2124	cytochrome p450
K7395_RS21945	COG0346	lactoylglutathione lyase activity
K7395_RS21950	COG0640	Transcriptional regulator
K7395_RS21960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7395_RS21965	COG3226	Transcriptional regulator
K7395_RS21970	COG0477	Major facilitator Superfamily
K7395_RS21975	COG1136	(ABC) transporter
K7395_RS21980	COG0577	efflux transmembrane transporter activity
K7395_RS22030	COG1335	isochorismatase
K7395_RS22050	COG2815	serine threonine protein kinase
K7395_RS22050	COG0515	serine threonine protein kinase
K7395_RS22075	COG1652	LysM domain
K7395_RS22085	COG0148	phosphopyruvate hydratase activity
K7395_RS22105	COG1252	NADH dehydrogenase
K7395_RS22110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7395_RS22115	COG0577	efflux transmembrane transporter activity
K7395_RS22115	COG1136	(ABC) transporter
K7395_RS22120	COG0577	efflux transmembrane transporter activity
K7395_RS22120	COG1136	(ABC) transporter
K7395_RS22145	COG0183	Belongs to the thiolase family
K7395_RS22150	COG2755	lipolytic protein G-D-S-L family
K7395_RS22175	COG3409	Peptidoglycan-binding domain 1 protein
K7395_RS22180	COG0577	efflux transmembrane transporter activity
K7395_RS22180	COG1136	(ABC) transporter
K7395_RS22185	COG0577	efflux transmembrane transporter activity
K7395_RS22185	COG1136	(ABC) transporter
K7395_RS22230	COG0531	amino acid
K7395_RS22235	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K7395_RS22250	COG1228	amidohydrolase
K7395_RS22260	COG1191	sigma factor activity
K7395_RS22265	COG1366	Belongs to the anti-sigma-factor antagonist family
K7395_RS22295	COG3104	oligopeptide transport
K7395_RS22300	COG0745	RESPONSE REGULATOR receiver
K7395_RS22305	COG2205	protein histidine kinase activity
K7395_RS22335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K7395_RS22390	COG2226	methyltransferase
K7395_RS22450	COG1316	TRANSCRIPTIONal
K7395_RS22460	COG1316	TRANSCRIPTIONal
K7395_RS22470	COG1316	TRANSCRIPTIONal
K7395_RS22475	COG1316	TRANSCRIPTIONal
K7395_RS22480	COG1316	TRANSCRIPTIONal
K7395_RS22495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K7395_RS22505	COG0778	Nitroreductase
K7395_RS22505	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K7395_RS22510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K7395_RS22545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7395_RS22550	COG2835	tetraacyldisaccharide 4'-kinase activity
K7395_RS22560	COG1482	cell wall glycoprotein biosynthetic process
K7395_RS22570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K7395_RS22610	COG0714	Associated with various cellular activities
K7395_RS22630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K7395_RS22710	COG0745	RESPONSE REGULATOR receiver
K7395_RS22715	COG5002	protein histidine kinase activity
K7395_RS22715	COG5000	phosphorelay sensor kinase activity
K7395_RS22720	COG0823	Involved in the tonB-independent uptake of proteins
K7395_RS22725	COG1040	competence protein
K7395_RS22730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K7395_RS22735	COG2197	response regulator
K7395_RS22750	COG0653	protein targeting
K7395_RS22775	COG2902	Dehydrogenase
K7395_RS22780	COG1134	teichoic acid transport
K7395_RS22790	COG1309	transcriptional regulator
K7395_RS22800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K7395_RS22805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K7395_RS22810	COG1073	alpha beta
K7395_RS22810	COG2226	methyltransferase
K7395_RS22815	COG4122	O-methyltransferase activity
K7395_RS22820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K7395_RS22825	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K7395_RS22830	COG0438	transferase activity, transferring glycosyl groups
K7395_RS22835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K7395_RS22840	COG0395	ABC-type sugar transport system, permease component
K7395_RS22845	COG1175	transmembrane transport
K7395_RS22850	COG1653	transport
K7395_RS22860	COG0515	serine threonine protein kinase
K7395_RS22865	COG0515	serine threonine protein kinase
K7395_RS22870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K7395_RS22885	COG2884	Cell division ATP-binding protein ftsE
K7395_RS22890	COG2177	Part of the ABC transporter FtsEX involved in
K7395_RS22895	COG0793	Belongs to the peptidase S41A family
K7395_RS22900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K7395_RS22925	COG0583	DNA-binding transcription factor activity
K7395_RS22945	COG2223	nitrite transmembrane transporter activity
K7395_RS22975	COG3973	AAA domain
K7395_RS22975	COG3973	AAA domain
K7395_RS22985	COG0776	regulation of translation
K7395_RS23000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7395_RS23005	COG1678	Uncharacterized ACR, COG1678
K7395_RS23020	COG1175	transmembrane transport
K7395_RS23025	COG0395	ABC-type sugar transport system, permease component
K7395_RS23030	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K7395_RS23080	COG2814	Major facilitator Superfamily
K7395_RS23090	COG3654	unkown
K7395_RS23105	COG3480	Lon protease (S16) C-terminal proteolytic domain
K7395_RS23120	COG1732	Glycine betaine
K7395_RS23125	COG1174	glycine betaine transport
K7395_RS23135	COG1174	glycine betaine transport
K7395_RS23145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K7395_RS23155	COG0277	FAD linked oxidase domain protein
K7395_RS23190	COG1335	isochorismatase
K7395_RS23200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K7395_RS23210	COG1113	amino acid transport
K7395_RS23225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS23260	COG1263	PTS System
K7395_RS23265	COG1263	PTS System
K7395_RS23270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K7395_RS23275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K7395_RS23285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K7395_RS23295	COG0477	Major facilitator Superfamily
K7395_RS23330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7395_RS23345	COG4555	ABC transporter
K7395_RS23360	COG2733	membrane
K7395_RS23370	COG2267	carboxylic ester hydrolase activity
K7395_RS23405	COG3655	Transcriptional regulator
K7395_RS23445	COG3764	Sortase (surface protein transpeptidase)
K7395_RS23455	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
K7395_RS23455	COG0706	membrane insertase activity
K7395_RS23465	COG4702	Belongs to the UPF0303 family
K7395_RS23470	COG0673	inositol 2-dehydrogenase activity
K7395_RS23475	COG1940	carbohydrate kinase activity
K7395_RS23485	COG2188	Transcriptional regulator
K7395_RS23490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7395_RS23570	COG3397	chitin binding
K7395_RS23575	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS23595	COG1126	abc transporter atp-binding protein
K7395_RS23600	COG0765	amino acid transport
K7395_RS23605	COG0765	amino acid transport
K7395_RS23610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS23630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7395_RS23705	COG0745	RESPONSE REGULATOR receiver
K7395_RS23720	COG2985	domain, Protein
K7395_RS23735	COG0395	ABC-type sugar transport system, permease component
K7395_RS23750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7395_RS23755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7395_RS23760	COG1595	DNA-templated transcription, initiation
K7395_RS23770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS23775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K7395_RS23800	COG3629	intracellular signal transduction
K7395_RS23800	COG3903	Transcriptional regulator
K7395_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS23810	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS23870	COG0519	Catalyzes the synthesis of GMP from XMP
K7395_RS23890	COG4977	sequence-specific DNA binding
K7395_RS23895	COG0589	response to stress
K7395_RS23900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7395_RS23925	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K7395_RS23930	COG0076	glutamate decarboxylase activity
K7395_RS23935	COG2375	cellular response to nickel ion
K7395_RS23950	COG1733	regulation of RNA biosynthetic process
K7395_RS23960	COG3537	Alpha-1,2-mannosidase
K7395_RS23990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K7395_RS23995	COG1960	acyl-CoA dehydrogenase activity
K7395_RS24010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7395_RS24015	COG1309	transcriptional regulator
K7395_RS24025	COG2311	Membrane
K7395_RS24050	COG1946	Acyl-CoA thioesterase
K7395_RS24055	COG1960	acyl-CoA dehydrogenase activity
K7395_RS24075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7395_RS24115	COG0515	serine threonine protein kinase
K7395_RS24115	COG2815	serine threonine protein kinase
K7395_RS24125	COG0657	acetylesterase activity
K7395_RS24185	COG1674	ftsk spoiiie
K7395_RS24215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7395_RS24225	COG0028	Belongs to the TPP enzyme family
K7395_RS24255	COG1472	Belongs to the glycosyl hydrolase 3 family
K7395_RS24260	COG0583	DNA-binding transcription factor activity
K7395_RS24280	COG1404	Belongs to the peptidase S8 family
K7395_RS24320	COG0515	serine threonine protein kinase
K7395_RS24345	COG1609	Transcriptional regulator
K7395_RS24350	COG0673	inositol 2-dehydrogenase activity
K7395_RS24365	COG2409	Drug exporters of the RND superfamily
K7395_RS24370	COG2318	DinB family
K7395_RS24430	COG0596	Alpha beta hydrolase
K7395_RS24445	COG3547	Transposase (IS116 IS110 IS902 family)
K7395_RS24455	COG2197	response regulator
K7395_RS24460	COG0477	Major facilitator Superfamily
K7395_RS24470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K7395_RS24495	COG2409	Drug exporters of the RND superfamily
K7395_RS24510	COG2318	DinB family
K7395_RS24520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS24530	COG3718	enzyme involved in inositol metabolism
K7395_RS24535	COG3962	Belongs to the TPP enzyme family
K7395_RS24550	COG4585	Histidine kinase
K7395_RS24555	COG2197	response regulator
K7395_RS24605	COG4585	Histidine kinase
K7395_RS24610	COG2197	response regulator
K7395_RS24665	COG3409	Peptidoglycan-binding domain 1 protein
K7395_RS24665	COG1388	LysM domain
K7395_RS24665	COG5632	N-Acetylmuramoyl-L-alanine amidase
K7395_RS24965	COG4974	Belongs to the 'phage' integrase family
K7395_RS24985	COG0629	single-stranded DNA binding
K7395_RS25010	COG1136	(ABC) transporter
K7395_RS25010	COG0577	efflux transmembrane transporter activity
K7395_RS25025	COG2346	COG2346, Truncated hemoglobins
K7395_RS25050	COG0515	serine threonine protein kinase
K7395_RS25060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS25075	COG1486	melibiose metabolic process
K7395_RS25080	COG0395	ABC-type sugar transport system, permease component
K7395_RS25085	COG1175	transmembrane transport
K7395_RS25095	COG1940	carbohydrate kinase activity
K7395_RS25100	COG0668	transmembrane transport
K7395_RS25110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K7395_RS25110	COG3291	Pkd domain containing protein
K7395_RS25135	COG4266	Belongs to the allantoicase family
K7395_RS25145	COG1132	(ABC) transporter
K7395_RS25170	COG2337	Toxic component of a toxin-antitoxin (TA) module
K7395_RS25195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K7395_RS25205	COG2252	PERMEase
K7395_RS25225	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS25260	COG0110	maltose O-acetyltransferase activity
K7395_RS25275	COG0640	Transcriptional regulator
K7395_RS25280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K7395_RS25285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K7395_RS25295	COG0584	glycerophosphoryl diester phosphodiesterase
K7395_RS25300	COG1113	amino acid transport
K7395_RS25305	COG1113	amino acid transport
K7395_RS25310	COG1268	BioY protein
K7395_RS25320	COG1113	amino acid transport
K7395_RS25340	COG0475	glutathione-regulated potassium exporter activity
K7395_RS25350	COG3594	Acyltransferase
K7395_RS25370	COG0544	peptidyl-prolyl cis-trans isomerase activity
K7395_RS25375	COG0740	serine-type endopeptidase activity
K7395_RS25380	COG0740	serine-type endopeptidase activity
K7395_RS25385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K7395_RS25395	COG0525	valine-tRNA ligase activity
K7395_RS25400	COG0285	dihydrofolate synthase activity
K7395_RS25410	COG0105	UTP biosynthetic process
K7395_RS25415	COG1077	Cell shape determining protein MreB Mrl
K7395_RS25430	COG0768	penicillin binding
K7395_RS25435	COG0772	Belongs to the SEDS family
K7395_RS25460	COG1530	ribonuclease E activity
K7395_RS25465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K7395_RS25470	COG0673	inositol 2-dehydrogenase activity
K7395_RS25475	COG0297	glycogen (starch) synthase activity
K7395_RS25495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K7395_RS25500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K7395_RS25505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K7395_RS25525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K7395_RS25530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K7395_RS25540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K7395_RS25555	COG0501	Belongs to the peptidase M48B family
K7395_RS25570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K7395_RS25580	COG0799	negative regulation of ribosome biogenesis
K7395_RS25585	COG0588	phosphoglycerate mutase activity
K7395_RS25595	COG1733	regulation of RNA biosynthetic process
K7395_RS25600	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS25610	COG2801	Transposase and inactivated derivatives
K7395_RS25610	COG3415	Transposase
K7395_RS25620	COG1733	regulation of RNA biosynthetic process
K7395_RS25650	COG0495	leucyl-tRNA aminoacylation
K7395_RS25660	COG1307	EDD domain protein, DegV family
K7395_RS25665	COG1555	photosystem II stabilization
K7395_RS25670	COG1234	tRNA 3'-trailer cleavage
K7395_RS25695	COG0268	Binds directly to 16S ribosomal RNA
K7395_RS25700	COG0481	GTPase activity
K7395_RS25705	COG1022	Amp-dependent synthetase and ligase
K7395_RS25745	COG1420	regulation of RNA biosynthetic process
K7395_RS25750	COG0484	heat shock protein binding
K7395_RS25765	COG0537	adenosine 5'-monophosphoramidase activity
K7395_RS25770	COG1234	tRNA 3'-trailer cleavage
K7395_RS25775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K7395_RS25785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS25795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K7395_RS25805	COG2315	Protein conserved in bacteria
K7395_RS25825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K7395_RS25840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7395_RS25850	COG1381	Involved in DNA repair and RecF pathway recombination
K7395_RS25855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7395_RS25865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K7395_RS25870	COG1121	(ABC) transporter
K7395_RS25880	COG0423	glycine-tRNA ligase activity
K7395_RS26015	COG0596	Alpha beta hydrolase
K7395_RS26030	COG1309	transcriptional regulator
K7395_RS26040	COG0574	Belongs to the PEP-utilizing enzyme family
K7395_RS26040	COG3848	Pyruvate phosphate dikinase
K7395_RS26050	COG2066	Belongs to the glutaminase family
K7395_RS26090	COG2188	Transcriptional regulator
K7395_RS26110	COG3842	ATPase activity
K7395_RS26120	COG0574	Belongs to the PEP-utilizing enzyme family
K7395_RS26120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7395_RS26140	COG2146	nitrite reductase [NAD(P)H] activity
K7395_RS26140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K7395_RS26145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K7395_RS26145	COG2146	nitrite reductase [NAD(P)H] activity
K7395_RS26190	COG2949	membrane
K7395_RS26200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K7395_RS26210	COG0358	DNA primase activity
K7395_RS26215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7395_RS26230	COG1070	Carbohydrate kinase
K7395_RS26260	COG0477	Major facilitator Superfamily
K7395_RS26265	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS26270	COG1309	transcriptional regulator
K7395_RS26275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K7395_RS26275	COG0825	malonyl-CoA metabolic process
K7395_RS26280	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS26300	COG1522	sequence-specific DNA binding
K7395_RS26330	COG2130	NADP-dependent
K7395_RS26335	COG1764	response to oxidative stress
K7395_RS26345	COG1280	lysine exporter protein (LysE YggA)
K7395_RS26365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7395_RS26370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7395_RS26375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7395_RS26390	COG1741	Belongs to the pirin family
K7395_RS26415	COG1929	Belongs to the glycerate kinase type-1 family
K7395_RS26425	COG0745	RESPONSE REGULATOR receiver
K7395_RS26430	COG2205	protein histidine kinase activity
K7395_RS26440	COG0789	Transcriptional regulator
K7395_RS26445	COG0667	Aldo Keto reductase
K7395_RS26465	COG3409	Peptidoglycan-binding domain 1 protein
K7395_RS26480	COG2197	response regulator
K7395_RS26485	COG4585	Histidine kinase
K7395_RS26500	COG1309	transcriptional regulator
K7395_RS26505	COG0477	Major facilitator Superfamily
K7395_RS26515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K7395_RS26560	COG1358	cellular component organization or biogenesis
K7395_RS26605	COG0483	inositol monophosphate 1-phosphatase activity
K7395_RS26645	COG2259	Doxx family
K7395_RS26695	COG2124	cytochrome p450
K7395_RS26700	COG0183	Belongs to the thiolase family
K7395_RS26710	COG3845	ABC transporter
K7395_RS26770	COG1131	(ABC) transporter
K7395_RS26865	COG1309	transcriptional regulator
K7395_RS26870	COG0438	transferase activity, transferring glycosyl groups
K7395_RS26900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7395_RS26925	COG1960	acyl-CoA dehydrogenase activity
K7395_RS26930	COG0183	Belongs to the thiolase family
K7395_RS26940	COG2030	dehydratase
K7395_RS26950	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS26960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K7395_RS26965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K7395_RS26985	COG0800	Aldolase
K7395_RS26990	COG3022	response to hydroperoxide
K7395_RS27020	COG2273	Hydrolase Family 16
K7395_RS27025	COG4948	Mandelate Racemase Muconate Lactonizing
K7395_RS27065	COG0384	phenazine biosynthesis protein PhzF
K7395_RS27075	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS27080	COG3540	Alkaline phosphatase
K7395_RS27090	COG2814	Major facilitator Superfamily
K7395_RS27105	COG1834	amidinotransferase
K7395_RS27125	COG1120	ATPase activity
K7395_RS27130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS27190	COG1994	Peptidase M50
K7395_RS27210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K7395_RS27215	COG0477	Major facilitator Superfamily
K7395_RS27230	COG2814	Major facilitator Superfamily
K7395_RS27235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7395_RS27235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K7395_RS27240	COG2132	Multicopper oxidase
K7395_RS27265	COG0174	glutamine synthetase
K7395_RS27280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7395_RS27300	COG0494	nUDIX hydrolase
K7395_RS27345	COG2814	Major facilitator Superfamily
K7395_RS27350	COG2890	protein-(glutamine-N5) methyltransferase activity
K7395_RS27360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K7395_RS27375	COG1609	Transcriptional regulator
K7395_RS27380	COG2182	Extracellular solute-binding protein
K7395_RS27390	COG0395	ABC-type sugar transport system, permease component
K7395_RS27395	COG0366	Alpha amylase catalytic
K7395_RS27465	COG2197	response regulator
K7395_RS27470	COG4585	Histidine kinase
K7395_RS27475	COG0745	RESPONSE REGULATOR receiver
K7395_RS27500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7395_RS27505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7395_RS27530	COG2362	D-Aminopeptidase
K7395_RS27535	COG1846	Transcriptional regulator
K7395_RS27545	COG3896	Chloramphenicol phosphotransferase-like protein
K7395_RS27550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7395_RS27590	COG0242	peptide deformylase activity
K7395_RS27615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K7395_RS27620	COG0321	lipoyl(octanoyl) transferase activity
K7395_RS27635	COG1090	epimerase
K7395_RS27655	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K7395_RS27670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7395_RS27675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7395_RS27680	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K7395_RS27695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K7395_RS27710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7395_RS27715	COG2226	methyltransferase
K7395_RS27735	COG4585	Histidine kinase
K7395_RS27740	COG2197	response regulator
K7395_RS27745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7395_RS27755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K7395_RS27775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS27785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7395_RS27790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7395_RS27800	COG1376	ErfK ybiS ycfS ynhG family protein
K7395_RS27810	COG1845	cytochrome c oxidase, subunit III
K7395_RS27815	COG2010	Cytochrome c
K7395_RS27820	COG0723	plastoquinol--plastocyanin reductase activity
K7395_RS27825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K7395_RS27830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K7395_RS27835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K7395_RS27880	COG0438	transferase activity, transferring glycosyl groups
K7395_RS27900	COG0003	Pfam Anion-transporting ATPase
K7395_RS27910	COG1940	carbohydrate kinase activity
K7395_RS27940	COG2197	response regulator
K7395_RS27945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7395_RS27955	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K7395_RS27965	COG2193	ferroxidase activity
K7395_RS27970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K7395_RS27975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K7395_RS27980	COG2815	serine threonine protein kinase
K7395_RS27980	COG0515	serine threonine protein kinase
K7395_RS27985	COG2022	thiamine diphosphate biosynthetic process
K7395_RS27995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7395_RS27995	COG2022	thiamine diphosphate biosynthetic process
K7395_RS28015	COG0352	thiamine-phosphate diphosphorylase activity
K7395_RS28030	COG1233	COG1233 Phytoene dehydrogenase and related
K7395_RS28050	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K7395_RS28060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K7395_RS28080	COG0714	Associated with various cellular activities
K7395_RS28090	COG0275	rRNA processing
K7395_RS28100	COG0768	penicillin binding
K7395_RS28105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K7395_RS28115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7395_RS28120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K7395_RS28130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K7395_RS28150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7395_RS28155	COG1799	cell septum assembly
K7395_RS28165	COG3599	regulation of cell shape
K7395_RS28170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K7395_RS28180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K7395_RS28230	COG0587	DNA-directed DNA polymerase activity
K7395_RS28240	COG1432	Conserved Protein
K7395_RS28280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K7395_RS28285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7395_RS28290	COG0131	Imidazoleglycerol-phosphate dehydratase
K7395_RS28300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K7395_RS28305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K7395_RS28310	COG0251	oxidation-reduction process
K7395_RS28315	COG0107	imidazoleglycerol-phosphate synthase activity
K7395_RS28330	COG2508	Transcriptional regulator
K7395_RS28350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K7395_RS28355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7395_RS28375	COG0134	indole-3-glycerol-phosphate synthase activity
K7395_RS28385	COG0133	tryptophan synthase activity
K7395_RS28390	COG0159	tryptophan synthase activity
K7395_RS28400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K7395_RS28405	COG2301	Belongs to the HpcH HpaI aldolase family
K7395_RS28410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K7395_RS28415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7395_RS28445	COG0067	glutamate synthase
K7395_RS28445	COG0070	glutamate synthase
K7395_RS28445	COG0069	glutamate synthase activity
K7395_RS28455	COG0705	Rhomboid family
K7395_RS28480	COG1960	acyl-CoA dehydrogenase activity
K7395_RS28485	COG1960	acyl-CoA dehydrogenase activity
K7395_RS28490	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS28495	COG1309	transcriptional regulator
K7395_RS28500	COG0183	Belongs to the thiolase family
K7395_RS28505	COG1278	Cold shock
K7395_RS28530	COG1024	Enoyl-CoA hydratase
K7395_RS28535	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS28575	COG1605	Chorismate mutase
K7395_RS28575	COG0287	Prephenate dehydrogenase
K7395_RS28595	COG2824	Alkylphosphonate utilization operon protein PhnA
K7395_RS28605	COG0659	secondary active sulfate transmembrane transporter activity
K7395_RS28625	COG0737	Belongs to the 5'-nucleotidase family
K7395_RS28680	COG2050	protein possibly involved in aromatic compounds catabolism
K7395_RS28715	COG1643	Atp-dependent helicase
K7395_RS28720	COG2226	methyltransferase
K7395_RS28740	COG0237	dephospho-CoA kinase activity
K7395_RS28755	COG2226	methyltransferase
K7395_RS28765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7395_RS28805	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K7395_RS28810	COG2313	pseudouridylate synthase activity
K7395_RS28820	COG0477	Major facilitator Superfamily
K7395_RS28835	COG0584	glycerophosphoryl diester phosphodiesterase
K7395_RS28845	COG0556	nucleotide-excision repair
K7395_RS28875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7395_RS28900	COG0322	excinuclease ABC activity
K7395_RS28905	COG1660	Displays ATPase and GTPase activities
K7395_RS28910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K7395_RS28915	COG1481	regulation of sporulation
K7395_RS28920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K7395_RS28925	COG0126	phosphoglycerate kinase activity
K7395_RS28930	COG0149	triose-phosphate isomerase activity
K7395_RS28935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K7395_RS28945	COG0166	Belongs to the GPI family
K7395_RS28970	COG0363	glucosamine-6-phosphate deaminase activity
K7395_RS28985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7395_RS28995	COG0109	protoheme IX farnesyltransferase activity
K7395_RS29035	COG0719	Fe-S assembly protein
K7395_RS29045	COG0396	ATPase activity
K7395_RS29050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K7395_RS29055	COG0822	iron-sulfur transferase activity
K7395_RS29060	COG2151	metal-sulfur cluster biosynthetic enzyme
K7395_RS29075	COG3226	Transcriptional regulator
K7395_RS29090	COG2171	N-acyltransferase activity
K7395_RS29095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7395_RS29105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K7395_RS29135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7395_RS29140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7395_RS29160	COG0768	penicillin binding
K7395_RS29170	COG4585	Histidine kinase
K7395_RS29185	COG1414	Transcriptional regulator
K7395_RS29215	COG1846	Transcriptional regulator
K7395_RS29220	COG1902	pentaerythritol trinitrate reductase activity
K7395_RS29250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K7395_RS29275	COG1797	cobyrinic acid a,c-diamide synthase activity
K7395_RS29290	COG1492	cobalamin metabolic process
K7395_RS29295	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K7395_RS29310	COG0235	Class ii aldolase
K7395_RS29335	COG0488	(ABC) transporter
K7395_RS29385	COG3387	PFAM Glycoside hydrolase 15-related
K7395_RS29400	COG1199	ATP-dependent helicase activity
K7395_RS29400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7395_RS29420	COG1404	Belongs to the peptidase S8 family
K7395_RS29430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7395_RS29435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7395_RS29450	COG2261	transglycosylase associated protein
K7395_RS29455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K7395_RS29470	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS29475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K7395_RS29485	COG2186	Transcriptional regulator
K7395_RS29510	COG0560	Phosphoserine phosphatase
K7395_RS29510	COG3830	Belongs to the UPF0237 family
K7395_RS29515	COG0842	Transport permease protein
K7395_RS29515	COG1131	(ABC) transporter
K7395_RS29515	COG1716	ATPase activity
K7395_RS29525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K7395_RS29540	COG2197	response regulator
K7395_RS29555	COG1119	ATPase activity
K7395_RS29565	COG3547	Transposase (IS116 IS110 IS902 family)
K7395_RS29585	COG1881	PFAM PEBP family protein
K7395_RS29595	COG2094	Belongs to the DNA glycosylase MPG family
K7395_RS29630	COG0647	UMP catabolic process
K7395_RS29635	COG1120	ATPase activity
K7395_RS29655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K7395_RS29660	COG0497	DNA recombination
K7395_RS29675	COG0789	Transcriptional regulator
K7395_RS29685	COG3387	PFAM Glycoside hydrolase 15-related
K7395_RS29690	COG0504	CTP synthase activity
K7395_RS29695	COG0494	nUDIX hydrolase
K7395_RS29705	COG0686	Belongs to the AlaDH PNT family
K7395_RS29720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K7395_RS29725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K7395_RS29730	COG1187	pseudouridine synthase activity
K7395_RS29745	COG0494	nUDIX hydrolase
K7395_RS29775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K7395_RS29785	COG1160	GTP binding
K7395_RS29800	COG0438	transferase activity, transferring glycosyl groups
K7395_RS29820	COG0671	phosphoesterase, PA-phosphatase related
K7395_RS29825	COG0477	Major facilitator Superfamily
K7395_RS29830	COG1960	acyl-CoA dehydrogenase activity
K7395_RS29835	COG1799	cell septum assembly
K7395_RS29845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS29850	COG0765	amino acid transport
K7395_RS29865	COG1126	abc transporter atp-binding protein
K7395_RS29870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7395_RS29875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7395_RS29880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7395_RS29910	COG0641	radical SAM
K7395_RS29955	COG4565	transcriptional regulatory protein
K7395_RS29975	COG0346	lactoylglutathione lyase activity
K7395_RS29990	COG1725	Transcriptional regulator
K7395_RS30000	COG2755	lipolytic protein G-D-S-L family
K7395_RS30010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K7395_RS30020	COG2188	Transcriptional regulator
K7395_RS30025	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K7395_RS30030	COG1309	transcriptional regulator
K7395_RS30035	COG0243	molybdopterin cofactor binding
K7395_RS30040	COG2851	Citrate transporter
K7395_RS30050	COG2318	DinB family
K7395_RS30065	COG2801	Transposase and inactivated derivatives
K7395_RS30065	COG3415	Transposase
K7395_RS30080	COG2326	polyphosphate kinase activity
K7395_RS30090	COG0640	Transcriptional regulator
K7395_RS30100	COG1960	acyl-CoA dehydrogenase activity
K7395_RS30120	COG0789	Transcriptional regulator
K7395_RS30135	COG3876	Protein conserved in bacteria
K7395_RS30145	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS30155	COG2234	aminopeptidase activity
K7395_RS30155	COG4935	Belongs to the peptidase S8 family
K7395_RS30160	COG1960	acyl-CoA dehydrogenase activity
K7395_RS30170	COG4948	Mandelate Racemase Muconate Lactonizing
K7395_RS30185	COG2149	membrane
K7395_RS30190	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K7395_RS30195	COG3573	Dehydrogenase
K7395_RS30220	COG3265	gluconokinase activity
K7395_RS30225	COG2186	Transcriptional regulator
K7395_RS30240	COG0564	pseudouridine synthase activity
K7395_RS30250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7395_RS30280	COG0667	Aldo Keto reductase
K7395_RS30285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7395_RS30295	COG0598	Magnesium transport protein CorA
K7395_RS30315	COG0215	cysteine-tRNA ligase activity
K7395_RS30335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K7395_RS30340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K7395_RS30345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K7395_RS30350	COG1414	Transcriptional regulator
K7395_RS30355	COG0646	methionine synthase
K7395_RS30355	COG1410	methionine synthase
K7395_RS30360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS30365	COG4166	transmembrane transport
K7395_RS30370	COG2197	response regulator
K7395_RS30380	COG0517	IMP dehydrogenase activity
K7395_RS30380	COG1994	Peptidase M50
K7395_RS30400	COG1222	aaa ATPase
K7395_RS30405	COG4122	O-methyltransferase activity
K7395_RS30420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K7395_RS30425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K7395_RS30430	COG1609	Transcriptional regulator
K7395_RS30440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K7395_RS30445	COG0545	Peptidyl-prolyl cis-trans isomerase
K7395_RS30455	COG2378	regulation of single-species biofilm formation
K7395_RS30475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7395_RS30480	COG0805	protein transport
K7395_RS30515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7395_RS30520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7395_RS30565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7395_RS30570	COG0517	IMP dehydrogenase activity
K7395_RS30570	COG4175	Glycine betaine
K7395_RS30615	COG1404	Belongs to the peptidase S8 family
K7395_RS30625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K7395_RS30635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K7395_RS30640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K7395_RS30645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K7395_RS30650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7395_RS30655	COG5002	protein histidine kinase activity
K7395_RS30660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K7395_RS30665	COG0072	phenylalanine-tRNA ligase activity
K7395_RS30665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7395_RS30685	COG1649	PFAM Uncharacterised BCR, COG1649
K7395_RS30695	COG0697	spore germination
K7395_RS30785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7395_RS30790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K7395_RS30795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K7395_RS30800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K7395_RS30805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7395_RS30810	COG1438	arginine binding
K7395_RS30825	COG0137	argininosuccinate synthase activity
K7395_RS30830	COG0165	Argininosuccinate lyase
K7395_RS30840	COG3973	AAA domain
K7395_RS30850	COG0477	Major facilitator Superfamily
K7395_RS30890	COG2011	ABC-type metal ion transport system permease component
K7395_RS30895	COG1464	Belongs to the NlpA lipoprotein family
K7395_RS30910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K7395_RS30915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K7395_RS30915	COG1648	precorrin-2 dehydrogenase activity
K7395_RS30970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7395_RS30980	COG0454	-acetyltransferase
K7395_RS30980	COG0456	acetyltransferase
K7395_RS31030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7395_RS31045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K7395_RS31070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7395_RS31075	COG1560	Kdo2-lipid A biosynthetic process
K7395_RS31080	COG0438	transferase activity, transferring glycosyl groups
K7395_RS31090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K7395_RS31095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K7395_RS31100	COG0217	transcriptional regulatory protein
K7395_RS31110	COG0632	four-way junction helicase activity
K7395_RS31115	COG2255	four-way junction helicase activity
K7395_RS31125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7395_RS31130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7395_RS31135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K7395_RS31140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7395_RS31145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7395_RS31155	COG1196	nuclear chromosome segregation
K7395_RS31170	COG0124	histidyl-tRNA synthetase
K7395_RS31175	COG2197	response regulator
K7395_RS31180	COG4585	Histidine kinase
K7395_RS31190	COG1131	(ABC) transporter
K7395_RS31210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K7395_RS31230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7395_RS31235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K7395_RS31245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K7395_RS31250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K7395_RS31255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K7395_RS31260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7395_RS31270	COG0006	proline dipeptidase activity
K7395_RS31275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7395_RS31280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7395_RS31290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K7395_RS31295	COG0540	Belongs to the ATCase OTCase family
K7395_RS31300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7395_RS31310	COG0505	Belongs to the CarA family
K7395_RS31315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K7395_RS31320	COG0167	dihydroorotate dehydrogenase activity
K7395_RS31325	COG0284	orotidine-5'-phosphate decarboxylase activity
K7395_RS31340	COG1758	RNA polymerase activity
K7395_RS31350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K7395_RS31355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K7395_RS31365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K7395_RS31375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K7395_RS31380	COG2390	Transcriptional regulator
K7395_RS31395	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS31405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7395_RS31425	COG2233	PERMEase
K7395_RS31430	COG0738	Major facilitator superfamily
K7395_RS31440	COG0702	epimerase
K7395_RS31460	COG3201	nicotinamide mononucleotide transporter
K7395_RS31465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7395_RS31465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7395_RS31470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K7395_RS31475	COG0140	phosphoribosyl-ATP diphosphatase activity
K7395_RS31480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K7395_RS31535	COG2318	DinB family
K7395_RS31545	COG3415	Transposase
K7395_RS31545	COG2801	Transposase and inactivated derivatives
K7395_RS31555	COG1960	acyl-CoA dehydrogenase activity
K7395_RS31575	COG1216	Glycosyl transferase, family 2
K7395_RS31590	COG2270	Major facilitator Superfamily
K7395_RS31600	COG2364	Membrane
K7395_RS31665	COG2018	Roadblock/LC7 domain
K7395_RS31680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7395_RS31695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K7395_RS31710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7395_RS31720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7395_RS31750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K7395_RS31770	COG1716	ATPase activity
K7395_RS31790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7395_RS31800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7395_RS31800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7395_RS31865	COG1695	Transcriptional regulator
K7395_RS31905	COG0697	spore germination
K7395_RS31910	COG0583	DNA-binding transcription factor activity
K7395_RS31940	COG3547	Transposase (IS116 IS110 IS902 family)
K7395_RS31950	COG0789	Transcriptional regulator
K7395_RS31960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7395_RS31965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7395_RS31980	COG0546	phosphoglycolate phosphatase activity
K7395_RS31990	COG0604	alcohol dehydrogenase
K7395_RS31990	COG3321	synthase
K7395_RS31995	COG0604	alcohol dehydrogenase
K7395_RS31995	COG3321	synthase
K7395_RS32010	COG0604	alcohol dehydrogenase
K7395_RS32010	COG3321	synthase
K7395_RS32015	COG3321	synthase
K7395_RS32015	COG0604	alcohol dehydrogenase
K7395_RS32020	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K7395_RS32045	COG0022	dehydrogenase e1 component
K7395_RS32050	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7395_RS32060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7395_RS32080	COG0778	Nitroreductase
K7395_RS32085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K7395_RS32110	COG0151	Belongs to the GarS family
K7395_RS32115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K7395_RS32125	COG0602	queuosine metabolic process
K7395_RS32130	COG0302	gtp cyclohydrolase
K7395_RS32140	COG2175	clavaminate synthase activity
K7395_RS32175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K7395_RS32190	COG2318	DinB family
K7395_RS32240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7395_RS32245	COG4106	trans-aconitate 2-methyltransferase activity
K7395_RS32250	COG0243	molybdopterin cofactor binding
K7395_RS32285	COG1968	undecaprenyl-diphosphatase activity
K7395_RS32305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7395_RS32350	COG1832	CoA-binding protein
K7395_RS32355	COG1739	Uncharacterized protein family UPF0029
K7395_RS32360	COG0420	3'-5' exonuclease activity
K7395_RS32365	COG0419	ATPase involved in DNA repair
K7395_RS32370	COG1522	sequence-specific DNA binding
K7395_RS32395	COG0626	cystathionine gamma-synthase activity
K7395_RS32420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7395_RS32435	COG1595	DNA-templated transcription, initiation
K7395_RS32440	COG2188	Transcriptional regulator
K7395_RS32445	COG1940	carbohydrate kinase activity
K7395_RS32450	COG2197	response regulator
K7395_RS32455	COG4585	Histidine kinase
K7395_RS32455	COG2203	Gaf domain
K7395_RS32475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K7395_RS32500	COG2226	methyltransferase
K7395_RS32505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K7395_RS32510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7395_RS32515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K7395_RS32520	COG0156	8-amino-7-oxononanoate synthase activity
K7395_RS32540	COG0583	DNA-binding transcription factor activity
K7395_RS32545	COG1280	lysine exporter protein (LysE YggA)
K7395_RS32560	COG0740	serine-type endopeptidase activity
K7395_RS32575	COG1309	transcriptional regulator
K7395_RS32580	COG0831	urea catabolic process
K7395_RS32585	COG0832	Belongs to the urease beta subunit family
K7395_RS32590	COG0804	urea catabolic process
K7395_RS32600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K7395_RS32605	COG0829	nickel cation binding
K7395_RS32625	COG0204	Acyl-transferase
K7395_RS32640	COG0205	6-phosphofructokinase activity
K7395_RS32645	COG3442	glutamine amidotransferase
K7395_RS32655	COG0242	peptide deformylase activity
K7395_RS32665	COG1960	acyl-CoA dehydrogenase activity
K7395_RS32670	COG0386	Belongs to the glutathione peroxidase family
K7395_RS32705	COG1946	Acyl-CoA thioesterase
K7395_RS32720	COG1793	dna ligase
K7395_RS32725	COG1252	NADH dehydrogenase
K7395_RS32740	COG1132	(ABC) transporter
K7395_RS32755	COG0277	FAD linked oxidase domain protein
K7395_RS32760	COG1846	Transcriptional regulator
K7395_RS32765	COG1132	(ABC) transporter
K7395_RS32775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K7395_RS32810	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K7395_RS32815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS32830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7395_RS32845	COG1120	ATPase activity
K7395_RS32850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K7395_RS32860	COG0803	Belongs to the bacterial solute-binding protein 9 family
K7395_RS32885	COG0318	PFAM AMP-dependent synthetase and ligase
K7395_RS32910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7395_RS32915	COG3251	PFAM MbtH domain protein
K7395_RS32930	COG3483	tryptophan 2,3-dioxygenase activity
K7395_RS32945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7395_RS32955	COG2197	response regulator
K7395_RS32960	COG1609	Transcriptional regulator
K7395_RS32970	COG1175	transmembrane transport
K7395_RS32975	COG0395	ABC-type sugar transport system, permease component
K7395_RS33010	COG0464	growth
K7395_RS33020	COG1674	ftsk spoiiie
K7395_RS33040	COG4842	Belongs to the WXG100 family
K7395_RS33075	COG1309	transcriptional regulator
K7395_RS33080	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS33090	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7395_RS33090	COG1902	pentaerythritol trinitrate reductase activity
K7395_RS33115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7395_RS33135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K7395_RS33160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K7395_RS33175	COG1891	lyase activity
K7395_RS33185	COG2160	L-arabinose isomerase activity
K7395_RS33195	COG1609	Transcriptional regulator
K7395_RS33205	COG1129	ABC transporter
K7395_RS33210	COG4214	carbohydrate transport
K7395_RS33250	COG4592	Periplasmic binding protein
K7395_RS33260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS33265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7395_RS33285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K7395_RS33310	COG1174	glycine betaine transport
K7395_RS33315	COG1174	glycine betaine transport
K7395_RS33335	COG2080	2 iron, 2 sulfur cluster binding
K7395_RS33340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K7395_RS33345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K7395_RS33355	COG1309	transcriptional regulator
K7395_RS33375	COG2890	protein-(glutamine-N5) methyltransferase activity
K7395_RS33390	COG1335	isochorismatase
K7395_RS33440	COG1982	Orn Lys Arg decarboxylase major
K7395_RS33445	COG1028	Short-chain dehydrogenase reductase Sdr
K7395_RS33465	COG0542	response to heat
K7395_RS33475	COG0583	DNA-binding transcription factor activity
K7395_RS33480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K7395_RS33490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7395_RS33495	COG0303	'Molybdopterin
K7395_RS33525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7395_RS33525	COG0515	serine threonine protein kinase
K7395_RS33545	COG0402	S-adenosylhomocysteine deaminase activity
K7395_RS33550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K7395_RS33565	COG2835	tetraacyldisaccharide 4'-kinase activity
K7395_RS33585	COG4981	capsule polysaccharide biosynthetic process
K7395_RS33620	COG1012	belongs to the aldehyde dehydrogenase family
K7395_RS33625	COG0174	glutamine synthetase
K7395_RS33635	COG0531	amino acid
K7395_RS33640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K7395_RS33675	COG1253	flavin adenine dinucleotide binding
K7395_RS33720	COG0667	Aldo Keto reductase
K7395_RS33725	COG0515	serine threonine protein kinase
K7395_RS33725	COG2815	serine threonine protein kinase
K7395_RS33750	COG2706	6-phosphogluconolactonase activity
K7395_RS33765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K7395_RS33815	COG0671	phosphoesterase, PA-phosphatase related
K7395_RS33835	COG0584	glycerophosphoryl diester phosphodiesterase
K7395_RS33880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K7395_RS33910	COG1940	carbohydrate kinase activity
K7395_RS33920	COG1660	Displays ATPase and GTPase activities
K7395_RS33935	COG0445	tRNA wobble uridine modification
K7395_RS33950	COG4585	Histidine kinase
K7395_RS33955	COG2197	response regulator
K7395_RS33965	COG2223	nitrite transmembrane transporter activity
K7395_RS33970	COG1940	carbohydrate kinase activity
K7395_RS34010	COG0702	epimerase
K7395_RS34025	COG1349	DNA-binding transcription factor activity
K7395_RS34035	COG0464	growth
K7395_RS34070	COG5002	protein histidine kinase activity
K7395_RS34070	COG5000	phosphorelay sensor kinase activity
K7395_RS34130	COG3275	phosphorelay sensor kinase activity
K7395_RS34205	COG0583	DNA-binding transcription factor activity
K7395_RS34215	COG1053	succinate dehydrogenase
K7395_RS34220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family