locus-tag	class	description
F0344_RS00020	COG0539	negative regulation of cytoplasmic translation
F0344_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS00105	COG2208	phosphoserine phosphatase activity
F0344_RS00105	COG2770	Histidine kinase
F0344_RS00170	COG0596	Alpha beta hydrolase
F0344_RS00365	COG3384	dioxygenase
F0344_RS00385	COG1064	alcohol dehydrogenase
F0344_RS00390	COG1309	transcriptional regulator
F0344_RS00410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F0344_RS00425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0344_RS00445	COG0425	Belongs to the sulfur carrier protein TusA family
F0344_RS00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0344_RS00505	COG3507	Belongs to the glycosyl hydrolase 43 family
F0344_RS00530	COG2814	Major facilitator Superfamily
F0344_RS00565	COG0789	Transcriptional regulator
F0344_RS00595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0344_RS00600	COG3973	AAA domain
F0344_RS00600	COG3973	AAA domain
F0344_RS00605	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0344_RS00660	COG2318	DinB family
F0344_RS00700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0344_RS00710	COG1357	PFAM Pentapeptide repeats (8 copies)
F0344_RS00725	COG0640	Transcriptional regulator
F0344_RS00735	COG1024	Enoyl-CoA hydratase
F0344_RS00750	COG2018	Roadblock/LC7 domain
F0344_RS00795	COG3239	Fatty acid desaturase
F0344_RS00800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0344_RS00810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0344_RS00825	COG2239	Acts as a magnesium transporter
F0344_RS00870	COG0516	GMP reductase activity
F0344_RS00870	COG0517	IMP dehydrogenase activity
F0344_RS00885	COG0589	response to stress
F0344_RS00900	COG0589	response to stress
F0344_RS00910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0344_RS00915	COG0569	domain protein
F0344_RS00930	COG0589	response to stress
F0344_RS00935	COG0517	IMP dehydrogenase activity
F0344_RS00935	COG0516	GMP reductase activity
F0344_RS00945	COG1063	alcohol dehydrogenase
F0344_RS00955	COG0589	response to stress
F0344_RS00970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0344_RS00970	COG1017	nitric oxide dioxygenase activity
F0344_RS00980	COG1288	antiporter activity
F0344_RS00985	COG0549	Belongs to the carbamate kinase family
F0344_RS00990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0344_RS00995	COG2235	arginine
F0344_RS01025	COG0574	Belongs to the PEP-utilizing enzyme family
F0344_RS01025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0344_RS01050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F0344_RS01050	COG0617	tRNA 3'-terminal CCA addition
F0344_RS01050	COG0517	IMP dehydrogenase activity
F0344_RS01070	COG0783	Belongs to the Dps family
F0344_RS01075	COG0142	geranyltranstransferase activity
F0344_RS01095	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F0344_RS01100	COG2226	methyltransferase
F0344_RS01120	COG1595	DNA-templated transcription, initiation
F0344_RS01170	COG1126	abc transporter atp-binding protein
F0344_RS01185	COG1737	Transcriptional regulator
F0344_RS01200	COG0596	Alpha beta hydrolase
F0344_RS01235	COG5002	protein histidine kinase activity
F0344_RS01240	COG0745	RESPONSE REGULATOR receiver
F0344_RS01260	COG0640	Transcriptional regulator
F0344_RS01305	COG3896	Chloramphenicol phosphotransferase-like protein
F0344_RS01330	COG2356	endonuclease I
F0344_RS01340	COG0463	Glycosyl transferase, family 2
F0344_RS01360	COG1505	serine-type exopeptidase activity
F0344_RS01455	COG0009	L-threonylcarbamoyladenylate synthase
F0344_RS01460	COG2267	carboxylic ester hydrolase activity
F0344_RS01515	COG0444	Belongs to the ABC transporter superfamily
F0344_RS01520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0344_RS01525	COG0601	transmembrane transport
F0344_RS01535	COG1960	acyl-CoA dehydrogenase activity
F0344_RS01540	COG1960	acyl-CoA dehydrogenase activity
F0344_RS01560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0344_RS01575	COG3458	cephalosporin-C deacetylase activity
F0344_RS01595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0344_RS01605	COG4585	Histidine kinase
F0344_RS01610	COG2409	Drug exporters of the RND superfamily
F0344_RS01640	COG1295	ribonuclease BN
F0344_RS01730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0344_RS01735	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F0344_RS01740	COG1793	dna ligase
F0344_RS01785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0344_RS01795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0344_RS01800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F0344_RS01865	COG2801	Transposase and inactivated derivatives
F0344_RS01950	COG0254	rRNA binding
F0344_RS01960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0344_RS01970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0344_RS01975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0344_RS01990	COG1609	Transcriptional regulator
F0344_RS01995	COG3858	chitin binding
F0344_RS02010	COG3572	ergothioneine biosynthetic process
F0344_RS02015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0344_RS02020	COG0121	glutamine amidotransferase
F0344_RS02025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F0344_RS02045	COG2182	Extracellular solute-binding protein
F0344_RS02050	COG3360	Dodecin
F0344_RS02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0344_RS02070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0344_RS02075	COG1053	succinate dehydrogenase
F0344_RS02150	COG3275	phosphorelay sensor kinase activity
F0344_RS02155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0344_RS02170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0344_RS02190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS02230	COG1191	sigma factor activity
F0344_RS02250	COG1652	LysM domain
F0344_RS02260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0344_RS02275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0344_RS02295	COG0019	diaminopimelate decarboxylase activity
F0344_RS02315	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F0344_RS02385	COG1902	pentaerythritol trinitrate reductase activity
F0344_RS02385	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0344_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS02455	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F0344_RS02455	COG1672	PFAM Archaeal ATPase
F0344_RS02515	COG1556	Lactate utilization protein
F0344_RS02520	COG1139	Iron-sulfur cluster binding protein
F0344_RS02525	COG0247	lactate metabolic process
F0344_RS02550	COG3959	Transketolase, thiamine diphosphate binding domain
F0344_RS02555	COG3958	Transketolase
F0344_RS02595	COG3467	pyridoxamine 5'-phosphate
F0344_RS02600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0344_RS02635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0344_RS02645	COG2755	lipolytic protein G-D-S-L family
F0344_RS02655	COG2365	Tyrosine phosphatase family
F0344_RS02675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0344_RS02690	COG1657	PFAM Prenyltransferase squalene oxidase
F0344_RS02700	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F0344_RS02710	COG1562	ergosterol biosynthetic process
F0344_RS02715	COG1134	teichoic acid transport
F0344_RS02760	COG2226	methyltransferase
F0344_RS02765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0344_RS02780	COG1024	Enoyl-CoA hydratase
F0344_RS02790	COG4977	sequence-specific DNA binding
F0344_RS02800	COG2183	response to ionizing radiation
F0344_RS02805	COG0488	(ABC) transporter
F0344_RS02815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0344_RS02840	COG0789	Transcriptional regulator
F0344_RS02845	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0344_RS02845	COG1024	Enoyl-CoA hydratase
F0344_RS02850	COG0183	Belongs to the thiolase family
F0344_RS02860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0344_RS02865	COG3268	Saccharopine dehydrogenase
F0344_RS02875	COG1515	deoxyribonuclease V activity
F0344_RS02895	COG1834	amidinotransferase
F0344_RS02920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0344_RS02945	COG1793	dna ligase
F0344_RS03005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0344_RS03060	COG3012	SEC-C Motif Domain Protein
F0344_RS03105	COG1486	melibiose metabolic process
F0344_RS03140	COG1846	Transcriptional regulator
F0344_RS03170	COG1940	carbohydrate kinase activity
F0344_RS03180	COG2115	Belongs to the xylose isomerase family
F0344_RS03185	COG1070	Carbohydrate kinase
F0344_RS03210	COG4176	ABC-type proline glycine betaine transport system permease component
F0344_RS03215	COG0517	IMP dehydrogenase activity
F0344_RS03215	COG4175	Glycine betaine
F0344_RS03225	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS03230	COG1501	Belongs to the glycosyl hydrolase 31 family
F0344_RS03235	COG1472	Belongs to the glycosyl hydrolase 3 family
F0344_RS03245	COG4209	transmembrane transport
F0344_RS03250	COG0395	ABC-type sugar transport system, permease component
F0344_RS03325	COG2197	response regulator
F0344_RS03380	COG1869	D-ribose catabolic process
F0344_RS03385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0344_RS03395	COG1129	ABC transporter
F0344_RS03400	COG1609	Transcriptional regulator
F0344_RS03420	COG0515	serine threonine protein kinase
F0344_RS03420	COG2815	serine threonine protein kinase
F0344_RS03430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0344_RS03480	COG1401	restriction endodeoxyribonuclease activity
F0344_RS03490	COG0210	DNA helicase
F0344_RS03535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F0344_RS03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0344_RS03570	COG1129	ABC transporter
F0344_RS03575	COG1940	carbohydrate kinase activity
F0344_RS03585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0344_RS03605	COG0656	L-ascorbic acid biosynthetic process
F0344_RS03620	COG2890	protein-(glutamine-N5) methyltransferase activity
F0344_RS03645	COG2154	pterin-4-alpha-carbinolamine dehydratase
F0344_RS03650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0344_RS03650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0344_RS03695	COG3386	PFAM SMP-30 Gluconolaconase
F0344_RS03700	COG1414	Transcriptional regulator
F0344_RS03710	COG4106	trans-aconitate 2-methyltransferase activity
F0344_RS03720	COG1660	Displays ATPase and GTPase activities
F0344_RS03725	COG0457	Tetratricopeptide repeat
F0344_RS03730	COG1280	lysine exporter protein (LysE YggA)
F0344_RS03755	COG1619	proteins homologs of microcin C7 resistance protein MccF
F0344_RS03765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0344_RS03770	COG2362	D-Aminopeptidase
F0344_RS03795	COG3290	protein histidine kinase activity
F0344_RS03800	COG0598	Magnesium transport protein CorA
F0344_RS03805	COG0667	Aldo Keto reductase
F0344_RS03810	COG0583	DNA-binding transcription factor activity
F0344_RS03835	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0344_RS03855	COG0604	alcohol dehydrogenase
F0344_RS03860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS03860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS03865	COG2301	Belongs to the HpcH HpaI aldolase family
F0344_RS03875	COG1960	acyl-CoA dehydrogenase activity
F0344_RS03880	COG0688	phosphatidylethanolamine metabolic process
F0344_RS03900	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0344_RS03920	COG1929	Belongs to the glycerate kinase type-1 family
F0344_RS03965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0344_RS03985	COG0483	inositol monophosphate 1-phosphatase activity
F0344_RS04005	COG0640	Transcriptional regulator
F0344_RS04020	COG2838	Isocitrate dehydrogenase
F0344_RS04025	COG2197	response regulator
F0344_RS04040	COG4106	trans-aconitate 2-methyltransferase activity
F0344_RS04040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0344_RS04050	COG1953	Uracil, thiamine, allantoin
F0344_RS04060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0344_RS04080	COG0667	Aldo Keto reductase
F0344_RS04115	COG0405	Gamma-glutamyltransferase
F0344_RS04120	COG2409	Drug exporters of the RND superfamily
F0344_RS04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0344_RS04130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0344_RS04135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0344_RS04150	COG1937	Protein conserved in bacteria
F0344_RS04155	COG0765	amino acid transport
F0344_RS04160	COG0765	amino acid transport
F0344_RS04165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0344_RS04170	COG1126	abc transporter atp-binding protein
F0344_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS04195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0344_RS04200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F0344_RS04250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0344_RS04255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F0344_RS04260	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0344_RS04260	COG0022	dehydrogenase e1 component
F0344_RS04265	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0344_RS04280	COG1940	carbohydrate kinase activity
F0344_RS04285	COG1129	ABC transporter
F0344_RS04305	COG2188	Transcriptional regulator
F0344_RS04310	COG0673	inositol 2-dehydrogenase activity
F0344_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS04345	COG4266	Belongs to the allantoicase family
F0344_RS04350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0344_RS04355	COG1414	Transcriptional regulator
F0344_RS04370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0344_RS04405	COG2233	PERMEase
F0344_RS04420	COG2351	hydroxyisourate hydrolase activity
F0344_RS04465	COG3622	Belongs to the hyi family
F0344_RS04470	COG2084	Dehydrogenase
F0344_RS04475	COG0753	catalase activity
F0344_RS04480	COG3960	tartronate-semialdehyde synthase activity
F0344_RS04505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0344_RS04510	COG2197	response regulator
F0344_RS04525	COG0435	Glutathione S-transferase
F0344_RS04545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0344_RS04565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F0344_RS04565	COG3608	succinylglutamate desuccinylase aspartoacylase
F0344_RS04570	COG2252	PERMEase
F0344_RS04575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0344_RS04590	COG3835	regulator
F0344_RS04625	COG3291	Pkd domain containing protein
F0344_RS04630	COG1802	Transcriptional regulator
F0344_RS04635	COG0028	Belongs to the TPP enzyme family
F0344_RS04830	COG0270	DNA (cytosine-5-)-methyltransferase activity
F0344_RS04905	COG1162	GTPase activity
F0344_RS04950	COG0183	Belongs to the thiolase family
F0344_RS04955	COG0583	DNA-binding transcription factor activity
F0344_RS04960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F0344_RS04965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F0344_RS04970	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0344_RS04990	COG1960	acyl-CoA dehydrogenase activity
F0344_RS05000	COG4991	sh3 domain protein
F0344_RS05020	COG0175	sulfate reduction
F0344_RS05025	COG0529	Catalyzes the synthesis of activated sulfate
F0344_RS05050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0344_RS05060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F0344_RS05180	COG0583	DNA-binding transcription factor activity
F0344_RS05190	COG1063	alcohol dehydrogenase
F0344_RS05255	COG2226	methyltransferase
F0344_RS05260	COG3226	Transcriptional regulator
F0344_RS05375	COG1222	aaa ATPase
F0344_RS05410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0344_RS05415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0344_RS05470	COG3220	belongs to the UPF0276 family
F0344_RS05490	COG3253	May function as heme-dependent peroxidase
F0344_RS05495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F0344_RS05505	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0344_RS05515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0344_RS05530	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F0344_RS05535	COG0183	Belongs to the thiolase family
F0344_RS05540	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0344_RS05540	COG1024	Enoyl-CoA hydratase
F0344_RS05550	COG1316	TRANSCRIPTIONal
F0344_RS05560	COG0531	amino acid
F0344_RS05565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0344_RS05570	COG4214	carbohydrate transport
F0344_RS05580	COG4213	ABC transporter substrate-binding protein
F0344_RS05585	COG1940	carbohydrate kinase activity
F0344_RS05590	COG0395	ABC-type sugar transport system, permease component
F0344_RS05595	COG1175	transmembrane transport
F0344_RS05600	COG1653	transport
F0344_RS05630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F0344_RS05655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0344_RS05705	COG2197	response regulator
F0344_RS05725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0344_RS05730	COG0402	S-adenosylhomocysteine deaminase activity
F0344_RS05750	COG0596	Alpha beta hydrolase
F0344_RS05755	COG0667	Aldo Keto reductase
F0344_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS05855	COG2208	phosphoserine phosphatase activity
F0344_RS05855	COG2770	Histidine kinase
F0344_RS05860	COG0596	Alpha beta hydrolase
F0344_RS05905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F0344_RS05920	COG0583	DNA-binding transcription factor activity
F0344_RS05935	COG1278	Cold shock
F0344_RS05945	COG0297	glycogen (starch) synthase activity
F0344_RS05945	COG0438	transferase activity, transferring glycosyl groups
F0344_RS05950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0344_RS05960	COG0728	peptidoglycan biosynthetic process
F0344_RS05970	COG0438	transferase activity, transferring glycosyl groups
F0344_RS05990	COG2304	oxidoreductase activity
F0344_RS06010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0344_RS06015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0344_RS06020	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F0344_RS06045	COG0438	transferase activity, transferring glycosyl groups
F0344_RS06060	COG0489	protein tyrosine kinase activity
F0344_RS06065	COG0297	glycogen (starch) synthase activity
F0344_RS06080	COG1320	monovalent cation:proton antiporter activity
F0344_RS06095	COG0651	ATP synthesis coupled electron transport
F0344_RS06100	COG1006	Multisubunit Na H antiporter MnhC subunit
F0344_RS06105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0344_RS06105	COG2111	Na H antiporter
F0344_RS06110	COG3592	Divergent 4Fe-4S mono-cluster
F0344_RS06145	COG1024	Enoyl-CoA hydratase
F0344_RS06155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0344_RS06165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0344_RS06175	COG2040	homocysteine
F0344_RS06195	COG1799	cell septum assembly
F0344_RS06200	COG1349	DNA-binding transcription factor activity
F0344_RS06215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0344_RS06220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0344_RS06230	COG0765	amino acid transport
F0344_RS06235	COG0765	amino acid transport
F0344_RS06240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0344_RS06245	COG1126	abc transporter atp-binding protein
F0344_RS06250	COG4977	sequence-specific DNA binding
F0344_RS06270	COG1132	(ABC) transporter
F0344_RS06275	COG1132	(ABC) transporter
F0344_RS06300	COG1120	ATPase activity
F0344_RS06305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0344_RS06310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0344_RS06325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0344_RS06330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0344_RS06340	COG1472	Belongs to the glycosyl hydrolase 3 family
F0344_RS06345	COG0395	ABC-type sugar transport system, permease component
F0344_RS06350	COG1175	transmembrane transport
F0344_RS06360	COG1609	Transcriptional regulator
F0344_RS06385	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS06395	COG4651	solute:proton antiporter activity
F0344_RS06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0344_RS06435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0344_RS06470	COG1140	nitrate reductase beta subunit
F0344_RS06520	COG1140	nitrate reductase beta subunit
F0344_RS06540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0344_RS06540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0344_RS06555	COG1937	Protein conserved in bacteria
F0344_RS06560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0344_RS06580	COG1834	amidinotransferase
F0344_RS06585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0344_RS06605	COG1136	(ABC) transporter
F0344_RS06615	COG1074	ATP-dependent DNA helicase activity
F0344_RS06650	COG0515	serine threonine protein kinase
F0344_RS06650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0344_RS06655	COG3693	PFAM glycoside hydrolase, family 10
F0344_RS06670	COG0477	Major facilitator Superfamily
F0344_RS06695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0344_RS06715	COG2319	Wd-40 repeat
F0344_RS06715	COG4249	Peptidase C14 caspase catalytic subunit p20
F0344_RS06725	COG0500	methyltransferase
F0344_RS06735	COG2409	Drug exporters of the RND superfamily
F0344_RS06755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0344_RS06760	COG0531	amino acid
F0344_RS06770	COG1802	Transcriptional regulator
F0344_RS06775	COG0569	domain protein
F0344_RS06805	COG1136	(ABC) transporter
F0344_RS06805	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0344_RS06815	COG0756	dUTP diphosphatase activity
F0344_RS06840	COG2205	protein histidine kinase activity
F0344_RS06845	COG0745	RESPONSE REGULATOR receiver
F0344_RS06855	COG0483	inositol monophosphate 1-phosphatase activity
F0344_RS06860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0344_RS06905	COG1435	thymidine kinase activity
F0344_RS06920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0344_RS06920	COG0045	succinate-CoA ligase (ADP-forming) activity
F0344_RS06920	COG1042	CoA-binding domain protein
F0344_RS06925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0344_RS06930	COG1802	Transcriptional regulator
F0344_RS06945	COG0612	Peptidase, M16
F0344_RS06950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0344_RS06975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0344_RS06985	COG0187	DNA topoisomerase II activity
F0344_RS07000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0344_RS07005	COG2186	Transcriptional regulator
F0344_RS07010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0344_RS07030	COG1278	Cold shock
F0344_RS07055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0344_RS07095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0344_RS07100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0344_RS07105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0344_RS07120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0344_RS07140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0344_RS07150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0344_RS07155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0344_RS07200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0344_RS07210	COG1205	dead DEAH box helicase
F0344_RS07210	COG1111	helicase
F0344_RS07215	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F0344_RS07290	COG0252	asparaginase activity
F0344_RS07330	COG0667	Aldo Keto reductase
F0344_RS07360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS07365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0344_RS07395	COG3845	ABC transporter
F0344_RS07435	COG3344	reverse transcriptase
F0344_RS07470	COG0494	nUDIX hydrolase
F0344_RS07480	COG0105	UTP biosynthetic process
F0344_RS07545	COG1278	Cold shock
F0344_RS07550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0344_RS07580	COG4974	Belongs to the 'phage' integrase family
F0344_RS07595	COG0154	amidase activity
F0344_RS07695	COG4974	Belongs to the 'phage' integrase family
F0344_RS07730	COG0151	Belongs to the GarS family
F0344_RS08005	COG0159	tryptophan synthase activity
F0344_RS08040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0344_RS08055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0344_RS08060	COG2358	TRAP transporter, solute receptor (TAXI family
F0344_RS08075	COG1126	abc transporter atp-binding protein
F0344_RS08080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0344_RS08085	COG0765	amino acid transport
F0344_RS08090	COG0765	amino acid transport
F0344_RS08130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0344_RS08170	COG1201	RNA secondary structure unwinding
F0344_RS08175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0344_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS08190	COG1396	sequence-specific DNA binding
F0344_RS08195	COG1546	Belongs to the CinA family
F0344_RS08195	COG1058	Belongs to the CinA family
F0344_RS08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0344_RS08215	COG1674	ftsk spoiiie
F0344_RS08225	COG3850	Histidine kinase
F0344_RS08225	COG2205	protein histidine kinase activity
F0344_RS08225	COG3437	response regulator, receiver
F0344_RS08225	COG4999	Histidine kinase
F0344_RS08230	COG2208	phosphoserine phosphatase activity
F0344_RS08230	COG2770	Histidine kinase
F0344_RS08255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F0344_RS08260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0344_RS08265	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F0344_RS08285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0344_RS08290	COG0612	Peptidase, M16
F0344_RS08295	COG1185	polyribonucleotide nucleotidyltransferase activity
F0344_RS08300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0344_RS08310	COG1674	ftsk spoiiie
F0344_RS08330	COG1404	Belongs to the peptidase S8 family
F0344_RS08335	COG3266	domain, Protein
F0344_RS08350	COG0455	bacterial-type flagellum organization
F0344_RS08355	COG0747	negative chemotaxis
F0344_RS08360	COG0601	transmembrane transport
F0344_RS08365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0344_RS08370	COG0444	Belongs to the ABC transporter superfamily
F0344_RS08390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0344_RS08395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0344_RS08405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0344_RS08420	COG0779	Required for maturation of 30S ribosomal subunits
F0344_RS08440	COG0442	prolyl-tRNA aminoacylation
F0344_RS08455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0344_RS08460	COG0750	zinc metalloprotease
F0344_RS08465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0344_RS08495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0344_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS08520	COG2508	Transcriptional regulator
F0344_RS08550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0344_RS08555	COG1177	transmembrane transport
F0344_RS08560	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0344_RS08565	COG3842	ATPase activity
F0344_RS08570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0344_RS08590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0344_RS08595	COG0584	glycerophosphoryl diester phosphodiesterase
F0344_RS08605	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS08615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0344_RS08620	COG4181	ATPase activity
F0344_RS08635	COG3842	ATPase activity
F0344_RS08650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F0344_RS08665	COG0233	cytoplasmic translational termination
F0344_RS08670	COG0528	UMP kinase activity
F0344_RS08675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0344_RS08680	COG0052	Belongs to the universal ribosomal protein uS2 family
F0344_RS08695	COG1191	sigma factor activity
F0344_RS08710	COG0792	nuclease activity
F0344_RS08720	COG1051	belongs to the nudix hydrolase family
F0344_RS08725	COG0681	Belongs to the peptidase S26 family
F0344_RS08730	COG0681	Belongs to the peptidase S26 family
F0344_RS08740	COG0681	Belongs to the peptidase S26 family
F0344_RS08750	COG0335	large ribosomal subunit rRNA binding
F0344_RS08755	COG0336	Belongs to the RNA methyltransferase TrmD family
F0344_RS08760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0344_RS08765	COG1837	Belongs to the UPF0109 family
F0344_RS08770	COG0228	four-way junction DNA binding
F0344_RS08790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0344_RS08825	COG0477	Major facilitator Superfamily
F0344_RS08830	COG1196	nuclear chromosome segregation
F0344_RS08840	COG1254	Belongs to the acylphosphatase family
F0344_RS08880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0344_RS08885	COG0571	ribonuclease III activity
F0344_RS08890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0344_RS08905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0344_RS08910	COG0742	ribosomal rna small subunit methyltransferase
F0344_RS08915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0344_RS08920	COG1461	Dihydroxyacetone kinase
F0344_RS08925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0344_RS08930	COG0351	phosphomethylpyrimidine kinase
F0344_RS08950	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0344_RS08955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0344_RS08965	COG1920	GTP binding
F0344_RS08975	COG0776	regulation of translation
F0344_RS08985	COG0066	3-isopropylmalate dehydratase activity
F0344_RS08990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0344_RS08995	COG1414	Transcriptional regulator
F0344_RS09030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0344_RS09035	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0344_RS09045	COG5002	protein histidine kinase activity
F0344_RS09050	COG2018	Roadblock/LC7 domain
F0344_RS09070	COG2018	Roadblock/LC7 domain
F0344_RS09090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0344_RS09095	COG0366	Alpha amylase catalytic
F0344_RS09095	COG1470	cell adhesion involved in biofilm formation
F0344_RS09140	COG1472	Belongs to the glycosyl hydrolase 3 family
F0344_RS09155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0344_RS09165	COG2957	Belongs to the agmatine deiminase family
F0344_RS09170	COG0804	urea catabolic process
F0344_RS09175	COG0831	urea catabolic process
F0344_RS09175	COG0832	Belongs to the urease beta subunit family
F0344_RS09180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0344_RS09185	COG0473	3-isopropylmalate dehydrogenase activity
F0344_RS09200	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS09205	COG0506	proline dehydrogenase activity
F0344_RS09210	COG3835	regulator
F0344_RS09230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0344_RS09235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0344_RS09240	COG0440	acetolactate synthase activity
F0344_RS09250	COG5001	Diguanylate cyclase
F0344_RS09250	COG3300	MHYT domain
F0344_RS09260	COG0667	Aldo Keto reductase
F0344_RS09265	COG2133	pyrroloquinoline quinone binding
F0344_RS09275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0344_RS09280	COG2409	Drug exporters of the RND superfamily
F0344_RS09290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F0344_RS09300	COG0154	amidase activity
F0344_RS09305	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F0344_RS09315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0344_RS09325	COG4221	oxidoreductase activity
F0344_RS09345	COG0482	sulfurtransferase activity
F0344_RS09370	COG0006	proline dipeptidase activity
F0344_RS09385	COG2860	membrane
F0344_RS09390	COG4608	Belongs to the ABC transporter superfamily
F0344_RS09395	COG0444	Belongs to the ABC transporter superfamily
F0344_RS09400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0344_RS09405	COG0601	transmembrane transport
F0344_RS09410	COG0747	negative chemotaxis
F0344_RS09430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0344_RS09435	COG0509	glycine decarboxylation via glycine cleavage system
F0344_RS09440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0344_RS09445	COG1760	l-serine dehydratase
F0344_RS09485	COG0513	Belongs to the DEAD box helicase family
F0344_RS09490	COG1278	Cold shock
F0344_RS09540	COG1376	ErfK ybiS ycfS ynhG family protein
F0344_RS09550	COG1132	(ABC) transporter
F0344_RS09555	COG1132	(ABC) transporter
F0344_RS09565	COG0058	SHG alpha-glucan phosphorylase activity
F0344_RS09570	COG0366	Alpha amylase catalytic
F0344_RS09575	COG0366	Alpha amylase catalytic
F0344_RS09580	COG3281	Trehalose synthase
F0344_RS09585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0344_RS09625	COG3118	belongs to the thioredoxin family
F0344_RS09635	COG2814	Major facilitator Superfamily
F0344_RS09645	COG1301	dicarboxylic acid transport
F0344_RS09650	COG3290	protein histidine kinase activity
F0344_RS09655	COG4565	transcriptional regulatory protein
F0344_RS09665	COG0205	6-phosphofructokinase activity
F0344_RS09670	COG0857	belongs to the CobB CobQ family
F0344_RS09670	COG0280	phosphate acetyltransferase
F0344_RS09675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0344_RS09705	COG3118	belongs to the thioredoxin family
F0344_RS09715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS09715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS09800	COG0183	Belongs to the thiolase family
F0344_RS09855	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F0344_RS09870	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0344_RS09885	COG4585	Histidine kinase
F0344_RS09890	COG2197	response regulator
F0344_RS09905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0344_RS09910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0344_RS09915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0344_RS09920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0344_RS09925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0344_RS09930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0344_RS09935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0344_RS09950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0344_RS09955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0344_RS09960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0344_RS09970	COG2890	protein-(glutamine-N5) methyltransferase activity
F0344_RS09975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0344_RS09980	COG0254	rRNA binding
F0344_RS09995	COG0083	homoserine kinase activity
F0344_RS10000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F0344_RS10005	COG0460	homoserine dehydrogenase
F0344_RS10010	COG0019	diaminopimelate decarboxylase activity
F0344_RS10015	COG0018	arginyl-trna synthetase
F0344_RS10035	COG2755	lipolytic protein G-D-S-L family
F0344_RS10045	COG3191	aminopeptidase activity
F0344_RS10080	COG0367	asparagine synthase
F0344_RS10085	COG1032	radical SAM domain protein
F0344_RS10100	COG0583	DNA-binding transcription factor activity
F0344_RS10115	COG0456	acetyltransferase
F0344_RS10155	COG2318	DinB family
F0344_RS10225	COG3344	reverse transcriptase
F0344_RS10265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F0344_RS10270	COG1793	dna ligase
F0344_RS10270	COG3285	dna ligase
F0344_RS10295	COG0768	penicillin binding
F0344_RS10325	COG1309	transcriptional regulator
F0344_RS10365	COG5002	protein histidine kinase activity
F0344_RS10385	COG0726	polysaccharide deacetylase
F0344_RS10390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0344_RS10410	COG0745	RESPONSE REGULATOR receiver
F0344_RS10415	COG2205	protein histidine kinase activity
F0344_RS10420	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0344_RS10420	COG0567	Dehydrogenase, E1 component
F0344_RS10450	COG2255	four-way junction helicase activity
F0344_RS10495	COG0604	alcohol dehydrogenase
F0344_RS10500	COG0281	malic enzyme
F0344_RS10515	COG1126	abc transporter atp-binding protein
F0344_RS10525	COG4106	trans-aconitate 2-methyltransferase activity
F0344_RS10545	COG0582	viral genome integration into host DNA
F0344_RS10650	COG5640	endopeptidase activity
F0344_RS10665	COG0142	geranyltranstransferase activity
F0344_RS10670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0344_RS10675	COG1959	2 iron, 2 sulfur cluster binding
F0344_RS10680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0344_RS10680	COG1017	nitric oxide dioxygenase activity
F0344_RS10735	COG2172	sigma factor antagonist activity
F0344_RS10750	COG1597	lipid kinase activity
F0344_RS10770	COG0363	glucosamine-6-phosphate deaminase activity
F0344_RS10775	COG1472	Belongs to the glycosyl hydrolase 3 family
F0344_RS10780	COG0395	ABC-type sugar transport system, permease component
F0344_RS10785	COG1175	transmembrane transport
F0344_RS10790	COG2182	Extracellular solute-binding protein
F0344_RS10795	COG2188	Transcriptional regulator
F0344_RS10830	COG0242	peptide deformylase activity
F0344_RS10845	COG2199	diguanylate cyclase activity
F0344_RS10845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0344_RS10850	COG5662	AntiSigma factor
F0344_RS10855	COG1595	DNA-templated transcription, initiation
F0344_RS10865	COG2135	peptidase activity
F0344_RS10875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0344_RS10880	COG1162	GTPase activity
F0344_RS10885	COG2076	Multidrug Resistance protein
F0344_RS10890	COG0483	inositol monophosphate 1-phosphatase activity
F0344_RS10965	COG0753	catalase activity
F0344_RS10990	COG1615	UPF0182 protein
F0344_RS11000	COG3480	Lon protease (S16) C-terminal proteolytic domain
F0344_RS11050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0344_RS11055	COG1309	transcriptional regulator
F0344_RS11105	COG0210	DNA helicase
F0344_RS11195	COG0513	Belongs to the DEAD box helicase family
F0344_RS11205	COG1432	Conserved Protein
F0344_RS11215	COG2095	MarC family integral membrane protein
F0344_RS11220	COG0613	PHP domain protein
F0344_RS11235	COG0598	Magnesium transport protein CorA
F0344_RS11270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0344_RS11275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0344_RS11285	COG1595	DNA-templated transcription, initiation
F0344_RS11300	COG1024	Enoyl-CoA hydratase
F0344_RS11305	COG0519	Catalyzes the synthesis of GMP from XMP
F0344_RS11315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0344_RS11320	COG1611	Belongs to the LOG family
F0344_RS11325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0344_RS11355	COG2912	Transglutaminase-like superfamily
F0344_RS11385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F0344_RS11405	COG4608	Belongs to the ABC transporter superfamily
F0344_RS11415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0344_RS11420	COG0601	transmembrane transport
F0344_RS11425	COG4166	transmembrane transport
F0344_RS11430	COG4608	Belongs to the ABC transporter superfamily
F0344_RS11435	COG0444	Belongs to the ABC transporter superfamily
F0344_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0344_RS11450	COG4166	transmembrane transport
F0344_RS11475	COG1217	gtp-binding protein TYPA
F0344_RS11495	COG1053	succinate dehydrogenase
F0344_RS11520	COG1175	transmembrane transport
F0344_RS11525	COG0395	ABC-type sugar transport system, permease component
F0344_RS11545	COG1842	Phage shock protein A
F0344_RS11605	COG1024	Enoyl-CoA hydratase
F0344_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS11635	COG3409	Peptidoglycan-binding domain 1 protein
F0344_RS11650	COG2197	response regulator
F0344_RS11655	COG4585	Histidine kinase
F0344_RS11665	COG0577	efflux transmembrane transporter activity
F0344_RS11665	COG1136	(ABC) transporter
F0344_RS11695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0344_RS11700	COG2161	toxin-antitoxin pair type II binding
F0344_RS11705	COG4115	mRNA cleavage
F0344_RS11730	COG0012	GTP binding
F0344_RS11745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0344_RS11755	COG1570	exodeoxyribonuclease VII activity
F0344_RS11760	COG1722	exodeoxyribonuclease VII activity
F0344_RS11765	COG0778	Nitroreductase
F0344_RS11790	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F0344_RS11790	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F0344_RS11815	COG1362	aminopeptidase activity
F0344_RS11830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS11840	COG0114	fumarate hydratase activity
F0344_RS11865	COG1136	(ABC) transporter
F0344_RS11880	COG0450	alkyl hydroperoxide reductase
F0344_RS11885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0344_RS11900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0344_RS11905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0344_RS11910	COG0667	Aldo Keto reductase
F0344_RS11930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F0344_RS11950	COG4166	transmembrane transport
F0344_RS12005	COG0675	Transposase, IS605 OrfB family
F0344_RS12040	COG1396	sequence-specific DNA binding
F0344_RS12045	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
F0344_RS12055	COG2885	chlorophyll binding
F0344_RS12075	COG2197	response regulator
F0344_RS12170	COG2610	gluconate transmembrane transporter activity
F0344_RS12175	COG0251	oxidation-reduction process
F0344_RS12180	COG1414	Transcriptional regulator
F0344_RS12195	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F0344_RS12200	COG1733	regulation of RNA biosynthetic process
F0344_RS12225	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F0344_RS12235	COG1331	Highly conserved protein containing a thioredoxin domain
F0344_RS12255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F0344_RS12265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0344_RS12275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0344_RS12280	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F0344_RS12605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0344_RS12655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F0344_RS12660	COG2255	four-way junction helicase activity
F0344_RS12665	COG1595	DNA-templated transcription, initiation
F0344_RS12690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0344_RS12725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0344_RS12745	COG1376	ErfK ybiS ycfS ynhG family protein
F0344_RS12770	COG1024	Enoyl-CoA hydratase
F0344_RS12785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0344_RS12795	COG0424	maF-like protein
F0344_RS12805	COG4770	biotin carboxylase activity
F0344_RS12835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0344_RS12855	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS12875	COG1595	DNA-templated transcription, initiation
F0344_RS12880	COG0745	RESPONSE REGULATOR receiver
F0344_RS12885	COG2205	protein histidine kinase activity
F0344_RS12910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0344_RS12925	COG0583	DNA-binding transcription factor activity
F0344_RS12930	COG2814	Major facilitator Superfamily
F0344_RS12950	COG1404	Belongs to the peptidase S8 family
F0344_RS12965	COG1079	Belongs to the binding-protein-dependent transport system permease family
F0344_RS12970	COG4603	Belongs to the binding-protein-dependent transport system permease family
F0344_RS12975	COG3845	ABC transporter
F0344_RS12980	COG1744	ABC transporter substrate-binding protein PnrA-like
F0344_RS12985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F0344_RS12985	COG1473	amidohydrolase
F0344_RS13000	COG2089	acid synthase
F0344_RS13005	COG1083	cytidylyl-transferase
F0344_RS13015	COG1216	Glycosyl transferase, family 2
F0344_RS13035	COG1216	Glycosyl transferase, family 2
F0344_RS13085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS13085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS13100	COG1595	DNA-templated transcription, initiation
F0344_RS13175	COG2009	succinate dehydrogenase
F0344_RS13190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0344_RS13210	COG1309	transcriptional regulator
F0344_RS13230	COG0747	negative chemotaxis
F0344_RS13235	COG1408	metallophosphoesterase
F0344_RS13240	COG1686	Belongs to the peptidase S11 family
F0344_RS13245	COG1295	ribonuclease BN
F0344_RS13265	COG0180	Tryptophanyl-tRNA synthetase
F0344_RS13270	COG1595	DNA-templated transcription, initiation
F0344_RS13280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0344_RS13285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0344_RS13290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0344_RS13300	COG0039	L-malate dehydrogenase activity
F0344_RS13315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0344_RS13330	COG0138	bifunctional purine biosynthesis protein purh
F0344_RS13360	COG0045	succinate-CoA ligase (ADP-forming) activity
F0344_RS13370	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F0344_RS13375	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0344_RS13380	COG0714	Associated with various cellular activities
F0344_RS13395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS13395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0344_RS13405	COG0739	heme binding
F0344_RS13430	COG3971	2-oxopent-4-enoate hydratase activity
F0344_RS13435	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F0344_RS13445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0344_RS13455	COG2301	Belongs to the HpcH HpaI aldolase family
F0344_RS13485	COG2197	response regulator
F0344_RS13530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0344_RS13530	COG0519	Catalyzes the synthesis of GMP from XMP
F0344_RS13550	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS13555	COG0515	serine threonine protein kinase
F0344_RS13585	COG0516	GMP reductase activity
F0344_RS13595	COG1595	DNA-templated transcription, initiation
F0344_RS13600	COG2197	response regulator
F0344_RS13610	COG0583	DNA-binding transcription factor activity
F0344_RS13620	COG4221	oxidoreductase activity
F0344_RS13635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0344_RS13640	COG0726	polysaccharide deacetylase
F0344_RS13660	COG4941	Belongs to the sigma-70 factor family
F0344_RS13675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0344_RS13700	COG0802	atpase or kinase
F0344_RS13710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0344_RS13720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0344_RS13720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0344_RS13725	COG0736	holo-[acyl-carrier-protein] synthase activity
F0344_RS13730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0344_RS13745	COG1072	(Pantothenic acid kinase))
F0344_RS13755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0344_RS13760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0344_RS13765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0344_RS13770	COG0488	(ABC) transporter
F0344_RS13780	COG0101	tRNA pseudouridine synthase activity
F0344_RS13785	COG0203	ribosomal protein L17
F0344_RS13790	COG0202	RNA polymerase activity
F0344_RS13795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0344_RS13800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0344_RS13805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0344_RS13810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0344_RS13820	COG0563	adenylate kinase activity
F0344_RS13830	COG0200	Binds to the 23S rRNA
F0344_RS13835	COG1841	ribosomal large subunit assembly
F0344_RS13840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0344_RS13845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0344_RS13850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0344_RS13855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0344_RS13860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0344_RS13865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0344_RS13870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0344_RS13875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0344_RS13880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0344_RS13885	COG0255	Belongs to the universal ribosomal protein uL29 family
F0344_RS13890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0344_RS13895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0344_RS13900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0344_RS13905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0344_RS13910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0344_RS13915	COG0089	rRNA binding
F0344_RS13920	COG0088	Forms part of the polypeptide exit tunnel
F0344_RS13925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0344_RS13930	COG0051	transcription antitermination factor activity, RNA binding
F0344_RS13965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0344_RS13970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0344_RS13975	COG0049	tRNA binding
F0344_RS13980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0344_RS13985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0344_RS13990	COG0085	RNA polymerase activity
F0344_RS13995	COG0222	ribosome binding
F0344_RS14000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0344_RS14005	COG0081	regulation of translation
F0344_RS14010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0344_RS14030	COG0436	Aminotransferase
F0344_RS14035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0344_RS14040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0344_RS14045	COG0477	Major facilitator Superfamily
F0344_RS14060	COG2030	dehydratase
F0344_RS14065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0344_RS14085	COG0702	epimerase
F0344_RS14095	COG1666	GTP binding
F0344_RS14100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0344_RS14115	COG2261	transglycosylase associated protein
F0344_RS14120	COG3304	Inner membrane component domain
F0344_RS14125	COG0501	Belongs to the peptidase M48B family
F0344_RS14130	COG1970	mechanosensitive ion channel activity
F0344_RS14135	COG1007	ATP synthesis coupled electron transport
F0344_RS14150	COG0713	ATP synthesis coupled electron transport
F0344_RS14155	COG0839	Belongs to the complex I subunit 6 family
F0344_RS14160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0344_RS14170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14200	COG0674	pyruvate-flavodoxin oxidoreductase activity
F0344_RS14200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F0344_RS14205	COG1013	pyruvate-flavodoxin oxidoreductase activity
F0344_RS14235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0344_RS14280	COG0561	phosphatase activity
F0344_RS14310	COG0142	geranyltranstransferase activity
F0344_RS14325	COG0514	ATP-dependent DNA helicase (RecQ)
F0344_RS14330	COG1007	ATP synthesis coupled electron transport
F0344_RS14340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0344_RS14345	COG0713	ATP synthesis coupled electron transport
F0344_RS14350	COG0839	Belongs to the complex I subunit 6 family
F0344_RS14355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0344_RS14365	COG1034	ATP synthesis coupled electron transport
F0344_RS14370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F0344_RS14380	COG0649	NAD binding
F0344_RS14385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0344_RS14430	COG2226	methyltransferase
F0344_RS14440	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F0344_RS14450	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F0344_RS14455	COG1278	Cold shock
F0344_RS14490	COG1024	Enoyl-CoA hydratase
F0344_RS14505	COG0515	serine threonine protein kinase
F0344_RS14505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0344_RS14515	COG1309	transcriptional regulator
F0344_RS14525	COG1960	acyl-CoA dehydrogenase activity
F0344_RS14535	COG0259	pyridoxamine-phosphate oxidase activity
F0344_RS14540	COG0501	Belongs to the peptidase M48B family
F0344_RS14560	COG2072	flavoprotein involved in K transport
F0344_RS14590	COG0702	epimerase
F0344_RS14620	COG1024	Enoyl-CoA hydratase
F0344_RS14645	COG1960	acyl-CoA dehydrogenase activity
F0344_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS14665	COG1960	acyl-CoA dehydrogenase activity
F0344_RS14670	COG1960	acyl-CoA dehydrogenase activity
F0344_RS14690	COG2856	Zn peptidase
F0344_RS14705	COG1366	Belongs to the anti-sigma-factor antagonist family
F0344_RS14775	COG4821	SIS domain
F0344_RS14785	COG0259	pyridoxamine-phosphate oxidase activity
F0344_RS14800	COG1024	Enoyl-CoA hydratase
F0344_RS14800	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0344_RS14805	COG0318	PFAM AMP-dependent synthetase and ligase
F0344_RS14820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0344_RS14835	COG1051	belongs to the nudix hydrolase family
F0344_RS14845	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
F0344_RS14860	COG5006	permease, DMT superfamily
F0344_RS14870	COG1316	TRANSCRIPTIONal
F0344_RS14875	COG2205	protein histidine kinase activity
F0344_RS14905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0344_RS14915	COG2318	DinB family
F0344_RS14925	COG2226	methyltransferase
F0344_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS15015	COG2267	carboxylic ester hydrolase activity
F0344_RS15020	COG0667	Aldo Keto reductase
F0344_RS15035	COG1846	Transcriptional regulator
F0344_RS15045	COG2252	PERMEase
F0344_RS15055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0344_RS15075	COG2814	Major facilitator Superfamily
F0344_RS15085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0344_RS15090	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F0344_RS15095	COG1278	Cold shock
F0344_RS15125	COG1061	Type III restriction enzyme res subunit
F0344_RS15135	COG3973	AAA domain
F0344_RS15170	COG1737	Transcriptional regulator
F0344_RS15175	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0344_RS15245	COG3973	AAA domain
F0344_RS15255	COG1846	Transcriptional regulator
F0344_RS15260	COG0697	spore germination
F0344_RS15265	COG2910	NAD(P)H-binding
F0344_RS15305	COG0463	Glycosyl transferase, family 2
F0344_RS15345	COG1653	transport
F0344_RS15385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F0344_RS15405	COG4585	Histidine kinase
F0344_RS15410	COG2197	response regulator
F0344_RS15440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0344_RS15455	COG2318	DinB family
F0344_RS15490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0344_RS15500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS15505	COG2124	cytochrome p450
F0344_RS15535	COG2175	clavaminate synthase activity
F0344_RS15545	COG3251	PFAM MbtH domain protein
F0344_RS15550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS15550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS15555	COG2814	Major facilitator Superfamily
F0344_RS15585	COG3842	ATPase activity
F0344_RS15595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0344_RS15610	COG0215	cysteine-tRNA ligase activity
F0344_RS15615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0344_RS15620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0344_RS15625	COG1329	Transcriptional regulator
F0344_RS15640	COG5002	protein histidine kinase activity
F0344_RS15655	COG0588	phosphoglycerate mutase activity
F0344_RS15700	COG0438	transferase activity, transferring glycosyl groups
F0344_RS15740	COG0110	maltose O-acetyltransferase activity
F0344_RS15760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0344_RS15775	COG4552	Acetyltransferase involved in intracellular survival and related
F0344_RS15790	COG1490	D-aminoacyl-tRNA deacylase activity
F0344_RS15795	COG0354	folic acid binding
F0344_RS15805	COG3485	protocatechuate 3,4-dioxygenase
F0344_RS15840	COG2897	thiosulfate sulfurtransferase activity
F0344_RS15865	COG0745	RESPONSE REGULATOR receiver
F0344_RS15870	COG1609	Transcriptional regulator
F0344_RS15875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0344_RS15900	COG0737	Belongs to the 5'-nucleotidase family
F0344_RS15905	COG0456	acetyltransferase
F0344_RS15910	COG1725	Transcriptional regulator
F0344_RS15935	COG0494	nUDIX hydrolase
F0344_RS15935	COG0406	alpha-ribazole phosphatase activity
F0344_RS15940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0344_RS15955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0344_RS15960	COG0306	phosphate transporter
F0344_RS15970	COG1937	Protein conserved in bacteria
F0344_RS15995	COG0671	phosphoesterase, PA-phosphatase related
F0344_RS16000	COG1196	nuclear chromosome segregation
F0344_RS16000	COG0741	lytic transglycosylase activity
F0344_RS16000	COG0739	heme binding
F0344_RS16020	COG0667	Aldo Keto reductase
F0344_RS16060	COG0456	acetyltransferase
F0344_RS16080	COG1846	Transcriptional regulator
F0344_RS16120	COG0579	oxidoreductase
F0344_RS16140	COG1196	nuclear chromosome segregation
F0344_RS16140	COG0741	lytic transglycosylase activity
F0344_RS16140	COG0739	heme binding
F0344_RS16215	COG0513	Belongs to the DEAD box helicase family
F0344_RS16225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0344_RS16230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0344_RS16260	COG0785	Cytochrome C biogenesis protein
F0344_RS16265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0344_RS16265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0344_RS16275	COG1643	Atp-dependent helicase
F0344_RS16305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0344_RS16335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0344_RS16340	COG0047	phosphoribosylformylglycinamidine synthase activity
F0344_RS16345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0344_RS16375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0344_RS16390	COG0151	Belongs to the GarS family
F0344_RS16470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0344_RS16485	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
F0344_RS16520	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0344_RS16635	COG2824	Alkylphosphonate utilization operon protein PhnA
F0344_RS16655	COG0659	secondary active sulfate transmembrane transporter activity
F0344_RS16670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0344_RS16685	COG0596	Alpha beta hydrolase
F0344_RS16700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0344_RS16720	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F0344_RS16760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0344_RS16855	COG2188	Transcriptional regulator
F0344_RS16860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0344_RS16880	COG1191	sigma factor activity
F0344_RS16885	COG1191	sigma factor activity
F0344_RS16910	COG2353	YceI-like domain
F0344_RS16915	COG3467	pyridoxamine 5'-phosphate
F0344_RS16930	COG0477	Major facilitator Superfamily
F0344_RS16935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F0344_RS16945	COG2205	protein histidine kinase activity
F0344_RS16950	COG0745	RESPONSE REGULATOR receiver
F0344_RS16970	COG1595	DNA-templated transcription, initiation
F0344_RS16975	COG1252	NADH dehydrogenase
F0344_RS16990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0344_RS16995	COG2188	Transcriptional regulator
F0344_RS17080	COG0318	PFAM AMP-dependent synthetase and ligase
F0344_RS17085	COG1595	DNA-templated transcription, initiation
F0344_RS17110	COG1960	acyl-CoA dehydrogenase activity
F0344_RS17180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0344_RS17195	COG0653	protein targeting
F0344_RS17215	COG0006	proline dipeptidase activity
F0344_RS17235	COG1999	signal sequence binding
F0344_RS17245	COG2372	response to copper ion
F0344_RS17250	COG2837	iron assimilation
F0344_RS17255	COG0077	Prephenate dehydratase
F0344_RS17260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0344_RS17265	COG0561	phosphatase activity
F0344_RS17310	COG0789	Transcriptional regulator
F0344_RS17315	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F0344_RS17360	COG1192	Involved in chromosome partitioning
F0344_RS17380	COG0515	serine threonine protein kinase
F0344_RS17380	COG2815	serine threonine protein kinase
F0344_RS17395	COG0494	nUDIX hydrolase
F0344_RS17435	COG0242	peptide deformylase activity
F0344_RS17465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0344_RS17475	COG0561	phosphatase activity
F0344_RS17485	COG4988	ABC transporter
F0344_RS17490	COG1294	oxidase, subunit
F0344_RS17495	COG1271	oxidase subunit
F0344_RS17500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0344_RS17505	COG1609	Transcriptional regulator
F0344_RS17510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0344_RS17520	COG3152	Membrane
F0344_RS17525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0344_RS17550	COG0662	Cupin 2, conserved barrel domain protein
F0344_RS17555	COG1950	PFAM Membrane protein of
F0344_RS17560	COG0626	cystathionine gamma-synthase activity
F0344_RS17610	COG0305	Participates in initiation and elongation during chromosome replication
F0344_RS17615	COG0534	Mate efflux family protein
F0344_RS17620	COG0359	binds to the 23S rRNA
F0344_RS17625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0344_RS17630	COG0629	single-stranded DNA binding
F0344_RS17635	COG0360	Binds together with S18 to 16S ribosomal RNA
F0344_RS17660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0344_RS17680	COG0617	tRNA 3'-terminal CCA addition
F0344_RS17695	COG2815	serine threonine protein kinase
F0344_RS17695	COG0515	serine threonine protein kinase
F0344_RS17700	COG1595	DNA-templated transcription, initiation
F0344_RS17710	COG0492	ferredoxin-NADP+ reductase activity
F0344_RS17715	COG3118	belongs to the thioredoxin family
F0344_RS17730	COG1192	Involved in chromosome partitioning
F0344_RS17735	COG0357	Ribosomal RNA small subunit methyltransferase G
F0344_RS17745	COG0706	membrane insertase activity
F0344_RS17750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F0344_RS17755	COG0594	ribonuclease P activity
F0344_RS17760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0344_RS17770	COG0592	DNA-directed DNA polymerase activity
F0344_RS17775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F0344_RS17780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0344_RS17785	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F0344_RS17795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0344_RS17830	COG0515	serine threonine protein kinase
F0344_RS17860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0344_RS17895	COG4326	sporulation control protein
F0344_RS17940	COG0705	Rhomboid family
F0344_RS17955	COG3764	Sortase (surface protein transpeptidase)
F0344_RS17970	COG3764	Sortase (surface protein transpeptidase)
F0344_RS17975	COG3764	Sortase (surface protein transpeptidase)
F0344_RS17980	COG0515	serine threonine protein kinase
F0344_RS17985	COG0768	penicillin binding
F0344_RS18000	COG1716	ATPase activity
F0344_RS18005	COG1716	ATPase activity
F0344_RS18035	COG1960	acyl-CoA dehydrogenase activity
F0344_RS18040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0344_RS18045	COG2151	metal-sulfur cluster biosynthetic enzyme
F0344_RS18050	COG3396	Phenylacetate-CoA oxygenase
F0344_RS18055	COG3460	Phenylacetate-CoA oxygenase
F0344_RS18060	COG3396	Phenylacetate-CoA oxygenase
F0344_RS18085	COG1309	transcriptional regulator
F0344_RS18090	COG1522	sequence-specific DNA binding
F0344_RS18105	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0344_RS18110	COG0746	molybdenum cofactor guanylyltransferase activity
F0344_RS18120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0344_RS18125	COG0604	alcohol dehydrogenase
F0344_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS18125	COG3321	synthase
F0344_RS18140	COG1136	(ABC) transporter
F0344_RS18140	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0344_RS18155	COG0515	serine threonine protein kinase
F0344_RS18160	COG0515	serine threonine protein kinase
F0344_RS18185	COG0022	dehydrogenase e1 component
F0344_RS18190	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0344_RS18235	COG3629	intracellular signal transduction
F0344_RS18235	COG3903	Transcriptional regulator
F0344_RS18245	COG1362	aminopeptidase activity
F0344_RS18250	COG1960	acyl-CoA dehydrogenase activity
F0344_RS18260	COG1741	Belongs to the pirin family
F0344_RS18275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0344_RS18285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0344_RS18305	COG1289	transmembrane transporter activity
F0344_RS18355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0344_RS18365	COG0180	Tryptophanyl-tRNA synthetase
F0344_RS18400	COG2268	Band 7 protein
F0344_RS18465	COG5002	protein histidine kinase activity
F0344_RS18470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0344_RS18475	COG1278	Cold shock
F0344_RS18480	COG0513	Belongs to the DEAD box helicase family
F0344_RS18490	COG3594	Acyltransferase
F0344_RS18580	COG3693	PFAM glycoside hydrolase, family 10
F0344_RS18725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F0344_RS18760	COG0717	Belongs to the dCTP deaminase family
F0344_RS18765	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F0344_RS18780	COG0247	lactate metabolic process
F0344_RS18780	COG2181	nitrate reductase activity
F0344_RS18785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0344_RS18790	COG0443	Heat shock 70 kDa protein
F0344_RS18795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0344_RS18800	COG0484	heat shock protein binding
F0344_RS18805	COG0789	Transcriptional regulator
F0344_RS18830	COG0542	response to heat
F0344_RS18850	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F0344_RS18865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0344_RS18870	COG0191	fructose-bisphosphate aldolase activity
F0344_RS18890	COG3844	kynureninase activity
F0344_RS18900	COG4585	Histidine kinase
F0344_RS18905	COG2197	response regulator
F0344_RS18920	COG3559	Exporter of polyketide antibiotics
F0344_RS18925	COG1131	(ABC) transporter
F0344_RS18940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0344_RS18950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0344_RS18965	COG0592	DNA-directed DNA polymerase activity
F0344_RS19005	COG0693	protein deglycase activity
F0344_RS19010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0344_RS19015	COG1802	Transcriptional regulator
F0344_RS19030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0344_RS19035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0344_RS19055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0344_RS19060	COG1595	DNA-templated transcription, initiation
F0344_RS19080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0344_RS19085	COG2755	lipolytic protein G-D-S-L family
F0344_RS19100	COG3547	Transposase (IS116 IS110 IS902 family)
F0344_RS19150	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0344_RS19160	COG3547	Transposase (IS116 IS110 IS902 family)
F0344_RS19170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0344_RS19175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0344_RS19185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0344_RS19215	COG4106	trans-aconitate 2-methyltransferase activity
F0344_RS19265	COG3547	Transposase (IS116 IS110 IS902 family)
F0344_RS19285	COG1609	Transcriptional regulator
F0344_RS19315	COG1408	metallophosphoesterase
F0344_RS19320	COG1610	YqeY-like protein
F0344_RS19325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0344_RS19335	COG0003	Pfam Anion-transporting ATPase
F0344_RS19350	COG0251	oxidation-reduction process
F0344_RS19360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0344_RS19385	COG2267	carboxylic ester hydrolase activity
F0344_RS19395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0344_RS19400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0344_RS19405	COG0288	reversible hydration of carbon dioxide
F0344_RS19465	COG1205	dead DEAH box helicase
F0344_RS19465	COG1111	helicase
F0344_RS19470	COG1366	Belongs to the anti-sigma-factor antagonist family
F0344_RS19485	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F0344_RS19505	COG1754	DNA topoisomerase type I activity
F0344_RS19505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0344_RS19510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0344_RS19515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0344_RS19555	COG2192	nodulation
F0344_RS19560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0344_RS19570	COG1063	alcohol dehydrogenase
F0344_RS19580	COG0463	Glycosyl transferase, family 2
F0344_RS19595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0344_RS19600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0344_RS19640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0344_RS19830	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0344_RS19905	COG0791	NLP P60 protein
F0344_RS19905	COG3103	Sh3 type 3 domain protein
F0344_RS19905	COG1388	LysM domain
F0344_RS19955	COG1487	ribonuclease activity
F0344_RS20000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F0344_RS20005	COG2897	thiosulfate sulfurtransferase activity
F0344_RS20015	COG2197	response regulator
F0344_RS20060	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS20065	COG2318	DinB family
F0344_RS20085	COG0076	glutamate decarboxylase activity
F0344_RS20090	COG0789	Transcriptional regulator
F0344_RS20095	COG0393	Putative heavy-metal-binding
F0344_RS20110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0344_RS20115	COG2027	D-alanyl-D-alanine carboxypeptidase
F0344_RS20125	COG0037	tRNA processing
F0344_RS20140	COG0302	gtp cyclohydrolase
F0344_RS20150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0344_RS20155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0344_RS20170	COG1125	glycine betaine transport
F0344_RS20170	COG0517	IMP dehydrogenase activity
F0344_RS20175	COG1174	glycine betaine transport
F0344_RS20180	COG1174	glycine betaine transport
F0344_RS20185	COG1732	Glycine betaine
F0344_RS20195	COG0649	NAD binding
F0344_RS20210	COG2197	response regulator
F0344_RS20225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0344_RS20230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0344_RS20240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F0344_RS20260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0344_RS20290	COG0739	heme binding
F0344_RS20300	COG2205	protein histidine kinase activity
F0344_RS20305	COG0745	RESPONSE REGULATOR receiver
F0344_RS20315	COG3547	Transposase (IS116 IS110 IS902 family)
F0344_RS20325	COG1595	DNA-templated transcription, initiation
F0344_RS20330	COG1194	a g-specific adenine glycosylase
F0344_RS20345	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F0344_RS20365	COG0248	Ppx GppA phosphatase
F0344_RS20370	COG1082	Xylose isomerase domain protein TIM barrel
F0344_RS20380	COG0129	dihydroxy-acid dehydratase activity
F0344_RS20385	COG0515	serine threonine protein kinase
F0344_RS20385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0344_RS20405	COG0842	Transport permease protein
F0344_RS20405	COG1129	ABC transporter
F0344_RS20415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0344_RS20445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0344_RS20505	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F0344_RS20510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0344_RS20515	COG0181	hydroxymethylbilane synthase activity
F0344_RS20520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0344_RS20520	COG1648	precorrin-2 dehydrogenase activity
F0344_RS20525	COG0113	porphobilinogen synthase activity
F0344_RS20540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0344_RS20550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0344_RS20590	COG0018	arginyl-trna synthetase
F0344_RS20595	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F0344_RS20615	COG1690	Belongs to the RtcB family
F0344_RS20625	COG1742	UPF0060 membrane protein
F0344_RS20660	COG0640	Transcriptional regulator
F0344_RS20670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0344_RS20675	COG0406	alpha-ribazole phosphatase activity
F0344_RS20685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0344_RS20690	COG0785	Cytochrome C biogenesis protein
F0344_RS20695	COG1333	cytochrome c biogenesis protein
F0344_RS20700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0344_RS20725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0344_RS20730	COG0109	protoheme IX farnesyltransferase activity
F0344_RS20735	COG0705	Rhomboid family
F0344_RS20740	COG0163	prenyltransferase activity
F0344_RS20755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F0344_RS20760	COG2205	protein histidine kinase activity
F0344_RS20765	COG1136	(ABC) transporter
F0344_RS20765	COG0577	efflux transmembrane transporter activity
F0344_RS20770	COG0577	efflux transmembrane transporter activity
F0344_RS20770	COG1136	(ABC) transporter
F0344_RS20805	COG1301	dicarboxylic acid transport
F0344_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS20840	COG1196	nuclear chromosome segregation
F0344_RS20840	COG0741	lytic transglycosylase activity
F0344_RS20840	COG0739	heme binding
F0344_RS20905	COG0768	penicillin binding
F0344_RS20920	COG1011	Hydrolase
F0344_RS20925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F0344_RS20965	COG1686	Belongs to the peptidase S11 family
F0344_RS21050	COG0492	ferredoxin-NADP+ reductase activity
F0344_RS21060	COG2175	clavaminate synthase activity
F0344_RS21065	COG0010	Belongs to the arginase family
F0344_RS21070	COG0367	asparagine synthase
F0344_RS21080	COG0583	DNA-binding transcription factor activity
F0344_RS21135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0344_RS21140	COG0747	negative chemotaxis
F0344_RS21145	COG4221	oxidoreductase activity
F0344_RS21165	COG0697	spore germination
F0344_RS21185	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0344_RS21190	COG0768	penicillin binding
F0344_RS21195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0344_RS21245	COG1846	Transcriptional regulator
F0344_RS21250	COG3384	dioxygenase
F0344_RS21255	COG1247	-acetyltransferase
F0344_RS21270	COG0477	Major facilitator Superfamily
F0344_RS21295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F0344_RS21320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0344_RS21325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0344_RS21335	COG0315	cyclic pyranopterin monophosphate synthase activity
F0344_RS21340	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0344_RS21340	COG0315	cyclic pyranopterin monophosphate synthase activity
F0344_RS21415	COG0708	Exodeoxyribonuclease III
F0344_RS21425	COG2072	flavoprotein involved in K transport
F0344_RS21430	COG2267	carboxylic ester hydrolase activity
F0344_RS21435	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS21445	COG0793	Belongs to the peptidase S41A family
F0344_RS21445	COG4946	Tricorn protease homolog
F0344_RS21450	COG1309	transcriptional regulator
F0344_RS21455	COG2409	Drug exporters of the RND superfamily
F0344_RS21465	COG0310	cobalt ion transport
F0344_RS21475	COG1122	ATPase activity
F0344_RS21480	COG1846	Transcriptional regulator
F0344_RS21485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0344_RS21495	COG3842	ATPase activity
F0344_RS21505	COG1840	ABC-type Fe3 transport system, periplasmic component
F0344_RS21510	COG0318	PFAM AMP-dependent synthetase and ligase
F0344_RS21530	COG0442	prolyl-tRNA aminoacylation
F0344_RS21555	COG0084	hydrolase, TatD family'
F0344_RS21565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0344_RS21570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F0344_RS21575	COG2161	toxin-antitoxin pair type II binding
F0344_RS21585	COG0488	(ABC) transporter
F0344_RS21615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0344_RS21630	COG1846	Transcriptional regulator
F0344_RS21645	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0344_RS21655	COG0193	aminoacyl-tRNA hydrolase activity
F0344_RS21660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0344_RS21665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0344_RS21670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0344_RS21685	COG4585	Histidine kinase
F0344_RS21725	COG1136	(ABC) transporter
F0344_RS21730	COG0577	efflux transmembrane transporter activity
F0344_RS21765	COG2815	serine threonine protein kinase
F0344_RS21765	COG0515	serine threonine protein kinase
F0344_RS21780	COG2124	cytochrome p450
F0344_RS21795	COG0148	phosphopyruvate hydratase activity
F0344_RS21815	COG1252	NADH dehydrogenase
F0344_RS21820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0344_RS21825	COG0577	efflux transmembrane transporter activity
F0344_RS21825	COG1136	(ABC) transporter
F0344_RS21830	COG0577	efflux transmembrane transporter activity
F0344_RS21830	COG1136	(ABC) transporter
F0344_RS21835	COG1609	Transcriptional regulator
F0344_RS21870	COG0183	Belongs to the thiolase family
F0344_RS21915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0344_RS21920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0344_RS21930	COG1228	amidohydrolase
F0344_RS21935	COG1191	sigma factor activity
F0344_RS21940	COG1366	Belongs to the anti-sigma-factor antagonist family
F0344_RS21975	COG3104	oligopeptide transport
F0344_RS21980	COG0745	RESPONSE REGULATOR receiver
F0344_RS21985	COG2205	protein histidine kinase activity
F0344_RS22010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F0344_RS22130	COG1316	TRANSCRIPTIONal
F0344_RS22140	COG1316	TRANSCRIPTIONal
F0344_RS22155	COG1316	TRANSCRIPTIONal
F0344_RS22160	COG1316	TRANSCRIPTIONal
F0344_RS22185	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F0344_RS22185	COG0778	Nitroreductase
F0344_RS22190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0344_RS22225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0344_RS22250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F0344_RS22290	COG0714	Associated with various cellular activities
F0344_RS22310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F0344_RS22315	COG0745	RESPONSE REGULATOR receiver
F0344_RS22320	COG5002	protein histidine kinase activity
F0344_RS22325	COG0823	Involved in the tonB-independent uptake of proteins
F0344_RS22335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0344_RS22340	COG2197	response regulator
F0344_RS22355	COG0653	protein targeting
F0344_RS22380	COG2902	Dehydrogenase
F0344_RS22385	COG1216	Glycosyl transferase, family 2
F0344_RS22390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0344_RS22405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0344_RS22410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0344_RS22415	COG0438	transferase activity, transferring glycosyl groups
F0344_RS22420	COG0463	Glycosyl transferase, family 2
F0344_RS22420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0344_RS22425	COG0395	ABC-type sugar transport system, permease component
F0344_RS22430	COG1175	transmembrane transport
F0344_RS22435	COG1653	transport
F0344_RS22440	COG1674	ftsk spoiiie
F0344_RS22445	COG0515	serine threonine protein kinase
F0344_RS22450	COG0515	serine threonine protein kinase
F0344_RS22460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F0344_RS22475	COG2884	Cell division ATP-binding protein ftsE
F0344_RS22480	COG2177	Part of the ABC transporter FtsEX involved in
F0344_RS22485	COG0793	Belongs to the peptidase S41A family
F0344_RS22490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0344_RS22505	COG0583	DNA-binding transcription factor activity
F0344_RS22525	COG2223	nitrite transmembrane transporter activity
F0344_RS22560	COG3973	AAA domain
F0344_RS22560	COG3973	AAA domain
F0344_RS22570	COG0776	regulation of translation
F0344_RS22575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0344_RS22580	COG1678	Uncharacterized ACR, COG1678
F0344_RS22600	COG0395	ABC-type sugar transport system, permease component
F0344_RS22605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0344_RS22620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0344_RS22645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0344_RS22695	COG3654	unkown
F0344_RS22730	COG1732	Glycine betaine
F0344_RS22740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F0344_RS22750	COG0277	FAD linked oxidase domain protein
F0344_RS22785	COG1335	isochorismatase
F0344_RS22795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0344_RS22825	COG1234	tRNA 3'-trailer cleavage
F0344_RS22830	COG1263	PTS System
F0344_RS22835	COG1263	PTS System
F0344_RS22840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0344_RS22845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0344_RS22855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0344_RS22890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0344_RS22905	COG4555	ABC transporter
F0344_RS22920	COG2733	membrane
F0344_RS22935	COG1404	Belongs to the peptidase S8 family
F0344_RS23005	COG3764	Sortase (surface protein transpeptidase)
F0344_RS23030	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
F0344_RS23030	COG0706	membrane insertase activity
F0344_RS23040	COG4702	Belongs to the UPF0303 family
F0344_RS23045	COG0673	inositol 2-dehydrogenase activity
F0344_RS23060	COG2188	Transcriptional regulator
F0344_RS23065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0344_RS23155	COG3397	chitin binding
F0344_RS23170	COG1126	abc transporter atp-binding protein
F0344_RS23175	COG0765	amino acid transport
F0344_RS23180	COG0765	amino acid transport
F0344_RS23185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0344_RS23200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0344_RS23250	COG0406	alpha-ribazole phosphatase activity
F0344_RS23310	COG4977	sequence-specific DNA binding
F0344_RS23330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0344_RS23350	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F0344_RS23355	COG0076	glutamate decarboxylase activity
F0344_RS23375	COG1960	acyl-CoA dehydrogenase activity
F0344_RS23390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0344_RS23395	COG1309	transcriptional regulator
F0344_RS23405	COG1946	Acyl-CoA thioesterase
F0344_RS23460	COG0028	Belongs to the TPP enzyme family
F0344_RS23480	COG1472	Belongs to the glycosyl hydrolase 3 family
F0344_RS23490	COG0697	spore germination
F0344_RS23500	COG1609	Transcriptional regulator
F0344_RS23505	COG0673	inositol 2-dehydrogenase activity
F0344_RS23595	COG2409	Drug exporters of the RND superfamily
F0344_RS23625	COG3718	enzyme involved in inositol metabolism
F0344_RS23630	COG3962	Belongs to the TPP enzyme family
F0344_RS23665	COG0181	hydroxymethylbilane synthase activity
F0344_RS23690	COG1131	(ABC) transporter
F0344_RS23710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0344_RS23715	COG0640	Transcriptional regulator
F0344_RS23720	COG0798	PFAM Bile acid sodium symporter
F0344_RS23725	COG2072	flavoprotein involved in K transport
F0344_RS23735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0344_RS23750	COG3547	Transposase (IS116 IS110 IS902 family)
F0344_RS23810	COG0159	tryptophan synthase activity
F0344_RS24115	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0344_RS24275	COG0154	amidase activity
F0344_RS24285	COG0442	prolyl-tRNA aminoacylation
F0344_RS24300	COG2124	cytochrome p450
F0344_RS24320	COG4221	oxidoreductase activity
F0344_RS24320	COG3321	synthase
F0344_RS24320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS24320	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS24380	COG3387	PFAM Glycoside hydrolase 15-related
F0344_RS24400	COG2172	sigma factor antagonist activity
F0344_RS24480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0344_RS24485	COG0629	single-stranded DNA binding
F0344_RS24510	COG0577	efflux transmembrane transporter activity
F0344_RS24510	COG1136	(ABC) transporter
F0344_RS24525	COG2346	COG2346, Truncated hemoglobins
F0344_RS24535	COG1136	(ABC) transporter
F0344_RS24545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0344_RS24575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0344_RS24590	COG1486	melibiose metabolic process
F0344_RS24595	COG0395	ABC-type sugar transport system, permease component
F0344_RS24600	COG1175	transmembrane transport
F0344_RS24610	COG1940	carbohydrate kinase activity
F0344_RS24615	COG0668	transmembrane transport
F0344_RS24625	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0344_RS24625	COG3291	Pkd domain containing protein
F0344_RS24670	COG2337	Toxic component of a toxin-antitoxin (TA) module
F0344_RS24700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F0344_RS24715	COG0584	glycerophosphoryl diester phosphodiesterase
F0344_RS24720	COG1113	amino acid transport
F0344_RS24765	COG3594	Acyltransferase
F0344_RS24785	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0344_RS24790	COG0740	serine-type endopeptidase activity
F0344_RS24795	COG0740	serine-type endopeptidase activity
F0344_RS24800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0344_RS24805	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
F0344_RS24820	COG0525	valine-tRNA ligase activity
F0344_RS24825	COG0285	dihydrofolate synthase activity
F0344_RS24835	COG0105	UTP biosynthetic process
F0344_RS24840	COG1077	Cell shape determining protein MreB Mrl
F0344_RS24860	COG0772	Belongs to the SEDS family
F0344_RS24865	COG5607	PFAM CHAD domain containing protein
F0344_RS24865	COG3025	triphosphatase activity
F0344_RS24885	COG1530	ribonuclease E activity
F0344_RS24890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0344_RS24895	COG0673	inositol 2-dehydrogenase activity
F0344_RS24970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0344_RS24975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0344_RS24980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0344_RS25000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F0344_RS25005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0344_RS25015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0344_RS25030	COG0501	Belongs to the peptidase M48B family
F0344_RS25040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0344_RS25050	COG0799	negative regulation of ribosome biogenesis
F0344_RS25055	COG0588	phosphoglycerate mutase activity
F0344_RS25075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F0344_RS25085	COG0495	leucyl-tRNA aminoacylation
F0344_RS25095	COG1307	EDD domain protein, DegV family
F0344_RS25100	COG1555	photosystem II stabilization
F0344_RS25125	COG0268	Binds directly to 16S ribosomal RNA
F0344_RS25130	COG0481	GTPase activity
F0344_RS25160	COG1420	regulation of RNA biosynthetic process
F0344_RS25165	COG0484	heat shock protein binding
F0344_RS25185	COG0537	adenosine 5'-monophosphoramidase activity
F0344_RS25190	COG1234	tRNA 3'-trailer cleavage
F0344_RS25195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0344_RS25205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0344_RS25215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0344_RS25225	COG2315	Protein conserved in bacteria
F0344_RS25250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0344_RS25265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0344_RS25275	COG2409	Drug exporters of the RND superfamily
F0344_RS25280	COG4585	Histidine kinase
F0344_RS25285	COG2197	response regulator
F0344_RS25290	COG1381	Involved in DNA repair and RecF pathway recombination
F0344_RS25295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0344_RS25305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0344_RS25310	COG1121	(ABC) transporter
F0344_RS25315	COG3443	Belongs to the bacterial solute-binding protein 9 family
F0344_RS25315	COG0803	Belongs to the bacterial solute-binding protein 9 family
F0344_RS25320	COG0423	glycine-tRNA ligase activity
F0344_RS25340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0344_RS25340	COG0574	Belongs to the PEP-utilizing enzyme family
F0344_RS25365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0344_RS25365	COG2146	nitrite reductase [NAD(P)H] activity
F0344_RS25370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0344_RS25375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0344_RS25385	COG0667	Aldo Keto reductase
F0344_RS25435	COG1324	tolerance protein
F0344_RS25445	COG0243	molybdopterin cofactor binding
F0344_RS25455	COG2949	membrane
F0344_RS25465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0344_RS25475	COG0358	DNA primase activity
F0344_RS25480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0344_RS25495	COG1070	Carbohydrate kinase
F0344_RS25545	COG3483	tryptophan 2,3-dioxygenase activity
F0344_RS25555	COG1136	(ABC) transporter
F0344_RS25735	COG2188	Transcriptional regulator
F0344_RS25755	COG3842	ATPase activity
F0344_RS25785	COG1396	sequence-specific DNA binding
F0344_RS25835	COG2801	Transposase and inactivated derivatives
F0344_RS25870	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F0344_RS25895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS25905	COG2175	clavaminate synthase activity
F0344_RS25920	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F0344_RS25950	COG0154	amidase activity
F0344_RS25955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0344_RS25965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0344_RS26035	COG0515	serine threonine protein kinase
F0344_RS26040	COG0318	PFAM AMP-dependent synthetase and ligase
F0344_RS26050	COG1522	sequence-specific DNA binding
F0344_RS26080	COG2130	NADP-dependent
F0344_RS26085	COG4214	carbohydrate transport
F0344_RS26120	COG1280	lysine exporter protein (LysE YggA)
F0344_RS26125	COG1309	transcriptional regulator
F0344_RS26150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0344_RS26155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0344_RS26160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0344_RS26175	COG1741	Belongs to the pirin family
F0344_RS26205	COG2003	Belongs to the UPF0758 family
F0344_RS26230	COG0789	Transcriptional regulator
F0344_RS26235	COG0667	Aldo Keto reductase
F0344_RS26250	COG2197	response regulator
F0344_RS26270	COG1309	transcriptional regulator
F0344_RS26275	COG0477	Major facilitator Superfamily
F0344_RS26285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0344_RS26330	COG1358	cellular component organization or biogenesis
F0344_RS26365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0344_RS26485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0344_RS26505	COG3938	Belongs to the proline racemase family
F0344_RS26510	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS26515	COG1802	Transcriptional regulator
F0344_RS26525	COG2124	cytochrome p450
F0344_RS26530	COG0183	Belongs to the thiolase family
F0344_RS26560	COG2226	methyltransferase
F0344_RS26570	COG4981	capsule polysaccharide biosynthetic process
F0344_RS26605	COG3845	ABC transporter
F0344_RS26620	COG1657	PFAM Prenyltransferase squalene oxidase
F0344_RS26650	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS26670	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0344_RS26690	COG1309	transcriptional regulator
F0344_RS26695	COG0438	transferase activity, transferring glycosyl groups
F0344_RS26720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0344_RS26740	COG2814	Major facilitator Superfamily
F0344_RS26745	COG1960	acyl-CoA dehydrogenase activity
F0344_RS26750	COG0183	Belongs to the thiolase family
F0344_RS26760	COG2197	response regulator
F0344_RS26770	COG1131	(ABC) transporter
F0344_RS26775	COG2030	dehydratase
F0344_RS26785	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS26795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0344_RS26810	COG0800	Aldolase
F0344_RS26815	COG3022	response to hydroperoxide
F0344_RS26875	COG0673	inositol 2-dehydrogenase activity
F0344_RS26900	COG0384	phenazine biosynthesis protein PhzF
F0344_RS26905	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS26910	COG3540	Alkaline phosphatase
F0344_RS26920	COG2814	Major facilitator Superfamily
F0344_RS26950	COG0672	)-iron permease
F0344_RS26955	COG2837	iron assimilation
F0344_RS27005	COG1994	Peptidase M50
F0344_RS27020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0344_RS27030	COG2814	Major facilitator Superfamily
F0344_RS27035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0344_RS27035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0344_RS27040	COG2132	Multicopper oxidase
F0344_RS27065	COG0174	glutamine synthetase
F0344_RS27080	COG1011	Hydrolase
F0344_RS27135	COG2890	protein-(glutamine-N5) methyltransferase activity
F0344_RS27160	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0344_RS27170	COG1609	Transcriptional regulator
F0344_RS27175	COG2182	Extracellular solute-binding protein
F0344_RS27185	COG0395	ABC-type sugar transport system, permease component
F0344_RS27190	COG0366	Alpha amylase catalytic
F0344_RS27255	COG0745	RESPONSE REGULATOR receiver
F0344_RS27275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0344_RS27280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0344_RS27350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0344_RS27355	COG0321	lipoyl(octanoyl) transferase activity
F0344_RS27390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0344_RS27400	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0344_RS27405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0344_RS27410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0344_RS27420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0344_RS27430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0344_RS27465	COG4585	Histidine kinase
F0344_RS27470	COG2197	response regulator
F0344_RS27475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0344_RS27495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0344_RS27500	COG1104	cysteine desulfurase activity
F0344_RS27505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F0344_RS27510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0344_RS27520	COG1376	ErfK ybiS ycfS ynhG family protein
F0344_RS27530	COG1845	cytochrome c oxidase, subunit III
F0344_RS27535	COG2010	Cytochrome c
F0344_RS27540	COG0723	plastoquinol--plastocyanin reductase activity
F0344_RS27545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F0344_RS27550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0344_RS27555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0344_RS27600	COG0438	transferase activity, transferring glycosyl groups
F0344_RS27620	COG0003	Pfam Anion-transporting ATPase
F0344_RS27630	COG1940	carbohydrate kinase activity
F0344_RS27665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0344_RS27680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F0344_RS27690	COG2193	ferroxidase activity
F0344_RS27695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F0344_RS27705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0344_RS27710	COG2815	serine threonine protein kinase
F0344_RS27710	COG0515	serine threonine protein kinase
F0344_RS27715	COG2022	thiamine diphosphate biosynthetic process
F0344_RS27725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0344_RS27725	COG2022	thiamine diphosphate biosynthetic process
F0344_RS27740	COG0352	thiamine-phosphate diphosphorylase activity
F0344_RS27755	COG1233	COG1233 Phytoene dehydrogenase and related
F0344_RS27760	COG1309	transcriptional regulator
F0344_RS27780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0344_RS27800	COG0714	Associated with various cellular activities
F0344_RS27810	COG0275	rRNA processing
F0344_RS27820	COG0768	penicillin binding
F0344_RS27825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0344_RS27835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0344_RS27850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0344_RS27855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0344_RS27870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0344_RS27875	COG1799	cell septum assembly
F0344_RS27890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0344_RS27900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0344_RS27950	COG0587	DNA-directed DNA polymerase activity
F0344_RS27960	COG1432	Conserved Protein
F0344_RS27980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0344_RS28000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0344_RS28005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0344_RS28010	COG0131	Imidazoleglycerol-phosphate dehydratase
F0344_RS28020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0344_RS28025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0344_RS28030	COG0251	oxidation-reduction process
F0344_RS28035	COG0107	imidazoleglycerol-phosphate synthase activity
F0344_RS28050	COG2508	Transcriptional regulator
F0344_RS28065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0344_RS28070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0344_RS28090	COG0134	indole-3-glycerol-phosphate synthase activity
F0344_RS28100	COG0133	tryptophan synthase activity
F0344_RS28105	COG0159	tryptophan synthase activity
F0344_RS28115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0344_RS28125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0344_RS28130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0344_RS28160	COG0070	glutamate synthase
F0344_RS28160	COG0069	glutamate synthase activity
F0344_RS28160	COG0067	glutamate synthase
F0344_RS28170	COG0705	Rhomboid family
F0344_RS28190	COG1960	acyl-CoA dehydrogenase activity
F0344_RS28195	COG1960	acyl-CoA dehydrogenase activity
F0344_RS28200	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS28205	COG1309	transcriptional regulator
F0344_RS28210	COG0183	Belongs to the thiolase family
F0344_RS28215	COG1278	Cold shock
F0344_RS28240	COG1024	Enoyl-CoA hydratase
F0344_RS28245	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS28270	COG0287	Prephenate dehydrogenase
F0344_RS28270	COG1605	Chorismate mutase
F0344_RS28290	COG0737	Belongs to the 5'-nucleotidase family
F0344_RS28335	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0344_RS28345	COG2050	protein possibly involved in aromatic compounds catabolism
F0344_RS28380	COG1643	Atp-dependent helicase
F0344_RS28385	COG2226	methyltransferase
F0344_RS28400	COG0237	dephospho-CoA kinase activity
F0344_RS28440	COG0330	HflC and HflK could
F0344_RS28445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0344_RS28455	COG0436	Aminotransferase
F0344_RS28475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0344_RS28480	COG2313	pseudouridylate synthase activity
F0344_RS28490	COG0477	Major facilitator Superfamily
F0344_RS28495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0344_RS28500	COG0584	glycerophosphoryl diester phosphodiesterase
F0344_RS28510	COG0556	nucleotide-excision repair
F0344_RS28540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0344_RS28550	COG0322	excinuclease ABC activity
F0344_RS28555	COG1660	Displays ATPase and GTPase activities
F0344_RS28560	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0344_RS28565	COG1481	regulation of sporulation
F0344_RS28570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0344_RS28575	COG0126	phosphoglycerate kinase activity
F0344_RS28580	COG0149	triose-phosphate isomerase activity
F0344_RS28585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0344_RS28595	COG0166	Belongs to the GPI family
F0344_RS28615	COG0363	glucosamine-6-phosphate deaminase activity
F0344_RS28630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0344_RS28640	COG0109	protoheme IX farnesyltransferase activity
F0344_RS28670	COG4412	M6 family metalloprotease domain protein
F0344_RS28670	COG1404	Belongs to the peptidase S8 family
F0344_RS28685	COG0719	Fe-S assembly protein
F0344_RS28695	COG0396	ATPase activity
F0344_RS28700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0344_RS28705	COG0822	iron-sulfur transferase activity
F0344_RS28720	COG2171	N-acyltransferase activity
F0344_RS28765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0344_RS28770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0344_RS28785	COG1802	Transcriptional regulator
F0344_RS28790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0344_RS28800	COG1175	transmembrane transport
F0344_RS28805	COG0395	ABC-type sugar transport system, permease component
F0344_RS28835	COG1653	transport
F0344_RS28840	COG2755	lipolytic protein G-D-S-L family
F0344_RS28845	COG3866	Pectate lyase
F0344_RS28870	COG2252	PERMEase
F0344_RS28880	COG4585	Histidine kinase
F0344_RS28895	COG1414	Transcriptional regulator
F0344_RS28920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0344_RS28950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0344_RS28975	COG1797	cobyrinic acid a,c-diamide synthase activity
F0344_RS28995	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F0344_RS29010	COG0235	Class ii aldolase
F0344_RS29040	COG0488	(ABC) transporter
F0344_RS29050	COG1024	Enoyl-CoA hydratase
F0344_RS29090	COG3387	PFAM Glycoside hydrolase 15-related
F0344_RS29130	COG1404	Belongs to the peptidase S8 family
F0344_RS29140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0344_RS29145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0344_RS29160	COG2261	transglycosylase associated protein
F0344_RS29165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0344_RS29205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0344_RS29215	COG2186	Transcriptional regulator
F0344_RS29235	COG3830	Belongs to the UPF0237 family
F0344_RS29235	COG0560	Phosphoserine phosphatase
F0344_RS29245	COG1716	ATPase activity
F0344_RS29245	COG0842	Transport permease protein
F0344_RS29245	COG1131	(ABC) transporter
F0344_RS29260	COG4585	Histidine kinase
F0344_RS29265	COG2197	response regulator
F0344_RS29280	COG1119	ATPase activity
F0344_RS29305	COG1881	PFAM PEBP family protein
F0344_RS29315	COG2094	Belongs to the DNA glycosylase MPG family
F0344_RS29350	COG0647	UMP catabolic process
F0344_RS29355	COG1120	ATPase activity
F0344_RS29375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0344_RS29380	COG0497	DNA recombination
F0344_RS29395	COG3387	PFAM Glycoside hydrolase 15-related
F0344_RS29400	COG0504	CTP synthase activity
F0344_RS29405	COG0494	nUDIX hydrolase
F0344_RS29415	COG0686	Belongs to the AlaDH PNT family
F0344_RS29430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F0344_RS29435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F0344_RS29440	COG1187	pseudouridine synthase activity
F0344_RS29455	COG0494	nUDIX hydrolase
F0344_RS29485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0344_RS29495	COG1160	GTP binding
F0344_RS29515	COG0438	transferase activity, transferring glycosyl groups
F0344_RS29530	COG0671	phosphoesterase, PA-phosphatase related
F0344_RS29535	COG0477	Major facilitator Superfamily
F0344_RS29540	COG1960	acyl-CoA dehydrogenase activity
F0344_RS29545	COG1799	cell septum assembly
F0344_RS29590	COG1192	Involved in chromosome partitioning
F0344_RS29610	COG0714	Associated with various cellular activities
F0344_RS29620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0344_RS29635	COG0587	DNA-directed DNA polymerase activity
F0344_RS29640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0344_RS29670	COG1725	Transcriptional regulator
F0344_RS29680	COG2755	lipolytic protein G-D-S-L family
F0344_RS29685	COG0515	serine threonine protein kinase
F0344_RS29695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0344_RS29720	COG2188	Transcriptional regulator
F0344_RS29725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F0344_RS29745	COG1309	transcriptional regulator
F0344_RS29750	COG0243	molybdopterin cofactor binding
F0344_RS29760	COG3842	ATPase activity
F0344_RS29775	COG2326	polyphosphate kinase activity
F0344_RS29785	COG0640	Transcriptional regulator
F0344_RS29795	COG1960	acyl-CoA dehydrogenase activity
F0344_RS29825	COG3876	Protein conserved in bacteria
F0344_RS29835	COG0318	PFAM AMP-dependent synthetase and ligase
F0344_RS29845	COG2234	aminopeptidase activity
F0344_RS29845	COG4935	Belongs to the peptidase S8 family
F0344_RS29850	COG1960	acyl-CoA dehydrogenase activity
F0344_RS29860	COG4948	Mandelate Racemase Muconate Lactonizing
F0344_RS29875	COG2149	membrane
F0344_RS29880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0344_RS29910	COG3265	gluconokinase activity
F0344_RS29925	COG0531	amino acid
F0344_RS29945	COG0564	pseudouridine synthase activity
F0344_RS29970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0344_RS30000	COG0667	Aldo Keto reductase
F0344_RS30005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0344_RS30015	COG0598	Magnesium transport protein CorA
F0344_RS30035	COG0215	cysteine-tRNA ligase activity
F0344_RS30045	COG4948	Mandelate Racemase Muconate Lactonizing
F0344_RS30050	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS30055	COG2186	Transcriptional regulator
F0344_RS30060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0344_RS30065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0344_RS30070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0344_RS30075	COG1414	Transcriptional regulator
F0344_RS30080	COG0646	methionine synthase
F0344_RS30080	COG1410	methionine synthase
F0344_RS30095	COG2197	response regulator
F0344_RS30105	COG1994	Peptidase M50
F0344_RS30105	COG0517	IMP dehydrogenase activity
F0344_RS30125	COG1222	aaa ATPase
F0344_RS30130	COG4122	O-methyltransferase activity
F0344_RS30145	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F0344_RS30150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F0344_RS30155	COG1609	Transcriptional regulator
F0344_RS30165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F0344_RS30170	COG0545	Peptidyl-prolyl cis-trans isomerase
F0344_RS30180	COG2378	regulation of single-species biofilm formation
F0344_RS30200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0344_RS30205	COG0805	protein transport
F0344_RS30260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0344_RS30265	COG4175	Glycine betaine
F0344_RS30265	COG0517	IMP dehydrogenase activity
F0344_RS30270	COG4176	ABC-type proline glycine betaine transport system permease component
F0344_RS30290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F0344_RS30300	COG0174	glutamine synthetase
F0344_RS30305	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS30350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F0344_RS30355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0344_RS30360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0344_RS30365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0344_RS30370	COG5002	protein histidine kinase activity
F0344_RS30375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0344_RS30380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0344_RS30380	COG0072	phenylalanine-tRNA ligase activity
F0344_RS30440	COG3209	COG3209 Rhs family protein
F0344_RS30480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0344_RS30500	COG2197	response regulator
F0344_RS30520	COG4977	sequence-specific DNA binding
F0344_RS30525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0344_RS30530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F0344_RS30535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0344_RS30540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0344_RS30545	COG1438	arginine binding
F0344_RS30565	COG0137	argininosuccinate synthase activity
F0344_RS30570	COG0165	Argininosuccinate lyase
F0344_RS30590	COG0477	Major facilitator Superfamily
F0344_RS30600	COG0584	glycerophosphoryl diester phosphodiesterase
F0344_RS30630	COG2011	ABC-type metal ion transport system permease component
F0344_RS30635	COG1464	Belongs to the NlpA lipoprotein family
F0344_RS30650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0344_RS30655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0344_RS30655	COG1648	precorrin-2 dehydrogenase activity
F0344_RS30715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0344_RS30790	COG2176	DNA-directed DNA polymerase activity
F0344_RS30790	COG5002	protein histidine kinase activity
F0344_RS30805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0344_RS30810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0344_RS30830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0344_RS30835	COG1560	Kdo2-lipid A biosynthetic process
F0344_RS30840	COG0438	transferase activity, transferring glycosyl groups
F0344_RS30850	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F0344_RS30855	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F0344_RS30860	COG0217	transcriptional regulatory protein
F0344_RS30865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0344_RS30870	COG0632	four-way junction helicase activity
F0344_RS30875	COG2255	four-way junction helicase activity
F0344_RS30885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0344_RS30890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0344_RS30895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0344_RS30900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0344_RS30905	COG1196	nuclear chromosome segregation
F0344_RS30920	COG0124	histidyl-tRNA synthetase
F0344_RS30945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0344_RS30965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0344_RS30970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0344_RS30980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0344_RS30985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0344_RS30990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0344_RS30995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0344_RS31005	COG0006	proline dipeptidase activity
F0344_RS31010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0344_RS31015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0344_RS31025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F0344_RS31030	COG0540	Belongs to the ATCase OTCase family
F0344_RS31035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0344_RS31045	COG0505	Belongs to the CarA family
F0344_RS31050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0344_RS31055	COG0167	dihydroorotate dehydrogenase activity
F0344_RS31060	COG0284	orotidine-5'-phosphate decarboxylase activity
F0344_RS31075	COG1758	RNA polymerase activity
F0344_RS31085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0344_RS31100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0344_RS31110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0344_RS31115	COG2390	Transcriptional regulator
F0344_RS31120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0344_RS31130	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS31140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0344_RS31150	COG2233	PERMEase
F0344_RS31155	COG0738	Major facilitator superfamily
F0344_RS31160	COG1940	carbohydrate kinase activity
F0344_RS31160	COG1846	Transcriptional regulator
F0344_RS31180	COG3201	nicotinamide mononucleotide transporter
F0344_RS31185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0344_RS31185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0344_RS31190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0344_RS31195	COG0140	phosphoribosyl-ATP diphosphatase activity
F0344_RS31200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0344_RS31235	COG1960	acyl-CoA dehydrogenase activity
F0344_RS31250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0344_RS31255	COG1216	Glycosyl transferase, family 2
F0344_RS31270	COG2270	Major facilitator Superfamily
F0344_RS31280	COG2364	Membrane
F0344_RS31340	COG2018	Roadblock/LC7 domain
F0344_RS31355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0344_RS31370	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F0344_RS31385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0344_RS31395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0344_RS31400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0344_RS31400	COG2190	(PTS) system
F0344_RS31400	COG1263	PTS System
F0344_RS31425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0344_RS31445	COG1716	ATPase activity
F0344_RS31465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0344_RS31475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0344_RS31475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0344_RS31505	COG0384	phenazine biosynthesis protein PhzF
F0344_RS31550	COG0697	spore germination
F0344_RS31555	COG0583	DNA-binding transcription factor activity
F0344_RS31575	COG0789	Transcriptional regulator
F0344_RS31580	COG0659	secondary active sulfate transmembrane transporter activity
F0344_RS31610	COG0747	negative chemotaxis
F0344_RS31615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0344_RS31630	COG2318	DinB family
F0344_RS31645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F0344_RS31675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0344_RS31700	COG0277	FAD linked oxidase domain protein
F0344_RS31705	COG1968	undecaprenyl-diphosphatase activity
F0344_RS31770	COG0596	Alpha beta hydrolase
F0344_RS31780	COG1832	CoA-binding protein
F0344_RS31785	COG1739	Uncharacterized protein family UPF0029
F0344_RS31790	COG0420	3'-5' exonuclease activity
F0344_RS31795	COG0419	ATPase involved in DNA repair
F0344_RS31815	COG0626	cystathionine gamma-synthase activity
F0344_RS31835	COG2188	Transcriptional regulator
F0344_RS31840	COG1940	carbohydrate kinase activity
F0344_RS31845	COG2197	response regulator
F0344_RS31865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0344_RS31870	COG0590	tRNA wobble adenosine to inosine editing
F0344_RS31880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F0344_RS31930	COG2226	methyltransferase
F0344_RS31935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0344_RS31940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0344_RS31945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0344_RS31950	COG0156	8-amino-7-oxononanoate synthase activity
F0344_RS31965	COG0791	NLP P60 protein
F0344_RS31975	COG0740	serine-type endopeptidase activity
F0344_RS31990	COG0831	urea catabolic process
F0344_RS31995	COG0832	Belongs to the urease beta subunit family
F0344_RS32000	COG0804	urea catabolic process
F0344_RS32010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F0344_RS32015	COG0829	nickel cation binding
F0344_RS32025	COG0204	Acyl-transferase
F0344_RS32040	COG0205	6-phosphofructokinase activity
F0344_RS32045	COG3442	glutamine amidotransferase
F0344_RS32055	COG0242	peptide deformylase activity
F0344_RS32065	COG1960	acyl-CoA dehydrogenase activity
F0344_RS32070	COG0386	Belongs to the glutathione peroxidase family
F0344_RS32090	COG1946	Acyl-CoA thioesterase
F0344_RS32110	COG1793	dna ligase
F0344_RS32120	COG1132	(ABC) transporter
F0344_RS32130	COG1132	(ABC) transporter
F0344_RS32145	COG1132	(ABC) transporter
F0344_RS32150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0344_RS32155	COG2072	flavoprotein involved in K transport
F0344_RS32160	COG0432	Pfam Uncharacterised protein family UPF0047
F0344_RS32180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0344_RS32185	COG1653	transport
F0344_RS32190	COG1175	transmembrane transport
F0344_RS32195	COG0395	ABC-type sugar transport system, permease component
F0344_RS32220	COG2890	protein-(glutamine-N5) methyltransferase activity
F0344_RS32235	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS32255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0344_RS32255	COG0723	plastoquinol--plastocyanin reductase activity
F0344_RS32260	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS32300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0344_RS32315	COG1132	(ABC) transporter
F0344_RS32320	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F0344_RS32340	COG1470	cell adhesion involved in biofilm formation
F0344_RS32360	COG0515	serine threonine protein kinase
F0344_RS32360	COG2815	serine threonine protein kinase
F0344_RS32365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0344_RS32390	COG2706	6-phosphogluconolactonase activity
F0344_RS32405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0344_RS32420	COG1902	pentaerythritol trinitrate reductase activity
F0344_RS32425	COG2226	methyltransferase
F0344_RS32430	COG0640	Transcriptional regulator
F0344_RS32435	COG0493	'glutamate synthase
F0344_RS32465	COG0671	phosphoesterase, PA-phosphatase related
F0344_RS32485	COG0584	glycerophosphoryl diester phosphodiesterase
F0344_RS32505	COG0204	Acyl-transferase
F0344_RS32525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F0344_RS32550	COG1660	Displays ATPase and GTPase activities
F0344_RS32565	COG0492	ferredoxin-NADP+ reductase activity
F0344_RS32590	COG2223	nitrite transmembrane transporter activity
F0344_RS32635	COG1349	DNA-binding transcription factor activity
F0344_RS32670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0344_RS32725	COG1505	serine-type exopeptidase activity
F0344_RS32770	COG1404	Belongs to the peptidase S8 family
F0344_RS32780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0344_RS32785	COG0823	Involved in the tonB-independent uptake of proteins
F0344_RS32825	COG0513	Belongs to the DEAD box helicase family
F0344_RS32835	COG2124	cytochrome p450
F0344_RS32870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0344_RS32875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0344_RS32895	COG1115	amino acid carrier protein
F0344_RS32900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0344_RS32950	COG4044	May play a role in the intracellular transport of hydrophobic ligands
F0344_RS32980	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F0344_RS33010	COG1846	Transcriptional regulator
F0344_RS33015	COG1764	response to oxidative stress
F0344_RS33020	COG1796	DNA polymerase
F0344_RS33020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0344_RS33025	COG1132	(ABC) transporter
F0344_RS33040	COG0328	RNA-DNA hybrid ribonuclease activity
F0344_RS33080	COG0515	serine threonine protein kinase
F0344_RS33080	COG2815	serine threonine protein kinase
F0344_RS33090	COG1716	ATPase activity
F0344_RS33090	COG0842	Transport permease protein
F0344_RS33090	COG1131	(ABC) transporter
F0344_RS33130	COG0254	rRNA binding
F0344_RS33150	COG2084	Dehydrogenase
F0344_RS33155	COG1191	sigma factor activity
F0344_RS33175	COG0488	(ABC) transporter
F0344_RS33195	COG0515	serine threonine protein kinase
F0344_RS33205	COG1132	(ABC) transporter
F0344_RS33210	COG1132	(ABC) transporter
F0344_RS33215	COG2197	response regulator
F0344_RS33220	COG2217	Heavy metal translocating P-type atpase
F0344_RS33245	COG0501	Belongs to the peptidase M48B family
F0344_RS33275	COG2409	Drug exporters of the RND superfamily
F0344_RS33280	COG1846	Transcriptional regulator
F0344_RS33350	COG2365	Tyrosine phosphatase family
F0344_RS33405	COG1012	belongs to the aldehyde dehydrogenase family
F0344_RS33410	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F0344_RS33430	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F0344_RS33430	COG2066	Belongs to the glutaminase family
F0344_RS33435	COG2356	endonuclease I
F0344_RS33445	COG2813	Specifically methylates the guanine in position
F0344_RS33450	COG1960	acyl-CoA dehydrogenase activity
F0344_RS33465	COG2815	serine threonine protein kinase
F0344_RS33465	COG0515	serine threonine protein kinase
F0344_RS33495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0344_RS33500	COG2070	2-Nitropropane dioxygenase
F0344_RS33515	COG0318	PFAM AMP-dependent synthetase and ligase
F0344_RS33545	COG1024	Enoyl-CoA hydratase
F0344_RS33560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0344_RS33620	COG5297	Belongs to the glycosyl hydrolase family 6
F0344_RS33630	COG5297	Belongs to the glycosyl hydrolase family 6
F0344_RS33630	COG4733	cellulase activity
F0344_RS33650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0344_RS33720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0344_RS33730	COG1105	Belongs to the carbohydrate kinase PfkB family
F0344_RS33735	COG1349	DNA-binding transcription factor activity
F0344_RS33775	COG0702	epimerase
F0344_RS33825	COG1609	Transcriptional regulator
F0344_RS33845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F0344_RS33890	COG0395	ABC-type sugar transport system, permease component
F0344_RS33965	COG0739	heme binding
F0344_RS33970	COG2226	methyltransferase
F0344_RS34015	COG0464	growth
F0344_RS34020	COG1404	Belongs to the peptidase S8 family
F0344_RS34025	COG1674	ftsk spoiiie
F0344_RS34135	COG2770	Histidine kinase
F0344_RS34135	COG2208	phosphoserine phosphatase activity
F0344_RS34175	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS34215	COG0539	negative regulation of cytoplasmic translation
F0344_RS34240	COG0189	ligase activity
F0344_RS34330	COG0251	oxidation-reduction process
F0344_RS34340	COG2890	protein-(glutamine-N5) methyltransferase activity
F0344_RS34430	COG3046	protein related to deoxyribodipyrimidine photolyase
F0344_RS34435	COG1295	ribonuclease BN
F0344_RS34450	COG1475	DNA binding
F0344_RS34455	COG1192	Involved in chromosome partitioning
F0344_RS34560	COG1309	transcriptional regulator
F0344_RS34620	COG2207	Transcriptional regulator
F0344_RS34675	COG0300	oxidoreductase activity
F0344_RS34755	COG1309	transcriptional regulator
F0344_RS34770	COG2207	Transcriptional regulator
F0344_RS34770	COG0662	Cupin 2, conserved barrel domain protein
F0344_RS34805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0344_RS34830	COG0475	glutathione-regulated potassium exporter activity
F0344_RS34865	COG0477	Major facilitator Superfamily
F0344_RS34890	COG2124	cytochrome p450
F0344_RS34905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0344_RS34915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0344_RS34930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F0344_RS34940	COG0667	Aldo Keto reductase
F0344_RS34975	COG0277	FAD linked oxidase domain protein
F0344_RS34990	COG2226	methyltransferase
F0344_RS35015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0344_RS35035	COG2378	regulation of single-species biofilm formation
F0344_RS35040	COG1028	Short-chain dehydrogenase reductase Sdr
F0344_RS35050	COG1595	DNA-templated transcription, initiation
F0344_RS35065	COG2843	Capsule synthesis protein