locus-tag class description BFF78_RS00075 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BFF78_RS00080 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BFF78_RS00090 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BFF78_RS00110 ENOG4105C57 major facilitator superfamily BFF78_RS00190 ENOG4107SVN transposase BFF78_RS00195 ENOG4105D5G Transposase BFF78_RS00215 ENOG4105BZP glycoside hydrolase 15-related BFF78_RS00240 ENOG4107S5I aldo keto reductase BFF78_RS00270 ENOG4108762 serine threonine protein kinase BFF78_RS00275 ENOG4108SGK Tetr family transcriptional regulator BFF78_RS00345 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BFF78_RS00355 ENOG4105D5G Transposase BFF78_RS00430 ENOG4105CPQ Dehydrogenase BFF78_RS00445 ENOG4107RA9 decarboxylase BFF78_RS00520 ENOG4107SCK Monooxygenase BFF78_RS00610 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BFF78_RS00665 ENOG4105DFU Cell wall formation (By similarity) BFF78_RS00710 ENOG4105DFW ABC transporter BFF78_RS00715 ENOG4105C2J ABC transporter BFF78_RS00720 ENOG4108HWW ABC transporter BFF78_RS00740 ENOG4105CSU acyl-Coa dehydrogenase BFF78_RS00790 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS00975 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) BFF78_RS01020 ENOG4105CIR epoxide hydrolase BFF78_RS01035 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS01090 ENOG41068WN BFF78_RS01100 ENOG4106A3M Cytochrome p-450 BFF78_RS01105 ENOG4105D5G Transposase BFF78_RS01170 ENOG4108WKN secreted protein BFF78_RS01190 ENOG410836F Transposase BFF78_RS01195 ENOG410836F Transposase BFF78_RS01230 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 BFF78_RS01285 ENOG4107QTZ amino acid BFF78_RS01320 ENOG4106UDK Cellulose-binding, family II BFF78_RS01330 ENOG4105XEA Tetr family transcriptional regulator BFF78_RS01340 ENOG4107MII Sugar-specific transcriptional regulator TrmB BFF78_RS01345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BFF78_RS01350 ENOG4108JGH Tetr family transcriptional regulator BFF78_RS01355 ENOG4105CPQ Dehydrogenase BFF78_RS01430 ENOG4107SET aldo keto reductase BFF78_RS01540 ENOG4105CHR reductase BFF78_RS01555 ENOG4105DBV ornithine carbamoyltransferase BFF78_RS01570 ENOG4105ECQ AraC Family Transcriptional Regulator BFF78_RS01585 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BFF78_RS01590 ENOG4105CIH Imidazole acetol-phosphate transaminase BFF78_RS01625 ENOG4105CJW magnesium transporter BFF78_RS01680 ENOG4106NZI LysR family Transcriptional regulator BFF78_RS01710 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS01715 ENOG4108JPZ Monovalent cation H antiporter subunit D BFF78_RS01725 ENOG4107TDF Formate hydrogenlyase subunit 4 BFF78_RS01735 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit BFF78_RS01750 ENOG4105CHH sulfate transporter BFF78_RS01755 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BFF78_RS01760 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BFF78_RS01770 ENOG4105E39 Enoyl-CoA hydratase BFF78_RS01785 ENOG4105EA8 2-Nitropropane dioxygenase BFF78_RS01790 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BFF78_RS01800 ENOG4105NRA 50s ribosomal protein l31 type b BFF78_RS01810 ENOG4105KDC 50s ribosomal protein l28 BFF78_RS01815 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BFF78_RS01835 ENOG4105F2C Acetyl-CoA acetyltransferase BFF78_RS01840 ENOG4108RZE Tetr family transcriptional regulator BFF78_RS01845 ENOG4105CHR reductase BFF78_RS01855 ENOG4105CC9 acyl-Coa dehydrogenase BFF78_RS01865 ENOG4107QN2 dihydrolipoyl dehydrogenase BFF78_RS01910 ENOG4108HMN Caspase domain BFF78_RS01970 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) BFF78_RS01995 ENOG4107Y2X deaminase BFF78_RS02010 ENOG4105CPF Cell wall formation (By similarity) BFF78_RS02015 ENOG4105CPF Cell wall formation (By similarity) BFF78_RS02020 ENOG4108VCT Sulfite exporter TauE/SafE BFF78_RS02030 ENOG4107TPS domain protein BFF78_RS02035 ENOG4105FDP GntR family transcriptional regulator BFF78_RS02055 ENOG4108X7A Terpene synthase metal-binding domain-containing protein BFF78_RS02120 ENOG4108M4U conserved membrane protein BFF78_RS02135 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BFF78_RS02140 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS02145 ENOG4108V1U phospholipid-binding protein BFF78_RS02165 ENOG41080XP Cbs domain BFF78_RS02180 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) BFF78_RS02285 ENOG4105CFG Acts as a chaperone (By similarity) BFF78_RS02290 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BFF78_RS02320 ENOG4105C75 arginyL-tRNA synthetase BFF78_RS02330 ENOG4108SGR YheO domain-containing protein BFF78_RS02335 ENOG4105D29 Helix-turn-helix type 11 domain protein BFF78_RS02345 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BFF78_RS02385 ENOG4105ETS cytosine purines uracil thiamine allantoin BFF78_RS02405 ENOG4105CJ1 ABC, transporter BFF78_RS02410 ENOG4105BZU Histidine kinase BFF78_RS02415 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS02450 ENOG4105ECQ AraC Family Transcriptional Regulator BFF78_RS02455 ENOG4105CDH Citrulline--aspartate ligase BFF78_RS02555 ENOG4105F6U Short-chain dehydrogenase reductase Sdr BFF78_RS02575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BFF78_RS02580 ENOG4105DND Transcriptional regulator BFF78_RS02600 ENOG4107TE5 Lipid kinase BFF78_RS02605 ENOG4107R3A FAD linked oxidase domain protein BFF78_RS02640 ENOG4105CHR reductase BFF78_RS02645 ENOG4105C5H ABC transporter BFF78_RS02670 ENOG4105C2W permease BFF78_RS02675 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BFF78_RS02695 ENOG4105CN1 protease BFF78_RS02705 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BFF78_RS02730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS02735 ENOG4107TYH extracellular solute-binding protein family 1 BFF78_RS02740 ENOG4105D81 ABC transporter, permease BFF78_RS02745 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component BFF78_RS02760 ENOG4108NNZ chitinase BFF78_RS02770 ENOG4108IG5 Transcriptional regulator BFF78_RS02795 ENOG4107RSM transcriptional regulator BFF78_RS02800 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS02805 ENOG4105CPC Aldo Keto reductase BFF78_RS02825 ENOG4107QTZ amino acid BFF78_RS02835 ENOG4105CWX Alpha-1,2-mannosidase BFF78_RS02860 ENOG4106R7G Glycoside hydrolase family 5 BFF78_RS02870 ENOG4108IXY short-chain dehydrogenase reductase BFF78_RS02905 ENOG4105DBE peroxidase BFF78_RS02945 ENOG4108KB2 LysR family Transcriptional regulator BFF78_RS02990 ENOG4105FDF Could be involved in DNA repair (By similarity) BFF78_RS03010 ENOG4105CXN decarboxylase BFF78_RS03025 ENOG4105EGE secreted protein BFF78_RS03035 ENOG4105ERR inositol mono-phosphatase BFF78_RS03105 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr BFF78_RS03115 ENOG4106UDK Cellulose-binding, family II BFF78_RS03130 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BFF78_RS03140 ENOG4107SET aldo keto reductase BFF78_RS03260 ENOG4108N5B 2-phosphosulfolactate phosphatase BFF78_RS03270 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BFF78_RS03285 ENOG4105BZP glycoside hydrolase 15-related BFF78_RS03310 ENOG4105D9G High-affinity BFF78_RS03325 ENOG4105DQR SNARE associated Golgi BFF78_RS03330 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BFF78_RS03335 ENOG410841Q phosphoesterase PA-phosphatase related protein BFF78_RS03345 ENOG4106F60 Histidine kinase BFF78_RS03385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS03420 ENOG4107SGM protein serine threonine phosphatase BFF78_RS03465 ENOG4105C87 Aminotransferase class I and II BFF78_RS03505 ENOG4105DND Transcriptional regulator BFF78_RS03515 ENOG4108R85 Short chain dehydrogenase BFF78_RS03520 ENOG4105CHR reductase BFF78_RS03525 ENOG4105C5X domain protein BFF78_RS03565 ENOG4105BZ9 Cytochrome C oxidase, subunit I BFF78_RS03625 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family BFF78_RS03645 ENOG4108W6C Dehydrogenase BFF78_RS03650 ENOG4105CXK mandelate racemase muconate lactonizing BFF78_RS03665 ENOG41080V3 Major Facilitator superfamily BFF78_RS03670 ENOG4105D3W isochorismatase BFF78_RS03675 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BFF78_RS03690 ENOG4105BZ9 Cytochrome C oxidase, subunit I BFF78_RS03700 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BFF78_RS03715 ENOG4105CJA serine threonine protein kinase BFF78_RS03765 ENOG4108JJA ABC, transporter BFF78_RS03770 ENOG4108JJA ABC, transporter BFF78_RS03795 ENOG4105EMU Dehydrogenase BFF78_RS03820 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BFF78_RS03865 ENOG4105CNT hydrolase family 2 BFF78_RS03875 ENOG4105DU6 RNA polymerase BFF78_RS03880 ENOG4108V5V Serine Threonine protein kinase BFF78_RS03915 ENOG4105CPC Aldo Keto reductase BFF78_RS03950 ENOG4106YKD Cytochrome p-450 BFF78_RS03970 ENOG4105CHF Glutathione S-transferase BFF78_RS03990 ENOG4105CUB amino acid BFF78_RS04000 ENOG4105ECQ AraC Family Transcriptional Regulator BFF78_RS04010 ENOG4105WN5 stage II sporulation protein BFF78_RS04015 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BFF78_RS04020 ENOG4105EDW glycosyl transferase, family 39 BFF78_RS04025 ENOG4105C8S subunit m BFF78_RS04030 ENOG4105MKQ Monovalent cation H antiporter subunit C BFF78_RS04070 ENOG4105DCG PHP domain protein BFF78_RS04075 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BFF78_RS04095 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BFF78_RS04130 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BFF78_RS04140 ENOG4108R86 Transcriptional regulator BFF78_RS04145 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BFF78_RS04150 ENOG4105DDN Pentapeptide repeat-containing protein BFF78_RS04170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BFF78_RS04175 ENOG4107QR9 Iron-sulfur cluster binding protein BFF78_RS04180 ENOG41080R8 Conserved Protein BFF78_RS04190 ENOG4108IJ8 ABC transporter BFF78_RS04200 ENOG4105E90 ABC transporter BFF78_RS04205 ENOG4105E90 ABC transporter BFF78_RS04215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BFF78_RS04235 ENOG4105D9U N-acetyltransferase BFF78_RS04250 ENOG410836F Transposase BFF78_RS04255 ENOG4105EUB pirin domain protein BFF78_RS04270 ENOG41075H3 AraC family transcriptional regulator BFF78_RS04275 ENOG4105CBG Sulfatase BFF78_RS04320 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) BFF78_RS04405 ENOG4105ENX hydrolase BFF78_RS04420 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BFF78_RS04440 ENOG4105E2Y ABC, transporter BFF78_RS04460 ENOG4105CSR polyphosphate kinase 2 BFF78_RS04520 ENOG4106YKD Cytochrome p-450 BFF78_RS04610 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BFF78_RS04630 ENOG41080RH Thioredoxin BFF78_RS04640 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS04650 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BFF78_RS04715 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process BFF78_RS04720 ENOG4108V75 Glutamine amidotransferase BFF78_RS04725 ENOG41067HS methyltransferase BFF78_RS04730 ENOG4105C9Q fumarate hydratase class II BFF78_RS04775 ENOG4105WKW Pfam:DUF1458 BFF78_RS04785 ENOG4105DEN Luciferase family BFF78_RS04810 ENOG4105E33 succinate dehydrogenase BFF78_RS04825 ENOG4105C5Q Transcriptional regulator BFF78_RS04830 ENOG4105D9P serine threonine protein kinase BFF78_RS04835 ENOG4105BZU Histidine kinase BFF78_RS04870 ENOG4108ZJ4 polysaccharide deacetylase BFF78_RS04880 ENOG4105CRK lysyL-tRNA synthetase BFF78_RS04895 ENOG4108MP6 LysR family Transcriptional regulator BFF78_RS04900 ENOG4105CUB amino acid BFF78_RS04965 ENOG4105CHR reductase BFF78_RS04970 ENOG4105DIA mandelate racemase muconate lactonizing BFF78_RS04980 ENOG4105C2J ABC transporter BFF78_RS04985 ENOG4105DFW ABC transporter BFF78_RS05020 ENOG4105BZ7 extracellular solute-binding protein family 1 BFF78_RS05025 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS05060 ENOG4105CWX Alpha-1,2-mannosidase BFF78_RS05070 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BFF78_RS05075 ENOG4107QPH glycogen) synthase BFF78_RS05095 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BFF78_RS05100 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BFF78_RS05110 ENOG4107GJV short-chain dehydrogenase reductase BFF78_RS05130 ENOG4105EX0 alpha-galactosidase BFF78_RS05140 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BFF78_RS05145 ENOG4108JP0 extracellular solute-binding protein family 1 BFF78_RS05185 ENOG4105C26 Dehydrogenase BFF78_RS05255 ENOG4105E2R ROK family BFF78_RS05260 ENOG4105C2J ABC transporter BFF78_RS05265 ENOG4105CNN ABC, transporter BFF78_RS05270 ENOG4105DFW ABC transporter BFF78_RS05295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BFF78_RS05310 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS05350 ENOG4105VN1 Heat shock protein BFF78_RS05365 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BFF78_RS05375 ENOG4105DVC DnaJ domain protein BFF78_RS05380 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BFF78_RS05385 ENOG4105CFG Acts as a chaperone (By similarity) BFF78_RS05390 ENOG4107VHA regulatoR BFF78_RS05405 ENOG4105E2A Dehydrogenase BFF78_RS05420 ENOG4105CK7 Sodium proline symporter BFF78_RS05450 ENOG4107RN3 metallophosphoesterase BFF78_RS05465 ENOG4106NZI LysR family Transcriptional regulator BFF78_RS05470 ENOG4105CJN penicillin-binding protein BFF78_RS05480 ENOG4105CHR reductase BFF78_RS05490 ENOG4105EBR Carboxylesterase BFF78_RS05535 ENOG4105DRR Transcriptional regulator, GntR family BFF78_RS05540 ENOG4105C26 Dehydrogenase BFF78_RS05545 ENOG4108KXM LysR family Transcriptional regulator BFF78_RS05560 ENOG4108JQ7 (ABC) transporter BFF78_RS05565 ENOG4105C3U ABC transporter BFF78_RS05575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BFF78_RS05580 ENOG4105DEF Extracellular solute-binding protein, family 5 BFF78_RS05595 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS05605 ENOG4105CMG Carbohydrate kinase BFF78_RS05680 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) BFF78_RS05745 ENOG4108NEV two component transcriptional regulator, LytTR family BFF78_RS05760 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding BFF78_RS05765 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit BFF78_RS05770 ENOG4105EGE secreted protein BFF78_RS05775 ENOG4106UDK Cellulose-binding, family II BFF78_RS05785 ENOG4105BZ1 (ABC) transporter BFF78_RS05795 ENOG4105E39 Enoyl-CoA hydratase BFF78_RS05805 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BFF78_RS05810 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BFF78_RS05820 ENOG4105CUB amino acid BFF78_RS05825 ENOG4105D64 Mechanosensitive ion channel BFF78_RS05830 ENOG4105M0C cytoplasmic protein BFF78_RS05835 ENOG4105E9K Isocitrate dehydrogenase BFF78_RS05845 ENOG4106A3M Cytochrome p-450 BFF78_RS05860 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin BFF78_RS05870 ENOG4106S2D Transcriptional regulator BFF78_RS05890 ENOG410836F Transposase BFF78_RS05910 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BFF78_RS05915 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BFF78_RS05920 ENOG4105CTU Proline racemase BFF78_RS05930 ENOG4105D5Q Arginine ornithine antiporter BFF78_RS05935 ENOG4105EBR Carboxylesterase BFF78_RS05940 ENOG4106YYS transcriptional regulatory protein BFF78_RS05955 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BFF78_RS05990 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS05995 ENOG41089GP Oxidoreductase domain protein BFF78_RS06005 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS06015 ENOG4105CHR reductase BFF78_RS06035 ENOG4105C2J ABC transporter BFF78_RS06040 ENOG4105CNN ABC, transporter BFF78_RS06050 ENOG4105FDP GntR family transcriptional regulator BFF78_RS06100 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS06105 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS06110 ENOG4105E5G Alpha beta hydrolase fold BFF78_RS06135 ENOG4105BZU Histidine kinase BFF78_RS06145 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS06150 ENOG410667J hydrolase BFF78_RS06160 ENOG4105C5F glutamine synthetase BFF78_RS06215 ENOG4106NZI LysR family Transcriptional regulator BFF78_RS06220 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BFF78_RS06225 ENOG4105CPQ Dehydrogenase BFF78_RS06255 ENOG4105F9N Major Facilitator Superfamily BFF78_RS06275 ENOG4105D9P serine threonine protein kinase BFF78_RS06290 ENOG4108YYH Nadph-dependent fmn reductase BFF78_RS06350 ENOG4105EMU Dehydrogenase BFF78_RS06360 ENOG4105D82 Glutamate dehydrogenase BFF78_RS06370 ENOG41090WU lipolytic protein G-D-S-L family BFF78_RS06405 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BFF78_RS06420 ENOG4105EWU Squalene--hopene cyclase BFF78_RS06445 ENOG4105EY8 ABC transporter BFF78_RS06465 ENOG4108MDK Dehydrogenase BFF78_RS06485 ENOG4105PGM cation diffusion facilitator family transporter BFF78_RS06490 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BFF78_RS06505 ENOG4105E39 Enoyl-CoA hydratase BFF78_RS06520 ENOG4105BZM domain protein BFF78_RS06525 ENOG4105C5H ABC transporter BFF78_RS06550 ENOG4108U3T pfkb domain protein BFF78_RS06570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BFF78_RS06575 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS06580 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BFF78_RS06585 ENOG4105EG6 Saccharopine dehydrogenase BFF78_RS06595 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BFF78_RS06615 ENOG4105KF0 sporulation and cell division protein, SsgA BFF78_RS06630 ENOG4105C5H ABC transporter BFF78_RS06635 ENOG4106V2I dimethylaminohydrolase BFF78_RS06645 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BFF78_RS06670 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS06685 ENOG4105DQE DNA ligase BFF78_RS06720 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha BFF78_RS06725 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BFF78_RS06730 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BFF78_RS06740 ENOG4107SM8 Adenylate Guanylate cyclase BFF78_RS06785 ENOG4105CG3 alpha amylase, catalytic region BFF78_RS06795 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BFF78_RS06845 ENOG4106UDK Cellulose-binding, family II BFF78_RS06855 ENOG4105F8D glycoside hydrolase family 4 BFF78_RS06865 ENOG41088CQ domain protein BFF78_RS06890 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BFF78_RS06905 ENOG4107QP8 phosphohexose isomerase BFF78_RS06910 ENOG4108J5G 6-phosphogluconate dehydrogenase BFF78_RS06920 ENOG4105EDW glycosyl transferase, family 39 BFF78_RS06935 ENOG41086KC Transcriptional regulator BFF78_RS06980 ENOG410905P Pyridoxamine 5-phosphate BFF78_RS07000 ENOG4107QJN gtp cyclohydrolase ii BFF78_RS07015 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BFF78_RS07075 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BFF78_RS07090 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BFF78_RS07100 ENOG4106A3M Cytochrome p-450 BFF78_RS07160 ENOG4108JA1 polyketide synthase BFF78_RS07200 ENOG4105D5P Methylmalonyl-coA mutase BFF78_RS07205 ENOG4108WF3 methyltransferase BFF78_RS07215 ENOG4105K8R UPF0145 protein BFF78_RS07225 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS07275 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BFF78_RS07305 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BFF78_RS07320 ENOG4105EMU Dehydrogenase BFF78_RS07330 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BFF78_RS07335 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BFF78_RS07350 ENOG4107SJB teichoic acid biosynthesis BFF78_RS07375 ENOG4105FE1 phytoene synthase BFF78_RS07395 ENOG4105CBC glutamate synthase BFF78_RS07405 ENOG4105D9P serine threonine protein kinase BFF78_RS07470 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS07500 ENOG4107U9T Pfam:Ribonuclease_BN BFF78_RS07530 ENOG41064MX Tetr family transcriptional regulator BFF78_RS07535 ENOG4107S5I aldo keto reductase BFF78_RS07550 ENOG4108FKE two-component system sensor kinase BFF78_RS07570 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BFF78_RS07575 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS07585 ENOG4105EB3 Histidine kinase BFF78_RS07610 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BFF78_RS07630 ENOG4105VEQ Cold shock protein BFF78_RS07665 ENOG4105CNI cell division protein FtsW BFF78_RS07670 ENOG41082SX arsR family transcriptional regulator BFF78_RS07720 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BFF78_RS07730 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BFF78_RS07735 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BFF78_RS07740 ENOG41082SX arsR family transcriptional regulator BFF78_RS07835 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BFF78_RS07840 ENOG4105FUA antagonist BFF78_RS07845 ENOG4107MMM Anti-sigma-factor antagonist BFF78_RS07870 ENOG4105IDI abc transporter atp-binding protein BFF78_RS07940 ENOG4105D5G Transposase BFF78_RS07965 ENOG4107SVN transposase BFF78_RS07990 ENOG4108NV9 Glycosyl Transferase BFF78_RS07995 ENOG4107QQG Dehydrogenase BFF78_RS08015 ENOG4107SVN transposase BFF78_RS08090 ENOG4106A3M Cytochrome p-450 BFF78_RS08155 ENOG4105K4H Nlp p60 protein BFF78_RS08215 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BFF78_RS08360 ENOG41061GT Aldolase BFF78_RS08405 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS08450 ENOG4105CVR type I restriction-modification system BFF78_RS08460 ENOG4108I5C dEAD DEAH box helicase BFF78_RS08465 ENOG4105D9P serine threonine protein kinase BFF78_RS08475 ENOG4105D9P serine threonine protein kinase BFF78_RS08600 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BFF78_RS08605 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BFF78_RS08610 ENOG4106NZI LysR family Transcriptional regulator BFF78_RS08620 ENOG4105D3W isochorismatase BFF78_RS08625 ENOG4108VHT MarR family transcriptional regulator BFF78_RS08635 ENOG4108478 ec 3.2.1.18 BFF78_RS08640 ENOG4105DHU Bile acid BFF78_RS08645 ENOG4105DUM transcriptional regulator, lysR family BFF78_RS08670 ENOG4105F5H Glycosyl Hydrolase Family 88 BFF78_RS08685 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) BFF78_RS08690 ENOG4105CV8 reductase BFF78_RS08710 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS08720 ENOG4105FBN Acid phosphatase BFF78_RS08725 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BFF78_RS08730 ENOG4106GCT Dehydratase BFF78_RS08755 ENOG4105CFG Acts as a chaperone (By similarity) BFF78_RS08825 ENOG4108Z0Z intracellular protease Pfpi family BFF78_RS08840 ENOG4105C5H ABC transporter BFF78_RS08850 ENOG4105GCF PGAM BFF78_RS08860 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS08875 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BFF78_RS08885 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BFF78_RS08910 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BFF78_RS08965 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BFF78_RS08975 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BFF78_RS08980 ENOG4108ME1 Peptidase M55 D-aminopeptidase BFF78_RS08985 ENOG4105C9B Cysteine desulfurase BFF78_RS08990 ENOG4105ESN nucleotide-binding protein BFF78_RS08990 ENOG4105ESN nucleotide-binding protein BFF78_RS09010 ENOG4108Q50 Histidine kinase BFF78_RS09040 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BFF78_RS09050 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BFF78_RS09070 ENOG4105CI0 Citrate lyase BFF78_RS09080 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS09085 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme BFF78_RS09100 ENOG4105BZW Glycerate kinase BFF78_RS09120 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BFF78_RS09155 ENOG4105DAE Methylenetetrahydrofolate reductase BFF78_RS09185 ENOG4105ECY inositol monophosphatase BFF78_RS09210 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BFF78_RS09220 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BFF78_RS09235 ENOG4105C8Y Acetylornithine aminotransferase BFF78_RS09260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BFF78_RS09265 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BFF78_RS09300 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BFF78_RS09335 ENOG4105VBF alkaline shock protein BFF78_RS09370 ENOG4105EPW hflc protein BFF78_RS09375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BFF78_RS09450 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BFF78_RS09455 ENOG4105CPQ Dehydrogenase BFF78_RS09485 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase BFF78_RS09490 ENOG4105ERH Fumarylacetoacetate hydrolase BFF78_RS09510 ENOG4105WN5 stage II sporulation protein BFF78_RS09525 ENOG4105EN6 Membrane BFF78_RS09530 ENOG4105CH2 amidohydrolase BFF78_RS09585 ENOG4105VBF alkaline shock protein BFF78_RS09675 ENOG4105D8K carboxyl transferase BFF78_RS09690 ENOG4105EYF MMPL domain protein BFF78_RS09715 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BFF78_RS09730 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS09745 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS09750 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS09765 ENOG4105CHR reductase BFF78_RS09770 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BFF78_RS09775 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BFF78_RS09820 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BFF78_RS09825 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BFF78_RS09845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BFF78_RS09860 ENOG4105C0W non-ribosomal peptide synthetase BFF78_RS09890 ENOG4105C0D helicase BFF78_RS09900 ENOG4105DKQ ROK family BFF78_RS09905 ENOG4105C2J ABC transporter BFF78_RS09910 ENOG41062B0 ABC transporter, permease BFF78_RS09925 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BFF78_RS09935 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS09955 ENOG4105CTB Polyprenyl synthetase BFF78_RS09995 ENOG4105DHG Allantoate amidinohydrolase BFF78_RS10005 ENOG4107HP6 Transcriptional regulator BFF78_RS10015 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BFF78_RS10020 ENOG4107R9S Malate synthase BFF78_RS10030 ENOG4108HRK Histidine kinase BFF78_RS10035 ENOG4105K4I Scp-like extracellular BFF78_RS10045 ENOG4105DUU IucA IucC family protein BFF78_RS10065 ENOG4105CHM Aminotransferase BFF78_RS10080 ENOG4108ZM9 phosphoglycerate mutase BFF78_RS10100 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BFF78_RS10115 ENOG4105VT2 5-hydroxyisourate hydrolase BFF78_RS10150 ENOG4105CY3 ABC transporter, permease BFF78_RS10200 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BFF78_RS10205 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BFF78_RS10210 ENOG4105CH6 catalase BFF78_RS10220 ENOG41060W2 glyoxylate carboligase BFF78_RS10235 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS10240 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BFF78_RS10255 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap BFF78_RS10265 ENOG4107QUT magnesium and cobalt transport protein CorA BFF78_RS10275 ENOG4108ZJ4 polysaccharide deacetylase BFF78_RS10285 ENOG410829K Lysine exporter protein (Lyse ygga) BFF78_RS10295 ENOG4105C7N Xanthine uracil vitamin C permease BFF78_RS10300 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BFF78_RS10330 ENOG4105DRR Transcriptional regulator, GntR family BFF78_RS10345 ENOG4105C7K acetolactate synthase BFF78_RS10370 ENOG4106HB6 Alpha beta hydrolase BFF78_RS10380 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BFF78_RS10395 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BFF78_RS10400 ENOG4105VEQ Cold shock protein BFF78_RS10405 ENOG4105C1J atp-dependent rna helicase BFF78_RS10410 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) BFF78_RS10430 ENOG4105E2R ROK family BFF78_RS10450 ENOG4108VQT Alpha beta hydrolase fold protein BFF78_RS10470 ENOG4105EBR Carboxylesterase BFF78_RS10505 ENOG4105CSU acyl-Coa dehydrogenase BFF78_RS10510 ENOG4107RR1 TRANSCRIPTIONal BFF78_RS10535 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BFF78_RS10560 ENOG4108IY8 ABC, transporter BFF78_RS10565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BFF78_RS10580 ENOG4105MC2 DSBA oxidoreductase BFF78_RS10595 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BFF78_RS10650 ENOG4105DND Transcriptional regulator BFF78_RS10665 ENOG4105ZSU inhibitor BFF78_RS10705 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BFF78_RS10710 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein BFF78_RS10720 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BFF78_RS10735 ENOG41064MX Tetr family transcriptional regulator BFF78_RS10770 ENOG41082SX arsR family transcriptional regulator BFF78_RS10800 ENOG4108HQR Glycine betaine BFF78_RS10805 ENOG4105E90 ABC transporter BFF78_RS10810 ENOG4105E90 ABC transporter BFF78_RS10840 ENOG4105E0X reductase BFF78_RS10845 ENOG4105DFU Cell wall formation (By similarity) BFF78_RS10870 ENOG4107B2H carbonic anhydrase BFF78_RS10885 ENOG4108V1U phospholipid-binding protein BFF78_RS10890 ENOG4105CSR polyphosphate kinase 2 BFF78_RS10910 ENOG4108IUX (ABC) transporter BFF78_RS10930 ENOG4105E18 UPF0276 protein BFF78_RS10950 ENOG4107JTW chlorite dismutase BFF78_RS10965 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BFF78_RS10980 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BFF78_RS11000 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS11005 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BFF78_RS11040 ENOG4105CUB amino acid BFF78_RS11045 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BFF78_RS11050 ENOG4108HWW ABC transporter BFF78_RS11055 ENOG4105C2J ABC transporter BFF78_RS11060 ENOG4105DFW ABC transporter BFF78_RS11065 ENOG4105E2R ROK family BFF78_RS11090 ENOG4105CWX Alpha-1,2-mannosidase BFF78_RS11095 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BFF78_RS11105 ENOG4107QM5 aconitate hydratase BFF78_RS11110 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BFF78_RS11125 ENOG4105JKW Valine--pyruvate aminotransferase BFF78_RS11170 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BFF78_RS11185 ENOG4105CPC Aldo Keto reductase BFF78_RS11220 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BFF78_RS11230 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BFF78_RS11255 ENOG4108JA1 polyketide synthase BFF78_RS11275 ENOG4106A3M Cytochrome p-450 BFF78_RS11295 ENOG4106A3M Cytochrome p-450 BFF78_RS11305 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS11320 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BFF78_RS11330 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS11375 ENOG4105CPC Aldo Keto reductase BFF78_RS11390 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound BFF78_RS11410 ENOG4105CPC Aldo Keto reductase BFF78_RS11425 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BFF78_RS11470 ENOG4105D17 glycoside hydrolase, family 3 domain protein BFF78_RS11490 ENOG4105FDP GntR family transcriptional regulator BFF78_RS11535 ENOG4105CGU Enoyl-CoA hydratase BFF78_RS11545 ENOG4105CUB amino acid BFF78_RS11550 ENOG4105DBV ornithine carbamoyltransferase BFF78_RS11555 ENOG4105CEU Arginine dihydrolase BFF78_RS11570 ENOG4107S1Q Phosphatase BFF78_RS11655 ENOG4105DMF Dehydrogenase BFF78_RS11685 ENOG4105C02 permease BFF78_RS11700 ENOG4106A3M Cytochrome p-450 BFF78_RS11740 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BFF78_RS11745 ENOG4105CPQ Dehydrogenase BFF78_RS11770 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase BFF78_RS11775 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BFF78_RS11790 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BFF78_RS11795 ENOG4105C0X amino acid BFF78_RS11800 ENOG4107VEG TrkA-N domain protein BFF78_RS11840 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BFF78_RS11865 ENOG4106F60 Histidine kinase BFF78_RS11870 ENOG4105F44 Two component transcriptional regulator, winged helix family BFF78_RS11880 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BFF78_RS11915 ENOG4107W53 thymidine kinase BFF78_RS11935 ENOG410849S phosphocarrier protein (HPr) BFF78_RS11940 ENOG4105DRR Transcriptional regulator, GntR family BFF78_RS11945 ENOG4105DR5 peptidase BFF78_RS11960 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BFF78_RS11965 ENOG4107QRP cobalamin biosynthesis protein CobW BFF78_RS11970 ENOG4105BZN citrate synthase BFF78_RS11975 ENOG4105BZN citrate synthase BFF78_RS11985 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BFF78_RS11990 ENOG4107QN1 sodium solute BFF78_RS12000 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS12015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BFF78_RS12030 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS12035 ENOG4105C6F GntR Family Transcriptional Regulator BFF78_RS12040 ENOG4105CJ1 ABC, transporter BFF78_RS12060 ENOG4105C9U ATP-dependent DNA helicase RecQ BFF78_RS12075 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BFF78_RS12095 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BFF78_RS12110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BFF78_RS12115 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BFF78_RS12120 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BFF78_RS12150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BFF78_RS12165 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BFF78_RS12175 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BFF78_RS12195 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BFF78_RS12245 ENOG4108JQC penicillin-binding protein 1A BFF78_RS12295 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BFF78_RS12340 ENOG4105EB3 Histidine kinase BFF78_RS12345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS12350 ENOG4105CDA abc transporter atp-binding protein BFF78_RS12355 ENOG4107UBR Extracellular solute-binding protein family 3 BFF78_RS12360 ENOG4108Q1T ABC transporter BFF78_RS12365 ENOG4105DRP amino acid AbC transporter BFF78_RS12390 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BFF78_RS12425 ENOG4107QRT dEAD DEAH box helicase BFF78_RS12430 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) BFF78_RS12440 ENOG4105WBV Transcriptional regulator BFF78_RS12445 ENOG4105CEV competence damage-inducible protein BFF78_RS12455 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BFF78_RS12470 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BFF78_RS12515 ENOG4105CN5 Metallo-Beta-Lactamase BFF78_RS12520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BFF78_RS12525 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BFF78_RS12540 ENOG4105CHR reductase BFF78_RS12550 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BFF78_RS12555 ENOG4105C1V Peptidase, M16 BFF78_RS12560 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BFF78_RS12565 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BFF78_RS12575 ENOG4108762 serine threonine protein kinase BFF78_RS12615 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BFF78_RS12620 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BFF78_RS12630 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BFF78_RS12640 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) BFF78_RS12655 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase BFF78_RS12660 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BFF78_RS12665 ENOG4108Z7F N-acetyltransferase BFF78_RS12675 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BFF78_RS12680 ENOG4105DZP Membrane-associated zinc metalloprotease BFF78_RS12685 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BFF78_RS12710 ENOG4105C26 Dehydrogenase BFF78_RS12715 ENOG4105G9B Transcriptional regulator BFF78_RS12715 ENOG4105G9B Transcriptional regulator BFF78_RS12750 ENOG4105CJP fad dependent oxidoreductase BFF78_RS12755 ENOG4105D38 putrescine abc transporter BFF78_RS12760 ENOG4105F38 ABC transporter, permease BFF78_RS12765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS12795 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BFF78_RS12800 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BFF78_RS12810 ENOG4105CNF WD-40 repeat protein BFF78_RS12835 ENOG4105ECY inositol monophosphatase BFF78_RS12860 ENOG4105C26 Dehydrogenase BFF78_RS12870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BFF78_RS12875 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BFF78_RS12905 ENOG4108UCS ABC, transporter BFF78_RS12910 ENOG4105ECW sulfate abc transporter BFF78_RS12935 ENOG4105KNE Phosphatidate cytidylyltransferase BFF78_RS12940 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BFF78_RS12945 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BFF78_RS12950 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BFF78_RS12955 ENOG4105CE9 30S ribosomal protein S2 BFF78_RS12960 ENOG41063SB peptidase BFF78_RS12970 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS12985 ENOG41080R2 UPF0102 protein BFF78_RS13010 ENOG4107QYR Signal peptidase i BFF78_RS13025 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BFF78_RS13030 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BFF78_RS13035 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BFF78_RS13040 ENOG41082KU UPF0109 protein BFF78_RS13045 ENOG4105K5M 30s ribosomal protein S16 BFF78_RS13060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BFF78_RS13070 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BFF78_RS13120 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BFF78_RS13130 ENOG4108375 Acylphosphatase (EC 3.6.1.7) BFF78_RS13135 ENOG4105K4I Scp-like extracellular BFF78_RS13140 ENOG4105CS1 NAD(P)H quinone oxidoreductase BFF78_RS13145 ENOG4105KVH Transcriptional regulator BFF78_RS13150 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BFF78_RS13155 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BFF78_RS13160 ENOG41084BZ 50S ribosomal protein L32 BFF78_RS13175 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BFF78_RS13180 ENOG4106H78 methyltransferase BFF78_RS13210 ENOG4105VB9 50S ribosomal protein l28 BFF78_RS13215 ENOG4105DWF phosphomethylpyrimidine kinase BFF78_RS13235 ENOG4105CPF Cell wall formation (By similarity) BFF78_RS13240 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BFF78_RS13260 ENOG4105K70 DNA-binding protein BFF78_RS13270 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BFF78_RS13275 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BFF78_RS13280 ENOG41069M3 Transcriptional regulator BFF78_RS13330 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BFF78_RS13335 ENOG4105ERH Fumarylacetoacetate hydrolase BFF78_RS13350 ENOG4105GWZ Roadblock lc7 family protein BFF78_RS13370 ENOG4105GWZ Roadblock lc7 family protein BFF78_RS13390 ENOG4105D8K carboxyl transferase BFF78_RS13395 ENOG4108YYC ycei family BFF78_RS13415 ENOG4107QK4 glycoside hydrolase, family 3 domain protein BFF78_RS13435 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BFF78_RS13440 ENOG4105CSH Transporter BFF78_RS13455 ENOG4105DWY Agmatine deiminase BFF78_RS13460 ENOG4105CQM Urea amidohydrolase subunit alpha BFF78_RS13475 ENOG4105CM2 brancheD-chain amino acid aminotransferase BFF78_RS13480 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BFF78_RS13490 ENOG4105C26 Dehydrogenase BFF78_RS13500 ENOG4107YHD transcriptional regulator BFF78_RS13500 ENOG4107YHD transcriptional regulator BFF78_RS13510 ENOG4105C57 major facilitator superfamily BFF78_RS13515 ENOG4108JQ1 Dehydrogenase BFF78_RS13520 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BFF78_RS13525 ENOG4108ZP8 Acetolactate synthase small subunit BFF78_RS13535 ENOG4105BZU Histidine kinase BFF78_RS13545 ENOG4105CPC Aldo Keto reductase BFF78_RS13555 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS13575 ENOG4105EYF MMPL domain protein BFF78_RS13580 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BFF78_RS13590 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BFF78_RS13595 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BFF78_RS13615 ENOG4105BZU Histidine kinase BFF78_RS13620 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BFF78_RS13630 ENOG4105EMU Dehydrogenase BFF78_RS13635 ENOG4108URH decarboxylase BFF78_RS13650 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BFF78_RS13675 ENOG4105D29 Helix-turn-helix type 11 domain protein BFF78_RS13695 ENOG4108JQ7 (ABC) transporter BFF78_RS13735 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BFF78_RS13740 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BFF78_RS13745 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BFF78_RS13750 ENOG4105EJQ L-serine dehydratase BFF78_RS13775 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BFF78_RS13785 ENOG4107SNV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BFF78_RS13790 ENOG4105DKW ABC transporter BFF78_RS13815 ENOG4105UPE Enoyl-CoA hydratase BFF78_RS13825 ENOG4107UBC ErfK ybiS ycfS ynhG family protein BFF78_RS13860 ENOG4105BZ1 (ABC) transporter BFF78_RS13875 ENOG4105CJ1 ABC, transporter BFF78_RS13885 ENOG4105BZU Histidine kinase BFF78_RS13890 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS13895 ENOG4105BZ1 (ABC) transporter BFF78_RS13900 ENOG4105BZ1 (ABC) transporter BFF78_RS13935 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BFF78_RS13940 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) BFF78_RS13950 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) BFF78_RS13975 ENOG4105C57 major facilitator superfamily BFF78_RS13985 ENOG4107QJT sodium dicarboxylate symporter BFF78_RS13990 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BFF78_RS13995 ENOG4108MRH transcriptional regulatory protein BFF78_RS14020 ENOG4105CTQ phosphohexokinase BFF78_RS14025 ENOG4105C6K Malic enzyme BFF78_RS14030 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BFF78_RS14070 ENOG4105WX6 Membrane BFF78_RS14125 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS14180 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) BFF78_RS14195 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BFF78_RS14200 ENOG410630P Transcriptional regulator BFF78_RS14225 ENOG4105BZU Histidine kinase BFF78_RS14230 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS14245 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BFF78_RS14250 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BFF78_RS14255 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BFF78_RS14260 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BFF78_RS14265 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BFF78_RS14270 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BFF78_RS14275 ENOG4105ZA1 atp synthase BFF78_RS14285 ENOG4105Z3P ATP synthase BFF78_RS14295 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BFF78_RS14300 ENOG4107ZF2 Phosphatase BFF78_RS14310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BFF78_RS14315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BFF78_RS14320 ENOG4105VFB Binds the 23S rRNA (By similarity) BFF78_RS14335 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BFF78_RS14350 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BFF78_RS14355 ENOG4105C75 arginyL-tRNA synthetase BFF78_RS14355 ENOG4105C75 arginyL-tRNA synthetase BFF78_RS14355 ENOG4105C75 arginyL-tRNA synthetase BFF78_RS14360 ENOG4105ETX regulatoR BFF78_RS14390 ENOG4105FDF Could be involved in DNA repair (By similarity) BFF78_RS14395 ENOG4105DQE DNA ligase BFF78_RS14415 ENOG4108FKE two-component system sensor kinase BFF78_RS14420 ENOG4107QHZ cell cycle protein BFF78_RS14460 ENOG4105ZXU NLP P60 protein BFF78_RS14535 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BFF78_RS14550 ENOG4108PYU two-component system response regulator BFF78_RS14555 ENOG4105EB3 Histidine kinase BFF78_RS14560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BFF78_RS14590 ENOG4105CB2 alcohol dehydrogenase BFF78_RS14595 ENOG4105C6K Malic enzyme BFF78_RS14600 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BFF78_RS14615 ENOG4108VEQ Superoxide dismutase BFF78_RS14620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS14625 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BFF78_RS14630 ENOG4108ZGX Histidine kinase BFF78_RS14635 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS14640 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS14645 ENOG4105BZU Histidine kinase BFF78_RS14675 ENOG4105CG3 alpha amylase, catalytic region BFF78_RS14695 ENOG41060NJ transcriptional regulator BFF78_RS14740 ENOG4105ESN nucleotide-binding protein BFF78_RS14745 ENOG4105K6H D-cysteine desulfhydrase BFF78_RS14760 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BFF78_RS14775 ENOG4105CBD Diacylglycerol kinase BFF78_RS14795 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BFF78_RS14800 ENOG4105FDP GntR family transcriptional regulator BFF78_RS14820 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BFF78_RS14825 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BFF78_RS14830 ENOG41068W2 Cytochrome p-450 BFF78_RS14840 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BFF78_RS14855 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BFF78_RS14860 ENOG4105WMN AntiSigma factor BFF78_RS14865 ENOG4105EMN RNA polymerase sigma factor BFF78_RS14875 ENOG4108RAV Conserved protein BFF78_RS14885 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BFF78_RS14890 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BFF78_RS14895 ENOG4105KPY Small multidrug resistance protein BFF78_RS14905 ENOG4107TK4 histidinol-phosphate phosphatase BFF78_RS14945 ENOG4105DJZ UPF0182 protein BFF78_RS14955 ENOG41063PX domain protein BFF78_RS15020 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BFF78_RS15045 ENOG4105E09 nadh pyrophosphatase BFF78_RS15050 ENOG4107QSE Dipeptidase BFF78_RS15115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BFF78_RS15175 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BFF78_RS15195 ENOG4105D7N magnesium and cobalt transport protein CorA BFF78_RS15230 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BFF78_RS15245 ENOG4105DU6 RNA polymerase BFF78_RS15260 ENOG4105CGU Enoyl-CoA hydratase BFF78_RS15270 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BFF78_RS15280 ENOG4105EEI dihydropteroate synthase BFF78_RS15285 ENOG4108URH decarboxylase BFF78_RS15290 ENOG4107R4C succinyl-diaminopimelate desuccinylase BFF78_RS15310 ENOG4108Z4U Ferredoxin BFF78_RS15325 ENOG4108S01 response regulator BFF78_RS15330 ENOG4105BZU Histidine kinase BFF78_RS15340 ENOG4108M15 ABC transporter BFF78_RS15390 ENOG4105CVR type I restriction-modification system BFF78_RS15395 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BFF78_RS15410 ENOG4108JQ7 (ABC) transporter BFF78_RS15415 ENOG4105C3U ABC transporter BFF78_RS15420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BFF78_RS15425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BFF78_RS15435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BFF78_RS15440 ENOG4108J59 Extracellular solute-binding protein, family 5 BFF78_RS15455 ENOG4108JQ7 (ABC) transporter BFF78_RS15485 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BFF78_RS15490 ENOG4108JQ7 (ABC) transporter BFF78_RS15500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BFF78_RS15505 ENOG4108J59 Extracellular solute-binding protein, family 5 BFF78_RS15510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BFF78_RS15515 ENOG4105CI3 gtp-binding protein typa BFF78_RS15535 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BFF78_RS15585 ENOG4105F27 Major Facilitator BFF78_RS15590 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BFF78_RS15600 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BFF78_RS15615 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) BFF78_RS15630 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BFF78_RS15650 ENOG4108KPJ rna polymerase sigma factor BFF78_RS15675 ENOG4105E2X shikimate dehydrogenase BFF78_RS15695 ENOG4108IQE Amp-dependent synthetase and ligase BFF78_RS15700 ENOG4105C8Y Acetylornithine aminotransferase BFF78_RS15715 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS15725 ENOG4105CSA Coproporphyrinogen iii oxidase BFF78_RS15740 ENOG4105D4P Coproporphyrinogen iii oxidase BFF78_RS15745 ENOG4105CRQ synthase (Component I) BFF78_RS15765 ENOG4105C0W non-ribosomal peptide synthetase BFF78_RS15790 ENOG4105C0W non-ribosomal peptide synthetase BFF78_RS15795 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BFF78_RS15800 ENOG4105EV4 Multidrug resistance protein mdtH BFF78_RS15805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BFF78_RS15810 ENOG4105C3G gtp-binding protein BFF78_RS15825 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BFF78_RS15830 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BFF78_RS15835 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BFF78_RS15840 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) BFF78_RS15865 ENOG4107GFK fumarate BFF78_RS15870 ENOG4105C9Q fumarate hydratase class II BFF78_RS15885 ENOG4105BZ4 penicillin-binding protein BFF78_RS15905 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BFF78_RS15935 ENOG4105D3R alkyl hydroperoxide reductase BFF78_RS15940 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BFF78_RS15950 ENOG4106770 Is able to cleave peptidoglycan (By similarity) BFF78_RS15955 ENOG4108IAB Phoh family BFF78_RS15960 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BFF78_RS15965 ENOG4105F2W methyltransferase BFF78_RS15995 ENOG4107QKZ Ompa motb domain protein BFF78_RS16015 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS16020 ENOG4105RAK Histidine kinase BFF78_RS16070 ENOG4105EQK -acetyltransferase BFF78_RS16080 ENOG4105C6Z Gluconate BFF78_RS16085 ENOG4105KME endoribonuclease L-psp BFF78_RS16090 ENOG4108FUF Transcriptional regulator, IclR family BFF78_RS16120 ENOG4105CHM Aminotransferase BFF78_RS16145 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) BFF78_RS16155 ENOG4105C57 major facilitator superfamily BFF78_RS16190 ENOG4105C7Z Conserved Protein BFF78_RS16220 ENOG4105T1M mycothiol conjugate amidase mca BFF78_RS16230 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BFF78_RS16260 ENOG4105C7B Threonine dehydratase BFF78_RS16265 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BFF78_RS16290 ENOG4105D0M Protease HtpX homolog BFF78_RS16330 ENOG4105DQ4 alcohol dehydrogenase BFF78_RS16370 ENOG4105C84 Histidine ammonia-lyase BFF78_RS16375 ENOG4105KDM Diguanylate cyclase with gaf sensor BFF78_RS16380 ENOG4105E39 Enoyl-CoA hydratase BFF78_RS16390 ENOG4108QER Adenylate cyclase BFF78_RS16400 ENOG4105D8K carboxyl transferase BFF78_RS16410 ENOG4107WR6 Maf-like protein BFF78_RS16420 ENOG4108JIK carboxylase BFF78_RS16445 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BFF78_RS16455 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BFF78_RS16460 ENOG4105C26 Dehydrogenase BFF78_RS16465 ENOG4105C26 Dehydrogenase BFF78_RS16480 ENOG4105NAF rna polymerase sigma factor BFF78_RS16485 ENOG4108KXV response regulator BFF78_RS16490 ENOG41065SU Two-component system sensor kinase BFF78_RS16515 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BFF78_RS16525 ENOG4107RSM transcriptional regulator BFF78_RS16530 ENOG4105D94 Major Facilitator Superfamily BFF78_RS16560 ENOG4105UIB (ABC) transporter BFF78_RS16565 ENOG4108JQ9 ABC transporter BFF78_RS16570 ENOG4105DIH basic membrane BFF78_RS16575 ENOG4107RM1 amidohydrolase BFF78_RS16590 ENOG4105D2T synthase BFF78_RS16595 ENOG4105F0R Cytidylyltransferase BFF78_RS16605 ENOG4105K64 Glycosyl transferase, family 2 BFF78_RS16635 ENOG4108NIW Leucine export protein LeuE BFF78_RS16660 ENOG4108MMM RNA Polymerase BFF78_RS16690 ENOG4105E2D ec 3.2.1.52 BFF78_RS16710 ENOG4108J01 L-aspartate oxidase BFF78_RS16725 ENOG4105U5Y Transcriptional regulator BFF78_RS16745 ENOG4107H3J ribonuclease BFF78_RS16765 ENOG4105C31 Tryptophanyl-tRNA synthetase BFF78_RS16770 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BFF78_RS16775 ENOG4105C8Y Acetylornithine aminotransferase BFF78_RS16780 ENOG4106032 Glutathionylspermidine synthase BFF78_RS16795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS16800 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BFF78_RS16805 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BFF78_RS16820 ENOG4108HQS Glycine betaine BFF78_RS16850 ENOG4105C57 major facilitator superfamily BFF78_RS16855 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BFF78_RS16865 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS16870 ENOG4105BZU Histidine kinase BFF78_RS16880 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BFF78_RS16920 ENOG4105DC1 bifunctional purine biosynthesis protein purh BFF78_RS16960 ENOG4105CMV Succinyl-CoA synthetase subunit beta BFF78_RS16975 ENOG4105DEG Vwa containing coxe family protein BFF78_RS16985 ENOG4105KKX ATPase associated with various cellular activities aaa_5 BFF78_RS17040 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS17090 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BFF78_RS17105 ENOG4105C26 Dehydrogenase BFF78_RS17110 ENOG4108UGD Serine Threonine protein kinase BFF78_RS17115 ENOG4107U32 Beta-lactamase domain protein BFF78_RS17120 ENOG4108DT4 serine threonine protein kinase BFF78_RS17125 ENOG4107TPY serine threonine protein kinase BFF78_RS17130 ENOG4105D9P serine threonine protein kinase BFF78_RS17140 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BFF78_RS17145 ENOG4107QQG Dehydrogenase BFF78_RS17155 ENOG4107QVP Dehydrogenase BFF78_RS17165 ENOG4108MMM RNA Polymerase BFF78_RS17175 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BFF78_RS17180 ENOG4105DND Transcriptional regulator BFF78_RS17190 ENOG4105EMU Dehydrogenase BFF78_RS17200 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BFF78_RS17225 ENOG4105CHP RNA polymerase BFF78_RS17235 ENOG4107TB5 TRANSCRIPTIONal BFF78_RS17260 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BFF78_RS17285 ENOG4108097 ATP-binding protein BFF78_RS17290 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS17295 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BFF78_RS17315 ENOG4105CHR reductase BFF78_RS17320 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BFF78_RS17325 ENOG4105CS9 pantothenic acid kinase BFF78_RS17335 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BFF78_RS17340 ENOG4108UJD 30S ribosomal protein S9 BFF78_RS17355 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BFF78_RS17360 ENOG4108ZT0 50S ribosomal protein l17 BFF78_RS17365 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BFF78_RS17370 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BFF78_RS17375 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BFF78_RS17380 ENOG41067V7 50S ribosomal protein L36 BFF78_RS17385 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BFF78_RS17395 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BFF78_RS17405 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BFF78_RS17410 ENOG410849U 50S ribosomal protein L30 BFF78_RS17415 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BFF78_RS17420 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BFF78_RS17425 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BFF78_RS17430 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BFF78_RS17435 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BFF78_RS17440 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BFF78_RS17445 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BFF78_RS17450 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BFF78_RS17455 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BFF78_RS17460 ENOG41082SA 50s ribosomal protein l29 BFF78_RS17465 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BFF78_RS17470 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BFF78_RS17475 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BFF78_RS17480 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BFF78_RS17485 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BFF78_RS17490 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BFF78_RS17495 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BFF78_RS17500 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BFF78_RS17505 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BFF78_RS17535 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BFF78_RS17540 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BFF78_RS17545 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BFF78_RS17550 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BFF78_RS17555 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BFF78_RS17560 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BFF78_RS17580 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BFF78_RS17590 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BFF78_RS17610 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BFF78_RS17625 ENOG4107R4N Cell wall formation (By similarity) BFF78_RS17645 ENOG410900P UPF0336 protein BFF78_RS17650 ENOG4105WDJ 50S ribosomal protein L33 BFF78_RS17665 ENOG410836F Transposase BFF78_RS17705 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BFF78_RS17710 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BFF78_RS17750 ENOG4105CNU cell division protein FtsK BFF78_RS17775 ENOG4107ZVI PhiRv2 prophage protein BFF78_RS17795 ENOG4108VPT UPF0234 protein BFF78_RS17800 ENOG4105Y3U Transglycosylase-associated protein BFF78_RS17810 ENOG410901E Membrane BFF78_RS17815 ENOG4105D0M Protease HtpX homolog BFF78_RS17820 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS17825 ENOG4105C8S subunit m BFF78_RS17835 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS17840 ENOG4107YX3 NADH dehydrogenase subunit j BFF78_RS17845 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS17850 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BFF78_RS17855 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BFF78_RS17860 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS17865 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BFF78_RS17880 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS17885 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BFF78_RS17890 ENOG4105DQU oxidoreductase, subunit beta BFF78_RS17895 ENOG4105KVH Transcriptional regulator BFF78_RS17900 ENOG4105ECR NmrA family BFF78_RS17930 ENOG4105CJ1 ABC, transporter BFF78_RS17950 ENOG410667J hydrolase BFF78_RS17955 ENOG4105CAY ferredoxin--nadp reductase BFF78_RS17975 ENOG4105FDP GntR family transcriptional regulator BFF78_RS17995 ENOG4108IY8 ABC, transporter BFF78_RS18000 ENOG4108IYU L-aspartate oxidase BFF78_RS18005 ENOG4105C9U ATP-dependent DNA helicase RecQ BFF78_RS18010 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS18020 ENOG4105D65 subunit l BFF78_RS18025 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS18030 ENOG4105DF2 NADH dehydrogenase subunit j BFF78_RS18035 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS18040 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BFF78_RS18045 ENOG4108IEH NADH dehydrogenase subunit g BFF78_RS18050 ENOG4107QIZ NADH dehydrogenase BFF78_RS18060 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS18065 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BFF78_RS18070 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS18085 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BFF78_RS18095 ENOG4105KNA -acetyltransferase BFF78_RS18105 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS18115 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) BFF78_RS18170 ENOG4108EHY type IV secretion system BFF78_RS18210 ENOG4105EC2 ftsk spoIIIe BFF78_RS18275 ENOG4105EV6 Pfam:DUF178 BFF78_RS18280 ENOG4105VEQ Cold shock protein BFF78_RS18285 ENOG4108IMY Transcriptional regulator BFF78_RS18305 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BFF78_RS18340 ENOG4108R86 Transcriptional regulator BFF78_RS18355 ENOG4108UN4 phage SPO1 DNA polymerase-related protein BFF78_RS18360 ENOG4105DVY radical SAM domain protein BFF78_RS18365 ENOG4105EW9 transcriptional regulator AsnC family BFF78_RS18370 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BFF78_RS18375 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BFF78_RS18380 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BFF78_RS18390 ENOG4107V2S Transcriptional regulator BFF78_RS18445 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) BFF78_RS18450 ENOG4107QIV Cytochrome c biogenesis protein BFF78_RS18465 ENOG4108RH7 phosphoglycerate mutase BFF78_RS18470 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BFF78_RS18510 ENOG4108TIT dATP pyrophosphohydrolase BFF78_RS18525 ENOG4105CJ1 ABC, transporter BFF78_RS18545 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BFF78_RS18550 ENOG4108DT4 serine threonine protein kinase BFF78_RS18560 ENOG4105DZ6 Band 7 protein BFF78_RS18575 ENOG4108W5M transcriptional regulator BFF78_RS18590 ENOG4108ME1 Peptidase M55 D-aminopeptidase BFF78_RS18600 ENOG4105CRK lysyL-tRNA synthetase BFF78_RS18610 ENOG4107S4Y M20 DapE family protein YgeY BFF78_RS18615 ENOG41062D9 Histidine kinase BFF78_RS18635 ENOG4105KK4 UPF0060 membrane protein BFF78_RS18645 ENOG4105E0Y RtcB Protein BFF78_RS18665 ENOG4105DK7 lysyl-tRNA synthetase BFF78_RS18670 ENOG4105C75 arginyL-tRNA synthetase BFF78_RS18695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS18700 ENOG4105D52 delta-aminolevulinic acid dehydratase BFF78_RS18715 ENOG4105C79 DNA protecting protein DprA BFF78_RS18740 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BFF78_RS18745 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BFF78_RS18750 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BFF78_RS18755 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BFF78_RS18800 ENOG4105DGU Histone deacetylase BFF78_RS18840 ENOG4105C31 Tryptophanyl-tRNA synthetase BFF78_RS18845 ENOG4105II7 pyrroline-5-carboxylate reductase BFF78_RS18855 ENOG4105CJ1 ABC, transporter BFF78_RS18870 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BFF78_RS18875 ENOG4108762 serine threonine protein kinase BFF78_RS18880 ENOG4105C01 Dihydroxy-acid dehydratase BFF78_RS18890 ENOG4105EY0 Xylose isomerase domain protein TIM barrel BFF78_RS18895 ENOG4107R33 ppx gppa phosphatase BFF78_RS18900 ENOG4108JWX BFF78_RS18915 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BFF78_RS18930 ENOG4105NAF rna polymerase sigma factor BFF78_RS18935 ENOG41075QH Lipoprotein CseA BFF78_RS18940 ENOG4108PYU two-component system response regulator BFF78_RS18945 ENOG4108FKE two-component system sensor kinase BFF78_RS18950 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BFF78_RS18965 ENOG4108IG5 Transcriptional regulator BFF78_RS19020 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BFF78_RS19030 ENOG4108IYU L-aspartate oxidase BFF78_RS19035 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BFF78_RS19060 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS19075 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BFF78_RS19100 ENOG4105CRK lysyL-tRNA synthetase BFF78_RS19130 ENOG4105EUJ GTP cyclohydrolase i BFF78_RS19140 ENOG4108UGV hypoxanthine phosphoribosyltransferase BFF78_RS19145 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BFF78_RS19160 ENOG4105F0N pyrophosphate phospho-hydrolase BFF78_RS19175 ENOG41082VC UPF0145 protein BFF78_RS19180 ENOG4107TXC Transcriptional regulator BFF78_RS19185 ENOG4105VCT ion-transport protein YfeO BFF78_RS19190 ENOG4105CVK Glutamate decarboxylase BFF78_RS19215 ENOG4105C26 Dehydrogenase BFF78_RS19270 ENOG4105C2M dna polymerase I BFF78_RS19340 ENOG4105D8K carboxyl transferase BFF78_RS19355 ENOG4105CZS beta-ketoacyl synthase BFF78_RS19385 ENOG4105CSA Coproporphyrinogen iii oxidase BFF78_RS19400 ENOG4105CHR reductase BFF78_RS19405 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BFF78_RS19425 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BFF78_RS19430 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BFF78_RS19450 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for BFF78_RS19455 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BFF78_RS19460 ENOG4105WN5 stage II sporulation protein BFF78_RS19465 ENOG4108I5C dEAD DEAH box helicase BFF78_RS19525 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BFF78_RS19540 ENOG4105D74 hydrolase BFF78_RS19550 ENOG4105P8F nudix hydrolase BFF78_RS19570 ENOG4108KPJ rna polymerase sigma factor BFF78_RS19580 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BFF78_RS19610 ENOG4105BZ4 penicillin-binding protein BFF78_RS19675 ENOG4105EC2 ftsk spoIIIe BFF78_RS19710 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS19740 ENOG4105M4P Tetr family transcriptional regulator BFF78_RS19750 ENOG410836F Transposase BFF78_RS19800 ENOG4106F60 Histidine kinase BFF78_RS19805 ENOG4107RDB Major Facilitator BFF78_RS19835 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BFF78_RS19840 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BFF78_RS19845 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BFF78_RS19855 ENOG4105C0X amino acid BFF78_RS19885 ENOG4108PJD permease BFF78_RS19920 ENOG4105CFH Aspartokinase BFF78_RS19935 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BFF78_RS19940 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BFF78_RS19955 ENOG4108JPW Aminotransferase BFF78_RS19960 ENOG4108WYP Transcriptional regulator BFF78_RS19980 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BFF78_RS19990 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BFF78_RS20010 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS20015 ENOG4105BZU Histidine kinase BFF78_RS20020 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS20025 ENOG4105BZU Histidine kinase BFF78_RS20045 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BFF78_RS20070 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BFF78_RS20085 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BFF78_RS20115 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BFF78_RS20150 ENOG4105DFW ABC transporter BFF78_RS20255 ENOG4105KNI merR family transcriptional Regulator BFF78_RS20260 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BFF78_RS20265 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BFF78_RS20270 ENOG4105CFG Acts as a chaperone (By similarity) BFF78_RS20280 ENOG4105DF6 Fe-S oxidoreductase BFF78_RS20305 ENOG4108C33 Resolvase BFF78_RS20325 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BFF78_RS20330 ENOG4105DHP deoxycytidine triphosphate deaminase BFF78_RS20365 ENOG4105CVP deoxyribo-dipyrimidine photolyase BFF78_RS20370 ENOG4105CGD Nad-dependent epimerase dehydratase BFF78_RS20390 ENOG4105NAF rna polymerase sigma factor BFF78_RS20395 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS20425 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BFF78_RS20430 ENOG4105CHR reductase BFF78_RS20460 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BFF78_RS20465 ENOG4107TB5 TRANSCRIPTIONal BFF78_RS20470 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BFF78_RS20475 ENOG41082SX arsR family transcriptional regulator BFF78_RS20510 ENOG4105VEQ Cold shock protein BFF78_RS20515 ENOG4105C1J atp-dependent rna helicase BFF78_RS20555 ENOG4105EDW glycosyl transferase, family 39 BFF78_RS20585 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BFF78_RS20600 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS20605 ENOG4105BZU Histidine kinase BFF78_RS20630 ENOG4108ZT1 Transcriptional regulator BFF78_RS20650 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BFF78_RS20675 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BFF78_RS20690 ENOG4105BZ9 Cytochrome C oxidase, subunit I BFF78_RS20715 ENOG4105DU0 nucleoside hydrolase BFF78_RS20720 ENOG4105C22 threonyL-tRNA synthetase BFF78_RS20740 ENOG4105CH2 amidohydrolase BFF78_RS20770 ENOG4105EM2 membrane BFF78_RS20780 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BFF78_RS20790 ENOG4105C9M aspartyl-trna synthetase BFF78_RS20805 ENOG4105EUB pirin domain protein BFF78_RS20815 ENOG4105CSU acyl-Coa dehydrogenase BFF78_RS20820 ENOG4105DFM M18 family aminopeptidase BFF78_RS20835 ENOG41082W1 Cupin 2, conserved barrel domain protein BFF78_RS20840 ENOG4105ECQ AraC Family Transcriptional Regulator BFF78_RS20890 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 BFF78_RS20895 ENOG4105CPP Dehydrogenase, E1 component BFF78_RS20915 ENOG4107QPV Serine Threonine protein kinase BFF78_RS20945 ENOG4107QSN dihydrolipoamide acetyltransferase BFF78_RS20965 ENOG4108IG5 Transcriptional regulator BFF78_RS20970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BFF78_RS20995 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BFF78_RS21000 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit BFF78_RS21005 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit BFF78_RS21010 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit BFF78_RS21015 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BFF78_RS21040 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BFF78_RS21050 ENOG4105TV9 FHA Domain-Containing protein BFF78_RS21055 ENOG4105HZM Fha domain containing protein BFF78_RS21070 ENOG4105CJN penicillin-binding protein BFF78_RS21080 ENOG4108RN7 integral membrane protein BFF78_RS21085 ENOG4108U4N (sortase) family BFF78_RS21095 ENOG4108U4N (sortase) family BFF78_RS21105 ENOG4105ZJT Cell division protein CrgA BFF78_RS21140 ENOG4108UGD Serine Threonine protein kinase BFF78_RS21175 ENOG4108HMN Caspase domain BFF78_RS21180 ENOG4105E2A Dehydrogenase BFF78_RS21200 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BFF78_RS21205 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BFF78_RS21210 ENOG4105K7N UPF0232 protein BFF78_RS21215 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BFF78_RS21220 ENOG4108J5G 6-phosphogluconate dehydrogenase BFF78_RS21225 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BFF78_RS21230 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BFF78_RS21235 ENOG41084CH 50S ribosomal protein l34 BFF78_RS21240 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BFF78_RS21245 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BFF78_RS21255 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BFF78_RS21260 ENOG4107QJE Chromosome Partitioning Protein BFF78_RS21275 ENOG4105K63 Thioredoxin BFF78_RS21280 ENOG4105C3M thioredoxin reductase BFF78_RS21295 ENOG4105D9P serine threonine protein kinase BFF78_RS21310 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BFF78_RS21330 ENOG4108JQC penicillin-binding protein 1A BFF78_RS21355 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) BFF78_RS21360 ENOG4107YH6 single-stranded DNA-binding protein BFF78_RS21365 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BFF78_RS21370 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BFF78_RS21380 ENOG4105CDU Replicative dna helicase BFF78_RS21390 ENOG410849A acetyltransferase, (GNAT) family BFF78_RS21400 ENOG4105F27 Major Facilitator BFF78_RS21435 ENOG4105C28 cystathionine BFF78_RS21440 ENOG4105KJF protein tyrosine phosphatase BFF78_RS21445 ENOG41082T9 Membrane BFF78_RS21450 ENOG4106048 Cupin 2, conserved barrel domain protein BFF78_RS21475 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BFF78_RS21495 ENOG4107P2S Transcriptional regulator BFF78_RS21500 ENOG4105CIH Imidazole acetol-phosphate transaminase BFF78_RS21510 ENOG4105C4M (Ubiquinol oxidase) subunit I BFF78_RS21515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BFF78_RS21520 ENOG4108JJ9 ABC, transporter BFF78_RS21525 ENOG410667J hydrolase BFF78_RS21535 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) BFF78_RS21555 ENOG4105CJ1 ABC, transporter BFF78_RS21580 ENOG410667J hydrolase BFF78_RS21585 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BFF78_RS21595 ENOG4105DBE peroxidase BFF78_RS21635 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS21640 ENOG4107T6F Xaa-Pro aminopeptidase BFF78_RS21660 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BFF78_RS21760 ENOG4108Z4K mutator MutT protein BFF78_RS21800 ENOG4105NAF rna polymerase sigma factor BFF78_RS21805 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS21810 ENOG4108UXN response regulator BFF78_RS21860 ENOG4107RSM transcriptional regulator BFF78_RS21865 ENOG4105CHR reductase BFF78_RS21895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS21900 ENOG4105BZU Histidine kinase BFF78_RS21910 ENOG4105EDW glycosyl transferase, family 39 BFF78_RS21915 ENOG4105C57 major facilitator superfamily BFF78_RS21925 ENOG410905P Pyridoxamine 5-phosphate BFF78_RS21930 ENOG4108YYC ycei family BFF78_RS21935 ENOG4105C0R drug resistance transporter emrb qaca subfamily BFF78_RS21940 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BFF78_RS21955 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS21960 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS21965 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein BFF78_RS21980 ENOG4108Z6B deaminase BFF78_RS21995 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BFF78_RS22050 ENOG4107ZQV short-chain dehydrogenase reductase BFF78_RS22055 ENOG4108T5E Copper resistance protein BFF78_RS22065 ENOG4107RSM transcriptional regulator BFF78_RS22095 ENOG4105CPF Cell wall formation (By similarity) BFF78_RS22100 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BFF78_RS22145 ENOG4108HMN Caspase domain BFF78_RS22190 ENOG4106CY5 excisionase BFF78_RS22195 ENOG4107T65 Integrase BFF78_RS22245 ENOG4105C12 Phosphoribosylglycinamide synthetase BFF78_RS22260 ENOG4105C8V SAICAR synthetase BFF78_RS22305 ENOG410839H phosphoribosylformylglycinamidine synthase BFF78_RS22310 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BFF78_RS22315 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BFF78_RS22335 ENOG4105CXB phosphoribosylaminoimidazole synthetase BFF78_RS22350 ENOG4108TAC BFF78_RS22370 ENOG4105CQ7 ATP-dependent helicase BFF78_RS22410 ENOG4105C1J atp-dependent rna helicase BFF78_RS22440 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS22450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BFF78_RS22470 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BFF78_RS22495 ENOG4105CPC Aldo Keto reductase BFF78_RS22505 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BFF78_RS22510 ENOG4105D5U fad dependent oxidoreductase BFF78_RS22635 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BFF78_RS22650 ENOG4107SN7 NLP P60 protein BFF78_RS22655 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BFF78_RS22660 ENOG4105DNP FAD linked oxidase domain protein BFF78_RS22685 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS22700 ENOG4105CJ3 phosphate transporter BFF78_RS22710 ENOG4105VPX protein, conserved in bacteria BFF78_RS22735 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BFF78_RS22745 ENOG4108UCS ABC, transporter BFF78_RS22750 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS22755 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BFF78_RS22765 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BFF78_RS22790 ENOG4105ETX regulatoR BFF78_RS22805 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS22810 ENOG4107NHD transcriptional regulator BFF78_RS22835 ENOG4105PKJ carbohydrate binding BFF78_RS22840 ENOG4105KHC sulfurtransferase BFF78_RS22885 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands BFF78_RS22905 ENOG41090R7 Ferric uptake BFF78_RS22910 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BFF78_RS22915 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BFF78_RS22925 ENOG4105HHS UPF0256 protein BFF78_RS22940 ENOG4105DRR Transcriptional regulator, GntR family BFF78_RS22945 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BFF78_RS22960 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BFF78_RS22975 ENOG4105YIP Tetr family transcriptional regulator BFF78_RS22985 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BFF78_RS22990 ENOG4105N14 lysine exporter protein LysE YggA BFF78_RS22995 ENOG4107SQD Transcriptional regulator, GntR family BFF78_RS23005 ENOG4108KPJ rna polymerase sigma factor BFF78_RS23035 ENOG4105ZXU NLP P60 protein BFF78_RS23045 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BFF78_RS23050 ENOG4108YZJ Pfam:DUF2596 BFF78_RS23070 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BFF78_RS23100 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BFF78_RS23105 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BFF78_RS23150 ENOG4105CZE histidine utilization repressor BFF78_RS23200 ENOG4105BZU Histidine kinase BFF78_RS23215 ENOG4108VJ1 Transcriptional regulator (CarD family BFF78_RS23220 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BFF78_RS23225 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BFF78_RS23235 ENOG4105C8N cysteinyl-tRNA synthetase BFF78_RS23240 ENOG4105C2N RNA methyltransferase TrmH family group 3 BFF78_RS23300 ENOG4105CD8 aminopeptidase N BFF78_RS23320 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BFF78_RS23340 ENOG4105BZU Histidine kinase BFF78_RS23350 ENOG4106VEM tagatose-6-phosphate kinase BFF78_RS23355 ENOG4105CE4 GlcNAc 6-P deacetylase BFF78_RS23360 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) BFF78_RS23385 ENOG4105C3Q Glycosyl transferase, family 2 BFF78_RS23405 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BFF78_RS23425 ENOG4105EMN RNA polymerase sigma factor BFF78_RS23435 ENOG4105BZ4 penicillin-binding protein BFF78_RS23445 ENOG4105EBR Carboxylesterase BFF78_RS23465 ENOG4105C5Y PTS System BFF78_RS23470 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BFF78_RS23475 ENOG4105QEK Transcriptional regulator BFF78_RS23505 ENOG4106N3A copper homeostasis protein cutc BFF78_RS23515 ENOG4105EEM helicase BFF78_RS23525 ENOG4105CFI type iii restriction protein res subunit BFF78_RS23550 ENOG4105VEQ Cold shock protein BFF78_RS23555 ENOG4105E63 Pfam:DUF178 BFF78_RS23560 ENOG4108UIH futalosine nucleosidase BFF78_RS23570 ENOG4108N0W Major Facilitator superfamily BFF78_RS23580 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BFF78_RS23595 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BFF78_RS23605 ENOG4105C7N Xanthine uracil vitamin C permease BFF78_RS23635 ENOG4105CPC Aldo Keto reductase BFF78_RS23675 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BFF78_RS23680 ENOG4105CQB FAD linked oxidase domain protein BFF78_RS23695 ENOG4107AQZ Membrane BFF78_RS23710 ENOG4107QX3 carboxylase BFF78_RS23725 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS23730 ENOG4105E39 Enoyl-CoA hydratase BFF78_RS23735 ENOG4108IG5 Transcriptional regulator BFF78_RS23750 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BFF78_RS23755 ENOG4108SU4 UPF0309 protein BFF78_RS23770 ENOG4108XEP Alpha Beta Hydrolase Fold protein BFF78_RS23825 ENOG4105WN5 stage II sporulation protein BFF78_RS23840 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS23850 ENOG4105CC9 acyl-Coa dehydrogenase BFF78_RS23855 ENOG4105D2B acyl-CoA dehydrogenase BFF78_RS23875 ENOG4105CC9 acyl-Coa dehydrogenase BFF78_RS23890 ENOG4105D2S major facilitator superfamily BFF78_RS23895 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BFF78_RS23900 ENOG4105MXW flavin reductase domain protein, FMN-binding BFF78_RS23910 ENOG4105CGU Enoyl-CoA hydratase BFF78_RS23920 ENOG4105H3G oxidoreductase BFF78_RS23940 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BFF78_RS23955 ENOG4105D2B acyl-CoA dehydrogenase BFF78_RS23965 ENOG4105N14 lysine exporter protein LysE YggA BFF78_RS23970 ENOG4108ZRZ Transcriptional regulator (AsnC family) BFF78_RS23975 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BFF78_RS23985 ENOG4108762 serine threonine protein kinase BFF78_RS24005 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS24080 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) BFF78_RS24100 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BFF78_RS24140 ENOG41061WM D-Alanyl-D-Alanine BFF78_RS24165 ENOG4108V06 Glutathione peroxidase BFF78_RS24205 ENOG41082YX Transcriptional regulator, arsr family BFF78_RS24210 ENOG41089UC methyltransferase, type 11 BFF78_RS24225 ENOG4105CRE cytochrome C BFF78_RS24230 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS24285 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS24290 ENOG4107HP6 Transcriptional regulator BFF78_RS24320 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BFF78_RS24325 ENOG4108Z7F N-acetyltransferase BFF78_RS24335 ENOG4108Z6Z Transcriptional regulator BFF78_RS24355 ENOG410804X Transcriptional regulator BFF78_RS24360 ENOG4105DE4 1-phosphofructokinase BFF78_RS24365 ENOG4105DM4 PTS System BFF78_RS24405 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) BFF78_RS24410 ENOG4105C0R drug resistance transporter emrb qaca subfamily BFF78_RS24415 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) BFF78_RS24425 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase BFF78_RS24430 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BFF78_RS24440 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BFF78_RS24445 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BFF78_RS24450 ENOG4108Z9I -acetyltransferase BFF78_RS24480 ENOG4105F95 Monooxygenase BFF78_RS24485 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BFF78_RS24490 ENOG4108R85 Short chain dehydrogenase BFF78_RS24510 ENOG4105EYF MMPL domain protein BFF78_RS24515 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BFF78_RS24525 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BFF78_RS24540 ENOG4108ZHJ Organic hydroperoxide resistance protein BFF78_RS24545 ENOG4105K56 Transcriptional regulator BFF78_RS24580 ENOG41069ER domain protein BFF78_RS24590 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BFF78_RS24595 ENOG4105C5H ABC transporter BFF78_RS24635 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BFF78_RS24645 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS24650 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BFF78_RS24655 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BFF78_RS24665 ENOG41067SE Tetr family transcriptional regulator BFF78_RS24675 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BFF78_RS24685 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BFF78_RS24690 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BFF78_RS24695 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BFF78_RS24700 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BFF78_RS24715 ENOG4105BZU Histidine kinase BFF78_RS24765 ENOG4107QN1 sodium solute BFF78_RS24775 ENOG4105C0R drug resistance transporter emrb qaca subfamily BFF78_RS24780 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS24785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS24845 ENOG4105MS9 Resuscitation-promoting factor BFF78_RS24855 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BFF78_RS24875 ENOG4105CEP NADH dehydrogenase BFF78_RS24885 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BFF78_RS24890 ENOG4107RBB ABC transporter, permease BFF78_RS24895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS24930 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS24955 ENOG4105C84 Histidine ammonia-lyase BFF78_RS24995 ENOG4105CGP Urocanate hydratase BFF78_RS25010 ENOG4105CI2 imidazolone-5-propionate hydrolase BFF78_RS25020 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS25025 ENOG41082AN stage II sporulation protein BFF78_RS25055 ENOG4105DUX Transporter BFF78_RS25060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS25065 ENOG41065SU Two-component system sensor kinase BFF78_RS25080 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BFF78_RS25095 ENOG4108Z6Z Transcriptional regulator BFF78_RS25120 ENOG4105C6Y Udp-glucose 6-dehydrogenase BFF78_RS25175 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS25215 ENOG4105N1N Cupin superfamily protein BFF78_RS25235 ENOG4108KGH TRANSCRIPTIONal BFF78_RS25245 ENOG4108KGH TRANSCRIPTIONal BFF78_RS25250 ENOG4108KGH TRANSCRIPTIONal BFF78_RS25260 ENOG4108KGH TRANSCRIPTIONal BFF78_RS25265 ENOG4108KGH TRANSCRIPTIONal BFF78_RS25270 ENOG4108KGH TRANSCRIPTIONal BFF78_RS25285 ENOG4107V9E glucose-1-phosphate thymidylyltransferase BFF78_RS25295 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) BFF78_RS25310 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BFF78_RS25315 ENOG4107RGC Glycosyl transferase, family 2 BFF78_RS25345 ENOG4105EIP mannose-6-phosphate isomerase BFF78_RS25355 ENOG4105DM4 PTS System BFF78_RS25360 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BFF78_RS25405 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BFF78_RS25410 ENOG4108WQ6 secreted protein BFF78_RS25425 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BFF78_RS25430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS25435 ENOG4105BZU Histidine kinase BFF78_RS25440 ENOG4105G3P Lipoprotein lpqB BFF78_RS25450 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea BFF78_RS25455 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS25470 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BFF78_RS25495 ENOG4105C7I Dehydrogenase BFF78_RS25515 ENOG4107SJB teichoic acid biosynthesis BFF78_RS25520 ENOG4105EY8 ABC transporter BFF78_RS25550 ENOG4105K56 Transcriptional regulator BFF78_RS25555 ENOG4108ZHJ Organic hydroperoxide resistance protein BFF78_RS25565 ENOG4107SJB teichoic acid biosynthesis BFF78_RS25570 ENOG4105K64 Glycosyl transferase, family 2 BFF78_RS25575 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component BFF78_RS25595 ENOG4108UGD Serine Threonine protein kinase BFF78_RS25600 ENOG4108QVN serine threonine protein kinase BFF78_RS25605 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BFF78_RS25620 ENOG4105CAK Cell division ATP-binding protein ftsE BFF78_RS25625 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) BFF78_RS25630 ENOG4105CN1 protease BFF78_RS25635 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BFF78_RS25650 ENOG4106NZI LysR family Transcriptional regulator BFF78_RS25660 ENOG4105DQQ Major facilitator superfamily MFS_1 BFF78_RS25680 ENOG4105NPE arsR family transcriptional regulator BFF78_RS25715 ENOG4105EEM helicase BFF78_RS25725 ENOG4108426 dNA-binding protein BFF78_RS25730 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BFF78_RS25735 ENOG4108UJU UPF0301 protein BFF78_RS25745 ENOG4105E2D ec 3.2.1.52 BFF78_RS25805 ENOG4105CUB amino acid BFF78_RS25825 ENOG4105DTQ mandelate racemase muconate lactonizing BFF78_RS25840 ENOG4105E90 ABC transporter BFF78_RS25845 ENOG4108IJ8 ABC transporter BFF78_RS25850 ENOG4105E90 ABC transporter BFF78_RS25860 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BFF78_RS25870 ENOG4105CQB FAD linked oxidase domain protein BFF78_RS25910 ENOG4108RWI nicotinamidase BFF78_RS25920 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BFF78_RS25930 ENOG4105C85 amino acid BFF78_RS25965 ENOG4108RQ5 Beta-lactamase domain-containing protein BFF78_RS25985 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BFF78_RS26020 ENOG4105BZ4 penicillin-binding protein BFF78_RS26045 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BFF78_RS26055 ENOG4106BRA Membrane BFF78_RS26060 ENOG4107QNK )-transporter BFF78_RS26125 ENOG4108U4N (sortase) family BFF78_RS26140 ENOG4105FQP Beta-lactamase BFF78_RS26170 ENOG41090KN UPF0303 protein BFF78_RS26175 ENOG4105D9R oxidoreductase BFF78_RS26190 ENOG41080U6 GntR family transcriptional regulator BFF78_RS26195 ENOG4105MWK D-amino acid dehydrogenase, small subunit BFF78_RS26205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS26210 ENOG4108MP3 ABC transporter, permease BFF78_RS26215 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BFF78_RS26220 ENOG4105CY5 solute-binding protein BFF78_RS26240 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) BFF78_RS26275 ENOG4108M1A Chitin-binding protein BFF78_RS26280 ENOG4105J5T Amp-dependent synthetase and ligase BFF78_RS26340 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BFF78_RS26360 ENOG4105DEN Luciferase family BFF78_RS26365 ENOG4105BZU Histidine kinase BFF78_RS26410 ENOG4105CVJ phosphoglycerate mutase BFF78_RS26435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS26475 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS26485 ENOG4108KPJ rna polymerase sigma factor BFF78_RS26495 ENOG4105C0R drug resistance transporter emrb qaca subfamily BFF78_RS26505 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BFF78_RS26510 ENOG4105ECQ AraC Family Transcriptional Regulator BFF78_RS26530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BFF78_RS26550 ENOG4105E2D ec 3.2.1.52 BFF78_RS26560 ENOG4105DUU IucA IucC family protein BFF78_RS26570 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BFF78_RS26595 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS26600 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BFF78_RS26610 ENOG4107QX3 carboxylase BFF78_RS26625 ENOG4105C29 acyl-CoA thioesterase BFF78_RS26635 ENOG4108XFF BFF78_RS26645 ENOG4105CK7 Sodium proline symporter BFF78_RS26655 ENOG4105C7K acetolactate synthase BFF78_RS26690 ENOG4105EDW glycosyl transferase, family 39 BFF78_RS26715 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BFF78_RS26720 ENOG4105D17 glycoside hydrolase, family 3 domain protein BFF78_RS26740 ENOG410645S MarR family Transcriptional regulator BFF78_RS26750 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS26775 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) BFF78_RS26790 ENOG4108RVA ribokinase BFF78_RS26795 ENOG4105C7H Helicase, RecD TraA family BFF78_RS26825 ENOG4107R13 MMPL domain protein BFF78_RS26830 ENOG4105CPQ Dehydrogenase BFF78_RS26840 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BFF78_RS26855 ENOG4105DH8 myo-inositol catabolism BFF78_RS26860 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BFF78_RS26865 ENOG4105C26 Dehydrogenase BFF78_RS26880 ENOG4105CJ1 ABC, transporter BFF78_RS26915 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BFF78_RS26920 ENOG4105D3Q Sugar transferase BFF78_RS26930 ENOG4105CJR Integral membrane protein (MviN BFF78_RS27040 ENOG4105C5I Dehydrogenase BFF78_RS27085 ENOG4107XGZ Hydrolase BFF78_RS27100 ENOG4106448 streptomycin biosynthesis protein strI BFF78_RS27125 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BFF78_RS27145 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BFF78_RS27150 ENOG4105MC2 DSBA oxidoreductase BFF78_RS27160 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase BFF78_RS27185 ENOG4107XI7 Tetr family transcriptional regulator BFF78_RS27225 ENOG4107V59 shikimate BFF78_RS27235 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BFF78_RS27240 ENOG4105D49 3-dehydroquinate synthase BFF78_RS27290 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS27315 ENOG4105C0R drug resistance transporter emrb qaca subfamily BFF78_RS27410 ENOG4105VHU single-stranded DNA-binding protein BFF78_RS27455 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BFF78_RS27490 ENOG4107UBR Extracellular solute-binding protein family 3 BFF78_RS27505 ENOG4105F8D glycoside hydrolase family 4 BFF78_RS27510 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BFF78_RS27515 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component BFF78_RS27535 ENOG4105D8X mechanosensitive ion channel BFF78_RS27560 ENOG4107SCK Monooxygenase BFF78_RS27580 ENOG4108ZT1 Transcriptional regulator BFF78_RS27675 ENOG4108TCJ secreted hydrolase BFF78_RS27690 ENOG4105MC2 DSBA oxidoreductase BFF78_RS27700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BFF78_RS27705 ENOG4105C85 amino acid BFF78_RS27720 ENOG4105E2Y ABC, transporter BFF78_RS27725 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BFF78_RS27730 ENOG4105GVF (ABC) transporter BFF78_RS27735 ENOG4105E2R ROK family BFF78_RS27750 ENOG4108YZG isomerase BFF78_RS27755 ENOG4105C85 amino acid BFF78_RS27775 ENOG4108TGC Acyltransferase BFF78_RS27795 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BFF78_RS27800 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BFF78_RS27805 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BFF78_RS27810 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BFF78_RS27820 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BFF78_RS27825 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BFF78_RS27835 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BFF78_RS27840 ENOG4105DFF Rod shape-determining protein mreb BFF78_RS27860 ENOG4105CNI cell division protein FtsW BFF78_RS27880 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BFF78_RS27950 ENOG4108YIQ Alpha beta hydrolase BFF78_RS27960 ENOG4107VXZ Hydrolase BFF78_RS28015 ENOG4105C03 ribonuclease BFF78_RS28020 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BFF78_RS28025 ENOG4105K46 50S ribosomal protein l27 BFF78_RS28030 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BFF78_RS28035 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BFF78_RS28040 ENOG4107SJB teichoic acid biosynthesis BFF78_RS28045 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BFF78_RS28055 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BFF78_RS28070 ENOG4105D0M Protease HtpX homolog BFF78_RS28075 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BFF78_RS28090 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BFF78_RS28110 ENOG4107QIZ NADH dehydrogenase BFF78_RS28120 ENOG4105C8T Leucyl-tRNA synthetase BFF78_RS28160 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BFF78_RS28165 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BFF78_RS28195 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BFF78_RS28200 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BFF78_RS28205 ENOG4107QWG 2-Nitropropane dioxygenase BFF78_RS28225 ENOG4107RE3 peptidase, S41 BFF78_RS28230 ENOG4107YU2 histidine triad (hIT) protein BFF78_RS28235 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BFF78_RS28250 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase BFF78_RS28255 ENOG4105EQX glucarate dehydratase BFF78_RS28260 ENOG4107T4Z adenosine kinase BFF78_RS28270 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BFF78_RS28330 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BFF78_RS28360 ENOG4105D4Y metalloprotease BFF78_RS28365 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BFF78_RS28375 ENOG4105EYF MMPL domain protein BFF78_RS28380 ENOG4105BZU Histidine kinase BFF78_RS28385 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS28390 ENOG4108478 ec 3.2.1.18 BFF78_RS28395 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BFF78_RS28400 ENOG4108JQ7 (ABC) transporter BFF78_RS28405 ENOG4105C3U ABC transporter BFF78_RS28415 ENOG4105DEF Extracellular solute-binding protein, family 5 BFF78_RS28450 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BFF78_RS28455 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BFF78_RS28470 ENOG4105FAV ABC, transporter BFF78_RS28475 ENOG4105FDK ABC transporter BFF78_RS28480 ENOG4105DSE periplasmic solute binding protein BFF78_RS28485 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BFF78_RS28490 ENOG410829K Lysine exporter protein (Lyse ygga) BFF78_RS28495 ENOG4105CPC Aldo Keto reductase BFF78_RS28565 ENOG4105E2R ROK family BFF78_RS28570 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BFF78_RS28605 ENOG4107FKK extracellular solute-binding protein family 1 BFF78_RS28615 ENOG4105DRS transport system, permease BFF78_RS28625 ENOG4107QZF nitrite reductase NADPH large subunit BFF78_RS28665 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BFF78_RS28675 ENOG4107GZ4 SanA protein BFF78_RS28685 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BFF78_RS28695 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BFF78_RS28700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS28775 ENOG4107SET aldo keto reductase BFF78_RS28780 ENOG4105BZ8 glutamate synthase BFF78_RS28790 ENOG4105CHR reductase BFF78_RS28835 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BFF78_RS28870 ENOG4107R4N Cell wall formation (By similarity) BFF78_RS28895 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS28910 ENOG4106NZI LysR family Transcriptional regulator BFF78_RS28925 ENOG41069M3 Transcriptional regulator BFF78_RS28930 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BFF78_RS28965 ENOG4105ESN nucleotide-binding protein BFF78_RS28975 ENOG4108PA7 Methyltransferase BFF78_RS28985 ENOG4105CIH Imidazole acetol-phosphate transaminase BFF78_RS28990 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BFF78_RS28995 ENOG4108HWW ABC transporter BFF78_RS29005 ENOG4105DFW ABC transporter BFF78_RS29020 ENOG4105CXK mandelate racemase muconate lactonizing BFF78_RS29035 ENOG4108ZHJ Organic hydroperoxide resistance protein BFF78_RS29040 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BFF78_RS29050 ENOG4105EXN Sulfate transport protein CysZ BFF78_RS29060 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BFF78_RS29070 ENOG4108R86 Transcriptional regulator BFF78_RS29075 ENOG4107QK4 glycoside hydrolase, family 3 domain protein BFF78_RS29085 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BFF78_RS29105 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BFF78_RS29110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BFF78_RS29140 ENOG4105VUF Transcriptional regulator BFF78_RS29145 ENOG4105CPC Aldo Keto reductase BFF78_RS29175 ENOG4105EYW Ion transport protein BFF78_RS29180 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BFF78_RS29225 ENOG4105DAX Pfam:DUF2983 BFF78_RS29295 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 BFF78_RS29310 ENOG4105D29 Helix-turn-helix type 11 domain protein BFF78_RS29330 ENOG4105VTS DnaJ-like, subfamily C BFF78_RS29345 ENOG4105CSH Transporter BFF78_RS29370 ENOG4105F2C Acetyl-CoA acetyltransferase BFF78_RS29375 ENOG4106A3M Cytochrome p-450 BFF78_RS29380 ENOG4105XPP Protein of unknown function (DUF1275) BFF78_RS29395 ENOG4108JJB ABC transporter BFF78_RS29465 ENOG4108SGK Tetr family transcriptional regulator BFF78_RS29470 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BFF78_RS29475 ENOG4107QVI Methyltransferase, type 11 BFF78_RS29495 ENOG4105DYW oxidoreductase BFF78_RS29505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BFF78_RS29555 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS29575 ENOG4108S01 response regulator BFF78_RS29585 ENOG4105BZU Histidine kinase BFF78_RS29600 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BFF78_RS29610 ENOG4105EGD dinuclear metal center protein, YbgI family BFF78_RS29625 ENOG4108UHU Aldolase BFF78_RS29630 ENOG4107XFJ UPF0246 protein BFF78_RS29635 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BFF78_RS29645 ENOG4105E7U AraC family transcriptional regulator BFF78_RS29660 ENOG41061H0 Monooxygenase BFF78_RS29675 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS29680 ENOG4108M8W Monooxygenase BFF78_RS29715 ENOG4105C54 Major Facilitator superfamily BFF78_RS29725 ENOG4105CZQ inner membrane transport protein YdhC BFF78_RS29730 ENOG4107RSM transcriptional regulator BFF78_RS29745 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BFF78_RS29750 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BFF78_RS29760 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BFF78_RS29770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BFF78_RS29775 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BFF78_RS29790 ENOG4108VGI doxx family BFF78_RS29810 ENOG4105C2C drug resistance transporter, Bcr CflA BFF78_RS29815 ENOG4107S1E Beta-lactamase BFF78_RS29835 ENOG4106A0S BFF78_RS29875 ENOG4108478 ec 3.2.1.18 BFF78_RS29890 ENOG4107XZ0 Peptidase M50 BFF78_RS29915 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BFF78_RS29920 ENOG4105C57 major facilitator superfamily BFF78_RS29935 ENOG4105F27 Major Facilitator BFF78_RS29975 ENOG41081JD Transcriptional regulator BFF78_RS29990 ENOG4105C5F glutamine synthetase BFF78_RS30015 ENOG4105FBN Acid phosphatase BFF78_RS30020 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BFF78_RS30030 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS30045 ENOG4105EG2 ABC transporter, permease BFF78_RS30050 ENOG4105CG3 alpha amylase, catalytic region BFF78_RS30070 ENOG41060BG Tetr family transcriptional regulator BFF78_RS30100 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS30115 ENOG4107NHD transcriptional regulator BFF78_RS30120 ENOG4107R5B glutamine synthetase BFF78_RS30130 ENOG4106SPC secreted protein BFF78_RS30135 ENOG4108222 arsenate reductase BFF78_RS30160 ENOG4105D0M Protease HtpX homolog BFF78_RS30185 ENOG4105C5F glutamine synthetase BFF78_RS30195 ENOG4105MXW flavin reductase domain protein, FMN-binding BFF78_RS30210 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BFF78_RS30215 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BFF78_RS30265 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BFF78_RS30285 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BFF78_RS30300 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BFF78_RS30315 ENOG4105CRK lysyL-tRNA synthetase BFF78_RS30320 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BFF78_RS30330 ENOG4108YZT Adenosylcobinamide kinase BFF78_RS30340 ENOG4105C0H protease BFF78_RS30345 ENOG4105DXX methyltransferase BFF78_RS30370 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS30375 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BFF78_RS30395 ENOG4107T4Z adenosine kinase BFF78_RS30405 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) BFF78_RS30410 ENOG4105BZ9 Cytochrome C oxidase, subunit I BFF78_RS30415 ENOG4105MCD Part of cytochrome c oxidase, its function is BFF78_RS30420 ENOG4107UBC ErfK ybiS ycfS ynhG family protein BFF78_RS30430 ENOG4105CCU oxidase (Subunit III) BFF78_RS30440 ENOG4107EUI c reductase, iron-sulfur BFF78_RS30445 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BFF78_RS30450 ENOG4108I0Q anthranilate phosphoribosyltransferase BFF78_RS30455 ENOG4105C9B Cysteine desulfurase BFF78_RS30500 ENOG4105JNK Glycosyl transferase (Group 1 BFF78_RS30525 ENOG4105D0U Arsenite-activated ATPase (ArsA) BFF78_RS30535 ENOG4105DKQ ROK family BFF78_RS30570 ENOG4105ENE Histidine kinase BFF78_RS30580 ENOG4105CTQ phosphohexokinase BFF78_RS30590 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BFF78_RS30600 ENOG4108UQY Iron-storage protein BFF78_RS30610 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BFF78_RS30620 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BFF78_RS30645 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BFF78_RS30665 ENOG4107Z3H Transcriptional regulator, TetR family BFF78_RS30685 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BFF78_RS30705 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BFF78_RS30715 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BFF78_RS30725 ENOG4105CJN penicillin-binding protein BFF78_RS30730 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BFF78_RS30740 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BFF78_RS30745 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BFF78_RS30755 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BFF78_RS30765 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BFF78_RS30770 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BFF78_RS30775 ENOG4105DFA alanine racemase domain protein BFF78_RS30780 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BFF78_RS30795 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BFF78_RS30805 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BFF78_RS30825 ENOG4105CHR reductase BFF78_RS30860 ENOG4105C0B DNA polymerase III (alpha subunit) BFF78_RS30885 ENOG4108Z66 YbaK ebsC protein BFF78_RS30905 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BFF78_RS30910 ENOG4105CIH Imidazole acetol-phosphate transaminase BFF78_RS30915 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BFF78_RS30920 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BFF78_RS30925 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BFF78_RS30930 ENOG4108176 endoribonuclease L-psp BFF78_RS30935 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BFF78_RS30950 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BFF78_RS30960 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BFF78_RS30985 ENOG4105DK0 Indole-3-glycerol phosphate synthase BFF78_RS30990 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BFF78_RS30995 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BFF78_RS31005 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BFF78_RS31015 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BFF78_RS31020 ENOG4108RVA ribokinase BFF78_RS31050 ENOG4105CBC glutamate synthase BFF78_RS31065 ENOG4105MUA Resistance protein BFF78_RS31070 ENOG4108RZE Tetr family transcriptional regulator BFF78_RS31075 ENOG410834F Transcriptional regulator BFF78_RS31095 ENOG41063TF transcriptional regulator (AraC BFF78_RS31100 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BFF78_RS31140 ENOG4108IV0 ABC, transporter BFF78_RS31145 ENOG4105C0Z ABC transporter BFF78_RS31150 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BFF78_RS31155 ENOG4105C32 Amino acid ABC transporter (Permease) BFF78_RS31165 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) BFF78_RS31200 ENOG4105CQ7 ATP-dependent helicase BFF78_RS31205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS31210 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BFF78_RS31220 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BFF78_RS31240 ENOG4108D32 Methyltransferase BFF78_RS31305 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BFF78_RS31315 ENOG4105BZ1 (ABC) transporter BFF78_RS31345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS31350 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BFF78_RS31365 ENOG410836F Transposase BFF78_RS31380 ENOG4105D7N magnesium and cobalt transport protein CorA BFF78_RS31385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS31395 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) BFF78_RS31405 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BFF78_RS31410 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BFF78_RS31415 ENOG4105BZU Histidine kinase BFF78_RS31420 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BFF78_RS31445 ENOG4105CSH Transporter BFF78_RS31450 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BFF78_RS31455 ENOG4105CDA abc transporter atp-binding protein BFF78_RS31460 ENOG4105E5Q amino acid AbC transporter BFF78_RS31465 ENOG4107R0W ABC transporter BFF78_RS31480 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BFF78_RS31490 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS31510 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BFF78_RS31515 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BFF78_RS31520 ENOG4105CHW UPF0052 protein BFF78_RS31525 ENOG4105CIE May be required for sporulation (By similarity) BFF78_RS31535 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BFF78_RS31540 ENOG4105BZA Phosphoglycerate kinase BFF78_RS31545 ENOG4105CP7 Triose-phosphate isomerase BFF78_RS31565 ENOG4107QP8 phosphohexose isomerase BFF78_RS31580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS31585 ENOG4105U3E Transcriptional regulator BFF78_RS31595 ENOG4107T3P ABC, transporter BFF78_RS31600 ENOG4105CG3 alpha amylase, catalytic region BFF78_RS31610 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component BFF78_RS31615 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component BFF78_RS31620 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) BFF78_RS31635 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BFF78_RS31645 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BFF78_RS31660 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BFF78_RS31670 ENOG4105CJ1 ABC, transporter BFF78_RS31675 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BFF78_RS31690 ENOG4105JRK feS assembly protein SufD BFF78_RS31700 ENOG4105C3K feS assembly ATPase SufC BFF78_RS31705 ENOG4105C9B Cysteine desulfurase BFF78_RS31710 ENOG4108UNV SUF system FeS assembly protein, NifU family BFF78_RS31715 ENOG4105VG1 fes assembly suf system protein BFF78_RS31720 ENOG410814C multidrug resistance protein BFF78_RS31725 ENOG4108RFG Tetr family transcriptional regulator BFF78_RS31730 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) BFF78_RS31745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BFF78_RS31800 ENOG4105XEA Tetr family transcriptional regulator BFF78_RS31810 ENOG4105CPQ Dehydrogenase BFF78_RS31830 ENOG4105E98 transcriptional regulator DeoR family BFF78_RS31835 ENOG4105E9Z Nad-dependent epimerase dehydratase BFF78_RS31865 ENOG4105DRR Transcriptional regulator, GntR family BFF78_RS31870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BFF78_RS31885 ENOG4105C7N Xanthine uracil vitamin C permease BFF78_RS31895 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS31900 ENOG4105BZU Histidine kinase BFF78_RS31915 ENOG4107HP6 Transcriptional regulator BFF78_RS31945 ENOG4105C9B Cysteine desulfurase BFF78_RS31950 ENOG4105EV8 ectoine hydroxylase BFF78_RS31955 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BFF78_RS31960 ENOG4108JPW Aminotransferase BFF78_RS31965 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase BFF78_RS31985 ENOG4105C5R Aminotransferase BFF78_RS31990 ENOG4105CT1 (ABC) transporter BFF78_RS31995 ENOG4105EAD ABC transporter BFF78_RS32030 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BFF78_RS32035 ENOG41081F0 Precorrin-8x methylmutase BFF78_RS32040 ENOG4105E4R Precorrin-3B C17-methyltransferase BFF78_RS32050 ENOG4105CIA precorrin-4 C(11)-methyltransferase BFF78_RS32065 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BFF78_RS32070 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BFF78_RS32080 ENOG4105CTK cobaltochelatase, cobn subunit BFF78_RS32085 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BFF78_RS32090 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BFF78_RS32110 ENOG4107W7X Aldolase BFF78_RS32130 ENOG4105C5H ABC transporter BFF78_RS32140 ENOG41060WC Enoyl-CoA hydratase BFF78_RS32150 ENOG4105VBF alkaline shock protein BFF78_RS32180 ENOG4105BZP glycoside hydrolase 15-related BFF78_RS32195 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BFF78_RS32230 ENOG4105E2A Dehydrogenase BFF78_RS32240 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F BFF78_RS32255 ENOG4107QN1 sodium solute BFF78_RS32260 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BFF78_RS32280 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BFF78_RS32340 ENOG4107YCY Transcriptional regulator BFF78_RS32360 ENOG4105EAC phosphoserine phosphatase BFF78_RS32370 ENOG4105IDI abc transporter atp-binding protein BFF78_RS32380 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BFF78_RS32390 ENOG4105ENE Histidine kinase BFF78_RS32395 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS32410 ENOG4105DKW ABC transporter BFF78_RS32430 ENOG4108V1U phospholipid-binding protein BFF78_RS32440 ENOG4108VX5 3-methyladenine DNA glycosylase BFF78_RS32480 ENOG4105DSU hydrolase BFF78_RS32485 ENOG4105DQ5 transport system permease protein BFF78_RS32490 ENOG4105TVJ transport system, permease BFF78_RS32495 ENOG4105E0A ABC, transporter BFF78_RS32515 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BFF78_RS32520 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BFF78_RS32530 ENOG4107QPH glycogen) synthase BFF78_RS32545 ENOG4105BZP glycoside hydrolase 15-related BFF78_RS32550 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BFF78_RS32555 ENOG4108YZ4 nudix hydrolase BFF78_RS32565 ENOG4105DCF alanine dehydrogenase BFF78_RS32580 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BFF78_RS32585 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BFF78_RS32590 ENOG4105FE9 pseudouridine synthase BFF78_RS32595 ENOG41065RQ ADP-ribosylation crystallin J1 BFF78_RS32600 ENOG410756H nucleotidyltransferase BFF78_RS32625 ENOG4105CAT Cytidine monophosphate kinase BFF78_RS32635 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BFF78_RS32650 ENOG4105MS9 Resuscitation-promoting factor BFF78_RS32655 ENOG4105BZ9 Cytochrome C oxidase, subunit I BFF78_RS32665 ENOG410841Q phosphoesterase PA-phosphatase related protein BFF78_RS32675 ENOG4105C57 major facilitator superfamily BFF78_RS32680 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS32685 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BFF78_RS32705 ENOG4106NMR serine protease BFF78_RS32715 ENOG4105C0B DNA polymerase III (alpha subunit) BFF78_RS32725 ENOG4108Z2K Cupin 2, conserved barrel domain protein BFF78_RS32755 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BFF78_RS32770 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS32795 ENOG4107BJW polysaccharide deacetylase BFF78_RS32805 ENOG4106WTF Glycosyl transferase, family 2 BFF78_RS32815 ENOG4108TCJ secreted hydrolase BFF78_RS32825 ENOG41061MD high-affinity nickel-transporter BFF78_RS32840 ENOG4105K6V RNA polymerase BFF78_RS32845 ENOG4105RNG membrane BFF78_RS32885 ENOG4105F1J Homogentisate 1,2-dioxygenase BFF78_RS32900 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BFF78_RS32930 ENOG4107Y9U Membrane BFF78_RS32935 ENOG4108ZHR arsR family transcriptional regulator BFF78_RS32945 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS32965 ENOG4108Z4X TRANSCRIPTIONal BFF78_RS33005 ENOG4105EHZ conserved protein UCP016719 BFF78_RS33015 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS33020 ENOG4108IG5 Transcriptional regulator BFF78_RS33040 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BFF78_RS33045 ENOG4105JP4 Inner membrane protein yidG BFF78_RS33050 ENOG4105VG5 Membrane BFF78_RS33055 ENOG4105PTV Nudix Hydrolase BFF78_RS33080 ENOG4105CPQ Dehydrogenase BFF78_RS33085 ENOG4105CHR reductase BFF78_RS33090 ENOG4105C6Z Gluconate BFF78_RS33095 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BFF78_RS33100 ENOG4105C6F GntR Family Transcriptional Regulator BFF78_RS33105 ENOG4105K5B UPF0225 protein BFF78_RS33115 ENOG4105DCG PHP domain protein BFF78_RS33120 ENOG4105CD8 aminopeptidase N BFF78_RS33135 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BFF78_RS33145 ENOG4105S2J secreted protein BFF78_RS33165 ENOG4105CPC Aldo Keto reductase BFF78_RS33170 ENOG4105DYW oxidoreductase BFF78_RS33180 ENOG4105D7N magnesium and cobalt transport protein CorA BFF78_RS33200 ENOG4105C8N cysteinyl-tRNA synthetase BFF78_RS33210 ENOG4105JXH GntR family transcriptional regulator BFF78_RS33220 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BFF78_RS33225 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BFF78_RS33230 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BFF78_RS33235 ENOG4108K8U Glycerol operon regulatory protein BFF78_RS33240 ENOG4105C3R Methionine synthase BFF78_RS33245 ENOG4107URF beta-phospho-glucomutase BFF78_RS33250 ENOG4105DEF Extracellular solute-binding protein, family 5 BFF78_RS33255 ENOG4105DEF Extracellular solute-binding protein, family 5 BFF78_RS33260 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS33290 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) BFF78_RS33295 ENOG4105E5F proteasome BFF78_RS33300 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) BFF78_RS33305 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) BFF78_RS33310 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) BFF78_RS33320 ENOG4105ETE Transcriptional regulator (LacI family BFF78_RS33330 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) BFF78_RS33365 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BFF78_RS33370 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BFF78_RS33440 ENOG4105HFS 5'-3' exonuclease BFF78_RS33465 ENOG4108Z86 Glutamine amidotransferase BFF78_RS33475 ENOG4105C5F glutamine synthetase BFF78_RS33530 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BFF78_RS33535 ENOG41084BS 50S ribosomal protein L35 BFF78_RS33540 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BFF78_RS33550 ENOG4108RWN rrna methyltransferase BFF78_RS33555 ENOG4105BZU Histidine kinase BFF78_RS33560 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BFF78_RS33565 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BFF78_RS33595 ENOG4105F32 YngK protein BFF78_RS33605 ENOG4105T38 integral membrane protein BFF78_RS33610 ENOG4108K85 Transcriptional regulator BFF78_RS33630 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BFF78_RS33635 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BFF78_RS33640 ENOG4105CAS nag kinase BFF78_RS33645 ENOG4105C8Y Acetylornithine aminotransferase BFF78_RS33650 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BFF78_RS33665 ENOG4108PBA serine threonine protein kinase BFF78_RS33695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS33700 ENOG4105BZU Histidine kinase BFF78_RS33715 ENOG4105CDH Citrulline--aspartate ligase BFF78_RS33720 ENOG4105CH7 arginosuccinase BFF78_RS33730 ENOG4105RJZ Transcriptional regulator BFF78_RS33735 ENOG4105C57 major facilitator superfamily BFF78_RS33740 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS33770 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS33775 ENOG4108UMI ABC transporter, permease BFF78_RS33780 ENOG4105D01 (LipO)protein BFF78_RS33795 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BFF78_RS33800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BFF78_RS33850 ENOG4105CRQ synthase (Component I) BFF78_RS33880 ENOG4105KF0 sporulation and cell division protein, SsgA BFF78_RS33910 ENOG4108JDX DNA polymerase iii, epsilon subunit BFF78_RS33925 ENOG4105C22 threonyL-tRNA synthetase BFF78_RS33950 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase BFF78_RS33955 ENOG4105E2K Glycosyl transferase (Group 1 BFF78_RS33965 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BFF78_RS33970 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BFF78_RS33975 ENOG4105CDY transcriptional regulatory protein BFF78_RS33980 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BFF78_RS33985 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BFF78_RS33990 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BFF78_RS34000 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BFF78_RS34005 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BFF78_RS34010 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BFF78_RS34015 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BFF78_RS34025 ENOG4105C99 atpase involved in dna repair BFF78_RS34030 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) BFF78_RS34040 ENOG4105CUT histidyl-tRNA synthetase BFF78_RS34075 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BFF78_RS34095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BFF78_RS34100 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BFF78_RS34105 ENOG4105HHA aminodeoxychorismate lyase BFF78_RS34110 ENOG4105E2X shikimate dehydrogenase BFF78_RS34115 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BFF78_RS34120 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BFF78_RS34125 ENOG4105D49 3-dehydroquinate synthase BFF78_RS34135 ENOG4105DC7 peptidase M24 BFF78_RS34140 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BFF78_RS34145 ENOG410803B Involved in the transcription termination process (By similarity) BFF78_RS34155 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BFF78_RS34160 ENOG4105CXT aspartate transcarbamylase BFF78_RS34165 ENOG4105CD3 dihydroorotase BFF78_RS34175 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BFF78_RS34180 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BFF78_RS34185 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BFF78_RS34190 ENOG4105SKN orotidine 5''-phosphate decarboxylase BFF78_RS34200 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BFF78_RS34215 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BFF78_RS34230 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BFF78_RS34240 ENOG4105DJV ribulose-phosphate 3-epimerase BFF78_RS34245 ENOG4105DKT Transcriptional regulator BFF78_RS34270 ENOG4105CUB amino acid BFF78_RS34280 ENOG41073TP transcriptional regulator BFF78_RS34290 ENOG4105F38 ABC transporter, permease BFF78_RS34305 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BFF78_RS34355 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) BFF78_RS34360 ENOG4105C2W permease BFF78_RS34380 ENOG4105E2R ROK family BFF78_RS34405 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BFF78_RS34410 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BFF78_RS34415 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase BFF78_RS34420 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BFF78_RS34475 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS34495 ENOG4105EW9 transcriptional regulator AsnC family BFF78_RS34505 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BFF78_RS34515 ENOG4105Q70 BFF78_RS34520 ENOG4105DEU major facilitator superfamily BFF78_RS34530 ENOG4108VW9 Membrane BFF78_RS34535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS34550 ENOG4105JXB ankyrin repeat-containing protein BFF78_RS34565 ENOG4108MJN Glycosyl Transferase BFF78_RS34605 ENOG4105GWZ Roadblock lc7 family protein BFF78_RS34620 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BFF78_RS34625 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BFF78_RS34630 ENOG4105BZU Histidine kinase BFF78_RS34645 ENOG4108UQS dipeptidase BFF78_RS34660 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BFF78_RS34665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BFF78_RS34680 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BFF78_RS34755 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BFF78_RS34765 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BFF78_RS34770 ENOG4105F4R Transcriptional regulator mode BFF78_RS34850 ENOG4107TIF Phenazine biosynthesis protein, PhzF family BFF78_RS34895 ENOG4105CSW GntR family transcriptional regulator BFF78_RS34900 ENOG4108Q5Y Membrane BFF78_RS34940 ENOG4105CHR reductase BFF78_RS34950 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BFF78_RS34980 ENOG4105EP9 oxidoreductase BFF78_RS34985 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BFF78_RS35010 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BFF78_RS35035 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS35050 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BFF78_RS35180 ENOG4108Z0R Transferase BFF78_RS35185 ENOG4108UW5 maltose o-acetyltransferase BFF78_RS35210 ENOG41082SX arsR family transcriptional regulator BFF78_RS35220 ENOG4107QTZ amino acid BFF78_RS35225 ENOG4105K4P CoA-binding domain protein BFF78_RS35240 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BFF78_RS35250 ENOG4105EYH Exonuclease BFF78_RS35290 ENOG4108PSK reductase BFF78_RS35320 ENOG4106HB6 Alpha beta hydrolase BFF78_RS35330 ENOG4108KPJ rna polymerase sigma factor BFF78_RS35335 ENOG4105FDP GntR family transcriptional regulator BFF78_RS35340 ENOG4105DKQ ROK family BFF78_RS35360 ENOG4108VCA G U mismatch-specific DNA glycosylase BFF78_RS35365 ENOG4105C83 adenylosuccinate lyase BFF78_RS35395 ENOG4105FBW Monooxygenase BFF78_RS35405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS35425 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BFF78_RS35430 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BFF78_RS35435 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BFF78_RS35480 ENOG4108YZ9 Urea amidohydrolase subunit gamma BFF78_RS35485 ENOG4105KI2 Urea amidohydrolase subunit beta BFF78_RS35490 ENOG4105CQM Urea amidohydrolase subunit alpha BFF78_RS35500 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BFF78_RS35520 ENOG4105F6E Acyl-transferase BFF78_RS35535 ENOG4105C8Y Acetylornithine aminotransferase BFF78_RS35540 ENOG4105CIK Amidinotransferase BFF78_RS35555 ENOG4105CTQ phosphohexokinase BFF78_RS35560 ENOG4105F1K Glutamine amidotransferase BFF78_RS35570 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BFF78_RS35580 ENOG4105C1G acyl-Coa dehydrogenase BFF78_RS35590 ENOG4106A3M Cytochrome p-450 BFF78_RS35595 ENOG41065KQ synthase BFF78_RS35610 ENOG4105C26 Dehydrogenase BFF78_RS35615 ENOG4105CNG UPF0061 protein BFF78_RS35620 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) BFF78_RS35635 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BFF78_RS35640 ENOG4105D2B acyl-CoA dehydrogenase BFF78_RS35645 ENOG4105D2B acyl-CoA dehydrogenase BFF78_RS35680 ENOG4106W5V Membrane BFF78_RS35685 ENOG4105D74 hydrolase BFF78_RS35755 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BFF78_RS35760 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BFF78_RS35765 ENOG4105EUJ GTP cyclohydrolase i BFF78_RS35775 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BFF78_RS35805 ENOG4105C6T cysteine synthase BFF78_RS35850 ENOG4105C6T cysteine synthase BFF78_RS35905 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BFF78_RS35910 ENOG4105KDC 50s ribosomal protein l28 BFF78_RS35920 ENOG4105NRA 50s ribosomal protein l31 type b BFF78_RS35930 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BFF78_RS35945 ENOG4105CKI cobalamin synthesis protein BFF78_RS35950 ENOG41068HZ 50S ribosomal protein L32 BFF78_RS35980 ENOG4105DIK (ABC) transporter BFF78_RS35985 ENOG4105DSE periplasmic solute binding protein BFF78_RS35995 ENOG4105D0U Arsenite-activated ATPase (ArsA) BFF78_RS36000 ENOG41066UM arsR family transcriptional regulator BFF78_RS36015 ENOG4105CKI cobalamin synthesis protein BFF78_RS36050 ENOG4108TGP Thioesterase superfamily protein BFF78_RS36145 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BFF78_RS36200 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BFF78_RS36225 ENOG4107RB3 L-asparaginase BFF78_RS36230 ENOG4105C5S asparaginyl-tRNA synthetase BFF78_RS36240 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BFF78_RS36250 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BFF78_RS36270 ENOG4105D9P serine threonine protein kinase BFF78_RS36315 ENOG41062IR nudix hydrolase BFF78_RS36350 ENOG4105EMU Dehydrogenase BFF78_RS36360 ENOG4105CRK lysyL-tRNA synthetase BFF78_RS36370 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BFF78_RS36375 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BFF78_RS36415 ENOG4105VF7 tolerance protein BFF78_RS36425 ENOG4105C26 Dehydrogenase BFF78_RS36430 ENOG4107RR1 TRANSCRIPTIONal BFF78_RS36440 ENOG4107SCA Formamidase (EC 3.5.1.49) BFF78_RS36450 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BFF78_RS36455 ENOG4105E2R ROK family BFF78_RS36465 ENOG4105C93 Xylose Isomerase BFF78_RS36500 ENOG4105BZU Histidine kinase BFF78_RS36530 ENOG4105GWZ Roadblock lc7 family protein BFF78_RS36540 ENOG4105C29 acyl-CoA thioesterase BFF78_RS36565 ENOG4105BZ1 (ABC) transporter BFF78_RS36590 ENOG4105BZ1 (ABC) transporter BFF78_RS36595 ENOG4105HHA aminodeoxychorismate lyase BFF78_RS36600 ENOG4105F95 Monooxygenase BFF78_RS36610 ENOG4105E2Y ABC, transporter BFF78_RS36615 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BFF78_RS36620 ENOG4107ZED Uncharacterised protein family UPF0047 BFF78_RS36640 ENOG4105KKX ATPase associated with various cellular activities aaa_5 BFF78_RS36675 ENOG4107VXZ Hydrolase BFF78_RS36690 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BFF78_RS36700 ENOG4105RD7 BadF BadG BcrA BcrD BFF78_RS36705 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BFF78_RS36725 ENOG4105CSU acyl-Coa dehydrogenase BFF78_RS36730 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein BFF78_RS36750 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BFF78_RS36755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BFF78_RS36760 ENOG4105YVS arsR family transcriptional regulator BFF78_RS36765 ENOG4105C2W permease BFF78_RS36825 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BFF78_RS36840 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BFF78_RS36875 ENOG4105PSQ Acyl-transferase BFF78_RS36900 ENOG4105C10 Electron transfer flavoprotein BFF78_RS36910 ENOG4107TPY serine threonine protein kinase BFF78_RS36920 ENOG41060NJ transcriptional regulator BFF78_RS36955 ENOG4105I1F Resistance protein BFF78_RS36965 ENOG4107PP3 Acetylornithine deacetylase BFF78_RS36970 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BFF78_RS36985 ENOG4105BZU Histidine kinase BFF78_RS36990 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS37030 ENOG4105E98 transcriptional regulator DeoR family BFF78_RS37035 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BFF78_RS37045 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) BFF78_RS37050 ENOG4105CF1 Alkylated DNA repair protein BFF78_RS37055 ENOG4105DKQ ROK family BFF78_RS37090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BFF78_RS37095 ENOG4107R34 abc transporter permease protein BFF78_RS37145 ENOG4105MVE transcriptional regulator BFF78_RS37155 ENOG4106F1P AAA ATPase, central domain protein BFF78_RS37180 ENOG4107RRZ synthase BFF78_RS37185 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BFF78_RS37280 ENOG4105CN5 Metallo-Beta-Lactamase BFF78_RS37330 ENOG4105VEQ Cold shock protein BFF78_RS37335 ENOG4105C1J atp-dependent rna helicase BFF78_RS37445 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BFF78_RS37480 ENOG4105D9G High-affinity BFF78_RS37540 ENOG4105EHG Permease protein BFF78_RS37545 ENOG4105E0A ABC, transporter BFF78_RS37565 ENOG4105CAQ asparagine synthetase BFF78_RS37655 ENOG4108HMN Caspase domain BFF78_RS37730 ENOG4105KVH Transcriptional regulator BFF78_RS37910 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) BFF78_RS37915 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d BFF78_RS37930 ENOG4108RWI nicotinamidase BFF78_RS37940 ENOG4105EX0 alpha-galactosidase BFF78_RS37955 ENOG4105KVH Transcriptional regulator BFF78_RS37960 ENOG4107U32 Beta-lactamase domain protein BFF78_RS37980 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BFF78_RS37995 ENOG4105D74 hydrolase BFF78_RS38000 ENOG4105CHU acetyl-coa acetyltransferase BFF78_RS38005 ENOG4107Z3H Transcriptional regulator, TetR family BFF78_RS38010 ENOG4107QN1 sodium solute BFF78_RS38020 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BFF78_RS38065 ENOG4105GWZ Roadblock lc7 family protein BFF78_RS38085 ENOG4107RCI amp-dependent synthetase and ligase BFF78_RS38095 ENOG4107P5I polyketide synthase BFF78_RS38110 ENOG41067SE Tetr family transcriptional regulator BFF78_RS38115 ENOG4105EYF MMPL domain protein BFF78_RS38135 ENOG4105C7W Xanthine dehydrogenase BFF78_RS38155 ENOG4108Q50 Histidine kinase BFF78_RS38210 ENOG41080XP Cbs domain BFF78_RS38215 ENOG4108JQ1 Dehydrogenase BFF78_RS38220 ENOG4106UDK Cellulose-binding, family II BFF78_RS38230 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BFF78_RS38240 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BFF78_RS38305 ENOG4105KJJ Uncharacterized ACR, COG1993 BFF78_RS38315 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BFF78_RS38320 ENOG41073TP transcriptional regulator BFF78_RS38335 ENOG4108IJ0 Aspartate ammonia-lyase BFF78_RS38340 ENOG4105CSV Glutaminase BFF78_RS38345 ENOG41090CE integral membrane protein BFF78_RS38350 ENOG4108U8T Mannosyltransferase BFF78_RS38375 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BFF78_RS38380 ENOG4107U9B transcriptional regulator BFF78_RS38385 ENOG4105I82 acetyl xylan esterase BFF78_RS38430 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BFF78_RS38465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BFF78_RS38490 ENOG4105VDH Dihydroxyacetone kinase BFF78_RS38495 ENOG4108UTZ Dihydroxyacetone kinase BFF78_RS38500 ENOG4105CMT Dihydroxyacetone kinase BFF78_RS38525 ENOG4108YZG isomerase BFF78_RS38540 ENOG4105X7H acyl-CoA dehydrogenase BFF78_RS38550 ENOG4107QRI Phosphoketolase BFF78_RS38560 ENOG4105E2A Dehydrogenase BFF78_RS38585 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BFF78_RS38595 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BFF78_RS38605 ENOG4107QPV Serine Threonine protein kinase BFF78_RS38640 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS38660 ENOG4105WAB arsR family transcriptional regulator BFF78_RS38695 ENOG4105E39 Enoyl-CoA hydratase BFF78_RS38760 ENOG4105KF0 sporulation and cell division protein, SsgA BFF78_RS38770 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BFF78_RS38780 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BFF78_RS38785 ENOG4105CAQ asparagine synthetase BFF78_RS38820 ENOG4105KV4 Transcriptional regulator BFF78_RS38840 ENOG4105DKQ ROK family BFF78_RS38845 ENOG4107QTZ amino acid BFF78_RS38915 ENOG4105CHP RNA polymerase BFF78_RS38920 ENOG4105C26 Dehydrogenase BFF78_RS38945 ENOG4107S5I aldo keto reductase BFF78_RS38955 ENOG4105KVH Transcriptional regulator BFF78_RS38975 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BFF78_RS38980 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BFF78_RS38995 ENOG4108M0I Transcriptional regulator BFF78_RS39000 ENOG4105CPC Aldo Keto reductase BFF78_RS39025 ENOG4105IDI abc transporter atp-binding protein BFF78_RS39035 ENOG4105D9P serine threonine protein kinase BFF78_RS39055 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BFF78_RS39060 ENOG4105WBV Transcriptional regulator BFF78_RS39065 ENOG4105CIR epoxide hydrolase BFF78_RS39080 ENOG4108PA7 Methyltransferase BFF78_RS39090 ENOG4105ESN nucleotide-binding protein BFF78_RS39105 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BFF78_RS39125 ENOG4105C0R drug resistance transporter emrb qaca subfamily BFF78_RS39135 ENOG4107RSM transcriptional regulator BFF78_RS39150 ENOG4107SET aldo keto reductase BFF78_RS39160 ENOG4105KF0 sporulation and cell division protein, SsgA BFF78_RS39170 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BFF78_RS39175 ENOG4107QPV Serine Threonine protein kinase BFF78_RS39180 ENOG4105C7B Threonine dehydratase BFF78_RS39225 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS39270 ENOG4105VEQ Cold shock protein BFF78_RS39280 ENOG4105PDP Short chain dehydrogenase BFF78_RS39340 ENOG4105C5X domain protein BFF78_RS39360 ENOG4105K78 MarR family Transcriptional regulator BFF78_RS39375 ENOG4105BZU Histidine kinase BFF78_RS39445 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) BFF78_RS39450 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BFF78_RS39455 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) BFF78_RS39465 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) BFF78_RS39520 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BFF78_RS39530 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) BFF78_RS39540 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BFF78_RS39545 ENOG4108K8U Glycerol operon regulatory protein BFF78_RS39565 ENOG4107AQZ Membrane BFF78_RS39570 ENOG4105EQ2 LysR family Transcriptional regulator BFF78_RS39610 ENOG4105DQE DNA ligase BFF78_RS39615 ENOG4105DQE DNA ligase BFF78_RS39620 ENOG4107S5I aldo keto reductase BFF78_RS39625 ENOG4105CV8 reductase BFF78_RS39665 ENOG4107RTD sua5 ycio yrdc ywlc family protein BFF78_RS39770 ENOG4105KVH Transcriptional regulator BFF78_RS39780 ENOG4108KXM LysR family Transcriptional regulator BFF78_RS39785 ENOG4107MM9 BNR Asp-box repeat-containing protein BFF78_RS39820 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) BFF78_RS39835 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) BFF78_RS39840 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BFF78_RS39845 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BFF78_RS39855 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BFF78_RS39885 ENOG4105DQR SNARE associated Golgi BFF78_RS39895 ENOG4105CPC Aldo Keto reductase BFF78_RS39900 ENOG4105CSH Transporter BFF78_RS39960 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BFF78_RS39970 ENOG41060NJ transcriptional regulator BFF78_RS40005 ENOG4105KT7 mgtC SapB transporter BFF78_RS40015 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BFF78_RS40020 ENOG4108USZ hydrogenase BFF78_RS40025 ENOG4107RSS Hydrogenase accessory protein HypB BFF78_RS40040 ENOG4105CQS hydrogenase expression formation protein HypD BFF78_RS40045 ENOG4105C45 hydrogenase expression formation protein (HypE) BFF78_RS40050 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BFF78_RS40070 ENOG4105DPX Hydrogenase, large subunit BFF78_RS40110 ENOG4105WH1 Two component transcriptional regulator luxr family BFF78_RS40115 ENOG4105BZU Histidine kinase BFF78_RS40130 ENOG4108PJD permease BFF78_RS40180 ENOG41082SX arsR family transcriptional regulator BFF78_RS40185 ENOG4107TB5 TRANSCRIPTIONal BFF78_RS40200 ENOG4105ECP epimerase BFF78_RS40205 ENOG4105ECP epimerase BFF78_RS40210 ENOG41064MX Tetr family transcriptional regulator BFF78_RS40225 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS40235 ENOG4105CI2 imidazolone-5-propionate hydrolase BFF78_RS40265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS40270 ENOG4105BZU Histidine kinase BFF78_RS40285 ENOG4108VQR secreted hydrolase BFF78_RS40310 ENOG4105K6T rare lipoprotein A BFF78_RS40325 ENOG4105EYF MMPL domain protein BFF78_RS40330 ENOG4107S9F NmrA family BFF78_RS40345 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BFF78_RS40380 ENOG4108IXY short-chain dehydrogenase reductase BFF78_RS40390 ENOG4108KC1 acyl-Coa dehydrogenase BFF78_RS40410 ENOG4105EUB pirin domain protein BFF78_RS40430 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BFF78_RS40445 ENOG4105E7W lamb ycsf family protein BFF78_RS40455 ENOG4107R7A Allophanate hydrolase subunit 2 BFF78_RS40510 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BFF78_RS40515 ENOG4105DNP FAD linked oxidase domain protein BFF78_RS40550 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BFF78_RS40585 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase BFF78_RS40590 ENOG4105DVW rieske (2Fe-2S) BFF78_RS40600 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) BFF78_RS40615 ENOG4108IJ7 Glycine betaine BFF78_RS40620 ENOG4107SQ8 Glycine betaine BFF78_RS40635 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BFF78_RS40640 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BFF78_RS40665 ENOG4105EEI dihydropteroate synthase BFF78_RS40685 ENOG4105EJQ L-serine dehydratase BFF78_RS40690 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BFF78_RS40695 ENOG4105C26 Dehydrogenase BFF78_RS40730 ENOG4105EX0 alpha-galactosidase BFF78_RS40735 ENOG4105E2R ROK family BFF78_RS40740 ENOG4108Q50 Histidine kinase BFF78_RS40750 ENOG4105DYW oxidoreductase BFF78_RS40770 ENOG4105ETX regulatoR BFF78_RS40775 ENOG41062D9 Histidine kinase BFF78_RS40805 ENOG4105C26 Dehydrogenase BFF78_RS40815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BFF78_RS40820 ENOG4105D38 putrescine abc transporter BFF78_RS40825 ENOG4105F38 ABC transporter, permease BFF78_RS40835 ENOG4105DVW rieske (2Fe-2S) BFF78_RS40855 ENOG4105CD5 CoA-binding domain protein BFF78_RS40875 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BFF78_RS40885 ENOG4105CHP RNA polymerase BFF78_RS40890 ENOG4108RQ5 Beta-lactamase domain-containing protein BFF78_RS40895 ENOG4105EXW epimerase dehydratase BFF78_RS40920 ENOG4106W5V Membrane BFF78_RS40925 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BFF78_RS40955 ENOG4105D3Q Sugar transferase BFF78_RS40965 ENOG4105C1B dTDP-glucose 4-6-dehydratase BFF78_RS40970 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BFF78_RS40990 ENOG4107QJZ Glycosyl transferase, family 2 BFF78_RS41040 ENOG4107QQG Dehydrogenase BFF78_RS41060 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BFF78_RS41070 ENOG4107V9E glucose-1-phosphate thymidylyltransferase BFF78_RS41095 ENOG41062D9 Histidine kinase BFF78_RS41105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BFF78_RS41120 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BFF78_RS41140 ENOG4105CHP RNA polymerase BFF78_RS41180 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) BFF78_RS41185 ENOG4105C57 major facilitator superfamily BFF78_RS41250 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BFF78_RS41255 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BFF78_RS41280 ENOG4105ETX regulatoR BFF78_RS41285 ENOG41062D9 Histidine kinase BFF78_RS41380 ENOG4105K4I Scp-like extracellular BFF78_RS41390 ENOG4105CQB FAD linked oxidase domain protein BFF78_RS41420 ENOG4105MKU Transcriptional regulator BFF78_RS41505 ENOG4105CHR reductase BFF78_RS41535 ENOG4108RZE Tetr family transcriptional regulator BFF78_RS41550 ENOG4108HMN Caspase domain BFF78_RS41615 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BFF78_RS41620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BFF78_RS41625 ENOG4107SVN transposase BFF78_RS41690 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) BFF78_RS41725 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BFF78_RS41755 ENOG4107TTQ Alpha beta hydrolase fold BFF78_RS41780 ENOG4108UGD Serine Threonine protein kinase BFF78_RS41840 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BFF78_RS41845 ENOG4105CFG Acts as a chaperone (By similarity) BFF78_RS41850 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BFF78_RS41880 ENOG4105C1J atp-dependent rna helicase BFF78_RS41895 ENOG4105CN5 Metallo-Beta-Lactamase BFF78_RS41900 ENOG4105VEQ Cold shock protein BFF78_RS41945 ENOG4107RWR Sodium hydrogen exchanger BFF78_RS41995 ENOG4105D5G Transposase BFF78_RS42010 ENOG4105MSB protein, conserved in bacteria BFF78_RS42025 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BFF78_RS42040 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein BFF78_RS42050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BFF78_RS42055 ENOG4105CIS alcohol dehydrogenase BFF78_RS42625 ENOG4108UYU AsnC family transcriptional regulator BFF78_RS42795 ENOG4105BZU Histidine kinase BFF78_RS42960 ENOG4105EX0 alpha-galactosidase BFF78_RS43045 ENOG4105CHR reductase BFF78_RS43215 ENOG4105EN6 Membrane BFF78_RS43245 ENOG4105C0H protease BFF78_RS43415 ENOG4105ETX regulatoR BFF78_RS43475 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BFF78_RS43515 ENOG4108XG2 Histidine kinase BFF78_RS43625 ENOG4105W49 UPF0434 protein BFF78_RS43935 ENOG4108UW8 fha domain-containing protein BFF78_RS44180 ENOG4105K4I Scp-like extracellular BFF78_RS44350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BFF78_RS44375 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BFF78_RS44730 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BFF78_RS44735 ENOG4105D6E homoserine dehydrogenase BFF78_RS44820 ENOG4105CHH sulfate transporter BFF78_RS45500 ENOG4105CEY Amp-dependent synthetase and ligase BFF78_RS45605 ENOG4108JA1 polyketide synthase BFF78_RS45935 ENOG4107SVN transposase BFF78_RS46200 ENOG4105DDQ anthranilate synthase BFF78_RS46570 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) BFF78_RS46710 ENOG4108MUZ hydrolase BFF78_RS47005 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein