locus-tag	class	description
BFF78_RS00075	COG1335	isochorismatase
BFF78_RS00080	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BFF78_RS00090	COG0202	RNA polymerase activity
BFF78_RS00110	COG0477	Major facilitator Superfamily
BFF78_RS00195	COG3328	transposase activity
BFF78_RS00215	COG3387	PFAM Glycoside hydrolase 15-related
BFF78_RS00240	COG0667	Aldo Keto reductase
BFF78_RS00260	COG0464	growth
BFF78_RS00270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFF78_RS00270	COG0515	serine threonine protein kinase
BFF78_RS00275	COG1309	transcriptional regulator
BFF78_RS00345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFF78_RS00355	COG3328	transposase activity
BFF78_RS00430	COG1063	alcohol dehydrogenase
BFF78_RS00445	COG3961	Belongs to the TPP enzyme family
BFF78_RS00520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS00610	COG0592	DNA-directed DNA polymerase activity
BFF78_RS00665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFF78_RS00710	COG4213	ABC transporter substrate-binding protein
BFF78_RS00720	COG4214	carbohydrate transport
BFF78_RS00740	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS00790	COG2197	response regulator
BFF78_RS00965	COG3335	DDE superfamily endonuclease
BFF78_RS00975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BFF78_RS01020	COG0596	Alpha beta hydrolase
BFF78_RS01035	COG2226	methyltransferase
BFF78_RS01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFF78_RS01095	COG2318	DinB family
BFF78_RS01100	COG2124	cytochrome p450
BFF78_RS01105	COG3328	transposase activity
BFF78_RS01170	COG3757	hydrolase, family 25
BFF78_RS01175	COG3629	intracellular signal transduction
BFF78_RS01175	COG3903	Transcriptional regulator
BFF78_RS01190	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS01195	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS01230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFF78_RS01285	COG0531	amino acid
BFF78_RS01320	COG3469	chitinase activity
BFF78_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS01330	COG1309	transcriptional regulator
BFF78_RS01340	COG1846	Transcriptional regulator
BFF78_RS01345	COG1902	pentaerythritol trinitrate reductase activity
BFF78_RS01350	COG1309	transcriptional regulator
BFF78_RS01355	COG1063	alcohol dehydrogenase
BFF78_RS01430	COG0667	Aldo Keto reductase
BFF78_RS01550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BFF78_RS01555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BFF78_RS01585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFF78_RS01590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFF78_RS01625	COG2239	Acts as a magnesium transporter
BFF78_RS01680	COG0583	DNA-binding transcription factor activity
BFF78_RS01710	COG3261	NADH dehydrogenase
BFF78_RS01710	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BFF78_RS01715	COG0651	ATP synthesis coupled electron transport
BFF78_RS01725	COG0650	Formate hydrogenlyase subunit 4
BFF78_RS01735	COG3260	NADH ubiquinone oxidoreductase 20
BFF78_RS01750	COG0659	secondary active sulfate transmembrane transporter activity
BFF78_RS01755	COG2824	Alkylphosphonate utilization operon protein PhnA
BFF78_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS01770	COG1024	Enoyl-CoA hydratase
BFF78_RS01790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFF78_RS01800	COG0254	rRNA binding
BFF78_RS01805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BFF78_RS01810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BFF78_RS01815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BFF78_RS01835	COG0183	Belongs to the thiolase family
BFF78_RS01840	COG1309	transcriptional regulator
BFF78_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS01850	COG1024	Enoyl-CoA hydratase
BFF78_RS01855	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS01910	COG2319	Wd-40 repeat
BFF78_RS01910	COG4249	Peptidase C14 caspase catalytic subunit p20
BFF78_RS01970	COG0412	Dienelactone hydrolase
BFF78_RS01990	COG2192	nodulation
BFF78_RS01995	COG0590	tRNA wobble adenosine to inosine editing
BFF78_RS02010	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFF78_RS02015	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFF78_RS02020	COG0730	response to heat
BFF78_RS02030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BFF78_RS02030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS02035	COG2188	Transcriptional regulator
BFF78_RS02055	COG2124	cytochrome p450
BFF78_RS02120	COG0701	Predicted permease
BFF78_RS02135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFF78_RS02140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFF78_RS02145	COG1881	PFAM PEBP family protein
BFF78_RS02165	COG0517	IMP dehydrogenase activity
BFF78_RS02180	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BFF78_RS02230	COG0477	Major facilitator Superfamily
BFF78_RS02235	COG3290	protein histidine kinase activity
BFF78_RS02285	COG0443	Heat shock 70 kDa protein
BFF78_RS02290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFF78_RS02320	COG0018	arginyl-trna synthetase
BFF78_RS02335	COG2378	regulation of single-species biofilm formation
BFF78_RS02345	COG0326	Molecular chaperone. Has ATPase activity
BFF78_RS02385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BFF78_RS02405	COG1131	(ABC) transporter
BFF78_RS02410	COG4585	Histidine kinase
BFF78_RS02415	COG2197	response regulator
BFF78_RS02420	COG3485	protocatechuate 3,4-dioxygenase
BFF78_RS02450	COG4977	sequence-specific DNA binding
BFF78_RS02455	COG0137	argininosuccinate synthase activity
BFF78_RS02525	COG2318	DinB family
BFF78_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS02575	COG0542	response to heat
BFF78_RS02580	COG0583	DNA-binding transcription factor activity
BFF78_RS02605	COG0277	FAD linked oxidase domain protein
BFF78_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS02645	COG0488	(ABC) transporter
BFF78_RS02670	COG2233	PERMEase
BFF78_RS02675	COG0402	S-adenosylhomocysteine deaminase activity
BFF78_RS02685	COG1609	Transcriptional regulator
BFF78_RS02695	COG0793	Belongs to the peptidase S41A family
BFF78_RS02700	COG1733	regulation of RNA biosynthetic process
BFF78_RS02705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BFF78_RS02730	COG3842	ATPase activity
BFF78_RS02735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BFF78_RS02740	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFF78_RS02745	COG1177	transmembrane transport
BFF78_RS02760	COG3979	chitinase
BFF78_RS02790	COG0251	oxidation-reduction process
BFF78_RS02795	COG0583	DNA-binding transcription factor activity
BFF78_RS02800	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS02805	COG0667	Aldo Keto reductase
BFF78_RS02825	COG0531	amino acid
BFF78_RS02835	COG3537	Alpha-1,2-mannosidase
BFF78_RS02860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BFF78_RS02870	COG0300	oxidoreductase activity
BFF78_RS02905	COG2837	iron assimilation
BFF78_RS02945	COG0583	DNA-binding transcription factor activity
BFF78_RS02990	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BFF78_RS03010	COG1982	Orn Lys Arg decarboxylase major
BFF78_RS03050	COG0222	ribosome binding
BFF78_RS03055	COG0248	Ppx GppA phosphatase
BFF78_RS03070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFF78_RS03100	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS03115	COG3469	chitinase activity
BFF78_RS03130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BFF78_RS03140	COG0667	Aldo Keto reductase
BFF78_RS03260	COG2045	Belongs to the ComB family
BFF78_RS03270	COG3290	protein histidine kinase activity
BFF78_RS03285	COG3387	PFAM Glycoside hydrolase 15-related
BFF78_RS03310	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BFF78_RS03325	COG0586	Pfam SNARE associated Golgi protein
BFF78_RS03330	COG0671	phosphoesterase, PA-phosphatase related
BFF78_RS03335	COG0671	phosphoesterase, PA-phosphatase related
BFF78_RS03345	COG2205	protein histidine kinase activity
BFF78_RS03385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BFF78_RS03420	COG2208	phosphoserine phosphatase activity
BFF78_RS03465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BFF78_RS03505	COG0583	DNA-binding transcription factor activity
BFF78_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS03525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS03565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFF78_RS03625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BFF78_RS03625	COG3608	succinylglutamate desuccinylase aspartoacylase
BFF78_RS03645	COG0300	oxidoreductase activity
BFF78_RS03650	COG4948	Mandelate Racemase Muconate Lactonizing
BFF78_RS03665	COG0477	Major facilitator Superfamily
BFF78_RS03670	COG1335	isochorismatase
BFF78_RS03675	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BFF78_RS03690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFF78_RS03700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BFF78_RS03715	COG0515	serine threonine protein kinase
BFF78_RS03725	COG1132	(ABC) transporter
BFF78_RS03730	COG1132	(ABC) transporter
BFF78_RS03735	COG2197	response regulator
BFF78_RS03770	COG2274	protein secretion by the type I secretion system
BFF78_RS03795	COG4221	oxidoreductase activity
BFF78_RS03800	COG3832	glyoxalase III activity
BFF78_RS03820	COG2890	protein-(glutamine-N5) methyltransferase activity
BFF78_RS03865	COG3250	beta-galactosidase activity
BFF78_RS03875	COG1595	DNA-templated transcription, initiation
BFF78_RS03915	COG0667	Aldo Keto reductase
BFF78_RS03950	COG2124	cytochrome p450
BFF78_RS03970	COG0435	Glutathione S-transferase
BFF78_RS03990	COG0531	amino acid
BFF78_RS04010	COG1366	Belongs to the anti-sigma-factor antagonist family
BFF78_RS04015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFF78_RS04020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFF78_RS04025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS04030	COG1006	Multisubunit Na H antiporter MnhC subunit
BFF78_RS04070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BFF78_RS04070	COG1796	DNA polymerase
BFF78_RS04075	COG0546	phosphoglycolate phosphatase activity
BFF78_RS04095	COG2124	cytochrome p450
BFF78_RS04095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BFF78_RS04130	COG2706	6-phosphogluconolactonase activity
BFF78_RS04140	COG1309	transcriptional regulator
BFF78_RS04150	COG1357	PFAM Pentapeptide repeats (8 copies)
BFF78_RS04155	COG1752	Esterase of the alpha-beta hydrolase superfamily
BFF78_RS04170	COG0247	lactate metabolic process
BFF78_RS04175	COG1139	Iron-sulfur cluster binding protein
BFF78_RS04180	COG1556	Lactate utilization protein
BFF78_RS04190	COG0517	IMP dehydrogenase activity
BFF78_RS04190	COG1125	glycine betaine transport
BFF78_RS04200	COG1174	glycine betaine transport
BFF78_RS04205	COG1174	glycine betaine transport
BFF78_RS04215	COG0542	response to heat
BFF78_RS04235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFF78_RS04250	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS04270	COG2207	Transcriptional regulator
BFF78_RS04275	COG3119	arylsulfatase activity
BFF78_RS04315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BFF78_RS04320	COG1793	dna ligase
BFF78_RS04340	COG1846	Transcriptional regulator
BFF78_RS04350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS04420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BFF78_RS04440	COG1116	anion transmembrane transporter activity
BFF78_RS04460	COG2326	polyphosphate kinase activity
BFF78_RS04510	COG3629	intracellular signal transduction
BFF78_RS04520	COG2124	cytochrome p450
BFF78_RS04530	COG0604	alcohol dehydrogenase
BFF78_RS04570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFF78_RS04610	COG0242	peptide deformylase activity
BFF78_RS04630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFF78_RS04640	COG1609	Transcriptional regulator
BFF78_RS04715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BFF78_RS04720	COG0121	glutamine amidotransferase
BFF78_RS04725	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BFF78_RS04730	COG0114	fumarate hydratase activity
BFF78_RS04775	COG3360	Dodecin
BFF78_RS04785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS04810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BFF78_RS04815	COG1053	succinate dehydrogenase
BFF78_RS04825	COG0583	DNA-binding transcription factor activity
BFF78_RS04830	COG0515	serine threonine protein kinase
BFF78_RS04830	COG2815	serine threonine protein kinase
BFF78_RS04870	COG0726	polysaccharide deacetylase
BFF78_RS04880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BFF78_RS04880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFF78_RS04900	COG0531	amino acid
BFF78_RS04925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BFF78_RS04950	COG3618	amidohydrolase
BFF78_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS04970	COG4948	Mandelate Racemase Muconate Lactonizing
BFF78_RS04980	COG1129	ABC transporter
BFF78_RS04985	COG4213	ABC transporter substrate-binding protein
BFF78_RS05010	COG0395	ABC-type sugar transport system, permease component
BFF78_RS05015	COG1175	transmembrane transport
BFF78_RS05035	COG0154	amidase activity
BFF78_RS05060	COG3537	Alpha-1,2-mannosidase
BFF78_RS05070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BFF78_RS05075	COG0297	glycogen (starch) synthase activity
BFF78_RS05095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BFF78_RS05100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BFF78_RS05110	COG4221	oxidoreductase activity
BFF78_RS05130	COG3345	alpha-galactosidase
BFF78_RS05140	COG1175	transmembrane transport
BFF78_RS05145	COG1653	transport
BFF78_RS05160	COG1309	transcriptional regulator
BFF78_RS05165	COG0300	oxidoreductase activity
BFF78_RS05185	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS05255	COG1940	carbohydrate kinase activity
BFF78_RS05255	COG1846	Transcriptional regulator
BFF78_RS05260	COG1129	ABC transporter
BFF78_RS05265	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFF78_RS05270	COG4213	ABC transporter substrate-binding protein
BFF78_RS05275	COG0673	inositol 2-dehydrogenase activity
BFF78_RS05295	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFF78_RS05295	COG1902	pentaerythritol trinitrate reductase activity
BFF78_RS05310	COG1191	sigma factor activity
BFF78_RS05350	COG0071	Belongs to the small heat shock protein (HSP20) family
BFF78_RS05365	COG0542	response to heat
BFF78_RS05375	COG0484	heat shock protein binding
BFF78_RS05380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFF78_RS05385	COG0443	Heat shock 70 kDa protein
BFF78_RS05390	COG3835	regulator
BFF78_RS05420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFF78_RS05430	COG0028	Belongs to the TPP enzyme family
BFF78_RS05450	COG1408	metallophosphoesterase
BFF78_RS05465	COG0583	DNA-binding transcription factor activity
BFF78_RS05470	COG0768	penicillin binding
BFF78_RS05475	COG1309	transcriptional regulator
BFF78_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS05515	COG4977	sequence-specific DNA binding
BFF78_RS05535	COG1802	Transcriptional regulator
BFF78_RS05540	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS05545	COG0583	DNA-binding transcription factor activity
BFF78_RS05560	COG4608	Belongs to the ABC transporter superfamily
BFF78_RS05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFF78_RS05580	COG0747	negative chemotaxis
BFF78_RS05595	COG1609	Transcriptional regulator
BFF78_RS05605	COG1070	Carbohydrate kinase
BFF78_RS05680	COG0714	Associated with various cellular activities
BFF78_RS05760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BFF78_RS05765	COG2080	2 iron, 2 sulfur cluster binding
BFF78_RS05775	COG3469	chitinase activity
BFF78_RS05785	COG1132	(ABC) transporter
BFF78_RS05795	COG1024	Enoyl-CoA hydratase
BFF78_RS05810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BFF78_RS05820	COG0531	amino acid
BFF78_RS05825	COG0668	transmembrane transport
BFF78_RS05835	COG2838	Isocitrate dehydrogenase
BFF78_RS05845	COG2124	cytochrome p450
BFF78_RS05860	COG1404	Belongs to the peptidase S8 family
BFF78_RS05870	COG2197	response regulator
BFF78_RS05880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS05885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS05890	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS05915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS05920	COG3938	Belongs to the proline racemase family
BFF78_RS05930	COG0531	amino acid
BFF78_RS05935	COG2272	Belongs to the type-B carboxylesterase lipase family
BFF78_RS05940	COG4565	transcriptional regulatory protein
BFF78_RS05945	COG3290	protein histidine kinase activity
BFF78_RS05950	COG1116	anion transmembrane transporter activity
BFF78_RS05955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFF78_RS05990	COG1609	Transcriptional regulator
BFF78_RS05995	COG0673	inositol 2-dehydrogenase activity
BFF78_RS06005	COG1609	Transcriptional regulator
BFF78_RS06020	COG0673	inositol 2-dehydrogenase activity
BFF78_RS06050	COG2188	Transcriptional regulator
BFF78_RS06065	COG0395	ABC-type sugar transport system, permease component
BFF78_RS06100	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS06110	COG2267	carboxylic ester hydrolase activity
BFF78_RS06135	COG3851	Histidine kinase
BFF78_RS06145	COG2197	response regulator
BFF78_RS06150	COG0561	phosphatase activity
BFF78_RS06195	COG3959	Transketolase, thiamine diphosphate binding domain
BFF78_RS06200	COG3958	Transketolase
BFF78_RS06215	COG0583	DNA-binding transcription factor activity
BFF78_RS06220	COG0156	8-amino-7-oxononanoate synthase activity
BFF78_RS06225	COG1063	alcohol dehydrogenase
BFF78_RS06275	COG2815	serine threonine protein kinase
BFF78_RS06275	COG0515	serine threonine protein kinase
BFF78_RS06290	COG0431	NADPH-dependent FMN reductase
BFF78_RS06350	COG4221	oxidoreductase activity
BFF78_RS06360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BFF78_RS06370	COG2755	lipolytic protein G-D-S-L family
BFF78_RS06400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BFF78_RS06405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BFF78_RS06420	COG1657	PFAM Prenyltransferase squalene oxidase
BFF78_RS06445	COG1134	teichoic acid transport
BFF78_RS06490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BFF78_RS06505	COG1024	Enoyl-CoA hydratase
BFF78_RS06515	COG4977	sequence-specific DNA binding
BFF78_RS06520	COG2183	response to ionizing radiation
BFF78_RS06525	COG0488	(ABC) transporter
BFF78_RS06540	COG2936	dipeptidyl-peptidase activity
BFF78_RS06550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFF78_RS06560	COG1113	amino acid transport
BFF78_RS06570	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFF78_RS06570	COG1024	Enoyl-CoA hydratase
BFF78_RS06575	COG0183	Belongs to the thiolase family
BFF78_RS06580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFF78_RS06585	COG3268	Saccharopine dehydrogenase
BFF78_RS06595	COG1515	deoxyribonuclease V activity
BFF78_RS06630	COG0488	(ABC) transporter
BFF78_RS06635	COG1834	amidinotransferase
BFF78_RS06690	COG1793	dna ligase
BFF78_RS06715	COG3485	protocatechuate 3,4-dioxygenase
BFF78_RS06720	COG3485	protocatechuate 3,4-dioxygenase
BFF78_RS06725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BFF78_RS06730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS06740	COG1672	PFAM Archaeal ATPase
BFF78_RS06740	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BFF78_RS06775	COG3511	phospholipase C
BFF78_RS06785	COG0366	Alpha amylase catalytic
BFF78_RS06790	COG0395	ABC-type sugar transport system, permease component
BFF78_RS06795	COG1175	transmembrane transport
BFF78_RS06845	COG3469	chitinase activity
BFF78_RS06855	COG1486	melibiose metabolic process
BFF78_RS06865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BFF78_RS06890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFF78_RS06905	COG0166	Belongs to the GPI family
BFF78_RS06910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BFF78_RS06920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFF78_RS06945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFF78_RS06975	COG2084	Dehydrogenase
BFF78_RS06980	COG3467	pyridoxamine 5'-phosphate
BFF78_RS06990	COG0477	Major facilitator Superfamily
BFF78_RS07000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFF78_RS07015	COG0297	glycogen (starch) synthase activity
BFF78_RS07070	COG2723	6-phospho-beta-galactosidase activity
BFF78_RS07075	COG0395	ABC-type sugar transport system, permease component
BFF78_RS07080	COG1175	transmembrane transport
BFF78_RS07085	COG2182	Extracellular solute-binding protein
BFF78_RS07090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFF78_RS07100	COG2124	cytochrome p450
BFF78_RS07160	COG3321	synthase
BFF78_RS07160	COG0604	alcohol dehydrogenase
BFF78_RS07195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS07195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS07200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS07200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS07205	COG0500	methyltransferase
BFF78_RS07215	COG0393	Putative heavy-metal-binding
BFF78_RS07225	COG1609	Transcriptional regulator
BFF78_RS07275	COG0494	nUDIX hydrolase
BFF78_RS07305	COG3835	regulator
BFF78_RS07320	COG4221	oxidoreductase activity
BFF78_RS07330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BFF78_RS07335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BFF78_RS07340	COG0515	serine threonine protein kinase
BFF78_RS07350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BFF78_RS07390	COG0726	polysaccharide deacetylase
BFF78_RS07395	COG0069	glutamate synthase activity
BFF78_RS07405	COG2815	serine threonine protein kinase
BFF78_RS07405	COG0515	serine threonine protein kinase
BFF78_RS07470	COG2197	response regulator
BFF78_RS07480	COG0726	polysaccharide deacetylase
BFF78_RS07500	COG1295	ribonuclease BN
BFF78_RS07535	COG0667	Aldo Keto reductase
BFF78_RS07550	COG2205	protein histidine kinase activity
BFF78_RS07570	COG1136	(ABC) transporter
BFF78_RS07575	COG1136	(ABC) transporter
BFF78_RS07585	COG2205	protein histidine kinase activity
BFF78_RS07610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BFF78_RS07630	COG1278	Cold shock
BFF78_RS07665	COG0772	Belongs to the SEDS family
BFF78_RS07670	COG0640	Transcriptional regulator
BFF78_RS07720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFF78_RS07730	COG1968	undecaprenyl-diphosphatase activity
BFF78_RS07735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BFF78_RS07740	COG0640	Transcriptional regulator
BFF78_RS07785	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BFF78_RS07835	COG2172	sigma factor antagonist activity
BFF78_RS07840	COG1366	Belongs to the anti-sigma-factor antagonist family
BFF78_RS07845	COG1366	Belongs to the anti-sigma-factor antagonist family
BFF78_RS07870	COG0842	Transport permease protein
BFF78_RS07870	COG1716	ATPase activity
BFF78_RS07870	COG1131	(ABC) transporter
BFF78_RS07940	COG3328	transposase activity
BFF78_RS08090	COG2124	cytochrome p450
BFF78_RS08155	COG3103	Sh3 type 3 domain protein
BFF78_RS08155	COG0791	NLP P60 protein
BFF78_RS08155	COG1388	LysM domain
BFF78_RS08215	COG0714	Associated with various cellular activities
BFF78_RS08360	COG1830	Aldolase
BFF78_RS08405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFF78_RS08450	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BFF78_RS08460	COG1111	helicase
BFF78_RS08460	COG1205	dead DEAH box helicase
BFF78_RS08465	COG0515	serine threonine protein kinase
BFF78_RS08465	COG2815	serine threonine protein kinase
BFF78_RS08475	COG0515	serine threonine protein kinase
BFF78_RS08475	COG2815	serine threonine protein kinase
BFF78_RS08600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFF78_RS08605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BFF78_RS08610	COG0583	DNA-binding transcription factor activity
BFF78_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS08620	COG1335	isochorismatase
BFF78_RS08625	COG1846	Transcriptional regulator
BFF78_RS08655	COG3250	beta-galactosidase activity
BFF78_RS08670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BFF78_RS08685	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BFF78_RS08690	COG0656	L-ascorbic acid biosynthetic process
BFF78_RS08710	COG2226	methyltransferase
BFF78_RS08720	COG3511	phospholipase C
BFF78_RS08725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BFF78_RS08725	COG4106	trans-aconitate 2-methyltransferase activity
BFF78_RS08730	COG2154	pterin-4-alpha-carbinolamine dehydratase
BFF78_RS08755	COG0443	Heat shock 70 kDa protein
BFF78_RS08810	COG0028	Belongs to the TPP enzyme family
BFF78_RS08825	COG0693	protein deglycase activity
BFF78_RS08840	COG0488	(ABC) transporter
BFF78_RS08850	COG0406	alpha-ribazole phosphatase activity
BFF78_RS08855	COG1597	lipid kinase activity
BFF78_RS08860	COG2226	methyltransferase
BFF78_RS08965	COG1619	proteins homologs of microcin C7 resistance protein MccF
BFF78_RS08975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFF78_RS08980	COG2362	D-Aminopeptidase
BFF78_RS08985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFF78_RS08990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFF78_RS08990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFF78_RS09040	COG0456	acetyltransferase
BFF78_RS09050	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFF78_RS09065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS09065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS09070	COG2301	Belongs to the HpcH HpaI aldolase family
BFF78_RS09080	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS09085	COG0688	phosphatidylethanolamine metabolic process
BFF78_RS09100	COG1929	Belongs to the glycerate kinase type-1 family
BFF78_RS09120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BFF78_RS09155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BFF78_RS09185	COG0483	inositol monophosphate 1-phosphatase activity
BFF78_RS09210	COG1953	Uracil, thiamine, allantoin
BFF78_RS09220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BFF78_RS09235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFF78_RS09260	COG0542	response to heat
BFF78_RS09265	COG0405	Gamma-glutamyltransferase
BFF78_RS09300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS09335	COG1302	Protein conserved in bacteria
BFF78_RS09370	COG0330	HflC and HflK could
BFF78_RS09375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFF78_RS09450	COG2124	cytochrome p450
BFF78_RS09450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BFF78_RS09455	COG1063	alcohol dehydrogenase
BFF78_RS09485	COG0346	lactoylglutathione lyase activity
BFF78_RS09490	COG0179	Fumarylacetoacetate (FAA) hydrolase
BFF78_RS09500	COG2208	phosphoserine phosphatase activity
BFF78_RS09500	COG2770	Histidine kinase
BFF78_RS09510	COG1366	Belongs to the anti-sigma-factor antagonist family
BFF78_RS09525	COG2860	membrane
BFF78_RS09530	COG1473	amidohydrolase
BFF78_RS09655	COG3629	intracellular signal transduction
BFF78_RS09655	COG3903	Transcriptional regulator
BFF78_RS09665	COG3903	Transcriptional regulator
BFF78_RS09665	COG3629	intracellular signal transduction
BFF78_RS09675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFF78_RS09680	COG0142	geranyltranstransferase activity
BFF78_RS09690	COG2409	Drug exporters of the RND superfamily
BFF78_RS09695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BFF78_RS09715	COG3483	tryptophan 2,3-dioxygenase activity
BFF78_RS09730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS09745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS09750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS09770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFF78_RS09775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFF78_RS09780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFF78_RS09820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFF78_RS09830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFF78_RS09845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BFF78_RS09860	COG0300	oxidoreductase activity
BFF78_RS09860	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS09860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS09860	COG3321	synthase
BFF78_RS09890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BFF78_RS09900	COG1940	carbohydrate kinase activity
BFF78_RS09920	COG2188	Transcriptional regulator
BFF78_RS09925	COG0673	inositol 2-dehydrogenase activity
BFF78_RS09935	COG2197	response regulator
BFF78_RS09955	COG0142	geranyltranstransferase activity
BFF78_RS09995	COG4266	Belongs to the allantoicase family
BFF78_RS10000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BFF78_RS10005	COG1414	Transcriptional regulator
BFF78_RS10015	COG0746	molybdenum cofactor guanylyltransferase activity
BFF78_RS10030	COG3275	phosphorelay sensor kinase activity
BFF78_RS10035	COG2340	Cysteine-rich secretory protein family
BFF78_RS10045	COG4264	IucA IucC family
BFF78_RS10060	COG1733	regulation of RNA biosynthetic process
BFF78_RS10065	COG0436	Aminotransferase
BFF78_RS10080	COG0406	alpha-ribazole phosphatase activity
BFF78_RS10095	COG2233	PERMEase
BFF78_RS10115	COG2351	hydroxyisourate hydrolase activity
BFF78_RS10150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFF78_RS10200	COG3622	Belongs to the hyi family
BFF78_RS10205	COG2084	Dehydrogenase
BFF78_RS10210	COG0753	catalase activity
BFF78_RS10220	COG3960	tartronate-semialdehyde synthase activity
BFF78_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS10240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFF78_RS10245	COG2197	response regulator
BFF78_RS10265	COG0598	Magnesium transport protein CorA
BFF78_RS10275	COG0726	polysaccharide deacetylase
BFF78_RS10285	COG1280	lysine exporter protein (LysE YggA)
BFF78_RS10295	COG2252	PERMEase
BFF78_RS10300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFF78_RS10330	COG1802	Transcriptional regulator
BFF78_RS10345	COG0028	Belongs to the TPP enzyme family
BFF78_RS10370	COG2267	carboxylic ester hydrolase activity
BFF78_RS10380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFF78_RS10395	COG1162	GTPase activity
BFF78_RS10400	COG1278	Cold shock
BFF78_RS10405	COG0513	Belongs to the DEAD box helicase family
BFF78_RS10430	COG1940	carbohydrate kinase activity
BFF78_RS10450	COG0596	Alpha beta hydrolase
BFF78_RS10505	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS10535	COG0175	sulfate reduction
BFF78_RS10540	COG0529	Catalyzes the synthesis of activated sulfate
BFF78_RS10560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BFF78_RS10565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFF78_RS10580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BFF78_RS10595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BFF78_RS10650	COG0583	DNA-binding transcription factor activity
BFF78_RS10655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFF78_RS10680	COG3173	Aminoglycoside phosphotransferase
BFF78_RS10705	COG0504	CTP synthase activity
BFF78_RS10720	COG0596	Alpha beta hydrolase
BFF78_RS10770	COG0640	Transcriptional regulator
BFF78_RS10795	COG0477	Major facilitator Superfamily
BFF78_RS10800	COG1732	Glycine betaine
BFF78_RS10805	COG1174	glycine betaine transport
BFF78_RS10810	COG1174	glycine betaine transport
BFF78_RS10840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BFF78_RS10845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFF78_RS10880	COG0330	HflC and HflK could
BFF78_RS10885	COG1881	PFAM PEBP family protein
BFF78_RS10890	COG2326	polyphosphate kinase activity
BFF78_RS10895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFF78_RS10895	COG0723	plastoquinol--plastocyanin reductase activity
BFF78_RS10910	COG4152	abc transporter atp-binding protein
BFF78_RS10930	COG3220	belongs to the UPF0276 family
BFF78_RS10965	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFF78_RS10980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BFF78_RS11000	COG0183	Belongs to the thiolase family
BFF78_RS11005	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFF78_RS11005	COG1024	Enoyl-CoA hydratase
BFF78_RS11040	COG0531	amino acid
BFF78_RS11045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BFF78_RS11050	COG4214	carbohydrate transport
BFF78_RS11060	COG4213	ABC transporter substrate-binding protein
BFF78_RS11065	COG1940	carbohydrate kinase activity
BFF78_RS11070	COG0395	ABC-type sugar transport system, permease component
BFF78_RS11075	COG1175	transmembrane transport
BFF78_RS11080	COG1653	transport
BFF78_RS11090	COG3537	Alpha-1,2-mannosidase
BFF78_RS11095	COG3290	protein histidine kinase activity
BFF78_RS11105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BFF78_RS11110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BFF78_RS11125	COG3977	Valine--pyruvate aminotransferase
BFF78_RS11185	COG0667	Aldo Keto reductase
BFF78_RS11230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BFF78_RS11255	COG3321	synthase
BFF78_RS11255	COG0604	alcohol dehydrogenase
BFF78_RS11275	COG2124	cytochrome p450
BFF78_RS11295	COG2124	cytochrome p450
BFF78_RS11305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS11320	COG0644	oxidoreductase
BFF78_RS11330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS11375	COG0667	Aldo Keto reductase
BFF78_RS11390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BFF78_RS11410	COG0667	Aldo Keto reductase
BFF78_RS11470	COG1472	Belongs to the glycosyl hydrolase 3 family
BFF78_RS11475	COG0395	ABC-type sugar transport system, permease component
BFF78_RS11480	COG1175	transmembrane transport
BFF78_RS11485	COG2182	Extracellular solute-binding protein
BFF78_RS11490	COG2188	Transcriptional regulator
BFF78_RS11535	COG1024	Enoyl-CoA hydratase
BFF78_RS11545	COG0531	amino acid
BFF78_RS11550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BFF78_RS11555	COG2235	arginine
BFF78_RS11570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BFF78_RS11610	COG1799	cell septum assembly
BFF78_RS11680	COG1597	lipid kinase activity
BFF78_RS11685	COG0628	permease
BFF78_RS11700	COG2124	cytochrome p450
BFF78_RS11740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BFF78_RS11740	COG2124	cytochrome p450
BFF78_RS11745	COG1063	alcohol dehydrogenase
BFF78_RS11770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS11775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFF78_RS11790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BFF78_RS11795	COG0531	amino acid
BFF78_RS11800	COG0569	domain protein
BFF78_RS11840	COG0756	dUTP diphosphatase activity
BFF78_RS11865	COG2205	protein histidine kinase activity
BFF78_RS11870	COG0745	RESPONSE REGULATOR receiver
BFF78_RS11915	COG1435	thymidine kinase activity
BFF78_RS11935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFF78_RS11940	COG1802	Transcriptional regulator
BFF78_RS11945	COG0739	heme binding
BFF78_RS11955	COG0612	Peptidase, M16
BFF78_RS11960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFF78_RS11970	COG0372	Belongs to the citrate synthase family
BFF78_RS11985	COG3290	protein histidine kinase activity
BFF78_RS11990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFF78_RS12000	COG2197	response regulator
BFF78_RS12015	COG0187	DNA topoisomerase II activity
BFF78_RS12030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFF78_RS12035	COG2186	Transcriptional regulator
BFF78_RS12040	COG1131	(ABC) transporter
BFF78_RS12075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BFF78_RS12095	COG0588	phosphoglycerate mutase activity
BFF78_RS12110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFF78_RS12115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BFF78_RS12120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BFF78_RS12150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BFF78_RS12165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BFF78_RS12175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BFF78_RS12195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFF78_RS12245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFF78_RS12295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFF78_RS12340	COG2205	protein histidine kinase activity
BFF78_RS12345	COG0745	RESPONSE REGULATOR receiver
BFF78_RS12350	COG1126	abc transporter atp-binding protein
BFF78_RS12355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFF78_RS12360	COG0765	amino acid transport
BFF78_RS12365	COG0765	amino acid transport
BFF78_RS12390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BFF78_RS12425	COG1201	RNA secondary structure unwinding
BFF78_RS12430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BFF78_RS12440	COG1396	sequence-specific DNA binding
BFF78_RS12445	COG1058	Belongs to the CinA family
BFF78_RS12445	COG1546	Belongs to the CinA family
BFF78_RS12455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFF78_RS12475	COG2205	protein histidine kinase activity
BFF78_RS12475	COG0784	Response regulator, receiver
BFF78_RS12480	COG2770	Histidine kinase
BFF78_RS12480	COG2208	phosphoserine phosphatase activity
BFF78_RS12515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BFF78_RS12520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS12525	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BFF78_RS12540	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS12550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BFF78_RS12555	COG0612	Peptidase, M16
BFF78_RS12560	COG1185	polyribonucleotide nucleotidyltransferase activity
BFF78_RS12565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BFF78_RS12575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFF78_RS12575	COG0515	serine threonine protein kinase
BFF78_RS12615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BFF78_RS12620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BFF78_RS12630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BFF78_RS12640	COG0779	Required for maturation of 30S ribosomal subunits
BFF78_RS12660	COG0442	prolyl-tRNA aminoacylation
BFF78_RS12665	COG1247	-acetyltransferase
BFF78_RS12675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BFF78_RS12680	COG0750	zinc metalloprotease
BFF78_RS12685	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BFF78_RS12710	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS12715	COG2508	Transcriptional regulator
BFF78_RS12715	COG2508	Transcriptional regulator
BFF78_RS12750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFF78_RS12755	COG1177	transmembrane transport
BFF78_RS12760	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFF78_RS12765	COG3842	ATPase activity
BFF78_RS12795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BFF78_RS12800	COG0584	glycerophosphoryl diester phosphodiesterase
BFF78_RS12810	COG2319	Wd-40 repeat
BFF78_RS12810	COG5635	Nacht domain
BFF78_RS12835	COG0483	inositol monophosphate 1-phosphatase activity
BFF78_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS12870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFF78_RS12905	COG3842	ATPase activity
BFF78_RS12910	COG4208	sulfate ABC transporter
BFF78_RS12935	COG0575	Belongs to the CDS family
BFF78_RS12940	COG0233	cytoplasmic translational termination
BFF78_RS12945	COG0528	UMP kinase activity
BFF78_RS12950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BFF78_RS12955	COG0052	Belongs to the universal ribosomal protein uS2 family
BFF78_RS12960	COG4942	peptidase
BFF78_RS12970	COG1191	sigma factor activity
BFF78_RS12985	COG0792	nuclease activity
BFF78_RS13010	COG0681	Belongs to the peptidase S26 family
BFF78_RS13025	COG0335	large ribosomal subunit rRNA binding
BFF78_RS13030	COG0336	Belongs to the RNA methyltransferase TrmD family
BFF78_RS13035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BFF78_RS13040	COG1837	Belongs to the UPF0109 family
BFF78_RS13045	COG0228	four-way junction DNA binding
BFF78_RS13060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFF78_RS13070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BFF78_RS13115	COG0477	Major facilitator Superfamily
BFF78_RS13120	COG1196	nuclear chromosome segregation
BFF78_RS13130	COG1254	Belongs to the acylphosphatase family
BFF78_RS13135	COG2340	Cysteine-rich secretory protein family
BFF78_RS13140	COG0655	NAD(P)H dehydrogenase (quinone) activity
BFF78_RS13145	COG1733	regulation of RNA biosynthetic process
BFF78_RS13150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BFF78_RS13155	COG0571	ribonuclease III activity
BFF78_RS13160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BFF78_RS13175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BFF78_RS13180	COG0742	ribosomal rna small subunit methyltransferase
BFF78_RS13190	COG0326	Molecular chaperone. Has ATPase activity
BFF78_RS13210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BFF78_RS13215	COG0351	phosphomethylpyrimidine kinase
BFF78_RS13235	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFF78_RS13240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BFF78_RS13250	COG1920	GTP binding
BFF78_RS13260	COG0776	regulation of translation
BFF78_RS13270	COG0066	3-isopropylmalate dehydratase activity
BFF78_RS13275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BFF78_RS13280	COG1414	Transcriptional regulator
BFF78_RS13330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFF78_RS13335	COG0179	Fumarylacetoacetate (FAA) hydrolase
BFF78_RS13345	COG5002	protein histidine kinase activity
BFF78_RS13350	COG2018	Roadblock/LC7 domain
BFF78_RS13370	COG2018	Roadblock/LC7 domain
BFF78_RS13390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFF78_RS13395	COG2353	YceI-like domain
BFF78_RS13435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFF78_RS13440	COG0477	Major facilitator Superfamily
BFF78_RS13455	COG2957	Belongs to the agmatine deiminase family
BFF78_RS13460	COG0804	urea catabolic process
BFF78_RS13465	COG0831	urea catabolic process
BFF78_RS13465	COG0832	Belongs to the urease beta subunit family
BFF78_RS13475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFF78_RS13480	COG0473	3-isopropylmalate dehydrogenase activity
BFF78_RS13490	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS13495	COG0506	proline dehydrogenase activity
BFF78_RS13500	COG2508	Transcriptional regulator
BFF78_RS13500	COG2508	Transcriptional regulator
BFF78_RS13510	COG0477	Major facilitator Superfamily
BFF78_RS13515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFF78_RS13520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BFF78_RS13525	COG0440	acetolactate synthase activity
BFF78_RS13535	COG5001	Diguanylate cyclase
BFF78_RS13535	COG3300	MHYT domain
BFF78_RS13545	COG0667	Aldo Keto reductase
BFF78_RS13555	COG2197	response regulator
BFF78_RS13575	COG2409	Drug exporters of the RND superfamily
BFF78_RS13580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BFF78_RS13590	COG0154	amidase activity
BFF78_RS13595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BFF78_RS13620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BFF78_RS13630	COG4221	oxidoreductase activity
BFF78_RS13635	COG1611	Belongs to the LOG family
BFF78_RS13650	COG0482	sulfurtransferase activity
BFF78_RS13675	COG2378	regulation of single-species biofilm formation
BFF78_RS13695	COG4608	Belongs to the ABC transporter superfamily
BFF78_RS13700	COG0444	Belongs to the ABC transporter superfamily
BFF78_RS13735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFF78_RS13740	COG0509	glycine decarboxylation via glycine cleavage system
BFF78_RS13745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFF78_RS13750	COG1760	l-serine dehydratase
BFF78_RS13760	COG0789	Transcriptional regulator
BFF78_RS13775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFF78_RS13785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFF78_RS13790	COG1119	ATPase activity
BFF78_RS13815	COG1024	Enoyl-CoA hydratase
BFF78_RS13825	COG1376	ErfK ybiS ycfS ynhG family protein
BFF78_RS13860	COG1132	(ABC) transporter
BFF78_RS13875	COG1131	(ABC) transporter
BFF78_RS13885	COG4585	Histidine kinase
BFF78_RS13890	COG2197	response regulator
BFF78_RS13895	COG1132	(ABC) transporter
BFF78_RS13900	COG1132	(ABC) transporter
BFF78_RS13935	COG0058	SHG alpha-glucan phosphorylase activity
BFF78_RS13940	COG0366	Alpha amylase catalytic
BFF78_RS13950	COG3281	Trehalose synthase
BFF78_RS13975	COG0477	Major facilitator Superfamily
BFF78_RS13985	COG1301	dicarboxylic acid transport
BFF78_RS13990	COG3290	protein histidine kinase activity
BFF78_RS13995	COG4565	transcriptional regulatory protein
BFF78_RS14005	COG1175	transmembrane transport
BFF78_RS14010	COG0395	ABC-type sugar transport system, permease component
BFF78_RS14020	COG0205	6-phosphofructokinase activity
BFF78_RS14025	COG0857	belongs to the CobB CobQ family
BFF78_RS14025	COG0280	phosphate acetyltransferase
BFF78_RS14030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BFF78_RS14065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS14065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS14125	COG0183	Belongs to the thiolase family
BFF78_RS14180	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BFF78_RS14195	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFF78_RS14225	COG4585	Histidine kinase
BFF78_RS14230	COG2197	response regulator
BFF78_RS14245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BFF78_RS14250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BFF78_RS14255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BFF78_RS14260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BFF78_RS14265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFF78_RS14270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BFF78_RS14275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFF78_RS14295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFF78_RS14300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFF78_RS14310	COG2890	protein-(glutamine-N5) methyltransferase activity
BFF78_RS14315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BFF78_RS14320	COG0254	rRNA binding
BFF78_RS14335	COG0083	homoserine kinase activity
BFF78_RS14350	COG0019	diaminopimelate decarboxylase activity
BFF78_RS14355	COG0018	arginyl-trna synthetase
BFF78_RS14355	COG0018	arginyl-trna synthetase
BFF78_RS14355	COG0018	arginyl-trna synthetase
BFF78_RS14360	COG0745	RESPONSE REGULATOR receiver
BFF78_RS14390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BFF78_RS14395	COG3285	dna ligase
BFF78_RS14395	COG1793	dna ligase
BFF78_RS14415	COG2205	protein histidine kinase activity
BFF78_RS14420	COG0772	Belongs to the SEDS family
BFF78_RS14460	COG0791	NLP P60 protein
BFF78_RS14460	COG3883	PFAM NLP P60 protein
BFF78_RS14535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BFF78_RS14550	COG0745	RESPONSE REGULATOR receiver
BFF78_RS14555	COG2205	protein histidine kinase activity
BFF78_RS14560	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFF78_RS14560	COG0567	Dehydrogenase, E1 component
BFF78_RS14590	COG0604	alcohol dehydrogenase
BFF78_RS14595	COG0281	malic enzyme
BFF78_RS14600	COG4106	trans-aconitate 2-methyltransferase activity
BFF78_RS14620	COG0577	efflux transmembrane transporter activity
BFF78_RS14620	COG1136	(ABC) transporter
BFF78_RS14625	COG1136	(ABC) transporter
BFF78_RS14630	COG4585	Histidine kinase
BFF78_RS14635	COG2197	response regulator
BFF78_RS14640	COG2197	response regulator
BFF78_RS14675	COG0366	Alpha amylase catalytic
BFF78_RS14740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFF78_RS14745	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BFF78_RS14760	COG2172	sigma factor antagonist activity
BFF78_RS14775	COG1597	lipid kinase activity
BFF78_RS14795	COG0363	glucosamine-6-phosphate deaminase activity
BFF78_RS14800	COG2188	Transcriptional regulator
BFF78_RS14830	COG2124	cytochrome p450
BFF78_RS14840	COG0242	peptide deformylase activity
BFF78_RS14855	COG2199	diguanylate cyclase activity
BFF78_RS14855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BFF78_RS14860	COG5662	AntiSigma factor
BFF78_RS14865	COG1595	DNA-templated transcription, initiation
BFF78_RS14875	COG2135	peptidase activity
BFF78_RS14885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BFF78_RS14890	COG1162	GTPase activity
BFF78_RS14895	COG2076	Multidrug Resistance protein
BFF78_RS14905	COG0483	inositol monophosphate 1-phosphatase activity
BFF78_RS14920	COG0753	catalase activity
BFF78_RS14945	COG1615	UPF0182 protein
BFF78_RS14955	COG3480	Lon protease (S16) C-terminal proteolytic domain
BFF78_RS15005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BFF78_RS15045	COG2816	NAD+ diphosphatase activity
BFF78_RS15050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFF78_RS15110	COG0601	transmembrane transport
BFF78_RS15115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFF78_RS15170	COG1432	Conserved Protein
BFF78_RS15175	COG2095	MarC family integral membrane protein
BFF78_RS15195	COG0598	Magnesium transport protein CorA
BFF78_RS15230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFF78_RS15245	COG1595	DNA-templated transcription, initiation
BFF78_RS15260	COG1024	Enoyl-CoA hydratase
BFF78_RS15270	COG0519	Catalyzes the synthesis of GMP from XMP
BFF78_RS15280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BFF78_RS15285	COG1611	Belongs to the LOG family
BFF78_RS15290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFF78_RS15325	COG2197	response regulator
BFF78_RS15330	COG4585	Histidine kinase
BFF78_RS15340	COG1131	(ABC) transporter
BFF78_RS15355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BFF78_RS15390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BFF78_RS15395	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BFF78_RS15410	COG4608	Belongs to the ABC transporter superfamily
BFF78_RS15415	COG0444	Belongs to the ABC transporter superfamily
BFF78_RS15420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFF78_RS15425	COG0601	transmembrane transport
BFF78_RS15440	COG4166	transmembrane transport
BFF78_RS15450	COG0444	Belongs to the ABC transporter superfamily
BFF78_RS15455	COG4608	Belongs to the ABC transporter superfamily
BFF78_RS15485	COG2226	methyltransferase
BFF78_RS15490	COG4608	Belongs to the ABC transporter superfamily
BFF78_RS15495	COG0444	Belongs to the ABC transporter superfamily
BFF78_RS15500	COG0601	transmembrane transport
BFF78_RS15505	COG4166	transmembrane transport
BFF78_RS15510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFF78_RS15535	COG1053	succinate dehydrogenase
BFF78_RS15585	COG2814	Major facilitator Superfamily
BFF78_RS15590	COG0473	3-isopropylmalate dehydrogenase activity
BFF78_RS15600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS15615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFF78_RS15645	COG0475	glutathione-regulated potassium exporter activity
BFF78_RS15650	COG1595	DNA-templated transcription, initiation
BFF78_RS15660	COG0477	Major facilitator Superfamily
BFF78_RS15675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BFF78_RS15695	COG1022	Amp-dependent synthetase and ligase
BFF78_RS15700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFF78_RS15715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS15725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFF78_RS15740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFF78_RS15745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFF78_RS15750	COG2192	nodulation
BFF78_RS15765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS15765	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BFF78_RS15790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS15795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BFF78_RS15805	COG2890	protein-(glutamine-N5) methyltransferase activity
BFF78_RS15810	COG0012	GTP binding
BFF78_RS15825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BFF78_RS15830	COG1570	exodeoxyribonuclease VII activity
BFF78_RS15835	COG1722	exodeoxyribonuclease VII activity
BFF78_RS15840	COG0778	Nitroreductase
BFF78_RS15865	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFF78_RS15865	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFF78_RS15870	COG0114	fumarate hydratase activity
BFF78_RS15885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFF78_RS15905	COG1136	(ABC) transporter
BFF78_RS15935	COG0450	alkyl hydroperoxide reductase
BFF78_RS15940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS15950	COG0741	lytic transglycosylase activity
BFF78_RS15955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BFF78_RS15960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BFF78_RS15965	COG2226	methyltransferase
BFF78_RS15970	COG2318	DinB family
BFF78_RS15995	COG2885	chlorophyll binding
BFF78_RS16015	COG2197	response regulator
BFF78_RS16020	COG3920	Histidine kinase
BFF78_RS16050	COG2894	cell division
BFF78_RS16070	COG0110	maltose O-acetyltransferase activity
BFF78_RS16080	COG2610	gluconate transmembrane transporter activity
BFF78_RS16085	COG0251	oxidation-reduction process
BFF78_RS16090	COG1414	Transcriptional regulator
BFF78_RS16120	COG0436	Aminotransferase
BFF78_RS16145	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BFF78_RS16155	COG0477	Major facilitator Superfamily
BFF78_RS16160	COG1309	transcriptional regulator
BFF78_RS16190	COG1331	Highly conserved protein containing a thioredoxin domain
BFF78_RS16220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BFF78_RS16230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFF78_RS16260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFF78_RS16265	COG2255	four-way junction helicase activity
BFF78_RS16290	COG0501	Belongs to the peptidase M48B family
BFF78_RS16330	COG1064	alcohol dehydrogenase
BFF78_RS16340	COG1404	Belongs to the peptidase S8 family
BFF78_RS16370	COG2986	histidine ammonia-lyase
BFF78_RS16380	COG1024	Enoyl-CoA hydratase
BFF78_RS16390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BFF78_RS16400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFF78_RS16410	COG0424	maF-like protein
BFF78_RS16420	COG4770	biotin carboxylase activity
BFF78_RS16445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFF78_RS16455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BFF78_RS16460	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS16480	COG1595	DNA-templated transcription, initiation
BFF78_RS16485	COG0745	RESPONSE REGULATOR receiver
BFF78_RS16490	COG2205	protein histidine kinase activity
BFF78_RS16515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BFF78_RS16525	COG0583	DNA-binding transcription factor activity
BFF78_RS16530	COG2814	Major facilitator Superfamily
BFF78_RS16575	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BFF78_RS16575	COG1473	amidohydrolase
BFF78_RS16590	COG2089	acid synthase
BFF78_RS16605	COG1216	Glycosyl transferase, family 2
BFF78_RS16615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BFF78_RS16645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS16645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS16660	COG1595	DNA-templated transcription, initiation
BFF78_RS16690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BFF78_RS16700	COG2009	succinate dehydrogenase
BFF78_RS16710	COG1053	succinate dehydrogenase
BFF78_RS16725	COG1309	transcriptional regulator
BFF78_RS16745	COG1295	ribonuclease BN
BFF78_RS16765	COG0180	Tryptophanyl-tRNA synthetase
BFF78_RS16770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFF78_RS16775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFF78_RS16780	COG0754	glutathionylspermidine amidase activity
BFF78_RS16795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS16800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS16805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS16835	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS16850	COG0477	Major facilitator Superfamily
BFF78_RS16855	COG0039	L-malate dehydrogenase activity
BFF78_RS16865	COG2197	response regulator
BFF78_RS16870	COG4585	Histidine kinase
BFF78_RS16880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BFF78_RS16895	COG0515	serine threonine protein kinase
BFF78_RS16895	COG2815	serine threonine protein kinase
BFF78_RS16920	COG0138	bifunctional purine biosynthesis protein purh
BFF78_RS16960	COG0045	succinate-CoA ligase (ADP-forming) activity
BFF78_RS16975	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BFF78_RS16985	COG0714	Associated with various cellular activities
BFF78_RS17000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS17000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFF78_RS17005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BFF78_RS17040	COG2197	response regulator
BFF78_RS17090	COG0519	Catalyzes the synthesis of GMP from XMP
BFF78_RS17090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BFF78_RS17105	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS17110	COG0515	serine threonine protein kinase
BFF78_RS17115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS17120	COG2815	serine threonine protein kinase
BFF78_RS17120	COG0515	serine threonine protein kinase
BFF78_RS17125	COG0515	serine threonine protein kinase
BFF78_RS17130	COG0515	serine threonine protein kinase
BFF78_RS17130	COG2815	serine threonine protein kinase
BFF78_RS17140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BFF78_RS17155	COG0516	GMP reductase activity
BFF78_RS17165	COG1595	DNA-templated transcription, initiation
BFF78_RS17180	COG0583	DNA-binding transcription factor activity
BFF78_RS17190	COG4221	oxidoreductase activity
BFF78_RS17200	COG0459	protein refolding
BFF78_RS17210	COG0726	polysaccharide deacetylase
BFF78_RS17215	COG0726	polysaccharide deacetylase
BFF78_RS17225	COG4941	Belongs to the sigma-70 factor family
BFF78_RS17235	COG1316	TRANSCRIPTIONal
BFF78_RS17260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BFF78_RS17285	COG0802	atpase or kinase
BFF78_RS17290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS17295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFF78_RS17310	COG0736	holo-[acyl-carrier-protein] synthase activity
BFF78_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS17320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BFF78_RS17325	COG1072	(Pantothenic acid kinase))
BFF78_RS17335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFF78_RS17340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BFF78_RS17355	COG0101	tRNA pseudouridine synthase activity
BFF78_RS17360	COG0203	ribosomal protein L17
BFF78_RS17365	COG0202	RNA polymerase activity
BFF78_RS17370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BFF78_RS17375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BFF78_RS17380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BFF78_RS17385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFF78_RS17395	COG0563	adenylate kinase activity
BFF78_RS17405	COG0200	Binds to the 23S rRNA
BFF78_RS17410	COG1841	ribosomal large subunit assembly
BFF78_RS17415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BFF78_RS17420	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BFF78_RS17425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BFF78_RS17430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BFF78_RS17435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BFF78_RS17440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BFF78_RS17445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BFF78_RS17450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BFF78_RS17455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BFF78_RS17460	COG0255	Belongs to the universal ribosomal protein uL29 family
BFF78_RS17465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BFF78_RS17470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BFF78_RS17475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BFF78_RS17480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BFF78_RS17485	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BFF78_RS17490	COG0089	rRNA binding
BFF78_RS17495	COG0088	Forms part of the polypeptide exit tunnel
BFF78_RS17500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BFF78_RS17505	COG0051	transcription antitermination factor activity, RNA binding
BFF78_RS17535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BFF78_RS17540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFF78_RS17545	COG0049	tRNA binding
BFF78_RS17550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BFF78_RS17555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BFF78_RS17560	COG0085	RNA polymerase activity
BFF78_RS17565	COG0222	ribosome binding
BFF78_RS17580	COG0081	regulation of translation
BFF78_RS17590	COG0250	Participates in transcription elongation, termination and antitermination
BFF78_RS17605	COG0436	Aminotransferase
BFF78_RS17610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BFF78_RS17625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BFF78_RS17645	COG2030	dehydratase
BFF78_RS17650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BFF78_RS17665	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS17675	COG0702	epimerase
BFF78_RS17705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS17715	COG3707	response regulator
BFF78_RS17795	COG1666	GTP binding
BFF78_RS17800	COG2261	transglycosylase associated protein
BFF78_RS17810	COG3304	Inner membrane component domain
BFF78_RS17815	COG0501	Belongs to the peptidase M48B family
BFF78_RS17820	COG1007	ATP synthesis coupled electron transport
BFF78_RS17835	COG0713	ATP synthesis coupled electron transport
BFF78_RS17840	COG0839	Belongs to the complex I subunit 6 family
BFF78_RS17845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS17850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BFF78_RS17855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS17860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS17865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS17875	COG4585	Histidine kinase
BFF78_RS17880	COG2197	response regulator
BFF78_RS17885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BFF78_RS17885	COG0674	pyruvate-flavodoxin oxidoreductase activity
BFF78_RS17890	COG1013	pyruvate-flavodoxin oxidoreductase activity
BFF78_RS17895	COG1733	regulation of RNA biosynthetic process
BFF78_RS17900	COG0702	epimerase
BFF78_RS17930	COG1131	(ABC) transporter
BFF78_RS17950	COG0561	phosphatase activity
BFF78_RS17955	COG0492	ferredoxin-NADP+ reductase activity
BFF78_RS17975	COG2188	Transcriptional regulator
BFF78_RS17995	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BFF78_RS18000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BFF78_RS18005	COG0514	ATP-dependent DNA helicase (RecQ)
BFF78_RS18010	COG1007	ATP synthesis coupled electron transport
BFF78_RS18020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BFF78_RS18025	COG0713	ATP synthesis coupled electron transport
BFF78_RS18035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS18040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BFF78_RS18045	COG1034	ATP synthesis coupled electron transport
BFF78_RS18050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BFF78_RS18060	COG0649	NAD binding
BFF78_RS18065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS18070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFF78_RS18085	COG0242	peptide deformylase activity
BFF78_RS18105	COG2226	methyltransferase
BFF78_RS18115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BFF78_RS18170	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BFF78_RS18210	COG1674	ftsk spoiiie
BFF78_RS18275	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BFF78_RS18285	COG1396	sequence-specific DNA binding
BFF78_RS18305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFF78_RS18340	COG1309	transcriptional regulator
BFF78_RS18355	COG1573	uracil-dna glycosylase
BFF78_RS18360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BFF78_RS18370	COG0163	prenyltransferase activity
BFF78_RS18375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BFF78_RS18380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BFF78_RS18390	COG0583	DNA-binding transcription factor activity
BFF78_RS18395	COG0697	spore germination
BFF78_RS18440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFF78_RS18445	COG1333	cytochrome c biogenesis protein
BFF78_RS18450	COG0785	Cytochrome C biogenesis protein
BFF78_RS18465	COG0406	alpha-ribazole phosphatase activity
BFF78_RS18470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BFF78_RS18510	COG0494	nUDIX hydrolase
BFF78_RS18525	COG1131	(ABC) transporter
BFF78_RS18545	COG1216	Glycosyl transferase, family 2
BFF78_RS18550	COG2815	serine threonine protein kinase
BFF78_RS18550	COG0515	serine threonine protein kinase
BFF78_RS18560	COG2268	Band 7 protein
BFF78_RS18575	COG0583	DNA-binding transcription factor activity
BFF78_RS18590	COG2362	D-Aminopeptidase
BFF78_RS18600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFF78_RS18600	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BFF78_RS18610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFF78_RS18615	COG2205	protein histidine kinase activity
BFF78_RS18635	COG1742	UPF0060 membrane protein
BFF78_RS18645	COG1690	Belongs to the RtcB family
BFF78_RS18665	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BFF78_RS18670	COG0018	arginyl-trna synthetase
BFF78_RS18695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS18700	COG0113	porphobilinogen synthase activity
BFF78_RS18715	COG0758	DNA mediated transformation
BFF78_RS18740	COG1648	precorrin-2 dehydrogenase activity
BFF78_RS18740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BFF78_RS18745	COG0181	hydroxymethylbilane synthase activity
BFF78_RS18750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BFF78_RS18755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BFF78_RS18800	COG0123	including yeast histone deacetylase and acetoin utilization protein
BFF78_RS18840	COG0180	Tryptophanyl-tRNA synthetase
BFF78_RS18845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BFF78_RS18855	COG0842	Transport permease protein
BFF78_RS18855	COG1129	ABC transporter
BFF78_RS18870	COG4991	sh3 domain protein
BFF78_RS18875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFF78_RS18875	COG0515	serine threonine protein kinase
BFF78_RS18880	COG0129	dihydroxy-acid dehydratase activity
BFF78_RS18890	COG1082	Xylose isomerase domain protein TIM barrel
BFF78_RS18895	COG0248	Ppx GppA phosphatase
BFF78_RS18915	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BFF78_RS18930	COG1595	DNA-templated transcription, initiation
BFF78_RS18940	COG0745	RESPONSE REGULATOR receiver
BFF78_RS18945	COG2205	protein histidine kinase activity
BFF78_RS18950	COG0346	lactoylglutathione lyase activity
BFF78_RS19000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BFF78_RS19020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BFF78_RS19030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BFF78_RS19035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BFF78_RS19060	COG2197	response regulator
BFF78_RS19075	COG0649	NAD binding
BFF78_RS19100	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BFF78_RS19100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFF78_RS19115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BFF78_RS19130	COG0302	gtp cyclohydrolase
BFF78_RS19145	COG0037	tRNA processing
BFF78_RS19155	COG2027	D-alanyl-D-alanine carboxypeptidase
BFF78_RS19160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BFF78_RS19175	COG0393	Putative heavy-metal-binding
BFF78_RS19180	COG0789	Transcriptional regulator
BFF78_RS19190	COG0076	glutamate decarboxylase activity
BFF78_RS19210	COG2318	DinB family
BFF78_RS19215	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS19270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFF78_RS19270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFF78_RS19275	COG3903	Transcriptional regulator
BFF78_RS19275	COG3629	intracellular signal transduction
BFF78_RS19315	COG2197	response regulator
BFF78_RS19340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFF78_RS19355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFF78_RS19385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFF78_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS19405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BFF78_RS19425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BFF78_RS19430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BFF78_RS19430	COG1754	DNA topoisomerase type I activity
BFF78_RS19450	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BFF78_RS19455	COG2172	sigma factor antagonist activity
BFF78_RS19460	COG1366	Belongs to the anti-sigma-factor antagonist family
BFF78_RS19465	COG1111	helicase
BFF78_RS19465	COG1205	dead DEAH box helicase
BFF78_RS19525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFF78_RS19540	COG2267	carboxylic ester hydrolase activity
BFF78_RS19570	COG1595	DNA-templated transcription, initiation
BFF78_RS19580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS19600	COG0003	Pfam Anion-transporting ATPase
BFF78_RS19610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFF78_RS19620	COG1408	metallophosphoesterase
BFF78_RS19675	COG1674	ftsk spoiiie
BFF78_RS19740	COG1309	transcriptional regulator
BFF78_RS19750	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS19800	COG2205	protein histidine kinase activity
BFF78_RS19805	COG2814	Major facilitator Superfamily
BFF78_RS19835	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BFF78_RS19840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BFF78_RS19845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BFF78_RS19855	COG0531	amino acid
BFF78_RS19885	COG0701	Predicted permease
BFF78_RS19935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BFF78_RS19940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BFF78_RS19960	COG1802	Transcriptional regulator
BFF78_RS19980	COG0737	Belongs to the 5'-nucleotidase family
BFF78_RS19990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BFF78_RS20010	COG2197	response regulator
BFF78_RS20015	COG4585	Histidine kinase
BFF78_RS20020	COG2197	response regulator
BFF78_RS20025	COG4585	Histidine kinase
BFF78_RS20045	COG3844	kynureninase activity
BFF78_RS20060	COG0477	Major facilitator Superfamily
BFF78_RS20070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BFF78_RS20085	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BFF78_RS20115	COG0542	response to heat
BFF78_RS20150	COG4213	ABC transporter substrate-binding protein
BFF78_RS20255	COG0789	Transcriptional regulator
BFF78_RS20260	COG0484	heat shock protein binding
BFF78_RS20265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFF78_RS20270	COG0443	Heat shock 70 kDa protein
BFF78_RS20275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFF78_RS20280	COG0247	lactate metabolic process
BFF78_RS20280	COG2181	nitrate reductase activity
BFF78_RS20325	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BFF78_RS20330	COG0717	Belongs to the dCTP deaminase family
BFF78_RS20370	COG0702	epimerase
BFF78_RS20380	COG3693	PFAM glycoside hydrolase, family 10
BFF78_RS20390	COG1595	DNA-templated transcription, initiation
BFF78_RS20395	COG1191	sigma factor activity
BFF78_RS20425	COG2267	carboxylic ester hydrolase activity
BFF78_RS20460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFF78_RS20465	COG1316	TRANSCRIPTIONal
BFF78_RS20470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BFF78_RS20475	COG0640	Transcriptional regulator
BFF78_RS20510	COG1278	Cold shock
BFF78_RS20515	COG0513	Belongs to the DEAD box helicase family
BFF78_RS20555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFF78_RS20585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFF78_RS20595	COG2318	DinB family
BFF78_RS20600	COG2197	response regulator
BFF78_RS20605	COG4585	Histidine kinase
BFF78_RS20630	COG1846	Transcriptional regulator
BFF78_RS20650	COG2255	four-way junction helicase activity
BFF78_RS20690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFF78_RS20720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BFF78_RS20740	COG1473	amidohydrolase
BFF78_RS20770	COG1289	transmembrane transporter activity
BFF78_RS20780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFF78_RS20790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BFF78_RS20805	COG1741	Belongs to the pirin family
BFF78_RS20815	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS20820	COG1362	aminopeptidase activity
BFF78_RS20835	COG0662	Cupin 2, conserved barrel domain protein
BFF78_RS20890	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFF78_RS20895	COG0022	dehydrogenase e1 component
BFF78_RS20910	COG0515	serine threonine protein kinase
BFF78_RS20915	COG0515	serine threonine protein kinase
BFF78_RS20930	COG3321	synthase
BFF78_RS20930	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS20930	COG0604	alcohol dehydrogenase
BFF78_RS20960	COG1522	sequence-specific DNA binding
BFF78_RS20965	COG1309	transcriptional regulator
BFF78_RS20970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFF78_RS20995	COG3396	Phenylacetate-CoA oxygenase
BFF78_RS21000	COG3460	Phenylacetate-CoA oxygenase
BFF78_RS21005	COG3396	Phenylacetate-CoA oxygenase
BFF78_RS21010	COG2151	metal-sulfur cluster biosynthetic enzyme
BFF78_RS21015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFF78_RS21040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BFF78_RS21050	COG1716	ATPase activity
BFF78_RS21055	COG1716	ATPase activity
BFF78_RS21070	COG0768	penicillin binding
BFF78_RS21080	COG3764	Sortase (surface protein transpeptidase)
BFF78_RS21085	COG3764	Sortase (surface protein transpeptidase)
BFF78_RS21095	COG3764	Sortase (surface protein transpeptidase)
BFF78_RS21110	COG0705	Rhomboid family
BFF78_RS21140	COG0515	serine threonine protein kinase
BFF78_RS21175	COG4249	Peptidase C14 caspase catalytic subunit p20
BFF78_RS21175	COG2319	Wd-40 repeat
BFF78_RS21200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFF78_RS21205	COG0187	DNA topoisomerase II activity
BFF78_RS21210	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BFF78_RS21215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BFF78_RS21220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BFF78_RS21225	COG0592	DNA-directed DNA polymerase activity
BFF78_RS21230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BFF78_RS21235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BFF78_RS21240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BFF78_RS21245	COG0706	membrane insertase activity
BFF78_RS21255	COG0357	Ribosomal RNA small subunit methyltransferase G
BFF78_RS21260	COG1192	Involved in chromosome partitioning
BFF78_RS21275	COG3118	belongs to the thioredoxin family
BFF78_RS21280	COG0492	ferredoxin-NADP+ reductase activity
BFF78_RS21290	COG1595	DNA-templated transcription, initiation
BFF78_RS21295	COG2815	serine threonine protein kinase
BFF78_RS21295	COG0515	serine threonine protein kinase
BFF78_RS21310	COG0617	tRNA 3'-terminal CCA addition
BFF78_RS21330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFF78_RS21355	COG0360	Binds together with S18 to 16S ribosomal RNA
BFF78_RS21360	COG0629	single-stranded DNA binding
BFF78_RS21365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFF78_RS21370	COG0359	binds to the 23S rRNA
BFF78_RS21380	COG0305	Participates in initiation and elongation during chromosome replication
BFF78_RS21390	COG0456	acetyltransferase
BFF78_RS21400	COG2814	Major facilitator Superfamily
BFF78_RS21435	COG0626	cystathionine gamma-synthase activity
BFF78_RS21440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFF78_RS21445	COG1950	PFAM Membrane protein of
BFF78_RS21450	COG0662	Cupin 2, conserved barrel domain protein
BFF78_RS21475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BFF78_RS21495	COG1609	Transcriptional regulator
BFF78_RS21500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFF78_RS21510	COG1271	oxidase subunit
BFF78_RS21515	COG1294	oxidase, subunit
BFF78_RS21520	COG4988	ABC transporter
BFF78_RS21525	COG0561	phosphatase activity
BFF78_RS21535	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BFF78_RS21555	COG1131	(ABC) transporter
BFF78_RS21580	COG0561	phosphatase activity
BFF78_RS21585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BFF78_RS21595	COG2837	iron assimilation
BFF78_RS21635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS21640	COG0006	proline dipeptidase activity
BFF78_RS21660	COG0653	protein targeting
BFF78_RS21735	COG2188	Transcriptional regulator
BFF78_RS21760	COG1051	belongs to the nudix hydrolase family
BFF78_RS21800	COG1595	DNA-templated transcription, initiation
BFF78_RS21805	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS21810	COG0784	Response regulator, receiver
BFF78_RS21860	COG0583	DNA-binding transcription factor activity
BFF78_RS21875	COG1846	Transcriptional regulator
BFF78_RS21895	COG0745	RESPONSE REGULATOR receiver
BFF78_RS21900	COG2205	protein histidine kinase activity
BFF78_RS21910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFF78_RS21915	COG0477	Major facilitator Superfamily
BFF78_RS21925	COG3467	pyridoxamine 5'-phosphate
BFF78_RS21930	COG2353	YceI-like domain
BFF78_RS21935	COG0477	Major facilitator Superfamily
BFF78_RS21955	COG1191	sigma factor activity
BFF78_RS21960	COG1191	sigma factor activity
BFF78_RS21995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BFF78_RS22050	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS22055	COG1276	copper resistance
BFF78_RS22055	COG2372	response to copper ion
BFF78_RS22065	COG0583	DNA-binding transcription factor activity
BFF78_RS22085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BFF78_RS22095	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFF78_RS22100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BFF78_RS22145	COG4249	Peptidase C14 caspase catalytic subunit p20
BFF78_RS22145	COG2319	Wd-40 repeat
BFF78_RS22215	COG1695	Transcriptional regulator
BFF78_RS22245	COG0151	Belongs to the GarS family
BFF78_RS22260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BFF78_RS22270	COG2197	response regulator
BFF78_RS22305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFF78_RS22310	COG0047	phosphoribosylformylglycinamidine synthase activity
BFF78_RS22315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFF78_RS22335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BFF78_RS22370	COG1643	Atp-dependent helicase
BFF78_RS22410	COG0513	Belongs to the DEAD box helicase family
BFF78_RS22440	COG2197	response regulator
BFF78_RS22450	COG0072	phenylalanine-tRNA ligase activity
BFF78_RS22450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFF78_RS22470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFF78_RS22480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFF78_RS22480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFF78_RS22495	COG0667	Aldo Keto reductase
BFF78_RS22505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BFF78_RS22510	COG0579	oxidoreductase
BFF78_RS22545	COG1252	NADH dehydrogenase
BFF78_RS22635	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS22650	COG0791	NLP P60 protein
BFF78_RS22655	COG0671	phosphoesterase, PA-phosphatase related
BFF78_RS22660	COG0277	FAD linked oxidase domain protein
BFF78_RS22685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BFF78_RS22700	COG0306	phosphate transporter
BFF78_RS22710	COG1937	Protein conserved in bacteria
BFF78_RS22735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BFF78_RS22745	COG3842	ATPase activity
BFF78_RS22750	COG1725	Transcriptional regulator
BFF78_RS22755	COG0456	acetyltransferase
BFF78_RS22765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFF78_RS22780	COG1846	Transcriptional regulator
BFF78_RS22790	COG0745	RESPONSE REGULATOR receiver
BFF78_RS22800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFF78_RS22805	COG1609	Transcriptional regulator
BFF78_RS22810	COG0745	RESPONSE REGULATOR receiver
BFF78_RS22840	COG2897	thiosulfate sulfurtransferase activity
BFF78_RS22885	COG3485	protocatechuate 3,4-dioxygenase
BFF78_RS22915	COG1490	D-aminoacyl-tRNA deacylase activity
BFF78_RS22925	COG4552	Acetyltransferase involved in intracellular survival and related
BFF78_RS22940	COG1802	Transcriptional regulator
BFF78_RS22945	COG0546	phosphoglycolate phosphatase activity
BFF78_RS22960	COG0546	phosphoglycolate phosphatase activity
BFF78_RS22975	COG1309	transcriptional regulator
BFF78_RS22985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BFF78_RS22990	COG1280	lysine exporter protein (LysE YggA)
BFF78_RS22995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS23005	COG1595	DNA-templated transcription, initiation
BFF78_RS23035	COG0791	NLP P60 protein
BFF78_RS23035	COG3883	PFAM NLP P60 protein
BFF78_RS23045	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS23070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS23100	COG0588	phosphoglycerate mutase activity
BFF78_RS23105	COG4974	Belongs to the 'phage' integrase family
BFF78_RS23150	COG2188	Transcriptional regulator
BFF78_RS23200	COG5002	protein histidine kinase activity
BFF78_RS23215	COG1329	Transcriptional regulator
BFF78_RS23220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BFF78_RS23225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BFF78_RS23235	COG0215	cysteine-tRNA ligase activity
BFF78_RS23260	COG3842	ATPase activity
BFF78_RS23300	COG0308	aminopeptidase N
BFF78_RS23320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BFF78_RS23350	COG1105	Belongs to the carbohydrate kinase PfkB family
BFF78_RS23385	COG0463	Glycosyl transferase, family 2
BFF78_RS23405	COG0459	protein refolding
BFF78_RS23435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFF78_RS23465	COG1263	PTS System
BFF78_RS23465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFF78_RS23470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BFF78_RS23475	COG1737	Transcriptional regulator
BFF78_RS23515	COG3973	AAA domain
BFF78_RS23525	COG1061	Type III restriction enzyme res subunit
BFF78_RS23550	COG1278	Cold shock
BFF78_RS23555	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BFF78_RS23560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BFF78_RS23570	COG2814	Major facilitator Superfamily
BFF78_RS23580	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BFF78_RS23595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BFF78_RS23605	COG2252	PERMEase
BFF78_RS23635	COG0667	Aldo Keto reductase
BFF78_RS23675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BFF78_RS23680	COG0277	FAD linked oxidase domain protein
BFF78_RS23695	COG5006	permease, DMT superfamily
BFF78_RS23710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFF78_RS23725	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS23730	COG1024	Enoyl-CoA hydratase
BFF78_RS23735	COG1309	transcriptional regulator
BFF78_RS23750	COG0259	pyridoxamine-phosphate oxidase activity
BFF78_RS23755	COG4821	SIS domain
BFF78_RS23770	COG0596	Alpha beta hydrolase
BFF78_RS23770	COG2945	thiolester hydrolase activity
BFF78_RS23840	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS23850	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS23855	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS23870	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS23875	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS23890	COG2814	Major facilitator Superfamily
BFF78_RS23895	COG2264	protein methyltransferase activity
BFF78_RS23900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFF78_RS23910	COG1024	Enoyl-CoA hydratase
BFF78_RS23920	COG2072	flavoprotein involved in K transport
BFF78_RS23940	COG0259	pyridoxamine-phosphate oxidase activity
BFF78_RS23955	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS23965	COG1280	lysine exporter protein (LysE YggA)
BFF78_RS23970	COG1522	sequence-specific DNA binding
BFF78_RS23975	COG1309	transcriptional regulator
BFF78_RS23985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFF78_RS23985	COG0515	serine threonine protein kinase
BFF78_RS23990	COG1024	Enoyl-CoA hydratase
BFF78_RS24015	COG3903	Transcriptional regulator
BFF78_RS24015	COG3629	intracellular signal transduction
BFF78_RS24040	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BFF78_RS24045	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS24080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BFF78_RS24100	COG0596	Alpha beta hydrolase
BFF78_RS24140	COG1686	Belongs to the peptidase S11 family
BFF78_RS24165	COG0386	Belongs to the glutathione peroxidase family
BFF78_RS24180	COG0330	HflC and HflK could
BFF78_RS24195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFF78_RS24205	COG0640	Transcriptional regulator
BFF78_RS24210	COG2226	methyltransferase
BFF78_RS24225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFF78_RS24230	COG2226	methyltransferase
BFF78_RS24285	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS24290	COG1414	Transcriptional regulator
BFF78_RS24315	COG1846	Transcriptional regulator
BFF78_RS24320	COG3384	dioxygenase
BFF78_RS24325	COG1247	-acetyltransferase
BFF78_RS24335	COG0789	Transcriptional regulator
BFF78_RS24350	COG0477	Major facilitator Superfamily
BFF78_RS24355	COG1349	DNA-binding transcription factor activity
BFF78_RS24405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BFF78_RS24410	COG0477	Major facilitator Superfamily
BFF78_RS24425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BFF78_RS24430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BFF78_RS24440	COG0315	cyclic pyranopterin monophosphate synthase activity
BFF78_RS24445	COG0315	cyclic pyranopterin monophosphate synthase activity
BFF78_RS24445	COG0521	Mo-molybdopterin cofactor biosynthetic process
BFF78_RS24450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFF78_RS24480	COG2072	flavoprotein involved in K transport
BFF78_RS24485	COG2267	carboxylic ester hydrolase activity
BFF78_RS24490	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS24500	COG4946	Tricorn protease homolog
BFF78_RS24500	COG0793	Belongs to the peptidase S41A family
BFF78_RS24510	COG2409	Drug exporters of the RND superfamily
BFF78_RS24515	COG0442	prolyl-tRNA aminoacylation
BFF78_RS24540	COG1764	response to oxidative stress
BFF78_RS24545	COG1846	Transcriptional regulator
BFF78_RS24580	COG3584	3D domain protein
BFF78_RS24580	COG3583	domain protein
BFF78_RS24590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BFF78_RS24595	COG0488	(ABC) transporter
BFF78_RS24635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BFF78_RS24645	COG2197	response regulator
BFF78_RS24655	COG4106	trans-aconitate 2-methyltransferase activity
BFF78_RS24665	COG1309	transcriptional regulator
BFF78_RS24675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BFF78_RS24685	COG0193	aminoacyl-tRNA hydrolase activity
BFF78_RS24690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BFF78_RS24695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFF78_RS24700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BFF78_RS24715	COG4585	Histidine kinase
BFF78_RS24765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFF78_RS24775	COG0477	Major facilitator Superfamily
BFF78_RS24780	COG1136	(ABC) transporter
BFF78_RS24785	COG1136	(ABC) transporter
BFF78_RS24785	COG0577	efflux transmembrane transporter activity
BFF78_RS24845	COG1652	LysM domain
BFF78_RS24855	COG0148	phosphopyruvate hydratase activity
BFF78_RS24875	COG1252	NADH dehydrogenase
BFF78_RS24885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BFF78_RS24890	COG0577	efflux transmembrane transporter activity
BFF78_RS24895	COG1136	(ABC) transporter
BFF78_RS24930	COG0183	Belongs to the thiolase family
BFF78_RS24935	COG2755	lipolytic protein G-D-S-L family
BFF78_RS24955	COG2986	histidine ammonia-lyase
BFF78_RS24995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BFF78_RS25010	COG1228	amidohydrolase
BFF78_RS25020	COG1191	sigma factor activity
BFF78_RS25025	COG1366	Belongs to the anti-sigma-factor antagonist family
BFF78_RS25055	COG3104	oligopeptide transport
BFF78_RS25060	COG0745	RESPONSE REGULATOR receiver
BFF78_RS25065	COG2205	protein histidine kinase activity
BFF78_RS25080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BFF78_RS25095	COG0789	Transcriptional regulator
BFF78_RS25120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BFF78_RS25175	COG2226	methyltransferase
BFF78_RS25215	COG2850	peptidyl-arginine hydroxylation
BFF78_RS25235	COG1316	TRANSCRIPTIONal
BFF78_RS25245	COG1316	TRANSCRIPTIONal
BFF78_RS25250	COG1316	TRANSCRIPTIONal
BFF78_RS25260	COG1316	TRANSCRIPTIONal
BFF78_RS25265	COG1316	TRANSCRIPTIONal
BFF78_RS25295	COG0778	Nitroreductase
BFF78_RS25295	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
BFF78_RS25300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BFF78_RS25345	COG1482	cell wall glycoprotein biosynthetic process
BFF78_RS25355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFF78_RS25355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFF78_RS25355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFF78_RS25360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BFF78_RS25405	COG0714	Associated with various cellular activities
BFF78_RS25425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BFF78_RS25430	COG0745	RESPONSE REGULATOR receiver
BFF78_RS25435	COG5000	phosphorelay sensor kinase activity
BFF78_RS25435	COG5002	protein histidine kinase activity
BFF78_RS25440	COG0823	Involved in the tonB-independent uptake of proteins
BFF78_RS25450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BFF78_RS25455	COG2197	response regulator
BFF78_RS25470	COG0653	protein targeting
BFF78_RS25495	COG2902	Dehydrogenase
BFF78_RS25510	COG1215	transferase activity, transferring glycosyl groups
BFF78_RS25515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BFF78_RS25520	COG1134	teichoic acid transport
BFF78_RS25540	COG1215	transferase activity, transferring glycosyl groups
BFF78_RS25550	COG1846	Transcriptional regulator
BFF78_RS25555	COG1764	response to oxidative stress
BFF78_RS25560	COG1215	transferase activity, transferring glycosyl groups
BFF78_RS25565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BFF78_RS25570	COG1216	Glycosyl transferase, family 2
BFF78_RS25575	COG0395	ABC-type sugar transport system, permease component
BFF78_RS25580	COG1175	transmembrane transport
BFF78_RS25595	COG0515	serine threonine protein kinase
BFF78_RS25600	COG0515	serine threonine protein kinase
BFF78_RS25605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BFF78_RS25620	COG2884	Cell division ATP-binding protein ftsE
BFF78_RS25625	COG2177	Part of the ABC transporter FtsEX involved in
BFF78_RS25630	COG0793	Belongs to the peptidase S41A family
BFF78_RS25635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BFF78_RS25650	COG0583	DNA-binding transcription factor activity
BFF78_RS25660	COG2223	nitrite transmembrane transporter activity
BFF78_RS25680	COG0640	Transcriptional regulator
BFF78_RS25715	COG3973	AAA domain
BFF78_RS25725	COG0776	regulation of translation
BFF78_RS25730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BFF78_RS25735	COG1678	Uncharacterized ACR, COG1678
BFF78_RS25745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BFF78_RS25805	COG0531	amino acid
BFF78_RS25825	COG4948	Mandelate Racemase Muconate Lactonizing
BFF78_RS25840	COG1174	glycine betaine transport
BFF78_RS25845	COG0517	IMP dehydrogenase activity
BFF78_RS25845	COG1125	glycine betaine transport
BFF78_RS25850	COG1174	glycine betaine transport
BFF78_RS25860	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BFF78_RS25870	COG0277	FAD linked oxidase domain protein
BFF78_RS25910	COG1335	isochorismatase
BFF78_RS25920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BFF78_RS25930	COG1113	amino acid transport
BFF78_RS25965	COG1234	tRNA 3'-trailer cleavage
BFF78_RS25970	COG1263	PTS System
BFF78_RS25975	COG1263	PTS System
BFF78_RS25980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFF78_RS25985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BFF78_RS26020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFF78_RS26045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BFF78_RS26055	COG2733	membrane
BFF78_RS26125	COG3764	Sortase (surface protein transpeptidase)
BFF78_RS26140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BFF78_RS26170	COG4702	Belongs to the UPF0303 family
BFF78_RS26175	COG0673	inositol 2-dehydrogenase activity
BFF78_RS26190	COG2188	Transcriptional regulator
BFF78_RS26195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFF78_RS26275	COG3397	chitin binding
BFF78_RS26280	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS26295	COG1126	abc transporter atp-binding protein
BFF78_RS26300	COG0765	amino acid transport
BFF78_RS26305	COG0765	amino acid transport
BFF78_RS26310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFF78_RS26340	COG0154	amidase activity
BFF78_RS26360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS26410	COG0406	alpha-ribazole phosphatase activity
BFF78_RS26435	COG0745	RESPONSE REGULATOR receiver
BFF78_RS26485	COG1595	DNA-templated transcription, initiation
BFF78_RS26495	COG0477	Major facilitator Superfamily
BFF78_RS26505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BFF78_RS26510	COG4977	sequence-specific DNA binding
BFF78_RS26520	COG0589	response to stress
BFF78_RS26530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BFF78_RS26570	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BFF78_RS26595	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS26610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFF78_RS26615	COG1309	transcriptional regulator
BFF78_RS26625	COG1946	Acyl-CoA thioesterase
BFF78_RS26645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFF78_RS26655	COG0028	Belongs to the TPP enzyme family
BFF78_RS26690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFF78_RS26715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BFF78_RS26720	COG1472	Belongs to the glycosyl hydrolase 3 family
BFF78_RS26740	COG0456	acetyltransferase
BFF78_RS26740	COG1846	Transcriptional regulator
BFF78_RS26750	COG1609	Transcriptional regulator
BFF78_RS26755	COG0673	inositol 2-dehydrogenase activity
BFF78_RS26775	COG1222	aaa ATPase
BFF78_RS26790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFF78_RS26795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BFF78_RS26825	COG2409	Drug exporters of the RND superfamily
BFF78_RS26830	COG1063	alcohol dehydrogenase
BFF78_RS26855	COG3718	enzyme involved in inositol metabolism
BFF78_RS26860	COG3962	Belongs to the TPP enzyme family
BFF78_RS26880	COG1131	(ABC) transporter
BFF78_RS26915	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS26985	COG2304	oxidoreductase activity
BFF78_RS27040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BFF78_RS27085	COG0546	phosphoglycolate phosphatase activity
BFF78_RS27125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFF78_RS27145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFF78_RS27150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BFF78_RS27160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS27185	COG1309	transcriptional regulator
BFF78_RS27225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BFF78_RS27235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BFF78_RS27255	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS27290	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS27315	COG0477	Major facilitator Superfamily
BFF78_RS27410	COG0629	single-stranded DNA binding
BFF78_RS27455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFF78_RS27490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFF78_RS27505	COG1486	melibiose metabolic process
BFF78_RS27510	COG0395	ABC-type sugar transport system, permease component
BFF78_RS27515	COG1175	transmembrane transport
BFF78_RS27520	COG1653	transport
BFF78_RS27535	COG0668	transmembrane transport
BFF78_RS27560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS27580	COG1846	Transcriptional regulator
BFF78_RS27675	COG2755	lipolytic protein G-D-S-L family
BFF78_RS27690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BFF78_RS27700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BFF78_RS27705	COG1113	amino acid transport
BFF78_RS27720	COG1116	anion transmembrane transporter activity
BFF78_RS27725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFF78_RS27730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BFF78_RS27735	COG1940	carbohydrate kinase activity
BFF78_RS27750	COG0698	ribose 5-phosphate isomerase
BFF78_RS27755	COG1113	amino acid transport
BFF78_RS27760	COG4552	Acetyltransferase involved in intracellular survival and related
BFF78_RS27775	COG3594	Acyltransferase
BFF78_RS27795	COG0544	peptidyl-prolyl cis-trans isomerase activity
BFF78_RS27800	COG0740	serine-type endopeptidase activity
BFF78_RS27805	COG0740	serine-type endopeptidase activity
BFF78_RS27810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BFF78_RS27820	COG0525	valine-tRNA ligase activity
BFF78_RS27825	COG0285	dihydrofolate synthase activity
BFF78_RS27835	COG0105	UTP biosynthetic process
BFF78_RS27840	COG1077	Cell shape determining protein MreB Mrl
BFF78_RS27860	COG0772	Belongs to the SEDS family
BFF78_RS27950	COG0596	Alpha beta hydrolase
BFF78_RS27960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFF78_RS28015	COG1530	ribonuclease E activity
BFF78_RS28020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BFF78_RS28025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BFF78_RS28030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFF78_RS28035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BFF78_RS28040	COG0463	Glycosyl transferase, family 2
BFF78_RS28040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BFF78_RS28045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BFF78_RS28055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BFF78_RS28070	COG0501	Belongs to the peptidase M48B family
BFF78_RS28075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BFF78_RS28090	COG0588	phosphoglycerate mutase activity
BFF78_RS28110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BFF78_RS28120	COG0495	leucyl-tRNA aminoacylation
BFF78_RS28160	COG0268	Binds directly to 16S ribosomal RNA
BFF78_RS28165	COG0481	GTPase activity
BFF78_RS28195	COG1420	regulation of RNA biosynthetic process
BFF78_RS28200	COG0484	heat shock protein binding
BFF78_RS28225	COG0793	Belongs to the peptidase S41A family
BFF78_RS28225	COG4946	Tricorn protease homolog
BFF78_RS28230	COG0537	adenosine 5'-monophosphoramidase activity
BFF78_RS28235	COG1234	tRNA 3'-trailer cleavage
BFF78_RS28240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BFF78_RS28250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS28255	COG4948	Mandelate Racemase Muconate Lactonizing
BFF78_RS28260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFF78_RS28270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BFF78_RS28330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BFF78_RS28365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFF78_RS28375	COG2409	Drug exporters of the RND superfamily
BFF78_RS28380	COG4585	Histidine kinase
BFF78_RS28385	COG2197	response regulator
BFF78_RS28395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS28400	COG4608	Belongs to the ABC transporter superfamily
BFF78_RS28405	COG0444	Belongs to the ABC transporter superfamily
BFF78_RS28415	COG0747	negative chemotaxis
BFF78_RS28450	COG1381	Involved in DNA repair and RecF pathway recombination
BFF78_RS28455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BFF78_RS28470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BFF78_RS28475	COG1121	(ABC) transporter
BFF78_RS28480	COG0803	Belongs to the bacterial solute-binding protein 9 family
BFF78_RS28480	COG3443	Belongs to the bacterial solute-binding protein 9 family
BFF78_RS28485	COG0423	glycine-tRNA ligase activity
BFF78_RS28495	COG0667	Aldo Keto reductase
BFF78_RS28515	COG0477	Major facilitator Superfamily
BFF78_RS28530	COG0477	Major facilitator Superfamily
BFF78_RS28565	COG1846	Transcriptional regulator
BFF78_RS28565	COG1940	carbohydrate kinase activity
BFF78_RS28570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFF78_RS28570	COG0574	Belongs to the PEP-utilizing enzyme family
BFF78_RS28605	COG2182	Extracellular solute-binding protein
BFF78_RS28610	COG1175	transmembrane transport
BFF78_RS28615	COG0395	ABC-type sugar transport system, permease component
BFF78_RS28625	COG2146	nitrite reductase [NAD(P)H] activity
BFF78_RS28625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BFF78_RS28630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BFF78_RS28665	COG0243	molybdopterin cofactor binding
BFF78_RS28675	COG2949	membrane
BFF78_RS28685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BFF78_RS28695	COG0358	DNA primase activity
BFF78_RS28700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFF78_RS28715	COG1070	Carbohydrate kinase
BFF78_RS28745	COG1487	ribonuclease activity
BFF78_RS28775	COG0667	Aldo Keto reductase
BFF78_RS28785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFF78_RS28790	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS28810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS28815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BFF78_RS28820	COG0512	Glutamine amidotransferase of anthranilate synthase
BFF78_RS28820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFF78_RS28825	COG0287	Prephenate dehydrogenase
BFF78_RS28830	COG1605	Chorismate mutase
BFF78_RS28835	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BFF78_RS28845	COG0475	glutathione-regulated potassium exporter activity
BFF78_RS28860	COG2271	Major facilitator Superfamily
BFF78_RS28870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BFF78_RS28885	COG1077	Cell shape determining protein MreB Mrl
BFF78_RS28895	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS28910	COG0583	DNA-binding transcription factor activity
BFF78_RS28915	COG0300	oxidoreductase activity
BFF78_RS28925	COG1414	Transcriptional regulator
BFF78_RS28930	COG3386	PFAM SMP-30 Gluconolaconase
BFF78_RS28965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFF78_RS28975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BFF78_RS28985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFF78_RS28995	COG4214	carbohydrate transport
BFF78_RS29035	COG1764	response to oxidative stress
BFF78_RS29040	COG2130	NADP-dependent
BFF78_RS29070	COG1309	transcriptional regulator
BFF78_RS29100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFF78_RS29105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFF78_RS29110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFF78_RS29140	COG0789	Transcriptional regulator
BFF78_RS29145	COG0667	Aldo Keto reductase
BFF78_RS29160	COG1309	transcriptional regulator
BFF78_RS29165	COG0477	Major facilitator Superfamily
BFF78_RS29175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFF78_RS29180	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BFF78_RS29225	COG1358	cellular component organization or biogenesis
BFF78_RS29295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFF78_RS29310	COG2378	regulation of single-species biofilm formation
BFF78_RS29340	COG4122	O-methyltransferase activity
BFF78_RS29370	COG0183	Belongs to the thiolase family
BFF78_RS29375	COG2124	cytochrome p450
BFF78_RS29380	COG3619	membrane
BFF78_RS29395	COG3845	ABC transporter
BFF78_RS29465	COG1309	transcriptional regulator
BFF78_RS29470	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS29495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS29505	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFF78_RS29550	COG0477	Major facilitator Superfamily
BFF78_RS29555	COG0183	Belongs to the thiolase family
BFF78_RS29575	COG2197	response regulator
BFF78_RS29585	COG4585	Histidine kinase
BFF78_RS29590	COG2030	dehydratase
BFF78_RS29600	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS29610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BFF78_RS29625	COG0800	Aldolase
BFF78_RS29630	COG3022	response to hydroperoxide
BFF78_RS29635	COG0557	exoribonuclease II activity
BFF78_RS29660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS29670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFF78_RS29675	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS29715	COG0477	Major facilitator Superfamily
BFF78_RS29720	COG1942	4-Oxalocrotonate Tautomerase
BFF78_RS29725	COG2814	Major facilitator Superfamily
BFF78_RS29730	COG0583	DNA-binding transcription factor activity
BFF78_RS29750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFF78_RS29760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFF78_RS29770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BFF78_RS29770	COG0473	3-isopropylmalate dehydrogenase activity
BFF78_RS29775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BFF78_RS29775	COG0473	3-isopropylmalate dehydrogenase activity
BFF78_RS29790	COG2259	Doxx family
BFF78_RS29810	COG2814	Major facilitator Superfamily
BFF78_RS29815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BFF78_RS29890	COG1994	Peptidase M50
BFF78_RS29915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BFF78_RS29920	COG0477	Major facilitator Superfamily
BFF78_RS29935	COG2814	Major facilitator Superfamily
BFF78_RS29975	COG1959	2 iron, 2 sulfur cluster binding
BFF78_RS29985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFF78_RS29985	COG1017	nitric oxide dioxygenase activity
BFF78_RS29990	COG0174	glutamine synthetase
BFF78_RS30015	COG3511	phospholipase C
BFF78_RS30020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BFF78_RS30030	COG1609	Transcriptional regulator
BFF78_RS30040	COG1175	transmembrane transport
BFF78_RS30045	COG3833	ABC-type maltose transport systems, permease component
BFF78_RS30050	COG0366	Alpha amylase catalytic
BFF78_RS30070	COG1309	transcriptional regulator
BFF78_RS30100	COG2197	response regulator
BFF78_RS30115	COG0745	RESPONSE REGULATOR receiver
BFF78_RS30160	COG0501	Belongs to the peptidase M48B family
BFF78_RS30185	COG0174	glutamine synthetase
BFF78_RS30195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFF78_RS30210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BFF78_RS30215	COG0321	lipoyl(octanoyl) transferase activity
BFF78_RS30265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BFF78_RS30275	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFF78_RS30280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFF78_RS30285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BFF78_RS30300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BFF78_RS30315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFF78_RS30315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BFF78_RS30320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BFF78_RS30340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFF78_RS30345	COG2226	methyltransferase
BFF78_RS30370	COG2197	response regulator
BFF78_RS30375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BFF78_RS30395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFF78_RS30405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BFF78_RS30410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFF78_RS30420	COG1376	ErfK ybiS ycfS ynhG family protein
BFF78_RS30430	COG1845	cytochrome c oxidase, subunit III
BFF78_RS30440	COG0723	plastoquinol--plastocyanin reductase activity
BFF78_RS30445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BFF78_RS30450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BFF78_RS30455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFF78_RS30500	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS30525	COG0003	Pfam Anion-transporting ATPase
BFF78_RS30535	COG1940	carbohydrate kinase activity
BFF78_RS30570	COG4585	Histidine kinase
BFF78_RS30580	COG0205	6-phosphofructokinase activity
BFF78_RS30590	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BFF78_RS30595	COG0243	molybdopterin cofactor binding
BFF78_RS30600	COG2193	ferroxidase activity
BFF78_RS30605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BFF78_RS30610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BFF78_RS30615	COG0515	serine threonine protein kinase
BFF78_RS30615	COG2815	serine threonine protein kinase
BFF78_RS30620	COG2022	thiamine diphosphate biosynthetic process
BFF78_RS30630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFF78_RS30630	COG2022	thiamine diphosphate biosynthetic process
BFF78_RS30645	COG0352	thiamine-phosphate diphosphorylase activity
BFF78_RS30665	COG1309	transcriptional regulator
BFF78_RS30685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFF78_RS30705	COG0714	Associated with various cellular activities
BFF78_RS30715	COG0275	rRNA processing
BFF78_RS30730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFF78_RS30740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFF78_RS30745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BFF78_RS30755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BFF78_RS30765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BFF78_RS30780	COG1799	cell septum assembly
BFF78_RS30795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BFF78_RS30805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BFF78_RS30825	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS30860	COG0587	DNA-directed DNA polymerase activity
BFF78_RS30865	COG1432	Conserved Protein
BFF78_RS30905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BFF78_RS30910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFF78_RS30915	COG0131	Imidazoleglycerol-phosphate dehydratase
BFF78_RS30920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BFF78_RS30925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BFF78_RS30930	COG0251	oxidation-reduction process
BFF78_RS30935	COG0107	imidazoleglycerol-phosphate synthase activity
BFF78_RS30950	COG0346	lactoylglutathione lyase activity
BFF78_RS30960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BFF78_RS30985	COG0134	indole-3-glycerol-phosphate synthase activity
BFF78_RS30990	COG0133	tryptophan synthase activity
BFF78_RS30995	COG0159	tryptophan synthase activity
BFF78_RS31005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BFF78_RS31015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFF78_RS31020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFF78_RS31050	COG0067	glutamate synthase
BFF78_RS31050	COG0069	glutamate synthase activity
BFF78_RS31050	COG0070	glutamate synthase
BFF78_RS31065	COG2304	oxidoreductase activity
BFF78_RS31070	COG1309	transcriptional regulator
BFF78_RS31075	COG1846	Transcriptional regulator
BFF78_RS31080	COG0477	Major facilitator Superfamily
BFF78_RS31100	COG1605	Chorismate mutase
BFF78_RS31100	COG0287	Prephenate dehydrogenase
BFF78_RS31145	COG0411	ABC transporter
BFF78_RS31165	COG2050	protein possibly involved in aromatic compounds catabolism
BFF78_RS31200	COG1643	Atp-dependent helicase
BFF78_RS31205	COG2226	methyltransferase
BFF78_RS31210	COG0539	negative regulation of cytoplasmic translation
BFF78_RS31220	COG0237	dephospho-CoA kinase activity
BFF78_RS31240	COG2226	methyltransferase
BFF78_RS31305	COG0402	S-adenosylhomocysteine deaminase activity
BFF78_RS31315	COG1132	(ABC) transporter
BFF78_RS31345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS31350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFF78_RS31365	COG3547	Transposase (IS116 IS110 IS902 family)
BFF78_RS31380	COG0598	Magnesium transport protein CorA
BFF78_RS31385	COG2226	methyltransferase
BFF78_RS31395	COG2313	pseudouridylate synthase activity
BFF78_RS31405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFF78_RS31410	COG0584	glycerophosphoryl diester phosphodiesterase
BFF78_RS31415	COG5001	Diguanylate cyclase
BFF78_RS31415	COG3300	MHYT domain
BFF78_RS31420	COG0556	nucleotide-excision repair
BFF78_RS31440	COG0387	Pfam Sodium calcium exchanger
BFF78_RS31445	COG0477	Major facilitator Superfamily
BFF78_RS31450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BFF78_RS31455	COG1126	abc transporter atp-binding protein
BFF78_RS31460	COG0765	amino acid transport
BFF78_RS31465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFF78_RS31480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BFF78_RS31510	COG0322	excinuclease ABC activity
BFF78_RS31515	COG1660	Displays ATPase and GTPase activities
BFF78_RS31520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BFF78_RS31525	COG1481	regulation of sporulation
BFF78_RS31535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BFF78_RS31540	COG0126	phosphoglycerate kinase activity
BFF78_RS31545	COG0149	triose-phosphate isomerase activity
BFF78_RS31550	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BFF78_RS31565	COG0166	Belongs to the GPI family
BFF78_RS31580	COG0577	efflux transmembrane transporter activity
BFF78_RS31580	COG1136	(ABC) transporter
BFF78_RS31585	COG1695	Transcriptional regulator
BFF78_RS31595	COG1653	transport
BFF78_RS31600	COG0366	Alpha amylase catalytic
BFF78_RS31610	COG1175	transmembrane transport
BFF78_RS31615	COG0395	ABC-type sugar transport system, permease component
BFF78_RS31620	COG0363	glucosamine-6-phosphate deaminase activity
BFF78_RS31635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFF78_RS31645	COG0109	protoheme IX farnesyltransferase activity
BFF78_RS31660	COG1612	heme a metabolic process
BFF78_RS31670	COG1131	(ABC) transporter
BFF78_RS31675	COG2746	aminoglycoside 3-N-acetyltransferase activity
BFF78_RS31690	COG0719	Fe-S assembly protein
BFF78_RS31700	COG0396	ATPase activity
BFF78_RS31705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFF78_RS31710	COG0822	iron-sulfur transferase activity
BFF78_RS31715	COG2151	metal-sulfur cluster biosynthetic enzyme
BFF78_RS31720	COG2076	Multidrug Resistance protein
BFF78_RS31725	COG3226	Transcriptional regulator
BFF78_RS31730	COG2171	N-acyltransferase activity
BFF78_RS31745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS31800	COG1309	transcriptional regulator
BFF78_RS31810	COG1063	alcohol dehydrogenase
BFF78_RS31815	COG0395	ABC-type sugar transport system, permease component
BFF78_RS31830	COG1349	DNA-binding transcription factor activity
BFF78_RS31835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFF78_RS31840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS31865	COG1802	Transcriptional regulator
BFF78_RS31870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFF78_RS31885	COG2252	PERMEase
BFF78_RS31895	COG2197	response regulator
BFF78_RS31900	COG4585	Histidine kinase
BFF78_RS31915	COG1414	Transcriptional regulator
BFF78_RS31945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFF78_RS31950	COG5285	phytanoyl-CoA dioxygenase
BFF78_RS31955	COG1917	Cupin 2, conserved barrel domain protein
BFF78_RS31960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BFF78_RS31965	COG0456	acetyltransferase
BFF78_RS31970	COG2318	DinB family
BFF78_RS31985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BFF78_RS31990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFF78_RS31995	COG0765	amino acid transport
BFF78_RS32065	COG1797	cobyrinic acid a,c-diamide synthase activity
BFF78_RS32085	COG1492	cobalamin metabolic process
BFF78_RS32090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BFF78_RS32110	COG0235	Class ii aldolase
BFF78_RS32130	COG0488	(ABC) transporter
BFF78_RS32140	COG1024	Enoyl-CoA hydratase
BFF78_RS32180	COG3387	PFAM Glycoside hydrolase 15-related
BFF78_RS32195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BFF78_RS32230	COG1063	alcohol dehydrogenase
BFF78_RS32240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFF78_RS32255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFF78_RS32260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BFF78_RS32280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BFF78_RS32340	COG2186	Transcriptional regulator
BFF78_RS32355	COG0588	phosphoglycerate mutase activity
BFF78_RS32360	COG3830	Belongs to the UPF0237 family
BFF78_RS32360	COG0560	Phosphoserine phosphatase
BFF78_RS32370	COG0842	Transport permease protein
BFF78_RS32370	COG1716	ATPase activity
BFF78_RS32370	COG1131	(ABC) transporter
BFF78_RS32380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFF78_RS32395	COG2197	response regulator
BFF78_RS32410	COG1119	ATPase activity
BFF78_RS32430	COG1881	PFAM PEBP family protein
BFF78_RS32440	COG2094	Belongs to the DNA glycosylase MPG family
BFF78_RS32480	COG0647	UMP catabolic process
BFF78_RS32485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFF78_RS32490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFF78_RS32495	COG1120	ATPase activity
BFF78_RS32515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BFF78_RS32520	COG0497	DNA recombination
BFF78_RS32530	COG0297	glycogen (starch) synthase activity
BFF78_RS32545	COG3387	PFAM Glycoside hydrolase 15-related
BFF78_RS32550	COG0504	CTP synthase activity
BFF78_RS32555	COG0494	nUDIX hydrolase
BFF78_RS32565	COG0686	Belongs to the AlaDH PNT family
BFF78_RS32580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BFF78_RS32585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BFF78_RS32590	COG1187	pseudouridine synthase activity
BFF78_RS32595	COG1397	ADP-ribosylglycohydrolase
BFF78_RS32600	COG3541	Predicted nucleotidyltransferase
BFF78_RS32625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BFF78_RS32635	COG1160	GTP binding
BFF78_RS32650	COG1652	LysM domain
BFF78_RS32655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFF78_RS32665	COG0671	phosphoesterase, PA-phosphatase related
BFF78_RS32675	COG0477	Major facilitator Superfamily
BFF78_RS32680	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS32685	COG1799	cell septum assembly
BFF78_RS32715	COG0587	DNA-directed DNA polymerase activity
BFF78_RS32725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BFF78_RS32725	COG0662	Cupin 2, conserved barrel domain protein
BFF78_RS32755	COG2226	methyltransferase
BFF78_RS32770	COG1725	Transcriptional regulator
BFF78_RS32795	COG0726	polysaccharide deacetylase
BFF78_RS32805	COG0463	Glycosyl transferase, family 2
BFF78_RS32815	COG2755	lipolytic protein G-D-S-L family
BFF78_RS32840	COG1595	DNA-templated transcription, initiation
BFF78_RS32880	COG2188	Transcriptional regulator
BFF78_RS32885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BFF78_RS32900	COG0243	molybdopterin cofactor binding
BFF78_RS32930	COG0697	spore germination
BFF78_RS32935	COG0640	Transcriptional regulator
BFF78_RS32945	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS32975	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS33005	COG3876	Protein conserved in bacteria
BFF78_RS33015	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS33050	COG2149	membrane
BFF78_RS33055	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BFF78_RS33080	COG1063	alcohol dehydrogenase
BFF78_RS33085	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS33095	COG3265	gluconokinase activity
BFF78_RS33100	COG2186	Transcriptional regulator
BFF78_RS33105	COG3012	SEC-C Motif Domain Protein
BFF78_RS33115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BFF78_RS33115	COG1796	DNA polymerase
BFF78_RS33120	COG0308	aminopeptidase N
BFF78_RS33135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFF78_RS33165	COG0667	Aldo Keto reductase
BFF78_RS33170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS33180	COG0598	Magnesium transport protein CorA
BFF78_RS33200	COG0215	cysteine-tRNA ligase activity
BFF78_RS33210	COG2186	Transcriptional regulator
BFF78_RS33220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BFF78_RS33225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BFF78_RS33230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BFF78_RS33235	COG1414	Transcriptional regulator
BFF78_RS33240	COG1410	methionine synthase
BFF78_RS33240	COG0646	methionine synthase
BFF78_RS33245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFF78_RS33250	COG0747	negative chemotaxis
BFF78_RS33255	COG0747	negative chemotaxis
BFF78_RS33260	COG2197	response regulator
BFF78_RS33270	COG1994	Peptidase M50
BFF78_RS33270	COG0517	IMP dehydrogenase activity
BFF78_RS33290	COG1222	aaa ATPase
BFF78_RS33295	COG4122	O-methyltransferase activity
BFF78_RS33305	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BFF78_RS33310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BFF78_RS33320	COG1609	Transcriptional regulator
BFF78_RS33330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BFF78_RS33365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFF78_RS33370	COG0805	protein transport
BFF78_RS33405	COG0564	pseudouridine synthase activity
BFF78_RS33440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFF78_RS33465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BFF78_RS33475	COG0174	glutamine synthetase
BFF78_RS33530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BFF78_RS33535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BFF78_RS33540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BFF78_RS33550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFF78_RS33555	COG5002	protein histidine kinase activity
BFF78_RS33560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BFF78_RS33565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFF78_RS33565	COG0072	phenylalanine-tRNA ligase activity
BFF78_RS33595	COG1649	PFAM Uncharacterised BCR, COG1649
BFF78_RS33605	COG0697	spore germination
BFF78_RS33610	COG2188	Transcriptional regulator
BFF78_RS33630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BFF78_RS33635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BFF78_RS33640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BFF78_RS33645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFF78_RS33650	COG1438	arginine binding
BFF78_RS33695	COG0745	RESPONSE REGULATOR receiver
BFF78_RS33700	COG2205	protein histidine kinase activity
BFF78_RS33715	COG0137	argininosuccinate synthase activity
BFF78_RS33720	COG0165	Argininosuccinate lyase
BFF78_RS33735	COG0477	Major facilitator Superfamily
BFF78_RS33740	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS33740	COG0204	Acyl-transferase
BFF78_RS33770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BFF78_RS33775	COG2011	ABC-type metal ion transport system permease component
BFF78_RS33780	COG1464	Belongs to the NlpA lipoprotein family
BFF78_RS33795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BFF78_RS33800	COG1648	precorrin-2 dehydrogenase activity
BFF78_RS33800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BFF78_RS33850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFF78_RS33895	COG0596	Alpha beta hydrolase
BFF78_RS33910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFF78_RS33925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BFF78_RS33945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFF78_RS33950	COG1560	Kdo2-lipid A biosynthetic process
BFF78_RS33955	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS33965	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BFF78_RS33970	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BFF78_RS33975	COG0217	transcriptional regulatory protein
BFF78_RS33980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BFF78_RS33985	COG0632	four-way junction helicase activity
BFF78_RS33990	COG2255	four-way junction helicase activity
BFF78_RS34000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFF78_RS34005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFF78_RS34010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BFF78_RS34015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFF78_RS34025	COG1196	nuclear chromosome segregation
BFF78_RS34030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BFF78_RS34040	COG0124	histidyl-tRNA synthetase
BFF78_RS34075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BFF78_RS34095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFF78_RS34100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BFF78_RS34105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BFF78_RS34110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BFF78_RS34115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BFF78_RS34120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BFF78_RS34125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BFF78_RS34135	COG0006	proline dipeptidase activity
BFF78_RS34140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BFF78_RS34145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BFF78_RS34155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BFF78_RS34160	COG0540	Belongs to the ATCase OTCase family
BFF78_RS34165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BFF78_RS34175	COG0505	Belongs to the CarA family
BFF78_RS34180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BFF78_RS34185	COG0167	dihydroorotate dehydrogenase activity
BFF78_RS34190	COG0284	orotidine-5'-phosphate decarboxylase activity
BFF78_RS34200	COG0194	GDP metabolic process
BFF78_RS34215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BFF78_RS34230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BFF78_RS34240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BFF78_RS34245	COG2390	Transcriptional regulator
BFF78_RS34270	COG0531	amino acid
BFF78_RS34280	COG2186	Transcriptional regulator
BFF78_RS34290	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFF78_RS34300	COG3842	ATPase activity
BFF78_RS34305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFF78_RS34340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFF78_RS34360	COG2233	PERMEase
BFF78_RS34375	COG0738	Major facilitator superfamily
BFF78_RS34380	COG1940	carbohydrate kinase activity
BFF78_RS34380	COG1846	Transcriptional regulator
BFF78_RS34400	COG3201	nicotinamide mononucleotide transporter
BFF78_RS34405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFF78_RS34405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFF78_RS34410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BFF78_RS34415	COG0140	phosphoribosyl-ATP diphosphatase activity
BFF78_RS34420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BFF78_RS34475	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS34505	COG1216	Glycosyl transferase, family 2
BFF78_RS34520	COG2270	Major facilitator Superfamily
BFF78_RS34530	COG2364	Membrane
BFF78_RS34535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS34560	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS34565	COG0438	transferase activity, transferring glycosyl groups
BFF78_RS34605	COG2018	Roadblock/LC7 domain
BFF78_RS34620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BFF78_RS34625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BFF78_RS34630	COG3706	GGDEF domain
BFF78_RS34645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BFF78_RS34660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFF78_RS34665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS34680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFF78_RS34715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFF78_RS34755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BFF78_RS34765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFF78_RS34765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFF78_RS34800	COG3835	regulator
BFF78_RS34850	COG0384	phenazine biosynthesis protein PhzF
BFF78_RS34900	COG0697	spore germination
BFF78_RS34945	COG4166	transmembrane transport
BFF78_RS34950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BFF78_RS34965	COG2318	DinB family
BFF78_RS34985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BFF78_RS35010	COG1968	undecaprenyl-diphosphatase activity
BFF78_RS35035	COG0183	Belongs to the thiolase family
BFF78_RS35050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BFF78_RS35065	COG0477	Major facilitator Superfamily
BFF78_RS35185	COG0110	maltose O-acetyltransferase activity
BFF78_RS35210	COG0640	Transcriptional regulator
BFF78_RS35220	COG0531	amino acid
BFF78_RS35225	COG1832	CoA-binding protein
BFF78_RS35240	COG1739	Uncharacterized protein family UPF0029
BFF78_RS35245	COG0420	3'-5' exonuclease activity
BFF78_RS35250	COG0419	ATPase involved in DNA repair
BFF78_RS35255	COG1522	sequence-specific DNA binding
BFF78_RS35290	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS35305	COG0626	cystathionine gamma-synthase activity
BFF78_RS35320	COG0596	Alpha beta hydrolase
BFF78_RS35330	COG1595	DNA-templated transcription, initiation
BFF78_RS35335	COG2188	Transcriptional regulator
BFF78_RS35340	COG1940	carbohydrate kinase activity
BFF78_RS35360	COG3663	DNA glycosylase
BFF78_RS35365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BFF78_RS35405	COG0577	efflux transmembrane transporter activity
BFF78_RS35405	COG1136	(ABC) transporter
BFF78_RS35425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BFF78_RS35430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFF78_RS35435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BFF78_RS35470	COG0740	serine-type endopeptidase activity
BFF78_RS35480	COG0831	urea catabolic process
BFF78_RS35485	COG0832	Belongs to the urease beta subunit family
BFF78_RS35490	COG0804	urea catabolic process
BFF78_RS35500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BFF78_RS35505	COG0829	nickel cation binding
BFF78_RS35520	COG0204	Acyl-transferase
BFF78_RS35535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFF78_RS35540	COG1834	amidinotransferase
BFF78_RS35545	COG1522	sequence-specific DNA binding
BFF78_RS35555	COG0205	6-phosphofructokinase activity
BFF78_RS35560	COG3442	glutamine amidotransferase
BFF78_RS35570	COG0242	peptide deformylase activity
BFF78_RS35580	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS35590	COG2124	cytochrome p450
BFF78_RS35595	COG3424	synthase
BFF78_RS35610	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS35615	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BFF78_RS35620	COG1793	dna ligase
BFF78_RS35640	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS35645	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS35680	COG0586	Pfam SNARE associated Golgi protein
BFF78_RS35685	COG2267	carboxylic ester hydrolase activity
BFF78_RS35690	COG1132	(ABC) transporter
BFF78_RS35740	COG4977	sequence-specific DNA binding
BFF78_RS35745	COG3629	intracellular signal transduction
BFF78_RS35745	COG3903	Transcriptional regulator
BFF78_RS35755	COG0602	queuosine metabolic process
BFF78_RS35760	COG0720	synthase
BFF78_RS35765	COG0302	gtp cyclohydrolase
BFF78_RS35775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BFF78_RS35805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFF78_RS35850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFF78_RS35905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BFF78_RS35910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BFF78_RS35915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BFF78_RS35920	COG0254	rRNA binding
BFF78_RS35930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFF78_RS35945	COG0523	cobalamin synthesis protein
BFF78_RS35980	COG1121	(ABC) transporter
BFF78_RS35985	COG0803	Belongs to the bacterial solute-binding protein 9 family
BFF78_RS35995	COG0003	Pfam Anion-transporting ATPase
BFF78_RS36000	COG0640	Transcriptional regulator
BFF78_RS36015	COG0523	cobalamin synthesis protein
BFF78_RS36050	COG0824	Thioesterase
BFF78_RS36120	COG3629	intracellular signal transduction
BFF78_RS36120	COG3903	Transcriptional regulator
BFF78_RS36145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BFF78_RS36200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFF78_RS36225	COG0252	asparaginase activity
BFF78_RS36230	COG0017	Asparaginyl-tRNA synthetase
BFF78_RS36240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BFF78_RS36250	COG0494	nUDIX hydrolase
BFF78_RS36270	COG0515	serine threonine protein kinase
BFF78_RS36270	COG2815	serine threonine protein kinase
BFF78_RS36350	COG4221	oxidoreductase activity
BFF78_RS36360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFF78_RS36370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFF78_RS36375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BFF78_RS36415	COG1324	tolerance protein
BFF78_RS36425	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS36450	COG1051	belongs to the nudix hydrolase family
BFF78_RS36455	COG1846	Transcriptional regulator
BFF78_RS36455	COG1940	carbohydrate kinase activity
BFF78_RS36465	COG2115	Belongs to the xylose isomerase family
BFF78_RS36530	COG2018	Roadblock/LC7 domain
BFF78_RS36540	COG1946	Acyl-CoA thioesterase
BFF78_RS36555	COG0254	rRNA binding
BFF78_RS36565	COG1132	(ABC) transporter
BFF78_RS36590	COG1132	(ABC) transporter
BFF78_RS36595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BFF78_RS36600	COG2072	flavoprotein involved in K transport
BFF78_RS36610	COG1116	anion transmembrane transporter activity
BFF78_RS36615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFF78_RS36620	COG0432	Pfam Uncharacterised protein family UPF0047
BFF78_RS36640	COG0714	Associated with various cellular activities
BFF78_RS36670	COG0477	Major facilitator Superfamily
BFF78_RS36675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFF78_RS36690	COG2706	6-phosphogluconolactonase activity
BFF78_RS36700	COG2971	BadF BadG BcrA BcrD
BFF78_RS36705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BFF78_RS36725	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS36730	COG3327	negative regulation of DNA-templated transcription, initiation
BFF78_RS36750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BFF78_RS36755	COG1902	pentaerythritol trinitrate reductase activity
BFF78_RS36760	COG0640	Transcriptional regulator
BFF78_RS36765	COG2233	PERMEase
BFF78_RS36825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFF78_RS36840	COG0584	glycerophosphoryl diester phosphodiesterase
BFF78_RS36875	COG0204	Acyl-transferase
BFF78_RS36900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFF78_RS36910	COG0515	serine threonine protein kinase
BFF78_RS36955	COG1660	Displays ATPase and GTPase activities
BFF78_RS36965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFF78_RS36970	COG0445	tRNA wobble uridine modification
BFF78_RS36985	COG4585	Histidine kinase
BFF78_RS36990	COG2197	response regulator
BFF78_RS37030	COG1349	DNA-binding transcription factor activity
BFF78_RS37035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BFF78_RS37045	COG2813	Specifically methylates the guanine in position
BFF78_RS37050	COG3145	DNA-N1-methyladenine dioxygenase activity
BFF78_RS37055	COG1940	carbohydrate kinase activity
BFF78_RS37090	COG1136	(ABC) transporter
BFF78_RS37095	COG0577	efflux transmembrane transporter activity
BFF78_RS37145	COG1349	DNA-binding transcription factor activity
BFF78_RS37180	COG1215	transferase activity, transferring glycosyl groups
BFF78_RS37185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BFF78_RS37210	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS37265	COG0583	DNA-binding transcription factor activity
BFF78_RS37280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BFF78_RS37330	COG1278	Cold shock
BFF78_RS37335	COG0513	Belongs to the DEAD box helicase family
BFF78_RS37445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS37480	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BFF78_RS37540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFF78_RS37545	COG1120	ATPase activity
BFF78_RS37565	COG0367	asparagine synthase
BFF78_RS37655	COG4249	Peptidase C14 caspase catalytic subunit p20
BFF78_RS37655	COG2319	Wd-40 repeat
BFF78_RS37665	COG0515	serine threonine protein kinase
BFF78_RS37910	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BFF78_RS37930	COG1335	isochorismatase
BFF78_RS37940	COG3345	alpha-galactosidase
BFF78_RS37955	COG1733	regulation of RNA biosynthetic process
BFF78_RS37960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS37980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BFF78_RS37995	COG0596	Alpha beta hydrolase
BFF78_RS38000	COG0183	Belongs to the thiolase family
BFF78_RS38005	COG1309	transcriptional regulator
BFF78_RS38010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFF78_RS38020	COG2130	NADP-dependent
BFF78_RS38065	COG2018	Roadblock/LC7 domain
BFF78_RS38085	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS38095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFF78_RS38095	COG3320	Male sterility
BFF78_RS38110	COG1309	transcriptional regulator
BFF78_RS38115	COG2409	Drug exporters of the RND superfamily
BFF78_RS38135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFF78_RS38135	COG2080	2 iron, 2 sulfur cluster binding
BFF78_RS38210	COG0517	IMP dehydrogenase activity
BFF78_RS38215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFF78_RS38220	COG3469	chitinase activity
BFF78_RS38230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BFF78_RS38240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BFF78_RS38300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BFF78_RS38305	COG1993	acr, cog1993
BFF78_RS38310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BFF78_RS38315	COG1968	undecaprenyl-diphosphatase activity
BFF78_RS38320	COG2186	Transcriptional regulator
BFF78_RS38325	COG1113	amino acid transport
BFF78_RS38340	COG2066	Belongs to the glutaminase family
BFF78_RS38350	COG1051	belongs to the nudix hydrolase family
BFF78_RS38360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BFF78_RS38375	COG2226	methyltransferase
BFF78_RS38380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFF78_RS38385	COG3458	cephalosporin-C deacetylase activity
BFF78_RS38400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BFF78_RS38430	COG0714	Associated with various cellular activities
BFF78_RS38465	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFF78_RS38465	COG1902	pentaerythritol trinitrate reductase activity
BFF78_RS38490	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BFF78_RS38495	COG1461	Dihydroxyacetone kinase
BFF78_RS38500	COG2376	Dihydroxyacetone kinase
BFF78_RS38540	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS38550	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BFF78_RS38560	COG1063	alcohol dehydrogenase
BFF78_RS38585	COG0517	IMP dehydrogenase activity
BFF78_RS38585	COG0516	GMP reductase activity
BFF78_RS38595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BFF78_RS38605	COG0515	serine threonine protein kinase
BFF78_RS38605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFF78_RS38615	COG2070	2-Nitropropane dioxygenase
BFF78_RS38640	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS38660	COG0640	Transcriptional regulator
BFF78_RS38670	COG2814	Major facilitator Superfamily
BFF78_RS38695	COG1024	Enoyl-CoA hydratase
BFF78_RS38745	COG0510	thiamine kinase activity
BFF78_RS38765	COG3511	phospholipase C
BFF78_RS38770	COG0673	inositol 2-dehydrogenase activity
BFF78_RS38780	COG2267	carboxylic ester hydrolase activity
BFF78_RS38785	COG0367	asparagine synthase
BFF78_RS38820	COG0789	Transcriptional regulator
BFF78_RS38835	COG3250	beta-galactosidase activity
BFF78_RS38840	COG1940	carbohydrate kinase activity
BFF78_RS38845	COG0531	amino acid
BFF78_RS38915	COG4941	Belongs to the sigma-70 factor family
BFF78_RS38920	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS38945	COG0667	Aldo Keto reductase
BFF78_RS38955	COG1733	regulation of RNA biosynthetic process
BFF78_RS38975	COG0346	lactoylglutathione lyase activity
BFF78_RS38980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BFF78_RS38995	COG0583	DNA-binding transcription factor activity
BFF78_RS39000	COG0667	Aldo Keto reductase
BFF78_RS39025	COG1131	(ABC) transporter
BFF78_RS39025	COG0842	Transport permease protein
BFF78_RS39025	COG1716	ATPase activity
BFF78_RS39035	COG2815	serine threonine protein kinase
BFF78_RS39035	COG0515	serine threonine protein kinase
BFF78_RS39055	COG1191	sigma factor activity
BFF78_RS39060	COG1396	sequence-specific DNA binding
BFF78_RS39065	COG0596	Alpha beta hydrolase
BFF78_RS39080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BFF78_RS39090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFF78_RS39105	COG0328	RNA-DNA hybrid ribonuclease activity
BFF78_RS39110	COG2304	oxidoreductase activity
BFF78_RS39135	COG0583	DNA-binding transcription factor activity
BFF78_RS39150	COG0667	Aldo Keto reductase
BFF78_RS39170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS39175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFF78_RS39175	COG0515	serine threonine protein kinase
BFF78_RS39180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFF78_RS39225	COG2197	response regulator
BFF78_RS39270	COG1278	Cold shock
BFF78_RS39280	COG4221	oxidoreductase activity
BFF78_RS39340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS39360	COG3189	MarR family transcriptional regulator
BFF78_RS39375	COG5002	protein histidine kinase activity
BFF78_RS39445	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BFF78_RS39450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFF78_RS39455	COG3281	Trehalose synthase
BFF78_RS39465	COG0366	Alpha amylase catalytic
BFF78_RS39520	COG0181	hydroxymethylbilane synthase activity
BFF78_RS39530	COG1793	dna ligase
BFF78_RS39540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BFF78_RS39545	COG1414	Transcriptional regulator
BFF78_RS39565	COG5006	permease, DMT superfamily
BFF78_RS39620	COG0667	Aldo Keto reductase
BFF78_RS39625	COG0656	L-ascorbic acid biosynthetic process
BFF78_RS39665	COG0009	L-threonylcarbamoyladenylate synthase
BFF78_RS39715	COG0673	inositol 2-dehydrogenase activity
BFF78_RS39770	COG1733	regulation of RNA biosynthetic process
BFF78_RS39780	COG0583	DNA-binding transcription factor activity
BFF78_RS39785	COG3291	Pkd domain containing protein
BFF78_RS39820	COG1921	L-seryl-tRNASec selenium transferase activity
BFF78_RS39835	COG0709	Synthesizes selenophosphate from selenide and ATP
BFF78_RS39840	COG3383	formate dehydrogenase (NAD+) activity
BFF78_RS39840	COG0243	molybdopterin cofactor binding
BFF78_RS39845	COG0243	molybdopterin cofactor binding
BFF78_RS39845	COG3383	formate dehydrogenase (NAD+) activity
BFF78_RS39855	COG0437	4 iron, 4 sulfur cluster binding
BFF78_RS39875	COG2814	Major facilitator Superfamily
BFF78_RS39885	COG0586	Pfam SNARE associated Golgi protein
BFF78_RS39895	COG0667	Aldo Keto reductase
BFF78_RS39960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BFF78_RS39970	COG1609	Transcriptional regulator
BFF78_RS40005	COG1285	pathogenesis
BFF78_RS40015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BFF78_RS40015	COG1024	Enoyl-CoA hydratase
BFF78_RS40020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BFF78_RS40035	COG0298	carbon dioxide binding
BFF78_RS40050	COG0375	protein maturation
BFF78_RS40110	COG2197	response regulator
BFF78_RS40115	COG4585	Histidine kinase
BFF78_RS40130	COG0701	Predicted permease
BFF78_RS40180	COG0640	Transcriptional regulator
BFF78_RS40185	COG1316	TRANSCRIPTIONal
BFF78_RS40200	COG1090	epimerase
BFF78_RS40205	COG1090	epimerase
BFF78_RS40225	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS40235	COG1228	amidohydrolase
BFF78_RS40265	COG0745	RESPONSE REGULATOR receiver
BFF78_RS40270	COG5002	protein histidine kinase activity
BFF78_RS40285	COG2755	lipolytic protein G-D-S-L family
BFF78_RS40310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BFF78_RS40325	COG2409	Drug exporters of the RND superfamily
BFF78_RS40330	COG0702	epimerase
BFF78_RS40380	COG0300	oxidoreductase activity
BFF78_RS40390	COG1960	acyl-CoA dehydrogenase activity
BFF78_RS40430	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BFF78_RS40445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BFF78_RS40455	COG1984	allophanate hydrolase subunit 2
BFF78_RS40515	COG0277	FAD linked oxidase domain protein
BFF78_RS40585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BFF78_RS40600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BFF78_RS40610	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS40615	COG4175	Glycine betaine
BFF78_RS40615	COG0517	IMP dehydrogenase activity
BFF78_RS40620	COG4176	ABC-type proline glycine betaine transport system permease component
BFF78_RS40635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BFF78_RS40640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFF78_RS40665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BFF78_RS40685	COG1760	l-serine dehydratase
BFF78_RS40690	COG0284	orotidine-5'-phosphate decarboxylase activity
BFF78_RS40695	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS40730	COG3345	alpha-galactosidase
BFF78_RS40735	COG1846	Transcriptional regulator
BFF78_RS40735	COG1940	carbohydrate kinase activity
BFF78_RS40750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFF78_RS40770	COG0745	RESPONSE REGULATOR receiver
BFF78_RS40775	COG2205	protein histidine kinase activity
BFF78_RS40805	COG1012	belongs to the aldehyde dehydrogenase family
BFF78_RS40815	COG3842	ATPase activity
BFF78_RS40820	COG1177	transmembrane transport
BFF78_RS40825	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFF78_RS40855	COG0045	succinate-CoA ligase (ADP-forming) activity
BFF78_RS40855	COG1042	CoA-binding domain protein
BFF78_RS40855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFF78_RS40875	COG1309	transcriptional regulator
BFF78_RS40885	COG4941	Belongs to the sigma-70 factor family
BFF78_RS40890	COG1234	tRNA 3'-trailer cleavage
BFF78_RS40895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFF78_RS40920	COG0586	Pfam SNARE associated Golgi protein
BFF78_RS40925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BFF78_RS40955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFF78_RS40965	COG1088	dTDP-glucose 4,6-dehydratase activity
BFF78_RS40970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BFF78_RS41020	COG0463	Glycosyl transferase, family 2
BFF78_RS41095	COG2205	protein histidine kinase activity
BFF78_RS41105	COG0745	RESPONSE REGULATOR receiver
BFF78_RS41120	COG0019	diaminopimelate decarboxylase activity
BFF78_RS41140	COG4941	Belongs to the sigma-70 factor family
BFF78_RS41185	COG0477	Major facilitator Superfamily
BFF78_RS41250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BFF78_RS41255	COG3290	protein histidine kinase activity
BFF78_RS41280	COG0745	RESPONSE REGULATOR receiver
BFF78_RS41285	COG2205	protein histidine kinase activity
BFF78_RS41325	COG0477	Major facilitator Superfamily
BFF78_RS41335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFF78_RS41380	COG2340	Cysteine-rich secretory protein family
BFF78_RS41390	COG0277	FAD linked oxidase domain protein
BFF78_RS41420	COG1309	transcriptional regulator
BFF78_RS41460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BFF78_RS41505	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS41535	COG1309	transcriptional regulator
BFF78_RS41550	COG4249	Peptidase C14 caspase catalytic subunit p20
BFF78_RS41550	COG2319	Wd-40 repeat
BFF78_RS41565	COG0823	Involved in the tonB-independent uptake of proteins
BFF78_RS41615	COG0588	phosphoglycerate mutase activity
BFF78_RS41620	COG0584	glycerophosphoryl diester phosphodiesterase
BFF78_RS41690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BFF78_RS41725	COG1846	Transcriptional regulator
BFF78_RS41740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFF78_RS41755	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFF78_RS41755	COG0596	Alpha beta hydrolase
BFF78_RS41780	COG0515	serine threonine protein kinase
BFF78_RS41840	COG0484	heat shock protein binding
BFF78_RS41845	COG0443	Heat shock 70 kDa protein
BFF78_RS41850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFF78_RS41880	COG0513	Belongs to the DEAD box helicase family
BFF78_RS41895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BFF78_RS41900	COG1278	Cold shock
BFF78_RS41945	COG0475	glutathione-regulated potassium exporter activity
BFF78_RS41995	COG3328	transposase activity
BFF78_RS42010	COG2315	Protein conserved in bacteria
BFF78_RS42025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFF78_RS42025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BFF78_RS42035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BFF78_RS42040	COG0543	2 iron, 2 sulfur cluster binding
BFF78_RS42040	COG0633	Ferredoxin
BFF78_RS42050	COG0473	3-isopropylmalate dehydrogenase activity
BFF78_RS42050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BFF78_RS42055	COG0604	alcohol dehydrogenase
BFF78_RS42625	COG1522	sequence-specific DNA binding
BFF78_RS42795	COG4191	Histidine kinase
BFF78_RS42890	COG1132	(ABC) transporter
BFF78_RS42895	COG1132	(ABC) transporter
BFF78_RS42960	COG3345	alpha-galactosidase
BFF78_RS43045	COG1028	Short-chain dehydrogenase reductase Sdr
BFF78_RS43215	COG2860	membrane
BFF78_RS43245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFF78_RS43415	COG0745	RESPONSE REGULATOR receiver
BFF78_RS43475	COG0594	ribonuclease P activity
BFF78_RS43515	COG4585	Histidine kinase
BFF78_RS43625	COG2835	tetraacyldisaccharide 4'-kinase activity
BFF78_RS43810	COG0515	serine threonine protein kinase
BFF78_RS43935	COG1716	ATPase activity
BFF78_RS44180	COG2340	Cysteine-rich secretory protein family
BFF78_RS44340	COG3903	Transcriptional regulator
BFF78_RS44340	COG3629	intracellular signal transduction
BFF78_RS44350	COG0542	response to heat
BFF78_RS44375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BFF78_RS44730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BFF78_RS44735	COG0460	homoserine dehydrogenase
BFF78_RS44820	COG0659	secondary active sulfate transmembrane transporter activity
BFF78_RS45500	COG0318	PFAM AMP-dependent synthetase and ligase
BFF78_RS45605	COG0604	alcohol dehydrogenase
BFF78_RS45605	COG3321	synthase
BFF78_RS45885	COG2267	carboxylic ester hydrolase activity
BFF78_RS46200	COG0512	Glutamine amidotransferase of anthranilate synthase
BFF78_RS46200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BFF78_RS46570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BFF78_RS46640	COG2267	carboxylic ester hydrolase activity
BFF78_RS46710	COG2267	carboxylic ester hydrolase activity
BFF78_RS47005	COG1555	photosystem II stabilization