locus-tag	class	description
KY5_RS00020	COG0488	(ABC) transporter
KY5_RS00025	COG0488	(ABC) transporter
KY5_RS00045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY5_RS00065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY5_RS00085	COG1032	radical SAM domain protein
KY5_RS00100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KY5_RS00120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KY5_RS00125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS00130	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS00150	COG0477	Major facilitator Superfamily
KY5_RS00175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KY5_RS00230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS00235	COG3619	membrane
KY5_RS00245	COG1335	isochorismatase
KY5_RS00270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY5_RS00275	COG0783	Belongs to the Dps family
KY5_RS00320	COG4106	trans-aconitate 2-methyltransferase activity
KY5_RS00420	COG3594	Acyltransferase
KY5_RS00450	COG2205	protein histidine kinase activity
KY5_RS00470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KY5_RS00500	COG0745	RESPONSE REGULATOR receiver
KY5_RS00530	COG1595	DNA-templated transcription, initiation
KY5_RS00575	COG0596	Alpha beta hydrolase
KY5_RS00585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KY5_RS00590	COG4941	Belongs to the sigma-70 factor family
KY5_RS00595	COG3795	YCII-related domain
KY5_RS00620	COG1113	amino acid transport
KY5_RS00700	COG0300	oxidoreductase activity
KY5_RS00715	COG0784	Response regulator, receiver
KY5_RS00715	COG2205	protein histidine kinase activity
KY5_RS00745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KY5_RS00760	COG1216	Glycosyl transferase, family 2
KY5_RS00770	COG4310	Domain of unknown function (DUF2172)
KY5_RS00785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KY5_RS00840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KY5_RS00845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KY5_RS00860	COG2814	Major facilitator Superfamily
KY5_RS00910	COG2353	YceI-like domain
KY5_RS00915	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS00920	COG1595	DNA-templated transcription, initiation
KY5_RS00925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS00940	COG0577	efflux transmembrane transporter activity
KY5_RS00940	COG1136	(ABC) transporter
KY5_RS00945	COG4585	Histidine kinase
KY5_RS00950	COG2197	response regulator
KY5_RS00970	COG1228	amidohydrolase
KY5_RS00975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KY5_RS00990	COG2080	2 iron, 2 sulfur cluster binding
KY5_RS00995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KY5_RS01000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KY5_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS01045	COG2837	iron assimilation
KY5_RS01110	COG0477	Major facilitator Superfamily
KY5_RS01125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KY5_RS01130	COG3973	AAA domain
KY5_RS01140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KY5_RS01175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS01195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KY5_RS01200	COG2340	Cysteine-rich secretory protein family
KY5_RS01215	COG5564	TIM-barrel signal transduction protein
KY5_RS01225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS01250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KY5_RS01280	COG0395	ABC-type sugar transport system, permease component
KY5_RS01285	COG1175	transmembrane transport
KY5_RS01305	COG0477	Major facilitator Superfamily
KY5_RS01320	COG2197	response regulator
KY5_RS01320	COG3903	Transcriptional regulator
KY5_RS01365	COG1132	(ABC) transporter
KY5_RS01370	COG1132	(ABC) transporter
KY5_RS01375	COG2755	lipolytic protein G-D-S-L family
KY5_RS01395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY5_RS01415	COG0702	epimerase
KY5_RS01420	COG1733	regulation of RNA biosynthetic process
KY5_RS01425	COG2409	Drug exporters of the RND superfamily
KY5_RS01465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS01495	COG1022	Amp-dependent synthetase and ligase
KY5_RS01520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KY5_RS01525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS01525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS01530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KY5_RS01535	COG0022	dehydrogenase e1 component
KY5_RS01550	COG0330	HflC and HflK could
KY5_RS01615	COG2175	clavaminate synthase activity
KY5_RS01625	COG2409	Drug exporters of the RND superfamily
KY5_RS01645	COG4941	Belongs to the sigma-70 factor family
KY5_RS01650	COG0583	DNA-binding transcription factor activity
KY5_RS01665	COG0367	asparagine synthase
KY5_RS01685	COG2814	Major facilitator Superfamily
KY5_RS01690	COG0673	inositol 2-dehydrogenase activity
KY5_RS01710	COG1335	isochorismatase
KY5_RS01715	COG0477	Major facilitator Superfamily
KY5_RS01725	COG1960	acyl-CoA dehydrogenase activity
KY5_RS01735	COG0242	peptide deformylase activity
KY5_RS01745	COG3442	glutamine amidotransferase
KY5_RS01750	COG0205	6-phosphofructokinase activity
KY5_RS01765	COG0204	Acyl-transferase
KY5_RS01775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KY5_RS01800	COG0829	nickel cation binding
KY5_RS01805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KY5_RS01810	COG0830	nickel cation binding
KY5_RS01815	COG0804	urea catabolic process
KY5_RS01820	COG0832	Belongs to the urease beta subunit family
KY5_RS01825	COG0831	urea catabolic process
KY5_RS01830	COG1309	transcriptional regulator
KY5_RS01840	COG0667	Aldo Keto reductase
KY5_RS01845	COG0583	DNA-binding transcription factor activity
KY5_RS01855	COG0477	Major facilitator Superfamily
KY5_RS01865	COG0740	serine-type endopeptidase activity
KY5_RS01875	COG0791	NLP P60 protein
KY5_RS01880	COG1280	lysine exporter protein (LysE YggA)
KY5_RS01885	COG0583	DNA-binding transcription factor activity
KY5_RS01910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KY5_RS01915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KY5_RS01920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KY5_RS01925	COG2226	methyltransferase
KY5_RS01945	COG1136	(ABC) transporter
KY5_RS01950	COG0577	efflux transmembrane transporter activity
KY5_RS01950	COG1136	(ABC) transporter
KY5_RS01960	COG0456	acetyltransferase
KY5_RS01975	COG0488	(ABC) transporter
KY5_RS01990	COG2364	Membrane
KY5_RS02010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KY5_RS02045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KY5_RS02065	COG4585	Histidine kinase
KY5_RS02070	COG2197	response regulator
KY5_RS02075	COG1940	carbohydrate kinase activity
KY5_RS02080	COG2188	Transcriptional regulator
KY5_RS02085	COG1595	DNA-templated transcription, initiation
KY5_RS02095	COG0346	lactoylglutathione lyase activity
KY5_RS02115	COG0626	cystathionine gamma-synthase activity
KY5_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS02145	COG1522	sequence-specific DNA binding
KY5_RS02150	COG0419	ATPase involved in DNA repair
KY5_RS02155	COG0420	3'-5' exonuclease activity
KY5_RS02160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS02185	COG1739	Uncharacterized protein family UPF0029
KY5_RS02230	COG1832	CoA-binding protein
KY5_RS02270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS02285	COG0542	response to heat
KY5_RS02325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KY5_RS02330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KY5_RS02335	COG2080	2 iron, 2 sulfur cluster binding
KY5_RS02365	COG3629	intracellular signal transduction
KY5_RS02365	COG3903	Transcriptional regulator
KY5_RS02370	COG0009	L-threonylcarbamoyladenylate synthase
KY5_RS02390	COG2264	protein methyltransferase activity
KY5_RS02410	COG0069	glutamate synthase activity
KY5_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS02430	COG2175	clavaminate synthase activity
KY5_RS02435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS02440	COG0017	Asparaginyl-tRNA synthetase
KY5_RS02455	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KY5_RS02465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS02475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KY5_RS02485	COG2814	Major facilitator Superfamily
KY5_RS02495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KY5_RS02500	COG0277	FAD linked oxidase domain protein
KY5_RS02525	COG0432	Pfam Uncharacterised protein family UPF0047
KY5_RS02530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY5_RS02535	COG1116	anion transmembrane transporter activity
KY5_RS02540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KY5_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS02555	COG3321	synthase
KY5_RS02555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS02555	COG0300	oxidoreductase activity
KY5_RS02555	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS02565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY5_RS02575	COG2072	flavoprotein involved in K transport
KY5_RS02590	COG1132	(ABC) transporter
KY5_RS02595	COG1846	Transcriptional regulator
KY5_RS02600	COG0277	FAD linked oxidase domain protein
KY5_RS02620	COG1132	(ABC) transporter
KY5_RS02625	COG1132	(ABC) transporter
KY5_RS02630	COG1132	(ABC) transporter
KY5_RS02635	COG1132	(ABC) transporter
KY5_RS02650	COG1946	Acyl-CoA thioesterase
KY5_RS02670	COG2018	Roadblock/LC7 domain
KY5_RS02705	COG2226	methyltransferase
KY5_RS02745	COG3239	Fatty acid desaturase
KY5_RS02750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KY5_RS02775	COG1070	Carbohydrate kinase
KY5_RS02780	COG1940	carbohydrate kinase activity
KY5_RS02800	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS02850	COG4977	sequence-specific DNA binding
KY5_RS02920	COG0142	geranyltranstransferase activity
KY5_RS02945	COG0367	asparagine synthase
KY5_RS02975	COG1733	regulation of RNA biosynthetic process
KY5_RS03000	COG3425	synthase
KY5_RS03030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS03035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY5_RS03055	COG1120	ATPase activity
KY5_RS03060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS03120	COG4249	Peptidase C14 caspase catalytic subunit p20
KY5_RS03120	COG2319	Wd-40 repeat
KY5_RS03185	COG1131	(ABC) transporter
KY5_RS03185	COG1716	ATPase activity
KY5_RS03185	COG0842	Transport permease protein
KY5_RS03190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY5_RS03195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KY5_RS03200	COG2197	response regulator
KY5_RS03205	COG4585	Histidine kinase
KY5_RS03210	COG1136	(ABC) transporter
KY5_RS03210	COG0577	efflux transmembrane transporter activity
KY5_RS03215	COG0577	efflux transmembrane transporter activity
KY5_RS03215	COG1136	(ABC) transporter
KY5_RS03235	COG2124	cytochrome p450
KY5_RS03245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY5_RS03255	COG2366	antibiotic biosynthetic process
KY5_RS03270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS03280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS03310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KY5_RS03315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS03320	COG0512	Glutamine amidotransferase of anthranilate synthase
KY5_RS03330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KY5_RS03350	COG0488	(ABC) transporter
KY5_RS03355	COG0488	(ABC) transporter
KY5_RS03380	COG3250	beta-galactosidase activity
KY5_RS03390	COG0577	efflux transmembrane transporter activity
KY5_RS03405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY5_RS03440	COG1819	glycosyl
KY5_RS03455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KY5_RS03460	COG1120	ATPase activity
KY5_RS03470	COG2188	Transcriptional regulator
KY5_RS03475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KY5_RS03490	COG0366	Alpha amylase catalytic
KY5_RS03495	COG0438	transferase activity, transferring glycosyl groups
KY5_RS03565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY5_RS03585	COG2066	Belongs to the glutaminase family
KY5_RS03590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KY5_RS03620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KY5_RS03640	COG0659	secondary active sulfate transmembrane transporter activity
KY5_RS03655	COG2814	Major facilitator Superfamily
KY5_RS03660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KY5_RS03675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS03700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS03705	COG2124	cytochrome p450
KY5_RS03715	COG0247	lactate metabolic process
KY5_RS03715	COG0277	FAD linked oxidase domain protein
KY5_RS03720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KY5_RS03755	COG0019	diaminopimelate decarboxylase activity
KY5_RS03805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS03820	COG1595	DNA-templated transcription, initiation
KY5_RS03845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KY5_RS03850	COG0588	phosphoglycerate mutase activity
KY5_RS03855	COG1070	Carbohydrate kinase
KY5_RS03860	COG1070	Carbohydrate kinase
KY5_RS03865	COG2814	Major facilitator Superfamily
KY5_RS03870	COG1349	DNA-binding transcription factor activity
KY5_RS03895	COG0444	Belongs to the ABC transporter superfamily
KY5_RS03900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS03905	COG0601	transmembrane transport
KY5_RS03920	COG1960	acyl-CoA dehydrogenase activity
KY5_RS03925	COG1960	acyl-CoA dehydrogenase activity
KY5_RS03940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS03950	COG1024	Enoyl-CoA hydratase
KY5_RS03965	COG1609	Transcriptional regulator
KY5_RS03970	COG0247	lactate metabolic process
KY5_RS03975	COG1139	Iron-sulfur cluster binding protein
KY5_RS03980	COG1556	Lactate utilization protein
KY5_RS03995	COG1174	glycine betaine transport
KY5_RS04000	COG1174	glycine betaine transport
KY5_RS04005	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
KY5_RS04045	COG2376	Dihydroxyacetone kinase
KY5_RS04050	COG1461	Dihydroxyacetone kinase
KY5_RS04105	COG0446	pyridine nucleotide-disulphide oxidoreductase
KY5_RS04105	COG1902	pentaerythritol trinitrate reductase activity
KY5_RS04130	COG2813	Specifically methylates the guanine in position
KY5_RS04170	COG1215	transferase activity, transferring glycosyl groups
KY5_RS04215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY5_RS04230	COG0577	efflux transmembrane transporter activity
KY5_RS04280	COG1940	carbohydrate kinase activity
KY5_RS04305	COG2197	response regulator
KY5_RS04310	COG4585	Histidine kinase
KY5_RS04325	COG0445	tRNA wobble uridine modification
KY5_RS04340	COG1660	Displays ATPase and GTPase activities
KY5_RS04360	COG1116	anion transmembrane transporter activity
KY5_RS04375	COG2205	protein histidine kinase activity
KY5_RS04380	COG1316	TRANSCRIPTIONal
KY5_RS04395	COG1309	transcriptional regulator
KY5_RS04400	COG2814	Major facilitator Superfamily
KY5_RS04405	COG3237	CsbD-like
KY5_RS04410	COG0395	ABC-type sugar transport system, permease component
KY5_RS04425	COG3345	alpha-galactosidase
KY5_RS04450	COG0515	serine threonine protein kinase
KY5_RS04465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KY5_RS04485	COG0204	Acyl-transferase
KY5_RS04520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS04530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS04540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS04545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS04565	COG1064	alcohol dehydrogenase
KY5_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS04590	COG2233	PERMEase
KY5_RS04610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY5_RS04620	COG0596	Alpha beta hydrolase
KY5_RS04625	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS04645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KY5_RS04655	COG0584	glycerophosphoryl diester phosphodiesterase
KY5_RS04685	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS04690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY5_RS04695	COG1846	Transcriptional regulator
KY5_RS04720	COG0671	phosphoesterase, PA-phosphatase related
KY5_RS04735	COG1309	transcriptional regulator
KY5_RS04760	COG0640	Transcriptional regulator
KY5_RS04765	COG1902	pentaerythritol trinitrate reductase activity
KY5_RS04790	COG1940	carbohydrate kinase activity
KY5_RS04805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS04815	COG2040	homocysteine
KY5_RS04825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KY5_RS04865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY5_RS04870	COG0745	RESPONSE REGULATOR receiver
KY5_RS04880	COG0583	DNA-binding transcription factor activity
KY5_RS04885	COG0473	3-isopropylmalate dehydrogenase activity
KY5_RS04905	COG3979	chitinase
KY5_RS04915	COG1349	DNA-binding transcription factor activity
KY5_RS04920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KY5_RS04925	COG0191	fructose-bisphosphate aldolase activity
KY5_RS04930	COG0395	ABC-type sugar transport system, permease component
KY5_RS04940	COG1653	transport
KY5_RS04945	COG1609	Transcriptional regulator
KY5_RS04980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY5_RS05005	COG2319	Wd-40 repeat
KY5_RS05005	COG4249	Peptidase C14 caspase catalytic subunit p20
KY5_RS05010	COG0252	asparaginase activity
KY5_RS05015	COG1522	sequence-specific DNA binding
KY5_RS05025	COG0702	epimerase
KY5_RS05045	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KY5_RS05050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY5_RS05085	COG2272	Belongs to the type-B carboxylesterase lipase family
KY5_RS05090	COG1472	Belongs to the glycosyl hydrolase 3 family
KY5_RS05130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY5_RS05135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KY5_RS05150	COG0183	Belongs to the thiolase family
KY5_RS05160	COG1968	undecaprenyl-diphosphatase activity
KY5_RS05175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KY5_RS05180	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS05230	COG0475	glutathione-regulated potassium exporter activity
KY5_RS05240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS05255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KY5_RS05260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KY5_RS05265	COG1064	alcohol dehydrogenase
KY5_RS05270	COG1309	transcriptional regulator
KY5_RS05305	COG0477	Major facilitator Superfamily
KY5_RS05325	COG2816	NAD+ diphosphatase activity
KY5_RS05335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KY5_RS05375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KY5_RS05425	COG0583	DNA-binding transcription factor activity
KY5_RS05430	COG0697	spore germination
KY5_RS05445	COG0697	spore germination
KY5_RS05465	COG2890	protein-(glutamine-N5) methyltransferase activity
KY5_RS05475	COG1695	Transcriptional regulator
KY5_RS05485	COG1846	Transcriptional regulator
KY5_RS05490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS05495	COG0384	phenazine biosynthesis protein PhzF
KY5_RS05525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY5_RS05525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY5_RS05535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KY5_RS05575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KY5_RS05610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KY5_RS05620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY5_RS05630	COG0494	nUDIX hydrolase
KY5_RS05635	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KY5_RS05645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY5_RS05650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KY5_RS05655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KY5_RS05690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS05700	COG1414	Transcriptional regulator
KY5_RS05715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS05720	COG4638	Rieske (2fe-2S)
KY5_RS05745	COG2814	Major facilitator Superfamily
KY5_RS05750	COG4336	lyase activity
KY5_RS05755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KY5_RS05760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KY5_RS05765	COG1984	allophanate hydrolase subunit 2
KY5_RS05770	COG2755	lipolytic protein G-D-S-L family
KY5_RS05775	COG0438	transferase activity, transferring glycosyl groups
KY5_RS05810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS05815	COG2364	Membrane
KY5_RS05835	COG3030	protein affecting phage T7 exclusion by the F plasmid
KY5_RS05840	COG0463	Glycosyl transferase, family 2
KY5_RS05875	COG1960	acyl-CoA dehydrogenase activity
KY5_RS05885	COG1309	transcriptional regulator
KY5_RS05920	COG1595	DNA-templated transcription, initiation
KY5_RS05930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KY5_RS05930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KY5_RS05955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KY5_RS05960	COG0140	phosphoribosyl-ATP diphosphatase activity
KY5_RS05965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KY5_RS05970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KY5_RS05970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KY5_RS05975	COG3201	nicotinamide mononucleotide transporter
KY5_RS06045	COG0604	alcohol dehydrogenase
KY5_RS06045	COG3321	synthase
KY5_RS06050	COG0747	negative chemotaxis
KY5_RS06060	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KY5_RS06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS06085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS06120	COG2124	cytochrome p450
KY5_RS06130	COG0604	alcohol dehydrogenase
KY5_RS06130	COG3321	synthase
KY5_RS06155	COG0702	epimerase
KY5_RS06160	COG1846	Transcriptional regulator
KY5_RS06160	COG1940	carbohydrate kinase activity
KY5_RS06165	COG0738	Major facilitator superfamily
KY5_RS06170	COG2233	PERMEase
KY5_RS06195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KY5_RS06215	COG0531	amino acid
KY5_RS06235	COG2390	Transcriptional regulator
KY5_RS06240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KY5_RS06245	COG2409	Drug exporters of the RND superfamily
KY5_RS06270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KY5_RS06305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KY5_RS06320	COG0194	GDP metabolic process
KY5_RS06330	COG0284	orotidine-5'-phosphate decarboxylase activity
KY5_RS06335	COG0167	dihydroorotate dehydrogenase activity
KY5_RS06340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KY5_RS06345	COG0505	Belongs to the CarA family
KY5_RS06355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY5_RS06360	COG0540	Belongs to the ATCase OTCase family
KY5_RS06365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KY5_RS06375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KY5_RS06380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KY5_RS06385	COG0006	proline dipeptidase activity
KY5_RS06395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KY5_RS06400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KY5_RS06405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KY5_RS06410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KY5_RS06415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KY5_RS06420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KY5_RS06425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KY5_RS06445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KY5_RS06465	COG1131	(ABC) transporter
KY5_RS06475	COG0124	histidyl-tRNA synthetase
KY5_RS06485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KY5_RS06490	COG1196	nuclear chromosome segregation
KY5_RS06495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KY5_RS06500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KY5_RS06505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KY5_RS06510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KY5_RS06520	COG2255	four-way junction helicase activity
KY5_RS06525	COG0632	four-way junction helicase activity
KY5_RS06530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KY5_RS06535	COG0217	transcriptional regulatory protein
KY5_RS06540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KY5_RS06545	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KY5_RS06555	COG0438	transferase activity, transferring glycosyl groups
KY5_RS06560	COG1560	Kdo2-lipid A biosynthetic process
KY5_RS06565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KY5_RS06595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KY5_RS06610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KY5_RS06680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KY5_RS06680	COG0512	Glutamine amidotransferase of anthranilate synthase
KY5_RS06740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KY5_RS06740	COG1648	precorrin-2 dehydrogenase activity
KY5_RS06745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KY5_RS06760	COG1464	Belongs to the NlpA lipoprotein family
KY5_RS06765	COG1464	Belongs to the NlpA lipoprotein family
KY5_RS06770	COG2011	ABC-type metal ion transport system permease component
KY5_RS06775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KY5_RS06805	COG0584	glycerophosphoryl diester phosphodiesterase
KY5_RS06810	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS06810	COG0204	Acyl-transferase
KY5_RS06815	COG0477	Major facilitator Superfamily
KY5_RS06830	COG0165	Argininosuccinate lyase
KY5_RS06835	COG0137	argininosuccinate synthase activity
KY5_RS06850	COG0385	Bile acid
KY5_RS06855	COG1438	arginine binding
KY5_RS06860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KY5_RS06865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KY5_RS06870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KY5_RS06875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KY5_RS06885	COG4044	May play a role in the intracellular transport of hydrophobic ligands
KY5_RS06910	COG0477	Major facilitator Superfamily
KY5_RS06930	COG0667	Aldo Keto reductase
KY5_RS06960	COG0697	spore germination
KY5_RS06970	COG1649	PFAM Uncharacterised BCR, COG1649
KY5_RS07000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KY5_RS07000	COG0072	phenylalanine-tRNA ligase activity
KY5_RS07005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KY5_RS07010	COG5002	protein histidine kinase activity
KY5_RS07015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KY5_RS07020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KY5_RS07025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KY5_RS07030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KY5_RS07065	COG0560	Phosphoserine phosphatase
KY5_RS07065	COG3830	Belongs to the UPF0237 family
KY5_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS07080	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS07085	COG0174	glutamine synthetase
KY5_RS07095	COG0531	amino acid
KY5_RS07100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KY5_RS07115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KY5_RS07150	COG0517	IMP dehydrogenase activity
KY5_RS07150	COG4175	Glycine betaine
KY5_RS07155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY5_RS07200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS07215	COG0805	protein transport
KY5_RS07220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KY5_RS07240	COG2378	regulation of single-species biofilm formation
KY5_RS07255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KY5_RS07265	COG1609	Transcriptional regulator
KY5_RS07270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KY5_RS07275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KY5_RS07290	COG4122	O-methyltransferase activity
KY5_RS07295	COG1222	aaa ATPase
KY5_RS07320	COG1994	Peptidase M50
KY5_RS07320	COG0517	IMP dehydrogenase activity
KY5_RS07330	COG2197	response regulator
KY5_RS07335	COG0747	negative chemotaxis
KY5_RS07340	COG0747	negative chemotaxis
KY5_RS07345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY5_RS07350	COG0646	methionine synthase
KY5_RS07350	COG1410	methionine synthase
KY5_RS07355	COG1414	Transcriptional regulator
KY5_RS07360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KY5_RS07365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KY5_RS07370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KY5_RS07375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS07380	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KY5_RS07390	COG0235	Class ii aldolase
KY5_RS07400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KY5_RS07400	COG0235	Class ii aldolase
KY5_RS07410	COG3845	ABC transporter
KY5_RS07415	COG4603	Belongs to the binding-protein-dependent transport system permease family
KY5_RS07420	COG1079	Belongs to the binding-protein-dependent transport system permease family
KY5_RS07430	COG0402	S-adenosylhomocysteine deaminase activity
KY5_RS07435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KY5_RS07445	COG0477	Major facilitator Superfamily
KY5_RS07450	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS07455	COG0346	lactoylglutathione lyase activity
KY5_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS07505	COG1846	Transcriptional regulator
KY5_RS07510	COG2186	Transcriptional regulator
KY5_RS07520	COG1404	Belongs to the peptidase S8 family
KY5_RS07520	COG4935	Belongs to the peptidase S8 family
KY5_RS07535	COG0215	cysteine-tRNA ligase activity
KY5_RS07555	COG0598	Magnesium transport protein CorA
KY5_RS07565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS07570	COG0667	Aldo Keto reductase
KY5_RS07575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KY5_RS07600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY5_RS07615	COG1819	glycosyl
KY5_RS07625	COG2124	cytochrome p450
KY5_RS07650	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KY5_RS07655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KY5_RS07660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KY5_RS07675	COG0531	amino acid
KY5_RS07685	COG2205	protein histidine kinase activity
KY5_RS07705	COG0028	Belongs to the TPP enzyme family
KY5_RS07715	COG0753	catalase activity
KY5_RS07720	COG3012	SEC-C Motif Domain Protein
KY5_RS07730	COG3265	gluconokinase activity
KY5_RS07760	COG3573	Dehydrogenase
KY5_RS07780	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KY5_RS07785	COG2149	membrane
KY5_RS07820	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS07830	COG3876	Protein conserved in bacteria
KY5_RS07840	COG0477	Major facilitator Superfamily
KY5_RS07845	COG2318	DinB family
KY5_RS07870	COG0789	Transcriptional regulator
KY5_RS07890	COG1960	acyl-CoA dehydrogenase activity
KY5_RS07900	COG0640	Transcriptional regulator
KY5_RS07955	COG2851	Citrate transporter
KY5_RS07960	COG0243	molybdopterin cofactor binding
KY5_RS07965	COG1309	transcriptional regulator
KY5_RS07970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KY5_RS07975	COG2188	Transcriptional regulator
KY5_RS07985	COG0477	Major facilitator Superfamily
KY5_RS07995	COG2197	response regulator
KY5_RS08040	COG2755	lipolytic protein G-D-S-L family
KY5_RS08055	COG0463	Glycosyl transferase, family 2
KY5_RS08065	COG1649	PFAM Uncharacterised BCR, COG1649
KY5_RS08065	COG0726	polysaccharide deacetylase
KY5_RS08085	COG1725	Transcriptional regulator
KY5_RS08130	COG4565	transcriptional regulatory protein
KY5_RS08155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KY5_RS08160	COG0587	DNA-directed DNA polymerase activity
KY5_RS08180	COG1454	alcohol dehydrogenase
KY5_RS08180	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS08205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS08210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS08215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY5_RS08220	COG1126	abc transporter atp-binding protein
KY5_RS08235	COG0765	amino acid transport
KY5_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY5_RS08250	COG1799	cell septum assembly
KY5_RS08255	COG1960	acyl-CoA dehydrogenase activity
KY5_RS08260	COG0477	Major facilitator Superfamily
KY5_RS08270	COG0671	phosphoesterase, PA-phosphatase related
KY5_RS08280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KY5_RS08295	COG0438	transferase activity, transferring glycosyl groups
KY5_RS08315	COG1137	ATPase activity
KY5_RS08320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KY5_RS08325	COG3583	domain protein
KY5_RS08345	COG1160	GTP binding
KY5_RS08355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KY5_RS08395	COG3541	Predicted nucleotidyltransferase
KY5_RS08405	COG1051	belongs to the nudix hydrolase family
KY5_RS08405	COG1056	cytidyltransferase-related domain
KY5_RS08410	COG1187	pseudouridine synthase activity
KY5_RS08415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KY5_RS08420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KY5_RS08435	COG0686	Belongs to the AlaDH PNT family
KY5_RS08445	COG0494	nUDIX hydrolase
KY5_RS08450	COG0504	CTP synthase activity
KY5_RS08455	COG3387	PFAM Glycoside hydrolase 15-related
KY5_RS08465	COG0297	glycogen (starch) synthase activity
KY5_RS08470	COG0497	DNA recombination
KY5_RS08480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KY5_RS08500	COG1120	ATPase activity
KY5_RS08505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS08510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS08520	COG1132	(ABC) transporter
KY5_RS08520	COG2375	cellular response to nickel ion
KY5_RS08525	COG0647	UMP catabolic process
KY5_RS08555	COG2094	Belongs to the DNA glycosylase MPG family
KY5_RS08565	COG1881	PFAM PEBP family protein
KY5_RS08585	COG1119	ATPase activity
KY5_RS08605	COG2197	response regulator
KY5_RS08620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KY5_RS08630	COG0842	Transport permease protein
KY5_RS08630	COG1716	ATPase activity
KY5_RS08630	COG1131	(ABC) transporter
KY5_RS08640	COG3830	Belongs to the UPF0237 family
KY5_RS08640	COG0560	Phosphoserine phosphatase
KY5_RS08665	COG2186	Transcriptional regulator
KY5_RS08675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KY5_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS08695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KY5_RS08715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KY5_RS08720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY5_RS08740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY5_RS08750	COG1063	alcohol dehydrogenase
KY5_RS08795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KY5_RS08810	COG3387	PFAM Glycoside hydrolase 15-related
KY5_RS08860	COG0488	(ABC) transporter
KY5_RS08890	COG0235	Class ii aldolase
KY5_RS08910	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KY5_RS08915	COG1492	cobalamin metabolic process
KY5_RS08930	COG1797	cobyrinic acid a,c-diamide synthase activity
KY5_RS08960	COG0456	acetyltransferase
KY5_RS08965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KY5_RS08970	COG1917	Cupin 2, conserved barrel domain protein
KY5_RS08975	COG5285	phytanoyl-CoA dioxygenase
KY5_RS08980	COG1902	pentaerythritol trinitrate reductase activity
KY5_RS08985	COG1846	Transcriptional regulator
KY5_RS09010	COG1733	regulation of RNA biosynthetic process
KY5_RS09015	COG0673	inositol 2-dehydrogenase activity
KY5_RS09030	COG1414	Transcriptional regulator
KY5_RS09045	COG4585	Histidine kinase
KY5_RS09050	COG2197	response regulator
KY5_RS09055	COG0768	penicillin binding
KY5_RS09065	COG1695	Transcriptional regulator
KY5_RS09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY5_RS09105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY5_RS09115	COG1349	DNA-binding transcription factor activity
KY5_RS09135	COG1063	alcohol dehydrogenase
KY5_RS09210	COG2329	Antibiotic biosynthesis monooxygenase
KY5_RS09235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY5_RS09245	COG1595	DNA-templated transcription, initiation
KY5_RS09255	COG2171	N-acyltransferase activity
KY5_RS09260	COG3226	Transcriptional regulator
KY5_RS09265	COG2076	Multidrug Resistance protein
KY5_RS09280	COG0822	iron-sulfur transferase activity
KY5_RS09285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY5_RS09290	COG0396	ATPase activity
KY5_RS09300	COG0719	Fe-S assembly protein
KY5_RS09315	COG2746	aminoglycoside 3-N-acetyltransferase activity
KY5_RS09320	COG2116	formate transmembrane transporter activity
KY5_RS09325	COG1131	(ABC) transporter
KY5_RS09365	COG0109	protoheme IX farnesyltransferase activity
KY5_RS09375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KY5_RS09390	COG0363	glucosamine-6-phosphate deaminase activity
KY5_RS09405	COG0166	Belongs to the GPI family
KY5_RS09415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KY5_RS09420	COG0149	triose-phosphate isomerase activity
KY5_RS09425	COG0126	phosphoglycerate kinase activity
KY5_RS09430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KY5_RS09440	COG1481	regulation of sporulation
KY5_RS09445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KY5_RS09450	COG1660	Displays ATPase and GTPase activities
KY5_RS09455	COG0322	excinuclease ABC activity
KY5_RS09465	COG1595	DNA-templated transcription, initiation
KY5_RS09490	COG0723	plastoquinol--plastocyanin reductase activity
KY5_RS09495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY5_RS09505	COG2353	YceI-like domain
KY5_RS09510	COG1024	Enoyl-CoA hydratase
KY5_RS09515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KY5_RS09525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY5_RS09530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KY5_RS09535	COG0477	Major facilitator Superfamily
KY5_RS09540	COG0387	Pfam Sodium calcium exchanger
KY5_RS09560	COG0556	nucleotide-excision repair
KY5_RS09570	COG0584	glycerophosphoryl diester phosphodiesterase
KY5_RS09575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KY5_RS09590	COG2313	pseudouridylate synthase activity
KY5_RS09595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KY5_RS09595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KY5_RS09600	COG2226	methyltransferase
KY5_RS09605	COG0598	Magnesium transport protein CorA
KY5_RS09665	COG0022	dehydrogenase e1 component
KY5_RS09670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KY5_RS09685	COG0402	S-adenosylhomocysteine deaminase activity
KY5_RS09725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KY5_RS09760	COG2267	carboxylic ester hydrolase activity
KY5_RS09820	COG0237	dephospho-CoA kinase activity
KY5_RS09840	COG2226	methyltransferase
KY5_RS09845	COG1643	Atp-dependent helicase
KY5_RS09875	COG2050	protein possibly involved in aromatic compounds catabolism
KY5_RS09930	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KY5_RS09945	COG0737	Belongs to the 5'-nucleotidase family
KY5_RS09965	COG0702	epimerase
KY5_RS09975	COG1605	Chorismate mutase
KY5_RS09975	COG0287	Prephenate dehydrogenase
KY5_RS09990	COG1470	cell adhesion involved in biofilm formation
KY5_RS09990	COG0366	Alpha amylase catalytic
KY5_RS10010	COG1357	PFAM Pentapeptide repeats (8 copies)
KY5_RS10020	COG1278	Cold shock
KY5_RS10025	COG0477	Major facilitator Superfamily
KY5_RS10030	COG1846	Transcriptional regulator
KY5_RS10035	COG2365	Tyrosine phosphatase family
KY5_RS10040	COG2304	oxidoreductase activity
KY5_RS10065	COG0395	ABC-type sugar transport system, permease component
KY5_RS10070	COG1175	transmembrane transport
KY5_RS10085	COG0070	glutamate synthase
KY5_RS10085	COG0069	glutamate synthase activity
KY5_RS10085	COG0067	glutamate synthase
KY5_RS10115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY5_RS10120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY5_RS10130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KY5_RS10140	COG0159	tryptophan synthase activity
KY5_RS10145	COG0133	tryptophan synthase activity
KY5_RS10150	COG0134	indole-3-glycerol-phosphate synthase activity
KY5_RS10170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KY5_RS10175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KY5_RS10200	COG0107	imidazoleglycerol-phosphate synthase activity
KY5_RS10205	COG0251	oxidation-reduction process
KY5_RS10210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KY5_RS10215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KY5_RS10220	COG0131	Imidazoleglycerol-phosphate dehydratase
KY5_RS10225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY5_RS10230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KY5_RS10250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KY5_RS10275	COG1432	Conserved Protein
KY5_RS10285	COG0587	DNA-directed DNA polymerase activity
KY5_RS10340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KY5_RS10355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KY5_RS10370	COG1799	cell septum assembly
KY5_RS10380	COG1496	oxidoreductase activity
KY5_RS10385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KY5_RS10395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KY5_RS10400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KY5_RS10410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KY5_RS10415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KY5_RS10425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KY5_RS10440	COG0275	rRNA processing
KY5_RS10450	COG0714	Associated with various cellular activities
KY5_RS10480	COG1126	abc transporter atp-binding protein
KY5_RS10490	COG1309	transcriptional regulator
KY5_RS10515	COG0352	thiamine-phosphate diphosphorylase activity
KY5_RS10530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS10530	COG2022	thiamine diphosphate biosynthetic process
KY5_RS10540	COG2022	thiamine diphosphate biosynthetic process
KY5_RS10545	COG0515	serine threonine protein kinase
KY5_RS10545	COG2815	serine threonine protein kinase
KY5_RS10550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KY5_RS10560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KY5_RS10565	COG2193	ferroxidase activity
KY5_RS10570	COG0243	molybdopterin cofactor binding
KY5_RS10575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KY5_RS10585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KY5_RS10590	COG0205	6-phosphofructokinase activity
KY5_RS10595	COG2197	response regulator
KY5_RS10600	COG4585	Histidine kinase
KY5_RS10620	COG1595	DNA-templated transcription, initiation
KY5_RS10635	COG1940	carbohydrate kinase activity
KY5_RS10645	COG0003	Pfam Anion-transporting ATPase
KY5_RS10685	COG0791	NLP P60 protein
KY5_RS10715	COG2205	protein histidine kinase activity
KY5_RS10720	COG0745	RESPONSE REGULATOR receiver
KY5_RS10730	COG1929	Belongs to the glycerate kinase type-1 family
KY5_RS10735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY5_RS10740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KY5_RS10745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KY5_RS10750	COG0723	plastoquinol--plastocyanin reductase activity
KY5_RS10755	COG2010	Cytochrome c
KY5_RS10760	COG1845	cytochrome c oxidase, subunit III
KY5_RS10770	COG1376	ErfK ybiS ycfS ynhG family protein
KY5_RS10780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KY5_RS10785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KY5_RS10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY5_RS10820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KY5_RS10825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KY5_RS10830	COG2197	response regulator
KY5_RS10835	COG4585	Histidine kinase
KY5_RS10855	COG2226	methyltransferase
KY5_RS10860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY5_RS10880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KY5_RS10885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KY5_RS10885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KY5_RS10900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KY5_RS10905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KY5_RS10910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY5_RS10915	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY5_RS10925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KY5_RS10985	COG0321	lipoyl(octanoyl) transferase activity
KY5_RS10990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KY5_RS11025	COG0647	UMP catabolic process
KY5_RS11035	COG1285	pathogenesis
KY5_RS11045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KY5_RS11050	COG1120	ATPase activity
KY5_RS11055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS11125	COG0745	RESPONSE REGULATOR receiver
KY5_RS11135	COG2409	Drug exporters of the RND superfamily
KY5_RS11140	COG4585	Histidine kinase
KY5_RS11145	COG2197	response regulator
KY5_RS11180	COG1309	transcriptional regulator
KY5_RS11210	COG1175	transmembrane transport
KY5_RS11215	COG3833	ABC-type maltose transport systems, permease component
KY5_RS11220	COG0366	Alpha amylase catalytic
KY5_RS11225	COG1609	Transcriptional regulator
KY5_RS11235	COG2124	cytochrome p450
KY5_RS11245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KY5_RS11250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KY5_RS11260	COG0174	glutamine synthetase
KY5_RS11265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY5_RS11265	COG1017	nitric oxide dioxygenase activity
KY5_RS11270	COG1959	2 iron, 2 sulfur cluster binding
KY5_RS11290	COG4209	transmembrane transport
KY5_RS11295	COG0395	ABC-type sugar transport system, permease component
KY5_RS11305	COG1609	Transcriptional regulator
KY5_RS11320	COG0531	amino acid
KY5_RS11330	COG2132	Multicopper oxidase
KY5_RS11335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KY5_RS11335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KY5_RS11340	COG2814	Major facilitator Superfamily
KY5_RS11355	COG0477	Major facilitator Superfamily
KY5_RS11360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KY5_RS11385	COG1994	Peptidase M50
KY5_RS11440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY5_RS11445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS11450	COG1120	ATPase activity
KY5_RS11460	COG2837	iron assimilation
KY5_RS11465	COG0672	)-iron permease
KY5_RS11495	COG1834	amidinotransferase
KY5_RS11520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY5_RS11525	COG2814	Major facilitator Superfamily
KY5_RS11530	COG3540	Alkaline phosphatase
KY5_RS11545	COG0384	phenazine biosynthesis protein PhzF
KY5_RS11555	COG2259	Doxx family
KY5_RS11560	COG4106	trans-aconitate 2-methyltransferase activity
KY5_RS11610	COG2197	response regulator
KY5_RS11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS11660	COG1819	glycosyl
KY5_RS11675	COG2124	cytochrome p450
KY5_RS11680	COG1819	glycosyl
KY5_RS11685	COG1819	glycosyl
KY5_RS11695	COG1819	glycosyl
KY5_RS11745	COG0515	serine threonine protein kinase
KY5_RS11850	COG3022	response to hydroperoxide
KY5_RS11855	COG0800	Aldolase
KY5_RS11870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KY5_RS11875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY5_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS11900	COG2030	dehydratase
KY5_RS11905	COG1131	(ABC) transporter
KY5_RS11915	COG4585	Histidine kinase
KY5_RS11920	COG2197	response regulator
KY5_RS11930	COG0183	Belongs to the thiolase family
KY5_RS11935	COG1960	acyl-CoA dehydrogenase activity
KY5_RS11940	COG0477	Major facilitator Superfamily
KY5_RS11950	COG0860	N-Acetylmuramoyl-L-alanine amidase
KY5_RS11960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS11985	COG0438	transferase activity, transferring glycosyl groups
KY5_RS11990	COG1309	transcriptional regulator
KY5_RS11995	COG1132	(ABC) transporter
KY5_RS12000	COG1132	(ABC) transporter
KY5_RS12010	COG0515	serine threonine protein kinase
KY5_RS12045	COG3845	ABC transporter
KY5_RS12065	COG0183	Belongs to the thiolase family
KY5_RS12070	COG2124	cytochrome p450
KY5_RS12090	COG4122	O-methyltransferase activity
KY5_RS12205	COG2353	YceI-like domain
KY5_RS12240	COG0800	Aldolase
KY5_RS12260	COG1358	cellular component organization or biogenesis
KY5_RS12305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KY5_RS12310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY5_RS12325	COG0477	Major facilitator Superfamily
KY5_RS12330	COG1309	transcriptional regulator
KY5_RS12345	COG4585	Histidine kinase
KY5_RS12350	COG2197	response regulator
KY5_RS12365	COG0667	Aldo Keto reductase
KY5_RS12370	COG0789	Transcriptional regulator
KY5_RS12385	COG1741	Belongs to the pirin family
KY5_RS12400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY5_RS12405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS12410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS12435	COG1309	transcriptional regulator
KY5_RS12495	COG1764	response to oxidative stress
KY5_RS12500	COG2130	NADP-dependent
KY5_RS12540	COG4981	capsule polysaccharide biosynthetic process
KY5_RS12565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KY5_RS12580	COG0583	DNA-binding transcription factor activity
KY5_RS12590	COG2855	membrane
KY5_RS12595	COG0596	Alpha beta hydrolase
KY5_RS12615	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS12620	COG1404	Belongs to the peptidase S8 family
KY5_RS12625	COG1077	Cell shape determining protein MreB Mrl
KY5_RS12660	COG1295	ribonuclease BN
KY5_RS12665	COG1982	Orn Lys Arg decarboxylase major
KY5_RS12675	COG0723	plastoquinol--plastocyanin reductase activity
KY5_RS12675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS12705	COG1070	Carbohydrate kinase
KY5_RS12720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KY5_RS12725	COG0358	DNA primase activity
KY5_RS12735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KY5_RS12745	COG2949	membrane
KY5_RS12750	COG0243	molybdopterin cofactor binding
KY5_RS12775	COG2205	protein histidine kinase activity
KY5_RS12785	COG0789	Transcriptional regulator
KY5_RS12810	COG1017	nitric oxide dioxygenase activity
KY5_RS12810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY5_RS12815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS12820	COG2146	nitrite reductase [NAD(P)H] activity
KY5_RS12820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS12830	COG1309	transcriptional regulator
KY5_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS12855	COG1653	transport
KY5_RS12865	COG0395	ABC-type sugar transport system, permease component
KY5_RS12875	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KY5_RS12885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KY5_RS12885	COG0574	Belongs to the PEP-utilizing enzyme family
KY5_RS12890	COG2186	Transcriptional regulator
KY5_RS12900	COG0494	nUDIX hydrolase
KY5_RS12955	COG1674	ftsk spoiiie
KY5_RS13025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS13050	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS13055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KY5_RS13060	COG1846	Transcriptional regulator
KY5_RS13070	COG4689	acetoacetate decarboxylase
KY5_RS13075	COG0174	glutamine synthetase
KY5_RS13100	COG0667	Aldo Keto reductase
KY5_RS13145	COG0423	glycine-tRNA ligase activity
KY5_RS13150	COG0803	Belongs to the bacterial solute-binding protein 9 family
KY5_RS13150	COG3443	Belongs to the bacterial solute-binding protein 9 family
KY5_RS13155	COG1121	(ABC) transporter
KY5_RS13160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KY5_RS13170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KY5_RS13175	COG1381	Involved in DNA repair and RecF pathway recombination
KY5_RS13240	COG0596	Alpha beta hydrolase
KY5_RS13270	COG2186	Transcriptional regulator
KY5_RS13275	COG0747	negative chemotaxis
KY5_RS13285	COG0444	Belongs to the ABC transporter superfamily
KY5_RS13290	COG4608	Belongs to the ABC transporter superfamily
KY5_RS13300	COG2197	response regulator
KY5_RS13305	COG4585	Histidine kinase
KY5_RS13310	COG2409	Drug exporters of the RND superfamily
KY5_RS13320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KY5_RS13335	COG2723	6-phospho-beta-galactosidase activity
KY5_RS13345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KY5_RS13375	COG2315	Protein conserved in bacteria
KY5_RS13385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KY5_RS13395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KY5_RS13395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KY5_RS13400	COG4948	Mandelate Racemase Muconate Lactonizing
KY5_RS13410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KY5_RS13415	COG1234	tRNA 3'-trailer cleavage
KY5_RS13420	COG0537	adenosine 5'-monophosphoramidase activity
KY5_RS13425	COG0793	Belongs to the peptidase S41A family
KY5_RS13425	COG4946	Tricorn protease homolog
KY5_RS13445	COG0484	heat shock protein binding
KY5_RS13450	COG1420	regulation of RNA biosynthetic process
KY5_RS13490	COG0481	GTPase activity
KY5_RS13495	COG0268	Binds directly to 16S ribosomal RNA
KY5_RS13510	COG2353	YceI-like domain
KY5_RS13520	COG1234	tRNA 3'-trailer cleavage
KY5_RS13525	COG1555	photosystem II stabilization
KY5_RS13530	COG1307	EDD domain protein, DegV family
KY5_RS13540	COG0495	leucyl-tRNA aminoacylation
KY5_RS13590	COG0588	phosphoglycerate mutase activity
KY5_RS13595	COG0799	negative regulation of ribosome biogenesis
KY5_RS13605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KY5_RS13620	COG0501	Belongs to the peptidase M48B family
KY5_RS13635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KY5_RS13645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KY5_RS13655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KY5_RS13660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KY5_RS13665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KY5_RS13675	COG1530	ribonuclease E activity
KY5_RS13705	COG0772	Belongs to the SEDS family
KY5_RS13725	COG1077	Cell shape determining protein MreB Mrl
KY5_RS13730	COG0105	UTP biosynthetic process
KY5_RS13740	COG0285	dihydrofolate synthase activity
KY5_RS13745	COG1077	Cell shape determining protein MreB Mrl
KY5_RS13750	COG4585	Histidine kinase
KY5_RS13760	COG2202	Pas domain
KY5_RS13760	COG2205	protein histidine kinase activity
KY5_RS13780	COG0525	valine-tRNA ligase activity
KY5_RS13800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KY5_RS13805	COG0740	serine-type endopeptidase activity
KY5_RS13810	COG0740	serine-type endopeptidase activity
KY5_RS13815	COG0544	peptidyl-prolyl cis-trans isomerase activity
KY5_RS13830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY5_RS13830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY5_RS13835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY5_RS13845	COG3594	Acyltransferase
KY5_RS13860	COG1136	(ABC) transporter
KY5_RS13865	COG0475	glutathione-regulated potassium exporter activity
KY5_RS13880	COG4552	Acetyltransferase involved in intracellular survival and related
KY5_RS13895	COG1113	amino acid transport
KY5_RS13905	COG1268	BioY protein
KY5_RS13910	COG1113	amino acid transport
KY5_RS13915	COG1113	amino acid transport
KY5_RS13920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KY5_RS13930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KY5_RS14000	COG2814	Major facilitator Superfamily
KY5_RS14005	COG0583	DNA-binding transcription factor activity
KY5_RS14035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS14060	COG3291	Pkd domain containing protein
KY5_RS14060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KY5_RS14070	COG0668	transmembrane transport
KY5_RS14075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KY5_RS14085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS14105	COG1940	carbohydrate kinase activity
KY5_RS14105	COG1846	Transcriptional regulator
KY5_RS14115	COG1175	transmembrane transport
KY5_RS14120	COG0395	ABC-type sugar transport system, permease component
KY5_RS14125	COG1486	melibiose metabolic process
KY5_RS14175	COG2346	COG2346, Truncated hemoglobins
KY5_RS14190	COG0577	efflux transmembrane transporter activity
KY5_RS14190	COG1136	(ABC) transporter
KY5_RS14215	COG0629	single-stranded DNA binding
KY5_RS14265	COG5002	protein histidine kinase activity
KY5_RS14270	COG0745	RESPONSE REGULATOR receiver
KY5_RS14305	COG1022	Amp-dependent synthetase and ligase
KY5_RS14310	COG1309	transcriptional regulator
KY5_RS14320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KY5_RS14340	COG2304	oxidoreductase activity
KY5_RS14405	COG0728	peptidoglycan biosynthetic process
KY5_RS14465	COG1316	TRANSCRIPTIONal
KY5_RS14520	COG1131	(ABC) transporter
KY5_RS14540	COG3962	Belongs to the TPP enzyme family
KY5_RS14545	COG3718	enzyme involved in inositol metabolism
KY5_RS14555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY5_RS14605	COG0673	inositol 2-dehydrogenase activity
KY5_RS14620	COG1280	lysine exporter protein (LysE YggA)
KY5_RS14630	COG1472	Belongs to the glycosyl hydrolase 3 family
KY5_RS14660	COG0028	Belongs to the TPP enzyme family
KY5_RS14670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY5_RS14690	COG1946	Acyl-CoA thioesterase
KY5_RS14695	COG1960	acyl-CoA dehydrogenase activity
KY5_RS14700	COG1309	transcriptional regulator
KY5_RS14705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY5_RS14720	COG1960	acyl-CoA dehydrogenase activity
KY5_RS14735	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KY5_RS14765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KY5_RS14775	COG0589	response to stress
KY5_RS14785	COG4977	sequence-specific DNA binding
KY5_RS14790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KY5_RS14850	COG2985	domain, Protein
KY5_RS14870	COG2205	protein histidine kinase activity
KY5_RS14875	COG0745	RESPONSE REGULATOR receiver
KY5_RS14900	COG0588	phosphoglycerate mutase activity
KY5_RS14950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS14980	COG0154	amidase activity
KY5_RS15000	COG0765	amino acid transport
KY5_RS15005	COG1126	abc transporter atp-binding protein
KY5_RS15020	COG0586	Pfam SNARE associated Golgi protein
KY5_RS15025	COG4585	Histidine kinase
KY5_RS15030	COG2201	protein-glutamate methylesterase activity
KY5_RS15040	COG2197	response regulator
KY5_RS15045	COG4585	Histidine kinase
KY5_RS15050	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS15055	COG3397	chitin binding
KY5_RS15075	COG2186	Transcriptional regulator
KY5_RS15145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS15150	COG2188	Transcriptional regulator
KY5_RS15165	COG0673	inositol 2-dehydrogenase activity
KY5_RS15170	COG4702	Belongs to the UPF0303 family
KY5_RS15205	COG0706	membrane insertase activity
KY5_RS15215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY5_RS15225	COG3764	Sortase (surface protein transpeptidase)
KY5_RS15295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KY5_RS15340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KY5_RS15350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KY5_RS15355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY5_RS15360	COG1263	PTS System
KY5_RS15365	COG1263	PTS System
KY5_RS15375	COG1234	tRNA 3'-trailer cleavage
KY5_RS15400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KY5_RS15405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS15420	COG1113	amino acid transport
KY5_RS15430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KY5_RS15440	COG1335	isochorismatase
KY5_RS15475	COG0277	FAD linked oxidase domain protein
KY5_RS15500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KY5_RS15510	COG1174	glycine betaine transport
KY5_RS15515	COG0517	IMP dehydrogenase activity
KY5_RS15515	COG1125	glycine betaine transport
KY5_RS15520	COG1174	glycine betaine transport
KY5_RS15540	COG3480	Lon protease (S16) C-terminal proteolytic domain
KY5_RS15615	COG1404	Belongs to the peptidase S8 family
KY5_RS15640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KY5_RS15655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KY5_RS15665	COG2814	Major facilitator Superfamily
KY5_RS15670	COG0583	DNA-binding transcription factor activity
KY5_RS15675	COG1678	Uncharacterized ACR, COG1678
KY5_RS15680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KY5_RS15685	COG0776	regulation of translation
KY5_RS15695	COG3973	AAA domain
KY5_RS15725	COG2223	nitrite transmembrane transporter activity
KY5_RS15730	COG1846	Transcriptional regulator
KY5_RS15735	COG0697	spore germination
KY5_RS15740	COG2910	NAD(P)H-binding
KY5_RS15765	COG0583	DNA-binding transcription factor activity
KY5_RS15775	COG2027	D-alanyl-D-alanine carboxypeptidase
KY5_RS15785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KY5_RS15790	COG0793	Belongs to the peptidase S41A family
KY5_RS15800	COG2884	Cell division ATP-binding protein ftsE
KY5_RS15815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KY5_RS15820	COG0515	serine threonine protein kinase
KY5_RS15825	COG0515	serine threonine protein kinase
KY5_RS15840	COG1175	transmembrane transport
KY5_RS15845	COG0395	ABC-type sugar transport system, permease component
KY5_RS15850	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY5_RS15850	COG0463	Glycosyl transferase, family 2
KY5_RS15855	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY5_RS15860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KY5_RS15865	COG0463	Glycosyl transferase, family 2
KY5_RS15865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY5_RS15885	COG0438	transferase activity, transferring glycosyl groups
KY5_RS15890	COG0463	Glycosyl transferase, family 2
KY5_RS15890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY5_RS15895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY5_RS15920	COG0577	efflux transmembrane transporter activity
KY5_RS15920	COG1136	(ABC) transporter
KY5_RS15930	COG2197	response regulator
KY5_RS15950	COG1134	teichoic acid transport
KY5_RS15955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY5_RS15955	COG0463	Glycosyl transferase, family 2
KY5_RS15960	COG2902	Dehydrogenase
KY5_RS15990	COG0653	protein targeting
KY5_RS16000	COG3214	Protein conserved in bacteria
KY5_RS16005	COG2197	response regulator
KY5_RS16010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KY5_RS16020	COG0823	Involved in the tonB-independent uptake of proteins
KY5_RS16025	COG5000	phosphorelay sensor kinase activity
KY5_RS16025	COG5002	protein histidine kinase activity
KY5_RS16030	COG0745	RESPONSE REGULATOR receiver
KY5_RS16035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KY5_RS16055	COG0714	Associated with various cellular activities
KY5_RS16095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KY5_RS16100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY5_RS16100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY5_RS16100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY5_RS16110	COG1482	cell wall glycoprotein biosynthetic process
KY5_RS16120	COG2835	tetraacyldisaccharide 4'-kinase activity
KY5_RS16125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY5_RS16130	COG1620	l-lactate permease
KY5_RS16175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KY5_RS16180	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KY5_RS16180	COG0778	Nitroreductase
KY5_RS16205	COG1316	TRANSCRIPTIONal
KY5_RS16215	COG1316	TRANSCRIPTIONal
KY5_RS16235	COG1316	TRANSCRIPTIONal
KY5_RS16260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KY5_RS16290	COG2205	protein histidine kinase activity
KY5_RS16295	COG0745	RESPONSE REGULATOR receiver
KY5_RS16300	COG3104	oligopeptide transport
KY5_RS16335	COG1366	Belongs to the anti-sigma-factor antagonist family
KY5_RS16340	COG1191	sigma factor activity
KY5_RS16345	COG1794	racemase activity, acting on amino acids and derivatives
KY5_RS16395	COG1131	(ABC) transporter
KY5_RS16410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KY5_RS16440	COG2197	response regulator
KY5_RS16445	COG1228	amidohydrolase
KY5_RS16460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KY5_RS16500	COG2986	histidine ammonia-lyase
KY5_RS16510	COG1174	glycine betaine transport
KY5_RS16525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KY5_RS16535	COG4221	oxidoreductase activity
KY5_RS16550	COG2755	lipolytic protein G-D-S-L family
KY5_RS16555	COG0183	Belongs to the thiolase family
KY5_RS16580	COG2814	Major facilitator Superfamily
KY5_RS16590	COG1414	Transcriptional regulator
KY5_RS16600	COG1136	(ABC) transporter
KY5_RS16605	COG1136	(ABC) transporter
KY5_RS16605	COG0577	efflux transmembrane transporter activity
KY5_RS16610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KY5_RS16615	COG1252	NADH dehydrogenase
KY5_RS16640	COG0148	phosphopyruvate hydratase activity
KY5_RS16655	COG2124	cytochrome p450
KY5_RS16730	COG0577	efflux transmembrane transporter activity
KY5_RS16735	COG1136	(ABC) transporter
KY5_RS16740	COG0477	Major facilitator Superfamily
KY5_RS16750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY5_RS16765	COG1316	TRANSCRIPTIONal
KY5_RS16790	COG4585	Histidine kinase
KY5_RS16800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KY5_RS16805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KY5_RS16810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KY5_RS16815	COG0193	aminoacyl-tRNA hydrolase activity
KY5_RS16830	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KY5_RS16855	COG4106	trans-aconitate 2-methyltransferase activity
KY5_RS16860	COG1846	Transcriptional regulator
KY5_RS16865	COG2197	response regulator
KY5_RS16875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KY5_RS16915	COG0488	(ABC) transporter
KY5_RS16925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KY5_RS16930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KY5_RS16940	COG0084	hydrolase, TatD family'
KY5_RS16960	COG0768	penicillin binding
KY5_RS16970	COG0442	prolyl-tRNA aminoacylation
KY5_RS16990	COG1122	ATPase activity
KY5_RS17000	COG0310	cobalt ion transport
KY5_RS17010	COG2409	Drug exporters of the RND superfamily
KY5_RS17020	COG4946	Tricorn protease homolog
KY5_RS17020	COG0793	Belongs to the peptidase S41A family
KY5_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS17035	COG2267	carboxylic ester hydrolase activity
KY5_RS17040	COG2072	flavoprotein involved in K transport
KY5_RS17055	COG0708	Exodeoxyribonuclease III
KY5_RS17065	COG1309	transcriptional regulator
KY5_RS17080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY5_RS17085	COG0521	Mo-molybdopterin cofactor biosynthetic process
KY5_RS17090	COG0315	cyclic pyranopterin monophosphate synthase activity
KY5_RS17100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KY5_RS17105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KY5_RS17110	COG2366	antibiotic biosynthetic process
KY5_RS17115	COG3263	regulation of cellular component size
KY5_RS17130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KY5_RS17140	COG1970	mechanosensitive ion channel activity
KY5_RS17150	COG2223	nitrite transmembrane transporter activity
KY5_RS17155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KY5_RS17165	COG2223	nitrite transmembrane transporter activity
KY5_RS17170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS17170	COG2146	nitrite reductase [NAD(P)H] activity
KY5_RS17185	COG3191	aminopeptidase activity
KY5_RS17205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KY5_RS17205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY5_RS17205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY5_RS17215	COG1349	DNA-binding transcription factor activity
KY5_RS17230	COG0477	Major facilitator Superfamily
KY5_RS17245	COG1247	-acetyltransferase
KY5_RS17255	COG3384	dioxygenase
KY5_RS17260	COG1846	Transcriptional regulator
KY5_RS17280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KY5_RS17285	COG1120	ATPase activity
KY5_RS17290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY5_RS17300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS17310	COG0477	Major facilitator Superfamily
KY5_RS17315	COG2382	esterase
KY5_RS17320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS17330	COG1169	isochorismate synthase
KY5_RS17335	COG1021	2,3-dihydroxybenzoate-AMP ligase
KY5_RS17340	COG1535	isochorismatase
KY5_RS17340	COG3433	isochorismatase activity
KY5_RS17345	COG3433	isochorismatase activity
KY5_RS17345	COG1535	isochorismatase
KY5_RS17395	COG1132	(ABC) transporter
KY5_RS17420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY5_RS17435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS17440	COG3629	intracellular signal transduction
KY5_RS17440	COG3903	Transcriptional regulator
KY5_RS17455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS17510	COG1278	Cold shock
KY5_RS17515	COG0789	Transcriptional regulator
KY5_RS17555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KY5_RS17555	COG2124	cytochrome p450
KY5_RS17565	COG4221	oxidoreductase activity
KY5_RS17570	COG1309	transcriptional regulator
KY5_RS17580	COG5640	endopeptidase activity
KY5_RS17585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KY5_RS17625	COG1686	Belongs to the peptidase S11 family
KY5_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS17685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KY5_RS17750	COG3903	Transcriptional regulator
KY5_RS17750	COG3629	intracellular signal transduction
KY5_RS17800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KY5_RS17800	COG0515	serine threonine protein kinase
KY5_RS17805	COG1309	transcriptional regulator
KY5_RS17815	COG1960	acyl-CoA dehydrogenase activity
KY5_RS17845	COG2072	flavoprotein involved in K transport
KY5_RS17855	COG1024	Enoyl-CoA hydratase
KY5_RS17890	COG1960	acyl-CoA dehydrogenase activity
KY5_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS17915	COG1960	acyl-CoA dehydrogenase activity
KY5_RS17920	COG1960	acyl-CoA dehydrogenase activity
KY5_RS17925	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS17940	COG1366	Belongs to the anti-sigma-factor antagonist family
KY5_RS18000	COG1136	(ABC) transporter
KY5_RS18000	COG0577	efflux transmembrane transporter activity
KY5_RS18005	COG1136	(ABC) transporter
KY5_RS18005	COG0577	efflux transmembrane transporter activity
KY5_RS18020	COG0745	RESPONSE REGULATOR receiver
KY5_RS18025	COG2205	protein histidine kinase activity
KY5_RS18030	COG4821	SIS domain
KY5_RS18040	COG2945	thiolester hydrolase activity
KY5_RS18040	COG0596	Alpha beta hydrolase
KY5_RS18045	COG0259	pyridoxamine-phosphate oxidase activity
KY5_RS18090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY5_RS18110	COG0583	DNA-binding transcription factor activity
KY5_RS18125	COG0277	FAD linked oxidase domain protein
KY5_RS18150	COG2124	cytochrome p450
KY5_RS18160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KY5_RS18200	COG2272	Belongs to the type-B carboxylesterase lipase family
KY5_RS18235	COG0667	Aldo Keto reductase
KY5_RS18265	COG2252	PERMEase
KY5_RS18275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KY5_RS18300	COG2814	Major facilitator Superfamily
KY5_RS18310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KY5_RS18315	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KY5_RS18320	COG1278	Cold shock
KY5_RS18335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS18340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS18345	COG1120	ATPase activity
KY5_RS18350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY5_RS18375	COG1061	Type III restriction enzyme res subunit
KY5_RS18405	COG3973	AAA domain
KY5_RS18430	COG0110	maltose O-acetyltransferase activity
KY5_RS18465	COG1737	Transcriptional regulator
KY5_RS18470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KY5_RS18475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY5_RS18475	COG1263	PTS System
KY5_RS18495	COG2161	toxin-antitoxin pair type II binding
KY5_RS18500	COG4115	mRNA cleavage
KY5_RS18505	COG0515	serine threonine protein kinase
KY5_RS18505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KY5_RS18520	COG1115	amino acid carrier protein
KY5_RS18540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KY5_RS18545	COG0463	Glycosyl transferase, family 2
KY5_RS18555	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KY5_RS18585	COG0402	S-adenosylhomocysteine deaminase activity
KY5_RS18610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KY5_RS18620	COG2249	NAD(P)H dehydrogenase (quinone) activity
KY5_RS18635	COG0456	acetyltransferase
KY5_RS18650	COG0666	response to abiotic stimulus
KY5_RS18665	COG2197	response regulator
KY5_RS18690	COG4552	Acetyltransferase involved in intracellular survival and related
KY5_RS18715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS18725	COG0537	adenosine 5'-monophosphoramidase activity
KY5_RS18730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KY5_RS18735	COG2188	Transcriptional regulator
KY5_RS18815	COG3842	ATPase activity
KY5_RS18825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KY5_RS18840	COG0215	cysteine-tRNA ligase activity
KY5_RS18845	COG3467	pyridoxamine 5'-phosphate
KY5_RS18850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KY5_RS18855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KY5_RS18860	COG1329	Transcriptional regulator
KY5_RS18880	COG5002	protein histidine kinase activity
KY5_RS18915	COG0588	phosphoglycerate mutase activity
KY5_RS18935	COG0438	transferase activity, transferring glycosyl groups
KY5_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS19000	COG1733	regulation of RNA biosynthetic process
KY5_RS19015	COG1902	pentaerythritol trinitrate reductase activity
KY5_RS19030	COG0768	penicillin binding
KY5_RS19060	COG0546	phosphoglycolate phosphatase activity
KY5_RS19070	COG0546	phosphoglycolate phosphatase activity
KY5_RS19075	COG2186	Transcriptional regulator
KY5_RS19085	COG2186	Transcriptional regulator
KY5_RS19095	COG4552	Acetyltransferase involved in intracellular survival and related
KY5_RS19105	COG1490	D-aminoacyl-tRNA deacylase activity
KY5_RS19115	COG0735	belongs to the Fur family
KY5_RS19120	COG3485	protocatechuate 3,4-dioxygenase
KY5_RS19140	COG2897	thiosulfate sulfurtransferase activity
KY5_RS19160	COG0745	RESPONSE REGULATOR receiver
KY5_RS19165	COG1609	Transcriptional regulator
KY5_RS19170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY5_RS19180	COG0745	RESPONSE REGULATOR receiver
KY5_RS19190	COG0488	(ABC) transporter
KY5_RS19200	COG0737	Belongs to the 5'-nucleotidase family
KY5_RS19205	COG0456	acetyltransferase
KY5_RS19220	COG1116	anion transmembrane transporter activity
KY5_RS19230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KY5_RS19240	COG0406	alpha-ribazole phosphatase activity
KY5_RS19240	COG0494	nUDIX hydrolase
KY5_RS19245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KY5_RS19260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KY5_RS19265	COG0306	phosphate transporter
KY5_RS19275	COG1937	Protein conserved in bacteria
KY5_RS19290	COG0277	FAD linked oxidase domain protein
KY5_RS19295	COG0671	phosphoesterase, PA-phosphatase related
KY5_RS19300	COG1196	nuclear chromosome segregation
KY5_RS19300	COG0741	lytic transglycosylase activity
KY5_RS19300	COG0739	heme binding
KY5_RS19410	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS19420	COG1131	(ABC) transporter
KY5_RS19430	COG4585	Histidine kinase
KY5_RS19435	COG2197	response regulator
KY5_RS19475	COG1252	NADH dehydrogenase
KY5_RS19505	COG0579	oxidoreductase
KY5_RS19510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KY5_RS19520	COG0667	Aldo Keto reductase
KY5_RS19540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY5_RS19565	COG0477	Major facilitator Superfamily
KY5_RS19590	COG0513	Belongs to the DEAD box helicase family
KY5_RS19630	COG0785	Cytochrome C biogenesis protein
KY5_RS19635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KY5_RS19635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KY5_RS19645	COG1643	Atp-dependent helicase
KY5_RS19680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KY5_RS19690	COG3119	arylsulfatase activity
KY5_RS19720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KY5_RS19725	COG0047	phosphoribosylformylglycinamidine synthase activity
KY5_RS19730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KY5_RS19765	COG2197	response regulator
KY5_RS19775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KY5_RS19790	COG0151	Belongs to the GarS family
KY5_RS19825	COG0697	spore germination
KY5_RS19830	COG0583	DNA-binding transcription factor activity
KY5_RS19845	COG2268	Band 7 protein
KY5_RS19855	COG0488	(ABC) transporter
KY5_RS19870	COG0433	COG0433 Predicted ATPase
KY5_RS19885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KY5_RS19915	COG1191	sigma factor activity
KY5_RS19920	COG1191	sigma factor activity
KY5_RS19935	COG1846	Transcriptional regulator
KY5_RS19955	COG0477	Major facilitator Superfamily
KY5_RS20000	COG2197	response regulator
KY5_RS20025	COG0784	Response regulator, receiver
KY5_RS20030	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS20035	COG1595	DNA-templated transcription, initiation
KY5_RS20055	COG1960	acyl-CoA dehydrogenase activity
KY5_RS20065	COG1960	acyl-CoA dehydrogenase activity
KY5_RS20080	COG3104	oligopeptide transport
KY5_RS20090	COG0477	Major facilitator Superfamily
KY5_RS20120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY5_RS20155	COG0006	proline dipeptidase activity
KY5_RS20160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS20165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS20185	COG1999	signal sequence binding
KY5_RS20200	COG2837	iron assimilation
KY5_RS20210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KY5_RS20215	COG0561	phosphatase activity
KY5_RS20240	COG1131	(ABC) transporter
KY5_RS20260	COG0789	Transcriptional regulator
KY5_RS20275	COG0561	phosphatase activity
KY5_RS20290	COG4988	ABC transporter
KY5_RS20295	COG1294	oxidase, subunit
KY5_RS20300	COG1271	oxidase subunit
KY5_RS20305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY5_RS20310	COG1609	Transcriptional regulator
KY5_RS20340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KY5_RS20365	COG0662	Cupin 2, conserved barrel domain protein
KY5_RS20370	COG1950	PFAM Membrane protein of
KY5_RS20380	COG0626	cystathionine gamma-synthase activity
KY5_RS20420	COG2814	Major facilitator Superfamily
KY5_RS20450	COG0305	Participates in initiation and elongation during chromosome replication
KY5_RS20460	COG0359	binds to the 23S rRNA
KY5_RS20465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KY5_RS20470	COG0629	single-stranded DNA binding
KY5_RS20475	COG0360	Binds together with S18 to 16S ribosomal RNA
KY5_RS20500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KY5_RS20510	COG1260	myo-inositol-1-phosphate synthase
KY5_RS20525	COG0617	tRNA 3'-terminal CCA addition
KY5_RS20545	COG1595	DNA-templated transcription, initiation
KY5_RS20555	COG0492	ferredoxin-NADP+ reductase activity
KY5_RS20560	COG3118	belongs to the thioredoxin family
KY5_RS20575	COG1192	Involved in chromosome partitioning
KY5_RS20580	COG0357	Ribosomal RNA small subunit methyltransferase G
KY5_RS20590	COG0706	membrane insertase activity
KY5_RS20595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KY5_RS20600	COG0594	ribonuclease P activity
KY5_RS20605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KY5_RS20610	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KY5_RS20620	COG0592	DNA-directed DNA polymerase activity
KY5_RS20625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KY5_RS20630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KY5_RS20635	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KY5_RS20645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KY5_RS20680	COG0515	serine threonine protein kinase
KY5_RS20735	COG2124	cytochrome p450
KY5_RS20740	COG0477	Major facilitator Superfamily
KY5_RS20755	COG0705	Rhomboid family
KY5_RS20770	COG3764	Sortase (surface protein transpeptidase)
KY5_RS20785	COG3764	Sortase (surface protein transpeptidase)
KY5_RS20790	COG3764	Sortase (surface protein transpeptidase)
KY5_RS20795	COG0515	serine threonine protein kinase
KY5_RS20820	COG1716	ATPase activity
KY5_RS20825	COG1716	ATPase activity
KY5_RS20855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY5_RS20860	COG2151	metal-sulfur cluster biosynthetic enzyme
KY5_RS20865	COG3396	Phenylacetate-CoA oxygenase
KY5_RS20870	COG3460	Phenylacetate-CoA oxygenase
KY5_RS20875	COG3396	Phenylacetate-CoA oxygenase
KY5_RS20900	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY5_RS20905	COG1309	transcriptional regulator
KY5_RS20910	COG1522	sequence-specific DNA binding
KY5_RS20930	COG0746	molybdenum cofactor guanylyltransferase activity
KY5_RS20940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KY5_RS20945	COG3321	synthase
KY5_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS20945	COG0604	alcohol dehydrogenase
KY5_RS20965	COG0515	serine threonine protein kinase
KY5_RS20970	COG0515	serine threonine protein kinase
KY5_RS20990	COG0022	dehydrogenase e1 component
KY5_RS20995	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY5_RS21010	COG2271	Major facilitator Superfamily
KY5_RS21035	COG1362	aminopeptidase activity
KY5_RS21045	COG1960	acyl-CoA dehydrogenase activity
KY5_RS21055	COG1741	Belongs to the pirin family
KY5_RS21080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KY5_RS21105	COG1309	transcriptional regulator
KY5_RS21145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KY5_RS21165	COG0583	DNA-binding transcription factor activity
KY5_RS21175	COG1289	transmembrane transporter activity
KY5_RS21210	COG0583	DNA-binding transcription factor activity
KY5_RS21245	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS21260	COG2249	NAD(P)H dehydrogenase (quinone) activity
KY5_RS21285	COG3903	Transcriptional regulator
KY5_RS21285	COG3629	intracellular signal transduction
KY5_RS21330	COG1401	restriction endodeoxyribonuclease activity
KY5_RS21345	COG1309	transcriptional regulator
KY5_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS21375	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
KY5_RS21415	COG2188	Transcriptional regulator
KY5_RS21430	COG0717	Belongs to the dCTP deaminase family
KY5_RS21495	COG2181	nitrate reductase activity
KY5_RS21495	COG0247	lactate metabolic process
KY5_RS21500	COG0443	Heat shock 70 kDa protein
KY5_RS21505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KY5_RS21510	COG0484	heat shock protein binding
KY5_RS21515	COG0789	Transcriptional regulator
KY5_RS21560	COG0542	response to heat
KY5_RS21590	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KY5_RS21605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KY5_RS21610	COG0191	fructose-bisphosphate aldolase activity
KY5_RS21635	COG3844	kynureninase activity
KY5_RS21650	COG2197	response regulator
KY5_RS21655	COG2124	cytochrome p450
KY5_RS21660	COG3559	Exporter of polyketide antibiotics
KY5_RS21665	COG1131	(ABC) transporter
KY5_RS21680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KY5_RS21685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KY5_RS21700	COG0693	protein deglycase activity
KY5_RS21730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KY5_RS21735	COG1802	Transcriptional regulator
KY5_RS21740	COG0463	Glycosyl transferase, family 2
KY5_RS21755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KY5_RS21760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KY5_RS21785	COG1595	DNA-templated transcription, initiation
KY5_RS21805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KY5_RS21825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY5_RS21855	COG4249	Peptidase C14 caspase catalytic subunit p20
KY5_RS21855	COG2319	Wd-40 repeat
KY5_RS21880	COG1231	oxidoreductase activity
KY5_RS21895	COG0513	Belongs to the DEAD box helicase family
KY5_RS21900	COG1278	Cold shock
KY5_RS21910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY5_RS21915	COG1993	acr, cog1993
KY5_RS21920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY5_RS21930	COG0671	phosphoesterase, PA-phosphatase related
KY5_RS21940	COG0148	phosphopyruvate hydratase activity
KY5_RS21945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KY5_RS21980	COG1408	metallophosphoesterase
KY5_RS21985	COG1610	YqeY-like protein
KY5_RS22005	COG0003	Pfam Anion-transporting ATPase
KY5_RS22030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY5_RS22065	COG2267	carboxylic ester hydrolase activity
KY5_RS22075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KY5_RS22080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY5_RS22085	COG0659	secondary active sulfate transmembrane transporter activity
KY5_RS22145	COG1111	helicase
KY5_RS22145	COG1205	dead DEAH box helicase
KY5_RS22150	COG1366	Belongs to the anti-sigma-factor antagonist family
KY5_RS22155	COG2172	sigma factor antagonist activity
KY5_RS22160	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KY5_RS22170	COG2890	protein-(glutamine-N5) methyltransferase activity
KY5_RS22185	COG1754	DNA topoisomerase type I activity
KY5_RS22185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KY5_RS22190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KY5_RS22195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KY5_RS22300	COG2186	Transcriptional regulator
KY5_RS22340	COG1595	DNA-templated transcription, initiation
KY5_RS22345	COG4585	Histidine kinase
KY5_RS22350	COG2197	response regulator
KY5_RS22380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS22385	COG0596	Alpha beta hydrolase
KY5_RS22395	COG2197	response regulator
KY5_RS22400	COG4585	Histidine kinase
KY5_RS22415	COG5002	protein histidine kinase activity
KY5_RS22420	COG3903	Transcriptional regulator
KY5_RS22420	COG3629	intracellular signal transduction
KY5_RS22425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY5_RS22425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY5_RS22430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KY5_RS22430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KY5_RS22440	COG1136	(ABC) transporter
KY5_RS22455	COG2205	protein histidine kinase activity
KY5_RS22460	COG0745	RESPONSE REGULATOR receiver
KY5_RS22475	COG1136	(ABC) transporter
KY5_RS22495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KY5_RS22500	COG0254	rRNA binding
KY5_RS22540	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS22545	COG2318	DinB family
KY5_RS22565	COG0789	Transcriptional regulator
KY5_RS22570	COG0393	Putative heavy-metal-binding
KY5_RS22585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KY5_RS22590	COG2027	D-alanyl-D-alanine carboxypeptidase
KY5_RS22600	COG0037	tRNA processing
KY5_RS22615	COG0302	gtp cyclohydrolase
KY5_RS22630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KY5_RS22635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KY5_RS22665	COG1174	glycine betaine transport
KY5_RS22670	COG1174	glycine betaine transport
KY5_RS22695	COG0649	NAD binding
KY5_RS22710	COG2197	response regulator
KY5_RS22750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KY5_RS22755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KY5_RS22765	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KY5_RS22790	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KY5_RS22845	COG0739	heme binding
KY5_RS22855	COG0477	Major facilitator Superfamily
KY5_RS22865	COG0346	lactoylglutathione lyase activity
KY5_RS22870	COG2205	protein histidine kinase activity
KY5_RS22875	COG0745	RESPONSE REGULATOR receiver
KY5_RS22885	COG1595	DNA-templated transcription, initiation
KY5_RS22890	COG1194	a g-specific adenine glycosylase
KY5_RS22895	COG4585	Histidine kinase
KY5_RS22915	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KY5_RS22935	COG0248	Ppx GppA phosphatase
KY5_RS22940	COG1082	Xylose isomerase domain protein TIM barrel
KY5_RS22950	COG0129	dihydroxy-acid dehydratase activity
KY5_RS22955	COG4991	sh3 domain protein
KY5_RS22975	COG0842	Transport permease protein
KY5_RS22975	COG1129	ABC transporter
KY5_RS22985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KY5_RS22990	COG1335	isochorismatase
KY5_RS23000	COG0180	Tryptophanyl-tRNA synthetase
KY5_RS23025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY5_RS23040	COG0123	including yeast histone deacetylase and acetoin utilization protein
KY5_RS23090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KY5_RS23095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KY5_RS23100	COG0181	hydroxymethylbilane synthase activity
KY5_RS23105	COG1648	precorrin-2 dehydrogenase activity
KY5_RS23105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KY5_RS23110	COG0113	porphobilinogen synthase activity
KY5_RS23115	COG3321	synthase
KY5_RS23115	COG0604	alcohol dehydrogenase
KY5_RS23150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS23155	COG0018	arginyl-trna synthetase
KY5_RS23160	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
KY5_RS23175	COG1024	Enoyl-CoA hydratase
KY5_RS23220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KY5_RS23225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS23240	COG1834	amidinotransferase
KY5_RS23260	COG1690	Belongs to the RtcB family
KY5_RS23280	COG1742	UPF0060 membrane protein
KY5_RS23305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS23320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KY5_RS23325	COG0406	alpha-ribazole phosphatase activity
KY5_RS23335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY5_RS23340	COG0785	Cytochrome C biogenesis protein
KY5_RS23345	COG1333	cytochrome c biogenesis protein
KY5_RS23350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KY5_RS23380	COG0583	DNA-binding transcription factor activity
KY5_RS23390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KY5_RS23400	COG0163	prenyltransferase activity
KY5_RS23410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KY5_RS23425	COG1301	dicarboxylic acid transport
KY5_RS23430	COG1309	transcriptional regulator
KY5_RS23445	COG0183	Belongs to the thiolase family
KY5_RS23470	COG0583	DNA-binding transcription factor activity
KY5_RS23485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KY5_RS23550	COG0601	transmembrane transport
KY5_RS23555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS23560	COG0444	Belongs to the ABC transporter superfamily
KY5_RS23565	COG4608	Belongs to the ABC transporter superfamily
KY5_RS23570	COG1278	Cold shock
KY5_RS23575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KY5_RS23735	COG2318	DinB family
KY5_RS23740	COG5640	endopeptidase activity
KY5_RS23755	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
KY5_RS23860	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KY5_RS23870	COG2226	methyltransferase
KY5_RS23905	COG0791	NLP P60 protein
KY5_RS23905	COG3103	Sh3 type 3 domain protein
KY5_RS23905	COG1388	LysM domain
KY5_RS23915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS23920	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS23925	COG0649	NAD binding
KY5_RS23935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KY5_RS23940	COG1034	ATP synthesis coupled electron transport
KY5_RS23945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KY5_RS23950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS23955	COG0839	Belongs to the complex I subunit 6 family
KY5_RS23960	COG0713	ATP synthesis coupled electron transport
KY5_RS23965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KY5_RS23975	COG1007	ATP synthesis coupled electron transport
KY5_RS23980	COG0514	ATP-dependent DNA helicase (RecQ)
KY5_RS24000	COG0561	phosphatase activity
KY5_RS24005	COG2936	dipeptidyl-peptidase activity
KY5_RS24010	COG3104	oligopeptide transport
KY5_RS24015	COG0142	geranyltranstransferase activity
KY5_RS24055	COG1733	regulation of RNA biosynthetic process
KY5_RS24070	COG0702	epimerase
KY5_RS24080	COG0702	epimerase
KY5_RS24085	COG1733	regulation of RNA biosynthetic process
KY5_RS24090	COG1013	pyruvate-flavodoxin oxidoreductase activity
KY5_RS24095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KY5_RS24095	COG0674	pyruvate-flavodoxin oxidoreductase activity
KY5_RS24120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS24125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS24130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS24135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KY5_RS24140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KY5_RS24145	COG0839	Belongs to the complex I subunit 6 family
KY5_RS24150	COG0713	ATP synthesis coupled electron transport
KY5_RS24155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KY5_RS24165	COG1007	ATP synthesis coupled electron transport
KY5_RS24170	COG0501	Belongs to the peptidase M48B family
KY5_RS24175	COG3304	Inner membrane component domain
KY5_RS24200	COG1666	GTP binding
KY5_RS24215	COG0702	epimerase
KY5_RS24220	COG0402	S-adenosylhomocysteine deaminase activity
KY5_RS24235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KY5_RS24240	COG2030	dehydratase
KY5_RS24255	COG0477	Major facilitator Superfamily
KY5_RS24260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KY5_RS24275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KY5_RS24280	COG0436	Aminotransferase
KY5_RS24290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KY5_RS24295	COG0250	Participates in transcription elongation, termination and antitermination
KY5_RS24300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KY5_RS24305	COG0081	regulation of translation
KY5_RS24320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KY5_RS24325	COG0222	ribosome binding
KY5_RS24335	COG0085	RNA polymerase activity
KY5_RS24340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KY5_RS24355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KY5_RS24360	COG0049	tRNA binding
KY5_RS24365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KY5_RS24370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KY5_RS24375	COG0051	transcription antitermination factor activity, RNA binding
KY5_RS24380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KY5_RS24385	COG0088	Forms part of the polypeptide exit tunnel
KY5_RS24390	COG0089	rRNA binding
KY5_RS24395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KY5_RS24400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KY5_RS24405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KY5_RS24410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KY5_RS24415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KY5_RS24420	COG0255	Belongs to the universal ribosomal protein uL29 family
KY5_RS24425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KY5_RS24430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KY5_RS24435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KY5_RS24440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KY5_RS24445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KY5_RS24455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KY5_RS24460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KY5_RS24465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KY5_RS24470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KY5_RS24475	COG1841	ribosomal large subunit assembly
KY5_RS24480	COG0200	Binds to the 23S rRNA
KY5_RS24490	COG0563	adenylate kinase activity
KY5_RS24500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KY5_RS24505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KY5_RS24510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KY5_RS24515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KY5_RS24520	COG0202	RNA polymerase activity
KY5_RS24525	COG0203	ribosomal protein L17
KY5_RS24530	COG0101	tRNA pseudouridine synthase activity
KY5_RS24545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KY5_RS24550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KY5_RS24555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY5_RS24565	COG1072	(Pantothenic acid kinase))
KY5_RS24570	COG0736	holo-[acyl-carrier-protein] synthase activity
KY5_RS24585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KY5_RS24595	COG0802	atpase or kinase
KY5_RS24620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KY5_RS24650	COG4941	Belongs to the sigma-70 factor family
KY5_RS24660	COG0726	polysaccharide deacetylase
KY5_RS24675	COG0459	protein refolding
KY5_RS24680	COG4221	oxidoreductase activity
KY5_RS24690	COG0583	DNA-binding transcription factor activity
KY5_RS24705	COG1595	DNA-templated transcription, initiation
KY5_RS24715	COG0516	GMP reductase activity
KY5_RS24725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KY5_RS24740	COG0515	serine threonine protein kinase
KY5_RS24745	COG2815	serine threonine protein kinase
KY5_RS24745	COG0515	serine threonine protein kinase
KY5_RS24750	COG0515	serine threonine protein kinase
KY5_RS24750	COG2815	serine threonine protein kinase
KY5_RS24755	COG0515	serine threonine protein kinase
KY5_RS24755	COG2815	serine threonine protein kinase
KY5_RS24760	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS24790	COG0519	Catalyzes the synthesis of GMP from XMP
KY5_RS24790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KY5_RS24830	COG2197	response regulator
KY5_RS24865	COG0739	heme binding
KY5_RS24875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS24875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS24890	COG0714	Associated with various cellular activities
KY5_RS24895	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KY5_RS24900	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KY5_RS24915	COG0045	succinate-CoA ligase (ADP-forming) activity
KY5_RS24945	COG0138	bifunctional purine biosynthesis protein purh
KY5_RS24955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KY5_RS24965	COG4585	Histidine kinase
KY5_RS24970	COG2197	response regulator
KY5_RS24985	COG0039	L-malate dehydrogenase activity
KY5_RS24990	COG0477	Major facilitator Superfamily
KY5_RS25005	COG1476	TRANSCRIPTIONal
KY5_RS25020	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS25030	COG0517	IMP dehydrogenase activity
KY5_RS25030	COG4175	Glycine betaine
KY5_RS25035	COG4176	ABC-type proline glycine betaine transport system permease component
KY5_RS25045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KY5_RS25050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS25055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS25060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS25075	COG0754	glutathionylspermidine amidase activity
KY5_RS25080	COG2130	NADP-dependent
KY5_RS25095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KY5_RS25100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY5_RS25120	COG0180	Tryptophanyl-tRNA synthetase
KY5_RS25145	COG0671	phosphoesterase, PA-phosphatase related
KY5_RS25160	COG1295	ribonuclease BN
KY5_RS25165	COG1686	Belongs to the peptidase S11 family
KY5_RS25175	COG1408	metallophosphoesterase
KY5_RS25195	COG1846	Transcriptional regulator
KY5_RS25215	COG1053	succinate dehydrogenase
KY5_RS25225	COG2009	succinate dehydrogenase
KY5_RS25235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KY5_RS25265	COG1595	DNA-templated transcription, initiation
KY5_RS25295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KY5_RS25300	COG0142	geranyltranstransferase activity
KY5_RS25340	COG1595	DNA-templated transcription, initiation
KY5_RS25355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS25355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS25380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KY5_RS25390	COG1216	Glycosyl transferase, family 2
KY5_RS25405	COG2089	acid synthase
KY5_RS25490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KY5_RS25490	COG1473	amidohydrolase
KY5_RS25495	COG1744	ABC transporter substrate-binding protein PnrA-like
KY5_RS25500	COG1744	ABC transporter substrate-binding protein PnrA-like
KY5_RS25505	COG3845	ABC transporter
KY5_RS25515	COG1079	Belongs to the binding-protein-dependent transport system permease family
KY5_RS25545	COG2814	Major facilitator Superfamily
KY5_RS25550	COG0583	DNA-binding transcription factor activity
KY5_RS25560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KY5_RS25585	COG2205	protein histidine kinase activity
KY5_RS25590	COG0745	RESPONSE REGULATOR receiver
KY5_RS25595	COG1595	DNA-templated transcription, initiation
KY5_RS25630	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS25635	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS25640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KY5_RS25655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY5_RS25695	COG4770	biotin carboxylase activity
KY5_RS25705	COG0424	maF-like protein
KY5_RS25720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY5_RS25730	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KY5_RS25735	COG1024	Enoyl-CoA hydratase
KY5_RS25745	COG2986	histidine ammonia-lyase
KY5_RS25755	COG0531	amino acid
KY5_RS25805	COG1136	(ABC) transporter
KY5_RS25810	COG1404	Belongs to the peptidase S8 family
KY5_RS25820	COG1733	regulation of RNA biosynthetic process
KY5_RS25845	COG1064	alcohol dehydrogenase
KY5_RS25860	COG0740	serine-type endopeptidase activity
KY5_RS25865	COG0740	serine-type endopeptidase activity
KY5_RS25875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KY5_RS25895	COG1595	DNA-templated transcription, initiation
KY5_RS25900	COG2255	four-way junction helicase activity
KY5_RS25905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KY5_RS25920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KY5_RS25930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY5_RS25950	COG2318	DinB family
KY5_RS25965	COG1331	Highly conserved protein containing a thioredoxin domain
KY5_RS25975	COG1309	transcriptional regulator
KY5_RS25980	COG0477	Major facilitator Superfamily
KY5_RS25990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KY5_RS26005	COG0436	Aminotransferase
KY5_RS26020	COG1278	Cold shock
KY5_RS26040	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KY5_RS26055	COG1414	Transcriptional regulator
KY5_RS26060	COG0251	oxidation-reduction process
KY5_RS26065	COG2610	gluconate transmembrane transporter activity
KY5_RS26100	COG2894	cell division
KY5_RS26140	COG2885	chlorophyll binding
KY5_RS26155	COG1733	regulation of RNA biosynthetic process
KY5_RS26170	COG0667	Aldo Keto reductase
KY5_RS26175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KY5_RS26180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KY5_RS26195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS26200	COG0450	alkyl hydroperoxide reductase
KY5_RS26215	COG1136	(ABC) transporter
KY5_RS26225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KY5_RS26250	COG0114	fumarate hydratase activity
KY5_RS26260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KY5_RS26260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KY5_RS26285	COG0778	Nitroreductase
KY5_RS26290	COG1722	exodeoxyribonuclease VII activity
KY5_RS26295	COG1570	exodeoxyribonuclease VII activity
KY5_RS26305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KY5_RS26320	COG0012	GTP binding
KY5_RS26380	COG1842	Phage shock protein A
KY5_RS26395	COG2723	6-phospho-beta-galactosidase activity
KY5_RS26400	COG0395	ABC-type sugar transport system, permease component
KY5_RS26405	COG1175	transmembrane transport
KY5_RS26440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KY5_RS26445	COG1053	succinate dehydrogenase
KY5_RS26465	COG1217	gtp-binding protein TYPA
KY5_RS26475	COG0601	transmembrane transport
KY5_RS26480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS26485	COG0444	Belongs to the ABC transporter superfamily
KY5_RS26490	COG4608	Belongs to the ABC transporter superfamily
KY5_RS26500	COG1595	DNA-templated transcription, initiation
KY5_RS26510	COG4608	Belongs to the ABC transporter superfamily
KY5_RS26515	COG0444	Belongs to the ABC transporter superfamily
KY5_RS26525	COG4166	transmembrane transport
KY5_RS26530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS26540	COG0601	transmembrane transport
KY5_RS26545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS26555	COG4608	Belongs to the ABC transporter superfamily
KY5_RS26570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY5_RS26585	COG1131	(ABC) transporter
KY5_RS26595	COG4585	Histidine kinase
KY5_RS26600	COG2197	response regulator
KY5_RS26640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY5_RS26645	COG1611	Belongs to the LOG family
KY5_RS26650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KY5_RS26660	COG0519	Catalyzes the synthesis of GMP from XMP
KY5_RS26670	COG1024	Enoyl-CoA hydratase
KY5_RS26685	COG1595	DNA-templated transcription, initiation
KY5_RS26695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY5_RS26700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KY5_RS26735	COG0598	Magnesium transport protein CorA
KY5_RS26745	COG2814	Major facilitator Superfamily
KY5_RS26760	COG2095	MarC family integral membrane protein
KY5_RS26770	COG1432	Conserved Protein
KY5_RS26785	COG0513	Belongs to the DEAD box helicase family
KY5_RS26880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KY5_RS26900	COG1140	nitrate reductase beta subunit
KY5_RS26935	COG0210	DNA helicase
KY5_RS26940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY5_RS26980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KY5_RS27030	COG3480	Lon protease (S16) C-terminal proteolytic domain
KY5_RS27040	COG1615	UPF0182 protein
KY5_RS27080	COG0753	catalase activity
KY5_RS27090	COG0483	inositol monophosphate 1-phosphatase activity
KY5_RS27100	COG2076	Multidrug Resistance protein
KY5_RS27110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KY5_RS27120	COG2135	peptidase activity
KY5_RS27130	COG1595	DNA-templated transcription, initiation
KY5_RS27135	COG5662	AntiSigma factor
KY5_RS27140	COG2199	diguanylate cyclase activity
KY5_RS27140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KY5_RS27155	COG0242	peptide deformylase activity
KY5_RS27165	COG2124	cytochrome p450
KY5_RS27170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY5_RS27185	COG2337	Toxic component of a toxin-antitoxin (TA) module
KY5_RS27205	COG1966	Carbon starvation protein
KY5_RS27210	COG2188	Transcriptional regulator
KY5_RS27215	COG2182	Extracellular solute-binding protein
KY5_RS27220	COG1175	transmembrane transport
KY5_RS27225	COG0395	ABC-type sugar transport system, permease component
KY5_RS27230	COG1472	Belongs to the glycosyl hydrolase 3 family
KY5_RS27235	COG0363	glucosamine-6-phosphate deaminase activity
KY5_RS27240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KY5_RS27245	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS27250	COG1309	transcriptional regulator
KY5_RS27265	COG1597	lipid kinase activity
KY5_RS27280	COG2172	sigma factor antagonist activity
KY5_RS27295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KY5_RS27310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KY5_RS27315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY5_RS27320	COG0142	geranyltranstransferase activity
KY5_RS27365	COG1011	Hydrolase
KY5_RS27375	COG1595	DNA-templated transcription, initiation
KY5_RS27395	COG2197	response regulator
KY5_RS27420	COG4106	trans-aconitate 2-methyltransferase activity
KY5_RS27430	COG0765	amino acid transport
KY5_RS27445	COG0281	malic enzyme
KY5_RS27450	COG0604	alcohol dehydrogenase
KY5_RS27495	COG0567	Dehydrogenase, E1 component
KY5_RS27495	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY5_RS27500	COG2205	protein histidine kinase activity
KY5_RS27505	COG0745	RESPONSE REGULATOR receiver
KY5_RS27530	COG1131	(ABC) transporter
KY5_RS27540	COG1595	DNA-templated transcription, initiation
KY5_RS27545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KY5_RS27565	COG5002	protein histidine kinase activity
KY5_RS27615	COG0768	penicillin binding
KY5_RS27620	COG0772	Belongs to the SEDS family
KY5_RS27630	COG2205	protein histidine kinase activity
KY5_RS27665	COG3285	dna ligase
KY5_RS27665	COG1793	dna ligase
KY5_RS27670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KY5_RS27770	COG1222	aaa ATPase
KY5_RS27780	COG2197	response regulator
KY5_RS27795	COG0018	arginyl-trna synthetase
KY5_RS27800	COG0019	diaminopimelate decarboxylase activity
KY5_RS27805	COG0460	homoserine dehydrogenase
KY5_RS27810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KY5_RS27815	COG0083	homoserine kinase activity
KY5_RS27825	COG1316	TRANSCRIPTIONal
KY5_RS27830	COG0254	rRNA binding
KY5_RS27835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KY5_RS27840	COG2890	protein-(glutamine-N5) methyltransferase activity
KY5_RS27850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KY5_RS27855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY5_RS27875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KY5_RS27880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KY5_RS27885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KY5_RS27890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KY5_RS27895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KY5_RS27900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KY5_RS27905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KY5_RS27920	COG2197	response regulator
KY5_RS27925	COG4585	Histidine kinase
KY5_RS27950	COG1309	transcriptional regulator
KY5_RS27955	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY5_RS27970	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KY5_RS28030	COG0183	Belongs to the thiolase family
KY5_RS28045	COG0745	RESPONSE REGULATOR receiver
KY5_RS28135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS28135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS28145	COG2205	protein histidine kinase activity
KY5_RS28150	COG0745	RESPONSE REGULATOR receiver
KY5_RS28155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KY5_RS28160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY5_RS28200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KY5_RS28205	COG0280	phosphate acetyltransferase
KY5_RS28205	COG0857	belongs to the CobB CobQ family
KY5_RS28210	COG0205	6-phosphofructokinase activity
KY5_RS28230	COG0395	ABC-type sugar transport system, permease component
KY5_RS28245	COG4565	transcriptional regulatory protein
KY5_RS28250	COG3290	protein histidine kinase activity
KY5_RS28255	COG1301	dicarboxylic acid transport
KY5_RS28265	COG0477	Major facilitator Superfamily
KY5_RS28285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KY5_RS28300	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KY5_RS28305	COG1140	nitrate reductase beta subunit
KY5_RS28320	COG0492	ferredoxin-NADP+ reductase activity
KY5_RS28320	COG3118	belongs to the thioredoxin family
KY5_RS28330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KY5_RS28345	COG0366	Alpha amylase catalytic
KY5_RS28370	COG0058	SHG alpha-glucan phosphorylase activity
KY5_RS28390	COG1132	(ABC) transporter
KY5_RS28395	COG1132	(ABC) transporter
KY5_RS28400	COG1131	(ABC) transporter
KY5_RS28410	COG4585	Histidine kinase
KY5_RS28415	COG2197	response regulator
KY5_RS28425	COG0583	DNA-binding transcription factor activity
KY5_RS28445	COG1024	Enoyl-CoA hydratase
KY5_RS28475	COG3321	synthase
KY5_RS28475	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS28475	COG0604	alcohol dehydrogenase
KY5_RS28505	COG2186	Transcriptional regulator
KY5_RS28510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KY5_RS28515	COG1119	ATPase activity
KY5_RS28555	COG1760	l-serine dehydratase
KY5_RS28560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY5_RS28565	COG0509	glycine decarboxylation via glycine cleavage system
KY5_RS28570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KY5_RS28590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS28605	COG0444	Belongs to the ABC transporter superfamily
KY5_RS28610	COG4608	Belongs to the ABC transporter superfamily
KY5_RS28625	COG2860	membrane
KY5_RS28635	COG2378	regulation of single-species biofilm formation
KY5_RS28670	COG0482	sulfurtransferase activity
KY5_RS28695	COG4221	oxidoreductase activity
KY5_RS28705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KY5_RS28720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KY5_RS28725	COG0154	amidase activity
KY5_RS28735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KY5_RS28750	COG2409	Drug exporters of the RND superfamily
KY5_RS28755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY5_RS28770	COG2197	response regulator
KY5_RS28780	COG2133	pyrroloquinoline quinone binding
KY5_RS28785	COG0667	Aldo Keto reductase
KY5_RS28805	COG0440	acetolactate synthase activity
KY5_RS28810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KY5_RS28815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KY5_RS28820	COG0477	Major facilitator Superfamily
KY5_RS28835	COG3835	regulator
KY5_RS28840	COG0506	proline dehydrogenase activity
KY5_RS28845	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS28855	COG0789	Transcriptional regulator
KY5_RS28860	COG1902	pentaerythritol trinitrate reductase activity
KY5_RS28875	COG2130	NADP-dependent
KY5_RS28880	COG0583	DNA-binding transcription factor activity
KY5_RS28895	COG0473	3-isopropylmalate dehydrogenase activity
KY5_RS28900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KY5_RS28910	COG0832	Belongs to the urease beta subunit family
KY5_RS28910	COG0831	urea catabolic process
KY5_RS28915	COG0804	urea catabolic process
KY5_RS28920	COG2957	Belongs to the agmatine deiminase family
KY5_RS28950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KY5_RS29000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY5_RS29025	COG2018	Roadblock/LC7 domain
KY5_RS29045	COG2018	Roadblock/LC7 domain
KY5_RS29050	COG5002	protein histidine kinase activity
KY5_RS29060	COG0179	Fumarylacetoacetate (FAA) hydrolase
KY5_RS29065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KY5_RS29110	COG1414	Transcriptional regulator
KY5_RS29115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KY5_RS29120	COG0066	3-isopropylmalate dehydratase activity
KY5_RS29130	COG0776	regulation of translation
KY5_RS29140	COG1920	GTP binding
KY5_RS29150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KY5_RS29155	COG1181	Belongs to the D-alanine--D-alanine ligase family
KY5_RS29175	COG0351	phosphomethylpyrimidine kinase
KY5_RS29190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KY5_RS29195	COG1461	Dihydroxyacetone kinase
KY5_RS29205	COG0742	ribosomal rna small subunit methyltransferase
KY5_RS29210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KY5_RS29225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KY5_RS29230	COG0571	ribonuclease III activity
KY5_RS29235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KY5_RS29240	COG1733	regulation of RNA biosynthetic process
KY5_RS29250	COG2340	Cysteine-rich secretory protein family
KY5_RS29255	COG1254	Belongs to the acylphosphatase family
KY5_RS29275	COG0477	Major facilitator Superfamily
KY5_RS29285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KY5_RS29315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KY5_RS29325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KY5_RS29335	COG0442	prolyl-tRNA aminoacylation
KY5_RS29345	COG0228	four-way junction DNA binding
KY5_RS29350	COG1837	Belongs to the UPF0109 family
KY5_RS29355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KY5_RS29360	COG0336	Belongs to the RNA methyltransferase TrmD family
KY5_RS29365	COG0335	large ribosomal subunit rRNA binding
KY5_RS29385	COG0681	Belongs to the peptidase S26 family
KY5_RS29390	COG1051	belongs to the nudix hydrolase family
KY5_RS29400	COG0792	nuclease activity
KY5_RS29415	COG1191	sigma factor activity
KY5_RS29430	COG0052	Belongs to the universal ribosomal protein uS2 family
KY5_RS29435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KY5_RS29440	COG0528	UMP kinase activity
KY5_RS29445	COG0233	cytoplasmic translational termination
KY5_RS29450	COG0575	Belongs to the CDS family
KY5_RS29455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KY5_RS29470	COG3842	ATPase activity
KY5_RS29480	COG2197	response regulator
KY5_RS29485	COG4585	Histidine kinase
KY5_RS29490	COG0438	transferase activity, transferring glycosyl groups
KY5_RS29510	COG1136	(ABC) transporter
KY5_RS29515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KY5_RS29525	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS29545	COG0596	Alpha beta hydrolase
KY5_RS29555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KY5_RS29565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY5_RS29580	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS29590	COG3842	ATPase activity
KY5_RS29595	COG1176	ABC-type spermidine putrescine transport system, permease component I
KY5_RS29600	COG1177	transmembrane transport
KY5_RS29605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS29640	COG2508	Transcriptional regulator
KY5_RS29640	COG2508	Transcriptional regulator
KY5_RS29645	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS29665	COG0653	protein targeting
KY5_RS29670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KY5_RS29675	COG0750	zinc metalloprotease
KY5_RS29680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KY5_RS29695	COG0442	prolyl-tRNA aminoacylation
KY5_RS29700	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
KY5_RS29715	COG0779	Required for maturation of 30S ribosomal subunits
KY5_RS29730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KY5_RS29740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KY5_RS29745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KY5_RS29760	COG4608	Belongs to the ABC transporter superfamily
KY5_RS29770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY5_RS29775	COG0601	transmembrane transport
KY5_RS29780	COG0747	negative chemotaxis
KY5_RS29785	COG0455	bacterial-type flagellum organization
KY5_RS29795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KY5_RS29800	COG1185	polyribonucleotide nucleotidyltransferase activity
KY5_RS29805	COG0612	Peptidase, M16
KY5_RS29810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KY5_RS29835	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KY5_RS29840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY5_RS29845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KY5_RS29880	COG2208	phosphoserine phosphatase activity
KY5_RS29880	COG2770	Histidine kinase
KY5_RS29890	COG2205	protein histidine kinase activity
KY5_RS29890	COG3437	response regulator, receiver
KY5_RS29890	COG3850	Histidine kinase
KY5_RS29890	COG4999	Histidine kinase
KY5_RS29900	COG1674	ftsk spoiiie
KY5_RS29910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KY5_RS29920	COG1058	Belongs to the CinA family
KY5_RS29920	COG1546	Belongs to the CinA family
KY5_RS29925	COG1396	sequence-specific DNA binding
KY5_RS29930	COG0783	Belongs to the Dps family
KY5_RS29940	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS29945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KY5_RS29950	COG1201	RNA secondary structure unwinding
KY5_RS29975	COG2255	four-way junction helicase activity
KY5_RS29995	COG0628	permease
KY5_RS30005	COG1595	DNA-templated transcription, initiation
KY5_RS30010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KY5_RS30015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KY5_RS30050	COG0765	amino acid transport
KY5_RS30055	COG0765	amino acid transport
KY5_RS30060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY5_RS30065	COG1126	abc transporter atp-binding protein
KY5_RS30070	COG0745	RESPONSE REGULATOR receiver
KY5_RS30075	COG2205	protein histidine kinase activity
KY5_RS30085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KY5_RS30105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KY5_RS30115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KY5_RS30120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KY5_RS30130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KY5_RS30170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KY5_RS30175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KY5_RS30180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY5_RS30205	COG0488	(ABC) transporter
KY5_RS30210	COG0588	phosphoglycerate mutase activity
KY5_RS30235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KY5_RS30275	COG2186	Transcriptional regulator
KY5_RS30280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KY5_RS30295	COG0187	DNA topoisomerase II activity
KY5_RS30305	COG4585	Histidine kinase
KY5_RS30310	COG2197	response regulator
KY5_RS30320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY5_RS30325	COG4565	transcriptional regulatory protein
KY5_RS30330	COG3290	protein histidine kinase activity
KY5_RS30345	COG0372	Belongs to the citrate synthase family
KY5_RS30375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KY5_RS30380	COG0612	Peptidase, M16
KY5_RS30395	COG1802	Transcriptional regulator
KY5_RS30400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY5_RS30425	COG1435	thymidine kinase activity
KY5_RS30460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KY5_RS30470	COG0745	RESPONSE REGULATOR receiver
KY5_RS30475	COG2205	protein histidine kinase activity
KY5_RS30500	COG0756	dUTP diphosphatase activity
KY5_RS30520	COG0577	efflux transmembrane transporter activity
KY5_RS30520	COG1136	(ABC) transporter
KY5_RS30525	COG4591	ABC-type transport system involved in lipoprotein release permease component
KY5_RS30525	COG1136	(ABC) transporter
KY5_RS30555	COG0569	domain protein
KY5_RS30565	COG0017	Asparaginyl-tRNA synthetase
KY5_RS30585	COG0442	prolyl-tRNA aminoacylation
KY5_RS30600	COG3903	Transcriptional regulator
KY5_RS30600	COG3629	intracellular signal transduction
KY5_RS30625	COG4865	methylaspartate mutase activity
KY5_RS30630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KY5_RS30655	COG0531	amino acid
KY5_RS30660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KY5_RS30735	COG2205	protein histidine kinase activity
KY5_RS30740	COG0745	RESPONSE REGULATOR receiver
KY5_RS30750	COG2409	Drug exporters of the RND superfamily
KY5_RS30790	COG2197	response regulator
KY5_RS30805	COG0577	efflux transmembrane transporter activity
KY5_RS30805	COG1136	(ABC) transporter
KY5_RS30815	COG4221	oxidoreductase activity
KY5_RS30820	COG0300	oxidoreductase activity
KY5_RS30825	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS30845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS30850	COG1764	response to oxidative stress
KY5_RS30855	COG1846	Transcriptional regulator
KY5_RS30925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS30960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KY5_RS30965	COG2382	esterase
KY5_RS30975	COG1799	cell septum assembly
KY5_RS30980	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KY5_RS31060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS31095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KY5_RS31105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KY5_RS31110	COG0531	amino acid
KY5_RS31120	COG1024	Enoyl-CoA hydratase
KY5_RS31155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KY5_RS31180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KY5_RS31195	COG0154	amidase activity
KY5_RS31245	COG0583	DNA-binding transcription factor activity
KY5_RS31340	COG0395	ABC-type sugar transport system, permease component
KY5_RS31345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KY5_RS31365	COG1175	transmembrane transport
KY5_RS31370	COG0395	ABC-type sugar transport system, permease component
KY5_RS31385	COG0395	ABC-type sugar transport system, permease component
KY5_RS31400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KY5_RS31400	COG0515	serine threonine protein kinase
KY5_RS31405	COG1940	carbohydrate kinase activity
KY5_RS31410	COG4213	ABC transporter substrate-binding protein
KY5_RS31420	COG4214	carbohydrate transport
KY5_RS31425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KY5_RS31430	COG0531	amino acid
KY5_RS31445	COG2843	Capsule synthesis protein
KY5_RS31455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KY5_RS31480	COG1024	Enoyl-CoA hydratase
KY5_RS31480	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY5_RS31485	COG0183	Belongs to the thiolase family
KY5_RS31490	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KY5_RS31505	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KY5_RS31510	COG0446	pyridine nucleotide-disulphide oxidoreductase
KY5_RS31520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KY5_RS31525	COG3253	May function as heme-dependent peroxidase
KY5_RS31555	COG3220	belongs to the UPF0276 family
KY5_RS31575	COG1121	(ABC) transporter
KY5_RS31590	COG2267	carboxylic ester hydrolase activity
KY5_RS31600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KY5_RS31610	COG0251	oxidation-reduction process
KY5_RS31630	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS31720	COG2124	cytochrome p450
KY5_RS31735	COG3568	Endonuclease Exonuclease Phosphatase
KY5_RS31750	COG0604	alcohol dehydrogenase
KY5_RS31755	COG2326	polyphosphate kinase activity
KY5_RS31780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KY5_RS31785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KY5_RS31795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS31800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS31805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY5_RS31830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KY5_RS31840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS31850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS31860	COG1024	Enoyl-CoA hydratase
KY5_RS31865	COG1024	Enoyl-CoA hydratase
KY5_RS31870	COG2234	aminopeptidase activity
KY5_RS31870	COG4935	Belongs to the peptidase S8 family
KY5_RS31875	COG1869	D-ribose catabolic process
KY5_RS31880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY5_RS31885	COG1879	ABC-type sugar transport system periplasmic component
KY5_RS31890	COG1129	ABC transporter
KY5_RS31895	COG1609	Transcriptional regulator
KY5_RS31900	COG4249	Peptidase C14 caspase catalytic subunit p20
KY5_RS31900	COG2319	Wd-40 repeat
KY5_RS31910	COG2124	cytochrome p450
KY5_RS31955	COG0443	Heat shock 70 kDa protein
KY5_RS31960	COG0443	Heat shock 70 kDa protein
KY5_RS31965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KY5_RS32000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY5_RS32010	COG0667	Aldo Keto reductase
KY5_RS32095	COG4585	Histidine kinase
KY5_RS32100	COG2409	Drug exporters of the RND superfamily
KY5_RS32160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KY5_RS32180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY5_RS32185	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KY5_RS32205	COG0529	Catalyzes the synthesis of activated sulfate
KY5_RS32210	COG0175	sulfate reduction
KY5_RS32220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY5_RS32235	COG1960	acyl-CoA dehydrogenase activity
KY5_RS32265	COG0494	nUDIX hydrolase
KY5_RS32330	COG2124	cytochrome p450
KY5_RS32360	COG2755	lipolytic protein G-D-S-L family
KY5_RS32360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KY5_RS32365	COG0745	RESPONSE REGULATOR receiver
KY5_RS32370	COG2205	protein histidine kinase activity
KY5_RS32380	COG1162	GTPase activity
KY5_RS32410	COG1404	Belongs to the peptidase S8 family
KY5_RS32420	COG0028	Belongs to the TPP enzyme family
KY5_RS32445	COG1802	Transcriptional regulator
KY5_RS32455	COG3835	regulator
KY5_RS32475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KY5_RS32480	COG2252	PERMEase
KY5_RS32530	COG0076	glutamate decarboxylase activity
KY5_RS32570	COG0640	Transcriptional regulator
KY5_RS32630	COG2319	Wd-40 repeat
KY5_RS32630	COG4249	Peptidase C14 caspase catalytic subunit p20
KY5_RS32645	COG2205	protein histidine kinase activity
KY5_RS32690	COG3594	Acyltransferase
KY5_RS32700	COG1335	isochorismatase
KY5_RS32715	COG1316	TRANSCRIPTIONal
KY5_RS32725	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS32775	COG3629	intracellular signal transduction
KY5_RS32775	COG3903	Transcriptional regulator
KY5_RS32785	COG1960	acyl-CoA dehydrogenase activity
KY5_RS32795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY5_RS32835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KY5_RS32870	COG0598	Magnesium transport protein CorA
KY5_RS32950	COG4555	ABC transporter
KY5_RS32990	COG0443	Heat shock 70 kDa protein
KY5_RS33010	COG2197	response regulator
KY5_RS33015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY5_RS33030	COG0598	Magnesium transport protein CorA
KY5_RS33040	COG0583	DNA-binding transcription factor activity
KY5_RS33050	COG2197	response regulator
KY5_RS33055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY5_RS33060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KY5_RS33060	COG0515	serine threonine protein kinase
KY5_RS33075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KY5_RS33105	COG1595	DNA-templated transcription, initiation
KY5_RS33130	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS33140	COG2814	Major facilitator Superfamily
KY5_RS33155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KY5_RS33155	COG0515	serine threonine protein kinase
KY5_RS33160	COG3960	tartronate-semialdehyde synthase activity
KY5_RS33170	COG0753	catalase activity
KY5_RS33175	COG2084	Dehydrogenase
KY5_RS33180	COG3622	Belongs to the hyi family
KY5_RS33200	COG2351	hydroxyisourate hydrolase activity
KY5_RS33210	COG2233	PERMEase
KY5_RS33220	COG2233	PERMEase
KY5_RS33230	COG2233	PERMEase
KY5_RS33250	COG2197	response regulator
KY5_RS33295	COG0596	Alpha beta hydrolase
KY5_RS33320	COG0477	Major facilitator Superfamily
KY5_RS33330	COG2133	pyrroloquinoline quinone binding
KY5_RS33330	COG5183	chlorophyll binding
KY5_RS33335	COG0477	Major facilitator Superfamily
KY5_RS33410	COG2356	endonuclease I
KY5_RS33430	COG0300	oxidoreductase activity
KY5_RS33440	COG0588	phosphoglycerate mutase activity
KY5_RS33465	COG0436	Aminotransferase
KY5_RS33475	COG4989	oxidoreductase activity
KY5_RS33505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KY5_RS33510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KY5_RS33520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY5_RS33535	COG4585	Histidine kinase
KY5_RS33540	COG0577	efflux transmembrane transporter activity
KY5_RS33545	COG1136	(ABC) transporter
KY5_RS33550	COG1414	Transcriptional regulator
KY5_RS33555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY5_RS33560	COG4266	Belongs to the allantoicase family
KY5_RS33565	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS33595	COG2197	response regulator
KY5_RS33605	COG0673	inositol 2-dehydrogenase activity
KY5_RS33610	COG2188	Transcriptional regulator
KY5_RS33635	COG1940	carbohydrate kinase activity
KY5_RS33655	COG2423	ornithine cyclodeaminase activity
KY5_RS33710	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS33750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS33755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KY5_RS33770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KY5_RS33780	COG0475	glutathione-regulated potassium exporter activity
KY5_RS33790	COG0439	Biotin carboxylase
KY5_RS33795	COG0825	malonyl-CoA metabolic process
KY5_RS33795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KY5_RS33800	COG3850	Histidine kinase
KY5_RS33810	COG0511	ligase activity, forming carbon-carbon bonds
KY5_RS33815	COG2867	negative regulation of translational initiation
KY5_RS33835	COG0662	Cupin 2, conserved barrel domain protein
KY5_RS33840	COG2329	Antibiotic biosynthesis monooxygenase
KY5_RS33870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS33880	COG0477	Major facilitator Superfamily
KY5_RS33885	COG2197	response regulator
KY5_RS33890	COG4585	Histidine kinase
KY5_RS33895	COG1131	(ABC) transporter
KY5_RS33905	COG0069	glutamate synthase activity
KY5_RS33925	COG1126	abc transporter atp-binding protein
KY5_RS33930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY5_RS33935	COG0765	amino acid transport
KY5_RS33940	COG0765	amino acid transport
KY5_RS33945	COG2936	dipeptidyl-peptidase activity
KY5_RS33950	COG1376	ErfK ybiS ycfS ynhG family protein
KY5_RS33960	COG0405	Gamma-glutamyltransferase
KY5_RS33990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KY5_RS33995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY5_RS34010	COG0736	holo-[acyl-carrier-protein] synthase activity
KY5_RS34035	COG0657	acetylesterase activity
KY5_RS34060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS34070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS34100	COG2267	carboxylic ester hydrolase activity
KY5_RS34105	COG0477	Major facilitator Superfamily
KY5_RS34115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS34145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KY5_RS34165	COG2050	protein possibly involved in aromatic compounds catabolism
KY5_RS34180	COG1960	acyl-CoA dehydrogenase activity
KY5_RS34195	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS34200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KY5_RS34215	COG2267	carboxylic ester hydrolase activity
KY5_RS34220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KY5_RS34240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS34240	COG3320	Male sterility
KY5_RS34265	COG2226	methyltransferase
KY5_RS34275	COG2197	response regulator
KY5_RS34285	COG0095	Lipoate-protein ligase
KY5_RS34295	COG0483	inositol monophosphate 1-phosphatase activity
KY5_RS34310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KY5_RS34345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KY5_RS34350	COG1929	Belongs to the glycerate kinase type-1 family
KY5_RS34375	COG1063	alcohol dehydrogenase
KY5_RS34385	COG0688	phosphatidylethanolamine metabolic process
KY5_RS34390	COG1960	acyl-CoA dehydrogenase activity
KY5_RS34400	COG2301	Belongs to the HpcH HpaI aldolase family
KY5_RS34405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS34405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KY5_RS34410	COG0604	alcohol dehydrogenase
KY5_RS34420	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY5_RS34460	COG2172	sigma factor antagonist activity
KY5_RS34460	COG1366	Belongs to the anti-sigma-factor antagonist family
KY5_RS34460	COG2208	phosphoserine phosphatase activity
KY5_RS34475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KY5_RS34485	COG4214	carbohydrate transport
KY5_RS34515	COG1414	Transcriptional regulator
KY5_RS34520	COG3386	PFAM SMP-30 Gluconolaconase
KY5_RS34530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KY5_RS34535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS34560	COG2249	NAD(P)H dehydrogenase (quinone) activity
KY5_RS34570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KY5_RS34575	COG3467	pyridoxamine 5'-phosphate
KY5_RS34590	COG2362	D-Aminopeptidase
KY5_RS34595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY5_RS34605	COG1619	proteins homologs of microcin C7 resistance protein MccF
KY5_RS34635	COG0010	Belongs to the arginase family
KY5_RS34645	COG0402	S-adenosylhomocysteine deaminase activity
KY5_RS34675	COG4948	Mandelate Racemase Muconate Lactonizing
KY5_RS34695	COG3285	dna ligase
KY5_RS34695	COG1793	dna ligase
KY5_RS34760	COG1597	lipid kinase activity
KY5_RS34765	COG0488	(ABC) transporter
KY5_RS34785	COG0693	protein deglycase activity
KY5_RS34790	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KY5_RS34795	COG1191	sigma factor activity
KY5_RS34835	COG0531	amino acid
KY5_RS34850	COG0443	Heat shock 70 kDa protein
KY5_RS34865	COG1140	nitrate reductase beta subunit
KY5_RS34885	COG2154	pterin-4-alpha-carbinolamine dehydratase
KY5_RS34890	COG2226	methyltransferase
KY5_RS34940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KY5_RS34955	COG3469	chitinase activity
KY5_RS34995	COG0477	Major facilitator Superfamily
KY5_RS35005	COG0583	DNA-binding transcription factor activity
KY5_RS35030	COG1846	Transcriptional regulator
KY5_RS35035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KY5_RS35045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KY5_RS35050	COG3383	formate dehydrogenase (NAD+) activity
KY5_RS35055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KY5_RS35065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY5_RS35080	COG1940	carbohydrate kinase activity
KY5_RS35085	COG1129	ABC transporter
KY5_RS35090	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY5_RS35095	COG1879	ABC-type sugar transport system periplasmic component
KY5_RS35100	COG0673	inositol 2-dehydrogenase activity
KY5_RS35140	COG0084	hydrolase, TatD family'
KY5_RS35165	COG2223	nitrite transmembrane transporter activity
KY5_RS35175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY5_RS35185	COG0045	succinate-CoA ligase (ADP-forming) activity
KY5_RS35195	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS35220	COG1802	Transcriptional regulator
KY5_RS35225	COG3938	Belongs to the proline racemase family
KY5_RS35230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY5_RS35250	COG2207	Transcriptional regulator
KY5_RS35255	COG2223	nitrite transmembrane transporter activity
KY5_RS35265	COG1472	Belongs to the glycosyl hydrolase 3 family
KY5_RS35270	COG1063	alcohol dehydrogenase
KY5_RS35295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KY5_RS35310	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS35320	COG2423	ornithine cyclodeaminase activity
KY5_RS35340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS35345	COG3227	Zinc metalloprotease (Elastase)
KY5_RS35360	COG0583	DNA-binding transcription factor activity
KY5_RS35370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KY5_RS35375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KY5_RS35395	COG2814	Major facilitator Superfamily
KY5_RS35405	COG1404	Belongs to the peptidase S8 family
KY5_RS35415	COG3629	intracellular signal transduction
KY5_RS35445	COG0577	efflux transmembrane transporter activity
KY5_RS35445	COG1136	(ABC) transporter
KY5_RS35465	COG3246	L-lysine catabolic process to acetate
KY5_RS35470	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY5_RS35480	COG0477	Major facilitator Superfamily
KY5_RS35490	COG1486	melibiose metabolic process
KY5_RS35520	COG1309	transcriptional regulator
KY5_RS35525	COG2318	DinB family
KY5_RS35530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY5_RS35540	COG3511	phospholipase C
KY5_RS35575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KY5_RS35580	COG1960	acyl-CoA dehydrogenase activity
KY5_RS35585	COG1960	acyl-CoA dehydrogenase activity
KY5_RS35595	COG1309	transcriptional regulator
KY5_RS35600	COG0183	Belongs to the thiolase family
KY5_RS35605	COG1672	PFAM Archaeal ATPase
KY5_RS35605	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KY5_RS35625	COG1024	Enoyl-CoA hydratase
KY5_RS35635	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS35650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS35655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KY5_RS35660	COG3485	protocatechuate 3,4-dioxygenase
KY5_RS35665	COG3485	protocatechuate 3,4-dioxygenase
KY5_RS35680	COG1846	Transcriptional regulator
KY5_RS35695	COG1793	dna ligase
KY5_RS35700	COG3285	dna ligase
KY5_RS35700	COG1793	dna ligase
KY5_RS35735	COG2814	Major facilitator Superfamily
KY5_RS35765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY5_RS35770	COG1116	anion transmembrane transporter activity
KY5_RS35775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KY5_RS35780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS35810	COG1522	sequence-specific DNA binding
KY5_RS35820	COG1687	branched-chain amino acid
KY5_RS35835	COG1834	amidinotransferase
KY5_RS35840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KY5_RS35845	COG0488	(ABC) transporter
KY5_RS35895	COG2268	Band 7 protein
KY5_RS35905	COG1515	deoxyribonuclease V activity
KY5_RS35910	COG3268	Saccharopine dehydrogenase
KY5_RS35915	COG1683	Conserved Protein
KY5_RS35920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KY5_RS35925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS35930	COG1960	acyl-CoA dehydrogenase activity
KY5_RS35935	COG0183	Belongs to the thiolase family
KY5_RS35940	COG1024	Enoyl-CoA hydratase
KY5_RS35940	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY5_RS35950	COG0789	Transcriptional regulator
KY5_RS35960	COG1113	amino acid transport
KY5_RS35965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KY5_RS35990	COG2936	dipeptidyl-peptidase activity
KY5_RS36000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KY5_RS36010	COG0488	(ABC) transporter
KY5_RS36015	COG2183	response to ionizing radiation
KY5_RS36025	COG4977	sequence-specific DNA binding
KY5_RS36035	COG1024	Enoyl-CoA hydratase
KY5_RS36050	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KY5_RS36105	COG1134	teichoic acid transport
KY5_RS36110	COG1562	ergosterol biosynthetic process
KY5_RS36120	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KY5_RS36130	COG1657	PFAM Prenyltransferase squalene oxidase
KY5_RS36145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KY5_RS36150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KY5_RS36170	COG2365	Tyrosine phosphatase family
KY5_RS36180	COG2755	lipolytic protein G-D-S-L family
KY5_RS36185	COG0477	Major facilitator Superfamily
KY5_RS36235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY5_RS36275	COG1609	Transcriptional regulator
KY5_RS36290	COG0673	inositol 2-dehydrogenase activity
KY5_RS36295	COG1063	alcohol dehydrogenase
KY5_RS36300	COG0156	8-amino-7-oxononanoate synthase activity
KY5_RS36305	COG0583	DNA-binding transcription factor activity
KY5_RS36315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY5_RS36325	COG1116	anion transmembrane transporter activity
KY5_RS36350	COG2267	carboxylic ester hydrolase activity
KY5_RS36365	COG3958	Transketolase
KY5_RS36370	COG3959	Transketolase, thiamine diphosphate binding domain
KY5_RS36430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS36435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS36455	COG1652	LysM domain
KY5_RS36495	COG2326	polyphosphate kinase activity
KY5_RS36500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KY5_RS36535	COG0298	carbon dioxide binding
KY5_RS36540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY5_RS36540	COG1042	CoA-binding domain protein
KY5_RS36540	COG0045	succinate-CoA ligase (ADP-forming) activity
KY5_RS36585	COG0516	GMP reductase activity
KY5_RS36585	COG0517	IMP dehydrogenase activity
KY5_RS36610	COG2205	protein histidine kinase activity
KY5_RS36615	COG0745	RESPONSE REGULATOR receiver
KY5_RS36620	COG1017	nitric oxide dioxygenase activity
KY5_RS36620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY5_RS36675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KY5_RS36700	COG2175	clavaminate synthase activity
KY5_RS36770	COG1309	transcriptional regulator
KY5_RS36780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY5_RS36800	COG1755	Isoprenylcysteine carboxyl methyltransferase
KY5_RS36815	COG2409	Drug exporters of the RND superfamily
KY5_RS36820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY5_RS36825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS36860	COG0321	lipoyl(octanoyl) transferase activity
KY5_RS36870	COG0668	transmembrane transport
KY5_RS36875	COG1132	(ABC) transporter
KY5_RS36905	COG1175	transmembrane transport
KY5_RS36925	COG2197	response regulator
KY5_RS36935	COG4585	Histidine kinase
KY5_RS36960	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS36995	COG0183	Belongs to the thiolase family
KY5_RS37000	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS37005	COG0583	DNA-binding transcription factor activity
KY5_RS37040	COG0596	Alpha beta hydrolase
KY5_RS37040	COG2945	thiolester hydrolase activity
KY5_RS37075	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS37100	COG2186	Transcriptional regulator
KY5_RS37105	COG2807	transmembrane transport
KY5_RS37115	COG1132	(ABC) transporter
KY5_RS37140	COG0583	DNA-binding transcription factor activity
KY5_RS37155	COG3321	synthase
KY5_RS37155	COG0604	alcohol dehydrogenase
KY5_RS37165	COG0604	alcohol dehydrogenase
KY5_RS37165	COG3321	synthase
KY5_RS37205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS37210	COG0179	Fumarylacetoacetate (FAA) hydrolase
KY5_RS37240	COG0583	DNA-binding transcription factor activity
KY5_RS37260	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS37270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KY5_RS37290	COG3458	cephalosporin-C deacetylase activity
KY5_RS37310	COG0297	glycogen (starch) synthase activity
KY5_RS37315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KY5_RS37320	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY5_RS37325	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY5_RS37330	COG1129	ABC transporter
KY5_RS37335	COG1879	ABC-type sugar transport system periplasmic component
KY5_RS37340	COG1609	Transcriptional regulator
KY5_RS37345	COG3250	beta-galactosidase activity
KY5_RS37350	COG3537	Alpha-1,2-mannosidase
KY5_RS37380	COG1609	Transcriptional regulator
KY5_RS37385	COG1653	transport
KY5_RS37390	COG1175	transmembrane transport
KY5_RS37395	COG0395	ABC-type sugar transport system, permease component
KY5_RS37410	COG2186	Transcriptional regulator
KY5_RS37420	COG1129	ABC transporter
KY5_RS37430	COG4948	Mandelate Racemase Muconate Lactonizing
KY5_RS37435	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS37445	COG3254	rhamnose metabolic process
KY5_RS37465	COG2197	response regulator
KY5_RS37470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KY5_RS37485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KY5_RS37515	COG4209	transmembrane transport
KY5_RS37520	COG0395	ABC-type sugar transport system, permease component
KY5_RS37530	COG0531	amino acid
KY5_RS37540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KY5_RS37540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KY5_RS37565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KY5_RS37615	COG0583	DNA-binding transcription factor activity
KY5_RS37625	COG1053	succinate dehydrogenase
KY5_RS37630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KY5_RS37640	COG3708	Transcriptional regulator
KY5_RS37640	COG2207	Transcriptional regulator
KY5_RS37670	COG3424	synthase
KY5_RS37675	COG1024	Enoyl-CoA hydratase
KY5_RS37680	COG1024	Enoyl-CoA hydratase
KY5_RS37685	COG2267	carboxylic ester hydrolase activity
KY5_RS37695	COG1132	(ABC) transporter
KY5_RS37700	COG0745	RESPONSE REGULATOR receiver
KY5_RS37705	COG2205	protein histidine kinase activity
KY5_RS37710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS37730	COG2124	cytochrome p450
KY5_RS37735	COG2124	cytochrome p450
KY5_RS37750	COG0475	glutathione-regulated potassium exporter activity
KY5_RS37765	COG0577	efflux transmembrane transporter activity
KY5_RS37765	COG1136	(ABC) transporter
KY5_RS37770	COG0577	efflux transmembrane transporter activity
KY5_RS37775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS37790	COG2182	Extracellular solute-binding protein
KY5_RS37795	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KY5_RS37800	COG0121	glutamine amidotransferase
KY5_RS37805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KY5_RS37835	COG1609	Transcriptional regulator
KY5_RS37840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY5_RS37845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY5_RS37850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY5_RS37855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY5_RS37870	COG0438	transferase activity, transferring glycosyl groups
KY5_RS37880	COG2205	protein histidine kinase activity
KY5_RS37880	COG2972	Histidine kinase
KY5_RS37900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS37905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY5_RS37935	COG0702	epimerase
KY5_RS37940	COG1733	regulation of RNA biosynthetic process
KY5_RS37985	COG4106	trans-aconitate 2-methyltransferase activity
KY5_RS38005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KY5_RS38035	COG1309	transcriptional regulator
KY5_RS38055	COG1846	Transcriptional regulator
KY5_RS38075	COG0640	Transcriptional regulator
KY5_RS38085	COG0655	NAD(P)H dehydrogenase (quinone) activity
KY5_RS38120	COG2890	protein-(glutamine-N5) methyltransferase activity
KY5_RS38130	COG3383	formate dehydrogenase (NAD+) activity
KY5_RS38130	COG0243	molybdopterin cofactor binding
KY5_RS38135	COG0437	4 iron, 4 sulfur cluster binding
KY5_RS38145	COG0651	ATP synthesis coupled electron transport
KY5_RS38175	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KY5_RS38200	COG0517	IMP dehydrogenase activity
KY5_RS38200	COG0516	GMP reductase activity
KY5_RS38215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY5_RS38250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KY5_RS38260	COG0028	Belongs to the TPP enzyme family
KY5_RS38265	COG0277	FAD linked oxidase domain protein
KY5_RS38265	COG0247	lactate metabolic process
KY5_RS38280	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS38295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KY5_RS38325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS38370	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KY5_RS38395	COG4638	Rieske (2fe-2S)
KY5_RS38410	COG2226	methyltransferase
KY5_RS38415	COG3153	acetyltransferase
KY5_RS38415	COG0456	acetyltransferase
KY5_RS38460	COG0515	serine threonine protein kinase
KY5_RS38460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KY5_RS38470	COG3903	Transcriptional regulator
KY5_RS38470	COG3629	intracellular signal transduction
KY5_RS38500	COG3594	Acyltransferase
KY5_RS38520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KY5_RS38540	COG1024	Enoyl-CoA hydratase
KY5_RS38550	COG1122	ATPase activity
KY5_RS38555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KY5_RS38560	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
KY5_RS38565	COG0310	cobalt ion transport
KY5_RS38595	COG1316	TRANSCRIPTIONal
KY5_RS38610	COG2192	nodulation
KY5_RS38635	COG1271	oxidase subunit
KY5_RS38645	COG4988	ABC transporter
KY5_RS38650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KY5_RS38655	COG3629	intracellular signal transduction
KY5_RS38655	COG3903	Transcriptional regulator
KY5_RS38680	COG1280	lysine exporter protein (LysE YggA)
KY5_RS38690	COG2124	cytochrome p450
KY5_RS38715	COG0640	Transcriptional regulator
KY5_RS38740	COG2318	DinB family
KY5_RS38745	COG1960	acyl-CoA dehydrogenase activity
KY5_RS38750	COG0596	Alpha beta hydrolase
KY5_RS38760	COG0515	serine threonine protein kinase
KY5_RS38765	COG1309	transcriptional regulator
KY5_RS38800	COG2070	2-Nitropropane dioxygenase
KY5_RS38810	COG2366	antibiotic biosynthetic process
KY5_RS38820	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS38845	COG1605	Chorismate mutase
KY5_RS38900	COG2318	DinB family
KY5_RS38910	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS38955	COG2197	response regulator
KY5_RS38960	COG4585	Histidine kinase
KY5_RS38970	COG1131	(ABC) transporter
KY5_RS38980	COG1733	regulation of RNA biosynthetic process
KY5_RS38990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY5_RS38995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KY5_RS39000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KY5_RS39030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY5_RS39035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KY5_RS39040	COG0475	glutathione-regulated potassium exporter activity
KY5_RS39070	COG2070	2-Nitropropane dioxygenase
KY5_RS39070	COG2070	2-Nitropropane dioxygenase
KY5_RS39080	COG4221	oxidoreductase activity
KY5_RS39085	COG0154	amidase activity
KY5_RS39090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KY5_RS39140	COG1733	regulation of RNA biosynthetic process
KY5_RS39165	COG4948	Mandelate Racemase Muconate Lactonizing
KY5_RS39205	COG4249	Peptidase C14 caspase catalytic subunit p20
KY5_RS39205	COG2319	Wd-40 repeat
KY5_RS39225	COG2814	Major facilitator Superfamily
KY5_RS39240	COG0076	glutamate decarboxylase activity
KY5_RS39265	COG0542	response to heat
KY5_RS39275	COG0181	hydroxymethylbilane synthase activity
KY5_RS39330	COG1021	2,3-dihydroxybenzoate-AMP ligase
KY5_RS39355	COG0673	inositol 2-dehydrogenase activity
KY5_RS39360	COG1686	Belongs to the peptidase S11 family
KY5_RS39365	COG0386	Belongs to the glutathione peroxidase family
KY5_RS39430	COG2706	6-phosphogluconolactonase activity
KY5_RS39455	COG0789	Transcriptional regulator
KY5_RS39460	COG1819	glycosyl
KY5_RS39475	COG0435	Glutathione S-transferase
KY5_RS39490	COG1309	transcriptional regulator
KY5_RS39495	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KY5_RS39505	COG0738	Major facilitator superfamily
KY5_RS39515	COG1940	carbohydrate kinase activity
KY5_RS39515	COG1846	Transcriptional regulator
KY5_RS39530	COG1132	(ABC) transporter
KY5_RS39545	COG2197	response regulator
KY5_RS39560	COG2124	cytochrome p450
KY5_RS39610	COG0604	alcohol dehydrogenase
KY5_RS39610	COG3321	synthase
KY5_RS39630	COG0477	Major facilitator Superfamily
KY5_RS39690	COG3291	Pkd domain containing protein
KY5_RS39695	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KY5_RS39695	COG3408	Glycogen debranching enzyme
KY5_RS39705	COG0395	ABC-type sugar transport system, permease component
KY5_RS39715	COG1653	transport
KY5_RS39720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY5_RS39725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY5_RS39735	COG1028	Short-chain dehydrogenase reductase Sdr
KY5_RS39740	COG1802	Transcriptional regulator
KY5_RS39745	COG3590	peptidase
KY5_RS39750	COG1595	DNA-templated transcription, initiation
KY5_RS39785	COG0494	nUDIX hydrolase
KY5_RS39795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KY5_RS39825	COG1012	belongs to the aldehyde dehydrogenase family
KY5_RS39860	COG1609	Transcriptional regulator
KY5_RS39865	COG1957	nucleoside hydrolase
KY5_RS39870	COG0477	Major facilitator Superfamily
KY5_RS39885	COG1522	sequence-specific DNA binding
KY5_RS39895	COG0583	DNA-binding transcription factor activity
KY5_RS39905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KY5_RS39920	COG0596	Alpha beta hydrolase
KY5_RS39940	COG0789	Transcriptional regulator
KY5_RS39945	COG2367	Beta-lactamase
KY5_RS39955	COG0137	argininosuccinate synthase activity
KY5_RS39965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KY5_RS39985	COG2010	Cytochrome c
KY5_RS39985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KY5_RS39995	COG1295	ribonuclease BN
KY5_RS40010	COG0583	DNA-binding transcription factor activity
KY5_RS40025	COG0248	Ppx GppA phosphatase
KY5_RS40040	COG1175	transmembrane transport
KY5_RS40050	COG0366	Alpha amylase catalytic
KY5_RS40110	COG0006	proline dipeptidase activity
KY5_RS40150	COG3395	kinase activity
KY5_RS40160	COG3622	Belongs to the hyi family
KY5_RS40175	COG0513	Belongs to the DEAD box helicase family
KY5_RS40185	COG3896	Chloramphenicol phosphotransferase-like protein
KY5_RS40210	COG1132	(ABC) transporter
KY5_RS40235	COG0659	secondary active sulfate transmembrane transporter activity
KY5_RS40240	COG1132	(ABC) transporter
KY5_RS40245	COG1132	(ABC) transporter
KY5_RS40250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KY5_RS40280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KY5_RS40315	COG1819	glycosyl
KY5_RS40325	COG2226	methyltransferase
KY5_RS40375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY5_RS40380	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KY5_RS40395	COG1819	glycosyl
KY5_RS40400	COG2318	DinB family
KY5_RS40440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KY5_RS40460	COG1136	(ABC) transporter
KY5_RS40465	COG0577	efflux transmembrane transporter activity
KY5_RS40470	COG0745	RESPONSE REGULATOR receiver
KY5_RS40475	COG2205	protein histidine kinase activity
KY5_RS40495	COG0515	serine threonine protein kinase
KY5_RS40495	COG2815	serine threonine protein kinase
KY5_RS40510	COG2045	Belongs to the ComB family
KY5_RS40525	COG0667	Aldo Keto reductase
KY5_RS40535	COG2175	clavaminate synthase activity
KY5_RS40540	COG0010	Belongs to the arginase family
KY5_RS40545	COG0367	asparagine synthase
KY5_RS40570	COG1349	DNA-binding transcription factor activity
KY5_RS40605	COG0328	RNA-DNA hybrid ribonuclease activity
KY5_RS40615	COG2197	response regulator
KY5_RS40645	COG3655	Transcriptional regulator
KY5_RS40670	COG0667	Aldo Keto reductase
KY5_RS40675	COG1522	sequence-specific DNA binding
KY5_RS40680	COG4257	antibiotic catabolic process
KY5_RS40705	COG0702	epimerase
KY5_RS40710	COG3631	Ketosteroid isomerase-related protein
KY5_RS40735	COG2267	carboxylic ester hydrolase activity
KY5_RS40765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY5_RS40795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KY5_RS40800	COG2197	response regulator
KY5_RS40800	COG3903	Transcriptional regulator
KY5_RS40805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KY5_RS40815	COG2124	cytochrome p450
KY5_RS40865	COG0730	response to heat
KY5_RS40870	COG1937	Protein conserved in bacteria
KY5_RS40875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY5_RS40890	COG1695	Transcriptional regulator
KY5_RS40905	COG0778	Nitroreductase
KY5_RS40910	COG1309	transcriptional regulator
KY5_RS40930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY5_RS40935	COG1090	epimerase
KY5_RS40940	COG1017	nitric oxide dioxygenase activity
KY5_RS40940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY5_RS41015	COG2205	protein histidine kinase activity
KY5_RS41020	COG0745	RESPONSE REGULATOR receiver
KY5_RS41070	COG1397	ADP-ribosylglycohydrolase
KY5_RS41100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KY5_RS41140	COG0477	Major facilitator Superfamily
KY5_RS41160	COG0318	PFAM AMP-dependent synthetase and ligase
KY5_RS41165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY5_RS41170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KY5_RS41190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KY5_RS41205	COG1032	radical SAM domain protein
KY5_RS41225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY5_RS41245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY5_RS41265	COG0488	(ABC) transporter
KY5_RS41270	COG0488	(ABC) transporter