locus-tag	class	description
CP974_RS00010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS00065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS00195	COG0655	NAD(P)H dehydrogenase (quinone) activity
CP974_RS00205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS00215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP974_RS00240	COG2267	carboxylic ester hydrolase activity
CP974_RS00295	COG1937	Protein conserved in bacteria
CP974_RS00300	COG4989	oxidoreductase activity
CP974_RS00305	COG1742	UPF0060 membrane protein
CP974_RS00360	COG1191	sigma factor activity
CP974_RS00375	COG1278	Cold shock
CP974_RS00420	COG2205	protein histidine kinase activity
CP974_RS00420	COG0784	Response regulator, receiver
CP974_RS00420	COG5002	protein histidine kinase activity
CP974_RS00435	COG2271	Major facilitator Superfamily
CP974_RS00470	COG3655	Transcriptional regulator
CP974_RS00480	COG3548	integral membrane protein
CP974_RS00485	COG0640	Transcriptional regulator
CP974_RS00490	COG1902	pentaerythritol trinitrate reductase activity
CP974_RS00500	COG2223	nitrite transmembrane transporter activity
CP974_RS00505	COG2207	Transcriptional regulator
CP974_RS00530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP974_RS00530	COG2308	Evidence 4 Homologs of previously reported genes of
CP974_RS00540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CP974_RS00545	COG2326	polyphosphate kinase activity
CP974_RS00565	COG2226	methyltransferase
CP974_RS00655	COG0463	Glycosyl transferase, family 2
CP974_RS00710	COG2366	antibiotic biosynthetic process
CP974_RS00715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP974_RS00730	COG0515	serine threonine protein kinase
CP974_RS00730	COG2815	serine threonine protein kinase
CP974_RS00740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP974_RS00740	COG0723	plastoquinol--plastocyanin reductase activity
CP974_RS00770	COG4209	transmembrane transport
CP974_RS00775	COG0395	ABC-type sugar transport system, permease component
CP974_RS00815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CP974_RS00815	COG1796	DNA polymerase
CP974_RS00835	COG1295	ribonuclease BN
CP974_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS00845	COG1716	ATPase activity
CP974_RS00845	COG0842	Transport permease protein
CP974_RS00845	COG1131	(ABC) transporter
CP974_RS00870	COG0778	Nitroreductase
CP974_RS00890	COG1404	Belongs to the peptidase S8 family
CP974_RS00910	COG3766	membrane
CP974_RS00920	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP974_RS00935	COG0006	proline dipeptidase activity
CP974_RS00940	COG0006	proline dipeptidase activity
CP974_RS00950	COG3291	Pkd domain containing protein
CP974_RS00955	COG3938	Belongs to the proline racemase family
CP974_RS00960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP974_RS00965	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP974_RS00970	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP974_RS00970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP974_RS00975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP974_RS00985	COG2376	Dihydroxyacetone kinase
CP974_RS00990	COG1461	Dihydroxyacetone kinase
CP974_RS01000	COG0310	cobalt ion transport
CP974_RS01005	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CP974_RS01015	COG1122	ATPase activity
CP974_RS01020	COG0477	Major facilitator Superfamily
CP974_RS01035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP974_RS01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP974_RS01040	COG1902	pentaerythritol trinitrate reductase activity
CP974_RS01115	COG0753	catalase activity
CP974_RS01140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CP974_RS01160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP974_RS01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP974_RS01180	COG0438	transferase activity, transferring glycosyl groups
CP974_RS01185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CP974_RS01190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CP974_RS01190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CP974_RS01200	COG4221	oxidoreductase activity
CP974_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS01285	COG4106	trans-aconitate 2-methyltransferase activity
CP974_RS01290	COG3290	protein histidine kinase activity
CP974_RS01300	COG0596	Alpha beta hydrolase
CP974_RS01335	COG2239	Acts as a magnesium transporter
CP974_RS01350	COG0574	Belongs to the PEP-utilizing enzyme family
CP974_RS01350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP974_RS01360	COG0730	response to heat
CP974_RS01370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP974_RS01370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP974_RS01375	COG2124	cytochrome p450
CP974_RS01380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP974_RS01425	COG2124	cytochrome p450
CP974_RS01450	COG1796	DNA polymerase
CP974_RS01450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CP974_RS01455	COG3962	Belongs to the TPP enzyme family
CP974_RS01460	COG3718	enzyme involved in inositol metabolism
CP974_RS01570	COG0640	Transcriptional regulator
CP974_RS01595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP974_RS01615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP974_RS01615	COG1017	nitric oxide dioxygenase activity
CP974_RS01620	COG1959	2 iron, 2 sulfur cluster binding
CP974_RS01630	COG4106	trans-aconitate 2-methyltransferase activity
CP974_RS01665	COG0328	RNA-DNA hybrid ribonuclease activity
CP974_RS01675	COG1733	regulation of RNA biosynthetic process
CP974_RS01710	COG1309	transcriptional regulator
CP974_RS01720	COG0789	Transcriptional regulator
CP974_RS01745	COG2723	6-phospho-beta-galactosidase activity
CP974_RS01755	COG1482	cell wall glycoprotein biosynthetic process
CP974_RS01765	COG1609	Transcriptional regulator
CP974_RS01770	COG3250	beta-galactosidase activity
CP974_RS01780	COG1175	transmembrane transport
CP974_RS01785	COG0395	ABC-type sugar transport system, permease component
CP974_RS01790	COG1051	belongs to the nudix hydrolase family
CP974_RS01800	COG2226	methyltransferase
CP974_RS01835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP974_RS01865	COG1215	transferase activity, transferring glycosyl groups
CP974_RS01885	COG0464	growth
CP974_RS01895	COG1349	DNA-binding transcription factor activity
CP974_RS01945	COG1940	carbohydrate kinase activity
CP974_RS01980	COG0445	tRNA wobble uridine modification
CP974_RS02000	COG1660	Displays ATPase and GTPase activities
CP974_RS02005	COG1470	cell adhesion involved in biofilm formation
CP974_RS02050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP974_RS02060	COG2909	trisaccharide binding
CP974_RS02060	COG2909	trisaccharide binding
CP974_RS02075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP974_RS02095	COG0204	Acyl-transferase
CP974_RS02135	COG0671	phosphoesterase, PA-phosphatase related
CP974_RS02140	COG1309	transcriptional regulator
CP974_RS02150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP974_RS02165	COG2706	6-phosphogluconolactonase activity
CP974_RS02175	COG4948	Mandelate Racemase Muconate Lactonizing
CP974_RS02190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP974_RS02200	COG0395	ABC-type sugar transport system, permease component
CP974_RS02205	COG1175	transmembrane transport
CP974_RS02225	COG0546	phosphoglycolate phosphatase activity
CP974_RS02230	COG3842	ATPase activity
CP974_RS02235	COG1178	ABC-type Fe3 transport system permease component
CP974_RS02260	COG2226	methyltransferase
CP974_RS02270	COG4981	capsule polysaccharide biosynthetic process
CP974_RS02280	COG0438	transferase activity, transferring glycosyl groups
CP974_RS02300	COG3693	PFAM glycoside hydrolase, family 10
CP974_RS02305	COG0395	ABC-type sugar transport system, permease component
CP974_RS02310	COG1175	transmembrane transport
CP974_RS02325	COG1609	Transcriptional regulator
CP974_RS02335	COG3507	Belongs to the glycosyl hydrolase 43 family
CP974_RS02350	COG2160	L-arabinose isomerase activity
CP974_RS02360	COG1609	Transcriptional regulator
CP974_RS02370	COG1129	ABC transporter
CP974_RS02375	COG4214	carbohydrate transport
CP974_RS02385	COG0326	Molecular chaperone. Has ATPase activity
CP974_RS02400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP974_RS02410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS02430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CP974_RS02435	COG0297	glycogen (starch) synthase activity
CP974_RS02460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP974_RS02490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CP974_RS02500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP974_RS02515	COG0432	Pfam Uncharacterised protein family UPF0047
CP974_RS02525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP974_RS02530	COG1132	(ABC) transporter
CP974_RS02535	COG1846	Transcriptional regulator
CP974_RS02550	COG1132	(ABC) transporter
CP974_RS02555	COG1132	(ABC) transporter
CP974_RS02575	COG0386	Belongs to the glutathione peroxidase family
CP974_RS02585	COG1136	(ABC) transporter
CP974_RS02585	COG0577	efflux transmembrane transporter activity
CP974_RS02595	COG1653	transport
CP974_RS02600	COG0366	Alpha amylase catalytic
CP974_RS02605	COG1653	transport
CP974_RS02610	COG1175	transmembrane transport
CP974_RS02615	COG0395	ABC-type sugar transport system, permease component
CP974_RS02620	COG1960	acyl-CoA dehydrogenase activity
CP974_RS02630	COG0242	peptide deformylase activity
CP974_RS02640	COG3442	glutamine amidotransferase
CP974_RS02645	COG0205	6-phosphofructokinase activity
CP974_RS02700	COG0740	serine-type endopeptidase activity
CP974_RS02725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP974_RS02730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP974_RS02735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP974_RS02745	COG2226	methyltransferase
CP974_RS02810	COG0443	Heat shock 70 kDa protein
CP974_RS02815	COG0443	Heat shock 70 kDa protein
CP974_RS02905	COG2124	cytochrome p450
CP974_RS02915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP974_RS02920	COG3663	DNA glycosylase
CP974_RS02930	COG1940	carbohydrate kinase activity
CP974_RS02935	COG2188	Transcriptional regulator
CP974_RS02975	COG1522	sequence-specific DNA binding
CP974_RS02980	COG0419	ATPase involved in DNA repair
CP974_RS02985	COG0420	3'-5' exonuclease activity
CP974_RS03000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP974_RS03000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CP974_RS03005	COG4232	protein-disulfide reductase activity
CP974_RS03010	COG1739	Uncharacterized protein family UPF0029
CP974_RS03020	COG1832	CoA-binding protein
CP974_RS03050	COG3953	SLT domain
CP974_RS03050	COG5280	Phage tail tape measure protein TP901
CP974_RS03085	COG4214	carbohydrate transport
CP974_RS03095	COG4213	ABC transporter substrate-binding protein
CP974_RS03105	COG0110	maltose O-acetyltransferase activity
CP974_RS03140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP974_RS03155	COG1968	undecaprenyl-diphosphatase activity
CP974_RS03170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP974_RS03175	COG0673	inositol 2-dehydrogenase activity
CP974_RS03195	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP974_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS03290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP974_RS03290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP974_RS03325	COG1716	ATPase activity
CP974_RS03345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP974_RS03375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP974_RS03385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP974_RS03400	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CP974_RS03450	COG2814	Major facilitator Superfamily
CP974_RS03455	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CP974_RS03460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CP974_RS03465	COG1984	allophanate hydrolase subunit 2
CP974_RS03495	COG2364	Membrane
CP974_RS03505	COG2270	Major facilitator Superfamily
CP974_RS03520	COG1216	Glycosyl transferase, family 2
CP974_RS03540	COG1960	acyl-CoA dehydrogenase activity
CP974_RS03575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP974_RS03610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP974_RS03615	COG0140	phosphoribosyl-ATP diphosphatase activity
CP974_RS03620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP974_RS03625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP974_RS03625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP974_RS03630	COG3201	nicotinamide mononucleotide transporter
CP974_RS03650	COG1595	DNA-templated transcription, initiation
CP974_RS03655	COG1090	epimerase
CP974_RS03660	COG1940	carbohydrate kinase activity
CP974_RS03660	COG1846	Transcriptional regulator
CP974_RS03670	COG2233	PERMEase
CP974_RS03680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP974_RS03690	COG0531	amino acid
CP974_RS03700	COG1366	Belongs to the anti-sigma-factor antagonist family
CP974_RS03705	COG1366	Belongs to the anti-sigma-factor antagonist family
CP974_RS03710	COG2172	sigma factor antagonist activity
CP974_RS03720	COG2770	Histidine kinase
CP974_RS03720	COG2208	phosphoserine phosphatase activity
CP974_RS03730	COG1191	sigma factor activity
CP974_RS03740	COG2390	Transcriptional regulator
CP974_RS03745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP974_RS03755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP974_RS03770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP974_RS03795	COG0284	orotidine-5'-phosphate decarboxylase activity
CP974_RS03800	COG0167	dihydroorotate dehydrogenase activity
CP974_RS03805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP974_RS03810	COG0505	Belongs to the CarA family
CP974_RS03820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP974_RS03825	COG0540	Belongs to the ATCase OTCase family
CP974_RS03830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CP974_RS03840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP974_RS03845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP974_RS03850	COG0006	proline dipeptidase activity
CP974_RS03860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP974_RS03865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP974_RS03870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP974_RS03875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP974_RS03880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP974_RS03890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP974_RS03895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP974_RS03910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP974_RS03930	COG0124	histidyl-tRNA synthetase
CP974_RS03945	COG1196	nuclear chromosome segregation
CP974_RS03950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP974_RS03960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP974_RS03965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP974_RS03970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP974_RS03980	COG2255	four-way junction helicase activity
CP974_RS03985	COG0632	four-way junction helicase activity
CP974_RS03990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP974_RS03995	COG0217	transcriptional regulatory protein
CP974_RS04000	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CP974_RS04005	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CP974_RS04020	COG0438	transferase activity, transferring glycosyl groups
CP974_RS04025	COG1560	Kdo2-lipid A biosynthetic process
CP974_RS04030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP974_RS04050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP974_RS04065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP974_RS04120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP974_RS04165	COG1648	precorrin-2 dehydrogenase activity
CP974_RS04165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP974_RS04170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP974_RS04185	COG1464	Belongs to the NlpA lipoprotein family
CP974_RS04190	COG2011	ABC-type metal ion transport system permease component
CP974_RS04195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP974_RS04215	COG0584	glycerophosphoryl diester phosphodiesterase
CP974_RS04225	COG0477	Major facilitator Superfamily
CP974_RS04235	COG0165	Argininosuccinate lyase
CP974_RS04240	COG0137	argininosuccinate synthase activity
CP974_RS04250	COG1438	arginine binding
CP974_RS04255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP974_RS04260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP974_RS04265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP974_RS04270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP974_RS04280	COG3851	Histidine kinase
CP974_RS04285	COG2197	response regulator
CP974_RS04300	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CP974_RS04305	COG3903	Transcriptional regulator
CP974_RS04305	COG2197	response regulator
CP974_RS04325	COG2813	Specifically methylates the guanine in position
CP974_RS04345	COG1649	PFAM Uncharacterised BCR, COG1649
CP974_RS04360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP974_RS04360	COG0072	phenylalanine-tRNA ligase activity
CP974_RS04365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP974_RS04370	COG5002	protein histidine kinase activity
CP974_RS04375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP974_RS04380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP974_RS04385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP974_RS04390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP974_RS04435	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS04440	COG0174	glutamine synthetase
CP974_RS04455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CP974_RS04480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP974_RS04505	COG0805	protein transport
CP974_RS04510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP974_RS04530	COG2378	regulation of single-species biofilm formation
CP974_RS04540	COG0545	Peptidyl-prolyl cis-trans isomerase
CP974_RS04545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP974_RS04555	COG1609	Transcriptional regulator
CP974_RS04560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP974_RS04565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP974_RS04580	COG4122	O-methyltransferase activity
CP974_RS04585	COG1222	aaa ATPase
CP974_RS04605	COG1994	Peptidase M50
CP974_RS04605	COG0517	IMP dehydrogenase activity
CP974_RS04615	COG2197	response regulator
CP974_RS04620	COG4166	transmembrane transport
CP974_RS04635	COG0646	methionine synthase
CP974_RS04635	COG1410	methionine synthase
CP974_RS04640	COG1414	Transcriptional regulator
CP974_RS04645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP974_RS04650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP974_RS04655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP974_RS04665	COG0215	cysteine-tRNA ligase activity
CP974_RS04685	COG0598	Magnesium transport protein CorA
CP974_RS04695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP974_RS04700	COG0667	Aldo Keto reductase
CP974_RS04730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP974_RS04750	COG1070	Carbohydrate kinase
CP974_RS04755	COG1501	Belongs to the glycosyl hydrolase 31 family
CP974_RS04770	COG3265	gluconokinase activity
CP974_RS04785	COG3573	Dehydrogenase
CP974_RS04790	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP974_RS04795	COG2149	membrane
CP974_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS04845	COG3876	Protein conserved in bacteria
CP974_RS04900	COG1960	acyl-CoA dehydrogenase activity
CP974_RS04910	COG0640	Transcriptional regulator
CP974_RS04940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP974_RS04945	COG2188	Transcriptional regulator
CP974_RS04970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP974_RS04980	COG2755	lipolytic protein G-D-S-L family
CP974_RS04995	COG0456	acetyltransferase
CP974_RS05005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CP974_RS05015	COG0587	DNA-directed DNA polymerase activity
CP974_RS05030	COG1799	cell septum assembly
CP974_RS05035	COG1960	acyl-CoA dehydrogenase activity
CP974_RS05040	COG0477	Major facilitator Superfamily
CP974_RS05045	COG0671	phosphoesterase, PA-phosphatase related
CP974_RS05055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP974_RS05065	COG0438	transferase activity, transferring glycosyl groups
CP974_RS05085	COG0411	ABC transporter
CP974_RS05090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CP974_RS05095	COG3583	domain protein
CP974_RS05110	COG1160	GTP binding
CP974_RS05120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP974_RS05145	COG0494	nUDIX hydrolase
CP974_RS05150	COG1187	pseudouridine synthase activity
CP974_RS05155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP974_RS05160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP974_RS05175	COG0686	Belongs to the AlaDH PNT family
CP974_RS05185	COG0494	nUDIX hydrolase
CP974_RS05190	COG0504	CTP synthase activity
CP974_RS05195	COG3387	PFAM Glycoside hydrolase 15-related
CP974_RS05200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP974_RS05205	COG0297	glycogen (starch) synthase activity
CP974_RS05215	COG0497	DNA recombination
CP974_RS05220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP974_RS05235	COG1120	ATPase activity
CP974_RS05240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP974_RS05245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP974_RS05250	COG0647	UMP catabolic process
CP974_RS05285	COG2094	Belongs to the DNA glycosylase MPG family
CP974_RS05295	COG1881	PFAM PEBP family protein
CP974_RS05320	COG1119	ATPase activity
CP974_RS05330	COG2197	response regulator
CP974_RS05335	COG4585	Histidine kinase
CP974_RS05345	COG1131	(ABC) transporter
CP974_RS05345	COG1716	ATPase activity
CP974_RS05345	COG0842	Transport permease protein
CP974_RS05350	COG0560	Phosphoserine phosphatase
CP974_RS05350	COG3830	Belongs to the UPF0237 family
CP974_RS05385	COG2186	Transcriptional regulator
CP974_RS05395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CP974_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS05405	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
CP974_RS05445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP974_RS05465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP974_RS05470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP974_RS05485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP974_RS05525	COG3387	PFAM Glycoside hydrolase 15-related
CP974_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS05535	COG1024	Enoyl-CoA hydratase
CP974_RS05545	COG0488	(ABC) transporter
CP974_RS05565	COG0235	Class ii aldolase
CP974_RS05580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CP974_RS05585	COG1492	cobalamin metabolic process
CP974_RS05595	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CP974_RS05600	COG1797	cobyrinic acid a,c-diamide synthase activity
CP974_RS05635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CP974_RS05640	COG0583	DNA-binding transcription factor activity
CP974_RS05650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP974_RS05665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP974_RS05675	COG0346	lactoylglutathione lyase activity
CP974_RS05685	COG1414	Transcriptional regulator
CP974_RS05700	COG4585	Histidine kinase
CP974_RS05705	COG2197	response regulator
CP974_RS05715	COG3866	Pectate lyase
CP974_RS05720	COG2755	lipolytic protein G-D-S-L family
CP974_RS05750	COG0395	ABC-type sugar transport system, permease component
CP974_RS05755	COG1175	transmembrane transport
CP974_RS05770	COG1802	Transcriptional regulator
CP974_RS05780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP974_RS05825	COG4974	Belongs to the 'phage' integrase family
CP974_RS05940	COG4695	Portal protein
CP974_RS06015	COG1051	belongs to the nudix hydrolase family
CP974_RS06120	COG0305	Participates in initiation and elongation during chromosome replication
CP974_RS06130	COG1846	Transcriptional regulator
CP974_RS06250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP974_RS06260	COG2171	N-acyltransferase activity
CP974_RS06280	COG0822	iron-sulfur transferase activity
CP974_RS06285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP974_RS06290	COG0396	ATPase activity
CP974_RS06300	COG0719	Fe-S assembly protein
CP974_RS06315	COG1131	(ABC) transporter
CP974_RS06325	COG1612	heme a metabolic process
CP974_RS06335	COG0109	protoheme IX farnesyltransferase activity
CP974_RS06345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP974_RS06360	COG0363	glucosamine-6-phosphate deaminase activity
CP974_RS06380	COG0166	Belongs to the GPI family
CP974_RS06390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP974_RS06395	COG0149	triose-phosphate isomerase activity
CP974_RS06400	COG0126	phosphoglycerate kinase activity
CP974_RS06405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP974_RS06410	COG1481	regulation of sporulation
CP974_RS06415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP974_RS06420	COG1660	Displays ATPase and GTPase activities
CP974_RS06425	COG0322	excinuclease ABC activity
CP974_RS06435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP974_RS06450	COG0477	Major facilitator Superfamily
CP974_RS06470	COG0556	nucleotide-excision repair
CP974_RS06490	COG2313	pseudouridylate synthase activity
CP974_RS06495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP974_RS06520	COG0436	Aminotransferase
CP974_RS06540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP974_RS06555	COG0237	dephospho-CoA kinase activity
CP974_RS06570	COG2226	methyltransferase
CP974_RS06575	COG1643	Atp-dependent helicase
CP974_RS06600	COG2050	protein possibly involved in aromatic compounds catabolism
CP974_RS06680	COG2304	oxidoreductase activity
CP974_RS06690	COG0067	glutamate synthase
CP974_RS06690	COG0069	glutamate synthase activity
CP974_RS06690	COG0070	glutamate synthase
CP974_RS06700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP974_RS06705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP974_RS06715	COG0159	tryptophan synthase activity
CP974_RS06720	COG0133	tryptophan synthase activity
CP974_RS06730	COG0134	indole-3-glycerol-phosphate synthase activity
CP974_RS06750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP974_RS06755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP974_RS06770	COG0107	imidazoleglycerol-phosphate synthase activity
CP974_RS06775	COG0251	oxidation-reduction process
CP974_RS06780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP974_RS06785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP974_RS06790	COG0131	Imidazoleglycerol-phosphate dehydratase
CP974_RS06795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP974_RS06800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP974_RS06840	COG1432	Conserved Protein
CP974_RS06845	COG0587	DNA-directed DNA polymerase activity
CP974_RS06920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP974_RS06930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP974_RS06935	COG3599	regulation of cell shape
CP974_RS06945	COG1799	cell septum assembly
CP974_RS06950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CP974_RS06955	COG1496	oxidoreductase activity
CP974_RS06965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP974_RS06970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP974_RS06980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP974_RS06985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP974_RS06995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP974_RS07000	COG0768	penicillin binding
CP974_RS07010	COG0275	rRNA processing
CP974_RS07020	COG0714	Associated with various cellular activities
CP974_RS07040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP974_RS07050	COG1511	domain protein
CP974_RS07055	COG1309	transcriptional regulator
CP974_RS07060	COG1233	COG1233 Phytoene dehydrogenase and related
CP974_RS07090	COG2022	thiamine diphosphate biosynthetic process
CP974_RS07090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP974_RS07100	COG2022	thiamine diphosphate biosynthetic process
CP974_RS07105	COG0515	serine threonine protein kinase
CP974_RS07105	COG2815	serine threonine protein kinase
CP974_RS07110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CP974_RS07115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP974_RS07120	COG2193	ferroxidase activity
CP974_RS07125	COG0243	molybdopterin cofactor binding
CP974_RS07130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP974_RS07155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP974_RS07165	COG4585	Histidine kinase
CP974_RS07190	COG1940	carbohydrate kinase activity
CP974_RS07200	COG0003	Pfam Anion-transporting ATPase
CP974_RS07220	COG0438	transferase activity, transferring glycosyl groups
CP974_RS07265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP974_RS07270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP974_RS07275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP974_RS07280	COG0723	plastoquinol--plastocyanin reductase activity
CP974_RS07285	COG2010	Cytochrome c
CP974_RS07290	COG1845	cytochrome c oxidase, subunit III
CP974_RS07300	COG1376	ErfK ybiS ycfS ynhG family protein
CP974_RS07310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP974_RS07315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP974_RS07325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP974_RS07350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CP974_RS07355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP974_RS07360	COG2197	response regulator
CP974_RS07365	COG4585	Histidine kinase
CP974_RS07390	COG1132	(ABC) transporter
CP974_RS07395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP974_RS07410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP974_RS07425	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CP974_RS07430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP974_RS07435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP974_RS07440	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP974_RS07450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP974_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS07505	COG0321	lipoyl(octanoyl) transferase activity
CP974_RS07510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP974_RS07540	COG0596	Alpha beta hydrolase
CP974_RS07545	COG1846	Transcriptional regulator
CP974_RS07615	COG0366	Alpha amylase catalytic
CP974_RS07620	COG3833	ABC-type maltose transport systems, permease component
CP974_RS07625	COG1175	transmembrane transport
CP974_RS07630	COG1653	transport
CP974_RS07640	COG1609	Transcriptional regulator
CP974_RS07650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP974_RS07660	COG0174	glutamine synthetase
CP974_RS07695	COG2267	carboxylic ester hydrolase activity
CP974_RS07720	COG2132	Multicopper oxidase
CP974_RS07725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP974_RS07725	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP974_RS07735	COG0477	Major facilitator Superfamily
CP974_RS07740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP974_RS07745	COG1994	Peptidase M50
CP974_RS07815	COG2814	Major facilitator Superfamily
CP974_RS07825	COG3540	Alkaline phosphatase
CP974_RS07830	COG0384	phenazine biosynthesis protein PhzF
CP974_RS07850	COG2319	Wd-40 repeat
CP974_RS07850	COG4249	Peptidase C14 caspase catalytic subunit p20
CP974_RS07875	COG1476	TRANSCRIPTIONal
CP974_RS07905	COG3022	response to hydroperoxide
CP974_RS07910	COG0800	Aldolase
CP974_RS07925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP974_RS07945	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP974_RS07970	COG0438	transferase activity, transferring glycosyl groups
CP974_RS07975	COG1309	transcriptional regulator
CP974_RS08000	COG3845	ABC transporter
CP974_RS08015	COG4122	O-methyltransferase activity
CP974_RS08035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP974_RS08050	COG4991	sh3 domain protein
CP974_RS08145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP974_RS08180	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CP974_RS08250	COG0739	heme binding
CP974_RS08595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP974_RS08605	COG0477	Major facilitator Superfamily
CP974_RS08610	COG1309	transcriptional regulator
CP974_RS08625	COG4585	Histidine kinase
CP974_RS08630	COG2197	response regulator
CP974_RS08645	COG0667	Aldo Keto reductase
CP974_RS08650	COG0789	Transcriptional regulator
CP974_RS08660	COG1741	Belongs to the pirin family
CP974_RS08675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS08680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP974_RS08685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP974_RS08725	COG2130	NADP-dependent
CP974_RS08740	COG1077	Cell shape determining protein MreB Mrl
CP974_RS08745	COG0318	PFAM AMP-dependent synthetase and ligase
CP974_RS08750	COG0825	malonyl-CoA metabolic process
CP974_RS08750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP974_RS08755	COG1846	Transcriptional regulator
CP974_RS08760	COG1764	response to oxidative stress
CP974_RS08780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP974_RS08795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CP974_RS08840	COG1070	Carbohydrate kinase
CP974_RS08860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP974_RS08865	COG0358	DNA primase activity
CP974_RS08875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP974_RS08900	COG0243	molybdopterin cofactor binding
CP974_RS08935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP974_RS08940	COG2146	nitrite reductase [NAD(P)H] activity
CP974_RS08940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP974_RS08945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP974_RS08945	COG2146	nitrite reductase [NAD(P)H] activity
CP974_RS08970	COG0574	Belongs to the PEP-utilizing enzyme family
CP974_RS08970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP974_RS08985	COG0423	glycine-tRNA ligase activity
CP974_RS08990	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP974_RS08990	COG3443	Belongs to the bacterial solute-binding protein 9 family
CP974_RS09000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP974_RS09010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP974_RS09015	COG1381	Involved in DNA repair and RecF pathway recombination
CP974_RS09030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP974_RS09045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP974_RS09060	COG2315	Protein conserved in bacteria
CP974_RS09070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP974_RS09080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP974_RS09085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP974_RS09090	COG1234	tRNA 3'-trailer cleavage
CP974_RS09095	COG0537	adenosine 5'-monophosphoramidase activity
CP974_RS09110	COG2070	2-Nitropropane dioxygenase
CP974_RS09115	COG0484	heat shock protein binding
CP974_RS09120	COG1420	regulation of RNA biosynthetic process
CP974_RS09145	COG0481	GTPase activity
CP974_RS09150	COG0268	Binds directly to 16S ribosomal RNA
CP974_RS09170	COG1234	tRNA 3'-trailer cleavage
CP974_RS09180	COG1555	photosystem II stabilization
CP974_RS09180	COG1596	polysaccharide export
CP974_RS09185	COG1307	EDD domain protein, DegV family
CP974_RS09195	COG0495	leucyl-tRNA aminoacylation
CP974_RS09210	COG5650	phosphatidylinositol metabolic process
CP974_RS09225	COG0588	phosphoglycerate mutase activity
CP974_RS09230	COG0799	negative regulation of ribosome biogenesis
CP974_RS09240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP974_RS09245	COG0501	Belongs to the peptidase M48B family
CP974_RS09260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP974_RS09270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP974_RS09290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP974_RS09295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP974_RS09300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP974_RS09315	COG3209	COG3209 Rhs family protein
CP974_RS09330	COG0463	Glycosyl transferase, family 2
CP974_RS09345	COG0438	transferase activity, transferring glycosyl groups
CP974_RS09390	COG0673	inositol 2-dehydrogenase activity
CP974_RS09400	COG1530	ribonuclease E activity
CP974_RS09425	COG3226	Transcriptional regulator
CP974_RS09440	COG0772	Belongs to the SEDS family
CP974_RS09445	COG0768	penicillin binding
CP974_RS09460	COG1077	Cell shape determining protein MreB Mrl
CP974_RS09465	COG0105	UTP biosynthetic process
CP974_RS09475	COG0285	dihydrofolate synthase activity
CP974_RS09480	COG0525	valine-tRNA ligase activity
CP974_RS09490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP974_RS09495	COG0740	serine-type endopeptidase activity
CP974_RS09500	COG0740	serine-type endopeptidase activity
CP974_RS09505	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP974_RS09525	COG3594	Acyltransferase
CP974_RS09545	COG4552	Acetyltransferase involved in intracellular survival and related
CP974_RS09565	COG1113	amino acid transport
CP974_RS09570	COG1268	BioY protein
CP974_RS09575	COG1113	amino acid transport
CP974_RS09580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CP974_RS09585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP974_RS09635	COG0697	spore germination
CP974_RS09640	COG1846	Transcriptional regulator
CP974_RS09670	COG0668	transmembrane transport
CP974_RS09695	COG1486	melibiose metabolic process
CP974_RS09725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP974_RS09730	COG3415	Transposase
CP974_RS09730	COG2801	Transposase and inactivated derivatives
CP974_RS09735	COG2346	COG2346, Truncated hemoglobins
CP974_RS09760	COG0629	single-stranded DNA binding
CP974_RS09845	COG1061	Type III restriction enzyme res subunit
CP974_RS09895	COG1595	DNA-templated transcription, initiation
CP974_RS09910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP974_RS09965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP974_RS09985	COG0673	inositol 2-dehydrogenase activity
CP974_RS09990	COG1609	Transcriptional regulator
CP974_RS10010	COG3250	beta-galactosidase activity
CP974_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS10045	COG1472	Belongs to the glycosyl hydrolase 3 family
CP974_RS10080	COG2356	endonuclease I
CP974_RS10085	COG0028	Belongs to the TPP enzyme family
CP974_RS10115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CP974_RS10170	COG1946	Acyl-CoA thioesterase
CP974_RS10195	COG1309	transcriptional regulator
CP974_RS10200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP974_RS10215	COG1960	acyl-CoA dehydrogenase activity
CP974_RS10230	COG0076	glutamate decarboxylase activity
CP974_RS10235	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP974_RS10255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP974_RS10265	COG0589	response to stress
CP974_RS10270	COG4977	sequence-specific DNA binding
CP974_RS10275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CP974_RS10300	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP974_RS10325	COG1136	(ABC) transporter
CP974_RS10340	COG4733	cellulase activity
CP974_RS10340	COG5297	Belongs to the glycosyl hydrolase family 6
CP974_RS10345	COG5297	Belongs to the glycosyl hydrolase family 6
CP974_RS10385	COG0395	ABC-type sugar transport system, permease component
CP974_RS10415	COG0588	phosphoglycerate mutase activity
CP974_RS10465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP974_RS10475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP974_RS10480	COG0765	amino acid transport
CP974_RS10485	COG0765	amino acid transport
CP974_RS10490	COG1126	abc transporter atp-binding protein
CP974_RS10545	COG0673	inositol 2-dehydrogenase activity
CP974_RS10575	COG2733	membrane
CP974_RS10585	COG4555	ABC transporter
CP974_RS10600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP974_RS10640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP974_RS10650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP974_RS10655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP974_RS10660	COG1263	PTS System
CP974_RS10665	COG1263	PTS System
CP974_RS10670	COG1234	tRNA 3'-trailer cleavage
CP974_RS10695	COG1113	amino acid transport
CP974_RS10700	COG1115	amino acid carrier protein
CP974_RS10710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP974_RS10720	COG1335	isochorismatase
CP974_RS10760	COG0277	FAD linked oxidase domain protein
CP974_RS10770	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP974_RS10795	COG3654	unkown
CP974_RS10865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP974_RS10880	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP974_RS10890	COG1678	Uncharacterized ACR, COG1678
CP974_RS10895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP974_RS10900	COG0776	regulation of translation
CP974_RS10910	COG3973	AAA domain
CP974_RS10925	COG2223	nitrite transmembrane transporter activity
CP974_RS10930	COG0583	DNA-binding transcription factor activity
CP974_RS10950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP974_RS10955	COG3409	Peptidoglycan-binding domain 1 protein
CP974_RS10955	COG0793	Belongs to the peptidase S41A family
CP974_RS10960	COG2177	Part of the ABC transporter FtsEX involved in
CP974_RS10965	COG2884	Cell division ATP-binding protein ftsE
CP974_RS10980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP974_RS10985	COG0515	serine threonine protein kinase
CP974_RS10990	COG0515	serine threonine protein kinase
CP974_RS11000	COG1653	transport
CP974_RS11005	COG1175	transmembrane transport
CP974_RS11010	COG0395	ABC-type sugar transport system, permease component
CP974_RS11015	COG1309	transcriptional regulator
CP974_RS11035	COG2902	Dehydrogenase
CP974_RS11060	COG0653	protein targeting
CP974_RS11070	COG3214	Protein conserved in bacteria
CP974_RS11080	COG2197	response regulator
CP974_RS11085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP974_RS11095	COG0823	Involved in the tonB-independent uptake of proteins
CP974_RS11100	COG5000	phosphorelay sensor kinase activity
CP974_RS11100	COG5002	protein histidine kinase activity
CP974_RS11105	COG0745	RESPONSE REGULATOR receiver
CP974_RS11110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CP974_RS11130	COG0714	Associated with various cellular activities
CP974_RS11170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP974_RS11180	COG1482	cell wall glycoprotein biosynthetic process
CP974_RS11195	COG2835	tetraacyldisaccharide 4'-kinase activity
CP974_RS11200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP974_RS11235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP974_RS11240	COG0778	Nitroreductase
CP974_RS11240	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CP974_RS11265	COG1316	TRANSCRIPTIONal
CP974_RS11270	COG1316	TRANSCRIPTIONal
CP974_RS11275	COG1316	TRANSCRIPTIONal
CP974_RS11280	COG1316	TRANSCRIPTIONal
CP974_RS11285	COG1607	acyl-coa hydrolase
CP974_RS11290	COG1316	TRANSCRIPTIONal
CP974_RS11300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS11305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS11315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP974_RS11335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP974_RS11345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CP974_RS11360	COG2205	protein histidine kinase activity
CP974_RS11365	COG0745	RESPONSE REGULATOR receiver
CP974_RS11370	COG3104	oligopeptide transport
CP974_RS11375	COG1316	TRANSCRIPTIONal
CP974_RS11430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CP974_RS11435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP974_RS11440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP974_RS11450	COG1366	Belongs to the anti-sigma-factor antagonist family
CP974_RS11455	COG1191	sigma factor activity
CP974_RS11470	COG1228	amidohydrolase
CP974_RS11485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CP974_RS11490	COG0019	diaminopimelate decarboxylase activity
CP974_RS11550	COG2755	lipolytic protein G-D-S-L family
CP974_RS11555	COG0183	Belongs to the thiolase family
CP974_RS11580	COG1136	(ABC) transporter
CP974_RS11580	COG0577	efflux transmembrane transporter activity
CP974_RS11590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP974_RS11595	COG1252	NADH dehydrogenase
CP974_RS11635	COG0148	phosphopyruvate hydratase activity
CP974_RS11650	COG1652	LysM domain
CP974_RS11655	COG2124	cytochrome p450
CP974_RS11675	COG0463	Glycosyl transferase, family 2
CP974_RS11700	COG2815	serine threonine protein kinase
CP974_RS11700	COG0515	serine threonine protein kinase
CP974_RS11795	COG4585	Histidine kinase
CP974_RS11805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP974_RS11810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP974_RS11815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP974_RS11820	COG0193	aminoacyl-tRNA hydrolase activity
CP974_RS11835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CP974_RS11850	COG4106	trans-aconitate 2-methyltransferase activity
CP974_RS11855	COG1846	Transcriptional regulator
CP974_RS11860	COG2197	response regulator
CP974_RS11865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP974_RS11895	COG0488	(ABC) transporter
CP974_RS11915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP974_RS11920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP974_RS11930	COG0084	hydrolase, TatD family'
CP974_RS11955	COG5297	Belongs to the glycosyl hydrolase family 6
CP974_RS11955	COG4733	cellulase activity
CP974_RS11970	COG2409	Drug exporters of the RND superfamily
CP974_RS11980	COG4946	Tricorn protease homolog
CP974_RS11980	COG0793	Belongs to the peptidase S41A family
CP974_RS11985	COG2318	DinB family
CP974_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS12005	COG2072	flavoprotein involved in K transport
CP974_RS12045	COG0708	Exodeoxyribonuclease III
CP974_RS12060	COG0252	asparaginase activity
CP974_RS12185	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP974_RS12190	COG0315	cyclic pyranopterin monophosphate synthase activity
CP974_RS12200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP974_RS12205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP974_RS12230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP974_RS12255	COG3191	aminopeptidase activity
CP974_RS12265	COG0477	Major facilitator Superfamily
CP974_RS12290	COG3384	dioxygenase
CP974_RS12295	COG1846	Transcriptional regulator
CP974_RS12440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP974_RS12445	COG1120	ATPase activity
CP974_RS12455	COG0546	phosphoglycolate phosphatase activity
CP974_RS12470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP974_RS12515	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CP974_RS12530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CP974_RS12535	COG0475	glutathione-regulated potassium exporter activity
CP974_RS12550	COG3629	intracellular signal transduction
CP974_RS12550	COG3903	Transcriptional regulator
CP974_RS12605	COG1695	Transcriptional regulator
CP974_RS12625	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP974_RS12640	COG2318	DinB family
CP974_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS12705	COG1309	transcriptional regulator
CP974_RS12710	COG0259	pyridoxamine-phosphate oxidase activity
CP974_RS12745	COG1366	Belongs to the anti-sigma-factor antagonist family
CP974_RS12795	COG1131	(ABC) transporter
CP974_RS12805	COG2945	thiolester hydrolase activity
CP974_RS12805	COG0596	Alpha beta hydrolase
CP974_RS12815	COG4821	SIS domain
CP974_RS12825	COG0259	pyridoxamine-phosphate oxidase activity
CP974_RS12845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP974_RS12860	COG1024	Enoyl-CoA hydratase
CP974_RS12870	COG5006	permease, DMT superfamily
CP974_RS12875	COG0247	lactate metabolic process
CP974_RS12875	COG0277	FAD linked oxidase domain protein
CP974_RS12880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP974_RS12915	COG2175	clavaminate synthase activity
CP974_RS12920	COG0527	aspartate kinase activity
CP974_RS12925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CP974_RS12930	COG0697	spore germination
CP974_RS12935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP974_RS12950	COG0583	DNA-binding transcription factor activity
CP974_RS12970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP974_RS12975	COG0494	nUDIX hydrolase
CP974_RS13020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP974_RS13035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CP974_RS13040	COG1737	Transcriptional regulator
CP974_RS13070	COG3142	Participates in the control of copper homeostasis
CP974_RS13120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CP974_RS13125	COG1061	Type III restriction enzyme res subunit
CP974_RS13165	COG1131	(ABC) transporter
CP974_RS13170	COG3973	AAA domain
CP974_RS13185	COG1278	Cold shock
CP974_RS13200	COG2814	Major facilitator Superfamily
CP974_RS13210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP974_RS13215	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP974_RS13230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP974_RS13240	COG2252	PERMEase
CP974_RS13280	COG0667	Aldo Keto reductase
CP974_RS13295	COG1115	amino acid carrier protein
CP974_RS13310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CP974_RS13320	COG0463	Glycosyl transferase, family 2
CP974_RS13325	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CP974_RS13345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP974_RS13385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP974_RS13415	COG2197	response regulator
CP974_RS13440	COG3842	ATPase activity
CP974_RS13450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP974_RS13465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP974_RS13470	COG0215	cysteine-tRNA ligase activity
CP974_RS13485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP974_RS13495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP974_RS13500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP974_RS13505	COG1329	Transcriptional regulator
CP974_RS13525	COG5002	protein histidine kinase activity
CP974_RS13560	COG0588	phosphoglycerate mutase activity
CP974_RS13575	COG0438	transferase activity, transferring glycosyl groups
CP974_RS13645	COG3973	AAA domain
CP974_RS13675	COG4552	Acetyltransferase involved in intracellular survival and related
CP974_RS13685	COG1490	D-aminoacyl-tRNA deacylase activity
CP974_RS13700	COG3485	protocatechuate 3,4-dioxygenase
CP974_RS13740	COG2897	thiosulfate sulfurtransferase activity
CP974_RS13770	COG1609	Transcriptional regulator
CP974_RS13775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP974_RS13790	COG0737	Belongs to the 5'-nucleotidase family
CP974_RS13795	COG0456	acetyltransferase
CP974_RS13815	COG0406	alpha-ribazole phosphatase activity
CP974_RS13815	COG0494	nUDIX hydrolase
CP974_RS13820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP974_RS13840	COG0306	phosphate transporter
CP974_RS13850	COG1937	Protein conserved in bacteria
CP974_RS13870	COG0671	phosphoesterase, PA-phosphatase related
CP974_RS13875	COG0739	heme binding
CP974_RS13875	COG0741	lytic transglycosylase activity
CP974_RS13875	COG1196	nuclear chromosome segregation
CP974_RS13930	COG1131	(ABC) transporter
CP974_RS13940	COG4585	Histidine kinase
CP974_RS13945	COG2197	response regulator
CP974_RS13950	COG0789	Transcriptional regulator
CP974_RS14020	COG0579	oxidoreductase
CP974_RS14025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP974_RS14035	COG0741	lytic transglycosylase activity
CP974_RS14035	COG1196	nuclear chromosome segregation
CP974_RS14035	COG0739	heme binding
CP974_RS14055	COG0513	Belongs to the DEAD box helicase family
CP974_RS14095	COG0785	Cytochrome C biogenesis protein
CP974_RS14100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CP974_RS14100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP974_RS14110	COG1643	Atp-dependent helicase
CP974_RS14145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP974_RS14165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP974_RS14170	COG0047	phosphoribosylformylglycinamidine synthase activity
CP974_RS14175	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP974_RS14205	COG4585	Histidine kinase
CP974_RS14210	COG2197	response regulator
CP974_RS14220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP974_RS14240	COG0151	Belongs to the GarS family
CP974_RS14370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP974_RS14380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP974_RS14420	COG1741	Belongs to the pirin family
CP974_RS14465	COG1960	acyl-CoA dehydrogenase activity
CP974_RS14475	COG1362	aminopeptidase activity
CP974_RS14500	COG0477	Major facilitator Superfamily
CP974_RS14510	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP974_RS14515	COG0022	dehydrogenase e1 component
CP974_RS14530	COG0515	serine threonine protein kinase
CP974_RS14535	COG0515	serine threonine protein kinase
CP974_RS14550	COG4591	ABC-type transport system involved in lipoprotein release permease component
CP974_RS14550	COG1136	(ABC) transporter
CP974_RS14570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP974_RS14600	COG1522	sequence-specific DNA binding
CP974_RS14605	COG1309	transcriptional regulator
CP974_RS14610	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP974_RS14635	COG3396	Phenylacetate-CoA oxygenase
CP974_RS14640	COG3460	Phenylacetate-CoA oxygenase
CP974_RS14645	COG3396	Phenylacetate-CoA oxygenase
CP974_RS14650	COG2151	metal-sulfur cluster biosynthetic enzyme
CP974_RS14655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP974_RS14680	COG1716	ATPase activity
CP974_RS14685	COG1716	ATPase activity
CP974_RS14700	COG0768	penicillin binding
CP974_RS14705	COG0515	serine threonine protein kinase
CP974_RS14710	COG3764	Sortase (surface protein transpeptidase)
CP974_RS14715	COG3764	Sortase (surface protein transpeptidase)
CP974_RS14735	COG0705	Rhomboid family
CP974_RS14770	COG0515	serine threonine protein kinase
CP974_RS14800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP974_RS14810	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CP974_RS14815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP974_RS14820	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP974_RS14825	COG0592	DNA-directed DNA polymerase activity
CP974_RS14840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CP974_RS14845	COG0594	ribonuclease P activity
CP974_RS14850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP974_RS14855	COG0706	membrane insertase activity
CP974_RS14865	COG0357	Ribosomal RNA small subunit methyltransferase G
CP974_RS14870	COG1192	Involved in chromosome partitioning
CP974_RS14885	COG3118	belongs to the thioredoxin family
CP974_RS14890	COG0492	ferredoxin-NADP+ reductase activity
CP974_RS14900	COG1595	DNA-templated transcription, initiation
CP974_RS14905	COG0515	serine threonine protein kinase
CP974_RS14905	COG2815	serine threonine protein kinase
CP974_RS14920	COG0617	tRNA 3'-terminal CCA addition
CP974_RS14930	COG1260	myo-inositol-1-phosphate synthase
CP974_RS14940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP974_RS14940	COG4499	WXG100 protein secretion system (Wss), protein YukC
CP974_RS14965	COG0360	Binds together with S18 to 16S ribosomal RNA
CP974_RS14970	COG0629	single-stranded DNA binding
CP974_RS14975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP974_RS14980	COG0359	binds to the 23S rRNA
CP974_RS14990	COG0305	Participates in initiation and elongation during chromosome replication
CP974_RS15020	COG0626	cystathionine gamma-synthase activity
CP974_RS15025	COG1950	PFAM Membrane protein of
CP974_RS15030	COG0662	Cupin 2, conserved barrel domain protein
CP974_RS15055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP974_RS15070	COG1609	Transcriptional regulator
CP974_RS15075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP974_RS15080	COG1271	oxidase subunit
CP974_RS15085	COG1294	oxidase, subunit
CP974_RS15090	COG4988	ABC transporter
CP974_RS15095	COG0739	heme binding
CP974_RS15095	COG1196	nuclear chromosome segregation
CP974_RS15095	COG0741	lytic transglycosylase activity
CP974_RS15100	COG0561	phosphatase activity
CP974_RS15115	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CP974_RS15120	COG0789	Transcriptional regulator
CP974_RS15140	COG1131	(ABC) transporter
CP974_RS15155	COG0561	phosphatase activity
CP974_RS15160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP974_RS15170	COG2837	iron assimilation
CP974_RS15175	COG2372	response to copper ion
CP974_RS15185	COG1999	signal sequence binding
CP974_RS15205	COG0006	proline dipeptidase activity
CP974_RS15220	COG0653	protein targeting
CP974_RS15235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP974_RS15245	COG1595	DNA-templated transcription, initiation
CP974_RS15250	COG0318	PFAM AMP-dependent synthetase and ligase
CP974_RS15290	COG0745	RESPONSE REGULATOR receiver
CP974_RS15295	COG0477	Major facilitator Superfamily
CP974_RS15320	COG1191	sigma factor activity
CP974_RS15325	COG1191	sigma factor activity
CP974_RS15355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP974_RS15380	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CP974_RS15400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP974_RS15455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP974_RS15460	COG1993	acr, cog1993
CP974_RS15465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP974_RS15520	COG1881	PFAM PEBP family protein
CP974_RS15535	COG0142	geranyltranstransferase activity
CP974_RS15545	COG1595	DNA-templated transcription, initiation
CP974_RS15580	COG1278	Cold shock
CP974_RS15600	COG3866	Pectate lyase
CP974_RS15635	COG2197	response regulator
CP974_RS15640	COG3851	Histidine kinase
CP974_RS15650	COG3263	regulation of cellular component size
CP974_RS15655	COG1253	flavin adenine dinucleotide binding
CP974_RS15675	COG4326	sporulation control protein
CP974_RS15775	COG2188	Transcriptional regulator
CP974_RS15850	COG0717	Belongs to the dCTP deaminase family
CP974_RS15870	COG2181	nitrate reductase activity
CP974_RS15870	COG0247	lactate metabolic process
CP974_RS15875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP974_RS15880	COG0443	Heat shock 70 kDa protein
CP974_RS15885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP974_RS15890	COG0484	heat shock protein binding
CP974_RS15895	COG0789	Transcriptional regulator
CP974_RS15925	COG0542	response to heat
CP974_RS15955	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP974_RS15970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP974_RS15975	COG0191	fructose-bisphosphate aldolase activity
CP974_RS15980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CP974_RS16005	COG3844	kynureninase activity
CP974_RS16015	COG4585	Histidine kinase
CP974_RS16020	COG2197	response regulator
CP974_RS16035	COG3559	Exporter of polyketide antibiotics
CP974_RS16040	COG1131	(ABC) transporter
CP974_RS16055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP974_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS16070	COG3321	synthase
CP974_RS16070	COG0604	alcohol dehydrogenase
CP974_RS16100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP974_RS16105	COG1309	transcriptional regulator
CP974_RS16155	COG2890	protein-(glutamine-N5) methyltransferase activity
CP974_RS16160	COG0693	protein deglycase activity
CP974_RS16165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP974_RS16170	COG1802	Transcriptional regulator
CP974_RS16185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP974_RS16190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP974_RS16210	COG1595	DNA-templated transcription, initiation
CP974_RS16255	COG1408	metallophosphoesterase
CP974_RS16260	COG1610	YqeY-like protein
CP974_RS16265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP974_RS16305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP974_RS16340	COG2267	carboxylic ester hydrolase activity
CP974_RS16350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP974_RS16355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP974_RS16415	COG1111	helicase
CP974_RS16415	COG1205	dead DEAH box helicase
CP974_RS16420	COG1366	Belongs to the anti-sigma-factor antagonist family
CP974_RS16425	COG2172	sigma factor antagonist activity
CP974_RS16430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP974_RS16440	COG2890	protein-(glutamine-N5) methyltransferase activity
CP974_RS16455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP974_RS16455	COG1754	DNA topoisomerase type I activity
CP974_RS16460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP974_RS16465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CP974_RS16505	COG0596	Alpha beta hydrolase
CP974_RS16510	COG2267	carboxylic ester hydrolase activity
CP974_RS16520	COG1733	regulation of RNA biosynthetic process
CP974_RS16525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP974_RS16530	COG1280	lysine exporter protein (LysE YggA)
CP974_RS16590	COG0728	peptidoglycan biosynthetic process
CP974_RS16600	COG0438	transferase activity, transferring glycosyl groups
CP974_RS16625	COG0492	ferredoxin-NADP+ reductase activity
CP974_RS16660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP974_RS16660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP974_RS16675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP974_RS16680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP974_RS16685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP974_RS16700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP974_RS16720	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS16725	COG2318	DinB family
CP974_RS16735	COG0789	Transcriptional regulator
CP974_RS16750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP974_RS16755	COG2027	D-alanyl-D-alanine carboxypeptidase
CP974_RS16765	COG0037	tRNA processing
CP974_RS16780	COG0302	gtp cyclohydrolase
CP974_RS16795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CP974_RS16810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP974_RS16810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP974_RS16825	COG1174	glycine betaine transport
CP974_RS16830	COG1174	glycine betaine transport
CP974_RS16845	COG0649	NAD binding
CP974_RS16860	COG2197	response regulator
CP974_RS16865	COG1660	Displays ATPase and GTPase activities
CP974_RS16875	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CP974_RS16885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP974_RS16900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP974_RS16925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CP974_RS16950	COG2027	D-alanyl-D-alanine carboxypeptidase
CP974_RS16955	COG0739	heme binding
CP974_RS16960	COG2205	protein histidine kinase activity
CP974_RS16965	COG0745	RESPONSE REGULATOR receiver
CP974_RS16980	COG1194	a g-specific adenine glycosylase
CP974_RS16995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CP974_RS17015	COG0248	Ppx GppA phosphatase
CP974_RS17020	COG1082	Xylose isomerase domain protein TIM barrel
CP974_RS17025	COG0129	dihydroxy-acid dehydratase activity
CP974_RS17035	COG4991	sh3 domain protein
CP974_RS17045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP974_RS17050	COG1335	isochorismatase
CP974_RS17060	COG0180	Tryptophanyl-tRNA synthetase
CP974_RS17080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP974_RS17135	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CP974_RS17140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP974_RS17145	COG0181	hydroxymethylbilane synthase activity
CP974_RS17150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP974_RS17150	COG1648	precorrin-2 dehydrogenase activity
CP974_RS17210	COG2318	DinB family
CP974_RS17240	COG3415	Transposase
CP974_RS17240	COG2801	Transposase and inactivated derivatives
CP974_RS17260	COG0596	Alpha beta hydrolase
CP974_RS17270	COG0113	porphobilinogen synthase activity
CP974_RS17280	COG1595	DNA-templated transcription, initiation
CP974_RS17310	COG2815	serine threonine protein kinase
CP974_RS17310	COG0515	serine threonine protein kinase
CP974_RS17315	COG0018	arginyl-trna synthetase
CP974_RS17320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP974_RS17340	COG1690	Belongs to the RtcB family
CP974_RS17385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP974_RS17390	COG0406	alpha-ribazole phosphatase activity
CP974_RS17410	COG1333	cytochrome c biogenesis protein
CP974_RS17415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP974_RS17445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CP974_RS17465	COG0163	prenyltransferase activity
CP974_RS17475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP974_RS17490	COG1301	dicarboxylic acid transport
CP974_RS17530	COG0501	Belongs to the peptidase M48B family
CP974_RS17540	COG1278	Cold shock
CP974_RS17545	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP974_RS17560	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP974_RS17570	COG2226	methyltransferase
CP974_RS17575	COG2226	methyltransferase
CP974_RS17610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP974_RS17620	COG0649	NAD binding
CP974_RS17630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP974_RS17635	COG1034	ATP synthesis coupled electron transport
CP974_RS17640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP974_RS17645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP974_RS17650	COG0839	Belongs to the complex I subunit 6 family
CP974_RS17655	COG0713	ATP synthesis coupled electron transport
CP974_RS17660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP974_RS17670	COG1007	ATP synthesis coupled electron transport
CP974_RS17685	COG2207	Transcriptional regulator
CP974_RS17695	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP974_RS17705	COG0142	geranyltranstransferase activity
CP974_RS17715	COG4935	Belongs to the peptidase S8 family
CP974_RS17715	COG2234	aminopeptidase activity
CP974_RS17730	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP974_RS17735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP974_RS17735	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP974_RS17760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP974_RS17765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP974_RS17770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP974_RS17775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP974_RS17780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP974_RS17785	COG0839	Belongs to the complex I subunit 6 family
CP974_RS17790	COG0713	ATP synthesis coupled electron transport
CP974_RS17795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP974_RS17805	COG1007	ATP synthesis coupled electron transport
CP974_RS17810	COG0501	Belongs to the peptidase M48B family
CP974_RS17815	COG3304	Inner membrane component domain
CP974_RS17830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP974_RS17835	COG1666	GTP binding
CP974_RS17855	COG0702	epimerase
CP974_RS17875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP974_RS17880	COG2030	dehydratase
CP974_RS17890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP974_RS17895	COG1595	DNA-templated transcription, initiation
CP974_RS17905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP974_RS17910	COG0436	Aminotransferase
CP974_RS17930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP974_RS17935	COG0081	regulation of translation
CP974_RS17950	COG0222	ribosome binding
CP974_RS17960	COG0085	RNA polymerase activity
CP974_RS17965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP974_RS18080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP974_RS18085	COG0049	tRNA binding
CP974_RS18090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP974_RS18095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP974_RS18125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP974_RS18205	COG0051	transcription antitermination factor activity, RNA binding
CP974_RS18210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP974_RS18215	COG0088	Forms part of the polypeptide exit tunnel
CP974_RS18220	COG0089	rRNA binding
CP974_RS18225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP974_RS18230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP974_RS18235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP974_RS18240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP974_RS18245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP974_RS18250	COG0255	Belongs to the universal ribosomal protein uL29 family
CP974_RS18255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP974_RS18260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP974_RS18265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP974_RS18270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP974_RS18275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP974_RS18285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP974_RS18290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP974_RS18295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP974_RS18300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP974_RS18305	COG1841	ribosomal large subunit assembly
CP974_RS18310	COG0200	Binds to the 23S rRNA
CP974_RS18315	COG0201	protein transport
CP974_RS18320	COG0563	adenylate kinase activity
CP974_RS18335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP974_RS18340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP974_RS18345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP974_RS18350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP974_RS18355	COG0202	RNA polymerase activity
CP974_RS18360	COG0203	ribosomal protein L17
CP974_RS18365	COG0101	tRNA pseudouridine synthase activity
CP974_RS18380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP974_RS18385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP974_RS18390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP974_RS18405	COG2161	toxin-antitoxin pair type II binding
CP974_RS18410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP974_RS18415	COG0736	holo-[acyl-carrier-protein] synthase activity
CP974_RS18425	COG0596	Alpha beta hydrolase
CP974_RS18485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP974_RS18500	COG0802	atpase or kinase
CP974_RS18525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP974_RS18545	COG0726	polysaccharide deacetylase
CP974_RS18550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP974_RS18565	COG0583	DNA-binding transcription factor activity
CP974_RS18570	COG4221	oxidoreductase activity
CP974_RS18580	COG0583	DNA-binding transcription factor activity
CP974_RS18590	COG2197	response regulator
CP974_RS18595	COG1595	DNA-templated transcription, initiation
CP974_RS18605	COG0516	GMP reductase activity
CP974_RS18620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP974_RS18635	COG0515	serine threonine protein kinase
CP974_RS18645	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS18700	COG0519	Catalyzes the synthesis of GMP from XMP
CP974_RS18700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP974_RS18720	COG2197	response regulator
CP974_RS18765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS18765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS18785	COG0714	Associated with various cellular activities
CP974_RS18795	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP974_RS18805	COG0045	succinate-CoA ligase (ADP-forming) activity
CP974_RS18820	COG1136	(ABC) transporter
CP974_RS18825	COG4585	Histidine kinase
CP974_RS18830	COG2197	response regulator
CP974_RS18875	COG0138	bifunctional purine biosynthesis protein purh
CP974_RS18910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP974_RS18925	COG0039	L-malate dehydrogenase activity
CP974_RS18930	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS18940	COG0517	IMP dehydrogenase activity
CP974_RS18940	COG4175	Glycine betaine
CP974_RS18945	COG4176	ABC-type proline glycine betaine transport system permease component
CP974_RS18960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP974_RS18965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP974_RS18975	COG0754	glutathionylspermidine amidase activity
CP974_RS18980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP974_RS18985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP974_RS18990	COG0180	Tryptophanyl-tRNA synthetase
CP974_RS19000	COG1295	ribonuclease BN
CP974_RS19005	COG1686	Belongs to the peptidase S11 family
CP974_RS19015	COG1408	metallophosphoesterase
CP974_RS19020	COG4166	transmembrane transport
CP974_RS19035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP974_RS19040	COG1053	succinate dehydrogenase
CP974_RS19050	COG2009	succinate dehydrogenase
CP974_RS19060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP974_RS19080	COG1834	amidinotransferase
CP974_RS19095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP974_RS19100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP974_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS19120	COG0546	phosphoglycolate phosphatase activity
CP974_RS19135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP974_RS19160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP974_RS19175	COG1595	DNA-templated transcription, initiation
CP974_RS19190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS19190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS19210	COG1216	Glycosyl transferase, family 2
CP974_RS19220	COG1083	cytidylyl-transferase
CP974_RS19225	COG2089	acid synthase
CP974_RS19235	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP974_RS19235	COG1473	amidohydrolase
CP974_RS19240	COG1396	sequence-specific DNA binding
CP974_RS19245	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CP974_RS19250	COG1744	ABC transporter substrate-binding protein PnrA-like
CP974_RS19255	COG3845	ABC transporter
CP974_RS19265	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP974_RS19295	COG2814	Major facilitator Superfamily
CP974_RS19300	COG0583	DNA-binding transcription factor activity
CP974_RS19310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP974_RS19335	COG2205	protein histidine kinase activity
CP974_RS19340	COG0745	RESPONSE REGULATOR receiver
CP974_RS19345	COG1595	DNA-templated transcription, initiation
CP974_RS19360	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS19365	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS19370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CP974_RS19375	COG3973	AAA domain
CP974_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS19460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP974_RS19510	COG4770	biotin carboxylase activity
CP974_RS19520	COG0424	maF-like protein
CP974_RS19530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP974_RS19545	COG1024	Enoyl-CoA hydratase
CP974_RS19565	COG2986	histidine ammonia-lyase
CP974_RS19580	COG1376	ErfK ybiS ycfS ynhG family protein
CP974_RS19595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP974_RS19610	COG0501	Belongs to the peptidase M48B family
CP974_RS19640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP974_RS19655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP974_RS19665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP974_RS19685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP974_RS19695	COG1331	Highly conserved protein containing a thioredoxin domain
CP974_RS19715	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CP974_RS19735	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP974_RS19755	COG1414	Transcriptional regulator
CP974_RS19835	COG2885	chlorophyll binding
CP974_RS19860	COG0667	Aldo Keto reductase
CP974_RS19865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP974_RS19870	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CP974_RS19890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP974_RS19895	COG0450	alkyl hydroperoxide reductase
CP974_RS19920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP974_RS19935	COG0114	fumarate hydratase activity
CP974_RS19945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CP974_RS19945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CP974_RS19975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP974_RS19980	COG1570	exodeoxyribonuclease VII activity
CP974_RS19985	COG1722	exodeoxyribonuclease VII activity
CP974_RS19990	COG0778	Nitroreductase
CP974_RS20000	COG0012	GTP binding
CP974_RS20135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP974_RS20180	COG1217	gtp-binding protein TYPA
CP974_RS20185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP974_RS20190	COG4166	transmembrane transport
CP974_RS20195	COG0601	transmembrane transport
CP974_RS20200	COG0444	Belongs to the ABC transporter superfamily
CP974_RS20205	COG4608	Belongs to the ABC transporter superfamily
CP974_RS20210	COG4166	transmembrane transport
CP974_RS20215	COG0601	transmembrane transport
CP974_RS20220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP974_RS20225	COG0444	Belongs to the ABC transporter superfamily
CP974_RS20230	COG4608	Belongs to the ABC transporter superfamily
CP974_RS20245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP974_RS20295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP974_RS20300	COG1611	Belongs to the LOG family
CP974_RS20305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP974_RS20315	COG0519	Catalyzes the synthesis of GMP from XMP
CP974_RS20320	COG1024	Enoyl-CoA hydratase
CP974_RS20335	COG1595	DNA-templated transcription, initiation
CP974_RS20345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP974_RS20350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP974_RS20385	COG0598	Magnesium transport protein CorA
CP974_RS20410	COG2095	MarC family integral membrane protein
CP974_RS20415	COG1432	Conserved Protein
CP974_RS20455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP974_RS20455	COG0596	Alpha beta hydrolase
CP974_RS20535	COG0210	DNA helicase
CP974_RS20540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP974_RS20575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP974_RS20650	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP974_RS20660	COG1615	UPF0182 protein
CP974_RS20685	COG0753	catalase activity
CP974_RS20690	COG0483	inositol monophosphate 1-phosphatase activity
CP974_RS20695	COG2076	Multidrug Resistance protein
CP974_RS20705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP974_RS20715	COG2135	peptidase activity
CP974_RS20725	COG1595	DNA-templated transcription, initiation
CP974_RS20730	COG5662	AntiSigma factor
CP974_RS20735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CP974_RS20735	COG2199	diguanylate cyclase activity
CP974_RS20750	COG0242	peptide deformylase activity
CP974_RS20760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP974_RS20780	COG2337	Toxic component of a toxin-antitoxin (TA) module
CP974_RS20800	COG2188	Transcriptional regulator
CP974_RS20805	COG2182	Extracellular solute-binding protein
CP974_RS20810	COG1175	transmembrane transport
CP974_RS20815	COG0395	ABC-type sugar transport system, permease component
CP974_RS20820	COG1472	Belongs to the glycosyl hydrolase 3 family
CP974_RS20825	COG0363	glucosamine-6-phosphate deaminase activity
CP974_RS20840	COG1597	lipid kinase activity
CP974_RS20860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CP974_RS20865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP974_RS20870	COG0142	geranyltranstransferase activity
CP974_RS20885	COG5640	endopeptidase activity
CP974_RS20920	COG1136	(ABC) transporter
CP974_RS20945	COG1126	abc transporter atp-binding protein
CP974_RS20990	COG0604	alcohol dehydrogenase
CP974_RS21020	COG0567	Dehydrogenase, E1 component
CP974_RS21020	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP974_RS21025	COG2205	protein histidine kinase activity
CP974_RS21030	COG0745	RESPONSE REGULATOR receiver
CP974_RS21050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP974_RS21060	COG3227	Zinc metalloprotease (Elastase)
CP974_RS21065	COG2197	response regulator
CP974_RS21070	COG4585	Histidine kinase
CP974_RS21125	COG2197	response regulator
CP974_RS21140	COG1136	(ABC) transporter
CP974_RS21145	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CP974_RS21165	COG0768	penicillin binding
CP974_RS21175	COG2205	protein histidine kinase activity
CP974_RS21195	COG1793	dna ligase
CP974_RS21200	COG3285	dna ligase
CP974_RS21200	COG1793	dna ligase
CP974_RS21205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP974_RS21225	COG0515	serine threonine protein kinase
CP974_RS21240	COG1653	transport
CP974_RS21255	COG1192	Involved in chromosome partitioning
CP974_RS21270	COG0745	RESPONSE REGULATOR receiver
CP974_RS21275	COG0018	arginyl-trna synthetase
CP974_RS21280	COG0019	diaminopimelate decarboxylase activity
CP974_RS21285	COG0460	homoserine dehydrogenase
CP974_RS21290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP974_RS21295	COG0083	homoserine kinase activity
CP974_RS21310	COG1316	TRANSCRIPTIONal
CP974_RS21315	COG0254	rRNA binding
CP974_RS21320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP974_RS21325	COG2890	protein-(glutamine-N5) methyltransferase activity
CP974_RS21335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP974_RS21340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP974_RS21360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP974_RS21365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP974_RS21370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP974_RS21375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP974_RS21380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP974_RS21385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP974_RS21390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP974_RS21405	COG2197	response regulator
CP974_RS21410	COG4585	Histidine kinase
CP974_RS21425	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP974_RS21440	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CP974_RS21475	COG1131	(ABC) transporter
CP974_RS21495	COG0183	Belongs to the thiolase family
CP974_RS21560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS21560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS21605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CP974_RS21610	COG0857	belongs to the CobB CobQ family
CP974_RS21610	COG0280	phosphate acetyltransferase
CP974_RS21620	COG0205	6-phosphofructokinase activity
CP974_RS21635	COG4565	transcriptional regulatory protein
CP974_RS21640	COG3290	protein histidine kinase activity
CP974_RS21645	COG1301	dicarboxylic acid transport
CP974_RS21660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP974_RS21665	COG3281	Trehalose synthase
CP974_RS21675	COG0366	Alpha amylase catalytic
CP974_RS21680	COG0058	SHG alpha-glucan phosphorylase activity
CP974_RS21695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP974_RS21705	COG1132	(ABC) transporter
CP974_RS21720	COG1376	ErfK ybiS ycfS ynhG family protein
CP974_RS21750	COG2197	response regulator
CP974_RS21775	COG1760	l-serine dehydratase
CP974_RS21780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP974_RS21785	COG0509	glycine decarboxylation via glycine cleavage system
CP974_RS21790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP974_RS21810	COG0747	negative chemotaxis
CP974_RS21815	COG0601	transmembrane transport
CP974_RS21820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP974_RS21825	COG0444	Belongs to the ABC transporter superfamily
CP974_RS21830	COG4608	Belongs to the ABC transporter superfamily
CP974_RS21835	COG2860	membrane
CP974_RS21870	COG0482	sulfurtransferase activity
CP974_RS21880	COG4221	oxidoreductase activity
CP974_RS21890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP974_RS21900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP974_RS21905	COG0154	amidase activity
CP974_RS21915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP974_RS21920	COG2409	Drug exporters of the RND superfamily
CP974_RS21925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP974_RS21930	COG2133	pyrroloquinoline quinone binding
CP974_RS21935	COG0667	Aldo Keto reductase
CP974_RS21955	COG0440	acetolactate synthase activity
CP974_RS21960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP974_RS21970	COG3835	regulator
CP974_RS21975	COG0506	proline dehydrogenase activity
CP974_RS21980	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS21995	COG0473	3-isopropylmalate dehydrogenase activity
CP974_RS22000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP974_RS22005	COG0832	Belongs to the urease beta subunit family
CP974_RS22005	COG0831	urea catabolic process
CP974_RS22010	COG0804	urea catabolic process
CP974_RS22015	COG2957	Belongs to the agmatine deiminase family
CP974_RS22030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP974_RS22050	COG2353	YceI-like domain
CP974_RS22055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP974_RS22075	COG2018	Roadblock/LC7 domain
CP974_RS22095	COG2018	Roadblock/LC7 domain
CP974_RS22110	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP974_RS22115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP974_RS22120	COG1011	Hydrolase
CP974_RS22150	COG1414	Transcriptional regulator
CP974_RS22155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP974_RS22160	COG0066	3-isopropylmalate dehydratase activity
CP974_RS22170	COG0776	regulation of translation
CP974_RS22180	COG1920	GTP binding
CP974_RS22190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP974_RS22195	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP974_RS22215	COG0351	phosphomethylpyrimidine kinase
CP974_RS22220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP974_RS22225	COG1461	Dihydroxyacetone kinase
CP974_RS22235	COG0742	ribosomal rna small subunit methyltransferase
CP974_RS22240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP974_RS22255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP974_RS22260	COG0571	ribonuclease III activity
CP974_RS22265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP974_RS22270	COG2340	Cysteine-rich secretory protein family
CP974_RS22275	COG1254	Belongs to the acylphosphatase family
CP974_RS22290	COG0477	Major facilitator Superfamily
CP974_RS22320	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP974_RS22340	COG0228	four-way junction DNA binding
CP974_RS22345	COG1837	Belongs to the UPF0109 family
CP974_RS22350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP974_RS22355	COG0336	Belongs to the RNA methyltransferase TrmD family
CP974_RS22360	COG0335	large ribosomal subunit rRNA binding
CP974_RS22365	COG0681	Belongs to the peptidase S26 family
CP974_RS22370	COG0681	Belongs to the peptidase S26 family
CP974_RS22380	COG0681	Belongs to the peptidase S26 family
CP974_RS22385	COG1051	belongs to the nudix hydrolase family
CP974_RS22395	COG0792	nuclease activity
CP974_RS22410	COG1191	sigma factor activity
CP974_RS22425	COG0052	Belongs to the universal ribosomal protein uS2 family
CP974_RS22430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP974_RS22435	COG0528	UMP kinase activity
CP974_RS22440	COG0233	cytoplasmic translational termination
CP974_RS22450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP974_RS22460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CP974_RS22465	COG3842	ATPase activity
CP974_RS22470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CP974_RS22485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP974_RS22495	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS22500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP974_RS22515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP974_RS22540	COG3842	ATPase activity
CP974_RS22545	COG1176	ABC-type spermidine putrescine transport system, permease component I
CP974_RS22550	COG1177	transmembrane transport
CP974_RS22555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP974_RS22585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS22590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP974_RS22595	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS22605	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP974_RS22620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP974_RS22655	COG2508	Transcriptional regulator
CP974_RS22660	COG0697	spore germination
CP974_RS22665	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS22675	COG0039	L-malate dehydrogenase activity
CP974_RS22690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP974_RS22695	COG0750	zinc metalloprotease
CP974_RS22700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP974_RS22715	COG0442	prolyl-tRNA aminoacylation
CP974_RS22720	COG0330	HflC and HflK could
CP974_RS22740	COG0779	Required for maturation of 30S ribosomal subunits
CP974_RS22755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP974_RS22765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP974_RS22770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP974_RS22790	COG0455	bacterial-type flagellum organization
CP974_RS22810	COG3266	domain, Protein
CP974_RS22815	COG1404	Belongs to the peptidase S8 family
CP974_RS22845	COG1674	ftsk spoiiie
CP974_RS22855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP974_RS22860	COG1185	polyribonucleotide nucleotidyltransferase activity
CP974_RS22865	COG0612	Peptidase, M16
CP974_RS22870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP974_RS22890	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CP974_RS22895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP974_RS22900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP974_RS22925	COG2770	Histidine kinase
CP974_RS22925	COG2208	phosphoserine phosphatase activity
CP974_RS22930	COG4999	Histidine kinase
CP974_RS22930	COG2205	protein histidine kinase activity
CP974_RS22930	COG3850	Histidine kinase
CP974_RS22930	COG3437	response regulator, receiver
CP974_RS22940	COG1674	ftsk spoiiie
CP974_RS22950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP974_RS22960	COG1058	Belongs to the CinA family
CP974_RS22960	COG1546	Belongs to the CinA family
CP974_RS22965	COG1396	sequence-specific DNA binding
CP974_RS22970	COG0783	Belongs to the Dps family
CP974_RS22980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP974_RS22990	COG1201	RNA secondary structure unwinding
CP974_RS22995	COG2207	Transcriptional regulator
CP974_RS22995	COG1917	Cupin 2, conserved barrel domain protein
CP974_RS23030	COG1271	oxidase subunit
CP974_RS23035	COG2197	response regulator
CP974_RS23040	COG4585	Histidine kinase
CP974_RS23055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP974_RS23060	COG0765	amino acid transport
CP974_RS23065	COG0765	amino acid transport
CP974_RS23070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP974_RS23075	COG1126	abc transporter atp-binding protein
CP974_RS23080	COG0745	RESPONSE REGULATOR receiver
CP974_RS23085	COG2205	protein histidine kinase activity
CP974_RS23095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP974_RS23115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP974_RS23125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP974_RS23130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP974_RS23140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP974_RS23155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP974_RS23160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP974_RS23165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP974_RS23185	COG0488	(ABC) transporter
CP974_RS23195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP974_RS23220	COG0477	Major facilitator Superfamily
CP974_RS23250	COG2186	Transcriptional regulator
CP974_RS23255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP974_RS23280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP974_RS23285	COG0612	Peptidase, M16
CP974_RS23295	COG0739	heme binding
CP974_RS23300	COG1802	Transcriptional regulator
CP974_RS23305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP974_RS23310	COG0045	succinate-CoA ligase (ADP-forming) activity
CP974_RS23310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP974_RS23310	COG1042	CoA-binding domain protein
CP974_RS23360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP974_RS23370	COG3415	Transposase
CP974_RS23370	COG2801	Transposase and inactivated derivatives
CP974_RS23380	COG0745	RESPONSE REGULATOR receiver
CP974_RS23385	COG2205	protein histidine kinase activity
CP974_RS23410	COG0756	dUTP diphosphatase activity
CP974_RS23445	COG0569	domain protein
CP974_RS23450	COG0531	amino acid
CP974_RS23455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP974_RS23515	COG1278	Cold shock
CP974_RS23520	COG0513	Belongs to the DEAD box helicase family
CP974_RS23630	COG2124	cytochrome p450
CP974_RS23635	COG2124	cytochrome p450
CP974_RS23695	COG0110	maltose O-acetyltransferase activity
CP974_RS23700	COG2409	Drug exporters of the RND superfamily
CP974_RS23740	COG1309	transcriptional regulator
CP974_RS23750	COG2070	2-Nitropropane dioxygenase
CP974_RS23785	COG1175	transmembrane transport
CP974_RS23790	COG0395	ABC-type sugar transport system, permease component
CP974_RS23810	COG2255	four-way junction helicase activity
CP974_RS23815	COG2824	Alkylphosphonate utilization operon protein PhnA
CP974_RS23825	COG0659	secondary active sulfate transmembrane transporter activity
CP974_RS23835	COG0644	oxidoreductase
CP974_RS23850	COG4221	oxidoreductase activity
CP974_RS23850	COG3321	synthase
CP974_RS23850	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS23850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS23860	COG4335	DNA alkylation repair
CP974_RS23890	COG0477	Major facilitator Superfamily
CP974_RS23905	COG1309	transcriptional regulator
CP974_RS23920	COG2319	Wd-40 repeat
CP974_RS23920	COG4249	Peptidase C14 caspase catalytic subunit p20
CP974_RS23965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP974_RS23970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP974_RS23990	COG2226	methyltransferase
CP974_RS24030	COG1201	RNA secondary structure unwinding
CP974_RS24035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP974_RS24040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP974_RS24045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP974_RS24050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP974_RS24065	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP974_RS24070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP974_RS24080	COG3321	synthase
CP974_RS24080	COG0604	alcohol dehydrogenase
CP974_RS24100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP974_RS24110	COG1937	Protein conserved in bacteria
CP974_RS24120	COG1309	transcriptional regulator
CP974_RS24150	COG3903	Transcriptional regulator
CP974_RS24150	COG3629	intracellular signal transduction
CP974_RS24200	COG0523	cobalamin synthesis protein
CP974_RS24210	COG2268	Band 7 protein
CP974_RS24220	COG0142	geranyltranstransferase activity
CP974_RS24230	COG2124	cytochrome p450
CP974_RS24235	COG2124	cytochrome p450
CP974_RS24240	COG0542	response to heat
CP974_RS24340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP974_RS24350	COG1404	Belongs to the peptidase S8 family
CP974_RS24365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP974_RS24385	COG0107	imidazoleglycerol-phosphate synthase activity
CP974_RS24395	COG2197	response regulator
CP974_RS24400	COG1522	sequence-specific DNA binding
CP974_RS24405	COG1834	amidinotransferase
CP974_RS24410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP974_RS24425	COG2197	response regulator
CP974_RS24430	COG0596	Alpha beta hydrolase
CP974_RS24535	COG1864	DNA RNA non-specific endonuclease
CP974_RS24535	COG3591	Belongs to the peptidase S1B family
CP974_RS24565	COG1799	cell septum assembly
CP974_RS24605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP974_RS24660	COG2235	arginine
CP974_RS24665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP974_RS24700	COG2072	flavoprotein involved in K transport
CP974_RS24705	COG0798	PFAM Bile acid sodium symporter
CP974_RS24715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP974_RS24735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP974_RS24740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP974_RS24745	COG1653	transport
CP974_RS24750	COG1175	transmembrane transport
CP974_RS24755	COG0395	ABC-type sugar transport system, permease component
CP974_RS24760	COG1940	carbohydrate kinase activity
CP974_RS24765	COG4213	ABC transporter substrate-binding protein
CP974_RS24775	COG4214	carbohydrate transport
CP974_RS24785	COG0531	amino acid
CP974_RS24795	COG0514	ATP-dependent DNA helicase (RecQ)
CP974_RS24800	COG1024	Enoyl-CoA hydratase
CP974_RS24800	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP974_RS24805	COG0183	Belongs to the thiolase family
CP974_RS24820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP974_RS24835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP974_RS24850	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP974_RS24860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP974_RS24865	COG3253	May function as heme-dependent peroxidase
CP974_RS24870	COG3220	belongs to the UPF0276 family
CP974_RS24935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP974_RS24940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP974_RS24965	COG1716	ATPase activity
CP974_RS25005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP974_RS25035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP974_RS25050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP974_RS25080	COG0529	Catalyzes the synthesis of activated sulfate
CP974_RS25085	COG0175	sulfate reduction
CP974_RS25105	COG0456	acetyltransferase
CP974_RS25120	COG1960	acyl-CoA dehydrogenase activity
CP974_RS25140	COG0475	glutathione-regulated potassium exporter activity
CP974_RS25150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP974_RS25155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP974_RS25160	COG0019	diaminopimelate decarboxylase activity
CP974_RS25165	COG1162	GTPase activity
CP974_RS25170	COG1136	(ABC) transporter
CP974_RS25170	COG0577	efflux transmembrane transporter activity
CP974_RS25185	COG1136	(ABC) transporter
CP974_RS25210	COG0028	Belongs to the TPP enzyme family
CP974_RS25255	COG0778	Nitroreductase
CP974_RS25260	COG0135	phosphoribosylanthranilate isomerase activity
CP974_RS25265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP974_RS25270	COG0697	spore germination
CP974_RS25285	COG2313	pseudouridylate synthase activity
CP974_RS25290	COG1902	pentaerythritol trinitrate reductase activity
CP974_RS25295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP974_RS25315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP974_RS25320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP974_RS25350	COG1132	(ABC) transporter
CP974_RS25355	COG1132	(ABC) transporter
CP974_RS25365	COG3608	succinylglutamate desuccinylase aspartoacylase
CP974_RS25365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CP974_RS25375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP974_RS25380	COG3237	CsbD-like
CP974_RS25390	COG2080	2 iron, 2 sulfur cluster binding
CP974_RS25395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP974_RS25400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP974_RS25405	COG2066	Belongs to the glutaminase family
CP974_RS25410	COG2409	Drug exporters of the RND superfamily
CP974_RS25415	COG1846	Transcriptional regulator
CP974_RS25420	COG0702	epimerase
CP974_RS25435	COG1120	ATPase activity
CP974_RS25525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP974_RS25525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP974_RS25535	COG2197	response regulator
CP974_RS25540	COG3851	Histidine kinase
CP974_RS25560	COG0531	amino acid
CP974_RS25565	COG0586	Pfam SNARE associated Golgi protein
CP974_RS25585	COG2181	nitrate reductase activity
CP974_RS25595	COG1140	nitrate reductase beta subunit
CP974_RS25615	COG0490	domain, Protein
CP974_RS25615	COG2985	domain, Protein
CP974_RS25620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP974_RS25635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CP974_RS25635	COG0517	IMP dehydrogenase activity
CP974_RS25635	COG0617	tRNA 3'-terminal CCA addition
CP974_RS25640	COG0589	response to stress
CP974_RS25655	COG1140	nitrate reductase beta subunit
CP974_RS25675	COG0477	Major facilitator Superfamily
CP974_RS25700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CP974_RS25710	COG3118	belongs to the thioredoxin family
CP974_RS25720	COG0492	ferredoxin-NADP+ reductase activity
CP974_RS25730	COG2197	response regulator
CP974_RS25735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP974_RS25740	COG0318	PFAM AMP-dependent synthetase and ligase
CP974_RS25795	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
CP974_RS25800	COG2197	response regulator
CP974_RS25820	COG1136	(ABC) transporter
CP974_RS25825	COG1414	Transcriptional regulator
CP974_RS25840	COG4585	Histidine kinase
CP974_RS25845	COG2197	response regulator
CP974_RS25865	COG4214	carbohydrate transport
CP974_RS25870	COG1129	ABC transporter
CP974_RS25875	COG1940	carbohydrate kinase activity
CP974_RS25885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS25905	COG0475	glutathione-regulated potassium exporter activity
CP974_RS25930	COG1960	acyl-CoA dehydrogenase activity
CP974_RS25940	COG0300	oxidoreductase activity
CP974_RS25955	COG3903	Transcriptional regulator
CP974_RS25955	COG3629	intracellular signal transduction
CP974_RS25960	COG0477	Major facilitator Superfamily
CP974_RS25965	COG0583	DNA-binding transcription factor activity
CP974_RS25970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP974_RS26010	COG0405	Gamma-glutamyltransferase
CP974_RS26020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP974_RS26025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP974_RS26035	COG0659	secondary active sulfate transmembrane transporter activity
CP974_RS26050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP974_RS26075	COG0483	inositol monophosphate 1-phosphatase activity
CP974_RS26085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CP974_RS26090	COG2249	NAD(P)H dehydrogenase (quinone) activity
CP974_RS26095	COG0640	Transcriptional regulator
CP974_RS26100	COG2072	flavoprotein involved in K transport
CP974_RS26105	COG1556	Lactate utilization protein
CP974_RS26110	COG1139	Iron-sulfur cluster binding protein
CP974_RS26115	COG0247	lactate metabolic process
CP974_RS26135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP974_RS26140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP974_RS26160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP974_RS26165	COG1929	Belongs to the glycerate kinase type-1 family
CP974_RS26180	COG0688	phosphatidylethanolamine metabolic process
CP974_RS26185	COG1960	acyl-CoA dehydrogenase activity
CP974_RS26195	COG2301	Belongs to the HpcH HpaI aldolase family
CP974_RS26200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS26200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP974_RS26215	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP974_RS26230	COG0251	oxidation-reduction process
CP974_RS26265	COG1522	sequence-specific DNA binding
CP974_RS26270	COG2362	D-Aminopeptidase
CP974_RS26275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP974_RS26285	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP974_RS26290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP974_RS26300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP974_RS26325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP974_RS26340	COG0693	protein deglycase activity
CP974_RS26355	COG1191	sigma factor activity
CP974_RS26400	COG0531	amino acid
CP974_RS26405	COG0583	DNA-binding transcription factor activity
CP974_RS26410	COG0156	8-amino-7-oxononanoate synthase activity
CP974_RS26415	COG1063	alcohol dehydrogenase
CP974_RS26430	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP974_RS26440	COG4977	sequence-specific DNA binding
CP974_RS26450	COG2304	oxidoreductase activity
CP974_RS26480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP974_RS26485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS26560	COG2040	homocysteine
CP974_RS26590	COG1486	melibiose metabolic process
CP974_RS26600	COG3012	SEC-C Motif Domain Protein
CP974_RS26615	COG1793	dna ligase
CP974_RS26640	COG0488	(ABC) transporter
CP974_RS26650	COG1515	deoxyribonuclease V activity
CP974_RS26655	COG3268	Saccharopine dehydrogenase
CP974_RS26660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP974_RS26665	COG1960	acyl-CoA dehydrogenase activity
CP974_RS26670	COG0183	Belongs to the thiolase family
CP974_RS26675	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP974_RS26675	COG1024	Enoyl-CoA hydratase
CP974_RS26710	COG3415	Transposase
CP974_RS26710	COG2801	Transposase and inactivated derivatives
CP974_RS26730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP974_RS26735	COG0488	(ABC) transporter
CP974_RS26750	COG2183	response to ionizing radiation
CP974_RS26760	COG1024	Enoyl-CoA hydratase
CP974_RS26775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP974_RS26820	COG1134	teichoic acid transport
CP974_RS26825	COG1562	ergosterol biosynthetic process
CP974_RS26835	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP974_RS26845	COG1657	PFAM Prenyltransferase squalene oxidase
CP974_RS26870	COG2365	Tyrosine phosphatase family
CP974_RS26880	COG2755	lipolytic protein G-D-S-L family
CP974_RS26890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CP974_RS26895	COG0569	domain protein
CP974_RS26905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CP974_RS26910	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CP974_RS26915	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CP974_RS26945	COG1863	multisubunit Na H antiporter MnhE subunit
CP974_RS26950	COG0651	ATP synthesis coupled electron transport
CP974_RS26955	COG1006	Multisubunit Na H antiporter MnhC subunit
CP974_RS26960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP974_RS26960	COG2111	Na H antiporter
CP974_RS26980	COG0783	Belongs to the Dps family
CP974_RS27000	COG1595	DNA-templated transcription, initiation
CP974_RS27025	COG2226	methyltransferase
CP974_RS27030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP974_RS27030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CP974_RS27050	COG0142	geranyltranstransferase activity
CP974_RS27090	COG1960	acyl-CoA dehydrogenase activity
CP974_RS27115	COG1881	PFAM PEBP family protein
CP974_RS27135	COG0501	Belongs to the peptidase M48B family
CP974_RS27145	COG0477	Major facilitator Superfamily
CP974_RS27165	COG0443	Heat shock 70 kDa protein
CP974_RS27185	COG3189	MarR family transcriptional regulator
CP974_RS27240	COG0406	alpha-ribazole phosphatase activity
CP974_RS27255	COG1132	(ABC) transporter
CP974_RS27260	COG1132	(ABC) transporter
CP974_RS27315	COG3903	Transcriptional regulator
CP974_RS27315	COG3629	intracellular signal transduction
CP974_RS27335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP974_RS27340	COG1032	radical SAM domain protein
CP974_RS27400	COG1063	alcohol dehydrogenase
CP974_RS27415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP974_RS27425	COG0477	Major facilitator Superfamily
CP974_RS27445	COG3383	formate dehydrogenase (NAD+) activity
CP974_RS27455	COG1063	alcohol dehydrogenase
CP974_RS27465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP974_RS27465	COG1042	CoA-binding domain protein
CP974_RS27465	COG0045	succinate-CoA ligase (ADP-forming) activity
CP974_RS27490	COG0589	response to stress
CP974_RS27505	COG0517	IMP dehydrogenase activity
CP974_RS27505	COG0516	GMP reductase activity
CP974_RS27520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP974_RS27525	COG1120	ATPase activity
CP974_RS27575	COG1874	Beta-galactosidase
CP974_RS27575	COG0366	Alpha amylase catalytic
CP974_RS27630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP974_RS27680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP974_RS27695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP974_RS27700	COG3275	phosphorelay sensor kinase activity
CP974_RS27705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP974_RS27770	COG2208	phosphoserine phosphatase activity
CP974_RS27770	COG2770	Histidine kinase
CP974_RS27790	COG0583	DNA-binding transcription factor activity
CP974_RS27800	COG1053	succinate dehydrogenase
CP974_RS27805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP974_RS27810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP974_RS27820	COG3360	Dodecin
CP974_RS27825	COG2182	Extracellular solute-binding protein
CP974_RS27840	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP974_RS27845	COG0121	glutamine amidotransferase
CP974_RS27850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP974_RS27870	COG0183	Belongs to the thiolase family
CP974_RS27875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP974_RS27885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP974_RS27900	COG1959	2 iron, 2 sulfur cluster binding
CP974_RS27900	COG1295	ribonuclease BN
CP974_RS27955	COG3708	Transcriptional regulator
CP974_RS27955	COG2207	Transcriptional regulator
CP974_RS27965	COG0367	asparagine synthase
CP974_RS27970	COG2814	Major facilitator Superfamily
CP974_RS28005	COG2124	cytochrome p450
CP974_RS28020	COG1357	PFAM Pentapeptide repeats (8 copies)
CP974_RS28055	COG3458	cephalosporin-C deacetylase activity
CP974_RS28080	COG1960	acyl-CoA dehydrogenase activity
CP974_RS28085	COG1960	acyl-CoA dehydrogenase activity
CP974_RS28095	COG0601	transmembrane transport
CP974_RS28100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP974_RS28125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP974_RS28195	COG0243	molybdopterin cofactor binding
CP974_RS28215	COG0659	secondary active sulfate transmembrane transporter activity
CP974_RS28295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS28325	COG2890	protein-(glutamine-N5) methyltransferase activity
CP974_RS28355	COG0189	ligase activity
CP974_RS28365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP974_RS28370	COG1396	sequence-specific DNA binding
CP974_RS28375	COG0235	Class ii aldolase
CP974_RS28380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP974_RS28395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP974_RS28410	COG3629	intracellular signal transduction
CP974_RS28545	COG2318	DinB family
CP974_RS28560	COG1028	Short-chain dehydrogenase reductase Sdr
CP974_RS28595	COG3415	Transposase
CP974_RS28595	COG2801	Transposase and inactivated derivatives
CP974_RS28600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP974_RS28605	COG1937	Protein conserved in bacteria
CP974_RS28655	COG0515	serine threonine protein kinase
CP974_RS28665	COG1733	regulation of RNA biosynthetic process
CP974_RS28695	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CP974_RS28720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP974_RS28725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP974_RS28730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP974_RS28800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP974_RS28805	COG0513	Belongs to the DEAD box helicase family
CP974_RS28810	COG1012	belongs to the aldehyde dehydrogenase family
CP974_RS28820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP974_RS28830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP974_RS28855	COG2018	Roadblock/LC7 domain
CP974_RS28870	COG1793	dna ligase
CP974_RS28935	COG2124	cytochrome p450
CP974_RS28940	COG3424	synthase
CP974_RS28950	COG0726	polysaccharide deacetylase
CP974_RS28990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP974_RS29005	COG1595	DNA-templated transcription, initiation
CP974_RS29015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP974_RS29030	COG3340	Belongs to the peptidase S51 family
CP974_RS29045	COG0656	L-ascorbic acid biosynthetic process
CP974_RS29050	COG2706	6-phosphogluconolactonase activity
CP974_RS29075	COG0009	L-threonylcarbamoyladenylate synthase
CP974_RS29125	COG1017	nitric oxide dioxygenase activity
CP974_RS29125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP974_RS29165	COG1309	transcriptional regulator
CP974_RS29185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS29205	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP974_RS29235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP974_RS29240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP974_RS29245	COG0066	3-isopropylmalate dehydratase activity
CP974_RS29250	COG0436	Aminotransferase
CP974_RS29260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP974_RS29275	COG2267	carboxylic ester hydrolase activity
CP974_RS29300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP974_RS29310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP974_RS29320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP974_RS29330	COG0655	NAD(P)H dehydrogenase (quinone) activity