locus-tag	class	description
D3X13_RS00110	COG1595	DNA-templated transcription, initiation
D3X13_RS00185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS00190	COG1309	transcriptional regulator
D3X13_RS00290	COG2175	clavaminate synthase activity
D3X13_RS00295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3X13_RS00350	COG2197	response regulator
D3X13_RS00360	COG3959	Transketolase, thiamine diphosphate binding domain
D3X13_RS00365	COG3958	Transketolase
D3X13_RS00375	COG3251	PFAM MbtH domain protein
D3X13_RS00400	COG0604	alcohol dehydrogenase
D3X13_RS00400	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS00400	COG3321	synthase
D3X13_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS00430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS00440	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS00470	COG3629	intracellular signal transduction
D3X13_RS00470	COG3903	Transcriptional regulator
D3X13_RS00475	COG2197	response regulator
D3X13_RS00490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3X13_RS00505	COG0667	Aldo Keto reductase
D3X13_RS00525	COG0076	glutamate decarboxylase activity
D3X13_RS00540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS00550	COG2070	2-Nitropropane dioxygenase
D3X13_RS00590	COG0702	epimerase
D3X13_RS00595	COG2124	cytochrome p450
D3X13_RS00665	COG0477	Major facilitator Superfamily
D3X13_RS00790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3X13_RS00800	COG4977	sequence-specific DNA binding
D3X13_RS00820	COG0596	Alpha beta hydrolase
D3X13_RS00825	COG1309	transcriptional regulator
D3X13_RS00850	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS00860	COG1309	transcriptional regulator
D3X13_RS00865	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS00890	COG2409	Drug exporters of the RND superfamily
D3X13_RS00920	COG0583	DNA-binding transcription factor activity
D3X13_RS00945	COG2326	polyphosphate kinase activity
D3X13_RS00950	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D3X13_RS00965	COG0596	Alpha beta hydrolase
D3X13_RS00995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3X13_RS01015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3X13_RS01020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3X13_RS01050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3X13_RS01070	COG0583	DNA-binding transcription factor activity
D3X13_RS01080	COG2080	2 iron, 2 sulfur cluster binding
D3X13_RS01085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3X13_RS01090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3X13_RS01095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D3X13_RS01095	COG1796	DNA polymerase
D3X13_RS01110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3X13_RS01120	COG2124	cytochrome p450
D3X13_RS01140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3X13_RS01150	COG0583	DNA-binding transcription factor activity
D3X13_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS01175	COG0300	oxidoreductase activity
D3X13_RS01175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS01175	COG3321	synthase
D3X13_RS01180	COG3321	synthase
D3X13_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS01180	COG4221	oxidoreductase activity
D3X13_RS01195	COG4221	oxidoreductase activity
D3X13_RS01195	COG3321	synthase
D3X13_RS01195	COG0300	oxidoreductase activity
D3X13_RS01195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS01205	COG3321	synthase
D3X13_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS01205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS01205	COG0300	oxidoreductase activity
D3X13_RS01205	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS01210	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS01225	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS01240	COG0477	Major facilitator Superfamily
D3X13_RS01245	COG1957	nucleoside hydrolase
D3X13_RS01275	COG0477	Major facilitator Superfamily
D3X13_RS01310	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D3X13_RS01315	COG2814	Major facilitator Superfamily
D3X13_RS01320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3X13_RS01335	COG1228	amidohydrolase
D3X13_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS01355	COG0512	Glutamine amidotransferase of anthranilate synthase
D3X13_RS01375	COG0477	Major facilitator Superfamily
D3X13_RS01395	COG0583	DNA-binding transcription factor activity
D3X13_RS01405	COG1595	DNA-templated transcription, initiation
D3X13_RS01430	COG1609	Transcriptional regulator
D3X13_RS01435	COG3250	beta-galactosidase activity
D3X13_RS01445	COG1175	transmembrane transport
D3X13_RS01450	COG3833	ABC-type maltose transport systems, permease component
D3X13_RS01525	COG0494	nUDIX hydrolase
D3X13_RS01560	COG0789	Transcriptional regulator
D3X13_RS01580	COG0778	Nitroreductase
D3X13_RS01600	COG1309	transcriptional regulator
D3X13_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS01660	COG0107	imidazoleglycerol-phosphate synthase activity
D3X13_RS01675	COG2197	response regulator
D3X13_RS01680	COG1129	ABC transporter
D3X13_RS01685	COG1120	ATPase activity
D3X13_RS01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS01705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3X13_RS01755	COG1404	Belongs to the peptidase S8 family
D3X13_RS01770	COG2271	Major facilitator Superfamily
D3X13_RS01790	COG2226	methyltransferase
D3X13_RS01800	COG1595	DNA-templated transcription, initiation
D3X13_RS01865	COG1819	glycosyl
D3X13_RS01870	COG0789	Transcriptional regulator
D3X13_RS01875	COG0823	Involved in the tonB-independent uptake of proteins
D3X13_RS01895	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3X13_RS01940	COG2124	cytochrome p450
D3X13_RS01950	COG3424	synthase
D3X13_RS02010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3X13_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS02055	COG1686	Belongs to the peptidase S11 family
D3X13_RS02065	COG1653	transport
D3X13_RS02095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3X13_RS02100	COG5640	endopeptidase activity
D3X13_RS02120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3X13_RS02150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3X13_RS02250	COG0582	viral genome integration into host DNA
D3X13_RS02260	COG1764	response to oxidative stress
D3X13_RS02265	COG1846	Transcriptional regulator
D3X13_RS02270	COG1535	isochorismatase
D3X13_RS02270	COG3433	isochorismatase activity
D3X13_RS02275	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3X13_RS02280	COG1169	isochorismate synthase
D3X13_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS02295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3X13_RS02315	COG1846	Transcriptional regulator
D3X13_RS02320	COG3384	dioxygenase
D3X13_RS02330	COG1247	-acetyltransferase
D3X13_RS02345	COG0477	Major facilitator Superfamily
D3X13_RS02360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS02365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3X13_RS02385	COG0366	Alpha amylase catalytic
D3X13_RS02390	COG3833	ABC-type maltose transport systems, permease component
D3X13_RS02395	COG1175	transmembrane transport
D3X13_RS02405	COG1609	Transcriptional regulator
D3X13_RS02425	COG1131	(ABC) transporter
D3X13_RS02450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3X13_RS02465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3X13_RS02470	COG0662	Cupin 2, conserved barrel domain protein
D3X13_RS02500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS02510	COG4989	oxidoreductase activity
D3X13_RS02520	COG2814	Major facilitator Superfamily
D3X13_RS02535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3X13_RS02625	COG1024	Enoyl-CoA hydratase
D3X13_RS02635	COG1605	Chorismate mutase
D3X13_RS02640	COG2267	carboxylic ester hydrolase activity
D3X13_RS02650	COG3033	Beta-eliminating lyase
D3X13_RS02685	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS02690	COG2366	antibiotic biosynthetic process
D3X13_RS02700	COG2070	2-Nitropropane dioxygenase
D3X13_RS02705	COG0789	Transcriptional regulator
D3X13_RS02715	COG2815	serine threonine protein kinase
D3X13_RS02715	COG0515	serine threonine protein kinase
D3X13_RS02725	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS02780	COG2267	carboxylic ester hydrolase activity
D3X13_RS02805	COG0456	acetyltransferase
D3X13_RS02820	COG4948	Mandelate Racemase Muconate Lactonizing
D3X13_RS02840	COG1064	alcohol dehydrogenase
D3X13_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS02870	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3X13_RS02875	COG1982	Orn Lys Arg decarboxylase major
D3X13_RS02905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3X13_RS02910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3X13_RS02930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3X13_RS02935	COG1609	Transcriptional regulator
D3X13_RS02950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3X13_RS02955	COG0121	glutamine amidotransferase
D3X13_RS02960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3X13_RS02965	COG2182	Extracellular solute-binding protein
D3X13_RS02975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS02980	COG0577	efflux transmembrane transporter activity
D3X13_RS02980	COG1136	(ABC) transporter
D3X13_RS02985	COG1136	(ABC) transporter
D3X13_RS02985	COG0577	efflux transmembrane transporter activity
D3X13_RS03005	COG2124	cytochrome p450
D3X13_RS03010	COG2124	cytochrome p450
D3X13_RS03015	COG2124	cytochrome p450
D3X13_RS03020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS03045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS03050	COG2205	protein histidine kinase activity
D3X13_RS03055	COG1132	(ABC) transporter
D3X13_RS03070	COG1024	Enoyl-CoA hydratase
D3X13_RS03075	COG1024	Enoyl-CoA hydratase
D3X13_RS03080	COG3424	synthase
D3X13_RS03110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3X13_RS03115	COG1053	succinate dehydrogenase
D3X13_RS03125	COG0583	DNA-binding transcription factor activity
D3X13_RS03190	COG0531	amino acid
D3X13_RS03205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3X13_RS03220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D3X13_RS03230	COG0745	RESPONSE REGULATOR receiver
D3X13_RS03265	COG0395	ABC-type sugar transport system, permease component
D3X13_RS03270	COG1175	transmembrane transport
D3X13_RS03305	COG3250	beta-galactosidase activity
D3X13_RS03310	COG1609	Transcriptional regulator
D3X13_RS03315	COG1879	ABC-type sugar transport system periplasmic component
D3X13_RS03320	COG1129	ABC transporter
D3X13_RS03325	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS03330	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS03335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3X13_RS03340	COG0297	glycogen (starch) synthase activity
D3X13_RS03360	COG3458	cephalosporin-C deacetylase activity
D3X13_RS03385	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3X13_RS03395	COG0463	Glycosyl transferase, family 2
D3X13_RS03395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D3X13_RS03400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3X13_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS03490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D3X13_RS03500	COG1063	alcohol dehydrogenase
D3X13_RS03525	COG1132	(ABC) transporter
D3X13_RS03575	COG2890	protein-(glutamine-N5) methyltransferase activity
D3X13_RS03605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS03610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3X13_RS03620	COG3655	Transcriptional regulator
D3X13_RS03625	COG2353	YceI-like domain
D3X13_RS03645	COG2197	response regulator
D3X13_RS03655	COG1222	aaa ATPase
D3X13_RS03760	COG1136	(ABC) transporter
D3X13_RS03775	COG2197	response regulator
D3X13_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS03815	COG1309	transcriptional regulator
D3X13_RS03855	COG0183	Belongs to the thiolase family
D3X13_RS03870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3X13_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS03900	COG0673	inositol 2-dehydrogenase activity
D3X13_RS03910	COG0395	ABC-type sugar transport system, permease component
D3X13_RS03915	COG1175	transmembrane transport
D3X13_RS03935	COG0668	transmembrane transport
D3X13_RS03960	COG3540	Alkaline phosphatase
D3X13_RS03990	COG2267	carboxylic ester hydrolase activity
D3X13_RS04010	COG1396	sequence-specific DNA binding
D3X13_RS04015	COG1116	anion transmembrane transporter activity
D3X13_RS04025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3X13_RS04030	COG0583	DNA-binding transcription factor activity
D3X13_RS04035	COG0156	8-amino-7-oxononanoate synthase activity
D3X13_RS04040	COG1063	alcohol dehydrogenase
D3X13_RS04045	COG0673	inositol 2-dehydrogenase activity
D3X13_RS04080	COG2755	lipolytic protein G-D-S-L family
D3X13_RS04090	COG2365	Tyrosine phosphatase family
D3X13_RS04115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3X13_RS04130	COG1657	PFAM Prenyltransferase squalene oxidase
D3X13_RS04140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D3X13_RS04150	COG1562	ergosterol biosynthetic process
D3X13_RS04155	COG1134	teichoic acid transport
D3X13_RS04205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D3X13_RS04215	COG1024	Enoyl-CoA hydratase
D3X13_RS04225	COG4977	sequence-specific DNA binding
D3X13_RS04240	COG2183	response to ionizing radiation
D3X13_RS04245	COG0488	(ABC) transporter
D3X13_RS04255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3X13_RS04265	COG2936	dipeptidyl-peptidase activity
D3X13_RS04275	COG1113	amino acid transport
D3X13_RS04290	COG1024	Enoyl-CoA hydratase
D3X13_RS04290	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS04295	COG0183	Belongs to the thiolase family
D3X13_RS04300	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS04305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3X13_RS04310	COG1683	Conserved Protein
D3X13_RS04315	COG3268	Saccharopine dehydrogenase
D3X13_RS04325	COG1515	deoxyribonuclease V activity
D3X13_RS04335	COG2268	Band 7 protein
D3X13_RS04360	COG0488	(ABC) transporter
D3X13_RS04365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3X13_RS04370	COG1834	amidinotransferase
D3X13_RS04460	COG1793	dna ligase
D3X13_RS04470	COG1470	cell adhesion involved in biofilm formation
D3X13_RS04475	COG1595	DNA-templated transcription, initiation
D3X13_RS04480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS04495	COG1024	Enoyl-CoA hydratase
D3X13_RS04520	COG0183	Belongs to the thiolase family
D3X13_RS04525	COG1309	transcriptional regulator
D3X13_RS04535	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS04540	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS04545	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3X13_RS04600	COG3511	phospholipase C
D3X13_RS04605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3X13_RS04620	COG1486	melibiose metabolic process
D3X13_RS04630	COG0477	Major facilitator Superfamily
D3X13_RS04640	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS04645	COG3246	L-lysine catabolic process to acetate
D3X13_RS04665	COG0577	efflux transmembrane transporter activity
D3X13_RS04665	COG1136	(ABC) transporter
D3X13_RS04740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3X13_RS04745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3X13_RS04755	COG0583	DNA-binding transcription factor activity
D3X13_RS04775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS04800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3X13_RS04825	COG1063	alcohol dehydrogenase
D3X13_RS04830	COG1472	Belongs to the glycosyl hydrolase 3 family
D3X13_RS04840	COG2223	nitrite transmembrane transporter activity
D3X13_RS04850	COG2207	Transcriptional regulator
D3X13_RS04855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS04865	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3X13_RS04875	COG3938	Belongs to the proline racemase family
D3X13_RS04920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3X13_RS04950	COG1879	ABC-type sugar transport system periplasmic component
D3X13_RS04955	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS04960	COG1129	ABC transporter
D3X13_RS04965	COG1940	carbohydrate kinase activity
D3X13_RS04980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS04985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3X13_RS05020	COG0656	L-ascorbic acid biosynthetic process
D3X13_RS05035	COG2226	methyltransferase
D3X13_RS05040	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3X13_RS05060	COG1140	nitrate reductase beta subunit
D3X13_RS05075	COG0443	Heat shock 70 kDa protein
D3X13_RS05085	COG0531	amino acid
D3X13_RS05135	COG0248	Ppx GppA phosphatase
D3X13_RS05150	COG0488	(ABC) transporter
D3X13_RS05160	COG2226	methyltransferase
D3X13_RS05215	COG3285	dna ligase
D3X13_RS05215	COG1793	dna ligase
D3X13_RS05250	COG0326	Molecular chaperone. Has ATPase activity
D3X13_RS05275	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3X13_RS05285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3X13_RS05290	COG2362	D-Aminopeptidase
D3X13_RS05300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3X13_RS05315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS05320	COG1120	ATPase activity
D3X13_RS05330	COG3386	PFAM SMP-30 Gluconolaconase
D3X13_RS05335	COG1414	Transcriptional regulator
D3X13_RS05365	COG4214	carbohydrate transport
D3X13_RS05395	COG1595	DNA-templated transcription, initiation
D3X13_RS05400	COG1501	Belongs to the glycosyl hydrolase 31 family
D3X13_RS05415	COG4209	transmembrane transport
D3X13_RS05420	COG0395	ABC-type sugar transport system, permease component
D3X13_RS05435	COG5297	Belongs to the glycosyl hydrolase family 6
D3X13_RS05450	COG3866	Pectate lyase
D3X13_RS05455	COG2755	lipolytic protein G-D-S-L family
D3X13_RS05460	COG1653	transport
D3X13_RS05480	COG0395	ABC-type sugar transport system, permease component
D3X13_RS05495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3X13_RS05500	COG1802	Transcriptional regulator
D3X13_RS05510	COG2208	phosphoserine phosphatase activity
D3X13_RS05510	COG2172	sigma factor antagonist activity
D3X13_RS05510	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS05545	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS05555	COG0604	alcohol dehydrogenase
D3X13_RS05560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3X13_RS05560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3X13_RS05565	COG2301	Belongs to the HpcH HpaI aldolase family
D3X13_RS05575	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS05580	COG0688	phosphatidylethanolamine metabolic process
D3X13_RS05595	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS05600	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS05620	COG1929	Belongs to the glycerate kinase type-1 family
D3X13_RS05630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3X13_RS05650	COG0483	inositol monophosphate 1-phosphatase activity
D3X13_RS05685	COG1140	nitrate reductase beta subunit
D3X13_RS05695	COG2181	nitrate reductase activity
D3X13_RS05710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3X13_RS05710	COG1017	nitric oxide dioxygenase activity
D3X13_RS05720	COG0702	epimerase
D3X13_RS05740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3X13_RS05745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3X13_RS05765	COG0405	Gamma-glutamyltransferase
D3X13_RS05825	COG3387	PFAM Glycoside hydrolase 15-related
D3X13_RS05855	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS05905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3X13_RS06100	COG0738	Major facilitator superfamily
D3X13_RS06105	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3X13_RS06240	COG0142	geranyltranstransferase activity
D3X13_RS06275	COG2175	clavaminate synthase activity
D3X13_RS06370	COG0243	molybdopterin cofactor binding
D3X13_RS06495	COG0159	tryptophan synthase activity
D3X13_RS06555	COG1857	crispr-associated protein
D3X13_RS06570	COG1518	maintenance of DNA repeat elements
D3X13_RS06575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3X13_RS06590	COG1376	ErfK ybiS ycfS ynhG family protein
D3X13_RS06600	COG0765	amino acid transport
D3X13_RS06605	COG0765	amino acid transport
D3X13_RS06610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3X13_RS06615	COG1126	abc transporter atp-binding protein
D3X13_RS06640	COG1131	(ABC) transporter
D3X13_RS06650	COG3851	Histidine kinase
D3X13_RS06675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS06690	COG1940	carbohydrate kinase activity
D3X13_RS06695	COG1129	ABC transporter
D3X13_RS06700	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS06715	COG2188	Transcriptional regulator
D3X13_RS06720	COG0673	inositol 2-dehydrogenase activity
D3X13_RS06730	COG2197	response regulator
D3X13_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS06755	COG4266	Belongs to the allantoicase family
D3X13_RS06760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3X13_RS06765	COG1414	Transcriptional regulator
D3X13_RS06770	COG1136	(ABC) transporter
D3X13_RS06775	COG0577	efflux transmembrane transporter activity
D3X13_RS06780	COG4585	Histidine kinase
D3X13_RS06795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3X13_RS06810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3X13_RS06825	COG0436	Aminotransferase
D3X13_RS06845	COG0588	phosphoglycerate mutase activity
D3X13_RS06860	COG2356	endonuclease I
D3X13_RS06890	COG0534	Mate efflux family protein
D3X13_RS06920	COG2233	PERMEase
D3X13_RS06930	COG2233	PERMEase
D3X13_RS06940	COG2351	hydroxyisourate hydrolase activity
D3X13_RS06965	COG3622	Belongs to the hyi family
D3X13_RS06970	COG2084	Dehydrogenase
D3X13_RS06975	COG0753	catalase activity
D3X13_RS06985	COG3960	tartronate-semialdehyde synthase activity
D3X13_RS07000	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS07005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3X13_RS07010	COG2197	response regulator
D3X13_RS07020	COG0598	Magnesium transport protein CorA
D3X13_RS07110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS07125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3X13_RS07175	COG2197	response regulator
D3X13_RS07195	COG0542	response to heat
D3X13_RS07200	COG0753	catalase activity
D3X13_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS07230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3X13_RS07235	COG4221	oxidoreductase activity
D3X13_RS07245	COG0859	PFAM glycosyl transferase family 9
D3X13_RS07250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3X13_RS07250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3X13_RS07255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3X13_RS07260	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS07270	COG0859	PFAM glycosyl transferase family 9
D3X13_RS07275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3X13_RS07285	COG2192	nodulation
D3X13_RS07290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3X13_RS07300	COG3594	Acyltransferase
D3X13_RS07305	COG0076	glutamate decarboxylase activity
D3X13_RS07350	COG2252	PERMEase
D3X13_RS07355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3X13_RS07375	COG3835	regulator
D3X13_RS07385	COG1802	Transcriptional regulator
D3X13_RS07410	COG0028	Belongs to the TPP enzyme family
D3X13_RS07460	COG2226	methyltransferase
D3X13_RS07465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3X13_RS07470	COG2124	cytochrome p450
D3X13_RS07515	COG0494	nUDIX hydrolase
D3X13_RS07545	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS07560	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3X13_RS07570	COG0175	sulfate reduction
D3X13_RS07575	COG0529	Catalyzes the synthesis of activated sulfate
D3X13_RS07600	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3X13_RS07605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3X13_RS07725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3X13_RS07735	COG0504	CTP synthase activity
D3X13_RS07765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3X13_RS07770	COG0443	Heat shock 70 kDa protein
D3X13_RS07825	COG1129	ABC transporter
D3X13_RS07835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS07840	COG1869	D-ribose catabolic process
D3X13_RS07845	COG4935	Belongs to the peptidase S8 family
D3X13_RS07845	COG2234	aminopeptidase activity
D3X13_RS07850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3X13_RS07855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3X13_RS07885	COG2226	methyltransferase
D3X13_RS07895	COG2267	carboxylic ester hydrolase activity
D3X13_RS07920	COG1116	anion transmembrane transporter activity
D3X13_RS07935	COG3220	belongs to the UPF0276 family
D3X13_RS07955	COG0596	Alpha beta hydrolase
D3X13_RS07960	COG3253	May function as heme-dependent peroxidase
D3X13_RS07965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D3X13_RS07975	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3X13_RS07985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D3X13_RS08000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3X13_RS08005	COG0183	Belongs to the thiolase family
D3X13_RS08010	COG1024	Enoyl-CoA hydratase
D3X13_RS08010	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS08045	COG2843	Capsule synthesis protein
D3X13_RS08060	COG0531	amino acid
D3X13_RS08065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3X13_RS08070	COG4214	carbohydrate transport
D3X13_RS08080	COG4213	ABC transporter substrate-binding protein
D3X13_RS08105	COG0395	ABC-type sugar transport system, permease component
D3X13_RS08115	COG2182	Extracellular solute-binding protein
D3X13_RS08120	COG0395	ABC-type sugar transport system, permease component
D3X13_RS08125	COG1175	transmembrane transport
D3X13_RS08180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3X13_RS08190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3X13_RS08215	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS08235	COG1024	Enoyl-CoA hydratase
D3X13_RS08245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3X13_RS08250	COG2235	arginine
D3X13_RS08255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3X13_RS08305	COG0346	lactoylglutathione lyase activity
D3X13_RS08310	COG1799	cell septum assembly
D3X13_RS08315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3X13_RS08330	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D3X13_RS08370	COG2124	cytochrome p450
D3X13_RS08400	COG0477	Major facilitator Superfamily
D3X13_RS08420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3X13_RS08435	COG1533	DNA photolyase activity
D3X13_RS08455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3X13_RS08475	COG0367	asparagine synthase
D3X13_RS08500	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS08510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3X13_RS08525	COG4310	Domain of unknown function (DUF2172)
D3X13_RS08535	COG1215	transferase activity, transferring glycosyl groups
D3X13_RS08550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D3X13_RS08620	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS08625	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS08645	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS08695	COG4974	Belongs to the 'phage' integrase family
D3X13_RS08715	COG0482	sulfurtransferase activity
D3X13_RS08730	COG1104	cysteine desulfurase activity
D3X13_RS08735	COG1061	Type III restriction enzyme res subunit
D3X13_RS08785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3X13_RS08790	COG0531	amino acid
D3X13_RS08810	COG0569	domain protein
D3X13_RS08840	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3X13_RS08840	COG1136	(ABC) transporter
D3X13_RS08845	COG1136	(ABC) transporter
D3X13_RS08865	COG0756	dUTP diphosphatase activity
D3X13_RS08890	COG2205	protein histidine kinase activity
D3X13_RS08895	COG0745	RESPONSE REGULATOR receiver
D3X13_RS08905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3X13_RS08940	COG1435	thymidine kinase activity
D3X13_RS08960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3X13_RS08975	COG0612	Peptidase, M16
D3X13_RS08980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3X13_RS09000	COG0372	Belongs to the citrate synthase family
D3X13_RS09015	COG3290	protein histidine kinase activity
D3X13_RS09020	COG4565	transcriptional regulatory protein
D3X13_RS09025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3X13_RS09035	COG0187	DNA topoisomerase II activity
D3X13_RS09050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3X13_RS09055	COG2186	Transcriptional regulator
D3X13_RS09060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3X13_RS09080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3X13_RS09105	COG2382	esterase
D3X13_RS09110	COG1132	(ABC) transporter
D3X13_RS09120	COG1132	(ABC) transporter
D3X13_RS09130	COG1120	ATPase activity
D3X13_RS09135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS09145	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D3X13_RS09170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3X13_RS09220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3X13_RS09225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3X13_RS09230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3X13_RS09270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3X13_RS09280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3X13_RS09285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3X13_RS09295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3X13_RS09310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3X13_RS09320	COG2205	protein histidine kinase activity
D3X13_RS09330	COG1126	abc transporter atp-binding protein
D3X13_RS09340	COG0765	amino acid transport
D3X13_RS09345	COG0765	amino acid transport
D3X13_RS09360	COG2897	thiosulfate sulfurtransferase activity
D3X13_RS09380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3X13_RS09385	COG0628	permease
D3X13_RS09400	COG1201	RNA secondary structure unwinding
D3X13_RS09405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3X13_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS09420	COG0783	Belongs to the Dps family
D3X13_RS09425	COG1396	sequence-specific DNA binding
D3X13_RS09430	COG1546	Belongs to the CinA family
D3X13_RS09430	COG1058	Belongs to the CinA family
D3X13_RS09440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3X13_RS09450	COG1674	ftsk spoiiie
D3X13_RS09460	COG3437	response regulator, receiver
D3X13_RS09460	COG4999	Histidine kinase
D3X13_RS09460	COG3850	Histidine kinase
D3X13_RS09460	COG2205	protein histidine kinase activity
D3X13_RS09470	COG2208	phosphoserine phosphatase activity
D3X13_RS09470	COG2770	Histidine kinase
D3X13_RS09510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D3X13_RS09515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3X13_RS09520	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D3X13_RS09540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3X13_RS09545	COG0612	Peptidase, M16
D3X13_RS09550	COG1185	polyribonucleotide nucleotidyltransferase activity
D3X13_RS09555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3X13_RS09590	COG1404	Belongs to the peptidase S8 family
D3X13_RS09605	COG0455	bacterial-type flagellum organization
D3X13_RS09610	COG4166	transmembrane transport
D3X13_RS09615	COG0601	transmembrane transport
D3X13_RS09620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS09625	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS09630	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS09645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3X13_RS09650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3X13_RS09660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D3X13_RS09675	COG0779	Required for maturation of 30S ribosomal subunits
D3X13_RS09690	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
D3X13_RS09695	COG0442	prolyl-tRNA aminoacylation
D3X13_RS09710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3X13_RS09715	COG0750	zinc metalloprotease
D3X13_RS09720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3X13_RS09730	COG0300	oxidoreductase activity
D3X13_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS09740	COG2508	Transcriptional regulator
D3X13_RS09740	COG2508	Transcriptional regulator
D3X13_RS09770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS09775	COG1177	transmembrane transport
D3X13_RS09780	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3X13_RS09785	COG3842	ATPase activity
D3X13_RS09795	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS09810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3X13_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS09850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3X13_RS09880	COG3842	ATPase activity
D3X13_RS09895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3X13_RS09900	COG0575	Belongs to the CDS family
D3X13_RS09905	COG0233	cytoplasmic translational termination
D3X13_RS09910	COG0528	UMP kinase activity
D3X13_RS09915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3X13_RS09920	COG0052	Belongs to the universal ribosomal protein uS2 family
D3X13_RS09935	COG1191	sigma factor activity
D3X13_RS09950	COG0792	nuclease activity
D3X13_RS09960	COG1051	belongs to the nudix hydrolase family
D3X13_RS09970	COG0681	Belongs to the peptidase S26 family
D3X13_RS09985	COG0335	large ribosomal subunit rRNA binding
D3X13_RS09990	COG0336	Belongs to the RNA methyltransferase TrmD family
D3X13_RS09995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3X13_RS10000	COG1837	Belongs to the UPF0109 family
D3X13_RS10005	COG0228	four-way junction DNA binding
D3X13_RS10020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3X13_RS10030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3X13_RS10060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D3X13_RS10070	COG0477	Major facilitator Superfamily
D3X13_RS10075	COG1196	nuclear chromosome segregation
D3X13_RS10085	COG1254	Belongs to the acylphosphatase family
D3X13_RS10095	COG1733	regulation of RNA biosynthetic process
D3X13_RS10100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3X13_RS10105	COG0571	ribonuclease III activity
D3X13_RS10110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3X13_RS10125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3X13_RS10130	COG0742	ribosomal rna small subunit methyltransferase
D3X13_RS10140	COG1461	Dihydroxyacetone kinase
D3X13_RS10145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3X13_RS10155	COG0351	phosphomethylpyrimidine kinase
D3X13_RS10175	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3X13_RS10180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3X13_RS10190	COG1920	GTP binding
D3X13_RS10200	COG0776	regulation of translation
D3X13_RS10210	COG0066	3-isopropylmalate dehydratase activity
D3X13_RS10215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3X13_RS10220	COG1414	Transcriptional regulator
D3X13_RS10260	COG1011	Hydrolase
D3X13_RS10265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3X13_RS10270	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3X13_RS10280	COG5002	protein histidine kinase activity
D3X13_RS10285	COG2018	Roadblock/LC7 domain
D3X13_RS10305	COG2018	Roadblock/LC7 domain
D3X13_RS10335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3X13_RS10360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3X13_RS10380	COG2957	Belongs to the agmatine deiminase family
D3X13_RS10385	COG0804	urea catabolic process
D3X13_RS10390	COG0832	Belongs to the urease beta subunit family
D3X13_RS10390	COG0831	urea catabolic process
D3X13_RS10405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3X13_RS10410	COG0473	3-isopropylmalate dehydrogenase activity
D3X13_RS10440	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS10445	COG0506	proline dehydrogenase activity
D3X13_RS10450	COG3835	regulator
D3X13_RS10465	COG0477	Major facilitator Superfamily
D3X13_RS10470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3X13_RS10475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3X13_RS10480	COG0440	acetolactate synthase activity
D3X13_RS10505	COG0667	Aldo Keto reductase
D3X13_RS10520	COG2197	response regulator
D3X13_RS10535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3X13_RS10540	COG2409	Drug exporters of the RND superfamily
D3X13_RS10550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3X13_RS10560	COG0154	amidase activity
D3X13_RS10565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3X13_RS10575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3X13_RS10585	COG4221	oxidoreductase activity
D3X13_RS10600	COG0482	sulfurtransferase activity
D3X13_RS10635	COG2860	membrane
D3X13_RS10640	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS10645	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS10650	COG0601	transmembrane transport
D3X13_RS10655	COG4166	transmembrane transport
D3X13_RS10660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS10680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3X13_RS10685	COG0509	glycine decarboxylation via glycine cleavage system
D3X13_RS10690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3X13_RS10695	COG1760	l-serine dehydratase
D3X13_RS10705	COG1119	ATPase activity
D3X13_RS10710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3X13_RS10715	COG2186	Transcriptional regulator
D3X13_RS10735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3X13_RS10770	COG1376	ErfK ybiS ycfS ynhG family protein
D3X13_RS10795	COG1132	(ABC) transporter
D3X13_RS10800	COG1132	(ABC) transporter
D3X13_RS10815	COG0058	SHG alpha-glucan phosphorylase activity
D3X13_RS10820	COG0515	serine threonine protein kinase
D3X13_RS10820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3X13_RS10830	COG0366	Alpha amylase catalytic
D3X13_RS10845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3X13_RS10850	COG3973	AAA domain
D3X13_RS10850	COG3973	AAA domain
D3X13_RS10855	COG0492	ferredoxin-NADP+ reductase activity
D3X13_RS10855	COG3118	belongs to the thioredoxin family
D3X13_RS10885	COG0477	Major facilitator Superfamily
D3X13_RS10895	COG1301	dicarboxylic acid transport
D3X13_RS10905	COG4565	transcriptional regulatory protein
D3X13_RS10915	COG1175	transmembrane transport
D3X13_RS10920	COG0395	ABC-type sugar transport system, permease component
D3X13_RS10935	COG0205	6-phosphofructokinase activity
D3X13_RS10940	COG0280	phosphate acetyltransferase
D3X13_RS10940	COG0857	belongs to the CobB CobQ family
D3X13_RS10945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3X13_RS10990	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3X13_RS10990	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3X13_RS11050	COG2205	protein histidine kinase activity
D3X13_RS11055	COG0745	RESPONSE REGULATOR receiver
D3X13_RS11070	COG0183	Belongs to the thiolase family
D3X13_RS11125	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D3X13_RS11140	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS11170	COG3850	Histidine kinase
D3X13_RS11175	COG2197	response regulator
D3X13_RS11190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3X13_RS11195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3X13_RS11200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3X13_RS11205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3X13_RS11210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3X13_RS11215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3X13_RS11220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3X13_RS11240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3X13_RS11245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3X13_RS11255	COG2890	protein-(glutamine-N5) methyltransferase activity
D3X13_RS11260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3X13_RS11265	COG0254	rRNA binding
D3X13_RS11280	COG0083	homoserine kinase activity
D3X13_RS11285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3X13_RS11290	COG0460	homoserine dehydrogenase
D3X13_RS11295	COG0019	diaminopimelate decarboxylase activity
D3X13_RS11300	COG0018	arginyl-trna synthetase
D3X13_RS11345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS11365	COG2814	Major facilitator Superfamily
D3X13_RS11375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D3X13_RS11385	COG1793	dna ligase
D3X13_RS11405	COG2205	protein histidine kinase activity
D3X13_RS11415	COG0772	Belongs to the SEDS family
D3X13_RS11420	COG0768	penicillin binding
D3X13_RS11490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3X13_RS11510	COG0745	RESPONSE REGULATOR receiver
D3X13_RS11515	COG2205	protein histidine kinase activity
D3X13_RS11520	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3X13_RS11520	COG0567	Dehydrogenase, E1 component
D3X13_RS11570	COG0765	amino acid transport
D3X13_RS11575	COG1126	abc transporter atp-binding protein
D3X13_RS11580	COG4106	trans-aconitate 2-methyltransferase activity
D3X13_RS11605	COG2197	response regulator
D3X13_RS11630	COG1011	Hydrolase
D3X13_RS11650	COG0142	geranyltranstransferase activity
D3X13_RS11655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3X13_RS11670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D3X13_RS11685	COG2172	sigma factor antagonist activity
D3X13_RS11700	COG1597	lipid kinase activity
D3X13_RS11715	COG1309	transcriptional regulator
D3X13_RS11720	COG0363	glucosamine-6-phosphate deaminase activity
D3X13_RS11725	COG1472	Belongs to the glycosyl hydrolase 3 family
D3X13_RS11730	COG0395	ABC-type sugar transport system, permease component
D3X13_RS11735	COG1175	transmembrane transport
D3X13_RS11740	COG2182	Extracellular solute-binding protein
D3X13_RS11745	COG2188	Transcriptional regulator
D3X13_RS11750	COG1966	Carbon starvation protein
D3X13_RS11775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3X13_RS11780	COG2124	cytochrome p450
D3X13_RS11790	COG0242	peptide deformylase activity
D3X13_RS11805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3X13_RS11805	COG2199	diguanylate cyclase activity
D3X13_RS11810	COG5662	AntiSigma factor
D3X13_RS11815	COG1595	DNA-templated transcription, initiation
D3X13_RS11825	COG2135	peptidase activity
D3X13_RS11835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D3X13_RS11845	COG2076	Multidrug Resistance protein
D3X13_RS11855	COG0483	inositol monophosphate 1-phosphatase activity
D3X13_RS11865	COG0753	catalase activity
D3X13_RS11900	COG1615	UPF0182 protein
D3X13_RS11910	COG3480	Lon protease (S16) C-terminal proteolytic domain
D3X13_RS11960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3X13_RS12000	COG1136	(ABC) transporter
D3X13_RS12020	COG2816	NAD+ diphosphatase activity
D3X13_RS12025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3X13_RS12030	COG0210	DNA helicase
D3X13_RS12055	COG0596	Alpha beta hydrolase
D3X13_RS12125	COG0513	Belongs to the DEAD box helicase family
D3X13_RS12135	COG1432	Conserved Protein
D3X13_RS12140	COG2095	MarC family integral membrane protein
D3X13_RS12155	COG2814	Major facilitator Superfamily
D3X13_RS12165	COG0598	Magnesium transport protein CorA
D3X13_RS12200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3X13_RS12205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3X13_RS12230	COG1024	Enoyl-CoA hydratase
D3X13_RS12235	COG2818	Glycosylase
D3X13_RS12245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3X13_RS12255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3X13_RS12295	COG2197	response regulator
D3X13_RS12300	COG4585	Histidine kinase
D3X13_RS12310	COG1131	(ABC) transporter
D3X13_RS12330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3X13_RS12355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS12360	COG0601	transmembrane transport
D3X13_RS12365	COG4166	transmembrane transport
D3X13_RS12370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS12375	COG4166	transmembrane transport
D3X13_RS12380	COG0601	transmembrane transport
D3X13_RS12385	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS12390	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS12395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3X13_RS12400	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS12405	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS12410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS12415	COG0601	transmembrane transport
D3X13_RS12425	COG1217	gtp-binding protein TYPA
D3X13_RS12545	COG0477	Major facilitator Superfamily
D3X13_RS12575	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS12585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3X13_RS12610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS12615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS12620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3X13_RS12625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3X13_RS12630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3X13_RS12635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3X13_RS12640	COG2814	Major facilitator Superfamily
D3X13_RS12660	COG3629	intracellular signal transduction
D3X13_RS12670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3X13_RS12680	COG2197	response regulator
D3X13_RS12690	COG1131	(ABC) transporter
D3X13_RS12710	COG0012	GTP binding
D3X13_RS12725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3X13_RS12730	COG1113	amino acid transport
D3X13_RS12735	COG1570	exodeoxyribonuclease VII activity
D3X13_RS12740	COG1722	exodeoxyribonuclease VII activity
D3X13_RS12745	COG0778	Nitroreductase
D3X13_RS12775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3X13_RS12775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3X13_RS12780	COG0114	fumarate hydratase activity
D3X13_RS12800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3X13_RS12810	COG1136	(ABC) transporter
D3X13_RS12825	COG0450	alkyl hydroperoxide reductase
D3X13_RS12830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS12845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D3X13_RS12850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3X13_RS12855	COG0667	Aldo Keto reductase
D3X13_RS12870	COG2885	chlorophyll binding
D3X13_RS12940	COG2610	gluconate transmembrane transporter activity
D3X13_RS12945	COG0251	oxidation-reduction process
D3X13_RS12950	COG1414	Transcriptional regulator
D3X13_RS12965	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D3X13_RS12970	COG0513	Belongs to the DEAD box helicase family
D3X13_RS12975	COG1278	Cold shock
D3X13_RS12990	COG0071	Belongs to the small heat shock protein (HSP20) family
D3X13_RS13015	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3X13_RS13025	COG0477	Major facilitator Superfamily
D3X13_RS13030	COG1309	transcriptional regulator
D3X13_RS13040	COG1331	Highly conserved protein containing a thioredoxin domain
D3X13_RS13060	COG0488	(ABC) transporter
D3X13_RS13090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3X13_RS13100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3X13_RS13115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3X13_RS13120	COG2255	four-way junction helicase activity
D3X13_RS13125	COG1595	DNA-templated transcription, initiation
D3X13_RS13145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3X13_RS13155	COG0740	serine-type endopeptidase activity
D3X13_RS13160	COG0740	serine-type endopeptidase activity
D3X13_RS13175	COG1064	alcohol dehydrogenase
D3X13_RS13185	COG1733	regulation of RNA biosynthetic process
D3X13_RS13195	COG1376	ErfK ybiS ycfS ynhG family protein
D3X13_RS13210	COG2986	histidine ammonia-lyase
D3X13_RS13220	COG1024	Enoyl-CoA hydratase
D3X13_RS13225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3X13_RS13235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3X13_RS13245	COG0424	maF-like protein
D3X13_RS13255	COG4770	biotin carboxylase activity
D3X13_RS13285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3X13_RS13305	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS13310	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS13325	COG1595	DNA-templated transcription, initiation
D3X13_RS13330	COG0745	RESPONSE REGULATOR receiver
D3X13_RS13335	COG2205	protein histidine kinase activity
D3X13_RS13360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3X13_RS13370	COG0583	DNA-binding transcription factor activity
D3X13_RS13375	COG2814	Major facilitator Superfamily
D3X13_RS13405	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS13410	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3X13_RS13415	COG3845	ABC transporter
D3X13_RS13420	COG1744	ABC transporter substrate-binding protein PnrA-like
D3X13_RS13425	COG1744	ABC transporter substrate-binding protein PnrA-like
D3X13_RS13430	COG1473	amidohydrolase
D3X13_RS13430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3X13_RS13450	COG2089	acid synthase
D3X13_RS13465	COG1216	Glycosyl transferase, family 2
D3X13_RS13475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3X13_RS13510	COG1595	DNA-templated transcription, initiation
D3X13_RS13520	COG1595	DNA-templated transcription, initiation
D3X13_RS13545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D3X13_RS13555	COG2009	succinate dehydrogenase
D3X13_RS13565	COG1053	succinate dehydrogenase
D3X13_RS13590	COG1408	metallophosphoesterase
D3X13_RS13600	COG1686	Belongs to the peptidase S11 family
D3X13_RS13605	COG1295	ribonuclease BN
D3X13_RS13620	COG0671	phosphoesterase, PA-phosphatase related
D3X13_RS13640	COG0180	Tryptophanyl-tRNA synthetase
D3X13_RS13645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3X13_RS13650	COG0754	glutathionylspermidine amidase activity
D3X13_RS13660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3X13_RS13665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS13670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS13675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3X13_RS13685	COG4176	ABC-type proline glycine betaine transport system permease component
D3X13_RS13690	COG4175	Glycine betaine
D3X13_RS13690	COG0517	IMP dehydrogenase activity
D3X13_RS13700	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS13710	COG1476	TRANSCRIPTIONal
D3X13_RS13730	COG0039	L-malate dehydrogenase activity
D3X13_RS13745	COG2197	response regulator
D3X13_RS13750	COG4585	Histidine kinase
D3X13_RS13760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3X13_RS13770	COG0138	bifunctional purine biosynthesis protein purh
D3X13_RS13805	COG0045	succinate-CoA ligase (ADP-forming) activity
D3X13_RS13810	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D3X13_RS13820	COG0714	Associated with various cellular activities
D3X13_RS13835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3X13_RS13835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3X13_RS13865	COG0791	NLP P60 protein
D3X13_RS13870	COG2197	response regulator
D3X13_RS13905	COG0519	Catalyzes the synthesis of GMP from XMP
D3X13_RS13905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3X13_RS13940	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS13945	COG0515	serine threonine protein kinase
D3X13_RS13950	COG0515	serine threonine protein kinase
D3X13_RS13955	COG0515	serine threonine protein kinase
D3X13_RS13970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3X13_RS13980	COG0516	GMP reductase activity
D3X13_RS13990	COG1595	DNA-templated transcription, initiation
D3X13_RS14005	COG0583	DNA-binding transcription factor activity
D3X13_RS14015	COG4221	oxidoreductase activity
D3X13_RS14020	COG0459	protein refolding
D3X13_RS14035	COG0726	polysaccharide deacetylase
D3X13_RS14045	COG4941	Belongs to the sigma-70 factor family
D3X13_RS14065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3X13_RS14090	COG0802	atpase or kinase
D3X13_RS14100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3X13_RS14110	COG0736	holo-[acyl-carrier-protein] synthase activity
D3X13_RS14115	COG1072	(Pantothenic acid kinase))
D3X13_RS14125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3X13_RS14130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3X13_RS14135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3X13_RS14150	COG0101	tRNA pseudouridine synthase activity
D3X13_RS14155	COG0203	ribosomal protein L17
D3X13_RS14160	COG0202	RNA polymerase activity
D3X13_RS14165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3X13_RS14170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3X13_RS14175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3X13_RS14180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3X13_RS14190	COG0563	adenylate kinase activity
D3X13_RS14200	COG0200	Binds to the 23S rRNA
D3X13_RS14205	COG1841	ribosomal large subunit assembly
D3X13_RS14210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3X13_RS14215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D3X13_RS14220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3X13_RS14225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3X13_RS14235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3X13_RS14240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3X13_RS14245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3X13_RS14250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D3X13_RS14255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3X13_RS14260	COG0255	Belongs to the universal ribosomal protein uL29 family
D3X13_RS14265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3X13_RS14270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3X13_RS14275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3X13_RS14280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3X13_RS14285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3X13_RS14290	COG0089	rRNA binding
D3X13_RS14295	COG0088	Forms part of the polypeptide exit tunnel
D3X13_RS14300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3X13_RS14305	COG0051	transcription antitermination factor activity, RNA binding
D3X13_RS14340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3X13_RS14345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3X13_RS14350	COG0049	tRNA binding
D3X13_RS14355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D3X13_RS14370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3X13_RS14375	COG0085	RNA polymerase activity
D3X13_RS14385	COG0222	ribosome binding
D3X13_RS14390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3X13_RS14405	COG0081	regulation of translation
D3X13_RS14410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3X13_RS14420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3X13_RS14430	COG0436	Aminotransferase
D3X13_RS14435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3X13_RS14450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3X13_RS14460	COG2030	dehydratase
D3X13_RS14465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3X13_RS14480	COG0402	S-adenosylhomocysteine deaminase activity
D3X13_RS14485	COG0702	epimerase
D3X13_RS14500	COG1666	GTP binding
D3X13_RS14510	COG2261	transglycosylase associated protein
D3X13_RS14515	COG3304	Inner membrane component domain
D3X13_RS14520	COG0501	Belongs to the peptidase M48B family
D3X13_RS14525	COG1007	ATP synthesis coupled electron transport
D3X13_RS14535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3X13_RS14540	COG0713	ATP synthesis coupled electron transport
D3X13_RS14545	COG0839	Belongs to the complex I subunit 6 family
D3X13_RS14550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3X13_RS14560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3X13_RS14590	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3X13_RS14595	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3X13_RS14600	COG1733	regulation of RNA biosynthetic process
D3X13_RS14605	COG0702	epimerase
D3X13_RS14625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3X13_RS14645	COG0142	geranyltranstransferase activity
D3X13_RS14650	COG3104	oligopeptide transport
D3X13_RS14655	COG2936	dipeptidyl-peptidase activity
D3X13_RS14660	COG0561	phosphatase activity
D3X13_RS14670	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3X13_RS14680	COG1007	ATP synthesis coupled electron transport
D3X13_RS14690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3X13_RS14695	COG0713	ATP synthesis coupled electron transport
D3X13_RS14700	COG0839	Belongs to the complex I subunit 6 family
D3X13_RS14705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3X13_RS14715	COG1034	ATP synthesis coupled electron transport
D3X13_RS14720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D3X13_RS14730	COG0649	NAD binding
D3X13_RS14735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3X13_RS14750	COG1388	LysM domain
D3X13_RS14750	COG3103	Sh3 type 3 domain protein
D3X13_RS14750	COG0791	NLP P60 protein
D3X13_RS14775	COG2226	methyltransferase
D3X13_RS14785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3X13_RS14830	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D3X13_RS14845	COG2318	DinB family
D3X13_RS14900	COG1674	ftsk spoiiie
D3X13_RS14915	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D3X13_RS14925	COG1278	Cold shock
D3X13_RS14930	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS14940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS14950	COG0747	negative chemotaxis
D3X13_RS15020	COG1309	transcriptional regulator
D3X13_RS15025	COG1301	dicarboxylic acid transport
D3X13_RS15040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3X13_RS15050	COG0163	prenyltransferase activity
D3X13_RS15060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3X13_RS15080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3X13_RS15085	COG1333	cytochrome c biogenesis protein
D3X13_RS15090	COG0785	Cytochrome C biogenesis protein
D3X13_RS15105	COG0406	alpha-ribazole phosphatase activity
D3X13_RS15110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D3X13_RS15120	COG0431	NADPH-dependent FMN reductase
D3X13_RS15125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS15140	COG1742	UPF0060 membrane protein
D3X13_RS15155	COG1690	Belongs to the RtcB family
D3X13_RS15175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D3X13_RS15180	COG0018	arginyl-trna synthetase
D3X13_RS15185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3X13_RS15215	COG3321	synthase
D3X13_RS15215	COG0604	alcohol dehydrogenase
D3X13_RS15220	COG0113	porphobilinogen synthase activity
D3X13_RS15225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3X13_RS15225	COG1648	precorrin-2 dehydrogenase activity
D3X13_RS15230	COG0181	hydroxymethylbilane synthase activity
D3X13_RS15235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3X13_RS15240	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D3X13_RS15290	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3X13_RS15300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3X13_RS15325	COG0180	Tryptophanyl-tRNA synthetase
D3X13_RS15330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3X13_RS15350	COG0129	dihydroxy-acid dehydratase activity
D3X13_RS15355	COG1082	Xylose isomerase domain protein TIM barrel
D3X13_RS15360	COG0248	Ppx GppA phosphatase
D3X13_RS15380	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D3X13_RS15390	COG0671	phosphoesterase, PA-phosphatase related
D3X13_RS15405	COG1194	a g-specific adenine glycosylase
D3X13_RS15410	COG1595	DNA-templated transcription, initiation
D3X13_RS15420	COG0745	RESPONSE REGULATOR receiver
D3X13_RS15425	COG2205	protein histidine kinase activity
D3X13_RS15430	COG0477	Major facilitator Superfamily
D3X13_RS15440	COG0739	heme binding
D3X13_RS15465	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3X13_RS15480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D3X13_RS15490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3X13_RS15495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3X13_RS15535	COG0649	NAD binding
D3X13_RS15560	COG1174	glycine betaine transport
D3X13_RS15565	COG1174	glycine betaine transport
D3X13_RS15595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3X13_RS15600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3X13_RS15610	COG0302	gtp cyclohydrolase
D3X13_RS15625	COG0037	tRNA processing
D3X13_RS15635	COG2027	D-alanyl-D-alanine carboxypeptidase
D3X13_RS15640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3X13_RS15655	COG0789	Transcriptional regulator
D3X13_RS15665	COG2318	DinB family
D3X13_RS15675	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS15695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3X13_RS15705	COG0254	rRNA binding
D3X13_RS15710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3X13_RS15715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3X13_RS15720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3X13_RS15730	COG1289	transmembrane transporter activity
D3X13_RS15740	COG1136	(ABC) transporter
D3X13_RS15750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3X13_RS15750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3X13_RS15755	COG5002	protein histidine kinase activity
D3X13_RS15760	COG0745	RESPONSE REGULATOR receiver
D3X13_RS15785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3X13_RS15790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS15810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS15820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3X13_RS15825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS15830	COG3629	intracellular signal transduction
D3X13_RS15880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS15895	COG2197	response regulator
D3X13_RS15925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D3X13_RS15930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3X13_RS15935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3X13_RS15935	COG1754	DNA topoisomerase type I activity
D3X13_RS15945	COG2890	protein-(glutamine-N5) methyltransferase activity
D3X13_RS15955	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3X13_RS15965	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS16030	COG0288	reversible hydration of carbon dioxide
D3X13_RS16035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3X13_RS16040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3X13_RS16050	COG2267	carboxylic ester hydrolase activity
D3X13_RS16080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3X13_RS16105	COG0003	Pfam Anion-transporting ATPase
D3X13_RS16120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3X13_RS16130	COG1408	metallophosphoesterase
D3X13_RS16205	COG4249	Peptidase C14 caspase catalytic subunit p20
D3X13_RS16205	COG2319	Wd-40 repeat
D3X13_RS16265	COG2304	oxidoreductase activity
D3X13_RS16295	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS16300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3X13_RS16310	COG0728	peptidoglycan biosynthetic process
D3X13_RS16320	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS16345	COG2072	flavoprotein involved in K transport
D3X13_RS16395	COG1595	DNA-templated transcription, initiation
D3X13_RS16415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3X13_RS16420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3X13_RS16435	COG0463	Glycosyl transferase, family 2
D3X13_RS16445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3X13_RS16460	COG0745	RESPONSE REGULATOR receiver
D3X13_RS16480	COG0693	protein deglycase activity
D3X13_RS16490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3X13_RS16490	COG0515	serine threonine protein kinase
D3X13_RS16495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3X13_RS16500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3X13_RS16515	COG1131	(ABC) transporter
D3X13_RS16520	COG3559	Exporter of polyketide antibiotics
D3X13_RS16525	COG2124	cytochrome p450
D3X13_RS16530	COG2197	response regulator
D3X13_RS16535	COG4585	Histidine kinase
D3X13_RS16550	COG3844	kynureninase activity
D3X13_RS16575	COG0191	fructose-bisphosphate aldolase activity
D3X13_RS16580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3X13_RS16615	COG0542	response to heat
D3X13_RS16645	COG0789	Transcriptional regulator
D3X13_RS16650	COG0484	heat shock protein binding
D3X13_RS16655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3X13_RS16660	COG0443	Heat shock 70 kDa protein
D3X13_RS16665	COG2181	nitrate reductase activity
D3X13_RS16665	COG0247	lactate metabolic process
D3X13_RS16710	COG0717	Belongs to the dCTP deaminase family
D3X13_RS16755	COG2197	response regulator
D3X13_RS16775	COG1309	transcriptional regulator
D3X13_RS16815	COG0583	DNA-binding transcription factor activity
D3X13_RS16845	COG1289	transmembrane transporter activity
D3X13_RS16855	COG0583	DNA-binding transcription factor activity
D3X13_RS16870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3X13_RS16875	COG1309	transcriptional regulator
D3X13_RS16890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3X13_RS16905	COG1741	Belongs to the pirin family
D3X13_RS16915	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS16925	COG1362	aminopeptidase activity
D3X13_RS16945	COG2271	Major facilitator Superfamily
D3X13_RS16960	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3X13_RS16965	COG0022	dehydrogenase e1 component
D3X13_RS16985	COG0515	serine threonine protein kinase
D3X13_RS16990	COG0515	serine threonine protein kinase
D3X13_RS17005	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS17005	COG3321	synthase
D3X13_RS17005	COG0604	alcohol dehydrogenase
D3X13_RS17010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3X13_RS17015	COG0303	'Molybdopterin
D3X13_RS17040	COG1522	sequence-specific DNA binding
D3X13_RS17045	COG1309	transcriptional regulator
D3X13_RS17050	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3X13_RS17060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3X13_RS17075	COG3396	Phenylacetate-CoA oxygenase
D3X13_RS17080	COG3460	Phenylacetate-CoA oxygenase
D3X13_RS17085	COG3396	Phenylacetate-CoA oxygenase
D3X13_RS17090	COG2151	metal-sulfur cluster biosynthetic enzyme
D3X13_RS17095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3X13_RS17100	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS17105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3X13_RS17125	COG1716	ATPase activity
D3X13_RS17130	COG1716	ATPase activity
D3X13_RS17155	COG0515	serine threonine protein kinase
D3X13_RS17160	COG3764	Sortase (surface protein transpeptidase)
D3X13_RS17180	COG3764	Sortase (surface protein transpeptidase)
D3X13_RS17195	COG0705	Rhomboid family
D3X13_RS17220	COG0515	serine threonine protein kinase
D3X13_RS17250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3X13_RS17260	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D3X13_RS17265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3X13_RS17270	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D3X13_RS17275	COG0592	DNA-directed DNA polymerase activity
D3X13_RS17285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3X13_RS17290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3X13_RS17295	COG0594	ribonuclease P activity
D3X13_RS17300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3X13_RS17305	COG0706	membrane insertase activity
D3X13_RS17315	COG0357	Ribosomal RNA small subunit methyltransferase G
D3X13_RS17320	COG1192	Involved in chromosome partitioning
D3X13_RS17335	COG3118	belongs to the thioredoxin family
D3X13_RS17340	COG0492	ferredoxin-NADP+ reductase activity
D3X13_RS17350	COG1595	DNA-templated transcription, initiation
D3X13_RS17370	COG0617	tRNA 3'-terminal CCA addition
D3X13_RS17385	COG1260	myo-inositol-1-phosphate synthase
D3X13_RS17395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3X13_RS17420	COG0360	Binds together with S18 to 16S ribosomal RNA
D3X13_RS17425	COG0629	single-stranded DNA binding
D3X13_RS17430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3X13_RS17435	COG0359	binds to the 23S rRNA
D3X13_RS17445	COG0305	Participates in initiation and elongation during chromosome replication
D3X13_RS17465	COG2814	Major facilitator Superfamily
D3X13_RS17500	COG0626	cystathionine gamma-synthase activity
D3X13_RS17505	COG1950	PFAM Membrane protein of
D3X13_RS17510	COG0662	Cupin 2, conserved barrel domain protein
D3X13_RS17535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3X13_RS17550	COG1609	Transcriptional regulator
D3X13_RS17555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3X13_RS17560	COG1271	oxidase subunit
D3X13_RS17565	COG1294	oxidase, subunit
D3X13_RS17570	COG4988	ABC transporter
D3X13_RS17580	COG0561	phosphatase activity
D3X13_RS17595	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D3X13_RS17600	COG0789	Transcriptional regulator
D3X13_RS17635	COG0561	phosphatase activity
D3X13_RS17640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3X13_RS17650	COG2837	iron assimilation
D3X13_RS17665	COG1999	signal sequence binding
D3X13_RS17685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3X13_RS17690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS17700	COG0006	proline dipeptidase activity
D3X13_RS17720	COG0653	protein targeting
D3X13_RS17735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3X13_RS17760	COG0494	nUDIX hydrolase
D3X13_RS17805	COG1595	DNA-templated transcription, initiation
D3X13_RS17810	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS17815	COG0784	Response regulator, receiver
D3X13_RS17840	COG0745	RESPONSE REGULATOR receiver
D3X13_RS17845	COG2205	protein histidine kinase activity
D3X13_RS17855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D3X13_RS17860	COG0477	Major facilitator Superfamily
D3X13_RS17875	COG0477	Major facilitator Superfamily
D3X13_RS17895	COG1191	sigma factor activity
D3X13_RS17900	COG1191	sigma factor activity
D3X13_RS17930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3X13_RS17960	COG0697	spore germination
D3X13_RS18020	COG2197	response regulator
D3X13_RS18055	COG0151	Belongs to the GarS family
D3X13_RS18070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3X13_RS18085	COG2197	response regulator
D3X13_RS18120	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3X13_RS18125	COG0047	phosphoribosylformylglycinamidine synthase activity
D3X13_RS18130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3X13_RS18160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3X13_RS18195	COG1643	Atp-dependent helicase
D3X13_RS18205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3X13_RS18205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3X13_RS18210	COG0785	Cytochrome C biogenesis protein
D3X13_RS18250	COG0513	Belongs to the DEAD box helicase family
D3X13_RS18305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3X13_RS18310	COG0579	oxidoreductase
D3X13_RS18340	COG1252	NADH dehydrogenase
D3X13_RS18375	COG2197	response regulator
D3X13_RS18380	COG4585	Histidine kinase
D3X13_RS18390	COG1131	(ABC) transporter
D3X13_RS18440	COG1196	nuclear chromosome segregation
D3X13_RS18440	COG0741	lytic transglycosylase activity
D3X13_RS18440	COG0739	heme binding
D3X13_RS18445	COG0671	phosphoesterase, PA-phosphatase related
D3X13_RS18450	COG0277	FAD linked oxidase domain protein
D3X13_RS18460	COG1937	Protein conserved in bacteria
D3X13_RS18470	COG0306	phosphate transporter
D3X13_RS18475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3X13_RS18505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3X13_RS18515	COG1116	anion transmembrane transporter activity
D3X13_RS18520	COG1725	Transcriptional regulator
D3X13_RS18525	COG0456	acetyltransferase
D3X13_RS18530	COG0737	Belongs to the 5'-nucleotidase family
D3X13_RS18540	COG0488	(ABC) transporter
D3X13_RS18550	COG0745	RESPONSE REGULATOR receiver
D3X13_RS18555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3X13_RS18560	COG1609	Transcriptional regulator
D3X13_RS18565	COG0745	RESPONSE REGULATOR receiver
D3X13_RS18590	COG2897	thiosulfate sulfurtransferase activity
D3X13_RS18615	COG3485	protocatechuate 3,4-dioxygenase
D3X13_RS18620	COG0735	belongs to the Fur family
D3X13_RS18630	COG1490	D-aminoacyl-tRNA deacylase activity
D3X13_RS18640	COG4552	Acetyltransferase involved in intracellular survival and related
D3X13_RS18650	COG2186	Transcriptional regulator
D3X13_RS18660	COG2188	Transcriptional regulator
D3X13_RS18745	COG0768	penicillin binding
D3X13_RS18765	COG1309	transcriptional regulator
D3X13_RS18815	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS18835	COG0588	phosphoglycerate mutase activity
D3X13_RS18855	COG5002	protein histidine kinase activity
D3X13_RS18875	COG1329	Transcriptional regulator
D3X13_RS18880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3X13_RS18885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3X13_RS18890	COG3467	pyridoxamine 5'-phosphate
D3X13_RS18895	COG0215	cysteine-tRNA ligase activity
D3X13_RS18900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3X13_RS18910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3X13_RS18920	COG3842	ATPase activity
D3X13_RS18930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS18970	COG2197	response regulator
D3X13_RS19005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3X13_RS19030	COG1105	Belongs to the carbohydrate kinase PfkB family
D3X13_RS19045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3X13_RS19070	COG0463	Glycosyl transferase, family 2
D3X13_RS19125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3X13_RS19130	COG1737	Transcriptional regulator
D3X13_RS19185	COG3973	AAA domain
D3X13_RS19195	COG1061	Type III restriction enzyme res subunit
D3X13_RS19220	COG1278	Cold shock
D3X13_RS19225	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D3X13_RS19230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3X13_RS19240	COG2814	Major facilitator Superfamily
D3X13_RS19260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3X13_RS19270	COG2252	PERMEase
D3X13_RS19300	COG0667	Aldo Keto reductase
D3X13_RS19360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3X13_RS19390	COG2205	protein histidine kinase activity
D3X13_RS19395	COG0277	FAD linked oxidase domain protein
D3X13_RS19415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3X13_RS19430	COG1024	Enoyl-CoA hydratase
D3X13_RS19445	COG0259	pyridoxamine-phosphate oxidase activity
D3X13_RS19450	COG2945	thiolester hydrolase activity
D3X13_RS19450	COG0596	Alpha beta hydrolase
D3X13_RS19460	COG4821	SIS domain
D3X13_RS19520	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS19535	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS19540	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS19545	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS19565	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS19580	COG2814	Major facilitator Superfamily
D3X13_RS19585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3X13_RS19590	COG1024	Enoyl-CoA hydratase
D3X13_RS19620	COG0259	pyridoxamine-phosphate oxidase activity
D3X13_RS19630	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS19640	COG1309	transcriptional regulator
D3X13_RS19650	COG0515	serine threonine protein kinase
D3X13_RS19650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3X13_RS19655	COG1024	Enoyl-CoA hydratase
D3X13_RS19695	COG3903	Transcriptional regulator
D3X13_RS19695	COG3629	intracellular signal transduction
D3X13_RS19710	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS19725	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS19735	COG1349	DNA-binding transcription factor activity
D3X13_RS19745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3X13_RS19745	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D3X13_RS19745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3X13_RS19780	COG1970	mechanosensitive ion channel activity
D3X13_RS19790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3X13_RS19810	COG2366	antibiotic biosynthetic process
D3X13_RS19815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3X13_RS19820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3X13_RS19830	COG0315	cyclic pyranopterin monophosphate synthase activity
D3X13_RS19835	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3X13_RS19835	COG0315	cyclic pyranopterin monophosphate synthase activity
D3X13_RS19840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3X13_RS19965	COG2072	flavoprotein involved in K transport
D3X13_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS19985	COG4946	Tricorn protease homolog
D3X13_RS19985	COG0793	Belongs to the peptidase S41A family
D3X13_RS19995	COG2409	Drug exporters of the RND superfamily
D3X13_RS20005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3X13_RS20020	COG1695	Transcriptional regulator
D3X13_RS20035	COG0442	prolyl-tRNA aminoacylation
D3X13_RS20040	COG0768	penicillin binding
D3X13_RS20045	COG0768	penicillin binding
D3X13_RS20065	COG0084	hydrolase, TatD family'
D3X13_RS20070	COG3583	domain protein
D3X13_RS20070	COG3584	3D domain protein
D3X13_RS20075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3X13_RS20080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3X13_RS20090	COG0488	(ABC) transporter
D3X13_RS20130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D3X13_RS20145	COG2197	response regulator
D3X13_RS20150	COG1846	Transcriptional regulator
D3X13_RS20155	COG4106	trans-aconitate 2-methyltransferase activity
D3X13_RS20175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3X13_RS20180	COG0193	aminoacyl-tRNA hydrolase activity
D3X13_RS20185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3X13_RS20190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3X13_RS20195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3X13_RS20210	COG4585	Histidine kinase
D3X13_RS20240	COG0477	Major facilitator Superfamily
D3X13_RS20245	COG1136	(ABC) transporter
D3X13_RS20250	COG0577	efflux transmembrane transporter activity
D3X13_RS20315	COG2124	cytochrome p450
D3X13_RS20330	COG0148	phosphopyruvate hydratase activity
D3X13_RS20360	COG1252	NADH dehydrogenase
D3X13_RS20365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3X13_RS20370	COG0577	efflux transmembrane transporter activity
D3X13_RS20375	COG1136	(ABC) transporter
D3X13_RS20405	COG0183	Belongs to the thiolase family
D3X13_RS20410	COG0515	serine threonine protein kinase
D3X13_RS20415	COG2755	lipolytic protein G-D-S-L family
D3X13_RS20425	COG0778	Nitroreductase
D3X13_RS20440	COG0500	methyltransferase
D3X13_RS20450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS20455	COG0156	8-amino-7-oxononanoate synthase activity
D3X13_RS20460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS20470	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS20480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3X13_RS20485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS20490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS20505	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS20510	COG3629	intracellular signal transduction
D3X13_RS20525	COG2409	Drug exporters of the RND superfamily
D3X13_RS20535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D3X13_RS20545	COG1174	glycine betaine transport
D3X13_RS20550	COG1174	glycine betaine transport
D3X13_RS20560	COG2986	histidine ammonia-lyase
D3X13_RS20595	COG0019	diaminopimelate decarboxylase activity
D3X13_RS20600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3X13_RS20605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3X13_RS20615	COG1228	amidohydrolase
D3X13_RS20635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3X13_RS20635	COG1672	PFAM Archaeal ATPase
D3X13_RS20645	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS20670	COG3104	oligopeptide transport
D3X13_RS20675	COG0745	RESPONSE REGULATOR receiver
D3X13_RS20680	COG2205	protein histidine kinase activity
D3X13_RS20750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3X13_RS20770	COG1316	TRANSCRIPTIONal
D3X13_RS20780	COG1316	TRANSCRIPTIONal
D3X13_RS20795	COG1316	TRANSCRIPTIONal
D3X13_RS20825	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D3X13_RS20825	COG0778	Nitroreductase
D3X13_RS20830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3X13_RS20865	COG1620	l-lactate permease
D3X13_RS20870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3X13_RS20875	COG2835	tetraacyldisaccharide 4'-kinase activity
D3X13_RS20885	COG1482	cell wall glycoprotein biosynthetic process
D3X13_RS20895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3X13_RS20940	COG0714	Associated with various cellular activities
D3X13_RS20960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D3X13_RS20965	COG0745	RESPONSE REGULATOR receiver
D3X13_RS20970	COG5002	protein histidine kinase activity
D3X13_RS20970	COG5000	phosphorelay sensor kinase activity
D3X13_RS20975	COG0823	Involved in the tonB-independent uptake of proteins
D3X13_RS20985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3X13_RS20990	COG2197	response regulator
D3X13_RS20995	COG3214	Protein conserved in bacteria
D3X13_RS21005	COG0653	protein targeting
D3X13_RS21030	COG2902	Dehydrogenase
D3X13_RS21035	COG0463	Glycosyl transferase, family 2
D3X13_RS21045	COG1216	Glycosyl transferase, family 2
D3X13_RS21050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D3X13_RS21055	COG1134	teichoic acid transport
D3X13_RS21065	COG1309	transcriptional regulator
D3X13_RS21075	COG2197	response regulator
D3X13_RS21085	COG0577	efflux transmembrane transporter activity
D3X13_RS21085	COG1136	(ABC) transporter
D3X13_RS21105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D3X13_RS21110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D3X13_RS21115	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS21125	COG0395	ABC-type sugar transport system, permease component
D3X13_RS21130	COG1175	transmembrane transport
D3X13_RS21145	COG0515	serine threonine protein kinase
D3X13_RS21150	COG0515	serine threonine protein kinase
D3X13_RS21155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D3X13_RS21170	COG2884	Cell division ATP-binding protein ftsE
D3X13_RS21175	COG2177	Part of the ABC transporter FtsEX involved in
D3X13_RS21180	COG0793	Belongs to the peptidase S41A family
D3X13_RS21185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3X13_RS21195	COG2027	D-alanyl-D-alanine carboxypeptidase
D3X13_RS21205	COG0583	DNA-binding transcription factor activity
D3X13_RS21235	COG0697	spore germination
D3X13_RS21240	COG1846	Transcriptional regulator
D3X13_RS21245	COG2223	nitrite transmembrane transporter activity
D3X13_RS21270	COG3973	AAA domain
D3X13_RS21285	COG0776	regulation of translation
D3X13_RS21290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3X13_RS21295	COG1678	Uncharacterized ACR, COG1678
D3X13_RS21305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D3X13_RS21340	COG2318	DinB family
D3X13_RS21375	COG3480	Lon protease (S16) C-terminal proteolytic domain
D3X13_RS21395	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D3X13_RS21415	COG0277	FAD linked oxidase domain protein
D3X13_RS21450	COG1335	isochorismatase
D3X13_RS21460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3X13_RS21470	COG1113	amino acid transport
D3X13_RS21495	COG1234	tRNA 3'-trailer cleavage
D3X13_RS21500	COG1263	PTS System
D3X13_RS21505	COG1263	PTS System
D3X13_RS21510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3X13_RS21515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3X13_RS21525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3X13_RS21545	COG0477	Major facilitator Superfamily
D3X13_RS21600	COG2733	membrane
D3X13_RS21605	COG0477	Major facilitator Superfamily
D3X13_RS21605	COG2814	Major facilitator Superfamily
D3X13_RS21610	COG2271	Major facilitator Superfamily
D3X13_RS21625	COG0590	tRNA wobble adenosine to inosine editing
D3X13_RS21660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3X13_RS21670	COG0706	membrane insertase activity
D3X13_RS21680	COG4702	Belongs to the UPF0303 family
D3X13_RS21685	COG0673	inositol 2-dehydrogenase activity
D3X13_RS21700	COG2188	Transcriptional regulator
D3X13_RS21705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS21765	COG2186	Transcriptional regulator
D3X13_RS21780	COG3397	chitin binding
D3X13_RS21800	COG2409	Drug exporters of the RND superfamily
D3X13_RS21810	COG4585	Histidine kinase
D3X13_RS21820	COG4585	Histidine kinase
D3X13_RS21825	COG0586	Pfam SNARE associated Golgi protein
D3X13_RS21840	COG1126	abc transporter atp-binding protein
D3X13_RS21845	COG0765	amino acid transport
D3X13_RS21865	COG0154	amidase activity
D3X13_RS21895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS21945	COG0406	alpha-ribazole phosphatase activity
D3X13_RS21970	COG0745	RESPONSE REGULATOR receiver
D3X13_RS21990	COG0395	ABC-type sugar transport system, permease component
D3X13_RS22050	COG1388	LysM domain
D3X13_RS22050	COG0791	NLP P60 protein
D3X13_RS22080	COG5280	Phage tail tape measure protein TP901
D3X13_RS22080	COG3953	SLT domain
D3X13_RS22140	COG4695	Portal protein
D3X13_RS22350	COG5002	protein histidine kinase activity
D3X13_RS22350	COG2176	DNA-directed DNA polymerase activity
D3X13_RS22425	COG0582	viral genome integration into host DNA
D3X13_RS22435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D3X13_RS22440	COG4977	sequence-specific DNA binding
D3X13_RS22450	COG0589	response to stress
D3X13_RS22455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3X13_RS22480	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS22495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3X13_RS22500	COG1309	transcriptional regulator
D3X13_RS22505	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS22510	COG1946	Acyl-CoA thioesterase
D3X13_RS22530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3X13_RS22540	COG0028	Belongs to the TPP enzyme family
D3X13_RS22585	COG1472	Belongs to the glycosyl hydrolase 3 family
D3X13_RS22605	COG0456	acetyltransferase
D3X13_RS22605	COG1846	Transcriptional regulator
D3X13_RS22610	COG1280	lysine exporter protein (LysE YggA)
D3X13_RS22620	COG1609	Transcriptional regulator
D3X13_RS22625	COG0673	inositol 2-dehydrogenase activity
D3X13_RS22640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3X13_RS22670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS22680	COG3718	enzyme involved in inositol metabolism
D3X13_RS22685	COG3962	Belongs to the TPP enzyme family
D3X13_RS22705	COG1131	(ABC) transporter
D3X13_RS22725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D3X13_RS22765	COG0629	single-stranded DNA binding
D3X13_RS22790	COG2346	COG2346, Truncated hemoglobins
D3X13_RS22795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3X13_RS22825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3X13_RS22840	COG1486	melibiose metabolic process
D3X13_RS22845	COG0395	ABC-type sugar transport system, permease component
D3X13_RS22850	COG1175	transmembrane transport
D3X13_RS22860	COG1846	Transcriptional regulator
D3X13_RS22860	COG1940	carbohydrate kinase activity
D3X13_RS22870	COG0668	transmembrane transport
D3X13_RS22905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3X13_RS22935	COG0583	DNA-binding transcription factor activity
D3X13_RS22990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D3X13_RS23000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3X13_RS23005	COG1113	amino acid transport
D3X13_RS23010	COG1113	amino acid transport
D3X13_RS23015	COG1268	BioY protein
D3X13_RS23020	COG1113	amino acid transport
D3X13_RS23035	COG4552	Acetyltransferase involved in intracellular survival and related
D3X13_RS23045	COG0475	glutathione-regulated potassium exporter activity
D3X13_RS23050	COG1136	(ABC) transporter
D3X13_RS23065	COG3594	Acyltransferase
D3X13_RS23085	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3X13_RS23090	COG0740	serine-type endopeptidase activity
D3X13_RS23095	COG0740	serine-type endopeptidase activity
D3X13_RS23100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3X13_RS23125	COG0525	valine-tRNA ligase activity
D3X13_RS23135	COG1077	Cell shape determining protein MreB Mrl
D3X13_RS23140	COG0285	dihydrofolate synthase activity
D3X13_RS23150	COG0105	UTP biosynthetic process
D3X13_RS23155	COG1077	Cell shape determining protein MreB Mrl
D3X13_RS23170	COG0768	penicillin binding
D3X13_RS23175	COG0772	Belongs to the SEDS family
D3X13_RS23205	COG1530	ribonuclease E activity
D3X13_RS23215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3X13_RS23220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3X13_RS23225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3X13_RS23235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3X13_RS23245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3X13_RS23260	COG0501	Belongs to the peptidase M48B family
D3X13_RS23270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3X13_RS23280	COG0799	negative regulation of ribosome biogenesis
D3X13_RS23285	COG0588	phosphoglycerate mutase activity
D3X13_RS23300	COG0477	Major facilitator Superfamily
D3X13_RS23325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D3X13_RS23335	COG0495	leucyl-tRNA aminoacylation
D3X13_RS23345	COG1307	EDD domain protein, DegV family
D3X13_RS23350	COG1555	photosystem II stabilization
D3X13_RS23355	COG1234	tRNA 3'-trailer cleavage
D3X13_RS23360	COG2353	YceI-like domain
D3X13_RS23375	COG0268	Binds directly to 16S ribosomal RNA
D3X13_RS23380	COG0481	GTPase activity
D3X13_RS23420	COG1420	regulation of RNA biosynthetic process
D3X13_RS23425	COG0484	heat shock protein binding
D3X13_RS23430	COG2070	2-Nitropropane dioxygenase
D3X13_RS23450	COG4946	Tricorn protease homolog
D3X13_RS23450	COG0793	Belongs to the peptidase S41A family
D3X13_RS23455	COG0537	adenosine 5'-monophosphoramidase activity
D3X13_RS23460	COG1234	tRNA 3'-trailer cleavage
D3X13_RS23465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3X13_RS23475	COG4948	Mandelate Racemase Muconate Lactonizing
D3X13_RS23480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3X13_RS23480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3X13_RS23490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3X13_RS23500	COG2315	Protein conserved in bacteria
D3X13_RS23530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3X13_RS23540	COG2723	6-phospho-beta-galactosidase activity
D3X13_RS23560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3X13_RS23570	COG2409	Drug exporters of the RND superfamily
D3X13_RS23575	COG4585	Histidine kinase
D3X13_RS23580	COG2197	response regulator
D3X13_RS23585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3X13_RS23590	COG4608	Belongs to the ABC transporter superfamily
D3X13_RS23595	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS23605	COG0747	negative chemotaxis
D3X13_RS23610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3X13_RS23660	COG1381	Involved in DNA repair and RecF pathway recombination
D3X13_RS23665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3X13_RS23675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3X13_RS23680	COG1121	(ABC) transporter
D3X13_RS23685	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3X13_RS23685	COG3443	Belongs to the bacterial solute-binding protein 9 family
D3X13_RS23690	COG0423	glycine-tRNA ligase activity
D3X13_RS23720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3X13_RS23720	COG0574	Belongs to the PEP-utilizing enzyme family
D3X13_RS23730	COG0395	ABC-type sugar transport system, permease component
D3X13_RS23735	COG1175	transmembrane transport
D3X13_RS23745	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS23750	COG1309	transcriptional regulator
D3X13_RS23760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3X13_RS23760	COG2146	nitrite reductase [NAD(P)H] activity
D3X13_RS23765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3X13_RS23810	COG0243	molybdopterin cofactor binding
D3X13_RS23815	COG2949	membrane
D3X13_RS23825	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3X13_RS23835	COG0358	DNA primase activity
D3X13_RS23840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3X13_RS23855	COG1070	Carbohydrate kinase
D3X13_RS23880	COG1295	ribonuclease BN
D3X13_RS23885	COG3585	molybdate ion transport
D3X13_RS23910	COG1077	Cell shape determining protein MreB Mrl
D3X13_RS23920	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS23925	COG0583	DNA-binding transcription factor activity
D3X13_RS23935	COG2855	membrane
D3X13_RS23975	COG4981	capsule polysaccharide biosynthetic process
D3X13_RS24015	COG2130	NADP-dependent
D3X13_RS24020	COG1764	response to oxidative stress
D3X13_RS24050	COG3226	Transcriptional regulator
D3X13_RS24055	COG0583	DNA-binding transcription factor activity
D3X13_RS24085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3X13_RS24090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3X13_RS24095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS24110	COG1741	Belongs to the pirin family
D3X13_RS24120	COG0789	Transcriptional regulator
D3X13_RS24125	COG0667	Aldo Keto reductase
D3X13_RS24140	COG2197	response regulator
D3X13_RS24145	COG4585	Histidine kinase
D3X13_RS24160	COG1309	transcriptional regulator
D3X13_RS24165	COG0477	Major facilitator Superfamily
D3X13_RS24175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D3X13_RS24220	COG1358	cellular component organization or biogenesis
D3X13_RS24235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS24240	COG0800	Aldolase
D3X13_RS24295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3X13_RS24310	COG0456	acetyltransferase
D3X13_RS24360	COG2124	cytochrome p450
D3X13_RS24365	COG0183	Belongs to the thiolase family
D3X13_RS24380	COG3845	ABC transporter
D3X13_RS24415	COG1309	transcriptional regulator
D3X13_RS24420	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS24445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS24455	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3X13_RS24470	COG0183	Belongs to the thiolase family
D3X13_RS24480	COG2197	response regulator
D3X13_RS24490	COG4585	Histidine kinase
D3X13_RS24495	COG2030	dehydratase
D3X13_RS24505	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS24520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3X13_RS24535	COG0800	Aldolase
D3X13_RS24540	COG3022	response to hydroperoxide
D3X13_RS24585	COG1674	ftsk spoiiie
D3X13_RS24690	COG2226	methyltransferase
D3X13_RS24700	COG2259	Doxx family
D3X13_RS24725	COG3540	Alkaline phosphatase
D3X13_RS24730	COG2814	Major facilitator Superfamily
D3X13_RS24735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3X13_RS24750	COG1834	amidinotransferase
D3X13_RS24805	COG1994	Peptidase M50
D3X13_RS24830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3X13_RS24835	COG0477	Major facilitator Superfamily
D3X13_RS24850	COG2814	Major facilitator Superfamily
D3X13_RS24855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3X13_RS24855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3X13_RS24865	COG2267	carboxylic ester hydrolase activity
D3X13_RS24880	COG1959	2 iron, 2 sulfur cluster binding
D3X13_RS24890	COG0174	glutamine synthetase
D3X13_RS24915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3X13_RS24925	COG1609	Transcriptional regulator
D3X13_RS24930	COG0366	Alpha amylase catalytic
D3X13_RS24980	COG2197	response regulator
D3X13_RS24985	COG4585	Histidine kinase
D3X13_RS25000	COG0745	RESPONSE REGULATOR receiver
D3X13_RS25020	COG2267	carboxylic ester hydrolase activity
D3X13_RS25040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS25045	COG1120	ATPase activity
D3X13_RS25080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3X13_RS25085	COG0321	lipoyl(octanoyl) transferase activity
D3X13_RS25130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D3X13_RS25140	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3X13_RS25145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3X13_RS25150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3X13_RS25155	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3X13_RS25170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3X13_RS25170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D3X13_RS25175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3X13_RS25195	COG4106	trans-aconitate 2-methyltransferase activity
D3X13_RS25215	COG4585	Histidine kinase
D3X13_RS25220	COG2197	response regulator
D3X13_RS25225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3X13_RS25230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3X13_RS25250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS25260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3X13_RS25265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3X13_RS25275	COG1376	ErfK ybiS ycfS ynhG family protein
D3X13_RS25285	COG1845	cytochrome c oxidase, subunit III
D3X13_RS25290	COG2010	Cytochrome c
D3X13_RS25295	COG0723	plastoquinol--plastocyanin reductase activity
D3X13_RS25300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3X13_RS25305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3X13_RS25310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3X13_RS25315	COG1929	Belongs to the glycerate kinase type-1 family
D3X13_RS25325	COG0745	RESPONSE REGULATOR receiver
D3X13_RS25330	COG2205	protein histidine kinase activity
D3X13_RS25360	COG0791	NLP P60 protein
D3X13_RS25400	COG0003	Pfam Anion-transporting ATPase
D3X13_RS25410	COG1940	carbohydrate kinase activity
D3X13_RS25435	COG4585	Histidine kinase
D3X13_RS25440	COG2197	response regulator
D3X13_RS25445	COG0205	6-phosphofructokinase activity
D3X13_RS25450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3X13_RS25475	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3X13_RS25480	COG0243	molybdopterin cofactor binding
D3X13_RS25485	COG2193	ferroxidase activity
D3X13_RS25490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3X13_RS25495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D3X13_RS25500	COG2815	serine threonine protein kinase
D3X13_RS25500	COG0515	serine threonine protein kinase
D3X13_RS25505	COG2022	thiamine diphosphate biosynthetic process
D3X13_RS25515	COG2022	thiamine diphosphate biosynthetic process
D3X13_RS25515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS25530	COG0352	thiamine-phosphate diphosphorylase activity
D3X13_RS25555	COG1309	transcriptional regulator
D3X13_RS25565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3X13_RS25585	COG0714	Associated with various cellular activities
D3X13_RS25595	COG0275	rRNA processing
D3X13_RS25605	COG0768	penicillin binding
D3X13_RS25610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3X13_RS25620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3X13_RS25625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3X13_RS25635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3X13_RS25640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3X13_RS25650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3X13_RS25655	COG1496	oxidoreductase activity
D3X13_RS25665	COG1799	cell septum assembly
D3X13_RS25675	COG3599	regulation of cell shape
D3X13_RS25680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3X13_RS25690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3X13_RS25740	COG0587	DNA-directed DNA polymerase activity
D3X13_RS25750	COG1432	Conserved Protein
D3X13_RS25770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3X13_RS25775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3X13_RS25790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3X13_RS25795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3X13_RS25800	COG0131	Imidazoleglycerol-phosphate dehydratase
D3X13_RS25805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3X13_RS25810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3X13_RS25815	COG0251	oxidation-reduction process
D3X13_RS25820	COG0107	imidazoleglycerol-phosphate synthase activity
D3X13_RS25830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3X13_RS25835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3X13_RS25855	COG0134	indole-3-glycerol-phosphate synthase activity
D3X13_RS25860	COG0133	tryptophan synthase activity
D3X13_RS25865	COG0159	tryptophan synthase activity
D3X13_RS25875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D3X13_RS25885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3X13_RS25890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS25920	COG0069	glutamate synthase activity
D3X13_RS25920	COG0070	glutamate synthase
D3X13_RS25920	COG0067	glutamate synthase
D3X13_RS25935	COG1175	transmembrane transport
D3X13_RS25940	COG0395	ABC-type sugar transport system, permease component
D3X13_RS25945	COG2304	oxidoreductase activity
D3X13_RS25955	COG1278	Cold shock
D3X13_RS25965	COG1357	PFAM Pentapeptide repeats (8 copies)
D3X13_RS25980	COG1470	cell adhesion involved in biofilm formation
D3X13_RS25980	COG0366	Alpha amylase catalytic
D3X13_RS25995	COG0287	Prephenate dehydrogenase
D3X13_RS25995	COG1605	Chorismate mutase
D3X13_RS26005	COG0702	epimerase
D3X13_RS26025	COG0737	Belongs to the 5'-nucleotidase family
D3X13_RS26090	COG2050	protein possibly involved in aromatic compounds catabolism
D3X13_RS26125	COG1643	Atp-dependent helicase
D3X13_RS26150	COG0237	dephospho-CoA kinase activity
D3X13_RS26165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3X13_RS26180	COG2267	carboxylic ester hydrolase activity
D3X13_RS26200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3X13_RS26230	COG0402	S-adenosylhomocysteine deaminase activity
D3X13_RS26290	COG0598	Magnesium transport protein CorA
D3X13_RS26305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3X13_RS26310	COG0584	glycerophosphoryl diester phosphodiesterase
D3X13_RS26320	COG0556	nucleotide-excision repair
D3X13_RS26340	COG0387	Pfam Sodium calcium exchanger
D3X13_RS26345	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3X13_RS26350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3X13_RS26365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3X13_RS26405	COG1660	Displays ATPase and GTPase activities
D3X13_RS26410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3X13_RS26415	COG1481	regulation of sporulation
D3X13_RS26425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3X13_RS26430	COG0126	phosphoglycerate kinase activity
D3X13_RS26435	COG0149	triose-phosphate isomerase activity
D3X13_RS26440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3X13_RS26450	COG0166	Belongs to the GPI family
D3X13_RS26460	COG0363	glucosamine-6-phosphate deaminase activity
D3X13_RS26475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3X13_RS26485	COG0109	protoheme IX farnesyltransferase activity
D3X13_RS26525	COG0719	Fe-S assembly protein
D3X13_RS26535	COG0396	ATPase activity
D3X13_RS26540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3X13_RS26545	COG0822	iron-sulfur transferase activity
D3X13_RS26560	COG3226	Transcriptional regulator
D3X13_RS26565	COG2171	N-acyltransferase activity
D3X13_RS26570	COG1595	DNA-templated transcription, initiation
D3X13_RS26580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3X13_RS26655	COG0395	ABC-type sugar transport system, permease component
D3X13_RS26670	COG1349	DNA-binding transcription factor activity
D3X13_RS26675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3X13_RS26680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3X13_RS26710	COG1695	Transcriptional regulator
D3X13_RS26720	COG0768	penicillin binding
D3X13_RS26725	COG2197	response regulator
D3X13_RS26730	COG4585	Histidine kinase
D3X13_RS26745	COG1414	Transcriptional regulator
D3X13_RS26765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3X13_RS26770	COG5285	phytanoyl-CoA dioxygenase
D3X13_RS26775	COG1917	Cupin 2, conserved barrel domain protein
D3X13_RS26780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3X13_RS26785	COG0456	acetyltransferase
D3X13_RS26790	COG2318	DinB family
D3X13_RS26795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D3X13_RS26820	COG1797	cobyrinic acid a,c-diamide synthase activity
D3X13_RS26835	COG1492	cobalamin metabolic process
D3X13_RS26840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3X13_RS26855	COG0235	Class ii aldolase
D3X13_RS26875	COG0488	(ABC) transporter
D3X13_RS26925	COG3387	PFAM Glycoside hydrolase 15-related
D3X13_RS26950	COG0326	Molecular chaperone. Has ATPase activity
D3X13_RS26995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3X13_RS27000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3X13_RS27020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3X13_RS27035	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS27040	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3X13_RS27050	COG2186	Transcriptional regulator
D3X13_RS27075	COG3830	Belongs to the UPF0237 family
D3X13_RS27075	COG0560	Phosphoserine phosphatase
D3X13_RS27085	COG1716	ATPase activity
D3X13_RS27085	COG1131	(ABC) transporter
D3X13_RS27085	COG0842	Transport permease protein
D3X13_RS27095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3X13_RS27100	COG4221	oxidoreductase activity
D3X13_RS27105	COG4585	Histidine kinase
D3X13_RS27110	COG2197	response regulator
D3X13_RS27130	COG1119	ATPase activity
D3X13_RS27150	COG1881	PFAM PEBP family protein
D3X13_RS27160	COG2094	Belongs to the DNA glycosylase MPG family
D3X13_RS27200	COG0647	UMP catabolic process
D3X13_RS27210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS27215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS27220	COG1120	ATPase activity
D3X13_RS27240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3X13_RS27250	COG0497	DNA recombination
D3X13_RS27255	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS27265	COG1309	transcriptional regulator
D3X13_RS27275	COG1902	pentaerythritol trinitrate reductase activity
D3X13_RS27280	COG3387	PFAM Glycoside hydrolase 15-related
D3X13_RS27285	COG0504	CTP synthase activity
D3X13_RS27290	COG0494	nUDIX hydrolase
D3X13_RS27300	COG0686	Belongs to the AlaDH PNT family
D3X13_RS27315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3X13_RS27320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3X13_RS27325	COG1187	pseudouridine synthase activity
D3X13_RS27350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3X13_RS27360	COG1160	GTP binding
D3X13_RS27390	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS27405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3X13_RS27415	COG0671	phosphoesterase, PA-phosphatase related
D3X13_RS27425	COG0477	Major facilitator Superfamily
D3X13_RS27430	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS27435	COG1799	cell septum assembly
D3X13_RS27465	COG0587	DNA-directed DNA polymerase activity
D3X13_RS27470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3X13_RS27485	COG4565	transcriptional regulatory protein
D3X13_RS27515	COG0454	-acetyltransferase
D3X13_RS27515	COG0456	acetyltransferase
D3X13_RS27520	COG1725	Transcriptional regulator
D3X13_RS27525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3X13_RS27540	COG0726	polysaccharide deacetylase
D3X13_RS27540	COG1649	PFAM Uncharacterised BCR, COG1649
D3X13_RS27550	COG0463	Glycosyl transferase, family 2
D3X13_RS27565	COG2755	lipolytic protein G-D-S-L family
D3X13_RS27570	COG0515	serine threonine protein kinase
D3X13_RS27600	COG2188	Transcriptional regulator
D3X13_RS27605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D3X13_RS27610	COG1309	transcriptional regulator
D3X13_RS27615	COG2851	Citrate transporter
D3X13_RS27650	COG0640	Transcriptional regulator
D3X13_RS27660	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS27680	COG0789	Transcriptional regulator
D3X13_RS27710	COG0477	Major facilitator Superfamily
D3X13_RS27730	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS27760	COG2149	membrane
D3X13_RS27765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D3X13_RS27775	COG3573	Dehydrogenase
D3X13_RS27795	COG3265	gluconokinase activity
D3X13_RS27805	COG3012	SEC-C Motif Domain Protein
D3X13_RS27820	COG0662	Cupin 2, conserved barrel domain protein
D3X13_RS27835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3X13_RS27840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3X13_RS27845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3X13_RS27855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3X13_RS27885	COG0667	Aldo Keto reductase
D3X13_RS27890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS27900	COG0598	Magnesium transport protein CorA
D3X13_RS27905	COG0406	alpha-ribazole phosphatase activity
D3X13_RS27920	COG0215	cysteine-tRNA ligase activity
D3X13_RS27930	COG2186	Transcriptional regulator
D3X13_RS27940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3X13_RS27945	COG0402	S-adenosylhomocysteine deaminase activity
D3X13_RS27955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3X13_RS27960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3X13_RS27965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3X13_RS27970	COG1414	Transcriptional regulator
D3X13_RS27975	COG0646	methionine synthase
D3X13_RS27975	COG1410	methionine synthase
D3X13_RS27985	COG0747	negative chemotaxis
D3X13_RS27990	COG2197	response regulator
D3X13_RS28000	COG0517	IMP dehydrogenase activity
D3X13_RS28000	COG1994	Peptidase M50
D3X13_RS28025	COG1222	aaa ATPase
D3X13_RS28030	COG4122	O-methyltransferase activity
D3X13_RS28045	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3X13_RS28050	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3X13_RS28055	COG1609	Transcriptional regulator
D3X13_RS28065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3X13_RS28070	COG0545	Peptidyl-prolyl cis-trans isomerase
D3X13_RS28080	COG2378	regulation of single-species biofilm formation
D3X13_RS28100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3X13_RS28105	COG0805	protein transport
D3X13_RS28160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3X13_RS28165	COG4175	Glycine betaine
D3X13_RS28165	COG0517	IMP dehydrogenase activity
D3X13_RS28205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3X13_RS28210	COG0531	amino acid
D3X13_RS28220	COG0174	glutamine synthetase
D3X13_RS28225	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS28235	COG0560	Phosphoserine phosphatase
D3X13_RS28235	COG3830	Belongs to the UPF0237 family
D3X13_RS28280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3X13_RS28285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3X13_RS28290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3X13_RS28295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3X13_RS28300	COG5002	protein histidine kinase activity
D3X13_RS28305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3X13_RS28310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3X13_RS28310	COG0072	phenylalanine-tRNA ligase activity
D3X13_RS28340	COG1649	PFAM Uncharacterised BCR, COG1649
D3X13_RS28350	COG0697	spore germination
D3X13_RS28365	COG0667	Aldo Keto reductase
D3X13_RS28370	COG0477	Major facilitator Superfamily
D3X13_RS28380	COG2838	Isocitrate dehydrogenase
D3X13_RS28400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3X13_RS28410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3X13_RS28415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3X13_RS28420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3X13_RS28425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3X13_RS28430	COG1438	arginine binding
D3X13_RS28435	COG0385	Bile acid
D3X13_RS28445	COG0165	Argininosuccinate lyase
D3X13_RS28460	COG0477	Major facilitator Superfamily
D3X13_RS28465	COG0204	Acyl-transferase
D3X13_RS28465	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS28470	COG0584	glycerophosphoryl diester phosphodiesterase
D3X13_RS28495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3X13_RS28500	COG2011	ABC-type metal ion transport system permease component
D3X13_RS28510	COG1464	Belongs to the NlpA lipoprotein family
D3X13_RS28525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3X13_RS28530	COG1648	precorrin-2 dehydrogenase activity
D3X13_RS28530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3X13_RS28590	COG0512	Glutamine amidotransferase of anthranilate synthase
D3X13_RS28590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3X13_RS28650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3X13_RS28665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3X13_RS28685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3X13_RS28690	COG1560	Kdo2-lipid A biosynthetic process
D3X13_RS28695	COG0438	transferase activity, transferring glycosyl groups
D3X13_RS28705	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D3X13_RS28710	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D3X13_RS28715	COG0217	transcriptional regulatory protein
D3X13_RS28720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3X13_RS28725	COG0632	four-way junction helicase activity
D3X13_RS28730	COG2255	four-way junction helicase activity
D3X13_RS28740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3X13_RS28745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3X13_RS28750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3X13_RS28755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3X13_RS28760	COG1196	nuclear chromosome segregation
D3X13_RS28775	COG0124	histidyl-tRNA synthetase
D3X13_RS28790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3X13_RS28810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3X13_RS28815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3X13_RS28825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3X13_RS28830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3X13_RS28835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3X13_RS28840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3X13_RS28845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3X13_RS28855	COG0006	proline dipeptidase activity
D3X13_RS28860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3X13_RS28865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3X13_RS28875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D3X13_RS28880	COG0540	Belongs to the ATCase OTCase family
D3X13_RS28885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3X13_RS28895	COG0505	Belongs to the CarA family
D3X13_RS28900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3X13_RS28905	COG0167	dihydroorotate dehydrogenase activity
D3X13_RS28910	COG0284	orotidine-5'-phosphate decarboxylase activity
D3X13_RS28920	COG0194	GDP metabolic process
D3X13_RS28935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3X13_RS28950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3X13_RS28960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3X13_RS28965	COG2390	Transcriptional regulator
D3X13_RS28980	COG0531	amino acid
D3X13_RS28995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3X13_RS29015	COG2233	PERMEase
D3X13_RS29020	COG0738	Major facilitator superfamily
D3X13_RS29025	COG1940	carbohydrate kinase activity
D3X13_RS29025	COG1846	Transcriptional regulator
D3X13_RS29045	COG3201	nicotinamide mononucleotide transporter
D3X13_RS29050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3X13_RS29050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3X13_RS29055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3X13_RS29060	COG0140	phosphoribosyl-ATP diphosphatase activity
D3X13_RS29065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D3X13_RS29115	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS29140	COG0463	Glycosyl transferase, family 2
D3X13_RS29155	COG2270	Major facilitator Superfamily
D3X13_RS29165	COG2364	Membrane
D3X13_RS29170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3X13_RS29195	COG1984	allophanate hydrolase subunit 2
D3X13_RS29200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3X13_RS29205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3X13_RS29210	COG4336	lyase activity
D3X13_RS29215	COG2814	Major facilitator Superfamily
D3X13_RS29245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS29260	COG1414	Transcriptional regulator
D3X13_RS29270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3X13_RS29300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3X13_RS29305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3X13_RS29310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3X13_RS29320	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3X13_RS29335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3X13_RS29345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3X13_RS29380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3X13_RS29400	COG1716	ATPase activity
D3X13_RS29420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3X13_RS29430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3X13_RS29430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3X13_RS29465	COG0384	phenazine biosynthesis protein PhzF
D3X13_RS29475	COG2890	protein-(glutamine-N5) methyltransferase activity
D3X13_RS29495	COG0697	spore germination
D3X13_RS29510	COG0697	spore germination
D3X13_RS29565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3X13_RS29590	COG0673	inositol 2-dehydrogenase activity
D3X13_RS29595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3X13_RS29615	COG4195	phage-related replication protein
D3X13_RS29620	COG1968	undecaprenyl-diphosphatase activity
D3X13_RS29635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3X13_RS29695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3X13_RS29720	COG0252	asparaginase activity
D3X13_RS29725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3X13_RS29760	COG3485	protocatechuate 3,4-dioxygenase
D3X13_RS29785	COG0531	amino acid
D3X13_RS29790	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS29795	COG1335	isochorismatase
D3X13_RS29810	COG2706	6-phosphogluconolactonase activity
D3X13_RS29825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3X13_RS29835	COG2040	homocysteine
D3X13_RS29845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS29860	COG1940	carbohydrate kinase activity
D3X13_RS29880	COG1902	pentaerythritol trinitrate reductase activity
D3X13_RS29905	COG1309	transcriptional regulator
D3X13_RS29915	COG0671	phosphoesterase, PA-phosphatase related
D3X13_RS29925	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D3X13_RS29945	COG1252	NADH dehydrogenase
D3X13_RS29960	COG0584	glycerophosphoryl diester phosphodiesterase
D3X13_RS29965	COG0671	phosphoesterase, PA-phosphatase related
D3X13_RS29975	COG0596	Alpha beta hydrolase
D3X13_RS29980	COG1597	lipid kinase activity
D3X13_RS29990	COG2376	Dihydroxyacetone kinase
D3X13_RS29995	COG1846	Transcriptional regulator
D3X13_RS29995	COG0456	acetyltransferase
D3X13_RS30020	COG1191	sigma factor activity
D3X13_RS30035	COG4044	May play a role in the intracellular transport of hydrophobic ligands
D3X13_RS30055	COG2172	sigma factor antagonist activity
D3X13_RS30060	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS30065	COG1366	Belongs to the anti-sigma-factor antagonist family
D3X13_RS30080	COG1191	sigma factor activity
D3X13_RS30110	COG0204	Acyl-transferase
D3X13_RS30130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3X13_RS30145	COG0515	serine threonine protein kinase
D3X13_RS30160	COG3345	alpha-galactosidase
D3X13_RS30180	COG1660	Displays ATPase and GTPase activities
D3X13_RS30190	COG0445	tRNA wobble uridine modification
D3X13_RS30210	COG1595	DNA-templated transcription, initiation
D3X13_RS30215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3X13_RS30225	COG1940	carbohydrate kinase activity
D3X13_RS30280	COG1349	DNA-binding transcription factor activity
D3X13_RS30315	COG1215	transferase activity, transferring glycosyl groups
D3X13_RS30320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3X13_RS30340	COG2813	Specifically methylates the guanine in position
D3X13_RS30345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D3X13_RS30350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3X13_RS30355	COG1902	pentaerythritol trinitrate reductase activity
D3X13_RS30355	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3X13_RS30390	COG1461	Dihydroxyacetone kinase
D3X13_RS30395	COG2376	Dihydroxyacetone kinase
D3X13_RS30425	COG1174	glycine betaine transport
D3X13_RS30430	COG1174	glycine betaine transport
D3X13_RS30445	COG1556	Lactate utilization protein
D3X13_RS30450	COG1139	Iron-sulfur cluster binding protein
D3X13_RS30455	COG0247	lactate metabolic process
D3X13_RS30490	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS30495	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS30505	COG0601	transmembrane transport
D3X13_RS30510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3X13_RS30515	COG0444	Belongs to the ABC transporter superfamily
D3X13_RS30560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3X13_RS30575	COG0019	diaminopimelate decarboxylase activity
D3X13_RS30605	COG2814	Major facilitator Superfamily
D3X13_RS30620	COG0659	secondary active sulfate transmembrane transporter activity
D3X13_RS30630	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS30660	COG0366	Alpha amylase catalytic
D3X13_RS30670	COG3281	Trehalose synthase
D3X13_RS30675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3X13_RS30695	COG1191	sigma factor activity
D3X13_RS30705	COG3433	isochorismatase activity
D3X13_RS30705	COG1535	isochorismatase
D3X13_RS30710	COG2375	cellular response to nickel ion
D3X13_RS30715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3X13_RS30720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS30725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS30730	COG1120	ATPase activity
D3X13_RS30780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3X13_RS30790	COG2197	response regulator
D3X13_RS30840	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS30860	COG1940	carbohydrate kinase activity
D3X13_RS30865	COG1070	Carbohydrate kinase
D3X13_RS30870	COG2115	Belongs to the xylose isomerase family
D3X13_RS30890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3X13_RS30895	COG3239	Fatty acid desaturase
D3X13_RS30945	COG2018	Roadblock/LC7 domain
D3X13_RS30950	COG1946	Acyl-CoA thioesterase
D3X13_RS30965	COG1132	(ABC) transporter
D3X13_RS30970	COG1132	(ABC) transporter
D3X13_RS30975	COG1132	(ABC) transporter
D3X13_RS30980	COG1132	(ABC) transporter
D3X13_RS31000	COG0277	FAD linked oxidase domain protein
D3X13_RS31005	COG1846	Transcriptional regulator
D3X13_RS31010	COG1132	(ABC) transporter
D3X13_RS31020	COG2318	DinB family
D3X13_RS31025	COG2072	flavoprotein involved in K transport
D3X13_RS31030	COG0432	Pfam Uncharacterised protein family UPF0047
D3X13_RS31045	COG1012	belongs to the aldehyde dehydrogenase family
D3X13_RS31065	COG2080	2 iron, 2 sulfur cluster binding
D3X13_RS31070	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3X13_RS31075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3X13_RS31080	COG3608	succinylglutamate desuccinylase aspartoacylase
D3X13_RS31080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3X13_RS31095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS31095	COG0723	plastoquinol--plastocyanin reductase activity
D3X13_RS31130	COG1832	CoA-binding protein
D3X13_RS31165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D3X13_RS31175	COG1739	Uncharacterized protein family UPF0029
D3X13_RS31180	COG0420	3'-5' exonuclease activity
D3X13_RS31185	COG0419	ATPase involved in DNA repair
D3X13_RS31200	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS31215	COG0626	cystathionine gamma-synthase activity
D3X13_RS31230	COG0346	lactoylglutathione lyase activity
D3X13_RS31240	COG1595	DNA-templated transcription, initiation
D3X13_RS31245	COG2188	Transcriptional regulator
D3X13_RS31250	COG1940	carbohydrate kinase activity
D3X13_RS31255	COG2197	response regulator
D3X13_RS31260	COG4585	Histidine kinase
D3X13_RS31280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3X13_RS31300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3X13_RS31325	COG1136	(ABC) transporter
D3X13_RS31325	COG0577	efflux transmembrane transporter activity
D3X13_RS31330	COG0577	efflux transmembrane transporter activity
D3X13_RS31330	COG1136	(ABC) transporter
D3X13_RS31345	COG2226	methyltransferase
D3X13_RS31350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3X13_RS31355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3X13_RS31360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3X13_RS31400	COG0740	serine-type endopeptidase activity
D3X13_RS31415	COG1309	transcriptional regulator
D3X13_RS31420	COG0831	urea catabolic process
D3X13_RS31425	COG0832	Belongs to the urease beta subunit family
D3X13_RS31430	COG0804	urea catabolic process
D3X13_RS31435	COG0830	nickel cation binding
D3X13_RS31440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3X13_RS31445	COG0829	nickel cation binding
D3X13_RS31455	COG0204	Acyl-transferase
D3X13_RS31470	COG0205	6-phosphofructokinase activity
D3X13_RS31475	COG3442	glutamine amidotransferase
D3X13_RS31485	COG0242	peptide deformylase activity
D3X13_RS31495	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS31520	COG2814	Major facilitator Superfamily
D3X13_RS31540	COG0367	asparagine synthase
D3X13_RS31555	COG0583	DNA-binding transcription factor activity
D3X13_RS31560	COG4941	Belongs to the sigma-70 factor family
D3X13_RS31585	COG2409	Drug exporters of the RND superfamily
D3X13_RS31600	COG2175	clavaminate synthase activity
D3X13_RS31610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3X13_RS31640	COG2226	methyltransferase
D3X13_RS31660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3X13_RS31665	COG2409	Drug exporters of the RND superfamily
D3X13_RS31670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3X13_RS31695	COG2755	lipolytic protein G-D-S-L family
D3X13_RS31710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3X13_RS31715	COG1309	transcriptional regulator
D3X13_RS31735	COG0739	heme binding
D3X13_RS31745	COG2340	Cysteine-rich secretory protein family
D3X13_RS31760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3X13_RS31790	COG1228	amidohydrolase
D3X13_RS31825	COG0693	protein deglycase activity
D3X13_RS31860	COG1295	ribonuclease BN
D3X13_RS31880	COG0009	L-threonylcarbamoyladenylate synthase
D3X13_RS31900	COG2318	DinB family
D3X13_RS31925	COG2207	Transcriptional regulator
D3X13_RS31925	COG3708	Transcriptional regulator
D3X13_RS31940	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D3X13_RS31960	COG0142	geranyltranstransferase activity
D3X13_RS31985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS32015	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
D3X13_RS32020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D3X13_RS32025	COG1122	ATPase activity
D3X13_RS32055	COG3896	Chloramphenicol phosphotransferase-like protein
D3X13_RS32110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D3X13_RS32115	COG1263	PTS System
D3X13_RS32115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3X13_RS32215	COG0789	Transcriptional regulator
D3X13_RS32225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D3X13_RS32240	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3X13_RS32250	COG3973	AAA domain
D3X13_RS32260	COG0475	glutathione-regulated potassium exporter activity
D3X13_RS32280	COG4106	trans-aconitate 2-methyltransferase activity
D3X13_RS32290	COG1295	ribonuclease BN
D3X13_RS32300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3X13_RS32305	COG1120	ATPase activity
D3X13_RS32310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D3X13_RS32335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3X13_RS32340	COG0395	ABC-type sugar transport system, permease component
D3X13_RS32360	COG1349	DNA-binding transcription factor activity
D3X13_RS32365	COG0784	Response regulator, receiver
D3X13_RS32370	COG4251	negative regulation of phosphorylation
D3X13_RS32380	COG0667	Aldo Keto reductase
D3X13_RS32420	COG1132	(ABC) transporter
D3X13_RS32440	COG0667	Aldo Keto reductase
D3X13_RS32445	COG4566	intracellular signal transduction
D3X13_RS32450	COG2124	cytochrome p450
D3X13_RS32500	COG0477	Major facilitator Superfamily
D3X13_RS32505	COG0513	Belongs to the DEAD box helicase family
D3X13_RS32525	COG0006	proline dipeptidase activity
D3X13_RS32600	COG3629	intracellular signal transduction
D3X13_RS32600	COG3903	Transcriptional regulator
D3X13_RS32605	COG0596	Alpha beta hydrolase
D3X13_RS32630	COG0488	(ABC) transporter
D3X13_RS32645	COG1554	hydrolase, family 65, central catalytic
D3X13_RS32675	COG0640	Transcriptional regulator
D3X13_RS32680	COG0346	lactoylglutathione lyase activity
D3X13_RS32700	COG1595	DNA-templated transcription, initiation
D3X13_RS32710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3X13_RS32745	COG0475	glutathione-regulated potassium exporter activity
D3X13_RS32760	COG4106	trans-aconitate 2-methyltransferase activity
D3X13_RS32770	COG2197	response regulator
D3X13_RS32810	COG3591	Belongs to the peptidase S1B family
D3X13_RS32830	COG2274	protein secretion by the type I secretion system
D3X13_RS32850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3X13_RS32925	COG1309	transcriptional regulator
D3X13_RS32950	COG1051	belongs to the nudix hydrolase family
D3X13_RS32970	COG2124	cytochrome p450
D3X13_RS33030	COG3629	intracellular signal transduction
D3X13_RS33035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS33040	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D3X13_RS33050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3X13_RS33050	COG0825	malonyl-CoA metabolic process
D3X13_RS33055	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS33065	COG2186	Transcriptional regulator
D3X13_RS33075	COG0583	DNA-binding transcription factor activity
D3X13_RS33170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS33175	COG1120	ATPase activity
D3X13_RS33180	COG1335	isochorismatase
D3X13_RS33185	COG0574	Belongs to the PEP-utilizing enzyme family
D3X13_RS33185	COG3848	Pyruvate phosphate dikinase
D3X13_RS33190	COG3903	Transcriptional regulator
D3X13_RS33190	COG3629	intracellular signal transduction
D3X13_RS33205	COG0110	maltose O-acetyltransferase activity
D3X13_RS33210	COG0488	(ABC) transporter
D3X13_RS33220	COG4733	cellulase activity
D3X13_RS33220	COG5297	Belongs to the glycosyl hydrolase family 6
D3X13_RS33235	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS33240	COG2072	flavoprotein involved in K transport
D3X13_RS33300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3X13_RS33330	COG2197	response regulator
D3X13_RS33365	COG2186	Transcriptional regulator
D3X13_RS33385	COG0596	Alpha beta hydrolase
D3X13_RS33400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3X13_RS33410	COG0154	amidase activity
D3X13_RS33435	COG0714	Associated with various cellular activities
D3X13_RS33460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3X13_RS33470	COG0798	PFAM Bile acid sodium symporter
D3X13_RS33475	COG2072	flavoprotein involved in K transport
D3X13_RS33480	COG0659	secondary active sulfate transmembrane transporter activity
D3X13_RS33485	COG0789	Transcriptional regulator
D3X13_RS33490	COG1595	DNA-templated transcription, initiation
D3X13_RS33515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3X13_RS33525	COG2226	methyltransferase
D3X13_RS33550	COG1472	Belongs to the glycosyl hydrolase 3 family
D3X13_RS33555	COG1609	Transcriptional regulator
D3X13_RS33570	COG0829	nickel cation binding
D3X13_RS33575	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3X13_RS33585	COG0804	urea catabolic process
D3X13_RS33590	COG0832	Belongs to the urease beta subunit family
D3X13_RS33590	COG0831	urea catabolic process
D3X13_RS33605	COG2391	methyltransferase activity
D3X13_RS33615	COG2050	protein possibly involved in aromatic compounds catabolism
D3X13_RS33630	COG2226	methyltransferase
D3X13_RS33640	COG0596	Alpha beta hydrolase
D3X13_RS33645	COG4552	Acetyltransferase involved in intracellular survival and related
D3X13_RS33650	COG2197	response regulator
D3X13_RS33660	COG0738	Major facilitator superfamily
D3X13_RS33670	COG3226	Transcriptional regulator
D3X13_RS33680	COG2318	DinB family
D3X13_RS33695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS33705	COG3483	tryptophan 2,3-dioxygenase activity
D3X13_RS33720	COG2130	NADP-dependent
D3X13_RS33815	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS33825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3X13_RS33875	COG0596	Alpha beta hydrolase
D3X13_RS33890	COG0640	Transcriptional regulator
D3X13_RS33915	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D3X13_RS33920	COG1960	acyl-CoA dehydrogenase activity
D3X13_RS33925	COG0318	PFAM AMP-dependent synthetase and ligase
D3X13_RS33930	COG1309	transcriptional regulator
D3X13_RS33960	COG0017	Asparaginyl-tRNA synthetase
D3X13_RS33985	COG2124	cytochrome p450
D3X13_RS34000	COG3977	Valine--pyruvate aminotransferase
D3X13_RS34030	COG3321	synthase
D3X13_RS34030	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS34030	COG0604	alcohol dehydrogenase
D3X13_RS34050	COG0076	glutamate decarboxylase activity
D3X13_RS34150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3X13_RS34155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3X13_RS34160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3X13_RS34165	COG1733	regulation of RNA biosynthetic process
D3X13_RS34200	COG4191	Histidine kinase
D3X13_RS34235	COG4585	Histidine kinase
D3X13_RS34240	COG2197	response regulator
D3X13_RS34295	COG0477	Major facilitator Superfamily
D3X13_RS34300	COG0402	S-adenosylhomocysteine deaminase activity
D3X13_RS34305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3X13_RS34310	COG1755	Isoprenylcysteine carboxyl methyltransferase
D3X13_RS34330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3X13_RS34340	COG0604	alcohol dehydrogenase
D3X13_RS34360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3X13_RS34365	COG0477	Major facilitator Superfamily
D3X13_RS34435	COG0531	amino acid
D3X13_RS34440	COG4977	sequence-specific DNA binding
D3X13_RS34450	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS34465	COG0402	S-adenosylhomocysteine deaminase activity
D3X13_RS34475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3X13_RS34480	COG0583	DNA-binding transcription factor activity
D3X13_RS34505	COG1335	isochorismatase
D3X13_RS34515	COG2205	protein histidine kinase activity
D3X13_RS34520	COG0745	RESPONSE REGULATOR receiver
D3X13_RS34530	COG1131	(ABC) transporter
D3X13_RS34535	COG1959	2 iron, 2 sulfur cluster binding
D3X13_RS34540	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS34550	COG0640	Transcriptional regulator
D3X13_RS34585	COG0789	Transcriptional regulator
D3X13_RS34615	COG1309	transcriptional regulator
D3X13_RS34655	COG0142	geranyltranstransferase activity
D3X13_RS34685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3X13_RS34715	COG2124	cytochrome p450
D3X13_RS34735	COG3251	PFAM MbtH domain protein
D3X13_RS34780	COG2205	protein histidine kinase activity
D3X13_RS34785	COG0745	RESPONSE REGULATOR receiver
D3X13_RS34795	COG1686	Belongs to the peptidase S11 family
D3X13_RS34800	COG1116	anion transmembrane transporter activity
D3X13_RS34815	COG0456	acetyltransferase
D3X13_RS34825	COG2814	Major facilitator Superfamily
D3X13_RS34885	COG0515	serine threonine protein kinase
D3X13_RS34885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3X13_RS34905	COG0583	DNA-binding transcription factor activity
D3X13_RS34920	COG0590	tRNA wobble adenosine to inosine editing
D3X13_RS34935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3X13_RS34950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3X13_RS35010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3X13_RS35015	COG0583	DNA-binding transcription factor activity
D3X13_RS35035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3X13_RS35105	COG4585	Histidine kinase
D3X13_RS35120	COG0596	Alpha beta hydrolase
D3X13_RS35125	COG2267	carboxylic ester hydrolase activity
D3X13_RS35130	COG3629	intracellular signal transduction
D3X13_RS35130	COG3903	Transcriptional regulator
D3X13_RS35145	COG0393	Putative heavy-metal-binding
D3X13_RS35190	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS35205	COG3693	PFAM glycoside hydrolase, family 10
D3X13_RS35265	COG0477	Major facilitator Superfamily
D3X13_RS35320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3X13_RS35340	COG5297	Belongs to the glycosyl hydrolase family 6
D3X13_RS35350	COG3397	chitin binding
D3X13_RS35390	COG0702	epimerase
D3X13_RS35420	COG0667	Aldo Keto reductase
D3X13_RS35425	COG1309	transcriptional regulator
D3X13_RS35460	COG1073	alpha beta
D3X13_RS35485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3X13_RS35485	COG2022	thiamine diphosphate biosynthetic process
D3X13_RS35495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3X13_RS35505	COG0277	FAD linked oxidase domain protein
D3X13_RS35535	COG0596	Alpha beta hydrolase
D3X13_RS35545	COG1309	transcriptional regulator
D3X13_RS35555	COG0667	Aldo Keto reductase
D3X13_RS35585	COG1028	Short-chain dehydrogenase reductase Sdr
D3X13_RS35590	COG1309	transcriptional regulator
D3X13_RS35600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3X13_RS35640	COG2124	cytochrome p450
D3X13_RS35645	COG0702	epimerase
D3X13_RS35685	COG2070	2-Nitropropane dioxygenase
D3X13_RS35705	COG0076	glutamate decarboxylase activity