locus-tag class description HUT09_RS00130 ENOG4105ECQ AraC Family Transcriptional Regulator HUT09_RS00210 ENOG4107T94 Endo-14-beta-xylanase HUT09_RS00230 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT09_RS00245 ENOG4105D2S major facilitator superfamily HUT09_RS00255 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HUT09_RS00280 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT09_RS00300 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT09_RS00380 ENOG4105BZU Histidine kinase HUT09_RS00395 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT09_RS00455 ENOG4108IG5 Transcriptional regulator HUT09_RS00460 ENOG4105EYF MMPL domain protein HUT09_RS00505 ENOG41065SU Two-component system sensor kinase HUT09_RS00510 ENOG4108KXV response regulator HUT09_RS00585 ENOG4105CR4 methylisocitrate lyase HUT09_RS00590 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_RS00600 ENOG4105K56 Transcriptional regulator HUT09_RS00605 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT09_RS00620 ENOG4105CHR reductase HUT09_RS00650 ENOG4105CQB FAD linked oxidase domain protein HUT09_RS00660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_RS00665 ENOG4105YVS arsR family transcriptional regulator HUT09_RS00670 ENOG4105DQ4 alcohol dehydrogenase HUT09_RS00695 ENOG41064MX Tetr family transcriptional regulator HUT09_RS00715 ENOG4105DHQ Histidine kinase HUT09_RS00745 ENOG4105CG3 alpha amylase, catalytic region HUT09_RS00750 ENOG4105DRS transport system, permease HUT09_RS00755 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT09_RS00760 ENOG4105XN3 extracellular solute-binding protein family 1 HUT09_RS00815 ENOG410804X Transcriptional regulator HUT09_RS00820 ENOG4105DE4 1-phosphofructokinase HUT09_RS00825 ENOG4105DM4 PTS System HUT09_RS00830 ENOG4107QYR Signal peptidase i HUT09_RS00895 ENOG4105NRA 50s ribosomal protein l31 type b HUT09_RS00930 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT09_RS00960 ENOG4105E39 Enoyl-CoA hydratase HUT09_RS00980 ENOG4105EAB amino acid AbC transporter HUT09_RS00985 ENOG4105E5Q amino acid AbC transporter HUT09_RS00995 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS01025 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS01035 ENOG4108A04 Beta-lactamase HUT09_RS01065 ENOG4105PDP Short chain dehydrogenase HUT09_RS01075 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT09_RS01080 ENOG4108UYE Lactoylglutathione lyase HUT09_RS01090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUT09_RS01095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS01110 ENOG4105C0W non-ribosomal peptide synthetase HUT09_RS01115 ENOG4105X7H acyl-CoA dehydrogenase HUT09_RS01120 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT09_RS01135 ENOG4108K8S endonuclease I HUT09_RS01140 ENOG4105CSV Glutaminase HUT09_RS01155 ENOG4108JQ1 Dehydrogenase HUT09_RS01160 ENOG4107QRI Phosphoketolase HUT09_RS01175 ENOG4105C7W Xanthine dehydrogenase HUT09_RS01180 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT09_RS01185 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT09_RS01245 ENOG4105M2Z protein tyrosine serine phosphatase HUT09_RS01270 ENOG4105E0A ABC, transporter HUT09_RS01275 ENOG4108MES Periplasmic binding protein HUT09_RS01285 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS01295 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT09_RS01300 ENOG4105E93 esterase HUT09_RS01305 ENOG4105TVJ transport system, permease HUT09_RS01310 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT09_RS01315 ENOG4105E4F Isochorismate synthase HUT09_RS01320 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT09_RS01325 ENOG4105WQI isochorismatase HUT09_RS01330 ENOG4105WQI isochorismatase HUT09_RS01345 ENOG4105C3U ABC transporter HUT09_RS01390 ENOG4105E2D ec 3.2.1.52 HUT09_RS01410 ENOG4107R9S Malate synthase HUT09_RS01445 ENOG4105BZ1 (ABC) transporter HUT09_RS01465 ENOG4108R5T secreted protein HUT09_RS01475 ENOG4105EGE secreted protein HUT09_RS01485 ENOG4105CPQ Dehydrogenase HUT09_RS01490 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT09_RS01535 ENOG4108YV4 Universal stress protein HUT09_RS01545 ENOG4105E93 esterase HUT09_RS01550 ENOG4105BZ1 (ABC) transporter HUT09_RS01560 ENOG4105BZ1 (ABC) transporter HUT09_RS01565 ENOG4108HUF Transporter HUT09_RS01570 ENOG4105E0A ABC, transporter HUT09_RS01575 ENOG4105TVJ transport system, permease HUT09_RS01580 ENOG4105DQ5 transport system permease protein HUT09_RS01615 ENOG4105F4R Transcriptional regulator mode HUT09_RS01635 ENOG41082YX Transcriptional regulator, arsr family HUT09_RS01670 ENOG4105BZ1 (ABC) transporter HUT09_RS01695 ENOG4105CPF Cell wall formation (By similarity) HUT09_RS01715 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT09_RS01720 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT09_RS01725 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_RS01735 ENOG41085FC arsR family transcriptional regulator HUT09_RS01740 ENOG4108J2R molybdopterin oxidoreductase HUT09_RS01760 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS01765 ENOG4105C8U phosphate abc transporter HUT09_RS01770 ENOG4105CVA phosphate HUT09_RS01790 ENOG41082YX Transcriptional regulator, arsr family HUT09_RS01805 ENOG4105H3G oxidoreductase HUT09_RS01820 ENOG4105HS2 Arsenate reductase HUT09_RS01825 ENOG4105CMT Dihydroxyacetone kinase HUT09_RS01830 ENOG4108UTZ Dihydroxyacetone kinase HUT09_RS01875 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS01885 ENOG4105DWV Homoserine O-trans-acetylase HUT09_RS01905 ENOG4105E0A ABC, transporter HUT09_RS01910 ENOG4105EHG Permease protein HUT09_RS01945 ENOG4105D7K pfkb domain protein HUT09_RS01985 ENOG4107S2Z UPF0761 membrane protein HUT09_RS02005 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS02010 ENOG41065KQ synthase HUT09_RS02020 ENOG4105E0A ABC, transporter HUT09_RS02025 ENOG4105TVJ transport system, permease HUT09_RS02030 ENOG4105DQ5 transport system permease protein HUT09_RS02050 ENOG41067SE Tetr family transcriptional regulator HUT09_RS02075 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT09_RS02085 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT09_RS02090 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS02095 ENOG4105CNN ABC, transporter HUT09_RS02100 ENOG4107R9N ABC transporter HUT09_RS02105 ENOG4105C2J ABC transporter HUT09_RS02110 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT09_RS02140 ENOG4105IDI abc transporter atp-binding protein HUT09_RS02190 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT09_RS02195 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUT09_RS02205 ENOG4105BZ1 (ABC) transporter HUT09_RS02215 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT09_RS02225 ENOG4105EQD regulatoR HUT09_RS02230 ENOG4105DQ5 transport system permease protein HUT09_RS02235 ENOG4108U1V ABC transporter, permease HUT09_RS02240 ENOG4105E0A ABC, transporter HUT09_RS02280 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_RS02285 ENOG4105CSH Transporter HUT09_RS02335 ENOG4106F1P AAA ATPase, central domain protein HUT09_RS02345 ENOG4105MVE transcriptional regulator HUT09_RS02360 ENOG4105CGD Nad-dependent epimerase dehydratase HUT09_RS02370 ENOG4105C6T cysteine synthase HUT09_RS02385 ENOG4105DKQ ROK family HUT09_RS02390 ENOG4106UW1 Major Facilitator superfamily HUT09_RS02420 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUT09_RS02425 ENOG4107PP3 Acetylornithine deacetylase HUT09_RS02435 ENOG4105I1F Resistance protein HUT09_RS02460 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT09_RS02465 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT09_RS02470 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT09_RS02490 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HUT09_RS02495 ENOG4105CMT Dihydroxyacetone kinase HUT09_RS02500 ENOG4105CMT Dihydroxyacetone kinase HUT09_RS02505 ENOG4105C0X amino acid HUT09_RS02515 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT09_RS02520 ENOG41060NJ transcriptional regulator HUT09_RS02545 ENOG4105C10 Electron transfer flavoprotein HUT09_RS02590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT09_RS02595 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_RS02610 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT09_RS02635 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUT09_RS02660 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT09_RS02675 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT09_RS02690 ENOG4107VXZ Hydrolase HUT09_RS02695 ENOG4105D9P serine threonine protein kinase HUT09_RS02700 ENOG4107SET aldo keto reductase HUT09_RS02705 ENOG4106UDK Cellulose-binding, family II HUT09_RS02715 ENOG4105DQE DNA ligase HUT09_RS02740 ENOG4105C37 (CBS) domain HUT09_RS02775 ENOG4108Z86 Glutamine amidotransferase HUT09_RS02780 ENOG4105CUB amino acid HUT09_RS02785 ENOG41073TP transcriptional regulator HUT09_RS02790 ENOG4105C5F glutamine synthetase HUT09_RS02795 ENOG4105C26 Dehydrogenase HUT09_RS02830 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUT09_RS02850 ENOG4105W49 UPF0434 protein HUT09_RS02865 ENOG4108WYP Transcriptional regulator HUT09_RS02875 ENOG4105DZC cytosine deaminase HUT09_RS02890 ENOG4105DQ5 transport system permease protein HUT09_RS02895 ENOG4105TVJ transport system, permease HUT09_RS02900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS02905 ENOG4105BZ1 (ABC) transporter HUT09_RS02920 ENOG4107R72 Ceramidase HUT09_RS02940 ENOG4105DDN Pentapeptide repeat-containing protein HUT09_RS02950 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HUT09_RS02975 ENOG4107XGZ Hydrolase HUT09_RS03015 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS03040 ENOG4105F76 Sarcosine oxidase HUT09_RS03055 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT09_RS03060 ENOG4105TVJ transport system, permease HUT09_RS03065 ENOG4105DQ5 transport system permease protein HUT09_RS03075 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HUT09_RS03110 ENOG4105DXX methyltransferase HUT09_RS03115 ENOG4105NGS secreted protein HUT09_RS03135 ENOG4105DWY Agmatine deiminase HUT09_RS03145 ENOG4105C3U ABC transporter HUT09_RS03150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS03160 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_RS03165 ENOG4105DWY Agmatine deiminase HUT09_RS03170 ENOG4105CQM Urea amidohydrolase subunit alpha HUT09_RS03185 ENOG4107TPY serine threonine protein kinase HUT09_RS03195 ENOG4105DWY Agmatine deiminase HUT09_RS03220 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS03225 ENOG4107ZED Uncharacterised protein family UPF0047 HUT09_RS03230 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_RS03235 ENOG4105E2Y ABC, transporter HUT09_RS03245 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT09_RS03250 ENOG4105H3G oxidoreductase HUT09_RS03265 ENOG4105BZ1 (ABC) transporter HUT09_RS03270 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT09_RS03275 ENOG4105CQB FAD linked oxidase domain protein HUT09_RS03280 ENOG4105EPC oxidoreductase HUT09_RS03285 ENOG4105BZ1 (ABC) transporter HUT09_RS03290 ENOG4105BZ1 (ABC) transporter HUT09_RS03315 ENOG4105CEP NADH dehydrogenase HUT09_RS03320 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUT09_RS03335 ENOG4105C29 acyl-CoA thioesterase HUT09_RS03345 ENOG4105BZP glycoside hydrolase 15-related HUT09_RS03360 ENOG4105VCT ion-transport protein YfeO HUT09_RS03370 ENOG4108V06 Glutathione peroxidase HUT09_RS03375 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS03385 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT09_RS03395 ENOG4105F1K Glutamine amidotransferase HUT09_RS03400 ENOG4105CTQ phosphohexokinase HUT09_RS03415 ENOG4105F6E Acyl-transferase HUT09_RS03435 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT09_RS03445 ENOG4105CQM Urea amidohydrolase subunit alpha HUT09_RS03450 ENOG4105KI2 Urea amidohydrolase subunit beta HUT09_RS03455 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUT09_RS03460 ENOG4108Q5F Tetr family transcriptional regulator HUT09_RS03490 ENOG4107SN7 NLP P60 protein HUT09_RS03495 ENOG4105N14 lysine exporter protein LysE YggA HUT09_RS03500 ENOG4108M0I Transcriptional regulator HUT09_RS03525 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT09_RS03530 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT09_RS03535 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT09_RS03810 ENOG4105C83 adenylosuccinate lyase HUT09_RS03815 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT09_RS03825 ENOG4105DKQ ROK family HUT09_RS03830 ENOG4105FDP GntR family transcriptional regulator HUT09_RS03835 ENOG4108KPJ rna polymerase sigma factor HUT09_RS03840 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT09_RS03850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT09_RS03905 ENOG4105EYH Exonuclease HUT09_RS03915 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT09_RS03920 ENOG4105K4P CoA-binding domain protein HUT09_RS03945 ENOG4108Z0R Transferase HUT09_RS03960 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT09_RS03965 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT09_RS03985 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT09_RS04040 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HUT09_RS04045 ENOG4105EP9 oxidoreductase HUT09_RS04065 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT09_RS04075 ENOG4105CHR reductase HUT09_RS04095 ENOG4105C3M thioredoxin reductase HUT09_RS04100 ENOG4105CUX Signal transduction histidine kinase HUT09_RS04125 ENOG4105JQN Transcriptional regulator HUT09_RS04130 ENOG4108Q5Y Membrane HUT09_RS04135 ENOG4105CSW GntR family transcriptional regulator HUT09_RS04215 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT09_RS04245 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT09_RS04255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT09_RS04275 ENOG4108UW8 fha domain-containing protein HUT09_RS04325 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT09_RS04335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT09_RS04350 ENOG4108UQS dipeptidase HUT09_RS04380 ENOG4105GWZ Roadblock lc7 family protein HUT09_RS04425 ENOG4105JXB ankyrin repeat-containing protein HUT09_RS04445 ENOG4108VW9 Membrane HUT09_RS04455 ENOG4105DEU major facilitator superfamily HUT09_RS04460 ENOG4105Q70 HUT09_RS04465 ENOG4105FS0 cytoplasmic membrane protein HUT09_RS04470 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT09_RS04480 ENOG4105EW9 transcriptional regulator AsnC family HUT09_RS04490 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS04545 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT09_RS04550 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT09_RS04555 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT09_RS04560 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT09_RS04600 ENOG4105C2W permease HUT09_RS04630 ENOG4105C26 Dehydrogenase HUT09_RS04645 ENOG4105DKT Transcriptional regulator HUT09_RS04650 ENOG4105DJV ribulose-phosphate 3-epimerase HUT09_RS04660 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT09_RS04675 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT09_RS04685 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT09_RS04700 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT09_RS04705 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT09_RS04710 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT09_RS04715 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT09_RS04725 ENOG4105CD3 dihydroorotase HUT09_RS04730 ENOG4105CXT aspartate transcarbamylase HUT09_RS04735 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT09_RS04745 ENOG410803B Involved in the transcription termination process (By similarity) HUT09_RS04750 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT09_RS04755 ENOG4105DC7 peptidase M24 HUT09_RS04765 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT09_RS04770 ENOG4105D49 3-dehydroquinate synthase HUT09_RS04775 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT09_RS04780 ENOG4105E2X shikimate dehydrogenase HUT09_RS04790 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT09_RS04795 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT09_RS04815 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT09_RS04835 ENOG4105CUT histidyl-tRNA synthetase HUT09_RS04850 ENOG4105C99 atpase involved in dna repair HUT09_RS04855 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT09_RS04860 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT09_RS04865 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT09_RS04870 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT09_RS04880 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT09_RS04885 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT09_RS04890 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT09_RS04895 ENOG4105CDY transcriptional regulatory protein HUT09_RS04900 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT09_RS04905 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT09_RS04915 ENOG4105E2K Glycosyl transferase (Group 1 HUT09_RS04920 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT09_RS04950 ENOG4105C22 threonyL-tRNA synthetase HUT09_RS04965 ENOG4108IRC dna polymerase iii HUT09_RS04990 ENOG4105KF0 sporulation and cell division protein, SsgA HUT09_RS05025 ENOG4105CRQ synthase (Component I) HUT09_RS05080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT09_RS05085 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT09_RS05100 ENOG4105D01 (LipO)protein HUT09_RS05105 ENOG4108UMI ABC transporter, permease HUT09_RS05110 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS05145 ENOG4105C57 major facilitator superfamily HUT09_RS05150 ENOG4105RJZ Transcriptional regulator HUT09_RS05160 ENOG4105EEM helicase HUT09_RS05170 ENOG4105CH7 arginosuccinase HUT09_RS05175 ENOG4105CDH Citrulline--aspartate ligase HUT09_RS05195 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT09_RS05200 ENOG4105C8Y Acetylornithine aminotransferase HUT09_RS05205 ENOG4105CAS nag kinase HUT09_RS05210 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT09_RS05215 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT09_RS05225 ENOG4105C09 Bile acid HUT09_RS05275 ENOG4105T38 integral membrane protein HUT09_RS05285 ENOG4105F32 YngK protein HUT09_RS05305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT09_RS05310 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT09_RS05315 ENOG4105BZU Histidine kinase HUT09_RS05320 ENOG4108RWN rrna methyltransferase HUT09_RS05325 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT09_RS05330 ENOG41084BS 50S ribosomal protein L35 HUT09_RS05335 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUT09_RS05395 ENOG4108IJ7 Glycine betaine HUT09_RS05400 ENOG4105HFS 5'-3' exonuclease HUT09_RS05425 ENOG4105K6V RNA polymerase HUT09_RS05430 ENOG4105RNG membrane HUT09_RS05435 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT09_RS05445 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT09_RS05450 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT09_RS05490 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUT09_RS05495 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT09_RS05515 ENOG4108FFZ Transcriptional regulator HUT09_RS05525 ENOG4108V1T peptidylprolyl cis-trans isomerase HUT09_RS05530 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT09_RS05540 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS05545 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT09_RS05550 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT09_RS05560 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT09_RS05565 ENOG4105E5F proteasome HUT09_RS05570 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT09_RS05600 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS05605 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT09_RS05615 ENOG4105C3R Methionine synthase HUT09_RS05620 ENOG4108K8U Glycerol operon regulatory protein HUT09_RS05625 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT09_RS05630 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT09_RS05635 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT09_RS05640 ENOG4105DEN Luciferase family HUT09_RS05655 ENOG4105C8N cysteinyl-tRNA synthetase HUT09_RS05675 ENOG4105D7N magnesium and cobalt transport protein CorA HUT09_RS05685 ENOG4105DYW oxidoreductase HUT09_RS05690 ENOG4105CPC Aldo Keto reductase HUT09_RS05720 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT09_RS05730 ENOG4105D3G Pseudouridine synthase HUT09_RS05745 ENOG4105C6F GntR Family Transcriptional Regulator HUT09_RS05750 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT09_RS05755 ENOG4105C6Z Gluconate HUT09_RS05775 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HUT09_RS05780 ENOG4105PTV Nudix Hydrolase HUT09_RS05785 ENOG4105VG5 Membrane HUT09_RS05795 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT09_RS05800 ENOG4105EQX glucarate dehydratase HUT09_RS05810 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS05815 ENOG4105IIU Aminopeptidase HUT09_RS05820 ENOG4108IG5 Transcriptional regulator HUT09_RS05825 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS05835 ENOG4105EHZ conserved protein UCP016719 HUT09_RS05855 ENOG4108Z4X TRANSCRIPTIONal HUT09_RS05865 ENOG4108IV0 ABC, transporter HUT09_RS05870 ENOG4105C0Z ABC transporter HUT09_RS05880 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_RS05885 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HUT09_RS05910 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS05920 ENOG4107Y9U Membrane HUT09_RS05925 ENOG4105CSR polyphosphate kinase 2 HUT09_RS05940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS05950 ENOG4105D4T Citrate transporter HUT09_RS05955 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_RS05960 ENOG4108SGK Tetr family transcriptional regulator HUT09_RS05965 ENOG4105F1J Homogentisate 1,2-dioxygenase HUT09_RS05990 ENOG4108TCJ secreted hydrolase HUT09_RS06000 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT09_RS06015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT09_RS06035 ENOG4106YYS transcriptional regulatory protein HUT09_RS06040 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_RS06065 ENOG4107IFA Lipase (EC 3.1.1.3) HUT09_RS06070 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT09_RS06075 ENOG4105C0B DNA polymerase III (alpha subunit) HUT09_RS06135 ENOG4106NMR serine protease HUT09_RS06155 ENOG4105EAB amino acid AbC transporter HUT09_RS06175 ENOG4105E5Q amino acid AbC transporter HUT09_RS06180 ENOG4105EAB amino acid AbC transporter HUT09_RS06190 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT09_RS06195 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS06200 ENOG4105C57 major facilitator superfamily HUT09_RS06205 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT09_RS06220 ENOG4105CPK Glycosyl transferase (Group 1 HUT09_RS06235 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT09_RS06245 ENOG4105CAT Cytidine monophosphate kinase HUT09_RS06285 ENOG410756H nucleotidyltransferase HUT09_RS06310 ENOG4105FE9 pseudouridine synthase HUT09_RS06315 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT09_RS06320 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUT09_RS06335 ENOG4105DCF alanine dehydrogenase HUT09_RS06350 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT09_RS06355 ENOG4105BZP glycoside hydrolase 15-related HUT09_RS06370 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HUT09_RS06375 ENOG4105CBG Sulfatase HUT09_RS06380 ENOG4105E6M Sulphatase-modifying factor protein HUT09_RS06390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS06430 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT09_RS06435 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT09_RS06455 ENOG4105E0A ABC, transporter HUT09_RS06460 ENOG4105DSU hydrolase HUT09_RS06490 ENOG4108VX5 3-methyladenine DNA glycosylase HUT09_RS06500 ENOG4108V1U phospholipid-binding protein HUT09_RS06525 ENOG4105DKW ABC transporter HUT09_RS06540 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS06545 ENOG4108XG2 Histidine kinase HUT09_RS06555 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUT09_RS06565 ENOG4105IDI abc transporter atp-binding protein HUT09_RS06570 ENOG4105EAC phosphoserine phosphatase HUT09_RS06590 ENOG4107YCY Transcriptional regulator HUT09_RS06600 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT09_RS06605 ENOG4105CHR reductase HUT09_RS06620 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT09_RS06640 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT09_RS06645 ENOG4107QN1 sodium solute HUT09_RS06660 ENOG4105E2A Dehydrogenase HUT09_RS06695 ENOG4105BZP glycoside hydrolase 15-related HUT09_RS06725 ENOG4105VBF alkaline shock protein HUT09_RS06735 ENOG4106YT9 Enoyl-CoA hydratase HUT09_RS06745 ENOG4105C5H ABC transporter HUT09_RS06770 ENOG4107W7X Aldolase HUT09_RS06785 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT09_RS06790 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT09_RS06805 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT09_RS06830 ENOG4105C3J Cysteine desulfurase HUT09_RS06860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_RS06865 ENOG41067TZ transcriptional regulator, MarR family HUT09_RS06890 ENOG4107HP6 Transcriptional regulator HUT09_RS06905 ENOG4105BZU Histidine kinase HUT09_RS06910 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS06915 ENOG4105CJN penicillin-binding protein HUT09_RS06920 ENOG4105C7N Xanthine uracil vitamin C permease HUT09_RS06935 ENOG4105FBW Monooxygenase HUT09_RS06955 ENOG4105FBW Monooxygenase HUT09_RS06960 ENOG4105C5Q Transcriptional regulator HUT09_RS06995 ENOG4108762 serine threonine protein kinase HUT09_RS07000 ENOG4108762 serine threonine protein kinase HUT09_RS07020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT09_RS07025 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT09_RS07030 ENOG4108RFG Tetr family transcriptional regulator HUT09_RS07050 ENOG4105VG1 fes assembly suf system protein HUT09_RS07055 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT09_RS07060 ENOG4105C9B Cysteine desulfurase HUT09_RS07065 ENOG4105C3K feS assembly ATPase SufC HUT09_RS07075 ENOG4105JRK feS assembly protein SufD HUT09_RS07090 ENOG4105CJ1 ABC, transporter HUT09_RS07110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT09_RS07120 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT09_RS07135 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT09_RS07145 ENOG4105K7W phage-related replication protein HUT09_RS07160 ENOG4107QP8 phosphohexose isomerase HUT09_RS07175 ENOG4105CP7 Triose-phosphate isomerase HUT09_RS07180 ENOG4105BZA Phosphoglycerate kinase HUT09_RS07185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT09_RS07190 ENOG4105CIE May be required for sporulation (By similarity) HUT09_RS07195 ENOG4105CHW UPF0052 protein HUT09_RS07200 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT09_RS07205 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT09_RS07230 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT09_RS07260 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT09_RS07270 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT09_RS07275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT09_RS07285 ENOG4108HH4 Major Facilitator Superfamily HUT09_RS07295 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT09_RS07315 ENOG4105CHM Aminotransferase HUT09_RS07335 ENOG4105C0D helicase HUT09_RS07355 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT09_RS07375 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_RS07380 ENOG4105CQ7 ATP-dependent helicase HUT09_RS07415 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUT09_RS07425 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_RS07430 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT09_RS07435 ENOG4105C0Z ABC transporter HUT09_RS07440 ENOG4108IV0 ABC, transporter HUT09_RS07470 ENOG4105CGH 5'-nucleotidase HUT09_RS07490 ENOG4105CHH sulfate transporter HUT09_RS07500 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HUT09_RS07515 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT09_RS07520 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HUT09_RS07535 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT09_RS07555 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT09_RS07560 ENOG41060WC Enoyl-CoA hydratase HUT09_RS07575 ENOG4105EA8 2-Nitropropane dioxygenase HUT09_RS07580 ENOG4105C1J atp-dependent rna helicase HUT09_RS07585 ENOG4105VEQ Cold shock protein HUT09_RS07590 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS07595 ENOG4108RZE Tetr family transcriptional regulator HUT09_RS07600 ENOG4105CHR reductase HUT09_RS07605 ENOG4105CC9 acyl-Coa dehydrogenase HUT09_RS07610 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS07620 ENOG41090B9 response to stress HUT09_RS07625 ENOG4105MUA Resistance protein HUT09_RS07640 ENOG4105CBC glutamate synthase HUT09_RS07650 ENOG41065RQ ADP-ribosylation crystallin J1 HUT09_RS07670 ENOG4108RVA ribokinase HUT09_RS07675 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT09_RS07685 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT09_RS07695 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT09_RS07700 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT09_RS07710 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT09_RS07730 ENOG4105CRQ synthase (Component I) HUT09_RS07735 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT09_RS07745 ENOG4105G9B Transcriptional regulator HUT09_RS07760 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT09_RS07765 ENOG4108176 endoribonuclease L-psp HUT09_RS07770 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT09_RS07775 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT09_RS07785 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT09_RS07790 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT09_RS07795 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT09_RS07815 ENOG4108Z66 YbaK ebsC protein HUT09_RS07845 ENOG4105C0B DNA polymerase III (alpha subunit) HUT09_RS07895 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT09_RS07905 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT09_RS07910 ENOG4107VQS DivIVA family HUT09_RS07920 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT09_RS07925 ENOG4105DFA alanine racemase domain protein HUT09_RS07930 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUT09_RS07935 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT09_RS07940 ENOG4105ME9 cell division protein FtsQ HUT09_RS07945 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT09_RS07955 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT09_RS07960 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT09_RS07970 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT09_RS07975 ENOG4105CJN penicillin-binding protein HUT09_RS07985 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT09_RS07995 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT09_RS08015 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT09_RS08025 ENOG4107T0D ABC, transporter HUT09_RS08030 ENOG4105ECB domain protein HUT09_RS08045 ENOG4105EWK phytoene HUT09_RS08060 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT09_RS08090 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT09_RS08100 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT09_RS08110 ENOG4108UQY Iron-storage protein HUT09_RS08120 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT09_RS08135 ENOG4105C5I Dehydrogenase HUT09_RS08145 ENOG4105ENE Histidine kinase HUT09_RS08170 ENOG4105DKQ ROK family HUT09_RS08180 ENOG4105D0U Arsenite-activated ATPase (ArsA) HUT09_RS08250 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT09_RS08255 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT09_RS08260 ENOG4107EUI c reductase, iron-sulfur HUT09_RS08265 ENOG4107UDY cytochrome C HUT09_RS08270 ENOG4105CCU oxidase (Subunit III) HUT09_RS08280 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT09_RS08285 ENOG4105MCD Part of cytochrome c oxidase, its function is HUT09_RS08290 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT09_RS08295 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT09_RS08300 ENOG4107QI6 Cysteine desulfurase HUT09_RS08305 ENOG4107T4Z adenosine kinase HUT09_RS08325 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT09_RS08340 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS08345 ENOG4105BZU Histidine kinase HUT09_RS08365 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_RS08370 ENOG4105C0H protease HUT09_RS08380 ENOG4108YZT Adenosylcobinamide kinase HUT09_RS08385 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT09_RS08390 ENOG4105CRK lysyL-tRNA synthetase HUT09_RS08410 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT09_RS08430 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT09_RS08450 ENOG4105ECP epimerase HUT09_RS08465 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT09_RS08470 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT09_RS08500 ENOG4105UA4 acetyltransferase HUT09_RS08515 ENOG4108222 arsenate reductase HUT09_RS08520 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_RS08525 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT09_RS08545 ENOG4107R5B glutamine synthetase HUT09_RS08550 ENOG4107NHD transcriptional regulator HUT09_RS08555 ENOG4107R13 MMPL domain protein HUT09_RS08560 ENOG4108XG2 Histidine kinase HUT09_RS08565 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS08625 ENOG4105CG3 alpha amylase, catalytic region HUT09_RS08630 ENOG4105EG2 ABC transporter, permease HUT09_RS08645 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS08660 ENOG4105CUB amino acid HUT09_RS08670 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT09_RS08680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_RS08690 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT09_RS08720 ENOG4105C5F glutamine synthetase HUT09_RS08745 ENOG4107R16 Multicopper oxidase HUT09_RS08750 ENOG4105C4K Nad synthetase HUT09_RS08755 ENOG4105F27 Major Facilitator HUT09_RS08770 ENOG4105C57 major facilitator superfamily HUT09_RS08775 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT09_RS08795 ENOG4107XZ0 Peptidase M50 HUT09_RS08840 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT09_RS08855 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT09_RS08860 ENOG4105EHG Permease protein HUT09_RS08865 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS08870 ENOG4106A0S HUT09_RS08885 ENOG4105CIK Amidinotransferase HUT09_RS08900 ENOG4105C2C drug resistance transporter, Bcr CflA HUT09_RS08910 ENOG4105DGI Alkaline phosphatase HUT09_RS08925 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT09_RS08955 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_RS08985 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUT09_RS08990 ENOG4107XFJ UPF0246 protein HUT09_RS08995 ENOG4108UHU Aldolase HUT09_RS09015 ENOG4105EGD dinuclear metal center protein, YbgI family HUT09_RS09035 ENOG4105CHR reductase HUT09_RS09055 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS09060 ENOG4105D2B acyl-CoA dehydrogenase HUT09_RS09065 ENOG4107QZF nitrite reductase NADPH large subunit HUT09_RS09070 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUT09_RS09075 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_RS09080 ENOG4107QND Nitrite extrusion protein HUT09_RS09105 ENOG4105DYW oxidoreductase HUT09_RS09130 ENOG4107QVI Methyltransferase, type 11 HUT09_RS09135 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_RS09140 ENOG4108SGK Tetr family transcriptional regulator HUT09_RS09210 ENOG4105BZ1 (ABC) transporter HUT09_RS09220 ENOG4105F2C Acetyl-CoA acetyltransferase HUT09_RS09225 ENOG4106A3M Cytochrome p-450 HUT09_RS09260 ENOG4105C4B ABC transporter, permease HUT09_RS09275 ENOG4105NQG DoxX HUT09_RS09355 ENOG4105DAX Pfam:DUF2983 HUT09_RS09400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT09_RS09430 ENOG4105BZU Histidine kinase HUT09_RS09435 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS09450 ENOG4105CPC Aldo Keto reductase HUT09_RS09455 ENOG4105VUF Transcriptional regulator HUT09_RS09495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS09500 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT09_RS09520 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT09_RS09530 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT09_RS09535 ENOG4108R86 Transcriptional regulator HUT09_RS09540 ENOG4105N14 lysine exporter protein LysE YggA HUT09_RS09545 ENOG4105EXN Sulfate transport protein CysZ HUT09_RS09550 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT09_RS09555 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_RS09585 ENOG4108XM1 transcriptional regulator AsnC family HUT09_RS09600 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT09_RS09605 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS09610 ENOG4105D8K carboxyl transferase HUT09_RS09615 ENOG4108IND Tetr family transcriptional regulator HUT09_RS09620 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT09_RS09650 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT09_RS09670 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS09690 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT09_RS09695 ENOG4106IBS oxygenase HUT09_RS09705 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS09790 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS09795 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUT09_RS09800 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_RS09810 ENOG4105C57 major facilitator superfamily HUT09_RS09820 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT09_RS09830 ENOG4108UB4 uncharacterized protein ygjQ HUT09_RS09835 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_RS09880 ENOG4108IFG nitrite reductase, (NAD(P)H) HUT09_RS09885 ENOG4107QZF nitrite reductase NADPH large subunit HUT09_RS09910 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT09_RS09920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS09925 ENOG4108UMI ABC transporter, permease HUT09_RS09940 ENOG4108TZY GntR Family Transcriptional Regulator HUT09_RS09955 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS09970 ENOG4108FN7 Aldo keto reductase HUT09_RS10010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT09_RS10020 ENOG4105CSV Glutaminase HUT09_RS10030 ENOG4105VMP Transcriptional regulator HUT09_RS10050 ENOG4105D74 hydrolase HUT09_RS10070 ENOG4105BZU Histidine kinase HUT09_RS10075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUT09_RS10175 ENOG4105PDP Short chain dehydrogenase HUT09_RS10205 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUT09_RS10230 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT09_RS10240 ENOG4105FDK ABC transporter HUT09_RS10255 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT09_RS10260 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT09_RS10275 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT09_RS10280 ENOG4105D4Y metalloprotease HUT09_RS10290 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT09_RS10310 ENOG4105MSB protein, conserved in bacteria HUT09_RS10320 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT09_RS10330 ENOG4107UEK pfkb domain protein HUT09_RS10345 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT09_RS10350 ENOG4107YU2 histidine triad (hIT) protein HUT09_RS10365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT09_RS10370 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT09_RS10400 ENOG4108IQE Amp-dependent synthetase and ligase HUT09_RS10405 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT09_RS10410 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT09_RS10445 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HUT09_RS10450 ENOG4105EPR degv family HUT09_RS10460 ENOG4105C8T Leucyl-tRNA synthetase HUT09_RS10470 ENOG4107QIZ NADH dehydrogenase HUT09_RS10495 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT09_RS10510 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT09_RS10525 ENOG4105D0M Protease HtpX homolog HUT09_RS10540 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT09_RS10550 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT09_RS10555 ENOG4107SJB teichoic acid biosynthesis HUT09_RS10575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT09_RS10580 ENOG4105K46 50S ribosomal protein l27 HUT09_RS10585 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT09_RS10590 ENOG4105J5G Transferase hexapeptide repeat containing protein HUT09_RS10600 ENOG4108IJ1 Dehydrogenase HUT09_RS10620 ENOG4105CK5 oxidoreductase HUT09_RS10630 ENOG4105C03 ribonuclease HUT09_RS10655 ENOG4105CNI cell division protein FtsW HUT09_RS10675 ENOG4105DFF Rod shape-determining protein mreb HUT09_RS10680 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT09_RS10690 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT09_RS10695 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT09_RS10705 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT09_RS10710 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT09_RS10715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT09_RS10720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT09_RS10740 ENOG4108TGC Acyltransferase HUT09_RS10750 ENOG4107S91 Sodium hydrogen exchanger HUT09_RS10775 ENOG4105C85 amino acid HUT09_RS10785 ENOG4105C85 amino acid HUT09_RS10790 ENOG4105C85 amino acid HUT09_RS10800 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUT09_RS10805 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT09_RS10810 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUT09_RS10815 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUT09_RS10820 ENOG41082BM Transcriptional regulator, arsr family HUT09_RS10830 ENOG4105EQK -acetyltransferase HUT09_RS10860 ENOG4105MC2 DSBA oxidoreductase HUT09_RS10875 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS10900 ENOG4105DUM transcriptional regulator, lysR family HUT09_RS10920 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 HUT09_RS10930 ENOG4105D8X mechanosensitive ion channel HUT09_RS10935 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HUT09_RS10945 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HUT09_RS10950 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT09_RS10955 ENOG4105F8D glycoside hydrolase family 4 HUT09_RS10970 ENOG4105CT1 (ABC) transporter HUT09_RS11000 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT09_RS11005 ENOG4108Z18 K06886 hemoglobin HUT09_RS11030 ENOG4105VHU single-stranded DNA-binding protein HUT09_RS11075 ENOG4105CJ1 ABC, transporter HUT09_RS11090 ENOG4105C26 Dehydrogenase HUT09_RS11095 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT09_RS11100 ENOG4105DH8 myo-inositol catabolism HUT09_RS11110 ENOG4105D7K pfkb domain protein HUT09_RS11135 ENOG4107R13 MMPL domain protein HUT09_RS11160 ENOG4105C7H Helicase, RecD TraA family HUT09_RS11240 ENOG41060NJ transcriptional regulator HUT09_RS11260 ENOG4105F0K SARP family transcriptional regulator HUT09_RS11265 ENOG4105CJA serine threonine protein kinase HUT09_RS11295 ENOG4105F8J Adenylate Guanylate cyclase HUT09_RS11315 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT09_RS11340 ENOG4105C7K acetolactate synthase HUT09_RS11350 ENOG4105CK7 Sodium proline symporter HUT09_RS11455 ENOG4105C29 acyl-CoA thioesterase HUT09_RS11465 ENOG4108XFF HUT09_RS11475 ENOG4105EXC Acyl-transferase HUT09_RS11505 ENOG4107QX3 carboxylase HUT09_RS11515 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT09_RS11520 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS11540 ENOG4105KVH Transcriptional regulator HUT09_RS11560 ENOG4105DY8 decarboxylase HUT09_RS11565 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT09_RS11575 ENOG4105DUU IucA IucC family protein HUT09_RS11595 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_RS11605 ENOG4105ECQ AraC Family Transcriptional Regulator HUT09_RS11610 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT09_RS11620 ENOG4108M1A Chitin-binding protein HUT09_RS11630 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS11640 ENOG4105DRS transport system, permease HUT09_RS11655 ENOG4105D0C transport protein HUT09_RS11660 ENOG4105D0C transport protein HUT09_RS11670 ENOG4108EUP Glycosyl hydrolase family 62 HUT09_RS11675 ENOG410804D Sensor Signal Transduction Histidine Kinase HUT09_RS11750 ENOG4105BZU Histidine kinase HUT09_RS11755 ENOG4105DEN Luciferase family HUT09_RS11765 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HUT09_RS11800 ENOG4105J5T Amp-dependent synthetase and ligase HUT09_RS11805 ENOG4108M1A Chitin-binding protein HUT09_RS11835 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT09_RS11865 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HUT09_RS11875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS11885 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT09_RS11890 ENOG41080U6 GntR family transcriptional regulator HUT09_RS11910 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT09_RS11915 ENOG4105D9R oxidoreductase HUT09_RS11920 ENOG41090KN UPF0303 protein HUT09_RS11930 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT09_RS11940 ENOG4108U4N (sortase) family HUT09_RS12000 ENOG4105DUM transcriptional regulator, lysR family HUT09_RS12030 ENOG4105EGE secreted protein HUT09_RS12045 ENOG41081E8 Alpha beta hydrolase HUT09_RS12060 ENOG4108KTG Membrane protein, drug metabolite transporter HUT09_RS12065 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT09_RS12070 ENOG4105C0W non-ribosomal peptide synthetase HUT09_RS12080 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT09_RS12085 ENOG4106BRA Membrane HUT09_RS12115 ENOG4105BZ4 penicillin-binding protein HUT09_RS12120 ENOG4105KPY Small multidrug resistance protein HUT09_RS12140 ENOG4105CSH Transporter HUT09_RS12150 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT09_RS12160 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT09_RS12180 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT09_RS12200 ENOG4105E0A ABC, transporter HUT09_RS12205 ENOG4105EHG Permease protein HUT09_RS12220 ENOG4105C85 amino acid HUT09_RS12230 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT09_RS12240 ENOG4108RWI nicotinamidase HUT09_RS12270 ENOG4105KF0 sporulation and cell division protein, SsgA HUT09_RS12275 ENOG4105CQB FAD linked oxidase domain protein HUT09_RS12285 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT09_RS12295 ENOG4105E90 ABC transporter HUT09_RS12300 ENOG4108IJ8 ABC transporter HUT09_RS12305 ENOG4105E90 ABC transporter HUT09_RS12310 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HUT09_RS12330 ENOG41063PX domain protein HUT09_RS12345 ENOG41086VY Fic/DOC family HUT09_RS12385 ENOG4105E2D ec 3.2.1.52 HUT09_RS12395 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT09_RS12410 ENOG4108UJU UPF0301 protein HUT09_RS12415 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT09_RS12430 ENOG4108426 dNA-binding protein HUT09_RS12440 ENOG4105EEM helicase HUT09_RS12440 ENOG4105EEM helicase HUT09_RS12465 ENOG4105DQQ Major facilitator superfamily MFS_1 HUT09_RS12485 ENOG4106NZI LysR family Transcriptional regulator HUT09_RS12495 ENOG4105KNA -acetyltransferase HUT09_RS12505 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT09_RS12510 ENOG4105CN1 protease HUT09_RS12515 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUT09_RS12520 ENOG4105CAK Cell division ATP-binding protein ftsE HUT09_RS12540 ENOG4108QVN serine threonine protein kinase HUT09_RS12545 ENOG4108UGD Serine Threonine protein kinase HUT09_RS12565 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT09_RS12570 ENOG4107SJB teichoic acid biosynthesis HUT09_RS12575 ENOG4105CG5 Glycosyl transferase (Group 1 HUT09_RS12580 ENOG4107SJB teichoic acid biosynthesis HUT09_RS12585 ENOG4107SJB teichoic acid biosynthesis HUT09_RS12595 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_RS12600 ENOG4107SJB teichoic acid biosynthesis HUT09_RS12605 ENOG4105K64 Glycosyl transferase, family 2 HUT09_RS12615 ENOG4108JGH Tetr family transcriptional regulator HUT09_RS12625 ENOG4105EY8 ABC transporter HUT09_RS12630 ENOG4105C7I Dehydrogenase HUT09_RS12655 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT09_RS12670 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS12675 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT09_RS12685 ENOG4105G3P Lipoprotein lpqB HUT09_RS12690 ENOG4105BZU Histidine kinase HUT09_RS12695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS12700 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT09_RS12715 ENOG4108WQ6 secreted protein HUT09_RS12720 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT09_RS12760 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT09_RS12770 ENOG4105EIP mannose-6-phosphate isomerase HUT09_RS12780 ENOG4105W49 UPF0434 protein HUT09_RS12785 ENOG4107QKV phosphomannomutase HUT09_RS12805 ENOG4107RGC Glycosyl transferase, family 2 HUT09_RS12810 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_RS12825 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT09_RS12835 ENOG4108S0S Nucleotidyl transferase HUT09_RS12850 ENOG4108KGH TRANSCRIPTIONal HUT09_RS12855 ENOG4107TB5 TRANSCRIPTIONal HUT09_RS12870 ENOG4108KGH TRANSCRIPTIONal HUT09_RS12880 ENOG4108KGH TRANSCRIPTIONal HUT09_RS12920 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT09_RS12955 ENOG41065SU Two-component system sensor kinase HUT09_RS12960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS12965 ENOG4105DUX Transporter HUT09_RS12995 ENOG41082AN stage II sporulation protein HUT09_RS13000 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS13005 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT09_RS13020 ENOG4105CGP Urocanate hydratase HUT09_RS13075 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS13100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_RS13105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_RS13110 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT09_RS13115 ENOG4105CEP NADH dehydrogenase HUT09_RS13135 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT09_RS13150 ENOG4106A3M Cytochrome p-450 HUT09_RS13170 ENOG4105D9P serine threonine protein kinase HUT09_RS13190 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT09_RS13265 ENOG4105CH2 amidohydrolase HUT09_RS13330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_RS13335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_RS13390 ENOG4106A3M Cytochrome p-450 HUT09_RS13420 ENOG4105ENE Histidine kinase HUT09_RS13435 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT09_RS13440 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT09_RS13445 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT09_RS13450 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT09_RS13460 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT09_RS13470 ENOG4108IG5 Transcriptional regulator HUT09_RS13485 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_RS13490 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT09_RS13495 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS13505 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT09_RS13550 ENOG4105C5H ABC transporter HUT09_RS13555 ENOG4105VTW prevent-host-death family HUT09_RS13560 ENOG4105KRQ Addiction module toxin, Txe YoeB family HUT09_RS13575 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT09_RS13585 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT09_RS13590 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT09_RS13600 ENOG4105F8V Hydrolase, tatD family HUT09_RS13630 ENOG4108A04 Beta-lactamase HUT09_RS13680 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT09_RS13725 ENOG4108JJB ABC transporter HUT09_RS13735 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein HUT09_RS13745 ENOG41067TZ transcriptional regulator, MarR family HUT09_RS13765 ENOG4105EYF MMPL domain protein HUT09_RS13795 ENOG4108BAS reductase HUT09_RS13805 ENOG4105F95 Monooxygenase HUT09_RS13815 ENOG4105CGK Exodeoxyribonuclease III HUT09_RS13820 ENOG4108Z7F N-acetyltransferase HUT09_RS13825 ENOG4105K4I Scp-like extracellular HUT09_RS13835 ENOG4106T9R serine protease HUT09_RS13855 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUT09_RS13860 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT09_RS13870 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT09_RS13875 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT09_RS13885 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HUT09_RS13900 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT09_RS13910 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT09_RS13930 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUT09_RS13935 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT09_RS13975 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUT09_RS14000 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS14070 ENOG4105CHR reductase HUT09_RS14105 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT09_RS14115 ENOG4105D8V Glucose sorbosone dehydrogenase HUT09_RS14120 ENOG4105CJN penicillin-binding protein HUT09_RS14180 ENOG4105CPC Aldo Keto reductase HUT09_RS14190 ENOG4108J20 pectate lyase HUT09_RS14195 ENOG4105WEM extracellular solute-binding protein HUT09_RS14230 ENOG4105DRR Transcriptional regulator, GntR family HUT09_RS14235 ENOG4105E9Z Nad-dependent epimerase dehydratase HUT09_RS14285 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS14290 ENOG4105CHR reductase HUT09_RS14305 ENOG4108R86 Transcriptional regulator HUT09_RS14335 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS14365 ENOG4105DVY radical SAM domain protein HUT09_RS14380 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT09_RS14390 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HUT09_RS14395 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT09_RS14405 ENOG4105C26 Dehydrogenase HUT09_RS14410 ENOG4105CRE cytochrome C HUT09_RS14415 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HUT09_RS14420 ENOG4107QIV Cytochrome c biogenesis protein HUT09_RS14435 ENOG4105E93 esterase HUT09_RS14440 ENOG4108RH7 phosphoglycerate mutase HUT09_RS14445 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT09_RS14475 ENOG4105E2Y ABC, transporter HUT09_RS14490 ENOG4105E0Y RtcB Protein HUT09_RS14510 ENOG4105DK7 lysyl-tRNA synthetase HUT09_RS14515 ENOG4105C75 arginyL-tRNA synthetase HUT09_RS14525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT09_RS14550 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT09_RS14570 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT09_RS14575 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT09_RS14580 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT09_RS14585 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT09_RS14590 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT09_RS14635 ENOG4108XFF HUT09_RS14645 ENOG4106UW1 Major Facilitator superfamily HUT09_RS14650 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT09_RS14670 ENOG4105II7 pyrroline-5-carboxylate reductase HUT09_RS14680 ENOG4105CJ1 ABC, transporter HUT09_RS14690 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HUT09_RS14700 ENOG4105C01 Dihydroxy-acid dehydratase HUT09_RS14705 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT09_RS14710 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT09_RS14715 ENOG4107R33 ppx gppa phosphatase HUT09_RS14720 ENOG4108JWX HUT09_RS14735 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT09_RS14745 ENOG4105CEN a g-specific adenine glycosylase HUT09_RS14750 ENOG4105NAF rna polymerase sigma factor HUT09_RS14755 ENOG41075QH Lipoprotein CseA HUT09_RS14760 ENOG4108PYU two-component system response regulator HUT09_RS14765 ENOG4108FKE two-component system sensor kinase HUT09_RS14770 ENOG4105DR5 peptidase HUT09_RS14820 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT09_RS14830 ENOG4108IYU L-aspartate oxidase HUT09_RS14835 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT09_RS14860 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS14875 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS14885 ENOG4108HQR Glycine betaine HUT09_RS14890 ENOG4105E90 ABC transporter HUT09_RS14895 ENOG4105E90 ABC transporter HUT09_RS14900 ENOG4108IJ8 ABC transporter HUT09_RS14910 ENOG4105CRK lysyL-tRNA synthetase HUT09_RS14930 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUT09_RS14940 ENOG4105EUJ GTP cyclohydrolase i HUT09_RS14950 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUT09_RS14955 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT09_RS14970 ENOG4105F0N pyrophosphate phospho-hydrolase HUT09_RS14980 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT09_RS14985 ENOG41082VC UPF0145 protein HUT09_RS14990 ENOG4105VCT ion-transport protein YfeO HUT09_RS14995 ENOG4105CS1 NAD(P)H quinone oxidoreductase HUT09_RS15000 ENOG4105CVK Glutamate decarboxylase HUT09_RS15020 ENOG4105C26 Dehydrogenase HUT09_RS15060 ENOG4105C2M dna polymerase I HUT09_RS15080 ENOG4106T9R serine protease HUT09_RS15090 ENOG4107T0D ABC, transporter HUT09_RS15115 ENOG4108ZJ4 polysaccharide deacetylase HUT09_RS15135 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS15140 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT09_RS15150 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT09_RS15190 ENOG4105C6E dna polymerase iii HUT09_RS15195 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT09_RS15200 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT09_RS15210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_RS15220 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT09_RS15225 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT09_RS15230 ENOG4105WN5 stage II sporulation protein HUT09_RS15235 ENOG4108I5C dEAD DEAH box helicase HUT09_RS15330 ENOG4105C4R Atp-dependent dna helicase HUT09_RS15370 ENOG4107B2H carbonic anhydrase HUT09_RS15375 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT09_RS15380 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_RS15390 ENOG4105D74 hydrolase HUT09_RS15415 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT09_RS15450 ENOG4108JQC penicillin-binding protein 1A HUT09_RS15455 ENOG4105KTH gatB Yqey HUT09_RS15480 ENOG4108TCJ secreted hydrolase HUT09_RS15490 ENOG4105DR4 Methyltransferase HUT09_RS15510 ENOG4105NAF rna polymerase sigma factor HUT09_RS15520 ENOG4105CFH Aspartokinase HUT09_RS15550 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT09_RS15555 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT09_RS15570 ENOG4105DRR Transcriptional regulator, GntR family HUT09_RS15575 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT09_RS15580 ENOG4108V4B ThiJ pfpI HUT09_RS15590 ENOG4108762 serine threonine protein kinase HUT09_RS15595 ENOG4106UW1 Major Facilitator superfamily HUT09_RS15605 ENOG4108RFG Tetr family transcriptional regulator HUT09_RS15655 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT09_RS15665 ENOG4105EMN RNA polymerase sigma factor HUT09_RS15690 ENOG4105CVA phosphate HUT09_RS15695 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT09_RS15720 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS15740 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT09_RS15765 ENOG4105C87 Aminotransferase class I and II HUT09_RS15770 ENOG4107RCW fructose-bisphosphate aldolase HUT09_RS15775 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT09_RS15790 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT09_RS15815 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT09_RS15840 ENOG4105KNI merR family transcriptional Regulator HUT09_RS15845 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT09_RS15850 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT09_RS15855 ENOG4105CFG Acts as a chaperone (By similarity) HUT09_RS15860 ENOG4105D3Q Sugar transferase HUT09_RS15865 ENOG4105DF6 Fe-S oxidoreductase HUT09_RS15885 ENOG4105DHP deoxycytidine triphosphate deaminase HUT09_RS15930 ENOG4105DKQ ROK family HUT09_RS15945 ENOG4105CHR reductase HUT09_RS15950 ENOG4105CPQ Dehydrogenase HUT09_RS15955 ENOG4108KK4 3-dehydroquinate synthase HUT09_RS15960 ENOG4107QKV phosphomannomutase HUT09_RS15980 ENOG41065SU Two-component system sensor kinase HUT09_RS15985 ENOG4108KXV response regulator HUT09_RS16000 ENOG4105FF0 ErfK YbiS YcfS YnhG HUT09_RS16005 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT09_RS16030 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_RS16050 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT09_RS16070 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT09_RS16080 ENOG4105EBR Carboxylesterase HUT09_RS16085 ENOG4105CAQ asparagine synthetase HUT09_RS16100 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_RS16120 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS16130 ENOG4108FKE two-component system sensor kinase HUT09_RS16135 ENOG4108PYU two-component system response regulator HUT09_RS16150 ENOG4105CHR reductase HUT09_RS16165 ENOG4105ETX regulatoR HUT09_RS16175 ENOG4107SDT Homocitrate synthase HUT09_RS16185 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HUT09_RS16190 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT09_RS16200 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT09_RS16205 ENOG4105D82 Glutamate dehydrogenase HUT09_RS16210 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT09_RS16250 ENOG4107S5I aldo keto reductase HUT09_RS16260 ENOG4105FKQ transcriptional regulator HUT09_RS16265 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUT09_RS16290 ENOG4106P4H Cytochrome P450 HUT09_RS16295 ENOG4105DU1 integral membrane protein, terc HUT09_RS16310 ENOG4105X1Q TOBE domain protein HUT09_RS16325 ENOG4105KWG Pfam:DUF1696 HUT09_RS16335 ENOG4105CUB amino acid HUT09_RS16345 ENOG4107RWR Sodium hydrogen exchanger HUT09_RS16355 ENOG4105EYF MMPL domain protein HUT09_RS16360 ENOG4108TGC Acyltransferase HUT09_RS16375 ENOG4105C1J atp-dependent rna helicase HUT09_RS16380 ENOG4105VEQ Cold shock protein HUT09_RS16420 ENOG4105BZU Histidine kinase HUT09_RS16425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS16460 ENOG4108SZE gCN5-related N-acetyltransferase HUT09_RS16485 ENOG4105DZ6 Band 7 protein HUT09_RS16525 ENOG4105NCW Trka-c domain protein HUT09_RS16530 ENOG4107S91 Sodium hydrogen exchanger HUT09_RS16555 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT09_RS16565 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT09_RS16575 ENOG4105EUZ Beta-lactamase domain protein HUT09_RS16580 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT09_RS16585 ENOG4108UZX fmn reductase HUT09_RS16640 ENOG4106F60 Histidine kinase HUT09_RS16645 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT09_RS16650 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT09_RS16660 ENOG4105C9M aspartyl-trna synthetase HUT09_RS16675 ENOG4105EUB pirin domain protein HUT09_RS16685 ENOG4105CSU acyl-Coa dehydrogenase HUT09_RS16695 ENOG4105DFM M18 family aminopeptidase HUT09_RS16720 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUT09_RS16735 ENOG4108WYP Transcriptional regulator HUT09_RS16755 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT09_RS16760 ENOG4105CPP Dehydrogenase, E1 component HUT09_RS16790 ENOG4107QPV Serine Threonine protein kinase HUT09_RS16805 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT09_RS16815 ENOG4108VC7 Protein of unknown function (DUF2587) HUT09_RS16830 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUT09_RS16835 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUT09_RS16840 ENOG4107QSN dihydrolipoamide acetyltransferase HUT09_RS16860 ENOG4108IG5 Transcriptional regulator HUT09_RS16885 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT09_RS16890 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT09_RS16895 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT09_RS16900 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT09_RS16905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT09_RS16915 ENOG41085GJ domain protein HUT09_RS16930 ENOG4105KVH Transcriptional regulator HUT09_RS16935 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT09_RS16940 ENOG41064MX Tetr family transcriptional regulator HUT09_RS16950 ENOG4105TV9 FHA Domain-Containing protein HUT09_RS16955 ENOG4105HZM Fha domain containing protein HUT09_RS16970 ENOG4105CJN penicillin-binding protein HUT09_RS16980 ENOG4108RN7 integral membrane protein HUT09_RS16985 ENOG4108U4N (sortase) family HUT09_RS17000 ENOG4108U4N (sortase) family HUT09_RS17010 ENOG4105ZJT Cell division protein CrgA HUT09_RS17060 ENOG4108UGD Serine Threonine protein kinase HUT09_RS17090 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT09_RS17100 ENOG4105K7N UPF0232 protein HUT09_RS17105 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT09_RS17110 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT09_RS17115 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT09_RS17130 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HUT09_RS17135 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT09_RS17140 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT09_RS17150 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT09_RS17155 ENOG4107QJE Chromosome Partitioning Protein HUT09_RS17170 ENOG4105K63 Thioredoxin HUT09_RS17175 ENOG4105C3M thioredoxin reductase HUT09_RS17190 ENOG4105D9P serine threonine protein kinase HUT09_RS17205 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT09_RS17225 ENOG4105BZ4 penicillin-binding protein HUT09_RS17250 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT09_RS17255 ENOG4107YH6 single-stranded DNA-binding protein HUT09_RS17260 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT09_RS17265 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT09_RS17270 ENOG4107QI1 Mate efflux family protein HUT09_RS17275 ENOG4105CDU Replicative dna helicase HUT09_RS17290 ENOG4105ED2 Beta-lactamase HUT09_RS17295 ENOG410849A acetyltransferase, (GNAT) family HUT09_RS17300 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HUT09_RS17305 ENOG4105F27 Major Facilitator HUT09_RS17325 ENOG4105C28 cystathionine HUT09_RS17330 ENOG41082T9 Membrane HUT09_RS17335 ENOG4106048 Cupin 2, conserved barrel domain protein HUT09_RS17360 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT09_RS17370 ENOG4105KAF membrAne HUT09_RS17380 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUT09_RS17385 ENOG4107P2S Transcriptional regulator HUT09_RS17390 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT09_RS17395 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT09_RS17400 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT09_RS17405 ENOG4108JJ9 ABC, transporter HUT09_RS17415 ENOG410667J hydrolase HUT09_RS17425 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT09_RS17430 ENOG4107SWG transcriptional regulator MERR family HUT09_RS17445 ENOG4105DA5 (ABC) transporter HUT09_RS17470 ENOG410667J hydrolase HUT09_RS17475 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT09_RS17480 ENOG4105CQC Prephenate dehydratase HUT09_RS17485 ENOG4105DBE peroxidase HUT09_RS17490 ENOG4105JDN Copper resistance protein HUT09_RS17520 ENOG4107T6F Xaa-Pro aminopeptidase HUT09_RS17540 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT09_RS17580 ENOG4105X7H acyl-CoA dehydrogenase HUT09_RS17605 ENOG4105NAF rna polymerase sigma factor HUT09_RS17610 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS17640 ENOG4108KPJ rna polymerase sigma factor HUT09_RS17660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS17665 ENOG4105BZU Histidine kinase HUT09_RS17675 ENOG4105EDW glycosyl transferase, family 39 HUT09_RS17690 ENOG4105C57 major facilitator superfamily HUT09_RS17705 ENOG410905P Pyridoxamine 5-phosphate HUT09_RS17710 ENOG4108YYC ycei family HUT09_RS17720 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT09_RS17735 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS17740 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS17745 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HUT09_RS17760 ENOG4108Z6B deaminase HUT09_RS17775 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT09_RS17805 ENOG4105CHP RNA polymerase HUT09_RS17815 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT09_RS17865 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT09_RS17870 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HUT09_RS17885 ENOG41081F0 Precorrin-8x methylmutase HUT09_RS17895 ENOG4105CTK cobaltochelatase, cobn subunit HUT09_RS17970 ENOG4105GFG DUF218 domain HUT09_RS18025 ENOG4107ZVI PhiRv2 prophage protein HUT09_RS18035 ENOG4107T65 Integrase HUT09_RS18055 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT09_RS18070 ENOG4105C8V SAICAR synthetase HUT09_RS18080 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS18115 ENOG410839H phosphoribosylformylglycinamidine synthase HUT09_RS18120 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT09_RS18125 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT09_RS18135 ENOG4105E4C Lytic transglycosylase catalytic HUT09_RS18155 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT09_RS18190 ENOG4105CQ7 ATP-dependent helicase HUT09_RS18200 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_RS18205 ENOG4107QIV Cytochrome c biogenesis protein HUT09_RS18235 ENOG41083YR Protein CrcB homolog HUT09_RS18240 ENOG41083TI Protein CrcB homolog HUT09_RS18250 ENOG4105C1J atp-dependent rna helicase HUT09_RS18260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT09_RS18270 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT09_RS18285 ENOG4107TXC Transcriptional regulator HUT09_RS18295 ENOG4105E4C Lytic transglycosylase catalytic HUT09_RS18300 ENOG4105CPC Aldo Keto reductase HUT09_RS18310 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT09_RS18315 ENOG4105D5U fad dependent oxidoreductase HUT09_RS18375 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS18380 ENOG4105BZU Histidine kinase HUT09_RS18390 ENOG4105CJ1 ABC, transporter HUT09_RS18455 ENOG4105E4C Lytic transglycosylase catalytic HUT09_RS18460 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUT09_RS18475 ENOG4105VPX protein, conserved in bacteria HUT09_RS18485 ENOG4105CJ3 phosphate transporter HUT09_RS18490 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS18505 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUT09_RS18520 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT09_RS18530 ENOG4105E2Y ABC, transporter HUT09_RS18535 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT09_RS18545 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_RS18555 ENOG4105CGH 5'-nucleotidase HUT09_RS18570 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT09_RS18605 ENOG4105C57 major facilitator superfamily HUT09_RS18650 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C HUT09_RS18670 ENOG4105C0H protease HUT09_RS18680 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS18685 ENOG4107NHD transcriptional regulator HUT09_RS18710 ENOG4105KHC sulfurtransferase HUT09_RS18715 ENOG4105PKJ carbohydrate binding HUT09_RS18745 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT09_RS18750 ENOG41090R7 Ferric uptake HUT09_RS18755 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT09_RS18760 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT09_RS18775 ENOG4105HHS UPF0256 protein HUT09_RS18840 ENOG4105RV9 Transcriptional regulator HUT09_RS18855 ENOG4108JIK carboxylase HUT09_RS18880 ENOG4105CZS beta-ketoacyl synthase HUT09_RS18910 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT09_RS18915 ENOG4105D8K carboxyl transferase HUT09_RS18950 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT09_RS18960 ENOG4105KVH Transcriptional regulator HUT09_RS19010 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_RS19015 ENOG4108YZJ Pfam:DUF2596 HUT09_RS19115 ENOG4105CMD Transcriptional regulator, GntR family HUT09_RS19160 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT09_RS19170 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT09_RS19190 ENOG4105BZU Histidine kinase HUT09_RS19205 ENOG4108VJ1 Transcriptional regulator (CarD family HUT09_RS19210 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT09_RS19215 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT09_RS19225 ENOG4105C8N cysteinyl-tRNA synthetase HUT09_RS19230 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT09_RS19240 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT09_RS19265 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HUT09_RS19270 ENOG4107S9F NmrA family HUT09_RS19290 ENOG4105CJP fad dependent oxidoreductase HUT09_RS19310 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT09_RS19330 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS19335 ENOG4105ENE Histidine kinase HUT09_RS19345 ENOG4107SNB ankyrin repeat protein YahD HUT09_RS19370 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT09_RS19380 ENOG4105BZU Histidine kinase HUT09_RS19395 ENOG4105CE4 GlcNAc 6-P deacetylase HUT09_RS19420 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT09_RS19425 ENOG4105C3Q Glycosyl transferase, family 2 HUT09_RS19485 ENOG4105EMN RNA polymerase sigma factor HUT09_RS19510 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT09_RS19530 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS19560 ENOG4105BZU Histidine kinase HUT09_RS19565 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_RS19595 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT09_RS19600 ENOG4106G6Q Transcriptional regulator HUT09_RS19640 ENOG4105E7W lamb ycsf family protein HUT09_RS19660 ENOG4106N3A copper homeostasis protein cutc HUT09_RS19665 ENOG4105EEM helicase HUT09_RS19675 ENOG4105CFI type iii restriction protein res subunit HUT09_RS19690 ENOG4107T6F Xaa-Pro aminopeptidase HUT09_RS19695 ENOG4105KXC Collagenase HUT09_RS19740 ENOG4108MES Periplasmic binding protein HUT09_RS19745 ENOG4105E0A ABC, transporter HUT09_RS19750 ENOG4105TVJ transport system, permease HUT09_RS19755 ENOG4105DQ5 transport system permease protein HUT09_RS19775 ENOG4105VEQ Cold shock protein HUT09_RS19780 ENOG4105E63 Pfam:DUF178 HUT09_RS19785 ENOG4108UIH futalosine nucleosidase HUT09_RS19795 ENOG4108N0W Major Facilitator superfamily HUT09_RS19825 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT09_RS19835 ENOG4105C7N Xanthine uracil vitamin C permease HUT09_RS19845 ENOG4105XMC MarR family Transcriptional regulator HUT09_RS19855 ENOG4105CPC Aldo Keto reductase HUT09_RS19875 ENOG4107TPY serine threonine protein kinase HUT09_RS19885 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT09_RS19890 ENOG4108M0I Transcriptional regulator HUT09_RS19910 ENOG4108KPJ rna polymerase sigma factor HUT09_RS19970 ENOG41067SE Tetr family transcriptional regulator HUT09_RS19975 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT09_RS19980 ENOG4108KTG Membrane protein, drug metabolite transporter HUT09_RS19990 ENOG4108Z6Z Transcriptional regulator HUT09_RS19995 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_RS20045 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT09_RS20065 ENOG4105CHJ isochorismatase hydrolase HUT09_RS20105 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT09_RS20135 ENOG4108TQ9 Histidine kinase HUT09_RS20140 ENOG4105CQB FAD linked oxidase domain protein HUT09_RS20150 ENOG4106NZI LysR family Transcriptional regulator HUT09_RS20160 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A HUT09_RS20170 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT09_RS20185 ENOG4107QX3 carboxylase HUT09_RS20200 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS20205 ENOG41060WC Enoyl-CoA hydratase HUT09_RS20235 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_RS20245 ENOG4108BQ6 cytochrome p450 HUT09_RS20270 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT09_RS20280 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_RS20285 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT09_RS20300 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT09_RS20305 ENOG4106F60 Histidine kinase HUT09_RS20310 ENOG4108SU4 UPF0309 protein HUT09_RS20320 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT09_RS20335 ENOG4105CJ1 ABC, transporter HUT09_RS20380 ENOG41082AN stage II sporulation protein HUT09_RS20385 ENOG4107EG8 signal transduction protein with EFhand domain HUT09_RS20390 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS20400 ENOG4105CC9 acyl-Coa dehydrogenase HUT09_RS20405 ENOG4105D2B acyl-CoA dehydrogenase HUT09_RS20420 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT09_RS20425 ENOG4105CC9 acyl-Coa dehydrogenase HUT09_RS20470 ENOG4105D2S major facilitator superfamily HUT09_RS20475 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT09_RS20485 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HUT09_RS20505 ENOG4105CGU Enoyl-CoA hydratase HUT09_RS20530 ENOG4108JQ1 Dehydrogenase HUT09_RS20540 ENOG4107S9F NmrA family HUT09_RS20545 ENOG4105IIU Aminopeptidase HUT09_RS20555 ENOG4105H3G oxidoreductase HUT09_RS20560 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HUT09_RS20565 ENOG4105DQ5 transport system permease protein HUT09_RS20570 ENOG4105TVJ transport system, permease HUT09_RS20590 ENOG4105D0M Protease HtpX homolog HUT09_RS20595 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT09_RS20605 ENOG4105D2B acyl-CoA dehydrogenase HUT09_RS20615 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT09_RS20640 ENOG4105E39 Enoyl-CoA hydratase HUT09_RS20655 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS20665 ENOG4105F0K SARP family transcriptional regulator HUT09_RS20680 ENOG4105VEQ Cold shock protein HUT09_RS20685 ENOG4105EV6 Pfam:DUF178 HUT09_RS20695 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT09_RS20720 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_RS20725 ENOG4106FTQ Taurine ABC transporter, periplasmic HUT09_RS20740 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT09_RS20785 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS20790 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT09_RS20795 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS20805 ENOG4107QIZ NADH dehydrogenase HUT09_RS20810 ENOG4108IEH NADH dehydrogenase subunit g HUT09_RS20815 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT09_RS20820 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS20825 ENOG41087XN oxidoreductase HUT09_RS20830 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS20835 ENOG4105D65 subunit l HUT09_RS20845 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS20850 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT09_RS20860 ENOG4105ERH Fumarylacetoacetate hydrolase HUT09_RS20870 ENOG4105DUX Transporter HUT09_RS20885 ENOG4105CJ1 ABC, transporter HUT09_RS20915 ENOG4105DQF Hydrolase HUT09_RS20920 ENOG4106T9R serine protease HUT09_RS20955 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HUT09_RS20985 ENOG4105ECR NmrA family HUT09_RS20990 ENOG4105KVH Transcriptional regulator HUT09_RS20995 ENOG4105DQU oxidoreductase, subunit beta HUT09_RS21000 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT09_RS21020 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT09_RS21025 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS21030 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT09_RS21035 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT09_RS21040 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS21045 ENOG4107YX3 NADH dehydrogenase subunit j HUT09_RS21050 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS21055 ENOG4105D65 subunit l HUT09_RS21060 ENOG4105C8S subunit m HUT09_RS21065 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT09_RS21070 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT09_RS21075 ENOG4105D0M Protease HtpX homolog HUT09_RS21080 ENOG410901E Membrane HUT09_RS21095 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT09_RS21100 ENOG4108VPT UPF0234 protein HUT09_RS21130 ENOG4105WDJ 50S ribosomal protein L33 HUT09_RS21135 ENOG410900P UPF0336 protein HUT09_RS21145 ENOG4107R4N Cell wall formation (By similarity) HUT09_RS21175 ENOG410683Z Preprotein translocase SecE subunit HUT09_RS21180 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUT09_RS21185 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT09_RS21190 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT09_RS21200 ENOG4108VZM 50s ribosomal protein L10 HUT09_RS21210 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT09_RS21215 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT09_RS21320 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT09_RS21325 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT09_RS21330 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT09_RS21355 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT09_RS21360 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT09_RS21365 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT09_RS21370 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT09_RS21375 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT09_RS21380 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT09_RS21385 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT09_RS21390 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT09_RS21395 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT09_RS21400 ENOG41082SA 50s ribosomal protein l29 HUT09_RS21405 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT09_RS21410 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT09_RS21415 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT09_RS21420 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT09_RS21425 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT09_RS21430 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT09_RS21435 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT09_RS21440 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT09_RS21445 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT09_RS21450 ENOG410849U 50S ribosomal protein L30 HUT09_RS21455 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT09_RS21460 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUT09_RS21465 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT09_RS21475 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT09_RS21485 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT09_RS21490 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT09_RS21495 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT09_RS21500 ENOG4108ZT0 50S ribosomal protein l17 HUT09_RS21505 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT09_RS21520 ENOG4105C5H ABC transporter HUT09_RS21525 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT09_RS21530 ENOG4108UJD 30S ribosomal protein S9 HUT09_RS21535 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT09_RS21545 ENOG4105CS9 pantothenic acid kinase HUT09_RS21550 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS21565 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_RS21575 ENOG4105GRZ Ycii-related protein HUT09_RS21580 ENOG4105CHP RNA polymerase HUT09_RS21600 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_RS21605 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT09_RS21615 ENOG4105K78 MarR family Transcriptional regulator HUT09_RS21620 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT09_RS21625 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT09_RS21630 ENOG4108097 ATP-binding protein HUT09_RS21655 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT09_RS21705 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT09_RS21720 ENOG4105DRS transport system, permease HUT09_RS21725 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT09_RS21740 ENOG4105EMU Dehydrogenase HUT09_RS21750 ENOG4105DND Transcriptional regulator HUT09_RS21755 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_RS21765 ENOG4108MMM RNA Polymerase HUT09_RS21775 ENOG4107QVP Dehydrogenase HUT09_RS21785 ENOG4107QQG Dehydrogenase HUT09_RS21805 ENOG4107TPY serine threonine protein kinase HUT09_RS21810 ENOG4105C26 Dehydrogenase HUT09_RS21830 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT09_RS21860 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS21870 ENOG4105K4H Nlp p60 protein HUT09_RS21910 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT09_RS21915 ENOG4105RD5 HUT09_RS21920 ENOG4105DEG Vwa containing coxe family protein HUT09_RS21925 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT09_RS21955 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT09_RS21970 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT09_RS21985 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT09_RS22005 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_RS22010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT09_RS22025 ENOG4106032 Glutathionylspermidine synthase HUT09_RS22030 ENOG4105C8Y Acetylornithine aminotransferase HUT09_RS22035 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT09_RS22055 ENOG4107H3J ribonuclease HUT09_RS22065 ENOG4107RN3 metallophosphoesterase HUT09_RS22075 ENOG4108RZE Tetr family transcriptional regulator HUT09_RS22105 ENOG4108J01 L-aspartate oxidase HUT09_RS22125 ENOG4105E2D ec 3.2.1.52 HUT09_RS22205 ENOG4105F0K SARP family transcriptional regulator HUT09_RS22215 ENOG4105F0K SARP family transcriptional regulator HUT09_RS22225 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT09_RS22240 ENOG4108MMM RNA Polymerase HUT09_RS22255 ENOG4108NIW Leucine export protein LeuE HUT09_RS22280 ENOG4108478 ec 3.2.1.18 HUT09_RS22295 ENOG4105K64 Glycosyl transferase, family 2 HUT09_RS22305 ENOG4105F0R Cytidylyltransferase HUT09_RS22320 ENOG4107RM1 amidohydrolase HUT09_RS22325 ENOG4105DIH basic membrane HUT09_RS22330 ENOG4108JQ9 ABC transporter HUT09_RS22335 ENOG4105UIB (ABC) transporter HUT09_RS22380 ENOG4105D94 Major Facilitator Superfamily HUT09_RS22385 ENOG4107RSM transcriptional regulator HUT09_RS22395 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT09_RS22420 ENOG41065SU Two-component system sensor kinase HUT09_RS22425 ENOG4108KXV response regulator HUT09_RS22430 ENOG4105NAF rna polymerase sigma factor HUT09_RS22460 ENOG4105C26 Dehydrogenase HUT09_RS22465 ENOG4105C26 Dehydrogenase HUT09_RS22480 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT09_RS22510 ENOG4108JIK carboxylase HUT09_RS22520 ENOG4107WR6 Maf-like protein HUT09_RS22530 ENOG4105D8K carboxyl transferase HUT09_RS22540 ENOG4108QER Adenylate cyclase HUT09_RS22545 ENOG4105E39 Enoyl-CoA hydratase HUT09_RS22550 ENOG4105KDM Diguanylate cyclase with gaf sensor HUT09_RS22555 ENOG4105C84 Histidine ammonia-lyase HUT09_RS22570 ENOG4105FF0 ErfK YbiS YcfS YnhG HUT09_RS22590 ENOG4107R37 Glutamate dehydrogenase HUT09_RS22615 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT09_RS22640 ENOG4105NAF rna polymerase sigma factor HUT09_RS22650 ENOG4105BZU Histidine kinase HUT09_RS22660 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT09_RS22665 ENOG4105FUA antagonist HUT09_RS22670 ENOG4107MMM Anti-sigma-factor antagonist HUT09_RS22675 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT09_RS22680 ENOG4105C7B Threonine dehydratase HUT09_RS22695 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT09_RS22705 ENOG4105T1M mycothiol conjugate amidase mca HUT09_RS22725 ENOG4105C7Z Conserved Protein HUT09_RS22735 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT09_RS22780 ENOG4105KVH Transcriptional regulator HUT09_RS22815 ENOG4108FUF Transcriptional regulator, IclR family HUT09_RS22820 ENOG4105KME endoribonuclease L-psp HUT09_RS22825 ENOG4105C6Z Gluconate HUT09_RS22890 ENOG4105RAK Histidine kinase HUT09_RS22895 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS22915 ENOG4107QKZ Ompa motb domain protein HUT09_RS22975 ENOG4105CPC Aldo Keto reductase HUT09_RS22980 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT09_RS22985 ENOG4108IAB Phoh family HUT09_RS23000 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT09_RS23005 ENOG4105D3R alkyl hydroperoxide reductase HUT09_RS23020 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT09_RS23040 ENOG4105BZ4 penicillin-binding protein HUT09_RS23055 ENOG4105C9Q fumarate hydratase class II HUT09_RS23065 ENOG4105DFM M18 family aminopeptidase HUT09_RS23070 ENOG4107GFK fumarate HUT09_RS23095 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT09_RS23105 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT09_RS23115 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT09_RS23130 ENOG4105C3G gtp-binding protein HUT09_RS23190 ENOG4108Z6Z Transcriptional regulator HUT09_RS23235 ENOG41087YS Phage shock protein A HUT09_RS23245 ENOG4105CKK Glycosyl transferase, family 2 HUT09_RS23255 ENOG4105CHP RNA polymerase HUT09_RS23260 ENOG4105GRZ Ycii-related protein HUT09_RS23370 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT09_RS23400 ENOG4105DRS transport system, permease HUT09_RS23405 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT09_RS23420 ENOG4105KA0 thioesterase Superfamily protein HUT09_RS23425 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS23435 ENOG4105CI3 gtp-binding protein typa HUT09_RS23445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_RS23450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS23455 ENOG4105C3U ABC transporter HUT09_RS23460 ENOG4108JQ7 (ABC) transporter HUT09_RS23470 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_RS23475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS23480 ENOG4105C3U ABC transporter HUT09_RS23485 ENOG4108JQ7 (ABC) transporter HUT09_RS23500 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT09_RS23515 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT09_RS23520 ENOG4105EGE secreted protein HUT09_RS23530 ENOG4108UW5 maltose o-acetyltransferase HUT09_RS23545 ENOG4105CJA serine threonine protein kinase HUT09_RS23570 ENOG41063JG Transcriptional regulator HUT09_RS23580 ENOG4108Z4U Ferredoxin HUT09_RS23600 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT09_RS23605 ENOG4108URH decarboxylase HUT09_RS23610 ENOG4105EEI dihydropteroate synthase HUT09_RS23620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT09_RS23625 ENOG4105CGU Enoyl-CoA hydratase HUT09_RS23640 ENOG4105DU6 RNA polymerase HUT09_RS23655 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT09_RS23690 ENOG4105D7N magnesium and cobalt transport protein CorA HUT09_RS23700 ENOG4105DXB Major Facilitator superfamily HUT09_RS23710 ENOG4105DB7 PHP domain protein HUT09_RS23715 ENOG41081FY multiple antibiotic resistance (MarC)-related HUT09_RS23735 ENOG4105C1J atp-dependent rna helicase HUT09_RS23775 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_RS23780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS23785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_RS23845 ENOG4105C4R Atp-dependent dna helicase HUT09_RS23850 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT09_RS23875 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_RS23890 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUT09_RS23945 ENOG41063PX domain protein HUT09_RS23955 ENOG4105DJZ UPF0182 protein HUT09_RS23990 ENOG4107TK4 histidinol-phosphate phosphatase HUT09_RS24005 ENOG4105KPY Small multidrug resistance protein HUT09_RS24010 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT09_RS24015 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_RS24025 ENOG4108RAV Conserved protein HUT09_RS24035 ENOG4105EMN RNA polymerase sigma factor HUT09_RS24040 ENOG4105WMN AntiSigma factor HUT09_RS24045 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_RS24060 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT09_RS24090 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT09_RS24095 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT09_RS24105 ENOG4105D22 carbon starvation protein HUT09_RS24110 ENOG4105FDP GntR family transcriptional regulator HUT09_RS24130 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT09_RS24135 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HUT09_RS24140 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_RS24155 ENOG4105CBD Diacylglycerol kinase HUT09_RS24170 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT09_RS24195 ENOG41081JD Transcriptional regulator HUT09_RS24200 ENOG4105ESN nucleotide-binding protein HUT09_RS24225 ENOG4107SQD Transcriptional regulator, GntR family HUT09_RS24260 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS24265 ENOG4105BZU Histidine kinase HUT09_RS24285 ENOG4108VEQ Superoxide dismutase HUT09_RS24300 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_RS24305 ENOG4105NAF rna polymerase sigma factor HUT09_RS24315 ENOG4105CDA abc transporter atp-binding protein HUT09_RS24320 ENOG4105E5Q amino acid AbC transporter HUT09_RS24325 ENOG4105EAB amino acid AbC transporter HUT09_RS24330 ENOG4105C6K Malic enzyme HUT09_RS24335 ENOG4105CB2 alcohol dehydrogenase HUT09_RS24340 ENOG4105C4C beta-galactosidase HUT09_RS24355 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT09_RS24380 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT09_RS24385 ENOG4105EB3 Histidine kinase HUT09_RS24390 ENOG4108PYU two-component system response regulator HUT09_RS24410 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT09_RS24415 ENOG4108ZJ4 polysaccharide deacetylase HUT09_RS24420 ENOG4105XMC MarR family Transcriptional regulator HUT09_RS24430 ENOG4105BZU Histidine kinase HUT09_RS24455 ENOG4105ZXU NLP P60 protein HUT09_RS24470 ENOG41060BG Tetr family transcriptional regulator HUT09_RS24505 ENOG4105CJN penicillin-binding protein HUT09_RS24520 ENOG4108FKE two-component system sensor kinase HUT09_RS24540 ENOG4105DQE DNA ligase HUT09_RS24545 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT09_RS24590 ENOG4105C75 arginyL-tRNA synthetase HUT09_RS24595 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT09_RS24600 ENOG4105D6E homoserine dehydrogenase HUT09_RS24605 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT09_RS24610 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT09_RS24620 ENOG4108KGH TRANSCRIPTIONal HUT09_RS24625 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT09_RS24630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT09_RS24635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_RS24645 ENOG4107ZF2 Phosphatase HUT09_RS24660 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT09_RS24670 ENOG4105Z3P ATP synthase HUT09_RS24680 ENOG4105ZA1 atp synthase HUT09_RS24685 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT09_RS24690 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT09_RS24695 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT09_RS24700 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT09_RS24705 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT09_RS24710 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT09_RS24725 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS24735 ENOG4105IIP Membrane HUT09_RS24745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_RS24760 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT09_RS24815 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS24840 ENOG4105ETX regulatoR HUT09_RS24845 ENOG4105BZU Histidine kinase HUT09_RS24890 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT09_RS24910 ENOG4105WX6 Membrane HUT09_RS24920 ENOG4106R7G Glycoside hydrolase family 5 HUT09_RS24955 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT09_RS24960 ENOG4105C6K Malic enzyme HUT09_RS24965 ENOG4105CTQ phosphohexokinase HUT09_RS24975 ENOG4108MRH transcriptional regulatory protein HUT09_RS24980 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT09_RS24985 ENOG4105CK2 sodium dicarboxylate symporter HUT09_RS24995 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT09_RS25000 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT09_RS25005 ENOG4105CG3 alpha amylase, catalytic region HUT09_RS25010 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT09_RS25015 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT09_RS25050 ENOG4105BZ1 (ABC) transporter HUT09_RS25055 ENOG4105BZ1 (ABC) transporter HUT09_RS25060 ENOG4105CJ1 ABC, transporter HUT09_RS25075 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS25120 ENOG4105EBR Carboxylesterase HUT09_RS25160 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT09_RS25170 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT09_RS25175 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT09_RS25205 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT09_RS25220 ENOG4105C57 major facilitator superfamily HUT09_RS25230 ENOG4105CHR reductase HUT09_RS25365 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUT09_RS25415 ENOG4105BZW Glycerate kinase HUT09_RS25425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS25430 ENOG4106F60 Histidine kinase HUT09_RS25470 ENOG4105EJQ L-serine dehydratase HUT09_RS25475 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT09_RS25480 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT09_RS25485 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT09_RS25505 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT09_RS25510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_RS25515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS25520 ENOG4105C3U ABC transporter HUT09_RS25525 ENOG4108JQ7 (ABC) transporter HUT09_RS25530 ENOG4105EN6 Membrane HUT09_RS25565 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT09_RS25585 ENOG4105EMU Dehydrogenase HUT09_RS25595 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT09_RS25600 ENOG4105BZU Histidine kinase HUT09_RS25605 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT09_RS25610 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT09_RS25620 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT09_RS25625 ENOG4107R5R arsenical pump membrane protein HUT09_RS25630 ENOG4105HSS phospholipase C HUT09_RS25635 ENOG4105EYF MMPL domain protein HUT09_RS25660 ENOG4108FN7 Aldo keto reductase HUT09_RS25670 ENOG4105BZU Histidine kinase HUT09_RS25680 ENOG4108ZP8 Acetolactate synthase small subunit HUT09_RS25685 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT09_RS25690 ENOG4108JQ1 Dehydrogenase HUT09_RS25715 ENOG4107YHD transcriptional regulator HUT09_RS25725 ENOG4105C26 Dehydrogenase HUT09_RS25730 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT09_RS25745 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_RS25750 ENOG41080UQ Transcriptional regulator HUT09_RS25755 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT09_RS25760 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT09_RS25795 ENOG4105DWY Agmatine deiminase HUT09_RS25805 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT09_RS25810 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS25830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS25835 ENOG4105C3U ABC transporter HUT09_RS25865 ENOG41086D8 Transcriptional regulator HUT09_RS25890 ENOG4105C3M thioredoxin reductase HUT09_RS25900 ENOG4107WMG L,D-carboxypeptidase HUT09_RS25915 ENOG4105KVH Transcriptional regulator HUT09_RS25930 ENOG4105CH6 catalase HUT09_RS25940 ENOG4105DQ5 transport system permease protein HUT09_RS25945 ENOG4105TVJ transport system, permease HUT09_RS25950 ENOG4105E0A ABC, transporter HUT09_RS25985 ENOG4105ESP cell wall surface anchor family protein HUT09_RS25990 ENOG4105D8K carboxyl transferase HUT09_RS26010 ENOG4105GWZ Roadblock lc7 family protein HUT09_RS26030 ENOG4105GWZ Roadblock lc7 family protein HUT09_RS26045 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HUT09_RS26050 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT09_RS26085 ENOG41069M3 Transcriptional regulator HUT09_RS26090 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT09_RS26095 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT09_RS26105 ENOG4105K70 DNA-binding protein HUT09_RS26125 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT09_RS26130 ENOG4105CPF Cell wall formation (By similarity) HUT09_RS26145 ENOG4105DWF phosphomethylpyrimidine kinase HUT09_RS26150 ENOG4105VB9 50S ribosomal protein l28 HUT09_RS26155 ENOG4105DP4 dak2 domain fusion protein ylov HUT09_RS26160 ENOG4105CB5 ATP-dependent DNA helicase recG HUT09_RS26165 ENOG4106H78 methyltransferase HUT09_RS26170 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT09_RS26185 ENOG41084BZ 50S ribosomal protein L32 HUT09_RS26190 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT09_RS26195 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT09_RS26200 ENOG4105KVH Transcriptional regulator HUT09_RS26205 ENOG4105K4I Scp-like extracellular HUT09_RS26210 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT09_RS26220 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUT09_RS26260 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT09_RS26280 ENOG4105K5M 30s ribosomal protein S16 HUT09_RS26285 ENOG41082KU UPF0109 protein HUT09_RS26290 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT09_RS26295 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT09_RS26300 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT09_RS26315 ENOG4107QYR Signal peptidase i HUT09_RS26320 ENOG4107QYR Signal peptidase i HUT09_RS26335 ENOG41080R2 UPF0102 protein HUT09_RS26350 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS26365 ENOG4105CE9 30S ribosomal protein S2 HUT09_RS26370 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT09_RS26375 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT09_RS26380 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT09_RS26390 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT09_RS26400 ENOG4108I5D sulfate abc transporter HUT09_RS26420 ENOG4105C19 ABC transporter HUT09_RS26425 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT09_RS26435 ENOG4105C26 Dehydrogenase HUT09_RS26455 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT09_RS26460 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT09_RS26480 ENOG4107RUE extracellular solute-binding protein family 1 HUT09_RS26485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT09_RS26490 ENOG4105F38 ABC transporter, permease HUT09_RS26495 ENOG4105D38 putrescine abc transporter HUT09_RS26500 ENOG4105CJP fad dependent oxidoreductase HUT09_RS26530 ENOG4105G9B Transcriptional regulator HUT09_RS26535 ENOG4105C26 Dehydrogenase HUT09_RS26545 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUT09_RS26550 ENOG4105DZP Membrane-associated zinc metalloprotease HUT09_RS26555 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT09_RS26570 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT09_RS26590 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT09_RS26615 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT09_RS26620 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT09_RS26655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS26660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_RS26665 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT09_RS26690 ENOG4108T50 Protein of unknown function (DUF690) HUT09_RS26725 ENOG4105EC2 ftsk spoIIIe HUT09_RS26735 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT09_RS26740 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT09_RS26745 ENOG4105C1V Peptidase, M16 HUT09_RS26750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT09_RS26775 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT09_RS26780 ENOG4105CN5 Metallo-Beta-Lactamase HUT09_RS26810 ENOG4105BZU Histidine kinase HUT09_RS26815 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_RS26820 ENOG4107QZI cell division protein FtsK HUT09_RS26830 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT09_RS26840 ENOG4105CEV competence damage-inducible protein HUT09_RS26845 ENOG4105WBV Transcriptional regulator HUT09_RS26850 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT09_RS26860 ENOG4105CHR reductase HUT09_RS26865 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT09_RS26870 ENOG4107QRT dEAD DEAH box helicase HUT09_RS26875 ENOG4106AXJ AraC family transcriptional regulator HUT09_RS26905 ENOG4105CHR reductase HUT09_RS26910 ENOG4107SM8 Adenylate Guanylate cyclase HUT09_RS26915 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS26920 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT09_RS26950 ENOG4105DRP amino acid AbC transporter HUT09_RS26955 ENOG4105EAD ABC transporter HUT09_RS26960 ENOG4107UBR Extracellular solute-binding protein family 3 HUT09_RS26965 ENOG4105CDA abc transporter atp-binding protein HUT09_RS26970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS26975 ENOG4105EB3 Histidine kinase HUT09_RS26980 ENOG4105H1G trap transporter solute receptor taxi family HUT09_RS26985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT09_RS27000 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT09_RS27010 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT09_RS27015 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT09_RS27025 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT09_RS27065 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT09_RS27070 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT09_RS27075 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT09_RS27080 ENOG4108N5B 2-phosphosulfolactate phosphatase HUT09_RS27110 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT09_RS27125 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT09_RS27140 ENOG4105D5T phosphonate abc transporter HUT09_RS27145 ENOG4105C6F GntR Family Transcriptional Regulator HUT09_RS27150 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS27175 ENOG4107QN1 sodium solute HUT09_RS27180 ENOG4108MRH transcriptional regulatory protein HUT09_RS27185 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT09_RS27195 ENOG4105BZN citrate synthase HUT09_RS27200 ENOG4105BZN citrate synthase HUT09_RS27210 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT09_RS27230 ENOG4105DRR Transcriptional regulator, GntR family HUT09_RS27235 ENOG410849S phosphocarrier protein (HPr) HUT09_RS27240 ENOG4105CD5 CoA-binding domain protein HUT09_RS27255 ENOG4107W53 thymidine kinase HUT09_RS27290 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT09_RS27305 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT09_RS27310 ENOG4106F60 Histidine kinase HUT09_RS27335 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT09_RS27385 ENOG4107VEG TrkA-N domain protein HUT09_RS27390 ENOG4105C0X amino acid HUT09_RS27395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT09_RS27480 ENOG4106F1P AAA ATPase, central domain protein HUT09_RS27490 ENOG4105EC2 ftsk spoIIIe HUT09_RS27550 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT09_RS27555 ENOG4108IG5 Transcriptional regulator HUT09_RS27565 ENOG4105M4P Tetr family transcriptional regulator HUT09_RS27570 ENOG4105F27 Major Facilitator HUT09_RS27580 ENOG4105KHN chorismate mutase HUT09_RS27585 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT09_RS27595 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT09_RS27600 ENOG4105HHS UPF0256 protein HUT09_RS27635 ENOG4108IG5 Transcriptional regulator HUT09_RS27685 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT09_RS27690 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT09_RS27695 ENOG4105N14 lysine exporter protein LysE YggA HUT09_RS27700 ENOG4107SQD Transcriptional regulator, GntR family HUT09_RS27710 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT09_RS27755 ENOG4105DQ5 transport system permease protein HUT09_RS27760 ENOG4105TVJ transport system, permease HUT09_RS27790 ENOG4107T5V SNARE associated Golgi HUT09_RS27800 ENOG4105E98 transcriptional regulator DeoR family HUT09_RS27825 ENOG4107QK5 Homocysteine s-methyltransferase HUT09_RS27835 ENOG4107S1Q Phosphatase HUT09_RS27840 ENOG4105CEU Arginine dihydrolase HUT09_RS27845 ENOG4105DBV ornithine carbamoyltransferase HUT09_RS27850 ENOG4105CUB amino acid HUT09_RS27860 ENOG4105CGU Enoyl-CoA hydratase HUT09_RS27895 ENOG4105VR1 Pfam:DUF1271 HUT09_RS27900 ENOG4105D65 subunit l HUT09_RS27905 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT09_RS27910 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT09_RS27925 ENOG4105KJM monovalent cation h antiporter subunit g HUT09_RS27940 ENOG4106CD9 glycosyl transferase group 1 HUT09_RS27945 ENOG4108QV3 biosynthesis protein HUT09_RS27985 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT09_RS27990 ENOG4105C30 Nad-dependent epimerase dehydratase HUT09_RS27995 ENOG4105D3Q Sugar transferase HUT09_RS28025 ENOG410880H cysteine synthase HUT09_RS28035 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_RS28070 ENOG4107RIQ Sulfate adenylate transferase HUT09_RS28090 ENOG4108KB2 LysR family Transcriptional regulator HUT09_RS28100 ENOG4108KTG Membrane protein, drug metabolite transporter HUT09_RS28105 ENOG4105F27 Major Facilitator HUT09_RS28110 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT09_RS28135 ENOG4107QM5 aconitate hydratase HUT09_RS28145 ENOG4107TB6 phosphoglycerate mutase HUT09_RS28170 ENOG4105E2R ROK family HUT09_RS28175 ENOG4105DFW ABC transporter HUT09_RS28180 ENOG4105C2J ABC transporter HUT09_RS28185 ENOG4108HWW ABC transporter HUT09_RS28190 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT09_RS28195 ENOG4105CUB amino acid HUT09_RS28205 ENOG4108KGH TRANSCRIPTIONal HUT09_RS28215 ENOG4107SBE Glycosyl transferase (Group 1 HUT09_RS28220 ENOG4105C39 capsular polysaccharide phosphotransferase HUT09_RS28230 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT09_RS28235 ENOG4105C39 capsular polysaccharide phosphotransferase HUT09_RS28240 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_RS28245 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS28265 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT09_RS28270 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT09_RS28280 ENOG4105C1Q protoporphyrinogen oxidase HUT09_RS28285 ENOG4107JTW chlorite dismutase HUT09_RS28300 ENOG4105E18 UPF0276 protein HUT09_RS28380 ENOG4105DFU Cell wall formation (By similarity) HUT09_RS28385 ENOG4105E0X reductase HUT09_RS28440 ENOG4108MWI inositol mono-phosphatase HUT09_RS28450 ENOG4105ESN nucleotide-binding protein HUT09_RS28455 ENOG4108QZR synthase HUT09_RS28465 ENOG4105CPQ Dehydrogenase HUT09_RS28470 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT09_RS28475 ENOG4106NZI LysR family Transcriptional regulator HUT09_RS28485 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT09_RS28490 ENOG4107Z1W Fructose transport system kinase HUT09_RS28580 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS28595 ENOG4106JDR secreted HUT09_RS28605 ENOG4105BZ1 (ABC) transporter HUT09_RS28610 ENOG4105BZ1 (ABC) transporter HUT09_RS28615 ENOG4105MC2 DSBA oxidoreductase HUT09_RS28625 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_RS28630 ENOG4108IY8 ABC, transporter HUT09_RS28655 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT09_RS28675 ENOG4107RR1 TRANSCRIPTIONal HUT09_RS28680 ENOG4105CSU acyl-Coa dehydrogenase HUT09_RS28700 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_RS28715 ENOG4107RSM transcriptional regulator HUT09_RS28720 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS28765 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT09_RS28790 ENOG4105C7K acetolactate synthase HUT09_RS28815 ENOG4105DRR Transcriptional regulator, GntR family HUT09_RS28840 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT09_RS28845 ENOG4105C7N Xanthine uracil vitamin C permease HUT09_RS28850 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT09_RS28855 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT09_RS28890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT09_RS28905 ENOG4107SMB hydrolase Family 5 HUT09_RS28920 ENOG4105CHF Glutathione S-transferase HUT09_RS28945 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS28955 ENOG4105XYF acetyltransferase HUT09_RS28965 ENOG41060W2 glyoxylate carboligase HUT09_RS28990 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS29000 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT09_RS29015 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT09_RS29030 ENOG4105CH6 catalase HUT09_RS29035 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUT09_RS29040 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HUT09_RS29045 ENOG4106R7G Glycoside hydrolase family 5 HUT09_RS29050 ENOG4105E2D ec 3.2.1.52 HUT09_RS29070 ENOG4105FDP GntR family transcriptional regulator HUT09_RS29075 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT09_RS29095 ENOG4105VT2 5-hydroxyisourate hydrolase HUT09_RS29105 ENOG4105C2W permease HUT09_RS29110 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT09_RS29125 ENOG4105EV9 Alpha Beta Hydrolase HUT09_RS29150 ENOG4105CSX c4-dicarboxylate anaerobic carrier HUT09_RS29175 ENOG4107R9S Malate synthase HUT09_RS29190 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS29210 ENOG4107HP6 Transcriptional regulator HUT09_RS29225 ENOG4105CV8 reductase HUT09_RS29230 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT09_RS29255 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS29270 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT09_RS29285 ENOG4105CNN ABC, transporter HUT09_RS29290 ENOG4105C2J ABC transporter HUT09_RS29295 ENOG4105DKQ ROK family HUT09_RS29305 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT09_RS29310 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT09_RS29325 ENOG4105CHR reductase HUT09_RS29350 ENOG4105CDA abc transporter atp-binding protein HUT09_RS29355 ENOG4107UBR Extracellular solute-binding protein family 3 HUT09_RS29360 ENOG4105EAD ABC transporter HUT09_RS29365 ENOG4105DRP amino acid AbC transporter HUT09_RS29385 ENOG4105CAQ asparagine synthetase HUT09_RS29395 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUT09_RS29405 ENOG4108ES0 acetoacetyl-CoA synthetase HUT09_RS29425 ENOG4105CHR reductase HUT09_RS29435 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT09_RS29465 ENOG4107SET aldo keto reductase HUT09_RS29475 ENOG4105C8Y Acetylornithine aminotransferase HUT09_RS29480 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT09_RS29500 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUT09_RS29510 ENOG4105EGE secreted protein HUT09_RS29530 ENOG4105E9K Isocitrate dehydrogenase HUT09_RS29550 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HUT09_RS29560 ENOG4105CR4 methylisocitrate lyase HUT09_RS29570 ENOG4105CFF transcriptional regulator HUT09_RS29590 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS29595 ENOG4105C26 Dehydrogenase HUT09_RS29625 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS29640 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT09_RS29655 ENOG4105C10 Electron transfer flavoprotein HUT09_RS29695 ENOG4105CGU Enoyl-CoA hydratase HUT09_RS29715 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT09_RS29730 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT09_RS29735 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HUT09_RS29740 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS29745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS29755 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT09_RS29765 ENOG4105CIG ABC transporter HUT09_RS29770 ENOG4105E39 Enoyl-CoA hydratase HUT09_RS29775 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS29790 ENOG4108UVJ appr-1-p processing domain protein HUT09_RS29800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT09_RS29815 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT09_RS29830 ENOG4105BZW Glycerate kinase HUT09_RS29840 ENOG4108IV0 ABC, transporter HUT09_RS29845 ENOG4105C0Z ABC transporter HUT09_RS29850 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_RS29855 ENOG4105C32 Amino acid ABC transporter (Permease) HUT09_RS29900 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT09_RS29905 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS29915 ENOG4105CI0 Citrate lyase HUT09_RS29945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_RS29975 ENOG4108M0I Transcriptional regulator HUT09_RS29980 ENOG4105CPC Aldo Keto reductase HUT09_RS29990 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT09_RS29995 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT09_RS30005 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT09_RS30020 ENOG4105D9U N-acetyltransferase HUT09_RS30035 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT09_RS30055 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT09_RS30065 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS30080 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT09_RS30095 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT09_RS30105 ENOG4106GCT Dehydratase HUT09_RS30125 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT09_RS30135 ENOG4105CV8 reductase HUT09_RS30145 ENOG4107NQ8 LysR family Transcriptional regulator HUT09_RS30150 ENOG4105DHU Bile acid HUT09_RS30160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT09_RS30165 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS30175 ENOG4105C2J ABC transporter HUT09_RS30180 ENOG4105CNN ABC, transporter HUT09_RS30185 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT09_RS30210 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase HUT09_RS30270 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS30275 ENOG4105C2J ABC transporter HUT09_RS30280 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT09_RS30285 ENOG4108RVA ribokinase HUT09_RS30290 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HUT09_RS30300 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT09_RS30315 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HUT09_RS30330 ENOG4105BZU Histidine kinase HUT09_RS30335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT09_RS30370 ENOG4108IJ7 Glycine betaine HUT09_RS30375 ENOG4108HQS Glycine betaine HUT09_RS30385 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUT09_RS30395 ENOG4107WGA YidE YbjL HUT09_RS30410 ENOG4105CMG Carbohydrate kinase HUT09_RS30420 ENOG4105DKQ ROK family HUT09_RS30445 ENOG4105ME7 Membrane HUT09_RS30450 ENOG4108ZT1 Transcriptional regulator HUT09_RS30480 ENOG4106A3M Cytochrome p-450 HUT09_RS30485 ENOG4105F8D glycoside hydrolase family 4 HUT09_RS30525 ENOG4105K5B UPF0225 protein HUT09_RS30570 ENOG4105DHJ ABC, transporter HUT09_RS30660 ENOG4105CSR polyphosphate kinase 2 HUT09_RS30670 ENOG4105DQE DNA ligase HUT09_RS30715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT09_RS30725 ENOG4105GVF (ABC) transporter HUT09_RS30730 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT09_RS30740 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT09_RS30750 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT09_RS30760 ENOG41066F0 sporulation and cell division protein HUT09_RS30770 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT09_RS30780 ENOG4105EG6 Saccharopine dehydrogenase HUT09_RS30790 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS30795 ENOG4105CHU acetyl-coa acetyltransferase HUT09_RS30800 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT09_RS30830 ENOG4105C94 Transporter HUT09_RS30840 ENOG4105C5H ABC transporter HUT09_RS30845 ENOG4105BZM domain protein HUT09_RS30865 ENOG4105E39 Enoyl-CoA hydratase HUT09_RS30880 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT09_RS30910 ENOG4105D49 3-dehydroquinate synthase HUT09_RS30930 ENOG4105EY8 ABC transporter HUT09_RS30935 ENOG4105FBD synthase HUT09_RS30945 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT09_RS30955 ENOG4105EWU Squalene--hopene cyclase HUT09_RS30990 ENOG4105DR5 peptidase HUT09_RS30995 ENOG41090WU lipolytic protein G-D-S-L family HUT09_RS31045 ENOG410905P Pyridoxamine 5-phosphate HUT09_RS31085 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS31090 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HUT09_RS31100 ENOG4108IY8 ABC, transporter HUT09_RS31180 ENOG4105DXX methyltransferase HUT09_RS31245 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT09_RS31275 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS31280 ENOG4105BZU Histidine kinase HUT09_RS31290 ENOG4105C6F GntR Family Transcriptional Regulator HUT09_RS31295 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT09_RS31300 ENOG4107QR9 Iron-sulfur cluster binding protein HUT09_RS31305 ENOG41080R8 Conserved Protein HUT09_RS31325 ENOG4107SM8 Adenylate Guanylate cyclase HUT09_RS31335 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HUT09_RS31340 ENOG4105F6S Spore photoproduct lyase HUT09_RS31405 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT09_RS31435 ENOG4108TM9 integral membrane protein HUT09_RS31445 ENOG4105EMN RNA polymerase sigma factor HUT09_RS31455 ENOG4105ECQ AraC Family Transcriptional Regulator HUT09_RS31485 ENOG4105EWK phytoene HUT09_RS31490 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT09_RS31510 ENOG410650H (LipO)protein HUT09_RS31515 ENOG4105DBE peroxidase HUT09_RS31525 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT09_RS31540 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HUT09_RS31555 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT09_RS31565 ENOG4105EZR dyp-type peroxidase family protein HUT09_RS31570 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT09_RS31585 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT09_RS31590 ENOG4105EBR Carboxylesterase HUT09_RS31595 ENOG4107TXC Transcriptional regulator HUT09_RS31615 ENOG4106T9R serine protease HUT09_RS31640 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT09_RS31655 ENOG4105E2R ROK family HUT09_RS31660 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS31665 ENOG4105MS9 Resuscitation-promoting factor HUT09_RS31705 ENOG4105BZU Histidine kinase HUT09_RS31710 ENOG4107YTP response regulator receiver protein HUT09_RS31715 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS31770 ENOG4108NEV two component transcriptional regulator, LytTR family HUT09_RS31785 ENOG4108HRK Histidine kinase HUT09_RS31855 ENOG4105BZU Histidine kinase HUT09_RS31860 ENOG4105DND Transcriptional regulator HUT09_RS31875 ENOG4105E33 succinate dehydrogenase HUT09_RS31885 ENOG4105DEN Luciferase family HUT09_RS31895 ENOG4105WKW Pfam:DUF1458 HUT09_RS31915 ENOG41067HS methyltransferase HUT09_RS31920 ENOG4108V75 Glutamine amidotransferase HUT09_RS31925 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT09_RS31930 ENOG4105D1K glutamate--cysteine ligase HUT09_RS31950 ENOG41080RH Thioredoxin HUT09_RS31955 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT09_RS31960 ENOG4105CSV Glutaminase HUT09_RS31965 ENOG4107QPH glycogen) synthase HUT09_RS31970 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT09_RS31980 ENOG4105C57 major facilitator superfamily HUT09_RS32025 ENOG4108W6C Dehydrogenase HUT09_RS32030 ENOG4105CF7 AraC family transcriptional regulator HUT09_RS32045 ENOG4105CHR reductase HUT09_RS32060 ENOG4105CIK Amidinotransferase HUT09_RS32115 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT09_RS32135 ENOG4105EUB pirin domain protein HUT09_RS32160 ENOG4105R1U AraC Family Transcriptional Regulator HUT09_RS32165 ENOG4105EU0 Major facilitator Superfamily HUT09_RS32190 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_RS32200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS32205 ENOG4105C3U ABC transporter HUT09_RS32210 ENOG4108JQ7 (ABC) transporter HUT09_RS32220 ENOG4107SCK Monooxygenase HUT09_RS32250 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS32255 ENOG4105D4B ABC, transporter HUT09_RS32260 ENOG4105F5R ABC transporter HUT09_RS32265 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT09_RS32270 ENOG4105C2J ABC transporter HUT09_RS32285 ENOG4105DET Rhamnulokinase HUT09_RS32295 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUT09_RS32300 ENOG4105J76 Periplasmic binding protein HUT09_RS32305 ENOG4105E0A ABC, transporter HUT09_RS32320 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT09_RS32330 ENOG4105NRA 50s ribosomal protein l31 type b HUT09_RS32335 ENOG4105W0E 50S ribosomal protein L33 HUT09_RS32340 ENOG4105KDC 50s ribosomal protein l28 HUT09_RS32345 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT09_RS32350 ENOG41068HZ 50S ribosomal protein L32 HUT09_RS32365 ENOG4108U1V ABC transporter, permease HUT09_RS32370 ENOG4105DQ5 transport system permease protein HUT09_RS32375 ENOG4105E0A ABC, transporter HUT09_RS32405 ENOG4105BZ1 (ABC) transporter HUT09_RS32450 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_RS32460 ENOG4105CJR Integral membrane protein (MviN HUT09_RS32470 ENOG4105D3Q Sugar transferase HUT09_RS32500 ENOG4105E90 ABC transporter HUT09_RS32505 ENOG4105E90 ABC transporter HUT09_RS32520 ENOG4108IJ8 ABC transporter HUT09_RS32530 ENOG4108V62 Rhodanese domain protein HUT09_RS32545 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT09_RS32550 ENOG4105D2B acyl-CoA dehydrogenase HUT09_RS32555 ENOG4105D2B acyl-CoA dehydrogenase HUT09_RS32575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS32580 ENOG4105C3U ABC transporter HUT09_RS32585 ENOG4108JQ7 (ABC) transporter HUT09_RS32645 ENOG4105DCG PHP domain protein HUT09_RS32735 ENOG4105VEQ Cold shock protein HUT09_RS32750 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT09_RS32755 ENOG4108Z0Z intracellular protease Pfpi family HUT09_RS32765 ENOG4105CQS hydrogenase expression formation protein HypD HUT09_RS32785 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT09_RS32790 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT09_RS32835 ENOG41065HY 1,4-beta-cellobiosidase HUT09_RS32840 ENOG4105E2B Taurine dioxygenase HUT09_RS32850 ENOG4105ETE Transcriptional regulator (LacI family HUT09_RS32905 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT09_RS32925 ENOG4105C26 Dehydrogenase HUT09_RS32930 ENOG4107RR1 TRANSCRIPTIONal HUT09_RS32945 ENOG4105C0D helicase HUT09_RS33000 ENOG41082SX arsR family transcriptional regulator HUT09_RS33015 ENOG4105GWZ Roadblock lc7 family protein HUT09_RS33040 ENOG4105E39 Enoyl-CoA hydratase HUT09_RS33075 ENOG4105VBF alkaline shock protein HUT09_RS33080 ENOG4105EMN RNA polymerase sigma factor HUT09_RS33095 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HUT09_RS33100 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT09_RS33115 ENOG4105K4I Scp-like extracellular HUT09_RS33125 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT09_RS33145 ENOG4106NZI LysR family Transcriptional regulator HUT09_RS33160 ENOG4107JC6 Membrane HUT09_RS33165 ENOG4105C5H ABC transporter HUT09_RS33190 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUT09_RS33245 ENOG4105CVN desaturase HUT09_RS33280 ENOG4108Z6Z Transcriptional regulator HUT09_RS33285 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT09_RS33300 ENOG4105I9Z UPF0264 protein HUT09_RS33310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_RS33360 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT09_RS33365 ENOG4105C5I Dehydrogenase HUT09_RS33370 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT09_RS33380 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT09_RS33405 ENOG4106NZI LysR family Transcriptional regulator HUT09_RS33475 ENOG4105EMU Dehydrogenase HUT09_RS33510 ENOG4105ERH Fumarylacetoacetate hydrolase HUT09_RS33515 ENOG4105CEY Amp-dependent synthetase and ligase HUT09_RS33530 ENOG4105C57 major facilitator superfamily HUT09_RS33550 ENOG4105C26 Dehydrogenase HUT09_RS33595 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS33605 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT09_RS33640 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT09_RS33670 ENOG4105WN5 stage II sporulation protein HUT09_RS33705 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT09_RS33720 ENOG4105MHT Transcriptional regulator, ARSR family HUT09_RS33755 ENOG4105E0A ABC, transporter HUT09_RS33760 ENOG4105CC5 ABC transporter HUT09_RS33800 ENOG4105VNT transposase (IS4 family) protein HUT09_RS33845 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT09_RS33990 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT09_RS34040 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS34205 ENOG4105CHH sulfate transporter HUT09_RS34215 ENOG4105EUZ Beta-lactamase domain protein HUT09_RS34335 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT09_RS34340 ENOG4108Y6J UPF0403 protein HUT09_RS34350 ENOG4107QPD alcohol dehydrogenase HUT09_RS34355 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUT09_RS34360 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUT09_RS34415 ENOG4105VNT transposase (IS4 family) protein HUT09_RS34485 ENOG4107QQG Dehydrogenase HUT09_RS34495 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT09_RS34510 ENOG4105DXX methyltransferase HUT09_RS34525 ENOG4105CV8 reductase HUT09_RS34590 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT09_RS34610 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT09_RS34660 ENOG4105CUB amino acid HUT09_RS34685 ENOG4105EYF MMPL domain protein HUT09_RS34690 ENOG4105BZU Histidine kinase HUT09_RS34695 ENOG4105WH1 Two component transcriptional regulator luxr family HUT09_RS34715 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT09_RS34760 ENOG4105EIP mannose-6-phosphate isomerase HUT09_RS34780 ENOG4105DRS transport system, permease HUT09_RS34840 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT09_RS34880 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS34940 ENOG4105CBC glutamate synthase HUT09_RS34945 ENOG4105C7K acetolactate synthase HUT09_RS34950 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT09_RS34970 ENOG4107R6F Alpha Beta Hydrolase Fold protein HUT09_RS34980 ENOG4105WN5 stage II sporulation protein HUT09_RS34990 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT09_RS35010 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT09_RS35020 ENOG4107MMM Anti-sigma-factor antagonist HUT09_RS35065 ENOG4105VEQ Cold shock protein HUT09_RS35070 ENOG4105C1J atp-dependent rna helicase HUT09_RS35180 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT09_RS35205 ENOG4108KB2 LysR family Transcriptional regulator HUT09_RS35210 ENOG4105F27 Major Facilitator HUT09_RS35225 ENOG4108M9J MaoC like domain protein HUT09_RS35235 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_RS35240 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_RS35245 ENOG4105CAQ asparagine synthetase HUT09_RS35260 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT09_RS35280 ENOG4105BZ1 (ABC) transporter HUT09_RS35320 ENOG4105C1G acyl-Coa dehydrogenase HUT09_RS35335 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT09_RS35420 ENOG4105MP0 transposase HUT09_RS35460 ENOG4105CKK Glycosyl transferase, family 2 HUT09_RS35515 ENOG4105D5G Transposase HUT09_RS35540 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT09_RS35545 ENOG4108JQ7 (ABC) transporter HUT09_RS35555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT09_RS35560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT09_RS35565 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT09_RS35570 ENOG4107T6F Xaa-Pro aminopeptidase HUT09_RS35575 ENOG4105DRR Transcriptional regulator, GntR family HUT09_RS35580 ENOG4105CIF Ornithine Cyclodeaminase HUT09_RS35585 ENOG4105CTU Proline racemase HUT09_RS35590 ENOG4105CTU Proline racemase HUT09_RS35610 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT09_RS35690 ENOG4108HMN Caspase domain HUT09_RS35780 ENOG4105CPC Aldo Keto reductase HUT09_RS35785 ENOG4106448 streptomycin biosynthesis protein strI HUT09_RS35800 ENOG4108W6C Dehydrogenase HUT09_RS35830 ENOG4105WQT MbtH domain protein HUT09_RS35865 ENOG4105PTV Nudix Hydrolase HUT09_RS35880 ENOG4105MP0 transposase HUT09_RS35935 ENOG41065KQ synthase HUT09_RS35945 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT09_RS35990 ENOG4105CFG Acts as a chaperone (By similarity) HUT09_RS36050 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HUT09_RS36055 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HUT09_RS36075 ENOG4105FB9 CRISPR-associated protein HUT09_RS36205 ENOG4105CPC Aldo Keto reductase HUT09_RS36260 ENOG4108RWI nicotinamidase HUT09_RS36325 ENOG4105CH6 catalase HUT09_RS36385 ENOG4107QJE Chromosome Partitioning Protein HUT09_RS36415 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT09_RS36425 ENOG4105KAV tspo and mbr like protein HUT09_RS36445 ENOG4105C0B DNA polymerase III (alpha subunit) HUT09_RS36460 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT09_RS36625 ENOG410836F Transposase HUT09_RS36640 ENOG4105CYP glycoside hydrolase, family HUT09_RS36690 ENOG4105CV8 reductase HUT09_RS36700 ENOG4105KVH Transcriptional regulator HUT09_RS36835 ENOG4108KEZ Dehydrogenase HUT09_RS36840 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT09_RS36895 ENOG4105CHH sulfate transporter HUT09_RS36905 ENOG4105EUZ Beta-lactamase domain protein HUT09_RS36960 ENOG4105CDU Replicative dna helicase HUT09_RS37030 ENOG4105FA0 parb-like partition protein HUT09_RS37135 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)