locus-tag	class	description
CP966_RS00010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP966_RS00030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP966_RS00035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP966_RS00045	COG1116	anion transmembrane transporter activity
CP966_RS00070	COG0789	Transcriptional regulator
CP966_RS00080	COG1874	Beta-galactosidase
CP966_RS00080	COG0366	Alpha amylase catalytic
CP966_RS00100	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS00105	COG2130	NADP-dependent
CP966_RS00150	COG2249	NAD(P)H dehydrogenase (quinone) activity
CP966_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS00180	COG0523	cobalamin synthesis protein
CP966_RS00190	COG0443	Heat shock 70 kDa protein
CP966_RS00205	COG0730	response to heat
CP966_RS00220	COG0488	(ABC) transporter
CP966_RS00250	COG2045	Belongs to the ComB family
CP966_RS00255	COG1733	regulation of RNA biosynthetic process
CP966_RS00275	COG0024	Methionine aminopeptidase
CP966_RS00320	COG0346	lactoylglutathione lyase activity
CP966_RS00325	COG0640	Transcriptional regulator
CP966_RS00335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP966_RS00395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP966_RS00425	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CP966_RS00435	COG4213	ABC transporter substrate-binding protein
CP966_RS00470	COG2080	2 iron, 2 sulfur cluster binding
CP966_RS00475	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP966_RS00480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP966_RS00490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP966_RS00520	COG2814	Major facilitator Superfamily
CP966_RS00545	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CP966_RS00550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP966_RS00595	COG0596	Alpha beta hydrolase
CP966_RS00655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP966_RS00670	COG2382	esterase
CP966_RS00675	COG1132	(ABC) transporter
CP966_RS00685	COG1132	(ABC) transporter
CP966_RS00690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CP966_RS00695	COG1120	ATPase activity
CP966_RS00700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS00705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS00710	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP966_RS00755	COG2226	methyltransferase
CP966_RS00760	COG2409	Drug exporters of the RND superfamily
CP966_RS00770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP966_RS00785	COG0517	IMP dehydrogenase activity
CP966_RS00795	COG1881	PFAM PEBP family protein
CP966_RS00810	COG0589	response to stress
CP966_RS00850	COG1653	transport
CP966_RS00865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS00885	COG1278	Cold shock
CP966_RS00900	COG3896	Chloramphenicol phosphotransferase-like protein
CP966_RS00910	COG1595	DNA-templated transcription, initiation
CP966_RS00945	COG0740	serine-type endopeptidase activity
CP966_RS00950	COG0740	serine-type endopeptidase activity
CP966_RS00955	COG1396	sequence-specific DNA binding
CP966_RS00960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP966_RS00965	COG1191	sigma factor activity
CP966_RS00995	COG1716	ATPase activity
CP966_RS00995	COG1131	(ABC) transporter
CP966_RS00995	COG0842	Transport permease protein
CP966_RS01015	COG0667	Aldo Keto reductase
CP966_RS01020	COG0583	DNA-binding transcription factor activity
CP966_RS01030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP966_RS01035	COG0346	lactoylglutathione lyase activity
CP966_RS01050	COG0667	Aldo Keto reductase
CP966_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS01105	COG4941	Belongs to the sigma-70 factor family
CP966_RS01120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS01130	COG0431	NADPH-dependent FMN reductase
CP966_RS01155	COG2409	Drug exporters of the RND superfamily
CP966_RS01160	COG1846	Transcriptional regulator
CP966_RS01165	COG0702	epimerase
CP966_RS01195	COG0640	Transcriptional regulator
CP966_RS01200	COG0596	Alpha beta hydrolase
CP966_RS01235	COG0069	glutamate synthase activity
CP966_RS01250	COG3320	Male sterility
CP966_RS01250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP966_RS01260	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS01270	COG0673	inositol 2-dehydrogenase activity
CP966_RS01330	COG1024	Enoyl-CoA hydratase
CP966_RS01350	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS01360	COG1846	Transcriptional regulator
CP966_RS01365	COG2366	antibiotic biosynthetic process
CP966_RS01375	COG2070	2-Nitropropane dioxygenase
CP966_RS01415	COG1960	acyl-CoA dehydrogenase activity
CP966_RS01435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP966_RS01455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CP966_RS01495	COG0640	Transcriptional regulator
CP966_RS01545	COG1024	Enoyl-CoA hydratase
CP966_RS01545	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP966_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS01565	COG0300	oxidoreductase activity
CP966_RS01570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP966_RS01575	COG0596	Alpha beta hydrolase
CP966_RS01610	COG2315	Protein conserved in bacteria
CP966_RS01620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP966_RS01625	COG0745	RESPONSE REGULATOR receiver
CP966_RS01685	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CP966_RS01690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CP966_RS01695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CP966_RS01755	COG1063	alcohol dehydrogenase
CP966_RS01770	COG2376	Dihydroxyacetone kinase
CP966_RS01775	COG1461	Dihydroxyacetone kinase
CP966_RS01815	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP966_RS01815	COG1902	pentaerythritol trinitrate reductase activity
CP966_RS01835	COG2890	protein-(glutamine-N5) methyltransferase activity
CP966_RS01850	COG4221	oxidoreductase activity
CP966_RS01850	COG3321	synthase
CP966_RS01850	COG0604	alcohol dehydrogenase
CP966_RS01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP966_RS01855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP966_RS01860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP966_RS01870	COG3458	cephalosporin-C deacetylase activity
CP966_RS01875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP966_RS01880	COG2188	Transcriptional regulator
CP966_RS01885	COG2226	methyltransferase
CP966_RS01890	COG1695	Transcriptional regulator
CP966_RS01910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CP966_RS01925	COG5650	phosphatidylinositol metabolic process
CP966_RS01935	COG2066	Belongs to the glutaminase family
CP966_RS01950	COG1113	amino acid transport
CP966_RS01955	COG2186	Transcriptional regulator
CP966_RS01960	COG1968	undecaprenyl-diphosphatase activity
CP966_RS01965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP966_RS01970	COG1993	acr, cog1993
CP966_RS01975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP966_RS01985	COG0640	Transcriptional regulator
CP966_RS02005	COG1175	transmembrane transport
CP966_RS02010	COG0395	ABC-type sugar transport system, permease component
CP966_RS02050	COG0477	Major facilitator Superfamily
CP966_RS02100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP966_RS02110	COG2409	Drug exporters of the RND superfamily
CP966_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS02210	COG1609	Transcriptional regulator
CP966_RS02225	COG0395	ABC-type sugar transport system, permease component
CP966_RS02240	COG1595	DNA-templated transcription, initiation
CP966_RS02275	COG2268	Band 7 protein
CP966_RS02290	COG3507	Belongs to the glycosyl hydrolase 43 family
CP966_RS02300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP966_RS02305	COG1121	(ABC) transporter
CP966_RS02315	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP966_RS02330	COG2197	response regulator
CP966_RS02355	COG2755	lipolytic protein G-D-S-L family
CP966_RS02375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP966_RS02385	COG1595	DNA-templated transcription, initiation
CP966_RS02420	COG0477	Major facilitator Superfamily
CP966_RS02450	COG1846	Transcriptional regulator
CP966_RS02470	COG0778	Nitroreductase
CP966_RS02490	COG1672	PFAM Archaeal ATPase
CP966_RS02490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP966_RS02505	COG1672	PFAM Archaeal ATPase
CP966_RS02505	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP966_RS02540	COG0477	Major facilitator Superfamily
CP966_RS02560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP966_RS02580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP966_RS02620	COG1595	DNA-templated transcription, initiation
CP966_RS02625	COG1764	response to oxidative stress
CP966_RS02635	COG1053	succinate dehydrogenase
CP966_RS02655	COG1595	DNA-templated transcription, initiation
CP966_RS02865	COG1752	Esterase of the alpha-beta hydrolase superfamily
CP966_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS03000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CP966_RS03005	COG1215	transferase activity, transferring glycosyl groups
CP966_RS03030	COG0464	growth
CP966_RS03040	COG1349	DNA-binding transcription factor activity
CP966_RS03065	COG0577	efflux transmembrane transporter activity
CP966_RS03070	COG1136	(ABC) transporter
CP966_RS03095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP966_RS03105	COG1940	carbohydrate kinase activity
CP966_RS03115	COG2813	Specifically methylates the guanine in position
CP966_RS03125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP966_RS03130	COG1349	DNA-binding transcription factor activity
CP966_RS03160	COG2197	response regulator
CP966_RS03165	COG4585	Histidine kinase
CP966_RS03180	COG0445	tRNA wobble uridine modification
CP966_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP966_RS03200	COG1660	Displays ATPase and GTPase activities
CP966_RS03240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP966_RS03265	COG0204	Acyl-transferase
CP966_RS03300	COG0584	glycerophosphoryl diester phosphodiesterase
CP966_RS03320	COG0667	Aldo Keto reductase
CP966_RS03335	COG0671	phosphoesterase, PA-phosphatase related
CP966_RS03355	COG1309	transcriptional regulator
CP966_RS03380	COG2233	PERMEase
CP966_RS03385	COG0640	Transcriptional regulator
CP966_RS03390	COG1902	pentaerythritol trinitrate reductase activity
CP966_RS03400	COG3509	depolymerase
CP966_RS03415	COG1960	acyl-CoA dehydrogenase activity
CP966_RS03480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP966_RS03520	COG1278	Cold shock
CP966_RS03540	COG0714	Associated with various cellular activities
CP966_RS03555	COG2318	DinB family
CP966_RS03575	COG0714	Associated with various cellular activities
CP966_RS03600	COG1733	regulation of RNA biosynthetic process
CP966_RS03625	COG0492	ferredoxin-NADP+ reductase activity
CP966_RS03635	COG1132	(ABC) transporter
CP966_RS03645	COG1301	dicarboxylic acid transport
CP966_RS03655	COG1132	(ABC) transporter
CP966_RS03660	COG1132	(ABC) transporter
CP966_RS03670	COG0254	rRNA binding
CP966_RS03685	COG1946	Acyl-CoA thioesterase
CP966_RS03695	COG2018	Roadblock/LC7 domain
CP966_RS03765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP966_RS03795	COG1846	Transcriptional regulator
CP966_RS03795	COG1940	carbohydrate kinase activity
CP966_RS03810	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS03820	COG0309	Hydrogenase expression formation protein (HypE)
CP966_RS03830	COG0298	carbon dioxide binding
CP966_RS03835	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CP966_RS03840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP966_RS03845	COG0375	protein maturation
CP966_RS03885	COG1024	Enoyl-CoA hydratase
CP966_RS03885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP966_RS03915	COG3344	reverse transcriptase
CP966_RS03975	COG3693	PFAM glycoside hydrolase, family 10
CP966_RS03995	COG0202	RNA polymerase activity
CP966_RS04085	COG1231	oxidoreductase activity
CP966_RS04090	COG1090	epimerase
CP966_RS04110	COG3629	intracellular signal transduction
CP966_RS04110	COG3903	Transcriptional regulator
CP966_RS04115	COG3903	Transcriptional regulator
CP966_RS04115	COG3629	intracellular signal transduction
CP966_RS04140	COG1295	ribonuclease BN
CP966_RS04170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP966_RS04175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP966_RS04180	COG0601	transmembrane transport
CP966_RS04185	COG0747	negative chemotaxis
CP966_RS04200	COG4948	Mandelate Racemase Muconate Lactonizing
CP966_RS04205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP966_RS04215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP966_RS04250	COG0662	Cupin 2, conserved barrel domain protein
CP966_RS04260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP966_RS04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP966_RS04290	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CP966_RS04310	COG3766	membrane
CP966_RS04315	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP966_RS04320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP966_RS04325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP966_RS04335	COG0789	Transcriptional regulator
CP966_RS04360	COG1960	acyl-CoA dehydrogenase activity
CP966_RS04365	COG1960	acyl-CoA dehydrogenase activity
CP966_RS04380	COG3634	alkyl hydroperoxide reductase activity
CP966_RS04385	COG1793	dna ligase
CP966_RS04405	COG1960	acyl-CoA dehydrogenase activity
CP966_RS04415	COG0242	peptide deformylase activity
CP966_RS04425	COG3442	glutamine amidotransferase
CP966_RS04430	COG0205	6-phosphofructokinase activity
CP966_RS04445	COG3275	phosphorelay sensor kinase activity
CP966_RS04450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP966_RS04460	COG3279	Response regulator of the LytR AlgR family
CP966_RS04465	COG1522	sequence-specific DNA binding
CP966_RS04470	COG1834	amidinotransferase
CP966_RS04475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP966_RS04500	COG0829	nickel cation binding
CP966_RS04505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP966_RS04515	COG0804	urea catabolic process
CP966_RS04520	COG0832	Belongs to the urease beta subunit family
CP966_RS04525	COG0831	urea catabolic process
CP966_RS04530	COG1309	transcriptional regulator
CP966_RS04545	COG0740	serine-type endopeptidase activity
CP966_RS04555	COG0791	NLP P60 protein
CP966_RS04580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP966_RS04585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP966_RS04590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP966_RS04600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CP966_RS04605	COG2226	methyltransferase
CP966_RS04620	COG1136	(ABC) transporter
CP966_RS04620	COG0577	efflux transmembrane transporter activity
CP966_RS04625	COG0577	efflux transmembrane transporter activity
CP966_RS04650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP966_RS04655	COG3663	DNA glycosylase
CP966_RS04675	COG4585	Histidine kinase
CP966_RS04680	COG2197	response regulator
CP966_RS04685	COG1940	carbohydrate kinase activity
CP966_RS04695	COG1595	DNA-templated transcription, initiation
CP966_RS04710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP966_RS04725	COG0626	cystathionine gamma-synthase activity
CP966_RS04745	COG1522	sequence-specific DNA binding
CP966_RS04750	COG0419	ATPase involved in DNA repair
CP966_RS04755	COG0420	3'-5' exonuclease activity
CP966_RS04775	COG1739	Uncharacterized protein family UPF0029
CP966_RS04785	COG0215	cysteine-tRNA ligase activity
CP966_RS04790	COG1832	CoA-binding protein
CP966_RS04815	COG0110	maltose O-acetyltransferase activity
CP966_RS04860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP966_RS04875	COG0183	Belongs to the thiolase family
CP966_RS04895	COG1968	undecaprenyl-diphosphatase activity
CP966_RS04945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP966_RS04960	COG2318	DinB family
CP966_RS04975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP966_RS05025	COG0697	spore germination
CP966_RS05065	COG1695	Transcriptional regulator
CP966_RS05105	COG0384	phenazine biosynthesis protein PhzF
CP966_RS05130	COG1609	Transcriptional regulator
CP966_RS05140	COG0395	ABC-type sugar transport system, permease component
CP966_RS05145	COG1175	transmembrane transport
CP966_RS05180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP966_RS05180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP966_RS05195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP966_RS05215	COG1716	ATPase activity
CP966_RS05235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP966_RS05270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP966_RS05280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP966_RS05295	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CP966_RS05315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP966_RS05320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP966_RS05355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP966_RS05360	COG2146	nitrite reductase [NAD(P)H] activity
CP966_RS05365	COG1414	Transcriptional regulator
CP966_RS05385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP966_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS05400	COG0531	amino acid
CP966_RS05430	COG2814	Major facilitator Superfamily
CP966_RS05435	COG4336	lyase activity
CP966_RS05440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CP966_RS05445	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CP966_RS05450	COG1984	allophanate hydrolase subunit 2
CP966_RS05455	COG2755	lipolytic protein G-D-S-L family
CP966_RS05460	COG0438	transferase activity, transferring glycosyl groups
CP966_RS05465	COG0438	transferase activity, transferring glycosyl groups
CP966_RS05495	COG2364	Membrane
CP966_RS05505	COG2270	Major facilitator Superfamily
CP966_RS05520	COG1216	Glycosyl transferase, family 2
CP966_RS05545	COG1960	acyl-CoA dehydrogenase activity
CP966_RS05570	COG0237	dephospho-CoA kinase activity
CP966_RS05595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP966_RS05600	COG0140	phosphoribosyl-ATP diphosphatase activity
CP966_RS05605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP966_RS05610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP966_RS05610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP966_RS05615	COG3201	nicotinamide mononucleotide transporter
CP966_RS05630	COG1940	carbohydrate kinase activity
CP966_RS05630	COG1846	Transcriptional regulator
CP966_RS05635	COG2223	nitrite transmembrane transporter activity
CP966_RS05650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP966_RS05665	COG0531	amino acid
CP966_RS05685	COG2390	Transcriptional regulator
CP966_RS05690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP966_RS05700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP966_RS05715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP966_RS05725	COG1758	RNA polymerase activity
CP966_RS05730	COG0194	GDP metabolic process
CP966_RS05740	COG0284	orotidine-5'-phosphate decarboxylase activity
CP966_RS05745	COG0167	dihydroorotate dehydrogenase activity
CP966_RS05750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP966_RS05755	COG0505	Belongs to the CarA family
CP966_RS05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP966_RS05770	COG0540	Belongs to the ATCase OTCase family
CP966_RS05775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CP966_RS05785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP966_RS05790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP966_RS05795	COG0006	proline dipeptidase activity
CP966_RS05805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP966_RS05810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP966_RS05815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP966_RS05820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP966_RS05825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP966_RS05835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP966_RS05840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP966_RS05855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP966_RS05870	COG0124	histidyl-tRNA synthetase
CP966_RS05880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CP966_RS05885	COG1196	nuclear chromosome segregation
CP966_RS05900	COG0515	serine threonine protein kinase
CP966_RS05905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP966_RS05910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP966_RS05915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP966_RS05920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP966_RS05930	COG2255	four-way junction helicase activity
CP966_RS05935	COG0632	four-way junction helicase activity
CP966_RS05940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP966_RS05945	COG0217	transcriptional regulatory protein
CP966_RS05950	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CP966_RS05955	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CP966_RS05965	COG0438	transferase activity, transferring glycosyl groups
CP966_RS05970	COG1560	Kdo2-lipid A biosynthetic process
CP966_RS05975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP966_RS05995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP966_RS06000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP966_RS06015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP966_RS06045	COG0395	ABC-type sugar transport system, permease component
CP966_RS06050	COG1175	transmembrane transport
CP966_RS06055	COG1653	transport
CP966_RS06105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP966_RS06165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP966_RS06165	COG1648	precorrin-2 dehydrogenase activity
CP966_RS06170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP966_RS06185	COG1464	Belongs to the NlpA lipoprotein family
CP966_RS06190	COG2011	ABC-type metal ion transport system permease component
CP966_RS06195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP966_RS06220	COG0584	glycerophosphoryl diester phosphodiesterase
CP966_RS06225	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS06225	COG0204	Acyl-transferase
CP966_RS06230	COG0477	Major facilitator Superfamily
CP966_RS06245	COG0165	Argininosuccinate lyase
CP966_RS06265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP966_RS06265	COG1017	nitric oxide dioxygenase activity
CP966_RS06280	COG1438	arginine binding
CP966_RS06285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP966_RS06290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP966_RS06295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP966_RS06300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP966_RS06335	COG0697	spore germination
CP966_RS06345	COG1649	PFAM Uncharacterised BCR, COG1649
CP966_RS06370	COG0072	phenylalanine-tRNA ligase activity
CP966_RS06370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP966_RS06375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP966_RS06380	COG5002	protein histidine kinase activity
CP966_RS06385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP966_RS06390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP966_RS06395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP966_RS06400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP966_RS06450	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS06455	COG0174	glutamine synthetase
CP966_RS06465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CP966_RS06495	COG4176	ABC-type proline glycine betaine transport system permease component
CP966_RS06500	COG0517	IMP dehydrogenase activity
CP966_RS06500	COG4175	Glycine betaine
CP966_RS06505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP966_RS06540	COG0564	pseudouridine synthase activity
CP966_RS06570	COG1309	transcriptional regulator
CP966_RS06600	COG0805	protein transport
CP966_RS06605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP966_RS06635	COG0545	Peptidyl-prolyl cis-trans isomerase
CP966_RS06640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP966_RS06650	COG1609	Transcriptional regulator
CP966_RS06655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP966_RS06660	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP966_RS06675	COG4122	O-methyltransferase activity
CP966_RS06680	COG1222	aaa ATPase
CP966_RS06705	COG1994	Peptidase M50
CP966_RS06705	COG0517	IMP dehydrogenase activity
CP966_RS06715	COG2197	response regulator
CP966_RS06720	COG4166	transmembrane transport
CP966_RS06725	COG0747	negative chemotaxis
CP966_RS06735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP966_RS06740	COG1410	methionine synthase
CP966_RS06740	COG0646	methionine synthase
CP966_RS06745	COG1414	Transcriptional regulator
CP966_RS06750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP966_RS06755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP966_RS06760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP966_RS06765	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CP966_RS06775	COG1129	ABC transporter
CP966_RS06780	COG1879	ABC-type sugar transport system periplasmic component
CP966_RS06785	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CP966_RS06790	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CP966_RS06795	COG0235	Class ii aldolase
CP966_RS06800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CP966_RS06800	COG0235	Class ii aldolase
CP966_RS06810	COG0215	cysteine-tRNA ligase activity
CP966_RS06825	COG0406	alpha-ribazole phosphatase activity
CP966_RS06830	COG0598	Magnesium transport protein CorA
CP966_RS06840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS06845	COG0667	Aldo Keto reductase
CP966_RS06875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP966_RS06890	COG0308	aminopeptidase N
CP966_RS06895	COG3012	SEC-C Motif Domain Protein
CP966_RS06900	COG2186	Transcriptional regulator
CP966_RS06905	COG3265	gluconokinase activity
CP966_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS06920	COG1063	alcohol dehydrogenase
CP966_RS06945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP966_RS06950	COG2149	membrane
CP966_RS06975	COG1960	acyl-CoA dehydrogenase activity
CP966_RS06985	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS06995	COG3876	Protein conserved in bacteria
CP966_RS07020	COG0789	Transcriptional regulator
CP966_RS07040	COG1960	acyl-CoA dehydrogenase activity
CP966_RS07050	COG0640	Transcriptional regulator
CP966_RS07055	COG0697	spore germination
CP966_RS07090	COG2851	Citrate transporter
CP966_RS07095	COG0243	molybdopterin cofactor binding
CP966_RS07100	COG1309	transcriptional regulator
CP966_RS07110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP966_RS07115	COG2188	Transcriptional regulator
CP966_RS07155	COG1595	DNA-templated transcription, initiation
CP966_RS07180	COG2755	lipolytic protein G-D-S-L family
CP966_RS07210	COG1725	Transcriptional regulator
CP966_RS07255	COG0662	Cupin 2, conserved barrel domain protein
CP966_RS07255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP966_RS07270	COG0587	DNA-directed DNA polymerase activity
CP966_RS07295	COG1126	abc transporter atp-binding protein
CP966_RS07305	COG0765	amino acid transport
CP966_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP966_RS07320	COG1799	cell septum assembly
CP966_RS07325	COG1960	acyl-CoA dehydrogenase activity
CP966_RS07330	COG0477	Major facilitator Superfamily
CP966_RS07340	COG0671	phosphoesterase, PA-phosphatase related
CP966_RS07350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP966_RS07370	COG1160	GTP binding
CP966_RS07380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP966_RS07400	COG1397	ADP-ribosylglycohydrolase
CP966_RS07410	COG1187	pseudouridine synthase activity
CP966_RS07415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP966_RS07420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP966_RS07435	COG0686	Belongs to the AlaDH PNT family
CP966_RS07445	COG0494	nUDIX hydrolase
CP966_RS07450	COG0504	CTP synthase activity
CP966_RS07455	COG3387	PFAM Glycoside hydrolase 15-related
CP966_RS07475	COG0497	DNA recombination
CP966_RS07480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP966_RS07500	COG1120	ATPase activity
CP966_RS07505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS07510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS07515	COG0647	UMP catabolic process
CP966_RS07555	COG2094	Belongs to the DNA glycosylase MPG family
CP966_RS07565	COG1881	PFAM PEBP family protein
CP966_RS07585	COG1119	ATPase activity
CP966_RS07605	COG2197	response regulator
CP966_RS07620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CP966_RS07630	COG0842	Transport permease protein
CP966_RS07630	COG1131	(ABC) transporter
CP966_RS07630	COG1716	ATPase activity
CP966_RS07645	COG0560	Phosphoserine phosphatase
CP966_RS07645	COG3830	Belongs to the UPF0237 family
CP966_RS07670	COG2186	Transcriptional regulator
CP966_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS07700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP966_RS07720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP966_RS07725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP966_RS07760	COG3387	PFAM Glycoside hydrolase 15-related
CP966_RS07815	COG0488	(ABC) transporter
CP966_RS07835	COG0235	Class ii aldolase
CP966_RS07850	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CP966_RS07855	COG1492	cobalamin metabolic process
CP966_RS07870	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CP966_RS07875	COG1797	cobyrinic acid a,c-diamide synthase activity
CP966_RS07920	COG1309	transcriptional regulator
CP966_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS07950	COG0765	amino acid transport
CP966_RS07960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CP966_RS07965	COG2318	DinB family
CP966_RS07970	COG0456	acetyltransferase
CP966_RS07975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP966_RS07980	COG1917	Cupin 2, conserved barrel domain protein
CP966_RS07985	COG5285	phytanoyl-CoA dioxygenase
CP966_RS08010	COG1414	Transcriptional regulator
CP966_RS08025	COG2252	PERMEase
CP966_RS08030	COG1595	DNA-templated transcription, initiation
CP966_RS08050	COG4733	cellulase activity
CP966_RS08065	COG4677	pectinesterase activity
CP966_RS08070	COG4677	pectinesterase activity
CP966_RS08075	COG3866	Pectate lyase
CP966_RS08080	COG2755	lipolytic protein G-D-S-L family
CP966_RS08090	COG4677	pectinesterase activity
CP966_RS08095	COG3507	Belongs to the glycosyl hydrolase 43 family
CP966_RS08110	COG3866	Pectate lyase
CP966_RS08115	COG0395	ABC-type sugar transport system, permease component
CP966_RS08130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP966_RS08135	COG1802	Transcriptional regulator
CP966_RS08140	COG1234	tRNA 3'-trailer cleavage
CP966_RS08155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP966_RS08160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP966_RS08170	COG1309	transcriptional regulator
CP966_RS08180	COG1802	Transcriptional regulator
CP966_RS08225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP966_RS08235	COG1595	DNA-templated transcription, initiation
CP966_RS08240	COG2171	N-acyltransferase activity
CP966_RS08250	COG2151	metal-sulfur cluster biosynthetic enzyme
CP966_RS08255	COG0822	iron-sulfur transferase activity
CP966_RS08260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP966_RS08265	COG0396	ATPase activity
CP966_RS08275	COG0719	Fe-S assembly protein
CP966_RS08290	COG2746	aminoglycoside 3-N-acetyltransferase activity
CP966_RS08295	COG1131	(ABC) transporter
CP966_RS08305	COG1612	heme a metabolic process
CP966_RS08325	COG0109	protoheme IX farnesyltransferase activity
CP966_RS08340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP966_RS08355	COG0363	glucosamine-6-phosphate deaminase activity
CP966_RS08360	COG0395	ABC-type sugar transport system, permease component
CP966_RS08365	COG1175	transmembrane transport
CP966_RS08370	COG1653	transport
CP966_RS08375	COG0366	Alpha amylase catalytic
CP966_RS08380	COG1653	transport
CP966_RS08390	COG1695	Transcriptional regulator
CP966_RS08395	COG1136	(ABC) transporter
CP966_RS08405	COG0166	Belongs to the GPI family
CP966_RS08415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP966_RS08420	COG0149	triose-phosphate isomerase activity
CP966_RS08425	COG0126	phosphoglycerate kinase activity
CP966_RS08430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP966_RS08440	COG1481	regulation of sporulation
CP966_RS08445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP966_RS08450	COG1660	Displays ATPase and GTPase activities
CP966_RS08455	COG0322	excinuclease ABC activity
CP966_RS08465	COG0723	plastoquinol--plastocyanin reductase activity
CP966_RS08475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP966_RS08485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP966_RS08510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP966_RS08515	COG0765	amino acid transport
CP966_RS08525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP966_RS08530	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP966_RS08540	COG0387	Pfam Sodium calcium exchanger
CP966_RS08560	COG0556	nucleotide-excision repair
CP966_RS08570	COG0584	glycerophosphoryl diester phosphodiesterase
CP966_RS08575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP966_RS08580	COG0346	lactoylglutathione lyase activity
CP966_RS08585	COG2313	pseudouridylate synthase activity
CP966_RS08590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CP966_RS08590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CP966_RS08595	COG2226	methyltransferase
CP966_RS08600	COG0598	Magnesium transport protein CorA
CP966_RS08635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP966_RS08640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP966_RS08700	COG1953	Uracil, thiamine, allantoin
CP966_RS08705	COG1802	Transcriptional regulator
CP966_RS08720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP966_RS08735	COG0237	dephospho-CoA kinase activity
CP966_RS08750	COG1073	alpha beta
CP966_RS08750	COG2226	methyltransferase
CP966_RS08755	COG1643	Atp-dependent helicase
CP966_RS08795	COG2050	protein possibly involved in aromatic compounds catabolism
CP966_RS08825	COG0411	ABC transporter
CP966_RS08855	COG0737	Belongs to the 5'-nucleotidase family
CP966_RS08880	COG0287	Prephenate dehydrogenase
CP966_RS08880	COG1605	Chorismate mutase
CP966_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS08900	COG1024	Enoyl-CoA hydratase
CP966_RS08930	COG0183	Belongs to the thiolase family
CP966_RS08935	COG1309	transcriptional regulator
CP966_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS08945	COG1960	acyl-CoA dehydrogenase activity
CP966_RS08955	COG2304	oxidoreductase activity
CP966_RS08965	COG0067	glutamate synthase
CP966_RS08965	COG0070	glutamate synthase
CP966_RS08965	COG0069	glutamate synthase activity
CP966_RS08995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP966_RS09000	COG2301	Belongs to the HpcH HpaI aldolase family
CP966_RS09005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP966_RS09015	COG0159	tryptophan synthase activity
CP966_RS09020	COG0133	tryptophan synthase activity
CP966_RS09030	COG0134	indole-3-glycerol-phosphate synthase activity
CP966_RS09055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP966_RS09070	COG0107	imidazoleglycerol-phosphate synthase activity
CP966_RS09075	COG0251	oxidation-reduction process
CP966_RS09080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP966_RS09085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP966_RS09090	COG0131	Imidazoleglycerol-phosphate dehydratase
CP966_RS09095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP966_RS09100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP966_RS09115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP966_RS09120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CP966_RS09140	COG1432	Conserved Protein
CP966_RS09145	COG0587	DNA-directed DNA polymerase activity
CP966_RS09195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP966_RS09210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP966_RS09215	COG3599	regulation of cell shape
CP966_RS09225	COG1799	cell septum assembly
CP966_RS09235	COG1496	oxidoreductase activity
CP966_RS09240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CP966_RS09245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP966_RS09250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP966_RS09260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP966_RS09265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP966_RS09275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP966_RS09290	COG0275	rRNA processing
CP966_RS09300	COG0714	Associated with various cellular activities
CP966_RS09320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP966_RS09330	COG1121	(ABC) transporter
CP966_RS09340	COG1309	transcriptional regulator
CP966_RS09360	COG0352	thiamine-phosphate diphosphorylase activity
CP966_RS09380	COG2022	thiamine diphosphate biosynthetic process
CP966_RS09380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP966_RS09390	COG2022	thiamine diphosphate biosynthetic process
CP966_RS09395	COG2815	serine threonine protein kinase
CP966_RS09395	COG0515	serine threonine protein kinase
CP966_RS09400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CP966_RS09405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP966_RS09410	COG2193	ferroxidase activity
CP966_RS09415	COG0243	molybdopterin cofactor binding
CP966_RS09420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP966_RS09435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP966_RS09440	COG0205	6-phosphofructokinase activity
CP966_RS09475	COG1940	carbohydrate kinase activity
CP966_RS09485	COG0003	Pfam Anion-transporting ATPase
CP966_RS09500	COG1022	Amp-dependent synthetase and ligase
CP966_RS09510	COG0438	transferase activity, transferring glycosyl groups
CP966_RS09520	COG0534	Mate efflux family protein
CP966_RS09565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP966_RS09570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP966_RS09575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP966_RS09580	COG0723	plastoquinol--plastocyanin reductase activity
CP966_RS09585	COG2010	Cytochrome c
CP966_RS09590	COG1845	cytochrome c oxidase, subunit III
CP966_RS09600	COG1376	ErfK ybiS ycfS ynhG family protein
CP966_RS09610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP966_RS09615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP966_RS09625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP966_RS09650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CP966_RS09655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP966_RS09655	COG0515	serine threonine protein kinase
CP966_RS09660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP966_RS09665	COG2197	response regulator
CP966_RS09670	COG4585	Histidine kinase
CP966_RS09690	COG2226	methyltransferase
CP966_RS09695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP966_RS09725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CP966_RS09735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP966_RS09740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP966_RS09745	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP966_RS09755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP966_RS09805	COG0321	lipoyl(octanoyl) transferase activity
CP966_RS09810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP966_RS09830	COG0174	glutamine synthetase
CP966_RS09835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CP966_RS09890	COG2188	Transcriptional regulator
CP966_RS09895	COG0456	acetyltransferase
CP966_RS09950	COG0745	RESPONSE REGULATOR receiver
CP966_RS09965	COG2197	response regulator
CP966_RS09995	COG1309	transcriptional regulator
CP966_RS10025	COG0366	Alpha amylase catalytic
CP966_RS10030	COG3833	ABC-type maltose transport systems, permease component
CP966_RS10035	COG1175	transmembrane transport
CP966_RS10040	COG2182	Extracellular solute-binding protein
CP966_RS10045	COG1609	Transcriptional regulator
CP966_RS10055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP966_RS10075	COG0174	glutamine synthetase
CP966_RS10090	COG1959	2 iron, 2 sulfur cluster binding
CP966_RS10115	COG2814	Major facilitator Superfamily
CP966_RS10130	COG0477	Major facilitator Superfamily
CP966_RS10135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP966_RS10155	COG1994	Peptidase M50
CP966_RS10195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS10200	COG1120	ATPase activity
CP966_RS10210	COG2837	iron assimilation
CP966_RS10215	COG0672	)-iron permease
CP966_RS10230	COG1309	transcriptional regulator
CP966_RS10240	COG2814	Major facilitator Superfamily
CP966_RS10245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP966_RS10265	COG2259	Doxx family
CP966_RS10315	COG0789	Transcriptional regulator
CP966_RS10325	COG0557	exoribonuclease II activity
CP966_RS10330	COG3022	response to hydroperoxide
CP966_RS10335	COG0800	Aldolase
CP966_RS10350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP966_RS10370	COG2030	dehydratase
CP966_RS10375	COG4585	Histidine kinase
CP966_RS10380	COG2197	response regulator
CP966_RS10395	COG0477	Major facilitator Superfamily
CP966_RS10405	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP966_RS10415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS10450	COG0438	transferase activity, transferring glycosyl groups
CP966_RS10455	COG1309	transcriptional regulator
CP966_RS10495	COG3845	ABC transporter
CP966_RS10510	COG2124	cytochrome p450
CP966_RS10515	COG0183	Belongs to the thiolase family
CP966_RS10540	COG4122	O-methyltransferase activity
CP966_RS10670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP966_RS10685	COG1358	cellular component organization or biogenesis
CP966_RS10730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP966_RS10735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP966_RS10745	COG0477	Major facilitator Superfamily
CP966_RS10750	COG1309	transcriptional regulator
CP966_RS10765	COG0667	Aldo Keto reductase
CP966_RS10770	COG0789	Transcriptional regulator
CP966_RS10800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP966_RS10805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP966_RS10810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP966_RS10855	COG2130	NADP-dependent
CP966_RS10865	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP966_RS10870	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP966_RS10880	COG1879	ABC-type sugar transport system periplasmic component
CP966_RS10885	COG1609	Transcriptional regulator
CP966_RS10920	COG1129	ABC transporter
CP966_RS10925	COG4214	carbohydrate transport
CP966_RS10930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP966_RS10935	COG3940	Belongs to the glycosyl hydrolase 43 family
CP966_RS10940	COG3507	Belongs to the glycosyl hydrolase 43 family
CP966_RS10955	COG1733	regulation of RNA biosynthetic process
CP966_RS10995	COG3507	Belongs to the glycosyl hydrolase 43 family
CP966_RS11000	COG0395	ABC-type sugar transport system, permease component
CP966_RS11005	COG1175	transmembrane transport
CP966_RS11070	COG1414	Transcriptional regulator
CP966_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS11095	COG0825	malonyl-CoA metabolic process
CP966_RS11095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP966_RS11120	COG1077	Cell shape determining protein MreB Mrl
CP966_RS11135	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS11155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP966_RS11230	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS11245	COG3842	ATPase activity
CP966_RS11255	COG2409	Drug exporters of the RND superfamily
CP966_RS11300	COG1070	Carbohydrate kinase
CP966_RS11320	COG0358	DNA primase activity
CP966_RS11330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP966_RS11340	COG2949	membrane
CP966_RS11350	COG0243	molybdopterin cofactor binding
CP966_RS11370	COG1733	regulation of RNA biosynthetic process
CP966_RS11395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP966_RS11395	COG2146	nitrite reductase [NAD(P)H] activity
CP966_RS11430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP966_RS11430	COG0574	Belongs to the PEP-utilizing enzyme family
CP966_RS11470	COG3629	intracellular signal transduction
CP966_RS11470	COG3903	Transcriptional regulator
CP966_RS11475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP966_RS11505	COG0423	glycine-tRNA ligase activity
CP966_RS11515	COG1121	(ABC) transporter
CP966_RS11520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP966_RS11530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP966_RS11535	COG1381	Involved in DNA repair and RecF pathway recombination
CP966_RS11575	COG0456	acetyltransferase
CP966_RS11575	COG1214	PFAM Peptidase M22, glycoprotease
CP966_RS11585	COG2197	response regulator
CP966_RS11590	COG4585	Histidine kinase
CP966_RS11595	COG2409	Drug exporters of the RND superfamily
CP966_RS11605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP966_RS11625	COG2723	6-phospho-beta-galactosidase activity
CP966_RS11630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP966_RS11665	COG2315	Protein conserved in bacteria
CP966_RS11675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP966_RS11685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP966_RS11690	COG4948	Mandelate Racemase Muconate Lactonizing
CP966_RS11700	COG3250	beta-galactosidase activity
CP966_RS11700	COG5297	Belongs to the glycosyl hydrolase family 6
CP966_RS11725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP966_RS11730	COG1234	tRNA 3'-trailer cleavage
CP966_RS11735	COG0537	adenosine 5'-monophosphoramidase activity
CP966_RS11740	COG0793	Belongs to the peptidase S41A family
CP966_RS11740	COG4946	Tricorn protease homolog
CP966_RS11765	COG0484	heat shock protein binding
CP966_RS11770	COG1420	regulation of RNA biosynthetic process
CP966_RS11800	COG0481	GTPase activity
CP966_RS11805	COG0268	Binds directly to 16S ribosomal RNA
CP966_RS11830	COG1555	photosystem II stabilization
CP966_RS11830	COG1596	polysaccharide export
CP966_RS11835	COG1307	EDD domain protein, DegV family
CP966_RS11845	COG0495	leucyl-tRNA aminoacylation
CP966_RS11860	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP966_RS11880	COG0477	Major facilitator Superfamily
CP966_RS11895	COG0588	phosphoglycerate mutase activity
CP966_RS11900	COG0799	negative regulation of ribosome biogenesis
CP966_RS11910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP966_RS11915	COG0501	Belongs to the peptidase M48B family
CP966_RS11930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP966_RS11940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP966_RS11950	COG1215	transferase activity, transferring glycosyl groups
CP966_RS11965	COG3540	Alkaline phosphatase
CP966_RS11970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP966_RS11975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP966_RS11980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP966_RS12035	COG0673	inositol 2-dehydrogenase activity
CP966_RS12040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP966_RS12045	COG1530	ribonuclease E activity
CP966_RS12060	COG0463	Glycosyl transferase, family 2
CP966_RS12060	COG0457	Tetratricopeptide repeat
CP966_RS12080	COG0772	Belongs to the SEDS family
CP966_RS12085	COG0768	penicillin binding
CP966_RS12100	COG1077	Cell shape determining protein MreB Mrl
CP966_RS12105	COG0105	UTP biosynthetic process
CP966_RS12115	COG0285	dihydrofolate synthase activity
CP966_RS12120	COG0525	valine-tRNA ligase activity
CP966_RS12130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP966_RS12135	COG0740	serine-type endopeptidase activity
CP966_RS12140	COG0740	serine-type endopeptidase activity
CP966_RS12145	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP966_RS12265	COG3594	Acyltransferase
CP966_RS12280	COG4552	Acetyltransferase involved in intracellular survival and related
CP966_RS12290	COG0698	ribose 5-phosphate isomerase
CP966_RS12295	COG1113	amino acid transport
CP966_RS12300	COG0515	serine threonine protein kinase
CP966_RS12310	COG1268	BioY protein
CP966_RS12315	COG1940	carbohydrate kinase activity
CP966_RS12325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP966_RS12330	COG1116	anion transmembrane transporter activity
CP966_RS12345	COG1113	amino acid transport
CP966_RS12350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CP966_RS12355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP966_RS12425	COG0697	spore germination
CP966_RS12430	COG1846	Transcriptional regulator
CP966_RS12435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP966_RS12460	COG1595	DNA-templated transcription, initiation
CP966_RS12470	COG1131	(ABC) transporter
CP966_RS12490	COG0668	transmembrane transport
CP966_RS12505	COG1653	transport
CP966_RS12510	COG1175	transmembrane transport
CP966_RS12515	COG0395	ABC-type sugar transport system, permease component
CP966_RS12520	COG1486	melibiose metabolic process
CP966_RS12535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP966_RS12565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP966_RS12600	COG0629	single-stranded DNA binding
CP966_RS12630	COG0477	Major facilitator Superfamily
CP966_RS12705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP966_RS12720	COG1120	ATPase activity
CP966_RS12725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS12730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS12735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP966_RS12815	COG0438	transferase activity, transferring glycosyl groups
CP966_RS12820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP966_RS12840	COG0438	transferase activity, transferring glycosyl groups
CP966_RS12865	COG0492	ferredoxin-NADP+ reductase activity
CP966_RS12925	COG3962	Belongs to the TPP enzyme family
CP966_RS12930	COG3718	enzyme involved in inositol metabolism
CP966_RS12940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP966_RS12955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP966_RS12965	COG2409	Drug exporters of the RND superfamily
CP966_RS12990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP966_RS13005	COG1129	ABC transporter
CP966_RS13015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP966_RS13020	COG1869	D-ribose catabolic process
CP966_RS13040	COG0673	inositol 2-dehydrogenase activity
CP966_RS13045	COG1609	Transcriptional regulator
CP966_RS13075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP966_RS13085	COG1595	DNA-templated transcription, initiation
CP966_RS13095	COG1472	Belongs to the glycosyl hydrolase 3 family
CP966_RS13140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CP966_RS13145	COG2356	endonuclease I
CP966_RS13155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CP966_RS13185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP966_RS13215	COG1946	Acyl-CoA thioesterase
CP966_RS13230	COG1309	transcriptional regulator
CP966_RS13235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP966_RS13250	COG1960	acyl-CoA dehydrogenase activity
CP966_RS13280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP966_RS13310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP966_RS13320	COG0589	response to stress
CP966_RS13330	COG4977	sequence-specific DNA binding
CP966_RS13335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CP966_RS13365	COG0395	ABC-type sugar transport system, permease component
CP966_RS13375	COG3979	chitinase
CP966_RS13385	COG0745	RESPONSE REGULATOR receiver
CP966_RS13395	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP966_RS13410	COG0406	alpha-ribazole phosphatase activity
CP966_RS13465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS13500	COG0765	amino acid transport
CP966_RS13505	COG0765	amino acid transport
CP966_RS13510	COG1126	abc transporter atp-binding protein
CP966_RS13525	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS13530	COG3397	chitin binding
CP966_RS13575	COG0673	inositol 2-dehydrogenase activity
CP966_RS13580	COG4702	Belongs to the UPF0303 family
CP966_RS13590	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP966_RS13605	COG3764	Sortase (surface protein transpeptidase)
CP966_RS13660	COG1074	ATP-dependent DNA helicase activity
CP966_RS13715	COG2267	carboxylic ester hydrolase activity
CP966_RS13755	COG2733	membrane
CP966_RS13770	COG1131	(ABC) transporter
CP966_RS13785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP966_RS13790	COG2076	Multidrug Resistance protein
CP966_RS13815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP966_RS13825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP966_RS13830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP966_RS13835	COG1263	PTS System
CP966_RS13840	COG1263	PTS System
CP966_RS13880	COG1113	amino acid transport
CP966_RS13890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP966_RS13900	COG1335	isochorismatase
CP966_RS13940	COG0277	FAD linked oxidase domain protein
CP966_RS13950	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP966_RS13960	COG1174	glycine betaine transport
CP966_RS13970	COG1174	glycine betaine transport
CP966_RS13980	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP966_RS14035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP966_RS14045	COG1678	Uncharacterized ACR, COG1678
CP966_RS14050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP966_RS14055	COG0776	regulation of translation
CP966_RS14065	COG3973	AAA domain
CP966_RS14090	COG2223	nitrite transmembrane transporter activity
CP966_RS14115	COG0583	DNA-binding transcription factor activity
CP966_RS14125	COG1501	Belongs to the glycosyl hydrolase 31 family
CP966_RS14130	COG1609	Transcriptional regulator
CP966_RS14140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP966_RS14145	COG0793	Belongs to the peptidase S41A family
CP966_RS14155	COG2884	Cell division ATP-binding protein ftsE
CP966_RS14170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP966_RS14175	COG0515	serine threonine protein kinase
CP966_RS14180	COG0515	serine threonine protein kinase
CP966_RS14195	COG1175	transmembrane transport
CP966_RS14200	COG0395	ABC-type sugar transport system, permease component
CP966_RS14205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP966_RS14210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP966_RS14215	COG1216	Glycosyl transferase, family 2
CP966_RS14230	COG1764	response to oxidative stress
CP966_RS14235	COG1846	Transcriptional regulator
CP966_RS14245	COG2197	response regulator
CP966_RS14250	COG1309	transcriptional regulator
CP966_RS14260	COG1134	teichoic acid transport
CP966_RS14265	COG2902	Dehydrogenase
CP966_RS14290	COG0653	protein targeting
CP966_RS14300	COG3214	Protein conserved in bacteria
CP966_RS14305	COG2197	response regulator
CP966_RS14310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP966_RS14320	COG0823	Involved in the tonB-independent uptake of proteins
CP966_RS14330	COG0745	RESPONSE REGULATOR receiver
CP966_RS14355	COG0714	Associated with various cellular activities
CP966_RS14400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP966_RS14410	COG1482	cell wall glycoprotein biosynthetic process
CP966_RS14420	COG2835	tetraacyldisaccharide 4'-kinase activity
CP966_RS14425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP966_RS14465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP966_RS14470	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CP966_RS14470	COG0778	Nitroreductase
CP966_RS14495	COG1316	TRANSCRIPTIONal
CP966_RS14500	COG1316	TRANSCRIPTIONal
CP966_RS14510	COG0463	Glycosyl transferase, family 2
CP966_RS14525	COG1316	TRANSCRIPTIONal
CP966_RS14540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP966_RS14560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CP966_RS14575	COG2205	protein histidine kinase activity
CP966_RS14580	COG0745	RESPONSE REGULATOR receiver
CP966_RS14585	COG3104	oligopeptide transport
CP966_RS14615	COG1366	Belongs to the anti-sigma-factor antagonist family
CP966_RS14620	COG1191	sigma factor activity
CP966_RS14635	COG1228	amidohydrolase
CP966_RS14645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP966_RS14650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CP966_RS14685	COG2986	histidine ammonia-lyase
CP966_RS14695	COG1174	glycine betaine transport
CP966_RS14700	COG1174	glycine betaine transport
CP966_RS14715	COG4221	oxidoreductase activity
CP966_RS14730	COG2755	lipolytic protein G-D-S-L family
CP966_RS14735	COG0183	Belongs to the thiolase family
CP966_RS14775	COG1136	(ABC) transporter
CP966_RS14780	COG0577	efflux transmembrane transporter activity
CP966_RS14785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP966_RS14790	COG1252	NADH dehydrogenase
CP966_RS14810	COG0148	phosphopyruvate hydratase activity
CP966_RS14825	COG2124	cytochrome p450
CP966_RS14875	COG0577	efflux transmembrane transporter activity
CP966_RS14880	COG1136	(ABC) transporter
CP966_RS14885	COG0477	Major facilitator Superfamily
CP966_RS14895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP966_RS14925	COG4585	Histidine kinase
CP966_RS14935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP966_RS14940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP966_RS14945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP966_RS14950	COG0193	aminoacyl-tRNA hydrolase activity
CP966_RS14960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CP966_RS14970	COG1309	transcriptional regulator
CP966_RS14985	COG4106	trans-aconitate 2-methyltransferase activity
CP966_RS14995	COG2197	response regulator
CP966_RS15005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP966_RS15060	COG0488	(ABC) transporter
CP966_RS15065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP966_RS15070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP966_RS15080	COG0084	hydrolase, TatD family'
CP966_RS15100	COG0768	penicillin binding
CP966_RS15115	COG0310	cobalt ion transport
CP966_RS15125	COG1122	ATPase activity
CP966_RS15130	COG1846	Transcriptional regulator
CP966_RS15135	COG1764	response to oxidative stress
CP966_RS15160	COG2409	Drug exporters of the RND superfamily
CP966_RS15170	COG0793	Belongs to the peptidase S41A family
CP966_RS15170	COG4946	Tricorn protease homolog
CP966_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS15185	COG2267	carboxylic ester hydrolase activity
CP966_RS15190	COG2072	flavoprotein involved in K transport
CP966_RS15250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP966_RS15255	COG4106	trans-aconitate 2-methyltransferase activity
CP966_RS15270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP966_RS15275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP966_RS15285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP966_RS15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP966_RS15295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP966_RS15345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP966_RS15350	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP966_RS15350	COG0315	cyclic pyranopterin monophosphate synthase activity
CP966_RS15355	COG0315	cyclic pyranopterin monophosphate synthase activity
CP966_RS15365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP966_RS15370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP966_RS15385	COG0477	Major facilitator Superfamily
CP966_RS15395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP966_RS15405	COG1970	mechanosensitive ion channel activity
CP966_RS15420	COG3191	aminopeptidase activity
CP966_RS15440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP966_RS15440	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CP966_RS15440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CP966_RS15450	COG1349	DNA-binding transcription factor activity
CP966_RS15455	COG0477	Major facilitator Superfamily
CP966_RS15475	COG1247	-acetyltransferase
CP966_RS15480	COG3384	dioxygenase
CP966_RS15485	COG1846	Transcriptional regulator
CP966_RS15505	COG1414	Transcriptional regulator
CP966_RS15545	COG2018	Roadblock/LC7 domain
CP966_RS15565	COG1733	regulation of RNA biosynthetic process
CP966_RS15585	COG0386	Belongs to the glutathione peroxidase family
CP966_RS15610	COG1686	Belongs to the peptidase S11 family
CP966_RS15645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP966_RS15685	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS15690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP966_RS15700	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS15715	COG2197	response regulator
CP966_RS15730	COG3629	intracellular signal transduction
CP966_RS15730	COG3903	Transcriptional regulator
CP966_RS15760	COG1024	Enoyl-CoA hydratase
CP966_RS15765	COG0515	serine threonine protein kinase
CP966_RS15765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP966_RS15775	COG1309	transcriptional regulator
CP966_RS15780	COG1522	sequence-specific DNA binding
CP966_RS15785	COG1280	lysine exporter protein (LysE YggA)
CP966_RS15795	COG1960	acyl-CoA dehydrogenase activity
CP966_RS15875	COG2072	flavoprotein involved in K transport
CP966_RS15880	COG1231	oxidoreductase activity
CP966_RS15890	COG1024	Enoyl-CoA hydratase
CP966_RS15940	COG1960	acyl-CoA dehydrogenase activity
CP966_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS15970	COG1960	acyl-CoA dehydrogenase activity
CP966_RS15975	COG1960	acyl-CoA dehydrogenase activity
CP966_RS16000	COG1366	Belongs to the anti-sigma-factor antagonist family
CP966_RS16045	COG1131	(ABC) transporter
CP966_RS16060	COG2945	thiolester hydrolase activity
CP966_RS16060	COG0596	Alpha beta hydrolase
CP966_RS16070	COG4821	SIS domain
CP966_RS16100	COG0259	pyridoxamine-phosphate oxidase activity
CP966_RS16115	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS16130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP966_RS16145	COG5006	permease, DMT superfamily
CP966_RS16155	COG0277	FAD linked oxidase domain protein
CP966_RS16160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP966_RS16175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CP966_RS16195	COG0667	Aldo Keto reductase
CP966_RS16220	COG2252	PERMEase
CP966_RS16230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP966_RS16255	COG2814	Major facilitator Superfamily
CP966_RS16265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP966_RS16270	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP966_RS16275	COG1278	Cold shock
CP966_RS16300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP966_RS16315	COG1061	Type III restriction enzyme res subunit
CP966_RS16330	COG3973	AAA domain
CP966_RS16335	COG3142	Participates in the control of copper homeostasis
CP966_RS16360	COG1737	Transcriptional regulator
CP966_RS16365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CP966_RS16370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP966_RS16370	COG1263	PTS System
CP966_RS16380	COG0477	Major facilitator Superfamily
CP966_RS16395	COG0459	protein refolding
CP966_RS16415	COG0463	Glycosyl transferase, family 2
CP966_RS16460	COG3300	MHYT domain
CP966_RS16460	COG5001	Diguanylate cyclase
CP966_RS16475	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP966_RS16545	COG3321	synthase
CP966_RS16545	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS16545	COG0604	alcohol dehydrogenase
CP966_RS16565	COG3842	ATPase activity
CP966_RS16575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP966_RS16585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP966_RS16590	COG0215	cysteine-tRNA ligase activity
CP966_RS16595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP966_RS16600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP966_RS16605	COG1329	Transcriptional regulator
CP966_RS16625	COG5002	protein histidine kinase activity
CP966_RS16670	COG2188	Transcriptional regulator
CP966_RS16715	COG4974	Belongs to the 'phage' integrase family
CP966_RS16725	COG0588	phosphoglycerate mutase activity
CP966_RS16740	COG1648	precorrin-2 dehydrogenase activity
CP966_RS16740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP966_RS16755	COG0438	transferase activity, transferring glycosyl groups
CP966_RS16765	COG0791	NLP P60 protein
CP966_RS16790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP966_RS16815	COG0604	alcohol dehydrogenase
CP966_RS16815	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS16815	COG3321	synthase
CP966_RS16830	COG2186	Transcriptional regulator
CP966_RS16840	COG2188	Transcriptional regulator
CP966_RS16845	COG4552	Acetyltransferase involved in intracellular survival and related
CP966_RS16855	COG1490	D-aminoacyl-tRNA deacylase activity
CP966_RS16860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP966_RS16870	COG3485	protocatechuate 3,4-dioxygenase
CP966_RS16915	COG2897	thiosulfate sulfurtransferase activity
CP966_RS16940	COG0745	RESPONSE REGULATOR receiver
CP966_RS16945	COG1609	Transcriptional regulator
CP966_RS16950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP966_RS16995	COG0737	Belongs to the 5'-nucleotidase family
CP966_RS17000	COG0456	acetyltransferase
CP966_RS17015	COG1131	(ABC) transporter
CP966_RS17030	COG1725	Transcriptional regulator
CP966_RS17035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CP966_RS17050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CP966_RS17060	COG0494	nUDIX hydrolase
CP966_RS17060	COG0406	alpha-ribazole phosphatase activity
CP966_RS17080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP966_RS17085	COG0306	phosphate transporter
CP966_RS17095	COG1937	Protein conserved in bacteria
CP966_RS17105	COG0277	FAD linked oxidase domain protein
CP966_RS17110	COG0671	phosphoesterase, PA-phosphatase related
CP966_RS17115	COG0741	lytic transglycosylase activity
CP966_RS17115	COG1196	nuclear chromosome segregation
CP966_RS17115	COG0739	heme binding
CP966_RS17205	COG2226	methyltransferase
CP966_RS17215	COG1252	NADH dehydrogenase
CP966_RS17245	COG0579	oxidoreductase
CP966_RS17250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP966_RS17260	COG0667	Aldo Keto reductase
CP966_RS17275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP966_RS17275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP966_RS17285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP966_RS17290	COG0494	nUDIX hydrolase
CP966_RS17300	COG1349	DNA-binding transcription factor activity
CP966_RS17315	COG1136	(ABC) transporter
CP966_RS17360	COG0513	Belongs to the DEAD box helicase family
CP966_RS17395	COG1643	Atp-dependent helicase
CP966_RS17420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP966_RS17430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP966_RS17445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP966_RS17450	COG0047	phosphoribosylformylglycinamidine synthase activity
CP966_RS17455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP966_RS17490	COG2197	response regulator
CP966_RS17500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP966_RS17515	COG0151	Belongs to the GarS family
CP966_RS17540	COG2197	response regulator
CP966_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS17580	COG1132	(ABC) transporter
CP966_RS17580	COG2375	cellular response to nickel ion
CP966_RS17600	COG0433	COG0433 Predicted ATPase
CP966_RS17615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP966_RS17645	COG1191	sigma factor activity
CP966_RS17650	COG1191	sigma factor activity
CP966_RS17680	COG3467	pyridoxamine 5'-phosphate
CP966_RS17685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CP966_RS17695	COG2205	protein histidine kinase activity
CP966_RS17700	COG0745	RESPONSE REGULATOR receiver
CP966_RS17715	COG1846	Transcriptional regulator
CP966_RS17765	COG0784	Response regulator, receiver
CP966_RS17770	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS17775	COG1595	DNA-templated transcription, initiation
CP966_RS17810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP966_RS17825	COG0653	protein targeting
CP966_RS17845	COG0006	proline dipeptidase activity
CP966_RS17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP966_RS17885	COG1999	signal sequence binding
CP966_RS17900	COG2837	iron assimilation
CP966_RS17905	COG0077	Prephenate dehydratase
CP966_RS17910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP966_RS17915	COG0561	phosphatase activity
CP966_RS17945	COG1131	(ABC) transporter
CP966_RS17960	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CP966_RS17970	COG0561	phosphatase activity
CP966_RS17980	COG4988	ABC transporter
CP966_RS17985	COG1294	oxidase, subunit
CP966_RS17990	COG1271	oxidase subunit
CP966_RS17995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP966_RS18000	COG1609	Transcriptional regulator
CP966_RS18020	COG1733	regulation of RNA biosynthetic process
CP966_RS18030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP966_RS18055	COG0662	Cupin 2, conserved barrel domain protein
CP966_RS18060	COG1950	PFAM Membrane protein of
CP966_RS18065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP966_RS18070	COG0626	cystathionine gamma-synthase activity
CP966_RS18105	COG2814	Major facilitator Superfamily
CP966_RS18130	COG0305	Participates in initiation and elongation during chromosome replication
CP966_RS18150	COG0534	Mate efflux family protein
CP966_RS18155	COG0359	binds to the 23S rRNA
CP966_RS18160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP966_RS18165	COG0629	single-stranded DNA binding
CP966_RS18170	COG0360	Binds together with S18 to 16S ribosomal RNA
CP966_RS18195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP966_RS18220	COG0617	tRNA 3'-terminal CCA addition
CP966_RS18235	COG0515	serine threonine protein kinase
CP966_RS18235	COG2815	serine threonine protein kinase
CP966_RS18240	COG1595	DNA-templated transcription, initiation
CP966_RS18250	COG0492	ferredoxin-NADP+ reductase activity
CP966_RS18255	COG3118	belongs to the thioredoxin family
CP966_RS18270	COG1192	Involved in chromosome partitioning
CP966_RS18275	COG0357	Ribosomal RNA small subunit methyltransferase G
CP966_RS18285	COG0706	membrane insertase activity
CP966_RS18290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP966_RS18295	COG0594	ribonuclease P activity
CP966_RS18300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CP966_RS18305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CP966_RS18315	COG0592	DNA-directed DNA polymerase activity
CP966_RS18320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP966_RS18325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP966_RS18330	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CP966_RS18335	COG0187	DNA topoisomerase II activity
CP966_RS18340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP966_RS18370	COG0515	serine threonine protein kinase
CP966_RS18395	COG0705	Rhomboid family
CP966_RS18395	COG0457	Tetratricopeptide repeat
CP966_RS18410	COG3764	Sortase (surface protein transpeptidase)
CP966_RS18425	COG3764	Sortase (surface protein transpeptidase)
CP966_RS18430	COG3764	Sortase (surface protein transpeptidase)
CP966_RS18435	COG0515	serine threonine protein kinase
CP966_RS18445	COG0768	penicillin binding
CP966_RS18460	COG1716	ATPase activity
CP966_RS18465	COG1716	ATPase activity
CP966_RS18495	COG1960	acyl-CoA dehydrogenase activity
CP966_RS18500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP966_RS18505	COG2151	metal-sulfur cluster biosynthetic enzyme
CP966_RS18510	COG3396	Phenylacetate-CoA oxygenase
CP966_RS18515	COG3460	Phenylacetate-CoA oxygenase
CP966_RS18520	COG3396	Phenylacetate-CoA oxygenase
CP966_RS18545	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP966_RS18550	COG1309	transcriptional regulator
CP966_RS18555	COG1522	sequence-specific DNA binding
CP966_RS18585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP966_RS18605	COG0604	alcohol dehydrogenase
CP966_RS18605	COG3321	synthase
CP966_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS18620	COG0515	serine threonine protein kinase
CP966_RS18625	COG0515	serine threonine protein kinase
CP966_RS18630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CP966_RS18640	COG0022	dehydrogenase e1 component
CP966_RS18645	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP966_RS18725	COG1362	aminopeptidase activity
CP966_RS18730	COG1960	acyl-CoA dehydrogenase activity
CP966_RS18745	COG1741	Belongs to the pirin family
CP966_RS18765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP966_RS18775	COG3866	Pectate lyase
CP966_RS18810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP966_RS18825	COG1289	transmembrane transporter activity
CP966_RS18845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP966_RS18880	COG4249	Peptidase C14 caspase catalytic subunit p20
CP966_RS18880	COG2319	Wd-40 repeat
CP966_RS18905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP966_RS18910	COG1957	nucleoside hydrolase
CP966_RS18920	COG0366	Alpha amylase catalytic
CP966_RS18970	COG0667	Aldo Keto reductase
CP966_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS18995	COG4977	sequence-specific DNA binding
CP966_RS19065	COG1316	TRANSCRIPTIONal
CP966_RS19155	COG0464	growth
CP966_RS19250	COG0513	Belongs to the DEAD box helicase family
CP966_RS19255	COG1278	Cold shock
CP966_RS19260	COG2409	Drug exporters of the RND superfamily
CP966_RS19265	COG4585	Histidine kinase
CP966_RS19310	COG1595	DNA-templated transcription, initiation
CP966_RS19315	COG1252	NADH dehydrogenase
CP966_RS19320	COG2508	Transcriptional regulator
CP966_RS19320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CP966_RS19325	COG0019	diaminopimelate decarboxylase activity
CP966_RS19340	COG2267	carboxylic ester hydrolase activity
CP966_RS19370	COG2188	Transcriptional regulator
CP966_RS19380	COG2188	Transcriptional regulator
CP966_RS19445	COG0717	Belongs to the dCTP deaminase family
CP966_RS19450	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CP966_RS19470	COG2181	nitrate reductase activity
CP966_RS19470	COG0247	lactate metabolic process
CP966_RS19475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP966_RS19480	COG0443	Heat shock 70 kDa protein
CP966_RS19485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP966_RS19490	COG0484	heat shock protein binding
CP966_RS19495	COG0789	Transcriptional regulator
CP966_RS19500	COG4213	ABC transporter substrate-binding protein
CP966_RS19510	COG1305	Transglutaminase-like
CP966_RS19555	COG0542	response to heat
CP966_RS19595	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP966_RS19610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP966_RS19615	COG0191	fructose-bisphosphate aldolase activity
CP966_RS19620	COG0477	Major facilitator Superfamily
CP966_RS19630	COG3483	tryptophan 2,3-dioxygenase activity
CP966_RS19635	COG3844	kynureninase activity
CP966_RS19660	COG4585	Histidine kinase
CP966_RS19665	COG2197	response regulator
CP966_RS19670	COG4585	Histidine kinase
CP966_RS19675	COG2197	response regulator
CP966_RS19685	COG2124	cytochrome p450
CP966_RS19690	COG3559	Exporter of polyketide antibiotics
CP966_RS19695	COG1131	(ABC) transporter
CP966_RS19710	COG4303	Ethanolamine ammonia lyase large subunit
CP966_RS19725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP966_RS19740	COG0463	Glycosyl transferase, family 2
CP966_RS19745	COG1802	Transcriptional regulator
CP966_RS19750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP966_RS19755	COG0693	protein deglycase activity
CP966_RS19775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP966_RS19780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP966_RS19800	COG2205	protein histidine kinase activity
CP966_RS19820	COG1595	DNA-templated transcription, initiation
CP966_RS19845	COG0701	Predicted permease
CP966_RS19920	COG1408	metallophosphoesterase
CP966_RS19930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP966_RS19945	COG0003	Pfam Anion-transporting ATPase
CP966_RS19960	COG0251	oxidation-reduction process
CP966_RS19970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP966_RS20005	COG2267	carboxylic ester hydrolase activity
CP966_RS20015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP966_RS20020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP966_RS20025	COG0288	reversible hydration of carbon dioxide
CP966_RS20105	COG1205	dead DEAH box helicase
CP966_RS20105	COG1111	helicase
CP966_RS20110	COG1366	Belongs to the anti-sigma-factor antagonist family
CP966_RS20120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP966_RS20140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP966_RS20140	COG1754	DNA topoisomerase type I activity
CP966_RS20145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP966_RS20150	COG0470	DNA polymerase III
CP966_RS20195	COG1674	ftsk spoiiie
CP966_RS20225	COG2188	Transcriptional regulator
CP966_RS20230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CP966_RS20295	COG2197	response regulator
CP966_RS20305	COG2197	response regulator
CP966_RS20310	COG4585	Histidine kinase
CP966_RS20315	COG1136	(ABC) transporter
CP966_RS20315	COG0577	efflux transmembrane transporter activity
CP966_RS20325	COG3903	Transcriptional regulator
CP966_RS20325	COG3629	intracellular signal transduction
CP966_RS20330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP966_RS20330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP966_RS20355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP966_RS20360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP966_RS20365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP966_RS20370	COG0254	rRNA binding
CP966_RS20380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP966_RS20405	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS20425	COG0076	glutamate decarboxylase activity
CP966_RS20435	COG0789	Transcriptional regulator
CP966_RS20440	COG0393	Putative heavy-metal-binding
CP966_RS20455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP966_RS20460	COG2027	D-alanyl-D-alanine carboxypeptidase
CP966_RS20470	COG0037	tRNA processing
CP966_RS20485	COG0302	gtp cyclohydrolase
CP966_RS20500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CP966_RS20540	COG0649	NAD binding
CP966_RS20555	COG2197	response regulator
CP966_RS20560	COG1660	Displays ATPase and GTPase activities
CP966_RS20570	COG0640	Transcriptional regulator
CP966_RS20585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP966_RS20590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP966_RS20600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP966_RS20620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CP966_RS20650	COG0739	heme binding
CP966_RS20665	COG2205	protein histidine kinase activity
CP966_RS20670	COG0745	RESPONSE REGULATOR receiver
CP966_RS20680	COG1595	DNA-templated transcription, initiation
CP966_RS20685	COG1194	a g-specific adenine glycosylase
CP966_RS20695	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CP966_RS20715	COG0248	Ppx GppA phosphatase
CP966_RS20720	COG1082	Xylose isomerase domain protein TIM barrel
CP966_RS20725	COG1309	transcriptional regulator
CP966_RS20730	COG0129	dihydroxy-acid dehydratase activity
CP966_RS20740	COG4991	sh3 domain protein
CP966_RS20760	COG1129	ABC transporter
CP966_RS20760	COG0842	Transport permease protein
CP966_RS20770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP966_RS20775	COG1335	isochorismatase
CP966_RS20785	COG0180	Tryptophanyl-tRNA synthetase
CP966_RS20810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP966_RS20815	COG0738	Major facilitator superfamily
CP966_RS20820	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP966_RS20875	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CP966_RS20880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP966_RS20885	COG0181	hydroxymethylbilane synthase activity
CP966_RS20890	COG1648	precorrin-2 dehydrogenase activity
CP966_RS20890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP966_RS20900	COG0113	porphobilinogen synthase activity
CP966_RS20915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP966_RS20925	COG0018	arginyl-trna synthetase
CP966_RS20930	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP966_RS20950	COG1690	Belongs to the RtcB family
CP966_RS20970	COG1742	UPF0060 membrane protein
CP966_RS20975	COG1846	Transcriptional regulator
CP966_RS20980	COG0701	Predicted permease
CP966_RS20995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS21010	COG2205	protein histidine kinase activity
CP966_RS21015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP966_RS21035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP966_RS21050	COG2072	flavoprotein involved in K transport
CP966_RS21055	COG0640	Transcriptional regulator
CP966_RS21080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP966_RS21085	COG0406	alpha-ribazole phosphatase activity
CP966_RS21095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP966_RS21100	COG0785	Cytochrome C biogenesis protein
CP966_RS21105	COG1333	cytochrome c biogenesis protein
CP966_RS21110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP966_RS21140	COG0789	Transcriptional regulator
CP966_RS21150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CP966_RS21155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP966_RS21160	COG0163	prenyltransferase activity
CP966_RS21170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP966_RS21175	COG1573	uracil-dna glycosylase
CP966_RS21190	COG1309	transcriptional regulator
CP966_RS21225	COG1595	DNA-templated transcription, initiation
CP966_RS21250	COG1053	succinate dehydrogenase
CP966_RS21270	COG0583	DNA-binding transcription factor activity
CP966_RS21275	COG1278	Cold shock
CP966_RS21280	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP966_RS21295	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP966_RS21325	COG2226	methyltransferase
CP966_RS21345	COG0242	peptide deformylase activity
CP966_RS21350	COG3103	Sh3 type 3 domain protein
CP966_RS21350	COG1388	LysM domain
CP966_RS21350	COG0791	NLP P60 protein
CP966_RS21360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21370	COG0649	NAD binding
CP966_RS21380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP966_RS21385	COG1034	ATP synthesis coupled electron transport
CP966_RS21390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP966_RS21395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21400	COG0839	Belongs to the complex I subunit 6 family
CP966_RS21405	COG0713	ATP synthesis coupled electron transport
CP966_RS21410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP966_RS21420	COG1007	ATP synthesis coupled electron transport
CP966_RS21425	COG0514	ATP-dependent DNA helicase (RecQ)
CP966_RS21440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP966_RS21465	COG0726	polysaccharide deacetylase
CP966_RS21480	COG0561	phosphatase activity
CP966_RS21485	COG5412	phage tail tape measure protein
CP966_RS21485	COG3953	SLT domain
CP966_RS21495	COG0142	geranyltranstransferase activity
CP966_RS21535	COG2234	aminopeptidase activity
CP966_RS21535	COG4935	Belongs to the peptidase S8 family
CP966_RS21555	COG0702	epimerase
CP966_RS21560	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP966_RS21565	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP966_RS21565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP966_RS21585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21595	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP966_RS21605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP966_RS21610	COG0839	Belongs to the complex I subunit 6 family
CP966_RS21615	COG0713	ATP synthesis coupled electron transport
CP966_RS21620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP966_RS21630	COG1007	ATP synthesis coupled electron transport
CP966_RS21635	COG0501	Belongs to the peptidase M48B family
CP966_RS21640	COG3304	Inner membrane component domain
CP966_RS21650	COG2261	transglycosylase associated protein
CP966_RS21655	COG1666	GTP binding
CP966_RS21675	COG0702	epimerase
CP966_RS21680	COG0402	S-adenosylhomocysteine deaminase activity
CP966_RS21695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP966_RS21700	COG2030	dehydratase
CP966_RS21710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP966_RS21745	COG0515	serine threonine protein kinase
CP966_RS21755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CP966_RS21775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP966_RS21780	COG0436	Aminotransferase
CP966_RS21795	COG0250	Participates in transcription elongation, termination and antitermination
CP966_RS21800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP966_RS21805	COG0081	regulation of translation
CP966_RS21820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP966_RS21825	COG0222	ribosome binding
CP966_RS21835	COG0085	RNA polymerase activity
CP966_RS21840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP966_RS21860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP966_RS21865	COG0049	tRNA binding
CP966_RS21870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP966_RS21875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP966_RS21880	COG2755	lipolytic protein G-D-S-L family
CP966_RS21880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP966_RS21915	COG0051	transcription antitermination factor activity, RNA binding
CP966_RS21920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP966_RS21925	COG0088	Forms part of the polypeptide exit tunnel
CP966_RS21930	COG0089	rRNA binding
CP966_RS21935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP966_RS21940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP966_RS21945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP966_RS21950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP966_RS21955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP966_RS21960	COG0255	Belongs to the universal ribosomal protein uL29 family
CP966_RS21965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP966_RS21970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP966_RS21975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP966_RS21980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP966_RS21985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP966_RS21995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP966_RS22000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP966_RS22005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP966_RS22010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP966_RS22015	COG1841	ribosomal large subunit assembly
CP966_RS22020	COG0200	Binds to the 23S rRNA
CP966_RS22025	COG0201	protein transport
CP966_RS22030	COG0563	adenylate kinase activity
CP966_RS22040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP966_RS22045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP966_RS22050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP966_RS22055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP966_RS22060	COG0202	RNA polymerase activity
CP966_RS22065	COG0203	ribosomal protein L17
CP966_RS22070	COG0101	tRNA pseudouridine synthase activity
CP966_RS22085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP966_RS22090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP966_RS22095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP966_RS22105	COG1072	(Pantothenic acid kinase))
CP966_RS22110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP966_RS22125	COG0736	holo-[acyl-carrier-protein] synthase activity
CP966_RS22135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP966_RS22140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP966_RS22145	COG0802	atpase or kinase
CP966_RS22165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP966_RS22180	COG1609	Transcriptional regulator
CP966_RS22190	COG1316	TRANSCRIPTIONal
CP966_RS22200	COG4941	Belongs to the sigma-70 factor family
CP966_RS22210	COG0726	polysaccharide deacetylase
CP966_RS22215	COG0726	polysaccharide deacetylase
CP966_RS22220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP966_RS22225	COG0459	protein refolding
CP966_RS22235	COG4221	oxidoreductase activity
CP966_RS22245	COG0583	DNA-binding transcription factor activity
CP966_RS22260	COG1595	DNA-templated transcription, initiation
CP966_RS22270	COG0516	GMP reductase activity
CP966_RS22280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP966_RS22295	COG2815	serine threonine protein kinase
CP966_RS22295	COG0515	serine threonine protein kinase
CP966_RS22300	COG0515	serine threonine protein kinase
CP966_RS22305	COG0515	serine threonine protein kinase
CP966_RS22310	COG0515	serine threonine protein kinase
CP966_RS22315	COG0515	serine threonine protein kinase
CP966_RS22315	COG2815	serine threonine protein kinase
CP966_RS22320	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS22340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP966_RS22340	COG0519	Catalyzes the synthesis of GMP from XMP
CP966_RS22380	COG2197	response regulator
CP966_RS22410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS22410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS22425	COG0714	Associated with various cellular activities
CP966_RS22435	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP966_RS22450	COG0045	succinate-CoA ligase (ADP-forming) activity
CP966_RS22480	COG0138	bifunctional purine biosynthesis protein purh
CP966_RS22505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP966_RS22525	COG0039	L-malate dehydrogenase activity
CP966_RS22530	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS22540	COG0517	IMP dehydrogenase activity
CP966_RS22540	COG4175	Glycine betaine
CP966_RS22545	COG4176	ABC-type proline glycine betaine transport system permease component
CP966_RS22555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CP966_RS22560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP966_RS22565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP966_RS22570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP966_RS22575	COG0180	Tryptophanyl-tRNA synthetase
CP966_RS22595	COG0671	phosphoesterase, PA-phosphatase related
CP966_RS22605	COG1295	ribonuclease BN
CP966_RS22610	COG1686	Belongs to the peptidase S11 family
CP966_RS22620	COG1408	metallophosphoesterase
CP966_RS22625	COG2205	protein histidine kinase activity
CP966_RS22630	COG0745	RESPONSE REGULATOR receiver
CP966_RS22635	COG2409	Drug exporters of the RND superfamily
CP966_RS22640	COG1309	transcriptional regulator
CP966_RS22680	COG1053	succinate dehydrogenase
CP966_RS22690	COG2009	succinate dehydrogenase
CP966_RS22700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP966_RS22735	COG1595	DNA-templated transcription, initiation
CP966_RS22750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS22750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS22765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CP966_RS22780	COG1216	Glycosyl transferase, family 2
CP966_RS22795	COG2089	acid synthase
CP966_RS22805	COG2226	methyltransferase
CP966_RS22820	COG1473	amidohydrolase
CP966_RS22820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP966_RS22825	COG1744	ABC transporter substrate-binding protein PnrA-like
CP966_RS22830	COG1744	ABC transporter substrate-binding protein PnrA-like
CP966_RS22835	COG3845	ABC transporter
CP966_RS22845	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP966_RS22880	COG2814	Major facilitator Superfamily
CP966_RS22885	COG0583	DNA-binding transcription factor activity
CP966_RS22895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP966_RS22920	COG2205	protein histidine kinase activity
CP966_RS22925	COG0745	RESPONSE REGULATOR receiver
CP966_RS22930	COG1595	DNA-templated transcription, initiation
CP966_RS22945	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS22950	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS22955	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CP966_RS22965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP966_RS22990	COG4770	biotin carboxylase activity
CP966_RS23000	COG0424	maF-like protein
CP966_RS23015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP966_RS23025	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP966_RS23035	COG1024	Enoyl-CoA hydratase
CP966_RS23045	COG2986	histidine ammonia-lyase
CP966_RS23075	COG1136	(ABC) transporter
CP966_RS23090	COG1064	alcohol dehydrogenase
CP966_RS23095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS23100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS23125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP966_RS23145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP966_RS23170	COG2255	four-way junction helicase activity
CP966_RS23175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP966_RS23190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP966_RS23200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP966_RS23210	COG2255	four-way junction helicase activity
CP966_RS23215	COG1331	Highly conserved protein containing a thioredoxin domain
CP966_RS23225	COG3903	Transcriptional regulator
CP966_RS23225	COG3629	intracellular signal transduction
CP966_RS23230	COG0463	Glycosyl transferase, family 2
CP966_RS23255	COG1309	transcriptional regulator
CP966_RS23260	COG0477	Major facilitator Superfamily
CP966_RS23270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CP966_RS23300	COG0436	Aminotransferase
CP966_RS23315	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP966_RS23330	COG1414	Transcriptional regulator
CP966_RS23335	COG0251	oxidation-reduction process
CP966_RS23430	COG2894	cell division
CP966_RS23490	COG1396	sequence-specific DNA binding
CP966_RS23540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP966_RS23545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CP966_RS23580	COG1136	(ABC) transporter
CP966_RS23600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP966_RS23615	COG0114	fumarate hydratase activity
CP966_RS23620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CP966_RS23620	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CP966_RS23645	COG0778	Nitroreductase
CP966_RS23650	COG1722	exodeoxyribonuclease VII activity
CP966_RS23655	COG1570	exodeoxyribonuclease VII activity
CP966_RS23660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP966_RS23675	COG0012	GTP binding
CP966_RS23680	COG2161	toxin-antitoxin pair type II binding
CP966_RS23685	COG4115	mRNA cleavage
CP966_RS23690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP966_RS23750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP966_RS23755	COG1053	succinate dehydrogenase
CP966_RS23775	COG1217	gtp-binding protein TYPA
CP966_RS23780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP966_RS23785	COG4166	transmembrane transport
CP966_RS23790	COG0601	transmembrane transport
CP966_RS23800	COG4608	Belongs to the ABC transporter superfamily
CP966_RS23810	COG0601	transmembrane transport
CP966_RS23815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP966_RS23820	COG0444	Belongs to the ABC transporter superfamily
CP966_RS23825	COG4608	Belongs to the ABC transporter superfamily
CP966_RS23840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP966_RS23885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP966_RS23890	COG1611	Belongs to the LOG family
CP966_RS23895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP966_RS23905	COG0519	Catalyzes the synthesis of GMP from XMP
CP966_RS23910	COG1024	Enoyl-CoA hydratase
CP966_RS23925	COG1595	DNA-templated transcription, initiation
CP966_RS23935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP966_RS23940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP966_RS23975	COG0598	Magnesium transport protein CorA
CP966_RS23985	COG2814	Major facilitator Superfamily
CP966_RS24000	COG2095	MarC family integral membrane protein
CP966_RS24010	COG1432	Conserved Protein
CP966_RS24020	COG0513	Belongs to the DEAD box helicase family
CP966_RS24075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP966_RS24120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP966_RS24155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP966_RS24205	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP966_RS24215	COG1615	UPF0182 protein
CP966_RS24245	COG0483	inositol monophosphate 1-phosphatase activity
CP966_RS24260	COG1162	GTPase activity
CP966_RS24265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP966_RS24275	COG2135	peptidase activity
CP966_RS24285	COG1595	DNA-templated transcription, initiation
CP966_RS24290	COG5662	AntiSigma factor
CP966_RS24295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CP966_RS24295	COG2199	diguanylate cyclase activity
CP966_RS24310	COG0242	peptide deformylase activity
CP966_RS24320	COG2124	cytochrome p450
CP966_RS24355	COG2188	Transcriptional regulator
CP966_RS24360	COG2182	Extracellular solute-binding protein
CP966_RS24365	COG1175	transmembrane transport
CP966_RS24370	COG0395	ABC-type sugar transport system, permease component
CP966_RS24375	COG1472	Belongs to the glycosyl hydrolase 3 family
CP966_RS24380	COG0363	glucosamine-6-phosphate deaminase activity
CP966_RS24385	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS24405	COG1597	lipid kinase activity
CP966_RS24435	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CP966_RS24440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP966_RS24445	COG0142	geranyltranstransferase activity
CP966_RS24495	COG4106	trans-aconitate 2-methyltransferase activity
CP966_RS24500	COG1126	abc transporter atp-binding protein
CP966_RS24520	COG0281	malic enzyme
CP966_RS24525	COG0604	alcohol dehydrogenase
CP966_RS24555	COG0567	Dehydrogenase, E1 component
CP966_RS24555	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP966_RS24560	COG2205	protein histidine kinase activity
CP966_RS24565	COG0745	RESPONSE REGULATOR receiver
CP966_RS24585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP966_RS24675	COG2205	protein histidine kinase activity
CP966_RS24695	COG3285	dna ligase
CP966_RS24695	COG1793	dna ligase
CP966_RS24700	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP966_RS24730	COG1609	Transcriptional regulator
CP966_RS24860	COG0018	arginyl-trna synthetase
CP966_RS24860	COG0018	arginyl-trna synthetase
CP966_RS24865	COG0019	diaminopimelate decarboxylase activity
CP966_RS24870	COG0460	homoserine dehydrogenase
CP966_RS24875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP966_RS24880	COG0083	homoserine kinase activity
CP966_RS24900	COG0254	rRNA binding
CP966_RS24905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP966_RS24910	COG2890	protein-(glutamine-N5) methyltransferase activity
CP966_RS24920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP966_RS24925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP966_RS24945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP966_RS24950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP966_RS24955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP966_RS24960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP966_RS24965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP966_RS24970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP966_RS24975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP966_RS24990	COG2197	response regulator
CP966_RS24995	COG4585	Histidine kinase
CP966_RS25020	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CP966_RS25055	COG1131	(ABC) transporter
CP966_RS25075	COG0183	Belongs to the thiolase family
CP966_RS25165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS25165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS25215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CP966_RS25220	COG0857	belongs to the CobB CobQ family
CP966_RS25220	COG0280	phosphate acetyltransferase
CP966_RS25225	COG0205	6-phosphofructokinase activity
CP966_RS25235	COG4565	transcriptional regulatory protein
CP966_RS25240	COG3290	protein histidine kinase activity
CP966_RS25255	COG0477	Major facilitator Superfamily
CP966_RS25275	COG1522	sequence-specific DNA binding
CP966_RS25295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP966_RS25300	COG3281	Trehalose synthase
CP966_RS25305	COG0366	Alpha amylase catalytic
CP966_RS25310	COG0366	Alpha amylase catalytic
CP966_RS25320	COG0058	SHG alpha-glucan phosphorylase activity
CP966_RS25415	COG1132	(ABC) transporter
CP966_RS25420	COG1132	(ABC) transporter
CP966_RS25425	COG1132	(ABC) transporter
CP966_RS25430	COG1132	(ABC) transporter
CP966_RS25445	COG1376	ErfK ybiS ycfS ynhG family protein
CP966_RS25470	COG0789	Transcriptional regulator
CP966_RS25480	COG1119	ATPase activity
CP966_RS25485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP966_RS25495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP966_RS25505	COG1760	l-serine dehydratase
CP966_RS25510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP966_RS25515	COG0509	glycine decarboxylation via glycine cleavage system
CP966_RS25520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP966_RS25540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP966_RS25555	COG0444	Belongs to the ABC transporter superfamily
CP966_RS25560	COG4608	Belongs to the ABC transporter superfamily
CP966_RS25565	COG2860	membrane
CP966_RS25570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CP966_RS25590	COG1309	transcriptional regulator
CP966_RS25605	COG3023	N-Acetylmuramoyl-L-alanine amidase
CP966_RS25610	COG0482	sulfurtransferase activity
CP966_RS25625	COG1611	Belongs to the LOG family
CP966_RS25630	COG4221	oxidoreductase activity
CP966_RS25640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP966_RS25650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP966_RS25655	COG0154	amidase activity
CP966_RS25665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP966_RS25675	COG2409	Drug exporters of the RND superfamily
CP966_RS25680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP966_RS25695	COG1672	PFAM Archaeal ATPase
CP966_RS25695	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP966_RS25710	COG0667	Aldo Keto reductase
CP966_RS25720	COG5001	Diguanylate cyclase
CP966_RS25735	COG0440	acetolactate synthase activity
CP966_RS25740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP966_RS25745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP966_RS25750	COG0477	Major facilitator Superfamily
CP966_RS25760	COG4608	Belongs to the ABC transporter superfamily
CP966_RS25770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP966_RS25775	COG0747	negative chemotaxis
CP966_RS25780	COG2508	Transcriptional regulator
CP966_RS25785	COG0506	proline dehydrogenase activity
CP966_RS25790	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS25805	COG0473	3-isopropylmalate dehydrogenase activity
CP966_RS25810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP966_RS25815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP966_RS25840	COG2353	YceI-like domain
CP966_RS25845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP966_RS25865	COG2018	Roadblock/LC7 domain
CP966_RS25885	COG2018	Roadblock/LC7 domain
CP966_RS25890	COG5002	protein histidine kinase activity
CP966_RS25900	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP966_RS25905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP966_RS25950	COG1414	Transcriptional regulator
CP966_RS25955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP966_RS25960	COG0066	3-isopropylmalate dehydratase activity
CP966_RS25970	COG0776	regulation of translation
CP966_RS25985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP966_RS25990	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP966_RS26010	COG0351	phosphomethylpyrimidine kinase
CP966_RS26015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP966_RS26020	COG1461	Dihydroxyacetone kinase
CP966_RS26030	COG0326	Molecular chaperone. Has ATPase activity
CP966_RS26040	COG0742	ribosomal rna small subunit methyltransferase
CP966_RS26045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP966_RS26060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP966_RS26065	COG0571	ribonuclease III activity
CP966_RS26070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP966_RS26075	COG1733	regulation of RNA biosynthetic process
CP966_RS26080	COG2340	Cysteine-rich secretory protein family
CP966_RS26085	COG1254	Belongs to the acylphosphatase family
CP966_RS26095	COG1196	nuclear chromosome segregation
CP966_RS26100	COG0477	Major facilitator Superfamily
CP966_RS26135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP966_RS26145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP966_RS26155	COG0442	prolyl-tRNA aminoacylation
CP966_RS26165	COG0228	four-way junction DNA binding
CP966_RS26170	COG1837	Belongs to the UPF0109 family
CP966_RS26175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP966_RS26180	COG0336	Belongs to the RNA methyltransferase TrmD family
CP966_RS26185	COG0335	large ribosomal subunit rRNA binding
CP966_RS26200	COG0681	Belongs to the peptidase S26 family
CP966_RS26220	COG0792	nuclease activity
CP966_RS26235	COG1191	sigma factor activity
CP966_RS26250	COG0052	Belongs to the universal ribosomal protein uS2 family
CP966_RS26255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP966_RS26260	COG0528	UMP kinase activity
CP966_RS26265	COG0233	cytoplasmic translational termination
CP966_RS26270	COG0575	Belongs to the CDS family
CP966_RS26360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP966_RS26370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CP966_RS26375	COG3842	ATPase activity
CP966_RS26400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP966_RS26410	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS26450	COG1733	regulation of RNA biosynthetic process
CP966_RS26465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP966_RS26490	COG3842	ATPase activity
CP966_RS26495	COG1176	ABC-type spermidine putrescine transport system, permease component I
CP966_RS26500	COG1177	transmembrane transport
CP966_RS26505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP966_RS26535	COG2508	Transcriptional regulator
CP966_RS26540	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS26545	COG1472	Belongs to the glycosyl hydrolase 3 family
CP966_RS26555	COG1653	transport
CP966_RS26560	COG4209	transmembrane transport
CP966_RS26565	COG0395	ABC-type sugar transport system, permease component
CP966_RS26605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP966_RS26610	COG0750	zinc metalloprotease
CP966_RS26615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP966_RS26645	COG0442	prolyl-tRNA aminoacylation
CP966_RS26665	COG0779	Required for maturation of 30S ribosomal subunits
CP966_RS26680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP966_RS26690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP966_RS26695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP966_RS26710	COG0455	bacterial-type flagellum organization
CP966_RS26730	COG1404	Belongs to the peptidase S8 family
CP966_RS26775	COG1404	Belongs to the peptidase S8 family
CP966_RS26805	COG1674	ftsk spoiiie
CP966_RS26825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP966_RS26830	COG1185	polyribonucleotide nucleotidyltransferase activity
CP966_RS26835	COG0612	Peptidase, M16
CP966_RS26840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP966_RS26860	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CP966_RS26865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP966_RS26870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP966_RS26905	COG2208	phosphoserine phosphatase activity
CP966_RS26905	COG2770	Histidine kinase
CP966_RS26915	COG4999	Histidine kinase
CP966_RS26915	COG3850	Histidine kinase
CP966_RS26915	COG2205	protein histidine kinase activity
CP966_RS26915	COG3437	response regulator, receiver
CP966_RS26925	COG1674	ftsk spoiiie
CP966_RS26935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP966_RS26945	COG1546	Belongs to the CinA family
CP966_RS26945	COG1058	Belongs to the CinA family
CP966_RS26950	COG1396	sequence-specific DNA binding
CP966_RS26955	COG0783	Belongs to the Dps family
CP966_RS26965	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS26970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP966_RS26975	COG1201	RNA secondary structure unwinding
CP966_RS27030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP966_RS27045	COG0765	amino acid transport
CP966_RS27050	COG0765	amino acid transport
CP966_RS27055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP966_RS27060	COG1126	abc transporter atp-binding protein
CP966_RS27065	COG0745	RESPONSE REGULATOR receiver
CP966_RS27070	COG2205	protein histidine kinase activity
CP966_RS27075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP966_RS27100	COG3851	Histidine kinase
CP966_RS27105	COG2197	response regulator
CP966_RS27125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP966_RS27145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP966_RS27160	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP966_RS27165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP966_RS27175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP966_RS27205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP966_RS27210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP966_RS27215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP966_RS27230	COG0588	phosphoglycerate mutase activity
CP966_RS27250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP966_RS27285	COG2186	Transcriptional regulator
CP966_RS27290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP966_RS27305	COG0187	DNA topoisomerase II activity
CP966_RS27320	COG2197	response regulator
CP966_RS27330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP966_RS27335	COG4565	transcriptional regulatory protein
CP966_RS27340	COG3290	protein histidine kinase activity
CP966_RS27355	COG0372	Belongs to the citrate synthase family
CP966_RS27370	COG0523	cobalamin synthesis protein
CP966_RS27375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP966_RS27380	COG0612	Peptidase, M16
CP966_RS27395	COG1802	Transcriptional regulator
CP966_RS27400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP966_RS27425	COG1435	thymidine kinase activity
CP966_RS27465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP966_RS27475	COG0745	RESPONSE REGULATOR receiver
CP966_RS27480	COG2205	protein histidine kinase activity
CP966_RS27505	COG0756	dUTP diphosphatase activity
CP966_RS27545	COG0569	domain protein
CP966_RS27550	COG0531	amino acid
CP966_RS27555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP966_RS27560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS27570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS27575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP966_RS27640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP966_RS27670	COG2353	YceI-like domain
CP966_RS27675	COG1799	cell septum assembly
CP966_RS27705	COG2226	methyltransferase
CP966_RS27710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP966_RS27725	COG2235	arginine
CP966_RS27730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP966_RS27740	COG1024	Enoyl-CoA hydratase
CP966_RS27745	COG1902	pentaerythritol trinitrate reductase activity
CP966_RS27780	COG0697	spore germination
CP966_RS27800	COG3851	Histidine kinase
CP966_RS27805	COG2197	response regulator
CP966_RS27815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP966_RS27845	COG0367	asparagine synthase
CP966_RS27900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP966_RS27910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP966_RS27920	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS28005	COG3458	cephalosporin-C deacetylase activity
CP966_RS28010	COG4209	transmembrane transport
CP966_RS28015	COG0395	ABC-type sugar transport system, permease component
CP966_RS28060	COG1653	transport
CP966_RS28065	COG1175	transmembrane transport
CP966_RS28070	COG0395	ABC-type sugar transport system, permease component
CP966_RS28075	COG1940	carbohydrate kinase activity
CP966_RS28080	COG4213	ABC transporter substrate-binding protein
CP966_RS28090	COG4214	carbohydrate transport
CP966_RS28095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP966_RS28100	COG0531	amino acid
CP966_RS28115	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP966_RS28115	COG1024	Enoyl-CoA hydratase
CP966_RS28120	COG0183	Belongs to the thiolase family
CP966_RS28140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP966_RS28155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP966_RS28190	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP966_RS28205	COG3253	May function as heme-dependent peroxidase
CP966_RS28225	COG3220	belongs to the UPF0276 family
CP966_RS28265	COG0330	HflC and HflK could
CP966_RS28300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP966_RS28305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP966_RS28315	COG2205	protein histidine kinase activity
CP966_RS28320	COG0745	RESPONSE REGULATOR receiver
CP966_RS28340	COG1733	regulation of RNA biosynthetic process
CP966_RS28370	COG1174	glycine betaine transport
CP966_RS28395	COG2018	Roadblock/LC7 domain
CP966_RS28400	COG5002	protein histidine kinase activity
CP966_RS28445	COG1404	Belongs to the peptidase S8 family
CP966_RS28475	COG0504	CTP synthase activity
CP966_RS28590	COG1116	anion transmembrane transporter activity
CP966_RS28615	COG0529	Catalyzes the synthesis of activated sulfate
CP966_RS28620	COG0175	sulfate reduction
CP966_RS28650	COG1960	acyl-CoA dehydrogenase activity
CP966_RS28665	COG1917	Cupin 2, conserved barrel domain protein
CP966_RS28665	COG4977	sequence-specific DNA binding
CP966_RS28695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CP966_RS28705	COG1733	regulation of RNA biosynthetic process
CP966_RS28725	COG2040	homocysteine
CP966_RS28730	COG0531	amino acid
CP966_RS28750	COG2755	lipolytic protein G-D-S-L family
CP966_RS28770	COG1309	transcriptional regulator
CP966_RS28795	COG0477	Major facilitator Superfamily
CP966_RS28820	COG0277	FAD linked oxidase domain protein
CP966_RS28835	COG3540	Alkaline phosphatase
CP966_RS28855	COG1162	GTPase activity
CP966_RS28865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP966_RS28890	COG0028	Belongs to the TPP enzyme family
CP966_RS28920	COG1802	Transcriptional regulator
CP966_RS28945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP966_RS28950	COG2252	PERMEase
CP966_RS28970	COG3940	Belongs to the glycosyl hydrolase 43 family
CP966_RS28995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP966_RS29000	COG2197	response regulator
CP966_RS29005	COG4585	Histidine kinase
CP966_RS29060	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CP966_RS29120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP966_RS29135	COG3321	synthase
CP966_RS29135	COG0604	alcohol dehydrogenase
CP966_RS29170	COG0702	epimerase
CP966_RS29210	COG2197	response regulator
CP966_RS29215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP966_RS29220	COG0318	PFAM AMP-dependent synthetase and ligase
CP966_RS29230	COG3960	tartronate-semialdehyde synthase activity
CP966_RS29245	COG2084	Dehydrogenase
CP966_RS29250	COG3622	Belongs to the hyi family
CP966_RS29270	COG2351	hydroxyisourate hydrolase activity
CP966_RS29285	COG2233	PERMEase
CP966_RS29295	COG0702	epimerase
CP966_RS29305	COG1733	regulation of RNA biosynthetic process
CP966_RS29320	COG0406	alpha-ribazole phosphatase activity
CP966_RS29345	COG0436	Aminotransferase
CP966_RS29380	COG0583	DNA-binding transcription factor activity
CP966_RS29385	COG0483	inositol monophosphate 1-phosphatase activity
CP966_RS29400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP966_RS29415	COG1414	Transcriptional regulator
CP966_RS29420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP966_RS29425	COG4266	Belongs to the allantoicase family
CP966_RS29430	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS29460	COG2197	response regulator
CP966_RS29465	COG0673	inositol 2-dehydrogenase activity
CP966_RS29470	COG2188	Transcriptional regulator
CP966_RS29490	COG1940	carbohydrate kinase activity
CP966_RS29500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP966_RS29515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP966_RS29520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP966_RS29525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP966_RS29530	COG0708	Exodeoxyribonuclease III
CP966_RS29540	COG1126	abc transporter atp-binding protein
CP966_RS29555	COG0405	Gamma-glutamyltransferase
CP966_RS29560	COG0542	response to heat
CP966_RS29590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP966_RS29600	COG1953	Uracil, thiamine, allantoin
CP966_RS29625	COG0483	inositol monophosphate 1-phosphatase activity
CP966_RS29635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CP966_RS29640	COG0243	molybdopterin cofactor binding
CP966_RS29660	COG0640	Transcriptional regulator
CP966_RS29690	COG3250	beta-galactosidase activity
CP966_RS29700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP966_RS29710	COG0494	nUDIX hydrolase
CP966_RS29720	COG1929	Belongs to the glycerate kinase type-1 family
CP966_RS29735	COG0688	phosphatidylethanolamine metabolic process
CP966_RS29740	COG1960	acyl-CoA dehydrogenase activity
CP966_RS29750	COG2301	Belongs to the HpcH HpaI aldolase family
CP966_RS29755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS29755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP966_RS29760	COG0604	alcohol dehydrogenase
CP966_RS29770	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP966_RS29780	COG0456	acetyltransferase
CP966_RS29790	COG0596	Alpha beta hydrolase
CP966_RS29810	COG2172	sigma factor antagonist activity
CP966_RS29810	COG1366	Belongs to the anti-sigma-factor antagonist family
CP966_RS29810	COG2208	phosphoserine phosphatase activity
CP966_RS29815	COG2226	methyltransferase
CP966_RS29830	COG2362	D-Aminopeptidase
CP966_RS29835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP966_RS29845	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP966_RS29870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS29945	COG2226	methyltransferase
CP966_RS29950	COG0406	alpha-ribazole phosphatase activity
CP966_RS29955	COG0488	(ABC) transporter
CP966_RS29965	COG0693	protein deglycase activity
CP966_RS29975	COG0028	Belongs to the TPP enzyme family
CP966_RS30065	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP966_RS30070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP966_RS30070	COG4106	trans-aconitate 2-methyltransferase activity
CP966_RS30085	COG2378	regulation of single-species biofilm formation
CP966_RS30090	COG3401	FG-GAP repeat protein
CP966_RS30100	COG4733	cellulase activity
CP966_RS30100	COG5297	Belongs to the glycosyl hydrolase family 6
CP966_RS30110	COG5297	Belongs to the glycosyl hydrolase family 6
CP966_RS30120	COG0656	L-ascorbic acid biosynthetic process
CP966_RS30130	COG0583	DNA-binding transcription factor activity
CP966_RS30140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP966_RS30150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP966_RS30155	COG3383	formate dehydrogenase (NAD+) activity
CP966_RS30160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP966_RS30175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP966_RS30190	COG1129	ABC transporter
CP966_RS30195	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP966_RS30205	COG0673	inositol 2-dehydrogenase activity
CP966_RS30215	COG3507	Belongs to the glycosyl hydrolase 43 family
CP966_RS30265	COG2223	nitrite transmembrane transporter activity
CP966_RS30275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP966_RS30285	COG0045	succinate-CoA ligase (ADP-forming) activity
CP966_RS30295	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS30335	COG2072	flavoprotein involved in K transport
CP966_RS30345	COG3938	Belongs to the proline racemase family
CP966_RS30350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP966_RS30365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP966_RS30380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP966_RS30385	COG2182	Extracellular solute-binding protein
CP966_RS30390	COG1175	transmembrane transport
CP966_RS30395	COG0395	ABC-type sugar transport system, permease component
CP966_RS30400	COG2723	6-phospho-beta-galactosidase activity
CP966_RS30410	COG1733	regulation of RNA biosynthetic process
CP966_RS30420	COG2267	carboxylic ester hydrolase activity
CP966_RS30435	COG0747	negative chemotaxis
CP966_RS30465	COG0297	glycogen (starch) synthase activity
CP966_RS30485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP966_RS30510	COG0477	Major facilitator Superfamily
CP966_RS30520	COG3467	pyridoxamine 5'-phosphate
CP966_RS30525	COG0477	Major facilitator Superfamily
CP966_RS30535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP966_RS30540	COG1082	Xylose isomerase domain protein TIM barrel
CP966_RS30540	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP966_RS30550	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP966_RS30555	COG0166	Belongs to the GPI family
CP966_RS30590	COG1937	Protein conserved in bacteria
CP966_RS30610	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS30645	COG3250	beta-galactosidase activity
CP966_RS30650	COG0395	ABC-type sugar transport system, permease component
CP966_RS30655	COG1175	transmembrane transport
CP966_RS30665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP966_RS30675	COG1486	melibiose metabolic process
CP966_RS30695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP966_RS30750	COG3511	phospholipase C
CP966_RS30785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP966_RS30790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP966_RS30795	COG3485	protocatechuate 3,4-dioxygenase
CP966_RS30800	COG3485	protocatechuate 3,4-dioxygenase
CP966_RS30820	COG1793	dna ligase
CP966_RS30900	COG1834	amidinotransferase
CP966_RS30905	COG0488	(ABC) transporter
CP966_RS30930	COG1515	deoxyribonuclease V activity
CP966_RS30945	COG3268	Saccharopine dehydrogenase
CP966_RS30955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP966_RS30960	COG0183	Belongs to the thiolase family
CP966_RS30965	COG1024	Enoyl-CoA hydratase
CP966_RS30965	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP966_RS31005	COG3903	Transcriptional regulator
CP966_RS31005	COG3629	intracellular signal transduction
CP966_RS31010	COG2304	oxidoreductase activity
CP966_RS31035	COG2986	histidine ammonia-lyase
CP966_RS31060	COG0488	(ABC) transporter
CP966_RS31065	COG2183	response to ionizing radiation
CP966_RS31070	COG4977	sequence-specific DNA binding
CP966_RS31080	COG1024	Enoyl-CoA hydratase
CP966_RS31095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP966_RS31140	COG1134	teichoic acid transport
CP966_RS31145	COG1562	ergosterol biosynthetic process
CP966_RS31155	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP966_RS31165	COG1657	PFAM Prenyltransferase squalene oxidase
CP966_RS31180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP966_RS31205	COG2365	Tyrosine phosphatase family
CP966_RS31225	COG2755	lipolytic protein G-D-S-L family
CP966_RS31280	COG1063	alcohol dehydrogenase
CP966_RS31285	COG0156	8-amino-7-oxononanoate synthase activity
CP966_RS31290	COG0583	DNA-binding transcription factor activity
CP966_RS31320	COG0586	Pfam SNARE associated Golgi protein
CP966_RS31325	COG1132	(ABC) transporter
CP966_RS31340	COG0561	phosphatase activity
CP966_RS31345	COG2197	response regulator
CP966_RS31355	COG1136	(ABC) transporter
CP966_RS31365	COG1473	amidohydrolase
CP966_RS31385	COG0183	Belongs to the thiolase family
CP966_RS31430	COG1960	acyl-CoA dehydrogenase activity
CP966_RS31440	COG2188	Transcriptional regulator
CP966_RS31465	COG0673	inositol 2-dehydrogenase activity
CP966_RS31480	COG1609	Transcriptional regulator
CP966_RS31485	COG0673	inositol 2-dehydrogenase activity
CP966_RS31490	COG1609	Transcriptional regulator
CP966_RS31505	COG0579	oxidoreductase
CP966_RS31520	COG1819	glycosyl
CP966_RS31525	COG0596	Alpha beta hydrolase
CP966_RS31555	COG0235	Class ii aldolase
CP966_RS31580	COG1126	abc transporter atp-binding protein
CP966_RS31585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP966_RS31595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS31600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS31610	COG2197	response regulator
CP966_RS31640	COG2838	Isocitrate dehydrogenase
CP966_RS31645	COG0668	transmembrane transport
CP966_RS31650	COG0531	amino acid
CP966_RS31660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP966_RS31665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP966_RS31665	COG2022	thiamine diphosphate biosynthetic process
CP966_RS31685	COG1132	(ABC) transporter
CP966_RS31690	COG5006	permease, DMT superfamily
CP966_RS31705	COG2315	Protein conserved in bacteria
CP966_RS31710	COG2315	Protein conserved in bacteria
CP966_RS31745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP966_RS31750	COG1725	Transcriptional regulator
CP966_RS31755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CP966_RS31765	COG1132	(ABC) transporter
CP966_RS31775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP966_RS31790	COG3424	synthase
CP966_RS31795	COG1024	Enoyl-CoA hydratase
CP966_RS31800	COG1024	Enoyl-CoA hydratase
CP966_RS31805	COG1278	Cold shock
CP966_RS31840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP966_RS31880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP966_RS31900	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CP966_RS31920	COG0297	glycogen (starch) synthase activity
CP966_RS31925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP966_RS31955	COG2186	Transcriptional regulator
CP966_RS31960	COG4948	Mandelate Racemase Muconate Lactonizing
CP966_RS31965	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS31990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP966_RS32020	COG0726	polysaccharide deacetylase
CP966_RS32070	COG0583	DNA-binding transcription factor activity
CP966_RS32080	COG1053	succinate dehydrogenase
CP966_RS32085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP966_RS32105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS32115	COG3360	Dodecin
CP966_RS32120	COG2182	Extracellular solute-binding protein
CP966_RS32125	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP966_RS32135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP966_RS32165	COG1511	domain protein
CP966_RS32210	COG0477	Major facilitator Superfamily
CP966_RS32215	COG2197	response regulator
CP966_RS32245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP966_RS32260	COG1609	Transcriptional regulator
CP966_RS32270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP966_RS32280	COG0242	peptide deformylase activity
CP966_RS32305	COG2824	Alkylphosphonate utilization operon protein PhnA
CP966_RS32315	COG0659	secondary active sulfate transmembrane transporter activity
CP966_RS32345	COG1621	beta-fructofuranosidase activity
CP966_RS32350	COG0395	ABC-type sugar transport system, permease component
CP966_RS32355	COG1175	transmembrane transport
CP966_RS32365	COG1609	Transcriptional regulator
CP966_RS32370	COG1621	beta-fructofuranosidase activity
CP966_RS32390	COG1132	(ABC) transporter
CP966_RS32450	COG0542	response to heat
CP966_RS32460	COG0702	epimerase
CP966_RS32470	COG0723	plastoquinol--plastocyanin reductase activity
CP966_RS32470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP966_RS32475	COG1556	Lactate utilization protein
CP966_RS32480	COG1139	Iron-sulfur cluster binding protein
CP966_RS32485	COG0247	lactate metabolic process
CP966_RS32490	COG1070	Carbohydrate kinase
CP966_RS32495	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS32495	COG3347	Dehydrogenase
CP966_RS32505	COG1129	ABC transporter
CP966_RS32510	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP966_RS32520	COG1879	ABC-type sugar transport system periplasmic component
CP966_RS32535	COG1609	Transcriptional regulator
CP966_RS32555	COG1357	PFAM Pentapeptide repeats (8 copies)
CP966_RS32565	COG1309	transcriptional regulator
CP966_RS32575	COG2706	6-phosphogluconolactonase activity
CP966_RS32620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CP966_RS32620	COG1796	DNA polymerase
CP966_RS32625	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS32650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP966_RS32660	COG1846	Transcriptional regulator
CP966_RS32665	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS32715	COG0435	Glutathione S-transferase
CP966_RS32730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP966_RS32740	COG0667	Aldo Keto reductase
CP966_RS32760	COG3250	beta-galactosidase activity
CP966_RS32800	COG2890	protein-(glutamine-N5) methyltransferase activity
CP966_RS32820	COG0248	Ppx GppA phosphatase
CP966_RS32880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CP966_RS32915	COG1132	(ABC) transporter
CP966_RS32930	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS32980	COG1309	transcriptional regulator
CP966_RS32985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP966_RS33000	COG5002	protein histidine kinase activity
CP966_RS33000	COG5001	Diguanylate cyclase
CP966_RS33000	COG3447	MASE1 domain protein
CP966_RS33025	COG1940	carbohydrate kinase activity
CP966_RS33030	COG1653	transport
CP966_RS33035	COG1175	transmembrane transport
CP966_RS33040	COG0395	ABC-type sugar transport system, permease component
CP966_RS33080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP966_RS33085	COG3340	Belongs to the peptidase S51 family
CP966_RS33120	COG2261	transglycosylase associated protein
CP966_RS33145	COG2508	Transcriptional regulator
CP966_RS33150	COG0410	ABC transporter
CP966_RS33155	COG0411	ABC transporter
CP966_RS33160	COG0559	Belongs to the binding-protein-dependent transport system permease family
CP966_RS33175	COG1132	(ABC) transporter
CP966_RS33205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP966_RS33210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP966_RS33215	COG2080	2 iron, 2 sulfur cluster binding
CP966_RS33235	COG0515	serine threonine protein kinase
CP966_RS33245	COG3290	protein histidine kinase activity
CP966_RS33260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP966_RS33265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP966_RS33285	COG1597	lipid kinase activity
CP966_RS33315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP966_RS33330	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP966_RS33335	COG0714	Associated with various cellular activities
CP966_RS33370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CP966_RS33375	COG2197	response regulator
CP966_RS33395	COG0739	heme binding
CP966_RS33460	COG0395	ABC-type sugar transport system, permease component
CP966_RS33465	COG4209	transmembrane transport
CP966_RS33510	COG0328	RNA-DNA hybrid ribonuclease activity
CP966_RS33535	COG0667	Aldo Keto reductase
CP966_RS33580	COG2340	Cysteine-rich secretory protein family
CP966_RS33585	COG1672	PFAM Archaeal ATPase
CP966_RS33585	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CP966_RS33655	COG0702	epimerase
CP966_RS33670	COG0583	DNA-binding transcription factor activity
CP966_RS33685	COG1595	DNA-templated transcription, initiation
CP966_RS33690	COG1252	NADH dehydrogenase
CP966_RS33695	COG1522	sequence-specific DNA binding
CP966_RS33720	COG1902	pentaerythritol trinitrate reductase activity
CP966_RS33730	COG1012	belongs to the aldehyde dehydrogenase family
CP966_RS33785	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP966_RS33820	COG0789	Transcriptional regulator
CP966_RS33940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP966_RS33960	COG3189	MarR family transcriptional regulator
CP966_RS33980	COG5002	protein histidine kinase activity
CP966_RS34065	COG2172	sigma factor antagonist activity
CP966_RS34070	COG1366	Belongs to the anti-sigma-factor antagonist family
CP966_RS34075	COG1366	Belongs to the anti-sigma-factor antagonist family
CP966_RS34085	COG1191	sigma factor activity
CP966_RS34115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP966_RS34120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP966_RS34135	COG0366	Alpha amylase catalytic
CP966_RS34175	COG2197	response regulator
CP966_RS34180	COG4585	Histidine kinase
CP966_RS34190	COG0181	hydroxymethylbilane synthase activity
CP966_RS34215	COG2197	response regulator
CP966_RS34295	COG0009	L-threonylcarbamoyladenylate synthase
CP966_RS34305	COG0477	Major facilitator Superfamily
CP966_RS34315	COG2124	cytochrome p450
CP966_RS34385	COG0475	glutathione-regulated potassium exporter activity
CP966_RS34395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP966_RS34400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP966_RS34470	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS34510	COG1846	Transcriptional regulator
CP966_RS34510	COG1940	carbohydrate kinase activity
CP966_RS34600	COG0326	Molecular chaperone. Has ATPase activity
CP966_RS34625	COG0515	serine threonine protein kinase
CP966_RS34640	COG1396	sequence-specific DNA binding
CP966_RS34655	COG2340	Cysteine-rich secretory protein family
CP966_RS34690	COG0640	Transcriptional regulator
CP966_RS34700	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS34705	COG0137	argininosuccinate synthase activity
CP966_RS34710	COG1982	Orn Lys Arg decarboxylase major
CP966_RS34725	COG3152	Membrane
CP966_RS34730	COG4977	sequence-specific DNA binding
CP966_RS34770	COG0745	RESPONSE REGULATOR receiver
CP966_RS34775	COG5002	protein histidine kinase activity
CP966_RS34820	COG1175	transmembrane transport
CP966_RS34825	COG0395	ABC-type sugar transport system, permease component
CP966_RS34830	COG0366	Alpha amylase catalytic
CP966_RS34840	COG4305	rare lipoprotein A
CP966_RS34855	COG0494	nUDIX hydrolase
CP966_RS34865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP966_RS34870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP966_RS34880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP966_RS34915	COG0277	FAD linked oxidase domain protein
CP966_RS34920	COG1597	lipid kinase activity
CP966_RS34930	COG1609	Transcriptional regulator
CP966_RS34940	COG1175	transmembrane transport
CP966_RS34950	COG3250	beta-galactosidase activity
CP966_RS34995	COG0513	Belongs to the DEAD box helicase family
CP966_RS35015	COG2197	response regulator
CP966_RS35020	COG4585	Histidine kinase
CP966_RS35025	COG2409	Drug exporters of the RND superfamily
CP966_RS35030	COG0583	DNA-binding transcription factor activity
CP966_RS35050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP966_RS35060	COG2308	Evidence 4 Homologs of previously reported genes of
CP966_RS35060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP966_RS35090	COG2267	carboxylic ester hydrolase activity
CP966_RS35140	COG0667	Aldo Keto reductase
CP966_RS35190	COG1028	Short-chain dehydrogenase reductase Sdr
CP966_RS35200	COG4941	Belongs to the sigma-70 factor family
CP966_RS35205	COG3795	YCII-related domain
CP966_RS35230	COG2267	carboxylic ester hydrolase activity
CP966_RS35235	COG0738	Major facilitator superfamily