locus-tag	class	description
H4W23_RS00175	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H4W23_RS00175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4W23_RS00320	COG2319	Wd-40 repeat
H4W23_RS00320	COG4249	Peptidase C14 caspase catalytic subunit p20
H4W23_RS00495	COG2226	methyltransferase
H4W23_RS00665	COG2197	response regulator
H4W23_RS00685	COG4585	Histidine kinase
H4W23_RS00690	COG2197	response regulator
H4W23_RS00730	COG0604	alcohol dehydrogenase
H4W23_RS00895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4W23_RS00955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4W23_RS01010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4W23_RS01020	COG2197	response regulator
H4W23_RS01085	COG0640	Transcriptional regulator
H4W23_RS01120	COG0583	DNA-binding transcription factor activity
H4W23_RS01125	COG4221	oxidoreductase activity
H4W23_RS01135	COG3340	Belongs to the peptidase S51 family
H4W23_RS01160	COG0604	alcohol dehydrogenase
H4W23_RS01160	COG3321	synthase
H4W23_RS01160	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS01170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4W23_RS01205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4W23_RS01265	COG4221	oxidoreductase activity
H4W23_RS01305	COG3842	ATPase activity
H4W23_RS01310	COG1178	ABC-type Fe3 transport system permease component
H4W23_RS01315	COG1840	ABC-type Fe3 transport system, periplasmic component
H4W23_RS01320	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS01355	COG0667	Aldo Keto reductase
H4W23_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS01475	COG0577	efflux transmembrane transporter activity
H4W23_RS01475	COG1136	(ABC) transporter
H4W23_RS01490	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS01495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W23_RS01555	COG1802	Transcriptional regulator
H4W23_RS01560	COG0395	ABC-type sugar transport system, permease component
H4W23_RS01565	COG1175	transmembrane transport
H4W23_RS01570	COG1653	transport
H4W23_RS01580	COG4948	Mandelate Racemase Muconate Lactonizing
H4W23_RS01585	COG0477	Major facilitator Superfamily
H4W23_RS01600	COG0800	Aldolase
H4W23_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS01610	COG1802	Transcriptional regulator
H4W23_RS01640	COG1597	lipid kinase activity
H4W23_RS01645	COG0277	FAD linked oxidase domain protein
H4W23_RS01660	COG1011	Hydrolase
H4W23_RS01735	COG1414	Transcriptional regulator
H4W23_RS01795	COG0477	Major facilitator Superfamily
H4W23_RS01820	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H4W23_RS01870	COG0667	Aldo Keto reductase
H4W23_RS01880	COG2197	response regulator
H4W23_RS01885	COG4585	Histidine kinase
H4W23_RS01890	COG2409	Drug exporters of the RND superfamily
H4W23_RS01940	COG2318	DinB family
H4W23_RS01985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4W23_RS01990	COG0596	Alpha beta hydrolase
H4W23_RS02015	COG1309	transcriptional regulator
H4W23_RS02035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS02040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS02045	COG0456	acetyltransferase
H4W23_RS02060	COG2197	response regulator
H4W23_RS02065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H4W23_RS02075	COG0697	spore germination
H4W23_RS02085	COG0137	argininosuccinate synthase activity
H4W23_RS02090	COG1834	amidinotransferase
H4W23_RS02120	COG0154	amidase activity
H4W23_RS02125	COG0284	orotidine-5'-phosphate decarboxylase activity
H4W23_RS02235	COG0640	Transcriptional regulator
H4W23_RS02245	COG1247	-acetyltransferase
H4W23_RS02250	COG0640	Transcriptional regulator
H4W23_RS02255	COG0640	Transcriptional regulator
H4W23_RS02265	COG0456	acetyltransferase
H4W23_RS02265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4W23_RS02280	COG2072	flavoprotein involved in K transport
H4W23_RS02285	COG0798	PFAM Bile acid sodium symporter
H4W23_RS02295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4W23_RS02300	COG0492	ferredoxin-NADP+ reductase activity
H4W23_RS02305	COG0640	Transcriptional regulator
H4W23_RS02310	COG0640	Transcriptional regulator
H4W23_RS02315	COG2226	methyltransferase
H4W23_RS02340	COG0573	inorganic phosphate transmembrane transporter activity
H4W23_RS02345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4W23_RS02355	COG0366	Alpha amylase catalytic
H4W23_RS02370	COG0395	ABC-type sugar transport system, permease component
H4W23_RS02375	COG1175	transmembrane transport
H4W23_RS02380	COG1653	transport
H4W23_RS02385	COG1940	carbohydrate kinase activity
H4W23_RS02385	COG1846	Transcriptional regulator
H4W23_RS02435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4W23_RS02455	COG1609	Transcriptional regulator
H4W23_RS02500	COG2508	Transcriptional regulator
H4W23_RS02505	COG3585	molybdate ion transport
H4W23_RS02515	COG0259	pyridoxamine-phosphate oxidase activity
H4W23_RS02525	COG2226	methyltransferase
H4W23_RS02530	COG3291	Pkd domain containing protein
H4W23_RS02550	COG1819	glycosyl
H4W23_RS02575	COG3263	regulation of cellular component size
H4W23_RS02605	COG2267	carboxylic ester hydrolase activity
H4W23_RS02655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H4W23_RS02665	COG2267	carboxylic ester hydrolase activity
H4W23_RS02705	COG2188	Transcriptional regulator
H4W23_RS02710	COG2182	Extracellular solute-binding protein
H4W23_RS02715	COG1175	transmembrane transport
H4W23_RS02720	COG0395	ABC-type sugar transport system, permease component
H4W23_RS02725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4W23_RS02740	COG1309	transcriptional regulator
H4W23_RS02745	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS02790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4W23_RS02800	COG1802	Transcriptional regulator
H4W23_RS02840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS02845	COG0601	transmembrane transport
H4W23_RS02855	COG4608	Belongs to the ABC transporter superfamily
H4W23_RS02920	COG0583	DNA-binding transcription factor activity
H4W23_RS02930	COG3896	Chloramphenicol phosphotransferase-like protein
H4W23_RS02955	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS02965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4W23_RS02965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4W23_RS02990	COG1024	Enoyl-CoA hydratase
H4W23_RS03000	COG0328	RNA-DNA hybrid ribonuclease activity
H4W23_RS03070	COG0252	asparaginase activity
H4W23_RS03080	COG2356	endonuclease I
H4W23_RS03085	COG0456	acetyltransferase
H4W23_RS03095	COG1917	Cupin 2, conserved barrel domain protein
H4W23_RS03100	COG5285	phytanoyl-CoA dioxygenase
H4W23_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS03110	COG0765	amino acid transport
H4W23_RS03115	COG0765	amino acid transport
H4W23_RS03120	COG1126	abc transporter atp-binding protein
H4W23_RS03125	COG1191	sigma factor activity
H4W23_RS03140	COG3693	PFAM glycoside hydrolase, family 10
H4W23_RS03155	COG0673	inositol 2-dehydrogenase activity
H4W23_RS03170	COG0395	ABC-type sugar transport system, permease component
H4W23_RS03175	COG1175	transmembrane transport
H4W23_RS03190	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W23_RS03195	COG3507	Belongs to the glycosyl hydrolase 43 family
H4W23_RS03210	COG2160	L-arabinose isomerase activity
H4W23_RS03220	COG1609	Transcriptional regulator
H4W23_RS03235	COG4214	carbohydrate transport
H4W23_RS03245	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS03250	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS03260	COG1879	ABC-type sugar transport system periplasmic component
H4W23_RS03265	COG1063	alcohol dehydrogenase
H4W23_RS03300	COG2124	cytochrome p450
H4W23_RS03305	COG2124	cytochrome p450
H4W23_RS03310	COG0142	geranyltranstransferase activity
H4W23_RS03380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4W23_RS03385	COG2867	negative regulation of translational initiation
H4W23_RS03425	COG2304	oxidoreductase activity
H4W23_RS03440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W23_RS03445	COG2814	Major facilitator Superfamily
H4W23_RS03450	COG0789	Transcriptional regulator
H4W23_RS03460	COG2010	Cytochrome c
H4W23_RS03460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4W23_RS03465	COG4106	trans-aconitate 2-methyltransferase activity
H4W23_RS03470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4W23_RS03470	COG0519	Catalyzes the synthesis of GMP from XMP
H4W23_RS03490	COG2272	Belongs to the type-B carboxylesterase lipase family
H4W23_RS03530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4W23_RS03540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS03550	COG0747	negative chemotaxis
H4W23_RS03575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4W23_RS03605	COG0640	Transcriptional regulator
H4W23_RS03610	COG2814	Major facilitator Superfamily
H4W23_RS03620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4W23_RS03625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4W23_RS03660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4W23_RS03735	COG1024	Enoyl-CoA hydratase
H4W23_RS03750	COG1357	PFAM Pentapeptide repeats (8 copies)
H4W23_RS03765	COG2124	cytochrome p450
H4W23_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS03795	COG2366	antibiotic biosynthetic process
H4W23_RS03805	COG1846	Transcriptional regulator
H4W23_RS03825	COG2070	2-Nitropropane dioxygenase
H4W23_RS03830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W23_RS03840	COG0596	Alpha beta hydrolase
H4W23_RS03845	COG0583	DNA-binding transcription factor activity
H4W23_RS03850	COG0156	8-amino-7-oxononanoate synthase activity
H4W23_RS03855	COG1063	alcohol dehydrogenase
H4W23_RS03870	COG0515	serine threonine protein kinase
H4W23_RS03900	COG0714	Associated with various cellular activities
H4W23_RS03910	COG0542	response to heat
H4W23_RS03935	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS03945	COG1132	(ABC) transporter
H4W23_RS03945	COG2375	cellular response to nickel ion
H4W23_RS03960	COG1796	DNA polymerase
H4W23_RS03960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4W23_RS03990	COG1716	ATPase activity
H4W23_RS03990	COG1131	(ABC) transporter
H4W23_RS03990	COG0842	Transport permease protein
H4W23_RS04020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS04030	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS04035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W23_RS04065	COG0517	IMP dehydrogenase activity
H4W23_RS04065	COG0516	GMP reductase activity
H4W23_RS04080	COG0137	argininosuccinate synthase activity
H4W23_RS04115	COG0730	response to heat
H4W23_RS04130	COG1132	(ABC) transporter
H4W23_RS04150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4W23_RS04160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H4W23_RS04165	COG0557	exoribonuclease II activity
H4W23_RS04190	COG0598	Magnesium transport protein CorA
H4W23_RS04195	COG1742	UPF0060 membrane protein
H4W23_RS04200	COG2957	Belongs to the agmatine deiminase family
H4W23_RS04230	COG2197	response regulator
H4W23_RS04235	COG4585	Histidine kinase
H4W23_RS04240	COG0517	IMP dehydrogenase activity
H4W23_RS04240	COG0516	GMP reductase activity
H4W23_RS04275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS04280	COG1063	alcohol dehydrogenase
H4W23_RS04290	COG0517	IMP dehydrogenase activity
H4W23_RS04290	COG0516	GMP reductase activity
H4W23_RS04300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4W23_RS04315	COG0071	Belongs to the small heat shock protein (HSP20) family
H4W23_RS04330	COG0517	IMP dehydrogenase activity
H4W23_RS04330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4W23_RS04340	COG1136	(ABC) transporter
H4W23_RS04365	COG0583	DNA-binding transcription factor activity
H4W23_RS04405	COG1136	(ABC) transporter
H4W23_RS04425	COG2376	Dihydroxyacetone kinase
H4W23_RS04430	COG1461	Dihydroxyacetone kinase
H4W23_RS04440	COG0640	Transcriptional regulator
H4W23_RS04445	COG0346	lactoylglutathione lyase activity
H4W23_RS04455	COG0310	cobalt ion transport
H4W23_RS04460	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
H4W23_RS04470	COG1122	ATPase activity
H4W23_RS04475	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4W23_RS04475	COG1902	pentaerythritol trinitrate reductase activity
H4W23_RS04490	COG0640	Transcriptional regulator
H4W23_RS04510	COG3401	FG-GAP repeat protein
H4W23_RS04550	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4W23_RS04550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4W23_RS04565	COG2124	cytochrome p450
H4W23_RS04575	COG1686	Belongs to the peptidase S11 family
H4W23_RS04580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4W23_RS04615	COG2340	Cysteine-rich secretory protein family
H4W23_RS04630	COG2838	Isocitrate dehydrogenase
H4W23_RS04640	COG3387	PFAM Glycoside hydrolase 15-related
H4W23_RS04655	COG0297	glycogen (starch) synthase activity
H4W23_RS04715	COG0138	bifunctional purine biosynthesis protein purh
H4W23_RS04730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4W23_RS04745	COG2837	iron assimilation
H4W23_RS04765	COG0303	'Molybdopterin
H4W23_RS04780	COG1024	Enoyl-CoA hydratase
H4W23_RS04785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4W23_RS04790	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS04810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W23_RS04820	COG1120	ATPase activity
H4W23_RS04825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS04830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS04840	COG1132	(ABC) transporter
H4W23_RS04860	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H4W23_RS04865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4W23_RS04865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4W23_RS04870	COG1834	amidinotransferase
H4W23_RS04905	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H4W23_RS04955	COG2409	Drug exporters of the RND superfamily
H4W23_RS04990	COG2723	6-phospho-beta-galactosidase activity
H4W23_RS04995	COG0395	ABC-type sugar transport system, permease component
H4W23_RS05000	COG1175	transmembrane transport
H4W23_RS05005	COG2182	Extracellular solute-binding protein
H4W23_RS05010	COG1940	carbohydrate kinase activity
H4W23_RS05030	COG2207	Transcriptional regulator
H4W23_RS05050	COG1309	transcriptional regulator
H4W23_RS05060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS05070	COG3321	synthase
H4W23_RS05070	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS05070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4W23_RS05070	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS05070	COG0300	oxidoreductase activity
H4W23_RS05095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS05100	COG1595	DNA-templated transcription, initiation
H4W23_RS05115	COG2226	methyltransferase
H4W23_RS05120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4W23_RS05120	COG2226	methyltransferase
H4W23_RS05120	COG3433	isochorismatase activity
H4W23_RS05125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4W23_RS05160	COG1695	Transcriptional regulator
H4W23_RS05200	COG1846	Transcriptional regulator
H4W23_RS05210	COG2409	Drug exporters of the RND superfamily
H4W23_RS05225	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4W23_RS05250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4W23_RS05265	COG2890	protein-(glutamine-N5) methyltransferase activity
H4W23_RS05285	COG1755	Isoprenylcysteine carboxyl methyltransferase
H4W23_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS05330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4W23_RS05360	COG0464	growth
H4W23_RS05370	COG1349	DNA-binding transcription factor activity
H4W23_RS05435	COG1940	carbohydrate kinase activity
H4W23_RS05445	COG2223	nitrite transmembrane transporter activity
H4W23_RS05465	COG2197	response regulator
H4W23_RS05470	COG4585	Histidine kinase
H4W23_RS05505	COG1660	Displays ATPase and GTPase activities
H4W23_RS05520	COG0515	serine threonine protein kinase
H4W23_RS05530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H4W23_RS05550	COG0204	Acyl-transferase
H4W23_RS05590	COG0671	phosphoesterase, PA-phosphatase related
H4W23_RS05610	COG0640	Transcriptional regulator
H4W23_RS05615	COG1902	pentaerythritol trinitrate reductase activity
H4W23_RS05630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4W23_RS05645	COG2706	6-phosphogluconolactonase activity
H4W23_RS05660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H4W23_RS05675	COG0598	Magnesium transport protein CorA
H4W23_RS05715	COG4566	intracellular signal transduction
H4W23_RS05720	COG5564	TIM-barrel signal transduction protein
H4W23_RS05730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS05735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W23_RS05755	COG2124	cytochrome p450
H4W23_RS05810	COG0577	efflux transmembrane transporter activity
H4W23_RS05810	COG1136	(ABC) transporter
H4W23_RS05815	COG4585	Histidine kinase
H4W23_RS05820	COG2197	response regulator
H4W23_RS05830	COG2311	Membrane
H4W23_RS05845	COG0006	proline dipeptidase activity
H4W23_RS05855	COG1505	serine-type exopeptidase activity
H4W23_RS05860	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H4W23_RS05875	COG1120	ATPase activity
H4W23_RS05880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS05885	COG2072	flavoprotein involved in K transport
H4W23_RS05895	COG1132	(ABC) transporter
H4W23_RS05920	COG1132	(ABC) transporter
H4W23_RS05925	COG1132	(ABC) transporter
H4W23_RS05930	COG2910	NAD(P)H-binding
H4W23_RS05950	COG1946	Acyl-CoA thioesterase
H4W23_RS05965	COG0386	Belongs to the glutathione peroxidase family
H4W23_RS05980	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS05990	COG0242	peptide deformylase activity
H4W23_RS06000	COG3442	glutamine amidotransferase
H4W23_RS06005	COG0205	6-phosphofructokinase activity
H4W23_RS06025	COG0204	Acyl-transferase
H4W23_RS06030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4W23_RS06040	COG0829	nickel cation binding
H4W23_RS06045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H4W23_RS06050	COG0830	nickel cation binding
H4W23_RS06055	COG0804	urea catabolic process
H4W23_RS06065	COG0831	urea catabolic process
H4W23_RS06070	COG1309	transcriptional regulator
H4W23_RS06085	COG0740	serine-type endopeptidase activity
H4W23_RS06110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4W23_RS06115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4W23_RS06120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4W23_RS06160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4W23_RS06165	COG3663	DNA glycosylase
H4W23_RS06180	COG1940	carbohydrate kinase activity
H4W23_RS06185	COG2188	Transcriptional regulator
H4W23_RS06190	COG1595	DNA-templated transcription, initiation
H4W23_RS06215	COG2268	Band 7 protein
H4W23_RS06220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS06245	COG0626	cystathionine gamma-synthase activity
H4W23_RS06250	COG1522	sequence-specific DNA binding
H4W23_RS06260	COG1522	sequence-specific DNA binding
H4W23_RS06265	COG0419	ATPase involved in DNA repair
H4W23_RS06270	COG0420	3'-5' exonuclease activity
H4W23_RS06275	COG1739	Uncharacterized protein family UPF0029
H4W23_RS06285	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS06295	COG4249	Peptidase C14 caspase catalytic subunit p20
H4W23_RS06295	COG2319	Wd-40 repeat
H4W23_RS06305	COG1832	CoA-binding protein
H4W23_RS06315	COG1396	sequence-specific DNA binding
H4W23_RS06325	COG0110	maltose O-acetyltransferase activity
H4W23_RS06330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4W23_RS06340	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W23_RS06360	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4W23_RS06375	COG0183	Belongs to the thiolase family
H4W23_RS06385	COG1968	undecaprenyl-diphosphatase activity
H4W23_RS06405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4W23_RS06415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H4W23_RS06435	COG2318	DinB family
H4W23_RS06450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4W23_RS06480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS06515	COG0531	amino acid
H4W23_RS06535	COG1175	transmembrane transport
H4W23_RS06545	COG1609	Transcriptional regulator
H4W23_RS06555	COG1501	Belongs to the glycosyl hydrolase 31 family
H4W23_RS06560	COG2814	Major facilitator Superfamily
H4W23_RS06570	COG0656	L-ascorbic acid biosynthetic process
H4W23_RS06700	COG1695	Transcriptional regulator
H4W23_RS06745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4W23_RS06745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4W23_RS06755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4W23_RS06775	COG1716	ATPase activity
H4W23_RS06795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4W23_RS06825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4W23_RS06840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS06855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4W23_RS06870	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H4W23_RS06880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS06895	COG2018	Roadblock/LC7 domain
H4W23_RS06935	COG2814	Major facilitator Superfamily
H4W23_RS06940	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4W23_RS06945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4W23_RS06950	COG1984	allophanate hydrolase subunit 2
H4W23_RS06965	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS06970	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS07010	COG2270	Major facilitator Superfamily
H4W23_RS07020	COG3030	protein affecting phage T7 exclusion by the F plasmid
H4W23_RS07025	COG1216	Glycosyl transferase, family 2
H4W23_RS07060	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS07100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4W23_RS07105	COG0140	phosphoribosyl-ATP diphosphatase activity
H4W23_RS07110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4W23_RS07115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4W23_RS07115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4W23_RS07120	COG3201	nicotinamide mononucleotide transporter
H4W23_RS07155	COG1846	Transcriptional regulator
H4W23_RS07155	COG1940	carbohydrate kinase activity
H4W23_RS07165	COG2233	PERMEase
H4W23_RS07180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4W23_RS07195	COG0531	amino acid
H4W23_RS07225	COG2390	Transcriptional regulator
H4W23_RS07230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4W23_RS07240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4W23_RS07255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4W23_RS07280	COG0284	orotidine-5'-phosphate decarboxylase activity
H4W23_RS07285	COG0167	dihydroorotate dehydrogenase activity
H4W23_RS07290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4W23_RS07295	COG0505	Belongs to the CarA family
H4W23_RS07305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4W23_RS07310	COG0540	Belongs to the ATCase OTCase family
H4W23_RS07315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H4W23_RS07325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4W23_RS07330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4W23_RS07335	COG0006	proline dipeptidase activity
H4W23_RS07345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4W23_RS07350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H4W23_RS07355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4W23_RS07360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4W23_RS07370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4W23_RS07375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4W23_RS07380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4W23_RS07385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4W23_RS07405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4W23_RS07420	COG0124	histidyl-tRNA synthetase
H4W23_RS07435	COG1196	nuclear chromosome segregation
H4W23_RS07440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4W23_RS07450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4W23_RS07455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4W23_RS07465	COG2255	four-way junction helicase activity
H4W23_RS07470	COG0632	four-way junction helicase activity
H4W23_RS07475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4W23_RS07480	COG0217	transcriptional regulatory protein
H4W23_RS07485	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H4W23_RS07490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H4W23_RS07505	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS07510	COG1560	Kdo2-lipid A biosynthetic process
H4W23_RS07515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4W23_RS07535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4W23_RS07540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4W23_RS07555	COG2176	DNA-directed DNA polymerase activity
H4W23_RS07555	COG5002	protein histidine kinase activity
H4W23_RS07605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4W23_RS07605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4W23_RS07610	COG0456	acetyltransferase
H4W23_RS07610	COG0454	-acetyltransferase
H4W23_RS07615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4W23_RS07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4W23_RS07680	COG1648	precorrin-2 dehydrogenase activity
H4W23_RS07680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4W23_RS07685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4W23_RS07700	COG1464	Belongs to the NlpA lipoprotein family
H4W23_RS07705	COG2011	ABC-type metal ion transport system permease component
H4W23_RS07735	COG0584	glycerophosphoryl diester phosphodiesterase
H4W23_RS07740	COG0204	Acyl-transferase
H4W23_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS07745	COG0477	Major facilitator Superfamily
H4W23_RS07755	COG0165	Argininosuccinate lyase
H4W23_RS07770	COG1438	arginine binding
H4W23_RS07775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4W23_RS07780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4W23_RS07785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4W23_RS07790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4W23_RS07800	COG0488	(ABC) transporter
H4W23_RS07810	COG2813	Specifically methylates the guanine in position
H4W23_RS07830	COG0697	spore germination
H4W23_RS07840	COG1649	PFAM Uncharacterised BCR, COG1649
H4W23_RS07850	COG1051	belongs to the nudix hydrolase family
H4W23_RS07875	COG0072	phenylalanine-tRNA ligase activity
H4W23_RS07875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W23_RS07880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4W23_RS07885	COG5002	protein histidine kinase activity
H4W23_RS07890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4W23_RS07895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4W23_RS07900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H4W23_RS07905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4W23_RS07945	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS07950	COG0174	glutamine synthetase
H4W23_RS07960	COG1113	amino acid transport
H4W23_RS07965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4W23_RS08015	COG0517	IMP dehydrogenase activity
H4W23_RS08015	COG4175	Glycine betaine
H4W23_RS08020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4W23_RS08045	COG2226	methyltransferase
H4W23_RS08050	COG2124	cytochrome p450
H4W23_RS08060	COG0805	protein transport
H4W23_RS08065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4W23_RS08100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H4W23_RS08110	COG1609	Transcriptional regulator
H4W23_RS08115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H4W23_RS08120	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H4W23_RS08130	COG4122	O-methyltransferase activity
H4W23_RS08135	COG1222	aaa ATPase
H4W23_RS08155	COG0517	IMP dehydrogenase activity
H4W23_RS08155	COG1994	Peptidase M50
H4W23_RS08165	COG2197	response regulator
H4W23_RS08175	COG0747	negative chemotaxis
H4W23_RS08185	COG0646	methionine synthase
H4W23_RS08185	COG1410	methionine synthase
H4W23_RS08190	COG1414	Transcriptional regulator
H4W23_RS08195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4W23_RS08200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4W23_RS08205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4W23_RS08210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS08225	COG0215	cysteine-tRNA ligase activity
H4W23_RS08245	COG0598	Magnesium transport protein CorA
H4W23_RS08255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS08260	COG0667	Aldo Keto reductase
H4W23_RS08290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4W23_RS08300	COG0564	pseudouridine synthase activity
H4W23_RS08315	COG1113	amino acid transport
H4W23_RS08320	COG2186	Transcriptional regulator
H4W23_RS08325	COG3265	gluconokinase activity
H4W23_RS08335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS08355	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H4W23_RS08360	COG2149	membrane
H4W23_RS08380	COG4948	Mandelate Racemase Muconate Lactonizing
H4W23_RS08390	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS08405	COG3876	Protein conserved in bacteria
H4W23_RS08450	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS08460	COG0640	Transcriptional regulator
H4W23_RS08515	COG2851	Citrate transporter
H4W23_RS08520	COG0243	molybdopterin cofactor binding
H4W23_RS08525	COG1309	transcriptional regulator
H4W23_RS08555	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H4W23_RS08560	COG2188	Transcriptional regulator
H4W23_RS08590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W23_RS08600	COG0515	serine threonine protein kinase
H4W23_RS08605	COG2755	lipolytic protein G-D-S-L family
H4W23_RS08620	COG0726	polysaccharide deacetylase
H4W23_RS08630	COG1725	Transcriptional regulator
H4W23_RS08670	COG4565	transcriptional regulatory protein
H4W23_RS08705	COG0587	DNA-directed DNA polymerase activity
H4W23_RS08720	COG1454	alcohol dehydrogenase
H4W23_RS08720	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS08735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS08740	COG1126	abc transporter atp-binding protein
H4W23_RS08755	COG0765	amino acid transport
H4W23_RS08775	COG1799	cell septum assembly
H4W23_RS08780	COG0477	Major facilitator Superfamily
H4W23_RS08785	COG0671	phosphoesterase, PA-phosphatase related
H4W23_RS08795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4W23_RS08805	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS08825	COG0411	ABC transporter
H4W23_RS08835	COG3583	domain protein
H4W23_RS08850	COG1160	GTP binding
H4W23_RS08860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4W23_RS08895	COG1397	ADP-ribosylglycohydrolase
H4W23_RS08915	COG1187	pseudouridine synthase activity
H4W23_RS08920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4W23_RS08925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4W23_RS08940	COG0686	Belongs to the AlaDH PNT family
H4W23_RS08950	COG0494	nUDIX hydrolase
H4W23_RS08955	COG0504	CTP synthase activity
H4W23_RS08960	COG3387	PFAM Glycoside hydrolase 15-related
H4W23_RS08985	COG0297	glycogen (starch) synthase activity
H4W23_RS08995	COG0497	DNA recombination
H4W23_RS09000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4W23_RS09020	COG1120	ATPase activity
H4W23_RS09025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS09030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS09035	COG0647	UMP catabolic process
H4W23_RS09065	COG2094	Belongs to the DNA glycosylase MPG family
H4W23_RS09075	COG1881	PFAM PEBP family protein
H4W23_RS09100	COG1119	ATPase activity
H4W23_RS09115	COG2197	response regulator
H4W23_RS09120	COG4585	Histidine kinase
H4W23_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS09135	COG1131	(ABC) transporter
H4W23_RS09135	COG0842	Transport permease protein
H4W23_RS09135	COG1716	ATPase activity
H4W23_RS09140	COG0560	Phosphoserine phosphatase
H4W23_RS09140	COG3830	Belongs to the UPF0237 family
H4W23_RS09160	COG2186	Transcriptional regulator
H4W23_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS09190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4W23_RS09210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4W23_RS09215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4W23_RS09230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W23_RS09280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4W23_RS09295	COG3387	PFAM Glycoside hydrolase 15-related
H4W23_RS09335	COG1024	Enoyl-CoA hydratase
H4W23_RS09345	COG0488	(ABC) transporter
H4W23_RS09380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4W23_RS09385	COG1492	cobalamin metabolic process
H4W23_RS09400	COG1797	cobyrinic acid a,c-diamide synthase activity
H4W23_RS09445	COG1104	cysteine desulfurase activity
H4W23_RS09450	COG1902	pentaerythritol trinitrate reductase activity
H4W23_RS09485	COG2207	Transcriptional regulator
H4W23_RS09490	COG0604	alcohol dehydrogenase
H4W23_RS09490	COG3321	synthase
H4W23_RS09515	COG4585	Histidine kinase
H4W23_RS09520	COG2197	response regulator
H4W23_RS09525	COG0768	penicillin binding
H4W23_RS09545	COG3290	protein histidine kinase activity
H4W23_RS09550	COG0402	S-adenosylhomocysteine deaminase activity
H4W23_RS09570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4W23_RS09575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4W23_RS09635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4W23_RS09645	COG2171	N-acyltransferase activity
H4W23_RS09650	COG1309	transcriptional regulator
H4W23_RS09660	COG3226	Transcriptional regulator
H4W23_RS09665	COG2076	Multidrug Resistance protein
H4W23_RS09675	COG2151	metal-sulfur cluster biosynthetic enzyme
H4W23_RS09680	COG0822	iron-sulfur transferase activity
H4W23_RS09685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4W23_RS09690	COG0396	ATPase activity
H4W23_RS09700	COG0719	Fe-S assembly protein
H4W23_RS09725	COG1612	heme a metabolic process
H4W23_RS09745	COG0109	protoheme IX farnesyltransferase activity
H4W23_RS09755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4W23_RS09770	COG0363	glucosamine-6-phosphate deaminase activity
H4W23_RS09785	COG0166	Belongs to the GPI family
H4W23_RS09800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4W23_RS09805	COG0149	triose-phosphate isomerase activity
H4W23_RS09810	COG0126	phosphoglycerate kinase activity
H4W23_RS09815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4W23_RS09825	COG1481	regulation of sporulation
H4W23_RS09830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H4W23_RS09835	COG1660	Displays ATPase and GTPase activities
H4W23_RS09840	COG0322	excinuclease ABC activity
H4W23_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS09870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4W23_RS09885	COG0477	Major facilitator Superfamily
H4W23_RS09905	COG0556	nucleotide-excision repair
H4W23_RS09915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4W23_RS09945	COG2313	pseudouridylate synthase activity
H4W23_RS09975	COG1733	regulation of RNA biosynthetic process
H4W23_RS10005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4W23_RS10025	COG0237	dephospho-CoA kinase activity
H4W23_RS10040	COG2226	methyltransferase
H4W23_RS10045	COG1643	Atp-dependent helicase
H4W23_RS10080	COG2050	protein possibly involved in aromatic compounds catabolism
H4W23_RS10100	COG0411	ABC transporter
H4W23_RS10130	COG0737	Belongs to the 5'-nucleotidase family
H4W23_RS10150	COG0252	asparaginase activity
H4W23_RS10155	COG1605	Chorismate mutase
H4W23_RS10155	COG0287	Prephenate dehydrogenase
H4W23_RS10190	COG0513	Belongs to the DEAD box helicase family
H4W23_RS10195	COG1309	transcriptional regulator
H4W23_RS10210	COG0667	Aldo Keto reductase
H4W23_RS10225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS10235	COG0069	glutamate synthase activity
H4W23_RS10235	COG0067	glutamate synthase
H4W23_RS10235	COG0070	glutamate synthase
H4W23_RS10265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W23_RS10270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W23_RS10280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4W23_RS10290	COG0159	tryptophan synthase activity
H4W23_RS10295	COG0133	tryptophan synthase activity
H4W23_RS10305	COG0134	indole-3-glycerol-phosphate synthase activity
H4W23_RS10330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4W23_RS10350	COG0107	imidazoleglycerol-phosphate synthase activity
H4W23_RS10355	COG0251	oxidation-reduction process
H4W23_RS10360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4W23_RS10365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4W23_RS10375	COG0131	Imidazoleglycerol-phosphate dehydratase
H4W23_RS10380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4W23_RS10385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4W23_RS10405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4W23_RS10425	COG1432	Conserved Protein
H4W23_RS10435	COG0587	DNA-directed DNA polymerase activity
H4W23_RS10485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4W23_RS10495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H4W23_RS10510	COG1799	cell septum assembly
H4W23_RS10515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4W23_RS10520	COG1496	oxidoreductase activity
H4W23_RS10530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4W23_RS10535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4W23_RS10545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4W23_RS10550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4W23_RS10560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4W23_RS10575	COG0275	rRNA processing
H4W23_RS10585	COG0714	Associated with various cellular activities
H4W23_RS10605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4W23_RS10615	COG1132	(ABC) transporter
H4W23_RS10620	COG1511	domain protein
H4W23_RS10625	COG1309	transcriptional regulator
H4W23_RS10650	COG0352	thiamine-phosphate diphosphorylase activity
H4W23_RS10665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W23_RS10665	COG2022	thiamine diphosphate biosynthetic process
H4W23_RS10675	COG2022	thiamine diphosphate biosynthetic process
H4W23_RS10680	COG0515	serine threonine protein kinase
H4W23_RS10680	COG2815	serine threonine protein kinase
H4W23_RS10685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H4W23_RS10695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4W23_RS10700	COG2193	ferroxidase activity
H4W23_RS10705	COG0243	molybdopterin cofactor binding
H4W23_RS10710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4W23_RS10730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4W23_RS10740	COG4585	Histidine kinase
H4W23_RS10765	COG1940	carbohydrate kinase activity
H4W23_RS10775	COG0003	Pfam Anion-transporting ATPase
H4W23_RS10790	COG1022	Amp-dependent synthetase and ligase
H4W23_RS10805	COG0534	Mate efflux family protein
H4W23_RS10820	COG0791	NLP P60 protein
H4W23_RS10840	COG0705	Rhomboid family
H4W23_RS10850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4W23_RS10855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4W23_RS10860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4W23_RS10865	COG0723	plastoquinol--plastocyanin reductase activity
H4W23_RS10870	COG2010	Cytochrome c
H4W23_RS10875	COG1845	cytochrome c oxidase, subunit III
H4W23_RS10885	COG1376	ErfK ybiS ycfS ynhG family protein
H4W23_RS10895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4W23_RS10900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4W23_RS10910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W23_RS10930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4W23_RS10935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4W23_RS10940	COG2197	response regulator
H4W23_RS10945	COG4585	Histidine kinase
H4W23_RS10965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4W23_RS10980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4W23_RS10985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4W23_RS10985	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H4W23_RS11030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4W23_RS11035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4W23_RS11040	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS11050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H4W23_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS11100	COG0321	lipoyl(octanoyl) transferase activity
H4W23_RS11105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4W23_RS11150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS11155	COG0673	inositol 2-dehydrogenase activity
H4W23_RS11180	COG0745	RESPONSE REGULATOR receiver
H4W23_RS11200	COG2365	Tyrosine phosphatase family
H4W23_RS11225	COG1309	transcriptional regulator
H4W23_RS11255	COG0366	Alpha amylase catalytic
H4W23_RS11260	COG0395	ABC-type sugar transport system, permease component
H4W23_RS11265	COG1175	transmembrane transport
H4W23_RS11270	COG2182	Extracellular solute-binding protein
H4W23_RS11275	COG1609	Transcriptional regulator
H4W23_RS11285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4W23_RS11320	COG0174	glutamine synthetase
H4W23_RS11345	COG2267	carboxylic ester hydrolase activity
H4W23_RS11355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4W23_RS11355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4W23_RS11360	COG2814	Major facilitator Superfamily
H4W23_RS11370	COG1309	transcriptional regulator
H4W23_RS11375	COG0477	Major facilitator Superfamily
H4W23_RS11380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H4W23_RS11400	COG1994	Peptidase M50
H4W23_RS11455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4W23_RS11460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS11465	COG1120	ATPase activity
H4W23_RS11475	COG2837	iron assimilation
H4W23_RS11480	COG0672	)-iron permease
H4W23_RS11495	COG1834	amidinotransferase
H4W23_RS11510	COG2814	Major facilitator Superfamily
H4W23_RS11540	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS11545	COG0022	dehydrogenase e1 component
H4W23_RS11585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS11590	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H4W23_RS11605	COG0604	alcohol dehydrogenase
H4W23_RS11605	COG3321	synthase
H4W23_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS11630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS11660	COG4585	Histidine kinase
H4W23_RS11675	COG2197	response regulator
H4W23_RS11700	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS11710	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H4W23_RS11750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4W23_RS11755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4W23_RS11760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS11765	COG0477	Major facilitator Superfamily
H4W23_RS11770	COG2409	Drug exporters of the RND superfamily
H4W23_RS11800	COG3022	response to hydroperoxide
H4W23_RS11805	COG0800	Aldolase
H4W23_RS11825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4W23_RS11830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4W23_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS11850	COG2030	dehydratase
H4W23_RS11855	COG1131	(ABC) transporter
H4W23_RS11865	COG4585	Histidine kinase
H4W23_RS11880	COG2197	response regulator
H4W23_RS11885	COG4585	Histidine kinase
H4W23_RS11925	COG2197	response regulator
H4W23_RS11940	COG0183	Belongs to the thiolase family
H4W23_RS11945	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS12015	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4W23_RS12025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS12050	COG1309	transcriptional regulator
H4W23_RS12095	COG3845	ABC transporter
H4W23_RS12115	COG0183	Belongs to the thiolase family
H4W23_RS12120	COG2124	cytochrome p450
H4W23_RS12130	COG4122	O-methyltransferase activity
H4W23_RS12200	COG2188	Transcriptional regulator
H4W23_RS12250	COG1358	cellular component organization or biogenesis
H4W23_RS12295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H4W23_RS12300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4W23_RS12310	COG0477	Major facilitator Superfamily
H4W23_RS12315	COG1309	transcriptional regulator
H4W23_RS12330	COG4585	Histidine kinase
H4W23_RS12335	COG2197	response regulator
H4W23_RS12350	COG0667	Aldo Keto reductase
H4W23_RS12355	COG0789	Transcriptional regulator
H4W23_RS12370	COG2205	protein histidine kinase activity
H4W23_RS12375	COG0745	RESPONSE REGULATOR receiver
H4W23_RS12390	COG1376	ErfK ybiS ycfS ynhG family protein
H4W23_RS12395	COG1741	Belongs to the pirin family
H4W23_RS12410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS12415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4W23_RS12420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4W23_RS12445	COG1309	transcriptional regulator
H4W23_RS12450	COG2084	Dehydrogenase
H4W23_RS12455	COG0583	DNA-binding transcription factor activity
H4W23_RS12485	COG1764	response to oxidative stress
H4W23_RS12490	COG2130	NADP-dependent
H4W23_RS12505	COG1077	Cell shape determining protein MreB Mrl
H4W23_RS12520	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS12550	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4W23_RS12555	COG0477	Major facilitator Superfamily
H4W23_RS12560	COG1846	Transcriptional regulator
H4W23_RS12565	COG1764	response to oxidative stress
H4W23_RS12585	COG0475	glutathione-regulated potassium exporter activity
H4W23_RS12610	COG3511	phospholipase C
H4W23_RS12650	COG3118	belongs to the thioredoxin family
H4W23_RS12655	COG0492	ferredoxin-NADP+ reductase activity
H4W23_RS12660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4W23_RS12670	COG0798	PFAM Bile acid sodium symporter
H4W23_RS12685	COG0640	Transcriptional regulator
H4W23_RS12690	COG3634	alkyl hydroperoxide reductase activity
H4W23_RS12750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4W23_RS12800	COG0789	Transcriptional regulator
H4W23_RS12830	COG1228	amidohydrolase
H4W23_RS12870	COG1484	DNA-dependent DNA replication
H4W23_RS12900	COG0739	heme binding
H4W23_RS12900	COG0741	lytic transglycosylase activity
H4W23_RS12900	COG1196	nuclear chromosome segregation
H4W23_RS12980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4W23_RS13015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4W23_RS13030	COG0745	RESPONSE REGULATOR receiver
H4W23_RS13035	COG2205	protein histidine kinase activity
H4W23_RS13040	COG2409	Drug exporters of the RND superfamily
H4W23_RS13055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4W23_RS13065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4W23_RS13070	COG0300	oxidoreductase activity
H4W23_RS13080	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H4W23_RS13095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4W23_RS13125	COG0789	Transcriptional regulator
H4W23_RS13130	COG0659	secondary active sulfate transmembrane transporter activity
H4W23_RS13140	COG2259	Doxx family
H4W23_RS13145	COG1695	Transcriptional regulator
H4W23_RS13280	COG0582	viral genome integration into host DNA
H4W23_RS13305	COG1070	Carbohydrate kinase
H4W23_RS13325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4W23_RS13330	COG0358	DNA primase activity
H4W23_RS13340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H4W23_RS13360	COG2949	membrane
H4W23_RS13365	COG0243	molybdopterin cofactor binding
H4W23_RS13430	COG1017	nitric oxide dioxygenase activity
H4W23_RS13430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4W23_RS13435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4W23_RS13440	COG2146	nitrite reductase [NAD(P)H] activity
H4W23_RS13440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4W23_RS13445	COG2146	nitrite reductase [NAD(P)H] activity
H4W23_RS13445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4W23_RS13450	COG1309	transcriptional regulator
H4W23_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS13490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4W23_RS13490	COG0574	Belongs to the PEP-utilizing enzyme family
H4W23_RS13500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4W23_RS13525	COG0477	Major facilitator Superfamily
H4W23_RS13535	COG0667	Aldo Keto reductase
H4W23_RS13560	COG0423	glycine-tRNA ligase activity
H4W23_RS13565	COG3443	Belongs to the bacterial solute-binding protein 9 family
H4W23_RS13565	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4W23_RS13570	COG1121	(ABC) transporter
H4W23_RS13575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4W23_RS13590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4W23_RS13595	COG1381	Involved in DNA repair and RecF pathway recombination
H4W23_RS13675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4W23_RS13695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4W23_RS13730	COG2315	Protein conserved in bacteria
H4W23_RS13740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4W23_RS13750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W23_RS13760	COG2226	methyltransferase
H4W23_RS13765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4W23_RS13770	COG1234	tRNA 3'-trailer cleavage
H4W23_RS13775	COG0537	adenosine 5'-monophosphoramidase activity
H4W23_RS13785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4W23_RS13800	COG2070	2-Nitropropane dioxygenase
H4W23_RS13805	COG0484	heat shock protein binding
H4W23_RS13810	COG1420	regulation of RNA biosynthetic process
H4W23_RS13835	COG0481	GTPase activity
H4W23_RS13840	COG0268	Binds directly to 16S ribosomal RNA
H4W23_RS13855	COG2353	YceI-like domain
H4W23_RS13860	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H4W23_RS13885	COG1307	EDD domain protein, DegV family
H4W23_RS13895	COG0495	leucyl-tRNA aminoacylation
H4W23_RS13915	COG0477	Major facilitator Superfamily
H4W23_RS13930	COG0588	phosphoglycerate mutase activity
H4W23_RS13935	COG0799	negative regulation of ribosome biogenesis
H4W23_RS13945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4W23_RS13960	COG0501	Belongs to the peptidase M48B family
H4W23_RS13975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4W23_RS13985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H4W23_RS13995	COG0463	Glycosyl transferase, family 2
H4W23_RS14010	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS14015	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H4W23_RS14020	COG1216	Glycosyl transferase, family 2
H4W23_RS14025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4W23_RS14030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4W23_RS14035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4W23_RS14040	COG1530	ribonuclease E activity
H4W23_RS14060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H4W23_RS14065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H4W23_RS14080	COG0772	Belongs to the SEDS family
H4W23_RS14085	COG0768	penicillin binding
H4W23_RS14100	COG1077	Cell shape determining protein MreB Mrl
H4W23_RS14105	COG0105	UTP biosynthetic process
H4W23_RS14115	COG0285	dihydrofolate synthase activity
H4W23_RS14120	COG1077	Cell shape determining protein MreB Mrl
H4W23_RS14150	COG0525	valine-tRNA ligase activity
H4W23_RS14160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4W23_RS14165	COG0740	serine-type endopeptidase activity
H4W23_RS14170	COG0740	serine-type endopeptidase activity
H4W23_RS14175	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4W23_RS14205	COG4552	Acetyltransferase involved in intracellular survival and related
H4W23_RS14220	COG1113	amino acid transport
H4W23_RS14230	COG1113	amino acid transport
H4W23_RS14235	COG1113	amino acid transport
H4W23_RS14240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4W23_RS14245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4W23_RS14280	COG0346	lactoylglutathione lyase activity
H4W23_RS14310	COG4266	Belongs to the allantoicase family
H4W23_RS14325	COG0697	spore germination
H4W23_RS14330	COG1846	Transcriptional regulator
H4W23_RS14350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4W23_RS14350	COG3291	Pkd domain containing protein
H4W23_RS14360	COG0668	transmembrane transport
H4W23_RS14370	COG1653	transport
H4W23_RS14375	COG1175	transmembrane transport
H4W23_RS14380	COG0395	ABC-type sugar transport system, permease component
H4W23_RS14385	COG1486	melibiose metabolic process
H4W23_RS14400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS14430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4W23_RS14435	COG2346	COG2346, Truncated hemoglobins
H4W23_RS14450	COG1136	(ABC) transporter
H4W23_RS14450	COG0577	efflux transmembrane transporter activity
H4W23_RS14485	COG0629	single-stranded DNA binding
H4W23_RS14490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4W23_RS14505	COG2050	protein possibly involved in aromatic compounds catabolism
H4W23_RS14515	COG1522	sequence-specific DNA binding
H4W23_RS14550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4W23_RS14555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4W23_RS14615	COG3962	Belongs to the TPP enzyme family
H4W23_RS14620	COG3718	enzyme involved in inositol metabolism
H4W23_RS14640	COG2409	Drug exporters of the RND superfamily
H4W23_RS14650	COG0475	glutathione-regulated potassium exporter activity
H4W23_RS14650	COG0569	domain protein
H4W23_RS14670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4W23_RS14700	COG0673	inositol 2-dehydrogenase activity
H4W23_RS14705	COG1609	Transcriptional regulator
H4W23_RS14715	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W23_RS14780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H4W23_RS14820	COG1946	Acyl-CoA thioesterase
H4W23_RS14835	COG1309	transcriptional regulator
H4W23_RS14840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4W23_RS14855	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS14870	COG0076	glutamate decarboxylase activity
H4W23_RS14875	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H4W23_RS14910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W23_RS14920	COG0589	response to stress
H4W23_RS14930	COG4977	sequence-specific DNA binding
H4W23_RS14935	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4W23_RS14960	COG1175	transmembrane transport
H4W23_RS14980	COG3469	chitinase activity
H4W23_RS14990	COG0745	RESPONSE REGULATOR receiver
H4W23_RS15015	COG0406	alpha-ribazole phosphatase activity
H4W23_RS15075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS15100	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS15105	COG3397	chitin binding
H4W23_RS15180	COG2188	Transcriptional regulator
H4W23_RS15190	COG1940	carbohydrate kinase activity
H4W23_RS15195	COG0673	inositol 2-dehydrogenase activity
H4W23_RS15200	COG4702	Belongs to the UPF0303 family
H4W23_RS15210	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4W23_RS15215	COG0706	membrane insertase activity
H4W23_RS15235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4W23_RS15245	COG3764	Sortase (surface protein transpeptidase)
H4W23_RS15295	COG1074	ATP-dependent DNA helicase activity
H4W23_RS15315	COG2733	membrane
H4W23_RS15320	COG4555	ABC transporter
H4W23_RS15335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4W23_RS15375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4W23_RS15385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4W23_RS15390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4W23_RS15395	COG1263	PTS System
H4W23_RS15400	COG1263	PTS System
H4W23_RS15410	COG3271	cysteine-type peptidase activity
H4W23_RS15410	COG2274	protein secretion by the type I secretion system
H4W23_RS15420	COG1234	tRNA 3'-trailer cleavage
H4W23_RS15440	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4W23_RS15445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS15460	COG1113	amino acid transport
H4W23_RS15470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H4W23_RS15480	COG1335	isochorismatase
H4W23_RS15515	COG0277	FAD linked oxidase domain protein
H4W23_RS15525	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H4W23_RS15575	COG3654	unkown
H4W23_RS15675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4W23_RS15690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4W23_RS15695	COG0395	ABC-type sugar transport system, permease component
H4W23_RS15715	COG1678	Uncharacterized ACR, COG1678
H4W23_RS15720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4W23_RS15725	COG0776	regulation of translation
H4W23_RS15735	COG3973	AAA domain
H4W23_RS15735	COG3973	AAA domain
H4W23_RS15755	COG0583	DNA-binding transcription factor activity
H4W23_RS15770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4W23_RS15775	COG0793	Belongs to the peptidase S41A family
H4W23_RS15785	COG2884	Cell division ATP-binding protein ftsE
H4W23_RS15800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4W23_RS15805	COG0515	serine threonine protein kinase
H4W23_RS15810	COG0515	serine threonine protein kinase
H4W23_RS15820	COG1653	transport
H4W23_RS15825	COG1175	transmembrane transport
H4W23_RS15830	COG0395	ABC-type sugar transport system, permease component
H4W23_RS15835	COG1309	transcriptional regulator
H4W23_RS15855	COG2902	Dehydrogenase
H4W23_RS15880	COG0653	protein targeting
H4W23_RS15890	COG3214	Protein conserved in bacteria
H4W23_RS15895	COG2197	response regulator
H4W23_RS15900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4W23_RS15910	COG0823	Involved in the tonB-independent uptake of proteins
H4W23_RS15915	COG5000	phosphorelay sensor kinase activity
H4W23_RS15915	COG5002	protein histidine kinase activity
H4W23_RS15920	COG0745	RESPONSE REGULATOR receiver
H4W23_RS15940	COG0714	Associated with various cellular activities
H4W23_RS15980	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4W23_RS15990	COG1482	cell wall glycoprotein biosynthetic process
H4W23_RS16000	COG2835	tetraacyldisaccharide 4'-kinase activity
H4W23_RS16040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H4W23_RS16045	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H4W23_RS16045	COG0778	Nitroreductase
H4W23_RS16100	COG1316	TRANSCRIPTIONal
H4W23_RS16110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4W23_RS16170	COG2205	protein histidine kinase activity
H4W23_RS16175	COG0745	RESPONSE REGULATOR receiver
H4W23_RS16180	COG3104	oligopeptide transport
H4W23_RS16215	COG1191	sigma factor activity
H4W23_RS16220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4W23_RS16270	COG1228	amidohydrolase
H4W23_RS16285	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4W23_RS16335	COG0183	Belongs to the thiolase family
H4W23_RS16350	COG0596	Alpha beta hydrolase
H4W23_RS16370	COG1136	(ABC) transporter
H4W23_RS16375	COG1136	(ABC) transporter
H4W23_RS16375	COG0577	efflux transmembrane transporter activity
H4W23_RS16380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4W23_RS16385	COG1252	NADH dehydrogenase
H4W23_RS16405	COG0148	phosphopyruvate hydratase activity
H4W23_RS16420	COG2124	cytochrome p450
H4W23_RS16445	COG0463	Glycosyl transferase, family 2
H4W23_RS16495	COG2815	serine threonine protein kinase
H4W23_RS16495	COG0515	serine threonine protein kinase
H4W23_RS16560	COG0577	efflux transmembrane transporter activity
H4W23_RS16565	COG1136	(ABC) transporter
H4W23_RS16570	COG0477	Major facilitator Superfamily
H4W23_RS16635	COG4585	Histidine kinase
H4W23_RS16645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4W23_RS16650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4W23_RS16660	COG0583	DNA-binding transcription factor activity
H4W23_RS16665	COG0768	penicillin binding
H4W23_RS16670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H4W23_RS16675	COG0193	aminoacyl-tRNA hydrolase activity
H4W23_RS16690	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H4W23_RS16700	COG1309	transcriptional regulator
H4W23_RS16715	COG4106	trans-aconitate 2-methyltransferase activity
H4W23_RS16720	COG1846	Transcriptional regulator
H4W23_RS16725	COG2197	response regulator
H4W23_RS16730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H4W23_RS16760	COG0488	(ABC) transporter
H4W23_RS16790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H4W23_RS16795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4W23_RS16800	COG1388	LysM domain
H4W23_RS16805	COG0084	hydrolase, TatD family'
H4W23_RS16840	COG0442	prolyl-tRNA aminoacylation
H4W23_RS16860	COG1595	DNA-templated transcription, initiation
H4W23_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS16880	COG1280	lysine exporter protein (LysE YggA)
H4W23_RS16885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4W23_RS16895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W23_RS16900	COG1122	ATPase activity
H4W23_RS16910	COG0310	cobalt ion transport
H4W23_RS16920	COG2409	Drug exporters of the RND superfamily
H4W23_RS16930	COG4946	Tricorn protease homolog
H4W23_RS16930	COG0793	Belongs to the peptidase S41A family
H4W23_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS16955	COG2267	carboxylic ester hydrolase activity
H4W23_RS16960	COG2072	flavoprotein involved in K transport
H4W23_RS16970	COG0708	Exodeoxyribonuclease III
H4W23_RS16995	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4W23_RS17000	COG0315	cyclic pyranopterin monophosphate synthase activity
H4W23_RS17010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4W23_RS17015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4W23_RS17025	COG3263	regulation of cellular component size
H4W23_RS17040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H4W23_RS17050	COG1970	mechanosensitive ion channel activity
H4W23_RS17070	COG0437	4 iron, 4 sulfur cluster binding
H4W23_RS17075	COG0243	molybdopterin cofactor binding
H4W23_RS17085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H4W23_RS17095	COG2223	nitrite transmembrane transporter activity
H4W23_RS17115	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS17120	COG3191	aminopeptidase activity
H4W23_RS17130	COG0477	Major facilitator Superfamily
H4W23_RS17150	COG3384	dioxygenase
H4W23_RS17155	COG1846	Transcriptional regulator
H4W23_RS17250	COG1131	(ABC) transporter
H4W23_RS17265	COG0584	glycerophosphoryl diester phosphodiesterase
H4W23_RS17340	COG1686	Belongs to the peptidase S11 family
H4W23_RS17380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H4W23_RS17495	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS17510	COG1024	Enoyl-CoA hydratase
H4W23_RS17525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS17525	COG0515	serine threonine protein kinase
H4W23_RS17535	COG1309	transcriptional regulator
H4W23_RS17560	COG0259	pyridoxamine-phosphate oxidase activity
H4W23_RS17570	COG1309	transcriptional regulator
H4W23_RS17590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H4W23_RS17600	COG0163	prenyltransferase activity
H4W23_RS17610	COG2255	four-way junction helicase activity
H4W23_RS17660	COG0463	Glycosyl transferase, family 2
H4W23_RS17670	COG0109	protoheme IX farnesyltransferase activity
H4W23_RS17675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H4W23_RS17685	COG0583	DNA-binding transcription factor activity
H4W23_RS17765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4W23_RS17770	COG1333	cytochrome c biogenesis protein
H4W23_RS17775	COG0785	Cytochrome C biogenesis protein
H4W23_RS17790	COG0406	alpha-ribazole phosphatase activity
H4W23_RS17795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4W23_RS17810	COG0531	amino acid
H4W23_RS17815	COG0789	Transcriptional regulator
H4W23_RS17860	COG1846	Transcriptional regulator
H4W23_RS17880	COG1690	Belongs to the RtcB family
H4W23_RS17900	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H4W23_RS17905	COG0018	arginyl-trna synthetase
H4W23_RS17920	COG0113	porphobilinogen synthase activity
H4W23_RS17925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4W23_RS17925	COG1648	precorrin-2 dehydrogenase activity
H4W23_RS17930	COG0181	hydroxymethylbilane synthase activity
H4W23_RS17935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H4W23_RS17940	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H4W23_RS17990	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4W23_RS17995	COG2223	nitrite transmembrane transporter activity
H4W23_RS18000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS18020	COG0180	Tryptophanyl-tRNA synthetase
H4W23_RS18035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4W23_RS18045	COG0842	Transport permease protein
H4W23_RS18045	COG1129	ABC transporter
H4W23_RS18060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS18060	COG0515	serine threonine protein kinase
H4W23_RS18065	COG0129	dihydroxy-acid dehydratase activity
H4W23_RS18075	COG1082	Xylose isomerase domain protein TIM barrel
H4W23_RS18080	COG0248	Ppx GppA phosphatase
H4W23_RS18100	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H4W23_RS18110	COG0671	phosphoesterase, PA-phosphatase related
H4W23_RS18115	COG1194	a g-specific adenine glycosylase
H4W23_RS18120	COG1595	DNA-templated transcription, initiation
H4W23_RS18130	COG0745	RESPONSE REGULATOR receiver
H4W23_RS18135	COG2205	protein histidine kinase activity
H4W23_RS18150	COG0739	heme binding
H4W23_RS18175	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H4W23_RS18195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4W23_RS18200	COG0157	Belongs to the NadC ModD family
H4W23_RS18205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4W23_RS18210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4W23_RS18220	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H4W23_RS18235	COG2197	response regulator
H4W23_RS18250	COG0649	NAD binding
H4W23_RS18265	COG1732	Glycine betaine
H4W23_RS18270	COG1174	glycine betaine transport
H4W23_RS18290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4W23_RS18290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H4W23_RS18305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4W23_RS18320	COG0302	gtp cyclohydrolase
H4W23_RS18335	COG0037	tRNA processing
H4W23_RS18345	COG2027	D-alanyl-D-alanine carboxypeptidase
H4W23_RS18350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4W23_RS18360	COG0586	Pfam SNARE associated Golgi protein
H4W23_RS18365	COG0393	Putative heavy-metal-binding
H4W23_RS18375	COG0076	glutamate decarboxylase activity
H4W23_RS18400	COG2318	DinB family
H4W23_RS18405	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS18430	COG0254	rRNA binding
H4W23_RS18435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H4W23_RS18440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4W23_RS18445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4W23_RS18455	COG1595	DNA-templated transcription, initiation
H4W23_RS18465	COG1289	transmembrane transporter activity
H4W23_RS18475	COG1136	(ABC) transporter
H4W23_RS18495	COG2197	response regulator
H4W23_RS18500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4W23_RS18500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4W23_RS18520	COG1595	DNA-templated transcription, initiation
H4W23_RS18555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4W23_RS18560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS18575	COG0736	holo-[acyl-carrier-protein] synthase activity
H4W23_RS18600	COG3903	Transcriptional regulator
H4W23_RS18600	COG3629	intracellular signal transduction
H4W23_RS18615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4W23_RS18630	COG2197	response regulator
H4W23_RS18645	COG1136	(ABC) transporter
H4W23_RS18645	COG0577	efflux transmembrane transporter activity
H4W23_RS18650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4W23_RS18655	COG1754	DNA topoisomerase type I activity
H4W23_RS18655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4W23_RS18675	COG1131	(ABC) transporter
H4W23_RS18685	COG2890	protein-(glutamine-N5) methyltransferase activity
H4W23_RS18695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H4W23_RS18705	COG1366	Belongs to the anti-sigma-factor antagonist family
H4W23_RS18710	COG1111	helicase
H4W23_RS18710	COG1205	dead DEAH box helicase
H4W23_RS18775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4W23_RS18780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4W23_RS18790	COG2267	carboxylic ester hydrolase activity
H4W23_RS18820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4W23_RS18845	COG0003	Pfam Anion-transporting ATPase
H4W23_RS18855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4W23_RS18865	COG1408	metallophosphoesterase
H4W23_RS18920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4W23_RS18925	COG0515	serine threonine protein kinase
H4W23_RS18925	COG2815	serine threonine protein kinase
H4W23_RS18935	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H4W23_RS19015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4W23_RS19020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4W23_RS19035	COG1802	Transcriptional regulator
H4W23_RS19040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4W23_RS19045	COG0693	protein deglycase activity
H4W23_RS19085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4W23_RS19110	COG0583	DNA-binding transcription factor activity
H4W23_RS19120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4W23_RS19140	COG2197	response regulator
H4W23_RS19145	COG4585	Histidine kinase
H4W23_RS19175	COG0477	Major facilitator Superfamily
H4W23_RS19180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4W23_RS19185	COG0191	fructose-bisphosphate aldolase activity
H4W23_RS19190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4W23_RS19205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4W23_RS19235	COG0542	response to heat
H4W23_RS19265	COG0789	Transcriptional regulator
H4W23_RS19270	COG0484	heat shock protein binding
H4W23_RS19275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4W23_RS19280	COG0443	Heat shock 70 kDa protein
H4W23_RS19290	COG0247	lactate metabolic process
H4W23_RS19290	COG2181	nitrate reductase activity
H4W23_RS19300	COG2197	response regulator
H4W23_RS19330	COG0717	Belongs to the dCTP deaminase family
H4W23_RS19360	COG1278	Cold shock
H4W23_RS19365	COG0513	Belongs to the DEAD box helicase family
H4W23_RS19420	COG0215	cysteine-tRNA ligase activity
H4W23_RS19430	COG4585	Histidine kinase
H4W23_RS19435	COG2197	response regulator
H4W23_RS19455	COG1511	domain protein
H4W23_RS19460	COG1595	DNA-templated transcription, initiation
H4W23_RS19520	COG4977	sequence-specific DNA binding
H4W23_RS19525	COG0531	amino acid
H4W23_RS19545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4W23_RS19580	COG1957	nucleoside hydrolase
H4W23_RS19600	COG1051	belongs to the nudix hydrolase family
H4W23_RS19640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H4W23_RS19645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4W23_RS19670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS19675	COG0431	NADPH-dependent FMN reductase
H4W23_RS19725	COG1959	2 iron, 2 sulfur cluster binding
H4W23_RS19730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS19765	COG1289	transmembrane transporter activity
H4W23_RS19790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W23_RS19800	COG2205	protein histidine kinase activity
H4W23_RS19805	COG0745	RESPONSE REGULATOR receiver
H4W23_RS19810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W23_RS19865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4W23_RS19885	COG0628	permease
H4W23_RS19890	COG1741	Belongs to the pirin family
H4W23_RS19900	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS19905	COG1362	aminopeptidase activity
H4W23_RS19940	COG0626	cystathionine gamma-synthase activity
H4W23_RS19945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS19970	COG2271	Major facilitator Superfamily
H4W23_RS19985	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS19990	COG0022	dehydrogenase e1 component
H4W23_RS20015	COG0515	serine threonine protein kinase
H4W23_RS20020	COG0515	serine threonine protein kinase
H4W23_RS20035	COG1136	(ABC) transporter
H4W23_RS20035	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4W23_RS20055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4W23_RS20060	COG0303	'Molybdopterin
H4W23_RS20070	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS20090	COG1309	transcriptional regulator
H4W23_RS20095	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS20120	COG3396	Phenylacetate-CoA oxygenase
H4W23_RS20125	COG3460	Phenylacetate-CoA oxygenase
H4W23_RS20130	COG3396	Phenylacetate-CoA oxygenase
H4W23_RS20135	COG2151	metal-sulfur cluster biosynthetic enzyme
H4W23_RS20140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4W23_RS20150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4W23_RS20175	COG2197	response regulator
H4W23_RS20190	COG1716	ATPase activity
H4W23_RS20195	COG1716	ATPase activity
H4W23_RS20210	COG0768	penicillin binding
H4W23_RS20215	COG0515	serine threonine protein kinase
H4W23_RS20220	COG3764	Sortase (surface protein transpeptidase)
H4W23_RS20225	COG3764	Sortase (surface protein transpeptidase)
H4W23_RS20240	COG3764	Sortase (surface protein transpeptidase)
H4W23_RS20255	COG0705	Rhomboid family
H4W23_RS20280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS20285	COG3629	intracellular signal transduction
H4W23_RS20285	COG3903	Transcriptional regulator
H4W23_RS20300	COG0515	serine threonine protein kinase
H4W23_RS20325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4W23_RS20330	COG0187	DNA topoisomerase II activity
H4W23_RS20335	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H4W23_RS20340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4W23_RS20345	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H4W23_RS20350	COG0592	DNA-directed DNA polymerase activity
H4W23_RS20360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H4W23_RS20365	COG0594	ribonuclease P activity
H4W23_RS20370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4W23_RS20375	COG0706	membrane insertase activity
H4W23_RS20385	COG0357	Ribosomal RNA small subunit methyltransferase G
H4W23_RS20390	COG1192	Involved in chromosome partitioning
H4W23_RS20405	COG3118	belongs to the thioredoxin family
H4W23_RS20410	COG0492	ferredoxin-NADP+ reductase activity
H4W23_RS20420	COG1595	DNA-templated transcription, initiation
H4W23_RS20425	COG2815	serine threonine protein kinase
H4W23_RS20425	COG0515	serine threonine protein kinase
H4W23_RS20440	COG0617	tRNA 3'-terminal CCA addition
H4W23_RS20460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4W23_RS20475	COG2348	transferase activity, transferring amino-acyl groups
H4W23_RS20485	COG0360	Binds together with S18 to 16S ribosomal RNA
H4W23_RS20490	COG0629	single-stranded DNA binding
H4W23_RS20495	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4W23_RS20500	COG0359	binds to the 23S rRNA
H4W23_RS20505	COG0534	Mate efflux family protein
H4W23_RS20510	COG0305	Participates in initiation and elongation during chromosome replication
H4W23_RS20550	COG0494	nUDIX hydrolase
H4W23_RS20560	COG0626	cystathionine gamma-synthase activity
H4W23_RS20565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4W23_RS20570	COG1950	PFAM Membrane protein of
H4W23_RS20575	COG0662	Cupin 2, conserved barrel domain protein
H4W23_RS20600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4W23_RS20615	COG1609	Transcriptional regulator
H4W23_RS20620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4W23_RS20630	COG1271	oxidase subunit
H4W23_RS20635	COG1294	oxidase, subunit
H4W23_RS20640	COG4988	ABC transporter
H4W23_RS20650	COG0561	phosphatase activity
H4W23_RS20685	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H4W23_RS20690	COG0789	Transcriptional regulator
H4W23_RS20705	COG1131	(ABC) transporter
H4W23_RS20725	COG2807	transmembrane transport
H4W23_RS20730	COG2186	Transcriptional regulator
H4W23_RS20750	COG0561	phosphatase activity
H4W23_RS20755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4W23_RS20765	COG2837	iron assimilation
H4W23_RS20780	COG1999	signal sequence binding
H4W23_RS20800	COG0006	proline dipeptidase activity
H4W23_RS20820	COG0653	protein targeting
H4W23_RS20835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4W23_RS20845	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4W23_RS20855	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS20865	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS20885	COG1595	DNA-templated transcription, initiation
H4W23_RS20890	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS20895	COG0784	Response regulator, receiver
H4W23_RS20945	COG0745	RESPONSE REGULATOR receiver
H4W23_RS20950	COG2205	protein histidine kinase activity
H4W23_RS20960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4W23_RS20965	COG0477	Major facilitator Superfamily
H4W23_RS20975	COG0477	Major facilitator Superfamily
H4W23_RS20990	COG1309	transcriptional regulator
H4W23_RS21005	COG1191	sigma factor activity
H4W23_RS21010	COG1191	sigma factor activity
H4W23_RS21045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4W23_RS21060	COG0433	COG0433 Predicted ATPase
H4W23_RS21065	COG2234	aminopeptidase activity
H4W23_RS21075	COG2267	carboxylic ester hydrolase activity
H4W23_RS21085	COG1309	transcriptional regulator
H4W23_RS21090	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4W23_RS21095	COG1937	Protein conserved in bacteria
H4W23_RS21110	COG3795	YCII-related domain
H4W23_RS21115	COG2095	MarC family integral membrane protein
H4W23_RS21125	COG0667	Aldo Keto reductase
H4W23_RS21130	COG2267	carboxylic ester hydrolase activity
H4W23_RS21155	COG1136	(ABC) transporter
H4W23_RS21180	COG1309	transcriptional regulator
H4W23_RS21205	COG0151	Belongs to the GarS family
H4W23_RS21220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4W23_RS21230	COG2197	response regulator
H4W23_RS21235	COG3850	Histidine kinase
H4W23_RS21265	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4W23_RS21270	COG0047	phosphoribosylformylglycinamidine synthase activity
H4W23_RS21275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4W23_RS21310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4W23_RS21345	COG1643	Atp-dependent helicase
H4W23_RS21355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4W23_RS21355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4W23_RS21360	COG0785	Cytochrome C biogenesis protein
H4W23_RS21390	COG0513	Belongs to the DEAD box helicase family
H4W23_RS21420	COG1597	lipid kinase activity
H4W23_RS21430	COG1595	DNA-templated transcription, initiation
H4W23_RS21445	COG0789	Transcriptional regulator
H4W23_RS21455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4W23_RS21470	COG1196	nuclear chromosome segregation
H4W23_RS21470	COG0739	heme binding
H4W23_RS21470	COG0741	lytic transglycosylase activity
H4W23_RS21475	COG0667	Aldo Keto reductase
H4W23_RS21490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4W23_RS21495	COG0579	oxidoreductase
H4W23_RS21530	COG1252	NADH dehydrogenase
H4W23_RS21545	COG1846	Transcriptional regulator
H4W23_RS21580	COG2197	response regulator
H4W23_RS21585	COG4585	Histidine kinase
H4W23_RS21595	COG1131	(ABC) transporter
H4W23_RS21635	COG1309	transcriptional regulator
H4W23_RS21645	COG1196	nuclear chromosome segregation
H4W23_RS21645	COG0741	lytic transglycosylase activity
H4W23_RS21645	COG0739	heme binding
H4W23_RS21650	COG0671	phosphoesterase, PA-phosphatase related
H4W23_RS21665	COG1937	Protein conserved in bacteria
H4W23_RS21675	COG0306	phosphate transporter
H4W23_RS21695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4W23_RS21725	COG1725	Transcriptional regulator
H4W23_RS21730	COG0456	acetyltransferase
H4W23_RS21735	COG0737	Belongs to the 5'-nucleotidase family
H4W23_RS21740	COG0823	Involved in the tonB-independent uptake of proteins
H4W23_RS21750	COG0745	RESPONSE REGULATOR receiver
H4W23_RS21755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4W23_RS21760	COG1609	Transcriptional regulator
H4W23_RS21765	COG0745	RESPONSE REGULATOR receiver
H4W23_RS21790	COG2897	thiosulfate sulfurtransferase activity
H4W23_RS21825	COG3485	protocatechuate 3,4-dioxygenase
H4W23_RS21835	COG0354	folic acid binding
H4W23_RS21840	COG1490	D-aminoacyl-tRNA deacylase activity
H4W23_RS21850	COG4552	Acetyltransferase involved in intracellular survival and related
H4W23_RS21885	COG0346	lactoylglutathione lyase activity
H4W23_RS21925	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS21945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4W23_RS21955	COG0588	phosphoglycerate mutase activity
H4W23_RS21980	COG5002	protein histidine kinase activity
H4W23_RS21995	COG1329	Transcriptional regulator
H4W23_RS22000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4W23_RS22005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4W23_RS22010	COG0215	cysteine-tRNA ligase activity
H4W23_RS22030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H4W23_RS22040	COG3842	ATPase activity
H4W23_RS22050	COG4974	Belongs to the 'phage' integrase family
H4W23_RS22225	COG2188	Transcriptional regulator
H4W23_RS22230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H4W23_RS22255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W23_RS22300	COG2197	response regulator
H4W23_RS22335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4W23_RS22380	COG0561	phosphatase activity
H4W23_RS22380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS22390	COG1733	regulation of RNA biosynthetic process
H4W23_RS22405	COG0463	Glycosyl transferase, family 2
H4W23_RS22425	COG0459	protein refolding
H4W23_RS22475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4W23_RS22480	COG1737	Transcriptional regulator
H4W23_RS22560	COG0626	cystathionine gamma-synthase activity
H4W23_RS22565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4W23_RS22575	COG4106	trans-aconitate 2-methyltransferase activity
H4W23_RS22590	COG0736	holo-[acyl-carrier-protein] synthase activity
H4W23_RS22605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W23_RS22610	COG0646	methionine synthase
H4W23_RS22610	COG1410	methionine synthase
H4W23_RS22655	COG1113	amino acid transport
H4W23_RS22675	COG1741	Belongs to the pirin family
H4W23_RS22685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H4W23_RS22715	COG2318	DinB family
H4W23_RS22735	COG0367	asparagine synthase
H4W23_RS22750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W23_RS22750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W23_RS22755	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS22800	COG1937	Protein conserved in bacteria
H4W23_RS22820	COG3142	Participates in the control of copper homeostasis
H4W23_RS22825	COG2197	response regulator
H4W23_RS22830	COG4585	Histidine kinase
H4W23_RS22845	COG0346	lactoylglutathione lyase activity
H4W23_RS22850	COG3973	AAA domain
H4W23_RS22865	COG1061	Type III restriction enzyme res subunit
H4W23_RS22880	COG1120	ATPase activity
H4W23_RS22885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS22890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS22905	COG1278	Cold shock
H4W23_RS22910	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H4W23_RS22915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4W23_RS22925	COG2814	Major facilitator Superfamily
H4W23_RS22980	COG1136	(ABC) transporter
H4W23_RS22990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4W23_RS23000	COG2252	PERMEase
H4W23_RS23030	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4W23_RS23035	COG0667	Aldo Keto reductase
H4W23_RS23060	COG2267	carboxylic ester hydrolase activity
H4W23_RS23085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4W23_RS23090	COG0277	FAD linked oxidase domain protein
H4W23_RS23100	COG3123	guanosine phosphorylase activity
H4W23_RS23105	COG2318	DinB family
H4W23_RS23120	COG0583	DNA-binding transcription factor activity
H4W23_RS23140	COG3467	pyridoxamine 5'-phosphate
H4W23_RS23165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4W23_RS23200	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS23210	COG1309	transcriptional regulator
H4W23_RS23230	COG0259	pyridoxamine-phosphate oxidase activity
H4W23_RS23240	COG4821	SIS domain
H4W23_RS23250	COG2945	thiolester hydrolase activity
H4W23_RS23250	COG0596	Alpha beta hydrolase
H4W23_RS23290	COG4152	abc transporter atp-binding protein
H4W23_RS23345	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS23355	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS23360	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS23375	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS23415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4W23_RS23425	COG1024	Enoyl-CoA hydratase
H4W23_RS23440	COG2072	flavoprotein involved in K transport
H4W23_RS23455	COG0515	serine threonine protein kinase
H4W23_RS23455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS23485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS23540	COG1196	nuclear chromosome segregation
H4W23_RS23540	COG0741	lytic transglycosylase activity
H4W23_RS23540	COG0739	heme binding
H4W23_RS23545	COG1278	Cold shock
H4W23_RS23550	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H4W23_RS23555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H4W23_RS23575	COG2226	methyltransferase
H4W23_RS23615	COG1136	(ABC) transporter
H4W23_RS23620	COG0577	efflux transmembrane transporter activity
H4W23_RS23620	COG1136	(ABC) transporter
H4W23_RS23635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23645	COG0649	NAD binding
H4W23_RS23655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4W23_RS23660	COG1034	ATP synthesis coupled electron transport
H4W23_RS23665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4W23_RS23670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23675	COG0839	Belongs to the complex I subunit 6 family
H4W23_RS23680	COG0713	ATP synthesis coupled electron transport
H4W23_RS23685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4W23_RS23695	COG1007	ATP synthesis coupled electron transport
H4W23_RS23700	COG2207	Transcriptional regulator
H4W23_RS23710	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4W23_RS23725	COG3104	oligopeptide transport
H4W23_RS23730	COG0142	geranyltranstransferase activity
H4W23_RS23785	COG1733	regulation of RNA biosynthetic process
H4W23_RS23800	COG0702	epimerase
H4W23_RS23805	COG1733	regulation of RNA biosynthetic process
H4W23_RS23825	COG1013	pyruvate-flavodoxin oxidoreductase activity
H4W23_RS23830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H4W23_RS23830	COG0674	pyruvate-flavodoxin oxidoreductase activity
H4W23_RS23850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4W23_RS23870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W23_RS23875	COG0839	Belongs to the complex I subunit 6 family
H4W23_RS23880	COG0713	ATP synthesis coupled electron transport
H4W23_RS23895	COG1007	ATP synthesis coupled electron transport
H4W23_RS23905	COG0501	Belongs to the peptidase M48B family
H4W23_RS23910	COG3304	Inner membrane component domain
H4W23_RS23930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4W23_RS23935	COG1666	GTP binding
H4W23_RS23945	COG0702	epimerase
H4W23_RS23950	COG0402	S-adenosylhomocysteine deaminase activity
H4W23_RS23965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H4W23_RS23970	COG2030	dehydratase
H4W23_RS23980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4W23_RS23985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4W23_RS23995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4W23_RS24000	COG0436	Aminotransferase
H4W23_RS24010	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4W23_RS24020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4W23_RS24025	COG0081	regulation of translation
H4W23_RS24035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4W23_RS24040	COG0222	ribosome binding
H4W23_RS24045	COG0085	RNA polymerase activity
H4W23_RS24050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4W23_RS24175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4W23_RS24180	COG0049	tRNA binding
H4W23_RS24185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4W23_RS24190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4W23_RS24200	COG4941	Belongs to the sigma-70 factor family
H4W23_RS24205	COG0051	transcription antitermination factor activity, RNA binding
H4W23_RS24210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H4W23_RS24215	COG0088	Forms part of the polypeptide exit tunnel
H4W23_RS24220	COG0089	rRNA binding
H4W23_RS24225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4W23_RS24230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4W23_RS24235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4W23_RS24240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4W23_RS24245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4W23_RS24250	COG0255	Belongs to the universal ribosomal protein uL29 family
H4W23_RS24255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4W23_RS24260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4W23_RS24265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4W23_RS24270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4W23_RS24275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4W23_RS24280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H4W23_RS24285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4W23_RS24290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4W23_RS24295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H4W23_RS24300	COG1841	ribosomal large subunit assembly
H4W23_RS24305	COG0200	Binds to the 23S rRNA
H4W23_RS24315	COG0563	adenylate kinase activity
H4W23_RS24325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4W23_RS24330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4W23_RS24335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4W23_RS24340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4W23_RS24345	COG0202	RNA polymerase activity
H4W23_RS24350	COG0203	ribosomal protein L17
H4W23_RS24355	COG0101	tRNA pseudouridine synthase activity
H4W23_RS24365	COG0488	(ABC) transporter
H4W23_RS24370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H4W23_RS24375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4W23_RS24380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4W23_RS24390	COG1072	(Pantothenic acid kinase))
H4W23_RS24400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W23_RS24405	COG0736	holo-[acyl-carrier-protein] synthase activity
H4W23_RS24430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4W23_RS24440	COG0802	atpase or kinase
H4W23_RS24465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4W23_RS24475	COG0726	polysaccharide deacetylase
H4W23_RS24485	COG4941	Belongs to the sigma-70 factor family
H4W23_RS24505	COG0726	polysaccharide deacetylase
H4W23_RS24520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4W23_RS24540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4W23_RS24545	COG0395	ABC-type sugar transport system, permease component
H4W23_RS24550	COG1175	transmembrane transport
H4W23_RS24560	COG1609	Transcriptional regulator
H4W23_RS24570	COG4221	oxidoreductase activity
H4W23_RS24580	COG0583	DNA-binding transcription factor activity
H4W23_RS24595	COG1595	DNA-templated transcription, initiation
H4W23_RS24605	COG0516	GMP reductase activity
H4W23_RS24620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4W23_RS24635	COG0515	serine threonine protein kinase
H4W23_RS24640	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS24655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4W23_RS24655	COG0519	Catalyzes the synthesis of GMP from XMP
H4W23_RS24690	COG2197	response regulator
H4W23_RS24720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS24740	COG0714	Associated with various cellular activities
H4W23_RS24745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H4W23_RS24750	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H4W23_RS24755	COG0045	succinate-CoA ligase (ADP-forming) activity
H4W23_RS24785	COG0138	bifunctional purine biosynthesis protein purh
H4W23_RS24815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4W23_RS24830	COG0039	L-malate dehydrogenase activity
H4W23_RS24850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS24855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS24870	COG0754	glutathionylspermidine amidase activity
H4W23_RS24875	COG0726	polysaccharide deacetylase
H4W23_RS24895	COG1136	(ABC) transporter
H4W23_RS24900	COG1136	(ABC) transporter
H4W23_RS24900	COG0577	efflux transmembrane transporter activity
H4W23_RS24905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4W23_RS24920	COG0180	Tryptophanyl-tRNA synthetase
H4W23_RS24940	COG1686	Belongs to the peptidase S11 family
H4W23_RS24950	COG1408	metallophosphoesterase
H4W23_RS24955	COG0747	negative chemotaxis
H4W23_RS24985	COG1846	Transcriptional regulator
H4W23_RS24995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4W23_RS25000	COG1053	succinate dehydrogenase
H4W23_RS25010	COG2009	succinate dehydrogenase
H4W23_RS25035	COG1595	DNA-templated transcription, initiation
H4W23_RS25050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS25050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS25070	COG1216	Glycosyl transferase, family 2
H4W23_RS25085	COG2089	acid synthase
H4W23_RS25095	COG1473	amidohydrolase
H4W23_RS25095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4W23_RS25115	COG1744	ABC transporter substrate-binding protein PnrA-like
H4W23_RS25120	COG3845	ABC transporter
H4W23_RS25125	COG4603	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS25130	COG1079	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS25145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS25165	COG2814	Major facilitator Superfamily
H4W23_RS25170	COG0583	DNA-binding transcription factor activity
H4W23_RS25175	COG2124	cytochrome p450
H4W23_RS25190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4W23_RS25215	COG2205	protein histidine kinase activity
H4W23_RS25220	COG0745	RESPONSE REGULATOR receiver
H4W23_RS25225	COG1595	DNA-templated transcription, initiation
H4W23_RS25245	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS25250	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS25315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4W23_RS25320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4W23_RS25340	COG1349	DNA-binding transcription factor activity
H4W23_RS25350	COG4770	biotin carboxylase activity
H4W23_RS25360	COG0424	maF-like protein
H4W23_RS25380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4W23_RS25395	COG1024	Enoyl-CoA hydratase
H4W23_RS25405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4W23_RS25455	COG2986	histidine ammonia-lyase
H4W23_RS25480	COG1064	alcohol dehydrogenase
H4W23_RS25490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4W23_RS25495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W23_RS25500	COG1672	PFAM Archaeal ATPase
H4W23_RS25500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H4W23_RS25590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4W23_RS25625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4W23_RS25640	COG0515	serine threonine protein kinase
H4W23_RS25640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS25645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS25645	COG0515	serine threonine protein kinase
H4W23_RS25650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4W23_RS25660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4W23_RS25670	COG3842	ATPase activity
H4W23_RS25680	COG1331	Highly conserved protein containing a thioredoxin domain
H4W23_RS25690	COG1316	TRANSCRIPTIONal
H4W23_RS25735	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS25745	COG0728	peptidoglycan biosynthetic process
H4W23_RS25755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4W23_RS25760	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS25830	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H4W23_RS25835	COG4195	phage-related replication protein
H4W23_RS25885	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4W23_RS25900	COG1414	Transcriptional regulator
H4W23_RS25905	COG0251	oxidation-reduction process
H4W23_RS25935	COG2894	cell division
H4W23_RS25985	COG2885	chlorophyll binding
H4W23_RS26010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4W23_RS26015	COG0667	Aldo Keto reductase
H4W23_RS26020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4W23_RS26025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4W23_RS26045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS26050	COG0450	alkyl hydroperoxide reductase
H4W23_RS26065	COG1136	(ABC) transporter
H4W23_RS26075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H4W23_RS26090	COG0114	fumarate hydratase activity
H4W23_RS26115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H4W23_RS26115	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H4W23_RS26140	COG0778	Nitroreductase
H4W23_RS26145	COG1722	exodeoxyribonuclease VII activity
H4W23_RS26150	COG1570	exodeoxyribonuclease VII activity
H4W23_RS26155	COG0531	amino acid
H4W23_RS26160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4W23_RS26175	COG0012	GTP binding
H4W23_RS26180	COG3629	intracellular signal transduction
H4W23_RS26180	COG3903	Transcriptional regulator
H4W23_RS26230	COG1842	Phage shock protein A
H4W23_RS26250	COG1053	succinate dehydrogenase
H4W23_RS26270	COG1217	gtp-binding protein TYPA
H4W23_RS26280	COG0601	transmembrane transport
H4W23_RS26285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS26290	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS26295	COG4608	Belongs to the ABC transporter superfamily
H4W23_RS26300	COG4166	transmembrane transport
H4W23_RS26305	COG0601	transmembrane transport
H4W23_RS26310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS26315	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS26320	COG4608	Belongs to the ABC transporter superfamily
H4W23_RS26340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4W23_RS26375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS26375	COG0515	serine threonine protein kinase
H4W23_RS26380	COG0515	serine threonine protein kinase
H4W23_RS26380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W23_RS26415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4W23_RS26420	COG1611	Belongs to the LOG family
H4W23_RS26425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4W23_RS26435	COG0519	Catalyzes the synthesis of GMP from XMP
H4W23_RS26445	COG1024	Enoyl-CoA hydratase
H4W23_RS26460	COG1595	DNA-templated transcription, initiation
H4W23_RS26470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4W23_RS26475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4W23_RS26510	COG0598	Magnesium transport protein CorA
H4W23_RS26530	COG2095	MarC family integral membrane protein
H4W23_RS26540	COG1432	Conserved Protein
H4W23_RS26550	COG0513	Belongs to the DEAD box helicase family
H4W23_RS26595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS26600	COG0601	transmembrane transport
H4W23_RS26610	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS26675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4W23_RS26715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4W23_RS26770	COG3480	Lon protease (S16) C-terminal proteolytic domain
H4W23_RS26780	COG1615	UPF0182 protein
H4W23_RS26805	COG0753	catalase activity
H4W23_RS26815	COG0483	inositol monophosphate 1-phosphatase activity
H4W23_RS26825	COG2076	Multidrug Resistance protein
H4W23_RS26835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4W23_RS26845	COG2135	peptidase activity
H4W23_RS26855	COG1595	DNA-templated transcription, initiation
H4W23_RS26860	COG5662	AntiSigma factor
H4W23_RS26865	COG2199	diguanylate cyclase activity
H4W23_RS26865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H4W23_RS26880	COG0242	peptide deformylase activity
H4W23_RS26910	COG2188	Transcriptional regulator
H4W23_RS26915	COG2182	Extracellular solute-binding protein
H4W23_RS26920	COG1175	transmembrane transport
H4W23_RS26925	COG0395	ABC-type sugar transport system, permease component
H4W23_RS26930	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W23_RS26935	COG0363	glucosamine-6-phosphate deaminase activity
H4W23_RS26940	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS26960	COG1597	lipid kinase activity
H4W23_RS26990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H4W23_RS27000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4W23_RS27005	COG0142	geranyltranstransferase activity
H4W23_RS27030	COG5640	endopeptidase activity
H4W23_RS27065	COG4106	trans-aconitate 2-methyltransferase activity
H4W23_RS27070	COG1126	abc transporter atp-binding protein
H4W23_RS27075	COG0765	amino acid transport
H4W23_RS27080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS27090	COG0604	alcohol dehydrogenase
H4W23_RS27120	COG0567	Dehydrogenase, E1 component
H4W23_RS27120	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS27125	COG2205	protein histidine kinase activity
H4W23_RS27130	COG0745	RESPONSE REGULATOR receiver
H4W23_RS27140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4W23_RS27155	COG0675	Transposase, IS605 OrfB family
H4W23_RS27180	COG1595	DNA-templated transcription, initiation
H4W23_RS27195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4W23_RS27215	COG1846	Transcriptional regulator
H4W23_RS27250	COG0789	Transcriptional regulator
H4W23_RS27270	COG3883	PFAM NLP P60 protein
H4W23_RS27270	COG0791	NLP P60 protein
H4W23_RS27295	COG0768	penicillin binding
H4W23_RS27300	COG0772	Belongs to the SEDS family
H4W23_RS27305	COG2205	protein histidine kinase activity
H4W23_RS27325	COG3285	dna ligase
H4W23_RS27325	COG1793	dna ligase
H4W23_RS27330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4W23_RS27340	COG1309	transcriptional regulator
H4W23_RS27370	COG0018	arginyl-trna synthetase
H4W23_RS27370	COG0018	arginyl-trna synthetase
H4W23_RS27375	COG0019	diaminopimelate decarboxylase activity
H4W23_RS27380	COG0460	homoserine dehydrogenase
H4W23_RS27385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4W23_RS27390	COG0083	homoserine kinase activity
H4W23_RS27400	COG1316	TRANSCRIPTIONal
H4W23_RS27405	COG0254	rRNA binding
H4W23_RS27410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4W23_RS27415	COG2890	protein-(glutamine-N5) methyltransferase activity
H4W23_RS27425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4W23_RS27440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4W23_RS27460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4W23_RS27465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4W23_RS27470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4W23_RS27475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4W23_RS27480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4W23_RS27485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4W23_RS27490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4W23_RS27505	COG2197	response regulator
H4W23_RS27510	COG4585	Histidine kinase
H4W23_RS27540	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS27555	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H4W23_RS27610	COG0183	Belongs to the thiolase family
H4W23_RS27660	COG1309	transcriptional regulator
H4W23_RS27700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS27700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS27735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4W23_RS27740	COG0857	belongs to the CobB CobQ family
H4W23_RS27740	COG0280	phosphate acetyltransferase
H4W23_RS27745	COG0205	6-phosphofructokinase activity
H4W23_RS27765	COG4565	transcriptional regulatory protein
H4W23_RS27770	COG3290	protein histidine kinase activity
H4W23_RS27775	COG1301	dicarboxylic acid transport
H4W23_RS27780	COG0667	Aldo Keto reductase
H4W23_RS27790	COG1522	sequence-specific DNA binding
H4W23_RS27795	COG0789	Transcriptional regulator
H4W23_RS27800	COG3118	belongs to the thioredoxin family
H4W23_RS27810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4W23_RS27820	COG0366	Alpha amylase catalytic
H4W23_RS27825	COG0366	Alpha amylase catalytic
H4W23_RS27860	COG0058	SHG alpha-glucan phosphorylase activity
H4W23_RS27865	COG4585	Histidine kinase
H4W23_RS27885	COG0477	Major facilitator Superfamily
H4W23_RS27890	COG1132	(ABC) transporter
H4W23_RS27895	COG1132	(ABC) transporter
H4W23_RS27900	COG1131	(ABC) transporter
H4W23_RS27910	COG4585	Histidine kinase
H4W23_RS27925	COG1376	ErfK ybiS ycfS ynhG family protein
H4W23_RS27945	COG0726	polysaccharide deacetylase
H4W23_RS27980	COG1760	l-serine dehydratase
H4W23_RS27985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4W23_RS27990	COG0509	glycine decarboxylation via glycine cleavage system
H4W23_RS27995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4W23_RS28020	COG4166	transmembrane transport
H4W23_RS28025	COG0601	transmembrane transport
H4W23_RS28030	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS28035	COG4608	Belongs to the ABC transporter superfamily
H4W23_RS28040	COG2860	membrane
H4W23_RS28060	COG0482	sulfurtransferase activity
H4W23_RS28070	COG1611	Belongs to the LOG family
H4W23_RS28075	COG4221	oxidoreductase activity
H4W23_RS28085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4W23_RS28095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4W23_RS28100	COG0154	amidase activity
H4W23_RS28110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4W23_RS28140	COG3511	phospholipase C
H4W23_RS28145	COG2409	Drug exporters of the RND superfamily
H4W23_RS28150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4W23_RS28165	COG2197	response regulator
H4W23_RS28170	COG2133	pyrroloquinoline quinone binding
H4W23_RS28175	COG0667	Aldo Keto reductase
H4W23_RS28195	COG0440	acetolactate synthase activity
H4W23_RS28200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4W23_RS28205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4W23_RS28235	COG0506	proline dehydrogenase activity
H4W23_RS28240	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS28260	COG1695	Transcriptional regulator
H4W23_RS28270	COG0583	DNA-binding transcription factor activity
H4W23_RS28275	COG0473	3-isopropylmalate dehydrogenase activity
H4W23_RS28280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4W23_RS28290	COG2957	Belongs to the agmatine deiminase family
H4W23_RS28300	COG1595	DNA-templated transcription, initiation
H4W23_RS28310	COG0477	Major facilitator Superfamily
H4W23_RS28315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4W23_RS28325	COG0592	DNA-directed DNA polymerase activity
H4W23_RS28345	COG2353	YceI-like domain
H4W23_RS28355	COG1470	cell adhesion involved in biofilm formation
H4W23_RS28355	COG0366	Alpha amylase catalytic
H4W23_RS28360	COG5492	domain, Protein
H4W23_RS28365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4W23_RS28385	COG2018	Roadblock/LC7 domain
H4W23_RS28405	COG2018	Roadblock/LC7 domain
H4W23_RS28410	COG5002	protein histidine kinase activity
H4W23_RS28420	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4W23_RS28425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4W23_RS28430	COG1011	Hydrolase
H4W23_RS28460	COG1414	Transcriptional regulator
H4W23_RS28465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4W23_RS28470	COG0066	3-isopropylmalate dehydratase activity
H4W23_RS28480	COG0776	regulation of translation
H4W23_RS28490	COG1920	GTP binding
H4W23_RS28500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4W23_RS28505	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4W23_RS28525	COG0351	phosphomethylpyrimidine kinase
H4W23_RS28530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4W23_RS28535	COG1461	Dihydroxyacetone kinase
H4W23_RS28540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4W23_RS28545	COG0742	ribosomal rna small subunit methyltransferase
H4W23_RS28550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4W23_RS28565	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4W23_RS28570	COG0571	ribonuclease III activity
H4W23_RS28575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4W23_RS28580	COG1733	regulation of RNA biosynthetic process
H4W23_RS28585	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4W23_RS28590	COG2340	Cysteine-rich secretory protein family
H4W23_RS28595	COG1254	Belongs to the acylphosphatase family
H4W23_RS28610	COG0477	Major facilitator Superfamily
H4W23_RS28620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4W23_RS28650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H4W23_RS28660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4W23_RS28675	COG0228	four-way junction DNA binding
H4W23_RS28680	COG1837	Belongs to the UPF0109 family
H4W23_RS28685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4W23_RS28690	COG0336	Belongs to the RNA methyltransferase TrmD family
H4W23_RS28695	COG0335	large ribosomal subunit rRNA binding
H4W23_RS28715	COG0681	Belongs to the peptidase S26 family
H4W23_RS28730	COG0792	nuclease activity
H4W23_RS28745	COG1191	sigma factor activity
H4W23_RS28760	COG0052	Belongs to the universal ribosomal protein uS2 family
H4W23_RS28765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4W23_RS28770	COG0528	UMP kinase activity
H4W23_RS28775	COG0233	cytoplasmic translational termination
H4W23_RS28780	COG0575	Belongs to the CDS family
H4W23_RS28785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4W23_RS28795	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4W23_RS28800	COG3842	ATPase activity
H4W23_RS28810	COG4181	ATPase activity
H4W23_RS28815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4W23_RS28825	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS28860	COG2197	response regulator
H4W23_RS28865	COG4585	Histidine kinase
H4W23_RS28880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4W23_RS28900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4W23_RS28905	COG3842	ATPase activity
H4W23_RS28910	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4W23_RS28915	COG1177	transmembrane transport
H4W23_RS28920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W23_RS28925	COG2409	Drug exporters of the RND superfamily
H4W23_RS28965	COG0697	spore germination
H4W23_RS28970	COG1012	belongs to the aldehyde dehydrogenase family
H4W23_RS28980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4W23_RS28985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4W23_RS28990	COG0750	zinc metalloprotease
H4W23_RS28995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H4W23_RS29010	COG0442	prolyl-tRNA aminoacylation
H4W23_RS29015	COG0330	HflC and HflK could
H4W23_RS29035	COG0779	Required for maturation of 30S ribosomal subunits
H4W23_RS29050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4W23_RS29060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4W23_RS29065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4W23_RS29085	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS29095	COG0601	transmembrane transport
H4W23_RS29100	COG4166	transmembrane transport
H4W23_RS29105	COG0455	bacterial-type flagellum organization
H4W23_RS29120	COG3266	domain, Protein
H4W23_RS29125	COG1404	Belongs to the peptidase S8 family
H4W23_RS29145	COG1674	ftsk spoiiie
H4W23_RS29155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4W23_RS29160	COG1185	polyribonucleotide nucleotidyltransferase activity
H4W23_RS29165	COG0612	Peptidase, M16
H4W23_RS29170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4W23_RS29190	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H4W23_RS29195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4W23_RS29200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4W23_RS29225	COG2770	Histidine kinase
H4W23_RS29225	COG2208	phosphoserine phosphatase activity
H4W23_RS29230	COG4999	Histidine kinase
H4W23_RS29230	COG3850	Histidine kinase
H4W23_RS29230	COG3437	response regulator, receiver
H4W23_RS29230	COG2205	protein histidine kinase activity
H4W23_RS29240	COG1674	ftsk spoiiie
H4W23_RS29250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4W23_RS29260	COG1546	Belongs to the CinA family
H4W23_RS29260	COG1058	Belongs to the CinA family
H4W23_RS29265	COG1396	sequence-specific DNA binding
H4W23_RS29270	COG0783	Belongs to the Dps family
H4W23_RS29275	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS29280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4W23_RS29285	COG1201	RNA secondary structure unwinding
H4W23_RS29290	COG2207	Transcriptional regulator
H4W23_RS29290	COG1917	Cupin 2, conserved barrel domain protein
H4W23_RS29325	COG1271	oxidase subunit
H4W23_RS29330	COG2197	response regulator
H4W23_RS29335	COG4585	Histidine kinase
H4W23_RS29355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4W23_RS29380	COG0765	amino acid transport
H4W23_RS29385	COG0765	amino acid transport
H4W23_RS29390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS29395	COG1126	abc transporter atp-binding protein
H4W23_RS29400	COG0745	RESPONSE REGULATOR receiver
H4W23_RS29445	COG0583	DNA-binding transcription factor activity
H4W23_RS29460	COG2197	response regulator
H4W23_RS29465	COG4585	Histidine kinase
H4W23_RS29470	COG0586	Pfam SNARE associated Golgi protein
H4W23_RS29475	COG0494	nUDIX hydrolase
H4W23_RS29485	COG1349	DNA-binding transcription factor activity
H4W23_RS29490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4W23_RS29510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4W23_RS29520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4W23_RS29525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4W23_RS29535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4W23_RS29575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4W23_RS29580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4W23_RS29585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4W23_RS29630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4W23_RS29665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4W23_RS29670	COG2186	Transcriptional regulator
H4W23_RS29675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4W23_RS29690	COG0187	DNA topoisomerase II activity
H4W23_RS29700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4W23_RS29710	COG3290	protein histidine kinase activity
H4W23_RS29720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4W23_RS29725	COG0612	Peptidase, M16
H4W23_RS29740	COG1802	Transcriptional regulator
H4W23_RS29745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4W23_RS29765	COG1435	thymidine kinase activity
H4W23_RS29775	COG4977	sequence-specific DNA binding
H4W23_RS29835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4W23_RS29850	COG0745	RESPONSE REGULATOR receiver
H4W23_RS29855	COG2205	protein histidine kinase activity
H4W23_RS29880	COG0756	dUTP diphosphatase activity
H4W23_RS29890	COG1136	(ABC) transporter
H4W23_RS29890	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4W23_RS29920	COG0569	domain protein
H4W23_RS29925	COG0531	amino acid
H4W23_RS29930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4W23_RS29940	COG2235	arginine
H4W23_RS29975	COG3851	Histidine kinase
H4W23_RS29980	COG2197	response regulator
H4W23_RS29985	COG2890	protein-(glutamine-N5) methyltransferase activity
H4W23_RS29990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4W23_RS30000	COG3938	Belongs to the proline racemase family
H4W23_RS30010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W23_RS30015	COG1799	cell septum assembly
H4W23_RS30045	COG2040	homocysteine
H4W23_RS30055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4W23_RS30110	COG2235	arginine
H4W23_RS30115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4W23_RS30125	COG1024	Enoyl-CoA hydratase
H4W23_RS30175	COG0477	Major facilitator Superfamily
H4W23_RS30185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4W23_RS30200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4W23_RS30210	COG1653	transport
H4W23_RS30215	COG1175	transmembrane transport
H4W23_RS30220	COG0395	ABC-type sugar transport system, permease component
H4W23_RS30225	COG1940	carbohydrate kinase activity
H4W23_RS30230	COG4213	ABC transporter substrate-binding protein
H4W23_RS30240	COG4214	carbohydrate transport
H4W23_RS30245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4W23_RS30250	COG0531	amino acid
H4W23_RS30260	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS30260	COG1024	Enoyl-CoA hydratase
H4W23_RS30265	COG0183	Belongs to the thiolase family
H4W23_RS30275	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H4W23_RS30290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4W23_RS30300	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4W23_RS30310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H4W23_RS30315	COG3253	May function as heme-dependent peroxidase
H4W23_RS30330	COG3220	belongs to the UPF0276 family
H4W23_RS30355	COG1116	anion transmembrane transporter activity
H4W23_RS30375	COG2326	polyphosphate kinase activity
H4W23_RS30405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4W23_RS30410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4W23_RS30440	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS30460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4W23_RS30485	COG0346	lactoylglutathione lyase activity
H4W23_RS30500	COG0504	CTP synthase activity
H4W23_RS30595	COG1175	transmembrane transport
H4W23_RS30615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4W23_RS30625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4W23_RS30630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4W23_RS30650	COG0529	Catalyzes the synthesis of activated sulfate
H4W23_RS30655	COG0175	sulfate reduction
H4W23_RS30680	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS30795	COG4974	Belongs to the 'phage' integrase family
H4W23_RS30825	COG1162	GTPase activity
H4W23_RS30850	COG1404	Belongs to the peptidase S8 family
H4W23_RS30860	COG0028	Belongs to the TPP enzyme family
H4W23_RS30880	COG1802	Transcriptional regulator
H4W23_RS30920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4W23_RS30925	COG2252	PERMEase
H4W23_RS30940	COG1309	transcriptional regulator
H4W23_RS30945	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS30960	COG0583	DNA-binding transcription factor activity
H4W23_RS30995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H4W23_RS31020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4W23_RS31025	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS31030	COG1309	transcriptional regulator
H4W23_RS31040	COG2814	Major facilitator Superfamily
H4W23_RS31060	COG0640	Transcriptional regulator
H4W23_RS31065	COG2814	Major facilitator Superfamily
H4W23_RS31085	COG2066	Belongs to the glutaminase family
H4W23_RS31115	COG0009	L-threonylcarbamoyladenylate synthase
H4W23_RS31135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4W23_RS31140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4W23_RS31145	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H4W23_RS31155	COG3795	YCII-related domain
H4W23_RS31160	COG4941	Belongs to the sigma-70 factor family
H4W23_RS31170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4W23_RS31170	COG2080	2 iron, 2 sulfur cluster binding
H4W23_RS31175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4W23_RS31180	COG3835	regulator
H4W23_RS31200	COG1309	transcriptional regulator
H4W23_RS31210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W23_RS31240	COG1120	ATPase activity
H4W23_RS31245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS31265	COG1335	isochorismatase
H4W23_RS31270	COG2259	Doxx family
H4W23_RS31275	COG0783	Belongs to the Dps family
H4W23_RS31280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4W23_RS31315	COG1653	transport
H4W23_RS31320	COG1175	transmembrane transport
H4W23_RS31325	COG0395	ABC-type sugar transport system, permease component
H4W23_RS31330	COG2197	response regulator
H4W23_RS31340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS31355	COG2508	Transcriptional regulator
H4W23_RS31375	COG0598	Magnesium transport protein CorA
H4W23_RS31390	COG2197	response regulator
H4W23_RS31395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4W23_RS31400	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS31425	COG3960	tartronate-semialdehyde synthase activity
H4W23_RS31445	COG0753	catalase activity
H4W23_RS31450	COG2084	Dehydrogenase
H4W23_RS31455	COG3622	Belongs to the hyi family
H4W23_RS31475	COG2351	hydroxyisourate hydrolase activity
H4W23_RS31485	COG2233	PERMEase
H4W23_RS31495	COG2233	PERMEase
H4W23_RS31525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4W23_RS31550	COG2197	response regulator
H4W23_RS31555	COG4585	Histidine kinase
H4W23_RS31570	COG1414	Transcriptional regulator
H4W23_RS31575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4W23_RS31580	COG4266	Belongs to the allantoicase family
H4W23_RS31585	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS31610	COG2203	Gaf domain
H4W23_RS31610	COG4585	Histidine kinase
H4W23_RS31625	COG0673	inositol 2-dehydrogenase activity
H4W23_RS31630	COG2188	Transcriptional regulator
H4W23_RS31645	COG1129	ABC transporter
H4W23_RS31650	COG1940	carbohydrate kinase activity
H4W23_RS31660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4W23_RS31700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS31705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H4W23_RS31720	COG1126	abc transporter atp-binding protein
H4W23_RS31725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS31730	COG0765	amino acid transport
H4W23_RS31735	COG0765	amino acid transport
H4W23_RS31760	COG0405	Gamma-glutamyltransferase
H4W23_RS31805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4W23_RS31845	COG0483	inositol monophosphate 1-phosphatase activity
H4W23_RS31855	COG0009	L-threonylcarbamoyladenylate synthase
H4W23_RS31860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4W23_RS31870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4W23_RS31875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4W23_RS31895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4W23_RS31900	COG1929	Belongs to the glycerate kinase type-1 family
H4W23_RS31920	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS31925	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS31950	COG0688	phosphatidylethanolamine metabolic process
H4W23_RS31955	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS31970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS31970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W23_RS31975	COG0604	alcohol dehydrogenase
H4W23_RS31985	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS32005	COG0477	Major facilitator Superfamily
H4W23_RS32035	COG2362	D-Aminopeptidase
H4W23_RS32040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4W23_RS32045	COG0823	Involved in the tonB-independent uptake of proteins
H4W23_RS32045	COG1506	peptidase
H4W23_RS32045	COG4946	Tricorn protease homolog
H4W23_RS32050	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4W23_RS32055	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4W23_RS32100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4W23_RS32110	COG2226	methyltransferase
H4W23_RS32185	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4W23_RS32195	COG2378	regulation of single-species biofilm formation
H4W23_RS32200	COG0702	epimerase
H4W23_RS32210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H4W23_RS32220	COG0656	L-ascorbic acid biosynthetic process
H4W23_RS32255	COG1335	isochorismatase
H4W23_RS32270	COG0789	Transcriptional regulator
H4W23_RS32275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4W23_RS32280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W23_RS32300	COG1129	ABC transporter
H4W23_RS32305	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4W23_RS32315	COG0673	inositol 2-dehydrogenase activity
H4W23_RS32375	COG2824	Alkylphosphonate utilization operon protein PhnA
H4W23_RS32415	COG1486	melibiose metabolic process
H4W23_RS32420	COG3012	SEC-C Motif Domain Protein
H4W23_RS32435	COG1793	dna ligase
H4W23_RS32475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4W23_RS32480	COG1116	anion transmembrane transporter activity
H4W23_RS32485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4W23_RS32490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS32520	COG0488	(ABC) transporter
H4W23_RS32545	COG1515	deoxyribonuclease V activity
H4W23_RS32555	COG3268	Saccharopine dehydrogenase
H4W23_RS32560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W23_RS32565	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS32570	COG0183	Belongs to the thiolase family
H4W23_RS32575	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS32575	COG1024	Enoyl-CoA hydratase
H4W23_RS32600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4W23_RS32615	COG2936	dipeptidyl-peptidase activity
H4W23_RS32640	COG0488	(ABC) transporter
H4W23_RS32655	COG2183	response to ionizing radiation
H4W23_RS32665	COG4977	sequence-specific DNA binding
H4W23_RS32675	COG1024	Enoyl-CoA hydratase
H4W23_RS32685	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H4W23_RS32730	COG1388	LysM domain
H4W23_RS32730	COG1134	teichoic acid transport
H4W23_RS32740	COG1562	ergosterol biosynthetic process
H4W23_RS32755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H4W23_RS32765	COG1657	PFAM Prenyltransferase squalene oxidase
H4W23_RS32795	COG2365	Tyrosine phosphatase family
H4W23_RS32800	COG0739	heme binding
H4W23_RS32805	COG2755	lipolytic protein G-D-S-L family
H4W23_RS32815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4W23_RS32855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4W23_RS32900	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS32910	COG0673	inositol 2-dehydrogenase activity
H4W23_RS32925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W23_RS32930	COG1105	Belongs to the carbohydrate kinase PfkB family
H4W23_RS32935	COG1940	carbohydrate kinase activity
H4W23_RS32940	COG1349	DNA-binding transcription factor activity
H4W23_RS32955	COG0395	ABC-type sugar transport system, permease component
H4W23_RS32980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4W23_RS32985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4W23_RS32990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4W23_RS33005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4W23_RS33015	COG0142	geranyltranstransferase activity
H4W23_RS33025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4W23_RS33060	COG1864	DNA RNA non-specific endonuclease
H4W23_RS33060	COG3591	Belongs to the peptidase S1B family
H4W23_RS33075	COG1404	Belongs to the peptidase S8 family
H4W23_RS33115	COG3189	MarR family transcriptional regulator
H4W23_RS33125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H4W23_RS33145	COG2175	clavaminate synthase activity
H4W23_RS33160	COG0300	oxidoreductase activity
H4W23_RS33190	COG0494	nUDIX hydrolase
H4W23_RS33215	COG1940	carbohydrate kinase activity
H4W23_RS33220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W23_RS33225	COG0395	ABC-type sugar transport system, permease component
H4W23_RS33245	COG1609	Transcriptional regulator
H4W23_RS33250	COG1609	Transcriptional regulator
H4W23_RS33320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H4W23_RS33330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4W23_RS33335	COG2211	Major facilitator Superfamily
H4W23_RS33355	COG4865	methylaspartate mutase activity
H4W23_RS33370	COG0644	oxidoreductase
H4W23_RS33395	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4W23_RS33400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H4W23_RS33425	COG2197	response regulator
H4W23_RS33425	COG3903	Transcriptional regulator
H4W23_RS33460	COG1846	Transcriptional regulator
H4W23_RS33470	COG2353	YceI-like domain
H4W23_RS33490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4W23_RS33505	COG2264	protein methyltransferase activity
H4W23_RS33515	COG0514	ATP-dependent DNA helicase (RecQ)
H4W23_RS33520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4W23_RS33530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4W23_RS33545	COG0584	glycerophosphoryl diester phosphodiesterase
H4W23_RS33550	COG0789	Transcriptional regulator
H4W23_RS33565	COG0395	ABC-type sugar transport system, permease component
H4W23_RS33570	COG1175	transmembrane transport
H4W23_RS33585	COG5297	Belongs to the glycosyl hydrolase family 6
H4W23_RS33595	COG5297	Belongs to the glycosyl hydrolase family 6
H4W23_RS33595	COG4733	cellulase activity
H4W23_RS33605	COG1653	transport
H4W23_RS33610	COG1175	transmembrane transport
H4W23_RS33615	COG0395	ABC-type sugar transport system, permease component
H4W23_RS33645	COG1595	DNA-templated transcription, initiation
H4W23_RS33665	COG1695	Transcriptional regulator
H4W23_RS33685	COG4677	pectinesterase activity
H4W23_RS33690	COG3866	Pectate lyase
H4W23_RS33695	COG2755	lipolytic protein G-D-S-L family
H4W23_RS33700	COG1653	transport
H4W23_RS33705	COG3507	Belongs to the glycosyl hydrolase 43 family
H4W23_RS33720	COG0395	ABC-type sugar transport system, permease component
H4W23_RS33740	COG1802	Transcriptional regulator
H4W23_RS33745	COG1501	Belongs to the glycosyl hydrolase 31 family
H4W23_RS33795	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W23_RS33805	COG4209	transmembrane transport
H4W23_RS33810	COG0395	ABC-type sugar transport system, permease component
H4W23_RS33825	COG1609	Transcriptional regulator
H4W23_RS33850	COG1414	Transcriptional regulator
H4W23_RS33855	COG1940	carbohydrate kinase activity
H4W23_RS33865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4W23_RS33895	COG1175	transmembrane transport
H4W23_RS33900	COG0395	ABC-type sugar transport system, permease component
H4W23_RS33910	COG1556	Lactate utilization protein
H4W23_RS33915	COG1139	Iron-sulfur cluster binding protein
H4W23_RS33920	COG0247	lactate metabolic process
H4W23_RS33925	COG1070	Carbohydrate kinase
H4W23_RS33930	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS33930	COG3347	Dehydrogenase
H4W23_RS33940	COG3254	rhamnose metabolic process
H4W23_RS33945	COG1609	Transcriptional regulator
H4W23_RS34020	COG1136	(ABC) transporter
H4W23_RS34075	COG2124	cytochrome p450
H4W23_RS34085	COG3458	cephalosporin-C deacetylase activity
H4W23_RS34110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4W23_RS34180	COG2826	transposase and inactivated derivatives, IS30 family
H4W23_RS34195	COG3220	belongs to the UPF0276 family
H4W23_RS34250	COG0515	serine threonine protein kinase
H4W23_RS34340	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H4W23_RS34350	COG4948	Mandelate Racemase Muconate Lactonizing
H4W23_RS34355	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS34370	COG3386	PFAM SMP-30 Gluconolaconase
H4W23_RS34430	COG0667	Aldo Keto reductase
H4W23_RS34435	COG1132	(ABC) transporter
H4W23_RS34440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS34445	COG1116	anion transmembrane transporter activity
H4W23_RS34450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4W23_RS34460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS34470	COG2175	clavaminate synthase activity
H4W23_RS34490	COG0277	FAD linked oxidase domain protein
H4W23_RS34535	COG2326	polyphosphate kinase activity
H4W23_RS34550	COG1136	(ABC) transporter
H4W23_RS34550	COG0577	efflux transmembrane transporter activity
H4W23_RS34555	COG1136	(ABC) transporter
H4W23_RS34580	COG0659	secondary active sulfate transmembrane transporter activity
H4W23_RS34590	COG2824	Alkylphosphonate utilization operon protein PhnA
H4W23_RS34605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4W23_RS34615	COG1937	Protein conserved in bacteria
H4W23_RS34635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4W23_RS34640	COG3383	formate dehydrogenase (NAD+) activity
H4W23_RS34650	COG2239	Acts as a magnesium transporter
H4W23_RS34660	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS34665	COG0022	dehydrogenase e1 component
H4W23_RS34665	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W23_RS34670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4W23_RS34675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4W23_RS34680	COG0516	GMP reductase activity
H4W23_RS34680	COG0517	IMP dehydrogenase activity
H4W23_RS34690	COG2239	Acts as a magnesium transporter
H4W23_RS34710	COG2217	Heavy metal translocating P-type atpase
H4W23_RS34730	COG0574	Belongs to the PEP-utilizing enzyme family
H4W23_RS34730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4W23_RS34740	COG0071	Belongs to the small heat shock protein (HSP20) family
H4W23_RS34755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4W23_RS34765	COG2239	Acts as a magnesium transporter
H4W23_RS34780	COG0517	IMP dehydrogenase activity
H4W23_RS34780	COG0516	GMP reductase activity
H4W23_RS34785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4W23_RS34790	COG1063	alcohol dehydrogenase
H4W23_RS34795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W23_RS34840	COG0516	GMP reductase activity
H4W23_RS34840	COG0517	IMP dehydrogenase activity
H4W23_RS34885	COG4122	O-methyltransferase activity
H4W23_RS34915	COG0297	glycogen (starch) synthase activity
H4W23_RS34935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4W23_RS34975	COG2268	Band 7 protein
H4W23_RS34980	COG1585	Membrane protein implicated in regulation of membrane protease activity
H4W23_RS34990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4W23_RS34995	COG0569	domain protein
H4W23_RS35015	COG1131	(ABC) transporter
H4W23_RS35045	COG2255	four-way junction helicase activity
H4W23_RS35055	COG1115	amino acid carrier protein
H4W23_RS35060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4W23_RS35150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H4W23_RS35180	COG0745	RESPONSE REGULATOR receiver
H4W23_RS35185	COG2205	protein histidine kinase activity
H4W23_RS35340	COG0305	Participates in initiation and elongation during chromosome replication
H4W23_RS35430	COG1074	ATP-dependent DNA helicase activity
H4W23_RS35460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4W23_RS35520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4W23_RS35535	COG0745	RESPONSE REGULATOR receiver
H4W23_RS35550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4W23_RS35565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4W23_RS35570	COG3275	phosphorelay sensor kinase activity
H4W23_RS35650	COG1053	succinate dehydrogenase
H4W23_RS35655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4W23_RS35695	COG2182	Extracellular solute-binding protein
H4W23_RS35710	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H4W23_RS35715	COG0121	glutamine amidotransferase
H4W23_RS35720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4W23_RS35740	COG2268	Band 7 protein
H4W23_RS35760	COG1609	Transcriptional regulator
H4W23_RS35770	COG0183	Belongs to the thiolase family
H4W23_RS35775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4W23_RS35780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4W23_RS35835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4W23_RS35850	COG2890	protein-(glutamine-N5) methyltransferase activity
H4W23_RS35860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4W23_RS35905	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W23_RS35915	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS35935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4W23_RS35960	COG1506	peptidase
H4W23_RS35960	COG0823	Involved in the tonB-independent uptake of proteins
H4W23_RS35970	COG0431	NADPH-dependent FMN reductase
H4W23_RS36010	COG2124	cytochrome p450
H4W23_RS36110	COG4865	methylaspartate mutase activity
H4W23_RS36115	COG0017	Asparaginyl-tRNA synthetase
H4W23_RS36120	COG0069	glutamate synthase activity
H4W23_RS36130	COG0154	amidase activity
H4W23_RS36135	COG3251	PFAM MbtH domain protein
H4W23_RS36145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4W23_RS36155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4W23_RS36160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4W23_RS36170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4W23_RS36185	COG3903	Transcriptional regulator
H4W23_RS36185	COG3629	intracellular signal transduction
H4W23_RS36200	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS36205	COG2124	cytochrome p450
H4W23_RS36215	COG3629	intracellular signal transduction
H4W23_RS36215	COG3903	Transcriptional regulator
H4W23_RS36260	COG3321	synthase
H4W23_RS36260	COG0604	alcohol dehydrogenase
H4W23_RS36260	COG3321	synthase
H4W23_RS36260	COG0604	alcohol dehydrogenase
H4W23_RS36295	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H4W23_RS36300	COG0714	Associated with various cellular activities
H4W23_RS36310	COG2045	Belongs to the ComB family
H4W23_RS36360	COG1278	Cold shock
H4W23_RS36365	COG0513	Belongs to the DEAD box helicase family
H4W23_RS36390	COG1720	tRNA m6t6A37 methyltransferase activity
H4W23_RS36400	COG2205	protein histidine kinase activity
H4W23_RS36415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4W23_RS36415	COG0825	malonyl-CoA metabolic process
H4W23_RS36450	COG1126	abc transporter atp-binding protein
H4W23_RS36455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W23_RS36460	COG0765	amino acid transport
H4W23_RS36465	COG0765	amino acid transport
H4W23_RS36485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4W23_RS36495	COG1174	glycine betaine transport
H4W23_RS36500	COG1174	glycine betaine transport
H4W23_RS36525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W23_RS36545	COG0492	ferredoxin-NADP+ reductase activity
H4W23_RS36560	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS36565	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS36575	COG0601	transmembrane transport
H4W23_RS36580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS36585	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS36625	COG3387	PFAM Glycoside hydrolase 15-related
H4W23_RS36640	COG1271	oxidase subunit
H4W23_RS36645	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS36660	COG3265	gluconokinase activity
H4W23_RS36670	COG2271	Major facilitator Superfamily
H4W23_RS36725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4W23_RS36735	COG2226	methyltransferase
H4W23_RS36770	COG4974	Belongs to the 'phage' integrase family
H4W23_RS36830	COG0366	Alpha amylase catalytic
H4W23_RS36830	COG1874	Beta-galactosidase
H4W23_RS36850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4W23_RS36855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4W23_RS36855	COG1116	anion transmembrane transporter activity
H4W23_RS36865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4W23_RS36875	COG2188	Transcriptional regulator
H4W23_RS36895	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS36900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4W23_RS36910	COG0747	negative chemotaxis
H4W23_RS36915	COG1609	Transcriptional regulator
H4W23_RS36950	COG3250	beta-galactosidase activity
H4W23_RS36955	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
H4W23_RS36975	COG0395	ABC-type sugar transport system, permease component
H4W23_RS36980	COG1175	transmembrane transport
H4W23_RS37000	COG0402	S-adenosylhomocysteine deaminase activity
H4W23_RS37005	COG1802	Transcriptional regulator
H4W23_RS37020	COG0395	ABC-type sugar transport system, permease component
H4W23_RS37030	COG1653	transport
H4W23_RS37040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4W23_RS37065	COG0243	molybdopterin cofactor binding
H4W23_RS37075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4W23_RS37085	COG4214	carbohydrate transport
H4W23_RS37095	COG4213	ABC transporter substrate-binding protein
H4W23_RS37100	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS37155	COG1414	Transcriptional regulator
H4W23_RS37170	COG0183	Belongs to the thiolase family
H4W23_RS37175	COG3485	protocatechuate 3,4-dioxygenase
H4W23_RS37180	COG3485	protocatechuate 3,4-dioxygenase
H4W23_RS37185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS37195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W23_RS37205	COG4585	Histidine kinase
H4W23_RS37215	COG0659	secondary active sulfate transmembrane transporter activity
H4W23_RS37220	COG1231	oxidoreductase activity
H4W23_RS37225	COG3973	AAA domain
H4W23_RS37230	COG1846	Transcriptional regulator
H4W23_RS37270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4W23_RS37275	COG1653	transport
H4W23_RS37285	COG0395	ABC-type sugar transport system, permease component
H4W23_RS37365	COG0583	DNA-binding transcription factor activity
H4W23_RS37395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W23_RS37410	COG1309	transcriptional regulator
H4W23_RS37420	COG2205	protein histidine kinase activity
H4W23_RS37425	COG0745	RESPONSE REGULATOR receiver
H4W23_RS37440	COG1136	(ABC) transporter
H4W23_RS37440	COG0577	efflux transmembrane transporter activity
H4W23_RS37445	COG0577	efflux transmembrane transporter activity
H4W23_RS37445	COG1136	(ABC) transporter
H4W23_RS37450	COG0832	Belongs to the urease beta subunit family
H4W23_RS37450	COG0831	urea catabolic process
H4W23_RS37455	COG0804	urea catabolic process
H4W23_RS37465	COG0747	negative chemotaxis
H4W23_RS37480	COG0444	Belongs to the ABC transporter superfamily
H4W23_RS37485	COG4608	Belongs to the ABC transporter superfamily
H4W23_RS37495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4W23_RS37515	COG0308	aminopeptidase N
H4W23_RS37530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4W23_RS37540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W23_RS37550	COG1309	transcriptional regulator
H4W23_RS37560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H4W23_RS37560	COG1672	PFAM Archaeal ATPase
H4W23_RS37570	COG0154	amidase activity
H4W23_RS37575	COG1428	Deoxynucleoside kinase
H4W23_RS37585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4W23_RS37600	COG1215	transferase activity, transferring glycosyl groups
H4W23_RS37610	COG4310	Domain of unknown function (DUF2172)
H4W23_RS37620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4W23_RS37625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4W23_RS37635	COG0438	transferase activity, transferring glycosyl groups
H4W23_RS37680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4W23_RS37685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4W23_RS37700	COG2226	methyltransferase
H4W23_RS37710	COG4981	capsule polysaccharide biosynthetic process
H4W23_RS37745	COG1073	alpha beta
H4W23_RS37750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4W23_RS37765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4W23_RS37770	COG3239	Fatty acid desaturase
H4W23_RS37820	COG2018	Roadblock/LC7 domain
H4W23_RS37830	COG1793	dna ligase
H4W23_RS37840	COG0726	polysaccharide deacetylase
H4W23_RS37860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4W23_RS37860	COG1017	nitric oxide dioxygenase activity
H4W23_RS37865	COG1959	2 iron, 2 sulfur cluster binding
H4W23_RS37900	COG1376	ErfK ybiS ycfS ynhG family protein
H4W23_RS37920	COG2814	Major facilitator Superfamily
H4W23_RS37925	COG0583	DNA-binding transcription factor activity
H4W23_RS37930	COG1473	amidohydrolase
H4W23_RS37945	COG0477	Major facilitator Superfamily
H4W23_RS37960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS37965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W23_RS37975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4W23_RS37985	COG0542	response to heat
H4W23_RS38025	COG4585	Histidine kinase
H4W23_RS38030	COG2197	response regulator
H4W23_RS38035	COG1051	belongs to the nudix hydrolase family
H4W23_RS38060	COG0702	epimerase
H4W23_RS38065	COG0254	rRNA binding
H4W23_RS38080	COG0589	response to stress
H4W23_RS38105	COG3511	phospholipase C
H4W23_RS38115	COG1349	DNA-binding transcription factor activity
H4W23_RS38140	COG4977	sequence-specific DNA binding
H4W23_RS38160	COG2205	protein histidine kinase activity
H4W23_RS38165	COG0745	RESPONSE REGULATOR receiver
H4W23_RS38180	COG0577	efflux transmembrane transporter activity
H4W23_RS38180	COG1136	(ABC) transporter
H4W23_RS38185	COG1136	(ABC) transporter
H4W23_RS38185	COG0577	efflux transmembrane transporter activity
H4W23_RS38300	COG2197	response regulator
H4W23_RS38305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W23_RS38310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4W23_RS38320	COG0477	Major facilitator Superfamily
H4W23_RS38350	COG1902	pentaerythritol trinitrate reductase activity
H4W23_RS38360	COG0154	amidase activity
H4W23_RS38425	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS38430	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS38435	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS38440	COG1024	Enoyl-CoA hydratase
H4W23_RS38445	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS38455	COG1309	transcriptional regulator
H4W23_RS38460	COG0183	Belongs to the thiolase family
H4W23_RS38485	COG1024	Enoyl-CoA hydratase
H4W23_RS38495	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS38500	COG3971	2-oxopent-4-enoate hydratase activity
H4W23_RS38510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4W23_RS38540	COG1414	Transcriptional regulator
H4W23_RS38550	COG1960	acyl-CoA dehydrogenase activity
H4W23_RS38565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4W23_RS38570	COG1053	succinate dehydrogenase
H4W23_RS38585	COG2072	flavoprotein involved in K transport
H4W23_RS38590	COG0318	PFAM AMP-dependent synthetase and ligase
H4W23_RS38595	COG0666	response to abiotic stimulus
H4W23_RS38620	COG0723	plastoquinol--plastocyanin reductase activity
H4W23_RS38620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W23_RS38625	COG0697	spore germination
H4W23_RS38650	COG1476	TRANSCRIPTIONal
H4W23_RS38685	COG1595	DNA-templated transcription, initiation
H4W23_RS38690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS38700	COG3655	Transcriptional regulator
H4W23_RS38735	COG3795	YCII-related domain
H4W23_RS38755	COG3629	intracellular signal transduction
H4W23_RS38765	COG4585	Histidine kinase
H4W23_RS38770	COG2409	Drug exporters of the RND superfamily
H4W23_RS38825	COG1028	Short-chain dehydrogenase reductase Sdr
H4W23_RS38855	COG2205	protein histidine kinase activity
H4W23_RS38860	COG0745	RESPONSE REGULATOR receiver
H4W23_RS38870	COG1132	(ABC) transporter
H4W23_RS38925	COG1653	transport
H4W23_RS38930	COG1175	transmembrane transport
H4W23_RS38935	COG0395	ABC-type sugar transport system, permease component
H4W23_RS38940	COG0366	Alpha amylase catalytic
H4W23_RS38990	COG2340	Cysteine-rich secretory protein family
H4W23_RS39005	COG2197	response regulator
H4W23_RS39020	COG0702	epimerase
H4W23_RS39045	COG1716	ATPase activity
H4W23_RS39055	COG3119	arylsulfatase activity
H4W23_RS39065	COG0702	epimerase
H4W23_RS39095	COG3708	Transcriptional regulator
H4W23_RS39095	COG2207	Transcriptional regulator
H4W23_RS39155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4W23_RS39175	COG0148	phosphopyruvate hydratase activity
H4W23_RS39220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H4W23_RS39295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4W23_RS39320	COG1401	restriction endodeoxyribonuclease activity
H4W23_RS39410	COG0596	Alpha beta hydrolase
H4W23_RS39445	COG2964	Protein conserved in bacteria
H4W23_RS39450	COG2814	Major facilitator Superfamily
H4W23_RS39480	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W23_RS39605	COG2813	Specifically methylates the guanine in position
H4W23_RS39710	COG3293	Transposase
H4W23_RS39715	COG0539	negative regulation of cytoplasmic translation
H4W23_RS39805	COG1408	metallophosphoesterase
H4W23_RS39810	COG1309	transcriptional regulator
H4W23_RS39815	COG0277	FAD linked oxidase domain protein
H4W23_RS39900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W23_RS39920	COG2205	protein histidine kinase activity
H4W23_RS39930	COG0785	Cytochrome C biogenesis protein
H4W23_RS39935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4W23_RS39955	COG0745	RESPONSE REGULATOR receiver
H4W23_RS39970	COG2205	protein histidine kinase activity
H4W23_RS39975	COG0745	RESPONSE REGULATOR receiver
H4W23_RS40015	COG1846	Transcriptional regulator
H4W23_RS40020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4W23_RS40060	COG0667	Aldo Keto reductase
H4W23_RS40085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W23_RS40220	COG2226	methyltransferase
H4W23_RS40280	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4W23_RS40455	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H4W23_RS40455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate