locus-tag	class	description
B1H19_RS00025	COG2124	cytochrome p450
B1H19_RS00030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS00045	COG1522	sequence-specific DNA binding
B1H19_RS00070	COG0477	Major facilitator Superfamily
B1H19_RS00100	COG0494	nUDIX hydrolase
B1H19_RS00130	COG0583	DNA-binding transcription factor activity
B1H19_RS00230	COG2910	NAD(P)H-binding
B1H19_RS00310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1H19_RS00315	COG0667	Aldo Keto reductase
B1H19_RS00330	COG3979	chitinase
B1H19_RS00355	COG0110	maltose O-acetyltransferase activity
B1H19_RS00360	COG4257	antibiotic catabolic process
B1H19_RS00365	COG3795	YCII-related domain
B1H19_RS00385	COG0740	serine-type endopeptidase activity
B1H19_RS00390	COG0740	serine-type endopeptidase activity
B1H19_RS00410	COG1116	anion transmembrane transporter activity
B1H19_RS00440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1H19_RS00480	COG0640	Transcriptional regulator
B1H19_RS00495	COG0305	Participates in initiation and elongation during chromosome replication
B1H19_RS00495	COG1372	Participates in initiation and elongation during chromosome replication
B1H19_RS00515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B1H19_RS00530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1H19_RS00560	COG2318	DinB family
B1H19_RS00595	COG0730	response to heat
B1H19_RS00600	COG1937	Protein conserved in bacteria
B1H19_RS00640	COG4585	Histidine kinase
B1H19_RS00675	COG0243	molybdopterin cofactor binding
B1H19_RS00700	COG1609	Transcriptional regulator
B1H19_RS00720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1H19_RS00785	COG1309	transcriptional regulator
B1H19_RS00795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1H19_RS00840	COG0726	polysaccharide deacetylase
B1H19_RS00845	COG0586	Pfam SNARE associated Golgi protein
B1H19_RS00865	COG1278	Cold shock
B1H19_RS00875	COG0604	alcohol dehydrogenase
B1H19_RS00875	COG3321	synthase
B1H19_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS00945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1H19_RS01010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B1H19_RS01040	COG0148	phosphopyruvate hydratase activity
B1H19_RS01095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS01120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1H19_RS01140	COG0626	cystathionine gamma-synthase activity
B1H19_RS01145	COG3328	transposase activity
B1H19_RS01150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1H19_RS01165	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS01240	COG1309	transcriptional regulator
B1H19_RS01245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B1H19_RS01250	COG2409	Drug exporters of the RND superfamily
B1H19_RS01260	COG0789	Transcriptional regulator
B1H19_RS01340	COG2070	2-Nitropropane dioxygenase
B1H19_RS01340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1H19_RS01370	COG1819	glycosyl
B1H19_RS01380	COG0805	protein transport
B1H19_RS01415	COG3794	PFAM blue (type 1) copper domain protein
B1H19_RS01450	COG3618	amidohydrolase
B1H19_RS01460	COG1556	Lactate utilization protein
B1H19_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS01475	COG4948	Mandelate Racemase Muconate Lactonizing
B1H19_RS01480	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1H19_RS01490	COG1129	ABC transporter
B1H19_RS01495	COG1879	ABC-type sugar transport system periplasmic component
B1H19_RS01500	COG2186	Transcriptional regulator
B1H19_RS01510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS01520	COG2319	Wd-40 repeat
B1H19_RS01520	COG4249	Peptidase C14 caspase catalytic subunit p20
B1H19_RS01540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1H19_RS01570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1H19_RS01630	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1H19_RS01670	COG2226	methyltransferase
B1H19_RS01705	COG4221	oxidoreductase activity
B1H19_RS01710	COG0596	Alpha beta hydrolase
B1H19_RS01740	COG4257	antibiotic catabolic process
B1H19_RS01760	COG4941	Belongs to the sigma-70 factor family
B1H19_RS01765	COG3795	YCII-related domain
B1H19_RS01795	COG1132	(ABC) transporter
B1H19_RS01810	COG4978	Transcriptional regulator
B1H19_RS01810	COG0789	Transcriptional regulator
B1H19_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS01870	COG2030	dehydratase
B1H19_RS01905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B1H19_RS01945	COG4977	sequence-specific DNA binding
B1H19_RS01970	COG2267	carboxylic ester hydrolase activity
B1H19_RS02020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1H19_RS02030	COG3973	AAA domain
B1H19_RS02040	COG0300	oxidoreductase activity
B1H19_RS02070	COG0431	NADPH-dependent FMN reductase
B1H19_RS02110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1H19_RS02130	COG1794	racemase activity, acting on amino acids and derivatives
B1H19_RS02170	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS02190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1H19_RS02245	COG3321	synthase
B1H19_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS02245	COG0604	alcohol dehydrogenase
B1H19_RS02260	COG0330	HflC and HflK could
B1H19_RS02305	COG0531	amino acid
B1H19_RS02330	COG2272	Belongs to the type-B carboxylesterase lipase family
B1H19_RS02335	COG3226	Transcriptional regulator
B1H19_RS02350	COG1011	Hydrolase
B1H19_RS02355	COG2972	Histidine kinase
B1H19_RS02360	COG0142	geranyltranstransferase activity
B1H19_RS02370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1H19_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS02455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1H19_RS02460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1H19_RS02465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1H19_RS02470	COG0254	rRNA binding
B1H19_RS02480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1H19_RS02505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1H19_RS02515	COG1051	belongs to the nudix hydrolase family
B1H19_RS02530	COG0463	Glycosyl transferase, family 2
B1H19_RS02630	COG3158	transport of potassium into the cell
B1H19_RS02700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1H19_RS02705	COG0531	amino acid
B1H19_RS02740	COG0657	acetylesterase activity
B1H19_RS02745	COG2409	Drug exporters of the RND superfamily
B1H19_RS02755	COG0076	glutamate decarboxylase activity
B1H19_RS02775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1H19_RS02780	COG0142	geranyltranstransferase activity
B1H19_RS02785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1H19_RS02845	COG2124	cytochrome p450
B1H19_RS02925	COG3842	ATPase activity
B1H19_RS02945	COG2188	Transcriptional regulator
B1H19_RS02995	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS03030	COG5285	phytanoyl-CoA dioxygenase
B1H19_RS03050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1H19_RS03060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1H19_RS03065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1H19_RS03070	COG2274	protein secretion by the type I secretion system
B1H19_RS03085	COG3851	Histidine kinase
B1H19_RS03090	COG2197	response regulator
B1H19_RS03100	COG1131	(ABC) transporter
B1H19_RS03155	COG2018	Roadblock/LC7 domain
B1H19_RS03165	COG2223	nitrite transmembrane transporter activity
B1H19_RS03175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1H19_RS03185	COG0765	amino acid transport
B1H19_RS03190	COG1126	abc transporter atp-binding protein
B1H19_RS03205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1H19_RS03210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS03215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS03220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS03235	COG0513	Belongs to the DEAD box helicase family
B1H19_RS03245	COG1027	Aspartate ammonia-lyase
B1H19_RS03250	COG2226	methyltransferase
B1H19_RS03260	COG1984	allophanate hydrolase subunit 2
B1H19_RS03275	COG0784	Response regulator, receiver
B1H19_RS03275	COG5002	protein histidine kinase activity
B1H19_RS03275	COG2205	protein histidine kinase activity
B1H19_RS03280	COG0745	RESPONSE REGULATOR receiver
B1H19_RS03300	COG2124	cytochrome p450
B1H19_RS03320	COG2124	cytochrome p450
B1H19_RS03330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1H19_RS03350	COG2205	protein histidine kinase activity
B1H19_RS03365	COG0483	inositol monophosphate 1-phosphatase activity
B1H19_RS03375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1H19_RS03390	COG2205	protein histidine kinase activity
B1H19_RS03410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B1H19_RS03435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B1H19_RS03440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1H19_RS03460	COG2132	Multicopper oxidase
B1H19_RS03465	COG0531	amino acid
B1H19_RS03475	COG0589	response to stress
B1H19_RS03480	COG4109	DRTGG domain
B1H19_RS03495	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B1H19_RS03500	COG0215	cysteine-tRNA ligase activity
B1H19_RS03525	COG1309	transcriptional regulator
B1H19_RS03540	COG0516	GMP reductase activity
B1H19_RS03540	COG0517	IMP dehydrogenase activity
B1H19_RS03555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1H19_RS03585	COG0516	GMP reductase activity
B1H19_RS03585	COG0517	IMP dehydrogenase activity
B1H19_RS03630	COG0516	GMP reductase activity
B1H19_RS03630	COG0517	IMP dehydrogenase activity
B1H19_RS03645	COG1231	oxidoreductase activity
B1H19_RS03655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1H19_RS03690	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B1H19_RS03720	COG0569	domain protein
B1H19_RS03725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1H19_RS03740	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1H19_RS03745	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1H19_RS03745	COG0022	dehydrogenase e1 component
B1H19_RS03750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B1H19_RS03755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1H19_RS03765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1H19_RS03800	COG0517	IMP dehydrogenase activity
B1H19_RS03800	COG0516	GMP reductase activity
B1H19_RS03810	COG0589	response to stress
B1H19_RS03835	COG1136	(ABC) transporter
B1H19_RS03835	COG0577	efflux transmembrane transporter activity
B1H19_RS03840	COG0577	efflux transmembrane transporter activity
B1H19_RS03840	COG1136	(ABC) transporter
B1H19_RS03845	COG2197	response regulator
B1H19_RS03850	COG4585	Histidine kinase
B1H19_RS03860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1H19_RS03860	COG0463	Glycosyl transferase, family 2
B1H19_RS03900	COG1082	Xylose isomerase domain protein TIM barrel
B1H19_RS03915	COG3961	Belongs to the TPP enzyme family
B1H19_RS03945	COG1116	anion transmembrane transporter activity
B1H19_RS03950	COG0640	Transcriptional regulator
B1H19_RS03955	COG0598	Magnesium transport protein CorA
B1H19_RS03960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1H19_RS04015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1H19_RS04090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1H19_RS04095	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS04140	COG2197	response regulator
B1H19_RS04175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1H19_RS04180	COG0367	asparagine synthase
B1H19_RS04190	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS04195	COG1733	regulation of RNA biosynthetic process
B1H19_RS04200	COG0702	epimerase
B1H19_RS04260	COG4264	IucA IucC family
B1H19_RS04270	COG2018	Roadblock/LC7 domain
B1H19_RS04300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B1H19_RS04305	COG1522	sequence-specific DNA binding
B1H19_RS04365	COG0667	Aldo Keto reductase
B1H19_RS04405	COG0583	DNA-binding transcription factor activity
B1H19_RS04425	COG0596	Alpha beta hydrolase
B1H19_RS04465	COG0028	Belongs to the TPP enzyme family
B1H19_RS04490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1H19_RS04510	COG0367	asparagine synthase
B1H19_RS04545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1H19_RS04560	COG4310	Domain of unknown function (DUF2172)
B1H19_RS04570	COG1215	transferase activity, transferring glycosyl groups
B1H19_RS04585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1H19_RS04605	COG0574	Belongs to the PEP-utilizing enzyme family
B1H19_RS04605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1H19_RS04610	COG0151	Belongs to the GarS family
B1H19_RS04625	COG1414	Transcriptional regulator
B1H19_RS04630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1H19_RS04635	COG0494	nUDIX hydrolase
B1H19_RS04640	COG1132	(ABC) transporter
B1H19_RS04715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS04740	COG0154	amidase activity
B1H19_RS04760	COG0137	argininosuccinate synthase activity
B1H19_RS04780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS04780	COG2080	2 iron, 2 sulfur cluster binding
B1H19_RS04845	COG2272	Belongs to the type-B carboxylesterase lipase family
B1H19_RS04855	COG2197	response regulator
B1H19_RS04870	COG3469	chitinase activity
B1H19_RS04875	COG0069	glutamate synthase activity
B1H19_RS04885	COG2267	carboxylic ester hydrolase activity
B1H19_RS04900	COG0346	lactoylglutathione lyase activity
B1H19_RS04960	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS04995	COG0745	RESPONSE REGULATOR receiver
B1H19_RS05000	COG2205	protein histidine kinase activity
B1H19_RS05010	COG3629	intracellular signal transduction
B1H19_RS05020	COG3321	synthase
B1H19_RS05020	COG0604	alcohol dehydrogenase
B1H19_RS05060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1H19_RS05075	COG0604	alcohol dehydrogenase
B1H19_RS05075	COG3321	synthase
B1H19_RS05085	COG0604	alcohol dehydrogenase
B1H19_RS05085	COG3321	synthase
B1H19_RS05100	COG0235	Class ii aldolase
B1H19_RS05120	COG1280	lysine exporter protein (LysE YggA)
B1H19_RS05150	COG0019	diaminopimelate decarboxylase activity
B1H19_RS05165	COG0745	RESPONSE REGULATOR receiver
B1H19_RS05170	COG5000	phosphorelay sensor kinase activity
B1H19_RS05170	COG5002	protein histidine kinase activity
B1H19_RS05240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1H19_RS05245	COG3170	Tfp pilus assembly protein FimV
B1H19_RS05250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS05265	COG3594	Acyltransferase
B1H19_RS05280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B1H19_RS05290	COG2124	cytochrome p450
B1H19_RS05325	COG3209	COG3209 Rhs family protein
B1H19_RS05395	COG4974	Belongs to the 'phage' integrase family
B1H19_RS05425	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1H19_RS05500	COG0492	ferredoxin-NADP+ reductase activity
B1H19_RS05515	COG2755	lipolytic protein G-D-S-L family
B1H19_RS05535	COG1017	nitric oxide dioxygenase activity
B1H19_RS05535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1H19_RS05545	COG0477	Major facilitator Superfamily
B1H19_RS05570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1H19_RS05595	COG1090	epimerase
B1H19_RS05615	COG4044	May play a role in the intracellular transport of hydrophobic ligands
B1H19_RS05625	COG0667	Aldo Keto reductase
B1H19_RS05715	COG1846	Transcriptional regulator
B1H19_RS05715	COG0456	acetyltransferase
B1H19_RS05720	COG2226	methyltransferase
B1H19_RS05730	COG0477	Major facilitator Superfamily
B1H19_RS05755	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1H19_RS05785	COG1597	lipid kinase activity
B1H19_RS05825	COG1618	nucleotide phosphatase activity, acting on free nucleotides
B1H19_RS05860	COG2018	Roadblock/LC7 domain
B1H19_RS05900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1H19_RS05900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1H19_RS05930	COG0702	epimerase
B1H19_RS05955	COG3511	phospholipase C
B1H19_RS05970	COG0673	inositol 2-dehydrogenase activity
B1H19_RS06010	COG2124	cytochrome p450
B1H19_RS06015	COG2135	peptidase activity
B1H19_RS06025	COG0531	amino acid
B1H19_RS06035	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS06050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1H19_RS06080	COG1414	Transcriptional regulator
B1H19_RS06090	COG2205	protein histidine kinase activity
B1H19_RS06095	COG0745	RESPONSE REGULATOR receiver
B1H19_RS06100	COG1017	nitric oxide dioxygenase activity
B1H19_RS06100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1H19_RS06130	COG0745	RESPONSE REGULATOR receiver
B1H19_RS06135	COG2205	protein histidine kinase activity
B1H19_RS06140	COG1136	(ABC) transporter
B1H19_RS06140	COG0577	efflux transmembrane transporter activity
B1H19_RS06145	COG0577	efflux transmembrane transporter activity
B1H19_RS06145	COG1136	(ABC) transporter
B1H19_RS06195	COG4221	oxidoreductase activity
B1H19_RS06225	COG0662	Cupin 2, conserved barrel domain protein
B1H19_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS06255	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS06260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1H19_RS06295	COG1129	ABC transporter
B1H19_RS06300	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1H19_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS06335	COG1802	Transcriptional regulator
B1H19_RS06365	COG0504	CTP synthase activity
B1H19_RS06440	COG2239	Acts as a magnesium transporter
B1H19_RS06445	COG0516	GMP reductase activity
B1H19_RS06445	COG0517	IMP dehydrogenase activity
B1H19_RS06455	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B1H19_RS06460	COG1316	TRANSCRIPTIONal
B1H19_RS06465	COG1215	transferase activity, transferring glycosyl groups
B1H19_RS06480	COG3469	chitinase activity
B1H19_RS06485	COG0747	negative chemotaxis
B1H19_RS06500	COG0668	transmembrane transport
B1H19_RS06510	COG2326	polyphosphate kinase activity
B1H19_RS06515	COG0516	GMP reductase activity
B1H19_RS06515	COG0517	IMP dehydrogenase activity
B1H19_RS06530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1H19_RS06535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1H19_RS06595	COG2814	Major facilitator Superfamily
B1H19_RS06605	COG1063	alcohol dehydrogenase
B1H19_RS06610	COG1070	Carbohydrate kinase
B1H19_RS06655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1H19_RS06665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1H19_RS06680	COG0009	L-threonylcarbamoyladenylate synthase
B1H19_RS06730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1H19_RS06740	COG2080	2 iron, 2 sulfur cluster binding
B1H19_RS06745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1H19_RS06750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS06760	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B1H19_RS06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS06870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1H19_RS06880	COG3290	protein histidine kinase activity
B1H19_RS06890	COG0443	Heat shock 70 kDa protein
B1H19_RS06895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1H19_RS06930	COG4213	ABC transporter substrate-binding protein
B1H19_RS06940	COG4214	carbohydrate transport
B1H19_RS06950	COG1302	Protein conserved in bacteria
B1H19_RS06955	COG0339	signal peptide processing
B1H19_RS06960	COG2329	Antibiotic biosynthesis monooxygenase
B1H19_RS06965	COG0583	DNA-binding transcription factor activity
B1H19_RS07000	COG1957	nucleoside hydrolase
B1H19_RS07005	COG0477	Major facilitator Superfamily
B1H19_RS07010	COG4638	Rieske (2fe-2S)
B1H19_RS07015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1H19_RS07025	COG1414	Transcriptional regulator
B1H19_RS07030	COG2186	Transcriptional regulator
B1H19_RS07100	COG1120	ATPase activity
B1H19_RS07105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1H19_RS07120	COG1132	(ABC) transporter
B1H19_RS07125	COG2274	protein secretion by the type I secretion system
B1H19_RS07140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1H19_RS07140	COG1796	DNA polymerase
B1H19_RS07160	COG0156	8-amino-7-oxononanoate synthase activity
B1H19_RS07165	COG1063	alcohol dehydrogenase
B1H19_RS07185	COG0181	hydroxymethylbilane synthase activity
B1H19_RS07205	COG2318	DinB family
B1H19_RS07225	COG0745	RESPONSE REGULATOR receiver
B1H19_RS07230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1H19_RS07230	COG1024	Enoyl-CoA hydratase
B1H19_RS07265	COG3585	molybdate ion transport
B1H19_RS07280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS07285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1H19_RS07290	COG3835	regulator
B1H19_RS07340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1H19_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS07375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1H19_RS07385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1H19_RS07385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1H19_RS07400	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS07450	COG0386	Belongs to the glutathione peroxidase family
B1H19_RS07465	COG1132	(ABC) transporter
B1H19_RS07475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B1H19_RS07490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1H19_RS07540	COG2226	methyltransferase
B1H19_RS07545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1H19_RS07570	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS07575	COG0825	malonyl-CoA metabolic process
B1H19_RS07575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1H19_RS07605	COG0697	spore germination
B1H19_RS07625	COG1695	Transcriptional regulator
B1H19_RS07655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1H19_RS07655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1H19_RS07665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1H19_RS07685	COG1716	ATPase activity
B1H19_RS07705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1H19_RS07735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1H19_RS07745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1H19_RS07755	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B1H19_RS07760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1H19_RS07785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1H19_RS07790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1H19_RS07805	COG0596	Alpha beta hydrolase
B1H19_RS07830	COG2146	nitrite reductase [NAD(P)H] activity
B1H19_RS07860	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B1H19_RS07880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1H19_RS07885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B1H19_RS07890	COG1984	allophanate hydrolase subunit 2
B1H19_RS07905	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS07910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1H19_RS07910	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS07960	COG0259	pyridoxamine-phosphate oxidase activity
B1H19_RS08020	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS08030	COG2070	2-Nitropropane dioxygenase
B1H19_RS08045	COG0515	serine threonine protein kinase
B1H19_RS08055	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS08075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1H19_RS08080	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1H19_RS08085	COG1120	ATPase activity
B1H19_RS08090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B1H19_RS08095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1H19_RS08105	COG2814	Major facilitator Superfamily
B1H19_RS08110	COG4264	IucA IucC family
B1H19_RS08115	COG0019	diaminopimelate decarboxylase activity
B1H19_RS08130	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B1H19_RS08145	COG2111	Na H antiporter
B1H19_RS08145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1H19_RS08155	COG1006	Multisubunit Na H antiporter MnhC subunit
B1H19_RS08160	COG1007	ATP synthesis coupled electron transport
B1H19_RS08170	COG3285	dna ligase
B1H19_RS08170	COG1793	dna ligase
B1H19_RS08175	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B1H19_RS08230	COG2376	Dihydroxyacetone kinase
B1H19_RS08235	COG1461	Dihydroxyacetone kinase
B1H19_RS08290	COG0395	ABC-type sugar transport system, permease component
B1H19_RS08310	COG1793	dna ligase
B1H19_RS08330	COG1011	Hydrolase
B1H19_RS08345	COG2124	cytochrome p450
B1H19_RS08350	COG1309	transcriptional regulator
B1H19_RS08360	COG1968	undecaprenyl-diphosphatase activity
B1H19_RS08380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1H19_RS08405	COG2264	protein methyltransferase activity
B1H19_RS08415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS08445	COG2814	Major facilitator Superfamily
B1H19_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS08460	COG0519	Catalyzes the synthesis of GMP from XMP
B1H19_RS08475	COG2816	NAD+ diphosphatase activity
B1H19_RS08485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1H19_RS08490	COG0463	Glycosyl transferase, family 2
B1H19_RS08505	COG3217	Mosc domain protein beta barrel domain protein
B1H19_RS08505	COG0633	Ferredoxin
B1H19_RS08525	COG0464	growth
B1H19_RS08535	COG1349	DNA-binding transcription factor activity
B1H19_RS08590	COG1940	carbohydrate kinase activity
B1H19_RS08595	COG2223	nitrite transmembrane transporter activity
B1H19_RS08610	COG2197	response regulator
B1H19_RS08615	COG4585	Histidine kinase
B1H19_RS08645	COG3345	alpha-galactosidase
B1H19_RS08670	COG2318	DinB family
B1H19_RS08675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1H19_RS08705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1H19_RS08740	COG0584	glycerophosphoryl diester phosphodiesterase
B1H19_RS08750	COG0765	amino acid transport
B1H19_RS08785	COG0671	phosphoesterase, PA-phosphatase related
B1H19_RS08830	COG0475	glutathione-regulated potassium exporter activity
B1H19_RS08845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1H19_RS08860	COG3629	intracellular signal transduction
B1H19_RS08860	COG3903	Transcriptional regulator
B1H19_RS08875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1H19_RS08880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1H19_RS08885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1H19_RS08895	COG0154	amidase activity
B1H19_RS08900	COG1136	(ABC) transporter
B1H19_RS08900	COG0577	efflux transmembrane transporter activity
B1H19_RS08905	COG2177	Part of the ABC transporter FtsEX involved in
B1H19_RS08925	COG4585	Histidine kinase
B1H19_RS08930	COG2197	response regulator
B1H19_RS08955	COG3903	Transcriptional regulator
B1H19_RS08955	COG3629	intracellular signal transduction
B1H19_RS08960	COG2175	clavaminate synthase activity
B1H19_RS08965	COG3251	PFAM MbtH domain protein
B1H19_RS08970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1H19_RS08990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1H19_RS09000	COG0512	Glutamine amidotransferase of anthranilate synthase
B1H19_RS09010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1H19_RS09015	COG0134	indole-3-glycerol-phosphate synthase activity
B1H19_RS09045	COG0583	DNA-binding transcription factor activity
B1H19_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS09075	COG4106	trans-aconitate 2-methyltransferase activity
B1H19_RS09085	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS09100	COG0697	spore germination
B1H19_RS09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1H19_RS09120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1H19_RS09125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1H19_RS09135	COG2175	clavaminate synthase activity
B1H19_RS09160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1H19_RS09210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1H19_RS09215	COG0140	phosphoribosyl-ATP diphosphatase activity
B1H19_RS09220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1H19_RS09225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1H19_RS09225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1H19_RS09230	COG3201	nicotinamide mononucleotide transporter
B1H19_RS09245	COG1090	epimerase
B1H19_RS09260	COG2233	PERMEase
B1H19_RS09280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1H19_RS09305	COG0531	amino acid
B1H19_RS09325	COG2390	Transcriptional regulator
B1H19_RS09330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1H19_RS09345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1H19_RS09360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1H19_RS09385	COG0284	orotidine-5'-phosphate decarboxylase activity
B1H19_RS09390	COG0167	dihydroorotate dehydrogenase activity
B1H19_RS09395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1H19_RS09400	COG0505	Belongs to the CarA family
B1H19_RS09410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1H19_RS09415	COG0540	Belongs to the ATCase OTCase family
B1H19_RS09420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1H19_RS09430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1H19_RS09435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1H19_RS09440	COG0006	proline dipeptidase activity
B1H19_RS09450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1H19_RS09455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1H19_RS09460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1H19_RS09465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1H19_RS09470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1H19_RS09480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1H19_RS09485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1H19_RS09500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1H19_RS09520	COG0124	histidyl-tRNA synthetase
B1H19_RS09535	COG1196	nuclear chromosome segregation
B1H19_RS09540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1H19_RS09545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1H19_RS09550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1H19_RS09555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1H19_RS09565	COG2255	four-way junction helicase activity
B1H19_RS09570	COG0632	four-way junction helicase activity
B1H19_RS09575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1H19_RS09580	COG0217	transcriptional regulatory protein
B1H19_RS09585	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1H19_RS09590	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B1H19_RS09600	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS09605	COG1560	Kdo2-lipid A biosynthetic process
B1H19_RS09610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1H19_RS09645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1H19_RS09660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1H19_RS09705	COG0454	-acetyltransferase
B1H19_RS09705	COG0456	acetyltransferase
B1H19_RS09715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1H19_RS09760	COG1648	precorrin-2 dehydrogenase activity
B1H19_RS09760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1H19_RS09765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1H19_RS09780	COG1464	Belongs to the NlpA lipoprotein family
B1H19_RS09785	COG2011	ABC-type metal ion transport system permease component
B1H19_RS09790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1H19_RS09825	COG0477	Major facilitator Superfamily
B1H19_RS09835	COG0165	Argininosuccinate lyase
B1H19_RS09840	COG0137	argininosuccinate synthase activity
B1H19_RS09860	COG1438	arginine binding
B1H19_RS09865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1H19_RS09870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1H19_RS09875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1H19_RS09880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1H19_RS09890	COG2197	response regulator
B1H19_RS09910	COG0697	spore germination
B1H19_RS09920	COG1649	PFAM Uncharacterised BCR, COG1649
B1H19_RS09930	COG0201	protein transport
B1H19_RS09950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1H19_RS09950	COG0072	phenylalanine-tRNA ligase activity
B1H19_RS09955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1H19_RS09960	COG5002	protein histidine kinase activity
B1H19_RS09965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1H19_RS09970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1H19_RS09975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1H19_RS09980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1H19_RS09990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1H19_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS10035	COG2186	Transcriptional regulator
B1H19_RS10040	COG0531	amino acid
B1H19_RS10045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B1H19_RS10065	COG2233	PERMEase
B1H19_RS10090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1H19_RS10100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS10110	COG0805	protein transport
B1H19_RS10115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1H19_RS10135	COG2378	regulation of single-species biofilm formation
B1H19_RS10150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B1H19_RS10160	COG1609	Transcriptional regulator
B1H19_RS10165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B1H19_RS10170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B1H19_RS10185	COG4122	O-methyltransferase activity
B1H19_RS10190	COG1222	aaa ATPase
B1H19_RS10215	COG1994	Peptidase M50
B1H19_RS10215	COG0517	IMP dehydrogenase activity
B1H19_RS10225	COG2197	response regulator
B1H19_RS10235	COG0747	negative chemotaxis
B1H19_RS10240	COG0546	phosphoglycolate phosphatase activity
B1H19_RS10245	COG0646	methionine synthase
B1H19_RS10245	COG1410	methionine synthase
B1H19_RS10250	COG1414	Transcriptional regulator
B1H19_RS10255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1H19_RS10260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1H19_RS10265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B1H19_RS10270	COG2186	Transcriptional regulator
B1H19_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS10290	COG0215	cysteine-tRNA ligase activity
B1H19_RS10310	COG0598	Magnesium transport protein CorA
B1H19_RS10320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS10325	COG0667	Aldo Keto reductase
B1H19_RS10355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1H19_RS10365	COG0564	pseudouridine synthase activity
B1H19_RS10375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1H19_RS10380	COG0488	(ABC) transporter
B1H19_RS10395	COG0745	RESPONSE REGULATOR receiver
B1H19_RS10400	COG2205	protein histidine kinase activity
B1H19_RS10405	COG2249	NAD(P)H dehydrogenase (quinone) activity
B1H19_RS10410	COG0640	Transcriptional regulator
B1H19_RS10450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B1H19_RS10455	COG2149	membrane
B1H19_RS10480	COG1309	transcriptional regulator
B1H19_RS10485	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS10495	COG3876	Protein conserved in bacteria
B1H19_RS10500	COG0596	Alpha beta hydrolase
B1H19_RS10545	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS10590	COG1309	transcriptional regulator
B1H19_RS10605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B1H19_RS10610	COG2188	Transcriptional regulator
B1H19_RS10615	COG2814	Major facilitator Superfamily
B1H19_RS10615	COG0477	Major facilitator Superfamily
B1H19_RS10650	COG1834	amidinotransferase
B1H19_RS10655	COG1725	Transcriptional regulator
B1H19_RS10660	COG0367	asparagine synthase
B1H19_RS10665	COG0456	acetyltransferase
B1H19_RS10670	COG2226	methyltransferase
B1H19_RS10685	COG0531	amino acid
B1H19_RS10705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1H19_RS10710	COG0587	DNA-directed DNA polymerase activity
B1H19_RS10735	COG0330	HflC and HflK could
B1H19_RS10755	COG0765	amino acid transport
B1H19_RS10765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1H19_RS10770	COG1799	cell septum assembly
B1H19_RS10775	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS10780	COG0477	Major facilitator Superfamily
B1H19_RS10790	COG0671	phosphoesterase, PA-phosphatase related
B1H19_RS10805	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS10810	COG1652	LysM domain
B1H19_RS10825	COG1160	GTP binding
B1H19_RS10835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1H19_RS10860	COG1187	pseudouridine synthase activity
B1H19_RS10865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1H19_RS10870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1H19_RS10885	COG0686	Belongs to the AlaDH PNT family
B1H19_RS10895	COG0494	nUDIX hydrolase
B1H19_RS10900	COG0504	CTP synthase activity
B1H19_RS10905	COG3387	PFAM Glycoside hydrolase 15-related
B1H19_RS10950	COG0497	DNA recombination
B1H19_RS10955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1H19_RS10975	COG1120	ATPase activity
B1H19_RS10980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1H19_RS10990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1H19_RS11005	COG0647	UMP catabolic process
B1H19_RS11020	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1H19_RS11060	COG2094	Belongs to the DNA glycosylase MPG family
B1H19_RS11070	COG1881	PFAM PEBP family protein
B1H19_RS11095	COG1119	ATPase activity
B1H19_RS11115	COG2197	response regulator
B1H19_RS11120	COG4585	Histidine kinase
B1H19_RS11125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1H19_RS11140	COG0842	Transport permease protein
B1H19_RS11140	COG1131	(ABC) transporter
B1H19_RS11140	COG1716	ATPase activity
B1H19_RS11145	COG0560	Phosphoserine phosphatase
B1H19_RS11145	COG3830	Belongs to the UPF0237 family
B1H19_RS11160	COG2807	transmembrane transport
B1H19_RS11165	COG2186	Transcriptional regulator
B1H19_RS11170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B1H19_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS11190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1H19_RS11210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1H19_RS11215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1H19_RS11230	COG1404	Belongs to the peptidase S8 family
B1H19_RS11255	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS11260	COG4689	acetoacetate decarboxylase
B1H19_RS11270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1H19_RS11285	COG3387	PFAM Glycoside hydrolase 15-related
B1H19_RS11325	COG1024	Enoyl-CoA hydratase
B1H19_RS11335	COG0488	(ABC) transporter
B1H19_RS11350	COG0235	Class ii aldolase
B1H19_RS11365	COG1653	transport
B1H19_RS11380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B1H19_RS11385	COG1492	cobalamin metabolic process
B1H19_RS11395	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B1H19_RS11400	COG1797	cobyrinic acid a,c-diamide synthase activity
B1H19_RS11410	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B1H19_RS11435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1H19_RS11440	COG1917	Cupin 2, conserved barrel domain protein
B1H19_RS11450	COG1902	pentaerythritol trinitrate reductase activity
B1H19_RS11465	COG2226	methyltransferase
B1H19_RS11480	COG1414	Transcriptional regulator
B1H19_RS11490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1H19_RS11495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1H19_RS11500	COG2261	transglycosylase associated protein
B1H19_RS11540	COG2171	N-acyltransferase activity
B1H19_RS11545	COG3226	Transcriptional regulator
B1H19_RS11560	COG0822	iron-sulfur transferase activity
B1H19_RS11565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1H19_RS11570	COG0396	ATPase activity
B1H19_RS11580	COG0719	Fe-S assembly protein
B1H19_RS11620	COG0109	protoheme IX farnesyltransferase activity
B1H19_RS11630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1H19_RS11645	COG0363	glucosamine-6-phosphate deaminase activity
B1H19_RS11650	COG0166	Belongs to the GPI family
B1H19_RS11660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1H19_RS11665	COG0149	triose-phosphate isomerase activity
B1H19_RS11670	COG0126	phosphoglycerate kinase activity
B1H19_RS11675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1H19_RS11680	COG1481	regulation of sporulation
B1H19_RS11685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B1H19_RS11690	COG1660	Displays ATPase and GTPase activities
B1H19_RS11695	COG0322	excinuclease ABC activity
B1H19_RS11720	COG1609	Transcriptional regulator
B1H19_RS11730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1H19_RS11750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1H19_RS11770	COG0556	nucleotide-excision repair
B1H19_RS11775	COG0584	glycerophosphoryl diester phosphodiesterase
B1H19_RS11840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1H19_RS11865	COG0237	dephospho-CoA kinase activity
B1H19_RS11875	COG0539	negative regulation of cytoplasmic translation
B1H19_RS11880	COG2226	methyltransferase
B1H19_RS11885	COG1643	Atp-dependent helicase
B1H19_RS11915	COG2050	protein possibly involved in aromatic compounds catabolism
B1H19_RS11935	COG0411	ABC transporter
B1H19_RS11990	COG1470	cell adhesion involved in biofilm formation
B1H19_RS11990	COG0366	Alpha amylase catalytic
B1H19_RS12005	COG2267	carboxylic ester hydrolase activity
B1H19_RS12015	COG0640	Transcriptional regulator
B1H19_RS12030	COG0067	glutamate synthase
B1H19_RS12030	COG0069	glutamate synthase activity
B1H19_RS12030	COG0070	glutamate synthase
B1H19_RS12075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1H19_RS12085	COG0159	tryptophan synthase activity
B1H19_RS12090	COG0133	tryptophan synthase activity
B1H19_RS12100	COG0134	indole-3-glycerol-phosphate synthase activity
B1H19_RS12120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1H19_RS12125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1H19_RS12135	COG0583	DNA-binding transcription factor activity
B1H19_RS12145	COG1053	succinate dehydrogenase
B1H19_RS12150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1H19_RS12170	COG0107	imidazoleglycerol-phosphate synthase activity
B1H19_RS12175	COG0251	oxidation-reduction process
B1H19_RS12180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1H19_RS12185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1H19_RS12190	COG0131	Imidazoleglycerol-phosphate dehydratase
B1H19_RS12195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1H19_RS12200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1H19_RS12215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1H19_RS12235	COG1432	Conserved Protein
B1H19_RS12240	COG0587	DNA-directed DNA polymerase activity
B1H19_RS12290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1H19_RS12305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1H19_RS12310	COG3599	regulation of cell shape
B1H19_RS12320	COG1799	cell septum assembly
B1H19_RS12345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B1H19_RS12350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1H19_RS12360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1H19_RS12365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1H19_RS12375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1H19_RS12390	COG0275	rRNA processing
B1H19_RS12400	COG0714	Associated with various cellular activities
B1H19_RS12420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1H19_RS12430	COG1132	(ABC) transporter
B1H19_RS12440	COG1309	transcriptional regulator
B1H19_RS12465	COG0352	thiamine-phosphate diphosphorylase activity
B1H19_RS12480	COG2022	thiamine diphosphate biosynthetic process
B1H19_RS12480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1H19_RS12490	COG2022	thiamine diphosphate biosynthetic process
B1H19_RS12495	COG2815	serine threonine protein kinase
B1H19_RS12495	COG0515	serine threonine protein kinase
B1H19_RS12500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1H19_RS12505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1H19_RS12510	COG2193	ferroxidase activity
B1H19_RS12520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1H19_RS12530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1H19_RS12535	COG0205	6-phosphofructokinase activity
B1H19_RS12540	COG2197	response regulator
B1H19_RS12570	COG1940	carbohydrate kinase activity
B1H19_RS12580	COG0003	Pfam Anion-transporting ATPase
B1H19_RS12600	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS12640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1H19_RS12645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1H19_RS12650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1H19_RS12655	COG0723	plastoquinol--plastocyanin reductase activity
B1H19_RS12660	COG2010	Cytochrome c
B1H19_RS12665	COG1845	cytochrome c oxidase, subunit III
B1H19_RS12675	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS12685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1H19_RS12690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1H19_RS12700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1H19_RS12720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1H19_RS12750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1H19_RS12755	COG2197	response regulator
B1H19_RS12760	COG4585	Histidine kinase
B1H19_RS12795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1H19_RS12810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B1H19_RS12815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1H19_RS12820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1H19_RS12825	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1H19_RS12835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1H19_RS12845	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS12875	COG0321	lipoyl(octanoyl) transferase activity
B1H19_RS12880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1H19_RS12920	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1H19_RS12920	COG1902	pentaerythritol trinitrate reductase activity
B1H19_RS12935	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS12965	COG0745	RESPONSE REGULATOR receiver
B1H19_RS13055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1H19_RS13055	COG0515	serine threonine protein kinase
B1H19_RS13065	COG0366	Alpha amylase catalytic
B1H19_RS13075	COG0395	ABC-type sugar transport system, permease component
B1H19_RS13080	COG1175	transmembrane transport
B1H19_RS13085	COG2182	Extracellular solute-binding protein
B1H19_RS13090	COG0366	Alpha amylase catalytic
B1H19_RS13095	COG1609	Transcriptional regulator
B1H19_RS13105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B1H19_RS13110	COG0174	glutamine synthetase
B1H19_RS13115	COG2267	carboxylic ester hydrolase activity
B1H19_RS13125	COG2132	Multicopper oxidase
B1H19_RS13130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1H19_RS13130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1H19_RS13135	COG2814	Major facilitator Superfamily
B1H19_RS13155	COG1309	transcriptional regulator
B1H19_RS13160	COG0477	Major facilitator Superfamily
B1H19_RS13165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1H19_RS13185	COG1994	Peptidase M50
B1H19_RS13200	COG0395	ABC-type sugar transport system, permease component
B1H19_RS13205	COG1175	transmembrane transport
B1H19_RS13220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1H19_RS13240	COG5398	heme oxygenase
B1H19_RS13255	COG2837	iron assimilation
B1H19_RS13260	COG0672	)-iron permease
B1H19_RS13275	COG1309	transcriptional regulator
B1H19_RS13290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1H19_RS13295	COG2814	Major facilitator Superfamily
B1H19_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS13335	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
B1H19_RS13340	COG3022	response to hydroperoxide
B1H19_RS13345	COG0800	Aldolase
B1H19_RS13360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1H19_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS13380	COG2030	dehydratase
B1H19_RS13385	COG1131	(ABC) transporter
B1H19_RS13395	COG4585	Histidine kinase
B1H19_RS13400	COG2197	response regulator
B1H19_RS13410	COG0183	Belongs to the thiolase family
B1H19_RS13415	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS13425	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1H19_RS13435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS13455	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS13460	COG1309	transcriptional regulator
B1H19_RS13495	COG3845	ABC transporter
B1H19_RS13505	COG0183	Belongs to the thiolase family
B1H19_RS13510	COG2124	cytochrome p450
B1H19_RS13520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1H19_RS13540	COG0477	Major facilitator Superfamily
B1H19_RS13865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B1H19_RS13875	COG0662	Cupin 2, conserved barrel domain protein
B1H19_RS13880	COG1072	(Pantothenic acid kinase))
B1H19_RS13890	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B1H19_RS13900	COG2259	Doxx family
B1H19_RS13965	COG0800	Aldolase
B1H19_RS13990	COG1358	cellular component organization or biogenesis
B1H19_RS14035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1H19_RS14045	COG0477	Major facilitator Superfamily
B1H19_RS14050	COG1309	transcriptional regulator
B1H19_RS14065	COG4585	Histidine kinase
B1H19_RS14070	COG2197	response regulator
B1H19_RS14085	COG0789	Transcriptional regulator
B1H19_RS14110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1H19_RS14115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1H19_RS14120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1H19_RS14125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1H19_RS14155	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B1H19_RS14160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1H19_RS14165	COG1609	Transcriptional regulator
B1H19_RS14170	COG1764	response to oxidative stress
B1H19_RS14175	COG2130	NADP-dependent
B1H19_RS14185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B1H19_RS14205	COG0500	methyltransferase
B1H19_RS14210	COG4981	capsule polysaccharide biosynthetic process
B1H19_RS14220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1H19_RS14230	COG2835	tetraacyldisaccharide 4'-kinase activity
B1H19_RS14245	COG1077	Cell shape determining protein MreB Mrl
B1H19_RS14250	COG0406	alpha-ribazole phosphatase activity
B1H19_RS14255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1H19_RS14285	COG1070	Carbohydrate kinase
B1H19_RS14290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1H19_RS14295	COG0358	DNA primase activity
B1H19_RS14310	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1H19_RS14320	COG0243	molybdopterin cofactor binding
B1H19_RS14330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1H19_RS14365	COG1017	nitric oxide dioxygenase activity
B1H19_RS14365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1H19_RS14385	COG1473	amidohydrolase
B1H19_RS14405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1H19_RS14410	COG2146	nitrite reductase [NAD(P)H] activity
B1H19_RS14410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1H19_RS14425	COG0640	Transcriptional regulator
B1H19_RS14440	COG0531	amino acid
B1H19_RS14465	COG1175	transmembrane transport
B1H19_RS14470	COG0395	ABC-type sugar transport system, permease component
B1H19_RS14475	COG0477	Major facilitator Superfamily
B1H19_RS14515	COG0574	Belongs to the PEP-utilizing enzyme family
B1H19_RS14515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1H19_RS14520	COG1846	Transcriptional regulator
B1H19_RS14540	COG0477	Major facilitator Superfamily
B1H19_RS14545	COG0667	Aldo Keto reductase
B1H19_RS14550	COG1309	transcriptional regulator
B1H19_RS14555	COG2197	response regulator
B1H19_RS14570	COG0423	glycine-tRNA ligase activity
B1H19_RS14580	COG1121	(ABC) transporter
B1H19_RS14585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1H19_RS14595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1H19_RS14600	COG1381	Involved in DNA repair and RecF pathway recombination
B1H19_RS14625	COG2124	cytochrome p450
B1H19_RS14640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1H19_RS14665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1H19_RS14690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1H19_RS14705	COG1486	melibiose metabolic process
B1H19_RS14720	COG4948	Mandelate Racemase Muconate Lactonizing
B1H19_RS14730	COG1234	tRNA 3'-trailer cleavage
B1H19_RS14735	COG0537	adenosine 5'-monophosphoramidase activity
B1H19_RS14770	COG0484	heat shock protein binding
B1H19_RS14775	COG1420	regulation of RNA biosynthetic process
B1H19_RS14810	COG0481	GTPase activity
B1H19_RS14815	COG0268	Binds directly to 16S ribosomal RNA
B1H19_RS14830	COG1234	tRNA 3'-trailer cleavage
B1H19_RS14835	COG1555	photosystem II stabilization
B1H19_RS14840	COG1307	EDD domain protein, DegV family
B1H19_RS14850	COG0495	leucyl-tRNA aminoacylation
B1H19_RS14890	COG0588	phosphoglycerate mutase activity
B1H19_RS14895	COG0799	negative regulation of ribosome biogenesis
B1H19_RS14905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1H19_RS14910	COG0501	Belongs to the peptidase M48B family
B1H19_RS14925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1H19_RS14935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1H19_RS14945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1H19_RS14950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1H19_RS14955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1H19_RS14960	COG1530	ribonuclease E activity
B1H19_RS14985	COG0772	Belongs to the SEDS family
B1H19_RS14990	COG0768	penicillin binding
B1H19_RS15005	COG1077	Cell shape determining protein MreB Mrl
B1H19_RS15010	COG0105	UTP biosynthetic process
B1H19_RS15020	COG0285	dihydrofolate synthase activity
B1H19_RS15025	COG0768	penicillin binding
B1H19_RS15035	COG0525	valine-tRNA ligase activity
B1H19_RS15045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1H19_RS15050	COG0740	serine-type endopeptidase activity
B1H19_RS15055	COG0740	serine-type endopeptidase activity
B1H19_RS15060	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1H19_RS15085	COG3594	Acyltransferase
B1H19_RS15110	COG0698	ribose 5-phosphate isomerase
B1H19_RS15115	COG1113	amino acid transport
B1H19_RS15125	COG1113	amino acid transport
B1H19_RS15130	COG1113	amino acid transport
B1H19_RS15135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1H19_RS15140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B1H19_RS15195	COG4266	Belongs to the allantoicase family
B1H19_RS15200	COG0583	DNA-binding transcription factor activity
B1H19_RS15240	COG0668	transmembrane transport
B1H19_RS15250	COG1940	carbohydrate kinase activity
B1H19_RS15250	COG1846	Transcriptional regulator
B1H19_RS15260	COG1175	transmembrane transport
B1H19_RS15265	COG0395	ABC-type sugar transport system, permease component
B1H19_RS15270	COG1486	melibiose metabolic process
B1H19_RS15285	COG2186	Transcriptional regulator
B1H19_RS15295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1H19_RS15345	COG0629	single-stranded DNA binding
B1H19_RS15350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1H19_RS15445	COG1077	Cell shape determining protein MreB Mrl
B1H19_RS15450	COG1289	transmembrane transporter activity
B1H19_RS15455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B1H19_RS15470	COG3962	Belongs to the TPP enzyme family
B1H19_RS15475	COG3718	enzyme involved in inositol metabolism
B1H19_RS15485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1H19_RS15495	COG0673	inositol 2-dehydrogenase activity
B1H19_RS15500	COG2814	Major facilitator Superfamily
B1H19_RS15510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1H19_RS15520	COG0673	inositol 2-dehydrogenase activity
B1H19_RS15530	COG0586	Pfam SNARE associated Golgi protein
B1H19_RS15550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1H19_RS15565	COG0673	inositol 2-dehydrogenase activity
B1H19_RS15575	COG1472	Belongs to the glycosyl hydrolase 3 family
B1H19_RS15590	COG1554	hydrolase, family 65, central catalytic
B1H19_RS15595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1H19_RS15620	COG0667	Aldo Keto reductase
B1H19_RS15625	COG0789	Transcriptional regulator
B1H19_RS15630	COG1946	Acyl-CoA thioesterase
B1H19_RS15640	COG1309	transcriptional regulator
B1H19_RS15645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1H19_RS15660	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS15675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1H19_RS15690	COG4977	sequence-specific DNA binding
B1H19_RS15695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B1H19_RS15715	COG3979	chitinase
B1H19_RS15725	COG0745	RESPONSE REGULATOR receiver
B1H19_RS15745	COG0297	glycogen (starch) synthase activity
B1H19_RS15765	COG0667	Aldo Keto reductase
B1H19_RS15820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS15825	COG3473	Maleate cis-trans isomerase
B1H19_RS15840	COG0154	amidase activity
B1H19_RS15850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B1H19_RS15855	COG0765	amino acid transport
B1H19_RS15860	COG0765	amino acid transport
B1H19_RS15865	COG1126	abc transporter atp-binding protein
B1H19_RS15880	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS15885	COG3397	chitin binding
B1H19_RS15935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1H19_RS15945	COG2188	Transcriptional regulator
B1H19_RS15955	COG0673	inositol 2-dehydrogenase activity
B1H19_RS15960	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1H19_RS15965	COG0706	membrane insertase activity
B1H19_RS15980	COG1022	Amp-dependent synthetase and ligase
B1H19_RS15995	COG0539	negative regulation of cytoplasmic translation
B1H19_RS16020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1H19_RS16030	COG2733	membrane
B1H19_RS16065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1H19_RS16080	COG2205	protein histidine kinase activity
B1H19_RS16110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1H19_RS16120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1H19_RS16125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1H19_RS16130	COG1263	PTS System
B1H19_RS16135	COG1263	PTS System
B1H19_RS16140	COG1234	tRNA 3'-trailer cleavage
B1H19_RS16165	COG1113	amino acid transport
B1H19_RS16175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1H19_RS16185	COG1335	isochorismatase
B1H19_RS16220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1H19_RS16225	COG0222	ribosome binding
B1H19_RS16230	COG0277	FAD linked oxidase domain protein
B1H19_RS16235	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B1H19_RS16245	COG1174	glycine betaine transport
B1H19_RS16255	COG1174	glycine betaine transport
B1H19_RS16285	COG0477	Major facilitator Superfamily
B1H19_RS16300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS16315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B1H19_RS16325	COG2814	Major facilitator Superfamily
B1H19_RS16330	COG0583	DNA-binding transcription factor activity
B1H19_RS16340	COG1678	Uncharacterized ACR, COG1678
B1H19_RS16345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1H19_RS16350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1H19_RS16355	COG0776	regulation of translation
B1H19_RS16365	COG3973	AAA domain
B1H19_RS16390	COG2223	nitrite transmembrane transporter activity
B1H19_RS16400	COG0583	DNA-binding transcription factor activity
B1H19_RS16415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1H19_RS16420	COG0793	Belongs to the peptidase S41A family
B1H19_RS16425	COG2177	Part of the ABC transporter FtsEX involved in
B1H19_RS16430	COG2884	Cell division ATP-binding protein ftsE
B1H19_RS16445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1H19_RS16450	COG0515	serine threonine protein kinase
B1H19_RS16455	COG0515	serine threonine protein kinase
B1H19_RS16465	COG1653	transport
B1H19_RS16470	COG1175	transmembrane transport
B1H19_RS16475	COG0395	ABC-type sugar transport system, permease component
B1H19_RS16490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1H19_RS16490	COG0463	Glycosyl transferase, family 2
B1H19_RS16515	COG0463	Glycosyl transferase, family 2
B1H19_RS16530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1H19_RS16530	COG0463	Glycosyl transferase, family 2
B1H19_RS16535	COG1309	transcriptional regulator
B1H19_RS16545	COG1134	teichoic acid transport
B1H19_RS16570	COG0653	protein targeting
B1H19_RS16580	COG3214	Protein conserved in bacteria
B1H19_RS16585	COG2197	response regulator
B1H19_RS16590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B1H19_RS16605	COG0823	Involved in the tonB-independent uptake of proteins
B1H19_RS16610	COG5000	phosphorelay sensor kinase activity
B1H19_RS16610	COG5002	protein histidine kinase activity
B1H19_RS16615	COG0745	RESPONSE REGULATOR receiver
B1H19_RS16620	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1H19_RS16640	COG0714	Associated with various cellular activities
B1H19_RS16685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1H19_RS16690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1H19_RS16690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1H19_RS16690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1H19_RS16700	COG1482	cell wall glycoprotein biosynthetic process
B1H19_RS16710	COG2835	tetraacyldisaccharide 4'-kinase activity
B1H19_RS16755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B1H19_RS16760	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B1H19_RS16760	COG0778	Nitroreductase
B1H19_RS16795	COG1316	TRANSCRIPTIONal
B1H19_RS16810	COG1316	TRANSCRIPTIONal
B1H19_RS16840	COG1316	TRANSCRIPTIONal
B1H19_RS16900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1H19_RS16940	COG2205	protein histidine kinase activity
B1H19_RS16945	COG0745	RESPONSE REGULATOR receiver
B1H19_RS16950	COG3104	oligopeptide transport
B1H19_RS16980	COG1366	Belongs to the anti-sigma-factor antagonist family
B1H19_RS16985	COG1191	sigma factor activity
B1H19_RS16990	COG1228	amidohydrolase
B1H19_RS17000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1H19_RS17005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B1H19_RS17020	COG1131	(ABC) transporter
B1H19_RS17030	COG0019	diaminopimelate decarboxylase activity
B1H19_RS17040	COG2986	histidine ammonia-lyase
B1H19_RS17050	COG2755	lipolytic protein G-D-S-L family
B1H19_RS17055	COG0183	Belongs to the thiolase family
B1H19_RS17080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1H19_RS17080	COG0463	Glycosyl transferase, family 2
B1H19_RS17085	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS17095	COG0577	efflux transmembrane transporter activity
B1H19_RS17095	COG1136	(ABC) transporter
B1H19_RS17100	COG0577	efflux transmembrane transporter activity
B1H19_RS17105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1H19_RS17130	COG0148	phosphopyruvate hydratase activity
B1H19_RS17140	COG1652	LysM domain
B1H19_RS17145	COG2124	cytochrome p450
B1H19_RS17155	COG2814	Major facilitator Superfamily
B1H19_RS17175	COG2815	serine threonine protein kinase
B1H19_RS17175	COG0515	serine threonine protein kinase
B1H19_RS17200	COG2814	Major facilitator Superfamily
B1H19_RS17210	COG1316	TRANSCRIPTIONal
B1H19_RS17245	COG4585	Histidine kinase
B1H19_RS17255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1H19_RS17260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1H19_RS17265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1H19_RS17270	COG0193	aminoacyl-tRNA hydrolase activity
B1H19_RS17280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1H19_RS17290	COG1309	transcriptional regulator
B1H19_RS17295	COG4106	trans-aconitate 2-methyltransferase activity
B1H19_RS17315	COG2197	response regulator
B1H19_RS17320	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B1H19_RS17345	COG0515	serine threonine protein kinase
B1H19_RS17345	COG2815	serine threonine protein kinase
B1H19_RS17365	COG2318	DinB family
B1H19_RS17375	COG0488	(ABC) transporter
B1H19_RS17380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1H19_RS17385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1H19_RS17395	COG0084	hydrolase, TatD family'
B1H19_RS17415	COG0768	penicillin binding
B1H19_RS17440	COG1309	transcriptional regulator
B1H19_RS17445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1H19_RS17450	COG1122	ATPase activity
B1H19_RS17460	COG0310	cobalt ion transport
B1H19_RS17470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1H19_RS17505	COG4946	Tricorn protease homolog
B1H19_RS17505	COG0793	Belongs to the peptidase S41A family
B1H19_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS17520	COG2267	carboxylic ester hydrolase activity
B1H19_RS17525	COG2072	flavoprotein involved in K transport
B1H19_RS17540	COG0708	Exodeoxyribonuclease III
B1H19_RS17550	COG0789	Transcriptional regulator
B1H19_RS17560	COG2814	Major facilitator Superfamily
B1H19_RS17570	COG0546	phosphoglycolate phosphatase activity
B1H19_RS17585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1H19_RS17590	COG0315	cyclic pyranopterin monophosphate synthase activity
B1H19_RS17590	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1H19_RS17595	COG0315	cyclic pyranopterin monophosphate synthase activity
B1H19_RS17605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1H19_RS17610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1H19_RS17620	COG3263	regulation of cellular component size
B1H19_RS17635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B1H19_RS17655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1H19_RS17660	COG0477	Major facilitator Superfamily
B1H19_RS17665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1H19_RS17670	COG2188	Transcriptional regulator
B1H19_RS17720	COG3191	aminopeptidase activity
B1H19_RS17740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1H19_RS17745	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS17775	COG1247	-acetyltransferase
B1H19_RS17800	COG1846	Transcriptional regulator
B1H19_RS17815	COG1309	transcriptional regulator
B1H19_RS17830	COG0640	Transcriptional regulator
B1H19_RS17835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1H19_RS17855	COG0514	ATP-dependent DNA helicase (RecQ)
B1H19_RS17860	COG2205	protein histidine kinase activity
B1H19_RS17880	COG0640	Transcriptional regulator
B1H19_RS17890	COG1686	Belongs to the peptidase S11 family
B1H19_RS17915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1H19_RS17925	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS17935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1H19_RS17950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1H19_RS17975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B1H19_RS18005	COG0789	Transcriptional regulator
B1H19_RS18075	COG1024	Enoyl-CoA hydratase
B1H19_RS18090	COG0515	serine threonine protein kinase
B1H19_RS18090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1H19_RS18100	COG1309	transcriptional regulator
B1H19_RS18110	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS18120	COG0259	pyridoxamine-phosphate oxidase activity
B1H19_RS18135	COG1024	Enoyl-CoA hydratase
B1H19_RS18150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1H19_RS18160	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS18165	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS18185	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS18190	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS18235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B1H19_RS18245	COG0516	GMP reductase activity
B1H19_RS18255	COG1595	DNA-templated transcription, initiation
B1H19_RS18270	COG0583	DNA-binding transcription factor activity
B1H19_RS18280	COG4221	oxidoreductase activity
B1H19_RS18315	COG0726	polysaccharide deacetylase
B1H19_RS18325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1H19_RS18350	COG0802	atpase or kinase
B1H19_RS18355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1H19_RS18360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1H19_RS18375	COG0736	holo-[acyl-carrier-protein] synthase activity
B1H19_RS18380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1H19_RS18390	COG1072	(Pantothenic acid kinase))
B1H19_RS18395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1H19_RS18400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1H19_RS18405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1H19_RS18410	COG0488	(ABC) transporter
B1H19_RS18425	COG0101	tRNA pseudouridine synthase activity
B1H19_RS18430	COG0203	ribosomal protein L17
B1H19_RS18435	COG0202	RNA polymerase activity
B1H19_RS18440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1H19_RS18445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1H19_RS18450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1H19_RS18455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1H19_RS18460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1H19_RS18470	COG0563	adenylate kinase activity
B1H19_RS18480	COG0200	Binds to the 23S rRNA
B1H19_RS18485	COG1841	ribosomal large subunit assembly
B1H19_RS18490	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1H19_RS18495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1H19_RS18500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1H19_RS18505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1H19_RS18515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1H19_RS18520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1H19_RS18525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1H19_RS18530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1H19_RS18535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1H19_RS18540	COG0255	Belongs to the universal ribosomal protein uL29 family
B1H19_RS18545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1H19_RS18550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1H19_RS18555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1H19_RS18560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1H19_RS18565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1H19_RS18570	COG0089	rRNA binding
B1H19_RS18575	COG0088	Forms part of the polypeptide exit tunnel
B1H19_RS18580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1H19_RS18585	COG0051	transcription antitermination factor activity, RNA binding
B1H19_RS18590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1H19_RS18595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1H19_RS18600	COG0049	tRNA binding
B1H19_RS18605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1H19_RS18615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1H19_RS18620	COG0085	RNA polymerase activity
B1H19_RS18630	COG0222	ribosome binding
B1H19_RS18635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1H19_RS18650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1H19_RS18655	COG0250	Participates in transcription elongation, termination and antitermination
B1H19_RS18670	COG0436	Aminotransferase
B1H19_RS18675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1H19_RS18680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1H19_RS18690	COG2030	dehydratase
B1H19_RS18695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1H19_RS18710	COG0402	S-adenosylhomocysteine deaminase activity
B1H19_RS18715	COG0702	epimerase
B1H19_RS18725	COG1666	GTP binding
B1H19_RS18735	COG3304	Inner membrane component domain
B1H19_RS18740	COG1819	glycosyl
B1H19_RS18750	COG1007	ATP synthesis coupled electron transport
B1H19_RS18760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1H19_RS18765	COG0713	ATP synthesis coupled electron transport
B1H19_RS18770	COG0839	Belongs to the complex I subunit 6 family
B1H19_RS18775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS18780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1H19_RS18785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS18790	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS18795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS18805	COG1674	ftsk spoiiie
B1H19_RS18870	COG4585	Histidine kinase
B1H19_RS18875	COG4585	Histidine kinase
B1H19_RS18885	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1H19_RS18885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1H19_RS18890	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1H19_RS18925	COG5377	YqaJ viral recombinase family
B1H19_RS18930	COG3723	Recombinational DNA repair protein, rece pathway
B1H19_RS18955	COG0629	single-stranded DNA binding
B1H19_RS19110	COG0535	radical SAM domain protein
B1H19_RS19115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1H19_RS19150	COG0142	geranyltranstransferase activity
B1H19_RS19180	COG1007	ATP synthesis coupled electron transport
B1H19_RS19190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1H19_RS19195	COG0713	ATP synthesis coupled electron transport
B1H19_RS19200	COG0839	Belongs to the complex I subunit 6 family
B1H19_RS19205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS19210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1H19_RS19215	COG1034	ATP synthesis coupled electron transport
B1H19_RS19220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B1H19_RS19230	COG0649	NAD binding
B1H19_RS19235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS19240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1H19_RS19265	COG2226	methyltransferase
B1H19_RS19275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1H19_RS19290	COG1309	transcriptional regulator
B1H19_RS19295	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B1H19_RS19300	COG1278	Cold shock
B1H19_RS19305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS19340	COG1309	transcriptional regulator
B1H19_RS19440	COG1301	dicarboxylic acid transport
B1H19_RS19450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1H19_RS19460	COG0163	prenyltransferase activity
B1H19_RS19475	COG0109	protoheme IX farnesyltransferase activity
B1H19_RS19480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1H19_RS19490	COG2815	serine threonine protein kinase
B1H19_RS19490	COG0515	serine threonine protein kinase
B1H19_RS19505	COG2391	methyltransferase activity
B1H19_RS19525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1H19_RS19530	COG1333	cytochrome c biogenesis protein
B1H19_RS19535	COG0785	Cytochrome C biogenesis protein
B1H19_RS19550	COG0406	alpha-ribazole phosphatase activity
B1H19_RS19555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1H19_RS19565	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS19585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS19590	COG1742	UPF0060 membrane protein
B1H19_RS19600	COG1690	Belongs to the RtcB family
B1H19_RS19640	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B1H19_RS19645	COG0018	arginyl-trna synthetase
B1H19_RS19655	COG1404	Belongs to the peptidase S8 family
B1H19_RS19670	COG0113	porphobilinogen synthase activity
B1H19_RS19685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1H19_RS19685	COG1648	precorrin-2 dehydrogenase activity
B1H19_RS19690	COG0181	hydroxymethylbilane synthase activity
B1H19_RS19695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1H19_RS19700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B1H19_RS19750	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1H19_RS19760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1H19_RS19825	COG0579	oxidoreductase
B1H19_RS19830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1H19_RS19880	COG2423	ornithine cyclodeaminase activity
B1H19_RS19895	COG3135	benzoate transporter
B1H19_RS19900	COG1846	Transcriptional regulator
B1H19_RS19905	COG1902	pentaerythritol trinitrate reductase activity
B1H19_RS19910	COG1309	transcriptional regulator
B1H19_RS19940	COG0513	Belongs to the DEAD box helicase family
B1H19_RS19990	COG1643	Atp-dependent helicase
B1H19_RS20025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1H19_RS20040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1H19_RS20045	COG0047	phosphoribosylformylglycinamidine synthase activity
B1H19_RS20050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1H19_RS20085	COG2197	response regulator
B1H19_RS20095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1H19_RS20110	COG0151	Belongs to the GarS family
B1H19_RS20125	COG1802	Transcriptional regulator
B1H19_RS20145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1H19_RS20155	COG2197	response regulator
B1H19_RS20170	COG1131	(ABC) transporter
B1H19_RS20175	COG3559	Exporter of polyketide antibiotics
B1H19_RS20180	COG2197	response regulator
B1H19_RS20185	COG4585	Histidine kinase
B1H19_RS20195	COG3844	kynureninase activity
B1H19_RS20200	COG3483	tryptophan 2,3-dioxygenase activity
B1H19_RS20215	COG0191	fructose-bisphosphate aldolase activity
B1H19_RS20220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1H19_RS20235	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1H19_RS20275	COG0542	response to heat
B1H19_RS20295	COG0789	Transcriptional regulator
B1H19_RS20300	COG0484	heat shock protein binding
B1H19_RS20305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1H19_RS20310	COG0443	Heat shock 70 kDa protein
B1H19_RS20315	COG2181	nitrate reductase activity
B1H19_RS20315	COG0247	lactate metabolic process
B1H19_RS20330	COG0328	RNA-DNA hybrid ribonuclease activity
B1H19_RS20365	COG0717	Belongs to the dCTP deaminase family
B1H19_RS20390	COG1141	Ferredoxin
B1H19_RS20405	COG4941	Belongs to the sigma-70 factor family
B1H19_RS20425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B1H19_RS20510	COG2124	cytochrome p450
B1H19_RS20520	COG2318	DinB family
B1H19_RS20540	COG2197	response regulator
B1H19_RS20545	COG4585	Histidine kinase
B1H19_RS20555	COG2301	Belongs to the HpcH HpaI aldolase family
B1H19_RS20570	COG0515	serine threonine protein kinase
B1H19_RS20640	COG1316	TRANSCRIPTIONal
B1H19_RS20715	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B1H19_RS20740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1H19_RS20770	COG2124	cytochrome p450
B1H19_RS20795	COG0745	RESPONSE REGULATOR receiver
B1H19_RS20805	COG1174	glycine betaine transport
B1H19_RS20810	COG1174	glycine betaine transport
B1H19_RS20840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1H19_RS20845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1H19_RS20910	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS20915	COG1362	aminopeptidase activity
B1H19_RS20920	COG3903	Transcriptional regulator
B1H19_RS20920	COG3629	intracellular signal transduction
B1H19_RS20975	COG0494	nUDIX hydrolase
B1H19_RS20985	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1H19_RS20990	COG0022	dehydrogenase e1 component
B1H19_RS21015	COG0515	serine threonine protein kinase
B1H19_RS21020	COG0515	serine threonine protein kinase
B1H19_RS21040	COG0303	'Molybdopterin
B1H19_RS21065	COG1522	sequence-specific DNA binding
B1H19_RS21070	COG1309	transcriptional regulator
B1H19_RS21075	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1H19_RS21125	COG1609	Transcriptional regulator
B1H19_RS21170	COG3396	Phenylacetate-CoA oxygenase
B1H19_RS21175	COG3460	Phenylacetate-CoA oxygenase
B1H19_RS21180	COG3396	Phenylacetate-CoA oxygenase
B1H19_RS21185	COG2151	metal-sulfur cluster biosynthetic enzyme
B1H19_RS21190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1H19_RS21225	COG1733	regulation of RNA biosynthetic process
B1H19_RS21230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1H19_RS21240	COG0583	DNA-binding transcription factor activity
B1H19_RS21250	COG1716	ATPase activity
B1H19_RS21255	COG1716	ATPase activity
B1H19_RS21270	COG0768	penicillin binding
B1H19_RS21275	COG0515	serine threonine protein kinase
B1H19_RS21280	COG3764	Sortase (surface protein transpeptidase)
B1H19_RS21285	COG3764	Sortase (surface protein transpeptidase)
B1H19_RS21295	COG3764	Sortase (surface protein transpeptidase)
B1H19_RS21310	COG0705	Rhomboid family
B1H19_RS21340	COG0515	serine threonine protein kinase
B1H19_RS21370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1H19_RS21375	COG0187	DNA topoisomerase II activity
B1H19_RS21380	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B1H19_RS21385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1H19_RS21390	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B1H19_RS21395	COG0592	DNA-directed DNA polymerase activity
B1H19_RS21410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1H19_RS21415	COG0594	ribonuclease P activity
B1H19_RS21420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1H19_RS21425	COG0706	membrane insertase activity
B1H19_RS21430	COG1847	R3H domain protein
B1H19_RS21435	COG0357	Ribosomal RNA small subunit methyltransferase G
B1H19_RS21440	COG1192	Involved in chromosome partitioning
B1H19_RS21455	COG3118	belongs to the thioredoxin family
B1H19_RS21460	COG0492	ferredoxin-NADP+ reductase activity
B1H19_RS21470	COG1595	DNA-templated transcription, initiation
B1H19_RS21490	COG0617	tRNA 3'-terminal CCA addition
B1H19_RS21510	COG4499	WXG100 protein secretion system (Wss), protein YukC
B1H19_RS21510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1H19_RS21535	COG0360	Binds together with S18 to 16S ribosomal RNA
B1H19_RS21540	COG0629	single-stranded DNA binding
B1H19_RS21545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1H19_RS21550	COG0359	binds to the 23S rRNA
B1H19_RS21560	COG0534	Mate efflux family protein
B1H19_RS21565	COG0305	Participates in initiation and elongation during chromosome replication
B1H19_RS21570	COG0242	peptide deformylase activity
B1H19_RS21590	COG4585	Histidine kinase
B1H19_RS21595	COG2197	response regulator
B1H19_RS21600	COG0789	Transcriptional regulator
B1H19_RS21600	COG4978	Transcriptional regulator
B1H19_RS21615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B1H19_RS21635	COG2814	Major facilitator Superfamily
B1H19_RS21670	COG0626	cystathionine gamma-synthase activity
B1H19_RS21675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1H19_RS21680	COG1950	PFAM Membrane protein of
B1H19_RS21685	COG0662	Cupin 2, conserved barrel domain protein
B1H19_RS21710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1H19_RS21725	COG1609	Transcriptional regulator
B1H19_RS21730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1H19_RS21740	COG1271	oxidase subunit
B1H19_RS21745	COG1294	oxidase, subunit
B1H19_RS21750	COG4988	ABC transporter
B1H19_RS21760	COG0739	heme binding
B1H19_RS21765	COG0561	phosphatase activity
B1H19_RS21775	COG0501	Belongs to the peptidase M48B family
B1H19_RS21785	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B1H19_RS21800	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B1H19_RS21805	COG0789	Transcriptional regulator
B1H19_RS21825	COG1131	(ABC) transporter
B1H19_RS21845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1H19_RS21875	COG0561	phosphatase activity
B1H19_RS21880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1H19_RS21890	COG2837	iron assimilation
B1H19_RS21895	COG2372	response to copper ion
B1H19_RS21935	COG0006	proline dipeptidase activity
B1H19_RS21955	COG0653	protein targeting
B1H19_RS21970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1H19_RS22015	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS22025	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS22040	COG1595	DNA-templated transcription, initiation
B1H19_RS22045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1H19_RS22050	COG3437	response regulator, receiver
B1H19_RS22055	COG3850	Histidine kinase
B1H19_RS22055	COG3437	response regulator, receiver
B1H19_RS22055	COG4999	Histidine kinase
B1H19_RS22055	COG2205	protein histidine kinase activity
B1H19_RS22065	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS22070	COG0784	Response regulator, receiver
B1H19_RS22095	COG2249	NAD(P)H dehydrogenase (quinone) activity
B1H19_RS22115	COG0745	RESPONSE REGULATOR receiver
B1H19_RS22120	COG2205	protein histidine kinase activity
B1H19_RS22130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1H19_RS22135	COG0477	Major facilitator Superfamily
B1H19_RS22195	COG2353	YceI-like domain
B1H19_RS22200	COG0477	Major facilitator Superfamily
B1H19_RS22215	COG2207	Transcriptional regulator
B1H19_RS22215	COG3708	Transcriptional regulator
B1H19_RS22235	COG1191	sigma factor activity
B1H19_RS22240	COG1191	sigma factor activity
B1H19_RS22295	COG2192	nodulation
B1H19_RS22300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1H19_RS22305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1H19_RS22340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1H19_RS22385	COG1064	alcohol dehydrogenase
B1H19_RS22405	COG2268	Band 7 protein
B1H19_RS22425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1H19_RS22430	COG1834	amidinotransferase
B1H19_RS22440	COG2188	Transcriptional regulator
B1H19_RS22445	COG0477	Major facilitator Superfamily
B1H19_RS22450	COG0402	S-adenosylhomocysteine deaminase activity
B1H19_RS22475	COG0277	FAD linked oxidase domain protein
B1H19_RS22490	COG1113	amino acid transport
B1H19_RS22500	COG1132	(ABC) transporter
B1H19_RS22515	COG0154	amidase activity
B1H19_RS22525	COG0745	RESPONSE REGULATOR receiver
B1H19_RS22540	COG2197	response regulator
B1H19_RS22545	COG4585	Histidine kinase
B1H19_RS22550	COG2815	serine threonine protein kinase
B1H19_RS22550	COG0515	serine threonine protein kinase
B1H19_RS22580	COG2226	methyltransferase
B1H19_RS22595	COG0477	Major facilitator Superfamily
B1H19_RS22615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1H19_RS22620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1H19_RS22640	COG1595	DNA-templated transcription, initiation
B1H19_RS22705	COG2319	Wd-40 repeat
B1H19_RS22705	COG4249	Peptidase C14 caspase catalytic subunit p20
B1H19_RS22720	COG1316	TRANSCRIPTIONal
B1H19_RS22735	COG1597	lipid kinase activity
B1H19_RS22750	COG1278	Cold shock
B1H19_RS22755	COG0513	Belongs to the DEAD box helicase family
B1H19_RS22920	COG1408	metallophosphoesterase
B1H19_RS22945	COG0003	Pfam Anion-transporting ATPase
B1H19_RS22970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1H19_RS23005	COG2267	carboxylic ester hydrolase activity
B1H19_RS23015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1H19_RS23020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1H19_RS23025	COG0659	secondary active sulfate transmembrane transporter activity
B1H19_RS23080	COG1205	dead DEAH box helicase
B1H19_RS23080	COG1111	helicase
B1H19_RS23085	COG1366	Belongs to the anti-sigma-factor antagonist family
B1H19_RS23095	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B1H19_RS23105	COG2890	protein-(glutamine-N5) methyltransferase activity
B1H19_RS23130	COG1754	DNA topoisomerase type I activity
B1H19_RS23130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1H19_RS23135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1H19_RS23140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1H19_RS23165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1H19_RS23170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1H19_RS23195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1H19_RS23215	COG3903	Transcriptional regulator
B1H19_RS23215	COG3629	intracellular signal transduction
B1H19_RS23230	COG0584	glycerophosphoryl diester phosphodiesterase
B1H19_RS23235	COG3594	Acyltransferase
B1H19_RS23275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1H19_RS23275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1H19_RS23280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1H19_RS23285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1H19_RS23290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1H19_RS23295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1H19_RS23300	COG0254	rRNA binding
B1H19_RS23310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1H19_RS23330	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS23335	COG2318	DinB family
B1H19_RS23345	COG0076	glutamate decarboxylase activity
B1H19_RS23350	COG0655	NAD(P)H dehydrogenase (quinone) activity
B1H19_RS23355	COG0300	oxidoreductase activity
B1H19_RS23365	COG1595	DNA-templated transcription, initiation
B1H19_RS23395	COG1733	regulation of RNA biosynthetic process
B1H19_RS23405	COG0789	Transcriptional regulator
B1H19_RS23410	COG0393	Putative heavy-metal-binding
B1H19_RS23425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1H19_RS23430	COG2027	D-alanyl-D-alanine carboxypeptidase
B1H19_RS23440	COG0037	tRNA processing
B1H19_RS23455	COG0302	gtp cyclohydrolase
B1H19_RS23465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1H19_RS23465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B1H19_RS23480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1H19_RS23485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1H19_RS23495	COG0517	IMP dehydrogenase activity
B1H19_RS23495	COG1125	glycine betaine transport
B1H19_RS23500	COG1174	glycine betaine transport
B1H19_RS23505	COG1174	glycine betaine transport
B1H19_RS23510	COG1732	Glycine betaine
B1H19_RS23525	COG0649	NAD binding
B1H19_RS23540	COG2197	response regulator
B1H19_RS23545	COG0640	Transcriptional regulator
B1H19_RS23585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1H19_RS23590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1H19_RS23600	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1H19_RS23615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1H19_RS23665	COG2205	protein histidine kinase activity
B1H19_RS23670	COG0745	RESPONSE REGULATOR receiver
B1H19_RS23680	COG1595	DNA-templated transcription, initiation
B1H19_RS23685	COG1194	a g-specific adenine glycosylase
B1H19_RS23705	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B1H19_RS23725	COG0248	Ppx GppA phosphatase
B1H19_RS23730	COG1082	Xylose isomerase domain protein TIM barrel
B1H19_RS23740	COG0129	dihydroxy-acid dehydratase activity
B1H19_RS23770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1H19_RS23770	COG0515	serine threonine protein kinase
B1H19_RS23790	COG1595	DNA-templated transcription, initiation
B1H19_RS23800	COG0659	secondary active sulfate transmembrane transporter activity
B1H19_RS23805	COG1129	ABC transporter
B1H19_RS23805	COG0842	Transport permease protein
B1H19_RS23815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1H19_RS23820	COG0180	Tryptophanyl-tRNA synthetase
B1H19_RS23880	COG1196	nuclear chromosome segregation
B1H19_RS23880	COG0741	lytic transglycosylase activity
B1H19_RS23880	COG0739	heme binding
B1H19_RS23885	COG0671	phosphoesterase, PA-phosphatase related
B1H19_RS23890	COG0277	FAD linked oxidase domain protein
B1H19_RS23905	COG1937	Protein conserved in bacteria
B1H19_RS23915	COG0306	phosphate transporter
B1H19_RS23920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1H19_RS23925	COG0581	inorganic phosphate transmembrane transporter activity
B1H19_RS23965	COG0702	epimerase
B1H19_RS23975	COG0477	Major facilitator Superfamily
B1H19_RS23990	COG2890	protein-(glutamine-N5) methyltransferase activity
B1H19_RS23995	COG0667	Aldo Keto reductase
B1H19_RS24005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1H19_RS24010	COG0431	NADPH-dependent FMN reductase
B1H19_RS24020	COG4552	Acetyltransferase involved in intracellular survival and related
B1H19_RS24035	COG1490	D-aminoacyl-tRNA deacylase activity
B1H19_RS24040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1H19_RS24045	COG0735	belongs to the Fur family
B1H19_RS24055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1H19_RS24060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1H19_RS24065	COG3485	protocatechuate 3,4-dioxygenase
B1H19_RS24085	COG2897	thiosulfate sulfurtransferase activity
B1H19_RS24120	COG0745	RESPONSE REGULATOR receiver
B1H19_RS24125	COG1609	Transcriptional regulator
B1H19_RS24130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1H19_RS24135	COG0745	RESPONSE REGULATOR receiver
B1H19_RS24140	COG2205	protein histidine kinase activity
B1H19_RS24165	COG0737	Belongs to the 5'-nucleotidase family
B1H19_RS24170	COG0456	acetyltransferase
B1H19_RS24220	COG1132	(ABC) transporter
B1H19_RS24225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1H19_RS24235	COG0406	alpha-ribazole phosphatase activity
B1H19_RS24235	COG0494	nUDIX hydrolase
B1H19_RS24250	COG0667	Aldo Keto reductase
B1H19_RS24265	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS24285	COG0588	phosphoglycerate mutase activity
B1H19_RS24300	COG5002	protein histidine kinase activity
B1H19_RS24320	COG1329	Transcriptional regulator
B1H19_RS24325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1H19_RS24330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1H19_RS24340	COG0215	cysteine-tRNA ligase activity
B1H19_RS24365	COG3842	ATPase activity
B1H19_RS24380	COG2197	response regulator
B1H19_RS24425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1H19_RS24455	COG1940	carbohydrate kinase activity
B1H19_RS24460	COG1653	transport
B1H19_RS24475	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B1H19_RS24480	COG0463	Glycosyl transferase, family 2
B1H19_RS24495	COG1278	Cold shock
B1H19_RS24515	COG0583	DNA-binding transcription factor activity
B1H19_RS24545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B1H19_RS24550	COG1737	Transcriptional regulator
B1H19_RS24565	COG1309	transcriptional regulator
B1H19_RS24570	COG2409	Drug exporters of the RND superfamily
B1H19_RS24590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1H19_RS24610	COG3973	AAA domain
B1H19_RS24625	COG1061	Type III restriction enzyme res subunit
B1H19_RS24640	COG0546	phosphoglycolate phosphatase activity
B1H19_RS24650	COG1278	Cold shock
B1H19_RS24655	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B1H19_RS24660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1H19_RS24670	COG2814	Major facilitator Superfamily
B1H19_RS24690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1H19_RS24700	COG2252	PERMEase
B1H19_RS24725	COG0667	Aldo Keto reductase
B1H19_RS24745	COG0477	Major facilitator Superfamily
B1H19_RS24750	COG1733	regulation of RNA biosynthetic process
B1H19_RS24755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1H19_RS24760	COG2378	regulation of single-species biofilm formation
B1H19_RS24770	COG0277	FAD linked oxidase domain protein
B1H19_RS24770	COG0247	lactate metabolic process
B1H19_RS24815	COG0583	DNA-binding transcription factor activity
B1H19_RS24820	COG5006	permease, DMT superfamily
B1H19_RS24835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1H19_RS24850	COG1024	Enoyl-CoA hydratase
B1H19_RS24865	COG0259	pyridoxamine-phosphate oxidase activity
B1H19_RS24875	COG4821	SIS domain
B1H19_RS24915	COG1131	(ABC) transporter
B1H19_RS24970	COG2197	response regulator
B1H19_RS24990	COG0515	serine threonine protein kinase
B1H19_RS24995	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS25015	COG0519	Catalyzes the synthesis of GMP from XMP
B1H19_RS25015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1H19_RS25025	COG2084	Dehydrogenase
B1H19_RS25065	COG0515	serine threonine protein kinase
B1H19_RS25065	COG2815	serine threonine protein kinase
B1H19_RS25075	COG2197	response regulator
B1H19_RS25115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS25130	COG0714	Associated with various cellular activities
B1H19_RS25135	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B1H19_RS25140	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B1H19_RS25160	COG0045	succinate-CoA ligase (ADP-forming) activity
B1H19_RS25185	COG0138	bifunctional purine biosynthesis protein purh
B1H19_RS25205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1H19_RS25215	COG0538	isocitrate dehydrogenase activity
B1H19_RS25220	COG0039	L-malate dehydrogenase activity
B1H19_RS25260	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS25270	COG0517	IMP dehydrogenase activity
B1H19_RS25270	COG4175	Glycine betaine
B1H19_RS25275	COG4176	ABC-type proline glycine betaine transport system permease component
B1H19_RS25300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1H19_RS25305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1H19_RS25310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1H19_RS25335	COG2226	methyltransferase
B1H19_RS25340	COG2226	methyltransferase
B1H19_RS25360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1H19_RS25365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1H19_RS25370	COG0180	Tryptophanyl-tRNA synthetase
B1H19_RS25380	COG1295	ribonuclease BN
B1H19_RS25385	COG1686	Belongs to the peptidase S11 family
B1H19_RS25395	COG1408	metallophosphoesterase
B1H19_RS25450	COG1053	succinate dehydrogenase
B1H19_RS25460	COG2009	succinate dehydrogenase
B1H19_RS25475	COG1595	DNA-templated transcription, initiation
B1H19_RS25485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS25485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS25500	COG3265	gluconokinase activity
B1H19_RS25575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1H19_RS25585	COG1216	Glycosyl transferase, family 2
B1H19_RS25595	COG1083	cytidylyl-transferase
B1H19_RS25600	COG2089	acid synthase
B1H19_RS25610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1H19_RS25610	COG1473	amidohydrolase
B1H19_RS25615	COG1744	ABC transporter substrate-binding protein PnrA-like
B1H19_RS25620	COG3845	ABC transporter
B1H19_RS25625	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1H19_RS25630	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1H19_RS25660	COG2814	Major facilitator Superfamily
B1H19_RS25665	COG0583	DNA-binding transcription factor activity
B1H19_RS25675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1H19_RS25700	COG2205	protein histidine kinase activity
B1H19_RS25705	COG0745	RESPONSE REGULATOR receiver
B1H19_RS25710	COG1595	DNA-templated transcription, initiation
B1H19_RS25725	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS25730	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS25755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1H19_RS25795	COG4770	biotin carboxylase activity
B1H19_RS25810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1H19_RS25810	COG0515	serine threonine protein kinase
B1H19_RS25820	COG0693	protein deglycase activity
B1H19_RS25825	COG0424	maF-like protein
B1H19_RS25830	COG0768	penicillin binding
B1H19_RS25840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1H19_RS25850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B1H19_RS25855	COG1024	Enoyl-CoA hydratase
B1H19_RS25865	COG2986	histidine ammonia-lyase
B1H19_RS25880	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS25910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1H19_RS25915	COG0798	PFAM Bile acid sodium symporter
B1H19_RS25920	COG0640	Transcriptional regulator
B1H19_RS25930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1H19_RS25945	COG2255	four-way junction helicase activity
B1H19_RS25950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1H19_RS25965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1H19_RS25975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1H19_RS25990	COG1331	Highly conserved protein containing a thioredoxin domain
B1H19_RS26000	COG0154	amidase activity
B1H19_RS26015	COG0477	Major facilitator Superfamily
B1H19_RS26025	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B1H19_RS26035	COG0436	Aminotransferase
B1H19_RS26045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B1H19_RS26060	COG1414	Transcriptional regulator
B1H19_RS26065	COG0251	oxidation-reduction process
B1H19_RS26070	COG2610	gluconate transmembrane transporter activity
B1H19_RS26145	COG0667	Aldo Keto reductase
B1H19_RS26150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1H19_RS26155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1H19_RS26160	COG0741	lytic transglycosylase activity
B1H19_RS26170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1H19_RS26175	COG0450	alkyl hydroperoxide reductase
B1H19_RS26190	COG1136	(ABC) transporter
B1H19_RS26240	COG0114	fumarate hydratase activity
B1H19_RS26250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B1H19_RS26250	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B1H19_RS26275	COG0778	Nitroreductase
B1H19_RS26280	COG1722	exodeoxyribonuclease VII activity
B1H19_RS26285	COG1570	exodeoxyribonuclease VII activity
B1H19_RS26295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1H19_RS26310	COG0012	GTP binding
B1H19_RS26325	COG2267	carboxylic ester hydrolase activity
B1H19_RS26340	COG0531	amino acid
B1H19_RS26365	COG0402	S-adenosylhomocysteine deaminase activity
B1H19_RS26375	COG1053	succinate dehydrogenase
B1H19_RS26395	COG1217	gtp-binding protein TYPA
B1H19_RS26445	COG0747	negative chemotaxis
B1H19_RS26450	COG0601	transmembrane transport
B1H19_RS26455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1H19_RS26465	COG4608	Belongs to the ABC transporter superfamily
B1H19_RS26470	COG4608	Belongs to the ABC transporter superfamily
B1H19_RS26475	COG0444	Belongs to the ABC transporter superfamily
B1H19_RS26480	COG0601	transmembrane transport
B1H19_RS26485	COG4166	transmembrane transport
B1H19_RS26490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1H19_RS26510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1H19_RS26525	COG1131	(ABC) transporter
B1H19_RS26535	COG4585	Histidine kinase
B1H19_RS26550	COG2197	response regulator
B1H19_RS26590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1H19_RS26595	COG1611	Belongs to the LOG family
B1H19_RS26600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1H19_RS26610	COG0519	Catalyzes the synthesis of GMP from XMP
B1H19_RS26615	COG1024	Enoyl-CoA hydratase
B1H19_RS26630	COG1595	DNA-templated transcription, initiation
B1H19_RS26640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1H19_RS26645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1H19_RS26680	COG0598	Magnesium transport protein CorA
B1H19_RS26695	COG0613	PHP domain protein
B1H19_RS26700	COG2095	MarC family integral membrane protein
B1H19_RS26705	COG1432	Conserved Protein
B1H19_RS26715	COG0513	Belongs to the DEAD box helicase family
B1H19_RS26745	COG0596	Alpha beta hydrolase
B1H19_RS26745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1H19_RS26795	COG0210	DNA helicase
B1H19_RS26800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1H19_RS26840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1H19_RS26895	COG3480	Lon protease (S16) C-terminal proteolytic domain
B1H19_RS26905	COG1615	UPF0182 protein
B1H19_RS26930	COG0753	catalase activity
B1H19_RS26940	COG0483	inositol monophosphate 1-phosphatase activity
B1H19_RS26950	COG2076	Multidrug Resistance protein
B1H19_RS26955	COG1162	GTPase activity
B1H19_RS26960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1H19_RS26970	COG2135	peptidase activity
B1H19_RS26980	COG1595	DNA-templated transcription, initiation
B1H19_RS26985	COG5662	AntiSigma factor
B1H19_RS27005	COG0242	peptide deformylase activity
B1H19_RS27010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1H19_RS27015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1H19_RS27035	COG2188	Transcriptional regulator
B1H19_RS27040	COG2182	Extracellular solute-binding protein
B1H19_RS27045	COG1175	transmembrane transport
B1H19_RS27050	COG0395	ABC-type sugar transport system, permease component
B1H19_RS27055	COG1472	Belongs to the glycosyl hydrolase 3 family
B1H19_RS27060	COG0363	glucosamine-6-phosphate deaminase activity
B1H19_RS27065	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS27070	COG1309	transcriptional regulator
B1H19_RS27085	COG1597	lipid kinase activity
B1H19_RS27120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B1H19_RS27135	COG2066	Belongs to the glutaminase family
B1H19_RS27145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1H19_RS27160	COG0598	Magnesium transport protein CorA
B1H19_RS27165	COG2807	transmembrane transport
B1H19_RS27170	COG2186	Transcriptional regulator
B1H19_RS27175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1H19_RS27180	COG1993	acr, cog1993
B1H19_RS27185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1H19_RS27205	COG1280	lysine exporter protein (LysE YggA)
B1H19_RS27210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1H19_RS27240	COG4106	trans-aconitate 2-methyltransferase activity
B1H19_RS27245	COG1126	abc transporter atp-binding protein
B1H19_RS27260	COG0281	malic enzyme
B1H19_RS27265	COG0604	alcohol dehydrogenase
B1H19_RS27290	COG0567	Dehydrogenase, E1 component
B1H19_RS27290	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1H19_RS27295	COG2205	protein histidine kinase activity
B1H19_RS27300	COG0745	RESPONSE REGULATOR receiver
B1H19_RS27320	COG1357	PFAM Pentapeptide repeats (8 copies)
B1H19_RS27325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1H19_RS27345	COG5002	protein histidine kinase activity
B1H19_RS27405	COG1119	ATPase activity
B1H19_RS27415	COG0768	penicillin binding
B1H19_RS27430	COG2124	cytochrome p450
B1H19_RS27445	COG0018	arginyl-trna synthetase
B1H19_RS27450	COG0019	diaminopimelate decarboxylase activity
B1H19_RS27455	COG0460	homoserine dehydrogenase
B1H19_RS27460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1H19_RS27465	COG0083	homoserine kinase activity
B1H19_RS27480	COG0254	rRNA binding
B1H19_RS27485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1H19_RS27490	COG2890	protein-(glutamine-N5) methyltransferase activity
B1H19_RS27500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1H19_RS27505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1H19_RS27525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1H19_RS27530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1H19_RS27535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1H19_RS27540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1H19_RS27545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1H19_RS27550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1H19_RS27555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1H19_RS27565	COG2197	response regulator
B1H19_RS27570	COG4585	Histidine kinase
B1H19_RS27595	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1H19_RS27610	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B1H19_RS27665	COG0183	Belongs to the thiolase family
B1H19_RS27715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS27715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS27720	COG2205	protein histidine kinase activity
B1H19_RS27725	COG0745	RESPONSE REGULATOR receiver
B1H19_RS27730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1H19_RS27735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1H19_RS27775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B1H19_RS27780	COG0857	belongs to the CobB CobQ family
B1H19_RS27780	COG0280	phosphate acetyltransferase
B1H19_RS27785	COG0205	6-phosphofructokinase activity
B1H19_RS27790	COG0577	efflux transmembrane transporter activity
B1H19_RS27795	COG0577	efflux transmembrane transporter activity
B1H19_RS27795	COG1136	(ABC) transporter
B1H19_RS27805	COG4565	transcriptional regulatory protein
B1H19_RS27810	COG3290	protein histidine kinase activity
B1H19_RS27815	COG1301	dicarboxylic acid transport
B1H19_RS27835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1H19_RS27840	COG3281	Trehalose synthase
B1H19_RS27845	COG0366	Alpha amylase catalytic
B1H19_RS27850	COG0366	Alpha amylase catalytic
B1H19_RS27865	COG1132	(ABC) transporter
B1H19_RS27870	COG1132	(ABC) transporter
B1H19_RS27880	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS27885	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS27905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1H19_RS27905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1H19_RS27910	COG0785	Cytochrome C biogenesis protein
B1H19_RS27920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1H19_RS27935	COG0745	RESPONSE REGULATOR receiver
B1H19_RS27940	COG2205	protein histidine kinase activity
B1H19_RS27955	COG0671	phosphoesterase, PA-phosphatase related
B1H19_RS27960	COG0671	phosphoesterase, PA-phosphatase related
B1H19_RS27975	COG1760	l-serine dehydratase
B1H19_RS27980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1H19_RS27985	COG0509	glycine decarboxylation via glycine cleavage system
B1H19_RS27990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1H19_RS28010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1H19_RS28015	COG0747	negative chemotaxis
B1H19_RS28020	COG0601	transmembrane transport
B1H19_RS28025	COG0444	Belongs to the ABC transporter superfamily
B1H19_RS28030	COG4608	Belongs to the ABC transporter superfamily
B1H19_RS28040	COG2860	membrane
B1H19_RS28080	COG0482	sulfurtransferase activity
B1H19_RS28090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1H19_RS28100	COG4221	oxidoreductase activity
B1H19_RS28120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1H19_RS28130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1H19_RS28135	COG0154	amidase activity
B1H19_RS28145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1H19_RS28175	COG2409	Drug exporters of the RND superfamily
B1H19_RS28190	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B1H19_RS28190	COG1672	PFAM Archaeal ATPase
B1H19_RS28200	COG2133	pyrroloquinoline quinone binding
B1H19_RS28205	COG0656	L-ascorbic acid biosynthetic process
B1H19_RS28215	COG3300	MHYT domain
B1H19_RS28215	COG5001	Diguanylate cyclase
B1H19_RS28225	COG0440	acetolactate synthase activity
B1H19_RS28230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1H19_RS28235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1H19_RS28245	COG3835	regulator
B1H19_RS28250	COG0506	proline dehydrogenase activity
B1H19_RS28255	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS28265	COG0575	Belongs to the CDS family
B1H19_RS28280	COG0473	3-isopropylmalate dehydrogenase activity
B1H19_RS28285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1H19_RS28295	COG0832	Belongs to the urease beta subunit family
B1H19_RS28295	COG0831	urea catabolic process
B1H19_RS28300	COG0804	urea catabolic process
B1H19_RS28305	COG2957	Belongs to the agmatine deiminase family
B1H19_RS28310	COG1309	transcriptional regulator
B1H19_RS28315	COG0477	Major facilitator Superfamily
B1H19_RS28320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1H19_RS28325	COG2353	YceI-like domain
B1H19_RS28330	COG5492	domain, Protein
B1H19_RS28335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1H19_RS28360	COG2018	Roadblock/LC7 domain
B1H19_RS28380	COG2018	Roadblock/LC7 domain
B1H19_RS28395	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1H19_RS28400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1H19_RS28445	COG1414	Transcriptional regulator
B1H19_RS28450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1H19_RS28455	COG0066	3-isopropylmalate dehydratase activity
B1H19_RS28465	COG0776	regulation of translation
B1H19_RS28475	COG1920	GTP binding
B1H19_RS28485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1H19_RS28490	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1H19_RS28510	COG0351	phosphomethylpyrimidine kinase
B1H19_RS28515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1H19_RS28520	COG1461	Dihydroxyacetone kinase
B1H19_RS28530	COG0742	ribosomal rna small subunit methyltransferase
B1H19_RS28535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1H19_RS28550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1H19_RS28555	COG0571	ribonuclease III activity
B1H19_RS28560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1H19_RS28570	COG1254	Belongs to the acylphosphatase family
B1H19_RS28580	COG1196	nuclear chromosome segregation
B1H19_RS28585	COG0477	Major facilitator Superfamily
B1H19_RS28600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B1H19_RS28630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B1H19_RS28650	COG0228	four-way junction DNA binding
B1H19_RS28655	COG1837	Belongs to the UPF0109 family
B1H19_RS28660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1H19_RS28665	COG0336	Belongs to the RNA methyltransferase TrmD family
B1H19_RS28670	COG0335	large ribosomal subunit rRNA binding
B1H19_RS28675	COG0681	Belongs to the peptidase S26 family
B1H19_RS28685	COG0681	Belongs to the peptidase S26 family
B1H19_RS28690	COG0681	Belongs to the peptidase S26 family
B1H19_RS28705	COG0792	nuclease activity
B1H19_RS28720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1H19_RS28725	COG0494	nUDIX hydrolase
B1H19_RS28730	COG0367	asparagine synthase
B1H19_RS28865	COG1191	sigma factor activity
B1H19_RS28880	COG0052	Belongs to the universal ribosomal protein uS2 family
B1H19_RS28885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1H19_RS28890	COG0528	UMP kinase activity
B1H19_RS28895	COG0233	cytoplasmic translational termination
B1H19_RS28905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1H19_RS28915	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B1H19_RS28920	COG3842	ATPase activity
B1H19_RS28950	COG1136	(ABC) transporter
B1H19_RS28955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1H19_RS28965	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS28985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1H19_RS28995	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS29005	COG3842	ATPase activity
B1H19_RS29010	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1H19_RS29015	COG1177	transmembrane transport
B1H19_RS29020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1H19_RS29045	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS29060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1H19_RS29065	COG0750	zinc metalloprotease
B1H19_RS29070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1H19_RS29085	COG0442	prolyl-tRNA aminoacylation
B1H19_RS29105	COG0779	Required for maturation of 30S ribosomal subunits
B1H19_RS29120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1H19_RS29130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1H19_RS29135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1H19_RS29150	COG0455	bacterial-type flagellum organization
B1H19_RS29270	COG1674	ftsk spoiiie
B1H19_RS29280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1H19_RS29285	COG1185	polyribonucleotide nucleotidyltransferase activity
B1H19_RS29290	COG0612	Peptidase, M16
B1H19_RS29295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1H19_RS29315	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B1H19_RS29320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1H19_RS29325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B1H19_RS29360	COG2208	phosphoserine phosphatase activity
B1H19_RS29360	COG2770	Histidine kinase
B1H19_RS29365	COG4999	Histidine kinase
B1H19_RS29365	COG3850	Histidine kinase
B1H19_RS29365	COG3437	response regulator, receiver
B1H19_RS29365	COG2205	protein histidine kinase activity
B1H19_RS29375	COG1674	ftsk spoiiie
B1H19_RS29385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1H19_RS29395	COG1058	Belongs to the CinA family
B1H19_RS29395	COG1546	Belongs to the CinA family
B1H19_RS29400	COG1396	sequence-specific DNA binding
B1H19_RS29405	COG0783	Belongs to the Dps family
B1H19_RS29415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1H19_RS29420	COG1201	RNA secondary structure unwinding
B1H19_RS29450	COG0628	permease
B1H19_RS29465	COG1309	transcriptional regulator
B1H19_RS29500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS29505	COG0765	amino acid transport
B1H19_RS29510	COG0765	amino acid transport
B1H19_RS29520	COG1126	abc transporter atp-binding protein
B1H19_RS29530	COG2205	protein histidine kinase activity
B1H19_RS29535	COG1278	Cold shock
B1H19_RS29570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1H19_RS29580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1H19_RS29595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1H19_RS29605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1H19_RS29610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1H19_RS29620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1H19_RS29655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1H19_RS29660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1H19_RS29665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1H19_RS29695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1H19_RS29730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B1H19_RS29735	COG2186	Transcriptional regulator
B1H19_RS29740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1H19_RS29755	COG0187	DNA topoisomerase II activity
B1H19_RS29765	COG4585	Histidine kinase
B1H19_RS29770	COG2197	response regulator
B1H19_RS29780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1H19_RS29795	COG0372	Belongs to the citrate synthase family
B1H19_RS29805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1H19_RS29810	COG0612	Peptidase, M16
B1H19_RS29825	COG1802	Transcriptional regulator
B1H19_RS29830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1H19_RS29835	COG0045	succinate-CoA ligase (ADP-forming) activity
B1H19_RS29835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1H19_RS29835	COG1042	CoA-binding domain protein
B1H19_RS29850	COG1435	thymidine kinase activity
B1H19_RS29875	COG4221	oxidoreductase activity
B1H19_RS29890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1H19_RS29895	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1H19_RS29920	COG1435	thymidine kinase activity
B1H19_RS29920	COG1435	thymidine kinase activity
B1H19_RS29970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1H19_RS29975	COG0483	inositol monophosphate 1-phosphatase activity
B1H19_RS29980	COG0745	RESPONSE REGULATOR receiver
B1H19_RS29985	COG2205	protein histidine kinase activity
B1H19_RS30010	COG0756	dUTP diphosphatase activity
B1H19_RS30025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B1H19_RS30030	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B1H19_RS30035	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B1H19_RS30070	COG0569	domain protein
B1H19_RS30080	COG0531	amino acid
B1H19_RS30085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1H19_RS30115	COG1201	RNA secondary structure unwinding
B1H19_RS30160	COG0702	epimerase
B1H19_RS30180	COG1846	Transcriptional regulator
B1H19_RS30210	COG2124	cytochrome p450
B1H19_RS30230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1H19_RS30240	COG1231	oxidoreductase activity
B1H19_RS30295	COG0789	Transcriptional regulator
B1H19_RS30310	COG1799	cell septum assembly
B1H19_RS30340	COG4977	sequence-specific DNA binding
B1H19_RS30355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1H19_RS30360	COG0531	amino acid
B1H19_RS30370	COG1024	Enoyl-CoA hydratase
B1H19_RS30385	COG3321	synthase
B1H19_RS30385	COG0604	alcohol dehydrogenase
B1H19_RS30385	COG4221	oxidoreductase activity
B1H19_RS30385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1H19_RS30395	COG0546	phosphoglycolate phosphatase activity
B1H19_RS30420	COG1349	DNA-binding transcription factor activity
B1H19_RS30430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1H19_RS30435	COG1595	DNA-templated transcription, initiation
B1H19_RS30445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1H19_RS30460	COG1653	transport
B1H19_RS30465	COG1175	transmembrane transport
B1H19_RS30470	COG0395	ABC-type sugar transport system, permease component
B1H19_RS30475	COG1940	carbohydrate kinase activity
B1H19_RS30480	COG4213	ABC transporter substrate-binding protein
B1H19_RS30490	COG4214	carbohydrate transport
B1H19_RS30495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1H19_RS30500	COG0531	amino acid
B1H19_RS30515	COG0183	Belongs to the thiolase family
B1H19_RS30520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B1H19_RS30545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1H19_RS30550	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1H19_RS30555	COG0183	Belongs to the thiolase family
B1H19_RS30560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1H19_RS30565	COG3253	May function as heme-dependent peroxidase
B1H19_RS30630	COG1136	(ABC) transporter
B1H19_RS30640	COG4585	Histidine kinase
B1H19_RS30645	COG2197	response regulator
B1H19_RS30650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1H19_RS30655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1H19_RS30660	COG4565	transcriptional regulatory protein
B1H19_RS30665	COG3290	protein histidine kinase activity
B1H19_RS30670	COG1116	anion transmembrane transporter activity
B1H19_RS30675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1H19_RS30685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1H19_RS30705	COG2205	protein histidine kinase activity
B1H19_RS30710	COG0745	RESPONSE REGULATOR receiver
B1H19_RS30715	COG0477	Major facilitator Superfamily
B1H19_RS30730	COG2197	response regulator
B1H19_RS30735	COG3321	synthase
B1H19_RS30735	COG0604	alcohol dehydrogenase
B1H19_RS30740	COG0604	alcohol dehydrogenase
B1H19_RS30740	COG3321	synthase
B1H19_RS30760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1H19_RS30795	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS30810	COG4770	biotin carboxylase activity
B1H19_RS30825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1H19_RS30830	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS30845	COG0456	acetyltransferase
B1H19_RS30865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1H19_RS30920	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS30975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1H19_RS30980	COG0546	phosphoglycolate phosphatase activity
B1H19_RS30985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1H19_RS31040	COG3547	Transposase (IS116 IS110 IS902 family)
B1H19_RS31060	COG1917	Cupin 2, conserved barrel domain protein
B1H19_RS31065	COG2124	cytochrome p450
B1H19_RS31080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS31150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1H19_RS31150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1H19_RS31170	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS31215	COG3261	NADH dehydrogenase
B1H19_RS31215	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B1H19_RS31220	COG0651	ATP synthesis coupled electron transport
B1H19_RS31230	COG0650	Formate hydrogenlyase subunit 4
B1H19_RS31240	COG3260	NADH ubiquinone oxidoreductase 20
B1H19_RS31300	COG0659	secondary active sulfate transmembrane transporter activity
B1H19_RS31310	COG2824	Alkylphosphonate utilization operon protein PhnA
B1H19_RS31385	COG0641	radical SAM
B1H19_RS31475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1H19_RS31480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B1H19_RS31500	COG0529	Catalyzes the synthesis of activated sulfate
B1H19_RS31505	COG0175	sulfate reduction
B1H19_RS31540	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS31600	COG2080	2 iron, 2 sulfur cluster binding
B1H19_RS31605	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1H19_RS31610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS31630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1H19_RS31640	COG3511	phospholipase C
B1H19_RS31655	COG1376	ErfK ybiS ycfS ynhG family protein
B1H19_RS31685	COG1716	ATPase activity
B1H19_RS31685	COG1131	(ABC) transporter
B1H19_RS31685	COG0842	Transport permease protein
B1H19_RS31690	COG2233	PERMEase
B1H19_RS31705	COG2755	lipolytic protein G-D-S-L family
B1H19_RS31705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1H19_RS31710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS31710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS31715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1H19_RS31720	COG3290	protein histidine kinase activity
B1H19_RS31730	COG0454	-acetyltransferase
B1H19_RS31795	COG1162	GTPase activity
B1H19_RS31815	COG0028	Belongs to the TPP enzyme family
B1H19_RS31835	COG1802	Transcriptional regulator
B1H19_RS31865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS31870	COG2252	PERMEase
B1H19_RS31880	COG4552	Acetyltransferase involved in intracellular survival and related
B1H19_RS31885	COG0583	DNA-binding transcription factor activity
B1H19_RS31895	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS31900	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS31910	COG2315	Protein conserved in bacteria
B1H19_RS31925	COG0753	catalase activity
B1H19_RS31930	COG2084	Dehydrogenase
B1H19_RS31935	COG3622	Belongs to the hyi family
B1H19_RS31955	COG2351	hydroxyisourate hydrolase activity
B1H19_RS31965	COG2233	PERMEase
B1H19_RS31975	COG2233	PERMEase
B1H19_RS31990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B1H19_RS32015	COG1414	Transcriptional regulator
B1H19_RS32020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1H19_RS32025	COG4266	Belongs to the allantoicase family
B1H19_RS32045	COG0800	Aldolase
B1H19_RS32060	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS32065	COG2188	Transcriptional regulator
B1H19_RS32080	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1H19_RS32090	COG1940	carbohydrate kinase activity
B1H19_RS32100	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1H19_RS32105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1H19_RS32130	COG1126	abc transporter atp-binding protein
B1H19_RS32135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1H19_RS32140	COG0765	amino acid transport
B1H19_RS32145	COG0765	amino acid transport
B1H19_RS32165	COG0435	Glutathione S-transferase
B1H19_RS32185	COG0387	Pfam Sodium calcium exchanger
B1H19_RS32195	COG0405	Gamma-glutamyltransferase
B1H19_RS32205	COG1335	isochorismatase
B1H19_RS32210	COG0477	Major facilitator Superfamily
B1H19_RS32230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1H19_RS32240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1H19_RS32245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS32250	COG1953	Uracil, thiamine, allantoin
B1H19_RS32265	COG4977	sequence-specific DNA binding
B1H19_RS32280	COG1733	regulation of RNA biosynthetic process
B1H19_RS32335	COG0095	Lipoate-protein ligase
B1H19_RS32345	COG3467	pyridoxamine 5'-phosphate
B1H19_RS32395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1H19_RS32405	COG0483	inositol monophosphate 1-phosphatase activity
B1H19_RS32415	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B1H19_RS32460	COG1929	Belongs to the glycerate kinase type-1 family
B1H19_RS32470	COG0688	phosphatidylethanolamine metabolic process
B1H19_RS32475	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS32485	COG2301	Belongs to the HpcH HpaI aldolase family
B1H19_RS32490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS32490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1H19_RS32495	COG0604	alcohol dehydrogenase
B1H19_RS32505	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1H19_RS32535	COG0667	Aldo Keto reductase
B1H19_RS32545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1H19_RS32550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1H19_RS32560	COG0395	ABC-type sugar transport system, permease component
B1H19_RS32565	COG1175	transmembrane transport
B1H19_RS32570	COG1653	transport
B1H19_RS32575	COG0366	Alpha amylase catalytic
B1H19_RS32580	COG1653	transport
B1H19_RS32590	COG1136	(ABC) transporter
B1H19_RS32610	COG2362	D-Aminopeptidase
B1H19_RS32620	COG4946	Tricorn protease homolog
B1H19_RS32620	COG0823	Involved in the tonB-independent uptake of proteins
B1H19_RS32620	COG1506	peptidase
B1H19_RS32635	COG2124	cytochrome p450
B1H19_RS32650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1H19_RS32665	COG0604	alcohol dehydrogenase
B1H19_RS32675	COG2226	methyltransferase
B1H19_RS32680	COG1597	lipid kinase activity
B1H19_RS32690	COG3424	synthase
B1H19_RS32705	COG0531	amino acid
B1H19_RS32735	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1H19_RS32740	COG1295	ribonuclease BN
B1H19_RS32755	COG3903	Transcriptional regulator
B1H19_RS32755	COG3629	intracellular signal transduction
B1H19_RS32770	COG0656	L-ascorbic acid biosynthetic process
B1H19_RS32780	COG0583	DNA-binding transcription factor activity
B1H19_RS32805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B1H19_RS32810	COG0287	Prephenate dehydrogenase
B1H19_RS32810	COG1605	Chorismate mutase
B1H19_RS32820	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS32840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1H19_RS32845	COG1518	maintenance of DNA repeat elements
B1H19_RS32860	COG1857	crispr-associated protein
B1H19_RS32915	COG3547	Transposase (IS116 IS110 IS902 family)
B1H19_RS32995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1H19_RS33045	COG2264	protein methyltransferase activity
B1H19_RS33055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1H19_RS33060	COG2271	Major facilitator Superfamily
B1H19_RS33070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1H19_RS33080	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS33100	COG0529	Catalyzes the synthesis of activated sulfate
B1H19_RS33145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1H19_RS33155	COG1316	TRANSCRIPTIONal
B1H19_RS33165	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS33225	COG3963	phosphatidate phosphatase activity
B1H19_RS33235	COG0604	alcohol dehydrogenase
B1H19_RS33235	COG3321	synthase
B1H19_RS33235	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS33290	COG0657	acetylesterase activity
B1H19_RS33300	COG2814	Major facilitator Superfamily
B1H19_RS33305	COG0438	transferase activity, transferring glycosyl groups
B1H19_RS33325	COG0745	RESPONSE REGULATOR receiver
B1H19_RS33365	COG0277	FAD linked oxidase domain protein
B1H19_RS33420	COG2132	Multicopper oxidase
B1H19_RS33435	COG0583	DNA-binding transcription factor activity
B1H19_RS33450	COG0028	Belongs to the TPP enzyme family
B1H19_RS33465	COG2814	Major facilitator Superfamily
B1H19_RS33470	COG1733	regulation of RNA biosynthetic process
B1H19_RS33485	COG0789	Transcriptional regulator
B1H19_RS33495	COG2318	DinB family
B1H19_RS33510	COG3629	intracellular signal transduction
B1H19_RS33510	COG3903	Transcriptional regulator
B1H19_RS33535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1H19_RS33565	COG2814	Major facilitator Superfamily
B1H19_RS33570	COG0583	DNA-binding transcription factor activity
B1H19_RS33590	COG3938	Belongs to the proline racemase family
B1H19_RS33610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1H19_RS33615	COG0747	negative chemotaxis
B1H19_RS33620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1H19_RS33625	COG0601	transmembrane transport
B1H19_RS33635	COG4608	Belongs to the ABC transporter superfamily
B1H19_RS33640	COG1473	amidohydrolase
B1H19_RS33655	COG1231	oxidoreductase activity
B1H19_RS33675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1H19_RS33685	COG0745	RESPONSE REGULATOR receiver
B1H19_RS33700	COG0745	RESPONSE REGULATOR receiver
B1H19_RS33725	COG2205	protein histidine kinase activity
B1H19_RS33765	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
B1H19_RS33830	COG3291	Pkd domain containing protein
B1H19_RS33835	COG0583	DNA-binding transcription factor activity
B1H19_RS33840	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS33850	COG0640	Transcriptional regulator
B1H19_RS33855	COG2814	Major facilitator Superfamily
B1H19_RS33880	COG1113	amino acid transport
B1H19_RS33890	COG0477	Major facilitator Superfamily
B1H19_RS33945	COG1132	(ABC) transporter
B1H19_RS33950	COG0515	serine threonine protein kinase
B1H19_RS33950	COG2815	serine threonine protein kinase
B1H19_RS33955	COG3629	intracellular signal transduction
B1H19_RS33955	COG3903	Transcriptional regulator
B1H19_RS33970	COG2197	response regulator
B1H19_RS33975	COG4585	Histidine kinase
B1H19_RS34015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1H19_RS34080	COG2205	protein histidine kinase activity
B1H19_RS34085	COG0745	RESPONSE REGULATOR receiver
B1H19_RS34100	COG2197	response regulator
B1H19_RS34120	COG3226	Transcriptional regulator
B1H19_RS34145	COG1309	transcriptional regulator
B1H19_RS34155	COG1349	DNA-binding transcription factor activity
B1H19_RS34165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1H19_RS34170	COG2814	Major facilitator Superfamily
B1H19_RS34185	COG1515	deoxyribonuclease V activity
B1H19_RS34190	COG3268	Saccharopine dehydrogenase
B1H19_RS34200	COG1285	pathogenesis
B1H19_RS34210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1H19_RS34215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS34220	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS34225	COG0183	Belongs to the thiolase family
B1H19_RS34230	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1H19_RS34230	COG1024	Enoyl-CoA hydratase
B1H19_RS34245	COG1113	amino acid transport
B1H19_RS34260	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS34270	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS34305	COG2378	regulation of single-species biofilm formation
B1H19_RS34315	COG2936	dipeptidyl-peptidase activity
B1H19_RS34330	COG1401	restriction endodeoxyribonuclease activity
B1H19_RS34340	COG2183	response to ionizing radiation
B1H19_RS34350	COG4977	sequence-specific DNA binding
B1H19_RS34360	COG1024	Enoyl-CoA hydratase
B1H19_RS34380	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B1H19_RS34415	COG1134	teichoic acid transport
B1H19_RS34420	COG1562	ergosterol biosynthetic process
B1H19_RS34430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1H19_RS34440	COG1657	PFAM Prenyltransferase squalene oxidase
B1H19_RS34455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1H19_RS34465	COG2365	Tyrosine phosphatase family
B1H19_RS34470	COG2755	lipolytic protein G-D-S-L family
B1H19_RS34520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1H19_RS34575	COG2018	Roadblock/LC7 domain
B1H19_RS34595	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS34605	COG2267	carboxylic ester hydrolase activity
B1H19_RS34640	COG1686	Belongs to the peptidase S11 family
B1H19_RS34665	COG0174	glutamine synthetase
B1H19_RS34675	COG0477	Major facilitator Superfamily
B1H19_RS34740	COG1024	Enoyl-CoA hydratase
B1H19_RS34745	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS34755	COG1652	LysM domain
B1H19_RS34845	COG3537	Alpha-1,2-mannosidase
B1H19_RS34850	COG0531	amino acid
B1H19_RS34895	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B1H19_RS34905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1H19_RS34910	COG3572	ergothioneine biosynthetic process
B1H19_RS34940	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS34945	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS34975	COG1349	DNA-binding transcription factor activity
B1H19_RS34980	COG2814	Major facilitator Superfamily
B1H19_RS34990	COG1070	Carbohydrate kinase
B1H19_RS34995	COG0588	phosphoglycerate mutase activity
B1H19_RS35000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1H19_RS35005	COG3511	phospholipase C
B1H19_RS35020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B1H19_RS35020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1H19_RS35040	COG3023	N-Acetylmuramoyl-L-alanine amidase
B1H19_RS35045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS35045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS35050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1H19_RS35060	COG1070	Carbohydrate kinase
B1H19_RS35065	COG2115	Belongs to the xylose isomerase family
B1H19_RS35075	COG1126	abc transporter atp-binding protein
B1H19_RS35080	COG0765	amino acid transport
B1H19_RS35085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1H19_RS35105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1H19_RS35125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1H19_RS35145	COG2226	methyltransferase
B1H19_RS35165	COG2018	Roadblock/LC7 domain
B1H19_RS35175	COG1946	Acyl-CoA thioesterase
B1H19_RS35200	COG1132	(ABC) transporter
B1H19_RS35205	COG1132	(ABC) transporter
B1H19_RS35235	COG1132	(ABC) transporter
B1H19_RS35260	COG1556	Lactate utilization protein
B1H19_RS35265	COG1139	Iron-sulfur cluster binding protein
B1H19_RS35270	COG0247	lactate metabolic process
B1H19_RS35275	COG0477	Major facilitator Superfamily
B1H19_RS35290	COG2018	Roadblock/LC7 domain
B1H19_RS35315	COG0432	Pfam Uncharacterised protein family UPF0047
B1H19_RS35350	COG1309	transcriptional regulator
B1H19_RS35370	COG0523	cobalamin synthesis protein
B1H19_RS35430	COG3896	Chloramphenicol phosphotransferase-like protein
B1H19_RS35455	COG1090	epimerase
B1H19_RS35480	COG1595	DNA-templated transcription, initiation
B1H19_RS35490	COG1078	dGTPase activity
B1H19_RS35530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1H19_RS35530	COG1796	DNA polymerase
B1H19_RS35535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1H19_RS35545	COG0346	lactoylglutathione lyase activity
B1H19_RS35565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1H19_RS35600	COG2175	clavaminate synthase activity
B1H19_RS35605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1H19_RS35655	COG0531	amino acid
B1H19_RS35670	COG0300	oxidoreductase activity
B1H19_RS35685	COG4221	oxidoreductase activity
B1H19_RS35700	COG1309	transcriptional regulator
B1H19_RS35710	COG0596	Alpha beta hydrolase
B1H19_RS35715	COG1309	transcriptional regulator
B1H19_RS35740	COG2080	2 iron, 2 sulfur cluster binding
B1H19_RS35745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1H19_RS35750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1H19_RS35775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1H19_RS35785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1H19_RS35795	COG4213	ABC transporter substrate-binding protein
B1H19_RS35800	COG4221	oxidoreductase activity
B1H19_RS35805	COG3227	Zinc metalloprotease (Elastase)
B1H19_RS35860	COG2706	6-phosphogluconolactonase activity
B1H19_RS35885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1H19_RS35895	COG1902	pentaerythritol trinitrate reductase activity
B1H19_RS35915	COG1309	transcriptional regulator
B1H19_RS35990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1H19_RS36000	COG1335	isochorismatase
B1H19_RS36005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B1H19_RS36040	COG0592	DNA-directed DNA polymerase activity
B1H19_RS36085	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS36095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1H19_RS36155	COG1012	belongs to the aldehyde dehydrogenase family
B1H19_RS36175	COG1309	transcriptional regulator
B1H19_RS36190	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS36205	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS36235	COG1228	amidohydrolase
B1H19_RS36245	COG0463	Glycosyl transferase, family 2
B1H19_RS36260	COG2270	Major facilitator Superfamily
B1H19_RS36290	COG3012	SEC-C Motif Domain Protein
B1H19_RS36300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B1H19_RS36305	COG3285	dna ligase
B1H19_RS36305	COG1793	dna ligase
B1H19_RS36315	COG1278	Cold shock
B1H19_RS36345	COG0395	ABC-type sugar transport system, permease component
B1H19_RS36350	COG1175	transmembrane transport
B1H19_RS36355	COG1653	transport
B1H19_RS36405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1H19_RS36415	COG1846	Transcriptional regulator
B1H19_RS36420	COG1764	response to oxidative stress
B1H19_RS36465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1H19_RS36530	COG1832	CoA-binding protein
B1H19_RS36540	COG1739	Uncharacterized protein family UPF0029
B1H19_RS36545	COG0531	amino acid
B1H19_RS36585	COG0420	3'-5' exonuclease activity
B1H19_RS36590	COG0419	ATPase involved in DNA repair
B1H19_RS36610	COG2188	Transcriptional regulator
B1H19_RS36615	COG1940	carbohydrate kinase activity
B1H19_RS36625	COG3663	DNA glycosylase
B1H19_RS36630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1H19_RS36680	COG1309	transcriptional regulator
B1H19_RS36700	COG0456	acetyltransferase
B1H19_RS36720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B1H19_RS36725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1H19_RS36730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1H19_RS36745	COG0583	DNA-binding transcription factor activity
B1H19_RS36750	COG1280	lysine exporter protein (LysE YggA)
B1H19_RS36765	COG0740	serine-type endopeptidase activity
B1H19_RS36780	COG0831	urea catabolic process
B1H19_RS36785	COG0832	Belongs to the urease beta subunit family
B1H19_RS36790	COG0804	urea catabolic process
B1H19_RS36795	COG0830	nickel cation binding
B1H19_RS36800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1H19_RS36805	COG0829	nickel cation binding
B1H19_RS36835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1H19_RS36860	COG0205	6-phosphofructokinase activity
B1H19_RS36865	COG3442	glutamine amidotransferase
B1H19_RS36875	COG0242	peptide deformylase activity
B1H19_RS36885	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS36890	COG4181	ATPase activity
B1H19_RS36900	COG0456	acetyltransferase
B1H19_RS36915	COG3960	tartronate-semialdehyde synthase activity
B1H19_RS36920	COG3622	Belongs to the hyi family
B1H19_RS36925	COG2084	Dehydrogenase
B1H19_RS36955	COG1802	Transcriptional regulator
B1H19_RS36960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1H19_RS36975	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B1H19_RS37000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B1H19_RS37005	COG0375	protein maturation
B1H19_RS37010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1H19_RS37015	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B1H19_RS37020	COG0298	carbon dioxide binding
B1H19_RS37030	COG0309	Hydrogenase expression formation protein (HypE)
B1H19_RS37055	COG0531	amino acid
B1H19_RS37070	COG1793	dna ligase
B1H19_RS37090	COG0318	PFAM AMP-dependent synthetase and ligase
B1H19_RS37125	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS37130	COG1960	acyl-CoA dehydrogenase activity
B1H19_RS37135	COG1024	Enoyl-CoA hydratase
B1H19_RS37140	COG1028	Short-chain dehydrogenase reductase Sdr
B1H19_RS37145	COG0183	Belongs to the thiolase family
B1H19_RS37155	COG2814	Major facilitator Superfamily
B1H19_RS37175	COG1024	Enoyl-CoA hydratase
B1H19_RS37280	COG3387	PFAM Glycoside hydrolase 15-related
B1H19_RS37295	COG0010	Belongs to the arginase family
B1H19_RS37400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1H19_RS37425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1H19_RS37445	COG2207	Transcriptional regulator
B1H19_RS37450	COG2223	nitrite transmembrane transporter activity
B1H19_RS37475	COG0529	Catalyzes the synthesis of activated sulfate
B1H19_RS37510	COG0702	epimerase
B1H19_RS37545	COG3547	Transposase (IS116 IS110 IS902 family)