locus-tag	class	description
WQO_RS00030	COG0305	Participates in initiation and elongation during chromosome replication
WQO_RS00090	COG3328	transposase activity
WQO_RS00115	COG2239	Acts as a magnesium transporter
WQO_RS00130	COG0516	GMP reductase activity
WQO_RS00130	COG0517	IMP dehydrogenase activity
WQO_RS00135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WQO_RS00140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WQO_RS00145	COG0508	dehydrogenase complex catalyzes the overall conversion of
WQO_RS00145	COG0022	dehydrogenase e1 component
WQO_RS00150	COG0508	dehydrogenase complex catalyzes the overall conversion of
WQO_RS00160	COG0517	IMP dehydrogenase activity
WQO_RS00165	COG3383	formate dehydrogenase (NAD+) activity
WQO_RS00170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WQO_RS00185	COG2376	Dihydroxyacetone kinase
WQO_RS00190	COG2376	Dihydroxyacetone kinase
WQO_RS00265	COG2770	Histidine kinase
WQO_RS00265	COG2208	phosphoserine phosphatase activity
WQO_RS00275	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
WQO_RS00285	COG0587	DNA-directed DNA polymerase activity
WQO_RS00290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WQO_RS00325	COG0515	serine threonine protein kinase
WQO_RS00325	COG2815	serine threonine protein kinase
WQO_RS00370	COG2382	esterase
WQO_RS00370	COG3693	PFAM glycoside hydrolase, family 10
WQO_RS00370	COG3507	Belongs to the glycosyl hydrolase 43 family
WQO_RS00435	COG4251	negative regulation of phosphorylation
WQO_RS00440	COG0784	Response regulator, receiver
WQO_RS00485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WQO_RS00505	COG3293	Transposase
WQO_RS00530	COG3293	Transposase
WQO_RS00585	COG3795	YCII-related domain
WQO_RS00590	COG4941	Belongs to the sigma-70 factor family
WQO_RS00605	COG5297	Belongs to the glycosyl hydrolase family 6
WQO_RS00635	COG0477	Major facilitator Superfamily
WQO_RS00645	COG1846	Transcriptional regulator
WQO_RS00650	COG1764	response to oxidative stress
WQO_RS00705	COG0277	FAD linked oxidase domain protein
WQO_RS00715	COG1064	alcohol dehydrogenase
WQO_RS00725	COG2226	methyltransferase
WQO_RS00735	COG0702	epimerase
WQO_RS00765	COG0583	DNA-binding transcription factor activity
WQO_RS00780	COG0642	Histidine kinase
WQO_RS00795	COG2318	DinB family
WQO_RS00805	COG0366	Alpha amylase catalytic
WQO_RS00810	COG0395	ABC-type sugar transport system, permease component
WQO_RS00815	COG1175	transmembrane transport
WQO_RS00820	COG1653	transport
WQO_RS00855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WQO_RS00860	COG0596	Alpha beta hydrolase
WQO_RS00875	COG1349	DNA-binding transcription factor activity
WQO_RS00880	COG1105	Belongs to the carbohydrate kinase PfkB family
WQO_RS00890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WQO_RS00900	COG0681	Belongs to the peptidase S26 family
WQO_RS00945	COG2318	DinB family
WQO_RS00975	COG0254	rRNA binding
WQO_RS00980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WQO_RS01010	COG1309	transcriptional regulator
WQO_RS01040	COG1024	Enoyl-CoA hydratase
WQO_RS01080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS01085	COG0765	amino acid transport
WQO_RS01105	COG2366	antibiotic biosynthetic process
WQO_RS01115	COG2070	2-Nitropropane dioxygenase
WQO_RS01120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WQO_RS01135	COG0515	serine threonine protein kinase
WQO_RS01155	COG1960	acyl-CoA dehydrogenase activity
WQO_RS01160	COG2813	Specifically methylates the guanine in position
WQO_RS01175	COG2356	endonuclease I
WQO_RS01180	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
WQO_RS01180	COG2066	Belongs to the glutaminase family
WQO_RS01200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WQO_RS01205	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS01215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WQO_RS01220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WQO_RS01225	COG2080	2 iron, 2 sulfur cluster binding
WQO_RS01280	COG2365	Tyrosine phosphatase family
WQO_RS01305	COG1120	ATPase activity
WQO_RS01310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WQO_RS01320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS01330	COG0477	Major facilitator Superfamily
WQO_RS01335	COG2382	esterase
WQO_RS01340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS01350	COG1169	isochorismate synthase
WQO_RS01355	COG1021	2,3-dihydroxybenzoate-AMP ligase
WQO_RS01360	COG3433	isochorismatase activity
WQO_RS01360	COG1535	isochorismatase
WQO_RS01365	COG1535	isochorismatase
WQO_RS01365	COG3433	isochorismatase activity
WQO_RS01390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WQO_RS01425	COG3845	ABC transporter
WQO_RS01435	COG1470	cell adhesion involved in biofilm formation
WQO_RS01450	COG0148	phosphopyruvate hydratase activity
WQO_RS01460	COG2382	esterase
WQO_RS01465	COG1132	(ABC) transporter
WQO_RS01475	COG1132	(ABC) transporter
WQO_RS01480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
WQO_RS01485	COG1120	ATPase activity
WQO_RS01490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS01500	COG3486	L-lysine 6-monooxygenase (NADPH) activity
WQO_RS01515	COG5002	protein histidine kinase activity
WQO_RS01520	COG0745	RESPONSE REGULATOR receiver
WQO_RS01550	COG3559	Exporter of polyketide antibiotics
WQO_RS01555	COG1131	(ABC) transporter
WQO_RS01570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WQO_RS01575	COG0587	DNA-directed DNA polymerase activity
WQO_RS01580	COG1302	Protein conserved in bacteria
WQO_RS01585	COG0142	geranyltranstransferase activity
WQO_RS01605	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
WQO_RS01610	COG2226	methyltransferase
WQO_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS01625	COG2318	DinB family
WQO_RS01640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WQO_RS01660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WQO_RS01660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WQO_RS01715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS01745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WQO_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS01780	COG0300	oxidoreductase activity
WQO_RS01785	COG2376	Dihydroxyacetone kinase
WQO_RS01790	COG1461	Dihydroxyacetone kinase
WQO_RS01805	COG0488	(ABC) transporter
WQO_RS01835	COG1191	sigma factor activity
WQO_RS01840	COG1309	transcriptional regulator
WQO_RS01845	COG3246	L-lysine catabolic process to acetate
WQO_RS01850	COG1250	3-hydroxyacyl-CoA dehydrogenase
WQO_RS01865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WQO_RS01885	COG1120	ATPase activity
WQO_RS01890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS01915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS01960	COG1959	2 iron, 2 sulfur cluster binding
WQO_RS01960	COG1295	ribonuclease BN
WQO_RS01995	COG2837	iron assimilation
WQO_RS02005	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS02045	COG1609	Transcriptional regulator
WQO_RS02050	COG1172	Belongs to the binding-protein-dependent transport system permease family
WQO_RS02060	COG1129	ABC transporter
WQO_RS02065	COG1879	ABC-type sugar transport system periplasmic component
WQO_RS02125	COG0328	RNA-DNA hybrid ribonuclease activity
WQO_RS02135	COG1132	(ABC) transporter
WQO_RS02145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
WQO_RS02160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS02235	COG0395	ABC-type sugar transport system, permease component
WQO_RS02295	COG1215	transferase activity, transferring glycosyl groups
WQO_RS02315	COG0464	growth
WQO_RS02325	COG1349	DNA-binding transcription factor activity
WQO_RS02340	COG0702	epimerase
WQO_RS02370	COG1940	carbohydrate kinase activity
WQO_RS02375	COG2223	nitrite transmembrane transporter activity
WQO_RS02385	COG2197	response regulator
WQO_RS02390	COG4585	Histidine kinase
WQO_RS02405	COG0445	tRNA wobble uridine modification
WQO_RS02420	COG1660	Displays ATPase and GTPase activities
WQO_RS02430	COG1940	carbohydrate kinase activity
WQO_RS02460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WQO_RS02505	COG0584	glycerophosphoryl diester phosphodiesterase
WQO_RS02525	COG0671	phosphoesterase, PA-phosphatase related
WQO_RS02570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WQO_RS02585	COG2706	6-phosphogluconolactonase activity
WQO_RS02605	COG2815	serine threonine protein kinase
WQO_RS02605	COG0515	serine threonine protein kinase
WQO_RS02610	COG0667	Aldo Keto reductase
WQO_RS02645	COG1253	flavin adenine dinucleotide binding
WQO_RS02680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WQO_RS02685	COG0531	amino acid
WQO_RS02695	COG0174	glutamine synthetase
WQO_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS02730	COG4981	capsule polysaccharide biosynthetic process
WQO_RS02750	COG2835	tetraacyldisaccharide 4'-kinase activity
WQO_RS02760	COG1802	Transcriptional regulator
WQO_RS02765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WQO_RS02770	COG0402	S-adenosylhomocysteine deaminase activity
WQO_RS02775	COG0745	RESPONSE REGULATOR receiver
WQO_RS02810	COG0542	response to heat
WQO_RS02865	COG1191	sigma factor activity
WQO_RS02880	COG2890	protein-(glutamine-N5) methyltransferase activity
WQO_RS02900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WQO_RS02905	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WQO_RS02910	COG2080	2 iron, 2 sulfur cluster binding
WQO_RS02925	COG2986	histidine ammonia-lyase
WQO_RS02935	COG1174	glycine betaine transport
WQO_RS02950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WQO_RS02970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WQO_RS03010	COG4214	carbohydrate transport
WQO_RS03025	COG1609	Transcriptional regulator
WQO_RS03035	COG2160	L-arabinose isomerase activity
WQO_RS03045	COG1891	lyase activity
WQO_RS03050	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS03060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
WQO_RS03085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WQO_RS03105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WQO_RS03110	COG0385	Bile acid
WQO_RS03130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WQO_RS03185	COG2197	response regulator
WQO_RS03195	COG0640	Transcriptional regulator
WQO_RS03200	COG2801	Transposase and inactivated derivatives
WQO_RS03235	COG3293	Transposase
WQO_RS03245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WQO_RS03255	COG0798	PFAM Bile acid sodium symporter
WQO_RS03260	COG1247	-acetyltransferase
WQO_RS03265	COG0640	Transcriptional regulator
WQO_RS03290	COG3335	DDE superfamily endonuclease
WQO_RS03310	COG4585	Histidine kinase
WQO_RS03315	COG2197	response regulator
WQO_RS03330	COG1132	(ABC) transporter
WQO_RS03420	COG0531	amino acid
WQO_RS03430	COG0745	RESPONSE REGULATOR receiver
WQO_RS03455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WQO_RS03460	COG0516	GMP reductase activity
WQO_RS03460	COG0517	IMP dehydrogenase activity
WQO_RS03470	COG0640	Transcriptional regulator
WQO_RS03485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WQO_RS03495	COG4109	DRTGG domain
WQO_RS03515	COG1063	alcohol dehydrogenase
WQO_RS03520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WQO_RS03525	COG0517	IMP dehydrogenase activity
WQO_RS03525	COG1227	inorganic diphosphatase activity
WQO_RS03535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WQO_RS03545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WQO_RS03545	COG0574	Belongs to the PEP-utilizing enzyme family
WQO_RS03575	COG1937	Protein conserved in bacteria
WQO_RS03580	COG0730	response to heat
WQO_RS03590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WQO_RS03590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WQO_RS03625	COG0142	geranyltranstransferase activity
WQO_RS03645	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
WQO_RS03665	COG1191	sigma factor activity
WQO_RS03710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WQO_RS03730	COG0601	transmembrane transport
WQO_RS03735	COG0747	negative chemotaxis
WQO_RS03740	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WQO_RS03745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS03755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS03780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WQO_RS03785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WQO_RS03845	COG3293	Transposase
WQO_RS03890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
WQO_RS03895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WQO_RS03900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WQO_RS03915	COG0531	amino acid
WQO_RS03920	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WQO_RS03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WQO_RS03935	COG1116	anion transmembrane transporter activity
WQO_RS03945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS03955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WQO_RS03965	COG1132	(ABC) transporter
WQO_RS03970	COG1846	Transcriptional regulator
WQO_RS03975	COG0277	FAD linked oxidase domain protein
WQO_RS03985	COG1132	(ABC) transporter
WQO_RS03990	COG1132	(ABC) transporter
WQO_RS04010	COG1793	dna ligase
WQO_RS04025	COG1946	Acyl-CoA thioesterase
WQO_RS04055	COG0386	Belongs to the glutathione peroxidase family
WQO_RS04060	COG1960	acyl-CoA dehydrogenase activity
WQO_RS04070	COG0242	peptide deformylase activity
WQO_RS04080	COG3442	glutamine amidotransferase
WQO_RS04085	COG0205	6-phosphofructokinase activity
WQO_RS04095	COG0204	Acyl-transferase
WQO_RS04110	COG0829	nickel cation binding
WQO_RS04115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WQO_RS04125	COG0804	urea catabolic process
WQO_RS04130	COG0832	Belongs to the urease beta subunit family
WQO_RS04135	COG0831	urea catabolic process
WQO_RS04155	COG0740	serine-type endopeptidase activity
WQO_RS04170	COG1280	lysine exporter protein (LysE YggA)
WQO_RS04175	COG0583	DNA-binding transcription factor activity
WQO_RS04190	COG0156	8-amino-7-oxononanoate synthase activity
WQO_RS04195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WQO_RS04200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WQO_RS04205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WQO_RS04210	COG2226	methyltransferase
WQO_RS04245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WQO_RS04255	COG1940	carbohydrate kinase activity
WQO_RS04260	COG2188	Transcriptional regulator
WQO_RS04265	COG1595	DNA-templated transcription, initiation
WQO_RS04280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS04305	COG0626	cystathionine gamma-synthase activity
WQO_RS04330	COG1522	sequence-specific DNA binding
WQO_RS04335	COG0419	ATPase involved in DNA repair
WQO_RS04340	COG0420	3'-5' exonuclease activity
WQO_RS04345	COG1739	Uncharacterized protein family UPF0029
WQO_RS04350	COG1832	CoA-binding protein
WQO_RS04395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WQO_RS04410	COG1968	undecaprenyl-diphosphatase activity
WQO_RS04420	COG0243	molybdopterin cofactor binding
WQO_RS04425	COG2226	methyltransferase
WQO_RS04430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WQO_RS04470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WQO_RS04490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WQO_RS04530	COG0583	DNA-binding transcription factor activity
WQO_RS04565	COG0583	DNA-binding transcription factor activity
WQO_RS04570	COG0697	spore germination
WQO_RS04610	COG1695	Transcriptional regulator
WQO_RS04660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WQO_RS04660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WQO_RS04670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WQO_RS04690	COG1716	ATPase activity
WQO_RS04710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WQO_RS04740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WQO_RS04750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WQO_RS04765	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
WQO_RS04795	COG2018	Roadblock/LC7 domain
WQO_RS04865	COG2364	Membrane
WQO_RS04875	COG2270	Major facilitator Superfamily
WQO_RS04890	COG1216	Glycosyl transferase, family 2
WQO_RS04910	COG1960	acyl-CoA dehydrogenase activity
WQO_RS04920	COG2318	DinB family
WQO_RS04975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WQO_RS04980	COG0140	phosphoribosyl-ATP diphosphatase activity
WQO_RS04985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WQO_RS04990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WQO_RS04990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WQO_RS04995	COG3201	nicotinamide mononucleotide transporter
WQO_RS05015	COG0702	epimerase
WQO_RS05020	COG1940	carbohydrate kinase activity
WQO_RS05025	COG0738	Major facilitator superfamily
WQO_RS05030	COG2233	PERMEase
WQO_RS05050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WQO_RS05060	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS05075	COG2390	Transcriptional regulator
WQO_RS05080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WQO_RS05090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WQO_RS05100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WQO_RS05105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WQO_RS05115	COG1758	RNA polymerase activity
WQO_RS05130	COG0284	orotidine-5'-phosphate decarboxylase activity
WQO_RS05135	COG0167	dihydroorotate dehydrogenase activity
WQO_RS05140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WQO_RS05145	COG0505	Belongs to the CarA family
WQO_RS05155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WQO_RS05160	COG0540	Belongs to the ATCase OTCase family
WQO_RS05165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
WQO_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WQO_RS05180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WQO_RS05185	COG0006	proline dipeptidase activity
WQO_RS05195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WQO_RS05200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WQO_RS05205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WQO_RS05210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WQO_RS05220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WQO_RS05225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WQO_RS05245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WQO_RS05265	COG0124	histidyl-tRNA synthetase
WQO_RS05280	COG1196	nuclear chromosome segregation
WQO_RS05285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WQO_RS05295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WQO_RS05300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WQO_RS05305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WQO_RS05315	COG2255	four-way junction helicase activity
WQO_RS05320	COG0632	four-way junction helicase activity
WQO_RS05325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WQO_RS05330	COG0217	transcriptional regulatory protein
WQO_RS05335	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
WQO_RS05340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
WQO_RS05350	COG0438	transferase activity, transferring glycosyl groups
WQO_RS05355	COG1560	Kdo2-lipid A biosynthetic process
WQO_RS05360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WQO_RS05385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WQO_RS05400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WQO_RS05445	COG0456	acetyltransferase
WQO_RS05445	COG0454	-acetyltransferase
WQO_RS05455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WQO_RS05510	COG1648	precorrin-2 dehydrogenase activity
WQO_RS05510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WQO_RS05515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
WQO_RS05530	COG1464	Belongs to the NlpA lipoprotein family
WQO_RS05535	COG2011	ABC-type metal ion transport system permease component
WQO_RS05575	COG0477	Major facilitator Superfamily
WQO_RS05585	COG3973	AAA domain
WQO_RS05595	COG0165	Argininosuccinate lyase
WQO_RS05600	COG0137	argininosuccinate synthase activity
WQO_RS05610	COG1438	arginine binding
WQO_RS05615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WQO_RS05620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WQO_RS05625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WQO_RS05630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WQO_RS05680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WQO_RS05695	COG0697	spore germination
WQO_RS05705	COG1649	PFAM Uncharacterised BCR, COG1649
WQO_RS05730	COG0072	phenylalanine-tRNA ligase activity
WQO_RS05730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WQO_RS05735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WQO_RS05740	COG5002	protein histidine kinase activity
WQO_RS05745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WQO_RS05750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WQO_RS05755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WQO_RS05760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WQO_RS05770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WQO_RS05780	COG1404	Belongs to the peptidase S8 family
WQO_RS05830	COG4175	Glycine betaine
WQO_RS05830	COG0517	IMP dehydrogenase activity
WQO_RS05835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WQO_RS05880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WQO_RS05885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WQO_RS05920	COG0805	protein transport
WQO_RS05925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WQO_RS05945	COG2378	regulation of single-species biofilm formation
WQO_RS05955	COG0545	Peptidyl-prolyl cis-trans isomerase
WQO_RS05960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
WQO_RS05970	COG1609	Transcriptional regulator
WQO_RS05975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
WQO_RS05980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
WQO_RS05990	COG4122	O-methyltransferase activity
WQO_RS05995	COG1222	aaa ATPase
WQO_RS06015	COG0517	IMP dehydrogenase activity
WQO_RS06015	COG1994	Peptidase M50
WQO_RS06025	COG2197	response regulator
WQO_RS06030	COG4166	transmembrane transport
WQO_RS06040	COG1410	methionine synthase
WQO_RS06040	COG0646	methionine synthase
WQO_RS06045	COG1414	Transcriptional regulator
WQO_RS06050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WQO_RS06055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WQO_RS06060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WQO_RS06065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS06080	COG0215	cysteine-tRNA ligase activity
WQO_RS06100	COG0598	Magnesium transport protein CorA
WQO_RS06110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS06115	COG0667	Aldo Keto reductase
WQO_RS06145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WQO_RS06155	COG0564	pseudouridine synthase activity
WQO_RS06170	COG2186	Transcriptional regulator
WQO_RS06175	COG3265	gluconokinase activity
WQO_RS06200	COG3573	Dehydrogenase
WQO_RS06205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WQO_RS06210	COG2149	membrane
WQO_RS06225	COG4948	Mandelate Racemase Muconate Lactonizing
WQO_RS06235	COG1960	acyl-CoA dehydrogenase activity
WQO_RS06240	COG4935	Belongs to the peptidase S8 family
WQO_RS06240	COG2234	aminopeptidase activity
WQO_RS06250	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS06260	COG3876	Protein conserved in bacteria
WQO_RS06275	COG0789	Transcriptional regulator
WQO_RS06295	COG1960	acyl-CoA dehydrogenase activity
WQO_RS06305	COG0640	Transcriptional regulator
WQO_RS06315	COG2326	polyphosphate kinase activity
WQO_RS06330	COG2318	DinB family
WQO_RS06340	COG2851	Citrate transporter
WQO_RS06345	COG0243	molybdopterin cofactor binding
WQO_RS06350	COG1309	transcriptional regulator
WQO_RS06355	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WQO_RS06360	COG2188	Transcriptional regulator
WQO_RS06370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WQO_RS06380	COG2755	lipolytic protein G-D-S-L family
WQO_RS06390	COG1725	Transcriptional regulator
WQO_RS06405	COG2226	methyltransferase
WQO_RS06425	COG4565	transcriptional regulatory protein
WQO_RS06470	COG0641	radical SAM
WQO_RS06495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS06500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS06505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS06525	COG0765	amino acid transport
WQO_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS06540	COG1799	cell septum assembly
WQO_RS06545	COG1960	acyl-CoA dehydrogenase activity
WQO_RS06550	COG0477	Major facilitator Superfamily
WQO_RS06555	COG0671	phosphoesterase, PA-phosphatase related
WQO_RS06575	COG0438	transferase activity, transferring glycosyl groups
WQO_RS06590	COG1160	GTP binding
WQO_RS06600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WQO_RS06660	COG1187	pseudouridine synthase activity
WQO_RS06665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WQO_RS06670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WQO_RS06685	COG0686	Belongs to the AlaDH PNT family
WQO_RS06695	COG0494	nUDIX hydrolase
WQO_RS06700	COG0504	CTP synthase activity
WQO_RS06705	COG3387	PFAM Glycoside hydrolase 15-related
WQO_RS06715	COG0789	Transcriptional regulator
WQO_RS06730	COG0497	DNA recombination
WQO_RS06735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WQO_RS06755	COG1120	ATPase activity
WQO_RS06760	COG0647	UMP catabolic process
WQO_RS06795	COG2094	Belongs to the DNA glycosylase MPG family
WQO_RS06805	COG1881	PFAM PEBP family protein
WQO_RS06830	COG1119	ATPase activity
WQO_RS06845	COG2197	response regulator
WQO_RS06860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WQO_RS06870	COG1716	ATPase activity
WQO_RS06870	COG1131	(ABC) transporter
WQO_RS06870	COG0842	Transport permease protein
WQO_RS06875	COG0560	Phosphoserine phosphatase
WQO_RS06875	COG3830	Belongs to the UPF0237 family
WQO_RS06895	COG2186	Transcriptional regulator
WQO_RS06905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WQO_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS06925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WQO_RS06930	COG2261	transglycosylase associated protein
WQO_RS06945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WQO_RS06950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WQO_RS06980	COG1199	ATP-dependent helicase activity
WQO_RS06980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WQO_RS06995	COG3387	PFAM Glycoside hydrolase 15-related
WQO_RS07045	COG0488	(ABC) transporter
WQO_RS07070	COG0235	Class ii aldolase
WQO_RS07085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
WQO_RS07090	COG1492	cobalamin metabolic process
WQO_RS07105	COG1797	cobyrinic acid a,c-diamide synthase activity
WQO_RS07130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WQO_RS07160	COG1902	pentaerythritol trinitrate reductase activity
WQO_RS07165	COG1846	Transcriptional regulator
WQO_RS07195	COG1414	Transcriptional regulator
WQO_RS07200	COG2197	response regulator
WQO_RS07205	COG0768	penicillin binding
WQO_RS07215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS07225	COG0431	NADPH-dependent FMN reductase
WQO_RS07240	COG0583	DNA-binding transcription factor activity
WQO_RS07255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WQO_RS07260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WQO_RS07290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WQO_RS07300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WQO_RS07305	COG2171	N-acyltransferase activity
WQO_RS07320	COG3226	Transcriptional regulator
WQO_RS07335	COG2151	metal-sulfur cluster biosynthetic enzyme
WQO_RS07340	COG0822	iron-sulfur transferase activity
WQO_RS07345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WQO_RS07350	COG0396	ATPase activity
WQO_RS07360	COG0719	Fe-S assembly protein
WQO_RS07400	COG0109	protoheme IX farnesyltransferase activity
WQO_RS07410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WQO_RS07425	COG0363	glucosamine-6-phosphate deaminase activity
WQO_RS07445	COG0166	Belongs to the GPI family
WQO_RS07455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WQO_RS07460	COG0149	triose-phosphate isomerase activity
WQO_RS07465	COG0126	phosphoglycerate kinase activity
WQO_RS07470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WQO_RS07475	COG1481	regulation of sporulation
WQO_RS07480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WQO_RS07485	COG1660	Displays ATPase and GTPase activities
WQO_RS07490	COG0322	excinuclease ABC activity
WQO_RS07515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WQO_RS07545	COG0556	nucleotide-excision repair
WQO_RS07555	COG0584	glycerophosphoryl diester phosphodiesterase
WQO_RS07560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WQO_RS07565	COG2814	Major facilitator Superfamily
WQO_RS07575	COG2313	pseudouridylate synthase activity
WQO_RS07595	COG0436	Aminotransferase
WQO_RS07615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WQO_RS07625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WQO_RS07640	COG0237	dephospho-CoA kinase activity
WQO_RS07660	COG2226	methyltransferase
WQO_RS07665	COG1643	Atp-dependent helicase
WQO_RS07690	COG2050	protein possibly involved in aromatic compounds catabolism
WQO_RS07745	COG0737	Belongs to the 5'-nucleotidase family
WQO_RS07750	COG3415	Transposase
WQO_RS07750	COG2801	Transposase and inactivated derivatives
WQO_RS07780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WQO_RS07785	COG1605	Chorismate mutase
WQO_RS07785	COG0287	Prephenate dehydrogenase
WQO_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS07830	COG1024	Enoyl-CoA hydratase
WQO_RS07855	COG1278	Cold shock
WQO_RS07860	COG0183	Belongs to the thiolase family
WQO_RS07865	COG1309	transcriptional regulator
WQO_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS07875	COG1960	acyl-CoA dehydrogenase activity
WQO_RS07880	COG1960	acyl-CoA dehydrogenase activity
WQO_RS07900	COG0705	Rhomboid family
WQO_RS07910	COG0069	glutamate synthase activity
WQO_RS07910	COG0067	glutamate synthase
WQO_RS07910	COG0070	glutamate synthase
WQO_RS07940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WQO_RS07945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WQO_RS07955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WQO_RS07965	COG0159	tryptophan synthase activity
WQO_RS07970	COG0133	tryptophan synthase activity
WQO_RS07975	COG0134	indole-3-glycerol-phosphate synthase activity
WQO_RS07995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WQO_RS08000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WQO_RS08020	COG2508	Transcriptional regulator
WQO_RS08025	COG0107	imidazoleglycerol-phosphate synthase activity
WQO_RS08030	COG0251	oxidation-reduction process
WQO_RS08035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WQO_RS08040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WQO_RS08050	COG0131	Imidazoleglycerol-phosphate dehydratase
WQO_RS08055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WQO_RS08060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WQO_RS08100	COG1432	Conserved Protein
WQO_RS08110	COG0587	DNA-directed DNA polymerase activity
WQO_RS08155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WQO_RS08165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WQO_RS08170	COG3599	regulation of cell shape
WQO_RS08180	COG1799	cell septum assembly
WQO_RS08185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WQO_RS08205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WQO_RS08215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WQO_RS08220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WQO_RS08230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WQO_RS08235	COG0768	penicillin binding
WQO_RS08245	COG0275	rRNA processing
WQO_RS08255	COG0714	Associated with various cellular activities
WQO_RS08275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WQO_RS08285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WQO_RS08305	COG1233	COG1233 Phytoene dehydrogenase and related
WQO_RS08320	COG0352	thiamine-phosphate diphosphorylase activity
WQO_RS08340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WQO_RS08340	COG2022	thiamine diphosphate biosynthetic process
WQO_RS08350	COG2022	thiamine diphosphate biosynthetic process
WQO_RS08355	COG0515	serine threonine protein kinase
WQO_RS08355	COG2815	serine threonine protein kinase
WQO_RS08360	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WQO_RS08365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WQO_RS08370	COG2193	ferroxidase activity
WQO_RS08380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WQO_RS08390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WQO_RS08395	COG2197	response regulator
WQO_RS08425	COG1940	carbohydrate kinase activity
WQO_RS08435	COG0003	Pfam Anion-transporting ATPase
WQO_RS08500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WQO_RS08505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WQO_RS08510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WQO_RS08515	COG0723	plastoquinol--plastocyanin reductase activity
WQO_RS08520	COG2010	Cytochrome c
WQO_RS08525	COG1845	cytochrome c oxidase, subunit III
WQO_RS08535	COG1376	ErfK ybiS ycfS ynhG family protein
WQO_RS08545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WQO_RS08550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WQO_RS08560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WQO_RS08580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WQO_RS08590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WQO_RS08595	COG2197	response regulator
WQO_RS08600	COG4585	Histidine kinase
WQO_RS08620	COG2226	methyltransferase
WQO_RS08625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WQO_RS08640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
WQO_RS08655	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
WQO_RS08660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WQO_RS08665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WQO_RS08670	COG0508	dehydrogenase complex catalyzes the overall conversion of
WQO_RS08680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WQO_RS08700	COG1090	epimerase
WQO_RS08720	COG0321	lipoyl(octanoyl) transferase activity
WQO_RS08725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WQO_RS08760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WQO_RS08765	COG3896	Chloramphenicol phosphotransferase-like protein
WQO_RS08790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WQO_RS08795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS08820	COG0745	RESPONSE REGULATOR receiver
WQO_RS08825	COG2409	Drug exporters of the RND superfamily
WQO_RS08835	COG2197	response regulator
WQO_RS08905	COG0366	Alpha amylase catalytic
WQO_RS08910	COG0395	ABC-type sugar transport system, permease component
WQO_RS08920	COG2182	Extracellular solute-binding protein
WQO_RS08925	COG1609	Transcriptional regulator
WQO_RS08950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WQO_RS08960	COG2890	protein-(glutamine-N5) methyltransferase activity
WQO_RS08965	COG2814	Major facilitator Superfamily
WQO_RS08995	COG0174	glutamine synthetase
WQO_RS09020	COG2132	Multicopper oxidase
WQO_RS09025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WQO_RS09025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WQO_RS09030	COG2814	Major facilitator Superfamily
WQO_RS09045	COG0477	Major facilitator Superfamily
WQO_RS09050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WQO_RS09070	COG1994	Peptidase M50
WQO_RS09110	COG5398	heme oxygenase
WQO_RS09135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS09140	COG1120	ATPase activity
WQO_RS09160	COG1834	amidinotransferase
WQO_RS09175	COG2814	Major facilitator Superfamily
WQO_RS09185	COG3540	Alkaline phosphatase
WQO_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS09200	COG0384	phenazine biosynthesis protein PhzF
WQO_RS09235	COG2273	Hydrolase Family 16
WQO_RS09260	COG3022	response to hydroperoxide
WQO_RS09265	COG0800	Aldolase
WQO_RS09285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WQO_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS09305	COG2030	dehydratase
WQO_RS09315	COG0183	Belongs to the thiolase family
WQO_RS09320	COG1960	acyl-CoA dehydrogenase activity
WQO_RS09345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS09380	COG0438	transferase activity, transferring glycosyl groups
WQO_RS09385	COG1309	transcriptional regulator
WQO_RS09485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WQO_RS09505	COG3845	ABC transporter
WQO_RS09515	COG0183	Belongs to the thiolase family
WQO_RS09520	COG2124	cytochrome p450
WQO_RS09570	COG2259	Doxx family
WQO_RS09645	COG1358	cellular component organization or biogenesis
WQO_RS09690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WQO_RS09700	COG0477	Major facilitator Superfamily
WQO_RS09705	COG1309	transcriptional regulator
WQO_RS09720	COG4585	Histidine kinase
WQO_RS09725	COG2197	response regulator
WQO_RS09740	COG0667	Aldo Keto reductase
WQO_RS09745	COG0789	Transcriptional regulator
WQO_RS09755	COG2205	protein histidine kinase activity
WQO_RS09760	COG0745	RESPONSE REGULATOR receiver
WQO_RS09770	COG1929	Belongs to the glycerate kinase type-1 family
WQO_RS09790	COG1131	(ABC) transporter
WQO_RS09810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS09885	COG1674	ftsk spoiiie
WQO_RS09890	COG1404	Belongs to the peptidase S8 family
WQO_RS09910	COG1741	Belongs to the pirin family
WQO_RS09925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WQO_RS09930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WQO_RS09935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS09955	COG1280	lysine exporter protein (LysE YggA)
WQO_RS09965	COG1764	response to oxidative stress
WQO_RS09970	COG2130	NADP-dependent
WQO_RS10000	COG1522	sequence-specific DNA binding
WQO_RS10015	COG3291	Pkd domain containing protein
WQO_RS10020	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS10025	COG0825	malonyl-CoA metabolic process
WQO_RS10025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WQO_RS10030	COG0477	Major facilitator Superfamily
WQO_RS10075	COG1070	Carbohydrate kinase
WQO_RS10090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WQO_RS10095	COG0358	DNA primase activity
WQO_RS10105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WQO_RS10115	COG2949	membrane
WQO_RS10160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WQO_RS10160	COG2146	nitrite reductase [NAD(P)H] activity
WQO_RS10165	COG2146	nitrite reductase [NAD(P)H] activity
WQO_RS10165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WQO_RS10185	COG3335	DDE superfamily endonuclease
WQO_RS10190	COG2801	Transposase and inactivated derivatives
WQO_RS10190	COG3415	Transposase
WQO_RS10200	COG3293	Transposase
WQO_RS10210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WQO_RS10210	COG0574	Belongs to the PEP-utilizing enzyme family
WQO_RS10235	COG0477	Major facilitator Superfamily
WQO_RS10240	COG1309	transcriptional regulator
WQO_RS10250	COG2066	Belongs to the glutaminase family
WQO_RS10265	COG3848	Pyruvate phosphate dikinase
WQO_RS10265	COG0574	Belongs to the PEP-utilizing enzyme family
WQO_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS10390	COG0423	glycine-tRNA ligase activity
WQO_RS10400	COG1121	(ABC) transporter
WQO_RS10405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WQO_RS10415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WQO_RS10420	COG1381	Involved in DNA repair and RecF pathway recombination
WQO_RS10435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WQO_RS10450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WQO_RS10465	COG2315	Protein conserved in bacteria
WQO_RS10475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WQO_RS10485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WQO_RS10495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WQO_RS10500	COG1234	tRNA 3'-trailer cleavage
WQO_RS10505	COG0537	adenosine 5'-monophosphoramidase activity
WQO_RS10520	COG0484	heat shock protein binding
WQO_RS10525	COG1420	regulation of RNA biosynthetic process
WQO_RS10565	COG1022	Amp-dependent synthetase and ligase
WQO_RS10570	COG0481	GTPase activity
WQO_RS10575	COG0268	Binds directly to 16S ribosomal RNA
WQO_RS10600	COG1234	tRNA 3'-trailer cleavage
WQO_RS10605	COG1555	photosystem II stabilization
WQO_RS10610	COG1307	EDD domain protein, DegV family
WQO_RS10620	COG0495	leucyl-tRNA aminoacylation
WQO_RS10630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WQO_RS10650	COG0588	phosphoglycerate mutase activity
WQO_RS10655	COG0799	negative regulation of ribosome biogenesis
WQO_RS10665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WQO_RS10670	COG0501	Belongs to the peptidase M48B family
WQO_RS10685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WQO_RS10695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WQO_RS10700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WQO_RS10720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WQO_RS10725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WQO_RS10730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WQO_RS10755	COG0673	inositol 2-dehydrogenase activity
WQO_RS10760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WQO_RS10765	COG1530	ribonuclease E activity
WQO_RS10790	COG0772	Belongs to the SEDS family
WQO_RS10795	COG0768	penicillin binding
WQO_RS10810	COG1077	Cell shape determining protein MreB Mrl
WQO_RS10815	COG0105	UTP biosynthetic process
WQO_RS10825	COG0285	dihydrofolate synthase activity
WQO_RS10830	COG0525	valine-tRNA ligase activity
WQO_RS10840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WQO_RS10845	COG0740	serine-type endopeptidase activity
WQO_RS10850	COG0740	serine-type endopeptidase activity
WQO_RS10855	COG0544	peptidyl-prolyl cis-trans isomerase activity
WQO_RS10870	COG3594	Acyltransferase
WQO_RS10880	COG0475	glutathione-regulated potassium exporter activity
WQO_RS10900	COG1113	amino acid transport
WQO_RS10910	COG1268	BioY protein
WQO_RS10915	COG1113	amino acid transport
WQO_RS10920	COG1113	amino acid transport
WQO_RS10925	COG0584	glycerophosphoryl diester phosphodiesterase
WQO_RS10930	COG0783	Belongs to the Dps family
WQO_RS10940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WQO_RS10945	COG0640	Transcriptional regulator
WQO_RS10960	COG0110	maltose O-acetyltransferase activity
WQO_RS10975	COG2252	PERMEase
WQO_RS10980	COG0675	Transposase, IS605 OrfB family
WQO_RS10995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WQO_RS11020	COG2337	Toxic component of a toxin-antitoxin (TA) module
WQO_RS11045	COG4266	Belongs to the allantoicase family
WQO_RS11070	COG3291	Pkd domain containing protein
WQO_RS11070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WQO_RS11080	COG0668	transmembrane transport
WQO_RS11085	COG1940	carbohydrate kinase activity
WQO_RS11095	COG1175	transmembrane transport
WQO_RS11100	COG0395	ABC-type sugar transport system, permease component
WQO_RS11105	COG1486	melibiose metabolic process
WQO_RS11120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS11155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WQO_RS11160	COG2346	COG2346, Truncated hemoglobins
WQO_RS11175	COG0577	efflux transmembrane transporter activity
WQO_RS11175	COG1136	(ABC) transporter
WQO_RS11205	COG0629	single-stranded DNA binding
WQO_RS11275	COG4585	Histidine kinase
WQO_RS11310	COG1131	(ABC) transporter
WQO_RS11330	COG3962	Belongs to the TPP enzyme family
WQO_RS11335	COG3718	enzyme involved in inositol metabolism
WQO_RS11345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WQO_RS11355	COG2318	DinB family
WQO_RS11370	COG2409	Drug exporters of the RND superfamily
WQO_RS11395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WQO_RS11440	COG2318	DinB family
WQO_RS11455	COG0673	inositol 2-dehydrogenase activity
WQO_RS11460	COG1609	Transcriptional regulator
WQO_RS11485	COG0515	serine threonine protein kinase
WQO_RS11510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WQO_RS11510	COG1672	PFAM Archaeal ATPase
WQO_RS11515	COG1404	Belongs to the peptidase S8 family
WQO_RS11530	COG0583	DNA-binding transcription factor activity
WQO_RS11535	COG1472	Belongs to the glycosyl hydrolase 3 family
WQO_RS11560	COG0028	Belongs to the TPP enzyme family
WQO_RS11570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WQO_RS11605	COG1674	ftsk spoiiie
WQO_RS11645	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WQO_RS11655	COG4106	trans-aconitate 2-methyltransferase activity
WQO_RS11665	COG0657	acetylesterase activity
WQO_RS11685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WQO_RS11700	COG1960	acyl-CoA dehydrogenase activity
WQO_RS11705	COG1946	Acyl-CoA thioesterase
WQO_RS11735	COG1309	transcriptional regulator
WQO_RS11740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WQO_RS11755	COG1960	acyl-CoA dehydrogenase activity
WQO_RS11775	COG2375	cellular response to nickel ion
WQO_RS11780	COG0076	glutamate decarboxylase activity
WQO_RS11785	COG3486	L-lysine 6-monooxygenase (NADPH) activity
WQO_RS11810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WQO_RS11815	COG0589	response to stress
WQO_RS11820	COG4977	sequence-specific DNA binding
WQO_RS11845	COG0395	ABC-type sugar transport system, permease component
WQO_RS11860	COG2985	domain, Protein
WQO_RS11865	COG2985	domain, Protein
WQO_RS11905	COG0588	phosphoglycerate mutase activity
WQO_RS11950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS11975	COG0765	amino acid transport
WQO_RS11980	COG0765	amino acid transport
WQO_RS11985	COG1126	abc transporter atp-binding protein
WQO_RS12000	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS12005	COG3397	chitin binding
WQO_RS12085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WQO_RS12090	COG2188	Transcriptional regulator
WQO_RS12100	COG1940	carbohydrate kinase activity
WQO_RS12105	COG0673	inositol 2-dehydrogenase activity
WQO_RS12110	COG4702	Belongs to the UPF0303 family
WQO_RS12120	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
WQO_RS12120	COG0706	membrane insertase activity
WQO_RS12130	COG3764	Sortase (surface protein transpeptidase)
WQO_RS12185	COG3335	DDE superfamily endonuclease
WQO_RS12220	COG3135	benzoate transporter
WQO_RS12225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS12240	COG2175	clavaminate synthase activity
WQO_RS12245	COG2267	carboxylic ester hydrolase activity
WQO_RS12255	COG2733	membrane
WQO_RS12285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WQO_RS12310	COG0477	Major facilitator Superfamily
WQO_RS12320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WQO_RS12330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WQO_RS12335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WQO_RS12340	COG1263	PTS System
WQO_RS12345	COG1263	PTS System
WQO_RS12380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS12395	COG1113	amino acid transport
WQO_RS12405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WQO_RS12415	COG1335	isochorismatase
WQO_RS12450	COG0277	FAD linked oxidase domain protein
WQO_RS12460	COG3185	4-Hydroxyphenylpyruvate dioxygenase
WQO_RS12470	COG1174	glycine betaine transport
WQO_RS12475	COG0517	IMP dehydrogenase activity
WQO_RS12475	COG1125	glycine betaine transport
WQO_RS12480	COG1174	glycine betaine transport
WQO_RS12485	COG1732	Glycine betaine
WQO_RS12505	COG3480	Lon protease (S16) C-terminal proteolytic domain
WQO_RS12515	COG1061	Type III restriction enzyme res subunit
WQO_RS12520	COG3654	unkown
WQO_RS12530	COG2814	Major facilitator Superfamily
WQO_RS12575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WQO_RS12580	COG0395	ABC-type sugar transport system, permease component
WQO_RS12600	COG1678	Uncharacterized ACR, COG1678
WQO_RS12605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WQO_RS12620	COG0776	regulation of translation
WQO_RS12630	COG3973	AAA domain
WQO_RS12665	COG2223	nitrite transmembrane transporter activity
WQO_RS12685	COG0583	DNA-binding transcription factor activity
WQO_RS12695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WQO_RS12700	COG0793	Belongs to the peptidase S41A family
WQO_RS12705	COG2177	Part of the ABC transporter FtsEX involved in
WQO_RS12710	COG2884	Cell division ATP-binding protein ftsE
WQO_RS12725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WQO_RS12730	COG0515	serine threonine protein kinase
WQO_RS12735	COG0515	serine threonine protein kinase
WQO_RS12745	COG1653	transport
WQO_RS12750	COG1175	transmembrane transport
WQO_RS12755	COG0395	ABC-type sugar transport system, permease component
WQO_RS12760	COG1442	glycosyl transferase family 8
WQO_RS12760	COG1216	Glycosyl transferase, family 2
WQO_RS12765	COG0438	transferase activity, transferring glycosyl groups
WQO_RS12770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WQO_RS12775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WQO_RS12785	COG2226	methyltransferase
WQO_RS12785	COG1073	alpha beta
WQO_RS12790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WQO_RS12795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WQO_RS12815	COG1134	teichoic acid transport
WQO_RS12820	COG2902	Dehydrogenase
WQO_RS12845	COG0653	protein targeting
WQO_RS12860	COG2197	response regulator
WQO_RS12865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WQO_RS12875	COG0823	Involved in the tonB-independent uptake of proteins
WQO_RS12880	COG5000	phosphorelay sensor kinase activity
WQO_RS12880	COG5002	protein histidine kinase activity
WQO_RS12885	COG0745	RESPONSE REGULATOR receiver
WQO_RS12890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
WQO_RS12910	COG0714	Associated with various cellular activities
WQO_RS12950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WQO_RS12970	COG2835	tetraacyldisaccharide 4'-kinase activity
WQO_RS12975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WQO_RS13010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WQO_RS13015	COG0778	Nitroreductase
WQO_RS13015	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
WQO_RS13025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WQO_RS13040	COG1316	TRANSCRIPTIONal
WQO_RS13045	COG1316	TRANSCRIPTIONal
WQO_RS13060	COG1316	TRANSCRIPTIONal
WQO_RS13070	COG1316	TRANSCRIPTIONal
WQO_RS13115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WQO_RS13150	COG2205	protein histidine kinase activity
WQO_RS13155	COG0745	RESPONSE REGULATOR receiver
WQO_RS13160	COG3104	oligopeptide transport
WQO_RS13190	COG1366	Belongs to the anti-sigma-factor antagonist family
WQO_RS13195	COG1191	sigma factor activity
WQO_RS13205	COG1228	amidohydrolase
WQO_RS13215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WQO_RS13220	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WQO_RS13225	COG0531	amino acid
WQO_RS13265	COG2755	lipolytic protein G-D-S-L family
WQO_RS13270	COG0183	Belongs to the thiolase family
WQO_RS13295	COG0577	efflux transmembrane transporter activity
WQO_RS13295	COG1136	(ABC) transporter
WQO_RS13300	COG1136	(ABC) transporter
WQO_RS13300	COG0577	efflux transmembrane transporter activity
WQO_RS13305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WQO_RS13310	COG1252	NADH dehydrogenase
WQO_RS13330	COG0148	phosphopyruvate hydratase activity
WQO_RS13340	COG1652	LysM domain
WQO_RS13360	COG2815	serine threonine protein kinase
WQO_RS13360	COG0515	serine threonine protein kinase
WQO_RS13370	COG1335	isochorismatase
WQO_RS13435	COG1473	amidohydrolase
WQO_RS13490	COG3903	Transcriptional regulator
WQO_RS13490	COG3629	intracellular signal transduction
WQO_RS13500	COG0577	efflux transmembrane transporter activity
WQO_RS13505	COG1136	(ABC) transporter
WQO_RS13510	COG0477	Major facilitator Superfamily
WQO_RS13515	COG0640	Transcriptional regulator
WQO_RS13520	COG0346	lactoylglutathione lyase activity
WQO_RS13555	COG2124	cytochrome p450
WQO_RS13560	COG2124	cytochrome p450
WQO_RS13565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS13570	COG0667	Aldo Keto reductase
WQO_RS13600	COG4585	Histidine kinase
WQO_RS13610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WQO_RS13615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WQO_RS13620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WQO_RS13625	COG0193	aminoacyl-tRNA hydrolase activity
WQO_RS13635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WQO_RS13660	COG4106	trans-aconitate 2-methyltransferase activity
WQO_RS13665	COG1846	Transcriptional regulator
WQO_RS13670	COG2197	response regulator
WQO_RS13680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WQO_RS13695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WQO_RS13725	COG0488	(ABC) transporter
WQO_RS13745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WQO_RS13750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WQO_RS13760	COG0084	hydrolase, TatD family'
WQO_RS13785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WQO_RS13815	COG0442	prolyl-tRNA aminoacylation
WQO_RS13840	COG1115	amino acid carrier protein
WQO_RS13850	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
WQO_RS13855	COG0519	Catalyzes the synthesis of GMP from XMP
WQO_RS13875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WQO_RS13880	COG1122	ATPase activity
WQO_RS13890	COG0310	cobalt ion transport
WQO_RS13900	COG2409	Drug exporters of the RND superfamily
WQO_RS13910	COG4946	Tricorn protease homolog
WQO_RS13910	COG0793	Belongs to the peptidase S41A family
WQO_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS13930	COG2267	carboxylic ester hydrolase activity
WQO_RS13935	COG2072	flavoprotein involved in K transport
WQO_RS13945	COG0708	Exodeoxyribonuclease III
WQO_RS13975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WQO_RS13990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WQO_RS13995	COG0521	Mo-molybdopterin cofactor biosynthetic process
WQO_RS14000	COG0315	cyclic pyranopterin monophosphate synthase activity
WQO_RS14010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WQO_RS14015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WQO_RS14040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WQO_RS14050	COG1970	mechanosensitive ion channel activity
WQO_RS14070	COG0437	4 iron, 4 sulfur cluster binding
WQO_RS14075	COG0243	molybdopterin cofactor binding
WQO_RS14095	COG0477	Major facilitator Superfamily
WQO_RS14115	COG3293	Transposase
WQO_RS14125	COG3384	dioxygenase
WQO_RS14130	COG1846	Transcriptional regulator
WQO_RS14205	COG1686	Belongs to the peptidase S11 family
WQO_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS14270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WQO_RS14280	COG0768	penicillin binding
WQO_RS14320	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WQO_RS14345	COG0667	Aldo Keto reductase
WQO_RS14390	COG3940	Belongs to the glycosyl hydrolase 43 family
WQO_RS14400	COG1309	transcriptional regulator
WQO_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS14425	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
WQO_RS14435	COG0183	Belongs to the thiolase family
WQO_RS14440	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS14450	COG3647	Membrane
WQO_RS14455	COG1309	transcriptional regulator
WQO_RS14520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WQO_RS14530	COG0163	prenyltransferase activity
WQO_RS14545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WQO_RS14555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WQO_RS14560	COG1333	cytochrome c biogenesis protein
WQO_RS14565	COG0785	Cytochrome C biogenesis protein
WQO_RS14590	COG0406	alpha-ribazole phosphatase activity
WQO_RS14595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WQO_RS14625	COG1116	anion transmembrane transporter activity
WQO_RS14640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WQO_RS14660	COG2188	Transcriptional regulator
WQO_RS14665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WQO_RS14670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WQO_RS14675	COG1690	Belongs to the RtcB family
WQO_RS14705	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WQO_RS14710	COG0018	arginyl-trna synthetase
WQO_RS14725	COG0789	Transcriptional regulator
WQO_RS14755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WQO_RS14785	COG0113	porphobilinogen synthase activity
WQO_RS14790	COG1648	precorrin-2 dehydrogenase activity
WQO_RS14790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WQO_RS14795	COG0181	hydroxymethylbilane synthase activity
WQO_RS14800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WQO_RS14805	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
WQO_RS14855	COG2223	nitrite transmembrane transporter activity
WQO_RS14860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WQO_RS14880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WQO_RS14890	COG1129	ABC transporter
WQO_RS14890	COG0842	Transport permease protein
WQO_RS14900	COG4991	sh3 domain protein
WQO_RS14905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WQO_RS14905	COG0515	serine threonine protein kinase
WQO_RS14910	COG0129	dihydroxy-acid dehydratase activity
WQO_RS14920	COG1082	Xylose isomerase domain protein TIM barrel
WQO_RS14925	COG0248	Ppx GppA phosphatase
WQO_RS14945	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
WQO_RS14955	COG1194	a g-specific adenine glycosylase
WQO_RS14960	COG1595	DNA-templated transcription, initiation
WQO_RS14970	COG0745	RESPONSE REGULATOR receiver
WQO_RS14975	COG2205	protein histidine kinase activity
WQO_RS14980	COG0739	heme binding
WQO_RS15010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WQO_RS15030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WQO_RS15040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WQO_RS15045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WQO_RS15070	COG2197	response regulator
WQO_RS15085	COG0649	NAD binding
WQO_RS15100	COG1174	glycine betaine transport
WQO_RS15105	COG1174	glycine betaine transport
WQO_RS15110	COG0517	IMP dehydrogenase activity
WQO_RS15110	COG1125	glycine betaine transport
WQO_RS15120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WQO_RS15120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WQO_RS15135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WQO_RS15140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WQO_RS15150	COG0302	gtp cyclohydrolase
WQO_RS15165	COG0037	tRNA processing
WQO_RS15175	COG2027	D-alanyl-D-alanine carboxypeptidase
WQO_RS15180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WQO_RS15190	COG0586	Pfam SNARE associated Golgi protein
WQO_RS15195	COG0393	Putative heavy-metal-binding
WQO_RS15205	COG0655	NAD(P)H dehydrogenase (quinone) activity
WQO_RS15210	COG0076	glutamate decarboxylase activity
WQO_RS15240	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS15285	COG1595	DNA-templated transcription, initiation
WQO_RS15320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WQO_RS15345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WQO_RS15370	COG0666	response to abiotic stimulus
WQO_RS15380	COG4585	Histidine kinase
WQO_RS15400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WQO_RS15410	COG2801	Transposase and inactivated derivatives
WQO_RS15410	COG3415	Transposase
WQO_RS15425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WQO_RS15475	COG2770	Histidine kinase
WQO_RS15475	COG2208	phosphoserine phosphatase activity
WQO_RS15520	COG3842	ATPase activity
WQO_RS15530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WQO_RS15545	COG0215	cysteine-tRNA ligase activity
WQO_RS15550	COG3467	pyridoxamine 5'-phosphate
WQO_RS15555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WQO_RS15560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WQO_RS15565	COG1329	Transcriptional regulator
WQO_RS15580	COG5002	protein histidine kinase activity
WQO_RS15595	COG0588	phosphoglycerate mutase activity
WQO_RS15650	COG0438	transferase activity, transferring glycosyl groups
WQO_RS15685	COG0789	Transcriptional regulator
WQO_RS15720	COG4552	Acetyltransferase involved in intracellular survival and related
WQO_RS15735	COG1490	D-aminoacyl-tRNA deacylase activity
WQO_RS15745	COG0735	belongs to the Fur family
WQO_RS15750	COG3485	protocatechuate 3,4-dioxygenase
WQO_RS15785	COG2897	thiosulfate sulfurtransferase activity
WQO_RS15810	COG0745	RESPONSE REGULATOR receiver
WQO_RS15815	COG1609	Transcriptional regulator
WQO_RS15820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WQO_RS15850	COG0739	heme binding
WQO_RS15870	COG4977	sequence-specific DNA binding
WQO_RS15885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WQO_RS15895	COG0737	Belongs to the 5'-nucleotidase family
WQO_RS15900	COG0456	acetyltransferase
WQO_RS15905	COG1725	Transcriptional regulator
WQO_RS15930	COG0494	nUDIX hydrolase
WQO_RS15930	COG0406	alpha-ribazole phosphatase activity
WQO_RS15935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WQO_RS15955	COG0306	phosphate transporter
WQO_RS15965	COG1937	Protein conserved in bacteria
WQO_RS15985	COG0671	phosphoesterase, PA-phosphatase related
WQO_RS15990	COG1196	nuclear chromosome segregation
WQO_RS15990	COG0739	heme binding
WQO_RS15990	COG0741	lytic transglycosylase activity
WQO_RS16060	COG1131	(ABC) transporter
WQO_RS16070	COG4585	Histidine kinase
WQO_RS16075	COG2197	response regulator
WQO_RS16095	COG1846	Transcriptional regulator
WQO_RS16110	COG1252	NADH dehydrogenase
WQO_RS16135	COG0579	oxidoreductase
WQO_RS16140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WQO_RS16150	COG0667	Aldo Keto reductase
WQO_RS16155	COG0741	lytic transglycosylase activity
WQO_RS16155	COG0739	heme binding
WQO_RS16155	COG1196	nuclear chromosome segregation
WQO_RS16165	COG0789	Transcriptional regulator
WQO_RS16175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WQO_RS16180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WQO_RS16195	COG1191	sigma factor activity
WQO_RS16205	COG0596	Alpha beta hydrolase
WQO_RS16225	COG0513	Belongs to the DEAD box helicase family
WQO_RS16235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WQO_RS16240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WQO_RS16270	COG0785	Cytochrome C biogenesis protein
WQO_RS16275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WQO_RS16275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WQO_RS16285	COG1643	Atp-dependent helicase
WQO_RS16305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WQO_RS16315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WQO_RS16335	COG0741	lytic transglycosylase activity
WQO_RS16335	COG0739	heme binding
WQO_RS16335	COG1196	nuclear chromosome segregation
WQO_RS16345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WQO_RS16350	COG0047	phosphoribosylformylglycinamidine synthase activity
WQO_RS16355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WQO_RS16375	COG1131	(ABC) transporter
WQO_RS16390	COG2197	response regulator
WQO_RS16400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WQO_RS16415	COG0151	Belongs to the GarS family
WQO_RS16430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WQO_RS16440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WQO_RS16480	COG0494	nUDIX hydrolase
WQO_RS16485	COG3634	alkyl hydroperoxide reductase activity
WQO_RS16515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WQO_RS16550	COG3335	DDE superfamily endonuclease
WQO_RS16630	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
WQO_RS16650	COG0490	domain, Protein
WQO_RS16655	COG0475	glutathione-regulated potassium exporter activity
WQO_RS16660	COG0181	hydroxymethylbilane synthase activity
WQO_RS16685	COG2255	four-way junction helicase activity
WQO_RS16695	COG0180	Tryptophanyl-tRNA synthetase
WQO_RS16700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS16715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WQO_RS16715	COG1672	PFAM Archaeal ATPase
WQO_RS16735	COG0431	NADPH-dependent FMN reductase
WQO_RS16765	COG2304	oxidoreductase activity
WQO_RS16770	COG2205	protein histidine kinase activity
WQO_RS16775	COG0745	RESPONSE REGULATOR receiver
WQO_RS16780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WQO_RS16790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WQO_RS16805	COG1741	Belongs to the pirin family
WQO_RS16815	COG1960	acyl-CoA dehydrogenase activity
WQO_RS16820	COG1362	aminopeptidase activity
WQO_RS16840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WQO_RS16850	COG2271	Major facilitator Superfamily
WQO_RS16855	COG1802	Transcriptional regulator
WQO_RS16880	COG0508	dehydrogenase complex catalyzes the overall conversion of
WQO_RS16885	COG0022	dehydrogenase e1 component
WQO_RS16910	COG0515	serine threonine protein kinase
WQO_RS16915	COG0515	serine threonine protein kinase
WQO_RS16970	COG1522	sequence-specific DNA binding
WQO_RS16975	COG1309	transcriptional regulator
WQO_RS17000	COG3396	Phenylacetate-CoA oxygenase
WQO_RS17005	COG3460	Phenylacetate-CoA oxygenase
WQO_RS17010	COG3396	Phenylacetate-CoA oxygenase
WQO_RS17015	COG2151	metal-sulfur cluster biosynthetic enzyme
WQO_RS17020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WQO_RS17045	COG1733	regulation of RNA biosynthetic process
WQO_RS17050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WQO_RS17065	COG1716	ATPase activity
WQO_RS17070	COG1716	ATPase activity
WQO_RS17085	COG0768	penicillin binding
WQO_RS17090	COG0515	serine threonine protein kinase
WQO_RS17095	COG3764	Sortase (surface protein transpeptidase)
WQO_RS17100	COG3764	Sortase (surface protein transpeptidase)
WQO_RS17115	COG3764	Sortase (surface protein transpeptidase)
WQO_RS17130	COG0705	Rhomboid family
WQO_RS17160	COG0515	serine threonine protein kinase
WQO_RS17190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WQO_RS17200	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
WQO_RS17205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WQO_RS17210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WQO_RS17215	COG0592	DNA-directed DNA polymerase activity
WQO_RS17225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WQO_RS17235	COG0706	membrane insertase activity
WQO_RS17245	COG0357	Ribosomal RNA small subunit methyltransferase G
WQO_RS17250	COG1192	Involved in chromosome partitioning
WQO_RS17265	COG3118	belongs to the thioredoxin family
WQO_RS17270	COG0492	ferredoxin-NADP+ reductase activity
WQO_RS17280	COG1595	DNA-templated transcription, initiation
WQO_RS17285	COG2815	serine threonine protein kinase
WQO_RS17285	COG0515	serine threonine protein kinase
WQO_RS17300	COG0617	tRNA 3'-terminal CCA addition
WQO_RS17320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WQO_RS17345	COG0360	Binds together with S18 to 16S ribosomal RNA
WQO_RS17350	COG0629	single-stranded DNA binding
WQO_RS17355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WQO_RS17360	COG0359	binds to the 23S rRNA
WQO_RS17370	COG0305	Participates in initiation and elongation during chromosome replication
WQO_RS17395	COG2814	Major facilitator Superfamily
WQO_RS17415	COG0626	cystathionine gamma-synthase activity
WQO_RS17420	COG1950	PFAM Membrane protein of
WQO_RS17425	COG0662	Cupin 2, conserved barrel domain protein
WQO_RS17450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WQO_RS17460	COG3152	Membrane
WQO_RS17470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WQO_RS17475	COG1609	Transcriptional regulator
WQO_RS17480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WQO_RS17485	COG1271	oxidase subunit
WQO_RS17490	COG1294	oxidase, subunit
WQO_RS17495	COG4988	ABC transporter
WQO_RS17505	COG0561	phosphatase activity
WQO_RS17515	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
WQO_RS17520	COG0789	Transcriptional regulator
WQO_RS17535	COG1131	(ABC) transporter
WQO_RS17560	COG0561	phosphatase activity
WQO_RS17565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WQO_RS17575	COG2837	iron assimilation
WQO_RS17580	COG2372	response to copper ion
WQO_RS17590	COG1999	signal sequence binding
WQO_RS17610	COG0006	proline dipeptidase activity
WQO_RS17630	COG0653	protein targeting
WQO_RS17645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WQO_RS17760	COG3335	DDE superfamily endonuclease
WQO_RS17780	COG3903	Transcriptional regulator
WQO_RS17780	COG3629	intracellular signal transduction
WQO_RS17790	COG3693	PFAM glycoside hydrolase, family 10
WQO_RS17805	COG1960	acyl-CoA dehydrogenase activity
WQO_RS17830	COG1595	DNA-templated transcription, initiation
WQO_RS17835	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS17860	COG1252	NADH dehydrogenase
WQO_RS17865	COG1595	DNA-templated transcription, initiation
WQO_RS17885	COG0745	RESPONSE REGULATOR receiver
WQO_RS17890	COG2205	protein histidine kinase activity
WQO_RS17900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WQO_RS17915	COG0477	Major facilitator Superfamily
WQO_RS17930	COG3467	pyridoxamine 5'-phosphate
WQO_RS17935	COG2353	YceI-like domain
WQO_RS17965	COG1191	sigma factor activity
WQO_RS17970	COG1191	sigma factor activity
WQO_RS17995	COG2154	pterin-4-alpha-carbinolamine dehydratase
WQO_RS18010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WQO_RS18035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WQO_RS18060	COG4941	Belongs to the sigma-70 factor family
WQO_RS18080	COG2268	Band 7 protein
WQO_RS18140	COG1278	Cold shock
WQO_RS18145	COG0513	Belongs to the DEAD box helicase family
WQO_RS18155	COG3594	Acyltransferase
WQO_RS18160	COG2409	Drug exporters of the RND superfamily
WQO_RS18170	COG0475	glutathione-regulated potassium exporter activity
WQO_RS18180	COG0531	amino acid
WQO_RS18205	COG3585	molybdate ion transport
WQO_RS18225	COG1024	Enoyl-CoA hydratase
WQO_RS18230	COG2124	cytochrome p450
WQO_RS18235	COG2124	cytochrome p450
WQO_RS18375	COG2897	thiosulfate sulfurtransferase activity
WQO_RS18385	COG0626	cystathionine gamma-synthase activity
WQO_RS18425	COG0717	Belongs to the dCTP deaminase family
WQO_RS18445	COG2181	nitrate reductase activity
WQO_RS18445	COG0247	lactate metabolic process
WQO_RS18450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WQO_RS18455	COG0443	Heat shock 70 kDa protein
WQO_RS18460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WQO_RS18465	COG0484	heat shock protein binding
WQO_RS18470	COG0789	Transcriptional regulator
WQO_RS18490	COG2197	response regulator
WQO_RS18500	COG1132	(ABC) transporter
WQO_RS18510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WQO_RS18530	COG2226	methyltransferase
WQO_RS18535	COG0612	Peptidase, M16
WQO_RS18575	COG0542	response to heat
WQO_RS18600	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WQO_RS18615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WQO_RS18620	COG0191	fructose-bisphosphate aldolase activity
WQO_RS18625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WQO_RS18630	COG0477	Major facilitator Superfamily
WQO_RS18645	COG3844	kynureninase activity
WQO_RS18655	COG0702	epimerase
WQO_RS18660	COG4585	Histidine kinase
WQO_RS18665	COG2197	response regulator
WQO_RS18690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WQO_RS18705	COG0592	DNA-directed DNA polymerase activity
WQO_RS18755	COG2015	COG2015, Alkyl sulfatase and related hydrolases
WQO_RS18805	COG3226	Transcriptional regulator
WQO_RS18830	COG0738	Major facilitator superfamily
WQO_RS18835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WQO_RS18835	COG0515	serine threonine protein kinase
WQO_RS18845	COG0693	protein deglycase activity
WQO_RS18850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WQO_RS18855	COG1802	Transcriptional regulator
WQO_RS18870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WQO_RS18875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WQO_RS18900	COG1595	DNA-templated transcription, initiation
WQO_RS18935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WQO_RS18945	COG2755	lipolytic protein G-D-S-L family
WQO_RS18990	COG1674	ftsk spoiiie
WQO_RS18990	COG1196	nuclear chromosome segregation
WQO_RS19005	COG0270	DNA (cytosine-5-)-methyltransferase activity
WQO_RS19085	COG2188	Transcriptional regulator
WQO_RS19170	COG1408	metallophosphoesterase
WQO_RS19175	COG1610	YqeY-like protein
WQO_RS19180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WQO_RS19190	COG0003	Pfam Anion-transporting ATPase
WQO_RS19210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WQO_RS19235	COG2267	carboxylic ester hydrolase activity
WQO_RS19245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WQO_RS19250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WQO_RS19310	COG1205	dead DEAH box helicase
WQO_RS19310	COG1111	helicase
WQO_RS19315	COG1366	Belongs to the anti-sigma-factor antagonist family
WQO_RS19325	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WQO_RS19335	COG2890	protein-(glutamine-N5) methyltransferase activity
WQO_RS19345	COG1754	DNA topoisomerase type I activity
WQO_RS19345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WQO_RS19350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WQO_RS19355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WQO_RS19405	COG1278	Cold shock
WQO_RS19410	COG0513	Belongs to the DEAD box helicase family
WQO_RS19475	COG1073	alpha beta
WQO_RS19490	COG0789	Transcriptional regulator
WQO_RS19505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WQO_RS19510	COG2197	response regulator
WQO_RS19515	COG4585	Histidine kinase
WQO_RS19520	COG0577	efflux transmembrane transporter activity
WQO_RS19520	COG1136	(ABC) transporter
WQO_RS19525	COG0577	efflux transmembrane transporter activity
WQO_RS19535	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WQO_RS19540	COG0463	Glycosyl transferase, family 2
WQO_RS19585	COG1132	(ABC) transporter
WQO_RS19590	COG1595	DNA-templated transcription, initiation
WQO_RS19620	COG3321	synthase
WQO_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS19620	COG0604	alcohol dehydrogenase
WQO_RS19640	COG1215	transferase activity, transferring glycosyl groups
WQO_RS19665	COG0395	ABC-type sugar transport system, permease component
WQO_RS19670	COG1175	transmembrane transport
WQO_RS19700	COG4251	negative regulation of phosphorylation
WQO_RS19720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WQO_RS19720	COG1263	PTS System
WQO_RS19725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
WQO_RS19730	COG1737	Transcriptional regulator
WQO_RS19765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
WQO_RS19790	COG3973	AAA domain
WQO_RS19800	COG1061	Type III restriction enzyme res subunit
WQO_RS19820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WQO_RS19835	COG1278	Cold shock
WQO_RS19845	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
WQO_RS19850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WQO_RS19860	COG2814	Major facilitator Superfamily
WQO_RS19880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WQO_RS19890	COG2252	PERMEase
WQO_RS19920	COG0667	Aldo Keto reductase
WQO_RS19935	COG0671	phosphoesterase, PA-phosphatase related
WQO_RS19955	COG2267	carboxylic ester hydrolase activity
WQO_RS19965	COG0515	serine threonine protein kinase
WQO_RS19970	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS19975	COG3293	Transposase
WQO_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS20070	COG1132	(ABC) transporter
WQO_RS20075	COG1132	(ABC) transporter
WQO_RS20095	COG2197	response regulator
WQO_RS20110	COG1309	transcriptional regulator
WQO_RS20175	COG1335	isochorismatase
WQO_RS20190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WQO_RS20220	COG2205	protein histidine kinase activity
WQO_RS20225	COG0277	FAD linked oxidase domain protein
WQO_RS20225	COG0247	lactate metabolic process
WQO_RS20230	COG0583	DNA-binding transcription factor activity
WQO_RS20235	COG5006	permease, DMT superfamily
WQO_RS20240	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
WQO_RS20250	COG1051	belongs to the nudix hydrolase family
WQO_RS20255	COG2318	DinB family
WQO_RS20270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WQO_RS20285	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS20290	COG1024	Enoyl-CoA hydratase
WQO_RS20300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WQO_RS20315	COG4106	trans-aconitate 2-methyltransferase activity
WQO_RS20330	COG0259	pyridoxamine-phosphate oxidase activity
WQO_RS20345	COG0577	efflux transmembrane transporter activity
WQO_RS20345	COG1136	(ABC) transporter
WQO_RS20350	COG1136	(ABC) transporter
WQO_RS20350	COG0577	efflux transmembrane transporter activity
WQO_RS20365	COG0745	RESPONSE REGULATOR receiver
WQO_RS20370	COG2205	protein histidine kinase activity
WQO_RS20375	COG4821	SIS domain
WQO_RS20385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WQO_RS20395	COG1131	(ABC) transporter
WQO_RS20440	COG1366	Belongs to the anti-sigma-factor antagonist family
WQO_RS20450	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS20460	COG1960	acyl-CoA dehydrogenase activity
WQO_RS20465	COG1960	acyl-CoA dehydrogenase activity
WQO_RS20480	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS20520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WQO_RS20525	COG1024	Enoyl-CoA hydratase
WQO_RS20550	COG2072	flavoprotein involved in K transport
WQO_RS20555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS20575	COG0501	Belongs to the peptidase M48B family
WQO_RS20580	COG0259	pyridoxamine-phosphate oxidase activity
WQO_RS20600	COG1960	acyl-CoA dehydrogenase activity
WQO_RS20610	COG1309	transcriptional regulator
WQO_RS20650	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS20680	COG1278	Cold shock
WQO_RS20685	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
WQO_RS20695	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WQO_RS20725	COG2175	clavaminate synthase activity
WQO_RS20730	COG2226	methyltransferase
WQO_RS20770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS20775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS20780	COG0649	NAD binding
WQO_RS20790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WQO_RS20795	COG1034	ATP synthesis coupled electron transport
WQO_RS20800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WQO_RS20805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS20810	COG0839	Belongs to the complex I subunit 6 family
WQO_RS20815	COG0713	ATP synthesis coupled electron transport
WQO_RS20820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WQO_RS20830	COG1007	ATP synthesis coupled electron transport
WQO_RS20845	COG0596	Alpha beta hydrolase
WQO_RS20855	COG2197	response regulator
WQO_RS20880	COG0179	Fumarylacetoacetate (FAA) hydrolase
WQO_RS20890	COG3104	oligopeptide transport
WQO_RS20895	COG0142	geranyltranstransferase activity
WQO_RS20905	COG1131	(ABC) transporter
WQO_RS20935	COG0561	phosphatase activity
WQO_RS20980	COG1064	alcohol dehydrogenase
WQO_RS21020	COG0702	epimerase
WQO_RS21025	COG1733	regulation of RNA biosynthetic process
WQO_RS21030	COG1013	pyruvate-flavodoxin oxidoreductase activity
WQO_RS21035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WQO_RS21035	COG0674	pyruvate-flavodoxin oxidoreductase activity
WQO_RS21055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS21060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS21065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS21070	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WQO_RS21075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WQO_RS21080	COG0839	Belongs to the complex I subunit 6 family
WQO_RS21085	COG0713	ATP synthesis coupled electron transport
WQO_RS21090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WQO_RS21100	COG1007	ATP synthesis coupled electron transport
WQO_RS21110	COG0501	Belongs to the peptidase M48B family
WQO_RS21115	COG3304	Inner membrane component domain
WQO_RS21130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WQO_RS21135	COG1666	GTP binding
WQO_RS21205	COG2188	Transcriptional regulator
WQO_RS21210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WQO_RS21215	COG0702	epimerase
WQO_RS21235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WQO_RS21240	COG2030	dehydratase
WQO_RS21250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WQO_RS21265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WQO_RS21270	COG0436	Aminotransferase
WQO_RS21290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WQO_RS21295	COG0081	regulation of translation
WQO_RS21305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WQO_RS21310	COG0222	ribosome binding
WQO_RS21315	COG0085	RNA polymerase activity
WQO_RS21320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WQO_RS21325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WQO_RS21330	COG0049	tRNA binding
WQO_RS21335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WQO_RS21340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WQO_RS21360	COG0051	transcription antitermination factor activity, RNA binding
WQO_RS21365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WQO_RS21370	COG0088	Forms part of the polypeptide exit tunnel
WQO_RS21375	COG0089	rRNA binding
WQO_RS21380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WQO_RS21385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WQO_RS21390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WQO_RS21395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WQO_RS21400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WQO_RS21405	COG0255	Belongs to the universal ribosomal protein uL29 family
WQO_RS21410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WQO_RS21415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WQO_RS21420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WQO_RS21425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WQO_RS21430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WQO_RS21435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WQO_RS21440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WQO_RS21445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WQO_RS21450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WQO_RS21460	COG0200	Binds to the 23S rRNA
WQO_RS21470	COG0563	adenylate kinase activity
WQO_RS21480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WQO_RS21485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WQO_RS21490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WQO_RS21495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WQO_RS21500	COG0202	RNA polymerase activity
WQO_RS21505	COG0203	ribosomal protein L17
WQO_RS21510	COG0101	tRNA pseudouridine synthase activity
WQO_RS21520	COG0488	(ABC) transporter
WQO_RS21525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WQO_RS21530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WQO_RS21535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WQO_RS21540	COG2770	Histidine kinase
WQO_RS21540	COG2208	phosphoserine phosphatase activity
WQO_RS21550	COG1072	(Pantothenic acid kinase))
WQO_RS21585	COG0596	Alpha beta hydrolase
WQO_RS21590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS21595	COG3795	YCII-related domain
WQO_RS21600	COG4941	Belongs to the sigma-70 factor family
WQO_RS21620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WQO_RS21625	COG0736	holo-[acyl-carrier-protein] synthase activity
WQO_RS21630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WQO_RS21630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WQO_RS21635	COG3189	MarR family transcriptional regulator
WQO_RS21640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WQO_RS21650	COG0802	atpase or kinase
WQO_RS21675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WQO_RS21695	COG0726	polysaccharide deacetylase
WQO_RS21705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WQO_RS21720	COG0395	ABC-type sugar transport system, permease component
WQO_RS21735	COG1609	Transcriptional regulator
WQO_RS21750	COG0583	DNA-binding transcription factor activity
WQO_RS21765	COG1595	DNA-templated transcription, initiation
WQO_RS21775	COG0516	GMP reductase activity
WQO_RS21805	COG0515	serine threonine protein kinase
WQO_RS21810	COG2815	serine threonine protein kinase
WQO_RS21810	COG0515	serine threonine protein kinase
WQO_RS21815	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS21835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WQO_RS21835	COG0519	Catalyzes the synthesis of GMP from XMP
WQO_RS21875	COG2197	response regulator
WQO_RS21900	COG0739	heme binding
WQO_RS21910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WQO_RS21930	COG0714	Associated with various cellular activities
WQO_RS21940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
WQO_RS21955	COG0045	succinate-CoA ligase (ADP-forming) activity
WQO_RS21985	COG0138	bifunctional purine biosynthesis protein purh
WQO_RS22000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WQO_RS22015	COG0039	L-malate dehydrogenase activity
WQO_RS22020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WQO_RS22025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS22035	COG0754	glutathionylspermidine amidase activity
WQO_RS22040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WQO_RS22045	COG0180	Tryptophanyl-tRNA synthetase
WQO_RS22065	COG1295	ribonuclease BN
WQO_RS22070	COG1686	Belongs to the peptidase S11 family
WQO_RS22080	COG1408	metallophosphoesterase
WQO_RS22115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WQO_RS22130	COG2009	succinate dehydrogenase
WQO_RS22185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WQO_RS22190	COG1595	DNA-templated transcription, initiation
WQO_RS22210	COG1216	Glycosyl transferase, family 2
WQO_RS22240	COG1216	Glycosyl transferase, family 2
WQO_RS22250	COG1083	cytidylyl-transferase
WQO_RS22255	COG2089	acid synthase
WQO_RS22270	COG1473	amidohydrolase
WQO_RS22270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
WQO_RS22275	COG1744	ABC transporter substrate-binding protein PnrA-like
WQO_RS22280	COG3845	ABC transporter
WQO_RS22285	COG4603	Belongs to the binding-protein-dependent transport system permease family
WQO_RS22290	COG1079	Belongs to the binding-protein-dependent transport system permease family
WQO_RS22310	COG1404	Belongs to the peptidase S8 family
WQO_RS22330	COG2814	Major facilitator Superfamily
WQO_RS22335	COG0583	DNA-binding transcription factor activity
WQO_RS22350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WQO_RS22375	COG2205	protein histidine kinase activity
WQO_RS22380	COG0745	RESPONSE REGULATOR receiver
WQO_RS22385	COG1595	DNA-templated transcription, initiation
WQO_RS22405	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS22410	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS22425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WQO_RS22455	COG4770	biotin carboxylase activity
WQO_RS22465	COG0424	maF-like protein
WQO_RS22475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WQO_RS22490	COG1024	Enoyl-CoA hydratase
WQO_RS22515	COG1376	ErfK ybiS ycfS ynhG family protein
WQO_RS22535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WQO_RS22545	COG1396	sequence-specific DNA binding
WQO_RS22550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WQO_RS22590	COG0745	RESPONSE REGULATOR receiver
WQO_RS22595	COG2205	protein histidine kinase activity
WQO_RS22595	COG3437	response regulator, receiver
WQO_RS22595	COG4999	Histidine kinase
WQO_RS22595	COG3850	Histidine kinase
WQO_RS22605	COG2172	sigma factor antagonist activity
WQO_RS22610	COG1366	Belongs to the anti-sigma-factor antagonist family
WQO_RS22615	COG1366	Belongs to the anti-sigma-factor antagonist family
WQO_RS22620	COG2255	four-way junction helicase activity
WQO_RS22625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WQO_RS22640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WQO_RS22650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WQO_RS22665	COG0154	amidase activity
WQO_RS22670	COG1309	transcriptional regulator
WQO_RS22680	COG1331	Highly conserved protein containing a thioredoxin domain
WQO_RS22690	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
WQO_RS22700	COG0436	Aminotransferase
WQO_RS22720	COG1733	regulation of RNA biosynthetic process
WQO_RS22740	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WQO_RS22755	COG1414	Transcriptional regulator
WQO_RS22760	COG0251	oxidation-reduction process
WQO_RS22765	COG2610	gluconate transmembrane transporter activity
WQO_RS22790	COG2894	cell division
WQO_RS22825	COG2197	response regulator
WQO_RS22845	COG2885	chlorophyll binding
WQO_RS22905	COG0667	Aldo Keto reductase
WQO_RS22910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WQO_RS22915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WQO_RS22930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WQO_RS22935	COG0450	alkyl hydroperoxide reductase
WQO_RS22950	COG1136	(ABC) transporter
WQO_RS22985	COG0114	fumarate hydratase activity
WQO_RS22995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS23010	COG1362	aminopeptidase activity
WQO_RS23035	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WQO_RS23035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WQO_RS23060	COG0778	Nitroreductase
WQO_RS23065	COG1722	exodeoxyribonuclease VII activity
WQO_RS23070	COG1570	exodeoxyribonuclease VII activity
WQO_RS23080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WQO_RS23095	COG0012	GTP binding
WQO_RS23175	COG1842	Phage shock protein A
WQO_RS23185	COG0463	Glycosyl transferase, family 2
WQO_RS23210	COG1309	transcriptional regulator
WQO_RS23230	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS23280	COG2770	Histidine kinase
WQO_RS23280	COG2208	phosphoserine phosphatase activity
WQO_RS23300	COG0702	epimerase
WQO_RS23305	COG3631	Ketosteroid isomerase-related protein
WQO_RS23345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WQO_RS23375	COG0395	ABC-type sugar transport system, permease component
WQO_RS23380	COG1175	transmembrane transport
WQO_RS23400	COG1609	Transcriptional regulator
WQO_RS23410	COG1217	gtp-binding protein TYPA
WQO_RS23415	COG4166	transmembrane transport
WQO_RS23420	COG0601	transmembrane transport
WQO_RS23425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WQO_RS23435	COG4608	Belongs to the ABC transporter superfamily
WQO_RS23440	COG4166	transmembrane transport
WQO_RS23445	COG0601	transmembrane transport
WQO_RS23450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WQO_RS23455	COG0444	Belongs to the ABC transporter superfamily
WQO_RS23460	COG4608	Belongs to the ABC transporter superfamily
WQO_RS23480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WQO_RS23505	COG0110	maltose O-acetyltransferase activity
WQO_RS23520	COG0515	serine threonine protein kinase
WQO_RS23530	COG1132	(ABC) transporter
WQO_RS23535	COG1132	(ABC) transporter
WQO_RS23540	COG2197	response regulator
WQO_RS23545	COG2912	Transglutaminase-like superfamily
WQO_RS23575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WQO_RS23580	COG1611	Belongs to the LOG family
WQO_RS23585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WQO_RS23595	COG0519	Catalyzes the synthesis of GMP from XMP
WQO_RS23600	COG1024	Enoyl-CoA hydratase
WQO_RS23610	COG1595	DNA-templated transcription, initiation
WQO_RS23620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WQO_RS23625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WQO_RS23660	COG0598	Magnesium transport protein CorA
WQO_RS23670	COG2814	Major facilitator Superfamily
WQO_RS23680	COG0613	PHP domain protein
WQO_RS23685	COG2095	MarC family integral membrane protein
WQO_RS23690	COG1432	Conserved Protein
WQO_RS23695	COG0596	Alpha beta hydrolase
WQO_RS23700	COG0513	Belongs to the DEAD box helicase family
WQO_RS23795	COG0210	DNA helicase
WQO_RS23840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WQO_RS23890	COG3480	Lon protease (S16) C-terminal proteolytic domain
WQO_RS23900	COG1615	UPF0182 protein
WQO_RS23925	COG0753	catalase activity
WQO_RS23935	COG0483	inositol monophosphate 1-phosphatase activity
WQO_RS23945	COG2076	Multidrug Resistance protein
WQO_RS23950	COG1162	GTPase activity
WQO_RS23955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WQO_RS23965	COG2135	peptidase activity
WQO_RS23975	COG1595	DNA-templated transcription, initiation
WQO_RS23980	COG5662	AntiSigma factor
WQO_RS24000	COG0242	peptide deformylase activity
WQO_RS24025	COG1131	(ABC) transporter
WQO_RS24055	COG1966	Carbon starvation protein
WQO_RS24065	COG2182	Extracellular solute-binding protein
WQO_RS24070	COG1175	transmembrane transport
WQO_RS24075	COG0395	ABC-type sugar transport system, permease component
WQO_RS24080	COG1472	Belongs to the glycosyl hydrolase 3 family
WQO_RS24085	COG0363	glucosamine-6-phosphate deaminase activity
WQO_RS24090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WQO_RS24105	COG1597	lipid kinase activity
WQO_RS24120	COG2172	sigma factor antagonist activity
WQO_RS24135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WQO_RS24140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WQO_RS24145	COG0142	geranyltranstransferase activity
WQO_RS24220	COG0789	Transcriptional regulator
WQO_RS24225	COG0659	secondary active sulfate transmembrane transporter activity
WQO_RS24250	COG4106	trans-aconitate 2-methyltransferase activity
WQO_RS24255	COG1126	abc transporter atp-binding protein
WQO_RS24260	COG0765	amino acid transport
WQO_RS24265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS24270	COG0281	malic enzyme
WQO_RS24275	COG0604	alcohol dehydrogenase
WQO_RS24295	COG0542	response to heat
WQO_RS24320	COG0508	dehydrogenase complex catalyzes the overall conversion of
WQO_RS24320	COG0567	Dehydrogenase, E1 component
WQO_RS24325	COG2205	protein histidine kinase activity
WQO_RS24330	COG0745	RESPONSE REGULATOR receiver
WQO_RS24340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WQO_RS24345	COG0726	polysaccharide deacetylase
WQO_RS24360	COG5002	protein histidine kinase activity
WQO_RS24385	COG3293	Transposase
WQO_RS24410	COG1309	transcriptional regulator
WQO_RS24435	COG0768	penicillin binding
WQO_RS24450	COG2205	protein histidine kinase activity
WQO_RS24470	COG3285	dna ligase
WQO_RS24470	COG1793	dna ligase
WQO_RS24475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
WQO_RS24490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WQO_RS24505	COG0454	-acetyltransferase
WQO_RS24510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WQO_RS24520	COG2890	protein-(glutamine-N5) methyltransferase activity
WQO_RS24535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS24545	COG0662	Cupin 2, conserved barrel domain protein
WQO_RS24550	COG1960	acyl-CoA dehydrogenase activity
WQO_RS24560	COG2313	pseudouridylate synthase activity
WQO_RS24565	COG0546	phosphoglycolate phosphatase activity
WQO_RS24590	COG0018	arginyl-trna synthetase
WQO_RS24595	COG0019	diaminopimelate decarboxylase activity
WQO_RS24600	COG0460	homoserine dehydrogenase
WQO_RS24605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WQO_RS24610	COG0083	homoserine kinase activity
WQO_RS24625	COG1316	TRANSCRIPTIONal
WQO_RS24630	COG0254	rRNA binding
WQO_RS24635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WQO_RS24640	COG2890	protein-(glutamine-N5) methyltransferase activity
WQO_RS24650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WQO_RS24655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WQO_RS24675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WQO_RS24680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WQO_RS24685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WQO_RS24690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WQO_RS24695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WQO_RS24700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WQO_RS24705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WQO_RS24720	COG2197	response regulator
WQO_RS24725	COG4585	Histidine kinase
WQO_RS24740	COG1250	3-hydroxyacyl-CoA dehydrogenase
WQO_RS24755	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
WQO_RS24790	COG1131	(ABC) transporter
WQO_RS24810	COG0183	Belongs to the thiolase family
WQO_RS24825	COG0745	RESPONSE REGULATOR receiver
WQO_RS24830	COG5002	protein histidine kinase activity
WQO_RS24830	COG5000	phosphorelay sensor kinase activity
WQO_RS24900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WQO_RS24900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WQO_RS24940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WQO_RS24945	COG0857	belongs to the CobB CobQ family
WQO_RS24945	COG0280	phosphate acetyltransferase
WQO_RS24950	COG0205	6-phosphofructokinase activity
WQO_RS24960	COG4565	transcriptional regulatory protein
WQO_RS24965	COG3290	protein histidine kinase activity
WQO_RS24970	COG1301	dicarboxylic acid transport
WQO_RS24985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WQO_RS24990	COG3281	Trehalose synthase
WQO_RS24995	COG0366	Alpha amylase catalytic
WQO_RS25000	COG0366	Alpha amylase catalytic
WQO_RS25005	COG0058	SHG alpha-glucan phosphorylase activity
WQO_RS25040	COG1132	(ABC) transporter
WQO_RS25045	COG1132	(ABC) transporter
WQO_RS25050	COG1131	(ABC) transporter
WQO_RS25065	COG2197	response regulator
WQO_RS25205	COG0823	Involved in the tonB-independent uptake of proteins
WQO_RS25205	COG1506	peptidase
WQO_RS25215	COG0464	growth
WQO_RS25220	COG2235	arginine
WQO_RS25235	COG0747	negative chemotaxis
WQO_RS25255	COG1760	l-serine dehydratase
WQO_RS25260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WQO_RS25265	COG0509	glycine decarboxylation via glycine cleavage system
WQO_RS25270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WQO_RS25290	COG0747	negative chemotaxis
WQO_RS25295	COG0601	transmembrane transport
WQO_RS25300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WQO_RS25310	COG4608	Belongs to the ABC transporter superfamily
WQO_RS25315	COG2860	membrane
WQO_RS25350	COG0482	sulfurtransferase activity
WQO_RS25370	COG4221	oxidoreductase activity
WQO_RS25380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WQO_RS25390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WQO_RS25395	COG0154	amidase activity
WQO_RS25405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WQO_RS25410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WQO_RS25420	COG2409	Drug exporters of the RND superfamily
WQO_RS25435	COG3293	Transposase
WQO_RS25445	COG2197	response regulator
WQO_RS25455	COG2133	pyrroloquinoline quinone binding
WQO_RS25460	COG0667	Aldo Keto reductase
WQO_RS25470	COG3300	MHYT domain
WQO_RS25470	COG5001	Diguanylate cyclase
WQO_RS25480	COG0440	acetolactate synthase activity
WQO_RS25485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WQO_RS25490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WQO_RS25510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WQO_RS25515	COG2508	Transcriptional regulator
WQO_RS25520	COG0506	proline dehydrogenase activity
WQO_RS25525	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS25540	COG0473	3-isopropylmalate dehydrogenase activity
WQO_RS25545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WQO_RS25550	COG2957	Belongs to the agmatine deiminase family
WQO_RS25560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WQO_RS25565	COG1609	Transcriptional regulator
WQO_RS25575	COG4608	Belongs to the ABC transporter superfamily
WQO_RS25580	COG0601	transmembrane transport
WQO_RS25585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WQO_RS25590	COG0444	Belongs to the ABC transporter superfamily
WQO_RS25600	COG1472	Belongs to the glycosyl hydrolase 3 family
WQO_RS25625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WQO_RS25645	COG2207	Transcriptional regulator
WQO_RS25645	COG3708	Transcriptional regulator
WQO_RS25665	COG0492	ferredoxin-NADP+ reductase activity
WQO_RS25705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS25710	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS25715	COG1120	ATPase activity
WQO_RS25720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WQO_RS25745	COG1470	cell adhesion involved in biofilm formation
WQO_RS25745	COG0366	Alpha amylase catalytic
WQO_RS25750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WQO_RS25775	COG2018	Roadblock/LC7 domain
WQO_RS25795	COG2018	Roadblock/LC7 domain
WQO_RS25800	COG5002	protein histidine kinase activity
WQO_RS25810	COG0179	Fumarylacetoacetate (FAA) hydrolase
WQO_RS25815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WQO_RS25850	COG1414	Transcriptional regulator
WQO_RS25855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WQO_RS25860	COG0066	3-isopropylmalate dehydratase activity
WQO_RS25870	COG0776	regulation of translation
WQO_RS25880	COG1920	GTP binding
WQO_RS25890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WQO_RS25895	COG1181	Belongs to the D-alanine--D-alanine ligase family
WQO_RS25915	COG0351	phosphomethylpyrimidine kinase
WQO_RS25920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WQO_RS25925	COG1461	Dihydroxyacetone kinase
WQO_RS25930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WQO_RS25935	COG0742	ribosomal rna small subunit methyltransferase
WQO_RS25940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WQO_RS25955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WQO_RS25960	COG0571	ribonuclease III activity
WQO_RS25965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WQO_RS25970	COG1733	regulation of RNA biosynthetic process
WQO_RS25985	COG2188	Transcriptional regulator
WQO_RS26010	COG2340	Cysteine-rich secretory protein family
WQO_RS26015	COG1254	Belongs to the acylphosphatase family
WQO_RS26025	COG1196	nuclear chromosome segregation
WQO_RS26030	COG0477	Major facilitator Superfamily
WQO_RS26065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WQO_RS26085	COG0228	four-way junction DNA binding
WQO_RS26090	COG1837	Belongs to the UPF0109 family
WQO_RS26095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WQO_RS26100	COG0336	Belongs to the RNA methyltransferase TrmD family
WQO_RS26105	COG0335	large ribosomal subunit rRNA binding
WQO_RS26115	COG0681	Belongs to the peptidase S26 family
WQO_RS26120	COG0681	Belongs to the peptidase S26 family
WQO_RS26140	COG0792	nuclease activity
WQO_RS26155	COG1191	sigma factor activity
WQO_RS26170	COG0052	Belongs to the universal ribosomal protein uS2 family
WQO_RS26175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WQO_RS26180	COG0528	UMP kinase activity
WQO_RS26185	COG0233	cytoplasmic translational termination
WQO_RS26190	COG0575	Belongs to the CDS family
WQO_RS26195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WQO_RS26210	COG3842	ATPase activity
WQO_RS26215	COG2197	response regulator
WQO_RS26220	COG4585	Histidine kinase
WQO_RS26250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WQO_RS26260	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS26280	COG2197	response regulator
WQO_RS26285	COG4585	Histidine kinase
WQO_RS26300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WQO_RS26320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WQO_RS26325	COG3842	ATPase activity
WQO_RS26330	COG1176	ABC-type spermidine putrescine transport system, permease component I
WQO_RS26335	COG1177	transmembrane transport
WQO_RS26340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WQO_RS26370	COG2508	Transcriptional regulator
WQO_RS26375	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS26385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WQO_RS26390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WQO_RS26395	COG0750	zinc metalloprotease
WQO_RS26400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WQO_RS26415	COG0442	prolyl-tRNA aminoacylation
WQO_RS26435	COG0779	Required for maturation of 30S ribosomal subunits
WQO_RS26450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WQO_RS26460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WQO_RS26465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WQO_RS26510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WQO_RS26515	COG0601	transmembrane transport
WQO_RS26520	COG0747	negative chemotaxis
WQO_RS26525	COG0455	bacterial-type flagellum organization
WQO_RS26545	COG3266	domain, Protein
WQO_RS26550	COG1404	Belongs to the peptidase S8 family
WQO_RS26575	COG4842	Belongs to the WXG100 family
WQO_RS26580	COG1674	ftsk spoiiie
WQO_RS26590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WQO_RS26595	COG1185	polyribonucleotide nucleotidyltransferase activity
WQO_RS26600	COG0612	Peptidase, M16
WQO_RS26605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WQO_RS26625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WQO_RS26630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WQO_RS26635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WQO_RS26660	COG2770	Histidine kinase
WQO_RS26660	COG2208	phosphoserine phosphatase activity
WQO_RS26665	COG3850	Histidine kinase
WQO_RS26665	COG4999	Histidine kinase
WQO_RS26665	COG3437	response regulator, receiver
WQO_RS26665	COG2205	protein histidine kinase activity
WQO_RS26675	COG1674	ftsk spoiiie
WQO_RS26685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WQO_RS26695	COG1546	Belongs to the CinA family
WQO_RS26695	COG1058	Belongs to the CinA family
WQO_RS26700	COG1396	sequence-specific DNA binding
WQO_RS26705	COG0783	Belongs to the Dps family
WQO_RS26715	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS26720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WQO_RS26725	COG1201	RNA secondary structure unwinding
WQO_RS26730	COG1917	Cupin 2, conserved barrel domain protein
WQO_RS26730	COG2207	Transcriptional regulator
WQO_RS26770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WQO_RS26800	COG0765	amino acid transport
WQO_RS26805	COG0765	amino acid transport
WQO_RS26810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS26815	COG1126	abc transporter atp-binding protein
WQO_RS26820	COG0745	RESPONSE REGULATOR receiver
WQO_RS26825	COG2205	protein histidine kinase activity
WQO_RS26835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WQO_RS26850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WQO_RS26860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WQO_RS26865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WQO_RS26875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WQO_RS26915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WQO_RS26920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WQO_RS26925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WQO_RS26945	COG0588	phosphoglycerate mutase activity
WQO_RS26960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WQO_RS26990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WQO_RS26995	COG1802	Transcriptional regulator
WQO_RS27000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WQO_RS27025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WQO_RS27030	COG4565	transcriptional regulatory protein
WQO_RS27035	COG3290	protein histidine kinase activity
WQO_RS27045	COG0372	Belongs to the citrate synthase family
WQO_RS27050	COG0372	Belongs to the citrate synthase family
WQO_RS27060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WQO_RS27065	COG0612	Peptidase, M16
WQO_RS27080	COG1802	Transcriptional regulator
WQO_RS27085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WQO_RS27090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WQO_RS27090	COG1042	CoA-binding domain protein
WQO_RS27090	COG0045	succinate-CoA ligase (ADP-forming) activity
WQO_RS27105	COG1435	thymidine kinase activity
WQO_RS27145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WQO_RS27155	COG0745	RESPONSE REGULATOR receiver
WQO_RS27160	COG2205	protein histidine kinase activity
WQO_RS27185	COG0756	dUTP diphosphatase activity
WQO_RS27195	COG1136	(ABC) transporter
WQO_RS27195	COG4591	ABC-type transport system involved in lipoprotein release permease component
WQO_RS27225	COG0569	domain protein
WQO_RS27230	COG0531	amino acid
WQO_RS27235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WQO_RS27260	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
WQO_RS27265	COG1121	(ABC) transporter
WQO_RS27270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WQO_RS27305	COG3850	Histidine kinase
WQO_RS27305	COG5002	protein histidine kinase activity
WQO_RS27310	COG2843	Capsule synthesis protein
WQO_RS27340	COG0446	pyridine nucleotide-disulphide oxidoreductase
WQO_RS27350	COG3938	Belongs to the proline racemase family
WQO_RS27355	COG1802	Transcriptional regulator
WQO_RS27360	COG3291	Pkd domain containing protein
WQO_RS27370	COG1280	lysine exporter protein (LysE YggA)
WQO_RS27375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WQO_RS27380	COG3046	protein related to deoxyribodipyrimidine photolyase
WQO_RS27400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS27405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS27420	COG0586	Pfam SNARE associated Golgi protein
WQO_RS27425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WQO_RS27430	COG1349	DNA-binding transcription factor activity
WQO_RS27435	COG1799	cell septum assembly
WQO_RS27455	COG2040	homocysteine
WQO_RS27465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WQO_RS27475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WQO_RS27480	COG0531	amino acid
WQO_RS27490	COG1024	Enoyl-CoA hydratase
WQO_RS27530	COG2111	Na H antiporter
WQO_RS27530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WQO_RS27535	COG1006	Multisubunit Na H antiporter MnhC subunit
WQO_RS27540	COG0651	ATP synthesis coupled electron transport
WQO_RS27570	COG0297	glycogen (starch) synthase activity
WQO_RS27575	COG0489	protein tyrosine kinase activity
WQO_RS27610	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
WQO_RS27615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WQO_RS27620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WQO_RS27635	COG2172	sigma factor antagonist activity
WQO_RS27635	COG2208	phosphoserine phosphatase activity
WQO_RS27635	COG1366	Belongs to the anti-sigma-factor antagonist family
WQO_RS27655	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS27660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WQO_RS27700	COG1132	(ABC) transporter
WQO_RS27710	COG2319	Wd-40 repeat
WQO_RS27720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WQO_RS27725	COG3548	integral membrane protein
WQO_RS27745	COG1742	UPF0060 membrane protein
WQO_RS27755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WQO_RS27765	COG0588	phosphoglycerate mutase activity
WQO_RS27775	COG1653	transport
WQO_RS27780	COG1175	transmembrane transport
WQO_RS27785	COG0395	ABC-type sugar transport system, permease component
WQO_RS27790	COG1940	carbohydrate kinase activity
WQO_RS27795	COG4213	ABC transporter substrate-binding protein
WQO_RS27805	COG4214	carbohydrate transport
WQO_RS27810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WQO_RS27815	COG0531	amino acid
WQO_RS27830	COG1316	TRANSCRIPTIONal
WQO_RS27835	COG1024	Enoyl-CoA hydratase
WQO_RS27835	COG1250	3-hydroxyacyl-CoA dehydrogenase
WQO_RS27840	COG0183	Belongs to the thiolase family
WQO_RS27865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WQO_RS27870	COG0446	pyridine nucleotide-disulphide oxidoreductase
WQO_RS27880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WQO_RS27885	COG3253	May function as heme-dependent peroxidase
WQO_RS27900	COG3220	belongs to the UPF0276 family
WQO_RS27955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WQO_RS27960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WQO_RS27990	COG1653	transport
WQO_RS28065	COG1063	alcohol dehydrogenase
WQO_RS28070	COG0156	8-amino-7-oxononanoate synthase activity
WQO_RS28075	COG0583	DNA-binding transcription factor activity
WQO_RS28090	COG0346	lactoylglutathione lyase activity
WQO_RS28110	COG2723	6-phospho-beta-galactosidase activity
WQO_RS28170	COG1175	transmembrane transport
WQO_RS28190	COG1404	Belongs to the peptidase S8 family
WQO_RS28210	COG1132	(ABC) transporter
WQO_RS28215	COG1132	(ABC) transporter
WQO_RS28220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
WQO_RS28225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS28230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS28235	COG1120	ATPase activity
WQO_RS28240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WQO_RS28245	COG2226	methyltransferase
WQO_RS28255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WQO_RS28260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WQO_RS28285	COG0529	Catalyzes the synthesis of activated sulfate
WQO_RS28290	COG0175	sulfate reduction
WQO_RS28315	COG1191	sigma factor activity
WQO_RS28330	COG1960	acyl-CoA dehydrogenase activity
WQO_RS28350	COG1250	3-hydroxyacyl-CoA dehydrogenase
WQO_RS28355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WQO_RS28360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WQO_RS28365	COG0583	DNA-binding transcription factor activity
WQO_RS28370	COG0183	Belongs to the thiolase family
WQO_RS28420	COG1162	GTPase activity
WQO_RS28450	COG0028	Belongs to the TPP enzyme family
WQO_RS28480	COG1802	Transcriptional regulator
WQO_RS28505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WQO_RS28510	COG2252	PERMEase
WQO_RS28515	COG3608	succinylglutamate desuccinylase aspartoacylase
WQO_RS28515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WQO_RS28555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS28585	COG0435	Glutathione S-transferase
WQO_RS28600	COG2197	response regulator
WQO_RS28605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WQO_RS28610	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS28630	COG3960	tartronate-semialdehyde synthase activity
WQO_RS28645	COG0753	catalase activity
WQO_RS28650	COG2084	Dehydrogenase
WQO_RS28655	COG3622	Belongs to the hyi family
WQO_RS28660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
WQO_RS28665	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WQO_RS28670	COG0395	ABC-type sugar transport system, permease component
WQO_RS28675	COG1175	transmembrane transport
WQO_RS28685	COG2188	Transcriptional regulator
WQO_RS28690	COG2706	6-phosphogluconolactonase activity
WQO_RS28710	COG2351	hydroxyisourate hydrolase activity
WQO_RS28720	COG2233	PERMEase
WQO_RS28730	COG2233	PERMEase
WQO_RS28755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WQO_RS28760	COG0746	molybdenum cofactor guanylyltransferase activity
WQO_RS28770	COG2197	response regulator
WQO_RS28785	COG1136	(ABC) transporter
WQO_RS28785	COG0577	efflux transmembrane transporter activity
WQO_RS28790	COG1414	Transcriptional regulator
WQO_RS28795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WQO_RS28800	COG4266	Belongs to the allantoicase family
WQO_RS28805	COG0656	L-ascorbic acid biosynthetic process
WQO_RS28810	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS28835	COG2197	response regulator
WQO_RS28850	COG0673	inositol 2-dehydrogenase activity
WQO_RS28855	COG2188	Transcriptional regulator
WQO_RS28860	COG1879	ABC-type sugar transport system periplasmic component
WQO_RS28870	COG1129	ABC transporter
WQO_RS28875	COG1940	carbohydrate kinase activity
WQO_RS28930	COG2072	flavoprotein involved in K transport
WQO_RS28935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WQO_RS28945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WQO_RS28955	COG3629	intracellular signal transduction
WQO_RS28960	COG0156	8-amino-7-oxononanoate synthase activity
WQO_RS28985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WQO_RS28995	COG0662	Cupin 2, conserved barrel domain protein
WQO_RS29000	COG1960	acyl-CoA dehydrogenase activity
WQO_RS29010	COG0134	indole-3-glycerol-phosphate synthase activity
WQO_RS29025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WQO_RS29030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WQO_RS29045	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS29055	COG1126	abc transporter atp-binding protein
WQO_RS29060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WQO_RS29065	COG0765	amino acid transport
WQO_RS29070	COG0765	amino acid transport
WQO_RS29090	COG0405	Gamma-glutamyltransferase
WQO_RS29125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WQO_RS29130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WQO_RS29140	COG1953	Uracil, thiamine, allantoin
WQO_RS29160	COG1191	sigma factor activity
WQO_RS29165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WQO_RS29170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WQO_RS29180	COG2205	protein histidine kinase activity
WQO_RS29205	COG0095	Lipoate-protein ligase
WQO_RS29220	COG1024	Enoyl-CoA hydratase
WQO_RS29250	COG0477	Major facilitator Superfamily
WQO_RS29255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WQO_RS29275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WQO_RS29305	COG2233	PERMEase
WQO_RS29380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WQO_RS29415	COG2072	flavoprotein involved in K transport
WQO_RS29420	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS29440	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS29475	COG1929	Belongs to the glycerate kinase type-1 family
WQO_RS29495	COG0559	Belongs to the binding-protein-dependent transport system permease family
WQO_RS29525	COG0688	phosphatidylethanolamine metabolic process
WQO_RS29530	COG1960	acyl-CoA dehydrogenase activity
WQO_RS29540	COG2301	Belongs to the HpcH HpaI aldolase family
WQO_RS29545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WQO_RS29545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WQO_RS29550	COG0604	alcohol dehydrogenase
WQO_RS29565	COG1250	3-hydroxyacyl-CoA dehydrogenase
WQO_RS29580	COG0596	Alpha beta hydrolase
WQO_RS29605	COG0583	DNA-binding transcription factor activity
WQO_RS29610	COG0667	Aldo Keto reductase
WQO_RS29630	COG2362	D-Aminopeptidase
WQO_RS29635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WQO_RS29645	COG1619	proteins homologs of microcin C7 resistance protein MccF
WQO_RS29665	COG0457	Tetratricopeptide repeat
WQO_RS29720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WQO_RS29735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WQO_RS29735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WQO_RS29745	COG2154	pterin-4-alpha-carbinolamine dehydratase
WQO_RS29760	COG4106	trans-aconitate 2-methyltransferase activity
WQO_RS29770	COG0656	L-ascorbic acid biosynthetic process
WQO_RS29780	COG0583	DNA-binding transcription factor activity
WQO_RS29795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WQO_RS29800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WQO_RS29810	COG1129	ABC transporter
WQO_RS29815	COG1172	Belongs to the binding-protein-dependent transport system permease family
WQO_RS29820	COG1879	ABC-type sugar transport system periplasmic component
WQO_RS29825	COG0673	inositol 2-dehydrogenase activity
WQO_RS29845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WQO_RS29940	COG3321	synthase
WQO_RS29940	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS29940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS29940	COG0318	PFAM AMP-dependent synthetase and ligase
WQO_RS29940	COG0300	oxidoreductase activity
WQO_RS29945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WQO_RS29955	COG2124	cytochrome p450
WQO_RS29960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WQO_RS29965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS29970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS29990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS30000	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS30025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WQO_RS30030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WQO_RS30035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WQO_RS30040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WQO_RS30045	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS30065	COG0477	Major facilitator Superfamily
WQO_RS30070	COG1960	acyl-CoA dehydrogenase activity
WQO_RS30080	COG1129	ABC transporter
WQO_RS30090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WQO_RS30095	COG1869	D-ribose catabolic process
WQO_RS30105	COG2205	protein histidine kinase activity
WQO_RS30110	COG0745	RESPONSE REGULATOR receiver
WQO_RS30115	COG0728	peptidoglycan biosynthetic process
WQO_RS30125	COG1376	ErfK ybiS ycfS ynhG family protein
WQO_RS30135	COG0714	Associated with various cellular activities
WQO_RS30150	COG3568	Endonuclease Exonuclease Phosphatase
WQO_RS30165	COG5002	protein histidine kinase activity
WQO_RS30190	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS30200	COG0517	IMP dehydrogenase activity
WQO_RS30200	COG4175	Glycine betaine
WQO_RS30205	COG4176	ABC-type proline glycine betaine transport system permease component
WQO_RS30215	COG2124	cytochrome p450
WQO_RS30245	COG1070	Carbohydrate kinase
WQO_RS30255	COG1940	carbohydrate kinase activity
WQO_RS30280	COG1846	Transcriptional regulator
WQO_RS30305	COG2124	cytochrome p450
WQO_RS30310	COG1486	melibiose metabolic process
WQO_RS30340	COG3012	SEC-C Motif Domain Protein
WQO_RS30360	COG1960	acyl-CoA dehydrogenase activity
WQO_RS30405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WQO_RS30430	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WQO_RS30470	COG2326	polyphosphate kinase activity
WQO_RS30475	COG1793	dna ligase
WQO_RS30530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WQO_RS30540	COG0488	(ABC) transporter
WQO_RS30570	COG1515	deoxyribonuclease V activity
WQO_RS30580	COG3268	Saccharopine dehydrogenase
WQO_RS30585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WQO_RS30590	COG1960	acyl-CoA dehydrogenase activity
WQO_RS30595	COG0183	Belongs to the thiolase family
WQO_RS30600	COG1024	Enoyl-CoA hydratase
WQO_RS30600	COG1250	3-hydroxyacyl-CoA dehydrogenase
WQO_RS30605	COG0789	Transcriptional regulator
WQO_RS30630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WQO_RS30650	COG0488	(ABC) transporter
WQO_RS30670	COG4977	sequence-specific DNA binding
WQO_RS30680	COG1024	Enoyl-CoA hydratase
WQO_RS30695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WQO_RS30725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WQO_RS30745	COG1388	LysM domain
WQO_RS30745	COG1134	teichoic acid transport
WQO_RS30750	COG1562	ergosterol biosynthetic process
WQO_RS30760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WQO_RS30770	COG1657	PFAM Prenyltransferase squalene oxidase
WQO_RS30805	COG2755	lipolytic protein G-D-S-L family
WQO_RS30855	COG3467	pyridoxamine 5'-phosphate
WQO_RS30865	COG0789	Transcriptional regulator
WQO_RS30920	COG1609	Transcriptional regulator
WQO_RS30925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WQO_RS30935	COG1116	anion transmembrane transporter activity
WQO_RS30955	COG3507	Belongs to the glycosyl hydrolase 43 family
WQO_RS30965	COG3958	Transketolase
WQO_RS30970	COG3959	Transketolase, thiamine diphosphate binding domain
WQO_RS30995	COG3511	phospholipase C
WQO_RS31005	COG2197	response regulator
WQO_RS31010	COG3851	Histidine kinase
WQO_RS31020	COG2186	Transcriptional regulator
WQO_RS31025	COG0247	lactate metabolic process
WQO_RS31030	COG1139	Iron-sulfur cluster binding protein
WQO_RS31035	COG1556	Lactate utilization protein
WQO_RS31065	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS31070	COG1309	transcriptional regulator
WQO_RS31075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WQO_RS31085	COG1953	Uracil, thiamine, allantoin
WQO_RS31100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WQO_RS31135	COG0446	pyridine nucleotide-disulphide oxidoreductase
WQO_RS31135	COG1902	pentaerythritol trinitrate reductase activity
WQO_RS31150	COG2409	Drug exporters of the RND superfamily
WQO_RS31155	COG1846	Transcriptional regulator
WQO_RS31200	COG1233	COG1233 Phytoene dehydrogenase and related
WQO_RS31205	COG2130	NADP-dependent
WQO_RS31215	COG4948	Mandelate Racemase Muconate Lactonizing
WQO_RS31220	COG0395	ABC-type sugar transport system, permease component
WQO_RS31225	COG1175	transmembrane transport
WQO_RS31235	COG2188	Transcriptional regulator
WQO_RS31290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WQO_RS31300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WQO_RS31305	COG0019	diaminopimelate decarboxylase activity
WQO_RS31320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WQO_RS31340	COG1119	ATPase activity
WQO_RS31350	COG1595	DNA-templated transcription, initiation
WQO_RS31360	COG3293	Transposase
WQO_RS31365	COG3415	Transposase
WQO_RS31365	COG2801	Transposase and inactivated derivatives
WQO_RS31395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WQO_RS31405	COG0395	ABC-type sugar transport system, permease component
WQO_RS31410	COG1175	transmembrane transport
WQO_RS31420	COG1940	carbohydrate kinase activity
WQO_RS31435	COG1652	LysM domain
WQO_RS31460	COG2208	phosphoserine phosphatase activity
WQO_RS31480	COG0784	Response regulator, receiver
WQO_RS31485	COG4251	negative regulation of phosphorylation
WQO_RS31490	COG4566	intracellular signal transduction
WQO_RS31495	COG1191	sigma factor activity
WQO_RS31535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WQO_RS31555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WQO_RS31560	COG3275	phosphorelay sensor kinase activity
WQO_RS31630	COG0583	DNA-binding transcription factor activity
WQO_RS31640	COG1053	succinate dehydrogenase
WQO_RS31645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WQO_RS31660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS31670	COG3360	Dodecin
WQO_RS31675	COG2182	Extracellular solute-binding protein
WQO_RS31690	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WQO_RS31695	COG0121	glutamine amidotransferase
WQO_RS31700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WQO_RS31720	COG1609	Transcriptional regulator
WQO_RS31730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WQO_RS31735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WQO_RS31750	COG0297	glycogen (starch) synthase activity
WQO_RS31755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WQO_RS31760	COG0477	Major facilitator Superfamily
WQO_RS31785	COG0714	Associated with various cellular activities
WQO_RS31790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
WQO_RS31805	COG1357	PFAM Pentapeptide repeats (8 copies)
WQO_RS31815	COG2045	Belongs to the ComB family
WQO_RS31825	COG3629	intracellular signal transduction
WQO_RS31825	COG3903	Transcriptional regulator
WQO_RS31830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WQO_RS31835	COG1834	amidinotransferase
WQO_RS31845	COG1228	amidohydrolase
WQO_RS31870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WQO_RS31895	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS31945	COG1024	Enoyl-CoA hydratase
WQO_RS31950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WQO_RS31980	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS31985	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS32020	COG1609	Transcriptional regulator
WQO_RS32035	COG1172	Belongs to the binding-protein-dependent transport system permease family
WQO_RS32040	COG1129	ABC transporter
WQO_RS32045	COG4952	isomerase
WQO_RS32050	COG3347	Dehydrogenase
WQO_RS32050	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS32055	COG1070	Carbohydrate kinase
WQO_RS32060	COG3250	beta-galactosidase activity
WQO_RS32075	COG1120	ATPase activity
WQO_RS32085	COG0477	Major facilitator Superfamily
WQO_RS32090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WQO_RS32100	COG0254	rRNA binding
WQO_RS32105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WQO_RS32110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WQO_RS32115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WQO_RS32130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS32135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS32140	COG1120	ATPase activity
WQO_RS32170	COG1132	(ABC) transporter
WQO_RS32195	COG2304	oxidoreductase activity
WQO_RS32215	COG0438	transferase activity, transferring glycosyl groups
WQO_RS32220	COG0726	polysaccharide deacetylase
WQO_RS32240	COG0297	glycogen (starch) synthase activity
WQO_RS32240	COG0438	transferase activity, transferring glycosyl groups
WQO_RS32280	COG0656	L-ascorbic acid biosynthetic process
WQO_RS32290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WQO_RS32310	COG1960	acyl-CoA dehydrogenase activity
WQO_RS32315	COG1960	acyl-CoA dehydrogenase activity
WQO_RS32320	COG2188	Transcriptional regulator
WQO_RS32335	COG1175	transmembrane transport
WQO_RS32340	COG0395	ABC-type sugar transport system, permease component
WQO_RS32350	COG0601	transmembrane transport
WQO_RS32355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WQO_RS32360	COG0444	Belongs to the ABC transporter superfamily
WQO_RS32365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WQO_RS32445	COG1796	DNA polymerase
WQO_RS32445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WQO_RS32550	COG1278	Cold shock
WQO_RS32565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
WQO_RS32570	COG0693	protein deglycase activity
WQO_RS32580	COG2375	cellular response to nickel ion
WQO_RS32590	COG4044	May play a role in the intracellular transport of hydrophobic ligands
WQO_RS32610	COG1063	alcohol dehydrogenase
WQO_RS32645	COG0789	Transcriptional regulator
WQO_RS32650	COG1960	acyl-CoA dehydrogenase activity
WQO_RS32660	COG1408	metallophosphoesterase
WQO_RS32675	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WQO_RS32675	COG1672	PFAM Archaeal ATPase
WQO_RS32695	COG1794	racemase activity, acting on amino acids and derivatives
WQO_RS32720	COG0326	Molecular chaperone. Has ATPase activity
WQO_RS32750	COG0542	response to heat
WQO_RS32760	COG0484	heat shock protein binding
WQO_RS32765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WQO_RS32770	COG0443	Heat shock 70 kDa protein
WQO_RS32785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WQO_RS32810	COG0693	protein deglycase activity
WQO_RS32830	COG1012	belongs to the aldehyde dehydrogenase family
WQO_RS32850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WQO_RS32855	COG3239	Fatty acid desaturase
WQO_RS32885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WQO_RS32890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WQO_RS32895	COG0640	Transcriptional regulator
WQO_RS32910	COG2018	Roadblock/LC7 domain
WQO_RS32940	COG1024	Enoyl-CoA hydratase
WQO_RS32960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WQO_RS32965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WQO_RS32980	COG2340	Cysteine-rich secretory protein family
WQO_RS33015	COG0583	DNA-binding transcription factor activity
WQO_RS33035	COG0488	(ABC) transporter
WQO_RS33055	COG0009	L-threonylcarbamoyladenylate synthase
WQO_RS33095	COG2318	DinB family
WQO_RS33125	COG0395	ABC-type sugar transport system, permease component
WQO_RS33130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WQO_RS33135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WQO_RS33145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WQO_RS33150	COG1028	Short-chain dehydrogenase reductase Sdr
WQO_RS33160	COG0714	Associated with various cellular activities
WQO_RS33165	COG3552	Protein containing von Willebrand factor type A (VWA) domain
WQO_RS33195	COG2205	protein histidine kinase activity
WQO_RS33200	COG0745	RESPONSE REGULATOR receiver
WQO_RS33215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WQO_RS33220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WQO_RS33230	COG0656	L-ascorbic acid biosynthetic process
WQO_RS33235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WQO_RS33280	COG0586	Pfam SNARE associated Golgi protein
WQO_RS33290	COG2226	methyltransferase
WQO_RS33295	COG2226	methyltransferase
WQO_RS33315	COG1874	Beta-galactosidase
WQO_RS33320	COG1609	Transcriptional regulator
WQO_RS33325	COG0395	ABC-type sugar transport system, permease component
WQO_RS33330	COG1175	transmembrane transport
WQO_RS33335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WQO_RS33350	COG1595	DNA-templated transcription, initiation
WQO_RS33365	COG4214	carbohydrate transport
WQO_RS33375	COG4213	ABC transporter substrate-binding protein
WQO_RS33385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WQO_RS33400	COG1070	Carbohydrate kinase
WQO_RS33415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WQO_RS33430	COG0069	glutamate synthase activity
WQO_RS33465	COG2267	carboxylic ester hydrolase activity
WQO_RS33490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WQO_RS33500	COG2066	Belongs to the glutaminase family
WQO_RS33520	COG3293	Transposase
WQO_RS33580	COG3335	DDE superfamily endonuclease
WQO_RS33600	COG3335	DDE superfamily endonuclease