locus-tag	class	description
C0216_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0216_RS00015	COG0592	DNA-directed DNA polymerase activity
C0216_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C0216_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0216_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C0216_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0216_RS00065	COG0515	serine threonine protein kinase
C0216_RS00100	COG0705	Rhomboid family
C0216_RS00100	COG0457	Tetratricopeptide repeat
C0216_RS00120	COG3764	Sortase (surface protein transpeptidase)
C0216_RS00125	COG3764	Sortase (surface protein transpeptidase)
C0216_RS00130	COG0515	serine threonine protein kinase
C0216_RS00140	COG0768	penicillin binding
C0216_RS00155	COG1716	ATPase activity
C0216_RS00160	COG1716	ATPase activity
C0216_RS00170	COG4585	Histidine kinase
C0216_RS00195	COG1960	acyl-CoA dehydrogenase activity
C0216_RS00200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0216_RS00205	COG2151	metal-sulfur cluster biosynthetic enzyme
C0216_RS00210	COG3396	Phenylacetate-CoA oxygenase
C0216_RS00215	COG3460	Phenylacetate-CoA oxygenase
C0216_RS00220	COG3396	Phenylacetate-CoA oxygenase
C0216_RS00245	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0216_RS00250	COG1309	transcriptional regulator
C0216_RS00260	COG1522	sequence-specific DNA binding
C0216_RS00285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0216_RS00310	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0216_RS00310	COG1136	(ABC) transporter
C0216_RS00325	COG0515	serine threonine protein kinase
C0216_RS00330	COG0515	serine threonine protein kinase
C0216_RS00345	COG0022	dehydrogenase e1 component
C0216_RS00350	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0216_RS00400	COG2264	protein methyltransferase activity
C0216_RS00410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0216_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS00450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0216_RS00465	COG0667	Aldo Keto reductase
C0216_RS00500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C0216_RS00525	COG2146	nitrite reductase [NAD(P)H] activity
C0216_RS00525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0216_RS00530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0216_RS00535	COG0243	molybdopterin cofactor binding
C0216_RS00540	COG2223	nitrite transmembrane transporter activity
C0216_RS00545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0216_RS00575	COG1741	Belongs to the pirin family
C0216_RS00585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0216_RS00620	COG2271	Major facilitator Superfamily
C0216_RS00650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0216_RS00665	COG1362	aminopeptidase activity
C0216_RS00675	COG1960	acyl-CoA dehydrogenase activity
C0216_RS00735	COG1136	(ABC) transporter
C0216_RS00735	COG0577	efflux transmembrane transporter activity
C0216_RS00740	COG1136	(ABC) transporter
C0216_RS00770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0216_RS00775	COG2304	oxidoreductase activity
C0216_RS00785	COG2205	protein histidine kinase activity
C0216_RS00795	COG1289	transmembrane transporter activity
C0216_RS00805	COG1959	2 iron, 2 sulfur cluster binding
C0216_RS00885	COG0626	cystathionine gamma-synthase activity
C0216_RS00890	COG0662	Cupin 2, conserved barrel domain protein
C0216_RS00935	COG0513	Belongs to the DEAD box helicase family
C0216_RS00940	COG1278	Cold shock
C0216_RS00975	COG0596	Alpha beta hydrolase
C0216_RS00980	COG3226	Transcriptional regulator
C0216_RS01050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0216_RS01105	COG0717	Belongs to the dCTP deaminase family
C0216_RS01125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0216_RS01130	COG0443	Heat shock 70 kDa protein
C0216_RS01135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0216_RS01140	COG0484	heat shock protein binding
C0216_RS01145	COG0789	Transcriptional regulator
C0216_RS01170	COG0542	response to heat
C0216_RS01205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0216_RS01220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0216_RS01225	COG0191	fructose-bisphosphate aldolase activity
C0216_RS01245	COG3844	kynureninase activity
C0216_RS01255	COG0655	NAD(P)H dehydrogenase (quinone) activity
C0216_RS01260	COG1309	transcriptional regulator
C0216_RS01270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0216_RS01285	COG2124	cytochrome p450
C0216_RS01290	COG2197	response regulator
C0216_RS01300	COG2197	response regulator
C0216_RS01305	COG4585	Histidine kinase
C0216_RS01330	COG0693	protein deglycase activity
C0216_RS01335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0216_RS01340	COG1802	Transcriptional regulator
C0216_RS01365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0216_RS01370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0216_RS01390	COG1595	DNA-templated transcription, initiation
C0216_RS01410	COG0402	S-adenosylhomocysteine deaminase activity
C0216_RS01445	COG1408	metallophosphoesterase
C0216_RS01455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0216_RS01470	COG0003	Pfam Anion-transporting ATPase
C0216_RS01495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0216_RS01530	COG2267	carboxylic ester hydrolase activity
C0216_RS01540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0216_RS01545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0216_RS01610	COG1205	dead DEAH box helicase
C0216_RS01610	COG1111	helicase
C0216_RS01615	COG1366	Belongs to the anti-sigma-factor antagonist family
C0216_RS01620	COG2172	sigma factor antagonist activity
C0216_RS01625	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C0216_RS01635	COG2890	protein-(glutamine-N5) methyltransferase activity
C0216_RS01645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0216_RS01645	COG1754	DNA topoisomerase type I activity
C0216_RS01650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0216_RS01655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C0216_RS01675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0216_RS01675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0216_RS01700	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS01705	COG0768	penicillin binding
C0216_RS01710	COG2318	DinB family
C0216_RS01715	COG0789	Transcriptional regulator
C0216_RS01720	COG0586	Pfam SNARE associated Golgi protein
C0216_RS01730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0216_RS01735	COG2027	D-alanyl-D-alanine carboxypeptidase
C0216_RS01745	COG0037	tRNA processing
C0216_RS01750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C0216_RS01760	COG0302	gtp cyclohydrolase
C0216_RS01770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0216_RS01775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0216_RS01790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0216_RS01790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0216_RS01805	COG1174	glycine betaine transport
C0216_RS01810	COG1174	glycine betaine transport
C0216_RS01815	COG1732	Glycine betaine
C0216_RS01835	COG0649	NAD binding
C0216_RS01850	COG2197	response regulator
C0216_RS01865	COG2234	aminopeptidase activity
C0216_RS01880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C0216_RS01890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0216_RS01895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0216_RS01925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C0216_RS01950	COG0739	heme binding
C0216_RS01960	COG2205	protein histidine kinase activity
C0216_RS01965	COG0745	RESPONSE REGULATOR receiver
C0216_RS01975	COG1595	DNA-templated transcription, initiation
C0216_RS01980	COG1194	a g-specific adenine glycosylase
C0216_RS01985	COG0671	phosphoesterase, PA-phosphatase related
C0216_RS01995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C0216_RS02020	COG0248	Ppx GppA phosphatase
C0216_RS02025	COG1082	Xylose isomerase domain protein TIM barrel
C0216_RS02030	COG0129	dihydroxy-acid dehydratase activity
C0216_RS02045	COG4991	sh3 domain protein
C0216_RS02055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0216_RS02060	COG0180	Tryptophanyl-tRNA synthetase
C0216_RS02085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0216_RS02095	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0216_RS02145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C0216_RS02150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0216_RS02155	COG0181	hydroxymethylbilane synthase activity
C0216_RS02160	COG1648	precorrin-2 dehydrogenase activity
C0216_RS02160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0216_RS02165	COG0113	porphobilinogen synthase activity
C0216_RS02195	COG2161	toxin-antitoxin pair type II binding
C0216_RS02200	COG4115	mRNA cleavage
C0216_RS02215	COG2249	NAD(P)H dehydrogenase (quinone) activity
C0216_RS02220	COG0018	arginyl-trna synthetase
C0216_RS02225	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C0216_RS02245	COG1690	Belongs to the RtcB family
C0216_RS02270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0216_RS02275	COG0406	alpha-ribazole phosphatase activity
C0216_RS02280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0216_RS02285	COG0785	Cytochrome C biogenesis protein
C0216_RS02290	COG1333	cytochrome c biogenesis protein
C0216_RS02295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0216_RS02310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C0216_RS02335	COG0163	prenyltransferase activity
C0216_RS02345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C0216_RS02420	COG1278	Cold shock
C0216_RS02425	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C0216_RS02435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C0216_RS02455	COG2226	methyltransferase
C0216_RS02460	COG2066	Belongs to the glutaminase family
C0216_RS02485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02495	COG0649	NAD binding
C0216_RS02505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C0216_RS02510	COG1034	ATP synthesis coupled electron transport
C0216_RS02515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0216_RS02520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02525	COG0839	Belongs to the complex I subunit 6 family
C0216_RS02530	COG0713	ATP synthesis coupled electron transport
C0216_RS02535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0216_RS02545	COG1007	ATP synthesis coupled electron transport
C0216_RS02560	COG0561	phosphatase activity
C0216_RS02565	COG2936	dipeptidyl-peptidase activity
C0216_RS02570	COG0142	geranyltranstransferase activity
C0216_RS02615	COG0702	epimerase
C0216_RS02620	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0216_RS02625	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0216_RS02625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0216_RS02645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0216_RS02665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0216_RS02670	COG0839	Belongs to the complex I subunit 6 family
C0216_RS02675	COG0713	ATP synthesis coupled electron transport
C0216_RS02680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0216_RS02690	COG1007	ATP synthesis coupled electron transport
C0216_RS02695	COG0501	Belongs to the peptidase M48B family
C0216_RS02700	COG3304	Inner membrane component domain
C0216_RS02705	COG0463	Glycosyl transferase, family 2
C0216_RS02710	COG1666	GTP binding
C0216_RS02730	COG0702	epimerase
C0216_RS02735	COG0402	S-adenosylhomocysteine deaminase activity
C0216_RS02750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0216_RS02755	COG2030	dehydratase
C0216_RS02765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0216_RS02775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0216_RS02780	COG0436	Aminotransferase
C0216_RS02790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0216_RS02800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0216_RS02815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0216_RS02820	COG0222	ribosome binding
C0216_RS02830	COG0085	RNA polymerase activity
C0216_RS02835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0216_RS02845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0216_RS02850	COG0049	tRNA binding
C0216_RS02855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0216_RS02860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0216_RS02890	COG1215	transferase activity, transferring glycosyl groups
C0216_RS02915	COG0051	transcription antitermination factor activity, RNA binding
C0216_RS02920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0216_RS02925	COG0088	Forms part of the polypeptide exit tunnel
C0216_RS02930	COG0089	rRNA binding
C0216_RS02935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0216_RS02940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0216_RS02945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0216_RS02950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0216_RS02955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0216_RS02960	COG0255	Belongs to the universal ribosomal protein uL29 family
C0216_RS02965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0216_RS02970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0216_RS02975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0216_RS02980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0216_RS02985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0216_RS02995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0216_RS03000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0216_RS03005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0216_RS03010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0216_RS03015	COG1841	ribosomal large subunit assembly
C0216_RS03020	COG0200	Binds to the 23S rRNA
C0216_RS03025	COG0201	protein transport
C0216_RS03030	COG0563	adenylate kinase activity
C0216_RS03040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0216_RS03045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0216_RS03050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0216_RS03055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0216_RS03060	COG0202	RNA polymerase activity
C0216_RS03065	COG0203	ribosomal protein L17
C0216_RS03070	COG0101	tRNA pseudouridine synthase activity
C0216_RS03075	COG0488	(ABC) transporter
C0216_RS03085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0216_RS03090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0216_RS03095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0216_RS03100	COG1072	(Pantothenic acid kinase))
C0216_RS03110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0216_RS03115	COG0736	holo-[acyl-carrier-protein] synthase activity
C0216_RS03125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0216_RS03135	COG0802	atpase or kinase
C0216_RS03150	COG0456	acetyltransferase
C0216_RS03150	COG1214	PFAM Peptidase M22, glycoprotease
C0216_RS03160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0216_RS03175	COG0726	polysaccharide deacetylase
C0216_RS03180	COG0726	polysaccharide deacetylase
C0216_RS03190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0216_RS03205	COG4221	oxidoreductase activity
C0216_RS03215	COG0583	DNA-binding transcription factor activity
C0216_RS03225	COG2197	response regulator
C0216_RS03230	COG1595	DNA-templated transcription, initiation
C0216_RS03240	COG0516	GMP reductase activity
C0216_RS03250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0216_RS03255	COG0515	serine threonine protein kinase
C0216_RS03265	COG0515	serine threonine protein kinase
C0216_RS03270	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS03285	COG0519	Catalyzes the synthesis of GMP from XMP
C0216_RS03285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0216_RS03320	COG2197	response regulator
C0216_RS03355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS03355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS03370	COG0714	Associated with various cellular activities
C0216_RS03380	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C0216_RS03385	COG0045	succinate-CoA ligase (ADP-forming) activity
C0216_RS03415	COG0138	bifunctional purine biosynthesis protein purh
C0216_RS03425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0216_RS03435	COG0039	L-malate dehydrogenase activity
C0216_RS03440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0216_RS03445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0216_RS03465	COG0754	glutathionylspermidine amidase activity
C0216_RS03470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0216_RS03475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0216_RS03480	COG0180	Tryptophanyl-tRNA synthetase
C0216_RS03490	COG1295	ribonuclease BN
C0216_RS03505	COG1408	metallophosphoesterase
C0216_RS03515	COG0604	alcohol dehydrogenase
C0216_RS03520	COG1309	transcriptional regulator
C0216_RS03535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0216_RS03545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0216_RS03550	COG1053	succinate dehydrogenase
C0216_RS03560	COG2009	succinate dehydrogenase
C0216_RS03570	COG1595	DNA-templated transcription, initiation
C0216_RS03585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS03585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS03595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C0216_RS03595	COG1473	amidohydrolase
C0216_RS03600	COG1744	ABC transporter substrate-binding protein PnrA-like
C0216_RS03605	COG3845	ABC transporter
C0216_RS03610	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0216_RS03615	COG1079	Belongs to the binding-protein-dependent transport system permease family
C0216_RS03640	COG2814	Major facilitator Superfamily
C0216_RS03645	COG0583	DNA-binding transcription factor activity
C0216_RS03665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0216_RS03715	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS03720	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS03735	COG1595	DNA-templated transcription, initiation
C0216_RS03740	COG0745	RESPONSE REGULATOR receiver
C0216_RS03745	COG2205	protein histidine kinase activity
C0216_RS03765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0216_RS03810	COG4770	biotin carboxylase activity
C0216_RS03830	COG0424	maF-like protein
C0216_RS03840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0216_RS03855	COG1024	Enoyl-CoA hydratase
C0216_RS03865	COG2986	histidine ammonia-lyase
C0216_RS03880	COG1376	ErfK ybiS ycfS ynhG family protein
C0216_RS03895	COG1064	alcohol dehydrogenase
C0216_RS03900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0216_RS03935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0216_RS03950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0216_RS03960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0216_RS03970	COG3903	Transcriptional regulator
C0216_RS03970	COG3629	intracellular signal transduction
C0216_RS03975	COG1522	sequence-specific DNA binding
C0216_RS03990	COG1331	Highly conserved protein containing a thioredoxin domain
C0216_RS04000	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C0216_RS04030	COG1132	(ABC) transporter
C0216_RS04065	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C0216_RS04145	COG2885	chlorophyll binding
C0216_RS04190	COG1653	transport
C0216_RS04205	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C0216_RS04210	COG0667	Aldo Keto reductase
C0216_RS04215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0216_RS04220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0216_RS04240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0216_RS04245	COG0450	alkyl hydroperoxide reductase
C0216_RS04270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0216_RS04285	COG0114	fumarate hydratase activity
C0216_RS04325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C0216_RS04325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C0216_RS04350	COG0778	Nitroreductase
C0216_RS04355	COG1722	exodeoxyribonuclease VII activity
C0216_RS04360	COG1570	exodeoxyribonuclease VII activity
C0216_RS04365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0216_RS04380	COG0012	GTP binding
C0216_RS04400	COG1846	Transcriptional regulator
C0216_RS04480	COG1053	succinate dehydrogenase
C0216_RS04500	COG1217	gtp-binding protein TYPA
C0216_RS04510	COG0601	transmembrane transport
C0216_RS04515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0216_RS04525	COG4608	Belongs to the ABC transporter superfamily
C0216_RS04535	COG4166	transmembrane transport
C0216_RS04540	COG0601	transmembrane transport
C0216_RS04545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0216_RS04550	COG0444	Belongs to the ABC transporter superfamily
C0216_RS04555	COG4608	Belongs to the ABC transporter superfamily
C0216_RS04565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0216_RS04610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0216_RS04615	COG1611	Belongs to the LOG family
C0216_RS04620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0216_RS04630	COG0519	Catalyzes the synthesis of GMP from XMP
C0216_RS04635	COG1024	Enoyl-CoA hydratase
C0216_RS04655	COG1595	DNA-templated transcription, initiation
C0216_RS04665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0216_RS04670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0216_RS04705	COG0598	Magnesium transport protein CorA
C0216_RS04720	COG0613	PHP domain protein
C0216_RS04725	COG2095	MarC family integral membrane protein
C0216_RS04730	COG0596	Alpha beta hydrolase
C0216_RS04825	COG0210	DNA helicase
C0216_RS04870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0216_RS04925	COG3480	Lon protease (S16) C-terminal proteolytic domain
C0216_RS04935	COG1615	UPF0182 protein
C0216_RS04960	COG0753	catalase activity
C0216_RS04970	COG0483	inositol monophosphate 1-phosphatase activity
C0216_RS04980	COG2076	Multidrug Resistance protein
C0216_RS04985	COG1162	GTPase activity
C0216_RS04990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0216_RS05000	COG2135	peptidase activity
C0216_RS05010	COG1595	DNA-templated transcription, initiation
C0216_RS05015	COG5662	AntiSigma factor
C0216_RS05025	COG0242	peptide deformylase activity
C0216_RS05055	COG1966	Carbon starvation protein
C0216_RS05060	COG2188	Transcriptional regulator
C0216_RS05065	COG2182	Extracellular solute-binding protein
C0216_RS05070	COG1175	transmembrane transport
C0216_RS05075	COG0395	ABC-type sugar transport system, permease component
C0216_RS05080	COG1472	Belongs to the glycosyl hydrolase 3 family
C0216_RS05085	COG0363	glucosamine-6-phosphate deaminase activity
C0216_RS05100	COG1597	lipid kinase activity
C0216_RS05155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0216_RS05190	COG1017	nitric oxide dioxygenase activity
C0216_RS05190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0216_RS05195	COG1959	2 iron, 2 sulfur cluster binding
C0216_RS05200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0216_RS05205	COG0142	geranyltranstransferase activity
C0216_RS05210	COG0456	acetyltransferase
C0216_RS05235	COG0604	alcohol dehydrogenase
C0216_RS05250	COG0765	amino acid transport
C0216_RS05255	COG1126	abc transporter atp-binding protein
C0216_RS05260	COG4106	trans-aconitate 2-methyltransferase activity
C0216_RS05400	COG0567	Dehydrogenase, E1 component
C0216_RS05400	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0216_RS05405	COG2205	protein histidine kinase activity
C0216_RS05410	COG0745	RESPONSE REGULATOR receiver
C0216_RS05430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0216_RS05490	COG0772	Belongs to the SEDS family
C0216_RS05525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C0216_RS05530	COG1793	dna ligase
C0216_RS05530	COG3285	dna ligase
C0216_RS05535	COG1793	dna ligase
C0216_RS05595	COG0019	diaminopimelate decarboxylase activity
C0216_RS05600	COG0460	homoserine dehydrogenase
C0216_RS05605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0216_RS05610	COG0083	homoserine kinase activity
C0216_RS05625	COG0254	rRNA binding
C0216_RS05630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0216_RS05635	COG2890	protein-(glutamine-N5) methyltransferase activity
C0216_RS05645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0216_RS05650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0216_RS05670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0216_RS05675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0216_RS05680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0216_RS05685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0216_RS05690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0216_RS05695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0216_RS05700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0216_RS05715	COG2197	response regulator
C0216_RS05720	COG4585	Histidine kinase
C0216_RS05735	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0216_RS05750	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C0216_RS05775	COG1131	(ABC) transporter
C0216_RS05805	COG0183	Belongs to the thiolase family
C0216_RS05870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS05870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS05910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0216_RS05915	COG0857	belongs to the CobB CobQ family
C0216_RS05915	COG0280	phosphate acetyltransferase
C0216_RS05920	COG0205	6-phosphofructokinase activity
C0216_RS05930	COG0789	Transcriptional regulator
C0216_RS05935	COG3118	belongs to the thioredoxin family
C0216_RS05950	COG0366	Alpha amylase catalytic
C0216_RS05955	COG0366	Alpha amylase catalytic
C0216_RS05960	COG0058	SHG alpha-glucan phosphorylase activity
C0216_RS05975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0216_RS05980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0216_RS05985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C0216_RS06000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0216_RS06030	COG0489	protein tyrosine kinase activity
C0216_RS06035	COG0297	glycogen (starch) synthase activity
C0216_RS06055	COG1846	Transcriptional regulator
C0216_RS06065	COG1376	ErfK ybiS ycfS ynhG family protein
C0216_RS06115	COG1695	Transcriptional regulator
C0216_RS06120	COG1122	ATPase activity
C0216_RS06130	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C0216_RS06135	COG0310	cobalt ion transport
C0216_RS06150	COG1760	l-serine dehydratase
C0216_RS06155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0216_RS06160	COG0509	glycine decarboxylation via glycine cleavage system
C0216_RS06165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0216_RS06185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0216_RS06190	COG0747	negative chemotaxis
C0216_RS06195	COG0601	transmembrane transport
C0216_RS06200	COG0444	Belongs to the ABC transporter superfamily
C0216_RS06205	COG4608	Belongs to the ABC transporter superfamily
C0216_RS06210	COG2860	membrane
C0216_RS06230	COG0482	sulfurtransferase activity
C0216_RS06260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0216_RS06270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0216_RS06275	COG0154	amidase activity
C0216_RS06285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0216_RS06300	COG2318	DinB family
C0216_RS06315	COG2409	Drug exporters of the RND superfamily
C0216_RS06325	COG2133	pyrroloquinoline quinone binding
C0216_RS06330	COG0667	Aldo Keto reductase
C0216_RS06350	COG0440	acetolactate synthase activity
C0216_RS06355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0216_RS06360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0216_RS06365	COG3835	regulator
C0216_RS06370	COG0506	proline dehydrogenase activity
C0216_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS06380	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C0216_RS06380	COG0778	Nitroreductase
C0216_RS06390	COG2130	NADP-dependent
C0216_RS06395	COG0583	DNA-binding transcription factor activity
C0216_RS06400	COG0473	3-isopropylmalate dehydrogenase activity
C0216_RS06405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0216_RS06415	COG0831	urea catabolic process
C0216_RS06415	COG0832	Belongs to the urease beta subunit family
C0216_RS06420	COG0804	urea catabolic process
C0216_RS06425	COG2957	Belongs to the agmatine deiminase family
C0216_RS06430	COG1309	transcriptional regulator
C0216_RS06435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0216_RS06450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0216_RS06470	COG2018	Roadblock/LC7 domain
C0216_RS06490	COG2018	Roadblock/LC7 domain
C0216_RS06495	COG5002	protein histidine kinase activity
C0216_RS06505	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0216_RS06510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0216_RS06515	COG1011	Hydrolase
C0216_RS06545	COG1414	Transcriptional regulator
C0216_RS06550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0216_RS06555	COG0066	3-isopropylmalate dehydratase activity
C0216_RS06565	COG0776	regulation of translation
C0216_RS06570	COG1920	GTP binding
C0216_RS06580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0216_RS06585	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0216_RS06605	COG0351	phosphomethylpyrimidine kinase
C0216_RS06610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0216_RS06615	COG1461	Dihydroxyacetone kinase
C0216_RS06625	COG0742	ribosomal rna small subunit methyltransferase
C0216_RS06630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0216_RS06645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0216_RS06650	COG0571	ribonuclease III activity
C0216_RS06655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0216_RS06660	COG1733	regulation of RNA biosynthetic process
C0216_RS06665	COG2340	Cysteine-rich secretory protein family
C0216_RS06670	COG1254	Belongs to the acylphosphatase family
C0216_RS06685	COG0477	Major facilitator Superfamily
C0216_RS06725	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C0216_RS06735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0216_RS06745	COG0442	prolyl-tRNA aminoacylation
C0216_RS06755	COG0228	four-way junction DNA binding
C0216_RS06760	COG1837	Belongs to the UPF0109 family
C0216_RS06765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0216_RS06770	COG0336	Belongs to the RNA methyltransferase TrmD family
C0216_RS06775	COG0335	large ribosomal subunit rRNA binding
C0216_RS06800	COG1051	belongs to the nudix hydrolase family
C0216_RS06810	COG0792	nuclease activity
C0216_RS06825	COG1191	sigma factor activity
C0216_RS06840	COG0052	Belongs to the universal ribosomal protein uS2 family
C0216_RS06845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0216_RS06850	COG0528	UMP kinase activity
C0216_RS06855	COG0233	cytoplasmic translational termination
C0216_RS06860	COG0575	Belongs to the CDS family
C0216_RS06865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0216_RS06880	COG3842	ATPase activity
C0216_RS06900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0216_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS06925	COG0584	glycerophosphoryl diester phosphodiesterase
C0216_RS06930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0216_RS06950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C0216_RS06955	COG3842	ATPase activity
C0216_RS06960	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0216_RS06965	COG1177	transmembrane transport
C0216_RS06970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0216_RS06995	COG2508	Transcriptional regulator
C0216_RS07000	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS07010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C0216_RS07055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0216_RS07060	COG0750	zinc metalloprotease
C0216_RS07065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0216_RS07085	COG0442	prolyl-tRNA aminoacylation
C0216_RS07090	COG0330	HflC and HflK could
C0216_RS07110	COG0779	Required for maturation of 30S ribosomal subunits
C0216_RS07125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0216_RS07135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0216_RS07140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0216_RS07150	COG0455	bacterial-type flagellum organization
C0216_RS07170	COG1404	Belongs to the peptidase S8 family
C0216_RS07190	COG1674	ftsk spoiiie
C0216_RS07200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0216_RS07205	COG1185	polyribonucleotide nucleotidyltransferase activity
C0216_RS07210	COG0612	Peptidase, M16
C0216_RS07215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0216_RS07235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C0216_RS07240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0216_RS07245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0216_RS07270	COG2208	phosphoserine phosphatase activity
C0216_RS07270	COG2770	Histidine kinase
C0216_RS07275	COG4999	Histidine kinase
C0216_RS07275	COG3850	Histidine kinase
C0216_RS07275	COG3437	response regulator, receiver
C0216_RS07275	COG2205	protein histidine kinase activity
C0216_RS07285	COG1674	ftsk spoiiie
C0216_RS07295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0216_RS07305	COG1546	Belongs to the CinA family
C0216_RS07305	COG1058	Belongs to the CinA family
C0216_RS07310	COG1396	sequence-specific DNA binding
C0216_RS07320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0216_RS07330	COG1201	RNA secondary structure unwinding
C0216_RS07335	COG2207	Transcriptional regulator
C0216_RS07335	COG1917	Cupin 2, conserved barrel domain protein
C0216_RS07365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C0216_RS07380	COG0765	amino acid transport
C0216_RS07385	COG0765	amino acid transport
C0216_RS07390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0216_RS07395	COG1126	abc transporter atp-binding protein
C0216_RS07400	COG0745	RESPONSE REGULATOR receiver
C0216_RS07405	COG2205	protein histidine kinase activity
C0216_RS07430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0216_RS07450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0216_RS07460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0216_RS07465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0216_RS07475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0216_RS07505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0216_RS07510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0216_RS07515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0216_RS07525	COG0588	phosphoglycerate mutase activity
C0216_RS07540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0216_RS07555	COG0514	ATP-dependent DNA helicase (RecQ)
C0216_RS07560	COG2197	response regulator
C0216_RS07565	COG4585	Histidine kinase
C0216_RS07585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0216_RS07590	COG2226	methyltransferase
C0216_RS07620	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0216_RS07645	COG1942	4-Oxalocrotonate Tautomerase
C0216_RS07695	COG2814	Major facilitator Superfamily
C0216_RS07720	COG0667	Aldo Keto reductase
C0216_RS07725	COG1960	acyl-CoA dehydrogenase activity
C0216_RS07755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0216_RS07780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0216_RS07785	COG4565	transcriptional regulatory protein
C0216_RS07790	COG3290	protein histidine kinase activity
C0216_RS07800	COG0372	Belongs to the citrate synthase family
C0216_RS07815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0216_RS07820	COG0612	Peptidase, M16
C0216_RS07835	COG1802	Transcriptional regulator
C0216_RS07840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0216_RS07845	COG0045	succinate-CoA ligase (ADP-forming) activity
C0216_RS07845	COG1042	CoA-binding domain protein
C0216_RS07845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0216_RS07860	COG1435	thymidine kinase activity
C0216_RS07890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0216_RS07900	COG0745	RESPONSE REGULATOR receiver
C0216_RS07905	COG2205	protein histidine kinase activity
C0216_RS07930	COG0756	dUTP diphosphatase activity
C0216_RS07955	COG0569	domain protein
C0216_RS07960	COG0531	amino acid
C0216_RS07965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0216_RS07970	COG1132	(ABC) transporter
C0216_RS08000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0216_RS08000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0216_RS08010	COG2197	response regulator
C0216_RS08015	COG4585	Histidine kinase
C0216_RS08025	COG1309	transcriptional regulator
C0216_RS08075	COG1201	RNA secondary structure unwinding
C0216_RS08165	COG0523	cobalamin synthesis protein
C0216_RS08195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0216_RS08200	COG0569	domain protein
C0216_RS08215	COG1120	ATPase activity
C0216_RS08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS08250	COG1595	DNA-templated transcription, initiation
C0216_RS08265	COG0252	asparaginase activity
C0216_RS08275	COG4566	intracellular signal transduction
C0216_RS08300	COG0612	Peptidase, M16
C0216_RS08315	COG1131	(ABC) transporter
C0216_RS08325	COG1132	(ABC) transporter
C0216_RS08360	COG1799	cell septum assembly
C0216_RS08390	COG2040	homocysteine
C0216_RS08400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0216_RS08415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0216_RS08420	COG1024	Enoyl-CoA hydratase
C0216_RS08460	COG0006	proline dipeptidase activity
C0216_RS08490	COG3938	Belongs to the proline racemase family
C0216_RS08525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0216_RS08530	COG0601	transmembrane transport
C0216_RS08535	COG0444	Belongs to the ABC transporter superfamily
C0216_RS08540	COG4608	Belongs to the ABC transporter superfamily
C0216_RS08560	COG2124	cytochrome p450
C0216_RS08565	COG1051	belongs to the nudix hydrolase family
C0216_RS08580	COG1881	PFAM PEBP family protein
C0216_RS08585	COG2207	Transcriptional regulator
C0216_RS08650	COG0563	adenylate kinase activity
C0216_RS08840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0216_RS08855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0216_RS08860	COG1653	transport
C0216_RS08865	COG1175	transmembrane transport
C0216_RS08870	COG0395	ABC-type sugar transport system, permease component
C0216_RS08880	COG4213	ABC transporter substrate-binding protein
C0216_RS08890	COG4214	carbohydrate transport
C0216_RS08895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0216_RS08900	COG0531	amino acid
C0216_RS08905	COG1316	TRANSCRIPTIONal
C0216_RS08945	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0216_RS08945	COG1024	Enoyl-CoA hydratase
C0216_RS08950	COG0183	Belongs to the thiolase family
C0216_RS08955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C0216_RS08970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0216_RS08975	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0216_RS08985	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C0216_RS08990	COG3253	May function as heme-dependent peroxidase
C0216_RS09000	COG3220	belongs to the UPF0276 family
C0216_RS09050	COG0730	response to heat
C0216_RS09090	COG3385	transposase activity
C0216_RS09130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0216_RS09135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0216_RS09145	COG2197	response regulator
C0216_RS09160	COG2197	response regulator
C0216_RS09160	COG3903	Transcriptional regulator
C0216_RS09170	COG2124	cytochrome p450
C0216_RS09200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS09210	COG3251	PFAM MbtH domain protein
C0216_RS09230	COG1216	Glycosyl transferase, family 2
C0216_RS09235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0216_RS09255	COG0504	CTP synthase activity
C0216_RS09325	COG1864	DNA RNA non-specific endonuclease
C0216_RS09325	COG3591	Belongs to the peptidase S1B family
C0216_RS09340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0216_RS09345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0216_RS09345	COG1116	anion transmembrane transporter activity
C0216_RS09365	COG0529	Catalyzes the synthesis of activated sulfate
C0216_RS09370	COG0175	sulfate reduction
C0216_RS09380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0216_RS09400	COG1162	GTPase activity
C0216_RS09450	COG1802	Transcriptional regulator
C0216_RS09460	COG3835	regulator
C0216_RS09475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C0216_RS09480	COG2252	PERMEase
C0216_RS09565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0216_RS09570	COG0386	Belongs to the glutathione peroxidase family
C0216_RS09580	COG3960	tartronate-semialdehyde synthase activity
C0216_RS09600	COG0753	catalase activity
C0216_RS09605	COG2084	Dehydrogenase
C0216_RS09610	COG3622	Belongs to the hyi family
C0216_RS09630	COG2351	hydroxyisourate hydrolase activity
C0216_RS09645	COG2233	PERMEase
C0216_RS09660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0216_RS09670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0216_RS09680	COG2197	response regulator
C0216_RS09695	COG0577	efflux transmembrane transporter activity
C0216_RS09695	COG1136	(ABC) transporter
C0216_RS09700	COG1414	Transcriptional regulator
C0216_RS09705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0216_RS09710	COG4266	Belongs to the allantoicase family
C0216_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS09730	COG0673	inositol 2-dehydrogenase activity
C0216_RS09740	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0216_RS09750	COG1940	carbohydrate kinase activity
C0216_RS09780	COG1376	ErfK ybiS ycfS ynhG family protein
C0216_RS09795	COG0745	RESPONSE REGULATOR receiver
C0216_RS09800	COG2205	protein histidine kinase activity
C0216_RS09810	COG2124	cytochrome p450
C0216_RS09820	COG0405	Gamma-glutamyltransferase
C0216_RS09860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0216_RS09875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0216_RS09910	COG1126	abc transporter atp-binding protein
C0216_RS09920	COG0765	amino acid transport
C0216_RS09925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0216_RS09930	COG5285	phytanoyl-CoA dioxygenase
C0216_RS09935	COG1917	Cupin 2, conserved barrel domain protein
C0216_RS09945	COG0456	acetyltransferase
C0216_RS09955	COG1253	flavin adenine dinucleotide binding
C0216_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS09990	COG4175	Glycine betaine
C0216_RS09990	COG0517	IMP dehydrogenase activity
C0216_RS10020	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C0216_RS10025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0216_RS10030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS10040	COG1132	(ABC) transporter
C0216_RS10045	COG1132	(ABC) transporter
C0216_RS10050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS10055	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS10060	COG1120	ATPase activity
C0216_RS10080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0216_RS10085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0216_RS10090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0216_RS10100	COG0483	inositol monophosphate 1-phosphatase activity
C0216_RS10110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C0216_RS10145	COG0640	Transcriptional regulator
C0216_RS10155	COG0514	ATP-dependent DNA helicase (RecQ)
C0216_RS10160	COG0346	lactoylglutathione lyase activity
C0216_RS10165	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0216_RS10180	COG1929	Belongs to the glycerate kinase type-1 family
C0216_RS10210	COG0688	phosphatidylethanolamine metabolic process
C0216_RS10215	COG1960	acyl-CoA dehydrogenase activity
C0216_RS10225	COG2301	Belongs to the HpcH HpaI aldolase family
C0216_RS10230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS10230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0216_RS10235	COG0604	alcohol dehydrogenase
C0216_RS10245	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0216_RS10265	COG2362	D-Aminopeptidase
C0216_RS10270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0216_RS10290	COG0010	Belongs to the arginase family
C0216_RS10335	COG0531	amino acid
C0216_RS10340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0216_RS10350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0216_RS10385	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0216_RS10395	COG0656	L-ascorbic acid biosynthetic process
C0216_RS10410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0216_RS10415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0216_RS10445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0216_RS10480	COG1486	melibiose metabolic process
C0216_RS10485	COG1051	belongs to the nudix hydrolase family
C0216_RS10500	COG1793	dna ligase
C0216_RS10520	COG0488	(ABC) transporter
C0216_RS10540	COG1515	deoxyribonuclease V activity
C0216_RS10545	COG3268	Saccharopine dehydrogenase
C0216_RS10560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0216_RS10570	COG1960	acyl-CoA dehydrogenase activity
C0216_RS10575	COG0183	Belongs to the thiolase family
C0216_RS10580	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0216_RS10580	COG1024	Enoyl-CoA hydratase
C0216_RS10590	COG0789	Transcriptional regulator
C0216_RS10640	COG2183	response to ionizing radiation
C0216_RS10655	COG4221	oxidoreductase activity
C0216_RS10660	COG0488	(ABC) transporter
C0216_RS10665	COG4977	sequence-specific DNA binding
C0216_RS10675	COG1024	Enoyl-CoA hydratase
C0216_RS10690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0216_RS10695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C0216_RS10700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0216_RS10730	COG1134	teichoic acid transport
C0216_RS10735	COG1562	ergosterol biosynthetic process
C0216_RS10745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C0216_RS10755	COG1657	PFAM Prenyltransferase squalene oxidase
C0216_RS10775	COG2365	Tyrosine phosphatase family
C0216_RS10780	COG0739	heme binding
C0216_RS10785	COG2755	lipolytic protein G-D-S-L family
C0216_RS10825	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS10840	COG1136	(ABC) transporter
C0216_RS10840	COG0577	efflux transmembrane transporter activity
C0216_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS10850	COG1169	isochorismate synthase
C0216_RS10855	COG1021	2,3-dihydroxybenzoate-AMP ligase
C0216_RS10860	COG3433	isochorismatase activity
C0216_RS10860	COG1535	isochorismatase
C0216_RS10870	COG2375	cellular response to nickel ion
C0216_RS10875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0216_RS10880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS10885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS10890	COG1120	ATPase activity
C0216_RS10905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0216_RS10945	COG3958	Transketolase
C0216_RS10950	COG3959	Transketolase, thiamine diphosphate binding domain
C0216_RS11020	COG3848	Pyruvate phosphate dikinase
C0216_RS11020	COG0574	Belongs to the PEP-utilizing enzyme family
C0216_RS11025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C0216_RS11030	COG1213	nucleotidyl transferase
C0216_RS11035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0216_RS11170	COG0085	RNA polymerase activity
C0216_RS11185	COG0542	response to heat
C0216_RS11260	COG2197	response regulator
C0216_RS11265	COG4585	Histidine kinase
C0216_RS11270	COG2409	Drug exporters of the RND superfamily
C0216_RS11275	COG0659	secondary active sulfate transmembrane transporter activity
C0216_RS11280	COG0789	Transcriptional regulator
C0216_RS11285	COG2188	Transcriptional regulator
C0216_RS11305	COG3842	ATPase activity
C0216_RS11315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0216_RS11320	COG0640	Transcriptional regulator
C0216_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS11355	COG1937	Protein conserved in bacteria
C0216_RS11370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0216_RS11380	COG0438	transferase activity, transferring glycosyl groups
C0216_RS11400	COG2364	Membrane
C0216_RS11415	COG2124	cytochrome p450
C0216_RS11420	COG3424	synthase
C0216_RS11425	COG2124	cytochrome p450
C0216_RS11455	COG0583	DNA-binding transcription factor activity
C0216_RS11465	COG0598	Magnesium transport protein CorA
C0216_RS11470	COG3152	Membrane
C0216_RS11475	COG2838	Isocitrate dehydrogenase
C0216_RS11490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0216_RS11500	COG0247	lactate metabolic process
C0216_RS11505	COG1139	Iron-sulfur cluster binding protein
C0216_RS11510	COG1556	Lactate utilization protein
C0216_RS11540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0216_RS11555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0216_RS11620	COG1024	Enoyl-CoA hydratase
C0216_RS11645	COG3345	alpha-galactosidase
C0216_RS11655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0216_RS11675	COG1175	transmembrane transport
C0216_RS11680	COG0395	ABC-type sugar transport system, permease component
C0216_RS11690	COG1902	pentaerythritol trinitrate reductase activity
C0216_RS11690	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0216_RS11705	COG0596	Alpha beta hydrolase
C0216_RS11760	COG2329	Antibiotic biosynthesis monooxygenase
C0216_RS11770	COG2824	Alkylphosphonate utilization operon protein PhnA
C0216_RS11795	COG0475	glutathione-regulated potassium exporter activity
C0216_RS11810	COG0640	Transcriptional regulator
C0216_RS11820	COG2072	flavoprotein involved in K transport
C0216_RS11825	COG1247	-acetyltransferase
C0216_RS11830	COG0640	Transcriptional regulator
C0216_RS11835	COG0492	ferredoxin-NADP+ reductase activity
C0216_RS11855	COG4326	sporulation control protein
C0216_RS11900	COG2217	Heavy metal translocating P-type atpase
C0216_RS11945	COG2124	cytochrome p450
C0216_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS11995	COG0596	Alpha beta hydrolase
C0216_RS12015	COG0475	glutathione-regulated potassium exporter activity
C0216_RS12085	COG2124	cytochrome p450
C0216_RS12090	COG1917	Cupin 2, conserved barrel domain protein
C0216_RS12090	COG4977	sequence-specific DNA binding
C0216_RS12195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0216_RS12205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS12210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C0216_RS12220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0216_RS12225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0216_RS12230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0216_RS12235	COG0254	rRNA binding
C0216_RS12245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0216_RS12255	COG1840	ABC-type Fe3 transport system, periplasmic component
C0216_RS12265	COG3842	ATPase activity
C0216_RS12295	COG2801	Transposase and inactivated derivatives
C0216_RS12345	COG2226	methyltransferase
C0216_RS12420	COG0443	Heat shock 70 kDa protein
C0216_RS12425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C0216_RS12435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C0216_RS12480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0216_RS12505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0216_RS12505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0216_RS12510	COG0726	polysaccharide deacetylase
C0216_RS12565	COG0583	DNA-binding transcription factor activity
C0216_RS12575	COG1053	succinate dehydrogenase
C0216_RS12580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0216_RS12595	COG4651	solute:proton antiporter activity
C0216_RS12595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0216_RS12615	COG2182	Extracellular solute-binding protein
C0216_RS12630	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C0216_RS12635	COG0121	glutamine amidotransferase
C0216_RS12640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C0216_RS12655	COG1609	Transcriptional regulator
C0216_RS12660	COG0183	Belongs to the thiolase family
C0216_RS12680	COG3321	synthase
C0216_RS12680	COG0604	alcohol dehydrogenase
C0216_RS12695	COG0604	alcohol dehydrogenase
C0216_RS12695	COG3321	synthase
C0216_RS12710	COG0604	alcohol dehydrogenase
C0216_RS12710	COG0604	alcohol dehydrogenase
C0216_RS12710	COG3321	synthase
C0216_RS12710	COG3321	synthase
C0216_RS12735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0216_RS12775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0216_RS12780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0216_RS12800	COG0789	Transcriptional regulator
C0216_RS12805	COG2813	Specifically methylates the guanine in position
C0216_RS12825	COG0028	Belongs to the TPP enzyme family
C0216_RS12830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0216_RS12860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C0216_RS12865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C0216_RS12870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C0216_RS12900	COG1131	(ABC) transporter
C0216_RS12910	COG1733	regulation of RNA biosynthetic process
C0216_RS12920	COG5002	protein histidine kinase activity
C0216_RS12925	COG0745	RESPONSE REGULATOR receiver
C0216_RS12930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0216_RS12935	COG1115	amino acid carrier protein
C0216_RS12955	COG0659	secondary active sulfate transmembrane transporter activity
C0216_RS12960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C0216_RS12975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0216_RS12980	COG1131	(ABC) transporter
C0216_RS12995	COG0516	GMP reductase activity
C0216_RS12995	COG0517	IMP dehydrogenase activity
C0216_RS13010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0216_RS13035	COG0517	IMP dehydrogenase activity
C0216_RS13040	COG2239	Acts as a magnesium transporter
C0216_RS13050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0216_RS13050	COG0617	tRNA 3'-terminal CCA addition
C0216_RS13050	COG0517	IMP dehydrogenase activity
C0216_RS13075	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0216_RS13075	COG0022	dehydrogenase e1 component
C0216_RS13080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C0216_RS13085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0216_RS13180	COG1160	GTP binding
C0216_RS13185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0216_RS13195	COG0297	glycogen (starch) synthase activity
C0216_RS13220	COG2124	cytochrome p450
C0216_RS13270	COG3290	protein histidine kinase activity
C0216_RS13285	COG1191	sigma factor activity
C0216_RS13290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0216_RS13295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C0216_RS13345	COG0393	Putative heavy-metal-binding
C0216_RS13370	COG0328	RNA-DNA hybrid ribonuclease activity
C0216_RS13380	COG2814	Major facilitator Superfamily
C0216_RS13395	COG2356	endonuclease I
C0216_RS13400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0216_RS13425	COG3864	Putative metallopeptidase domain
C0216_RS13465	COG0515	serine threonine protein kinase
C0216_RS13465	COG2815	serine threonine protein kinase
C0216_RS13500	COG3321	synthase
C0216_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS13500	COG0604	alcohol dehydrogenase
C0216_RS13505	COG1960	acyl-CoA dehydrogenase activity
C0216_RS13510	COG1960	acyl-CoA dehydrogenase activity
C0216_RS13525	COG2304	oxidoreductase activity
C0216_RS13545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C0216_RS13570	COG1301	dicarboxylic acid transport
C0216_RS13575	COG3290	protein histidine kinase activity
C0216_RS13580	COG4565	transcriptional regulatory protein
C0216_RS13595	COG0076	glutamate decarboxylase activity
C0216_RS13605	COG2340	Cysteine-rich secretory protein family
C0216_RS13615	COG0667	Aldo Keto reductase
C0216_RS13630	COG1131	(ABC) transporter
C0216_RS13635	COG1793	dna ligase
C0216_RS13665	COG0477	Major facilitator Superfamily
C0216_RS13670	COG4412	M6 family metalloprotease domain protein
C0216_RS13670	COG1404	Belongs to the peptidase S8 family
C0216_RS13670	COG4412	M6 family metalloprotease domain protein
C0216_RS13670	COG1404	Belongs to the peptidase S8 family
C0216_RS13695	COG3265	gluconokinase activity
C0216_RS13705	COG1132	(ABC) transporter
C0216_RS13740	COG2226	methyltransferase
C0216_RS13745	COG4264	IucA IucC family
C0216_RS13755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0216_RS13760	COG1191	sigma factor activity
C0216_RS13765	COG4175	Glycine betaine
C0216_RS13765	COG0517	IMP dehydrogenase activity
C0216_RS13800	COG0583	DNA-binding transcription factor activity
C0216_RS13830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0216_RS13850	COG0714	Associated with various cellular activities
C0216_RS13895	COG1796	DNA polymerase
C0216_RS13895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0216_RS13980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0216_RS14125	COG2814	Major facilitator Superfamily
C0216_RS14175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0216_RS14200	COG2272	Belongs to the type-B carboxylesterase lipase family
C0216_RS14255	COG3655	Transcriptional regulator
C0216_RS14335	COG0154	amidase activity
C0216_RS14365	COG0659	secondary active sulfate transmembrane transporter activity
C0216_RS14385	COG4989	oxidoreductase activity
C0216_RS14390	COG0435	Glutathione S-transferase
C0216_RS14415	COG0277	FAD linked oxidase domain protein
C0216_RS14425	COG2072	flavoprotein involved in K transport
C0216_RS14465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0216_RS14500	COG0492	ferredoxin-NADP+ reductase activity
C0216_RS14510	COG1309	transcriptional regulator
C0216_RS14520	COG0506	proline dehydrogenase activity
C0216_RS14535	COG0531	amino acid
C0216_RS14565	COG2340	Cysteine-rich secretory protein family
C0216_RS14575	COG1136	(ABC) transporter
C0216_RS14585	COG1653	transport
C0216_RS14590	COG0366	Alpha amylase catalytic
C0216_RS14595	COG1653	transport
C0216_RS14600	COG1175	transmembrane transport
C0216_RS14605	COG0395	ABC-type sugar transport system, permease component
C0216_RS14655	COG0488	(ABC) transporter
C0216_RS14670	COG1120	ATPase activity
C0216_RS14675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS14680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0216_RS14685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0216_RS14690	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0216_RS14695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0216_RS14705	COG1278	Cold shock
C0216_RS14725	COG0142	geranyltranstransferase activity
C0216_RS14745	COG0493	'glutamate synthase
C0216_RS14745	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C0216_RS14780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0216_RS14780	COG0723	plastoquinol--plastocyanin reductase activity
C0216_RS14845	COG1982	Orn Lys Arg decarboxylase major
C0216_RS14850	COG1191	sigma factor activity
C0216_RS14880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0216_RS14905	COG4941	Belongs to the sigma-70 factor family
C0216_RS14910	COG3795	YCII-related domain
C0216_RS14920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0216_RS14930	COG1473	amidohydrolase
C0216_RS14955	COG0745	RESPONSE REGULATOR receiver
C0216_RS14960	COG2205	protein histidine kinase activity
C0216_RS14965	COG1136	(ABC) transporter
C0216_RS14965	COG0577	efflux transmembrane transporter activity
C0216_RS14970	COG1136	(ABC) transporter
C0216_RS14970	COG0577	efflux transmembrane transporter activity
C0216_RS14985	COG1846	Transcriptional regulator
C0216_RS14990	COG2409	Drug exporters of the RND superfamily
C0216_RS15015	COG2770	Histidine kinase
C0216_RS15015	COG2208	phosphoserine phosphatase activity
C0216_RS15035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0216_RS15050	COG1335	isochorismatase
C0216_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS15060	COG1595	DNA-templated transcription, initiation
C0216_RS15070	COG2326	polyphosphate kinase activity
C0216_RS15115	COG2124	cytochrome p450
C0216_RS15140	COG0395	ABC-type sugar transport system, permease component
C0216_RS15185	COG0367	asparagine synthase
C0216_RS15200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C0216_RS15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0216_RS15235	COG0431	NADPH-dependent FMN reductase
C0216_RS15240	COG0187	DNA topoisomerase II activity
C0216_RS15245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C0216_RS15290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0216_RS15325	COG2197	response regulator
C0216_RS15335	COG1819	glycosyl
C0216_RS15340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0216_RS15365	COG0009	L-threonylcarbamoyladenylate synthase
C0216_RS15375	COG0596	Alpha beta hydrolase
C0216_RS15440	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C0216_RS15465	COG3046	protein related to deoxyribodipyrimidine photolyase
C0216_RS15505	COG4249	Peptidase C14 caspase catalytic subunit p20
C0216_RS15505	COG2319	Wd-40 repeat
C0216_RS15530	COG1309	transcriptional regulator
C0216_RS15560	COG0574	Belongs to the PEP-utilizing enzyme family
C0216_RS15560	COG3848	Pyruvate phosphate dikinase
C0216_RS15610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0216_RS15685	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C0216_RS15685	COG5479	isomerase activity
C0216_RS15750	COG2770	Histidine kinase
C0216_RS15750	COG2208	phosphoserine phosphatase activity
C0216_RS15765	COG2197	response regulator
C0216_RS15775	COG2409	Drug exporters of the RND superfamily
C0216_RS15795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0216_RS15805	COG4106	trans-aconitate 2-methyltransferase activity
C0216_RS15820	COG0583	DNA-binding transcription factor activity
C0216_RS15840	COG0596	Alpha beta hydrolase
C0216_RS15920	COG1595	DNA-templated transcription, initiation
C0216_RS15940	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS15960	COG0667	Aldo Keto reductase
C0216_RS15965	COG3511	phospholipase C
C0216_RS15970	COG1278	Cold shock
C0216_RS16015	COG0492	ferredoxin-NADP+ reductase activity
C0216_RS16015	COG3118	belongs to the thioredoxin family
C0216_RS16030	COG2124	cytochrome p450
C0216_RS16035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0216_RS16045	COG1335	isochorismatase
C0216_RS16105	COG2239	Acts as a magnesium transporter
C0216_RS16115	COG0589	response to stress
C0216_RS16130	COG1063	alcohol dehydrogenase
C0216_RS16135	COG0517	IMP dehydrogenase activity
C0216_RS16135	COG0516	GMP reductase activity
C0216_RS16155	COG1271	oxidase subunit
C0216_RS16160	COG1294	oxidase, subunit
C0216_RS16270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0216_RS16275	COG0500	methyltransferase
C0216_RS16310	COG1252	NADH dehydrogenase
C0216_RS16365	COG1819	glycosyl
C0216_RS16370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0216_RS16400	COG0714	Associated with various cellular activities
C0216_RS16410	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS16415	COG0667	Aldo Keto reductase
C0216_RS16450	COG0300	oxidoreductase activity
C0216_RS16460	COG2318	DinB family
C0216_RS16465	COG0038	chloride channel
C0216_RS16485	COG4106	trans-aconitate 2-methyltransferase activity
C0216_RS16615	COG0488	(ABC) transporter
C0216_RS16635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0216_RS16640	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0216_RS16650	COG1295	ribonuclease BN
C0216_RS16740	COG1597	lipid kinase activity
C0216_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS16830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0216_RS16955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0216_RS16965	COG1120	ATPase activity
C0216_RS16985	COG1309	transcriptional regulator
C0216_RS17000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C0216_RS17015	COG4335	DNA alkylation repair
C0216_RS17055	COG2375	cellular response to nickel ion
C0216_RS17055	COG1132	(ABC) transporter
C0216_RS17070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0216_RS17090	COG2226	methyltransferase
C0216_RS17110	COG0432	Pfam Uncharacterised protein family UPF0047
C0216_RS17220	COG0463	Glycosyl transferase, family 2
C0216_RS17265	COG1088	dTDP-glucose 4,6-dehydratase activity
C0216_RS17300	COG1309	transcriptional regulator
C0216_RS17305	COG0488	(ABC) transporter
C0216_RS17310	COG4257	antibiotic catabolic process
C0216_RS17320	COG2197	response regulator
C0216_RS17365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0216_RS17370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0216_RS17420	COG0784	Response regulator, receiver
C0216_RS17420	COG2205	protein histidine kinase activity
C0216_RS17420	COG2198	Histidine kinase
C0216_RS17430	COG1366	Belongs to the anti-sigma-factor antagonist family
C0216_RS17445	COG3629	intracellular signal transduction
C0216_RS17445	COG3903	Transcriptional regulator
C0216_RS17465	COG2197	response regulator
C0216_RS17475	COG1222	aaa ATPase
C0216_RS17485	COG3629	intracellular signal transduction
C0216_RS17485	COG3903	Transcriptional regulator
C0216_RS17585	COG0668	transmembrane transport
C0216_RS17600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0216_RS17615	COG0242	peptide deformylase activity
C0216_RS17625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0216_RS17665	COG1796	DNA polymerase
C0216_RS17665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0216_RS17670	COG0300	oxidoreductase activity
C0216_RS17690	COG1957	nucleoside hydrolase
C0216_RS17715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C0216_RS17720	COG2135	peptidase activity
C0216_RS17735	COG1764	response to oxidative stress
C0216_RS17740	COG1846	Transcriptional regulator
C0216_RS17765	COG0009	L-threonylcarbamoyladenylate synthase
C0216_RS17785	COG0515	serine threonine protein kinase
C0216_RS17785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0216_RS17790	COG1376	ErfK ybiS ycfS ynhG family protein
C0216_RS17810	COG0309	Hydrogenase expression formation protein (HypE)
C0216_RS17830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0216_RS17835	COG0375	protein maturation
C0216_RS17875	COG1024	Enoyl-CoA hydratase
C0216_RS17875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0216_RS17965	COG1505	serine-type exopeptidase activity
C0216_RS17985	COG1960	acyl-CoA dehydrogenase activity
C0216_RS18055	COG2319	Wd-40 repeat
C0216_RS18055	COG4249	Peptidase C14 caspase catalytic subunit p20
C0216_RS18080	COG1131	(ABC) transporter
C0216_RS18085	COG1725	Transcriptional regulator
C0216_RS18105	COG0745	RESPONSE REGULATOR receiver
C0216_RS18175	COG1714	RDD family
C0216_RS18255	COG1404	Belongs to the peptidase S8 family
C0216_RS18315	COG0583	DNA-binding transcription factor activity
C0216_RS18340	COG3118	belongs to the thioredoxin family
C0216_RS18345	COG2124	cytochrome p450
C0216_RS18355	COG1278	Cold shock
C0216_RS18480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0216_RS18490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C0216_RS18525	COG2080	2 iron, 2 sulfur cluster binding
C0216_RS18550	COG1053	succinate dehydrogenase
C0216_RS18575	COG1024	Enoyl-CoA hydratase
C0216_RS18595	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS18600	COG0387	Pfam Sodium calcium exchanger
C0216_RS18610	COG2070	2-Nitropropane dioxygenase
C0216_RS18615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C0216_RS18645	COG2815	serine threonine protein kinase
C0216_RS18645	COG0515	serine threonine protein kinase
C0216_RS18655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0216_RS18660	COG1960	acyl-CoA dehydrogenase activity
C0216_RS18670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0216_RS18675	COG1349	DNA-binding transcription factor activity
C0216_RS18685	COG0156	8-amino-7-oxononanoate synthase activity
C0216_RS18690	COG1063	alcohol dehydrogenase
C0216_RS18700	COG4106	trans-aconitate 2-methyltransferase activity
C0216_RS18710	COG3387	PFAM Glycoside hydrolase 15-related
C0216_RS18715	COG2259	Doxx family
C0216_RS18735	COG2376	Dihydroxyacetone kinase
C0216_RS18740	COG1461	Dihydroxyacetone kinase
C0216_RS18800	COG1716	ATPase activity
C0216_RS18800	COG1131	(ABC) transporter
C0216_RS18800	COG0842	Transport permease protein
C0216_RS18800	COG0842	Transport permease protein
C0216_RS18800	COG1716	ATPase activity
C0216_RS18800	COG1131	(ABC) transporter
C0216_RS18855	COG1397	ADP-ribosylglycohydrolase
C0216_RS18860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0216_RS18865	COG1215	transferase activity, transferring glycosyl groups
C0216_RS18905	COG1940	carbohydrate kinase activity
C0216_RS18925	COG0445	tRNA wobble uridine modification
C0216_RS18935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0216_RS18950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C0216_RS18995	COG0584	glycerophosphoryl diester phosphodiesterase
C0216_RS19025	COG1309	transcriptional regulator
C0216_RS19040	COG0493	'glutamate synthase
C0216_RS19055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0216_RS19070	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C0216_RS19080	COG0406	alpha-ribazole phosphatase activity
C0216_RS19100	COG0702	epimerase
C0216_RS19110	COG2124	cytochrome p450
C0216_RS19115	COG2072	flavoprotein involved in K transport
C0216_RS19125	COG1132	(ABC) transporter
C0216_RS19140	COG1132	(ABC) transporter
C0216_RS19145	COG1132	(ABC) transporter
C0216_RS19160	COG1946	Acyl-CoA thioesterase
C0216_RS19165	COG3012	SEC-C Motif Domain Protein
C0216_RS19175	COG2018	Roadblock/LC7 domain
C0216_RS19220	COG1720	tRNA m6t6A37 methyltransferase activity
C0216_RS19230	COG0154	amidase activity
C0216_RS19260	COG2340	Cysteine-rich secretory protein family
C0216_RS19280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0216_RS19285	COG0785	Cytochrome C biogenesis protein
C0216_RS19295	COG0745	RESPONSE REGULATOR receiver
C0216_RS19300	COG2205	protein histidine kinase activity
C0216_RS19305	COG1063	alcohol dehydrogenase
C0216_RS19315	COG2267	carboxylic ester hydrolase activity
C0216_RS19330	COG2814	Major facilitator Superfamily
C0216_RS19335	COG2814	Major facilitator Superfamily
C0216_RS19340	COG1063	alcohol dehydrogenase
C0216_RS19355	COG1940	carbohydrate kinase activity
C0216_RS19360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0216_RS19425	COG2890	protein-(glutamine-N5) methyltransferase activity
C0216_RS19460	COG1113	amino acid transport
C0216_RS19490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0216_RS19505	COG2409	Drug exporters of the RND superfamily
C0216_RS19530	COG1448	Aminotransferase
C0216_RS19565	COG4608	Belongs to the ABC transporter superfamily
C0216_RS19575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0216_RS19580	COG0601	transmembrane transport
C0216_RS19615	COG1960	acyl-CoA dehydrogenase activity
C0216_RS19625	COG0242	peptide deformylase activity
C0216_RS19635	COG3442	glutamine amidotransferase
C0216_RS19640	COG0205	6-phosphofructokinase activity
C0216_RS19650	COG0204	Acyl-transferase
C0216_RS19660	COG0829	nickel cation binding
C0216_RS19665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0216_RS19675	COG0804	urea catabolic process
C0216_RS19680	COG0832	Belongs to the urease beta subunit family
C0216_RS19685	COG0831	urea catabolic process
C0216_RS19705	COG0156	8-amino-7-oxononanoate synthase activity
C0216_RS19710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0216_RS19715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0216_RS19720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0216_RS19740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0216_RS19765	COG1131	(ABC) transporter
C0216_RS19770	COG4585	Histidine kinase
C0216_RS19775	COG2197	response regulator
C0216_RS19780	COG1940	carbohydrate kinase activity
C0216_RS19785	COG2188	Transcriptional regulator
C0216_RS19810	COG1522	sequence-specific DNA binding
C0216_RS19815	COG0419	ATPase involved in DNA repair
C0216_RS19820	COG0420	3'-5' exonuclease activity
C0216_RS19825	COG1739	Uncharacterized protein family UPF0029
C0216_RS19830	COG1832	CoA-binding protein
C0216_RS19845	COG0110	maltose O-acetyltransferase activity
C0216_RS19860	COG1472	Belongs to the glycosyl hydrolase 3 family
C0216_RS19910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0216_RS19920	COG1968	undecaprenyl-diphosphatase activity
C0216_RS19935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0216_RS19940	COG0673	inositol 2-dehydrogenase activity
C0216_RS19945	COG2318	DinB family
C0216_RS19960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0216_RS20000	COG4326	sporulation control protein
C0216_RS20035	COG1253	flavin adenine dinucleotide binding
C0216_RS20125	COG0395	ABC-type sugar transport system, permease component
C0216_RS20130	COG1175	transmembrane transport
C0216_RS20140	COG1621	beta-fructofuranosidase activity
C0216_RS20145	COG1609	Transcriptional regulator
C0216_RS20155	COG0517	IMP dehydrogenase activity
C0216_RS20155	COG0617	tRNA 3'-terminal CCA addition
C0216_RS20155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0216_RS20205	COG0574	Belongs to the PEP-utilizing enzyme family
C0216_RS20205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0216_RS20260	COG0697	spore germination
C0216_RS20275	COG0697	spore germination
C0216_RS20315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0216_RS20315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0216_RS20325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0216_RS20345	COG1716	ATPase activity
C0216_RS20365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0216_RS20395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0216_RS20405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0216_RS20420	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C0216_RS20445	COG2018	Roadblock/LC7 domain
C0216_RS20475	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0216_RS20480	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C0216_RS20485	COG1984	allophanate hydrolase subunit 2
C0216_RS20510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0216_RS20560	COG1960	acyl-CoA dehydrogenase activity
C0216_RS20580	COG0572	uridine kinase
C0216_RS20605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0216_RS20610	COG0140	phosphoribosyl-ATP diphosphatase activity
C0216_RS20615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0216_RS20620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0216_RS20620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0216_RS20625	COG3201	nicotinamide mononucleotide transporter
C0216_RS20645	COG1595	DNA-templated transcription, initiation
C0216_RS20650	COG1090	epimerase
C0216_RS20655	COG1846	Transcriptional regulator
C0216_RS20655	COG1940	carbohydrate kinase activity
C0216_RS20660	COG0738	Major facilitator superfamily
C0216_RS20665	COG2233	PERMEase
C0216_RS20680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0216_RS20700	COG0531	amino acid
C0216_RS20730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0216_RS20735	COG3275	phosphorelay sensor kinase activity
C0216_RS20760	COG2390	Transcriptional regulator
C0216_RS20765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0216_RS20775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0216_RS20790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0216_RS20805	COG0194	GDP metabolic process
C0216_RS20815	COG0284	orotidine-5'-phosphate decarboxylase activity
C0216_RS20820	COG0167	dihydroorotate dehydrogenase activity
C0216_RS20825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0216_RS20830	COG0505	Belongs to the CarA family
C0216_RS20840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0216_RS20845	COG0540	Belongs to the ATCase OTCase family
C0216_RS20850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C0216_RS20860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0216_RS20865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0216_RS20870	COG0006	proline dipeptidase activity
C0216_RS20880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0216_RS20885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0216_RS20890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C0216_RS20895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0216_RS20900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0216_RS20905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0216_RS20915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0216_RS20920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0216_RS20935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0216_RS20955	COG0124	histidyl-tRNA synthetase
C0216_RS20965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0216_RS20970	COG1196	nuclear chromosome segregation
C0216_RS20975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0216_RS20980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0216_RS20985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0216_RS20990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0216_RS21000	COG2255	four-way junction helicase activity
C0216_RS21005	COG0632	four-way junction helicase activity
C0216_RS21010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0216_RS21015	COG0217	transcriptional regulatory protein
C0216_RS21020	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C0216_RS21025	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C0216_RS21035	COG0438	transferase activity, transferring glycosyl groups
C0216_RS21040	COG1560	Kdo2-lipid A biosynthetic process
C0216_RS21045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0216_RS21065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0216_RS21070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0216_RS21090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0216_RS21155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0216_RS21210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0216_RS21210	COG1648	precorrin-2 dehydrogenase activity
C0216_RS21215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C0216_RS21230	COG1464	Belongs to the NlpA lipoprotein family
C0216_RS21235	COG2011	ABC-type metal ion transport system permease component
C0216_RS21240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0216_RS21270	COG0204	Acyl-transferase
C0216_RS21270	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS21280	COG0477	Major facilitator Superfamily
C0216_RS21300	COG0165	Argininosuccinate lyase
C0216_RS21305	COG0137	argininosuccinate synthase activity
C0216_RS21320	COG1438	arginine binding
C0216_RS21325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0216_RS21330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0216_RS21335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0216_RS21340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0216_RS21345	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS21350	COG2378	regulation of single-species biofilm formation
C0216_RS21380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0216_RS21385	COG0697	spore germination
C0216_RS21395	COG1649	PFAM Uncharacterised BCR, COG1649
C0216_RS21415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0216_RS21415	COG0072	phenylalanine-tRNA ligase activity
C0216_RS21420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0216_RS21425	COG5002	protein histidine kinase activity
C0216_RS21430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0216_RS21435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0216_RS21440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0216_RS21445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0216_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS21490	COG1012	belongs to the aldehyde dehydrogenase family
C0216_RS21495	COG0174	glutamine synthetase
C0216_RS21505	COG1113	amino acid transport
C0216_RS21510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C0216_RS21545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0216_RS21555	COG0564	pseudouridine synthase activity
C0216_RS21560	COG1309	transcriptional regulator
C0216_RS21575	COG0805	protein transport
C0216_RS21580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0216_RS21615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0216_RS21625	COG1609	Transcriptional regulator
C0216_RS21630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0216_RS21635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0216_RS21650	COG4122	O-methyltransferase activity
C0216_RS21655	COG1222	aaa ATPase
C0216_RS21680	COG1994	Peptidase M50
C0216_RS21680	COG0517	IMP dehydrogenase activity
C0216_RS21690	COG2197	response regulator
C0216_RS21695	COG0747	negative chemotaxis
C0216_RS21700	COG4166	transmembrane transport
C0216_RS21710	COG0646	methionine synthase
C0216_RS21710	COG1410	methionine synthase
C0216_RS21715	COG1414	Transcriptional regulator
C0216_RS21720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0216_RS21725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0216_RS21730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0216_RS21740	COG0215	cysteine-tRNA ligase activity
C0216_RS21765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0216_RS21770	COG0667	Aldo Keto reductase
C0216_RS21800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0216_RS21810	COG1113	amino acid transport
C0216_RS21835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0216_RS21840	COG2149	membrane
C0216_RS21875	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS21885	COG3876	Protein conserved in bacteria
C0216_RS21935	COG2851	Citrate transporter
C0216_RS21940	COG3383	formate dehydrogenase (NAD+) activity
C0216_RS21945	COG1309	transcriptional regulator
C0216_RS21965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C0216_RS21970	COG2188	Transcriptional regulator
C0216_RS21985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0216_RS21995	COG0515	serine threonine protein kinase
C0216_RS22000	COG2755	lipolytic protein G-D-S-L family
C0216_RS22010	COG1725	Transcriptional regulator
C0216_RS22025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0216_RS22030	COG0587	DNA-directed DNA polymerase activity
C0216_RS22050	COG1799	cell septum assembly
C0216_RS22055	COG1960	acyl-CoA dehydrogenase activity
C0216_RS22060	COG0477	Major facilitator Superfamily
C0216_RS22070	COG0671	phosphoesterase, PA-phosphatase related
C0216_RS22090	COG1160	GTP binding
C0216_RS22100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0216_RS22125	COG1397	ADP-ribosylglycohydrolase
C0216_RS22130	COG0494	nUDIX hydrolase
C0216_RS22135	COG1187	pseudouridine synthase activity
C0216_RS22140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0216_RS22145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0216_RS22160	COG0686	Belongs to the AlaDH PNT family
C0216_RS22170	COG0494	nUDIX hydrolase
C0216_RS22175	COG0504	CTP synthase activity
C0216_RS22180	COG3387	PFAM Glycoside hydrolase 15-related
C0216_RS22195	COG0297	glycogen (starch) synthase activity
C0216_RS22200	COG0497	DNA recombination
C0216_RS22205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0216_RS22225	COG1120	ATPase activity
C0216_RS22230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS22235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0216_RS22240	COG0647	UMP catabolic process
C0216_RS22275	COG2094	Belongs to the DNA glycosylase MPG family
C0216_RS22285	COG1881	PFAM PEBP family protein
C0216_RS22310	COG1119	ATPase activity
C0216_RS22325	COG2197	response regulator
C0216_RS22330	COG4585	Histidine kinase
C0216_RS22340	COG0842	Transport permease protein
C0216_RS22340	COG1131	(ABC) transporter
C0216_RS22340	COG1716	ATPase activity
C0216_RS22345	COG0560	Phosphoserine phosphatase
C0216_RS22345	COG3830	Belongs to the UPF0237 family
C0216_RS22350	COG0588	phosphoglycerate mutase activity
C0216_RS22365	COG2186	Transcriptional regulator
C0216_RS22375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0216_RS22380	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS22395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0216_RS22415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0216_RS22420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0216_RS22450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0216_RS22465	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS22490	COG1302	Protein conserved in bacteria
C0216_RS22495	COG1024	Enoyl-CoA hydratase
C0216_RS22505	COG0488	(ABC) transporter
C0216_RS22535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C0216_RS22540	COG1492	cobalamin metabolic process
C0216_RS22555	COG1797	cobyrinic acid a,c-diamide synthase activity
C0216_RS22585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0216_RS22595	COG0768	penicillin binding
C0216_RS22600	COG2197	response regulator
C0216_RS22605	COG4585	Histidine kinase
C0216_RS22660	COG2171	N-acyltransferase activity
C0216_RS22675	COG2151	metal-sulfur cluster biosynthetic enzyme
C0216_RS22680	COG0822	iron-sulfur transferase activity
C0216_RS22685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0216_RS22690	COG0396	ATPase activity
C0216_RS22700	COG0719	Fe-S assembly protein
C0216_RS22715	COG1131	(ABC) transporter
C0216_RS22730	COG1612	heme a metabolic process
C0216_RS22740	COG0109	protoheme IX farnesyltransferase activity
C0216_RS22750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0216_RS22765	COG0363	glucosamine-6-phosphate deaminase activity
C0216_RS22770	COG0166	Belongs to the GPI family
C0216_RS22780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0216_RS22785	COG0149	triose-phosphate isomerase activity
C0216_RS22790	COG0126	phosphoglycerate kinase activity
C0216_RS22795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0216_RS22805	COG1481	regulation of sporulation
C0216_RS22815	COG1660	Displays ATPase and GTPase activities
C0216_RS22820	COG0322	excinuclease ABC activity
C0216_RS22850	COG0644	oxidoreductase
C0216_RS22855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0216_RS22865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0216_RS22870	COG0477	Major facilitator Superfamily
C0216_RS22890	COG0556	nucleotide-excision repair
C0216_RS22895	COG0584	glycerophosphoryl diester phosphodiesterase
C0216_RS22900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0216_RS22905	COG0477	Major facilitator Superfamily
C0216_RS22915	COG2313	pseudouridylate synthase activity
C0216_RS22955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0216_RS22970	COG0237	dephospho-CoA kinase activity
C0216_RS22980	COG0539	negative regulation of cytoplasmic translation
C0216_RS22985	COG2226	methyltransferase
C0216_RS22985	COG1073	alpha beta
C0216_RS22990	COG1643	Atp-dependent helicase
C0216_RS23025	COG2050	protein possibly involved in aromatic compounds catabolism
C0216_RS23040	COG0559	Belongs to the binding-protein-dependent transport system permease family
C0216_RS23090	COG0737	Belongs to the 5'-nucleotidase family
C0216_RS23120	COG1605	Chorismate mutase
C0216_RS23120	COG0287	Prephenate dehydrogenase
C0216_RS23140	COG1024	Enoyl-CoA hydratase
C0216_RS23165	COG0183	Belongs to the thiolase family
C0216_RS23170	COG1309	transcriptional regulator
C0216_RS23180	COG1960	acyl-CoA dehydrogenase activity
C0216_RS23190	COG2304	oxidoreductase activity
C0216_RS23210	COG0070	glutamate synthase
C0216_RS23210	COG0069	glutamate synthase activity
C0216_RS23210	COG0067	glutamate synthase
C0216_RS23220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0216_RS23225	COG2301	Belongs to the HpcH HpaI aldolase family
C0216_RS23230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0216_RS23240	COG0159	tryptophan synthase activity
C0216_RS23245	COG0133	tryptophan synthase activity
C0216_RS23255	COG0134	indole-3-glycerol-phosphate synthase activity
C0216_RS23280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0216_RS23290	COG0107	imidazoleglycerol-phosphate synthase activity
C0216_RS23295	COG0251	oxidation-reduction process
C0216_RS23300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0216_RS23305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0216_RS23310	COG0131	Imidazoleglycerol-phosphate dehydratase
C0216_RS23315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0216_RS23320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0216_RS23335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0216_RS23355	COG1432	Conserved Protein
C0216_RS23360	COG0587	DNA-directed DNA polymerase activity
C0216_RS23415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0216_RS23425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0216_RS23435	COG3599	regulation of cell shape
C0216_RS23445	COG1799	cell septum assembly
C0216_RS23460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0216_RS23465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0216_RS23470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0216_RS23480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0216_RS23485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0216_RS23495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0216_RS23515	COG0275	rRNA processing
C0216_RS23525	COG0714	Associated with various cellular activities
C0216_RS23540	COG1309	transcriptional regulator
C0216_RS23545	COG1511	domain protein
C0216_RS23560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0216_RS23575	COG1233	COG1233 Phytoene dehydrogenase and related
C0216_RS23590	COG0352	thiamine-phosphate diphosphorylase activity
C0216_RS23605	COG2022	thiamine diphosphate biosynthetic process
C0216_RS23605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0216_RS23615	COG2022	thiamine diphosphate biosynthetic process
C0216_RS23620	COG0515	serine threonine protein kinase
C0216_RS23620	COG2815	serine threonine protein kinase
C0216_RS23625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C0216_RS23630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0216_RS23635	COG2193	ferroxidase activity
C0216_RS23645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C0216_RS23655	COG0205	6-phosphofructokinase activity
C0216_RS23660	COG2197	response regulator
C0216_RS23665	COG4585	Histidine kinase
C0216_RS23690	COG1940	carbohydrate kinase activity
C0216_RS23700	COG0003	Pfam Anion-transporting ATPase
C0216_RS23735	COG0438	transferase activity, transferring glycosyl groups
C0216_RS23775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0216_RS23780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0216_RS23785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0216_RS23790	COG0723	plastoquinol--plastocyanin reductase activity
C0216_RS23795	COG2010	Cytochrome c
C0216_RS23800	COG1845	cytochrome c oxidase, subunit III
C0216_RS23810	COG1376	ErfK ybiS ycfS ynhG family protein
C0216_RS23820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0216_RS23825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0216_RS23835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0216_RS23855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0216_RS23860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0216_RS23865	COG2197	response regulator
C0216_RS23870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C0216_RS23895	COG2226	methyltransferase
C0216_RS23910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C0216_RS23915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0216_RS23915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0216_RS23920	COG4585	Histidine kinase
C0216_RS23950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0216_RS23955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0216_RS23960	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0216_RS23970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0216_RS23980	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS24015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0216_RS24020	COG0321	lipoyl(octanoyl) transferase activity
C0216_RS24060	COG2770	Histidine kinase
C0216_RS24060	COG2208	phosphoserine phosphatase activity
C0216_RS24085	COG0745	RESPONSE REGULATOR receiver
C0216_RS24105	COG2365	Tyrosine phosphatase family
C0216_RS24150	COG0366	Alpha amylase catalytic
C0216_RS24155	COG3833	ABC-type maltose transport systems, permease component
C0216_RS24160	COG1175	transmembrane transport
C0216_RS24170	COG0366	Alpha amylase catalytic
C0216_RS24175	COG1609	Transcriptional regulator
C0216_RS24270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0216_RS24285	COG2207	Transcriptional regulator
C0216_RS24285	COG3708	Transcriptional regulator
C0216_RS24305	COG3209	COG3209 Rhs family protein
C0216_RS24315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0216_RS24330	COG0174	glutamine synthetase
C0216_RS24370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0216_RS24370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0216_RS24380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0216_RS24400	COG1994	Peptidase M50
C0216_RS24425	COG5398	heme oxygenase
C0216_RS24445	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS24450	COG2814	Major facilitator Superfamily
C0216_RS24460	COG1834	amidinotransferase
C0216_RS24475	COG3022	response to hydroperoxide
C0216_RS24480	COG0557	exoribonuclease II activity
C0216_RS24510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0216_RS24520	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS24530	COG2030	dehydratase
C0216_RS24540	COG0183	Belongs to the thiolase family
C0216_RS24545	COG1960	acyl-CoA dehydrogenase activity
C0216_RS24570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0216_RS24590	COG0438	transferase activity, transferring glycosyl groups
C0216_RS24595	COG1309	transcriptional regulator
C0216_RS24615	COG1657	PFAM Prenyltransferase squalene oxidase
C0216_RS24630	COG3845	ABC transporter
C0216_RS24645	COG0183	Belongs to the thiolase family
C0216_RS24650	COG2124	cytochrome p450
C0216_RS24680	COG3415	Transposase
C0216_RS24680	COG2801	Transposase and inactivated derivatives
C0216_RS24720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0216_RS24790	COG1358	cellular component organization or biogenesis
C0216_RS24835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0216_RS24840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0216_RS24850	COG0477	Major facilitator Superfamily
C0216_RS24855	COG1309	transcriptional regulator
C0216_RS24870	COG0667	Aldo Keto reductase
C0216_RS24900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0216_RS24905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0216_RS24910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0216_RS24955	COG1733	regulation of RNA biosynthetic process
C0216_RS24970	COG1764	response to oxidative stress
C0216_RS24975	COG2130	NADP-dependent
C0216_RS24995	COG1077	Cell shape determining protein MreB Mrl
C0216_RS25000	COG1522	sequence-specific DNA binding
C0216_RS25010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0216_RS25010	COG0825	malonyl-CoA metabolic process
C0216_RS25015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C0216_RS25050	COG1070	Carbohydrate kinase
C0216_RS25070	COG0243	molybdopterin cofactor binding
C0216_RS25075	COG2949	membrane
C0216_RS25085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C0216_RS25095	COG0358	DNA primase activity
C0216_RS25120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0216_RS25125	COG2146	nitrite reductase [NAD(P)H] activity
C0216_RS25125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0216_RS25145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0216_RS25145	COG0574	Belongs to the PEP-utilizing enzyme family
C0216_RS25155	COG0667	Aldo Keto reductase
C0216_RS25160	COG1309	transcriptional regulator
C0216_RS25170	COG0423	glycine-tRNA ligase activity
C0216_RS25180	COG1121	(ABC) transporter
C0216_RS25185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0216_RS25195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0216_RS25200	COG1381	Involved in DNA repair and RecF pathway recombination
C0216_RS25215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0216_RS25240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0216_RS25260	COG2315	Protein conserved in bacteria
C0216_RS25270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0216_RS25280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0216_RS25285	COG1234	tRNA 3'-trailer cleavage
C0216_RS25290	COG0537	adenosine 5'-monophosphoramidase activity
C0216_RS25300	COG2070	2-Nitropropane dioxygenase
C0216_RS25305	COG0484	heat shock protein binding
C0216_RS25310	COG1420	regulation of RNA biosynthetic process
C0216_RS25330	COG1022	Amp-dependent synthetase and ligase
C0216_RS25335	COG0481	GTPase activity
C0216_RS25340	COG0268	Binds directly to 16S ribosomal RNA
C0216_RS25365	COG1555	photosystem II stabilization
C0216_RS25370	COG1307	EDD domain protein, DegV family
C0216_RS25380	COG0495	leucyl-tRNA aminoacylation
C0216_RS25400	COG0588	phosphoglycerate mutase activity
C0216_RS25405	COG0799	negative regulation of ribosome biogenesis
C0216_RS25415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0216_RS25420	COG0501	Belongs to the peptidase M48B family
C0216_RS25435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0216_RS25445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0216_RS25455	COG0463	Glycosyl transferase, family 2
C0216_RS25460	COG0463	Glycosyl transferase, family 2
C0216_RS25460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C0216_RS25465	COG0438	transferase activity, transferring glycosyl groups
C0216_RS25480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0216_RS25485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0216_RS25490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0216_RS25495	COG1530	ribonuclease E activity
C0216_RS25525	COG0772	Belongs to the SEDS family
C0216_RS25530	COG0768	penicillin binding
C0216_RS25545	COG1077	Cell shape determining protein MreB Mrl
C0216_RS25550	COG0105	UTP biosynthetic process
C0216_RS25560	COG0285	dihydrofolate synthase activity
C0216_RS25570	COG0525	valine-tRNA ligase activity
C0216_RS25580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0216_RS25585	COG0740	serine-type endopeptidase activity
C0216_RS25590	COG0740	serine-type endopeptidase activity
C0216_RS25595	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0216_RS25685	COG2188	Transcriptional regulator
C0216_RS25745	COG4552	Acetyltransferase involved in intracellular survival and related
C0216_RS25760	COG1113	amino acid transport
C0216_RS25770	COG1113	amino acid transport
C0216_RS25775	COG1113	amino acid transport
C0216_RS25780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0216_RS25785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0216_RS25830	COG0583	DNA-binding transcription factor activity
C0216_RS25835	COG0697	spore germination
C0216_RS25840	COG0697	spore germination
C0216_RS25870	COG2267	carboxylic ester hydrolase activity
C0216_RS25880	COG0668	transmembrane transport
C0216_RS25885	COG1940	carbohydrate kinase activity
C0216_RS25890	COG1486	melibiose metabolic process
C0216_RS25905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0216_RS25915	COG0515	serine threonine protein kinase
C0216_RS25935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0216_RS25940	COG2346	COG2346, Truncated hemoglobins
C0216_RS25970	COG0629	single-stranded DNA binding
C0216_RS25990	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS26005	COG2091	lysine biosynthetic process via aminoadipic acid
C0216_RS26010	COG0454	-acetyltransferase
C0216_RS26010	COG0456	acetyltransferase
C0216_RS26025	COG3962	Belongs to the TPP enzyme family
C0216_RS26030	COG3718	enzyme involved in inositol metabolism
C0216_RS26035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0216_RS26045	COG0673	inositol 2-dehydrogenase activity
C0216_RS26070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0216_RS26085	COG1472	Belongs to the glycosyl hydrolase 3 family
C0216_RS26115	COG2186	Transcriptional regulator
C0216_RS26160	COG1946	Acyl-CoA thioesterase
C0216_RS26170	COG1309	transcriptional regulator
C0216_RS26175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0216_RS26190	COG1960	acyl-CoA dehydrogenase activity
C0216_RS26205	COG0076	glutamate decarboxylase activity
C0216_RS26210	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C0216_RS26240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0216_RS26250	COG0589	response to stress
C0216_RS26260	COG4977	sequence-specific DNA binding
C0216_RS26265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0216_RS26310	COG0406	alpha-ribazole phosphatase activity
C0216_RS26375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0216_RS26445	COG0673	inositol 2-dehydrogenase activity
C0216_RS26460	COG0706	membrane insertase activity
C0216_RS26500	COG2733	membrane
C0216_RS26525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0216_RS26555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0216_RS26565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0216_RS26570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0216_RS26575	COG1263	PTS System
C0216_RS26580	COG1263	PTS System
C0216_RS26595	COG3189	MarR family transcriptional regulator
C0216_RS26625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0216_RS26635	COG1335	isochorismatase
C0216_RS26670	COG0277	FAD linked oxidase domain protein
C0216_RS26680	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C0216_RS26720	COG3654	unkown
C0216_RS26770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C0216_RS26780	COG1678	Uncharacterized ACR, COG1678
C0216_RS26785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0216_RS26790	COG0776	regulation of translation
C0216_RS26800	COG3973	AAA domain
C0216_RS26825	COG0583	DNA-binding transcription factor activity
C0216_RS26850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0216_RS26855	COG0793	Belongs to the peptidase S41A family
C0216_RS26865	COG2884	Cell division ATP-binding protein ftsE
C0216_RS26875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C0216_RS26885	COG0515	serine threonine protein kinase
C0216_RS26890	COG0515	serine threonine protein kinase
C0216_RS26905	COG1175	transmembrane transport
C0216_RS26910	COG0395	ABC-type sugar transport system, permease component
C0216_RS26915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C0216_RS26925	COG2902	Dehydrogenase
C0216_RS26945	COG0653	protein targeting
C0216_RS26960	COG2197	response regulator
C0216_RS26965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0216_RS26975	COG0823	Involved in the tonB-independent uptake of proteins
C0216_RS26980	COG5002	protein histidine kinase activity
C0216_RS26980	COG5000	phosphorelay sensor kinase activity
C0216_RS26985	COG0745	RESPONSE REGULATOR receiver
C0216_RS27005	COG0714	Associated with various cellular activities
C0216_RS27055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C0216_RS27065	COG1482	cell wall glycoprotein biosynthetic process
C0216_RS27075	COG2835	tetraacyldisaccharide 4'-kinase activity
C0216_RS27080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0216_RS27120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C0216_RS27125	COG0778	Nitroreductase
C0216_RS27125	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C0216_RS27145	COG1316	TRANSCRIPTIONal
C0216_RS27150	COG1316	TRANSCRIPTIONal
C0216_RS27170	COG1607	acyl-coa hydrolase
C0216_RS27175	COG1316	TRANSCRIPTIONal
C0216_RS27190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C0216_RS27220	COG2205	protein histidine kinase activity
C0216_RS27230	COG3104	oligopeptide transport
C0216_RS27255	COG1228	amidohydrolase
C0216_RS27270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0216_RS27290	COG2755	lipolytic protein G-D-S-L family
C0216_RS27295	COG0183	Belongs to the thiolase family
C0216_RS27325	COG1136	(ABC) transporter
C0216_RS27330	COG1136	(ABC) transporter
C0216_RS27330	COG0577	efflux transmembrane transporter activity
C0216_RS27335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0216_RS27365	COG0148	phosphopyruvate hydratase activity
C0216_RS27380	COG2124	cytochrome p450
C0216_RS27395	COG0515	serine threonine protein kinase
C0216_RS27395	COG2815	serine threonine protein kinase
C0216_RS27410	COG0577	efflux transmembrane transporter activity
C0216_RS27415	COG1136	(ABC) transporter
C0216_RS27420	COG0477	Major facilitator Superfamily
C0216_RS27455	COG4585	Histidine kinase
C0216_RS27470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0216_RS27475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0216_RS27480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0216_RS27485	COG0193	aminoacyl-tRNA hydrolase activity
C0216_RS27495	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C0216_RS27510	COG4106	trans-aconitate 2-methyltransferase activity
C0216_RS27515	COG1846	Transcriptional regulator
C0216_RS27520	COG2197	response regulator
C0216_RS27545	COG0488	(ABC) transporter
C0216_RS27550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0216_RS27555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0216_RS27565	COG0084	hydrolase, TatD family'
C0216_RS27585	COG0768	penicillin binding
C0216_RS27590	COG1309	transcriptional regulator
C0216_RS27600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C0216_RS27605	COG1122	ATPase activity
C0216_RS27615	COG0310	cobalt ion transport
C0216_RS27625	COG2409	Drug exporters of the RND superfamily
C0216_RS27635	COG0793	Belongs to the peptidase S41A family
C0216_RS27635	COG4946	Tricorn protease homolog
C0216_RS27640	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS27645	COG2267	carboxylic ester hydrolase activity
C0216_RS27650	COG2072	flavoprotein involved in K transport
C0216_RS27690	COG0477	Major facilitator Superfamily
C0216_RS27745	COG0315	cyclic pyranopterin monophosphate synthase activity
C0216_RS27745	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0216_RS27750	COG0315	cyclic pyranopterin monophosphate synthase activity
C0216_RS27760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0216_RS27765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0216_RS27790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C0216_RS27800	COG1970	mechanosensitive ion channel activity
C0216_RS27895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0216_RS27900	COG0438	transferase activity, transferring glycosyl groups
C0216_RS27900	COG0297	glycogen (starch) synthase activity
C0216_RS27960	COG0477	Major facilitator Superfamily
C0216_RS27975	COG3384	dioxygenase
C0216_RS28020	COG1686	Belongs to the peptidase S11 family
C0216_RS28040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0216_RS28080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0216_RS28085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C0216_RS28135	COG2816	NAD+ diphosphatase activity
C0216_RS28180	COG1024	Enoyl-CoA hydratase
C0216_RS28210	COG0515	serine threonine protein kinase
C0216_RS28210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0216_RS28220	COG1309	transcriptional regulator
C0216_RS28230	COG1960	acyl-CoA dehydrogenase activity
C0216_RS28255	COG2072	flavoprotein involved in K transport
C0216_RS28265	COG1024	Enoyl-CoA hydratase
C0216_RS28290	COG1960	acyl-CoA dehydrogenase activity
C0216_RS28295	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS28305	COG4585	Histidine kinase
C0216_RS28310	COG2197	response regulator
C0216_RS28320	COG1960	acyl-CoA dehydrogenase activity
C0216_RS28325	COG1960	acyl-CoA dehydrogenase activity
C0216_RS28335	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS28425	COG1131	(ABC) transporter
C0216_RS28435	COG2249	NAD(P)H dehydrogenase (quinone) activity
C0216_RS28440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0216_RS28450	COG4821	SIS domain
C0216_RS28460	COG0259	pyridoxamine-phosphate oxidase activity
C0216_RS28470	COG1309	transcriptional regulator
C0216_RS28490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0216_RS28515	COG0247	lactate metabolic process
C0216_RS28515	COG0277	FAD linked oxidase domain protein
C0216_RS28520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0216_RS28555	COG1733	regulation of RNA biosynthetic process
C0216_RS28560	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0216_RS28575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0216_RS28585	COG2252	PERMEase
C0216_RS28615	COG0667	Aldo Keto reductase
C0216_RS28655	COG2814	Major facilitator Superfamily
C0216_RS28665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0216_RS28670	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C0216_RS28675	COG1278	Cold shock
C0216_RS28685	COG0546	phosphoglycolate phosphatase activity
C0216_RS28715	COG1061	Type III restriction enzyme res subunit
C0216_RS28735	COG3973	AAA domain
C0216_RS28775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C0216_RS28780	COG1263	PTS System
C0216_RS28780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0216_RS28810	COG3896	Chloramphenicol phosphotransferase-like protein
C0216_RS28815	COG0135	phosphoribosylanthranilate isomerase activity
C0216_RS28850	COG0463	Glycosyl transferase, family 2
C0216_RS28855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C0216_RS28860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0216_RS28860	COG1877	trehalose-phosphatase activity
C0216_RS28870	COG2182	Extracellular solute-binding protein
C0216_RS28905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0216_RS28930	COG2197	response regulator
C0216_RS28940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0216_RS28940	COG0723	plastoquinol--plastocyanin reductase activity
C0216_RS28950	COG3842	ATPase activity
C0216_RS28970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0216_RS28975	COG0215	cysteine-tRNA ligase activity
C0216_RS28980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0216_RS28985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0216_RS28990	COG1329	Transcriptional regulator
C0216_RS29010	COG5002	protein histidine kinase activity
C0216_RS29050	COG0588	phosphoglycerate mutase activity
C0216_RS29055	COG2814	Major facilitator Superfamily
C0216_RS29055	COG0477	Major facilitator Superfamily
C0216_RS29065	COG0438	transferase activity, transferring glycosyl groups
C0216_RS29125	COG1733	regulation of RNA biosynthetic process
C0216_RS29140	COG2890	protein-(glutamine-N5) methyltransferase activity
C0216_RS29145	COG4552	Acetyltransferase involved in intracellular survival and related
C0216_RS29155	COG1490	D-aminoacyl-tRNA deacylase activity
C0216_RS29165	COG0735	belongs to the Fur family
C0216_RS29170	COG3485	protocatechuate 3,4-dioxygenase
C0216_RS29195	COG2897	thiosulfate sulfurtransferase activity
C0216_RS29215	COG0745	RESPONSE REGULATOR receiver
C0216_RS29220	COG1609	Transcriptional regulator
C0216_RS29225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0216_RS29230	COG0745	RESPONSE REGULATOR receiver
C0216_RS29240	COG0737	Belongs to the 5'-nucleotidase family
C0216_RS29245	COG0456	acetyltransferase
C0216_RS29250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C0216_RS29280	COG0306	phosphate transporter
C0216_RS29290	COG1937	Protein conserved in bacteria
C0216_RS29310	COG0671	phosphoesterase, PA-phosphatase related
C0216_RS29315	COG0739	heme binding
C0216_RS29315	COG1196	nuclear chromosome segregation
C0216_RS29315	COG0741	lytic transglycosylase activity
C0216_RS29330	COG1357	PFAM Pentapeptide repeats (8 copies)
C0216_RS29390	COG4221	oxidoreductase activity
C0216_RS29445	COG1252	NADH dehydrogenase
C0216_RS29470	COG0579	oxidoreductase
C0216_RS29475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0216_RS29485	COG1196	nuclear chromosome segregation
C0216_RS29485	COG0739	heme binding
C0216_RS29485	COG0741	lytic transglycosylase activity
C0216_RS29500	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0216_RS29540	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C0216_RS29560	COG2022	thiamine diphosphate biosynthetic process
C0216_RS29560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0216_RS29565	COG1045	serine acetyltransferase
C0216_RS29570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0216_RS29570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0216_RS29595	COG0513	Belongs to the DEAD box helicase family
C0216_RS29605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0216_RS29610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0216_RS29635	COG0785	Cytochrome C biogenesis protein
C0216_RS29640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0216_RS29650	COG1643	Atp-dependent helicase
C0216_RS29680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0216_RS29700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0216_RS29705	COG0047	phosphoribosylformylglycinamidine synthase activity
C0216_RS29710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0216_RS29735	COG2197	response regulator
C0216_RS29745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0216_RS29760	COG0151	Belongs to the GarS family
C0216_RS29845	COG0433	COG0433 Predicted ATPase
C0216_RS29860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0216_RS29905	COG1191	sigma factor activity
C0216_RS29920	COG0477	Major facilitator Superfamily
C0216_RS29925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0216_RS29935	COG2205	protein histidine kinase activity
C0216_RS29940	COG0745	RESPONSE REGULATOR receiver
C0216_RS29990	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS29995	COG1595	DNA-templated transcription, initiation
C0216_RS30020	COG1960	acyl-CoA dehydrogenase activity
C0216_RS30045	COG2855	membrane
C0216_RS30055	COG0583	DNA-binding transcription factor activity
C0216_RS30060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0216_RS30075	COG0653	protein targeting
C0216_RS30095	COG0006	proline dipeptidase activity
C0216_RS30115	COG1999	signal sequence binding
C0216_RS30125	COG2372	response to copper ion
C0216_RS30130	COG2837	iron assimilation
C0216_RS30140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0216_RS30145	COG0561	phosphatase activity
C0216_RS30180	COG0789	Transcriptional regulator
C0216_RS30190	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C0216_RS30195	COG0326	Molecular chaperone. Has ATPase activity
C0216_RS30250	COG0561	phosphatase activity
C0216_RS30255	COG4988	ABC transporter
C0216_RS30260	COG1294	oxidase, subunit
C0216_RS30265	COG1271	oxidase subunit
C0216_RS30275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0216_RS30280	COG1609	Transcriptional regulator
C0216_RS30330	COG0641	radical SAM
C0216_RS30350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0216_RS30375	COG0662	Cupin 2, conserved barrel domain protein
C0216_RS30380	COG1950	PFAM Membrane protein of
C0216_RS30385	COG0626	cystathionine gamma-synthase activity
C0216_RS30425	COG0305	Participates in initiation and elongation during chromosome replication
C0216_RS30435	COG0359	binds to the 23S rRNA
C0216_RS30440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0216_RS30445	COG0629	single-stranded DNA binding
C0216_RS30450	COG0360	Binds together with S18 to 16S ribosomal RNA
C0216_RS30475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0216_RS30515	COG1595	DNA-templated transcription, initiation
C0216_RS30525	COG0492	ferredoxin-NADP+ reductase activity
C0216_RS30530	COG3118	belongs to the thioredoxin family
C0216_RS30545	COG1192	Involved in chromosome partitioning
C0216_RS30550	COG0357	Ribosomal RNA small subunit methyltransferase G
C0216_RS30560	COG0706	membrane insertase activity
C0216_RS30565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0216_RS30570	COG0594	ribonuclease P activity
C0216_RS30575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C0216_RS30760	COG1475	DNA binding
C0216_RS30765	COG1192	Involved in chromosome partitioning
C0216_RS30795	COG1660	Displays ATPase and GTPase activities
C0216_RS30970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0216_RS30985	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C0216_RS31045	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C0216_RS31255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0216_RS31265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0216_RS31270	COG0590	tRNA wobble adenosine to inosine editing
C0216_RS31275	COG2076	Multidrug Resistance protein
C0216_RS31300	COG0662	Cupin 2, conserved barrel domain protein
C0216_RS31305	COG1960	acyl-CoA dehydrogenase activity
C0216_RS31335	COG1091	dTDP-4-dehydrorhamnose reductase activity
C0216_RS31370	COG3321	synthase
C0216_RS31370	COG0604	alcohol dehydrogenase
C0216_RS31380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0216_RS31380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0216_RS31380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS31380	COG3321	synthase
C0216_RS31380	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS31385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS31385	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS31385	COG3321	synthase
C0216_RS31385	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS31385	COG0300	oxidoreductase activity
C0216_RS31390	COG3321	synthase
C0216_RS31390	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS31390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS31390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0216_RS31390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0216_RS31390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0216_RS31390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0216_RS31390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS31390	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS31390	COG3321	synthase
C0216_RS31395	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS31395	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS31395	COG3321	synthase
C0216_RS31395	COG0300	oxidoreductase activity
C0216_RS31395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS31425	COG0477	Major facilitator Superfamily
C0216_RS31445	COG2226	methyltransferase
C0216_RS31450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C0216_RS31460	COG2124	cytochrome p450
C0216_RS31465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0216_RS31465	COG2070	2-Nitropropane dioxygenase
C0216_RS31470	COG2226	methyltransferase
C0216_RS31470	COG2867	negative regulation of translational initiation
C0216_RS31500	COG3693	PFAM glycoside hydrolase, family 10
C0216_RS31520	COG1476	TRANSCRIPTIONal
C0216_RS31540	COG1132	(ABC) transporter
C0216_RS31555	COG0596	Alpha beta hydrolase
C0216_RS31585	COG1131	(ABC) transporter
C0216_RS31620	COG2255	four-way junction helicase activity
C0216_RS31625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0216_RS31655	COG3251	PFAM MbtH domain protein
C0216_RS31685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0216_RS31695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS31745	COG1475	DNA binding
C0216_RS31750	COG1192	Involved in chromosome partitioning
C0216_RS31770	COG0702	epimerase
C0216_RS31780	COG1280	lysine exporter protein (LysE YggA)
C0216_RS31795	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS31800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0216_RS31825	COG0702	epimerase
C0216_RS31835	COG1309	transcriptional regulator
C0216_RS31855	COG0300	oxidoreductase activity
C0216_RS31855	COG4221	oxidoreductase activity
C0216_RS31855	COG3321	synthase
C0216_RS31855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0216_RS31860	COG3629	intracellular signal transduction
C0216_RS31875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0216_RS31880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0216_RS31895	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS31965	COG1518	maintenance of DNA repeat elements
C0216_RS32000	COG0477	Major facilitator Superfamily
C0216_RS32015	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C0216_RS32015	COG0493	'glutamate synthase
C0216_RS32030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0216_RS32030	COG2070	2-Nitropropane dioxygenase
C0216_RS32040	COG0604	alcohol dehydrogenase
C0216_RS32040	COG3321	synthase
C0216_RS32050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0216_RS32065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0216_RS32095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0216_RS32120	COG0741	lytic transglycosylase activity
C0216_RS32120	COG0739	heme binding
C0216_RS32120	COG1196	nuclear chromosome segregation
C0216_RS32130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0216_RS32140	COG0318	PFAM AMP-dependent synthetase and ligase
C0216_RS32145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0216_RS32150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0216_RS32155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0216_RS32265	COG1518	maintenance of DNA repeat elements
C0216_RS32280	COG1857	crispr-associated protein
C0216_RS32320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0216_RS32355	COG0546	phosphoglycolate phosphatase activity
C0216_RS32390	COG0326	Molecular chaperone. Has ATPase activity
C0216_RS32425	COG0662	Cupin 2, conserved barrel domain protein
C0216_RS32450	COG1073	alpha beta
C0216_RS32450	COG2226	methyltransferase
C0216_RS32545	COG1024	Enoyl-CoA hydratase
C0216_RS32550	COG1024	Enoyl-CoA hydratase
C0216_RS32555	COG3424	synthase
C0216_RS32560	COG1834	amidinotransferase
C0216_RS32580	COG1686	Belongs to the peptidase S11 family
C0216_RS32685	COG3903	Transcriptional regulator
C0216_RS32685	COG3629	intracellular signal transduction
C0216_RS32690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0216_RS32740	COG3173	Aminoglycoside phosphotransferase
C0216_RS32760	COG0151	Belongs to the GarS family
C0216_RS32765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0216_RS32770	COG0673	inositol 2-dehydrogenase activity
C0216_RS32780	COG2175	clavaminate synthase activity
C0216_RS32820	COG1132	(ABC) transporter
C0216_RS32825	COG1132	(ABC) transporter
C0216_RS32830	COG0477	Major facilitator Superfamily
C0216_RS32860	COG1113	amino acid transport
C0216_RS32875	COG2815	serine threonine protein kinase
C0216_RS32875	COG0515	serine threonine protein kinase
C0216_RS32880	COG0702	epimerase
C0216_RS32885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0216_RS32930	COG1028	Short-chain dehydrogenase reductase Sdr
C0216_RS32940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0216_RS32945	COG0583	DNA-binding transcription factor activity
C0216_RS32955	COG1278	Cold shock
C0216_RS32975	COG0697	spore germination
C0216_RS32980	COG0583	DNA-binding transcription factor activity
C0216_RS33040	COG2801	Transposase and inactivated derivatives
C0216_RS33245	COG3209	COG3209 Rhs family protein
C0216_RS33245	COG4104	PAAR repeat-containing protein