locus-tag	class	description
IGS71_RS00085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS71_RS00185	COG0789	Transcriptional regulator
IGS71_RS00205	COG0583	DNA-binding transcription factor activity
IGS71_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS00220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IGS71_RS00225	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS00230	COG1129	ABC transporter
IGS71_RS00240	COG1069	ribulokinase activity
IGS71_RS00245	COG1063	alcohol dehydrogenase
IGS71_RS00250	COG1879	ABC-type sugar transport system periplasmic component
IGS71_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS00320	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS00325	COG2188	Transcriptional regulator
IGS71_RS00345	COG1522	sequence-specific DNA binding
IGS71_RS00380	COG1309	transcriptional regulator
IGS71_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS00480	COG1819	glycosyl
IGS71_RS00520	COG0583	DNA-binding transcription factor activity
IGS71_RS00535	COG0583	DNA-binding transcription factor activity
IGS71_RS00540	COG2814	Major facilitator Superfamily
IGS71_RS00565	COG1136	(ABC) transporter
IGS71_RS00580	COG0300	oxidoreductase activity
IGS71_RS00585	COG1309	transcriptional regulator
IGS71_RS00590	COG3321	synthase
IGS71_RS00590	COG0604	alcohol dehydrogenase
IGS71_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS00610	COG0385	Bile acid
IGS71_RS00620	COG0726	polysaccharide deacetylase
IGS71_RS00625	COG0477	Major facilitator Superfamily
IGS71_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS00655	COG1940	carbohydrate kinase activity
IGS71_RS00670	COG0395	ABC-type sugar transport system, permease component
IGS71_RS00685	COG3903	Transcriptional regulator
IGS71_RS00685	COG3629	intracellular signal transduction
IGS71_RS00705	COG1309	transcriptional regulator
IGS71_RS00765	COG0601	transmembrane transport
IGS71_RS00770	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS00775	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS00795	COG4948	Mandelate Racemase Muconate Lactonizing
IGS71_RS00810	COG4221	oxidoreductase activity
IGS71_RS00820	COG0477	Major facilitator Superfamily
IGS71_RS00850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IGS71_RS00855	COG0475	glutathione-regulated potassium exporter activity
IGS71_RS00925	COG1695	Transcriptional regulator
IGS71_RS00945	COG2188	Transcriptional regulator
IGS71_RS00955	COG2222	sugar isomerase
IGS71_RS00980	COG4977	sequence-specific DNA binding
IGS71_RS00985	COG1461	Dihydroxyacetone kinase
IGS71_RS00990	COG2376	Dihydroxyacetone kinase
IGS71_RS00995	COG0477	Major facilitator Superfamily
IGS71_RS01005	COG1802	Transcriptional regulator
IGS71_RS01015	COG2197	response regulator
IGS71_RS01070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS01075	COG3321	synthase
IGS71_RS01075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS01075	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS01075	COG0300	oxidoreductase activity
IGS71_RS01080	COG2175	clavaminate synthase activity
IGS71_RS01090	COG0745	RESPONSE REGULATOR receiver
IGS71_RS01095	COG2205	protein histidine kinase activity
IGS71_RS01125	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS01145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS01190	COG0300	oxidoreductase activity
IGS71_RS01215	COG0395	ABC-type sugar transport system, permease component
IGS71_RS01220	COG1175	transmembrane transport
IGS71_RS01235	COG3250	beta-galactosidase activity
IGS71_RS01240	COG1609	Transcriptional regulator
IGS71_RS01250	COG1175	transmembrane transport
IGS71_RS01255	COG0395	ABC-type sugar transport system, permease component
IGS71_RS01260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS71_RS01280	COG0640	Transcriptional regulator
IGS71_RS01290	COG1063	alcohol dehydrogenase
IGS71_RS01300	COG1309	transcriptional regulator
IGS71_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS01330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS01345	COG2409	Drug exporters of the RND superfamily
IGS71_RS01365	COG1609	Transcriptional regulator
IGS71_RS01385	COG1175	transmembrane transport
IGS71_RS01390	COG0395	ABC-type sugar transport system, permease component
IGS71_RS01415	COG1309	transcriptional regulator
IGS71_RS01425	COG2084	Dehydrogenase
IGS71_RS01430	COG1082	Xylose isomerase domain protein TIM barrel
IGS71_RS01435	COG0149	triose-phosphate isomerase activity
IGS71_RS01440	COG0698	ribose 5-phosphate isomerase
IGS71_RS01445	COG2376	Dihydroxyacetone kinase
IGS71_RS01455	COG2186	Transcriptional regulator
IGS71_RS01465	COG0366	Alpha amylase catalytic
IGS71_RS01470	COG0395	ABC-type sugar transport system, permease component
IGS71_RS01475	COG1175	transmembrane transport
IGS71_RS01480	COG1653	transport
IGS71_RS01505	COG3246	L-lysine catabolic process to acetate
IGS71_RS01515	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS71_RS01520	COG1177	transmembrane transport
IGS71_RS01545	COG1454	alcohol dehydrogenase
IGS71_RS01555	COG2197	response regulator
IGS71_RS01605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS71_RS01655	COG1819	glycosyl
IGS71_RS01690	COG0515	serine threonine protein kinase
IGS71_RS01690	COG2815	serine threonine protein kinase
IGS71_RS01705	COG0477	Major facilitator Superfamily
IGS71_RS01730	COG0515	serine threonine protein kinase
IGS71_RS01745	COG3629	intracellular signal transduction
IGS71_RS01745	COG3903	Transcriptional regulator
IGS71_RS01750	COG0492	ferredoxin-NADP+ reductase activity
IGS71_RS01755	COG0667	Aldo Keto reductase
IGS71_RS01810	COG0791	NLP P60 protein
IGS71_RS01905	COG0596	Alpha beta hydrolase
IGS71_RS01910	COG1802	Transcriptional regulator
IGS71_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS01930	COG1228	amidohydrolase
IGS71_RS01935	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS01940	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS01945	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS01955	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS01985	COG0346	lactoylglutathione lyase activity
IGS71_RS01990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IGS71_RS01995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS02055	COG0583	DNA-binding transcription factor activity
IGS71_RS02060	COG1309	transcriptional regulator
IGS71_RS02070	COG1024	Enoyl-CoA hydratase
IGS71_RS02075	COG2197	response regulator
IGS71_RS02080	COG4585	Histidine kinase
IGS71_RS02085	COG1316	TRANSCRIPTIONal
IGS71_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS02100	COG0477	Major facilitator Superfamily
IGS71_RS02110	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS71_RS02120	COG0473	3-isopropylmalate dehydrogenase activity
IGS71_RS02125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS71_RS02165	COG0745	RESPONSE REGULATOR receiver
IGS71_RS02170	COG2409	Drug exporters of the RND superfamily
IGS71_RS02200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS02215	COG0596	Alpha beta hydrolase
IGS71_RS02220	COG1742	UPF0060 membrane protein
IGS71_RS02230	COG1252	NADH dehydrogenase
IGS71_RS02245	COG0431	NADPH-dependent FMN reductase
IGS71_RS02255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS02260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS02270	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS02275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS02320	COG1335	isochorismatase
IGS71_RS02350	COG1120	ATPase activity
IGS71_RS02355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS02365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS02390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS02465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IGS71_RS02475	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS71_RS02490	COG1595	DNA-templated transcription, initiation
IGS71_RS02505	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IGS71_RS02520	COG0745	RESPONSE REGULATOR receiver
IGS71_RS02525	COG0642	Histidine kinase
IGS71_RS02540	COG1609	Transcriptional regulator
IGS71_RS02550	COG1175	transmembrane transport
IGS71_RS02555	COG0395	ABC-type sugar transport system, permease component
IGS71_RS02570	COG1231	oxidoreductase activity
IGS71_RS02580	COG2814	Major facilitator Superfamily
IGS71_RS02620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IGS71_RS02640	COG3507	Belongs to the glycosyl hydrolase 43 family
IGS71_RS02645	COG1733	regulation of RNA biosynthetic process
IGS71_RS02655	COG3973	AAA domain
IGS71_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS02675	COG0659	secondary active sulfate transmembrane transporter activity
IGS71_RS02680	COG0395	ABC-type sugar transport system, permease component
IGS71_RS02685	COG1175	transmembrane transport
IGS71_RS02700	COG2186	Transcriptional regulator
IGS71_RS02710	COG3835	regulator
IGS71_RS02740	COG0725	ABC transporter, periplasmic molybdate-binding protein
IGS71_RS02765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGS71_RS02770	COG3250	beta-galactosidase activity
IGS71_RS02780	COG0739	heme binding
IGS71_RS02785	COG1733	regulation of RNA biosynthetic process
IGS71_RS02795	COG0137	argininosuccinate synthase activity
IGS71_RS02815	COG5002	protein histidine kinase activity
IGS71_RS02820	COG0745	RESPONSE REGULATOR receiver
IGS71_RS02855	COG2226	methyltransferase
IGS71_RS02875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS71_RS02885	COG3321	synthase
IGS71_RS02885	COG0604	alcohol dehydrogenase
IGS71_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS02905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS71_RS02910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IGS71_RS02915	COG2080	2 iron, 2 sulfur cluster binding
IGS71_RS02950	COG3540	Alkaline phosphatase
IGS71_RS02985	COG0181	hydroxymethylbilane synthase activity
IGS71_RS03005	COG2353	YceI-like domain
IGS71_RS03050	COG0513	Belongs to the DEAD box helicase family
IGS71_RS03055	COG1278	Cold shock
IGS71_RS03060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGS71_RS03075	COG2508	Transcriptional regulator
IGS71_RS03115	COG1191	sigma factor activity
IGS71_RS03130	COG0310	cobalt ion transport
IGS71_RS03135	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IGS71_RS03145	COG1122	ATPase activity
IGS71_RS03190	COG3290	protein histidine kinase activity
IGS71_RS03210	COG0673	inositol 2-dehydrogenase activity
IGS71_RS03225	COG0009	L-threonylcarbamoyladenylate synthase
IGS71_RS03235	COG0494	nUDIX hydrolase
IGS71_RS03255	COG0402	S-adenosylhomocysteine deaminase activity
IGS71_RS03275	COG0395	ABC-type sugar transport system, permease component
IGS71_RS03325	COG3537	Alpha-1,2-mannosidase
IGS71_RS03350	COG2197	response regulator
IGS71_RS03400	COG3250	beta-galactosidase activity
IGS71_RS03410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS71_RS03420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS71_RS03425	COG4948	Mandelate Racemase Muconate Lactonizing
IGS71_RS03440	COG0747	negative chemotaxis
IGS71_RS03445	COG0601	transmembrane transport
IGS71_RS03450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS03485	COG0596	Alpha beta hydrolase
IGS71_RS03520	COG0328	RNA-DNA hybrid ribonuclease activity
IGS71_RS03590	COG1819	glycosyl
IGS71_RS03600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS71_RS03605	COG2409	Drug exporters of the RND superfamily
IGS71_RS03610	COG4585	Histidine kinase
IGS71_RS03615	COG2197	response regulator
IGS71_RS03635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IGS71_RS03635	COG3608	succinylglutamate desuccinylase aspartoacylase
IGS71_RS03650	COG0515	serine threonine protein kinase
IGS71_RS03660	COG1132	(ABC) transporter
IGS71_RS03670	COG2197	response regulator
IGS71_RS03720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS03725	COG0747	negative chemotaxis
IGS71_RS03770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGS71_RS03790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS71_RS03830	COG0435	Glutathione S-transferase
IGS71_RS03865	COG4977	sequence-specific DNA binding
IGS71_RS03880	COG1414	Transcriptional regulator
IGS71_RS03890	COG0129	dihydroxy-acid dehydratase activity
IGS71_RS03895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS03900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS03910	COG0596	Alpha beta hydrolase
IGS71_RS03915	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS71_RS03915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS71_RS03975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IGS71_RS03975	COG1796	DNA polymerase
IGS71_RS03990	COG0583	DNA-binding transcription factor activity
IGS71_RS03995	COG0483	inositol monophosphate 1-phosphatase activity
IGS71_RS04005	COG1940	carbohydrate kinase activity
IGS71_RS04005	COG1846	Transcriptional regulator
IGS71_RS04015	COG1175	transmembrane transport
IGS71_RS04020	COG0395	ABC-type sugar transport system, permease component
IGS71_RS04025	COG2723	6-phospho-beta-galactosidase activity
IGS71_RS04060	COG1357	PFAM Pentapeptide repeats (8 copies)
IGS71_RS04075	COG1609	Transcriptional regulator
IGS71_RS04090	COG1879	ABC-type sugar transport system periplasmic component
IGS71_RS04095	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS04105	COG1129	ABC transporter
IGS71_RS04110	COG4952	isomerase
IGS71_RS04115	COG3347	Dehydrogenase
IGS71_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS04120	COG1070	Carbohydrate kinase
IGS71_RS04125	COG0247	lactate metabolic process
IGS71_RS04130	COG1139	Iron-sulfur cluster binding protein
IGS71_RS04135	COG1556	Lactate utilization protein
IGS71_RS04140	COG1125	glycine betaine transport
IGS71_RS04140	COG0517	IMP dehydrogenase activity
IGS71_RS04150	COG1174	glycine betaine transport
IGS71_RS04155	COG1174	glycine betaine transport
IGS71_RS04165	COG1562	ergosterol biosynthetic process
IGS71_RS04185	COG0242	peptide deformylase activity
IGS71_RS04195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS71_RS04200	COG1609	Transcriptional regulator
IGS71_RS04225	COG2268	Band 7 protein
IGS71_RS04240	COG3572	ergothioneine biosynthetic process
IGS71_RS04245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IGS71_RS04250	COG0121	glutamine amidotransferase
IGS71_RS04255	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IGS71_RS04260	COG3360	Dodecin
IGS71_RS04270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS04285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IGS71_RS04290	COG1053	succinate dehydrogenase
IGS71_RS04345	COG0726	polysaccharide deacetylase
IGS71_RS04375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS71_RS04400	COG0395	ABC-type sugar transport system, permease component
IGS71_RS04405	COG1175	transmembrane transport
IGS71_RS04455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS71_RS04460	COG0297	glycogen (starch) synthase activity
IGS71_RS04480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IGS71_RS04490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IGS71_RS04500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS71_RS04510	COG4221	oxidoreductase activity
IGS71_RS04555	COG1136	(ABC) transporter
IGS71_RS04560	COG0577	efflux transmembrane transporter activity
IGS71_RS04565	COG0577	efflux transmembrane transporter activity
IGS71_RS04570	COG1132	(ABC) transporter
IGS71_RS04580	COG0668	transmembrane transport
IGS71_RS04585	COG2814	Major facilitator Superfamily
IGS71_RS04600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS71_RS04605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS71_RS04610	COG2186	Transcriptional regulator
IGS71_RS04625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS71_RS04630	COG0745	RESPONSE REGULATOR receiver
IGS71_RS04665	COG2205	protein histidine kinase activity
IGS71_RS04675	COG5006	permease, DMT superfamily
IGS71_RS04685	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS04700	COG1879	ABC-type sugar transport system periplasmic component
IGS71_RS04705	COG1609	Transcriptional regulator
IGS71_RS04720	COG1309	transcriptional regulator
IGS71_RS04725	COG3473	Maleate cis-trans isomerase
IGS71_RS04770	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IGS71_RS04775	COG2130	NADP-dependent
IGS71_RS04820	COG1174	glycine betaine transport
IGS71_RS04825	COG1174	glycine betaine transport
IGS71_RS04840	COG2986	histidine ammonia-lyase
IGS71_RS04860	COG3284	Transcriptional regulator
IGS71_RS04865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS71_RS04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS04880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS04885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS04900	COG2197	response regulator
IGS71_RS04910	COG1136	(ABC) transporter
IGS71_RS04910	COG0577	efflux transmembrane transporter activity
IGS71_RS04920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IGS71_RS04930	COG1175	transmembrane transport
IGS71_RS04935	COG0395	ABC-type sugar transport system, permease component
IGS71_RS04940	COG1486	melibiose metabolic process
IGS71_RS04950	COG0739	heme binding
IGS71_RS04955	COG0028	Belongs to the TPP enzyme family
IGS71_RS04965	COG3387	PFAM Glycoside hydrolase 15-related
IGS71_RS04970	COG0277	FAD linked oxidase domain protein
IGS71_RS04970	COG0247	lactate metabolic process
IGS71_RS04980	COG0300	oxidoreductase activity
IGS71_RS05060	COG3629	intracellular signal transduction
IGS71_RS05060	COG3903	Transcriptional regulator
IGS71_RS05070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGS71_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS05125	COG0402	S-adenosylhomocysteine deaminase activity
IGS71_RS05130	COG0022	dehydrogenase e1 component
IGS71_RS05135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGS71_RS05140	COG0006	proline dipeptidase activity
IGS71_RS05170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS05175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS05180	COG1120	ATPase activity
IGS71_RS05190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IGS71_RS05195	COG1132	(ABC) transporter
IGS71_RS05200	COG1132	(ABC) transporter
IGS71_RS05205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IGS71_RS05220	COG3321	synthase
IGS71_RS05220	COG0604	alcohol dehydrogenase
IGS71_RS05235	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IGS71_RS05300	COG0604	alcohol dehydrogenase
IGS71_RS05300	COG3321	synthase
IGS71_RS05305	COG3321	synthase
IGS71_RS05305	COG0604	alcohol dehydrogenase
IGS71_RS05310	COG3321	synthase
IGS71_RS05310	COG0604	alcohol dehydrogenase
IGS71_RS05345	COG0596	Alpha beta hydrolase
IGS71_RS05350	COG3321	synthase
IGS71_RS05350	COG0604	alcohol dehydrogenase
IGS71_RS05360	COG1902	pentaerythritol trinitrate reductase activity
IGS71_RS05370	COG4221	oxidoreductase activity
IGS71_RS05370	COG0604	alcohol dehydrogenase
IGS71_RS05370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS05370	COG3321	synthase
IGS71_RS05420	COG0583	DNA-binding transcription factor activity
IGS71_RS05430	COG1063	alcohol dehydrogenase
IGS71_RS05465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IGS71_RS05475	COG2755	lipolytic protein G-D-S-L family
IGS71_RS05480	COG0739	heme binding
IGS71_RS05490	COG2365	Tyrosine phosphatase family
IGS71_RS05515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGS71_RS05530	COG1657	PFAM Prenyltransferase squalene oxidase
IGS71_RS05540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IGS71_RS05550	COG1562	ergosterol biosynthetic process
IGS71_RS05555	COG1134	teichoic acid transport
IGS71_RS05595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IGS71_RS05610	COG1024	Enoyl-CoA hydratase
IGS71_RS05620	COG4977	sequence-specific DNA binding
IGS71_RS05635	COG2183	response to ionizing radiation
IGS71_RS05640	COG0488	(ABC) transporter
IGS71_RS05650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IGS71_RS05660	COG2936	dipeptidyl-peptidase activity
IGS71_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS05680	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS05690	COG1129	ABC transporter
IGS71_RS05695	COG1414	Transcriptional regulator
IGS71_RS05705	COG1024	Enoyl-CoA hydratase
IGS71_RS05705	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS71_RS05710	COG0183	Belongs to the thiolase family
IGS71_RS05715	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS05720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS71_RS05725	COG3268	Saccharopine dehydrogenase
IGS71_RS05730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS05740	COG1515	deoxyribonuclease V activity
IGS71_RS05760	COG0488	(ABC) transporter
IGS71_RS05765	COG1834	amidinotransferase
IGS71_RS05820	COG1793	dna ligase
IGS71_RS05830	COG1846	Transcriptional regulator
IGS71_RS05845	COG0183	Belongs to the thiolase family
IGS71_RS05850	COG3485	protocatechuate 3,4-dioxygenase
IGS71_RS05855	COG3485	protocatechuate 3,4-dioxygenase
IGS71_RS05860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS71_RS05865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGS71_RS05900	COG3511	phospholipase C
IGS71_RS05910	COG0577	efflux transmembrane transporter activity
IGS71_RS05910	COG1136	(ABC) transporter
IGS71_RS05915	COG0577	efflux transmembrane transporter activity
IGS71_RS05915	COG1136	(ABC) transporter
IGS71_RS05925	COG2197	response regulator
IGS71_RS05930	COG4585	Histidine kinase
IGS71_RS05940	COG2197	response regulator
IGS71_RS05950	COG2409	Drug exporters of the RND superfamily
IGS71_RS05960	COG2205	protein histidine kinase activity
IGS71_RS05965	COG0745	RESPONSE REGULATOR receiver
IGS71_RS05990	COG1309	transcriptional regulator
IGS71_RS06020	COG1414	Transcriptional regulator
IGS71_RS06030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS06035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS06040	COG1116	anion transmembrane transporter activity
IGS71_RS06075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IGS71_RS06095	COG1486	melibiose metabolic process
IGS71_RS06105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS06115	COG1175	transmembrane transport
IGS71_RS06120	COG0395	ABC-type sugar transport system, permease component
IGS71_RS06125	COG3250	beta-galactosidase activity
IGS71_RS06155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS71_RS06170	COG0166	Belongs to the GPI family
IGS71_RS06175	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGS71_RS06180	COG0588	phosphoglycerate mutase activity
IGS71_RS06185	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IGS71_RS06185	COG1082	Xylose isomerase domain protein TIM barrel
IGS71_RS06190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS71_RS06200	COG0477	Major facilitator Superfamily
IGS71_RS06215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS71_RS06230	COG0297	glycogen (starch) synthase activity
IGS71_RS06250	COG0477	Major facilitator Superfamily
IGS71_RS06260	COG4585	Histidine kinase
IGS71_RS06270	COG1278	Cold shock
IGS71_RS06285	COG1316	TRANSCRIPTIONal
IGS71_RS06295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS71_RS06305	COG0515	serine threonine protein kinase
IGS71_RS06340	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IGS71_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS71_RS06355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGS71_RS06365	COG0535	radical SAM domain protein
IGS71_RS06370	COG0535	radical SAM domain protein
IGS71_RS06375	COG1971	Probably functions as a manganese efflux pump
IGS71_RS06380	COG3284	Transcriptional regulator
IGS71_RS06390	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS06400	COG0045	succinate-CoA ligase (ADP-forming) activity
IGS71_RS06410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS71_RS06420	COG2223	nitrite transmembrane transporter activity
IGS71_RS06455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IGS71_RS06475	COG0673	inositol 2-dehydrogenase activity
IGS71_RS06480	COG1879	ABC-type sugar transport system periplasmic component
IGS71_RS06485	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS06490	COG1129	ABC transporter
IGS71_RS06495	COG1940	carbohydrate kinase activity
IGS71_RS06505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS06520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGS71_RS06525	COG3383	formate dehydrogenase (NAD+) activity
IGS71_RS06540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IGS71_RS06560	COG0583	DNA-binding transcription factor activity
IGS71_RS06575	COG4221	oxidoreductase activity
IGS71_RS06580	COG0656	L-ascorbic acid biosynthetic process
IGS71_RS06590	COG4106	trans-aconitate 2-methyltransferase activity
IGS71_RS06595	COG5297	Belongs to the glycosyl hydrolase family 6
IGS71_RS06600	COG5297	Belongs to the glycosyl hydrolase family 6
IGS71_RS06600	COG4733	cellulase activity
IGS71_RS06605	COG3401	FG-GAP repeat protein
IGS71_RS06610	COG2226	methyltransferase
IGS71_RS06615	COG2154	pterin-4-alpha-carbinolamine dehydratase
IGS71_RS06625	COG0443	Heat shock 70 kDa protein
IGS71_RS06640	COG2255	four-way junction helicase activity
IGS71_RS06690	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IGS71_RS06695	COG0693	protein deglycase activity
IGS71_RS06705	COG0488	(ABC) transporter
IGS71_RS06710	COG1597	lipid kinase activity
IGS71_RS06715	COG2226	methyltransferase
IGS71_RS06780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS06785	COG1309	transcriptional regulator
IGS71_RS06815	COG1619	proteins homologs of microcin C7 resistance protein MccF
IGS71_RS06820	COG1506	peptidase
IGS71_RS06820	COG0823	Involved in the tonB-independent uptake of proteins
IGS71_RS06820	COG4946	Tricorn protease homolog
IGS71_RS06825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS71_RS06830	COG2362	D-Aminopeptidase
IGS71_RS06840	COG3938	Belongs to the proline racemase family
IGS71_RS06850	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS71_RS06860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS71_RS06875	COG2226	methyltransferase
IGS71_RS06880	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS71_RS06880	COG2208	phosphoserine phosphatase activity
IGS71_RS06880	COG2172	sigma factor antagonist activity
IGS71_RS06915	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS71_RS06925	COG0604	alcohol dehydrogenase
IGS71_RS06930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS06930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS06935	COG2301	Belongs to the HpcH HpaI aldolase family
IGS71_RS06945	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS06950	COG0688	phosphatidylethanolamine metabolic process
IGS71_RS06970	COG0559	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS06990	COG1929	Belongs to the glycerate kinase type-1 family
IGS71_RS07035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IGS71_RS07055	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IGS71_RS07065	COG0483	inositol monophosphate 1-phosphatase activity
IGS71_RS07085	COG1953	Uracil, thiamine, allantoin
IGS71_RS07095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS71_RS07100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS71_RS07115	COG0405	Gamma-glutamyltransferase
IGS71_RS07125	COG1126	abc transporter atp-binding protein
IGS71_RS07145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IGS71_RS07150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS71_RS07155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS71_RS07165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS71_RS07175	COG1940	carbohydrate kinase activity
IGS71_RS07195	COG2188	Transcriptional regulator
IGS71_RS07200	COG0673	inositol 2-dehydrogenase activity
IGS71_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS07215	COG4266	Belongs to the allantoicase family
IGS71_RS07220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS71_RS07225	COG1414	Transcriptional regulator
IGS71_RS07240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IGS71_RS07255	COG1131	(ABC) transporter
IGS71_RS07260	COG1725	Transcriptional regulator
IGS71_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS07300	COG0596	Alpha beta hydrolase
IGS71_RS07310	COG1335	isochorismatase
IGS71_RS07315	COG0723	plastoquinol--plastocyanin reductase activity
IGS71_RS07315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS71_RS07320	COG2124	cytochrome p450
IGS71_RS07330	COG0753	catalase activity
IGS71_RS07330	COG0693	protein deglycase activity
IGS71_RS07350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IGS71_RS07350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IGS71_RS07355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IGS71_RS07360	COG0297	glycogen (starch) synthase activity
IGS71_RS07370	COG0859	PFAM glycosyl transferase family 9
IGS71_RS07375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IGS71_RS07385	COG2192	nodulation
IGS71_RS07390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS71_RS07425	COG1024	Enoyl-CoA hydratase
IGS71_RS07435	COG0604	alcohol dehydrogenase
IGS71_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS07435	COG3321	synthase
IGS71_RS07445	COG0142	geranyltranstransferase activity
IGS71_RS07510	COG1132	(ABC) transporter
IGS71_RS07515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS07545	COG0436	Aminotransferase
IGS71_RS07555	COG1733	regulation of RNA biosynthetic process
IGS71_RS07580	COG2351	hydroxyisourate hydrolase activity
IGS71_RS07600	COG3622	Belongs to the hyi family
IGS71_RS07605	COG2084	Dehydrogenase
IGS71_RS07610	COG3960	tartronate-semialdehyde synthase activity
IGS71_RS07625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS71_RS07630	COG2197	response regulator
IGS71_RS07645	COG0598	Magnesium transport protein CorA
IGS71_RS07740	COG0598	Magnesium transport protein CorA
IGS71_RS07765	COG0142	geranyltranstransferase activity
IGS71_RS07770	COG1733	regulation of RNA biosynthetic process
IGS71_RS07815	COG2252	PERMEase
IGS71_RS07820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS71_RS07835	COG3835	regulator
IGS71_RS07845	COG1802	Transcriptional regulator
IGS71_RS07875	COG0028	Belongs to the TPP enzyme family
IGS71_RS07895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS71_RS07905	COG1162	GTPase activity
IGS71_RS07915	COG5297	Belongs to the glycosyl hydrolase family 6
IGS71_RS07925	COG1309	transcriptional regulator
IGS71_RS07935	COG0277	FAD linked oxidase domain protein
IGS71_RS07955	COG1175	transmembrane transport
IGS71_RS07960	COG0395	ABC-type sugar transport system, permease component
IGS71_RS07975	COG0402	S-adenosylhomocysteine deaminase activity
IGS71_RS08005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS71_RS08010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS71_RS08065	COG0583	DNA-binding transcription factor activity
IGS71_RS08070	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS08090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS71_RS08120	COG0142	geranyltranstransferase activity
IGS71_RS08160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS71_RS08165	COG2040	homocysteine
IGS71_RS08225	COG0667	Aldo Keto reductase
IGS71_RS08230	COG1132	(ABC) transporter
IGS71_RS08240	COG1505	serine-type exopeptidase activity
IGS71_RS08255	COG1609	Transcriptional regulator
IGS71_RS08275	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS08300	COG0175	sulfate reduction
IGS71_RS08305	COG0529	Catalyzes the synthesis of activated sulfate
IGS71_RS08330	COG1116	anion transmembrane transporter activity
IGS71_RS08330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IGS71_RS08335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS08350	COG1100	Small GTP-binding protein
IGS71_RS08390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGS71_RS08395	COG2409	Drug exporters of the RND superfamily
IGS71_RS08435	COG0583	DNA-binding transcription factor activity
IGS71_RS08485	COG1716	ATPase activity
IGS71_RS08495	COG3173	Aminoglycoside phosphotransferase
IGS71_RS08510	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IGS71_RS08520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS08530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IGS71_RS08550	COG1132	(ABC) transporter
IGS71_RS08560	COG2205	protein histidine kinase activity
IGS71_RS08565	COG0745	RESPONSE REGULATOR receiver
IGS71_RS08575	COG2755	lipolytic protein G-D-S-L family
IGS71_RS08575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IGS71_RS08615	COG1940	carbohydrate kinase activity
IGS71_RS08655	COG0642	Histidine kinase
IGS71_RS08675	COG0698	ribose 5-phosphate isomerase
IGS71_RS08680	COG0583	DNA-binding transcription factor activity
IGS71_RS08695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS71_RS08700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGS71_RS08755	COG0667	Aldo Keto reductase
IGS71_RS08770	COG3220	belongs to the UPF0276 family
IGS71_RS08785	COG3253	May function as heme-dependent peroxidase
IGS71_RS08800	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS71_RS08815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IGS71_RS08830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IGS71_RS08845	COG1414	Transcriptional regulator
IGS71_RS08850	COG3971	2-oxopent-4-enoate hydratase activity
IGS71_RS08855	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IGS71_RS08860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS71_RS08865	COG0183	Belongs to the thiolase family
IGS71_RS08870	COG1024	Enoyl-CoA hydratase
IGS71_RS08870	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS71_RS08890	COG2207	Transcriptional regulator
IGS71_RS08900	COG0531	amino acid
IGS71_RS08905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS71_RS08910	COG4214	carbohydrate transport
IGS71_RS08920	COG4213	ABC transporter substrate-binding protein
IGS71_RS08925	COG1940	carbohydrate kinase activity
IGS71_RS08930	COG0395	ABC-type sugar transport system, permease component
IGS71_RS08935	COG1175	transmembrane transport
IGS71_RS08940	COG1653	transport
IGS71_RS08965	COG2205	protein histidine kinase activity
IGS71_RS08970	COG0745	RESPONSE REGULATOR receiver
IGS71_RS08975	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IGS71_RS09000	COG4552	Acetyltransferase involved in intracellular survival and related
IGS71_RS09015	COG0583	DNA-binding transcription factor activity
IGS71_RS09025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS71_RS09050	COG0202	RNA polymerase activity
IGS71_RS09080	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS09085	COG2046	Belongs to the sulfate adenylyltransferase family
IGS71_RS09085	COG0529	Catalyzes the synthesis of activated sulfate
IGS71_RS09105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS71_RS09110	COG2235	arginine
IGS71_RS09150	COG2255	four-way junction helicase activity
IGS71_RS09160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGS71_RS09175	COG4585	Histidine kinase
IGS71_RS09195	COG4585	Histidine kinase
IGS71_RS09200	COG2197	response regulator
IGS71_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS09210	COG0702	epimerase
IGS71_RS09225	COG0583	DNA-binding transcription factor activity
IGS71_RS09250	COG1799	cell septum assembly
IGS71_RS09265	COG1309	transcriptional regulator
IGS71_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS09290	COG1309	transcriptional regulator
IGS71_RS09325	COG4842	Belongs to the WXG100 family
IGS71_RS09345	COG1674	ftsk spoiiie
IGS71_RS09350	COG1404	Belongs to the peptidase S8 family
IGS71_RS09355	COG0464	growth
IGS71_RS09375	COG2197	response regulator
IGS71_RS09465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGS71_RS09485	COG0367	asparagine synthase
IGS71_RS09520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGS71_RS09535	COG4310	Domain of unknown function (DUF2172)
IGS71_RS09545	COG1215	transferase activity, transferring glycosyl groups
IGS71_RS09555	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IGS71_RS09560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IGS71_RS09575	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS09645	COG0174	glutamine synthetase
IGS71_RS09675	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS71_RS09690	COG0535	radical SAM domain protein
IGS71_RS09730	COG1201	RNA secondary structure unwinding
IGS71_RS09740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS71_RS09745	COG0531	amino acid
IGS71_RS09750	COG0569	domain protein
IGS71_RS09780	COG1136	(ABC) transporter
IGS71_RS09795	COG0756	dUTP diphosphatase activity
IGS71_RS09820	COG2205	protein histidine kinase activity
IGS71_RS09825	COG0745	RESPONSE REGULATOR receiver
IGS71_RS09840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IGS71_RS09885	COG1435	thymidine kinase activity
IGS71_RS09905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS71_RS09910	COG1802	Transcriptional regulator
IGS71_RS09925	COG0612	Peptidase, M16
IGS71_RS09930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS71_RS09955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS71_RS09985	COG0367	asparagine synthase
IGS71_RS09995	COG2175	clavaminate synthase activity
IGS71_RS10005	COG1672	PFAM Archaeal ATPase
IGS71_RS10005	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IGS71_RS10020	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IGS71_RS10035	COG4249	Peptidase C14 caspase catalytic subunit p20
IGS71_RS10035	COG2319	Wd-40 repeat
IGS71_RS10040	COG4977	sequence-specific DNA binding
IGS71_RS10060	COG1136	(ABC) transporter
IGS71_RS10065	COG1136	(ABC) transporter
IGS71_RS10065	COG0577	efflux transmembrane transporter activity
IGS71_RS10070	COG0372	Belongs to the citrate synthase family
IGS71_RS10085	COG3290	protein histidine kinase activity
IGS71_RS10090	COG4565	transcriptional regulatory protein
IGS71_RS10095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS71_RS10105	COG2197	response regulator
IGS71_RS10110	COG4585	Histidine kinase
IGS71_RS10120	COG0187	DNA topoisomerase II activity
IGS71_RS10135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS71_RS10140	COG2186	Transcriptional regulator
IGS71_RS10160	COG0596	Alpha beta hydrolase
IGS71_RS10175	COG3629	intracellular signal transduction
IGS71_RS10175	COG3903	Transcriptional regulator
IGS71_RS10185	COG0783	Belongs to the Dps family
IGS71_RS10205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS71_RS10245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS71_RS10250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS71_RS10255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGS71_RS10270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGS71_RS10280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IGS71_RS10285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IGS71_RS10295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS71_RS10310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS71_RS10320	COG2205	protein histidine kinase activity
IGS71_RS10325	COG0745	RESPONSE REGULATOR receiver
IGS71_RS10330	COG1126	abc transporter atp-binding protein
IGS71_RS10335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS71_RS10340	COG0765	amino acid transport
IGS71_RS10345	COG0765	amino acid transport
IGS71_RS10360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGS71_RS10380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGS71_RS10385	COG0628	permease
IGS71_RS10415	COG1201	RNA secondary structure unwinding
IGS71_RS10420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS71_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS10430	COG0783	Belongs to the Dps family
IGS71_RS10435	COG1396	sequence-specific DNA binding
IGS71_RS10440	COG1058	Belongs to the CinA family
IGS71_RS10440	COG1546	Belongs to the CinA family
IGS71_RS10450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS71_RS10460	COG1674	ftsk spoiiie
IGS71_RS10475	COG2770	Histidine kinase
IGS71_RS10475	COG2208	phosphoserine phosphatase activity
IGS71_RS10505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IGS71_RS10510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS71_RS10515	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IGS71_RS10535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGS71_RS10540	COG0612	Peptidase, M16
IGS71_RS10545	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS71_RS10550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGS71_RS10560	COG0455	bacterial-type flagellum organization
IGS71_RS10570	COG0601	transmembrane transport
IGS71_RS10575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS10580	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS10585	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS10600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IGS71_RS10605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGS71_RS10615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IGS71_RS10630	COG0779	Required for maturation of 30S ribosomal subunits
IGS71_RS10650	COG0442	prolyl-tRNA aminoacylation
IGS71_RS10665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGS71_RS10670	COG0750	zinc metalloprotease
IGS71_RS10675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IGS71_RS10680	COG0653	protein targeting
IGS71_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS10715	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS10720	COG2508	Transcriptional regulator
IGS71_RS10750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS71_RS10755	COG1177	transmembrane transport
IGS71_RS10760	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS71_RS10765	COG3842	ATPase activity
IGS71_RS10790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS71_RS10810	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS10820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS71_RS10855	COG3842	ATPase activity
IGS71_RS10860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IGS71_RS10870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGS71_RS10950	COG0233	cytoplasmic translational termination
IGS71_RS10955	COG0528	UMP kinase activity
IGS71_RS10960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGS71_RS10965	COG0052	Belongs to the universal ribosomal protein uS2 family
IGS71_RS10980	COG1191	sigma factor activity
IGS71_RS10995	COG0792	nuclease activity
IGS71_RS11010	COG0681	Belongs to the peptidase S26 family
IGS71_RS11015	COG0681	Belongs to the peptidase S26 family
IGS71_RS11020	COG0681	Belongs to the peptidase S26 family
IGS71_RS11025	COG0681	Belongs to the peptidase S26 family
IGS71_RS11030	COG0335	large ribosomal subunit rRNA binding
IGS71_RS11035	COG0336	Belongs to the RNA methyltransferase TrmD family
IGS71_RS11040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGS71_RS11045	COG1837	Belongs to the UPF0109 family
IGS71_RS11050	COG0228	four-way junction DNA binding
IGS71_RS11060	COG0442	prolyl-tRNA aminoacylation
IGS71_RS11075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IGS71_RS11110	COG0477	Major facilitator Superfamily
IGS71_RS11125	COG1254	Belongs to the acylphosphatase family
IGS71_RS11130	COG2340	Cysteine-rich secretory protein family
IGS71_RS11135	COG1733	regulation of RNA biosynthetic process
IGS71_RS11160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS71_RS11165	COG0571	ribonuclease III activity
IGS71_RS11170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGS71_RS11185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGS71_RS11190	COG0742	ribosomal rna small subunit methyltransferase
IGS71_RS11200	COG0326	Molecular chaperone. Has ATPase activity
IGS71_RS11210	COG1461	Dihydroxyacetone kinase
IGS71_RS11215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS71_RS11240	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS71_RS11245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGS71_RS11255	COG1920	GTP binding
IGS71_RS11265	COG0776	regulation of translation
IGS71_RS11275	COG0066	3-isopropylmalate dehydratase activity
IGS71_RS11280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IGS71_RS11285	COG1414	Transcriptional regulator
IGS71_RS11320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS71_RS11325	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS11335	COG5002	protein histidine kinase activity
IGS71_RS11340	COG2018	Roadblock/LC7 domain
IGS71_RS11360	COG2018	Roadblock/LC7 domain
IGS71_RS11395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS71_RS11400	COG5492	domain, Protein
IGS71_RS11405	COG2353	YceI-like domain
IGS71_RS11425	COG1131	(ABC) transporter
IGS71_RS11455	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS11460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS71_RS11465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGS71_RS11470	COG0473	3-isopropylmalate dehydrogenase activity
IGS71_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS11485	COG0506	proline dehydrogenase activity
IGS71_RS11490	COG3835	regulator
IGS71_RS11520	COG0477	Major facilitator Superfamily
IGS71_RS11530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IGS71_RS11535	COG0440	acetolactate synthase activity
IGS71_RS11545	COG5001	Diguanylate cyclase
IGS71_RS11555	COG0667	Aldo Keto reductase
IGS71_RS11560	COG2133	pyrroloquinoline quinone binding
IGS71_RS11570	COG2197	response regulator
IGS71_RS11585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS71_RS11590	COG2409	Drug exporters of the RND superfamily
IGS71_RS11605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS71_RS11615	COG0154	amidase activity
IGS71_RS11620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS71_RS11630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS71_RS11640	COG4221	oxidoreductase activity
IGS71_RS11645	COG1611	Belongs to the LOG family
IGS71_RS11680	COG1509	lysine 2,3-aminomutase activity
IGS71_RS11685	COG0482	sulfurtransferase activity
IGS71_RS11720	COG2860	membrane
IGS71_RS11725	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS11730	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS11740	COG4166	transmembrane transport
IGS71_RS11745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS11765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS71_RS11770	COG0509	glycine decarboxylation via glycine cleavage system
IGS71_RS11775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS71_RS11780	COG1760	l-serine dehydratase
IGS71_RS11840	COG2130	NADP-dependent
IGS71_RS11865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS71_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS11915	COG0702	epimerase
IGS71_RS11920	COG0655	NAD(P)H dehydrogenase (quinone) activity
IGS71_RS11945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS11980	COG1376	ErfK ybiS ycfS ynhG family protein
IGS71_RS11995	COG1132	(ABC) transporter
IGS71_RS12000	COG1132	(ABC) transporter
IGS71_RS12010	COG1132	(ABC) transporter
IGS71_RS12025	COG0058	SHG alpha-glucan phosphorylase activity
IGS71_RS12030	COG0366	Alpha amylase catalytic
IGS71_RS12040	COG3281	Trehalose synthase
IGS71_RS12045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS71_RS12065	COG1301	dicarboxylic acid transport
IGS71_RS12070	COG3290	protein histidine kinase activity
IGS71_RS12075	COG4565	transcriptional regulatory protein
IGS71_RS12090	COG0395	ABC-type sugar transport system, permease component
IGS71_RS12100	COG4221	oxidoreductase activity
IGS71_RS12130	COG0205	6-phosphofructokinase activity
IGS71_RS12135	COG0280	phosphate acetyltransferase
IGS71_RS12135	COG0857	belongs to the CobB CobQ family
IGS71_RS12140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS71_RS12180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS12180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS12195	COG1309	transcriptional regulator
IGS71_RS12265	COG0745	RESPONSE REGULATOR receiver
IGS71_RS12280	COG0183	Belongs to the thiolase family
IGS71_RS12300	COG1131	(ABC) transporter
IGS71_RS12335	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IGS71_RS12350	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS71_RS12370	COG2197	response regulator
IGS71_RS12395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGS71_RS12400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGS71_RS12405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGS71_RS12410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGS71_RS12415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS71_RS12420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS71_RS12425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS71_RS12440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS71_RS12445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS71_RS12450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS71_RS12465	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS71_RS12470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGS71_RS12475	COG0254	rRNA binding
IGS71_RS12490	COG0083	homoserine kinase activity
IGS71_RS12495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IGS71_RS12500	COG0460	homoserine dehydrogenase
IGS71_RS12505	COG0019	diaminopimelate decarboxylase activity
IGS71_RS12510	COG0018	arginyl-trna synthetase
IGS71_RS12560	COG0596	Alpha beta hydrolase
IGS71_RS12575	COG1609	Transcriptional regulator
IGS71_RS12585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS71_RS12590	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IGS71_RS12615	COG0772	Belongs to the SEDS family
IGS71_RS12620	COG0768	penicillin binding
IGS71_RS12675	COG1309	transcriptional regulator
IGS71_RS12685	COG0791	NLP P60 protein
IGS71_RS12685	COG3883	PFAM NLP P60 protein
IGS71_RS12705	COG2018	Roadblock/LC7 domain
IGS71_RS12725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS71_RS12740	COG0745	RESPONSE REGULATOR receiver
IGS71_RS12745	COG2205	protein histidine kinase activity
IGS71_RS12750	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS71_RS12750	COG0567	Dehydrogenase, E1 component
IGS71_RS12755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS71_RS12795	COG0604	alcohol dehydrogenase
IGS71_RS12800	COG0281	malic enzyme
IGS71_RS12815	COG1126	abc transporter atp-binding protein
IGS71_RS12850	COG4941	Belongs to the sigma-70 factor family
IGS71_RS12865	COG0142	geranyltranstransferase activity
IGS71_RS12870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS71_RS12915	COG1597	lipid kinase activity
IGS71_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS12940	COG0363	glucosamine-6-phosphate deaminase activity
IGS71_RS12945	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS12950	COG0395	ABC-type sugar transport system, permease component
IGS71_RS12955	COG1175	transmembrane transport
IGS71_RS12960	COG2182	Extracellular solute-binding protein
IGS71_RS12965	COG2188	Transcriptional regulator
IGS71_RS12970	COG1966	Carbon starvation protein
IGS71_RS13000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS71_RS13015	COG2124	cytochrome p450
IGS71_RS13025	COG0242	peptide deformylase activity
IGS71_RS13060	COG1595	DNA-templated transcription, initiation
IGS71_RS13070	COG2135	peptidase activity
IGS71_RS13080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGS71_RS13085	COG1162	GTPase activity
IGS71_RS13100	COG0483	inositol monophosphate 1-phosphatase activity
IGS71_RS13110	COG0753	catalase activity
IGS71_RS13135	COG1615	UPF0182 protein
IGS71_RS13145	COG3480	Lon protease (S16) C-terminal proteolytic domain
IGS71_RS13200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IGS71_RS13235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS71_RS13240	COG0210	DNA helicase
IGS71_RS13265	COG0596	Alpha beta hydrolase
IGS71_RS13305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS13310	COG0747	negative chemotaxis
IGS71_RS13350	COG0513	Belongs to the DEAD box helicase family
IGS71_RS13360	COG1432	Conserved Protein
IGS71_RS13370	COG2095	MarC family integral membrane protein
IGS71_RS13375	COG0613	PHP domain protein
IGS71_RS13385	COG2814	Major facilitator Superfamily
IGS71_RS13395	COG0598	Magnesium transport protein CorA
IGS71_RS13430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS71_RS13435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS71_RS13445	COG1595	DNA-templated transcription, initiation
IGS71_RS13460	COG1024	Enoyl-CoA hydratase
IGS71_RS13465	COG2818	Glycosylase
IGS71_RS13475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IGS71_RS13485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS71_RS13525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS71_RS13555	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS13560	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS13565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS13570	COG0601	transmembrane transport
IGS71_RS13605	COG1136	(ABC) transporter
IGS71_RS13610	COG4585	Histidine kinase
IGS71_RS13615	COG2197	response regulator
IGS71_RS13620	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS13625	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS13630	COG0601	transmembrane transport
IGS71_RS13635	COG0747	negative chemotaxis
IGS71_RS13640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS13645	COG1217	gtp-binding protein TYPA
IGS71_RS13665	COG1053	succinate dehydrogenase
IGS71_RS13670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IGS71_RS13725	COG4585	Histidine kinase
IGS71_RS13730	COG2197	response regulator
IGS71_RS13740	COG0667	Aldo Keto reductase
IGS71_RS13780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS71_RS13810	COG0243	molybdopterin cofactor binding
IGS71_RS13845	COG0012	GTP binding
IGS71_RS13860	COG2267	carboxylic ester hydrolase activity
IGS71_RS13870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IGS71_RS13880	COG1570	exodeoxyribonuclease VII activity
IGS71_RS13885	COG1722	exodeoxyribonuclease VII activity
IGS71_RS13890	COG0778	Nitroreductase
IGS71_RS13915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IGS71_RS13915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IGS71_RS13920	COG0114	fumarate hydratase activity
IGS71_RS13935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS71_RS13950	COG1136	(ABC) transporter
IGS71_RS13960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS71_RS13980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IGS71_RS13985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS71_RS13995	COG0640	Transcriptional regulator
IGS71_RS14020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS71_RS14030	COG0640	Transcriptional regulator
IGS71_RS14040	COG2885	chlorophyll binding
IGS71_RS14060	COG2197	response regulator
IGS71_RS14090	COG2894	cell division
IGS71_RS14120	COG2610	gluconate transmembrane transporter activity
IGS71_RS14125	COG0251	oxidation-reduction process
IGS71_RS14130	COG1414	Transcriptional regulator
IGS71_RS14135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS14145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IGS71_RS14185	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IGS71_RS14195	COG0477	Major facilitator Superfamily
IGS71_RS14200	COG1309	transcriptional regulator
IGS71_RS14235	COG1331	Highly conserved protein containing a thioredoxin domain
IGS71_RS14250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS71_RS14260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS71_RS14275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS71_RS14280	COG2255	four-way junction helicase activity
IGS71_RS14305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS71_RS14315	COG1064	alcohol dehydrogenase
IGS71_RS14340	COG1404	Belongs to the peptidase S8 family
IGS71_RS14345	COG1136	(ABC) transporter
IGS71_RS14395	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS14400	COG0513	Belongs to the DEAD box helicase family
IGS71_RS14405	COG1278	Cold shock
IGS71_RS14410	COG2986	histidine ammonia-lyase
IGS71_RS14420	COG1024	Enoyl-CoA hydratase
IGS71_RS14425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IGS71_RS14435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS71_RS14450	COG0424	maF-like protein
IGS71_RS14460	COG4770	biotin carboxylase activity
IGS71_RS14470	COG1349	DNA-binding transcription factor activity
IGS71_RS14490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS71_RS14510	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS14515	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS14530	COG1595	DNA-templated transcription, initiation
IGS71_RS14535	COG0745	RESPONSE REGULATOR receiver
IGS71_RS14540	COG2205	protein histidine kinase activity
IGS71_RS14565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS71_RS14580	COG2207	Transcriptional regulator
IGS71_RS14590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IGS71_RS14595	COG0583	DNA-binding transcription factor activity
IGS71_RS14600	COG2814	Major facilitator Superfamily
IGS71_RS14630	COG4603	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS14635	COG3845	ABC transporter
IGS71_RS14640	COG1744	ABC transporter substrate-binding protein PnrA-like
IGS71_RS14645	COG1744	ABC transporter substrate-binding protein PnrA-like
IGS71_RS14650	COG1473	amidohydrolase
IGS71_RS14650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IGS71_RS14660	COG2089	acid synthase
IGS71_RS14675	COG1216	Glycosyl transferase, family 2
IGS71_RS14685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IGS71_RS14710	COG1595	DNA-templated transcription, initiation
IGS71_RS14730	COG1595	DNA-templated transcription, initiation
IGS71_RS14765	COG2009	succinate dehydrogenase
IGS71_RS14775	COG1053	succinate dehydrogenase
IGS71_RS14825	COG0667	Aldo Keto reductase
IGS71_RS14835	COG3320	Male sterility
IGS71_RS14835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS14920	COG2409	Drug exporters of the RND superfamily
IGS71_RS14925	COG0745	RESPONSE REGULATOR receiver
IGS71_RS14930	COG2205	protein histidine kinase activity
IGS71_RS14935	COG1408	metallophosphoesterase
IGS71_RS14940	COG1686	Belongs to the peptidase S11 family
IGS71_RS14945	COG1295	ribonuclease BN
IGS71_RS14980	COG0180	Tryptophanyl-tRNA synthetase
IGS71_RS14985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS71_RS14990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS71_RS14995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS71_RS15000	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS15025	COG0039	L-malate dehydrogenase activity
IGS71_RS15040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGS71_RS15055	COG0515	serine threonine protein kinase
IGS71_RS15055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS71_RS15070	COG0138	bifunctional purine biosynthesis protein purh
IGS71_RS15100	COG0045	succinate-CoA ligase (ADP-forming) activity
IGS71_RS15115	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IGS71_RS15120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IGS71_RS15125	COG0714	Associated with various cellular activities
IGS71_RS15140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS15175	COG0384	phenazine biosynthesis protein PhzF
IGS71_RS15200	COG2197	response regulator
IGS71_RS15275	COG0519	Catalyzes the synthesis of GMP from XMP
IGS71_RS15275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IGS71_RS15305	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS15310	COG0515	serine threonine protein kinase
IGS71_RS15320	COG0515	serine threonine protein kinase
IGS71_RS15325	COG0515	serine threonine protein kinase
IGS71_RS15325	COG2815	serine threonine protein kinase
IGS71_RS15330	COG0515	serine threonine protein kinase
IGS71_RS15345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IGS71_RS15355	COG0516	GMP reductase activity
IGS71_RS15365	COG1595	DNA-templated transcription, initiation
IGS71_RS15380	COG0583	DNA-binding transcription factor activity
IGS71_RS15395	COG0459	protein refolding
IGS71_RS15400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGS71_RS15405	COG0726	polysaccharide deacetylase
IGS71_RS15410	COG0726	polysaccharide deacetylase
IGS71_RS15425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IGS71_RS15440	COG2205	protein histidine kinase activity
IGS71_RS15445	COG0745	RESPONSE REGULATOR receiver
IGS71_RS15450	COG3104	oligopeptide transport
IGS71_RS15485	COG1191	sigma factor activity
IGS71_RS15505	COG1228	amidohydrolase
IGS71_RS15515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS71_RS15520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IGS71_RS15575	COG2755	lipolytic protein G-D-S-L family
IGS71_RS15580	COG0183	Belongs to the thiolase family
IGS71_RS15615	COG1136	(ABC) transporter
IGS71_RS15620	COG1136	(ABC) transporter
IGS71_RS15620	COG0577	efflux transmembrane transporter activity
IGS71_RS15625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGS71_RS15630	COG1252	NADH dehydrogenase
IGS71_RS15675	COG0148	phosphopyruvate hydratase activity
IGS71_RS15750	COG0577	efflux transmembrane transporter activity
IGS71_RS15755	COG1136	(ABC) transporter
IGS71_RS15760	COG2814	Major facilitator Superfamily
IGS71_RS15790	COG4585	Histidine kinase
IGS71_RS15800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGS71_RS15805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS71_RS15810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IGS71_RS15815	COG0193	aminoacyl-tRNA hydrolase activity
IGS71_RS15825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IGS71_RS15835	COG1309	transcriptional regulator
IGS71_RS15850	COG4106	trans-aconitate 2-methyltransferase activity
IGS71_RS15855	COG1846	Transcriptional regulator
IGS71_RS15860	COG2197	response regulator
IGS71_RS15870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IGS71_RS15895	COG0583	DNA-binding transcription factor activity
IGS71_RS15930	COG0488	(ABC) transporter
IGS71_RS15935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGS71_RS15950	COG0084	hydrolase, TatD family'
IGS71_RS15990	COG0310	cobalt ion transport
IGS71_RS16000	COG1122	ATPase activity
IGS71_RS16005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS71_RS16020	COG0442	prolyl-tRNA aminoacylation
IGS71_RS16025	COG2409	Drug exporters of the RND superfamily
IGS71_RS16035	COG0793	Belongs to the peptidase S41A family
IGS71_RS16035	COG4946	Tricorn protease homolog
IGS71_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS16050	COG0596	Alpha beta hydrolase
IGS71_RS16055	COG2072	flavoprotein involved in K transport
IGS71_RS16065	COG0708	Exodeoxyribonuclease III
IGS71_RS16085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS71_RS16090	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS71_RS16090	COG0521	Mo-molybdopterin cofactor biosynthetic process
IGS71_RS16095	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS71_RS16105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IGS71_RS16110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IGS71_RS16115	COG2366	antibiotic biosynthetic process
IGS71_RS16120	COG3263	regulation of cellular component size
IGS71_RS16135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IGS71_RS16145	COG1970	mechanosensitive ion channel activity
IGS71_RS16160	COG3572	ergothioneine biosynthetic process
IGS71_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS16175	COG3191	aminopeptidase activity
IGS71_RS16185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS71_RS16185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS71_RS16195	COG1349	DNA-binding transcription factor activity
IGS71_RS16200	COG0477	Major facilitator Superfamily
IGS71_RS16215	COG1247	-acetyltransferase
IGS71_RS16220	COG3384	dioxygenase
IGS71_RS16225	COG1846	Transcriptional regulator
IGS71_RS16245	COG1414	Transcriptional regulator
IGS71_RS16250	COG1309	transcriptional regulator
IGS71_RS16270	COG4948	Mandelate Racemase Muconate Lactonizing
IGS71_RS16275	COG1414	Transcriptional regulator
IGS71_RS16300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGS71_RS16395	COG2186	Transcriptional regulator
IGS71_RS16645	COG1857	crispr-associated protein
IGS71_RS16660	COG1518	maintenance of DNA repeat elements
IGS71_RS16665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGS71_RS16670	COG0367	asparagine synthase
IGS71_RS16725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS71_RS16785	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS16810	COG0477	Major facilitator Superfamily
IGS71_RS16825	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS16860	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS16930	COG0412	Dienelactone hydrolase
IGS71_RS16955	COG3485	protocatechuate 3,4-dioxygenase
IGS71_RS16975	COG0583	DNA-binding transcription factor activity
IGS71_RS16980	COG0183	Belongs to the thiolase family
IGS71_RS16990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IGS71_RS17000	COG2205	protein histidine kinase activity
IGS71_RS17005	COG0745	RESPONSE REGULATOR receiver
IGS71_RS17030	COG2205	protein histidine kinase activity
IGS71_RS17035	COG0745	RESPONSE REGULATOR receiver
IGS71_RS17040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IGS71_RS17060	COG0582	viral genome integration into host DNA
IGS71_RS17225	COG0386	Belongs to the glutathione peroxidase family
IGS71_RS17235	COG1686	Belongs to the peptidase S11 family
IGS71_RS17280	COG1396	sequence-specific DNA binding
IGS71_RS17300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IGS71_RS17335	COG0667	Aldo Keto reductase
IGS71_RS17355	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS17375	COG1309	transcriptional regulator
IGS71_RS17385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IGS71_RS17400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS71_RS17460	COG3903	Transcriptional regulator
IGS71_RS17460	COG3629	intracellular signal transduction
IGS71_RS17480	COG2197	response regulator
IGS71_RS17520	COG1024	Enoyl-CoA hydratase
IGS71_RS17525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS71_RS17535	COG2319	Wd-40 repeat
IGS71_RS17535	COG4249	Peptidase C14 caspase catalytic subunit p20
IGS71_RS17540	COG0515	serine threonine protein kinase
IGS71_RS17540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS71_RS17550	COG1309	transcriptional regulator
IGS71_RS17555	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS17610	COG2072	flavoprotein involved in K transport
IGS71_RS17630	COG0259	pyridoxamine-phosphate oxidase activity
IGS71_RS17680	COG1024	Enoyl-CoA hydratase
IGS71_RS17690	COG2814	Major facilitator Superfamily
IGS71_RS17760	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS17780	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS17785	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS17805	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS71_RS17810	COG1595	DNA-templated transcription, initiation
IGS71_RS17860	COG2945	thiolester hydrolase activity
IGS71_RS17860	COG0596	Alpha beta hydrolase
IGS71_RS17870	COG4821	SIS domain
IGS71_RS17885	COG0259	pyridoxamine-phosphate oxidase activity
IGS71_RS17900	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS17915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS71_RS17945	COG0277	FAD linked oxidase domain protein
IGS71_RS17945	COG0247	lactate metabolic process
IGS71_RS17975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IGS71_RS18010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS71_RS18015	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IGS71_RS18020	COG2205	protein histidine kinase activity
IGS71_RS18025	COG0745	RESPONSE REGULATOR receiver
IGS71_RS18040	COG1136	(ABC) transporter
IGS71_RS18045	COG0577	efflux transmembrane transporter activity
IGS71_RS18045	COG1136	(ABC) transporter
IGS71_RS18070	COG0604	alcohol dehydrogenase
IGS71_RS18130	COG0667	Aldo Keto reductase
IGS71_RS18145	COG1595	DNA-templated transcription, initiation
IGS71_RS18170	COG2252	PERMEase
IGS71_RS18180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IGS71_RS18185	COG1595	DNA-templated transcription, initiation
IGS71_RS18195	COG1131	(ABC) transporter
IGS71_RS18220	COG2814	Major facilitator Superfamily
IGS71_RS18230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IGS71_RS18235	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IGS71_RS18240	COG1278	Cold shock
IGS71_RS18275	COG1061	Type III restriction enzyme res subunit
IGS71_RS18285	COG3973	AAA domain
IGS71_RS18330	COG1737	Transcriptional regulator
IGS71_RS18335	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IGS71_RS18350	COG0702	epimerase
IGS71_RS18360	COG0459	protein refolding
IGS71_RS18380	COG0463	Glycosyl transferase, family 2
IGS71_RS18410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IGS71_RS18430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS71_RS18435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IGS71_RS18465	COG0723	plastoquinol--plastocyanin reductase activity
IGS71_RS18465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS71_RS18475	COG4585	Histidine kinase
IGS71_RS18480	COG2197	response regulator
IGS71_RS18485	COG0577	efflux transmembrane transporter activity
IGS71_RS18485	COG1136	(ABC) transporter
IGS71_RS18500	COG2755	lipolytic protein G-D-S-L family
IGS71_RS18505	COG2197	response regulator
IGS71_RS18510	COG4585	Histidine kinase
IGS71_RS18515	COG2409	Drug exporters of the RND superfamily
IGS71_RS18520	COG2205	protein histidine kinase activity
IGS71_RS18525	COG0745	RESPONSE REGULATOR receiver
IGS71_RS18535	COG1131	(ABC) transporter
IGS71_RS18560	COG3842	ATPase activity
IGS71_RS18580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS71_RS18585	COG0215	cysteine-tRNA ligase activity
IGS71_RS18590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IGS71_RS18595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IGS71_RS18600	COG1329	Transcriptional regulator
IGS71_RS18615	COG5002	protein histidine kinase activity
IGS71_RS18630	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS18635	COG0583	DNA-binding transcription factor activity
IGS71_RS18675	COG2188	Transcriptional regulator
IGS71_RS18715	COG4974	Belongs to the 'phage' integrase family
IGS71_RS18725	COG0588	phosphoglycerate mutase activity
IGS71_RS18770	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS18840	COG3973	AAA domain
IGS71_RS18855	COG0546	phosphoglycolate phosphatase activity
IGS71_RS18860	COG0546	phosphoglycolate phosphatase activity
IGS71_RS18865	COG2186	Transcriptional regulator
IGS71_RS18885	COG4552	Acetyltransferase involved in intracellular survival and related
IGS71_RS18895	COG1490	D-aminoacyl-tRNA deacylase activity
IGS71_RS18905	COG0735	belongs to the Fur family
IGS71_RS18910	COG3485	protocatechuate 3,4-dioxygenase
IGS71_RS18950	COG2897	thiosulfate sulfurtransferase activity
IGS71_RS18975	COG0745	RESPONSE REGULATOR receiver
IGS71_RS18980	COG1609	Transcriptional regulator
IGS71_RS18990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS71_RS19000	COG0745	RESPONSE REGULATOR receiver
IGS71_RS19025	COG0596	Alpha beta hydrolase
IGS71_RS19070	COG0300	oxidoreductase activity
IGS71_RS19075	COG1309	transcriptional regulator
IGS71_RS19080	COG0596	Alpha beta hydrolase
IGS71_RS19095	COG1132	(ABC) transporter
IGS71_RS19100	COG0737	Belongs to the 5'-nucleotidase family
IGS71_RS19105	COG0456	acetyltransferase
IGS71_RS19120	COG1131	(ABC) transporter
IGS71_RS19140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IGS71_RS19165	COG1937	Protein conserved in bacteria
IGS71_RS19175	COG0306	phosphate transporter
IGS71_RS19180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS71_RS19200	COG0277	FAD linked oxidase domain protein
IGS71_RS19205	COG0671	phosphoesterase, PA-phosphatase related
IGS71_RS19210	COG0739	heme binding
IGS71_RS19210	COG0741	lytic transglycosylase activity
IGS71_RS19210	COG1196	nuclear chromosome segregation
IGS71_RS19335	COG1252	NADH dehydrogenase
IGS71_RS19360	COG0579	oxidoreductase
IGS71_RS19365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IGS71_RS19405	COG0791	NLP P60 protein
IGS71_RS19405	COG1388	LysM domain
IGS71_RS19420	COG0513	Belongs to the DEAD box helicase family
IGS71_RS19460	COG1643	Atp-dependent helicase
IGS71_RS19490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IGS71_RS19510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS71_RS19515	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS71_RS19520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS71_RS19555	COG2197	response regulator
IGS71_RS19565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IGS71_RS19580	COG0151	Belongs to the GarS family
IGS71_RS19625	COG1063	alcohol dehydrogenase
IGS71_RS19660	COG0577	efflux transmembrane transporter activity
IGS71_RS19660	COG1136	(ABC) transporter
IGS71_RS19665	COG0577	efflux transmembrane transporter activity
IGS71_RS19675	COG2207	Transcriptional regulator
IGS71_RS19680	COG0667	Aldo Keto reductase
IGS71_RS19715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IGS71_RS19755	COG1191	sigma factor activity
IGS71_RS19760	COG1191	sigma factor activity
IGS71_RS19780	COG0477	Major facilitator Superfamily
IGS71_RS19785	COG2353	YceI-like domain
IGS71_RS19790	COG3467	pyridoxamine 5'-phosphate
IGS71_RS19795	COG2409	Drug exporters of the RND superfamily
IGS71_RS19800	COG2197	response regulator
IGS71_RS19805	COG4585	Histidine kinase
IGS71_RS19820	COG0477	Major facilitator Superfamily
IGS71_RS19825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IGS71_RS19835	COG2205	protein histidine kinase activity
IGS71_RS19840	COG0745	RESPONSE REGULATOR receiver
IGS71_RS19850	COG2329	Antibiotic biosynthesis monooxygenase
IGS71_RS19860	COG1846	Transcriptional regulator
IGS71_RS19870	COG0494	nUDIX hydrolase
IGS71_RS19910	COG0582	viral genome integration into host DNA
IGS71_RS19935	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS19940	COG1595	DNA-templated transcription, initiation
IGS71_RS19960	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS19970	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS20025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS71_RS20040	COG0653	protein targeting
IGS71_RS20060	COG0006	proline dipeptidase activity
IGS71_RS20065	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IGS71_RS20085	COG1999	signal sequence binding
IGS71_RS20100	COG2837	iron assimilation
IGS71_RS20105	COG0077	Prephenate dehydratase
IGS71_RS20110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGS71_RS20115	COG0561	phosphatase activity
IGS71_RS20140	COG1131	(ABC) transporter
IGS71_RS20150	COG0789	Transcriptional regulator
IGS71_RS20155	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IGS71_RS20165	COG0561	phosphatase activity
IGS71_RS20170	COG0739	heme binding
IGS71_RS20170	COG0741	lytic transglycosylase activity
IGS71_RS20170	COG1196	nuclear chromosome segregation
IGS71_RS20180	COG4988	ABC transporter
IGS71_RS20185	COG1294	oxidase, subunit
IGS71_RS20190	COG1271	oxidase subunit
IGS71_RS20195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS71_RS20200	COG1609	Transcriptional regulator
IGS71_RS20235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IGS71_RS20260	COG0662	Cupin 2, conserved barrel domain protein
IGS71_RS20265	COG1950	PFAM Membrane protein of
IGS71_RS20270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS71_RS20275	COG0626	cystathionine gamma-synthase activity
IGS71_RS20290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS71_RS20290	COG1017	nitric oxide dioxygenase activity
IGS71_RS20315	COG2814	Major facilitator Superfamily
IGS71_RS20330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS71_RS20335	COG0305	Participates in initiation and elongation during chromosome replication
IGS71_RS20345	COG0359	binds to the 23S rRNA
IGS71_RS20350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS71_RS20355	COG0629	single-stranded DNA binding
IGS71_RS20360	COG0360	Binds together with S18 to 16S ribosomal RNA
IGS71_RS20385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS71_RS20395	COG1260	myo-inositol-1-phosphate synthase
IGS71_RS20430	COG1595	DNA-templated transcription, initiation
IGS71_RS20440	COG0492	ferredoxin-NADP+ reductase activity
IGS71_RS20445	COG3118	belongs to the thioredoxin family
IGS71_RS20460	COG1192	Involved in chromosome partitioning
IGS71_RS20465	COG0357	Ribosomal RNA small subunit methyltransferase G
IGS71_RS20475	COG0706	membrane insertase activity
IGS71_RS20480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGS71_RS20485	COG0594	ribonuclease P activity
IGS71_RS20490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IGS71_RS20495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IGS71_RS20500	COG0592	DNA-directed DNA polymerase activity
IGS71_RS20505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGS71_RS20510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGS71_RS20515	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IGS71_RS20520	COG0187	DNA topoisomerase II activity
IGS71_RS20525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS71_RS20540	COG0582	viral genome integration into host DNA
IGS71_RS20620	COG0515	serine threonine protein kinase
IGS71_RS20645	COG0705	Rhomboid family
IGS71_RS20660	COG3764	Sortase (surface protein transpeptidase)
IGS71_RS20675	COG3764	Sortase (surface protein transpeptidase)
IGS71_RS20680	COG3764	Sortase (surface protein transpeptidase)
IGS71_RS20690	COG0515	serine threonine protein kinase
IGS71_RS20710	COG1716	ATPase activity
IGS71_RS20715	COG1716	ATPase activity
IGS71_RS20740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGS71_RS20745	COG1733	regulation of RNA biosynthetic process
IGS71_RS20795	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS71_RS20800	COG1309	transcriptional regulator
IGS71_RS20805	COG1522	sequence-specific DNA binding
IGS71_RS20830	COG0303	'Molybdopterin
IGS71_RS20860	COG0515	serine threonine protein kinase
IGS71_RS20865	COG0515	serine threonine protein kinase
IGS71_RS20880	COG0022	dehydrogenase e1 component
IGS71_RS20885	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS71_RS20900	COG2271	Major facilitator Superfamily
IGS71_RS20975	COG1362	aminopeptidase activity
IGS71_RS20980	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS21000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS71_RS21055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS71_RS21070	COG0583	DNA-binding transcription factor activity
IGS71_RS21085	COG2267	carboxylic ester hydrolase activity
IGS71_RS21090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS71_RS21140	COG1396	sequence-specific DNA binding
IGS71_RS21145	COG0701	Predicted permease
IGS71_RS21165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS71_RS21175	COG1595	DNA-templated transcription, initiation
IGS71_RS21190	COG0596	Alpha beta hydrolase
IGS71_RS21210	COG0515	serine threonine protein kinase
IGS71_RS21210	COG2815	serine threonine protein kinase
IGS71_RS21225	COG2268	Band 7 protein
IGS71_RS21310	COG0513	Belongs to the DEAD box helicase family
IGS71_RS21315	COG1278	Cold shock
IGS71_RS21325	COG1073	alpha beta
IGS71_RS21330	COG2409	Drug exporters of the RND superfamily
IGS71_RS21335	COG4585	Histidine kinase
IGS71_RS21340	COG2197	response regulator
IGS71_RS21350	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IGS71_RS21350	COG2508	Transcriptional regulator
IGS71_RS21365	COG2197	response regulator
IGS71_RS21380	COG2814	Major facilitator Superfamily
IGS71_RS21380	COG0477	Major facilitator Superfamily
IGS71_RS21390	COG2159	amidohydrolase
IGS71_RS21395	COG0745	RESPONSE REGULATOR receiver
IGS71_RS21400	COG2205	protein histidine kinase activity
IGS71_RS21430	COG3903	Transcriptional regulator
IGS71_RS21430	COG3629	intracellular signal transduction
IGS71_RS21475	COG2815	serine threonine protein kinase
IGS71_RS21475	COG0515	serine threonine protein kinase
IGS71_RS21480	COG0515	serine threonine protein kinase
IGS71_RS21480	COG2815	serine threonine protein kinase
IGS71_RS21540	COG0717	Belongs to the dCTP deaminase family
IGS71_RS21565	COG1846	Transcriptional regulator
IGS71_RS21570	COG2175	clavaminate synthase activity
IGS71_RS21575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS71_RS21590	COG2207	Transcriptional regulator
IGS71_RS21590	COG3708	Transcriptional regulator
IGS71_RS21710	COG0464	growth
IGS71_RS21735	COG0247	lactate metabolic process
IGS71_RS21735	COG2181	nitrate reductase activity
IGS71_RS21740	COG0443	Heat shock 70 kDa protein
IGS71_RS21745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS71_RS21750	COG0484	heat shock protein binding
IGS71_RS21755	COG0789	Transcriptional regulator
IGS71_RS21825	COG4213	ABC transporter substrate-binding protein
IGS71_RS21855	COG0542	response to heat
IGS71_RS21905	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IGS71_RS21920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS71_RS21925	COG0191	fructose-bisphosphate aldolase activity
IGS71_RS21940	COG3483	tryptophan 2,3-dioxygenase activity
IGS71_RS21945	COG3844	kynureninase activity
IGS71_RS21965	COG2197	response regulator
IGS71_RS21975	COG3559	Exporter of polyketide antibiotics
IGS71_RS21980	COG1131	(ABC) transporter
IGS71_RS21995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGS71_RS22015	COG1802	Transcriptional regulator
IGS71_RS22030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IGS71_RS22035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IGS71_RS22055	COG1595	DNA-templated transcription, initiation
IGS71_RS22080	COG0701	Predicted permease
IGS71_RS22130	COG1408	metallophosphoesterase
IGS71_RS22140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS71_RS22150	COG0003	Pfam Anion-transporting ATPase
IGS71_RS22175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS71_RS22200	COG0596	Alpha beta hydrolase
IGS71_RS22210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGS71_RS22215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS71_RS22220	COG0288	reversible hydration of carbon dioxide
IGS71_RS22275	COG1205	dead DEAH box helicase
IGS71_RS22275	COG1111	helicase
IGS71_RS22280	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS71_RS22285	COG2172	sigma factor antagonist activity
IGS71_RS22290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IGS71_RS22300	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS71_RS22310	COG1754	DNA topoisomerase type I activity
IGS71_RS22310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGS71_RS22315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS71_RS22345	COG2382	esterase
IGS71_RS22350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS22355	COG3433	isochorismatase activity
IGS71_RS22355	COG1535	isochorismatase
IGS71_RS22360	COG3433	isochorismatase activity
IGS71_RS22360	COG1535	isochorismatase
IGS71_RS22365	COG1021	2,3-dihydroxybenzoate-AMP ligase
IGS71_RS22370	COG1169	isochorismate synthase
IGS71_RS22375	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS22380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IGS71_RS22385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS22390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS22395	COG1120	ATPase activity
IGS71_RS22455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS71_RS22460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS71_RS22470	COG2197	response regulator
IGS71_RS22475	COG4585	Histidine kinase
IGS71_RS22480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS71_RS22485	COG2409	Drug exporters of the RND superfamily
IGS71_RS22525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS71_RS22525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS71_RS22555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS71_RS22560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS71_RS22565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS71_RS22570	COG0254	rRNA binding
IGS71_RS22580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS71_RS22600	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS22630	COG0745	RESPONSE REGULATOR receiver
IGS71_RS22640	COG0076	glutamate decarboxylase activity
IGS71_RS22665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IGS71_RS22680	COG0037	tRNA processing
IGS71_RS22685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IGS71_RS22695	COG0302	gtp cyclohydrolase
IGS71_RS22710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IGS71_RS22750	COG0649	NAD binding
IGS71_RS22790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IGS71_RS22805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IGS71_RS22825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IGS71_RS22855	COG0739	heme binding
IGS71_RS22870	COG2205	protein histidine kinase activity
IGS71_RS22875	COG0745	RESPONSE REGULATOR receiver
IGS71_RS22885	COG1595	DNA-templated transcription, initiation
IGS71_RS22890	COG1194	a g-specific adenine glycosylase
IGS71_RS22900	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IGS71_RS22920	COG0248	Ppx GppA phosphatase
IGS71_RS22925	COG1082	Xylose isomerase domain protein TIM barrel
IGS71_RS22935	COG0129	dihydroxy-acid dehydratase activity
IGS71_RS22960	COG1129	ABC transporter
IGS71_RS22960	COG0842	Transport permease protein
IGS71_RS22970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IGS71_RS22975	COG0180	Tryptophanyl-tRNA synthetase
IGS71_RS22995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IGS71_RS23005	COG0123	including yeast histone deacetylase and acetoin utilization protein
IGS71_RS23055	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IGS71_RS23060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IGS71_RS23065	COG0181	hydroxymethylbilane synthase activity
IGS71_RS23070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS71_RS23070	COG1648	precorrin-2 dehydrogenase activity
IGS71_RS23080	COG0113	porphobilinogen synthase activity
IGS71_RS23115	COG0018	arginyl-trna synthetase
IGS71_RS23120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IGS71_RS23140	COG1690	Belongs to the RtcB family
IGS71_RS23155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS23170	COG0745	RESPONSE REGULATOR receiver
IGS71_RS23175	COG2205	protein histidine kinase activity
IGS71_RS23180	COG2326	polyphosphate kinase activity
IGS71_RS23185	COG1136	(ABC) transporter
IGS71_RS23235	COG1404	Belongs to the peptidase S8 family
IGS71_RS23250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IGS71_RS23255	COG0406	alpha-ribazole phosphatase activity
IGS71_RS23265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS71_RS23270	COG0785	Cytochrome C biogenesis protein
IGS71_RS23280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IGS71_RS23320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IGS71_RS23330	COG1609	Transcriptional regulator
IGS71_RS23350	COG0163	prenyltransferase activity
IGS71_RS23360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IGS71_RS23375	COG1309	transcriptional regulator
IGS71_RS23390	COG1278	Cold shock
IGS71_RS23395	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IGS71_RS23505	COG3209	COG3209 Rhs family protein
IGS71_RS23505	COG4104	PAAR repeat-containing protein
IGS71_RS23525	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IGS71_RS23575	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IGS71_RS23585	COG3979	chitinase
IGS71_RS23605	COG2226	methyltransferase
IGS71_RS23635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23645	COG0649	NAD binding
IGS71_RS23655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS71_RS23660	COG1034	ATP synthesis coupled electron transport
IGS71_RS23665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGS71_RS23670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23675	COG0839	Belongs to the complex I subunit 6 family
IGS71_RS23680	COG0713	ATP synthesis coupled electron transport
IGS71_RS23685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS71_RS23695	COG1007	ATP synthesis coupled electron transport
IGS71_RS23700	COG0514	ATP-dependent DNA helicase (RecQ)
IGS71_RS23710	COG0561	phosphatase activity
IGS71_RS23720	COG0142	geranyltranstransferase activity
IGS71_RS23730	COG1131	(ABC) transporter
IGS71_RS23765	COG0702	epimerase
IGS71_RS23770	COG1733	regulation of RNA biosynthetic process
IGS71_RS23775	COG1013	pyruvate-flavodoxin oxidoreductase activity
IGS71_RS23780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IGS71_RS23780	COG0674	pyruvate-flavodoxin oxidoreductase activity
IGS71_RS23800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGS71_RS23820	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS71_RS23825	COG0839	Belongs to the complex I subunit 6 family
IGS71_RS23830	COG0713	ATP synthesis coupled electron transport
IGS71_RS23835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS71_RS23845	COG1007	ATP synthesis coupled electron transport
IGS71_RS23850	COG0501	Belongs to the peptidase M48B family
IGS71_RS23855	COG3304	Inner membrane component domain
IGS71_RS23875	COG2261	transglycosylase associated protein
IGS71_RS23880	COG1666	GTP binding
IGS71_RS23890	COG0702	epimerase
IGS71_RS23900	COG0402	S-adenosylhomocysteine deaminase activity
IGS71_RS23915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS71_RS23920	COG2030	dehydratase
IGS71_RS23935	COG0477	Major facilitator Superfamily
IGS71_RS23940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IGS71_RS23945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS71_RS23950	COG0436	Aminotransferase
IGS71_RS23970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGS71_RS23975	COG0081	regulation of translation
IGS71_RS23990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGS71_RS23995	COG0222	ribosome binding
IGS71_RS24000	COG0085	RNA polymerase activity
IGS71_RS24005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGS71_RS24015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGS71_RS24020	COG0049	tRNA binding
IGS71_RS24025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS71_RS24030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS71_RS24075	COG3896	Chloramphenicol phosphotransferase-like protein
IGS71_RS24100	COG0051	transcription antitermination factor activity, RNA binding
IGS71_RS24105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGS71_RS24110	COG0088	Forms part of the polypeptide exit tunnel
IGS71_RS24115	COG0089	rRNA binding
IGS71_RS24120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGS71_RS24125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IGS71_RS24130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IGS71_RS24135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGS71_RS24140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGS71_RS24145	COG0255	Belongs to the universal ribosomal protein uL29 family
IGS71_RS24150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGS71_RS24155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGS71_RS24160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGS71_RS24165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGS71_RS24170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS71_RS24175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IGS71_RS24180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IGS71_RS24185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IGS71_RS24190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGS71_RS24195	COG1841	ribosomal large subunit assembly
IGS71_RS24200	COG0200	Binds to the 23S rRNA
IGS71_RS24210	COG0563	adenylate kinase activity
IGS71_RS24220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGS71_RS24225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IGS71_RS24230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGS71_RS24235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGS71_RS24240	COG0202	RNA polymerase activity
IGS71_RS24245	COG0203	ribosomal protein L17
IGS71_RS24250	COG0101	tRNA pseudouridine synthase activity
IGS71_RS24260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IGS71_RS24260	COG4124	Belongs to the glycosyl hydrolase 26 family
IGS71_RS24275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGS71_RS24290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGS71_RS24295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGS71_RS24300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS71_RS24320	COG1072	(Pantothenic acid kinase))
IGS71_RS24330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS71_RS24360	COG0736	holo-[acyl-carrier-protein] synthase activity
IGS71_RS24365	COG1733	regulation of RNA biosynthetic process
IGS71_RS24380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS71_RS24385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS24390	COG0802	atpase or kinase
IGS71_RS24400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGS71_RS24420	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS24430	COG1175	transmembrane transport
IGS71_RS24440	COG1609	Transcriptional regulator
IGS71_RS24445	COG1316	TRANSCRIPTIONal
IGS71_RS24460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGS71_RS24475	COG0667	Aldo Keto reductase
IGS71_RS24480	COG1316	TRANSCRIPTIONal
IGS71_RS24485	COG1316	TRANSCRIPTIONal
IGS71_RS24490	COG0463	Glycosyl transferase, family 2
IGS71_RS24495	COG1316	TRANSCRIPTIONal
IGS71_RS24500	COG1316	TRANSCRIPTIONal
IGS71_RS24505	COG1316	TRANSCRIPTIONal
IGS71_RS24530	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IGS71_RS24530	COG0778	Nitroreductase
IGS71_RS24535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IGS71_RS24570	COG1620	l-lactate permease
IGS71_RS24575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS71_RS24580	COG2835	tetraacyldisaccharide 4'-kinase activity
IGS71_RS24590	COG1482	cell wall glycoprotein biosynthetic process
IGS71_RS24600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IGS71_RS24640	COG0714	Associated with various cellular activities
IGS71_RS24665	COG0745	RESPONSE REGULATOR receiver
IGS71_RS24670	COG5000	phosphorelay sensor kinase activity
IGS71_RS24670	COG5002	protein histidine kinase activity
IGS71_RS24675	COG0823	Involved in the tonB-independent uptake of proteins
IGS71_RS24685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IGS71_RS24690	COG2197	response regulator
IGS71_RS24695	COG3214	Protein conserved in bacteria
IGS71_RS24705	COG0653	protein targeting
IGS71_RS24725	COG2902	Dehydrogenase
IGS71_RS24730	COG0463	Glycosyl transferase, family 2
IGS71_RS24730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS71_RS24735	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS24740	COG1134	teichoic acid transport
IGS71_RS24750	COG1309	transcriptional regulator
IGS71_RS24765	COG1215	transferase activity, transferring glycosyl groups
IGS71_RS24780	COG1846	Transcriptional regulator
IGS71_RS24785	COG1764	response to oxidative stress
IGS71_RS24795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS71_RS24800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS71_RS24805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS71_RS24805	COG0463	Glycosyl transferase, family 2
IGS71_RS24810	COG0395	ABC-type sugar transport system, permease component
IGS71_RS24815	COG1175	transmembrane transport
IGS71_RS24820	COG1653	transport
IGS71_RS24825	COG1674	ftsk spoiiie
IGS71_RS24830	COG0515	serine threonine protein kinase
IGS71_RS24835	COG0515	serine threonine protein kinase
IGS71_RS24840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IGS71_RS24855	COG2884	Cell division ATP-binding protein ftsE
IGS71_RS24865	COG0793	Belongs to the peptidase S41A family
IGS71_RS24870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGS71_RS24880	COG2027	D-alanyl-D-alanine carboxypeptidase
IGS71_RS24885	COG1609	Transcriptional regulator
IGS71_RS24890	COG1501	Belongs to the glycosyl hydrolase 31 family
IGS71_RS24895	COG0395	ABC-type sugar transport system, permease component
IGS71_RS24900	COG1175	transmembrane transport
IGS71_RS24905	COG1653	transport
IGS71_RS24915	COG0583	DNA-binding transcription factor activity
IGS71_RS24965	COG0539	negative regulation of cytoplasmic translation
IGS71_RS25005	COG2815	serine threonine protein kinase
IGS71_RS25005	COG0515	serine threonine protein kinase
IGS71_RS25035	COG2223	nitrite transmembrane transporter activity
IGS71_RS25060	COG3973	AAA domain
IGS71_RS25070	COG0776	regulation of translation
IGS71_RS25075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS71_RS25080	COG1678	Uncharacterized ACR, COG1678
IGS71_RS25095	COG1175	transmembrane transport
IGS71_RS25100	COG0395	ABC-type sugar transport system, permease component
IGS71_RS25105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IGS71_RS25120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS71_RS25145	COG3654	unkown
IGS71_RS25160	COG3480	Lon protease (S16) C-terminal proteolytic domain
IGS71_RS25170	COG1174	glycine betaine transport
IGS71_RS25180	COG1174	glycine betaine transport
IGS71_RS25190	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IGS71_RS25200	COG0277	FAD linked oxidase domain protein
IGS71_RS25235	COG1335	isochorismatase
IGS71_RS25245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IGS71_RS25255	COG1113	amino acid transport
IGS71_RS25280	COG1234	tRNA 3'-trailer cleavage
IGS71_RS25285	COG1263	PTS System
IGS71_RS25290	COG1263	PTS System
IGS71_RS25295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS71_RS25300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IGS71_RS25310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGS71_RS25350	COG2076	Multidrug Resistance protein
IGS71_RS25375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS71_RS25390	COG4555	ABC transporter
IGS71_RS25405	COG2733	membrane
IGS71_RS25410	COG2814	Major facilitator Superfamily
IGS71_RS25470	COG0778	Nitroreductase
IGS71_RS25475	COG1309	transcriptional regulator
IGS71_RS25550	COG3764	Sortase (surface protein transpeptidase)
IGS71_RS25560	COG0515	serine threonine protein kinase
IGS71_RS25560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS71_RS25575	COG0706	membrane insertase activity
IGS71_RS25585	COG4702	Belongs to the UPF0303 family
IGS71_RS25590	COG0673	inositol 2-dehydrogenase activity
IGS71_RS25655	COG3397	chitin binding
IGS71_RS25670	COG1126	abc transporter atp-binding protein
IGS71_RS25675	COG0765	amino acid transport
IGS71_RS25680	COG0765	amino acid transport
IGS71_RS25685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS71_RS25695	COG0154	amidase activity
IGS71_RS25715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS25765	COG0406	alpha-ribazole phosphatase activity
IGS71_RS25795	COG0745	RESPONSE REGULATOR receiver
IGS71_RS25805	COG3979	chitinase
IGS71_RS25830	COG0395	ABC-type sugar transport system, permease component
IGS71_RS25835	COG1175	transmembrane transport
IGS71_RS25855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IGS71_RS25870	COG0589	response to stress
IGS71_RS25875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS71_RS25905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IGS71_RS25910	COG0076	glutamate decarboxylase activity
IGS71_RS25940	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS25955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS71_RS25960	COG1309	transcriptional regulator
IGS71_RS25970	COG1946	Acyl-CoA thioesterase
IGS71_RS25985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS71_RS25995	COG0028	Belongs to the TPP enzyme family
IGS71_RS26005	COG2356	endonuclease I
IGS71_RS26015	COG1309	transcriptional regulator
IGS71_RS26020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IGS71_RS26100	COG5285	phytanoyl-CoA dioxygenase
IGS71_RS26110	COG2226	methyltransferase
IGS71_RS26155	COG2197	response regulator
IGS71_RS26185	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS26195	COG0456	acetyltransferase
IGS71_RS26195	COG1846	Transcriptional regulator
IGS71_RS26210	COG0673	inositol 2-dehydrogenase activity
IGS71_RS26245	COG1234	tRNA 3'-trailer cleavage
IGS71_RS26265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS26285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGS71_RS26320	COG3962	Belongs to the TPP enzyme family
IGS71_RS26340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IGS71_RS26390	COG0728	peptidoglycan biosynthetic process
IGS71_RS26405	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS26440	COG2304	oxidoreductase activity
IGS71_RS26450	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS26465	COG4221	oxidoreductase activity
IGS71_RS26470	COG0583	DNA-binding transcription factor activity
IGS71_RS26480	COG2205	protein histidine kinase activity
IGS71_RS26485	COG0745	RESPONSE REGULATOR receiver
IGS71_RS26495	COG1404	Belongs to the peptidase S8 family
IGS71_RS26535	COG0667	Aldo Keto reductase
IGS71_RS26540	COG0583	DNA-binding transcription factor activity
IGS71_RS26565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IGS71_RS26575	COG2801	Transposase and inactivated derivatives
IGS71_RS26585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS71_RS26590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS71_RS26595	COG0629	single-stranded DNA binding
IGS71_RS26645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS71_RS26675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS71_RS26690	COG1486	melibiose metabolic process
IGS71_RS26695	COG0395	ABC-type sugar transport system, permease component
IGS71_RS26700	COG1175	transmembrane transport
IGS71_RS26710	COG1940	carbohydrate kinase activity
IGS71_RS26775	COG0668	transmembrane transport
IGS71_RS26825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IGS71_RS26830	COG1120	ATPase activity
IGS71_RS26885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IGS71_RS26900	COG1116	anion transmembrane transporter activity
IGS71_RS26905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS26910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IGS71_RS26915	COG1940	carbohydrate kinase activity
IGS71_RS26925	COG1113	amino acid transport
IGS71_RS26955	COG4552	Acetyltransferase involved in intracellular survival and related
IGS71_RS26965	COG0475	glutathione-regulated potassium exporter activity
IGS71_RS26975	COG3594	Acyltransferase
IGS71_RS27000	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGS71_RS27005	COG0740	serine-type endopeptidase activity
IGS71_RS27010	COG0740	serine-type endopeptidase activity
IGS71_RS27015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGS71_RS27025	COG0525	valine-tRNA ligase activity
IGS71_RS27030	COG0285	dihydrofolate synthase activity
IGS71_RS27040	COG0105	UTP biosynthetic process
IGS71_RS27045	COG1077	Cell shape determining protein MreB Mrl
IGS71_RS27060	COG0768	penicillin binding
IGS71_RS27065	COG0772	Belongs to the SEDS family
IGS71_RS27095	COG1530	ribonuclease E activity
IGS71_RS27105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IGS71_RS27110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGS71_RS27115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS71_RS27125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IGS71_RS27135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGS71_RS27165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGS71_RS27175	COG0799	negative regulation of ribosome biogenesis
IGS71_RS27180	COG0588	phosphoglycerate mutase activity
IGS71_RS27195	COG0477	Major facilitator Superfamily
IGS71_RS27215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS71_RS27225	COG0495	leucyl-tRNA aminoacylation
IGS71_RS27235	COG1307	EDD domain protein, DegV family
IGS71_RS27240	COG1596	polysaccharide export
IGS71_RS27240	COG1555	photosystem II stabilization
IGS71_RS27255	COG2353	YceI-like domain
IGS71_RS27280	COG0477	Major facilitator Superfamily
IGS71_RS27290	COG0268	Binds directly to 16S ribosomal RNA
IGS71_RS27295	COG0481	GTPase activity
IGS71_RS27335	COG1420	regulation of RNA biosynthetic process
IGS71_RS27340	COG0484	heat shock protein binding
IGS71_RS27360	COG4946	Tricorn protease homolog
IGS71_RS27360	COG0793	Belongs to the peptidase S41A family
IGS71_RS27365	COG0537	adenosine 5'-monophosphoramidase activity
IGS71_RS27370	COG1234	tRNA 3'-trailer cleavage
IGS71_RS27375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS71_RS27380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS27390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IGS71_RS27400	COG2315	Protein conserved in bacteria
IGS71_RS27430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS71_RS27445	COG2723	6-phospho-beta-galactosidase activity
IGS71_RS27460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS71_RS27470	COG2409	Drug exporters of the RND superfamily
IGS71_RS27480	COG2197	response regulator
IGS71_RS27485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS71_RS27490	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS27495	COG0444	Belongs to the ABC transporter superfamily
IGS71_RS27505	COG0747	negative chemotaxis
IGS71_RS27525	COG1381	Involved in DNA repair and RecF pathway recombination
IGS71_RS27530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS71_RS27540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS71_RS27545	COG1120	ATPase activity
IGS71_RS27550	COG0803	Belongs to the bacterial solute-binding protein 9 family
IGS71_RS27550	COG3443	Belongs to the bacterial solute-binding protein 9 family
IGS71_RS27555	COG0423	glycine-tRNA ligase activity
IGS71_RS27570	COG0477	Major facilitator Superfamily
IGS71_RS27595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS71_RS27635	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IGS71_RS27640	COG1940	carbohydrate kinase activity
IGS71_RS27640	COG1846	Transcriptional regulator
IGS71_RS27645	COG0574	Belongs to the PEP-utilizing enzyme family
IGS71_RS27645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS71_RS27665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS71_RS27665	COG2146	nitrite reductase [NAD(P)H] activity
IGS71_RS27670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS71_RS27695	COG2124	cytochrome p450
IGS71_RS27715	COG1733	regulation of RNA biosynthetic process
IGS71_RS27720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGS71_RS27725	COG0243	molybdopterin cofactor binding
IGS71_RS27735	COG2949	membrane
IGS71_RS27755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IGS71_RS27765	COG0358	DNA primase activity
IGS71_RS27770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS71_RS27785	COG1070	Carbohydrate kinase
IGS71_RS27825	COG4941	Belongs to the sigma-70 factor family
IGS71_RS27835	COG3250	beta-galactosidase activity
IGS71_RS27840	COG2755	lipolytic protein G-D-S-L family
IGS71_RS27840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IGS71_RS27865	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS27880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGS71_RS27895	COG1077	Cell shape determining protein MreB Mrl
IGS71_RS27900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IGS71_RS27900	COG0825	malonyl-CoA metabolic process
IGS71_RS27905	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS27915	COG2186	Transcriptional regulator
IGS71_RS27920	COG3340	Belongs to the peptidase S51 family
IGS71_RS27970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS71_RS27980	COG4981	capsule polysaccharide biosynthetic process
IGS71_RS27985	COG0500	methyltransferase
IGS71_RS28010	COG1414	Transcriptional regulator
IGS71_RS28015	COG3386	PFAM SMP-30 Gluconolaconase
IGS71_RS28025	COG1175	transmembrane transport
IGS71_RS28030	COG0395	ABC-type sugar transport system, permease component
IGS71_RS28040	COG0730	response to heat
IGS71_RS28050	COG0583	DNA-binding transcription factor activity
IGS71_RS28065	COG3507	Belongs to the glycosyl hydrolase 43 family
IGS71_RS28070	COG3940	Belongs to the glycosyl hydrolase 43 family
IGS71_RS28075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS71_RS28085	COG4214	carbohydrate transport
IGS71_RS28110	COG4948	Mandelate Racemase Muconate Lactonizing
IGS71_RS28125	COG2130	NADP-dependent
IGS71_RS28160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS71_RS28165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS28170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS28185	COG1741	Belongs to the pirin family
IGS71_RS28200	COG4585	Histidine kinase
IGS71_RS28205	COG2197	response regulator
IGS71_RS28220	COG0789	Transcriptional regulator
IGS71_RS28225	COG0667	Aldo Keto reductase
IGS71_RS28240	COG1309	transcriptional regulator
IGS71_RS28245	COG0477	Major facilitator Superfamily
IGS71_RS28255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IGS71_RS28300	COG1358	cellular component organization or biogenesis
IGS71_RS28420	COG1309	transcriptional regulator
IGS71_RS28490	COG4122	O-methyltransferase activity
IGS71_RS28505	COG2124	cytochrome p450
IGS71_RS28510	COG0183	Belongs to the thiolase family
IGS71_RS28515	COG0702	epimerase
IGS71_RS28535	COG1562	ergosterol biosynthetic process
IGS71_RS28565	COG0640	Transcriptional regulator
IGS71_RS28570	COG2249	NAD(P)H dehydrogenase (quinone) activity
IGS71_RS28580	COG3845	ABC transporter
IGS71_RS28625	COG1309	transcriptional regulator
IGS71_RS28630	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS28665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS28675	COG2247	cell wall binding repeat
IGS71_RS28675	COG0860	N-Acetylmuramoyl-L-alanine amidase
IGS71_RS28695	COG2197	response regulator
IGS71_RS28700	COG4585	Histidine kinase
IGS71_RS28705	COG2030	dehydratase
IGS71_RS28730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IGS71_RS28745	COG0800	Aldolase
IGS71_RS28750	COG3022	response to hydroperoxide
IGS71_RS28770	COG0154	amidase activity
IGS71_RS28820	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IGS71_RS28825	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS28835	COG2130	NADP-dependent
IGS71_RS28850	COG0300	oxidoreductase activity
IGS71_RS28960	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS28975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS71_RS28985	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGS71_RS29025	COG2259	Doxx family
IGS71_RS29030	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS29035	COG3540	Alkaline phosphatase
IGS71_RS29045	COG2814	Major facilitator Superfamily
IGS71_RS29050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS71_RS29080	COG0672	)-iron permease
IGS71_RS29085	COG2837	iron assimilation
IGS71_RS29090	COG2822	iron ion transport
IGS71_RS29095	COG1120	ATPase activity
IGS71_RS29100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS29105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IGS71_RS29170	COG1994	Peptidase M50
IGS71_RS29190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IGS71_RS29195	COG0477	Major facilitator Superfamily
IGS71_RS29210	COG2814	Major facilitator Superfamily
IGS71_RS29215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS71_RS29215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IGS71_RS29235	COG1959	2 iron, 2 sulfur cluster binding
IGS71_RS29240	COG1017	nitric oxide dioxygenase activity
IGS71_RS29240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS71_RS29245	COG0174	glutamine synthetase
IGS71_RS29270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IGS71_RS29280	COG1609	Transcriptional regulator
IGS71_RS29285	COG1653	transport
IGS71_RS29290	COG1175	transmembrane transport
IGS71_RS29295	COG3833	ABC-type maltose transport systems, permease component
IGS71_RS29300	COG0366	Alpha amylase catalytic
IGS71_RS29355	COG2197	response regulator
IGS71_RS29360	COG4585	Histidine kinase
IGS71_RS29370	COG0745	RESPONSE REGULATOR receiver
IGS71_RS29410	COG0501	Belongs to the peptidase M48B family
IGS71_RS29415	COG0174	glutamine synthetase
IGS71_RS29440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IGS71_RS29445	COG0321	lipoyl(octanoyl) transferase activity
IGS71_RS29485	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS29495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IGS71_RS29505	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS71_RS29510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS71_RS29515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGS71_RS29520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IGS71_RS29530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS71_RS29570	COG4585	Histidine kinase
IGS71_RS29575	COG2197	response regulator
IGS71_RS29580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS71_RS29605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IGS71_RS29625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS29635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGS71_RS29640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS71_RS29650	COG1376	ErfK ybiS ycfS ynhG family protein
IGS71_RS29660	COG1845	cytochrome c oxidase, subunit III
IGS71_RS29665	COG2010	Cytochrome c
IGS71_RS29670	COG0723	plastoquinol--plastocyanin reductase activity
IGS71_RS29675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGS71_RS29680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS71_RS29685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS71_RS29750	COG0003	Pfam Anion-transporting ATPase
IGS71_RS29760	COG1940	carbohydrate kinase activity
IGS71_RS29785	COG4585	Histidine kinase
IGS71_RS29795	COG0205	6-phosphofructokinase activity
IGS71_RS29810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IGS71_RS29815	COG0243	molybdopterin cofactor binding
IGS71_RS29820	COG2193	ferroxidase activity
IGS71_RS29825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS71_RS29830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IGS71_RS29835	COG2815	serine threonine protein kinase
IGS71_RS29835	COG0515	serine threonine protein kinase
IGS71_RS29840	COG2022	thiamine diphosphate biosynthetic process
IGS71_RS29850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS71_RS29850	COG2022	thiamine diphosphate biosynthetic process
IGS71_RS29865	COG0352	thiamine-phosphate diphosphorylase activity
IGS71_RS29880	COG1233	COG1233 Phytoene dehydrogenase and related
IGS71_RS29890	COG1309	transcriptional regulator
IGS71_RS29900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS71_RS29920	COG0714	Associated with various cellular activities
IGS71_RS29930	COG0275	rRNA processing
IGS71_RS29945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGS71_RS29955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS71_RS29960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGS71_RS29970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS71_RS29975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IGS71_RS29980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IGS71_RS29985	COG1496	oxidoreductase activity
IGS71_RS29995	COG1799	cell septum assembly
IGS71_RS30005	COG3599	regulation of cell shape
IGS71_RS30010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGS71_RS30020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IGS71_RS30065	COG0587	DNA-directed DNA polymerase activity
IGS71_RS30075	COG1432	Conserved Protein
IGS71_RS30095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IGS71_RS30115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS71_RS30120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS71_RS30125	COG0131	Imidazoleglycerol-phosphate dehydratase
IGS71_RS30135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGS71_RS30140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IGS71_RS30145	COG0251	oxidation-reduction process
IGS71_RS30150	COG0107	imidazoleglycerol-phosphate synthase activity
IGS71_RS30195	COG0134	indole-3-glycerol-phosphate synthase activity
IGS71_RS30205	COG0133	tryptophan synthase activity
IGS71_RS30210	COG0159	tryptophan synthase activity
IGS71_RS30220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGS71_RS30230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS71_RS30260	COG0067	glutamate synthase
IGS71_RS30260	COG0069	glutamate synthase activity
IGS71_RS30260	COG0070	glutamate synthase
IGS71_RS30285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGS71_RS30295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS71_RS30305	COG1573	uracil-dna glycosylase
IGS71_RS30325	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS30340	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS30350	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS30355	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS30360	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS30365	COG1309	transcriptional regulator
IGS71_RS30370	COG0183	Belongs to the thiolase family
IGS71_RS30400	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS30415	COG4566	intracellular signal transduction
IGS71_RS30430	COG0737	Belongs to the 5'-nucleotidase family
IGS71_RS30480	COG2050	protein possibly involved in aromatic compounds catabolism
IGS71_RS30515	COG1643	Atp-dependent helicase
IGS71_RS30520	COG2226	methyltransferase
IGS71_RS30535	COG0237	dephospho-CoA kinase activity
IGS71_RS30555	COG2226	methyltransferase
IGS71_RS30575	COG2267	carboxylic ester hydrolase activity
IGS71_RS30580	COG1802	Transcriptional regulator
IGS71_RS30615	COG2197	response regulator
IGS71_RS30620	COG4585	Histidine kinase
IGS71_RS30635	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS30670	COG0402	S-adenosylhomocysteine deaminase activity
IGS71_RS30745	COG0598	Magnesium transport protein CorA
IGS71_RS30750	COG2226	methyltransferase
IGS71_RS30755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS30760	COG2313	pseudouridylate synthase activity
IGS71_RS30765	COG1063	alcohol dehydrogenase
IGS71_RS30770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS71_RS30775	COG0584	glycerophosphoryl diester phosphodiesterase
IGS71_RS30785	COG0556	nucleotide-excision repair
IGS71_RS30805	COG0387	Pfam Sodium calcium exchanger
IGS71_RS30810	COG0477	Major facilitator Superfamily
IGS71_RS30815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IGS71_RS30825	COG0765	amino acid transport
IGS71_RS30830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS71_RS30845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS71_RS30855	COG1609	Transcriptional regulator
IGS71_RS30870	COG0322	excinuclease ABC activity
IGS71_RS30875	COG1660	Displays ATPase and GTPase activities
IGS71_RS30880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IGS71_RS30885	COG1481	regulation of sporulation
IGS71_RS30895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IGS71_RS30900	COG0126	phosphoglycerate kinase activity
IGS71_RS30905	COG0149	triose-phosphate isomerase activity
IGS71_RS30910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IGS71_RS30920	COG0166	Belongs to the GPI family
IGS71_RS30925	COG0363	glucosamine-6-phosphate deaminase activity
IGS71_RS30940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS71_RS30950	COG0109	protoheme IX farnesyltransferase activity
IGS71_RS30970	COG1612	heme a metabolic process
IGS71_RS30980	COG1131	(ABC) transporter
IGS71_RS30985	COG2746	aminoglycoside 3-N-acetyltransferase activity
IGS71_RS31000	COG0719	Fe-S assembly protein
IGS71_RS31010	COG0396	ATPase activity
IGS71_RS31015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS71_RS31020	COG0822	iron-sulfur transferase activity
IGS71_RS31035	COG2076	Multidrug Resistance protein
IGS71_RS31040	COG3226	Transcriptional regulator
IGS71_RS31045	COG2171	N-acyltransferase activity
IGS71_RS31050	COG1595	DNA-templated transcription, initiation
IGS71_RS31060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS71_RS31080	COG0477	Major facilitator Superfamily
IGS71_RS31125	COG1063	alcohol dehydrogenase
IGS71_RS31130	COG0395	ABC-type sugar transport system, permease component
IGS71_RS31145	COG1349	DNA-binding transcription factor activity
IGS71_RS31150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS71_RS31155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS71_RS31175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS71_RS31205	COG1802	Transcriptional regulator
IGS71_RS31225	COG0395	ABC-type sugar transport system, permease component
IGS71_RS31245	COG1653	transport
IGS71_RS31250	COG2755	lipolytic protein G-D-S-L family
IGS71_RS31260	COG4677	pectinesterase activity
IGS71_RS31275	COG1595	DNA-templated transcription, initiation
IGS71_RS31280	COG2252	PERMEase
IGS71_RS31285	COG0768	penicillin binding
IGS71_RS31295	COG1414	Transcriptional regulator
IGS71_RS31310	COG0456	acetyltransferase
IGS71_RS31315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS71_RS31320	COG1917	Cupin 2, conserved barrel domain protein
IGS71_RS31325	COG5285	phytanoyl-CoA dioxygenase
IGS71_RS31330	COG1902	pentaerythritol trinitrate reductase activity
IGS71_RS31335	COG1846	Transcriptional regulator
IGS71_RS31350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IGS71_RS31360	COG0765	amino acid transport
IGS71_RS31380	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IGS71_RS31395	COG1797	cobyrinic acid a,c-diamide synthase activity
IGS71_RS31410	COG1492	cobalamin metabolic process
IGS71_RS31415	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IGS71_RS31430	COG0235	Class ii aldolase
IGS71_RS31450	COG0488	(ABC) transporter
IGS71_RS31480	COG3387	PFAM Glycoside hydrolase 15-related
IGS71_RS31495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS71_RS31545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS71_RS31550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS71_RS31570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGS71_RS31580	COG0312	modulator of DNA gyrase
IGS71_RS31595	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS31600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IGS71_RS31610	COG2186	Transcriptional regulator
IGS71_RS31625	COG0588	phosphoglycerate mutase activity
IGS71_RS31630	COG3830	Belongs to the UPF0237 family
IGS71_RS31630	COG0560	Phosphoserine phosphatase
IGS71_RS31640	COG1716	ATPase activity
IGS71_RS31640	COG1131	(ABC) transporter
IGS71_RS31640	COG0842	Transport permease protein
IGS71_RS31650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IGS71_RS31655	COG4221	oxidoreductase activity
IGS71_RS31660	COG4585	Histidine kinase
IGS71_RS31665	COG2197	response regulator
IGS71_RS31680	COG1119	ATPase activity
IGS71_RS31700	COG1881	PFAM PEBP family protein
IGS71_RS31710	COG2094	Belongs to the DNA glycosylase MPG family
IGS71_RS31740	COG0647	UMP catabolic process
IGS71_RS31745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS31750	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS31755	COG1120	ATPase activity
IGS71_RS31775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IGS71_RS31780	COG0497	DNA recombination
IGS71_RS31785	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS31790	COG3387	PFAM Glycoside hydrolase 15-related
IGS71_RS31800	COG0494	nUDIX hydrolase
IGS71_RS31810	COG0686	Belongs to the AlaDH PNT family
IGS71_RS31825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IGS71_RS31830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IGS71_RS31835	COG1187	pseudouridine synthase activity
IGS71_RS31845	COG1397	ADP-ribosylglycohydrolase
IGS71_RS31875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IGS71_RS31885	COG1160	GTP binding
IGS71_RS31905	COG1129	ABC transporter
IGS71_RS31925	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS31940	COG0671	phosphoesterase, PA-phosphatase related
IGS71_RS31950	COG0477	Major facilitator Superfamily
IGS71_RS31955	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS31960	COG1799	cell septum assembly
IGS71_RS31980	COG1126	abc transporter atp-binding protein
IGS71_RS31985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS71_RS32020	COG0587	DNA-directed DNA polymerase activity
IGS71_RS32060	COG1725	Transcriptional regulator
IGS71_RS32075	COG2755	lipolytic protein G-D-S-L family
IGS71_RS32080	COG2815	serine threonine protein kinase
IGS71_RS32080	COG0515	serine threonine protein kinase
IGS71_RS32100	COG1595	DNA-templated transcription, initiation
IGS71_RS32135	COG2188	Transcriptional regulator
IGS71_RS32140	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IGS71_RS32150	COG1309	transcriptional regulator
IGS71_RS32160	COG2851	Citrate transporter
IGS71_RS32170	COG3842	ATPase activity
IGS71_RS32190	COG0640	Transcriptional regulator
IGS71_RS32200	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS32245	COG3876	Protein conserved in bacteria
IGS71_RS32250	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS32255	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS32295	COG2149	membrane
IGS71_RS32300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IGS71_RS32310	COG3573	Dehydrogenase
IGS71_RS32330	COG1063	alcohol dehydrogenase
IGS71_RS32335	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS32345	COG3265	gluconokinase activity
IGS71_RS32350	COG2186	Transcriptional regulator
IGS71_RS32355	COG3012	SEC-C Motif Domain Protein
IGS71_RS32385	COG1222	aaa ATPase
IGS71_RS32460	COG0308	aminopeptidase N
IGS71_RS32470	COG1902	pentaerythritol trinitrate reductase activity
IGS71_RS32470	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS71_RS32500	COG2319	Wd-40 repeat
IGS71_RS32500	COG4249	Peptidase C14 caspase catalytic subunit p20
IGS71_RS32525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS71_RS32555	COG0667	Aldo Keto reductase
IGS71_RS32560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS32570	COG0598	Magnesium transport protein CorA
IGS71_RS32590	COG0215	cysteine-tRNA ligase activity
IGS71_RS32605	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IGS71_RS32610	COG1079	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS32620	COG3845	ABC transporter
IGS71_RS32630	COG0235	Class ii aldolase
IGS71_RS32630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IGS71_RS32635	COG0235	Class ii aldolase
IGS71_RS32640	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IGS71_RS32645	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IGS71_RS32655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IGS71_RS32660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS71_RS32665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IGS71_RS32670	COG1414	Transcriptional regulator
IGS71_RS32675	COG0646	methionine synthase
IGS71_RS32675	COG1410	methionine synthase
IGS71_RS32685	COG4166	transmembrane transport
IGS71_RS32690	COG2197	response regulator
IGS71_RS32700	COG0517	IMP dehydrogenase activity
IGS71_RS32700	COG1994	Peptidase M50
IGS71_RS32720	COG1222	aaa ATPase
IGS71_RS32725	COG4122	O-methyltransferase activity
IGS71_RS32740	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IGS71_RS32745	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IGS71_RS32750	COG1609	Transcriptional regulator
IGS71_RS32760	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IGS71_RS32795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS71_RS32800	COG0805	protein transport
IGS71_RS32835	COG0564	pseudouridine synthase activity
IGS71_RS32845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS71_RS32850	COG0517	IMP dehydrogenase activity
IGS71_RS32850	COG4175	Glycine betaine
IGS71_RS32855	COG4176	ABC-type proline glycine betaine transport system permease component
IGS71_RS32875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGS71_RS32880	COG2186	Transcriptional regulator
IGS71_RS32885	COG0174	glutamine synthetase
IGS71_RS32890	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS32895	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS32935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGS71_RS32940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGS71_RS32945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGS71_RS32950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS71_RS32955	COG5002	protein histidine kinase activity
IGS71_RS32960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGS71_RS32965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS71_RS32965	COG0072	phenylalanine-tRNA ligase activity
IGS71_RS32995	COG1649	PFAM Uncharacterised BCR, COG1649
IGS71_RS33005	COG0697	spore germination
IGS71_RS33040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGS71_RS33045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IGS71_RS33050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGS71_RS33055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS71_RS33060	COG1438	arginine binding
IGS71_RS33095	COG0165	Argininosuccinate lyase
IGS71_RS33110	COG0477	Major facilitator Superfamily
IGS71_RS33115	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS33115	COG0204	Acyl-transferase
IGS71_RS33150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGS71_RS33155	COG2011	ABC-type metal ion transport system permease component
IGS71_RS33160	COG1464	Belongs to the NlpA lipoprotein family
IGS71_RS33165	COG1464	Belongs to the NlpA lipoprotein family
IGS71_RS33180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS71_RS33185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS71_RS33185	COG1648	precorrin-2 dehydrogenase activity
IGS71_RS33245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGS71_RS33300	COG1175	transmembrane transport
IGS71_RS33305	COG0395	ABC-type sugar transport system, permease component
IGS71_RS33335	COG5002	protein histidine kinase activity
IGS71_RS33335	COG2176	DNA-directed DNA polymerase activity
IGS71_RS33340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS71_RS33365	COG1560	Kdo2-lipid A biosynthetic process
IGS71_RS33370	COG0438	transferase activity, transferring glycosyl groups
IGS71_RS33380	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IGS71_RS33385	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IGS71_RS33390	COG0217	transcriptional regulatory protein
IGS71_RS33395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IGS71_RS33400	COG0632	four-way junction helicase activity
IGS71_RS33405	COG2255	four-way junction helicase activity
IGS71_RS33415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS71_RS33420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS71_RS33425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGS71_RS33430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IGS71_RS33435	COG1196	nuclear chromosome segregation
IGS71_RS33440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IGS71_RS33450	COG0124	histidyl-tRNA synthetase
IGS71_RS33465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGS71_RS33485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS71_RS33490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGS71_RS33495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IGS71_RS33500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS71_RS33505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGS71_RS33510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGS71_RS33515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS71_RS33525	COG0006	proline dipeptidase activity
IGS71_RS33530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IGS71_RS33535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS71_RS33545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IGS71_RS33550	COG0540	Belongs to the ATCase OTCase family
IGS71_RS33555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS71_RS33565	COG0505	Belongs to the CarA family
IGS71_RS33570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS71_RS33575	COG0167	dihydroorotate dehydrogenase activity
IGS71_RS33580	COG0284	orotidine-5'-phosphate decarboxylase activity
IGS71_RS33590	COG0194	GDP metabolic process
IGS71_RS33605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGS71_RS33620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS71_RS33630	COG2409	Drug exporters of the RND superfamily
IGS71_RS33635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IGS71_RS33640	COG2390	Transcriptional regulator
IGS71_RS33715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS71_RS33735	COG2233	PERMEase
IGS71_RS33740	COG0738	Major facilitator superfamily
IGS71_RS33745	COG1940	carbohydrate kinase activity
IGS71_RS33745	COG1846	Transcriptional regulator
IGS71_RS33755	COG3201	nicotinamide mononucleotide transporter
IGS71_RS33760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS71_RS33760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS71_RS33765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IGS71_RS33770	COG0140	phosphoribosyl-ATP diphosphatase activity
IGS71_RS33775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IGS71_RS33815	COG1309	transcriptional regulator
IGS71_RS33825	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS33835	COG1522	sequence-specific DNA binding
IGS71_RS33845	COG0463	Glycosyl transferase, family 2
IGS71_RS33850	COG3030	protein affecting phage T7 exclusion by the F plasmid
IGS71_RS33860	COG2270	Major facilitator Superfamily
IGS71_RS33870	COG2364	Membrane
IGS71_RS33875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS71_RS33900	COG1984	allophanate hydrolase subunit 2
IGS71_RS33905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IGS71_RS33910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IGS71_RS33915	COG4336	lyase activity
IGS71_RS33920	COG2814	Major facilitator Superfamily
IGS71_RS33950	COG0531	amino acid
IGS71_RS33955	COG4638	Rieske (2fe-2S)
IGS71_RS33960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS71_RS33975	COG1414	Transcriptional regulator
IGS71_RS33990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS71_RS34005	COG2018	Roadblock/LC7 domain
IGS71_RS34020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS71_RS34025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IGS71_RS34030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS34040	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IGS71_RS34055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS71_RS34065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS71_RS34095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGS71_RS34135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGS71_RS34145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS71_RS34145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS71_RS34175	COG0384	phenazine biosynthesis protein PhzF
IGS71_RS34180	COG1695	Transcriptional regulator
IGS71_RS34210	COG0697	spore germination
IGS71_RS34240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS34240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS71_RS34240	COG1703	isobutyryl-CoA mutase activity
IGS71_RS34330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IGS71_RS34345	COG2318	DinB family
IGS71_RS34355	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS71_RS34370	COG3631	Ketosteroid isomerase-related protein
IGS71_RS34375	COG0702	epimerase
IGS71_RS34390	COG1968	undecaprenyl-diphosphatase activity
IGS71_RS34420	COG2226	methyltransferase
IGS71_RS34475	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS34490	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS34510	COG1064	alcohol dehydrogenase
IGS71_RS34525	COG1968	undecaprenyl-diphosphatase activity
IGS71_RS34550	COG2409	Drug exporters of the RND superfamily
IGS71_RS34555	COG4585	Histidine kinase
IGS71_RS34560	COG2197	response regulator
IGS71_RS34570	COG2807	transmembrane transport
IGS71_RS34575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS71_RS34635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS71_RS34645	COG3718	enzyme involved in inositol metabolism
IGS71_RS34650	COG3962	Belongs to the TPP enzyme family
IGS71_RS34660	COG2188	Transcriptional regulator
IGS71_RS34670	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS34685	COG0110	maltose O-acetyltransferase activity
IGS71_RS34705	COG1832	CoA-binding protein
IGS71_RS34715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS71_RS34720	COG1120	ATPase activity
IGS71_RS34735	COG1739	Uncharacterized protein family UPF0029
IGS71_RS34745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS71_RS34750	COG3384	dioxygenase
IGS71_RS34765	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS34770	COG1414	Transcriptional regulator
IGS71_RS34785	COG0420	3'-5' exonuclease activity
IGS71_RS34790	COG0419	ATPase involved in DNA repair
IGS71_RS34810	COG0626	cystathionine gamma-synthase activity
IGS71_RS34835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS71_RS34850	COG1595	DNA-templated transcription, initiation
IGS71_RS34855	COG2188	Transcriptional regulator
IGS71_RS34860	COG1940	carbohydrate kinase activity
IGS71_RS34865	COG2197	response regulator
IGS71_RS34870	COG4585	Histidine kinase
IGS71_RS34890	COG3663	DNA glycosylase
IGS71_RS34895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS71_RS35005	COG0456	acetyltransferase
IGS71_RS35015	COG1136	(ABC) transporter
IGS71_RS35015	COG0577	efflux transmembrane transporter activity
IGS71_RS35035	COG2226	methyltransferase
IGS71_RS35040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IGS71_RS35045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS71_RS35050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGS71_RS35090	COG0740	serine-type endopeptidase activity
IGS71_RS35100	COG2084	Dehydrogenase
IGS71_RS35105	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS35110	COG3962	Belongs to the TPP enzyme family
IGS71_RS35120	COG0673	inositol 2-dehydrogenase activity
IGS71_RS35130	COG1082	Xylose isomerase domain protein TIM barrel
IGS71_RS35160	COG0673	inositol 2-dehydrogenase activity
IGS71_RS35170	COG0673	inositol 2-dehydrogenase activity
IGS71_RS35175	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS35205	COG1309	transcriptional regulator
IGS71_RS35210	COG0831	urea catabolic process
IGS71_RS35215	COG0832	Belongs to the urease beta subunit family
IGS71_RS35220	COG0804	urea catabolic process
IGS71_RS35230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IGS71_RS35235	COG0829	nickel cation binding
IGS71_RS35250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS71_RS35255	COG1834	amidinotransferase
IGS71_RS35260	COG1522	sequence-specific DNA binding
IGS71_RS35265	COG3279	Response regulator of the LytR AlgR family
IGS71_RS35275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS71_RS35280	COG3275	phosphorelay sensor kinase activity
IGS71_RS35295	COG0205	6-phosphofructokinase activity
IGS71_RS35300	COG3442	glutamine amidotransferase
IGS71_RS35310	COG0242	peptide deformylase activity
IGS71_RS35320	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS35330	COG2124	cytochrome p450
IGS71_RS35335	COG3424	synthase
IGS71_RS35350	COG0494	nUDIX hydrolase
IGS71_RS35355	COG1793	dna ligase
IGS71_RS35375	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS35380	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS35410	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS35415	COG0667	Aldo Keto reductase
IGS71_RS35425	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS35435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS35440	COG0601	transmembrane transport
IGS71_RS35445	COG4166	transmembrane transport
IGS71_RS35450	COG4948	Mandelate Racemase Muconate Lactonizing
IGS71_RS35455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS71_RS35460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS71_RS35470	COG1120	ATPase activity
IGS71_RS35475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IGS71_RS35485	COG1595	DNA-templated transcription, initiation
IGS71_RS35535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS71_RS35540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS71_RS35550	COG1120	ATPase activity
IGS71_RS35555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS71_RS35565	COG0803	Belongs to the bacterial solute-binding protein 9 family
IGS71_RS35580	COG0129	dihydroxy-acid dehydratase activity
IGS71_RS35590	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS35605	COG1175	transmembrane transport
IGS71_RS35615	COG1609	Transcriptional regulator
IGS71_RS35620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS71_RS35645	COG0477	Major facilitator Superfamily
IGS71_RS35670	COG1012	belongs to the aldehyde dehydrogenase family
IGS71_RS35685	COG1940	carbohydrate kinase activity
IGS71_RS35690	COG1070	Carbohydrate kinase
IGS71_RS35710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS71_RS35715	COG3239	Fatty acid desaturase
IGS71_RS35745	COG2018	Roadblock/LC7 domain
IGS71_RS35755	COG1946	Acyl-CoA thioesterase
IGS71_RS35770	COG0254	rRNA binding
IGS71_RS35780	COG1132	(ABC) transporter
IGS71_RS35805	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IGS71_RS35815	COG1132	(ABC) transporter
IGS71_RS35830	COG1116	anion transmembrane transporter activity
IGS71_RS35835	COG0432	Pfam Uncharacterised protein family UPF0047
IGS71_RS35860	COG1024	Enoyl-CoA hydratase
IGS71_RS35920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGS71_RS35935	COG1116	anion transmembrane transporter activity
IGS71_RS35950	COG2159	amidohydrolase
IGS71_RS35955	COG0028	Belongs to the TPP enzyme family
IGS71_RS36000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS71_RS36005	COG2706	6-phosphogluconolactonase activity
IGS71_RS36050	COG0596	Alpha beta hydrolase
IGS71_RS36060	COG2132	Multicopper oxidase
IGS71_RS36075	COG1819	glycosyl
IGS71_RS36110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS71_RS36135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS36145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS71_RS36150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS71_RS36155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS36160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IGS71_RS36160	COG0825	malonyl-CoA metabolic process
IGS71_RS36165	COG0511	ligase activity, forming carbon-carbon bonds
IGS71_RS36170	COG0439	Biotin carboxylase
IGS71_RS36195	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS36205	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IGS71_RS36210	COG2226	methyltransferase
IGS71_RS36210	COG2867	negative regulation of translational initiation
IGS71_RS36230	COG2867	negative regulation of translational initiation
IGS71_RS36235	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS36255	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IGS71_RS36265	COG2197	response regulator
IGS71_RS36270	COG4585	Histidine kinase
IGS71_RS36275	COG2409	Drug exporters of the RND superfamily
IGS71_RS36280	COG1619	proteins homologs of microcin C7 resistance protein MccF
IGS71_RS36335	COG2080	2 iron, 2 sulfur cluster binding
IGS71_RS36340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IGS71_RS36345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS71_RS36355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGS71_RS36365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS71_RS36370	COG3396	Phenylacetate-CoA oxygenase
IGS71_RS36375	COG3460	Phenylacetate-CoA oxygenase
IGS71_RS36380	COG3396	Phenylacetate-CoA oxygenase
IGS71_RS36385	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS71_RS36390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS71_RS36430	COG2971	BadF BadG BcrA BcrD
IGS71_RS36435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IGS71_RS36455	COG1902	pentaerythritol trinitrate reductase activity
IGS71_RS36460	COG0640	Transcriptional regulator
IGS71_RS36485	COG1309	transcriptional regulator
IGS71_RS36495	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS36500	COG4221	oxidoreductase activity
IGS71_RS36520	COG3864	Putative metallopeptidase domain
IGS71_RS36525	COG0714	Associated with various cellular activities
IGS71_RS36545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGS71_RS36545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IGS71_RS36565	COG0671	phosphoesterase, PA-phosphatase related
IGS71_RS36590	COG0248	Ppx GppA phosphatase
IGS71_RS36605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS36615	COG0243	molybdopterin cofactor binding
IGS71_RS36615	COG3383	formate dehydrogenase (NAD+) activity
IGS71_RS36620	COG0437	4 iron, 4 sulfur cluster binding
IGS71_RS36650	COG0584	glycerophosphoryl diester phosphodiesterase
IGS71_RS36670	COG0204	Acyl-transferase
IGS71_RS36695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IGS71_RS36710	COG0515	serine threonine protein kinase
IGS71_RS36735	COG1660	Displays ATPase and GTPase activities
IGS71_RS36745	COG0445	tRNA wobble uridine modification
IGS71_RS36750	COG4585	Histidine kinase
IGS71_RS36755	COG2197	response regulator
IGS71_RS36780	COG2226	methyltransferase
IGS71_RS36780	COG1073	alpha beta
IGS71_RS36790	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IGS71_RS36795	COG2301	Belongs to the HpcH HpaI aldolase family
IGS71_RS36805	COG2223	nitrite transmembrane transporter activity
IGS71_RS36825	COG3290	protein histidine kinase activity
IGS71_RS36830	COG4565	transcriptional regulatory protein
IGS71_RS36835	COG2813	Specifically methylates the guanine in position
IGS71_RS36845	COG1940	carbohydrate kinase activity
IGS71_RS36875	COG1349	DNA-binding transcription factor activity
IGS71_RS36885	COG0464	growth
IGS71_RS36910	COG1215	transferase activity, transferring glycosyl groups
IGS71_RS36915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IGS71_RS36935	COG0494	nUDIX hydrolase
IGS71_RS36940	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS36960	COG5002	protein histidine kinase activity
IGS71_RS36990	COG2119	membrane
IGS71_RS37005	COG1175	transmembrane transport
IGS71_RS37035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGS71_RS37040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGS71_RS37045	COG2186	Transcriptional regulator
IGS71_RS37055	COG2066	Belongs to the glutaminase family
IGS71_RS37060	COG1686	Belongs to the peptidase S11 family
IGS71_RS37065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IGS71_RS37085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IGS71_RS37090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IGS71_RS37100	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IGS71_RS37105	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IGS71_RS37110	COG0598	Magnesium transport protein CorA
IGS71_RS37135	COG3458	cephalosporin-C deacetylase activity
IGS71_RS37145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IGS71_RS37150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS71_RS37155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS71_RS37160	COG3321	synthase
IGS71_RS37160	COG0604	alcohol dehydrogenase
IGS71_RS37175	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS71_RS37180	COG1902	pentaerythritol trinitrate reductase activity
IGS71_RS37180	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS71_RS37210	COG1461	Dihydroxyacetone kinase
IGS71_RS37215	COG2376	Dihydroxyacetone kinase
IGS71_RS37230	COG3903	Transcriptional regulator
IGS71_RS37230	COG3629	intracellular signal transduction
IGS71_RS37255	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS37260	COG0515	serine threonine protein kinase
IGS71_RS37270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS71_RS37275	COG2070	2-Nitropropane dioxygenase
IGS71_RS37285	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS37345	COG0019	diaminopimelate decarboxylase activity
IGS71_RS37360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS71_RS37410	COG3594	Acyltransferase
IGS71_RS37435	COG0583	DNA-binding transcription factor activity
IGS71_RS37445	COG0431	NADPH-dependent FMN reductase
IGS71_RS37455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS37470	COG0753	catalase activity
IGS71_RS37505	COG0412	Dienelactone hydrolase
IGS71_RS37510	COG0583	DNA-binding transcription factor activity
IGS71_RS37515	COG0667	Aldo Keto reductase
IGS71_RS37545	COG0596	Alpha beta hydrolase
IGS71_RS37555	COG1132	(ABC) transporter
IGS71_RS37570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS37585	COG3226	Transcriptional regulator
IGS71_RS37610	COG0395	ABC-type sugar transport system, permease component
IGS71_RS37615	COG1175	transmembrane transport
IGS71_RS37625	COG4821	SIS domain
IGS71_RS37635	COG2188	Transcriptional regulator
IGS71_RS37640	COG0740	serine-type endopeptidase activity
IGS71_RS37645	COG0740	serine-type endopeptidase activity
IGS71_RS37660	COG2340	Cysteine-rich secretory protein family
IGS71_RS37665	COG0583	DNA-binding transcription factor activity
IGS71_RS37680	COG4221	oxidoreductase activity
IGS71_RS37685	COG0667	Aldo Keto reductase
IGS71_RS37700	COG1228	amidohydrolase
IGS71_RS37750	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS71_RS37760	COG1982	Orn Lys Arg decarboxylase major
IGS71_RS37775	COG0842	Transport permease protein
IGS71_RS37775	COG1131	(ABC) transporter
IGS71_RS37775	COG1716	ATPase activity
IGS71_RS37825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS71_RS37830	COG3281	Trehalose synthase
IGS71_RS37840	COG0366	Alpha amylase catalytic
IGS71_RS37915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS71_RS37920	COG1846	Transcriptional regulator
IGS71_RS37935	COG0784	Response regulator, receiver
IGS71_RS37935	COG2205	protein histidine kinase activity
IGS71_RS37935	COG5002	protein histidine kinase activity
IGS71_RS37940	COG1191	sigma factor activity
IGS71_RS37950	COG0783	Belongs to the Dps family
IGS71_RS37985	COG0395	ABC-type sugar transport system, permease component
IGS71_RS37990	COG1175	transmembrane transport
IGS71_RS37995	COG1609	Transcriptional regulator
IGS71_RS38015	COG0156	8-amino-7-oxononanoate synthase activity
IGS71_RS38050	COG1653	transport
IGS71_RS38135	COG1295	ribonuclease BN
IGS71_RS38165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS71_RS38220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS71_RS38225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS71_RS38240	COG1132	(ABC) transporter
IGS71_RS38245	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS71_RS38255	COG1129	ABC transporter
IGS71_RS38260	COG1879	ABC-type sugar transport system periplasmic component
IGS71_RS38265	COG1609	Transcriptional regulator
IGS71_RS38275	COG0492	ferredoxin-NADP+ reductase activity
IGS71_RS38290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS71_RS38310	COG0500	methyltransferase
IGS71_RS38320	COG3321	synthase
IGS71_RS38320	COG0604	alcohol dehydrogenase
IGS71_RS38325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS38330	COG0156	8-amino-7-oxononanoate synthase activity
IGS71_RS38335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS38340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS38345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS71_RS38350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS71_RS38355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS71_RS38360	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IGS71_RS38390	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS38400	COG3629	intracellular signal transduction
IGS71_RS38405	COG0702	epimerase
IGS71_RS38420	COG4608	Belongs to the ABC transporter superfamily
IGS71_RS38425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS71_RS38440	COG0747	negative chemotaxis
IGS71_RS38460	COG0395	ABC-type sugar transport system, permease component
IGS71_RS38465	COG1175	transmembrane transport
IGS71_RS38475	COG2188	Transcriptional regulator
IGS71_RS38490	COG0110	maltose O-acetyltransferase activity
IGS71_RS38495	COG3226	Transcriptional regulator
IGS71_RS38500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS71_RS38505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS71_RS38515	COG3655	Transcriptional regulator
IGS71_RS38540	COG0714	Associated with various cellular activities
IGS71_RS38585	COG2226	methyltransferase
IGS71_RS38595	COG4941	Belongs to the sigma-70 factor family
IGS71_RS38600	COG3795	YCII-related domain
IGS71_RS38605	COG2318	DinB family
IGS71_RS38610	COG2813	Specifically methylates the guanine in position
IGS71_RS38615	COG0477	Major facilitator Superfamily
IGS71_RS38625	COG0583	DNA-binding transcription factor activity
IGS71_RS38685	COG0395	ABC-type sugar transport system, permease component
IGS71_RS38715	COG2124	cytochrome p450
IGS71_RS38720	COG2124	cytochrome p450
IGS71_RS38775	COG1335	isochorismatase
IGS71_RS38780	COG0477	Major facilitator Superfamily
IGS71_RS38790	COG1335	isochorismatase
IGS71_RS38800	COG0515	serine threonine protein kinase
IGS71_RS38800	COG2815	serine threonine protein kinase
IGS71_RS38815	COG2814	Major facilitator Superfamily
IGS71_RS38845	COG0395	ABC-type sugar transport system, permease component
IGS71_RS38855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS71_RS38870	COG0583	DNA-binding transcription factor activity
IGS71_RS38875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS71_RS38895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS71_RS38900	COG0366	Alpha amylase catalytic
IGS71_RS38905	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS71_RS38915	COG1609	Transcriptional regulator
IGS71_RS38920	COG0395	ABC-type sugar transport system, permease component
IGS71_RS38925	COG1175	transmembrane transport
IGS71_RS38940	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS38965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS71_RS38985	COG0745	RESPONSE REGULATOR receiver
IGS71_RS38995	COG4221	oxidoreductase activity
IGS71_RS39000	COG1396	sequence-specific DNA binding
IGS71_RS39005	COG4977	sequence-specific DNA binding
IGS71_RS39030	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS39045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IGS71_RS39055	COG0024	Methionine aminopeptidase
IGS71_RS39060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS71_RS39065	COG0798	PFAM Bile acid sodium symporter
IGS71_RS39070	COG0640	Transcriptional regulator
IGS71_RS39075	COG2226	methyltransferase
IGS71_RS39090	COG3848	Pyruvate phosphate dikinase
IGS71_RS39090	COG0574	Belongs to the PEP-utilizing enzyme family
IGS71_RS39110	COG1660	Displays ATPase and GTPase activities
IGS71_RS39115	COG3345	alpha-galactosidase
IGS71_RS39135	COG2353	YceI-like domain
IGS71_RS39160	COG0586	Pfam SNARE associated Golgi protein
IGS71_RS39165	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS71_RS39205	COG0531	amino acid
IGS71_RS39210	COG1082	Xylose isomerase domain protein TIM barrel
IGS71_RS39225	COG0745	RESPONSE REGULATOR receiver
IGS71_RS39230	COG2205	protein histidine kinase activity
IGS71_RS39250	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39265	COG1073	alpha beta
IGS71_RS39275	COG1063	alcohol dehydrogenase
IGS71_RS39285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS39290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGS71_RS39325	COG0145	ligase activity
IGS71_RS39335	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS71_RS39395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS71_RS39405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS71_RS39410	COG0596	Alpha beta hydrolase
IGS71_RS39430	COG0145	ligase activity
IGS71_RS39450	COG0346	lactoylglutathione lyase activity
IGS71_RS39475	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IGS71_RS39495	COG0765	amino acid transport
IGS71_RS39525	COG2814	Major facilitator Superfamily
IGS71_RS39535	COG2936	dipeptidyl-peptidase activity
IGS71_RS39550	COG2318	DinB family
IGS71_RS39575	COG2197	response regulator
IGS71_RS39600	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IGS71_RS39650	COG1733	regulation of RNA biosynthetic process
IGS71_RS39675	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39695	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39720	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IGS71_RS39720	COG1672	PFAM Archaeal ATPase
IGS71_RS39725	COG0604	alcohol dehydrogenase
IGS71_RS39800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS71_RS39840	COG2197	response regulator
IGS71_RS39855	COG0515	serine threonine protein kinase
IGS71_RS39855	COG2815	serine threonine protein kinase
IGS71_RS39860	COG1940	carbohydrate kinase activity
IGS71_RS39865	COG4214	carbohydrate transport
IGS71_RS39875	COG4213	ABC transporter substrate-binding protein
IGS71_RS39880	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39890	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39900	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS39910	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS39935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS71_RS39960	COG1733	regulation of RNA biosynthetic process
IGS71_RS39985	COG3119	arylsulfatase activity
IGS71_RS40015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IGS71_RS40025	COG0745	RESPONSE REGULATOR receiver
IGS71_RS40035	COG2986	histidine ammonia-lyase
IGS71_RS40040	COG0492	ferredoxin-NADP+ reductase activity
IGS71_RS40055	COG0475	glutathione-regulated potassium exporter activity
IGS71_RS40065	COG0318	PFAM AMP-dependent synthetase and ligase
IGS71_RS40105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IGS71_RS40110	COG1846	Transcriptional regulator
IGS71_RS40120	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IGS71_RS40125	COG0726	polysaccharide deacetylase
IGS71_RS40130	COG0477	Major facilitator Superfamily
IGS71_RS40135	COG0726	polysaccharide deacetylase
IGS71_RS40160	COG2843	Capsule synthesis protein
IGS71_RS40165	COG1473	amidohydrolase
IGS71_RS40190	COG2267	carboxylic ester hydrolase activity
IGS71_RS40235	COG1595	DNA-templated transcription, initiation
IGS71_RS40275	COG0583	DNA-binding transcription factor activity
IGS71_RS40395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS71_RS40405	COG3572	ergothioneine biosynthetic process
IGS71_RS40415	COG1028	Short-chain dehydrogenase reductase Sdr
IGS71_RS40420	COG0583	DNA-binding transcription factor activity
IGS71_RS40425	COG0640	Transcriptional regulator
IGS71_RS40445	COG0640	Transcriptional regulator
IGS71_RS40470	COG1309	transcriptional regulator
IGS71_RS40505	COG1960	acyl-CoA dehydrogenase activity
IGS71_RS40510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS71_RS40515	COG2813	Specifically methylates the guanine in position
IGS71_RS40530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3