locus-tag	class	description
AVL59_RS00010	COG0592	DNA-directed DNA polymerase activity
AVL59_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AVL59_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVL59_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AVL59_RS00030	COG0187	DNA topoisomerase II activity
AVL59_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVL59_RS00050	COG2319	Wd-40 repeat
AVL59_RS00050	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL59_RS00085	COG0515	serine threonine protein kinase
AVL59_RS00100	COG0583	DNA-binding transcription factor activity
AVL59_RS00110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS00135	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVL59_RS00160	COG2814	Major facilitator Superfamily
AVL59_RS00180	COG1803	Methylglyoxal synthase
AVL59_RS00185	COG1902	pentaerythritol trinitrate reductase activity
AVL59_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS00210	COG0705	Rhomboid family
AVL59_RS00225	COG3764	Sortase (surface protein transpeptidase)
AVL59_RS00235	COG3764	Sortase (surface protein transpeptidase)
AVL59_RS00240	COG3764	Sortase (surface protein transpeptidase)
AVL59_RS00245	COG0515	serine threonine protein kinase
AVL59_RS00250	COG0768	penicillin binding
AVL59_RS00265	COG1716	ATPase activity
AVL59_RS00270	COG1716	ATPase activity
AVL59_RS00285	COG2197	response regulator
AVL59_RS00290	COG4585	Histidine kinase
AVL59_RS00335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVL59_RS00340	COG2151	metal-sulfur cluster biosynthetic enzyme
AVL59_RS00345	COG3396	Phenylacetate-CoA oxygenase
AVL59_RS00350	COG3460	Phenylacetate-CoA oxygenase
AVL59_RS00355	COG3396	Phenylacetate-CoA oxygenase
AVL59_RS00380	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL59_RS00385	COG1309	transcriptional regulator
AVL59_RS00390	COG1522	sequence-specific DNA binding
AVL59_RS00410	COG0746	molybdenum cofactor guanylyltransferase activity
AVL59_RS00425	COG0604	alcohol dehydrogenase
AVL59_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS00425	COG3321	synthase
AVL59_RS00440	COG0515	serine threonine protein kinase
AVL59_RS00445	COG0515	serine threonine protein kinase
AVL59_RS00460	COG0022	dehydrogenase e1 component
AVL59_RS00465	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL59_RS00555	COG1725	Transcriptional regulator
AVL59_RS00570	COG2814	Major facilitator Superfamily
AVL59_RS00610	COG1362	aminopeptidase activity
AVL59_RS00615	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS00625	COG1741	Belongs to the pirin family
AVL59_RS00675	COG2409	Drug exporters of the RND superfamily
AVL59_RS00685	COG3963	phosphatidate phosphatase activity
AVL59_RS00725	COG2030	dehydratase
AVL59_RS00735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS00740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS00745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVL59_RS00750	COG1233	COG1233 Phytoene dehydrogenase and related
AVL59_RS00770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVL59_RS00795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL59_RS00800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL59_RS00810	COG1289	transmembrane transporter activity
AVL59_RS00815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVL59_RS00820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS00855	COG1396	sequence-specific DNA binding
AVL59_RS00860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL59_RS00890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVL59_RS00895	COG1957	nucleoside hydrolase
AVL59_RS00905	COG0366	Alpha amylase catalytic
AVL59_RS00925	COG0583	DNA-binding transcription factor activity
AVL59_RS00945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AVL59_RS00980	COG0745	RESPONSE REGULATOR receiver
AVL59_RS00985	COG5002	protein histidine kinase activity
AVL59_RS01080	COG1595	DNA-templated transcription, initiation
AVL59_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS01110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVL59_RS01135	COG4585	Histidine kinase
AVL59_RS01140	COG2197	response regulator
AVL59_RS01145	COG1136	(ABC) transporter
AVL59_RS01145	COG0577	efflux transmembrane transporter activity
AVL59_RS01175	COG2814	Major facilitator Superfamily
AVL59_RS01210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVL59_RS01235	COG2188	Transcriptional regulator
AVL59_RS01265	COG1595	DNA-templated transcription, initiation
AVL59_RS01270	COG1252	NADH dehydrogenase
AVL59_RS01275	COG3579	cysteine-type endopeptidase activity
AVL59_RS01330	COG2124	cytochrome p450
AVL59_RS01345	COG1473	amidohydrolase
AVL59_RS01360	COG0583	DNA-binding transcription factor activity
AVL59_RS01430	COG2192	nodulation
AVL59_RS01445	COG0644	oxidoreductase
AVL59_RS01450	COG2124	cytochrome p450
AVL59_RS01455	COG0842	Transport permease protein
AVL59_RS01475	COG2226	methyltransferase
AVL59_RS01485	COG0515	serine threonine protein kinase
AVL59_RS01485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS01515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVL59_RS01575	COG1278	Cold shock
AVL59_RS01645	COG0501	Belongs to the peptidase M48B family
AVL59_RS01650	COG0671	phosphoesterase, PA-phosphatase related
AVL59_RS01655	COG2205	protein histidine kinase activity
AVL59_RS01660	COG0745	RESPONSE REGULATOR receiver
AVL59_RS01690	COG0717	Belongs to the dCTP deaminase family
AVL59_RS01695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AVL59_RS01730	COG2181	nitrate reductase activity
AVL59_RS01730	COG0247	lactate metabolic process
AVL59_RS01735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVL59_RS01740	COG0443	Heat shock 70 kDa protein
AVL59_RS01745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVL59_RS01750	COG0484	heat shock protein binding
AVL59_RS01755	COG0789	Transcriptional regulator
AVL59_RS01765	COG4213	ABC transporter substrate-binding protein
AVL59_RS01815	COG0542	response to heat
AVL59_RS01845	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AVL59_RS01860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVL59_RS01885	COG3844	kynureninase activity
AVL59_RS01905	COG4585	Histidine kinase
AVL59_RS01910	COG2197	response regulator
AVL59_RS01915	COG4585	Histidine kinase
AVL59_RS01920	COG2197	response regulator
AVL59_RS01945	COG3559	Exporter of polyketide antibiotics
AVL59_RS01950	COG1131	(ABC) transporter
AVL59_RS01970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVL59_RS01990	COG0737	Belongs to the 5'-nucleotidase family
AVL59_RS02005	COG1802	Transcriptional regulator
AVL59_RS02010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVL59_RS02015	COG0693	protein deglycase activity
AVL59_RS02030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVL59_RS02040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVL59_RS02045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVL59_RS02090	COG1595	DNA-templated transcription, initiation
AVL59_RS02120	COG0701	Predicted permease
AVL59_RS02130	COG2815	serine threonine protein kinase
AVL59_RS02130	COG0515	serine threonine protein kinase
AVL59_RS02150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AVL59_RS02180	COG0531	amino acid
AVL59_RS02190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AVL59_RS02195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AVL59_RS02200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AVL59_RS02230	COG0640	Transcriptional regulator
AVL59_RS02235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVL59_RS02245	COG1316	TRANSCRIPTIONal
AVL59_RS02265	COG1408	metallophosphoesterase
AVL59_RS02285	COG0003	Pfam Anion-transporting ATPase
AVL59_RS02305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS02335	COG2267	carboxylic ester hydrolase activity
AVL59_RS02350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL59_RS02435	COG1205	dead DEAH box helicase
AVL59_RS02435	COG1111	helicase
AVL59_RS02440	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS02450	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AVL59_RS02470	COG1754	DNA topoisomerase type I activity
AVL59_RS02470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVL59_RS02475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVL59_RS02495	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVL59_RS02540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVL59_RS02545	COG0028	Belongs to the TPP enzyme family
AVL59_RS02545	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AVL59_RS02550	COG1454	alcohol dehydrogenase
AVL59_RS02555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVL59_RS02560	COG0436	Aminotransferase
AVL59_RS02600	COG1136	(ABC) transporter
AVL59_RS02600	COG0577	efflux transmembrane transporter activity
AVL59_RS02610	COG3629	intracellular signal transduction
AVL59_RS02610	COG3903	Transcriptional regulator
AVL59_RS02615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL59_RS02615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL59_RS02640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVL59_RS02645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVL59_RS02650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVL59_RS02655	COG0254	rRNA binding
AVL59_RS02665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVL59_RS02675	COG0640	Transcriptional regulator
AVL59_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS02705	COG2318	DinB family
AVL59_RS02725	COG0076	glutamate decarboxylase activity
AVL59_RS02735	COG0789	Transcriptional regulator
AVL59_RS02740	COG0393	Putative heavy-metal-binding
AVL59_RS02745	COG0586	Pfam SNARE associated Golgi protein
AVL59_RS02755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AVL59_RS02760	COG2027	D-alanyl-D-alanine carboxypeptidase
AVL59_RS02770	COG0037	tRNA processing
AVL59_RS02785	COG0302	gtp cyclohydrolase
AVL59_RS02800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVL59_RS02840	COG0649	NAD binding
AVL59_RS02855	COG2197	response regulator
AVL59_RS02880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVL59_RS02885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVL59_RS02895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVL59_RS02915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AVL59_RS02945	COG0739	heme binding
AVL59_RS02980	COG2205	protein histidine kinase activity
AVL59_RS02985	COG0745	RESPONSE REGULATOR receiver
AVL59_RS02995	COG1595	DNA-templated transcription, initiation
AVL59_RS03000	COG1194	a g-specific adenine glycosylase
AVL59_RS03015	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AVL59_RS03035	COG0248	Ppx GppA phosphatase
AVL59_RS03040	COG1082	Xylose isomerase domain protein TIM barrel
AVL59_RS03045	COG1309	transcriptional regulator
AVL59_RS03050	COG0129	dihydroxy-acid dehydratase activity
AVL59_RS03055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS03055	COG0515	serine threonine protein kinase
AVL59_RS03060	COG4991	sh3 domain protein
AVL59_RS03065	COG4991	sh3 domain protein
AVL59_RS03080	COG1129	ABC transporter
AVL59_RS03080	COG0842	Transport permease protein
AVL59_RS03090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVL59_RS03095	COG0180	Tryptophanyl-tRNA synthetase
AVL59_RS03125	COG2223	nitrite transmembrane transporter activity
AVL59_RS03130	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVL59_RS03175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AVL59_RS03180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVL59_RS03185	COG0181	hydroxymethylbilane synthase activity
AVL59_RS03190	COG1648	precorrin-2 dehydrogenase activity
AVL59_RS03190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVL59_RS03195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVL59_RS03200	COG0113	porphobilinogen synthase activity
AVL59_RS03205	COG3152	Membrane
AVL59_RS03210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS03245	COG0018	arginyl-trna synthetase
AVL59_RS03250	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AVL59_RS03270	COG1690	Belongs to the RtcB family
AVL59_RS03285	COG1742	UPF0060 membrane protein
AVL59_RS03295	COG1846	Transcriptional regulator
AVL59_RS03300	COG1733	regulation of RNA biosynthetic process
AVL59_RS03310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS03320	COG0745	RESPONSE REGULATOR receiver
AVL59_RS03330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVL59_RS03335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVL59_RS03335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVL59_RS03345	COG2362	D-Aminopeptidase
AVL59_RS03370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVL59_RS03375	COG0406	alpha-ribazole phosphatase activity
AVL59_RS03390	COG0785	Cytochrome C biogenesis protein
AVL59_RS03395	COG1333	cytochrome c biogenesis protein
AVL59_RS03400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVL59_RS03455	COG0697	spore germination
AVL59_RS03460	COG0583	DNA-binding transcription factor activity
AVL59_RS03470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVL59_RS03475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVL59_RS03480	COG0163	prenyltransferase activity
AVL59_RS03490	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL59_RS03505	COG1309	transcriptional regulator
AVL59_RS03550	COG3629	intracellular signal transduction
AVL59_RS03585	COG1278	Cold shock
AVL59_RS03590	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AVL59_RS03600	COG0515	serine threonine protein kinase
AVL59_RS03600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS03615	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL59_RS03625	COG2226	methyltransferase
AVL59_RS03645	COG0242	peptide deformylase activity
AVL59_RS03660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03670	COG0649	NAD binding
AVL59_RS03680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AVL59_RS03685	COG1034	ATP synthesis coupled electron transport
AVL59_RS03690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVL59_RS03695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03705	COG0713	ATP synthesis coupled electron transport
AVL59_RS03710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVL59_RS03720	COG1007	ATP synthesis coupled electron transport
AVL59_RS03730	COG0514	ATP-dependent DNA helicase (RecQ)
AVL59_RS03735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVL59_RS03740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVL59_RS03740	COG1116	anion transmembrane transporter activity
AVL59_RS03745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL59_RS03760	COG2188	Transcriptional regulator
AVL59_RS03790	COG0492	ferredoxin-NADP+ reductase activity
AVL59_RS03805	COG0561	phosphatase activity
AVL59_RS03815	COG0142	geranyltranstransferase activity
AVL59_RS03855	COG0702	epimerase
AVL59_RS03860	COG1733	regulation of RNA biosynthetic process
AVL59_RS03865	COG1013	pyruvate-flavodoxin oxidoreductase activity
AVL59_RS03870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AVL59_RS03870	COG0674	pyruvate-flavodoxin oxidoreductase activity
AVL59_RS03890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVL59_RS03910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03915	COG0839	Belongs to the complex I subunit 6 family
AVL59_RS03920	COG0713	ATP synthesis coupled electron transport
AVL59_RS03930	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVL59_RS03935	COG1007	ATP synthesis coupled electron transport
AVL59_RS03940	COG0501	Belongs to the peptidase M48B family
AVL59_RS03945	COG3304	Inner membrane component domain
AVL59_RS03955	COG2261	transglycosylase associated protein
AVL59_RS03960	COG1666	GTP binding
AVL59_RS03975	COG0702	epimerase
AVL59_RS03980	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS04000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVL59_RS04005	COG2030	dehydratase
AVL59_RS04025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVL59_RS04040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL59_RS04045	COG0436	Aminotransferase
AVL59_RS04060	COG0250	Participates in transcription elongation, termination and antitermination
AVL59_RS04075	COG0081	regulation of translation
AVL59_RS04085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVL59_RS04090	COG0222	ribosome binding
AVL59_RS04095	COG0085	RNA polymerase activity
AVL59_RS04100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVL59_RS04110	COG0515	serine threonine protein kinase
AVL59_RS04110	COG2815	serine threonine protein kinase
AVL59_RS04125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVL59_RS04130	COG0049	tRNA binding
AVL59_RS04135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVL59_RS04140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVL59_RS04160	COG2133	pyrroloquinoline quinone binding
AVL59_RS04205	COG0051	transcription antitermination factor activity, RNA binding
AVL59_RS04210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVL59_RS04215	COG0088	Forms part of the polypeptide exit tunnel
AVL59_RS04220	COG0089	rRNA binding
AVL59_RS04225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVL59_RS04230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVL59_RS04235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVL59_RS04240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVL59_RS04245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVL59_RS04250	COG0255	Belongs to the universal ribosomal protein uL29 family
AVL59_RS04255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVL59_RS04260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVL59_RS04265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVL59_RS04270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVL59_RS04275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVL59_RS04280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVL59_RS04285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVL59_RS04290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVL59_RS04295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVL59_RS04300	COG1841	ribosomal large subunit assembly
AVL59_RS04305	COG0200	Binds to the 23S rRNA
AVL59_RS04315	COG0563	adenylate kinase activity
AVL59_RS04325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVL59_RS04330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVL59_RS04335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVL59_RS04340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AVL59_RS04345	COG0202	RNA polymerase activity
AVL59_RS04350	COG0203	ribosomal protein L17
AVL59_RS04355	COG0101	tRNA pseudouridine synthase activity
AVL59_RS04365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVL59_RS04370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVL59_RS04375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVL59_RS04385	COG1072	(Pantothenic acid kinase))
AVL59_RS04395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVL59_RS04430	COG0736	holo-[acyl-carrier-protein] synthase activity
AVL59_RS04440	COG2197	response regulator
AVL59_RS04460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVL59_RS04465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS04470	COG0802	atpase or kinase
AVL59_RS04490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVL59_RS04510	COG1316	TRANSCRIPTIONal
AVL59_RS04525	COG4941	Belongs to the sigma-70 factor family
AVL59_RS04535	COG0726	polysaccharide deacetylase
AVL59_RS04540	COG0726	polysaccharide deacetylase
AVL59_RS04545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVL59_RS04550	COG0459	protein refolding
AVL59_RS04560	COG4221	oxidoreductase activity
AVL59_RS04570	COG0583	DNA-binding transcription factor activity
AVL59_RS04585	COG1595	DNA-templated transcription, initiation
AVL59_RS04595	COG0516	GMP reductase activity
AVL59_RS04605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AVL59_RS04620	COG2815	serine threonine protein kinase
AVL59_RS04620	COG0515	serine threonine protein kinase
AVL59_RS04625	COG0515	serine threonine protein kinase
AVL59_RS04630	COG0515	serine threonine protein kinase
AVL59_RS04635	COG0515	serine threonine protein kinase
AVL59_RS04640	COG2207	Transcriptional regulator
AVL59_RS04645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVL59_RS04655	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS04670	COG0519	Catalyzes the synthesis of GMP from XMP
AVL59_RS04670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVL59_RS04715	COG2197	response regulator
AVL59_RS04720	COG0791	NLP P60 protein
AVL59_RS04755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS04755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS04770	COG0714	Associated with various cellular activities
AVL59_RS04775	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AVL59_RS04780	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AVL59_RS04795	COG0045	succinate-CoA ligase (ADP-forming) activity
AVL59_RS04825	COG0138	bifunctional purine biosynthesis protein purh
AVL59_RS04835	COG2815	serine threonine protein kinase
AVL59_RS04835	COG0515	serine threonine protein kinase
AVL59_RS04850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVL59_RS04860	COG4585	Histidine kinase
AVL59_RS04865	COG2197	response regulator
AVL59_RS04875	COG0039	L-malate dehydrogenase activity
AVL59_RS04885	COG0477	Major facilitator Superfamily
AVL59_RS04905	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS04915	COG0517	IMP dehydrogenase activity
AVL59_RS04915	COG4175	Glycine betaine
AVL59_RS04920	COG4176	ABC-type proline glycine betaine transport system permease component
AVL59_RS04935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS04940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS04945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS04965	COG0754	glutathionylspermidine amidase activity
AVL59_RS04970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL59_RS04975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVL59_RS04980	COG0180	Tryptophanyl-tRNA synthetase
AVL59_RS04995	COG1295	ribonuclease BN
AVL59_RS05020	COG1309	transcriptional regulator
AVL59_RS05050	COG1053	succinate dehydrogenase
AVL59_RS05060	COG2009	succinate dehydrogenase
AVL59_RS05070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AVL59_RS05100	COG1595	DNA-templated transcription, initiation
AVL59_RS05115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS05115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS05135	COG1216	Glycosyl transferase, family 2
AVL59_RS05150	COG2089	acid synthase
AVL59_RS05180	COG1473	amidohydrolase
AVL59_RS05180	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AVL59_RS05185	COG1744	ABC transporter substrate-binding protein PnrA-like
AVL59_RS05190	COG1744	ABC transporter substrate-binding protein PnrA-like
AVL59_RS05195	COG3845	ABC transporter
AVL59_RS05205	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVL59_RS05235	COG2814	Major facilitator Superfamily
AVL59_RS05240	COG0583	DNA-binding transcription factor activity
AVL59_RS05250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL59_RS05275	COG2205	protein histidine kinase activity
AVL59_RS05280	COG0745	RESPONSE REGULATOR receiver
AVL59_RS05285	COG1595	DNA-templated transcription, initiation
AVL59_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS05320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVL59_RS05345	COG4770	biotin carboxylase activity
AVL59_RS05355	COG0424	maF-like protein
AVL59_RS05365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL59_RS05375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AVL59_RS05385	COG1024	Enoyl-CoA hydratase
AVL59_RS05395	COG2986	histidine ammonia-lyase
AVL59_RS05420	COG1136	(ABC) transporter
AVL59_RS05425	COG1404	Belongs to the peptidase S8 family
AVL59_RS05445	COG1064	alcohol dehydrogenase
AVL59_RS05460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL59_RS05470	COG0501	Belongs to the peptidase M48B family
AVL59_RS05490	COG1595	DNA-templated transcription, initiation
AVL59_RS05495	COG2255	four-way junction helicase activity
AVL59_RS05500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVL59_RS05515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVL59_RS05525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVL59_RS05550	COG1331	Highly conserved protein containing a thioredoxin domain
AVL59_RS05580	COG1309	transcriptional regulator
AVL59_RS05585	COG0477	Major facilitator Superfamily
AVL59_RS05595	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AVL59_RS05605	COG0436	Aminotransferase
AVL59_RS05625	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AVL59_RS05640	COG1414	Transcriptional regulator
AVL59_RS05645	COG0251	oxidation-reduction process
AVL59_RS05650	COG2610	gluconate transmembrane transporter activity
AVL59_RS05685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVL59_RS05730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL59_RS05735	COG0222	ribosome binding
AVL59_RS05775	COG2894	cell division
AVL59_RS05805	COG3850	Histidine kinase
AVL59_RS05810	COG2197	response regulator
AVL59_RS05830	COG2885	chlorophyll binding
AVL59_RS05925	COG2318	DinB family
AVL59_RS05930	COG2226	methyltransferase
AVL59_RS05935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVL59_RS05940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AVL59_RS05955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS05960	COG0450	alkyl hydroperoxide reductase
AVL59_RS05990	COG1136	(ABC) transporter
AVL59_RS06010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL59_RS06010	COG4499	WXG100 protein secretion system (Wss), protein YukC
AVL59_RS06025	COG0114	fumarate hydratase activity
AVL59_RS06065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AVL59_RS06065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AVL59_RS06090	COG0778	Nitroreductase
AVL59_RS06095	COG1722	exodeoxyribonuclease VII activity
AVL59_RS06100	COG1570	exodeoxyribonuclease VII activity
AVL59_RS06105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVL59_RS06120	COG0012	GTP binding
AVL59_RS06125	COG2161	toxin-antitoxin pair type II binding
AVL59_RS06130	COG4115	mRNA cleavage
AVL59_RS06210	COG1053	succinate dehydrogenase
AVL59_RS06230	COG1217	gtp-binding protein TYPA
AVL59_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVL59_RS06240	COG4166	transmembrane transport
AVL59_RS06245	COG0601	transmembrane transport
AVL59_RS06250	COG0444	Belongs to the ABC transporter superfamily
AVL59_RS06255	COG4608	Belongs to the ABC transporter superfamily
AVL59_RS06260	COG2226	methyltransferase
AVL59_RS06290	COG4608	Belongs to the ABC transporter superfamily
AVL59_RS06295	COG0444	Belongs to the ABC transporter superfamily
AVL59_RS06300	COG0601	transmembrane transport
AVL59_RS06310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVL59_RS06320	COG0601	transmembrane transport
AVL59_RS06325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVL59_RS06330	COG0444	Belongs to the ABC transporter superfamily
AVL59_RS06335	COG4608	Belongs to the ABC transporter superfamily
AVL59_RS06350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVL59_RS06365	COG1131	(ABC) transporter
AVL59_RS06375	COG4585	Histidine kinase
AVL59_RS06380	COG2197	response regulator
AVL59_RS06415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVL59_RS06420	COG1611	Belongs to the LOG family
AVL59_RS06425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVL59_RS06435	COG0519	Catalyzes the synthesis of GMP from XMP
AVL59_RS06440	COG1024	Enoyl-CoA hydratase
AVL59_RS06455	COG1595	DNA-templated transcription, initiation
AVL59_RS06465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL59_RS06470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL59_RS06515	COG0598	Magnesium transport protein CorA
AVL59_RS06535	COG2095	MarC family integral membrane protein
AVL59_RS06540	COG1432	Conserved Protein
AVL59_RS06550	COG0513	Belongs to the DEAD box helicase family
AVL59_RS06595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVL59_RS06600	COG0601	transmembrane transport
AVL59_RS06605	COG4172	Belongs to the ABC transporter superfamily
AVL59_RS06660	COG0210	DNA helicase
AVL59_RS06670	COG2816	NAD+ diphosphatase activity
AVL59_RS06700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL59_RS06750	COG3480	Lon protease (S16) C-terminal proteolytic domain
AVL59_RS06760	COG1615	UPF0182 protein
AVL59_RS06795	COG0483	inositol monophosphate 1-phosphatase activity
AVL59_RS06805	COG2076	Multidrug Resistance protein
AVL59_RS06810	COG1162	GTPase activity
AVL59_RS06815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVL59_RS06825	COG2135	peptidase activity
AVL59_RS06835	COG1595	DNA-templated transcription, initiation
AVL59_RS06840	COG5662	AntiSigma factor
AVL59_RS06845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AVL59_RS06845	COG2199	diguanylate cyclase activity
AVL59_RS06860	COG0242	peptide deformylase activity
AVL59_RS06870	COG2124	cytochrome p450
AVL59_RS06895	COG2188	Transcriptional regulator
AVL59_RS06900	COG0363	glucosamine-6-phosphate deaminase activity
AVL59_RS06920	COG1597	lipid kinase activity
AVL59_RS06950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AVL59_RS06960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL59_RS06965	COG0142	geranyltranstransferase activity
AVL59_RS07020	COG2326	polyphosphate kinase activity
AVL59_RS07060	COG1126	abc transporter atp-binding protein
AVL59_RS07065	COG0765	amino acid transport
AVL59_RS07075	COG0281	malic enzyme
AVL59_RS07080	COG0604	alcohol dehydrogenase
AVL59_RS07110	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL59_RS07110	COG0567	Dehydrogenase, E1 component
AVL59_RS07115	COG2205	protein histidine kinase activity
AVL59_RS07120	COG0745	RESPONSE REGULATOR receiver
AVL59_RS07140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVL59_RS07195	COG3883	PFAM NLP P60 protein
AVL59_RS07195	COG0791	NLP P60 protein
AVL59_RS07225	COG0768	penicillin binding
AVL59_RS07230	COG0772	Belongs to the SEDS family
AVL59_RS07235	COG2205	protein histidine kinase activity
AVL59_RS07255	COG1793	dna ligase
AVL59_RS07255	COG3285	dna ligase
AVL59_RS07260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AVL59_RS07275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL59_RS07315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL59_RS07320	COG0805	protein transport
AVL59_RS07325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL59_RS07360	COG2755	lipolytic protein G-D-S-L family
AVL59_RS07370	COG2318	DinB family
AVL59_RS07390	COG0745	RESPONSE REGULATOR receiver
AVL59_RS07395	COG0018	arginyl-trna synthetase
AVL59_RS07400	COG0019	diaminopimelate decarboxylase activity
AVL59_RS07405	COG0460	homoserine dehydrogenase
AVL59_RS07410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AVL59_RS07415	COG0083	homoserine kinase activity
AVL59_RS07435	COG0254	rRNA binding
AVL59_RS07440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVL59_RS07445	COG2890	protein-(glutamine-N5) methyltransferase activity
AVL59_RS07455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVL59_RS07460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVL59_RS07465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVL59_RS07480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVL59_RS07485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVL59_RS07490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVL59_RS07495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVL59_RS07500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVL59_RS07505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVL59_RS07510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVL59_RS07525	COG2197	response regulator
AVL59_RS07530	COG4585	Histidine kinase
AVL59_RS07560	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL59_RS07575	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AVL59_RS07610	COG1131	(ABC) transporter
AVL59_RS07630	COG0183	Belongs to the thiolase family
AVL59_RS07685	COG1309	transcriptional regulator
AVL59_RS07710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS07710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS07750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVL59_RS07755	COG0280	phosphate acetyltransferase
AVL59_RS07755	COG0857	belongs to the CobB CobQ family
AVL59_RS07760	COG0205	6-phosphofructokinase activity
AVL59_RS07770	COG0395	ABC-type sugar transport system, permease component
AVL59_RS07775	COG1175	transmembrane transport
AVL59_RS07785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVL59_RS07790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL59_RS07810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL59_RS07830	COG3458	cephalosporin-C deacetylase activity
AVL59_RS07845	COG0367	asparagine synthase
AVL59_RS07885	COG4565	transcriptional regulatory protein
AVL59_RS07890	COG3290	protein histidine kinase activity
AVL59_RS07895	COG1301	dicarboxylic acid transport
AVL59_RS07905	COG0477	Major facilitator Superfamily
AVL59_RS08060	COG1674	ftsk spoiiie
AVL59_RS08070	COG0667	Aldo Keto reductase
AVL59_RS08080	COG1522	sequence-specific DNA binding
AVL59_RS08085	COG0789	Transcriptional regulator
AVL59_RS08090	COG3118	belongs to the thioredoxin family
AVL59_RS08100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVL59_RS08105	COG3281	Trehalose synthase
AVL59_RS08115	COG0366	Alpha amylase catalytic
AVL59_RS08120	COG0058	SHG alpha-glucan phosphorylase activity
AVL59_RS08145	COG1132	(ABC) transporter
AVL59_RS08150	COG1132	(ABC) transporter
AVL59_RS08155	COG1132	(ABC) transporter
AVL59_RS08160	COG1132	(ABC) transporter
AVL59_RS08175	COG0463	Glycosyl transferase, family 2
AVL59_RS08200	COG1376	ErfK ybiS ycfS ynhG family protein
AVL59_RS08240	COG1063	alcohol dehydrogenase
AVL59_RS08245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL59_RS08270	COG3903	Transcriptional regulator
AVL59_RS08270	COG3629	intracellular signal transduction
AVL59_RS08285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS08300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS08305	COG2226	methyltransferase
AVL59_RS08305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS08305	COG3433	isochorismatase activity
AVL59_RS08325	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS08340	COG1228	amidohydrolase
AVL59_RS08350	COG1760	l-serine dehydratase
AVL59_RS08355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVL59_RS08360	COG0509	glycine decarboxylation via glycine cleavage system
AVL59_RS08365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVL59_RS08385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVL59_RS08390	COG0747	negative chemotaxis
AVL59_RS08400	COG0444	Belongs to the ABC transporter superfamily
AVL59_RS08405	COG4608	Belongs to the ABC transporter superfamily
AVL59_RS08415	COG2860	membrane
AVL59_RS08435	COG2378	regulation of single-species biofilm formation
AVL59_RS08460	COG0482	sulfurtransferase activity
AVL59_RS08475	COG1611	Belongs to the LOG family
AVL59_RS08480	COG4221	oxidoreductase activity
AVL59_RS08490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVL59_RS08515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVL59_RS08520	COG0154	amidase activity
AVL59_RS08530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVL59_RS08545	COG2409	Drug exporters of the RND superfamily
AVL59_RS08550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS08565	COG1672	PFAM Archaeal ATPase
AVL59_RS08565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AVL59_RS08580	COG0667	Aldo Keto reductase
AVL59_RS08590	COG5001	Diguanylate cyclase
AVL59_RS08600	COG0440	acetolactate synthase activity
AVL59_RS08605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVL59_RS08610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL59_RS08615	COG0477	Major facilitator Superfamily
AVL59_RS08630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS08635	COG2508	Transcriptional regulator
AVL59_RS08640	COG0506	proline dehydrogenase activity
AVL59_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS08665	COG0473	3-isopropylmalate dehydrogenase activity
AVL59_RS08670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVL59_RS08680	COG0832	Belongs to the urease beta subunit family
AVL59_RS08680	COG0831	urea catabolic process
AVL59_RS08685	COG0804	urea catabolic process
AVL59_RS08690	COG2957	Belongs to the agmatine deiminase family
AVL59_RS08700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVL59_RS08720	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL59_RS08745	COG2353	YceI-like domain
AVL59_RS08750	COG5492	domain, Protein
AVL59_RS08755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL59_RS08775	COG2018	Roadblock/LC7 domain
AVL59_RS08795	COG2018	Roadblock/LC7 domain
AVL59_RS08800	COG5002	protein histidine kinase activity
AVL59_RS08810	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVL59_RS08815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVL59_RS08825	COG0546	phosphoglycolate phosphatase activity
AVL59_RS08865	COG1414	Transcriptional regulator
AVL59_RS08870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVL59_RS08875	COG0066	3-isopropylmalate dehydratase activity
AVL59_RS08885	COG0776	regulation of translation
AVL59_RS08895	COG1920	GTP binding
AVL59_RS08905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVL59_RS08910	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVL59_RS08930	COG0351	phosphomethylpyrimidine kinase
AVL59_RS08935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVL59_RS08940	COG1461	Dihydroxyacetone kinase
AVL59_RS08950	COG0326	Molecular chaperone. Has ATPase activity
AVL59_RS08960	COG0742	ribosomal rna small subunit methyltransferase
AVL59_RS08965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVL59_RS08980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVL59_RS08985	COG0571	ribonuclease III activity
AVL59_RS08990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVL59_RS08995	COG1733	regulation of RNA biosynthetic process
AVL59_RS09000	COG0655	NAD(P)H dehydrogenase (quinone) activity
AVL59_RS09005	COG2340	Cysteine-rich secretory protein family
AVL59_RS09010	COG1254	Belongs to the acylphosphatase family
AVL59_RS09025	COG0477	Major facilitator Superfamily
AVL59_RS09075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AVL59_RS09085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVL59_RS09100	COG0228	four-way junction DNA binding
AVL59_RS09105	COG1837	Belongs to the UPF0109 family
AVL59_RS09110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVL59_RS09115	COG0336	Belongs to the RNA methyltransferase TrmD family
AVL59_RS09120	COG0335	large ribosomal subunit rRNA binding
AVL59_RS09125	COG0681	Belongs to the peptidase S26 family
AVL59_RS09130	COG0681	Belongs to the peptidase S26 family
AVL59_RS09150	COG0792	nuclease activity
AVL59_RS09165	COG1191	sigma factor activity
AVL59_RS09175	COG0739	heme binding
AVL59_RS09175	COG1196	nuclear chromosome segregation
AVL59_RS09175	COG0741	lytic transglycosylase activity
AVL59_RS09180	COG0052	Belongs to the universal ribosomal protein uS2 family
AVL59_RS09190	COG0528	UMP kinase activity
AVL59_RS09195	COG0233	cytoplasmic translational termination
AVL59_RS09200	COG0575	Belongs to the CDS family
AVL59_RS09220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVL59_RS09230	COG4208	sulfate ABC transporter
AVL59_RS09235	COG3842	ATPase activity
AVL59_RS09255	COG1136	(ABC) transporter
AVL59_RS09260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVL59_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS09295	COG3903	Transcriptional regulator
AVL59_RS09295	COG3629	intracellular signal transduction
AVL59_RS09310	COG0657	acetylesterase activity
AVL59_RS09410	COG0584	glycerophosphoryl diester phosphodiesterase
AVL59_RS09415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL59_RS09440	COG3842	ATPase activity
AVL59_RS09445	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVL59_RS09450	COG1177	transmembrane transport
AVL59_RS09455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL59_RS09490	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS09520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVL59_RS09525	COG0750	zinc metalloprotease
AVL59_RS09530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVL59_RS09545	COG0640	Transcriptional regulator
AVL59_RS09555	COG0442	prolyl-tRNA aminoacylation
AVL59_RS09575	COG0779	Required for maturation of 30S ribosomal subunits
AVL59_RS09590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVL59_RS09600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVL59_RS09605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVL59_RS09620	COG0455	bacterial-type flagellum organization
AVL59_RS09635	COG3266	domain, Protein
AVL59_RS09640	COG1404	Belongs to the peptidase S8 family
AVL59_RS09695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS09695	COG0515	serine threonine protein kinase
AVL59_RS09705	COG1674	ftsk spoiiie
AVL59_RS09720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVL59_RS09725	COG1185	polyribonucleotide nucleotidyltransferase activity
AVL59_RS09730	COG0612	Peptidase, M16
AVL59_RS09735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVL59_RS09755	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AVL59_RS09760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL59_RS09765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AVL59_RS09795	COG2208	phosphoserine phosphatase activity
AVL59_RS09795	COG2770	Histidine kinase
AVL59_RS09800	COG2205	protein histidine kinase activity
AVL59_RS09800	COG0784	Response regulator, receiver
AVL59_RS09810	COG1674	ftsk spoiiie
AVL59_RS09820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVL59_RS09830	COG1058	Belongs to the CinA family
AVL59_RS09830	COG1546	Belongs to the CinA family
AVL59_RS09835	COG1396	sequence-specific DNA binding
AVL59_RS09840	COG0783	Belongs to the Dps family
AVL59_RS09850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVL59_RS09855	COG1201	RNA secondary structure unwinding
AVL59_RS09870	COG0628	permease
AVL59_RS09880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS09885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVL59_RS09910	COG0765	amino acid transport
AVL59_RS09915	COG0765	amino acid transport
AVL59_RS09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL59_RS09925	COG1126	abc transporter atp-binding protein
AVL59_RS09930	COG0745	RESPONSE REGULATOR receiver
AVL59_RS09935	COG2205	protein histidine kinase activity
AVL59_RS09940	COG2358	TRAP transporter, solute receptor (TAXI family
AVL59_RS09975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVL59_RS09995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVL59_RS10005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVL59_RS10010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVL59_RS10020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVL59_RS10035	COG1278	Cold shock
AVL59_RS10040	COG1278	Cold shock
AVL59_RS10055	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AVL59_RS10060	COG0326	Molecular chaperone. Has ATPase activity
AVL59_RS10120	COG3321	synthase
AVL59_RS10120	COG0604	alcohol dehydrogenase
AVL59_RS10135	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL59_RS10145	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS10155	COG3321	synthase
AVL59_RS10155	COG0604	alcohol dehydrogenase
AVL59_RS10160	COG3321	synthase
AVL59_RS10160	COG0604	alcohol dehydrogenase
AVL59_RS10175	COG2197	response regulator
AVL59_RS10205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVL59_RS10210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVL59_RS10215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVL59_RS10230	COG0588	phosphoglycerate mutase activity
AVL59_RS10250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVL59_RS10285	COG1131	(ABC) transporter
AVL59_RS10290	COG2186	Transcriptional regulator
AVL59_RS10295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVL59_RS10310	COG0187	DNA topoisomerase II activity
AVL59_RS10325	COG2197	response regulator
AVL59_RS10335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL59_RS10350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL59_RS10360	COG4565	transcriptional regulatory protein
AVL59_RS10365	COG3290	protein histidine kinase activity
AVL59_RS10380	COG0372	Belongs to the citrate synthase family
AVL59_RS10390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVL59_RS10395	COG0612	Peptidase, M16
AVL59_RS10410	COG1802	Transcriptional regulator
AVL59_RS10415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVL59_RS10440	COG1435	thymidine kinase activity
AVL59_RS10480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVL59_RS10490	COG0745	RESPONSE REGULATOR receiver
AVL59_RS10495	COG2205	protein histidine kinase activity
AVL59_RS10520	COG0756	dUTP diphosphatase activity
AVL59_RS10530	COG1136	(ABC) transporter
AVL59_RS10560	COG0569	domain protein
AVL59_RS10565	COG0531	amino acid
AVL59_RS10570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVL59_RS10585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL59_RS10595	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVL59_RS10615	COG1063	alcohol dehydrogenase
AVL59_RS10620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVL59_RS10620	COG2124	cytochrome p450
AVL59_RS10660	COG2124	cytochrome p450
AVL59_RS10675	COG0628	permease
AVL59_RS10705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS10730	COG1595	DNA-templated transcription, initiation
AVL59_RS10745	COG0745	RESPONSE REGULATOR receiver
AVL59_RS10750	COG2205	protein histidine kinase activity
AVL59_RS10785	COG0300	oxidoreductase activity
AVL59_RS10790	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVL59_RS10815	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AVL59_RS10815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS10820	COG0644	oxidoreductase
AVL59_RS10835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS10855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AVL59_RS10875	COG0384	phenazine biosynthesis protein PhzF
AVL59_RS10895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS10915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS10935	COG0604	alcohol dehydrogenase
AVL59_RS10935	COG3321	synthase
AVL59_RS10980	COG1834	amidinotransferase
AVL59_RS11010	COG2409	Drug exporters of the RND superfamily
AVL59_RS11040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AVL59_RS11050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AVL59_RS11115	COG1799	cell septum assembly
AVL59_RS11145	COG3196	Protein conserved in bacteria
AVL59_RS11165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVL59_RS11195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVL59_RS11200	COG0531	amino acid
AVL59_RS11210	COG1024	Enoyl-CoA hydratase
AVL59_RS11235	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS11260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL59_RS11265	COG3629	intracellular signal transduction
AVL59_RS11280	COG2814	Major facilitator Superfamily
AVL59_RS11290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVL59_RS11295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVL59_RS11305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS11310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS11315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS11340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL59_RS11350	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS11380	COG0477	Major facilitator Superfamily
AVL59_RS11415	COG2188	Transcriptional regulator
AVL59_RS11420	COG2182	Extracellular solute-binding protein
AVL59_RS11425	COG1175	transmembrane transport
AVL59_RS11430	COG0395	ABC-type sugar transport system, permease component
AVL59_RS11435	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL59_RS11450	COG0019	diaminopimelate decarboxylase activity
AVL59_RS11465	COG0702	epimerase
AVL59_RS11485	COG2807	transmembrane transport
AVL59_RS11490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVL59_RS11490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS11495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVL59_RS11500	COG0730	response to heat
AVL59_RS11505	COG1937	Protein conserved in bacteria
AVL59_RS11535	COG1132	(ABC) transporter
AVL59_RS11540	COG1132	(ABC) transporter
AVL59_RS11560	COG3903	Transcriptional regulator
AVL59_RS11560	COG3629	intracellular signal transduction
AVL59_RS11570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVL59_RS11580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AVL59_RS11585	COG2205	protein histidine kinase activity
AVL59_RS11590	COG3290	protein histidine kinase activity
AVL59_RS11605	COG1653	transport
AVL59_RS11610	COG1175	transmembrane transport
AVL59_RS11615	COG0395	ABC-type sugar transport system, permease component
AVL59_RS11625	COG1940	carbohydrate kinase activity
AVL59_RS11630	COG4213	ABC transporter substrate-binding protein
AVL59_RS11640	COG4214	carbohydrate transport
AVL59_RS11645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVL59_RS11650	COG0531	amino acid
AVL59_RS11675	COG1024	Enoyl-CoA hydratase
AVL59_RS11675	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL59_RS11680	COG0183	Belongs to the thiolase family
AVL59_RS11685	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AVL59_RS11700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVL59_RS11715	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL59_RS11725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AVL59_RS11730	COG3253	May function as heme-dependent peroxidase
AVL59_RS11750	COG3220	belongs to the UPF0276 family
AVL59_RS11770	COG1116	anion transmembrane transporter activity
AVL59_RS11795	COG1881	PFAM PEBP family protein
AVL59_RS11800	COG0330	HflC and HflK could
AVL59_RS11805	COG0659	secondary active sulfate transmembrane transporter activity
AVL59_RS11830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVL59_RS11835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL59_RS11850	COG1174	glycine betaine transport
AVL59_RS11870	COG2018	Roadblock/LC7 domain
AVL59_RS11875	COG5002	protein histidine kinase activity
AVL59_RS11895	COG0477	Major facilitator Superfamily
AVL59_RS11935	COG1309	transcriptional regulator
AVL59_RS11975	COG3173	Aminoglycoside phosphotransferase
AVL59_RS11985	COG1716	ATPase activity
AVL59_RS12000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL59_RS12005	COG0583	DNA-binding transcription factor activity
AVL59_RS12055	COG0583	DNA-binding transcription factor activity
AVL59_RS12065	COG1175	transmembrane transport
AVL59_RS12095	COG0583	DNA-binding transcription factor activity
AVL59_RS12130	COG2409	Drug exporters of the RND superfamily
AVL59_RS12140	COG1595	DNA-templated transcription, initiation
AVL59_RS12145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AVL59_RS12165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL59_RS12170	COG1116	anion transmembrane transporter activity
AVL59_RS12170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVL59_RS12190	COG0529	Catalyzes the synthesis of activated sulfate
AVL59_RS12195	COG0175	sulfate reduction
AVL59_RS12210	COG0456	acetyltransferase
AVL59_RS12225	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS12235	COG0702	epimerase
AVL59_RS12240	COG1917	Cupin 2, conserved barrel domain protein
AVL59_RS12240	COG4977	sequence-specific DNA binding
AVL59_RS12270	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AVL59_RS12295	COG1609	Transcriptional regulator
AVL59_RS12300	COG2040	homocysteine
AVL59_RS12315	COG0667	Aldo Keto reductase
AVL59_RS12365	COG0277	FAD linked oxidase domain protein
AVL59_RS12385	COG4977	sequence-specific DNA binding
AVL59_RS12455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AVL59_RS12465	COG0483	inositol monophosphate 1-phosphatase activity
AVL59_RS12475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AVL59_RS12495	COG0473	3-isopropylmalate dehydrogenase activity
AVL59_RS12515	COG0166	Belongs to the GPI family
AVL59_RS12520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVL59_RS12535	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVL59_RS12545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVL59_RS12550	COG1063	alcohol dehydrogenase
AVL59_RS12555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL59_RS12560	COG0667	Aldo Keto reductase
AVL59_RS12580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS12605	COG1162	GTPase activity
AVL59_RS12620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVL59_RS12645	COG0028	Belongs to the TPP enzyme family
AVL59_RS12660	COG1802	Transcriptional regulator
AVL59_RS12685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL59_RS12690	COG2252	PERMEase
AVL59_RS12770	COG5634	Uncharacterized conserved protein (DUF2278)
AVL59_RS12805	COG1653	transport
AVL59_RS12815	COG2326	polyphosphate kinase activity
AVL59_RS12820	COG0477	Major facilitator Superfamily
AVL59_RS12830	COG0598	Magnesium transport protein CorA
AVL59_RS12840	COG0583	DNA-binding transcription factor activity
AVL59_RS12860	COG2197	response regulator
AVL59_RS12865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL59_RS12870	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS12880	COG3960	tartronate-semialdehyde synthase activity
AVL59_RS12890	COG0753	catalase activity
AVL59_RS12895	COG2084	Dehydrogenase
AVL59_RS12900	COG3622	Belongs to the hyi family
AVL59_RS12950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVL59_RS12985	COG2351	hydroxyisourate hydrolase activity
AVL59_RS13000	COG2233	PERMEase
AVL59_RS13005	COG3548	integral membrane protein
AVL59_RS13020	COG1733	regulation of RNA biosynthetic process
AVL59_RS13035	COG0406	alpha-ribazole phosphatase activity
AVL59_RS13060	COG0436	Aminotransferase
AVL59_RS13065	COG1733	regulation of RNA biosynthetic process
AVL59_RS13080	COG4264	IucA IucC family
AVL59_RS13090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS13120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AVL59_RS13135	COG1414	Transcriptional regulator
AVL59_RS13140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AVL59_RS13145	COG4266	Belongs to the allantoicase family
AVL59_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS13180	COG2197	response regulator
AVL59_RS13185	COG0673	inositol 2-dehydrogenase activity
AVL59_RS13190	COG2188	Transcriptional regulator
AVL59_RS13210	COG1940	carbohydrate kinase activity
AVL59_RS13220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVL59_RS13255	COG1408	metallophosphoesterase
AVL59_RS13260	COG1063	alcohol dehydrogenase
AVL59_RS13265	COG0667	Aldo Keto reductase
AVL59_RS13300	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS13315	COG0702	epimerase
AVL59_RS13320	COG3631	Ketosteroid isomerase-related protein
AVL59_RS13345	COG0330	HflC and HflK could
AVL59_RS13380	COG1764	response to oxidative stress
AVL59_RS13410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS13415	COG0174	glutamine synthetase
AVL59_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS13440	COG4689	acetoacetate decarboxylase
AVL59_RS13450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AVL59_RS13455	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS13465	COG3885	ferrous iron binding
AVL59_RS13465	COG2078	PFAM AMMECR1 domain protein
AVL59_RS13480	COG0519	Catalyzes the synthesis of GMP from XMP
AVL59_RS13525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS13530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AVL59_RS13545	COG1126	abc transporter atp-binding protein
AVL59_RS13555	COG0765	amino acid transport
AVL59_RS13560	COG0765	amino acid transport
AVL59_RS13575	COG0405	Gamma-glutamyltransferase
AVL59_RS13580	COG0542	response to heat
AVL59_RS13605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL59_RS13620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AVL59_RS13640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVL59_RS13685	COG0598	Magnesium transport protein CorA
AVL59_RS13695	COG0483	inositol monophosphate 1-phosphatase activity
AVL59_RS13705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AVL59_RS13710	COG2824	Alkylphosphonate utilization operon protein PhnA
AVL59_RS13720	COG0659	secondary active sulfate transmembrane transporter activity
AVL59_RS13765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVL59_RS13840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVL59_RS13855	COG1929	Belongs to the glycerate kinase type-1 family
AVL59_RS13865	COG0688	phosphatidylethanolamine metabolic process
AVL59_RS13870	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS13885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS13885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AVL59_RS13900	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL59_RS13910	COG0456	acetyltransferase
AVL59_RS13920	COG0596	Alpha beta hydrolase
AVL59_RS13940	COG2208	phosphoserine phosphatase activity
AVL59_RS13940	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS13940	COG2172	sigma factor antagonist activity
AVL59_RS13945	COG4106	trans-aconitate 2-methyltransferase activity
AVL59_RS13950	COG2362	D-Aminopeptidase
AVL59_RS13955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVL59_RS13965	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVL59_RS14005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVL59_RS14015	COG2226	methyltransferase
AVL59_RS14020	COG1597	lipid kinase activity
AVL59_RS14025	COG0406	alpha-ribazole phosphatase activity
AVL59_RS14030	COG0488	(ABC) transporter
AVL59_RS14065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AVL59_RS14085	COG0443	Heat shock 70 kDa protein
AVL59_RS14100	COG1140	nitrate reductase beta subunit
AVL59_RS14130	COG2154	pterin-4-alpha-carbinolamine dehydratase
AVL59_RS14135	COG2226	methyltransferase
AVL59_RS14145	COG2239	Acts as a magnesium transporter
AVL59_RS14160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVL59_RS14175	COG1063	alcohol dehydrogenase
AVL59_RS14195	COG0516	GMP reductase activity
AVL59_RS14195	COG0517	IMP dehydrogenase activity
AVL59_RS14200	COG0516	GMP reductase activity
AVL59_RS14200	COG0517	IMP dehydrogenase activity
AVL59_RS14210	COG1042	CoA-binding domain protein
AVL59_RS14210	COG0045	succinate-CoA ligase (ADP-forming) activity
AVL59_RS14210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS14220	COG4221	oxidoreductase activity
AVL59_RS14235	COG0656	L-ascorbic acid biosynthetic process
AVL59_RS14255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AVL59_RS14270	COG3469	chitinase activity
AVL59_RS14275	COG3250	beta-galactosidase activity
AVL59_RS14280	COG1022	Amp-dependent synthetase and ligase
AVL59_RS14285	COG0477	Major facilitator Superfamily
AVL59_RS14320	COG1335	isochorismatase
AVL59_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS14330	COG0583	DNA-binding transcription factor activity
AVL59_RS14335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AVL59_RS14345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS14360	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS14395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVL59_RS14410	COG1940	carbohydrate kinase activity
AVL59_RS14415	COG2182	Extracellular solute-binding protein
AVL59_RS14420	COG1175	transmembrane transport
AVL59_RS14425	COG0395	ABC-type sugar transport system, permease component
AVL59_RS14430	COG2723	6-phospho-beta-galactosidase activity
AVL59_RS14460	COG0297	glycogen (starch) synthase activity
AVL59_RS14475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVL59_RS14480	COG2423	ornithine cyclodeaminase activity
AVL59_RS14500	COG0477	Major facilitator Superfamily
AVL59_RS14510	COG0009	L-threonylcarbamoyladenylate synthase
AVL59_RS14530	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS14560	COG3467	pyridoxamine 5'-phosphate
AVL59_RS14580	COG0588	phosphoglycerate mutase activity
AVL59_RS14585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AVL59_RS14590	COG0166	Belongs to the GPI family
AVL59_RS14605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVL59_RS14625	COG3739	integral membrane protein
AVL59_RS14640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVL59_RS14650	COG1486	melibiose metabolic process
AVL59_RS14660	COG3469	chitinase activity
AVL59_RS14670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVL59_RS14710	COG1175	transmembrane transport
AVL59_RS14715	COG0395	ABC-type sugar transport system, permease component
AVL59_RS14720	COG0366	Alpha amylase catalytic
AVL59_RS14750	COG3511	phospholipase C
AVL59_RS14795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVL59_RS14800	COG0477	Major facilitator Superfamily
AVL59_RS14810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS14815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVL59_RS14820	COG3485	protocatechuate 3,4-dioxygenase
AVL59_RS14825	COG3485	protocatechuate 3,4-dioxygenase
AVL59_RS14855	COG1793	dna ligase
AVL59_RS14930	COG1834	amidinotransferase
AVL59_RS14935	COG0488	(ABC) transporter
AVL59_RS14965	COG1515	deoxyribonuclease V activity
AVL59_RS14975	COG3268	Saccharopine dehydrogenase
AVL59_RS14980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVL59_RS14985	COG0183	Belongs to the thiolase family
AVL59_RS14990	COG1024	Enoyl-CoA hydratase
AVL59_RS14990	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVL59_RS15000	COG1113	amino acid transport
AVL59_RS15010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL59_RS15020	COG2936	dipeptidyl-peptidase activity
AVL59_RS15035	COG0488	(ABC) transporter
AVL59_RS15055	COG2183	response to ionizing radiation
AVL59_RS15060	COG4977	sequence-specific DNA binding
AVL59_RS15070	COG1024	Enoyl-CoA hydratase
AVL59_RS15080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AVL59_RS15125	COG1134	teichoic acid transport
AVL59_RS15130	COG1562	ergosterol biosynthetic process
AVL59_RS15140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AVL59_RS15150	COG1657	PFAM Prenyltransferase squalene oxidase
AVL59_RS15165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVL59_RS15170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVL59_RS15195	COG2365	Tyrosine phosphatase family
AVL59_RS15210	COG2755	lipolytic protein G-D-S-L family
AVL59_RS15230	COG1309	transcriptional regulator
AVL59_RS15235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AVL59_RS15270	COG1063	alcohol dehydrogenase
AVL59_RS15275	COG0156	8-amino-7-oxononanoate synthase activity
AVL59_RS15280	COG0583	DNA-binding transcription factor activity
AVL59_RS15300	COG3958	Transketolase
AVL59_RS15305	COG3959	Transketolase, thiamine diphosphate binding domain
AVL59_RS15325	COG0531	amino acid
AVL59_RS15345	COG0174	glutamine synthetase
AVL59_RS15355	COG0561	phosphatase activity
AVL59_RS15365	COG2267	carboxylic ester hydrolase activity
AVL59_RS15370	COG0183	Belongs to the thiolase family
AVL59_RS15375	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS15385	COG1011	Hydrolase
AVL59_RS15410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS15435	COG0604	alcohol dehydrogenase
AVL59_RS15435	COG3321	synthase
AVL59_RS15445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS15450	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AVL59_RS15455	COG0477	Major facilitator Superfamily
AVL59_RS15465	COG1278	Cold shock
AVL59_RS15485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS15500	COG3321	synthase
AVL59_RS15500	COG0604	alcohol dehydrogenase
AVL59_RS15510	COG0154	amidase activity
AVL59_RS15535	COG0395	ABC-type sugar transport system, permease component
AVL59_RS15540	COG1175	transmembrane transport
AVL59_RS15545	COG1653	transport
AVL59_RS15550	COG2188	Transcriptional regulator
AVL59_RS15555	COG3962	Belongs to the TPP enzyme family
AVL59_RS15585	COG0673	inositol 2-dehydrogenase activity
AVL59_RS15590	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS15595	COG1609	Transcriptional regulator
AVL59_RS15600	COG0673	inositol 2-dehydrogenase activity
AVL59_RS15605	COG1609	Transcriptional regulator
AVL59_RS15620	COG3485	protocatechuate 3,4-dioxygenase
AVL59_RS15630	COG0477	Major facilitator Superfamily
AVL59_RS15655	COG3938	Belongs to the proline racemase family
AVL59_RS15660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL59_RS15665	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL59_RS15690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS15695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS15725	COG2124	cytochrome p450
AVL59_RS15735	COG2838	Isocitrate dehydrogenase
AVL59_RS15750	COG0668	transmembrane transport
AVL59_RS15760	COG0531	amino acid
AVL59_RS15770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVL59_RS15785	COG1024	Enoyl-CoA hydratase
AVL59_RS15795	COG1132	(ABC) transporter
AVL59_RS15800	COG3469	chitinase activity
AVL59_RS15865	COG0745	RESPONSE REGULATOR receiver
AVL59_RS15875	COG0765	amino acid transport
AVL59_RS15880	COG1126	abc transporter atp-binding protein
AVL59_RS15890	COG0431	NADPH-dependent FMN reductase
AVL59_RS15920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS15935	COG0657	acetylesterase activity
AVL59_RS15970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVL59_RS15980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AVL59_RS16000	COG0297	glycogen (starch) synthase activity
AVL59_RS16005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AVL59_RS16010	COG3537	Alpha-1,2-mannosidase
AVL59_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS16060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS16080	COG0154	amidase activity
AVL59_RS16105	COG1175	transmembrane transport
AVL59_RS16110	COG0395	ABC-type sugar transport system, permease component
AVL59_RS16140	COG2186	Transcriptional regulator
AVL59_RS16145	COG1879	ABC-type sugar transport system periplasmic component
AVL59_RS16150	COG1129	ABC transporter
AVL59_RS16160	COG4948	Mandelate Racemase Muconate Lactonizing
AVL59_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS16180	COG3618	amidohydrolase
AVL59_RS16195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVL59_RS16220	COG0531	amino acid
AVL59_RS16280	COG0583	DNA-binding transcription factor activity
AVL59_RS16290	COG1053	succinate dehydrogenase
AVL59_RS16295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVL59_RS16320	COG0542	response to heat
AVL59_RS16325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS16345	COG2182	Extracellular solute-binding protein
AVL59_RS16350	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AVL59_RS16355	COG0121	glutamine amidotransferase
AVL59_RS16360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVL59_RS16385	COG2268	Band 7 protein
AVL59_RS16400	COG2814	Major facilitator Superfamily
AVL59_RS16405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS16420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL59_RS16425	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS16445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS16450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVL59_RS16455	COG0022	dehydrogenase e1 component
AVL59_RS16475	COG2814	Major facilitator Superfamily
AVL59_RS16510	COG1609	Transcriptional regulator
AVL59_RS16520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVL59_RS16530	COG0242	peptide deformylase activity
AVL59_RS16575	COG0395	ABC-type sugar transport system, permease component
AVL59_RS16580	COG1175	transmembrane transport
AVL59_RS16590	COG0454	-acetyltransferase
AVL59_RS16590	COG0456	acetyltransferase
AVL59_RS16595	COG3876	Protein conserved in bacteria
AVL59_RS16610	COG1309	transcriptional regulator
AVL59_RS16635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AVL59_RS16700	COG2755	lipolytic protein G-D-S-L family
AVL59_RS16735	COG2197	response regulator
AVL59_RS16735	COG3903	Transcriptional regulator
AVL59_RS16770	COG0151	Belongs to the GarS family
AVL59_RS16790	COG1404	Belongs to the peptidase S8 family
AVL59_RS16825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVL59_RS16865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL59_RS16990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVL59_RS17060	COG3387	PFAM Glycoside hydrolase 15-related
AVL59_RS17140	COG0515	serine threonine protein kinase
AVL59_RS17140	COG2815	serine threonine protein kinase
AVL59_RS17160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS17180	COG0604	alcohol dehydrogenase
AVL59_RS17185	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AVL59_RS17195	COG0542	response to heat
AVL59_RS17205	COG1174	glycine betaine transport
AVL59_RS17210	COG1174	glycine betaine transport
AVL59_RS17220	COG1125	glycine betaine transport
AVL59_RS17220	COG0517	IMP dehydrogenase activity
AVL59_RS17225	COG1556	Lactate utilization protein
AVL59_RS17230	COG1139	Iron-sulfur cluster binding protein
AVL59_RS17235	COG0247	lactate metabolic process
AVL59_RS17245	COG1609	Transcriptional regulator
AVL59_RS17265	COG1595	DNA-templated transcription, initiation
AVL59_RS17270	COG1357	PFAM Pentapeptide repeats (8 copies)
AVL59_RS17280	COG1309	transcriptional regulator
AVL59_RS17290	COG2706	6-phosphogluconolactonase activity
AVL59_RS17350	COG1796	DNA polymerase
AVL59_RS17350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AVL59_RS17365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVL59_RS17370	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS17410	COG0531	amino acid
AVL59_RS17445	COG2124	cytochrome p450
AVL59_RS17465	COG0667	Aldo Keto reductase
AVL59_RS17500	COG1595	DNA-templated transcription, initiation
AVL59_RS17510	COG3250	beta-galactosidase activity
AVL59_RS17515	COG2132	Multicopper oxidase
AVL59_RS17525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVL59_RS17585	COG1132	(ABC) transporter
AVL59_RS17620	COG2197	response regulator
AVL59_RS17625	COG1132	(ABC) transporter
AVL59_RS17630	COG1132	(ABC) transporter
AVL59_RS17640	COG0515	serine threonine protein kinase
AVL59_RS17655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVL59_RS17665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL59_RS17695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVL59_RS17695	COG3608	succinylglutamate desuccinylase aspartoacylase
AVL59_RS17760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL59_RS17775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVL59_RS17780	COG1231	oxidoreductase activity
AVL59_RS17800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS17825	COG1309	transcriptional regulator
AVL59_RS17830	COG0583	DNA-binding transcription factor activity
AVL59_RS17865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AVL59_RS17965	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AVL59_RS17975	COG0642	Histidine kinase
AVL59_RS17985	COG0671	phosphoesterase, PA-phosphatase related
AVL59_RS17995	COG0586	Pfam SNARE associated Golgi protein
AVL59_RS18010	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AVL59_RS18045	COG1017	nitric oxide dioxygenase activity
AVL59_RS18045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVL59_RS18050	COG0596	Alpha beta hydrolase
AVL59_RS18065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS18075	COG3387	PFAM Glycoside hydrolase 15-related
AVL59_RS18085	COG3290	protein histidine kinase activity
AVL59_RS18100	COG2045	Belongs to the ComB family
AVL59_RS18170	COG1254	Belongs to the acylphosphatase family
AVL59_RS18175	COG0456	acetyltransferase
AVL59_RS18205	COG0584	glycerophosphoryl diester phosphodiesterase
AVL59_RS18215	COG0667	Aldo Keto reductase
AVL59_RS18225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AVL59_RS18245	COG3469	chitinase activity
AVL59_RS18270	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS18305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL59_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS18325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS18365	COG4585	Histidine kinase
AVL59_RS18370	COG2197	response regulator
AVL59_RS18380	COG0589	response to stress
AVL59_RS18390	COG0516	GMP reductase activity
AVL59_RS18390	COG0517	IMP dehydrogenase activity
AVL59_RS18400	COG0583	DNA-binding transcription factor activity
AVL59_RS18460	COG0726	polysaccharide deacetylase
AVL59_RS18480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVL59_RS18490	COG2205	protein histidine kinase activity
AVL59_RS18495	COG0745	RESPONSE REGULATOR receiver
AVL59_RS18500	COG0477	Major facilitator Superfamily
AVL59_RS18505	COG1309	transcriptional regulator
AVL59_RS18520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS18530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS18545	COG0583	DNA-binding transcription factor activity
AVL59_RS18625	COG2124	cytochrome p450
AVL59_RS18650	COG1733	regulation of RNA biosynthetic process
AVL59_RS18735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVL59_RS18745	COG2318	DinB family
AVL59_RS18760	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS18780	COG1309	transcriptional regulator
AVL59_RS18800	COG4213	ABC transporter substrate-binding protein
AVL59_RS18810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL59_RS18810	COG2080	2 iron, 2 sulfur cluster binding
AVL59_RS18915	COG0477	Major facilitator Superfamily
AVL59_RS18920	COG1396	sequence-specific DNA binding
AVL59_RS18965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL59_RS18995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS19015	COG2124	cytochrome p450
AVL59_RS19025	COG3265	gluconokinase activity
AVL59_RS19035	COG1294	oxidase, subunit
AVL59_RS19040	COG1271	oxidase subunit
AVL59_RS19045	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS19050	COG3387	PFAM Glycoside hydrolase 15-related
AVL59_RS19090	COG1522	sequence-specific DNA binding
AVL59_RS19115	COG2271	Major facilitator Superfamily
AVL59_RS19130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVL59_RS19140	COG0300	oxidoreductase activity
AVL59_RS19150	COG1733	regulation of RNA biosynthetic process
AVL59_RS19165	COG0367	asparagine synthase
AVL59_RS19185	COG2124	cytochrome p450
AVL59_RS19205	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AVL59_RS19210	COG0477	Major facilitator Superfamily
AVL59_RS19250	COG0475	glutathione-regulated potassium exporter activity
AVL59_RS19300	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS19305	COG1733	regulation of RNA biosynthetic process
AVL59_RS19310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVL59_RS19315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL59_RS19360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVL59_RS19375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AVL59_RS19405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AVL59_RS19410	COG1687	branched-chain amino acid
AVL59_RS19420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVL59_RS19435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AVL59_RS19485	COG0604	alcohol dehydrogenase
AVL59_RS19485	COG3321	synthase
AVL59_RS19500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL59_RS19520	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS19550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVL59_RS19555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS19555	COG0515	serine threonine protein kinase
AVL59_RS19580	COG0300	oxidoreductase activity
AVL59_RS19595	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS19605	COG3842	ATPase activity
AVL59_RS19610	COG1177	transmembrane transport
AVL59_RS19615	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVL59_RS19635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AVL59_RS19645	COG0045	succinate-CoA ligase (ADP-forming) activity
AVL59_RS19645	COG1042	CoA-binding domain protein
AVL59_RS19645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS19650	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS19665	COG1309	transcriptional regulator
AVL59_RS19685	COG3321	synthase
AVL59_RS19685	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS19685	COG0604	alcohol dehydrogenase
AVL59_RS19690	COG0640	Transcriptional regulator
AVL59_RS19700	COG0277	FAD linked oxidase domain protein
AVL59_RS19720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVL59_RS19740	COG2080	2 iron, 2 sulfur cluster binding
AVL59_RS19745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AVL59_RS19750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL59_RS19755	COG3608	succinylglutamate desuccinylase aspartoacylase
AVL59_RS19755	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVL59_RS19775	COG0531	amino acid
AVL59_RS19830	COG1032	radical SAM domain protein
AVL59_RS19865	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS19865	COG2208	phosphoserine phosphatase activity
AVL59_RS19865	COG2172	sigma factor antagonist activity
AVL59_RS19870	COG3537	Alpha-1,2-mannosidase
AVL59_RS19880	COG1595	DNA-templated transcription, initiation
AVL59_RS19890	COG0477	Major facilitator Superfamily
AVL59_RS19900	COG3973	AAA domain
AVL59_RS19965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVL59_RS19970	COG1509	lysine 2,3-aminomutase activity
AVL59_RS19995	COG0251	oxidation-reduction process
AVL59_RS20035	COG0515	serine threonine protein kinase
AVL59_RS20080	COG2197	response regulator
AVL59_RS20085	COG4585	Histidine kinase
AVL59_RS20095	COG1131	(ABC) transporter
AVL59_RS20140	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS20145	COG3629	intracellular signal transduction
AVL59_RS20145	COG3903	Transcriptional regulator
AVL59_RS20210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS20215	COG1216	Glycosyl transferase, family 2
AVL59_RS20220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL59_RS20235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVL59_RS20260	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS20265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AVL59_RS20275	COG2268	Band 7 protein
AVL59_RS20285	COG1132	(ABC) transporter
AVL59_RS20290	COG2197	response regulator
AVL59_RS20295	COG4585	Histidine kinase
AVL59_RS20350	COG3293	Transposase
AVL59_RS20410	COG0488	(ABC) transporter
AVL59_RS20540	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS20570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AVL59_RS20595	COG0583	DNA-binding transcription factor activity
AVL59_RS20660	COG2027	D-alanyl-D-alanine carboxypeptidase
AVL59_RS20720	COG0069	glutamate synthase activity
AVL59_RS20745	COG0515	serine threonine protein kinase
AVL59_RS20790	COG0384	phenazine biosynthesis protein PhzF
AVL59_RS20795	COG0640	Transcriptional regulator
AVL59_RS20845	COG0747	negative chemotaxis
AVL59_RS20850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVL59_RS20865	COG4608	Belongs to the ABC transporter superfamily
AVL59_RS20915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL59_RS20920	COG2207	Transcriptional regulator
AVL59_RS20935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVL59_RS20935	COG2080	2 iron, 2 sulfur cluster binding
AVL59_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS21000	COG0583	DNA-binding transcription factor activity
AVL59_RS21005	COG3293	Transposase
AVL59_RS21050	COG1404	Belongs to the peptidase S8 family
AVL59_RS21075	COG0456	acetyltransferase
AVL59_RS21150	COG2124	cytochrome p450
AVL59_RS21160	COG1733	regulation of RNA biosynthetic process
AVL59_RS21165	COG0702	epimerase
AVL59_RS21220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVL59_RS21225	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS21245	COG2124	cytochrome p450
AVL59_RS21255	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AVL59_RS21280	COG1618	nucleotide phosphatase activity, acting on free nucleotides
AVL59_RS21285	COG1881	PFAM PEBP family protein
AVL59_RS21290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVL59_RS21330	COG2249	NAD(P)H dehydrogenase (quinone) activity
AVL59_RS21345	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL59_RS21345	COG2319	Wd-40 repeat
AVL59_RS21380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL59_RS21415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AVL59_RS21510	COG1302	Protein conserved in bacteria
AVL59_RS21540	COG0300	oxidoreductase activity
AVL59_RS21710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS21750	COG0515	serine threonine protein kinase
AVL59_RS21760	COG1595	DNA-templated transcription, initiation
AVL59_RS21765	COG1090	epimerase
AVL59_RS21770	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AVL59_RS21810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVL59_RS21875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL59_RS21880	COG0483	inositol monophosphate 1-phosphatase activity
AVL59_RS21920	COG0583	DNA-binding transcription factor activity
AVL59_RS21970	COG3415	Transposase
AVL59_RS21970	COG2801	Transposase and inactivated derivatives
AVL59_RS21975	COG0702	epimerase
AVL59_RS22005	COG0789	Transcriptional regulator
AVL59_RS22105	COG1082	Xylose isomerase domain protein TIM barrel
AVL59_RS22170	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS22185	COG1819	glycosyl
AVL59_RS22205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS22210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS22250	COG3903	Transcriptional regulator
AVL59_RS22250	COG3629	intracellular signal transduction
AVL59_RS22255	COG2197	response regulator
AVL59_RS22265	COG1132	(ABC) transporter
AVL59_RS22270	COG1132	(ABC) transporter
AVL59_RS22295	COG0515	serine threonine protein kinase
AVL59_RS22305	COG1819	glycosyl
AVL59_RS22310	COG2945	thiolester hydrolase activity
AVL59_RS22310	COG0596	Alpha beta hydrolase
AVL59_RS22315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS22435	COG2963	transposase activity
AVL59_RS22445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVL59_RS22470	COG1595	DNA-templated transcription, initiation
AVL59_RS22485	COG3655	Transcriptional regulator
AVL59_RS22495	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS22755	COG4104	PAAR repeat-containing protein
AVL59_RS22755	COG3209	COG3209 Rhs family protein
AVL59_RS22905	COG2124	cytochrome p450
AVL59_RS22975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS23010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVL59_RS23030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS23060	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS23070	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS23080	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS23090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL59_RS23100	COG0165	Argininosuccinate lyase
AVL59_RS23115	COG3293	Transposase
AVL59_RS23250	COG3340	Belongs to the peptidase S51 family
AVL59_RS23300	COG2197	response regulator
AVL59_RS23345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS23350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS23375	COG0251	oxidation-reduction process
AVL59_RS23405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AVL59_RS23430	COG1595	DNA-templated transcription, initiation
AVL59_RS23455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVL59_RS23460	COG0166	Belongs to the GPI family
AVL59_RS23465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AVL59_RS23470	COG0363	glucosamine-6-phosphate deaminase activity
AVL59_RS23495	COG1621	beta-fructofuranosidase activity
AVL59_RS23505	COG1175	transmembrane transport
AVL59_RS23510	COG0395	ABC-type sugar transport system, permease component
AVL59_RS23515	COG1621	beta-fructofuranosidase activity
AVL59_RS23520	COG1609	Transcriptional regulator
AVL59_RS23535	COG1733	regulation of RNA biosynthetic process
AVL59_RS23590	COG0583	DNA-binding transcription factor activity
AVL59_RS23645	COG0477	Major facilitator Superfamily
AVL59_RS23650	COG1802	Transcriptional regulator
AVL59_RS23665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVL59_RS23670	COG0066	3-isopropylmalate dehydratase activity
AVL59_RS23675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS23680	COG0587	DNA-directed DNA polymerase activity
AVL59_RS23730	COG1609	Transcriptional regulator
AVL59_RS23735	COG1653	transport
AVL59_RS23750	COG0366	Alpha amylase catalytic
AVL59_RS23755	COG1940	carbohydrate kinase activity
AVL59_RS23755	COG1846	Transcriptional regulator
AVL59_RS23805	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS23845	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS23945	COG0477	Major facilitator Superfamily
AVL59_RS23960	COG4974	Belongs to the 'phage' integrase family
AVL59_RS23985	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS24005	COG0477	Major facilitator Superfamily
AVL59_RS24045	COG1733	regulation of RNA biosynthetic process
AVL59_RS24060	COG0154	amidase activity
AVL59_RS24155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVL59_RS24170	COG2815	serine threonine protein kinase
AVL59_RS24170	COG0515	serine threonine protein kinase
AVL59_RS24195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS24210	COG1022	Amp-dependent synthetase and ligase
AVL59_RS24250	COG0367	asparagine synthase
AVL59_RS24255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVL59_RS24265	COG0657	acetylesterase activity
AVL59_RS24270	COG2072	flavoprotein involved in K transport
AVL59_RS24290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVL59_RS24295	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS24300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS24305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVL59_RS24310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVL59_RS24320	COG0736	holo-[acyl-carrier-protein] synthase activity
AVL59_RS24340	COG2409	Drug exporters of the RND superfamily
AVL59_RS24370	COG3384	dioxygenase
AVL59_RS24385	COG1695	Transcriptional regulator
AVL59_RS24430	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS24450	COG0542	response to heat
AVL59_RS24475	COG0202	RNA polymerase activity
AVL59_RS24590	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL59_RS24610	COG4585	Histidine kinase
AVL59_RS24615	COG2197	response regulator
AVL59_RS24640	COG1414	Transcriptional regulator
AVL59_RS24655	COG3629	intracellular signal transduction
AVL59_RS24655	COG3903	Transcriptional regulator
AVL59_RS24660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVL59_RS24720	COG1733	regulation of RNA biosynthetic process
AVL59_RS24730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVL59_RS24795	COG2318	DinB family
AVL59_RS24815	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS24860	COG1404	Belongs to the peptidase S8 family
AVL59_RS24885	COG1595	DNA-templated transcription, initiation
AVL59_RS24890	COG1131	(ABC) transporter
AVL59_RS24915	COG0142	geranyltranstransferase activity
AVL59_RS25005	COG2197	response regulator
AVL59_RS25020	COG0577	efflux transmembrane transporter activity
AVL59_RS25020	COG1136	(ABC) transporter
AVL59_RS25025	COG0577	efflux transmembrane transporter activity
AVL59_RS25095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVL59_RS25130	COG2207	Transcriptional regulator
AVL59_RS25140	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS25145	COG4221	oxidoreductase activity
AVL59_RS25160	COG1376	ErfK ybiS ycfS ynhG family protein
AVL59_RS25205	COG5640	endopeptidase activity
AVL59_RS25215	COG0789	Transcriptional regulator
AVL59_RS25240	COG2130	NADP-dependent
AVL59_RS25250	COG0419	ATPase involved in DNA repair
AVL59_RS25275	COG2124	cytochrome p450
AVL59_RS25315	COG0667	Aldo Keto reductase
AVL59_RS25320	COG1309	transcriptional regulator
AVL59_RS25340	COG3402	PFAM membrane-flanked domain
AVL59_RS25380	COG0277	FAD linked oxidase domain protein
AVL59_RS25400	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS25440	COG0431	NADPH-dependent FMN reductase
AVL59_RS25470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AVL59_RS25475	COG1051	belongs to the nudix hydrolase family
AVL59_RS25500	COG0745	RESPONSE REGULATOR receiver
AVL59_RS25560	COG0667	Aldo Keto reductase
AVL59_RS25595	COG1335	isochorismatase
AVL59_RS25630	COG1024	Enoyl-CoA hydratase
AVL59_RS25640	COG0243	molybdopterin cofactor binding
AVL59_RS25645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVL59_RS25655	COG2409	Drug exporters of the RND superfamily
AVL59_RS25660	COG1309	transcriptional regulator
AVL59_RS25670	COG0697	spore germination
AVL59_RS25685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVL59_RS25685	COG3608	succinylglutamate desuccinylase aspartoacylase
AVL59_RS25690	COG0531	amino acid
AVL59_RS25740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVL59_RS25745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVL59_RS25760	COG4176	ABC-type proline glycine betaine transport system permease component
AVL59_RS25765	COG4175	Glycine betaine
AVL59_RS25765	COG0517	IMP dehydrogenase activity
AVL59_RS25770	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS25785	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVL59_RS25795	COG4638	Rieske (2fe-2S)
AVL59_RS25800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVL59_RS25810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS25890	COG2267	carboxylic ester hydrolase activity
AVL59_RS25900	COG1733	regulation of RNA biosynthetic process
AVL59_RS25910	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS25915	COG1414	Transcriptional regulator
AVL59_RS25930	COG1309	transcriptional regulator
AVL59_RS25940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVL59_RS25985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVL59_RS25990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL59_RS25995	COG0019	diaminopimelate decarboxylase activity
AVL59_RS26000	COG1266	CAAX protease self-immunity
AVL59_RS26010	COG2197	response regulator
AVL59_RS26020	COG2409	Drug exporters of the RND superfamily
AVL59_RS26030	COG4977	sequence-specific DNA binding
AVL59_RS26045	COG2340	Cysteine-rich secretory protein family
AVL59_RS26090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVL59_RS26095	COG1414	Transcriptional regulator
AVL59_RS26115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL59_RS26130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AVL59_RS26160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS26165	COG1597	lipid kinase activity
AVL59_RS26170	COG0277	FAD linked oxidase domain protein
AVL59_RS26200	COG0367	asparagine synthase
AVL59_RS26205	COG2814	Major facilitator Superfamily
AVL59_RS26210	COG1120	ATPase activity
AVL59_RS26215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVL59_RS26270	COG1309	transcriptional regulator
AVL59_RS26300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVL59_RS26315	COG3842	ATPase activity
AVL59_RS26320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVL59_RS26325	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVL59_RS26330	COG1177	transmembrane transport
AVL59_RS26370	COG2124	cytochrome p450
AVL59_RS26390	COG1309	transcriptional regulator
AVL59_RS26395	COG5640	endopeptidase activity
AVL59_RS26400	COG0583	DNA-binding transcription factor activity
AVL59_RS26415	COG0586	Pfam SNARE associated Golgi protein
AVL59_RS26435	COG0583	DNA-binding transcription factor activity
AVL59_RS26450	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AVL59_RS26475	COG0375	protein maturation
AVL59_RS26490	COG0298	carbon dioxide binding
AVL59_RS26495	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AVL59_RS26505	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AVL59_RS26510	COG1024	Enoyl-CoA hydratase
AVL59_RS26510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVL59_RS26560	COG0657	acetylesterase activity
AVL59_RS26565	COG1609	Transcriptional regulator
AVL59_RS26620	COG0667	Aldo Keto reductase
AVL59_RS26640	COG0586	Pfam SNARE associated Golgi protein
AVL59_RS26650	COG2814	Major facilitator Superfamily
AVL59_RS26665	COG1921	L-seryl-tRNASec selenium transferase activity
AVL59_RS26705	COG3291	Pkd domain containing protein
AVL59_RS26710	COG0583	DNA-binding transcription factor activity
AVL59_RS26715	COG0667	Aldo Keto reductase
AVL59_RS26730	COG1733	regulation of RNA biosynthetic process
AVL59_RS26755	COG4257	antibiotic catabolic process
AVL59_RS26775	COG3001	Fructosamine kinase
AVL59_RS26800	COG2205	protein histidine kinase activity
AVL59_RS26840	COG2124	cytochrome p450
AVL59_RS26850	COG0009	L-threonylcarbamoyladenylate synthase
AVL59_RS26870	COG2130	NADP-dependent
AVL59_RS26875	COG0789	Transcriptional regulator
AVL59_RS26905	COG0701	Predicted permease
AVL59_RS26910	COG0640	Transcriptional regulator
AVL59_RS26915	COG2814	Major facilitator Superfamily
AVL59_RS26925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVL59_RS26960	COG1132	(ABC) transporter
AVL59_RS27015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVL59_RS27040	COG0181	hydroxymethylbilane synthase activity
AVL59_RS27050	COG0842	Transport permease protein
AVL59_RS27100	COG0366	Alpha amylase catalytic
AVL59_RS27110	COG3281	Trehalose synthase
AVL59_RS27115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVL59_RS27120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AVL59_RS27190	COG5002	protein histidine kinase activity
AVL59_RS27210	COG3189	MarR family transcriptional regulator
AVL59_RS27270	COG1672	PFAM Archaeal ATPase
AVL59_RS27270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AVL59_RS27275	COG3401	FG-GAP repeat protein
AVL59_RS27275	COG2755	lipolytic protein G-D-S-L family
AVL59_RS27285	COG3345	alpha-galactosidase
AVL59_RS27290	COG1940	carbohydrate kinase activity
AVL59_RS27290	COG1846	Transcriptional regulator
AVL59_RS27305	COG2340	Cysteine-rich secretory protein family
AVL59_RS27320	COG0142	geranyltranstransferase activity
AVL59_RS27325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVL59_RS27330	COG0515	serine threonine protein kinase
AVL59_RS27330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS27345	COG3647	Membrane
AVL59_RS27355	COG0667	Aldo Keto reductase
AVL59_RS27370	COG0583	DNA-binding transcription factor activity
AVL59_RS27380	COG2814	Major facilitator Superfamily
AVL59_RS27395	COG0328	RNA-DNA hybrid ribonuclease activity
AVL59_RS27405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL59_RS27415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL59_RS27425	COG0596	Alpha beta hydrolase
AVL59_RS27430	COG1396	sequence-specific DNA binding
AVL59_RS27435	COG1191	sigma factor activity
AVL59_RS27455	COG0515	serine threonine protein kinase
AVL59_RS27455	COG2815	serine threonine protein kinase
AVL59_RS27465	COG1716	ATPase activity
AVL59_RS27465	COG1131	(ABC) transporter
AVL59_RS27465	COG0842	Transport permease protein
AVL59_RS27495	COG0667	Aldo Keto reductase
AVL59_RS27500	COG0583	DNA-binding transcription factor activity
AVL59_RS27515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL59_RS27520	COG0346	lactoylglutathione lyase activity
AVL59_RS27540	COG0667	Aldo Keto reductase
AVL59_RS27550	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS27555	COG4941	Belongs to the sigma-70 factor family
AVL59_RS27575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS27590	COG1595	DNA-templated transcription, initiation
AVL59_RS27610	COG0531	amino acid
AVL59_RS27615	COG1940	carbohydrate kinase activity
AVL59_RS27620	COG3250	beta-galactosidase activity
AVL59_RS27670	COG0367	asparagine synthase
AVL59_RS27675	COG2267	carboxylic ester hydrolase activity
AVL59_RS27685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS27685	COG3320	Male sterility
AVL59_RS27690	COG0604	alcohol dehydrogenase
AVL59_RS27690	COG3321	synthase
AVL59_RS27695	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS27705	COG0673	inositol 2-dehydrogenase activity
AVL59_RS27710	COG3511	phospholipase C
AVL59_RS27730	COG0510	thiamine kinase activity
AVL59_RS27800	COG0596	Alpha beta hydrolase
AVL59_RS27815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS27835	COG2814	Major facilitator Superfamily
AVL59_RS27845	COG0640	Transcriptional regulator
AVL59_RS27885	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS27890	COG2124	cytochrome p450
AVL59_RS27910	COG2070	2-Nitropropane dioxygenase
AVL59_RS27915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVL59_RS27925	COG0515	serine threonine protein kinase
AVL59_RS27935	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS27960	COG3961	Belongs to the TPP enzyme family
AVL59_RS27965	COG1231	oxidoreductase activity
AVL59_RS27975	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AVL59_RS27980	COG0640	Transcriptional regulator
AVL59_RS27990	COG2376	Dihydroxyacetone kinase
AVL59_RS27995	COG1461	Dihydroxyacetone kinase
AVL59_RS28000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVL59_RS28000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVL59_RS28000	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AVL59_RS28025	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVL59_RS28025	COG1902	pentaerythritol trinitrate reductase activity
AVL59_RS28050	COG2890	protein-(glutamine-N5) methyltransferase activity
AVL59_RS28060	COG0714	Associated with various cellular activities
AVL59_RS28080	COG1214	PFAM Peptidase M22, glycoprotease
AVL59_RS28080	COG0456	acetyltransferase
AVL59_RS28090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVL59_RS28105	COG3458	cephalosporin-C deacetylase activity
AVL59_RS28110	COG2188	Transcriptional regulator
AVL59_RS28115	COG2226	methyltransferase
AVL59_RS28140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVL59_RS28160	COG2066	Belongs to the glutaminase family
AVL59_RS28170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AVL59_RS28175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVL59_RS28185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVL59_RS28200	COG1113	amino acid transport
AVL59_RS28205	COG2186	Transcriptional regulator
AVL59_RS28210	COG1968	undecaprenyl-diphosphatase activity
AVL59_RS28215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVL59_RS28220	COG1993	acr, cog1993
AVL59_RS28225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVL59_RS28240	COG2197	response regulator
AVL59_RS28260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVL59_RS28310	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS28385	COG2267	carboxylic ester hydrolase activity
AVL59_RS28400	COG2223	nitrite transmembrane transporter activity
AVL59_RS28430	COG0525	valine-tRNA ligase activity
AVL59_RS28465	COG3629	intracellular signal transduction
AVL59_RS28465	COG3903	Transcriptional regulator
AVL59_RS28470	COG1476	TRANSCRIPTIONal
AVL59_RS28485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS28485	COG0515	serine threonine protein kinase
AVL59_RS28525	COG0590	tRNA wobble adenosine to inosine editing
AVL59_RS28575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL59_RS28630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVL59_RS28645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL59_RS28650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVL59_RS28660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVL59_RS28690	COG0702	epimerase
AVL59_RS28705	COG0142	geranyltranstransferase activity
AVL59_RS28725	COG4221	oxidoreductase activity
AVL59_RS28765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVL59_RS28775	COG1864	DNA RNA non-specific endonuclease
AVL59_RS28775	COG3591	Belongs to the peptidase S1B family
AVL59_RS28825	COG0702	epimerase
AVL59_RS28835	COG4948	Mandelate Racemase Muconate Lactonizing
AVL59_RS28840	COG3265	gluconokinase activity
AVL59_RS28860	COG5640	endopeptidase activity
AVL59_RS28875	COG2267	carboxylic ester hydrolase activity
AVL59_RS28895	COG2172	sigma factor antagonist activity
AVL59_RS28895	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS28895	COG2208	phosphoserine phosphatase activity
AVL59_RS28900	COG0523	cobalamin synthesis protein
AVL59_RS28920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS28940	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AVL59_RS28945	COG2188	Transcriptional regulator
AVL59_RS28950	COG2175	clavaminate synthase activity
AVL59_RS28955	COG1116	anion transmembrane transporter activity
AVL59_RS28965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVL59_RS28970	COG3537	Alpha-1,2-mannosidase
AVL59_RS29025	COG0477	Major facilitator Superfamily
AVL59_RS29040	COG1846	Transcriptional regulator
AVL59_RS29055	COG3629	intracellular signal transduction
AVL59_RS29055	COG3903	Transcriptional regulator
AVL59_RS29065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL59_RS29080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AVL59_RS29085	COG2171	N-acyltransferase activity
AVL59_RS29105	COG0302	gtp cyclohydrolase
AVL59_RS29160	COG2018	Roadblock/LC7 domain
AVL59_RS29180	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS29185	COG2130	NADP-dependent
AVL59_RS29195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL59_RS29200	COG3537	Alpha-1,2-mannosidase
AVL59_RS29225	COG1131	(ABC) transporter
AVL59_RS29230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL59_RS29235	COG3170	Tfp pilus assembly protein FimV
AVL59_RS29265	COG0477	Major facilitator Superfamily
AVL59_RS29280	COG1309	transcriptional regulator
AVL59_RS29295	COG1376	ErfK ybiS ycfS ynhG family protein
AVL59_RS29315	COG0586	Pfam SNARE associated Golgi protein
AVL59_RS29320	COG0745	RESPONSE REGULATOR receiver
AVL59_RS29325	COG2205	protein histidine kinase activity
AVL59_RS29330	COG0642	Histidine kinase
AVL59_RS29335	COG0745	RESPONSE REGULATOR receiver
AVL59_RS29350	COG0019	diaminopimelate decarboxylase activity
AVL59_RS29365	COG0671	phosphoesterase, PA-phosphatase related
AVL59_RS29370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL59_RS29390	COG1216	Glycosyl transferase, family 2
AVL59_RS29395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVL59_RS29405	COG2205	protein histidine kinase activity
AVL59_RS29415	COG4181	ATPase activity
AVL59_RS29420	COG1136	(ABC) transporter
AVL59_RS29430	COG0745	RESPONSE REGULATOR receiver
AVL59_RS29435	COG3971	2-oxopent-4-enoate hydratase activity
AVL59_RS29550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS29555	COG2072	flavoprotein involved in K transport
AVL59_RS29575	COG0604	alcohol dehydrogenase
AVL59_RS29595	COG0028	Belongs to the TPP enzyme family
AVL59_RS29620	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS29625	COG1051	belongs to the nudix hydrolase family
AVL59_RS29640	COG0583	DNA-binding transcription factor activity
AVL59_RS29650	COG2814	Major facilitator Superfamily
AVL59_RS29670	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS29705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVL59_RS29710	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS29745	COG1349	DNA-binding transcription factor activity
AVL59_RS29775	COG1136	(ABC) transporter
AVL59_RS29805	COG1940	carbohydrate kinase activity
AVL59_RS29815	COG2813	Specifically methylates the guanine in position
AVL59_RS29825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVL59_RS29830	COG1349	DNA-binding transcription factor activity
AVL59_RS29890	COG2197	response regulator
AVL59_RS29895	COG4585	Histidine kinase
AVL59_RS29920	COG0492	ferredoxin-NADP+ reductase activity
AVL59_RS29950	COG1660	Displays ATPase and GTPase activities
AVL59_RS29960	COG3345	alpha-galactosidase
AVL59_RS29980	COG0515	serine threonine protein kinase
AVL59_RS29995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AVL59_RS30020	COG0204	Acyl-transferase
AVL59_RS30060	COG0584	glycerophosphoryl diester phosphodiesterase
AVL59_RS30075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL59_RS30085	COG0667	Aldo Keto reductase
AVL59_RS30110	COG0671	phosphoesterase, PA-phosphatase related
AVL59_RS30115	COG0546	phosphoglycolate phosphatase activity
AVL59_RS30135	COG2233	PERMEase
AVL59_RS30140	COG0640	Transcriptional regulator
AVL59_RS30145	COG1902	pentaerythritol trinitrate reductase activity
AVL59_RS30160	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS30180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVL59_RS30195	COG2706	6-phosphogluconolactonase activity
AVL59_RS30230	COG0531	amino acid
AVL59_RS30285	COG0038	chloride channel
AVL59_RS30345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVL59_RS30360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL59_RS30365	COG2091	lysine biosynthetic process via aminoadipic acid
AVL59_RS30380	COG0475	glutathione-regulated potassium exporter activity
AVL59_RS30385	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS30430	COG0477	Major facilitator Superfamily
AVL59_RS30520	COG1222	aaa ATPase
AVL59_RS30560	COG0714	Associated with various cellular activities
AVL59_RS30585	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVL59_RS30590	COG1129	ABC transporter
AVL59_RS30605	COG1278	Cold shock
AVL59_RS30610	COG0513	Belongs to the DEAD box helicase family
AVL59_RS30655	COG1278	Cold shock
AVL59_RS30665	COG1104	cysteine desulfurase activity
AVL59_RS30670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS30715	COG2272	Belongs to the type-B carboxylesterase lipase family
AVL59_RS30725	COG2197	response regulator
AVL59_RS30730	COG4585	Histidine kinase
AVL59_RS30770	COG1231	oxidoreductase activity
AVL59_RS30810	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS30825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL59_RS30830	COG1116	anion transmembrane transporter activity
AVL59_RS30840	COG2072	flavoprotein involved in K transport
AVL59_RS30845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AVL59_RS30850	COG1132	(ABC) transporter
AVL59_RS30875	COG1132	(ABC) transporter
AVL59_RS30880	COG1132	(ABC) transporter
AVL59_RS30890	COG0254	rRNA binding
AVL59_RS30905	COG1946	Acyl-CoA thioesterase
AVL59_RS30915	COG2018	Roadblock/LC7 domain
AVL59_RS30940	COG0642	Histidine kinase
AVL59_RS30975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVL59_RS30995	COG2115	Belongs to the xylose isomerase family
AVL59_RS31005	COG1846	Transcriptional regulator
AVL59_RS31005	COG1940	carbohydrate kinase activity
AVL59_RS31030	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS31035	COG0667	Aldo Keto reductase
AVL59_RS31055	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL59_RS31055	COG0596	Alpha beta hydrolase
AVL59_RS31085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVL59_RS31095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AVL59_RS31115	COG0367	asparagine synthase
AVL59_RS31140	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS31150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVL59_RS31165	COG4310	Domain of unknown function (DUF2172)
AVL59_RS31175	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS31185	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AVL59_RS31190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVL59_RS31215	COG0019	diaminopimelate decarboxylase activity
AVL59_RS31235	COG5002	protein histidine kinase activity
AVL59_RS31240	COG0745	RESPONSE REGULATOR receiver
AVL59_RS31260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVL59_RS31265	COG1725	Transcriptional regulator
AVL59_RS31330	COG0477	Major facilitator Superfamily
AVL59_RS31340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AVL59_RS31345	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS31360	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS31365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS31390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS31410	COG4221	oxidoreductase activity
AVL59_RS31460	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS31465	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS31480	COG1793	dna ligase
AVL59_RS31490	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS31505	COG3424	synthase
AVL59_RS31510	COG2124	cytochrome p450
AVL59_RS31520	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS31530	COG0242	peptide deformylase activity
AVL59_RS31540	COG3442	glutamine amidotransferase
AVL59_RS31545	COG0205	6-phosphofructokinase activity
AVL59_RS31555	COG1522	sequence-specific DNA binding
AVL59_RS31560	COG1834	amidinotransferase
AVL59_RS31565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL59_RS31580	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVL59_RS31600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVL59_RS31605	COG0432	Pfam Uncharacterised protein family UPF0047
AVL59_RS31655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS31660	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AVL59_RS31670	COG0436	Aminotransferase
AVL59_RS31685	COG0829	nickel cation binding
AVL59_RS31690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVL59_RS31700	COG0804	urea catabolic process
AVL59_RS31705	COG0832	Belongs to the urease beta subunit family
AVL59_RS31710	COG0831	urea catabolic process
AVL59_RS31720	COG0740	serine-type endopeptidase activity
AVL59_RS31735	COG1280	lysine exporter protein (LysE YggA)
AVL59_RS31740	COG0583	DNA-binding transcription factor activity
AVL59_RS31765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVL59_RS31770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AVL59_RS31775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AVL59_RS31780	COG2226	methyltransferase
AVL59_RS31795	COG1136	(ABC) transporter
AVL59_RS31795	COG0577	efflux transmembrane transporter activity
AVL59_RS31800	COG0577	efflux transmembrane transporter activity
AVL59_RS31810	COG0456	acetyltransferase
AVL59_RS31870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVL59_RS31895	COG4585	Histidine kinase
AVL59_RS31900	COG2197	response regulator
AVL59_RS31905	COG1940	carbohydrate kinase activity
AVL59_RS31910	COG2188	Transcriptional regulator
AVL59_RS31915	COG1595	DNA-templated transcription, initiation
AVL59_RS31935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS31955	COG0626	cystathionine gamma-synthase activity
AVL59_RS31980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVL59_RS32000	COG1522	sequence-specific DNA binding
AVL59_RS32030	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS32035	COG1475	DNA binding
AVL59_RS32150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVL59_RS32155	COG0514	ATP-dependent DNA helicase (RecQ)
AVL59_RS32210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVL59_RS32215	COG0602	queuosine metabolic process
AVL59_RS32220	COG0720	synthase
AVL59_RS32270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVL59_RS32290	COG0017	Asparaginyl-tRNA synthetase
AVL59_RS32375	COG1132	(ABC) transporter
AVL59_RS32480	COG2319	Wd-40 repeat
AVL59_RS32480	COG4249	Peptidase C14 caspase catalytic subunit p20
AVL59_RS32515	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVL59_RS32585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS32595	COG0180	Tryptophanyl-tRNA synthetase
AVL59_RS32600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL59_RS32790	COG0419	ATPase involved in DNA repair
AVL59_RS32795	COG0420	3'-5' exonuclease activity
AVL59_RS32840	COG1739	Uncharacterized protein family UPF0029
AVL59_RS32865	COG1832	CoA-binding protein
AVL59_RS32870	COG0531	amino acid
AVL59_RS32890	COG0110	maltose O-acetyltransferase activity
AVL59_RS32920	COG0596	Alpha beta hydrolase
AVL59_RS32945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVL59_RS32975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVL59_RS32990	COG0183	Belongs to the thiolase family
AVL59_RS33020	COG0667	Aldo Keto reductase
AVL59_RS33045	COG1968	undecaprenyl-diphosphatase activity
AVL59_RS33060	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVL59_RS33070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS33090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVL59_RS33095	COG0747	negative chemotaxis
AVL59_RS33140	COG0697	spore germination
AVL59_RS33170	COG1695	Transcriptional regulator
AVL59_RS33180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS33195	COG0384	phenazine biosynthesis protein PhzF
AVL59_RS33250	COG3835	regulator
AVL59_RS33260	COG0725	ABC transporter, periplasmic molybdate-binding protein
AVL59_RS33275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVL59_RS33280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVL59_RS33280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVL59_RS33290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVL59_RS33310	COG1716	ATPase activity
AVL59_RS33330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVL59_RS33360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVL59_RS33375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS33380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVL59_RS33405	COG3706	GGDEF domain
AVL59_RS33410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AVL59_RS33415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVL59_RS33435	COG2018	Roadblock/LC7 domain
AVL59_RS33470	COG2814	Major facilitator Superfamily
AVL59_RS33475	COG4336	lyase activity
AVL59_RS33480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVL59_RS33485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVL59_RS33490	COG1984	allophanate hydrolase subunit 2
AVL59_RS33495	COG2755	lipolytic protein G-D-S-L family
AVL59_RS33500	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS33535	COG2364	Membrane
AVL59_RS33545	COG2270	Major facilitator Superfamily
AVL59_RS33560	COG1216	Glycosyl transferase, family 2
AVL59_RS33590	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS33645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVL59_RS33650	COG0140	phosphoribosyl-ATP diphosphatase activity
AVL59_RS33655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVL59_RS33660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVL59_RS33660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVL59_RS33665	COG3201	nicotinamide mononucleotide transporter
AVL59_RS33675	COG1595	DNA-templated transcription, initiation
AVL59_RS33685	COG1846	Transcriptional regulator
AVL59_RS33685	COG1940	carbohydrate kinase activity
AVL59_RS33690	COG0738	Major facilitator superfamily
AVL59_RS33705	COG2233	PERMEase
AVL59_RS33730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVL59_RS33760	COG3842	ATPase activity
AVL59_RS33770	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVL59_RS33780	COG2186	Transcriptional regulator
AVL59_RS33790	COG0531	amino acid
AVL59_RS33810	COG2390	Transcriptional regulator
AVL59_RS33815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVL59_RS33825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVL59_RS33840	COG0539	negative regulation of cytoplasmic translation
AVL59_RS33845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVL59_RS33860	COG0194	GDP metabolic process
AVL59_RS33870	COG0284	orotidine-5'-phosphate decarboxylase activity
AVL59_RS33875	COG0167	dihydroorotate dehydrogenase activity
AVL59_RS33880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVL59_RS33885	COG0505	Belongs to the CarA family
AVL59_RS33895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AVL59_RS33900	COG0540	Belongs to the ATCase OTCase family
AVL59_RS33905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AVL59_RS33915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVL59_RS33920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVL59_RS33925	COG0006	proline dipeptidase activity
AVL59_RS33935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVL59_RS33940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVL59_RS33945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVL59_RS33950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVL59_RS33960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVL59_RS33965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVL59_RS33985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVL59_RS34010	COG4585	Histidine kinase
AVL59_RS34015	COG2197	response regulator
AVL59_RS34020	COG0124	histidyl-tRNA synthetase
AVL59_RS34030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVL59_RS34035	COG1196	nuclear chromosome segregation
AVL59_RS34050	COG2815	serine threonine protein kinase
AVL59_RS34050	COG0515	serine threonine protein kinase
AVL59_RS34055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVL59_RS34060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVL59_RS34065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL59_RS34070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVL59_RS34080	COG2255	four-way junction helicase activity
AVL59_RS34085	COG0632	four-way junction helicase activity
AVL59_RS34090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVL59_RS34095	COG0217	transcriptional regulatory protein
AVL59_RS34100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AVL59_RS34105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AVL59_RS34115	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS34120	COG1560	Kdo2-lipid A biosynthetic process
AVL59_RS34125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVL59_RS34145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVL59_RS34160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVL59_RS34185	COG0596	Alpha beta hydrolase
AVL59_RS34230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVL59_RS34285	COG1648	precorrin-2 dehydrogenase activity
AVL59_RS34285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVL59_RS34290	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVL59_RS34305	COG1464	Belongs to the NlpA lipoprotein family
AVL59_RS34310	COG2011	ABC-type metal ion transport system permease component
AVL59_RS34315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AVL59_RS34350	COG0204	Acyl-transferase
AVL59_RS34350	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS34355	COG0477	Major facilitator Superfamily
AVL59_RS34370	COG0165	Argininosuccinate lyase
AVL59_RS34375	COG0137	argininosuccinate synthase activity
AVL59_RS34390	COG2205	protein histidine kinase activity
AVL59_RS34395	COG0745	RESPONSE REGULATOR receiver
AVL59_RS34430	COG1132	(ABC) transporter
AVL59_RS34450	COG1438	arginine binding
AVL59_RS34455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVL59_RS34460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVL59_RS34465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVL59_RS34470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVL59_RS34480	COG0463	Glycosyl transferase, family 2
AVL59_RS34500	COG0789	Transcriptional regulator
AVL59_RS34530	COG0697	spore germination
AVL59_RS34540	COG1649	PFAM Uncharacterised BCR, COG1649
AVL59_RS34570	COG0072	phenylalanine-tRNA ligase activity
AVL59_RS34570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVL59_RS34575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVL59_RS34580	COG5002	protein histidine kinase activity
AVL59_RS34585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVL59_RS34590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVL59_RS34595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVL59_RS34600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVL59_RS34645	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS34650	COG0174	glutamine synthetase
AVL59_RS34655	COG2186	Transcriptional regulator
AVL59_RS34660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AVL59_RS34685	COG4176	ABC-type proline glycine betaine transport system permease component
AVL59_RS34690	COG4175	Glycine betaine
AVL59_RS34690	COG0517	IMP dehydrogenase activity
AVL59_RS34695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVL59_RS34765	COG0805	protein transport
AVL59_RS34770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVL59_RS34800	COG0545	Peptidyl-prolyl cis-trans isomerase
AVL59_RS34805	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AVL59_RS34815	COG1609	Transcriptional regulator
AVL59_RS34820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AVL59_RS34825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AVL59_RS34840	COG4122	O-methyltransferase activity
AVL59_RS34845	COG1222	aaa ATPase
AVL59_RS34865	COG1994	Peptidase M50
AVL59_RS34865	COG0517	IMP dehydrogenase activity
AVL59_RS34875	COG2197	response regulator
AVL59_RS34880	COG0747	negative chemotaxis
AVL59_RS34885	COG0747	negative chemotaxis
AVL59_RS34890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVL59_RS34895	COG1410	methionine synthase
AVL59_RS34895	COG0646	methionine synthase
AVL59_RS34900	COG1414	Transcriptional regulator
AVL59_RS34905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AVL59_RS34910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVL59_RS34915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AVL59_RS34925	COG2186	Transcriptional regulator
AVL59_RS34935	COG0215	cysteine-tRNA ligase activity
AVL59_RS34955	COG0598	Magnesium transport protein CorA
AVL59_RS34965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS34970	COG0667	Aldo Keto reductase
AVL59_RS35010	COG1401	restriction endodeoxyribonuclease activity
AVL59_RS35025	COG0308	aminopeptidase N
AVL59_RS35040	COG3265	gluconokinase activity
AVL59_RS35045	COG2186	Transcriptional regulator
AVL59_RS35050	COG3012	SEC-C Motif Domain Protein
AVL59_RS35070	COG1796	DNA polymerase
AVL59_RS35070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AVL59_RS35095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AVL59_RS35100	COG2149	membrane
AVL59_RS35135	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS35145	COG3876	Protein conserved in bacteria
AVL59_RS35180	COG0789	Transcriptional regulator
AVL59_RS35200	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS35210	COG0640	Transcriptional regulator
AVL59_RS35245	COG0243	molybdopterin cofactor binding
AVL59_RS35250	COG1309	transcriptional regulator
AVL59_RS35260	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AVL59_RS35265	COG2188	Transcriptional regulator
AVL59_RS35310	COG1595	DNA-templated transcription, initiation
AVL59_RS35330	COG0515	serine threonine protein kinase
AVL59_RS35335	COG2755	lipolytic protein G-D-S-L family
AVL59_RS35345	COG0463	Glycosyl transferase, family 2
AVL59_RS35355	COG1649	PFAM Uncharacterised BCR, COG1649
AVL59_RS35355	COG0726	polysaccharide deacetylase
AVL59_RS35380	COG1725	Transcriptional regulator
AVL59_RS35415	COG3629	intracellular signal transduction
AVL59_RS35415	COG3903	Transcriptional regulator
AVL59_RS35425	COG0277	FAD linked oxidase domain protein
AVL59_RS35445	COG0587	DNA-directed DNA polymerase activity
AVL59_RS35475	COG1799	cell septum assembly
AVL59_RS35480	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS35485	COG0477	Major facilitator Superfamily
AVL59_RS35495	COG0671	phosphoesterase, PA-phosphatase related
AVL59_RS35525	COG1160	GTP binding
AVL59_RS35535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVL59_RS35560	COG3541	Predicted nucleotidyltransferase
AVL59_RS35575	COG1187	pseudouridine synthase activity
AVL59_RS35580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVL59_RS35585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVL59_RS35600	COG0686	Belongs to the AlaDH PNT family
AVL59_RS35610	COG0494	nUDIX hydrolase
AVL59_RS35615	COG0504	CTP synthase activity
AVL59_RS35620	COG3387	PFAM Glycoside hydrolase 15-related
AVL59_RS35625	COG0277	FAD linked oxidase domain protein
AVL59_RS35635	COG0297	glycogen (starch) synthase activity
AVL59_RS35645	COG0497	DNA recombination
AVL59_RS35655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVL59_RS35675	COG1120	ATPase activity
AVL59_RS35680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVL59_RS35685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVL59_RS35690	COG0647	UMP catabolic process
AVL59_RS35725	COG2094	Belongs to the DNA glycosylase MPG family
AVL59_RS35735	COG1881	PFAM PEBP family protein
AVL59_RS35760	COG1119	ATPase activity
AVL59_RS35775	COG2197	response regulator
AVL59_RS35785	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS35790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVL59_RS35800	COG1716	ATPase activity
AVL59_RS35800	COG1131	(ABC) transporter
AVL59_RS35800	COG0842	Transport permease protein
AVL59_RS35810	COG3830	Belongs to the UPF0237 family
AVL59_RS35810	COG0560	Phosphoserine phosphatase
AVL59_RS35815	COG0588	phosphoglycerate mutase activity
AVL59_RS35830	COG2186	Transcriptional regulator
AVL59_RS35845	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS35860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVL59_RS35865	COG2261	transglycosylase associated protein
AVL59_RS35880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVL59_RS35885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL59_RS35900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVL59_RS35910	COG1063	alcohol dehydrogenase
AVL59_RS35945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVL59_RS35960	COG3387	PFAM Glycoside hydrolase 15-related
AVL59_RS36000	COG1024	Enoyl-CoA hydratase
AVL59_RS36010	COG0488	(ABC) transporter
AVL59_RS36030	COG0235	Class ii aldolase
AVL59_RS36045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AVL59_RS36050	COG1492	cobalamin metabolic process
AVL59_RS36070	COG1797	cobyrinic acid a,c-diamide synthase activity
AVL59_RS36130	COG0765	amino acid transport
AVL59_RS36135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL59_RS36140	COG1104	cysteine desulfurase activity
AVL59_RS36145	COG2318	DinB family
AVL59_RS36150	COG0456	acetyltransferase
AVL59_RS36155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVL59_RS36160	COG1917	Cupin 2, conserved barrel domain protein
AVL59_RS36165	COG5285	phytanoyl-CoA dioxygenase
AVL59_RS36170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVL59_RS36205	COG1414	Transcriptional regulator
AVL59_RS36215	COG4585	Histidine kinase
AVL59_RS36220	COG2197	response regulator
AVL59_RS36230	COG2252	PERMEase
AVL59_RS36250	COG1802	Transcriptional regulator
AVL59_RS36255	COG1234	tRNA 3'-trailer cleavage
AVL59_RS36280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL59_RS36285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVL59_RS36290	COG1349	DNA-binding transcription factor activity
AVL59_RS36305	COG0395	ABC-type sugar transport system, permease component
AVL59_RS36310	COG1063	alcohol dehydrogenase
AVL59_RS36320	COG1309	transcriptional regulator
AVL59_RS36375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL59_RS36385	COG1595	DNA-templated transcription, initiation
AVL59_RS36395	COG2171	N-acyltransferase activity
AVL59_RS36400	COG3226	Transcriptional regulator
AVL59_RS36405	COG2076	Multidrug Resistance protein
AVL59_RS36410	COG2151	metal-sulfur cluster biosynthetic enzyme
AVL59_RS36415	COG0822	iron-sulfur transferase activity
AVL59_RS36420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVL59_RS36425	COG0396	ATPase activity
AVL59_RS36435	COG0719	Fe-S assembly protein
AVL59_RS36450	COG2746	aminoglycoside 3-N-acetyltransferase activity
AVL59_RS36455	COG1131	(ABC) transporter
AVL59_RS36465	COG1612	heme a metabolic process
AVL59_RS36485	COG0109	protoheme IX farnesyltransferase activity
AVL59_RS36495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVL59_RS36510	COG0363	glucosamine-6-phosphate deaminase activity
AVL59_RS36515	COG0395	ABC-type sugar transport system, permease component
AVL59_RS36520	COG1175	transmembrane transport
AVL59_RS36525	COG1653	transport
AVL59_RS36530	COG0366	Alpha amylase catalytic
AVL59_RS36535	COG1653	transport
AVL59_RS36540	COG1695	Transcriptional regulator
AVL59_RS36545	COG1136	(ABC) transporter
AVL59_RS36560	COG0166	Belongs to the GPI family
AVL59_RS36575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVL59_RS36580	COG0149	triose-phosphate isomerase activity
AVL59_RS36585	COG0126	phosphoglycerate kinase activity
AVL59_RS36590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVL59_RS36600	COG1481	regulation of sporulation
AVL59_RS36605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AVL59_RS36610	COG1660	Displays ATPase and GTPase activities
AVL59_RS36615	COG0322	excinuclease ABC activity
AVL59_RS36630	COG1609	Transcriptional regulator
AVL59_RS36640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVL59_RS36650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVL59_RS36655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL59_RS36660	COG0765	amino acid transport
AVL59_RS36670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVL59_RS36675	COG0477	Major facilitator Superfamily
AVL59_RS36680	COG0387	Pfam Sodium calcium exchanger
AVL59_RS36700	COG0556	nucleotide-excision repair
AVL59_RS36710	COG0584	glycerophosphoryl diester phosphodiesterase
AVL59_RS36715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVL59_RS36725	COG2313	pseudouridylate synthase activity
AVL59_RS36730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVL59_RS36730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AVL59_RS36735	COG2226	methyltransferase
AVL59_RS36740	COG0598	Magnesium transport protein CorA
AVL59_RS36760	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS36775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVL59_RS36780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS36815	COG0402	S-adenosylhomocysteine deaminase activity
AVL59_RS36840	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL59_RS36845	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS36880	COG0237	dephospho-CoA kinase activity
AVL59_RS36890	COG0539	negative regulation of cytoplasmic translation
AVL59_RS36900	COG1643	Atp-dependent helicase
AVL59_RS36935	COG2050	protein possibly involved in aromatic compounds catabolism
AVL59_RS36980	COG2968	Membrane
AVL59_RS36985	COG0737	Belongs to the 5'-nucleotidase family
AVL59_RS37005	COG0702	epimerase
AVL59_RS37015	COG0287	Prephenate dehydrogenase
AVL59_RS37015	COG1605	Chorismate mutase
AVL59_RS37035	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS37040	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS37045	COG1024	Enoyl-CoA hydratase
AVL59_RS37065	COG0183	Belongs to the thiolase family
AVL59_RS37070	COG1309	transcriptional regulator
AVL59_RS37080	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS37090	COG2304	oxidoreductase activity
AVL59_RS37105	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS37110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AVL59_RS37125	COG0067	glutamate synthase
AVL59_RS37125	COG0069	glutamate synthase activity
AVL59_RS37125	COG0070	glutamate synthase
AVL59_RS37155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL59_RS37160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AVL59_RS37165	COG2301	Belongs to the HpcH HpaI aldolase family
AVL59_RS37170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVL59_RS37180	COG0159	tryptophan synthase activity
AVL59_RS37185	COG0133	tryptophan synthase activity
AVL59_RS37195	COG0134	indole-3-glycerol-phosphate synthase activity
AVL59_RS37220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVL59_RS37245	COG0107	imidazoleglycerol-phosphate synthase activity
AVL59_RS37250	COG0251	oxidation-reduction process
AVL59_RS37255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVL59_RS37260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVL59_RS37265	COG0131	Imidazoleglycerol-phosphate dehydratase
AVL59_RS37270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL59_RS37275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVL59_RS37295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVL59_RS37315	COG1432	Conserved Protein
AVL59_RS37320	COG0587	DNA-directed DNA polymerase activity
AVL59_RS37365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVL59_RS37375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVL59_RS37380	COG3599	regulation of cell shape
AVL59_RS37390	COG1799	cell septum assembly
AVL59_RS37400	COG1496	oxidoreductase activity
AVL59_RS37405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVL59_RS37415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVL59_RS37425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVL59_RS37430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVL59_RS37440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVL59_RS37445	COG0768	penicillin binding
AVL59_RS37455	COG0275	rRNA processing
AVL59_RS37465	COG0714	Associated with various cellular activities
AVL59_RS37485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVL59_RS37495	COG1122	ATPase activity
AVL59_RS37505	COG1309	transcriptional regulator
AVL59_RS37530	COG0352	thiamine-phosphate diphosphorylase activity
AVL59_RS37550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL59_RS37550	COG2022	thiamine diphosphate biosynthetic process
AVL59_RS37560	COG2022	thiamine diphosphate biosynthetic process
AVL59_RS37565	COG2815	serine threonine protein kinase
AVL59_RS37565	COG0515	serine threonine protein kinase
AVL59_RS37570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AVL59_RS37580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVL59_RS37585	COG2193	ferroxidase activity
AVL59_RS37590	COG0243	molybdopterin cofactor binding
AVL59_RS37595	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AVL59_RS37605	COG0205	6-phosphofructokinase activity
AVL59_RS37615	COG4585	Histidine kinase
AVL59_RS37640	COG1940	carbohydrate kinase activity
AVL59_RS37650	COG0003	Pfam Anion-transporting ATPase
AVL59_RS37665	COG1022	Amp-dependent synthetase and ligase
AVL59_RS37690	COG0534	Mate efflux family protein
AVL59_RS37735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVL59_RS37740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVL59_RS37745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVL59_RS37750	COG0723	plastoquinol--plastocyanin reductase activity
AVL59_RS37755	COG2010	Cytochrome c
AVL59_RS37760	COG1845	cytochrome c oxidase, subunit III
AVL59_RS37770	COG1376	ErfK ybiS ycfS ynhG family protein
AVL59_RS37780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVL59_RS37785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVL59_RS37795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL59_RS37815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVL59_RS37825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVL59_RS37830	COG2197	response regulator
AVL59_RS37865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL59_RS37885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVL59_RS37890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVL59_RS37890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVL59_RS37905	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AVL59_RS37915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVL59_RS37920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVL59_RS37925	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVL59_RS37935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AVL59_RS37970	COG0456	acetyltransferase
AVL59_RS37975	COG1090	epimerase
AVL59_RS37990	COG0321	lipoyl(octanoyl) transferase activity
AVL59_RS37995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVL59_RS38015	COG0174	glutamine synthetase
AVL59_RS38035	COG0501	Belongs to the peptidase M48B family
AVL59_RS38070	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS38100	COG0745	RESPONSE REGULATOR receiver
AVL59_RS38105	COG1090	epimerase
AVL59_RS38115	COG2197	response regulator
AVL59_RS38145	COG1309	transcriptional regulator
AVL59_RS38165	COG0366	Alpha amylase catalytic
AVL59_RS38170	COG3833	ABC-type maltose transport systems, permease component
AVL59_RS38175	COG1175	transmembrane transport
AVL59_RS38185	COG1609	Transcriptional regulator
AVL59_RS38195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AVL59_RS38205	COG3511	phospholipase C
AVL59_RS38230	COG0174	glutamine synthetase
AVL59_RS38245	COG1959	2 iron, 2 sulfur cluster binding
AVL59_RS38285	COG2814	Major facilitator Superfamily
AVL59_RS38295	COG1309	transcriptional regulator
AVL59_RS38300	COG0477	Major facilitator Superfamily
AVL59_RS38305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVL59_RS38330	COG1994	Peptidase M50
AVL59_RS38385	COG2837	iron assimilation
AVL59_RS38390	COG0672	)-iron permease
AVL59_RS38415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVL59_RS38420	COG2814	Major facilitator Superfamily
AVL59_RS38430	COG1686	Belongs to the peptidase S11 family
AVL59_RS38435	COG0667	Aldo Keto reductase
AVL59_RS38445	COG2259	Doxx family
AVL59_RS38530	COG0557	exoribonuclease II activity
AVL59_RS38535	COG3022	response to hydroperoxide
AVL59_RS38540	COG0800	Aldolase
AVL59_RS38555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVL59_RS38565	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS38575	COG2030	dehydratase
AVL59_RS38580	COG4585	Histidine kinase
AVL59_RS38590	COG2197	response regulator
AVL59_RS38610	COG0183	Belongs to the thiolase family
AVL59_RS38615	COG0477	Major facilitator Superfamily
AVL59_RS38625	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVL59_RS38635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS38655	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS38660	COG1309	transcriptional regulator
AVL59_RS38690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVL59_RS38715	COG2423	ornithine cyclodeaminase activity
AVL59_RS38750	COG3845	ABC transporter
AVL59_RS38770	COG3619	membrane
AVL59_RS38775	COG2124	cytochrome p450
AVL59_RS38780	COG0183	Belongs to the thiolase family
AVL59_RS38820	COG4122	O-methyltransferase activity
AVL59_RS38845	COG2378	regulation of single-species biofilm formation
AVL59_RS38950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL59_RS38960	COG1358	cellular component organization or biogenesis
AVL59_RS39005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AVL59_RS39010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL59_RS39030	COG0789	Transcriptional regulator
AVL59_RS39060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVL59_RS39065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS39070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS39130	COG2130	NADP-dependent
AVL59_RS39135	COG1764	response to oxidative stress
AVL59_RS39140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVL59_RS39175	COG4214	carbohydrate transport
AVL59_RS39185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL59_RS39195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL59_RS39205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVL59_RS39240	COG3386	PFAM SMP-30 Gluconolaconase
AVL59_RS39245	COG1414	Transcriptional regulator
AVL59_RS39255	COG0300	oxidoreductase activity
AVL59_RS39260	COG0583	DNA-binding transcription factor activity
AVL59_RS39285	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS39290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVL59_RS39290	COG0825	malonyl-CoA metabolic process
AVL59_RS39315	COG1077	Cell shape determining protein MreB Mrl
AVL59_RS39390	COG1070	Carbohydrate kinase
AVL59_RS39405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVL59_RS39410	COG0358	DNA primase activity
AVL59_RS39420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AVL59_RS39430	COG2949	membrane
AVL59_RS39435	COG0243	molybdopterin cofactor binding
AVL59_RS39455	COG0477	Major facilitator Superfamily
AVL59_RS39475	COG1733	regulation of RNA biosynthetic process
AVL59_RS39485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVL59_RS39490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVL59_RS39490	COG2146	nitrite reductase [NAD(P)H] activity
AVL59_RS39500	COG1309	transcriptional regulator
AVL59_RS39505	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS39515	COG0395	ABC-type sugar transport system, permease component
AVL59_RS39520	COG1175	transmembrane transport
AVL59_RS39525	COG2182	Extracellular solute-binding protein
AVL59_RS39530	COG4221	oxidoreductase activity
AVL59_RS39580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVL59_RS39580	COG0574	Belongs to the PEP-utilizing enzyme family
AVL59_RS39585	COG1846	Transcriptional regulator
AVL59_RS39585	COG1940	carbohydrate kinase activity
AVL59_RS39590	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AVL59_RS39615	COG0477	Major facilitator Superfamily
AVL59_RS39650	COG0477	Major facilitator Superfamily
AVL59_RS39675	COG0667	Aldo Keto reductase
AVL59_RS39685	COG1280	lysine exporter protein (LysE YggA)
AVL59_RS39695	COG0423	glycine-tRNA ligase activity
AVL59_RS39705	COG1121	(ABC) transporter
AVL59_RS39710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVL59_RS39730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVL59_RS39735	COG1381	Involved in DNA repair and RecF pathway recombination
AVL59_RS39750	COG0747	negative chemotaxis
AVL59_RS39760	COG0444	Belongs to the ABC transporter superfamily
AVL59_RS39765	COG4608	Belongs to the ABC transporter superfamily
AVL59_RS39825	COG2197	response regulator
AVL59_RS39830	COG4585	Histidine kinase
AVL59_RS39835	COG2409	Drug exporters of the RND superfamily
AVL59_RS39845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVL59_RS39880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVL59_RS39890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVL59_RS39910	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVL59_RS39915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVL59_RS39930	COG1012	belongs to the aldehyde dehydrogenase family
AVL59_RS39940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS39995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVL59_RS40010	COG4948	Mandelate Racemase Muconate Lactonizing
AVL59_RS40015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVL59_RS40025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVL59_RS40030	COG1234	tRNA 3'-trailer cleavage
AVL59_RS40035	COG0537	adenosine 5'-monophosphoramidase activity
AVL59_RS40040	COG0793	Belongs to the peptidase S41A family
AVL59_RS40040	COG4946	Tricorn protease homolog
AVL59_RS40065	COG0484	heat shock protein binding
AVL59_RS40070	COG1420	regulation of RNA biosynthetic process
AVL59_RS40105	COG0481	GTPase activity
AVL59_RS40110	COG0268	Binds directly to 16S ribosomal RNA
AVL59_RS40150	COG1307	EDD domain protein, DegV family
AVL59_RS40160	COG0495	leucyl-tRNA aminoacylation
AVL59_RS40170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AVL59_RS40190	COG0477	Major facilitator Superfamily
AVL59_RS40205	COG0588	phosphoglycerate mutase activity
AVL59_RS40220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVL59_RS40225	COG0501	Belongs to the peptidase M48B family
AVL59_RS40240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVL59_RS40250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVL59_RS40260	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS40275	COG3540	Alkaline phosphatase
AVL59_RS40280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVL59_RS40285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVL59_RS40290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVL59_RS40295	COG1530	ribonuclease E activity
AVL59_RS40305	COG3152	Membrane
AVL59_RS40335	COG4585	Histidine kinase
AVL59_RS40340	COG2197	response regulator
AVL59_RS40345	COG1846	Transcriptional regulator
AVL59_RS40350	COG1902	pentaerythritol trinitrate reductase activity
AVL59_RS40355	COG0604	alcohol dehydrogenase
AVL59_RS40375	COG2124	cytochrome p450
AVL59_RS40380	COG2770	Histidine kinase
AVL59_RS40380	COG2208	phosphoserine phosphatase activity
AVL59_RS40415	COG0076	glutamate decarboxylase activity
AVL59_RS40425	COG0789	Transcriptional regulator
AVL59_RS40475	COG0772	Belongs to the SEDS family
AVL59_RS40480	COG0768	penicillin binding
AVL59_RS40495	COG1077	Cell shape determining protein MreB Mrl
AVL59_RS40500	COG0105	UTP biosynthetic process
AVL59_RS40510	COG0285	dihydrofolate synthase activity
AVL59_RS40515	COG0525	valine-tRNA ligase activity
AVL59_RS40525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVL59_RS40530	COG0740	serine-type endopeptidase activity
AVL59_RS40535	COG0740	serine-type endopeptidase activity
AVL59_RS40540	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVL59_RS40555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS40555	COG0515	serine threonine protein kinase
AVL59_RS40565	COG3594	Acyltransferase
AVL59_RS40580	COG1136	(ABC) transporter
AVL59_RS40590	COG4552	Acetyltransferase involved in intracellular survival and related
AVL59_RS40605	COG1113	amino acid transport
AVL59_RS40610	COG0515	serine threonine protein kinase
AVL59_RS40625	COG1940	carbohydrate kinase activity
AVL59_RS40630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVL59_RS40635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVL59_RS40640	COG1116	anion transmembrane transporter activity
AVL59_RS40645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS40655	COG1113	amino acid transport
AVL59_RS40660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVL59_RS40665	COG2409	Drug exporters of the RND superfamily
AVL59_RS40670	COG4585	Histidine kinase
AVL59_RS40675	COG2197	response regulator
AVL59_RS40680	COG0588	phosphoglycerate mutase activity
AVL59_RS40685	COG1070	Carbohydrate kinase
AVL59_RS40690	COG1349	DNA-binding transcription factor activity
AVL59_RS40710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AVL59_RS40725	COG2318	DinB family
AVL59_RS40730	COG2755	lipolytic protein G-D-S-L family
AVL59_RS40805	COG0583	DNA-binding transcription factor activity
AVL59_RS40820	COG0697	spore germination
AVL59_RS40855	COG1136	(ABC) transporter
AVL59_RS40870	COG0668	transmembrane transport
AVL59_RS40875	COG1940	carbohydrate kinase activity
AVL59_RS40880	COG1653	transport
AVL59_RS40885	COG1175	transmembrane transport
AVL59_RS40890	COG0395	ABC-type sugar transport system, permease component
AVL59_RS40895	COG1486	melibiose metabolic process
AVL59_RS40915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL59_RS40970	COG1136	(ABC) transporter
AVL59_RS41035	COG1609	Transcriptional regulator
AVL59_RS41100	COG0629	single-stranded DNA binding
AVL59_RS41165	COG2304	oxidoreductase activity
AVL59_RS41185	COG1022	Amp-dependent synthetase and ligase
AVL59_RS41210	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS41220	COG0728	peptidoglycan biosynthetic process
AVL59_RS41235	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS41285	COG3962	Belongs to the TPP enzyme family
AVL59_RS41290	COG3718	enzyme involved in inositol metabolism
AVL59_RS41300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL59_RS41320	COG2409	Drug exporters of the RND superfamily
AVL59_RS41350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVL59_RS41365	COG1129	ABC transporter
AVL59_RS41375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVL59_RS41380	COG1869	D-ribose catabolic process
AVL59_RS41400	COG0673	inositol 2-dehydrogenase activity
AVL59_RS41410	COG0456	acetyltransferase
AVL59_RS41410	COG1846	Transcriptional regulator
AVL59_RS41430	COG1472	Belongs to the glycosyl hydrolase 3 family
AVL59_RS41465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVL59_RS41495	COG0028	Belongs to the TPP enzyme family
AVL59_RS41505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL59_RS41525	COG1946	Acyl-CoA thioesterase
AVL59_RS41535	COG1309	transcriptional regulator
AVL59_RS41540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL59_RS41555	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS41585	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AVL59_RS41620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVL59_RS41630	COG0589	response to stress
AVL59_RS41640	COG4977	sequence-specific DNA binding
AVL59_RS41645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AVL59_RS41655	COG0477	Major facilitator Superfamily
AVL59_RS41695	COG3979	chitinase
AVL59_RS41705	COG4221	oxidoreductase activity
AVL59_RS41715	COG0745	RESPONSE REGULATOR receiver
AVL59_RS41740	COG0406	alpha-ribazole phosphatase activity
AVL59_RS41790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVL59_RS41805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVL59_RS41810	COG0154	amidase activity
AVL59_RS41820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVL59_RS41825	COG0765	amino acid transport
AVL59_RS41830	COG0765	amino acid transport
AVL59_RS41835	COG1126	abc transporter atp-binding protein
AVL59_RS41855	COG3397	chitin binding
AVL59_RS41875	COG2186	Transcriptional regulator
AVL59_RS41940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVL59_RS41945	COG2188	Transcriptional regulator
AVL59_RS41965	COG0673	inositol 2-dehydrogenase activity
AVL59_RS41970	COG4702	Belongs to the UPF0303 family
AVL59_RS41985	COG0667	Aldo Keto reductase
AVL59_RS42030	COG3764	Sortase (surface protein transpeptidase)
AVL59_RS42040	COG0701	Predicted permease
AVL59_RS42105	COG0535	radical SAM domain protein
AVL59_RS42175	COG2733	membrane
AVL59_RS42180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AVL59_RS42220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL59_RS42235	COG4555	ABC transporter
AVL59_RS42250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AVL59_RS42255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVL59_RS42260	COG1263	PTS System
AVL59_RS42265	COG1263	PTS System
AVL59_RS42305	COG1113	amino acid transport
AVL59_RS42315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVL59_RS42325	COG1335	isochorismatase
AVL59_RS42345	COG1714	RDD family
AVL59_RS42360	COG0277	FAD linked oxidase domain protein
AVL59_RS42370	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AVL59_RS42380	COG3480	Lon protease (S16) C-terminal proteolytic domain
AVL59_RS42385	COG4948	Mandelate Racemase Muconate Lactonizing
AVL59_RS42400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVL59_RS42450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AVL59_RS42455	COG0395	ABC-type sugar transport system, permease component
AVL59_RS42460	COG1175	transmembrane transport
AVL59_RS42475	COG1678	Uncharacterized ACR, COG1678
AVL59_RS42480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVL59_RS42485	COG0776	regulation of translation
AVL59_RS42495	COG3973	AAA domain
AVL59_RS42540	COG2223	nitrite transmembrane transporter activity
AVL59_RS42570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVL59_RS42575	COG0793	Belongs to the peptidase S41A family
AVL59_RS42580	COG2177	Part of the ABC transporter FtsEX involved in
AVL59_RS42585	COG2884	Cell division ATP-binding protein ftsE
AVL59_RS42600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AVL59_RS42605	COG0515	serine threonine protein kinase
AVL59_RS42610	COG0515	serine threonine protein kinase
AVL59_RS42615	COG1674	ftsk spoiiie
AVL59_RS42625	COG1175	transmembrane transport
AVL59_RS42630	COG0395	ABC-type sugar transport system, permease component
AVL59_RS42635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVL59_RS42635	COG0463	Glycosyl transferase, family 2
AVL59_RS42640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVL59_RS42645	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS42650	COG1764	response to oxidative stress
AVL59_RS42655	COG1846	Transcriptional regulator
AVL59_RS42670	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS42695	COG1388	LysM domain
AVL59_RS42695	COG1134	teichoic acid transport
AVL59_RS42700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVL59_RS42705	COG1215	transferase activity, transferring glycosyl groups
AVL59_RS42710	COG3547	Transposase (IS116 IS110 IS902 family)
AVL59_RS42725	COG2902	Dehydrogenase
AVL59_RS42750	COG0653	protein targeting
AVL59_RS42760	COG3214	Protein conserved in bacteria
AVL59_RS42765	COG2197	response regulator
AVL59_RS42770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AVL59_RS42780	COG0823	Involved in the tonB-independent uptake of proteins
AVL59_RS42785	COG5002	protein histidine kinase activity
AVL59_RS42785	COG5000	phosphorelay sensor kinase activity
AVL59_RS42790	COG0745	RESPONSE REGULATOR receiver
AVL59_RS42795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AVL59_RS42815	COG0714	Associated with various cellular activities
AVL59_RS42855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AVL59_RS42860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVL59_RS42860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVL59_RS42860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVL59_RS42870	COG1482	cell wall glycoprotein biosynthetic process
AVL59_RS42920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AVL59_RS42925	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AVL59_RS42925	COG0778	Nitroreductase
AVL59_RS42950	COG1316	TRANSCRIPTIONal
AVL59_RS42955	COG1316	TRANSCRIPTIONal
AVL59_RS42960	COG1316	TRANSCRIPTIONal
AVL59_RS42975	COG1316	TRANSCRIPTIONal
AVL59_RS42985	COG1316	TRANSCRIPTIONal
AVL59_RS43000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AVL59_RS43020	COG1902	pentaerythritol trinitrate reductase activity
AVL59_RS43045	COG2205	protein histidine kinase activity
AVL59_RS43050	COG0745	RESPONSE REGULATOR receiver
AVL59_RS43055	COG3104	oligopeptide transport
AVL59_RS43090	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS43095	COG1191	sigma factor activity
AVL59_RS43105	COG1228	amidohydrolase
AVL59_RS43115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVL59_RS43120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AVL59_RS43160	COG2986	histidine ammonia-lyase
AVL59_RS43170	COG0659	secondary active sulfate transmembrane transporter activity
AVL59_RS43180	COG4221	oxidoreductase activity
AVL59_RS43195	COG2755	lipolytic protein G-D-S-L family
AVL59_RS43200	COG0183	Belongs to the thiolase family
AVL59_RS43235	COG1136	(ABC) transporter
AVL59_RS43240	COG0577	efflux transmembrane transporter activity
AVL59_RS43245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AVL59_RS43250	COG1252	NADH dehydrogenase
AVL59_RS43265	COG0148	phosphopyruvate hydratase activity
AVL59_RS43275	COG1652	LysM domain
AVL59_RS43345	COG0789	Transcriptional regulator
AVL59_RS43355	COG0577	efflux transmembrane transporter activity
AVL59_RS43360	COG1136	(ABC) transporter
AVL59_RS43365	COG0477	Major facilitator Superfamily
AVL59_RS43375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVL59_RS43410	COG4585	Histidine kinase
AVL59_RS43425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVL59_RS43430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVL59_RS43435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVL59_RS43440	COG0193	aminoacyl-tRNA hydrolase activity
AVL59_RS43460	COG1309	transcriptional regulator
AVL59_RS43475	COG4106	trans-aconitate 2-methyltransferase activity
AVL59_RS43485	COG2197	response regulator
AVL59_RS43500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AVL59_RS43540	COG0488	(ABC) transporter
AVL59_RS43550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVL59_RS43555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVL59_RS43565	COG0084	hydrolase, TatD family'
AVL59_RS43610	COG0310	cobalt ion transport
AVL59_RS43620	COG1122	ATPase activity
AVL59_RS43635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVL59_RS43670	COG2409	Drug exporters of the RND superfamily
AVL59_RS43680	COG0793	Belongs to the peptidase S41A family
AVL59_RS43680	COG4946	Tricorn protease homolog
AVL59_RS43690	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS43695	COG2267	carboxylic ester hydrolase activity
AVL59_RS43700	COG2072	flavoprotein involved in K transport
AVL59_RS43755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVL59_RS43760	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVL59_RS43760	COG0315	cyclic pyranopterin monophosphate synthase activity
AVL59_RS43765	COG0315	cyclic pyranopterin monophosphate synthase activity
AVL59_RS43775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVL59_RS43780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVL59_RS43805	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AVL59_RS43815	COG1970	mechanosensitive ion channel activity
AVL59_RS43830	COG3191	aminopeptidase activity
AVL59_RS43850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVL59_RS43850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVL59_RS43850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVL59_RS43855	COG1105	Belongs to the carbohydrate kinase PfkB family
AVL59_RS43860	COG1349	DNA-binding transcription factor activity
AVL59_RS43865	COG0477	Major facilitator Superfamily
AVL59_RS43870	COG2378	regulation of single-species biofilm formation
AVL59_RS43885	COG1247	-acetyltransferase
AVL59_RS43890	COG3384	dioxygenase
AVL59_RS43895	COG1846	Transcriptional regulator
AVL59_RS43915	COG1414	Transcriptional regulator
AVL59_RS43980	COG1695	Transcriptional regulator
AVL59_RS44020	COG4942	peptidase
AVL59_RS44025	COG0330	HflC and HflK could
AVL59_RS44040	COG0386	Belongs to the glutathione peroxidase family
AVL59_RS44060	COG1686	Belongs to the peptidase S11 family
AVL59_RS44125	COG3629	intracellular signal transduction
AVL59_RS44125	COG3903	Transcriptional regulator
AVL59_RS44175	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVL59_RS44200	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AVL59_RS44235	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AVL59_RS44310	COG1024	Enoyl-CoA hydratase
AVL59_RS44315	COG0515	serine threonine protein kinase
AVL59_RS44315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVL59_RS44325	COG1309	transcriptional regulator
AVL59_RS44330	COG1522	sequence-specific DNA binding
AVL59_RS44335	COG1280	lysine exporter protein (LysE YggA)
AVL59_RS44345	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS44360	COG0259	pyridoxamine-phosphate oxidase activity
AVL59_RS44380	COG2072	flavoprotein involved in K transport
AVL59_RS44390	COG1024	Enoyl-CoA hydratase
AVL59_RS44405	COG2814	Major facilitator Superfamily
AVL59_RS44415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVL59_RS44420	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS44425	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS44440	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS44445	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS44455	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS44465	COG1595	DNA-templated transcription, initiation
AVL59_RS44480	COG1366	Belongs to the anti-sigma-factor antagonist family
AVL59_RS44535	COG2945	thiolester hydrolase activity
AVL59_RS44535	COG0596	Alpha beta hydrolase
AVL59_RS44545	COG4821	SIS domain
AVL59_RS44555	COG0259	pyridoxamine-phosphate oxidase activity
AVL59_RS44570	COG1309	transcriptional regulator
AVL59_RS44580	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS44595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AVL59_RS44610	COG0281	malic enzyme
AVL59_RS44630	COG5006	permease, DMT superfamily
AVL59_RS44635	COG1132	(ABC) transporter
AVL59_RS44650	COG0247	lactate metabolic process
AVL59_RS44650	COG0277	FAD linked oxidase domain protein
AVL59_RS44655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AVL59_RS44675	COG0667	Aldo Keto reductase
AVL59_RS44705	COG2252	PERMEase
AVL59_RS44715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVL59_RS44740	COG2814	Major facilitator Superfamily
AVL59_RS44750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVL59_RS44755	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AVL59_RS44760	COG1278	Cold shock
AVL59_RS44790	COG1061	Type III restriction enzyme res subunit
AVL59_RS44805	COG3973	AAA domain
AVL59_RS44810	COG3142	Participates in the control of copper homeostasis
AVL59_RS44850	COG1737	Transcriptional regulator
AVL59_RS44855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AVL59_RS44860	COG1263	PTS System
AVL59_RS44860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVL59_RS44920	COG0459	protein refolding
AVL59_RS44940	COG0463	Glycosyl transferase, family 2
AVL59_RS44945	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AVL59_RS44955	COG1280	lysine exporter protein (LysE YggA)
AVL59_RS44960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS44990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVL59_RS44995	COG0460	homoserine dehydrogenase
AVL59_RS45010	COG1940	carbohydrate kinase activity
AVL59_RS45030	COG3300	MHYT domain
AVL59_RS45030	COG5001	Diguanylate cyclase
AVL59_RS45095	COG0110	maltose O-acetyltransferase activity
AVL59_RS45175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS45180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS45190	COG0662	Cupin 2, conserved barrel domain protein
AVL59_RS45195	COG2329	Antibiotic biosynthesis monooxygenase
AVL59_RS45210	COG3842	ATPase activity
AVL59_RS45235	COG0215	cysteine-tRNA ligase activity
AVL59_RS45240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVL59_RS45245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVL59_RS45250	COG1329	Transcriptional regulator
AVL59_RS45265	COG5002	protein histidine kinase activity
AVL59_RS45315	COG0588	phosphoglycerate mutase activity
AVL59_RS45360	COG0438	transferase activity, transferring glycosyl groups
AVL59_RS45405	COG1309	transcriptional regulator
AVL59_RS45415	COG4552	Acetyltransferase involved in intracellular survival and related
AVL59_RS45425	COG1490	D-aminoacyl-tRNA deacylase activity
AVL59_RS45430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVL59_RS45435	COG0735	belongs to the Fur family
AVL59_RS45440	COG3485	protocatechuate 3,4-dioxygenase
AVL59_RS45490	COG0745	RESPONSE REGULATOR receiver
AVL59_RS45495	COG1609	Transcriptional regulator
AVL59_RS45500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL59_RS45565	COG0456	acetyltransferase
AVL59_RS45570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVL59_RS45580	COG0494	nUDIX hydrolase
AVL59_RS45580	COG0406	alpha-ribazole phosphatase activity
AVL59_RS45590	COG1937	Protein conserved in bacteria
AVL59_RS45600	COG0306	phosphate transporter
AVL59_RS45610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVL59_RS45630	COG0277	FAD linked oxidase domain protein
AVL59_RS45640	COG0671	phosphoesterase, PA-phosphatase related
AVL59_RS45675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVL59_RS45680	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS45770	COG1252	NADH dehydrogenase
AVL59_RS45795	COG0579	oxidoreductase
AVL59_RS45800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVL59_RS45810	COG0667	Aldo Keto reductase
AVL59_RS45825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVL59_RS45825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVL59_RS45835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVL59_RS45850	COG2197	response regulator
AVL59_RS45855	COG4585	Histidine kinase
AVL59_RS45875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVL59_RS45895	COG0640	Transcriptional regulator
AVL59_RS45900	COG2226	methyltransferase
AVL59_RS45920	COG0513	Belongs to the DEAD box helicase family
AVL59_RS46010	COG2197	response regulator
AVL59_RS46015	COG2197	response regulator
AVL59_RS46020	COG4585	Histidine kinase
AVL59_RS46030	COG1131	(ABC) transporter
AVL59_RS46040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVL59_RS46080	COG1819	glycosyl
AVL59_RS46095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVL59_RS46115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVL59_RS46130	COG3629	intracellular signal transduction
AVL59_RS46145	COG1819	glycosyl
AVL59_RS46190	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS46195	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AVL59_RS46205	COG1028	Short-chain dehydrogenase reductase Sdr
AVL59_RS46245	COG1643	Atp-dependent helicase
AVL59_RS46280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVL59_RS46310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVL59_RS46315	COG0047	phosphoribosylformylglycinamidine synthase activity
AVL59_RS46320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVL59_RS46355	COG2197	response regulator
AVL59_RS46365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVL59_RS46380	COG0151	Belongs to the GarS family
AVL59_RS46410	COG0142	geranyltranstransferase activity
AVL59_RS46455	COG2372	response to copper ion
AVL59_RS46455	COG1276	copper resistance
AVL59_RS46505	COG0433	COG0433 Predicted ATPase
AVL59_RS46520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVL59_RS46555	COG1191	sigma factor activity
AVL59_RS46560	COG1191	sigma factor activity
AVL59_RS46580	COG0477	Major facilitator Superfamily
AVL59_RS46585	COG2353	YceI-like domain
AVL59_RS46590	COG3467	pyridoxamine 5'-phosphate
AVL59_RS46600	COG0477	Major facilitator Superfamily
AVL59_RS46605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVL59_RS46615	COG2205	protein histidine kinase activity
AVL59_RS46620	COG0745	RESPONSE REGULATOR receiver
AVL59_RS46625	COG2329	Antibiotic biosynthesis monooxygenase
AVL59_RS46640	COG1846	Transcriptional regulator
AVL59_RS46675	COG0202	RNA polymerase activity
AVL59_RS46700	COG1309	transcriptional regulator
AVL59_RS46705	COG2814	Major facilitator Superfamily
AVL59_RS46710	COG0318	PFAM AMP-dependent synthetase and ligase
AVL59_RS46715	COG1595	DNA-templated transcription, initiation
AVL59_RS46740	COG1960	acyl-CoA dehydrogenase activity
AVL59_RS46770	COG2188	Transcriptional regulator
AVL59_RS46790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVL59_RS46805	COG0653	protein targeting
AVL59_RS46825	COG0006	proline dipeptidase activity
AVL59_RS46830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVL59_RS46870	COG2837	iron assimilation
AVL59_RS46875	COG0077	Prephenate dehydratase
AVL59_RS46880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVL59_RS46885	COG0561	phosphatase activity
AVL59_RS46915	COG1131	(ABC) transporter
AVL59_RS46930	COG0789	Transcriptional regulator
AVL59_RS46935	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AVL59_RS46950	COG0561	phosphatase activity
AVL59_RS46955	COG4988	ABC transporter
AVL59_RS46960	COG1294	oxidase, subunit
AVL59_RS46965	COG1271	oxidase subunit
AVL59_RS46975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVL59_RS46980	COG1609	Transcriptional regulator
AVL59_RS46995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVL59_RS47020	COG0662	Cupin 2, conserved barrel domain protein
AVL59_RS47025	COG1950	PFAM Membrane protein of
AVL59_RS47030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVL59_RS47035	COG0626	cystathionine gamma-synthase activity
AVL59_RS47070	COG2814	Major facilitator Superfamily
AVL59_RS47095	COG0305	Participates in initiation and elongation during chromosome replication
AVL59_RS47105	COG0359	binds to the 23S rRNA
AVL59_RS47110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVL59_RS47115	COG0629	single-stranded DNA binding
AVL59_RS47120	COG0360	Binds together with S18 to 16S ribosomal RNA
AVL59_RS47145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVL59_RS47165	COG0617	tRNA 3'-terminal CCA addition
AVL59_RS47180	COG2815	serine threonine protein kinase
AVL59_RS47180	COG0515	serine threonine protein kinase
AVL59_RS47195	COG0492	ferredoxin-NADP+ reductase activity
AVL59_RS47200	COG3118	belongs to the thioredoxin family
AVL59_RS47215	COG1192	Involved in chromosome partitioning
AVL59_RS47220	COG0357	Ribosomal RNA small subunit methyltransferase G
AVL59_RS47230	COG0706	membrane insertase activity
AVL59_RS47235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane