locus-tag	class	description
HEP81_RS00060	COG2124	cytochrome p450
HEP81_RS00065	COG1024	Enoyl-CoA hydratase
HEP81_RS00075	COG1119	ATPase activity
HEP81_RS00080	COG0142	geranyltranstransferase activity
HEP81_RS00090	COG0784	Response regulator, receiver
HEP81_RS00100	COG4251	negative regulation of phosphorylation
HEP81_RS00120	COG0583	DNA-binding transcription factor activity
HEP81_RS00135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP81_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS00225	COG2271	Major facilitator Superfamily
HEP81_RS00230	COG0477	Major facilitator Superfamily
HEP81_RS00235	COG2124	cytochrome p450
HEP81_RS00250	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS00440	COG2801	Transposase and inactivated derivatives
HEP81_RS00485	COG1309	transcriptional regulator
HEP81_RS00510	COG1733	regulation of RNA biosynthetic process
HEP81_RS00515	COG0702	epimerase
HEP81_RS00570	COG0745	RESPONSE REGULATOR receiver
HEP81_RS00600	COG1278	Cold shock
HEP81_RS00700	COG2197	response regulator
HEP81_RS00715	COG0107	imidazoleglycerol-phosphate synthase activity
HEP81_RS00720	COG1063	alcohol dehydrogenase
HEP81_RS00735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP81_RS00855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP81_RS00880	COG1309	transcriptional regulator
HEP81_RS00890	COG0667	Aldo Keto reductase
HEP81_RS00895	COG3321	synthase
HEP81_RS00895	COG0604	alcohol dehydrogenase
HEP81_RS00940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEP81_RS01045	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP81_RS01075	COG0561	phosphatase activity
HEP81_RS01100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HEP81_RS01105	COG3845	ABC transporter
HEP81_RS01110	COG1122	ATPase activity
HEP81_RS01125	COG0667	Aldo Keto reductase
HEP81_RS01140	COG0657	acetylesterase activity
HEP81_RS01150	COG3655	Transcriptional regulator
HEP81_RS01175	COG1136	(ABC) transporter
HEP81_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS01195	COG1309	transcriptional regulator
HEP81_RS01220	COG2207	Transcriptional regulator
HEP81_RS01235	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP81_RS01235	COG2319	Wd-40 repeat
HEP81_RS01250	COG3479	Phenolic acid decarboxylase
HEP81_RS01290	COG1595	DNA-templated transcription, initiation
HEP81_RS01325	COG2124	cytochrome p450
HEP81_RS01330	COG1846	Transcriptional regulator
HEP81_RS01345	COG1819	glycosyl
HEP81_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS01385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS01395	COG0431	NADPH-dependent FMN reductase
HEP81_RS01410	COG0583	DNA-binding transcription factor activity
HEP81_RS01455	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP81_RS01465	COG1175	transmembrane transport
HEP81_RS01470	COG0395	ABC-type sugar transport system, permease component
HEP81_RS01505	COG2353	YceI-like domain
HEP81_RS01510	COG2353	YceI-like domain
HEP81_RS01520	COG2267	carboxylic ester hydrolase activity
HEP81_RS01555	COG3938	Belongs to the proline racemase family
HEP81_RS01560	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS01590	COG3291	Pkd domain containing protein
HEP81_RS01595	COG0006	proline dipeptidase activity
HEP81_RS01655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP81_RS01660	COG3483	tryptophan 2,3-dioxygenase activity
HEP81_RS01685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP81_RS01685	COG0515	serine threonine protein kinase
HEP81_RS01690	COG2135	peptidase activity
HEP81_RS01730	COG2197	response regulator
HEP81_RS01735	COG4585	Histidine kinase
HEP81_RS01760	COG2205	protein histidine kinase activity
HEP81_RS01780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP81_RS01790	COG0019	diaminopimelate decarboxylase activity
HEP81_RS01795	COG4264	IucA IucC family
HEP81_RS01805	COG0745	RESPONSE REGULATOR receiver
HEP81_RS01810	COG2205	protein histidine kinase activity
HEP81_RS01865	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP81_RS01870	COG1129	ABC transporter
HEP81_RS01880	COG2160	L-arabinose isomerase activity
HEP81_RS01895	COG1609	Transcriptional regulator
HEP81_RS01905	COG0515	serine threonine protein kinase
HEP81_RS01905	COG3266	domain, Protein
HEP81_RS01925	COG0151	Belongs to the GarS family
HEP81_RS02090	COG0583	DNA-binding transcription factor activity
HEP81_RS02105	COG2318	DinB family
HEP81_RS02110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HEP81_RS02110	COG5479	isomerase activity
HEP81_RS02130	COG0412	Dienelactone hydrolase
HEP81_RS02150	COG4257	antibiotic catabolic process
HEP81_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS02165	COG0372	Belongs to the citrate synthase family
HEP81_RS02215	COG1595	DNA-templated transcription, initiation
HEP81_RS02220	COG2318	DinB family
HEP81_RS02240	COG5002	protein histidine kinase activity
HEP81_RS02280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP81_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS02300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS02310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP81_RS02315	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HEP81_RS02345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP81_RS02355	COG0673	inositol 2-dehydrogenase activity
HEP81_RS02440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS02455	COG0367	asparagine synthase
HEP81_RS02465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS02470	COG0456	acetyltransferase
HEP81_RS02480	COG1131	(ABC) transporter
HEP81_RS02490	COG3251	PFAM MbtH domain protein
HEP81_RS02520	COG2072	flavoprotein involved in K transport
HEP81_RS02545	COG0445	tRNA wobble uridine modification
HEP81_RS02550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP81_RS02580	COG2706	6-phosphogluconolactonase activity
HEP81_RS02590	COG3387	PFAM Glycoside hydrolase 15-related
HEP81_RS02595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEP81_RS02600	COG3265	gluconokinase activity
HEP81_RS02630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP81_RS02630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP81_RS02640	COG0730	response to heat
HEP81_RS02660	COG5297	Belongs to the glycosyl hydrolase family 6
HEP81_RS02660	COG4733	cellulase activity
HEP81_RS02665	COG5297	Belongs to the glycosyl hydrolase family 6
HEP81_RS02670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP81_RS02685	COG0477	Major facilitator Superfamily
HEP81_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS02725	COG1309	transcriptional regulator
HEP81_RS02750	COG2814	Major facilitator Superfamily
HEP81_RS02765	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS02770	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS02775	COG2172	sigma factor antagonist activity
HEP81_RS02820	COG0248	Ppx GppA phosphatase
HEP81_RS02845	COG3469	chitinase activity
HEP81_RS02855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HEP81_RS02865	COG2814	Major facilitator Superfamily
HEP81_RS02915	COG2197	response regulator
HEP81_RS02920	COG4585	Histidine kinase
HEP81_RS02975	COG2045	Belongs to the ComB family
HEP81_RS02990	COG2172	sigma factor antagonist activity
HEP81_RS02990	COG2208	phosphoserine phosphatase activity
HEP81_RS02990	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS02995	COG0590	tRNA wobble adenosine to inosine editing
HEP81_RS03010	COG0583	DNA-binding transcription factor activity
HEP81_RS03015	COG3387	PFAM Glycoside hydrolase 15-related
HEP81_RS03030	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEP81_RS03045	COG0586	Pfam SNARE associated Golgi protein
HEP81_RS03050	COG0671	phosphoesterase, PA-phosphatase related
HEP81_RS03060	COG2814	Major facilitator Superfamily
HEP81_RS03065	COG1335	isochorismatase
HEP81_RS03080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP81_RS03110	COG0572	uridine kinase
HEP81_RS03155	COG1309	transcriptional regulator
HEP81_RS03175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEP81_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS03245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP81_RS03290	COG0300	oxidoreductase activity
HEP81_RS03295	COG4948	Mandelate Racemase Muconate Lactonizing
HEP81_RS03300	COG0247	lactate metabolic process
HEP81_RS03300	COG0277	FAD linked oxidase domain protein
HEP81_RS03350	COG2274	protein secretion by the type I secretion system
HEP81_RS03375	COG4221	oxidoreductase activity
HEP81_RS03395	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP81_RS03410	COG0596	Alpha beta hydrolase
HEP81_RS03440	COG0583	DNA-binding transcription factor activity
HEP81_RS03445	COG2814	Major facilitator Superfamily
HEP81_RS03460	COG1733	regulation of RNA biosynthetic process
HEP81_RS03525	COG0667	Aldo Keto reductase
HEP81_RS03550	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HEP81_RS03555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS03560	COG3629	intracellular signal transduction
HEP81_RS03570	COG0657	acetylesterase activity
HEP81_RS03605	COG2124	cytochrome p450
HEP81_RS03625	COG0435	Glutathione S-transferase
HEP81_RS03655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP81_RS03660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP81_RS03665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS03705	COG1796	DNA polymerase
HEP81_RS03705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEP81_RS03755	COG2706	6-phosphogluconolactonase activity
HEP81_RS03765	COG1309	transcriptional regulator
HEP81_RS03775	COG1357	PFAM Pentapeptide repeats (8 copies)
HEP81_RS03795	COG0247	lactate metabolic process
HEP81_RS03800	COG1139	Iron-sulfur cluster binding protein
HEP81_RS03805	COG1556	Lactate utilization protein
HEP81_RS03825	COG1174	glycine betaine transport
HEP81_RS03830	COG0542	response to heat
HEP81_RS03850	COG1191	sigma factor activity
HEP81_RS03930	COG1090	epimerase
HEP81_RS03945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP81_RS03955	COG0640	Transcriptional regulator
HEP81_RS03975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP81_RS03975	COG0515	serine threonine protein kinase
HEP81_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS04000	COG1609	Transcriptional regulator
HEP81_RS04015	COG0726	polysaccharide deacetylase
HEP81_RS04020	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HEP81_RS04025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP81_RS04045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS04050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP81_RS04055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS04065	COG3251	PFAM MbtH domain protein
HEP81_RS04075	COG3340	Belongs to the peptidase S51 family
HEP81_RS04085	COG2197	response regulator
HEP81_RS04110	COG2124	cytochrome p450
HEP81_RS04155	COG0326	Molecular chaperone. Has ATPase activity
HEP81_RS04160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP81_RS04165	COG1993	acr, cog1993
HEP81_RS04170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP81_RS04200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEP81_RS04205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP81_RS04205	COG3608	succinylglutamate desuccinylase aspartoacylase
HEP81_RS04225	COG3608	succinylglutamate desuccinylase aspartoacylase
HEP81_RS04225	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP81_RS04235	COG0242	peptide deformylase activity
HEP81_RS04245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP81_RS04305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP81_RS04310	COG0121	glutamine amidotransferase
HEP81_RS04315	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEP81_RS04320	COG2182	Extracellular solute-binding protein
HEP81_RS04325	COG3360	Dodecin
HEP81_RS04335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS04365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEP81_RS04370	COG1053	succinate dehydrogenase
HEP81_RS04380	COG0583	DNA-binding transcription factor activity
HEP81_RS04420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP81_RS04420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP81_RS04440	COG0531	amino acid
HEP81_RS04455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP81_RS04515	COG3537	Alpha-1,2-mannosidase
HEP81_RS04535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEP81_RS04540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEP81_RS04575	COG0667	Aldo Keto reductase
HEP81_RS04600	COG0601	transmembrane transport
HEP81_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS04645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEP81_RS04645	COG2308	Evidence 4 Homologs of previously reported genes of
HEP81_RS04700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEP81_RS04720	COG1278	Cold shock
HEP81_RS04725	COG0513	Belongs to the DEAD box helicase family
HEP81_RS04765	COG0235	Class ii aldolase
HEP81_RS04765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP81_RS04770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP81_RS04775	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP81_RS04780	COG2801	Transposase and inactivated derivatives
HEP81_RS04780	COG3415	Transposase
HEP81_RS04830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS04830	COG3321	synthase
HEP81_RS04830	COG4221	oxidoreductase activity
HEP81_RS04840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP81_RS04860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP81_RS04870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEP81_RS04885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HEP81_RS04890	COG2079	MmgE PrpD family protein
HEP81_RS04925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HEP81_RS04990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP81_RS04995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP81_RS05000	COG2080	2 iron, 2 sulfur cluster binding
HEP81_RS05005	COG1132	(ABC) transporter
HEP81_RS05015	COG1024	Enoyl-CoA hydratase
HEP81_RS05045	COG0531	amino acid
HEP81_RS05050	COG0668	transmembrane transport
HEP81_RS05060	COG2838	Isocitrate dehydrogenase
HEP81_RS05075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP81_RS05090	COG2124	cytochrome p450
HEP81_RS05145	COG2267	carboxylic ester hydrolase activity
HEP81_RS05200	COG2197	response regulator
HEP81_RS05210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS05215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS05225	COG1126	abc transporter atp-binding protein
HEP81_RS05245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP81_RS05250	COG0531	amino acid
HEP81_RS05260	COG0702	epimerase
HEP81_RS05265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP81_RS05270	COG2197	response regulator
HEP81_RS05275	COG4585	Histidine kinase
HEP81_RS05285	COG1136	(ABC) transporter
HEP81_RS05285	COG0577	efflux transmembrane transporter activity
HEP81_RS05290	COG3275	phosphorelay sensor kinase activity
HEP81_RS05305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP81_RS05310	COG1584	GPR1 FUN34 yaaH family protein
HEP81_RS05315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP81_RS05320	COG0154	amidase activity
HEP81_RS05350	COG0673	inositol 2-dehydrogenase activity
HEP81_RS05355	COG0673	inositol 2-dehydrogenase activity
HEP81_RS05385	COG2124	cytochrome p450
HEP81_RS05410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP81_RS05450	COG0667	Aldo Keto reductase
HEP81_RS05460	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS05465	COG0183	Belongs to the thiolase family
HEP81_RS05470	COG2267	carboxylic ester hydrolase activity
HEP81_RS05490	COG0561	phosphatase activity
HEP81_RS05500	COG0174	glutamine synthetase
HEP81_RS05525	COG3903	Transcriptional regulator
HEP81_RS05525	COG3629	intracellular signal transduction
HEP81_RS05555	COG3903	Transcriptional regulator
HEP81_RS05555	COG3629	intracellular signal transduction
HEP81_RS05580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HEP81_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS05610	COG3959	Transketolase, thiamine diphosphate binding domain
HEP81_RS05615	COG3958	Transketolase
HEP81_RS05630	COG0583	DNA-binding transcription factor activity
HEP81_RS05635	COG0156	8-amino-7-oxononanoate synthase activity
HEP81_RS05640	COG1063	alcohol dehydrogenase
HEP81_RS05695	COG1473	amidohydrolase
HEP81_RS05710	COG0842	Transport permease protein
HEP81_RS05715	COG1131	(ABC) transporter
HEP81_RS05755	COG2755	lipolytic protein G-D-S-L family
HEP81_RS05760	COG2365	Tyrosine phosphatase family
HEP81_RS05780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP81_RS05785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP81_RS05800	COG1657	PFAM Prenyltransferase squalene oxidase
HEP81_RS05810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HEP81_RS05820	COG1562	ergosterol biosynthetic process
HEP81_RS05825	COG1134	teichoic acid transport
HEP81_RS05870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP81_RS05885	COG1024	Enoyl-CoA hydratase
HEP81_RS05900	COG4977	sequence-specific DNA binding
HEP81_RS05905	COG2183	response to ionizing radiation
HEP81_RS05915	COG0488	(ABC) transporter
HEP81_RS05925	COG2936	dipeptidyl-peptidase activity
HEP81_RS05940	COG1113	amino acid transport
HEP81_RS05950	COG1024	Enoyl-CoA hydratase
HEP81_RS05950	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP81_RS05955	COG0183	Belongs to the thiolase family
HEP81_RS05960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS05965	COG3268	Saccharopine dehydrogenase
HEP81_RS05975	COG1515	deoxyribonuclease V activity
HEP81_RS06000	COG0488	(ABC) transporter
HEP81_RS06005	COG1834	amidinotransferase
HEP81_RS06035	COG1793	dna ligase
HEP81_RS06055	COG0477	Major facilitator Superfamily
HEP81_RS06060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP81_RS06090	COG3511	phospholipase C
HEP81_RS06115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEP81_RS06120	COG1486	melibiose metabolic process
HEP81_RS06140	COG0789	Transcriptional regulator
HEP81_RS06145	COG0667	Aldo Keto reductase
HEP81_RS06160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP81_RS06175	COG0166	Belongs to the GPI family
HEP81_RS06180	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP81_RS06185	COG0588	phosphoglycerate mutase activity
HEP81_RS06200	COG2084	Dehydrogenase
HEP81_RS06205	COG3467	pyridoxamine 5'-phosphate
HEP81_RS06240	COG2723	6-phospho-beta-galactosidase activity
HEP81_RS06245	COG0395	ABC-type sugar transport system, permease component
HEP81_RS06250	COG1175	transmembrane transport
HEP81_RS06255	COG2182	Extracellular solute-binding protein
HEP81_RS06290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP81_RS06305	COG4106	trans-aconitate 2-methyltransferase activity
HEP81_RS06330	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HEP81_RS06330	COG0028	Belongs to the TPP enzyme family
HEP81_RS06380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS06385	COG0006	proline dipeptidase activity
HEP81_RS06400	COG0156	8-amino-7-oxononanoate synthase activity
HEP81_RS06410	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HEP81_RS06415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP81_RS06420	COG2423	ornithine cyclodeaminase activity
HEP81_RS06435	COG0569	domain protein
HEP81_RS06435	COG0475	glutathione-regulated potassium exporter activity
HEP81_RS06465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP81_RS06470	COG3251	PFAM MbtH domain protein
HEP81_RS06480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS06545	COG1335	isochorismatase
HEP81_RS06555	COG3537	Alpha-1,2-mannosidase
HEP81_RS06565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP81_RS06570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEP81_RS06575	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS06580	COG1846	Transcriptional regulator
HEP81_RS06610	COG0656	L-ascorbic acid biosynthetic process
HEP81_RS06625	COG4221	oxidoreductase activity
HEP81_RS06640	COG4106	trans-aconitate 2-methyltransferase activity
HEP81_RS06645	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEP81_RS06675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP81_RS06700	COG0028	Belongs to the TPP enzyme family
HEP81_RS06710	COG0693	protein deglycase activity
HEP81_RS06720	COG0488	(ABC) transporter
HEP81_RS06795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP81_RS06800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS06825	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEP81_RS06835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP81_RS06840	COG2362	D-Aminopeptidase
HEP81_RS06845	COG0038	chloride channel
HEP81_RS06860	COG2172	sigma factor antagonist activity
HEP81_RS06860	COG2208	phosphoserine phosphatase activity
HEP81_RS06860	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS06890	COG1295	ribonuclease BN
HEP81_RS06905	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP81_RS06915	COG0604	alcohol dehydrogenase
HEP81_RS06920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS06920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS06925	COG2301	Belongs to the HpcH HpaI aldolase family
HEP81_RS06935	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS06940	COG0688	phosphatidylethanolamine metabolic process
HEP81_RS06950	COG1929	Belongs to the glycerate kinase type-1 family
HEP81_RS06965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP81_RS06975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP81_RS07030	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS07070	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP81_RS07075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP81_RS07080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP81_RS07090	COG0531	amino acid
HEP81_RS07100	COG0095	Lipoate-protein ligase
HEP81_RS07135	COG0542	response to heat
HEP81_RS07200	COG1953	Uracil, thiamine, allantoin
HEP81_RS07210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP81_RS07225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP81_RS07245	COG0542	response to heat
HEP81_RS07250	COG0405	Gamma-glutamyltransferase
HEP81_RS07275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP81_RS07330	COG3387	PFAM Glycoside hydrolase 15-related
HEP81_RS07405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP81_RS07630	COG3547	Transposase (IS116 IS110 IS902 family)
HEP81_RS07715	COG3547	Transposase (IS116 IS110 IS902 family)
HEP81_RS07730	COG0151	Belongs to the GarS family
HEP81_RS07950	COG0714	Associated with various cellular activities
HEP81_RS07970	COG0159	tryptophan synthase activity
HEP81_RS08055	COG1074	ATP-dependent DNA helicase activity
HEP81_RS08110	COG0107	imidazoleglycerol-phosphate synthase activity
HEP81_RS08140	COG0436	Aminotransferase
HEP81_RS08155	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS08160	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS08165	COG1309	transcriptional regulator
HEP81_RS08180	COG2409	Drug exporters of the RND superfamily
HEP81_RS08190	COG1309	transcriptional regulator
HEP81_RS08260	COG1191	sigma factor activity
HEP81_RS08290	COG3293	Transposase
HEP81_RS08315	COG0242	peptide deformylase activity
HEP81_RS08350	COG1725	Transcriptional regulator
HEP81_RS08355	COG1131	(ABC) transporter
HEP81_RS08420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP81_RS08435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS08440	COG0017	Asparaginyl-tRNA synthetase
HEP81_RS08445	COG0069	glutamate synthase activity
HEP81_RS08455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP81_RS08470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP81_RS08480	COG1940	carbohydrate kinase activity
HEP81_RS08500	COG2188	Transcriptional regulator
HEP81_RS08505	COG0673	inositol 2-dehydrogenase activity
HEP81_RS08540	COG4266	Belongs to the allantoicase family
HEP81_RS08545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP81_RS08550	COG1414	Transcriptional regulator
HEP81_RS08570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEP81_RS08580	COG2091	lysine biosynthetic process via aminoadipic acid
HEP81_RS08600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP81_RS08610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS08615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS08625	COG0017	Asparaginyl-tRNA synthetase
HEP81_RS08645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP81_RS08680	COG0384	phenazine biosynthesis protein PhzF
HEP81_RS08695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP81_RS08740	COG1733	regulation of RNA biosynthetic process
HEP81_RS08745	COG0436	Aminotransferase
HEP81_RS08755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP81_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS08765	COG1063	alcohol dehydrogenase
HEP81_RS08780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEP81_RS08785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP81_RS08820	COG0367	asparagine synthase
HEP81_RS08835	COG1454	alcohol dehydrogenase
HEP81_RS08840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP81_RS08865	COG2368	4-hydroxyphenylacetate
HEP81_RS08885	COG4555	ABC transporter
HEP81_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS08920	COG0406	alpha-ribazole phosphatase activity
HEP81_RS08950	COG2233	PERMEase
HEP81_RS08965	COG2351	hydroxyisourate hydrolase activity
HEP81_RS08985	COG3622	Belongs to the hyi family
HEP81_RS08990	COG2084	Dehydrogenase
HEP81_RS08995	COG0753	catalase activity
HEP81_RS09010	COG3960	tartronate-semialdehyde synthase activity
HEP81_RS09020	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS09025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP81_RS09030	COG2197	response regulator
HEP81_RS09045	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEP81_RS09060	COG1653	transport
HEP81_RS09075	COG0515	serine threonine protein kinase
HEP81_RS09085	COG0726	polysaccharide deacetylase
HEP81_RS09105	COG2252	PERMEase
HEP81_RS09110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP81_RS09140	COG1802	Transcriptional regulator
HEP81_RS09155	COG0028	Belongs to the TPP enzyme family
HEP81_RS09175	COG2267	carboxylic ester hydrolase activity
HEP81_RS09185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP81_RS09200	COG1162	GTPase activity
HEP81_RS09210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP81_RS09220	COG0473	3-isopropylmalate dehydrogenase activity
HEP81_RS09220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP81_RS09235	COG0583	DNA-binding transcription factor activity
HEP81_RS09240	COG2814	Major facilitator Superfamily
HEP81_RS09245	COG1942	4-Oxalocrotonate Tautomerase
HEP81_RS09265	COG0277	FAD linked oxidase domain protein
HEP81_RS09285	COG2040	homocysteine
HEP81_RS09300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HEP81_RS09325	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS09340	COG0456	acetyltransferase
HEP81_RS09345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP81_RS09355	COG0175	sulfate reduction
HEP81_RS09360	COG0529	Catalyzes the synthesis of activated sulfate
HEP81_RS09385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEP81_RS09385	COG1116	anion transmembrane transporter activity
HEP81_RS09405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP81_RS09480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP81_RS09555	COG1174	glycine betaine transport
HEP81_RS09565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP81_RS09570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP81_RS09605	COG2326	polyphosphate kinase activity
HEP81_RS09610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP81_RS09610	COG0723	plastoquinol--plastocyanin reductase activity
HEP81_RS09625	COG4152	abc transporter atp-binding protein
HEP81_RS09640	COG3220	belongs to the UPF0276 family
HEP81_RS09655	COG3253	May function as heme-dependent peroxidase
HEP81_RS09665	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP81_RS09675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP81_RS09690	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEP81_RS09695	COG0183	Belongs to the thiolase family
HEP81_RS09700	COG1024	Enoyl-CoA hydratase
HEP81_RS09700	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP81_RS09715	COG0531	amino acid
HEP81_RS09720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP81_RS09725	COG4214	carbohydrate transport
HEP81_RS09735	COG4213	ABC transporter substrate-binding protein
HEP81_RS09740	COG1940	carbohydrate kinase activity
HEP81_RS09745	COG0395	ABC-type sugar transport system, permease component
HEP81_RS09750	COG1175	transmembrane transport
HEP81_RS09755	COG1653	transport
HEP81_RS09805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEP81_RS09810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEP81_RS09825	COG1522	sequence-specific DNA binding
HEP81_RS09830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP81_RS09860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HEP81_RS10015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP81_RS10105	COG4106	trans-aconitate 2-methyltransferase activity
HEP81_RS10130	COG0588	phosphoglycerate mutase activity
HEP81_RS10135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP81_RS10145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP81_RS10170	COG2258	MOSC domain
HEP81_RS10180	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS10215	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP81_RS10220	COG0395	ABC-type sugar transport system, permease component
HEP81_RS10225	COG1175	transmembrane transport
HEP81_RS10230	COG2182	Extracellular solute-binding protein
HEP81_RS10235	COG2188	Transcriptional regulator
HEP81_RS10250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP81_RS10260	COG0477	Major facilitator Superfamily
HEP81_RS10265	COG0477	Major facilitator Superfamily
HEP81_RS10270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP81_RS10285	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS10300	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS10310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP81_RS10335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP81_RS10340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS10345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP81_RS10355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEP81_RS10360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEP81_RS10365	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HEP81_RS10370	COG2814	Major facilitator Superfamily
HEP81_RS10390	COG3629	intracellular signal transduction
HEP81_RS10395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP81_RS10450	COG1024	Enoyl-CoA hydratase
HEP81_RS10460	COG0531	amino acid
HEP81_RS10465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP81_RS10470	COG2235	arginine
HEP81_RS10485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP81_RS10515	COG1799	cell septum assembly
HEP81_RS10560	COG0300	oxidoreductase activity
HEP81_RS10630	COG1846	Transcriptional regulator
HEP81_RS10645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP81_RS10685	COG3903	Transcriptional regulator
HEP81_RS10685	COG3629	intracellular signal transduction
HEP81_RS10725	COG3629	intracellular signal transduction
HEP81_RS10725	COG3903	Transcriptional regulator
HEP81_RS10750	COG3654	unkown
HEP81_RS10760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEP81_RS10765	COG0531	amino acid
HEP81_RS10770	COG0569	domain protein
HEP81_RS10805	COG0756	dUTP diphosphatase activity
HEP81_RS10830	COG2205	protein histidine kinase activity
HEP81_RS10835	COG0745	RESPONSE REGULATOR receiver
HEP81_RS10850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HEP81_RS10885	COG1435	thymidine kinase activity
HEP81_RS10905	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP81_RS10905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP81_RS10905	COG1042	CoA-binding domain protein
HEP81_RS10910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP81_RS10915	COG1802	Transcriptional regulator
HEP81_RS10930	COG0612	Peptidase, M16
HEP81_RS10935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP81_RS10945	COG0372	Belongs to the citrate synthase family
HEP81_RS10950	COG0372	Belongs to the citrate synthase family
HEP81_RS10960	COG3290	protein histidine kinase activity
HEP81_RS10970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP81_RS10980	COG4565	transcriptional regulatory protein
HEP81_RS10985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP81_RS10995	COG2197	response regulator
HEP81_RS11010	COG0187	DNA topoisomerase II activity
HEP81_RS11025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP81_RS11030	COG2186	Transcriptional regulator
HEP81_RS11065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEP81_RS11100	COG0588	phosphoglycerate mutase activity
HEP81_RS11120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP81_RS11125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP81_RS11130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP81_RS11160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP81_RS11170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP81_RS11175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP81_RS11185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEP81_RS11200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP81_RS11205	COG3433	isochorismatase activity
HEP81_RS11205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS11205	COG2226	methyltransferase
HEP81_RS11220	COG1280	lysine exporter protein (LysE YggA)
HEP81_RS11260	COG2205	protein histidine kinase activity
HEP81_RS11265	COG0745	RESPONSE REGULATOR receiver
HEP81_RS11270	COG1126	abc transporter atp-binding protein
HEP81_RS11275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP81_RS11280	COG0765	amino acid transport
HEP81_RS11285	COG0765	amino acid transport
HEP81_RS11300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP81_RS11310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP81_RS11355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP81_RS11360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS11365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP81_RS11390	COG1201	RNA secondary structure unwinding
HEP81_RS11395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP81_RS11405	COG0783	Belongs to the Dps family
HEP81_RS11410	COG1396	sequence-specific DNA binding
HEP81_RS11415	COG1058	Belongs to the CinA family
HEP81_RS11415	COG1546	Belongs to the CinA family
HEP81_RS11425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP81_RS11435	COG1674	ftsk spoiiie
HEP81_RS11445	COG0784	Response regulator, receiver
HEP81_RS11445	COG2205	protein histidine kinase activity
HEP81_RS11450	COG2208	phosphoserine phosphatase activity
HEP81_RS11450	COG2770	Histidine kinase
HEP81_RS11480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEP81_RS11485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP81_RS11490	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HEP81_RS11510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEP81_RS11515	COG0612	Peptidase, M16
HEP81_RS11520	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP81_RS11525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEP81_RS11545	COG1674	ftsk spoiiie
HEP81_RS11575	COG1404	Belongs to the peptidase S8 family
HEP81_RS11595	COG3266	domain, Protein
HEP81_RS11610	COG0455	bacterial-type flagellum organization
HEP81_RS11625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEP81_RS11630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEP81_RS11640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEP81_RS11655	COG0779	Required for maturation of 30S ribosomal subunits
HEP81_RS11685	COG0442	prolyl-tRNA aminoacylation
HEP81_RS11690	COG1247	-acetyltransferase
HEP81_RS11715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP81_RS11720	COG0750	zinc metalloprotease
HEP81_RS11725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP81_RS11780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP81_RS11785	COG1177	transmembrane transport
HEP81_RS11795	COG3842	ATPase activity
HEP81_RS11820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP81_RS11825	COG0584	glycerophosphoryl diester phosphodiesterase
HEP81_RS11835	COG5002	protein histidine kinase activity
HEP81_RS11835	COG0784	Response regulator, receiver
HEP81_RS11835	COG2198	Histidine kinase
HEP81_RS11845	COG2172	sigma factor antagonist activity
HEP81_RS11850	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS11855	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS11875	COG1653	transport
HEP81_RS11880	COG1175	transmembrane transport
HEP81_RS11895	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS11905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP81_RS11910	COG4181	ATPase activity
HEP81_RS11930	COG3842	ATPase activity
HEP81_RS11935	COG4208	sulfate ABC transporter
HEP81_RS11945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP81_RS11955	COG0575	Belongs to the CDS family
HEP81_RS11960	COG0233	cytoplasmic translational termination
HEP81_RS11965	COG0528	UMP kinase activity
HEP81_RS11970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP81_RS11975	COG0052	Belongs to the universal ribosomal protein uS2 family
HEP81_RS11980	COG4942	peptidase
HEP81_RS11990	COG1191	sigma factor activity
HEP81_RS12005	COG0792	nuclease activity
HEP81_RS12025	COG0681	Belongs to the peptidase S26 family
HEP81_RS12040	COG0335	large ribosomal subunit rRNA binding
HEP81_RS12045	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP81_RS12050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP81_RS12055	COG1837	Belongs to the UPF0109 family
HEP81_RS12060	COG0228	four-way junction DNA binding
HEP81_RS12075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP81_RS12085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HEP81_RS12115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP81_RS12130	COG0477	Major facilitator Superfamily
HEP81_RS12145	COG1254	Belongs to the acylphosphatase family
HEP81_RS12160	COG1733	regulation of RNA biosynthetic process
HEP81_RS12165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP81_RS12170	COG0571	ribonuclease III activity
HEP81_RS12175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEP81_RS12190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEP81_RS12195	COG0742	ribosomal rna small subunit methyltransferase
HEP81_RS12205	COG0326	Molecular chaperone. Has ATPase activity
HEP81_RS12215	COG1461	Dihydroxyacetone kinase
HEP81_RS12220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP81_RS12235	COG0351	phosphomethylpyrimidine kinase
HEP81_RS12255	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP81_RS12260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP81_RS12270	COG1920	GTP binding
HEP81_RS12280	COG0776	regulation of translation
HEP81_RS12290	COG0066	3-isopropylmalate dehydratase activity
HEP81_RS12295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEP81_RS12300	COG1414	Transcriptional regulator
HEP81_RS12345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP81_RS12350	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP81_RS12360	COG5002	protein histidine kinase activity
HEP81_RS12365	COG2018	Roadblock/LC7 domain
HEP81_RS12385	COG2018	Roadblock/LC7 domain
HEP81_RS12405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP81_RS12410	COG2353	YceI-like domain
HEP81_RS12450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP81_RS12455	COG0477	Major facilitator Superfamily
HEP81_RS12475	COG2957	Belongs to the agmatine deiminase family
HEP81_RS12480	COG0804	urea catabolic process
HEP81_RS12485	COG0832	Belongs to the urease beta subunit family
HEP81_RS12485	COG0831	urea catabolic process
HEP81_RS12490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP81_RS12495	COG0473	3-isopropylmalate dehydrogenase activity
HEP81_RS12505	COG2130	NADP-dependent
HEP81_RS12510	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS12520	COG3835	regulator
HEP81_RS12530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP81_RS12535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP81_RS12540	COG0440	acetolactate synthase activity
HEP81_RS12550	COG5001	Diguanylate cyclase
HEP81_RS12550	COG3300	MHYT domain
HEP81_RS12560	COG0667	Aldo Keto reductase
HEP81_RS12585	COG2409	Drug exporters of the RND superfamily
HEP81_RS12590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP81_RS12600	COG0154	amidase activity
HEP81_RS12605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP81_RS12625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP81_RS12635	COG4221	oxidoreductase activity
HEP81_RS12640	COG1611	Belongs to the LOG family
HEP81_RS12655	COG0482	sulfurtransferase activity
HEP81_RS12700	COG0583	DNA-binding transcription factor activity
HEP81_RS12720	COG2860	membrane
HEP81_RS12725	COG0308	aminopeptidase N
HEP81_RS12730	COG4608	Belongs to the ABC transporter superfamily
HEP81_RS12740	COG0601	transmembrane transport
HEP81_RS12745	COG0747	negative chemotaxis
HEP81_RS12750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP81_RS12770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP81_RS12775	COG0509	glycine decarboxylation via glycine cleavage system
HEP81_RS12780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP81_RS12785	COG1760	l-serine dehydratase
HEP81_RS12830	COG1024	Enoyl-CoA hydratase
HEP81_RS12840	COG1376	ErfK ybiS ycfS ynhG family protein
HEP81_RS12855	COG1215	transferase activity, transferring glycosyl groups
HEP81_RS12875	COG1132	(ABC) transporter
HEP81_RS12880	COG1132	(ABC) transporter
HEP81_RS12885	COG1131	(ABC) transporter
HEP81_RS12895	COG4585	Histidine kinase
HEP81_RS12900	COG2197	response regulator
HEP81_RS12905	COG1132	(ABC) transporter
HEP81_RS12910	COG1132	(ABC) transporter
HEP81_RS12925	COG0058	SHG alpha-glucan phosphorylase activity
HEP81_RS12930	COG0366	Alpha amylase catalytic
HEP81_RS12940	COG3281	Trehalose synthase
HEP81_RS12945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP81_RS12955	COG3118	belongs to the thioredoxin family
HEP81_RS12970	COG0477	Major facilitator Superfamily
HEP81_RS12980	COG1301	dicarboxylic acid transport
HEP81_RS12985	COG3290	protein histidine kinase activity
HEP81_RS12990	COG4565	transcriptional regulatory protein
HEP81_RS13000	COG1175	transmembrane transport
HEP81_RS13005	COG0395	ABC-type sugar transport system, permease component
HEP81_RS13015	COG0205	6-phosphofructokinase activity
HEP81_RS13020	COG0280	phosphate acetyltransferase
HEP81_RS13020	COG0857	belongs to the CobB CobQ family
HEP81_RS13025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEP81_RS13060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS13060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS13125	COG0183	Belongs to the thiolase family
HEP81_RS13180	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HEP81_RS13195	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP81_RS13225	COG4585	Histidine kinase
HEP81_RS13230	COG2197	response regulator
HEP81_RS13250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP81_RS13255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEP81_RS13260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEP81_RS13265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP81_RS13270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP81_RS13275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP81_RS13280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP81_RS13295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP81_RS13300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP81_RS13305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP81_RS13315	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP81_RS13320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP81_RS13325	COG0254	rRNA binding
HEP81_RS13340	COG0083	homoserine kinase activity
HEP81_RS13345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP81_RS13350	COG0460	homoserine dehydrogenase
HEP81_RS13355	COG0019	diaminopimelate decarboxylase activity
HEP81_RS13360	COG0018	arginyl-trna synthetase
HEP81_RS13385	COG0436	Aminotransferase
HEP81_RS13390	COG4566	intracellular signal transduction
HEP81_RS13395	COG1720	tRNA m6t6A37 methyltransferase activity
HEP81_RS13415	COG0626	cystathionine gamma-synthase activity
HEP81_RS13425	COG1720	tRNA m6t6A37 methyltransferase activity
HEP81_RS13445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS13455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP81_RS13460	COG3903	Transcriptional regulator
HEP81_RS13460	COG3629	intracellular signal transduction
HEP81_RS13470	COG1609	Transcriptional regulator
HEP81_RS13475	COG4209	transmembrane transport
HEP81_RS13480	COG0395	ABC-type sugar transport system, permease component
HEP81_RS13490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP81_RS13500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP81_RS13505	COG1793	dna ligase
HEP81_RS13505	COG3285	dna ligase
HEP81_RS13525	COG2205	protein histidine kinase activity
HEP81_RS13535	COG0768	penicillin binding
HEP81_RS13575	COG1309	transcriptional regulator
HEP81_RS13630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEP81_RS13645	COG0745	RESPONSE REGULATOR receiver
HEP81_RS13650	COG2205	protein histidine kinase activity
HEP81_RS13655	COG0567	Dehydrogenase, E1 component
HEP81_RS13655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP81_RS13675	COG0604	alcohol dehydrogenase
HEP81_RS13680	COG0281	malic enzyme
HEP81_RS13695	COG1126	abc transporter atp-binding protein
HEP81_RS13700	COG4106	trans-aconitate 2-methyltransferase activity
HEP81_RS13760	COG0142	geranyltranstransferase activity
HEP81_RS13765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP81_RS13770	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HEP81_RS13785	COG2172	sigma factor antagonist activity
HEP81_RS13800	COG1597	lipid kinase activity
HEP81_RS13815	COG0363	glucosamine-6-phosphate deaminase activity
HEP81_RS13820	COG2188	Transcriptional regulator
HEP81_RS13850	COG4977	sequence-specific DNA binding
HEP81_RS13855	COG2124	cytochrome p450
HEP81_RS13865	COG0242	peptide deformylase activity
HEP81_RS13875	COG5662	AntiSigma factor
HEP81_RS13880	COG1595	DNA-templated transcription, initiation
HEP81_RS13890	COG2135	peptidase activity
HEP81_RS13900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEP81_RS13910	COG2076	Multidrug Resistance protein
HEP81_RS13930	COG0483	inositol monophosphate 1-phosphatase activity
HEP81_RS13940	COG0753	catalase activity
HEP81_RS13965	COG1615	UPF0182 protein
HEP81_RS13975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP81_RS14030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP81_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP81_RS14110	COG1846	Transcriptional regulator
HEP81_RS14140	COG4172	Belongs to the ABC transporter superfamily
HEP81_RS14145	COG0601	transmembrane transport
HEP81_RS14150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP81_RS14195	COG0513	Belongs to the DEAD box helicase family
HEP81_RS14205	COG1432	Conserved Protein
HEP81_RS14215	COG2095	MarC family integral membrane protein
HEP81_RS14230	COG2814	Major facilitator Superfamily
HEP81_RS14240	COG0598	Magnesium transport protein CorA
HEP81_RS14275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP81_RS14280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP81_RS14290	COG1595	DNA-templated transcription, initiation
HEP81_RS14305	COG1024	Enoyl-CoA hydratase
HEP81_RS14310	COG0519	Catalyzes the synthesis of GMP from XMP
HEP81_RS14320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP81_RS14325	COG1611	Belongs to the LOG family
HEP81_RS14330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP81_RS14365	COG2197	response regulator
HEP81_RS14370	COG4585	Histidine kinase
HEP81_RS14380	COG1131	(ABC) transporter
HEP81_RS14395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP81_RS14410	COG4608	Belongs to the ABC transporter superfamily
HEP81_RS14415	COG0444	Belongs to the ABC transporter superfamily
HEP81_RS14420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP81_RS14425	COG0601	transmembrane transport
HEP81_RS14430	COG4166	transmembrane transport
HEP81_RS14435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP81_RS14440	COG0747	negative chemotaxis
HEP81_RS14450	COG0444	Belongs to the ABC transporter superfamily
HEP81_RS14455	COG4608	Belongs to the ABC transporter superfamily
HEP81_RS14460	COG0346	lactoylglutathione lyase activity
HEP81_RS14470	COG4608	Belongs to the ABC transporter superfamily
HEP81_RS14475	COG0444	Belongs to the ABC transporter superfamily
HEP81_RS14480	COG0601	transmembrane transport
HEP81_RS14485	COG0747	negative chemotaxis
HEP81_RS14495	COG1217	gtp-binding protein TYPA
HEP81_RS14515	COG1053	succinate dehydrogenase
HEP81_RS14590	COG2003	Belongs to the UPF0758 family
HEP81_RS14615	COG0012	GTP binding
HEP81_RS14630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP81_RS14635	COG1570	exodeoxyribonuclease VII activity
HEP81_RS14640	COG1722	exodeoxyribonuclease VII activity
HEP81_RS14645	COG0778	Nitroreductase
HEP81_RS14670	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP81_RS14670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP81_RS14675	COG0114	fumarate hydratase activity
HEP81_RS14690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP81_RS14700	COG1136	(ABC) transporter
HEP81_RS14715	COG0450	alkyl hydroperoxide reductase
HEP81_RS14720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP81_RS14735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP81_RS14740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP81_RS14745	COG2226	methyltransferase
HEP81_RS14755	COG2885	chlorophyll binding
HEP81_RS14775	COG2197	response regulator
HEP81_RS14810	COG2894	cell division
HEP81_RS14870	COG0251	oxidation-reduction process
HEP81_RS14875	COG1414	Transcriptional regulator
HEP81_RS14890	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEP81_RS14905	COG0436	Aminotransferase
HEP81_RS14925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HEP81_RS14940	COG1309	transcriptional regulator
HEP81_RS14955	COG1331	Highly conserved protein containing a thioredoxin domain
HEP81_RS14965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP81_RS14975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP81_RS14980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP81_RS14985	COG2255	four-way junction helicase activity
HEP81_RS14990	COG1595	DNA-templated transcription, initiation
HEP81_RS15010	COG0501	Belongs to the peptidase M48B family
HEP81_RS15025	COG1064	alcohol dehydrogenase
HEP81_RS15035	COG1136	(ABC) transporter
HEP81_RS15065	COG2986	histidine ammonia-lyase
HEP81_RS15075	COG1024	Enoyl-CoA hydratase
HEP81_RS15085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP81_RS15095	COG2267	carboxylic ester hydrolase activity
HEP81_RS15110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP81_RS15125	COG0424	maF-like protein
HEP81_RS15135	COG4770	biotin carboxylase activity
HEP81_RS15160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP81_RS15170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEP81_RS15175	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS15180	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS15195	COG1595	DNA-templated transcription, initiation
HEP81_RS15200	COG0745	RESPONSE REGULATOR receiver
HEP81_RS15205	COG2205	protein histidine kinase activity
HEP81_RS15230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP81_RS15240	COG0583	DNA-binding transcription factor activity
HEP81_RS15245	COG2814	Major facilitator Superfamily
HEP81_RS15280	COG1079	Belongs to the binding-protein-dependent transport system permease family
HEP81_RS15285	COG4603	Belongs to the binding-protein-dependent transport system permease family
HEP81_RS15290	COG3845	ABC transporter
HEP81_RS15295	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP81_RS15300	COG1473	amidohydrolase
HEP81_RS15300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEP81_RS15315	COG2089	acid synthase
HEP81_RS15330	COG1216	Glycosyl transferase, family 2
HEP81_RS15365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS15365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS15380	COG1595	DNA-templated transcription, initiation
HEP81_RS15410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP81_RS15420	COG2009	succinate dehydrogenase
HEP81_RS15430	COG1053	succinate dehydrogenase
HEP81_RS15450	COG1309	transcriptional regulator
HEP81_RS15475	COG1295	ribonuclease BN
HEP81_RS15490	COG0180	Tryptophanyl-tRNA synthetase
HEP81_RS15495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP81_RS15500	COG0754	glutathionylspermidine amidase activity
HEP81_RS15520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP81_RS15525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP81_RS15540	COG4176	ABC-type proline glycine betaine transport system permease component
HEP81_RS15545	COG0517	IMP dehydrogenase activity
HEP81_RS15545	COG4175	Glycine betaine
HEP81_RS15555	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS15565	COG0477	Major facilitator Superfamily
HEP81_RS15570	COG0039	L-malate dehydrogenase activity
HEP81_RS15585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP81_RS15605	COG2815	serine threonine protein kinase
HEP81_RS15605	COG0515	serine threonine protein kinase
HEP81_RS15615	COG0138	bifunctional purine biosynthesis protein purh
HEP81_RS15645	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP81_RS15650	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP81_RS15665	COG0714	Associated with various cellular activities
HEP81_RS15680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS15680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS15690	COG0739	heme binding
HEP81_RS15715	COG2197	response regulator
HEP81_RS15760	COG0519	Catalyzes the synthesis of GMP from XMP
HEP81_RS15760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HEP81_RS15775	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS15780	COG0515	serine threonine protein kinase
HEP81_RS15790	COG0515	serine threonine protein kinase
HEP81_RS15795	COG0515	serine threonine protein kinase
HEP81_RS15795	COG2815	serine threonine protein kinase
HEP81_RS15800	COG0515	serine threonine protein kinase
HEP81_RS15805	COG0515	serine threonine protein kinase
HEP81_RS15805	COG2815	serine threonine protein kinase
HEP81_RS15815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP81_RS15830	COG0516	GMP reductase activity
HEP81_RS15840	COG1595	DNA-templated transcription, initiation
HEP81_RS15855	COG0583	DNA-binding transcription factor activity
HEP81_RS15865	COG4221	oxidoreductase activity
HEP81_RS15875	COG0459	protein refolding
HEP81_RS15885	COG0726	polysaccharide deacetylase
HEP81_RS15890	COG0726	polysaccharide deacetylase
HEP81_RS15910	COG1653	transport
HEP81_RS15915	COG1175	transmembrane transport
HEP81_RS15935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEP81_RS15955	COG0802	atpase or kinase
HEP81_RS15965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEP81_RS15975	COG0736	holo-[acyl-carrier-protein] synthase activity
HEP81_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS15985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP81_RS15995	COG1072	(Pantothenic acid kinase))
HEP81_RS16000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP81_RS16005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEP81_RS16010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEP81_RS16020	COG0101	tRNA pseudouridine synthase activity
HEP81_RS16025	COG0203	ribosomal protein L17
HEP81_RS16030	COG0202	RNA polymerase activity
HEP81_RS16035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEP81_RS16040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEP81_RS16045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEP81_RS16050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEP81_RS16060	COG0563	adenylate kinase activity
HEP81_RS16070	COG0200	Binds to the 23S rRNA
HEP81_RS16075	COG1841	ribosomal large subunit assembly
HEP81_RS16080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEP81_RS16085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEP81_RS16090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEP81_RS16095	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEP81_RS16100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP81_RS16105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP81_RS16110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP81_RS16115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEP81_RS16120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP81_RS16125	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP81_RS16130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEP81_RS16135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEP81_RS16140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEP81_RS16145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEP81_RS16150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP81_RS16155	COG0089	rRNA binding
HEP81_RS16160	COG0088	Forms part of the polypeptide exit tunnel
HEP81_RS16165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEP81_RS16170	COG0051	transcription antitermination factor activity, RNA binding
HEP81_RS16240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP81_RS16245	COG0049	tRNA binding
HEP81_RS16250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEP81_RS16265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP81_RS16270	COG0085	RNA polymerase activity
HEP81_RS16275	COG0222	ribosome binding
HEP81_RS16280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEP81_RS16290	COG0081	regulation of translation
HEP81_RS16295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP81_RS16300	COG0250	Participates in transcription elongation, termination and antitermination
HEP81_RS16315	COG0436	Aminotransferase
HEP81_RS16320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP81_RS16325	COG2801	Transposase and inactivated derivatives
HEP81_RS16325	COG3415	Transposase
HEP81_RS16330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP81_RS16365	COG0477	Major facilitator Superfamily
HEP81_RS16380	COG2030	dehydratase
HEP81_RS16385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP81_RS16405	COG0702	epimerase
HEP81_RS16430	COG1666	GTP binding
HEP81_RS16435	COG2261	transglycosylase associated protein
HEP81_RS16450	COG0501	Belongs to the peptidase M48B family
HEP81_RS16455	COG1007	ATP synthesis coupled electron transport
HEP81_RS16460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16470	COG0713	ATP synthesis coupled electron transport
HEP81_RS16475	COG0839	Belongs to the complex I subunit 6 family
HEP81_RS16480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP81_RS16490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16515	COG2197	response regulator
HEP81_RS16520	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEP81_RS16520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEP81_RS16525	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEP81_RS16530	COG0702	epimerase
HEP81_RS16565	COG0142	geranyltranstransferase activity
HEP81_RS16570	COG3953	SLT domain
HEP81_RS16570	COG5412	phage tail tape measure protein
HEP81_RS16575	COG0561	phosphatase activity
HEP81_RS16580	COG0492	ferredoxin-NADP+ reductase activity
HEP81_RS16610	COG1007	ATP synthesis coupled electron transport
HEP81_RS16620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP81_RS16625	COG0713	ATP synthesis coupled electron transport
HEP81_RS16630	COG0839	Belongs to the complex I subunit 6 family
HEP81_RS16635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP81_RS16645	COG1034	ATP synthesis coupled electron transport
HEP81_RS16650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP81_RS16660	COG0649	NAD binding
HEP81_RS16665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP81_RS16685	COG0242	peptide deformylase activity
HEP81_RS16705	COG2226	methyltransferase
HEP81_RS16715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP81_RS16735	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP81_RS16740	COG1278	Cold shock
HEP81_RS16745	COG2226	methyltransferase
HEP81_RS16760	COG3629	intracellular signal transduction
HEP81_RS16805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEP81_RS16815	COG1309	transcriptional regulator
HEP81_RS16830	COG1573	uracil-dna glycosylase
HEP81_RS16840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP81_RS16850	COG0163	prenyltransferase activity
HEP81_RS16860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEP81_RS16905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEP81_RS16910	COG1333	cytochrome c biogenesis protein
HEP81_RS16915	COG0785	Cytochrome C biogenesis protein
HEP81_RS16930	COG0406	alpha-ribazole phosphatase activity
HEP81_RS16935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP81_RS16960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEP81_RS16985	COG1191	sigma factor activity
HEP81_RS17000	COG0515	serine threonine protein kinase
HEP81_RS17000	COG2815	serine threonine protein kinase
HEP81_RS17035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP81_RS17035	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP81_RS17040	COG2205	protein histidine kinase activity
HEP81_RS17045	COG0745	RESPONSE REGULATOR receiver
HEP81_RS17055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS17060	COG1742	UPF0060 membrane protein
HEP81_RS17085	COG1690	Belongs to the RtcB family
HEP81_RS17120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HEP81_RS17125	COG0018	arginyl-trna synthetase
HEP81_RS17165	COG2910	NAD(P)H-binding
HEP81_RS17170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS17175	COG0113	porphobilinogen synthase activity
HEP81_RS17215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP81_RS17215	COG1648	precorrin-2 dehydrogenase activity
HEP81_RS17220	COG0181	hydroxymethylbilane synthase activity
HEP81_RS17225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP81_RS17230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEP81_RS17280	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEP81_RS17285	COG0738	Major facilitator superfamily
HEP81_RS17320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEP81_RS17335	COG1129	ABC transporter
HEP81_RS17335	COG0842	Transport permease protein
HEP81_RS17350	COG4991	sh3 domain protein
HEP81_RS17355	COG0515	serine threonine protein kinase
HEP81_RS17355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP81_RS17360	COG0129	dihydroxy-acid dehydratase activity
HEP81_RS17370	COG1082	Xylose isomerase domain protein TIM barrel
HEP81_RS17375	COG0248	Ppx GppA phosphatase
HEP81_RS17395	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HEP81_RS17405	COG1194	a g-specific adenine glycosylase
HEP81_RS17410	COG1595	DNA-templated transcription, initiation
HEP81_RS17420	COG0745	RESPONSE REGULATOR receiver
HEP81_RS17425	COG2205	protein histidine kinase activity
HEP81_RS17430	COG2814	Major facilitator Superfamily
HEP81_RS17435	COG0789	Transcriptional regulator
HEP81_RS17440	COG0477	Major facilitator Superfamily
HEP81_RS17450	COG0739	heme binding
HEP81_RS17475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEP81_RS17495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEP81_RS17505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEP81_RS17510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEP81_RS17525	COG2197	response regulator
HEP81_RS17540	COG0649	NAD binding
HEP81_RS17570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP81_RS17585	COG0302	gtp cyclohydrolase
HEP81_RS17600	COG0037	tRNA processing
HEP81_RS17610	COG2027	D-alanyl-D-alanine carboxypeptidase
HEP81_RS17615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP81_RS17625	COG0586	Pfam SNARE associated Golgi protein
HEP81_RS17630	COG0393	Putative heavy-metal-binding
HEP81_RS17635	COG0789	Transcriptional regulator
HEP81_RS17640	COG0076	glutamate decarboxylase activity
HEP81_RS17645	COG2318	DinB family
HEP81_RS17650	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS17690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP81_RS17690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP81_RS17695	COG3629	intracellular signal transduction
HEP81_RS17695	COG3903	Transcriptional regulator
HEP81_RS17735	COG0367	asparagine synthase
HEP81_RS17755	COG2124	cytochrome p450
HEP81_RS17760	COG0583	DNA-binding transcription factor activity
HEP81_RS17765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP81_RS17775	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEP81_RS17780	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEP81_RS17780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEP81_RS17805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEP81_RS17810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP81_RS17810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP81_RS17820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP81_RS17865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP81_RS17870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP81_RS17870	COG1754	DNA topoisomerase type I activity
HEP81_RS17890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP81_RS17895	COG2172	sigma factor antagonist activity
HEP81_RS17900	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS17905	COG1205	dead DEAH box helicase
HEP81_RS17905	COG1111	helicase
HEP81_RS17965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP81_RS17980	COG2267	carboxylic ester hydrolase activity
HEP81_RS18015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP81_RS18040	COG0003	Pfam Anion-transporting ATPase
HEP81_RS18060	COG1408	metallophosphoesterase
HEP81_RS18080	COG1309	transcriptional regulator
HEP81_RS18085	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP81_RS18120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP81_RS18135	COG1937	Protein conserved in bacteria
HEP81_RS18165	COG1595	DNA-templated transcription, initiation
HEP81_RS18185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEP81_RS18190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEP81_RS18205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP81_RS18210	COG1802	Transcriptional regulator
HEP81_RS18220	COG0737	Belongs to the 5'-nucleotidase family
HEP81_RS18225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP81_RS18245	COG1131	(ABC) transporter
HEP81_RS18250	COG3559	Exporter of polyketide antibiotics
HEP81_RS18260	COG2197	response regulator
HEP81_RS18265	COG4585	Histidine kinase
HEP81_RS18270	COG2197	response regulator
HEP81_RS18275	COG4585	Histidine kinase
HEP81_RS18290	COG3844	kynureninase activity
HEP81_RS18295	COG3483	tryptophan 2,3-dioxygenase activity
HEP81_RS18305	COG0477	Major facilitator Superfamily
HEP81_RS18315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP81_RS18330	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEP81_RS18365	COG0542	response to heat
HEP81_RS18395	COG4213	ABC transporter substrate-binding protein
HEP81_RS18400	COG0789	Transcriptional regulator
HEP81_RS18405	COG0484	heat shock protein binding
HEP81_RS18410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP81_RS18415	COG0443	Heat shock 70 kDa protein
HEP81_RS18420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP81_RS18425	COG2181	nitrate reductase activity
HEP81_RS18425	COG0247	lactate metabolic process
HEP81_RS18440	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HEP81_RS18445	COG0717	Belongs to the dCTP deaminase family
HEP81_RS18465	COG3693	PFAM glycoside hydrolase, family 10
HEP81_RS18475	COG1595	DNA-templated transcription, initiation
HEP81_RS18515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP81_RS18525	COG0385	Bile acid
HEP81_RS18560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP81_RS18570	COG1278	Cold shock
HEP81_RS18615	COG3903	Transcriptional regulator
HEP81_RS18615	COG3629	intracellular signal transduction
HEP81_RS18635	COG1595	DNA-templated transcription, initiation
HEP81_RS18650	COG2188	Transcriptional regulator
HEP81_RS18675	COG0701	Predicted permease
HEP81_RS18685	COG2255	four-way junction helicase activity
HEP81_RS18725	COG0366	Alpha amylase catalytic
HEP81_RS18730	COG1957	nucleoside hydrolase
HEP81_RS18785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP81_RS18795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP81_RS18805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEP81_RS18820	COG1741	Belongs to the pirin family
HEP81_RS18830	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS18835	COG1362	aminopeptidase activity
HEP81_RS18870	COG2271	Major facilitator Superfamily
HEP81_RS18905	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP81_RS18910	COG0022	dehydrogenase e1 component
HEP81_RS18925	COG0515	serine threonine protein kinase
HEP81_RS18930	COG0515	serine threonine protein kinase
HEP81_RS18945	COG3321	synthase
HEP81_RS18945	COG0604	alcohol dehydrogenase
HEP81_RS18945	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS18950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP81_RS18955	COG0303	'Molybdopterin
HEP81_RS18980	COG1522	sequence-specific DNA binding
HEP81_RS18990	COG1309	transcriptional regulator
HEP81_RS18995	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP81_RS19020	COG3396	Phenylacetate-CoA oxygenase
HEP81_RS19025	COG3460	Phenylacetate-CoA oxygenase
HEP81_RS19030	COG3396	Phenylacetate-CoA oxygenase
HEP81_RS19035	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP81_RS19040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP81_RS19070	COG0477	Major facilitator Superfamily
HEP81_RS19105	COG1716	ATPase activity
HEP81_RS19110	COG1716	ATPase activity
HEP81_RS19115	COG3266	domain, Protein
HEP81_RS19115	COG0631	protein serine/threonine phosphatase activity
HEP81_RS19125	COG0768	penicillin binding
HEP81_RS19130	COG0515	serine threonine protein kinase
HEP81_RS19135	COG3764	Sortase (surface protein transpeptidase)
HEP81_RS19140	COG3764	Sortase (surface protein transpeptidase)
HEP81_RS19155	COG3764	Sortase (surface protein transpeptidase)
HEP81_RS19170	COG0705	Rhomboid family
HEP81_RS19200	COG0515	serine threonine protein kinase
HEP81_RS19235	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP81_RS19235	COG2319	Wd-40 repeat
HEP81_RS19260	COG3266	domain, Protein
HEP81_RS19265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP81_RS19270	COG0187	DNA topoisomerase II activity
HEP81_RS19275	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HEP81_RS19280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP81_RS19285	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP81_RS19290	COG0592	DNA-directed DNA polymerase activity
HEP81_RS19295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HEP81_RS19300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEP81_RS19305	COG0594	ribonuclease P activity
HEP81_RS19310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEP81_RS19315	COG0706	membrane insertase activity
HEP81_RS19325	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP81_RS19330	COG1192	Involved in chromosome partitioning
HEP81_RS19345	COG3118	belongs to the thioredoxin family
HEP81_RS19350	COG0492	ferredoxin-NADP+ reductase activity
HEP81_RS19360	COG1595	DNA-templated transcription, initiation
HEP81_RS19365	COG2815	serine threonine protein kinase
HEP81_RS19365	COG0515	serine threonine protein kinase
HEP81_RS19380	COG0617	tRNA 3'-terminal CCA addition
HEP81_RS19390	COG1260	myo-inositol-1-phosphate synthase
HEP81_RS19400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP81_RS19425	COG0360	Binds together with S18 to 16S ribosomal RNA
HEP81_RS19430	COG0629	single-stranded DNA binding
HEP81_RS19435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP81_RS19440	COG0359	binds to the 23S rRNA
HEP81_RS19450	COG0305	Participates in initiation and elongation during chromosome replication
HEP81_RS19480	COG2814	Major facilitator Superfamily
HEP81_RS19505	COG0626	cystathionine gamma-synthase activity
HEP81_RS19510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP81_RS19515	COG1950	PFAM Membrane protein of
HEP81_RS19520	COG0662	Cupin 2, conserved barrel domain protein
HEP81_RS19530	COG1414	Transcriptional regulator
HEP81_RS19545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEP81_RS19560	COG1609	Transcriptional regulator
HEP81_RS19565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP81_RS19570	COG1271	oxidase subunit
HEP81_RS19575	COG1294	oxidase, subunit
HEP81_RS19580	COG4988	ABC transporter
HEP81_RS19585	COG0561	phosphatase activity
HEP81_RS19595	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP81_RS19610	COG1131	(ABC) transporter
HEP81_RS19635	COG0561	phosphatase activity
HEP81_RS19640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEP81_RS19650	COG2837	iron assimilation
HEP81_RS19665	COG1999	signal sequence binding
HEP81_RS19690	COG0006	proline dipeptidase activity
HEP81_RS19710	COG0653	protein targeting
HEP81_RS19725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP81_RS19770	COG1595	DNA-templated transcription, initiation
HEP81_RS19775	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS19810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP81_RS19810	COG1672	PFAM Archaeal ATPase
HEP81_RS19835	COG0745	RESPONSE REGULATOR receiver
HEP81_RS19840	COG2205	protein histidine kinase activity
HEP81_RS19845	COG0463	Glycosyl transferase, family 2
HEP81_RS19850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP81_RS19860	COG3467	pyridoxamine 5'-phosphate
HEP81_RS19895	COG1191	sigma factor activity
HEP81_RS19900	COG1191	sigma factor activity
HEP81_RS19935	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP81_RS19950	COG0433	COG0433 Predicted ATPase
HEP81_RS19980	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS20005	COG0151	Belongs to the GarS family
HEP81_RS20020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEP81_RS20030	COG2197	response regulator
HEP81_RS20065	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP81_RS20070	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP81_RS20075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP81_RS20100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEP81_RS20135	COG1643	Atp-dependent helicase
HEP81_RS20180	COG0513	Belongs to the DEAD box helicase family
HEP81_RS20210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEP81_RS20215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP81_RS20215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP81_RS20240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEP81_RS20245	COG0579	oxidoreductase
HEP81_RS20275	COG1252	NADH dehydrogenase
HEP81_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS20375	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS20385	COG0791	NLP P60 protein
HEP81_RS20390	COG0671	phosphoesterase, PA-phosphatase related
HEP81_RS20395	COG0277	FAD linked oxidase domain protein
HEP81_RS20415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEP81_RS20450	COG0306	phosphate transporter
HEP81_RS20460	COG1937	Protein conserved in bacteria
HEP81_RS20480	COG0494	nUDIX hydrolase
HEP81_RS20480	COG0406	alpha-ribazole phosphatase activity
HEP81_RS20490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP81_RS20500	COG1131	(ABC) transporter
HEP81_RS20505	COG1725	Transcriptional regulator
HEP81_RS20510	COG0456	acetyltransferase
HEP81_RS20515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP81_RS20525	COG0745	RESPONSE REGULATOR receiver
HEP81_RS20535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP81_RS20540	COG1609	Transcriptional regulator
HEP81_RS20545	COG0745	RESPONSE REGULATOR receiver
HEP81_RS20605	COG2897	thiosulfate sulfurtransferase activity
HEP81_RS20620	COG3485	protocatechuate 3,4-dioxygenase
HEP81_RS20630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP81_RS20635	COG1490	D-aminoacyl-tRNA deacylase activity
HEP81_RS20645	COG4552	Acetyltransferase involved in intracellular survival and related
HEP81_RS20650	COG2188	Transcriptional regulator
HEP81_RS20660	COG1802	Transcriptional regulator
HEP81_RS20665	COG0546	phosphoglycolate phosphatase activity
HEP81_RS20675	COG1309	transcriptional regulator
HEP81_RS20685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP81_RS20695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP81_RS20720	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP81_RS20740	COG2204	response regulator
HEP81_RS20745	COG3883	PFAM NLP P60 protein
HEP81_RS20745	COG0791	NLP P60 protein
HEP81_RS20755	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS20785	COG0588	phosphoglycerate mutase activity
HEP81_RS20800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP81_RS20805	COG0798	PFAM Bile acid sodium symporter
HEP81_RS20810	COG0640	Transcriptional regulator
HEP81_RS20830	COG5002	protein histidine kinase activity
HEP81_RS20845	COG1329	Transcriptional regulator
HEP81_RS20850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP81_RS20855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP81_RS20885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP81_RS20890	COG0215	cysteine-tRNA ligase activity
HEP81_RS20895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP81_RS20905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEP81_RS20915	COG3842	ATPase activity
HEP81_RS20925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP81_RS20930	COG2329	Antibiotic biosynthesis monooxygenase
HEP81_RS20945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP81_RS20950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS20955	COG2867	negative regulation of translational initiation
HEP81_RS21030	COG5001	Diguanylate cyclase
HEP81_RS21030	COG3300	MHYT domain
HEP81_RS21055	COG1653	transport
HEP81_RS21075	COG0463	Glycosyl transferase, family 2
HEP81_RS21080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP81_RS21090	COG1278	Cold shock
HEP81_RS21095	COG0459	protein refolding
HEP81_RS21110	COG1263	PTS System
HEP81_RS21110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP81_RS21115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEP81_RS21120	COG1737	Transcriptional regulator
HEP81_RS21170	COG2268	Band 7 protein
HEP81_RS21180	COG3973	AAA domain
HEP81_RS21195	COG1061	Type III restriction enzyme res subunit
HEP81_RS21220	COG1278	Cold shock
HEP81_RS21225	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP81_RS21230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEP81_RS21240	COG2814	Major facilitator Superfamily
HEP81_RS21265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP81_RS21275	COG2252	PERMEase
HEP81_RS21305	COG0667	Aldo Keto reductase
HEP81_RS21350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP81_RS21355	COG0247	lactate metabolic process
HEP81_RS21355	COG0277	FAD linked oxidase domain protein
HEP81_RS21390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP81_RS21405	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS21430	COG0259	pyridoxamine-phosphate oxidase activity
HEP81_RS21445	COG4821	SIS domain
HEP81_RS21465	COG1595	DNA-templated transcription, initiation
HEP81_RS21555	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS21565	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS21570	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS21585	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS21590	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS21620	COG1024	Enoyl-CoA hydratase
HEP81_RS21630	COG2072	flavoprotein involved in K transport
HEP81_RS21645	COG0259	pyridoxamine-phosphate oxidase activity
HEP81_RS21660	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS21670	COG1280	lysine exporter protein (LysE YggA)
HEP81_RS21675	COG1522	sequence-specific DNA binding
HEP81_RS21680	COG1309	transcriptional regulator
HEP81_RS21690	COG0515	serine threonine protein kinase
HEP81_RS21690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP81_RS21720	COG3903	Transcriptional regulator
HEP81_RS21720	COG3629	intracellular signal transduction
HEP81_RS21750	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS21765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP81_RS21810	COG1686	Belongs to the peptidase S11 family
HEP81_RS21835	COG0386	Belongs to the glutathione peroxidase family
HEP81_RS21840	COG0640	Transcriptional regulator
HEP81_RS21860	COG1523	belongs to the glycosyl hydrolase 13 family
HEP81_RS21890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP81_RS21965	COG0598	Magnesium transport protein CorA
HEP81_RS22015	COG4974	Belongs to the 'phage' integrase family
HEP81_RS22055	COG1846	Transcriptional regulator
HEP81_RS22060	COG3384	dioxygenase
HEP81_RS22065	COG1247	-acetyltransferase
HEP81_RS22100	COG1376	ErfK ybiS ycfS ynhG family protein
HEP81_RS22130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP81_RS22140	COG0477	Major facilitator Superfamily
HEP81_RS22155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP81_RS22160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP81_RS22170	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP81_RS22175	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP81_RS22175	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP81_RS22180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP81_RS22195	COG0454	-acetyltransferase
HEP81_RS22200	COG0708	Exodeoxyribonuclease III
HEP81_RS22205	COG0789	Transcriptional regulator
HEP81_RS22210	COG2072	flavoprotein involved in K transport
HEP81_RS22215	COG2267	carboxylic ester hydrolase activity
HEP81_RS22220	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS22230	COG4946	Tricorn protease homolog
HEP81_RS22230	COG0793	Belongs to the peptidase S41A family
HEP81_RS22240	COG2409	Drug exporters of the RND superfamily
HEP81_RS22260	COG0442	prolyl-tRNA aminoacylation
HEP81_RS22290	COG1122	ATPase activity
HEP81_RS22300	COG0310	cobalt ion transport
HEP81_RS22345	COG0084	hydrolase, TatD family'
HEP81_RS22355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP81_RS22360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP81_RS22365	COG0488	(ABC) transporter
HEP81_RS22405	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HEP81_RS22415	COG2197	response regulator
HEP81_RS22425	COG4106	trans-aconitate 2-methyltransferase activity
HEP81_RS22445	COG1309	transcriptional regulator
HEP81_RS22455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEP81_RS22465	COG0193	aminoacyl-tRNA hydrolase activity
HEP81_RS22470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEP81_RS22475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP81_RS22480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP81_RS22490	COG4585	Histidine kinase
HEP81_RS22520	COG1136	(ABC) transporter
HEP81_RS22525	COG0577	efflux transmembrane transporter activity
HEP81_RS22585	COG2124	cytochrome p450
HEP81_RS22595	COG1652	LysM domain
HEP81_RS22605	COG0148	phosphopyruvate hydratase activity
HEP81_RS22625	COG1252	NADH dehydrogenase
HEP81_RS22630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP81_RS22635	COG0577	efflux transmembrane transporter activity
HEP81_RS22640	COG1136	(ABC) transporter
HEP81_RS22640	COG0577	efflux transmembrane transporter activity
HEP81_RS22650	COG0582	viral genome integration into host DNA
HEP81_RS22815	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP81_RS23070	COG1475	DNA binding
HEP81_RS23090	COG1475	DNA binding
HEP81_RS23230	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS23390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP81_RS23395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP81_RS23430	COG0183	Belongs to the thiolase family
HEP81_RS23435	COG2755	lipolytic protein G-D-S-L family
HEP81_RS23500	COG0789	Transcriptional regulator
HEP81_RS23545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP81_RS23550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP81_RS23560	COG1228	amidohydrolase
HEP81_RS23565	COG1191	sigma factor activity
HEP81_RS23570	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS23600	COG3104	oligopeptide transport
HEP81_RS23605	COG0745	RESPONSE REGULATOR receiver
HEP81_RS23610	COG2205	protein histidine kinase activity
HEP81_RS23625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEP81_RS23650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP81_RS23670	COG1316	TRANSCRIPTIONal
HEP81_RS23680	COG1316	TRANSCRIPTIONal
HEP81_RS23690	COG1316	TRANSCRIPTIONal
HEP81_RS23695	COG1316	TRANSCRIPTIONal
HEP81_RS23700	COG1316	TRANSCRIPTIONal
HEP81_RS23720	COG0778	Nitroreductase
HEP81_RS23720	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEP81_RS23725	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP81_RS23770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP81_RS23775	COG2835	tetraacyldisaccharide 4'-kinase activity
HEP81_RS23785	COG1482	cell wall glycoprotein biosynthetic process
HEP81_RS23795	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEP81_RS23835	COG0714	Associated with various cellular activities
HEP81_RS23855	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP81_RS23925	COG2188	Transcriptional regulator
HEP81_RS23955	COG0745	RESPONSE REGULATOR receiver
HEP81_RS23960	COG5000	phosphorelay sensor kinase activity
HEP81_RS23960	COG5002	protein histidine kinase activity
HEP81_RS23965	COG0823	Involved in the tonB-independent uptake of proteins
HEP81_RS23975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEP81_RS23980	COG2197	response regulator
HEP81_RS23985	COG3214	Protein conserved in bacteria
HEP81_RS23995	COG0653	protein targeting
HEP81_RS24020	COG2902	Dehydrogenase
HEP81_RS24030	COG1215	transferase activity, transferring glycosyl groups
HEP81_RS24035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP81_RS24040	COG1134	teichoic acid transport
HEP81_RS24050	COG1309	transcriptional regulator
HEP81_RS24065	COG1215	transferase activity, transferring glycosyl groups
HEP81_RS24080	COG1846	Transcriptional regulator
HEP81_RS24085	COG1764	response to oxidative stress
HEP81_RS24090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP81_RS24090	COG0463	Glycosyl transferase, family 2
HEP81_RS24095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP81_RS24100	COG1216	Glycosyl transferase, family 2
HEP81_RS24120	COG0395	ABC-type sugar transport system, permease component
HEP81_RS24125	COG1175	transmembrane transport
HEP81_RS24130	COG1653	transport
HEP81_RS24135	COG1674	ftsk spoiiie
HEP81_RS24140	COG0515	serine threonine protein kinase
HEP81_RS24145	COG0515	serine threonine protein kinase
HEP81_RS24150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP81_RS24165	COG2884	Cell division ATP-binding protein ftsE
HEP81_RS24170	COG2177	Part of the ABC transporter FtsEX involved in
HEP81_RS24175	COG0793	Belongs to the peptidase S41A family
HEP81_RS24180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP81_RS24195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP81_RS24200	COG0277	FAD linked oxidase domain protein
HEP81_RS24210	COG3973	AAA domain
HEP81_RS24220	COG0776	regulation of translation
HEP81_RS24225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP81_RS24230	COG1678	Uncharacterized ACR, COG1678
HEP81_RS24240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP81_RS24315	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEP81_RS24325	COG0277	FAD linked oxidase domain protein
HEP81_RS24360	COG1335	isochorismatase
HEP81_RS24370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEP81_RS24380	COG1113	amino acid transport
HEP81_RS24420	COG1263	PTS System
HEP81_RS24425	COG1263	PTS System
HEP81_RS24430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP81_RS24435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP81_RS24450	COG1131	(ABC) transporter
HEP81_RS24465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP81_RS24505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP81_RS24515	COG2733	membrane
HEP81_RS24530	COG0071	Belongs to the small heat shock protein (HSP20) family
HEP81_RS24560	COG3764	Sortase (surface protein transpeptidase)
HEP81_RS24580	COG0706	membrane insertase activity
HEP81_RS24595	COG4702	Belongs to the UPF0303 family
HEP81_RS24600	COG0673	inositol 2-dehydrogenase activity
HEP81_RS24625	COG2188	Transcriptional regulator
HEP81_RS24635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP81_RS24675	COG2186	Transcriptional regulator
HEP81_RS24695	COG3397	chitin binding
HEP81_RS24710	COG1126	abc transporter atp-binding protein
HEP81_RS24715	COG0765	amino acid transport
HEP81_RS24720	COG0765	amino acid transport
HEP81_RS24725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP81_RS24730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP81_RS24740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS24790	COG0406	alpha-ribazole phosphatase activity
HEP81_RS24815	COG0745	RESPONSE REGULATOR receiver
HEP81_RS24825	COG3979	chitinase
HEP81_RS24855	COG0589	response to stress
HEP81_RS24865	COG4977	sequence-specific DNA binding
HEP81_RS24870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP81_RS24880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP81_RS24905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HEP81_RS24910	COG0076	glutamate decarboxylase activity
HEP81_RS24915	COG1132	(ABC) transporter
HEP81_RS24915	COG2375	cellular response to nickel ion
HEP81_RS24925	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS24940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP81_RS24945	COG1309	transcriptional regulator
HEP81_RS24955	COG1946	Acyl-CoA thioesterase
HEP81_RS24980	COG0028	Belongs to the TPP enzyme family
HEP81_RS25010	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP81_RS25025	COG1609	Transcriptional regulator
HEP81_RS25030	COG0673	inositol 2-dehydrogenase activity
HEP81_RS25045	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS25085	COG4941	Belongs to the sigma-70 factor family
HEP81_RS25095	COG1869	D-ribose catabolic process
HEP81_RS25100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP81_RS25110	COG1129	ABC transporter
HEP81_RS25120	COG0604	alcohol dehydrogenase
HEP81_RS25125	COG1902	pentaerythritol trinitrate reductase activity
HEP81_RS25130	COG1846	Transcriptional regulator
HEP81_RS25145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP81_RS25170	COG1063	alcohol dehydrogenase
HEP81_RS25180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP81_RS25190	COG3718	enzyme involved in inositol metabolism
HEP81_RS25195	COG3962	Belongs to the TPP enzyme family
HEP81_RS25210	COG1131	(ABC) transporter
HEP81_RS25275	COG2304	oxidoreductase activity
HEP81_RS25285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP81_RS25310	COG0629	single-stranded DNA binding
HEP81_RS25380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP81_RS25395	COG1486	melibiose metabolic process
HEP81_RS25400	COG0395	ABC-type sugar transport system, permease component
HEP81_RS25405	COG1175	transmembrane transport
HEP81_RS25425	COG0668	transmembrane transport
HEP81_RS25460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP81_RS25485	COG1595	DNA-templated transcription, initiation
HEP81_RS25540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP81_RS25550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEP81_RS25560	COG1113	amino acid transport
HEP81_RS25575	COG1116	anion transmembrane transporter activity
HEP81_RS25580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP81_RS25590	COG1940	carbohydrate kinase activity
HEP81_RS25600	COG1113	amino acid transport
HEP81_RS25605	COG0698	ribose 5-phosphate isomerase
HEP81_RS25635	COG3594	Acyltransferase
HEP81_RS25665	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP81_RS25670	COG0740	serine-type endopeptidase activity
HEP81_RS25675	COG0740	serine-type endopeptidase activity
HEP81_RS25680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP81_RS25690	COG0525	valine-tRNA ligase activity
HEP81_RS25695	COG0285	dihydrofolate synthase activity
HEP81_RS25705	COG0105	UTP biosynthetic process
HEP81_RS25710	COG1077	Cell shape determining protein MreB Mrl
HEP81_RS25725	COG0768	penicillin binding
HEP81_RS25730	COG0772	Belongs to the SEDS family
HEP81_RS25765	COG1530	ribonuclease E activity
HEP81_RS25780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP81_RS25785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP81_RS25790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP81_RS25795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP81_RS25800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP81_RS25805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEP81_RS25815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP81_RS25830	COG0501	Belongs to the peptidase M48B family
HEP81_RS25845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP81_RS25855	COG0799	negative regulation of ribosome biogenesis
HEP81_RS25860	COG0588	phosphoglycerate mutase activity
HEP81_RS25880	COG0495	leucyl-tRNA aminoacylation
HEP81_RS25890	COG1307	EDD domain protein, DegV family
HEP81_RS25895	COG1555	photosystem II stabilization
HEP81_RS25910	COG2353	YceI-like domain
HEP81_RS25925	COG0268	Binds directly to 16S ribosomal RNA
HEP81_RS25930	COG0481	GTPase activity
HEP81_RS25965	COG1420	regulation of RNA biosynthetic process
HEP81_RS25970	COG0484	heat shock protein binding
HEP81_RS25995	COG4946	Tricorn protease homolog
HEP81_RS25995	COG0793	Belongs to the peptidase S41A family
HEP81_RS26005	COG0537	adenosine 5'-monophosphoramidase activity
HEP81_RS26010	COG1234	tRNA 3'-trailer cleavage
HEP81_RS26015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP81_RS26030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP81_RS26040	COG2315	Protein conserved in bacteria
HEP81_RS26045	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEP81_RS26080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP81_RS26110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP81_RS26135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP81_RS26140	COG4608	Belongs to the ABC transporter superfamily
HEP81_RS26145	COG0444	Belongs to the ABC transporter superfamily
HEP81_RS26155	COG0747	negative chemotaxis
HEP81_RS26185	COG5297	Belongs to the glycosyl hydrolase family 6
HEP81_RS26195	COG1381	Involved in DNA repair and RecF pathway recombination
HEP81_RS26200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP81_RS26210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEP81_RS26215	COG1121	(ABC) transporter
HEP81_RS26225	COG0423	glycine-tRNA ligase activity
HEP81_RS26235	COG0667	Aldo Keto reductase
HEP81_RS26250	COG0477	Major facilitator Superfamily
HEP81_RS26280	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HEP81_RS26285	COG1846	Transcriptional regulator
HEP81_RS26285	COG1940	carbohydrate kinase activity
HEP81_RS26290	COG0574	Belongs to the PEP-utilizing enzyme family
HEP81_RS26290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP81_RS26305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEP81_RS26320	COG1175	transmembrane transport
HEP81_RS26325	COG0395	ABC-type sugar transport system, permease component
HEP81_RS26350	COG2949	membrane
HEP81_RS26355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HEP81_RS26365	COG0358	DNA primase activity
HEP81_RS26370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP81_RS26385	COG1070	Carbohydrate kinase
HEP81_RS26430	COG1077	Cell shape determining protein MreB Mrl
HEP81_RS26455	COG1404	Belongs to the peptidase S8 family
HEP81_RS26460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP81_RS26460	COG0825	malonyl-CoA metabolic process
HEP81_RS26465	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS26520	COG0477	Major facilitator Superfamily
HEP81_RS26550	COG2130	NADP-dependent
HEP81_RS26575	COG1335	isochorismatase
HEP81_RS26580	COG1335	isochorismatase
HEP81_RS26610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP81_RS26615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS26620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP81_RS26655	COG0789	Transcriptional regulator
HEP81_RS26660	COG0667	Aldo Keto reductase
HEP81_RS26675	COG1309	transcriptional regulator
HEP81_RS26680	COG0477	Major facilitator Superfamily
HEP81_RS26685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP81_RS26730	COG1358	cellular component organization or biogenesis
HEP81_RS26745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP81_RS26790	COG3973	AAA domain
HEP81_RS26810	COG3415	Transposase
HEP81_RS26810	COG2801	Transposase and inactivated derivatives
HEP81_RS26830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP81_RS26865	COG0583	DNA-binding transcription factor activity
HEP81_RS26880	COG4122	O-methyltransferase activity
HEP81_RS26890	COG0477	Major facilitator Superfamily
HEP81_RS26900	COG0183	Belongs to the thiolase family
HEP81_RS26905	COG2124	cytochrome p450
HEP81_RS26910	COG3619	membrane
HEP81_RS26915	COG0741	lytic transglycosylase activity
HEP81_RS26925	COG3845	ABC transporter
HEP81_RS26990	COG1309	transcriptional regulator
HEP81_RS26995	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS27015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS27025	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEP81_RS27025	COG2247	cell wall binding repeat
HEP81_RS27035	COG0477	Major facilitator Superfamily
HEP81_RS27055	COG2197	response regulator
HEP81_RS27060	COG4585	Histidine kinase
HEP81_RS27070	COG1131	(ABC) transporter
HEP81_RS27075	COG2030	dehydratase
HEP81_RS27085	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS27095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEP81_RS27110	COG0800	Aldolase
HEP81_RS27115	COG3022	response to hydroperoxide
HEP81_RS27120	COG0557	exoribonuclease II activity
HEP81_RS27210	COG2259	Doxx family
HEP81_RS27220	COG1686	Belongs to the peptidase S11 family
HEP81_RS27230	COG2814	Major facilitator Superfamily
HEP81_RS27235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP81_RS27255	COG0672	)-iron permease
HEP81_RS27260	COG2837	iron assimilation
HEP81_RS27270	COG1120	ATPase activity
HEP81_RS27315	COG1994	Peptidase M50
HEP81_RS27345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP81_RS27350	COG0477	Major facilitator Superfamily
HEP81_RS27365	COG2814	Major facilitator Superfamily
HEP81_RS27410	COG0583	DNA-binding transcription factor activity
HEP81_RS27420	COG0596	Alpha beta hydrolase
HEP81_RS27440	COG1959	2 iron, 2 sulfur cluster binding
HEP81_RS27445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP81_RS27445	COG1017	nitric oxide dioxygenase activity
HEP81_RS27450	COG0174	glutamine synthetase
HEP81_RS27455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HEP81_RS27540	COG2816	NAD+ diphosphatase activity
HEP81_RS27550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP81_RS27560	COG0174	glutamine synthetase
HEP81_RS27575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP81_RS27585	COG1609	Transcriptional regulator
HEP81_RS27590	COG1653	transport
HEP81_RS27595	COG1175	transmembrane transport
HEP81_RS27600	COG3833	ABC-type maltose transport systems, permease component
HEP81_RS27605	COG0366	Alpha amylase catalytic
HEP81_RS27620	COG1309	transcriptional regulator
HEP81_RS27645	COG2197	response regulator
HEP81_RS27655	COG1090	epimerase
HEP81_RS27660	COG0745	RESPONSE REGULATOR receiver
HEP81_RS27695	COG0501	Belongs to the peptidase M48B family
HEP81_RS27725	COG0174	glutamine synthetase
HEP81_RS27745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP81_RS27750	COG0321	lipoyl(octanoyl) transferase activity
HEP81_RS27765	COG0456	acetyltransferase
HEP81_RS27765	COG0454	-acetyltransferase
HEP81_RS27790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP81_RS27800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP81_RS27805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP81_RS27810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP81_RS27815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEP81_RS27835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEP81_RS27855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP81_RS27880	COG4585	Histidine kinase
HEP81_RS27885	COG2197	response regulator
HEP81_RS27890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEP81_RS27895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEP81_RS27915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP81_RS27925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP81_RS27930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP81_RS27940	COG1376	ErfK ybiS ycfS ynhG family protein
HEP81_RS27950	COG1845	cytochrome c oxidase, subunit III
HEP81_RS27955	COG2010	Cytochrome c
HEP81_RS27960	COG0723	plastoquinol--plastocyanin reductase activity
HEP81_RS27965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP81_RS27970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP81_RS27975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP81_RS28005	COG3883	PFAM NLP P60 protein
HEP81_RS28005	COG0791	NLP P60 protein
HEP81_RS28020	COG0534	Mate efflux family protein
HEP81_RS28030	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS28050	COG0003	Pfam Anion-transporting ATPase
HEP81_RS28060	COG1940	carbohydrate kinase activity
HEP81_RS28085	COG4585	Histidine kinase
HEP81_RS28095	COG0205	6-phosphofructokinase activity
HEP81_RS28110	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP81_RS28120	COG2193	ferroxidase activity
HEP81_RS28125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP81_RS28130	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEP81_RS28135	COG0515	serine threonine protein kinase
HEP81_RS28135	COG2815	serine threonine protein kinase
HEP81_RS28140	COG2022	thiamine diphosphate biosynthetic process
HEP81_RS28150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP81_RS28150	COG2022	thiamine diphosphate biosynthetic process
HEP81_RS28170	COG0352	thiamine-phosphate diphosphorylase activity
HEP81_RS28195	COG1309	transcriptional regulator
HEP81_RS28200	COG1511	domain protein
HEP81_RS28205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HEP81_RS28235	COG0714	Associated with various cellular activities
HEP81_RS28245	COG0275	rRNA processing
HEP81_RS28260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEP81_RS28270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP81_RS28275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEP81_RS28285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP81_RS28290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HEP81_RS28295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP81_RS28300	COG1496	oxidoreductase activity
HEP81_RS28310	COG1799	cell septum assembly
HEP81_RS28325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEP81_RS28335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEP81_RS28345	COG2153	protein acetylation
HEP81_RS28390	COG0587	DNA-directed DNA polymerase activity
HEP81_RS28440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP81_RS28445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP81_RS28450	COG0131	Imidazoleglycerol-phosphate dehydratase
HEP81_RS28460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP81_RS28465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEP81_RS28470	COG0251	oxidation-reduction process
HEP81_RS28475	COG0107	imidazoleglycerol-phosphate synthase activity
HEP81_RS28490	COG0346	lactoylglutathione lyase activity
HEP81_RS28500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP81_RS28525	COG0134	indole-3-glycerol-phosphate synthase activity
HEP81_RS28535	COG0133	tryptophan synthase activity
HEP81_RS28540	COG0159	tryptophan synthase activity
HEP81_RS28550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HEP81_RS28560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS28565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP81_RS28595	COG0069	glutamate synthase activity
HEP81_RS28595	COG0070	glutamate synthase
HEP81_RS28595	COG0067	glutamate synthase
HEP81_RS28615	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS28620	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS28625	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS28630	COG1309	transcriptional regulator
HEP81_RS28655	COG1024	Enoyl-CoA hydratase
HEP81_RS28665	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS28685	COG0287	Prephenate dehydrogenase
HEP81_RS28685	COG1605	Chorismate mutase
HEP81_RS28750	COG0683	leucine binding
HEP81_RS28755	COG2050	protein possibly involved in aromatic compounds catabolism
HEP81_RS28790	COG1643	Atp-dependent helicase
HEP81_RS28795	COG2226	methyltransferase
HEP81_RS28800	COG0539	negative regulation of cytoplasmic translation
HEP81_RS28815	COG0237	dephospho-CoA kinase activity
HEP81_RS28830	COG2226	methyltransferase
HEP81_RS28910	COG0598	Magnesium transport protein CorA
HEP81_RS28915	COG2226	methyltransferase
HEP81_RS28920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HEP81_RS28920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HEP81_RS28925	COG2313	pseudouridylate synthase activity
HEP81_RS28930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP81_RS28935	COG0584	glycerophosphoryl diester phosphodiesterase
HEP81_RS28945	COG0556	nucleotide-excision repair
HEP81_RS28965	COG0387	Pfam Sodium calcium exchanger
HEP81_RS28970	COG0477	Major facilitator Superfamily
HEP81_RS28975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP81_RS28980	COG1126	abc transporter atp-binding protein
HEP81_RS28985	COG0765	amino acid transport
HEP81_RS28990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP81_RS29005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP81_RS29015	COG1609	Transcriptional regulator
HEP81_RS29030	COG0322	excinuclease ABC activity
HEP81_RS29035	COG1660	Displays ATPase and GTPase activities
HEP81_RS29045	COG1481	regulation of sporulation
HEP81_RS29050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP81_RS29055	COG0126	phosphoglycerate kinase activity
HEP81_RS29060	COG0149	triose-phosphate isomerase activity
HEP81_RS29065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEP81_RS29080	COG0166	Belongs to the GPI family
HEP81_RS29090	COG0363	glucosamine-6-phosphate deaminase activity
HEP81_RS29105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP81_RS29115	COG0109	protoheme IX farnesyltransferase activity
HEP81_RS29140	COG1131	(ABC) transporter
HEP81_RS29145	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP81_RS29160	COG0719	Fe-S assembly protein
HEP81_RS29170	COG0396	ATPase activity
HEP81_RS29175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP81_RS29180	COG0822	iron-sulfur transferase activity
HEP81_RS29195	COG3226	Transcriptional regulator
HEP81_RS29200	COG2171	N-acyltransferase activity
HEP81_RS29210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP81_RS29270	COG0395	ABC-type sugar transport system, permease component
HEP81_RS29275	COG1175	transmembrane transport
HEP81_RS29285	COG1349	DNA-binding transcription factor activity
HEP81_RS29320	COG1414	Transcriptional regulator
HEP81_RS29335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP81_RS29340	COG5285	phytanoyl-CoA dioxygenase
HEP81_RS29345	COG1917	Cupin 2, conserved barrel domain protein
HEP81_RS29350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP81_RS29355	COG0456	acetyltransferase
HEP81_RS29360	COG2318	DinB family
HEP81_RS29365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP81_RS29375	COG0765	amino acid transport
HEP81_RS29400	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HEP81_RS29435	COG1797	cobyrinic acid a,c-diamide synthase activity
HEP81_RS29455	COG1492	cobalamin metabolic process
HEP81_RS29460	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEP81_RS29480	COG0235	Class ii aldolase
HEP81_RS29500	COG0488	(ABC) transporter
HEP81_RS29510	COG1024	Enoyl-CoA hydratase
HEP81_RS29520	COG1302	Protein conserved in bacteria
HEP81_RS29550	COG3387	PFAM Glycoside hydrolase 15-related
HEP81_RS29565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP81_RS29575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS29580	COG1404	Belongs to the peptidase S8 family
HEP81_RS29590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP81_RS29595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP81_RS29615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP81_RS29660	COG2186	Transcriptional regulator
HEP81_RS29675	COG0588	phosphoglycerate mutase activity
HEP81_RS29680	COG0560	Phosphoserine phosphatase
HEP81_RS29680	COG3830	Belongs to the UPF0237 family
HEP81_RS29685	COG0842	Transport permease protein
HEP81_RS29685	COG1131	(ABC) transporter
HEP81_RS29685	COG1716	ATPase activity
HEP81_RS29695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP81_RS29700	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS29705	COG4585	Histidine kinase
HEP81_RS29710	COG2197	response regulator
HEP81_RS29725	COG1119	ATPase activity
HEP81_RS29745	COG1881	PFAM PEBP family protein
HEP81_RS29755	COG2094	Belongs to the DNA glycosylase MPG family
HEP81_RS29785	COG0647	UMP catabolic process
HEP81_RS29790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP81_RS29795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP81_RS29800	COG1120	ATPase activity
HEP81_RS29820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP81_RS29825	COG0497	DNA recombination
HEP81_RS29850	COG3387	PFAM Glycoside hydrolase 15-related
HEP81_RS29855	COG0504	CTP synthase activity
HEP81_RS29860	COG0494	nUDIX hydrolase
HEP81_RS29870	COG0686	Belongs to the AlaDH PNT family
HEP81_RS29885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HEP81_RS29890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP81_RS29895	COG1187	pseudouridine synthase activity
HEP81_RS29930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP81_RS29940	COG1160	GTP binding
HEP81_RS29955	COG1652	LysM domain
HEP81_RS29960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP81_RS29970	COG0671	phosphoesterase, PA-phosphatase related
HEP81_RS29980	COG0477	Major facilitator Superfamily
HEP81_RS29985	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS29990	COG1799	cell septum assembly
HEP81_RS30000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP81_RS30005	COG0765	amino acid transport
HEP81_RS30015	COG1126	abc transporter atp-binding protein
HEP81_RS30040	COG0587	DNA-directed DNA polymerase activity
HEP81_RS30060	COG2264	protein methyltransferase activity
HEP81_RS30075	COG1725	Transcriptional regulator
HEP81_RS30100	COG0726	polysaccharide deacetylase
HEP81_RS30100	COG1649	PFAM Uncharacterised BCR, COG1649
HEP81_RS30105	COG1216	Glycosyl transferase, family 2
HEP81_RS30120	COG2755	lipolytic protein G-D-S-L family
HEP81_RS30130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS30140	COG2188	Transcriptional regulator
HEP81_RS30145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP81_RS30155	COG1309	transcriptional regulator
HEP81_RS30160	COG0243	molybdopterin cofactor binding
HEP81_RS30185	COG0640	Transcriptional regulator
HEP81_RS30195	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS30250	COG3876	Protein conserved in bacteria
HEP81_RS30260	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS30280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP81_RS30310	COG3265	gluconokinase activity
HEP81_RS30315	COG2186	Transcriptional regulator
HEP81_RS30320	COG3012	SEC-C Motif Domain Protein
HEP81_RS30335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEP81_RS30335	COG1796	DNA polymerase
HEP81_RS30375	COG0667	Aldo Keto reductase
HEP81_RS30380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP81_RS30385	COG0598	Magnesium transport protein CorA
HEP81_RS30390	COG0406	alpha-ribazole phosphatase activity
HEP81_RS30405	COG0215	cysteine-tRNA ligase activity
HEP81_RS30415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP81_RS30420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP81_RS30425	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP81_RS30430	COG1414	Transcriptional regulator
HEP81_RS30435	COG0646	methionine synthase
HEP81_RS30435	COG1410	methionine synthase
HEP81_RS30445	COG0747	negative chemotaxis
HEP81_RS30450	COG2197	response regulator
HEP81_RS30460	COG0517	IMP dehydrogenase activity
HEP81_RS30460	COG1994	Peptidase M50
HEP81_RS30480	COG1222	aaa ATPase
HEP81_RS30485	COG4122	O-methyltransferase activity
HEP81_RS30500	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP81_RS30505	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP81_RS30510	COG1609	Transcriptional regulator
HEP81_RS30520	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP81_RS30525	COG0545	Peptidyl-prolyl cis-trans isomerase
HEP81_RS30555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP81_RS30560	COG0805	protein transport
HEP81_RS30595	COG0564	pseudouridine synthase activity
HEP81_RS30615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP81_RS30620	COG4175	Glycine betaine
HEP81_RS30620	COG0517	IMP dehydrogenase activity
HEP81_RS30625	COG4176	ABC-type proline glycine betaine transport system permease component
HEP81_RS30635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEP81_RS30650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP81_RS30655	COG2186	Transcriptional regulator
HEP81_RS30660	COG0174	glutamine synthetase
HEP81_RS30665	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS30700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP81_RS30705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEP81_RS30710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP81_RS30715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP81_RS30720	COG5002	protein histidine kinase activity
HEP81_RS30725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP81_RS30730	COG0072	phenylalanine-tRNA ligase activity
HEP81_RS30730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP81_RS30760	COG1649	PFAM Uncharacterised BCR, COG1649
HEP81_RS30795	COG0463	Glycosyl transferase, family 2
HEP81_RS30820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP81_RS30825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEP81_RS30830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP81_RS30835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP81_RS30840	COG1438	arginine binding
HEP81_RS30855	COG1132	(ABC) transporter
HEP81_RS30880	COG0745	RESPONSE REGULATOR receiver
HEP81_RS30885	COG2205	protein histidine kinase activity
HEP81_RS30900	COG0137	argininosuccinate synthase activity
HEP81_RS30905	COG0165	Argininosuccinate lyase
HEP81_RS30920	COG0477	Major facilitator Superfamily
HEP81_RS30925	COG2132	Multicopper oxidase
HEP81_RS30955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP81_RS30960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP81_RS30965	COG2011	ABC-type metal ion transport system permease component
HEP81_RS30970	COG1464	Belongs to the NlpA lipoprotein family
HEP81_RS30985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEP81_RS30990	COG1648	precorrin-2 dehydrogenase activity
HEP81_RS30990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP81_RS31040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP81_RS31105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEP81_RS31120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEP81_RS31140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP81_RS31145	COG1560	Kdo2-lipid A biosynthetic process
HEP81_RS31150	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS31160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HEP81_RS31165	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HEP81_RS31170	COG0217	transcriptional regulatory protein
HEP81_RS31175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEP81_RS31180	COG0632	four-way junction helicase activity
HEP81_RS31185	COG2255	four-way junction helicase activity
HEP81_RS31195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP81_RS31200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP81_RS31205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEP81_RS31210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP81_RS31215	COG1196	nuclear chromosome segregation
HEP81_RS31220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP81_RS31230	COG0124	histidyl-tRNA synthetase
HEP81_RS31245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP81_RS31265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP81_RS31270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP81_RS31275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP81_RS31280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEP81_RS31285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEP81_RS31290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP81_RS31295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEP81_RS31305	COG0006	proline dipeptidase activity
HEP81_RS31310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP81_RS31315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP81_RS31325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEP81_RS31330	COG0540	Belongs to the ATCase OTCase family
HEP81_RS31335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP81_RS31345	COG0505	Belongs to the CarA family
HEP81_RS31350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP81_RS31355	COG0167	dihydroorotate dehydrogenase activity
HEP81_RS31360	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP81_RS31370	COG0194	GDP metabolic process
HEP81_RS31385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP81_RS31390	COG0539	negative regulation of cytoplasmic translation
HEP81_RS31405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP81_RS31420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEP81_RS31425	COG2390	Transcriptional regulator
HEP81_RS31440	COG3629	intracellular signal transduction
HEP81_RS31440	COG3903	Transcriptional regulator
HEP81_RS31460	COG0531	amino acid
HEP81_RS31470	COG2188	Transcriptional regulator
HEP81_RS31480	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP81_RS31490	COG3842	ATPase activity
HEP81_RS31495	COG0546	phosphoglycolate phosphatase activity
HEP81_RS31520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP81_RS31540	COG2233	PERMEase
HEP81_RS31550	COG0738	Major facilitator superfamily
HEP81_RS31570	COG3201	nicotinamide mononucleotide transporter
HEP81_RS31575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP81_RS31575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP81_RS31580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP81_RS31585	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP81_RS31590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP81_RS31645	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS31670	COG1216	Glycosyl transferase, family 2
HEP81_RS31685	COG2270	Major facilitator Superfamily
HEP81_RS31695	COG2364	Membrane
HEP81_RS31730	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS31740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP81_RS31745	COG1984	allophanate hydrolase subunit 2
HEP81_RS31750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEP81_RS31755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HEP81_RS31760	COG4336	lyase activity
HEP81_RS31765	COG2814	Major facilitator Superfamily
HEP81_RS31790	COG1414	Transcriptional regulator
HEP81_RS31805	COG2018	Roadblock/LC7 domain
HEP81_RS31855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP81_RS31865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP81_RS31895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP81_RS31915	COG1716	ATPase activity
HEP81_RS31935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP81_RS31945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP81_RS31945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP81_RS32020	COG0509	glycine decarboxylation via glycine cleavage system
HEP81_RS32050	COG0697	spore germination
HEP81_RS32065	COG0697	spore germination
HEP81_RS32105	COG0747	negative chemotaxis
HEP81_RS32110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP81_RS32125	COG2318	DinB family
HEP81_RS32140	COG0673	inositol 2-dehydrogenase activity
HEP81_RS32145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEP81_RS32170	COG0183	Belongs to the thiolase family
HEP81_RS32190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP81_RS32215	COG0604	alcohol dehydrogenase
HEP81_RS32215	COG3321	synthase
HEP81_RS32230	COG0596	Alpha beta hydrolase
HEP81_RS32235	COG1819	glycosyl
HEP81_RS32260	COG0110	maltose O-acetyltransferase activity
HEP81_RS32285	COG0640	Transcriptional regulator
HEP81_RS32290	COG0531	amino acid
HEP81_RS32295	COG1832	CoA-binding protein
HEP81_RS32310	COG1739	Uncharacterized protein family UPF0029
HEP81_RS32315	COG0420	3'-5' exonuclease activity
HEP81_RS32320	COG0419	ATPase involved in DNA repair
HEP81_RS32355	COG0626	cystathionine gamma-synthase activity
HEP81_RS32380	COG2267	carboxylic ester hydrolase activity
HEP81_RS32390	COG1595	DNA-templated transcription, initiation
HEP81_RS32395	COG2188	Transcriptional regulator
HEP81_RS32405	COG1940	carbohydrate kinase activity
HEP81_RS32410	COG2197	response regulator
HEP81_RS32415	COG4585	Histidine kinase
HEP81_RS32435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEP81_RS32580	COG0305	Participates in initiation and elongation during chromosome replication
HEP81_RS32635	COG0456	acetyltransferase
HEP81_RS32665	COG2226	methyltransferase
HEP81_RS32670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP81_RS32675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP81_RS32680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP81_RS32715	COG0740	serine-type endopeptidase activity
HEP81_RS32725	COG0831	urea catabolic process
HEP81_RS32730	COG0832	Belongs to the urease beta subunit family
HEP81_RS32735	COG0804	urea catabolic process
HEP81_RS32745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP81_RS32750	COG0829	nickel cation binding
HEP81_RS32755	COG0204	Acyl-transferase
HEP81_RS32765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP81_RS32770	COG1834	amidinotransferase
HEP81_RS32775	COG1522	sequence-specific DNA binding
HEP81_RS32790	COG0205	6-phosphofructokinase activity
HEP81_RS32795	COG3442	glutamine amidotransferase
HEP81_RS32805	COG0242	peptide deformylase activity
HEP81_RS32815	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS32825	COG2124	cytochrome p450
HEP81_RS32830	COG3424	synthase
HEP81_RS32850	COG1793	dna ligase
HEP81_RS32865	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS32870	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS32905	COG0586	Pfam SNARE associated Golgi protein
HEP81_RS32985	COG0464	growth
HEP81_RS33000	COG2197	response regulator
HEP81_RS33010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP81_RS33015	COG2423	ornithine cyclodeaminase activity
HEP81_RS33070	COG3959	Transketolase, thiamine diphosphate binding domain
HEP81_RS33080	COG0443	Heat shock 70 kDa protein
HEP81_RS33090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS33095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS33095	COG3321	synthase
HEP81_RS33095	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS33095	COG0300	oxidoreductase activity
HEP81_RS33095	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS33100	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS33105	COG3251	PFAM MbtH domain protein
HEP81_RS33110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS33140	COG2264	protein methyltransferase activity
HEP81_RS33145	COG0477	Major facilitator Superfamily
HEP81_RS33170	COG0367	asparagine synthase
HEP81_RS33180	COG2986	histidine ammonia-lyase
HEP81_RS33185	COG2197	response regulator
HEP81_RS33195	COG4865	methylaspartate mutase activity
HEP81_RS33215	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HEP81_RS33225	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS33230	COG0662	Cupin 2, conserved barrel domain protein
HEP81_RS33240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS33250	COG0512	Glutamine amidotransferase of anthranilate synthase
HEP81_RS33250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP81_RS33260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP81_RS33335	COG0714	Associated with various cellular activities
HEP81_RS33355	COG0583	DNA-binding transcription factor activity
HEP81_RS33360	COG1408	metallophosphoesterase
HEP81_RS33385	COG1278	Cold shock
HEP81_RS33415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEP81_RS33440	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS33450	COG0475	glutathione-regulated potassium exporter activity
HEP81_RS33460	COG0477	Major facilitator Superfamily
HEP81_RS33485	COG1012	belongs to the aldehyde dehydrogenase family
HEP81_RS33510	COG1940	carbohydrate kinase activity
HEP81_RS33560	COG2018	Roadblock/LC7 domain
HEP81_RS33570	COG1946	Acyl-CoA thioesterase
HEP81_RS33585	COG0254	rRNA binding
HEP81_RS33595	COG1132	(ABC) transporter
HEP81_RS33630	COG1132	(ABC) transporter
HEP81_RS33640	COG2072	flavoprotein involved in K transport
HEP81_RS33645	COG0432	Pfam Uncharacterised protein family UPF0047
HEP81_RS33655	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP81_RS33670	COG0477	Major facilitator Superfamily
HEP81_RS33675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP81_RS33690	COG2706	6-phosphogluconolactonase activity
HEP81_RS33705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP81_RS33725	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS33740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP81_RS33745	COG1902	pentaerythritol trinitrate reductase activity
HEP81_RS33750	COG0640	Transcriptional regulator
HEP81_RS33765	COG1309	transcriptional regulator
HEP81_RS33785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP81_RS33820	COG0584	glycerophosphoryl diester phosphodiesterase
HEP81_RS33870	COG2086	electron transfer activity
HEP81_RS33875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEP81_RS33900	COG3345	alpha-galactosidase
HEP81_RS33920	COG1660	Displays ATPase and GTPase activities
HEP81_RS33925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP81_RS33935	COG0445	tRNA wobble uridine modification
HEP81_RS33960	COG0180	Tryptophanyl-tRNA synthetase
HEP81_RS34015	COG1595	DNA-templated transcription, initiation
HEP81_RS34025	COG1349	DNA-binding transcription factor activity
HEP81_RS34040	COG2813	Specifically methylates the guanine in position
HEP81_RS34060	COG1940	carbohydrate kinase activity
HEP81_RS34105	COG1349	DNA-binding transcription factor activity
HEP81_RS34150	COG1215	transferase activity, transferring glycosyl groups
HEP81_RS34180	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS34205	COG4106	trans-aconitate 2-methyltransferase activity
HEP81_RS34240	COG3469	chitinase activity
HEP81_RS34250	COG1309	transcriptional regulator
HEP81_RS34255	COG2409	Drug exporters of the RND superfamily
HEP81_RS34260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP81_RS34275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP81_RS34290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP81_RS34325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP81_RS34330	COG1993	acr, cog1993
HEP81_RS34335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP81_RS34340	COG1968	undecaprenyl-diphosphatase activity
HEP81_RS34360	COG2066	Belongs to the glutaminase family
HEP81_RS34375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP81_RS34390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP81_RS34395	COG3458	cephalosporin-C deacetylase activity
HEP81_RS34410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP81_RS34425	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP81_RS34450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP81_RS34450	COG1902	pentaerythritol trinitrate reductase activity
HEP81_RS34465	COG4733	cellulase activity
HEP81_RS34465	COG5297	Belongs to the glycosyl hydrolase family 6
HEP81_RS34475	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HEP81_RS34480	COG1461	Dihydroxyacetone kinase
HEP81_RS34485	COG2376	Dihydroxyacetone kinase
HEP81_RS34525	COG0464	growth
HEP81_RS34545	COG1674	ftsk spoiiie
HEP81_RS34570	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS34595	COG0656	L-ascorbic acid biosynthetic process
HEP81_RS34605	COG0583	DNA-binding transcription factor activity
HEP81_RS34615	COG0443	Heat shock 70 kDa protein
HEP81_RS34620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP81_RS34625	COG0484	heat shock protein binding
HEP81_RS34635	COG0542	response to heat
HEP81_RS34655	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS34660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP81_RS34665	COG4989	oxidoreductase activity
HEP81_RS34675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP81_RS34680	COG0561	phosphatase activity
HEP81_RS34685	COG0494	nUDIX hydrolase
HEP81_RS34700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEP81_RS34725	COG1131	(ABC) transporter
HEP81_RS34730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP81_RS34735	COG0662	Cupin 2, conserved barrel domain protein
HEP81_RS34740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEP81_RS34750	COG2070	2-Nitropropane dioxygenase
HEP81_RS34760	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS34785	COG1024	Enoyl-CoA hydratase
HEP81_RS34825	COG0510	thiamine kinase activity
HEP81_RS34845	COG3511	phospholipase C
HEP81_RS34850	COG0673	inositol 2-dehydrogenase activity
HEP81_RS34860	COG0367	asparagine synthase
HEP81_RS34905	COG3250	beta-galactosidase activity
HEP81_RS34910	COG0531	amino acid
HEP81_RS34940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP81_RS34950	COG0583	DNA-binding transcription factor activity
HEP81_RS34955	COG0667	Aldo Keto reductase
HEP81_RS34980	COG1191	sigma factor activity
HEP81_RS35005	COG0328	RNA-DNA hybrid ribonuclease activity
HEP81_RS35010	COG0667	Aldo Keto reductase
HEP81_RS35080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP81_RS35120	COG5002	protein histidine kinase activity
HEP81_RS35170	COG1252	NADH dehydrogenase
HEP81_RS35185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEP81_RS35190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP81_RS35195	COG3281	Trehalose synthase
HEP81_RS35205	COG0366	Alpha amylase catalytic
HEP81_RS35245	COG0842	Transport permease protein
HEP81_RS35255	COG0181	hydroxymethylbilane synthase activity
HEP81_RS35260	COG1793	dna ligase
HEP81_RS35285	COG2208	phosphoserine phosphatase activity
HEP81_RS35300	COG0656	L-ascorbic acid biosynthetic process
HEP81_RS35320	COG0596	Alpha beta hydrolase
HEP81_RS35345	COG0009	L-threonylcarbamoyladenylate synthase
HEP81_RS35365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP81_RS35390	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP81_RS35395	COG0673	inositol 2-dehydrogenase activity
HEP81_RS35470	COG1921	L-seryl-tRNASec selenium transferase activity
HEP81_RS35500	COG0437	4 iron, 4 sulfur cluster binding
HEP81_RS35520	COG0477	Major facilitator Superfamily
HEP81_RS35525	COG0586	Pfam SNARE associated Golgi protein
HEP81_RS35535	COG0667	Aldo Keto reductase
HEP81_RS35585	COG0438	transferase activity, transferring glycosyl groups
HEP81_RS35595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP81_RS35600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP81_RS35640	COG0628	permease
HEP81_RS35650	COG1285	pathogenesis
HEP81_RS35660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP81_RS35660	COG1024	Enoyl-CoA hydratase
HEP81_RS35665	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEP81_RS35670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP81_RS35675	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEP81_RS35680	COG0298	carbon dioxide binding
HEP81_RS35695	COG0375	protein maturation
HEP81_RS35720	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEP81_RS35760	COG0701	Predicted permease
HEP81_RS35775	COG0589	response to stress
HEP81_RS35780	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HEP81_RS35795	COG0517	IMP dehydrogenase activity
HEP81_RS35795	COG0516	GMP reductase activity
HEP81_RS35810	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEP81_RS35845	COG2801	Transposase and inactivated derivatives
HEP81_RS35845	COG3415	Transposase
HEP81_RS35880	COG0640	Transcriptional regulator
HEP81_RS35885	COG1316	TRANSCRIPTIONal
HEP81_RS35900	COG1090	epimerase
HEP81_RS35905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP81_RS35910	COG2409	Drug exporters of the RND superfamily
HEP81_RS35930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP81_RS35940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP81_RS35965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP81_RS35980	COG0745	RESPONSE REGULATOR receiver
HEP81_RS35985	COG5002	protein histidine kinase activity
HEP81_RS36000	COG0768	penicillin binding
HEP81_RS36005	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS36005	COG2172	sigma factor antagonist activity
HEP81_RS36005	COG2208	phosphoserine phosphatase activity
HEP81_RS36025	COG2080	2 iron, 2 sulfur cluster binding
HEP81_RS36030	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP81_RS36035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP81_RS36055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP81_RS36070	COG2755	lipolytic protein G-D-S-L family
HEP81_RS36075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP81_RS36100	COG1584	GPR1 FUN34 yaaH family protein
HEP81_RS36130	COG4585	Histidine kinase
HEP81_RS36135	COG2197	response regulator
HEP81_RS36145	COG0583	DNA-binding transcription factor activity
HEP81_RS36175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HEP81_RS36175	COG0517	IMP dehydrogenase activity
HEP81_RS36175	COG0617	tRNA 3'-terminal CCA addition
HEP81_RS36185	COG1228	amidohydrolase
HEP81_RS36250	COG2755	lipolytic protein G-D-S-L family
HEP81_RS36275	COG3979	chitinase
HEP81_RS36285	COG1177	transmembrane transport
HEP81_RS36290	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP81_RS36295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP81_RS36300	COG3842	ATPase activity
HEP81_RS36320	COG1132	(ABC) transporter
HEP81_RS36350	COG0277	FAD linked oxidase domain protein
HEP81_RS36355	COG1597	lipid kinase activity
HEP81_RS36370	COG2837	iron assimilation
HEP81_RS36375	COG0542	response to heat
HEP81_RS36380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP81_RS36410	COG1396	sequence-specific DNA binding
HEP81_RS36485	COG1131	(ABC) transporter
HEP81_RS36555	COG2132	Multicopper oxidase
HEP81_RS36560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS36560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP81_RS36560	COG1703	isobutyryl-CoA mutase activity
HEP81_RS36580	COG0604	alcohol dehydrogenase
HEP81_RS36585	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEP81_RS36585	COG0778	Nitroreductase
HEP81_RS36590	COG2226	methyltransferase
HEP81_RS36615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEP81_RS36640	COG4585	Histidine kinase
HEP81_RS36650	COG3415	Transposase
HEP81_RS36650	COG2801	Transposase and inactivated derivatives
HEP81_RS36680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEP81_RS36720	COG0477	Major facilitator Superfamily
HEP81_RS36745	COG0110	maltose O-acetyltransferase activity
HEP81_RS36755	COG0517	IMP dehydrogenase activity
HEP81_RS36855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP81_RS36860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP81_RS36865	COG4948	Mandelate Racemase Muconate Lactonizing
HEP81_RS36885	COG3896	Chloramphenicol phosphotransferase-like protein
HEP81_RS36930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP81_RS36935	COG0405	Gamma-glutamyltransferase
HEP81_RS36940	COG1609	Transcriptional regulator
HEP81_RS36950	COG1879	ABC-type sugar transport system periplasmic component
HEP81_RS36955	COG1129	ABC transporter
HEP81_RS36960	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP81_RS36970	COG1609	Transcriptional regulator
HEP81_RS36990	COG4977	sequence-specific DNA binding
HEP81_RS37005	COG1136	(ABC) transporter
HEP81_RS37010	COG0577	efflux transmembrane transporter activity
HEP81_RS37045	COG1278	Cold shock
HEP81_RS37055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP81_RS37070	COG0640	Transcriptional regulator
HEP81_RS37075	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS37075	COG3321	synthase
HEP81_RS37075	COG0604	alcohol dehydrogenase
HEP81_RS37120	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP81_RS37140	COG2801	Transposase and inactivated derivatives
HEP81_RS37140	COG3415	Transposase
HEP81_RS37165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP81_RS37195	COG2814	Major facilitator Superfamily
HEP81_RS37205	COG4260	virion core protein, lumpy skin disease virus
HEP81_RS37215	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEP81_RS37275	COG0702	epimerase
HEP81_RS37280	COG1846	Transcriptional regulator
HEP81_RS37285	COG2409	Drug exporters of the RND superfamily
HEP81_RS37295	COG0789	Transcriptional regulator
HEP81_RS37300	COG3046	protein related to deoxyribodipyrimidine photolyase
HEP81_RS37315	COG0076	glutamate decarboxylase activity
HEP81_RS37355	COG0702	epimerase
HEP81_RS37360	COG3631	Ketosteroid isomerase-related protein
HEP81_RS37415	COG0702	epimerase
HEP81_RS37420	COG1733	regulation of RNA biosynthetic process
HEP81_RS37425	COG1418	mRNA catabolic process
HEP81_RS37435	COG0277	FAD linked oxidase domain protein
HEP81_RS37440	COG1309	transcriptional regulator
HEP81_RS37465	COG1175	transmembrane transport
HEP81_RS37470	COG0395	ABC-type sugar transport system, permease component
HEP81_RS37475	COG0366	Alpha amylase catalytic
HEP81_RS37485	COG2124	cytochrome p450
HEP81_RS37505	COG3251	PFAM MbtH domain protein
HEP81_RS37515	COG2814	Major facilitator Superfamily
HEP81_RS37560	COG0604	alcohol dehydrogenase
HEP81_RS37560	COG3321	synthase
HEP81_RS37580	COG0604	alcohol dehydrogenase
HEP81_RS37590	COG2124	cytochrome p450
HEP81_RS37600	COG3629	intracellular signal transduction
HEP81_RS37640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEP81_RS37650	COG0667	Aldo Keto reductase
HEP81_RS37670	COG1309	transcriptional regulator
HEP81_RS37710	COG0395	ABC-type sugar transport system, permease component
HEP81_RS37715	COG1175	transmembrane transport
HEP81_RS37725	COG1609	Transcriptional regulator
HEP81_RS37790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP81_RS37795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP81_RS37810	COG1595	DNA-templated transcription, initiation
HEP81_RS37855	COG1349	DNA-binding transcription factor activity
HEP81_RS37885	COG3979	chitinase
HEP81_RS37895	COG0583	DNA-binding transcription factor activity
HEP81_RS37905	COG1960	acyl-CoA dehydrogenase activity
HEP81_RS37910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS37915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP81_RS37925	COG4977	sequence-specific DNA binding
HEP81_RS37950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP81_RS38040	COG1191	sigma factor activity
HEP81_RS38095	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HEP81_RS38110	COG0009	L-threonylcarbamoyladenylate synthase
HEP81_RS38130	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS38135	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP81_RS38140	COG2172	sigma factor antagonist activity
HEP81_RS38160	COG1295	ribonuclease BN
HEP81_RS38175	COG0028	Belongs to the TPP enzyme family
HEP81_RS38180	COG0069	glutamate synthase activity
HEP81_RS38195	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS38200	COG1959	2 iron, 2 sulfur cluster binding
HEP81_RS38210	COG1733	regulation of RNA biosynthetic process
HEP81_RS38215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP81_RS38230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP81_RS38260	COG0275	rRNA processing
HEP81_RS38295	COG0535	radical SAM domain protein
HEP81_RS38300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEP81_RS38305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP81_RS38340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS38365	COG1349	DNA-binding transcription factor activity
HEP81_RS38370	COG1105	Belongs to the carbohydrate kinase PfkB family
HEP81_RS38375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP81_RS38375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP81_RS38375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP81_RS38445	COG3851	Histidine kinase
HEP81_RS38450	COG2197	response regulator
HEP81_RS38515	COG0604	alcohol dehydrogenase
HEP81_RS38550	COG2197	response regulator
HEP81_RS38615	COG2197	response regulator
HEP81_RS38620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP81_RS38635	COG1309	transcriptional regulator
HEP81_RS38655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP81_RS38665	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEP81_RS38680	COG0142	geranyltranstransferase activity
HEP81_RS38715	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS38725	COG2801	Transposase and inactivated derivatives
HEP81_RS38765	COG0604	alcohol dehydrogenase
HEP81_RS38765	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS38765	COG3321	synthase
HEP81_RS38770	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP81_RS38775	COG1846	Transcriptional regulator
HEP81_RS38785	COG4191	Histidine kinase
HEP81_RS38795	COG0667	Aldo Keto reductase
HEP81_RS38800	COG1309	transcriptional regulator
HEP81_RS38835	COG4977	sequence-specific DNA binding
HEP81_RS38845	COG0702	epimerase
HEP81_RS38930	COG3547	Transposase (IS116 IS110 IS902 family)
HEP81_RS38980	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS38995	COG2124	cytochrome p450
HEP81_RS39000	COG0477	Major facilitator Superfamily
HEP81_RS39005	COG2271	Major facilitator Superfamily
HEP81_RS39025	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP81_RS39110	COG0583	DNA-binding transcription factor activity
HEP81_RS39130	COG4251	negative regulation of phosphorylation
HEP81_RS39140	COG0784	Response regulator, receiver
HEP81_RS39150	COG0142	geranyltranstransferase activity
HEP81_RS39155	COG1119	ATPase activity
HEP81_RS39165	COG1024	Enoyl-CoA hydratase
HEP81_RS39170	COG2124	cytochrome p450
HEP81_RS39245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEP81_RS39260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HEP81_RS39270	COG0488	(ABC) transporter
HEP81_RS39275	COG0488	(ABC) transporter
HEP81_RS39290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS39290	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS39290	COG3321	synthase
HEP81_RS39290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP81_RS39295	COG1231	oxidoreductase activity
HEP81_RS39305	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP81_RS39305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS39305	COG3321	synthase
HEP81_RS39305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP81_RS39310	COG4221	oxidoreductase activity
HEP81_RS39310	COG3321	synthase
HEP81_RS39310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS39310	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39315	COG3321	synthase
HEP81_RS39315	COG0300	oxidoreductase activity
HEP81_RS39315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS39315	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS39315	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39325	COG2814	Major facilitator Superfamily
HEP81_RS39355	COG2124	cytochrome p450
HEP81_RS39370	COG0667	Aldo Keto reductase
HEP81_RS39375	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP81_RS39380	COG1819	glycosyl
HEP81_RS39385	COG2124	cytochrome p450
HEP81_RS39440	COG2124	cytochrome p450
HEP81_RS39480	COG0488	(ABC) transporter
HEP81_RS39490	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEP81_RS39495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEP81_RS39505	COG0646	methionine synthase
HEP81_RS39505	COG1410	methionine synthase
HEP81_RS39510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP81_RS39515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP81_RS39570	COG0318	PFAM AMP-dependent synthetase and ligase
HEP81_RS39590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP81_RS39595	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HEP81_RS39610	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39610	COG3321	synthase
HEP81_RS39610	COG4221	oxidoreductase activity
HEP81_RS39610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP81_RS39630	COG0022	dehydrogenase e1 component
HEP81_RS39635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP81_RS39640	COG1309	transcriptional regulator
HEP81_RS39650	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39695	COG2755	lipolytic protein G-D-S-L family
HEP81_RS39695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP81_RS39700	COG0477	Major facilitator Superfamily
HEP81_RS39740	COG1192	Involved in chromosome partitioning
HEP81_RS39785	COG0142	geranyltranstransferase activity
HEP81_RS39800	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEP81_RS39810	COG1959	2 iron, 2 sulfur cluster binding
HEP81_RS39815	COG1028	Short-chain dehydrogenase reductase Sdr
HEP81_RS39845	COG0657	acetylesterase activity
HEP81_RS39945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP81_RS40070	COG1660	Displays ATPase and GTPase activities
HEP81_RS40110	COG1660	Displays ATPase and GTPase activities
HEP81_RS40190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP81_RS40190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP81_RS40280	COG1051	belongs to the nudix hydrolase family
HEP81_RS40465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP81_RS40530	COG0515	serine threonine protein kinase
HEP81_RS40570	COG2186	Transcriptional regulator
HEP81_RS40730	COG1475	DNA binding
HEP81_RS40755	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD