locus-tag	class	description
DWG14_RS00015	COG3958	Transketolase
DWG14_RS00020	COG3959	Transketolase, thiamine diphosphate binding domain
DWG14_RS00055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DWG14_RS00065	COG0183	Belongs to the thiolase family
DWG14_RS00070	COG0583	DNA-binding transcription factor activity
DWG14_RS00085	COG1309	transcriptional regulator
DWG14_RS00115	COG1454	alcohol dehydrogenase
DWG14_RS00120	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS00140	COG1309	transcriptional regulator
DWG14_RS00170	COG2508	Transcriptional regulator
DWG14_RS00180	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS00210	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS00235	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWG14_RS00285	COG3971	2-oxopent-4-enoate hydratase activity
DWG14_RS00290	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS00560	COG2205	protein histidine kinase activity
DWG14_RS00565	COG0745	RESPONSE REGULATOR receiver
DWG14_RS00590	COG2205	protein histidine kinase activity
DWG14_RS00595	COG0745	RESPONSE REGULATOR receiver
DWG14_RS00600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DWG14_RS00660	COG5002	protein histidine kinase activity
DWG14_RS00665	COG2018	Roadblock/LC7 domain
DWG14_RS00745	COG1113	amino acid transport
DWG14_RS00800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWG14_RS00800	COG1672	PFAM Archaeal ATPase
DWG14_RS00850	COG1733	regulation of RNA biosynthetic process
DWG14_RS00875	COG2205	protein histidine kinase activity
DWG14_RS00880	COG0745	RESPONSE REGULATOR receiver
DWG14_RS00900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWG14_RS00925	COG0745	RESPONSE REGULATOR receiver
DWG14_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS01000	COG3250	beta-galactosidase activity
DWG14_RS01005	COG0395	ABC-type sugar transport system, permease component
DWG14_RS01040	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS01045	COG1454	alcohol dehydrogenase
DWG14_RS01080	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS01155	COG0477	Major facilitator Superfamily
DWG14_RS01195	COG2186	Transcriptional regulator
DWG14_RS01270	COG1309	transcriptional regulator
DWG14_RS01275	COG1021	2,3-dihydroxybenzoate-AMP ligase
DWG14_RS01295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS01300	COG0601	transmembrane transport
DWG14_RS01305	COG4166	transmembrane transport
DWG14_RS01310	COG0154	amidase activity
DWG14_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS01335	COG2814	Major facilitator Superfamily
DWG14_RS01385	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DWG14_RS01390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DWG14_RS01415	COG4221	oxidoreductase activity
DWG14_RS01425	COG0583	DNA-binding transcription factor activity
DWG14_RS01430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWG14_RS01445	COG0574	Belongs to the PEP-utilizing enzyme family
DWG14_RS01445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWG14_RS01460	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DWG14_RS01495	COG0516	GMP reductase activity
DWG14_RS01495	COG0517	IMP dehydrogenase activity
DWG14_RS01500	COG0409	Hydrogenase expression formation protein
DWG14_RS01505	COG0309	Hydrogenase expression formation protein (HypE)
DWG14_RS01520	COG0516	GMP reductase activity
DWG14_RS01520	COG0517	IMP dehydrogenase activity
DWG14_RS01550	COG0549	Belongs to the carbamate kinase family
DWG14_RS01580	COG0516	GMP reductase activity
DWG14_RS01580	COG0517	IMP dehydrogenase activity
DWG14_RS01595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWG14_RS01615	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DWG14_RS01645	COG0205	6-phosphofructokinase activity
DWG14_RS01670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWG14_RS01700	COG3415	Transposase
DWG14_RS01700	COG2801	Transposase and inactivated derivatives
DWG14_RS01735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWG14_RS01745	COG0640	Transcriptional regulator
DWG14_RS01750	COG2226	methyltransferase
DWG14_RS01760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWG14_RS01770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWG14_RS01780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DWG14_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS01810	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWG14_RS01825	COG4689	acetoacetate decarboxylase
DWG14_RS01840	COG0174	glutamine synthetase
DWG14_RS01860	COG4191	Histidine kinase
DWG14_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS01880	COG0583	DNA-binding transcription factor activity
DWG14_RS01890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DWG14_RS01895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DWG14_RS01900	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DWG14_RS01930	COG0596	Alpha beta hydrolase
DWG14_RS01940	COG4221	oxidoreductase activity
DWG14_RS02080	COG1819	glycosyl
DWG14_RS02130	COG1414	Transcriptional regulator
DWG14_RS02145	COG1126	abc transporter atp-binding protein
DWG14_RS02150	COG2040	homocysteine
DWG14_RS02165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS02175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS02190	COG0747	negative chemotaxis
DWG14_RS02200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS02205	COG4172	Belongs to the ABC transporter superfamily
DWG14_RS02210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS02240	COG3693	PFAM glycoside hydrolase, family 10
DWG14_RS02250	COG1506	peptidase
DWG14_RS02250	COG0823	Involved in the tonB-independent uptake of proteins
DWG14_RS02255	COG3507	Belongs to the glycosyl hydrolase 43 family
DWG14_RS02295	COG1609	Transcriptional regulator
DWG14_RS02305	COG1024	Enoyl-CoA hydratase
DWG14_RS02315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWG14_RS02315	COG0574	Belongs to the PEP-utilizing enzyme family
DWG14_RS02320	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS02355	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWG14_RS02360	COG0022	dehydrogenase e1 component
DWG14_RS02365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DWG14_RS02375	COG4638	Rieske (2fe-2S)
DWG14_RS02395	COG2130	NADP-dependent
DWG14_RS02425	COG1129	ABC transporter
DWG14_RS02435	COG1063	alcohol dehydrogenase
DWG14_RS02450	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS02465	COG0183	Belongs to the thiolase family
DWG14_RS02485	COG2186	Transcriptional regulator
DWG14_RS02495	COG0515	serine threonine protein kinase
DWG14_RS02500	COG0477	Major facilitator Superfamily
DWG14_RS02515	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWG14_RS02520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS02525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWG14_RS02545	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS02550	COG0039	L-malate dehydrogenase activity
DWG14_RS02560	COG1414	Transcriptional regulator
DWG14_RS02565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWG14_RS02580	COG1137	ATPase activity
DWG14_RS02625	COG2124	cytochrome p450
DWG14_RS02635	COG1414	Transcriptional regulator
DWG14_RS02650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWG14_RS02660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWG14_RS02665	COG1126	abc transporter atp-binding protein
DWG14_RS02670	COG0765	amino acid transport
DWG14_RS02675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWG14_RS02685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWG14_RS02695	COG0473	3-isopropylmalate dehydrogenase activity
DWG14_RS02700	COG0583	DNA-binding transcription factor activity
DWG14_RS02705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWG14_RS02735	COG2326	polyphosphate kinase activity
DWG14_RS02740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWG14_RS02745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS02810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWG14_RS02835	COG3629	intracellular signal transduction
DWG14_RS02835	COG3903	Transcriptional regulator
DWG14_RS02840	COG2124	cytochrome p450
DWG14_RS02935	COG3321	synthase
DWG14_RS02935	COG0604	alcohol dehydrogenase
DWG14_RS02965	COG0745	RESPONSE REGULATOR receiver
DWG14_RS02970	COG5002	protein histidine kinase activity
DWG14_RS02975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWG14_RS02990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWG14_RS03000	COG4935	Belongs to the peptidase S8 family
DWG14_RS03000	COG2234	aminopeptidase activity
DWG14_RS03015	COG1136	(ABC) transporter
DWG14_RS03015	COG0577	efflux transmembrane transporter activity
DWG14_RS03020	COG1136	(ABC) transporter
DWG14_RS03020	COG0577	efflux transmembrane transporter activity
DWG14_RS03025	COG0254	rRNA binding
DWG14_RS03030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWG14_RS03070	COG1472	Belongs to the glycosyl hydrolase 3 family
DWG14_RS03085	COG1175	transmembrane transport
DWG14_RS03120	COG1295	ribonuclease BN
DWG14_RS03125	COG1278	Cold shock
DWG14_RS03150	COG4585	Histidine kinase
DWG14_RS03180	COG2860	membrane
DWG14_RS03185	COG2223	nitrite transmembrane transporter activity
DWG14_RS03190	COG2207	Transcriptional regulator
DWG14_RS03200	COG1725	Transcriptional regulator
DWG14_RS03205	COG1131	(ABC) transporter
DWG14_RS03260	COG0726	polysaccharide deacetylase
DWG14_RS03290	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DWG14_RS03345	COG2226	methyltransferase
DWG14_RS03360	COG4249	Peptidase C14 caspase catalytic subunit p20
DWG14_RS03360	COG2319	Wd-40 repeat
DWG14_RS03405	COG1802	Transcriptional regulator
DWG14_RS03410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS03440	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWG14_RS03445	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWG14_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS03470	COG0583	DNA-binding transcription factor activity
DWG14_RS03490	COG2124	cytochrome p450
DWG14_RS03495	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS03500	COG2124	cytochrome p450
DWG14_RS03505	COG0477	Major facilitator Superfamily
DWG14_RS03510	COG0596	Alpha beta hydrolase
DWG14_RS03525	COG0402	S-adenosylhomocysteine deaminase activity
DWG14_RS03540	COG2207	Transcriptional regulator
DWG14_RS03545	COG1063	alcohol dehydrogenase
DWG14_RS03550	COG0477	Major facilitator Superfamily
DWG14_RS03575	COG5297	Belongs to the glycosyl hydrolase family 6
DWG14_RS03580	COG5297	Belongs to the glycosyl hydrolase family 6
DWG14_RS03580	COG4733	cellulase activity
DWG14_RS03695	COG3345	alpha-galactosidase
DWG14_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS03750	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
DWG14_RS03785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DWG14_RS03800	COG2205	protein histidine kinase activity
DWG14_RS03805	COG0745	RESPONSE REGULATOR receiver
DWG14_RS03810	COG0671	phosphoesterase, PA-phosphatase related
DWG14_RS03815	COG0671	phosphoesterase, PA-phosphatase related
DWG14_RS03835	COG1295	ribonuclease BN
DWG14_RS03840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWG14_RS03845	COG2151	metal-sulfur cluster biosynthetic enzyme
DWG14_RS03850	COG3396	Phenylacetate-CoA oxygenase
DWG14_RS03855	COG3460	Phenylacetate-CoA oxygenase
DWG14_RS03860	COG3396	Phenylacetate-CoA oxygenase
DWG14_RS03865	COG0183	Belongs to the thiolase family
DWG14_RS03875	COG3848	Pyruvate phosphate dikinase
DWG14_RS03875	COG0574	Belongs to the PEP-utilizing enzyme family
DWG14_RS03890	COG0546	phosphoglycolate phosphatase activity
DWG14_RS03895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWG14_RS03905	COG2208	phosphoserine phosphatase activity
DWG14_RS03905	COG2770	Histidine kinase
DWG14_RS03910	COG0596	Alpha beta hydrolase
DWG14_RS03925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DWG14_RS03945	COG0142	geranyltranstransferase activity
DWG14_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWG14_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS04015	COG3046	protein related to deoxyribodipyrimidine photolyase
DWG14_RS04025	COG2045	Belongs to the ComB family
DWG14_RS04030	COG1136	(ABC) transporter
DWG14_RS04030	COG0577	efflux transmembrane transporter activity
DWG14_RS04035	COG1136	(ABC) transporter
DWG14_RS04050	COG0745	RESPONSE REGULATOR receiver
DWG14_RS04055	COG5002	protein histidine kinase activity
DWG14_RS04090	COG4977	sequence-specific DNA binding
DWG14_RS04130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS04155	COG1473	amidohydrolase
DWG14_RS04190	COG0640	Transcriptional regulator
DWG14_RS04205	COG3290	protein histidine kinase activity
DWG14_RS04220	COG1846	Transcriptional regulator
DWG14_RS04245	COG2755	lipolytic protein G-D-S-L family
DWG14_RS04275	COG2080	2 iron, 2 sulfur cluster binding
DWG14_RS04280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DWG14_RS04285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWG14_RS04365	COG0667	Aldo Keto reductase
DWG14_RS04370	COG0673	inositol 2-dehydrogenase activity
DWG14_RS04395	COG2409	Drug exporters of the RND superfamily
DWG14_RS04425	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWG14_RS04430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWG14_RS04460	COG1072	(Pantothenic acid kinase))
DWG14_RS04490	COG0395	ABC-type sugar transport system, permease component
DWG14_RS04505	COG1940	carbohydrate kinase activity
DWG14_RS04560	COG1309	transcriptional regulator
DWG14_RS04580	COG1309	transcriptional regulator
DWG14_RS04590	COG2072	flavoprotein involved in K transport
DWG14_RS04605	COG1940	carbohydrate kinase activity
DWG14_RS04605	COG1846	Transcriptional regulator
DWG14_RS04660	COG1132	(ABC) transporter
DWG14_RS04685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWG14_RS04720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DWG14_RS04740	COG0517	IMP dehydrogenase activity
DWG14_RS04750	COG0515	serine threonine protein kinase
DWG14_RS04760	COG1132	(ABC) transporter
DWG14_RS04765	COG1132	(ABC) transporter
DWG14_RS04770	COG2197	response regulator
DWG14_RS04810	COG3832	glyoxalase III activity
DWG14_RS04825	COG0248	Ppx GppA phosphatase
DWG14_RS04840	COG2890	protein-(glutamine-N5) methyltransferase activity
DWG14_RS04890	COG1595	DNA-templated transcription, initiation
DWG14_RS04895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DWG14_RS04925	COG4977	sequence-specific DNA binding
DWG14_RS04925	COG1917	Cupin 2, conserved barrel domain protein
DWG14_RS04935	COG0667	Aldo Keto reductase
DWG14_RS04955	COG2124	cytochrome p450
DWG14_RS04975	COG0435	Glutathione S-transferase
DWG14_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS05030	COG1846	Transcriptional regulator
DWG14_RS05050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS05055	COG1006	Multisubunit Na H antiporter MnhC subunit
DWG14_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS05100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DWG14_RS05100	COG1796	DNA polymerase
DWG14_RS05105	COG0546	phosphoglycolate phosphatase activity
DWG14_RS05135	COG1940	carbohydrate kinase activity
DWG14_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS05200	COG2706	6-phosphogluconolactonase activity
DWG14_RS05210	COG1309	transcriptional regulator
DWG14_RS05220	COG1357	PFAM Pentapeptide repeats (8 copies)
DWG14_RS05235	COG1609	Transcriptional regulator
DWG14_RS05250	COG1879	ABC-type sugar transport system periplasmic component
DWG14_RS05255	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS05260	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS05265	COG1129	ABC transporter
DWG14_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS05275	COG3347	Dehydrogenase
DWG14_RS05280	COG1070	Carbohydrate kinase
DWG14_RS05285	COG0247	lactate metabolic process
DWG14_RS05290	COG1139	Iron-sulfur cluster binding protein
DWG14_RS05295	COG1556	Lactate utilization protein
DWG14_RS05300	COG3250	beta-galactosidase activity
DWG14_RS05305	COG3940	Belongs to the glycosyl hydrolase 43 family
DWG14_RS05310	COG2755	lipolytic protein G-D-S-L family
DWG14_RS05330	COG0542	response to heat
DWG14_RS05375	COG1609	Transcriptional regulator
DWG14_RS05380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWG14_RS05385	COG0697	spore germination
DWG14_RS05400	COG2186	Transcriptional regulator
DWG14_RS05415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWG14_RS05435	COG2197	response regulator
DWG14_RS05455	COG1120	ATPase activity
DWG14_RS05460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWG14_RS05470	COG1301	dicarboxylic acid transport
DWG14_RS05475	COG2828	Protein conserved in bacteria
DWG14_RS05550	COG0242	peptide deformylase activity
DWG14_RS05560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWG14_RS05575	COG1609	Transcriptional regulator
DWG14_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS05660	COG2197	response regulator
DWG14_RS05665	COG1252	NADH dehydrogenase
DWG14_RS05675	COG2353	YceI-like domain
DWG14_RS05680	COG1454	alcohol dehydrogenase
DWG14_RS05685	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS05695	COG3284	Transcriptional regulator
DWG14_RS05705	COG1595	DNA-templated transcription, initiation
DWG14_RS05760	COG1609	Transcriptional regulator
DWG14_RS05765	COG0281	malic enzyme
DWG14_RS05800	COG0640	Transcriptional regulator
DWG14_RS05810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DWG14_RS05815	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS05820	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWG14_RS05860	COG3940	Belongs to the glycosyl hydrolase 43 family
DWG14_RS05875	COG2268	Band 7 protein
DWG14_RS05890	COG3572	ergothioneine biosynthetic process
DWG14_RS05895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DWG14_RS05900	COG0121	glutamine amidotransferase
DWG14_RS05905	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DWG14_RS05915	COG3360	Dodecin
DWG14_RS05940	COG0523	cobalamin synthesis protein
DWG14_RS05950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS05970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWG14_RS05975	COG1053	succinate dehydrogenase
DWG14_RS05985	COG0583	DNA-binding transcription factor activity
DWG14_RS06035	COG0726	polysaccharide deacetylase
DWG14_RS06055	COG2267	carboxylic ester hydrolase activity
DWG14_RS06085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWG14_RS06100	COG3618	amidohydrolase
DWG14_RS06115	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS06120	COG4948	Mandelate Racemase Muconate Lactonizing
DWG14_RS06130	COG1129	ABC transporter
DWG14_RS06135	COG1879	ABC-type sugar transport system periplasmic component
DWG14_RS06140	COG2186	Transcriptional regulator
DWG14_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS06190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DWG14_RS06195	COG0297	glycogen (starch) synthase activity
DWG14_RS06215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DWG14_RS06225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWG14_RS06245	COG0542	response to heat
DWG14_RS06255	COG0484	heat shock protein binding
DWG14_RS06260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWG14_RS06265	COG0443	Heat shock 70 kDa protein
DWG14_RS06320	COG0668	transmembrane transport
DWG14_RS06330	COG2838	Isocitrate dehydrogenase
DWG14_RS06355	COG1404	Belongs to the peptidase S8 family
DWG14_RS06365	COG2197	response regulator
DWG14_RS06430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS06435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS06450	COG1126	abc transporter atp-binding protein
DWG14_RS06460	COG0435	Glutathione S-transferase
DWG14_RS06465	COG0129	dihydroxy-acid dehydratase activity
DWG14_RS06470	COG1063	alcohol dehydrogenase
DWG14_RS06475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWG14_RS06485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWG14_RS06500	COG1215	transferase activity, transferring glycosyl groups
DWG14_RS06510	COG4310	Domain of unknown function (DUF2172)
DWG14_RS06525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWG14_RS06535	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS06580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DWG14_RS06585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DWG14_RS06590	COG1132	(ABC) transporter
DWG14_RS06620	COG1597	lipid kinase activity
DWG14_RS06680	COG0477	Major facilitator Superfamily
DWG14_RS06700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DWG14_RS06705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWG14_RS06730	COG1609	Transcriptional regulator
DWG14_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS06755	COG0673	inositol 2-dehydrogenase activity
DWG14_RS06775	COG0673	inositol 2-dehydrogenase activity
DWG14_RS06805	COG3962	Belongs to the TPP enzyme family
DWG14_RS06810	COG2188	Transcriptional regulator
DWG14_RS06815	COG3387	PFAM Glycoside hydrolase 15-related
DWG14_RS06845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWG14_RS06865	COG0489	protein tyrosine kinase activity
DWG14_RS06880	COG1316	TRANSCRIPTIONal
DWG14_RS06885	COG1086	Polysaccharide biosynthesis protein
DWG14_RS06900	COG0494	nUDIX hydrolase
DWG14_RS06960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DWG14_RS06970	COG0174	glutamine synthetase
DWG14_RS07020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWG14_RS07045	COG0583	DNA-binding transcription factor activity
DWG14_RS07050	COG0156	8-amino-7-oxononanoate synthase activity
DWG14_RS07055	COG1063	alcohol dehydrogenase
DWG14_RS07105	COG2755	lipolytic protein G-D-S-L family
DWG14_RS07115	COG4942	peptidase
DWG14_RS07125	COG2365	Tyrosine phosphatase family
DWG14_RS07145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWG14_RS07150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWG14_RS07165	COG1657	PFAM Prenyltransferase squalene oxidase
DWG14_RS07175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWG14_RS07185	COG1562	ergosterol biosynthetic process
DWG14_RS07190	COG1134	teichoic acid transport
DWG14_RS07235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DWG14_RS07255	COG1024	Enoyl-CoA hydratase
DWG14_RS07265	COG4977	sequence-specific DNA binding
DWG14_RS07275	COG2183	response to ionizing radiation
DWG14_RS07285	COG0488	(ABC) transporter
DWG14_RS07295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWG14_RS07300	COG2936	dipeptidyl-peptidase activity
DWG14_RS07315	COG1113	amino acid transport
DWG14_RS07320	COG0789	Transcriptional regulator
DWG14_RS07325	COG1024	Enoyl-CoA hydratase
DWG14_RS07325	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWG14_RS07330	COG0183	Belongs to the thiolase family
DWG14_RS07335	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS07340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS07345	COG3268	Saccharopine dehydrogenase
DWG14_RS07350	COG1515	deoxyribonuclease V activity
DWG14_RS07380	COG0488	(ABC) transporter
DWG14_RS07385	COG1834	amidinotransferase
DWG14_RS07485	COG1793	dna ligase
DWG14_RS07515	COG0183	Belongs to the thiolase family
DWG14_RS07520	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS07525	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS07535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWG14_RS07545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWG14_RS07545	COG1672	PFAM Archaeal ATPase
DWG14_RS07575	COG3511	phospholipase C
DWG14_RS07580	COG0477	Major facilitator Superfamily
DWG14_RS07600	COG1940	carbohydrate kinase activity
DWG14_RS07605	COG0395	ABC-type sugar transport system, permease component
DWG14_RS07610	COG1175	transmembrane transport
DWG14_RS07645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWG14_RS07650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWG14_RS07665	COG0366	Alpha amylase catalytic
DWG14_RS07670	COG0395	ABC-type sugar transport system, permease component
DWG14_RS07675	COG1175	transmembrane transport
DWG14_RS07720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DWG14_RS07730	COG3469	chitinase activity
DWG14_RS07745	COG1486	melibiose metabolic process
DWG14_RS07785	COG3250	beta-galactosidase activity
DWG14_RS07790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DWG14_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS07830	COG3850	Histidine kinase
DWG14_RS07835	COG2197	response regulator
DWG14_RS07845	COG2409	Drug exporters of the RND superfamily
DWG14_RS07855	COG3507	Belongs to the glycosyl hydrolase 43 family
DWG14_RS07855	COG2382	esterase
DWG14_RS07855	COG3693	PFAM glycoside hydrolase, family 10
DWG14_RS07870	COG3511	phospholipase C
DWG14_RS07885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWG14_RS07900	COG0166	Belongs to the GPI family
DWG14_RS07905	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DWG14_RS07910	COG0588	phosphoglycerate mutase activity
DWG14_RS07920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWG14_RS07930	COG0477	Major facilitator Superfamily
DWG14_RS07935	COG0346	lactoylglutathione lyase activity
DWG14_RS07940	COG3467	pyridoxamine 5'-phosphate
DWG14_RS07970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWG14_RS07990	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS08015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS08020	COG0747	negative chemotaxis
DWG14_RS08040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWG14_RS08045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS08055	COG1595	DNA-templated transcription, initiation
DWG14_RS08065	COG1160	GTP binding
DWG14_RS08120	COG0443	Heat shock 70 kDa protein
DWG14_RS08145	COG0515	serine threonine protein kinase
DWG14_RS08145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWG14_RS08150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWG14_RS08165	COG0210	DNA helicase
DWG14_RS08190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS08195	COG0028	Belongs to the TPP enzyme family
DWG14_RS08200	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS08205	COG0583	DNA-binding transcription factor activity
DWG14_RS08215	COG3383	formate dehydrogenase (NAD+) activity
DWG14_RS08240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS08255	COG0045	succinate-CoA ligase (ADP-forming) activity
DWG14_RS08260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS08265	COG2223	nitrite transmembrane transporter activity
DWG14_RS08280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWG14_RS08285	COG0243	molybdopterin cofactor binding
DWG14_RS08320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DWG14_RS08335	COG0673	inositol 2-dehydrogenase activity
DWG14_RS08345	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS08350	COG1129	ABC transporter
DWG14_RS08355	COG1940	carbohydrate kinase activity
DWG14_RS08360	COG0702	epimerase
DWG14_RS08370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWG14_RS08380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DWG14_RS08385	COG1335	isochorismatase
DWG14_RS08420	COG0477	Major facilitator Superfamily
DWG14_RS08430	COG3250	beta-galactosidase activity
DWG14_RS08435	COG3469	chitinase activity
DWG14_RS08475	COG5297	Belongs to the glycosyl hydrolase family 6
DWG14_RS08485	COG4733	cellulase activity
DWG14_RS08485	COG5297	Belongs to the glycosyl hydrolase family 6
DWG14_RS08505	COG2378	regulation of single-species biofilm formation
DWG14_RS08520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWG14_RS08525	COG2154	pterin-4-alpha-carbinolamine dehydratase
DWG14_RS08550	COG0443	Heat shock 70 kDa protein
DWG14_RS08615	COG0028	Belongs to the TPP enzyme family
DWG14_RS08625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DWG14_RS08625	COG0517	IMP dehydrogenase activity
DWG14_RS08655	COG0488	(ABC) transporter
DWG14_RS08660	COG2226	methyltransferase
DWG14_RS08720	COG3285	dna ligase
DWG14_RS08720	COG1793	dna ligase
DWG14_RS08735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS08745	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS08785	COG1619	proteins homologs of microcin C7 resistance protein MccF
DWG14_RS08795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWG14_RS08800	COG2362	D-Aminopeptidase
DWG14_RS08805	COG3594	Acyltransferase
DWG14_RS08810	COG2226	methyltransferase
DWG14_RS08840	COG0251	oxidation-reduction process
DWG14_RS08855	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWG14_RS08865	COG0604	alcohol dehydrogenase
DWG14_RS08870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS08870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS08885	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS08890	COG0688	phosphatidylethanolamine metabolic process
DWG14_RS08930	COG1929	Belongs to the glycerate kinase type-1 family
DWG14_RS08940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWG14_RS08960	COG0640	Transcriptional regulator
DWG14_RS08975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DWG14_RS08985	COG0483	inositol monophosphate 1-phosphatase activity
DWG14_RS09000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWG14_RS09005	COG2197	response regulator
DWG14_RS09025	COG1953	Uracil, thiamine, allantoin
DWG14_RS09035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWG14_RS09050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWG14_RS09075	COG0542	response to heat
DWG14_RS09080	COG0405	Gamma-glutamyltransferase
DWG14_RS09090	COG2936	dipeptidyl-peptidase activity
DWG14_RS09095	COG1126	abc transporter atp-binding protein
DWG14_RS09115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWG14_RS09120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWG14_RS09130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWG14_RS09140	COG1940	carbohydrate kinase activity
DWG14_RS09145	COG2188	Transcriptional regulator
DWG14_RS09150	COG0673	inositol 2-dehydrogenase activity
DWG14_RS09160	COG2197	response regulator
DWG14_RS09165	COG4585	Histidine kinase
DWG14_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS09180	COG4266	Belongs to the allantoicase family
DWG14_RS09185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWG14_RS09190	COG1414	Transcriptional regulator
DWG14_RS09200	COG0746	molybdenum cofactor guanylyltransferase activity
DWG14_RS09205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DWG14_RS09225	COG0515	serine threonine protein kinase
DWG14_RS09225	COG2815	serine threonine protein kinase
DWG14_RS09260	COG4264	IucA IucC family
DWG14_RS09275	COG1733	regulation of RNA biosynthetic process
DWG14_RS09280	COG0436	Aminotransferase
DWG14_RS09295	COG0406	alpha-ribazole phosphatase activity
DWG14_RS09325	COG2233	PERMEase
DWG14_RS09340	COG2351	hydroxyisourate hydrolase activity
DWG14_RS09360	COG3622	Belongs to the hyi family
DWG14_RS09365	COG2084	Dehydrogenase
DWG14_RS09370	COG3960	tartronate-semialdehyde synthase activity
DWG14_RS09380	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS09385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWG14_RS09390	COG2197	response regulator
DWG14_RS09435	COG1404	Belongs to the peptidase S8 family
DWG14_RS09460	COG2205	protein histidine kinase activity
DWG14_RS09465	COG0745	RESPONSE REGULATOR receiver
DWG14_RS09505	COG0076	glutamate decarboxylase activity
DWG14_RS09545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS09615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DWG14_RS09635	COG2252	PERMEase
DWG14_RS09640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWG14_RS09655	COG3835	regulator
DWG14_RS09665	COG1802	Transcriptional regulator
DWG14_RS09700	COG0028	Belongs to the TPP enzyme family
DWG14_RS09735	COG1162	GTPase activity
DWG14_RS09745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWG14_RS09760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS09765	COG3938	Belongs to the proline racemase family
DWG14_RS09775	COG5297	Belongs to the glycosyl hydrolase family 6
DWG14_RS09790	COG0277	FAD linked oxidase domain protein
DWG14_RS09810	COG1175	transmembrane transport
DWG14_RS09815	COG0395	ABC-type sugar transport system, permease component
DWG14_RS09825	COG1131	(ABC) transporter
DWG14_RS09850	COG0596	Alpha beta hydrolase
DWG14_RS09865	COG2755	lipolytic protein G-D-S-L family
DWG14_RS09890	COG2040	homocysteine
DWG14_RS09910	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS09920	COG3321	synthase
DWG14_RS09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWG14_RS09930	COG2409	Drug exporters of the RND superfamily
DWG14_RS09945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWG14_RS09950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWG14_RS09970	COG1609	Transcriptional regulator
DWG14_RS10010	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS10040	COG0175	sulfate reduction
DWG14_RS10045	COG0529	Catalyzes the synthesis of activated sulfate
DWG14_RS10070	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DWG14_RS10085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWG14_RS10100	COG2409	Drug exporters of the RND superfamily
DWG14_RS10110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWG14_RS10125	COG1175	transmembrane transport
DWG14_RS10135	COG0583	DNA-binding transcription factor activity
DWG14_RS10205	COG3173	Aminoglycoside phosphotransferase
DWG14_RS10215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWG14_RS10230	COG3629	intracellular signal transduction
DWG14_RS10230	COG3903	Transcriptional regulator
DWG14_RS10245	COG1309	transcriptional regulator
DWG14_RS10260	COG1404	Belongs to the peptidase S8 family
DWG14_RS10285	COG3340	Belongs to the peptidase S51 family
DWG14_RS10320	COG5002	protein histidine kinase activity
DWG14_RS10325	COG2018	Roadblock/LC7 domain
DWG14_RS10340	COG1174	glycine betaine transport
DWG14_RS10345	COG1174	glycine betaine transport
DWG14_RS10355	COG1477	protein flavinylation
DWG14_RS10365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWG14_RS10365	COG1017	nitric oxide dioxygenase activity
DWG14_RS10370	COG0745	RESPONSE REGULATOR receiver
DWG14_RS10375	COG2205	protein histidine kinase activity
DWG14_RS10380	COG3883	PFAM NLP P60 protein
DWG14_RS10380	COG0791	NLP P60 protein
DWG14_RS10385	COG1595	DNA-templated transcription, initiation
DWG14_RS10395	COG3903	Transcriptional regulator
DWG14_RS10395	COG3629	intracellular signal transduction
DWG14_RS10420	COG4821	SIS domain
DWG14_RS10425	COG1737	Transcriptional regulator
DWG14_RS10445	COG1175	transmembrane transport
DWG14_RS10450	COG0395	ABC-type sugar transport system, permease component
DWG14_RS10455	COG1472	Belongs to the glycosyl hydrolase 3 family
DWG14_RS10470	COG1472	Belongs to the glycosyl hydrolase 3 family
DWG14_RS10475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWG14_RS10480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWG14_RS10515	COG0330	HflC and HflK could
DWG14_RS10525	COG2326	polyphosphate kinase activity
DWG14_RS10530	COG0723	plastoquinol--plastocyanin reductase activity
DWG14_RS10530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWG14_RS10550	COG3220	belongs to the UPF0276 family
DWG14_RS10570	COG3253	May function as heme-dependent peroxidase
DWG14_RS10585	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWG14_RS10600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DWG14_RS10615	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DWG14_RS10625	COG1175	transmembrane transport
DWG14_RS10635	COG3250	beta-galactosidase activity
DWG14_RS10640	COG1609	Transcriptional regulator
DWG14_RS10645	COG0183	Belongs to the thiolase family
DWG14_RS10650	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWG14_RS10650	COG1024	Enoyl-CoA hydratase
DWG14_RS10665	COG0531	amino acid
DWG14_RS10670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWG14_RS10675	COG4214	carbohydrate transport
DWG14_RS10685	COG4213	ABC transporter substrate-binding protein
DWG14_RS10690	COG1940	carbohydrate kinase activity
DWG14_RS10695	COG0395	ABC-type sugar transport system, permease component
DWG14_RS10700	COG1175	transmembrane transport
DWG14_RS10705	COG1653	transport
DWG14_RS10735	COG0395	ABC-type sugar transport system, permease component
DWG14_RS10740	COG4209	transmembrane transport
DWG14_RS10745	COG3458	cephalosporin-C deacetylase activity
DWG14_RS10765	COG2205	protein histidine kinase activity
DWG14_RS10770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DWG14_RS10785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWG14_RS10855	COG1024	Enoyl-CoA hydratase
DWG14_RS10865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWG14_RS10870	COG2235	arginine
DWG14_RS10885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DWG14_RS10915	COG1799	cell septum assembly
DWG14_RS10935	COG0277	FAD linked oxidase domain protein
DWG14_RS10935	COG0247	lactate metabolic process
DWG14_RS10960	COG0243	molybdopterin cofactor binding
DWG14_RS10975	COG0436	Aminotransferase
DWG14_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS11000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWG14_RS11005	COG0531	amino acid
DWG14_RS11010	COG0569	domain protein
DWG14_RS11040	COG1136	(ABC) transporter
DWG14_RS11040	COG4591	ABC-type transport system involved in lipoprotein release permease component
DWG14_RS11055	COG0756	dUTP diphosphatase activity
DWG14_RS11080	COG2205	protein histidine kinase activity
DWG14_RS11085	COG0745	RESPONSE REGULATOR receiver
DWG14_RS11095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWG14_RS11125	COG1435	thymidine kinase activity
DWG14_RS11140	COG0045	succinate-CoA ligase (ADP-forming) activity
DWG14_RS11140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWG14_RS11140	COG1042	CoA-binding domain protein
DWG14_RS11150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWG14_RS11155	COG1802	Transcriptional regulator
DWG14_RS11160	COG0739	heme binding
DWG14_RS11170	COG0612	Peptidase, M16
DWG14_RS11175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWG14_RS11180	COG0523	cobalamin synthesis protein
DWG14_RS11195	COG0372	Belongs to the citrate synthase family
DWG14_RS11210	COG3290	protein histidine kinase activity
DWG14_RS11215	COG4565	transcriptional regulatory protein
DWG14_RS11225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWG14_RS11235	COG4565	transcriptional regulatory protein
DWG14_RS11240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS11250	COG2197	response regulator
DWG14_RS11265	COG0187	DNA topoisomerase II activity
DWG14_RS11280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWG14_RS11285	COG1802	Transcriptional regulator
DWG14_RS11325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWG14_RS11350	COG0588	phosphoglycerate mutase activity
DWG14_RS11370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWG14_RS11375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWG14_RS11380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWG14_RS11410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWG14_RS11420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWG14_RS11425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DWG14_RS11435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWG14_RS11460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWG14_RS11465	COG2197	response regulator
DWG14_RS11470	COG2843	Capsule synthesis protein
DWG14_RS11525	COG4585	Histidine kinase
DWG14_RS11530	COG2197	response regulator
DWG14_RS11535	COG0137	argininosuccinate synthase activity
DWG14_RS11555	COG2197	response regulator
DWG14_RS11560	COG4585	Histidine kinase
DWG14_RS11580	COG2358	TRAP transporter, solute receptor (TAXI family
DWG14_RS11585	COG2205	protein histidine kinase activity
DWG14_RS11590	COG0745	RESPONSE REGULATOR receiver
DWG14_RS11595	COG1126	abc transporter atp-binding protein
DWG14_RS11600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWG14_RS11605	COG0765	amino acid transport
DWG14_RS11610	COG0765	amino acid transport
DWG14_RS11630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWG14_RS11670	COG1201	RNA secondary structure unwinding
DWG14_RS11675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWG14_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS11690	COG1396	sequence-specific DNA binding
DWG14_RS11695	COG1058	Belongs to the CinA family
DWG14_RS11695	COG1546	Belongs to the CinA family
DWG14_RS11705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWG14_RS11715	COG1674	ftsk spoiiie
DWG14_RS11725	COG0784	Response regulator, receiver
DWG14_RS11725	COG2205	protein histidine kinase activity
DWG14_RS11735	COG2208	phosphoserine phosphatase activity
DWG14_RS11735	COG2770	Histidine kinase
DWG14_RS11770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWG14_RS11775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS11780	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DWG14_RS11800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWG14_RS11805	COG0612	Peptidase, M16
DWG14_RS11810	COG1185	polyribonucleotide nucleotidyltransferase activity
DWG14_RS11815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWG14_RS11825	COG1674	ftsk spoiiie
DWG14_RS11945	COG1404	Belongs to the peptidase S8 family
DWG14_RS11960	COG1404	Belongs to the peptidase S8 family
DWG14_RS11995	COG0455	bacterial-type flagellum organization
DWG14_RS12010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWG14_RS12015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWG14_RS12025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWG14_RS12040	COG0779	Required for maturation of 30S ribosomal subunits
DWG14_RS12060	COG0442	prolyl-tRNA aminoacylation
DWG14_RS12080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWG14_RS12090	COG0750	zinc metalloprotease
DWG14_RS12095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWG14_RS12120	COG1605	Chorismate mutase
DWG14_RS12145	COG0395	ABC-type sugar transport system, permease component
DWG14_RS12150	COG4209	transmembrane transport
DWG14_RS12170	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS12175	COG2508	Transcriptional regulator
DWG14_RS12200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWG14_RS12205	COG1177	transmembrane transport
DWG14_RS12215	COG3842	ATPase activity
DWG14_RS12240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWG14_RS12245	COG0584	glycerophosphoryl diester phosphodiesterase
DWG14_RS12265	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS12275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWG14_RS12310	COG3842	ATPase activity
DWG14_RS12315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DWG14_RS12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWG14_RS12330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DWG14_RS12335	COG2188	Transcriptional regulator
DWG14_RS12425	COG0575	Belongs to the CDS family
DWG14_RS12430	COG0233	cytoplasmic translational termination
DWG14_RS12435	COG0528	UMP kinase activity
DWG14_RS12440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWG14_RS12445	COG0052	Belongs to the universal ribosomal protein uS2 family
DWG14_RS12460	COG1191	sigma factor activity
DWG14_RS12475	COG0792	nuclease activity
DWG14_RS12495	COG0681	Belongs to the peptidase S26 family
DWG14_RS12510	COG0335	large ribosomal subunit rRNA binding
DWG14_RS12515	COG0336	Belongs to the RNA methyltransferase TrmD family
DWG14_RS12520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWG14_RS12525	COG1837	Belongs to the UPF0109 family
DWG14_RS12530	COG0228	four-way junction DNA binding
DWG14_RS12540	COG0442	prolyl-tRNA aminoacylation
DWG14_RS12555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DWG14_RS12590	COG0477	Major facilitator Superfamily
DWG14_RS12610	COG1254	Belongs to the acylphosphatase family
DWG14_RS12615	COG2340	Cysteine-rich secretory protein family
DWG14_RS12620	COG1733	regulation of RNA biosynthetic process
DWG14_RS12625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWG14_RS12630	COG0571	ribonuclease III activity
DWG14_RS12635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWG14_RS12650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWG14_RS12655	COG0742	ribosomal rna small subunit methyltransferase
DWG14_RS12665	COG0326	Molecular chaperone. Has ATPase activity
DWG14_RS12675	COG1461	Dihydroxyacetone kinase
DWG14_RS12680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWG14_RS12685	COG0351	phosphomethylpyrimidine kinase
DWG14_RS12705	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWG14_RS12710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWG14_RS12720	COG1920	GTP binding
DWG14_RS12730	COG0776	regulation of translation
DWG14_RS12740	COG0066	3-isopropylmalate dehydratase activity
DWG14_RS12745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWG14_RS12750	COG1414	Transcriptional regulator
DWG14_RS12790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWG14_RS12795	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWG14_RS12815	COG5002	protein histidine kinase activity
DWG14_RS12820	COG2018	Roadblock/LC7 domain
DWG14_RS12840	COG2018	Roadblock/LC7 domain
DWG14_RS12860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWG14_RS12865	COG5492	domain, Protein
DWG14_RS12905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWG14_RS12920	COG2957	Belongs to the agmatine deiminase family
DWG14_RS12925	COG0804	urea catabolic process
DWG14_RS12930	COG0832	Belongs to the urease beta subunit family
DWG14_RS12930	COG0831	urea catabolic process
DWG14_RS12935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWG14_RS12940	COG0473	3-isopropylmalate dehydrogenase activity
DWG14_RS12960	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS12965	COG0506	proline dehydrogenase activity
DWG14_RS12985	COG0477	Major facilitator Superfamily
DWG14_RS12990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWG14_RS12995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DWG14_RS13000	COG0440	acetolactate synthase activity
DWG14_RS13010	COG5001	Diguanylate cyclase
DWG14_RS13010	COG3300	MHYT domain
DWG14_RS13020	COG0667	Aldo Keto reductase
DWG14_RS13025	COG2133	pyrroloquinoline quinone binding
DWG14_RS13035	COG1672	PFAM Archaeal ATPase
DWG14_RS13035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWG14_RS13050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWG14_RS13055	COG2409	Drug exporters of the RND superfamily
DWG14_RS13065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWG14_RS13070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWG14_RS13080	COG0154	amidase activity
DWG14_RS13085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWG14_RS13095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWG14_RS13105	COG4221	oxidoreductase activity
DWG14_RS13110	COG1611	Belongs to the LOG family
DWG14_RS13130	COG4124	Belongs to the glycosyl hydrolase 26 family
DWG14_RS13130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DWG14_RS13140	COG0482	sulfurtransferase activity
DWG14_RS13150	COG2132	Multicopper oxidase
DWG14_RS13180	COG2378	regulation of single-species biofilm formation
DWG14_RS13195	COG2860	membrane
DWG14_RS13205	COG4608	Belongs to the ABC transporter superfamily
DWG14_RS13210	COG0444	Belongs to the ABC transporter superfamily
DWG14_RS13220	COG0747	negative chemotaxis
DWG14_RS13225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS13245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWG14_RS13250	COG0509	glycine decarboxylation via glycine cleavage system
DWG14_RS13255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWG14_RS13260	COG1760	l-serine dehydratase
DWG14_RS13335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWG14_RS13350	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS13355	COG3433	isochorismatase activity
DWG14_RS13355	COG1535	isochorismatase
DWG14_RS13360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWG14_RS13370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWG14_RS13375	COG1120	ATPase activity
DWG14_RS13405	COG1595	DNA-templated transcription, initiation
DWG14_RS13425	COG1595	DNA-templated transcription, initiation
DWG14_RS13455	COG1295	ribonuclease BN
DWG14_RS13470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWG14_RS13495	COG0028	Belongs to the TPP enzyme family
DWG14_RS13510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWG14_RS13525	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWG14_RS13530	COG1349	DNA-binding transcription factor activity
DWG14_RS13535	COG2223	nitrite transmembrane transporter activity
DWG14_RS13555	COG2160	L-arabinose isomerase activity
DWG14_RS13575	COG0395	ABC-type sugar transport system, permease component
DWG14_RS13610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWG14_RS13615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWG14_RS13620	COG1119	ATPase activity
DWG14_RS13670	COG2197	response regulator
DWG14_RS13675	COG4585	Histidine kinase
DWG14_RS13685	COG1131	(ABC) transporter
DWG14_RS13695	COG1132	(ABC) transporter
DWG14_RS13700	COG1132	(ABC) transporter
DWG14_RS13705	COG1132	(ABC) transporter
DWG14_RS13725	COG0058	SHG alpha-glucan phosphorylase activity
DWG14_RS13735	COG0366	Alpha amylase catalytic
DWG14_RS13740	COG0366	Alpha amylase catalytic
DWG14_RS13745	COG3281	Trehalose synthase
DWG14_RS13750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DWG14_RS13775	COG1522	sequence-specific DNA binding
DWG14_RS13795	COG1846	Transcriptional regulator
DWG14_RS13815	COG3290	protein histidine kinase activity
DWG14_RS13820	COG4565	transcriptional regulatory protein
DWG14_RS13835	COG0205	6-phosphofructokinase activity
DWG14_RS13840	COG0857	belongs to the CobB CobQ family
DWG14_RS13840	COG0280	phosphate acetyltransferase
DWG14_RS13845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWG14_RS13880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS13880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS13955	COG0745	RESPONSE REGULATOR receiver
DWG14_RS13975	COG0183	Belongs to the thiolase family
DWG14_RS13980	COG0346	lactoylglutathione lyase activity
DWG14_RS13995	COG1131	(ABC) transporter
DWG14_RS14030	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DWG14_RS14045	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWG14_RS14065	COG4585	Histidine kinase
DWG14_RS14070	COG2197	response regulator
DWG14_RS14085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DWG14_RS14090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DWG14_RS14095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWG14_RS14100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DWG14_RS14105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWG14_RS14110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWG14_RS14115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWG14_RS14135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWG14_RS14140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWG14_RS14150	COG2890	protein-(glutamine-N5) methyltransferase activity
DWG14_RS14155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWG14_RS14160	COG0254	rRNA binding
DWG14_RS14180	COG0083	homoserine kinase activity
DWG14_RS14185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWG14_RS14190	COG0460	homoserine dehydrogenase
DWG14_RS14195	COG0019	diaminopimelate decarboxylase activity
DWG14_RS14200	COG0018	arginyl-trna synthetase
DWG14_RS14305	COG2186	Transcriptional regulator
DWG14_RS14320	COG3654	unkown
DWG14_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS14350	COG1404	Belongs to the peptidase S8 family
DWG14_RS14380	COG3594	Acyltransferase
DWG14_RS14390	COG1595	DNA-templated transcription, initiation
DWG14_RS14405	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DWG14_RS14410	COG1793	dna ligase
DWG14_RS14410	COG3285	dna ligase
DWG14_RS14430	COG2205	protein histidine kinase activity
DWG14_RS14445	COG0768	penicillin binding
DWG14_RS14485	COG0791	NLP P60 protein
DWG14_RS14535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DWG14_RS14555	COG0745	RESPONSE REGULATOR receiver
DWG14_RS14560	COG2205	protein histidine kinase activity
DWG14_RS14565	COG0567	Dehydrogenase, E1 component
DWG14_RS14565	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWG14_RS14595	COG0604	alcohol dehydrogenase
DWG14_RS14600	COG0281	malic enzyme
DWG14_RS14620	COG1126	abc transporter atp-binding protein
DWG14_RS14625	COG4106	trans-aconitate 2-methyltransferase activity
DWG14_RS14645	COG2326	polyphosphate kinase activity
DWG14_RS14680	COG4941	Belongs to the sigma-70 factor family
DWG14_RS14695	COG0456	acetyltransferase
DWG14_RS14700	COG0142	geranyltranstransferase activity
DWG14_RS14705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWG14_RS14715	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DWG14_RS14745	COG1597	lipid kinase activity
DWG14_RS14760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWG14_RS14765	COG0363	glucosamine-6-phosphate deaminase activity
DWG14_RS14770	COG1472	Belongs to the glycosyl hydrolase 3 family
DWG14_RS14775	COG0395	ABC-type sugar transport system, permease component
DWG14_RS14780	COG1175	transmembrane transport
DWG14_RS14785	COG2182	Extracellular solute-binding protein
DWG14_RS14790	COG2188	Transcriptional regulator
DWG14_RS14820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWG14_RS14845	COG2124	cytochrome p450
DWG14_RS14855	COG0242	peptide deformylase activity
DWG14_RS14870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DWG14_RS14870	COG2199	diguanylate cyclase activity
DWG14_RS14895	COG5662	AntiSigma factor
DWG14_RS14900	COG1595	DNA-templated transcription, initiation
DWG14_RS14910	COG2135	peptidase activity
DWG14_RS14920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWG14_RS14925	COG1162	GTPase activity
DWG14_RS14940	COG0483	inositol monophosphate 1-phosphatase activity
DWG14_RS14970	COG1615	UPF0182 protein
DWG14_RS14980	COG3480	Lon protease (S16) C-terminal proteolytic domain
DWG14_RS15035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DWG14_RS15070	COG2226	methyltransferase
DWG14_RS15075	COG2816	NAD+ diphosphatase activity
DWG14_RS15085	COG0210	DNA helicase
DWG14_RS15155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS15160	COG0747	negative chemotaxis
DWG14_RS15200	COG0513	Belongs to the DEAD box helicase family
DWG14_RS15210	COG1432	Conserved Protein
DWG14_RS15220	COG2095	MarC family integral membrane protein
DWG14_RS15235	COG2814	Major facilitator Superfamily
DWG14_RS15245	COG0598	Magnesium transport protein CorA
DWG14_RS15285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWG14_RS15290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWG14_RS15300	COG1595	DNA-templated transcription, initiation
DWG14_RS15315	COG1024	Enoyl-CoA hydratase
DWG14_RS15320	COG2818	Glycosylase
DWG14_RS15330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DWG14_RS15340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWG14_RS15365	COG0456	acetyltransferase
DWG14_RS15375	COG2197	response regulator
DWG14_RS15380	COG4585	Histidine kinase
DWG14_RS15390	COG1131	(ABC) transporter
DWG14_RS15405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWG14_RS15420	COG4608	Belongs to the ABC transporter superfamily
DWG14_RS15430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS15435	COG0601	transmembrane transport
DWG14_RS15445	COG4608	Belongs to the ABC transporter superfamily
DWG14_RS15450	COG0444	Belongs to the ABC transporter superfamily
DWG14_RS15455	COG0601	transmembrane transport
DWG14_RS15460	COG4166	transmembrane transport
DWG14_RS15465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS15470	COG1217	gtp-binding protein TYPA
DWG14_RS15490	COG1053	succinate dehydrogenase
DWG14_RS15550	COG0583	DNA-binding transcription factor activity
DWG14_RS15555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWG14_RS15560	COG0012	GTP binding
DWG14_RS15575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DWG14_RS15585	COG1570	exodeoxyribonuclease VII activity
DWG14_RS15590	COG1722	exodeoxyribonuclease VII activity
DWG14_RS15595	COG0778	Nitroreductase
DWG14_RS15620	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DWG14_RS15620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DWG14_RS15625	COG0114	fumarate hydratase activity
DWG14_RS15640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWG14_RS15660	COG1136	(ABC) transporter
DWG14_RS15695	COG0741	lytic transglycosylase activity
DWG14_RS15700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DWG14_RS15705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWG14_RS15770	COG4585	Histidine kinase
DWG14_RS15800	COG2894	cell division
DWG14_RS15855	COG0251	oxidation-reduction process
DWG14_RS15860	COG1414	Transcriptional regulator
DWG14_RS15875	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DWG14_RS15890	COG0436	Aminotransferase
DWG14_RS15920	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DWG14_RS15930	COG0477	Major facilitator Superfamily
DWG14_RS15935	COG1309	transcriptional regulator
DWG14_RS15945	COG1331	Highly conserved protein containing a thioredoxin domain
DWG14_RS15950	COG2255	four-way junction helicase activity
DWG14_RS15960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWG14_RS15970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWG14_RS15985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWG14_RS15990	COG2255	four-way junction helicase activity
DWG14_RS16015	COG0501	Belongs to the peptidase M48B family
DWG14_RS16025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWG14_RS16055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWG14_RS16070	COG1064	alcohol dehydrogenase
DWG14_RS16085	COG1404	Belongs to the peptidase S8 family
DWG14_RS16095	COG1136	(ABC) transporter
DWG14_RS16105	COG1404	Belongs to the peptidase S8 family
DWG14_RS16130	COG2986	histidine ammonia-lyase
DWG14_RS16140	COG1024	Enoyl-CoA hydratase
DWG14_RS16150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWG14_RS16160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWG14_RS16175	COG0424	maF-like protein
DWG14_RS16185	COG4770	biotin carboxylase activity
DWG14_RS16210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWG14_RS16235	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS16240	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS16260	COG1595	DNA-templated transcription, initiation
DWG14_RS16265	COG0745	RESPONSE REGULATOR receiver
DWG14_RS16270	COG2205	protein histidine kinase activity
DWG14_RS16295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWG14_RS16305	COG0583	DNA-binding transcription factor activity
DWG14_RS16310	COG2814	Major facilitator Superfamily
DWG14_RS16345	COG1079	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS16350	COG4603	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS16355	COG3845	ABC transporter
DWG14_RS16360	COG1744	ABC transporter substrate-binding protein PnrA-like
DWG14_RS16365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWG14_RS16365	COG1473	amidohydrolase
DWG14_RS16385	COG2226	methyltransferase
DWG14_RS16425	COG2089	acid synthase
DWG14_RS16440	COG1216	Glycosyl transferase, family 2
DWG14_RS16450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DWG14_RS16470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS16470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS16485	COG1595	DNA-templated transcription, initiation
DWG14_RS16540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWG14_RS16550	COG2009	succinate dehydrogenase
DWG14_RS16560	COG1053	succinate dehydrogenase
DWG14_RS16640	COG1309	transcriptional regulator
DWG14_RS16645	COG2409	Drug exporters of the RND superfamily
DWG14_RS16650	COG0745	RESPONSE REGULATOR receiver
DWG14_RS16655	COG2205	protein histidine kinase activity
DWG14_RS16670	COG1408	metallophosphoesterase
DWG14_RS16675	COG1686	Belongs to the peptidase S11 family
DWG14_RS16680	COG1295	ribonuclease BN
DWG14_RS16710	COG0180	Tryptophanyl-tRNA synthetase
DWG14_RS16715	COG1595	DNA-templated transcription, initiation
DWG14_RS16730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWG14_RS16740	COG0754	glutathionylspermidine amidase activity
DWG14_RS16755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWG14_RS16760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWG14_RS16765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWG14_RS16785	COG4175	Glycine betaine
DWG14_RS16785	COG0517	IMP dehydrogenase activity
DWG14_RS16795	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS16840	COG0039	L-malate dehydrogenase activity
DWG14_RS16860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWG14_RS16875	COG0138	bifunctional purine biosynthesis protein purh
DWG14_RS16905	COG0045	succinate-CoA ligase (ADP-forming) activity
DWG14_RS16915	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DWG14_RS16925	COG0714	Associated with various cellular activities
DWG14_RS16940	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS16940	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS16950	COG0739	heme binding
DWG14_RS16975	COG0791	NLP P60 protein
DWG14_RS16980	COG2197	response regulator
DWG14_RS17025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWG14_RS17025	COG0519	Catalyzes the synthesis of GMP from XMP
DWG14_RS17050	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS17055	COG0515	serine threonine protein kinase
DWG14_RS17060	COG0515	serine threonine protein kinase
DWG14_RS17065	COG0515	serine threonine protein kinase
DWG14_RS17075	COG0515	serine threonine protein kinase
DWG14_RS17080	COG0515	serine threonine protein kinase
DWG14_RS17080	COG2815	serine threonine protein kinase
DWG14_RS17095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWG14_RS17110	COG0516	GMP reductase activity
DWG14_RS17120	COG1595	DNA-templated transcription, initiation
DWG14_RS17135	COG0583	DNA-binding transcription factor activity
DWG14_RS17140	COG4221	oxidoreductase activity
DWG14_RS17150	COG0459	protein refolding
DWG14_RS17155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWG14_RS17160	COG0726	polysaccharide deacetylase
DWG14_RS17165	COG0726	polysaccharide deacetylase
DWG14_RS17180	COG4941	Belongs to the sigma-70 factor family
DWG14_RS17200	COG1609	Transcriptional regulator
DWG14_RS17205	COG1472	Belongs to the glycosyl hydrolase 3 family
DWG14_RS17215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWG14_RS17235	COG0802	atpase or kinase
DWG14_RS17245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWG14_RS17265	COG0736	holo-[acyl-carrier-protein] synthase activity
DWG14_RS17305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWG14_RS17315	COG1072	(Pantothenic acid kinase))
DWG14_RS17325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWG14_RS17330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DWG14_RS17335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWG14_RS17370	COG1215	transferase activity, transferring glycosyl groups
DWG14_RS17380	COG0101	tRNA pseudouridine synthase activity
DWG14_RS17385	COG0203	ribosomal protein L17
DWG14_RS17390	COG0202	RNA polymerase activity
DWG14_RS17395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWG14_RS17400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWG14_RS17405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWG14_RS17410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWG14_RS17420	COG0563	adenylate kinase activity
DWG14_RS17430	COG0200	Binds to the 23S rRNA
DWG14_RS17435	COG1841	ribosomal large subunit assembly
DWG14_RS17440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWG14_RS17445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWG14_RS17450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWG14_RS17455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWG14_RS17465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWG14_RS17470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DWG14_RS17475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWG14_RS17480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWG14_RS17485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWG14_RS17490	COG0255	Belongs to the universal ribosomal protein uL29 family
DWG14_RS17495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWG14_RS17500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWG14_RS17505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWG14_RS17510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWG14_RS17515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWG14_RS17520	COG0089	rRNA binding
DWG14_RS17525	COG0088	Forms part of the polypeptide exit tunnel
DWG14_RS17530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWG14_RS17535	COG0051	transcription antitermination factor activity, RNA binding
DWG14_RS17560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWG14_RS17605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWG14_RS17610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWG14_RS17615	COG0049	tRNA binding
DWG14_RS17620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWG14_RS17630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWG14_RS17635	COG0085	RNA polymerase activity
DWG14_RS17645	COG0222	ribosome binding
DWG14_RS17650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWG14_RS17665	COG0081	regulation of translation
DWG14_RS17675	COG0250	Participates in transcription elongation, termination and antitermination
DWG14_RS17690	COG0436	Aminotransferase
DWG14_RS17695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWG14_RS17705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWG14_RS17710	COG0477	Major facilitator Superfamily
DWG14_RS17725	COG2030	dehydratase
DWG14_RS17730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWG14_RS17745	COG0402	S-adenosylhomocysteine deaminase activity
DWG14_RS17770	COG1666	GTP binding
DWG14_RS17775	COG2261	transglycosylase associated protein
DWG14_RS17790	COG3304	Inner membrane component domain
DWG14_RS17795	COG0501	Belongs to the peptidase M48B family
DWG14_RS17800	COG1007	ATP synthesis coupled electron transport
DWG14_RS17805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS17815	COG0713	ATP synthesis coupled electron transport
DWG14_RS17820	COG0839	Belongs to the complex I subunit 6 family
DWG14_RS17830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DWG14_RS17835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS17840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS17845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS17865	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWG14_RS17865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWG14_RS17870	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWG14_RS17885	COG1733	regulation of RNA biosynthetic process
DWG14_RS17890	COG0702	epimerase
DWG14_RS17920	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWG14_RS17930	COG1131	(ABC) transporter
DWG14_RS17940	COG0142	geranyltranstransferase activity
DWG14_RS17955	COG0561	phosphatase activity
DWG14_RS17970	COG0395	ABC-type sugar transport system, permease component
DWG14_RS17975	COG1175	transmembrane transport
DWG14_RS18000	COG0492	ferredoxin-NADP+ reductase activity
DWG14_RS18020	COG2188	Transcriptional regulator
DWG14_RS18045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DWG14_RS18050	COG0514	ATP-dependent DNA helicase (RecQ)
DWG14_RS18060	COG1007	ATP synthesis coupled electron transport
DWG14_RS18070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWG14_RS18075	COG0713	ATP synthesis coupled electron transport
DWG14_RS18085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS18090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DWG14_RS18095	COG1034	ATP synthesis coupled electron transport
DWG14_RS18100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DWG14_RS18110	COG0649	NAD binding
DWG14_RS18115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS18120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWG14_RS18135	COG0242	peptide deformylase activity
DWG14_RS18155	COG2226	methyltransferase
DWG14_RS18175	COG3979	chitinase
DWG14_RS18185	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DWG14_RS18195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWG14_RS18195	COG0515	serine threonine protein kinase
DWG14_RS18200	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DWG14_RS18205	COG1278	Cold shock
DWG14_RS18210	COG2226	methyltransferase
DWG14_RS18220	COG1053	succinate dehydrogenase
DWG14_RS18265	COG0183	Belongs to the thiolase family
DWG14_RS18270	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS18285	COG1309	transcriptional regulator
DWG14_RS18300	COG1573	uracil-dna glycosylase
DWG14_RS18305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DWG14_RS18315	COG0163	prenyltransferase activity
DWG14_RS18330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DWG14_RS18340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DWG14_RS18375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWG14_RS18380	COG1333	cytochrome c biogenesis protein
DWG14_RS18385	COG0785	Cytochrome C biogenesis protein
DWG14_RS18390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWG14_RS18400	COG0406	alpha-ribazole phosphatase activity
DWG14_RS18405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWG14_RS18420	COG0582	viral genome integration into host DNA
DWG14_RS18465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWG14_RS18480	COG0717	Belongs to the dCTP deaminase family
DWG14_RS18485	COG0297	glycogen (starch) synthase activity
DWG14_RS18495	COG1196	nuclear chromosome segregation
DWG14_RS18510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DWG14_RS18580	COG1278	Cold shock
DWG14_RS18585	COG0513	Belongs to the DEAD box helicase family
DWG14_RS18605	COG4585	Histidine kinase
DWG14_RS18610	COG2197	response regulator
DWG14_RS18640	COG0477	Major facilitator Superfamily
DWG14_RS18670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS18675	COG0604	alcohol dehydrogenase
DWG14_RS18680	COG1733	regulation of RNA biosynthetic process
DWG14_RS18690	COG1742	UPF0060 membrane protein
DWG14_RS18705	COG1690	Belongs to the RtcB family
DWG14_RS18725	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DWG14_RS18730	COG0018	arginyl-trna synthetase
DWG14_RS18735	COG0515	serine threonine protein kinase
DWG14_RS18735	COG2815	serine threonine protein kinase
DWG14_RS18765	COG0583	DNA-binding transcription factor activity
DWG14_RS18770	COG0483	inositol monophosphate 1-phosphatase activity
DWG14_RS18780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWG14_RS18790	COG3152	Membrane
DWG14_RS18795	COG0113	porphobilinogen synthase activity
DWG14_RS18805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWG14_RS18805	COG1648	precorrin-2 dehydrogenase activity
DWG14_RS18810	COG0181	hydroxymethylbilane synthase activity
DWG14_RS18815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWG14_RS18820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DWG14_RS18870	COG0123	including yeast histone deacetylase and acetoin utilization protein
DWG14_RS18875	COG0738	Major facilitator superfamily
DWG14_RS18885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWG14_RS18910	COG0180	Tryptophanyl-tRNA synthetase
DWG14_RS18915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWG14_RS18925	COG0842	Transport permease protein
DWG14_RS18925	COG1129	ABC transporter
DWG14_RS18940	COG4991	sh3 domain protein
DWG14_RS18945	COG4991	sh3 domain protein
DWG14_RS18955	COG0129	dihydroxy-acid dehydratase activity
DWG14_RS18965	COG1082	Xylose isomerase domain protein TIM barrel
DWG14_RS18970	COG0248	Ppx GppA phosphatase
DWG14_RS18995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DWG14_RS19005	COG1194	a g-specific adenine glycosylase
DWG14_RS19010	COG1595	DNA-templated transcription, initiation
DWG14_RS19020	COG0745	RESPONSE REGULATOR receiver
DWG14_RS19025	COG2205	protein histidine kinase activity
DWG14_RS19030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DWG14_RS19040	COG3708	Transcriptional regulator
DWG14_RS19040	COG2207	Transcriptional regulator
DWG14_RS19045	COG0477	Major facilitator Superfamily
DWG14_RS19055	COG0739	heme binding
DWG14_RS19090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DWG14_RS19110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DWG14_RS19120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DWG14_RS19125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWG14_RS19160	COG0649	NAD binding
DWG14_RS19185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DWG14_RS19185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWG14_RS19200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DWG14_RS19220	COG0302	gtp cyclohydrolase
DWG14_RS19235	COG0037	tRNA processing
DWG14_RS19245	COG2027	D-alanyl-D-alanine carboxypeptidase
DWG14_RS19250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DWG14_RS19260	COG0586	Pfam SNARE associated Golgi protein
DWG14_RS19265	COG0393	Putative heavy-metal-binding
DWG14_RS19270	COG0789	Transcriptional regulator
DWG14_RS19280	COG0076	glutamate decarboxylase activity
DWG14_RS19300	COG2318	DinB family
DWG14_RS19305	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS19330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWG14_RS19340	COG0254	rRNA binding
DWG14_RS19345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWG14_RS19350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWG14_RS19355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWG14_RS19380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWG14_RS19380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWG14_RS19385	COG3629	intracellular signal transduction
DWG14_RS19385	COG3903	Transcriptional regulator
DWG14_RS19410	COG0673	inositol 2-dehydrogenase activity
DWG14_RS19455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWG14_RS19460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWG14_RS19460	COG1754	DNA topoisomerase type I activity
DWG14_RS19480	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DWG14_RS19485	COG2172	sigma factor antagonist activity
DWG14_RS19490	COG1366	Belongs to the anti-sigma-factor antagonist family
DWG14_RS19495	COG1205	dead DEAH box helicase
DWG14_RS19495	COG1111	helicase
DWG14_RS19570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWG14_RS19575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DWG14_RS19585	COG2267	carboxylic ester hydrolase activity
DWG14_RS19650	COG0003	Pfam Anion-transporting ATPase
DWG14_RS19675	COG1408	metallophosphoesterase
DWG14_RS19730	COG1674	ftsk spoiiie
DWG14_RS19755	COG1725	Transcriptional regulator
DWG14_RS19815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWG14_RS19820	COG0640	Transcriptional regulator
DWG14_RS19825	COG2319	Wd-40 repeat
DWG14_RS19825	COG4249	Peptidase C14 caspase catalytic subunit p20
DWG14_RS19845	COG0701	Predicted permease
DWG14_RS19895	COG2205	protein histidine kinase activity
DWG14_RS19930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWG14_RS19935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWG14_RS19955	COG0693	protein deglycase activity
DWG14_RS19960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWG14_RS19965	COG1802	Transcriptional regulator
DWG14_RS19995	COG0737	Belongs to the 5'-nucleotidase family
DWG14_RS20000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWG14_RS20015	COG4303	Ethanolamine ammonia lyase large subunit
DWG14_RS20030	COG1131	(ABC) transporter
DWG14_RS20035	COG3559	Exporter of polyketide antibiotics
DWG14_RS20050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DWG14_RS20095	COG2197	response regulator
DWG14_RS20100	COG4585	Histidine kinase
DWG14_RS20105	COG2197	response regulator
DWG14_RS20110	COG4585	Histidine kinase
DWG14_RS20130	COG3844	kynureninase activity
DWG14_RS20145	COG0477	Major facilitator Superfamily
DWG14_RS20150	COG0191	fructose-bisphosphate aldolase activity
DWG14_RS20155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWG14_RS20170	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DWG14_RS20210	COG1136	(ABC) transporter
DWG14_RS20240	COG0542	response to heat
DWG14_RS20285	COG1305	Transglutaminase-like
DWG14_RS20290	COG4213	ABC transporter substrate-binding protein
DWG14_RS20305	COG0789	Transcriptional regulator
DWG14_RS20310	COG0484	heat shock protein binding
DWG14_RS20315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWG14_RS20320	COG0443	Heat shock 70 kDa protein
DWG14_RS20325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWG14_RS20330	COG2181	nitrate reductase activity
DWG14_RS20330	COG0247	lactate metabolic process
DWG14_RS20370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DWG14_RS20375	COG0717	Belongs to the dCTP deaminase family
DWG14_RS20405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWG14_RS20455	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS20460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DWG14_RS20465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWG14_RS20550	COG1733	regulation of RNA biosynthetic process
DWG14_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS20585	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
DWG14_RS20605	COG1595	DNA-templated transcription, initiation
DWG14_RS20625	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS20630	COG3958	Transketolase
DWG14_RS20635	COG3959	Transketolase, thiamine diphosphate binding domain
DWG14_RS20640	COG0477	Major facilitator Superfamily
DWG14_RS20675	COG0583	DNA-binding transcription factor activity
DWG14_RS20700	COG0662	Cupin 2, conserved barrel domain protein
DWG14_RS20710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWG14_RS20715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWG14_RS20720	COG2867	negative regulation of translational initiation
DWG14_RS20770	COG1278	Cold shock
DWG14_RS20775	COG0513	Belongs to the DEAD box helicase family
DWG14_RS20810	COG2755	lipolytic protein G-D-S-L family
DWG14_RS20810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DWG14_RS20830	COG3387	PFAM Glycoside hydrolase 15-related
DWG14_RS20835	COG0477	Major facilitator Superfamily
DWG14_RS20855	COG4585	Histidine kinase
DWG14_RS20860	COG2409	Drug exporters of the RND superfamily
DWG14_RS20875	COG0135	phosphoribosylanthranilate isomerase activity
DWG14_RS20895	COG1595	DNA-templated transcription, initiation
DWG14_RS20910	COG2197	response regulator
DWG14_RS20915	COG4585	Histidine kinase
DWG14_RS20920	COG4213	ABC transporter substrate-binding protein
DWG14_RS20955	COG0366	Alpha amylase catalytic
DWG14_RS20975	COG0640	Transcriptional regulator
DWG14_RS20980	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWG14_RS20985	COG1957	nucleoside hydrolase
DWG14_RS20990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWG14_RS21010	COG2197	response regulator
DWG14_RS21015	COG4585	Histidine kinase
DWG14_RS21085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWG14_RS21090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWG14_RS21100	COG1289	transmembrane transporter activity
DWG14_RS21110	COG0583	DNA-binding transcription factor activity
DWG14_RS21125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWG14_RS21140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWG14_RS21155	COG1741	Belongs to the pirin family
DWG14_RS21175	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS21180	COG1362	aminopeptidase activity
DWG14_RS21195	COG0662	Cupin 2, conserved barrel domain protein
DWG14_RS21220	COG2271	Major facilitator Superfamily
DWG14_RS21240	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWG14_RS21245	COG0022	dehydrogenase e1 component
DWG14_RS21260	COG0515	serine threonine protein kinase
DWG14_RS21275	COG0604	alcohol dehydrogenase
DWG14_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS21275	COG3321	synthase
DWG14_RS21320	COG1522	sequence-specific DNA binding
DWG14_RS21325	COG1309	transcriptional regulator
DWG14_RS21330	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWG14_RS21380	COG2197	response regulator
DWG14_RS21390	COG1136	(ABC) transporter
DWG14_RS21395	COG0577	efflux transmembrane transporter activity
DWG14_RS21405	COG1716	ATPase activity
DWG14_RS21410	COG1716	ATPase activity
DWG14_RS21425	COG0768	penicillin binding
DWG14_RS21435	COG0515	serine threonine protein kinase
DWG14_RS21440	COG3764	Sortase (surface protein transpeptidase)
DWG14_RS21445	COG3764	Sortase (surface protein transpeptidase)
DWG14_RS21460	COG3764	Sortase (surface protein transpeptidase)
DWG14_RS21475	COG0705	Rhomboid family
DWG14_RS21535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWG14_RS21540	COG0187	DNA topoisomerase II activity
DWG14_RS21545	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DWG14_RS21550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWG14_RS21555	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DWG14_RS21560	COG0592	DNA-directed DNA polymerase activity
DWG14_RS21570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWG14_RS21580	COG0594	ribonuclease P activity
DWG14_RS21585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DWG14_RS21590	COG0706	membrane insertase activity
DWG14_RS21600	COG0357	Ribosomal RNA small subunit methyltransferase G
DWG14_RS21605	COG1192	Involved in chromosome partitioning
DWG14_RS21620	COG3118	belongs to the thioredoxin family
DWG14_RS21625	COG0492	ferredoxin-NADP+ reductase activity
DWG14_RS21635	COG1595	DNA-templated transcription, initiation
DWG14_RS21650	COG0515	serine threonine protein kinase
DWG14_RS21650	COG2815	serine threonine protein kinase
DWG14_RS21665	COG0617	tRNA 3'-terminal CCA addition
DWG14_RS21675	COG1260	myo-inositol-1-phosphate synthase
DWG14_RS21685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWG14_RS21710	COG0360	Binds together with S18 to 16S ribosomal RNA
DWG14_RS21715	COG0629	single-stranded DNA binding
DWG14_RS21720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWG14_RS21725	COG0359	binds to the 23S rRNA
DWG14_RS21735	COG0305	Participates in initiation and elongation during chromosome replication
DWG14_RS21740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DWG14_RS21745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS21755	COG2814	Major facilitator Superfamily
DWG14_RS21785	COG0626	cystathionine gamma-synthase activity
DWG14_RS21790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWG14_RS21795	COG1950	PFAM Membrane protein of
DWG14_RS21800	COG0662	Cupin 2, conserved barrel domain protein
DWG14_RS21830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DWG14_RS21850	COG1609	Transcriptional regulator
DWG14_RS21855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWG14_RS21860	COG1271	oxidase subunit
DWG14_RS21865	COG1294	oxidase, subunit
DWG14_RS21870	COG4988	ABC transporter
DWG14_RS21875	COG0739	heme binding
DWG14_RS21875	COG0741	lytic transglycosylase activity
DWG14_RS21875	COG1196	nuclear chromosome segregation
DWG14_RS21880	COG0561	phosphatase activity
DWG14_RS21895	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DWG14_RS21900	COG0789	Transcriptional regulator
DWG14_RS21920	COG1131	(ABC) transporter
DWG14_RS21950	COG0561	phosphatase activity
DWG14_RS21955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWG14_RS21965	COG2837	iron assimilation
DWG14_RS21980	COG1999	signal sequence binding
DWG14_RS22000	COG2267	carboxylic ester hydrolase activity
DWG14_RS22065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWG14_RS22085	COG0653	protein targeting
DWG14_RS22105	COG0006	proline dipeptidase activity
DWG14_RS22120	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DWG14_RS22130	COG0641	radical SAM
DWG14_RS22160	COG1595	DNA-templated transcription, initiation
DWG14_RS22165	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS22170	COG2814	Major facilitator Superfamily
DWG14_RS22175	COG1309	transcriptional regulator
DWG14_RS22210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS22210	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DWG14_RS22255	COG1846	Transcriptional regulator
DWG14_RS22270	COG0745	RESPONSE REGULATOR receiver
DWG14_RS22275	COG2205	protein histidine kinase activity
DWG14_RS22285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DWG14_RS22290	COG0477	Major facilitator Superfamily
DWG14_RS22300	COG3467	pyridoxamine 5'-phosphate
DWG14_RS22305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWG14_RS22310	COG2353	YceI-like domain
DWG14_RS22315	COG0477	Major facilitator Superfamily
DWG14_RS22335	COG1191	sigma factor activity
DWG14_RS22340	COG1191	sigma factor activity
DWG14_RS22375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWG14_RS22390	COG0433	COG0433 Predicted ATPase
DWG14_RS22495	COG1609	Transcriptional regulator
DWG14_RS22565	COG0151	Belongs to the GarS family
DWG14_RS22580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWG14_RS22590	COG2197	response regulator
DWG14_RS22625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWG14_RS22630	COG0047	phosphoribosylformylglycinamidine synthase activity
DWG14_RS22635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWG14_RS22655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWG14_RS22665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DWG14_RS22690	COG1643	Atp-dependent helicase
DWG14_RS22730	COG0513	Belongs to the DEAD box helicase family
DWG14_RS22750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWG14_RS22750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWG14_RS22760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWG14_RS22785	COG0667	Aldo Keto reductase
DWG14_RS22795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWG14_RS22800	COG0579	oxidoreductase
DWG14_RS22830	COG1252	NADH dehydrogenase
DWG14_RS22925	COG1196	nuclear chromosome segregation
DWG14_RS22925	COG0741	lytic transglycosylase activity
DWG14_RS22925	COG0739	heme binding
DWG14_RS22930	COG0671	phosphoesterase, PA-phosphatase related
DWG14_RS22935	COG0277	FAD linked oxidase domain protein
DWG14_RS22955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWG14_RS22960	COG0306	phosphate transporter
DWG14_RS22970	COG1937	Protein conserved in bacteria
DWG14_RS23000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWG14_RS23015	COG1131	(ABC) transporter
DWG14_RS23020	COG1725	Transcriptional regulator
DWG14_RS23035	COG1131	(ABC) transporter
DWG14_RS23050	COG0456	acetyltransferase
DWG14_RS23055	COG0737	Belongs to the 5'-nucleotidase family
DWG14_RS23100	COG0745	RESPONSE REGULATOR receiver
DWG14_RS23110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWG14_RS23115	COG1609	Transcriptional regulator
DWG14_RS23120	COG0745	RESPONSE REGULATOR receiver
DWG14_RS23155	COG2897	thiosulfate sulfurtransferase activity
DWG14_RS23200	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS23210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DWG14_RS23220	COG0735	belongs to the Fur family
DWG14_RS23240	COG1490	D-aminoacyl-tRNA deacylase activity
DWG14_RS23250	COG4552	Acetyltransferase involved in intracellular survival and related
DWG14_RS23260	COG2188	Transcriptional regulator
DWG14_RS23270	COG2188	Transcriptional regulator
DWG14_RS23280	COG2188	Transcriptional regulator
DWG14_RS23295	COG3973	AAA domain
DWG14_RS23315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWG14_RS23355	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS23385	COG0588	phosphoglycerate mutase activity
DWG14_RS23450	COG1329	Transcriptional regulator
DWG14_RS23460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DWG14_RS23465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWG14_RS23470	COG0215	cysteine-tRNA ligase activity
DWG14_RS23475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWG14_RS23485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DWG14_RS23495	COG3842	ATPase activity
DWG14_RS23570	COG0583	DNA-binding transcription factor activity
DWG14_RS23575	COG0667	Aldo Keto reductase
DWG14_RS23630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DWG14_RS23645	COG5001	Diguanylate cyclase
DWG14_RS23645	COG3300	MHYT domain
DWG14_RS23655	COG1105	Belongs to the carbohydrate kinase PfkB family
DWG14_RS23685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DWG14_RS23690	COG0463	Glycosyl transferase, family 2
DWG14_RS23705	COG1278	Cold shock
DWG14_RS23710	COG0459	protein refolding
DWG14_RS23725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DWG14_RS23750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWG14_RS23755	COG1737	Transcriptional regulator
DWG14_RS23790	COG3973	AAA domain
DWG14_RS23800	COG1061	Type III restriction enzyme res subunit
DWG14_RS23830	COG1278	Cold shock
DWG14_RS23840	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DWG14_RS23845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWG14_RS23855	COG2814	Major facilitator Superfamily
DWG14_RS23870	COG1595	DNA-templated transcription, initiation
DWG14_RS23890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWG14_RS23905	COG2252	PERMEase
DWG14_RS23915	COG1846	Transcriptional regulator
DWG14_RS23935	COG0667	Aldo Keto reductase
DWG14_RS23950	COG3321	synthase
DWG14_RS23950	COG0604	alcohol dehydrogenase
DWG14_RS23965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DWG14_RS23980	COG0596	Alpha beta hydrolase
DWG14_RS23985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DWG14_RS23990	COG0247	lactate metabolic process
DWG14_RS23990	COG0277	FAD linked oxidase domain protein
DWG14_RS24005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWG14_RS24020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWG14_RS24035	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS24055	COG0259	pyridoxamine-phosphate oxidase activity
DWG14_RS24070	COG4821	SIS domain
DWG14_RS24080	COG0596	Alpha beta hydrolase
DWG14_RS24080	COG2945	thiolester hydrolase activity
DWG14_RS24145	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS24150	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS24155	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS24175	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS24180	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS24185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DWG14_RS24215	COG1024	Enoyl-CoA hydratase
DWG14_RS24225	COG1231	oxidoreductase activity
DWG14_RS24230	COG2072	flavoprotein involved in K transport
DWG14_RS24245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWG14_RS24255	COG2226	methyltransferase
DWG14_RS24270	COG0259	pyridoxamine-phosphate oxidase activity
DWG14_RS24290	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS24300	COG1309	transcriptional regulator
DWG14_RS24310	COG0515	serine threonine protein kinase
DWG14_RS24310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWG14_RS24320	COG0596	Alpha beta hydrolase
DWG14_RS24325	COG1024	Enoyl-CoA hydratase
DWG14_RS24340	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS24350	COG3903	Transcriptional regulator
DWG14_RS24350	COG3629	intracellular signal transduction
DWG14_RS24395	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS24425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS24435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DWG14_RS24465	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS24480	COG0443	Heat shock 70 kDa protein
DWG14_RS24485	COG0515	serine threonine protein kinase
DWG14_RS24495	COG1686	Belongs to the peptidase S11 family
DWG14_RS24515	COG0386	Belongs to the glutathione peroxidase family
DWG14_RS24560	COG3973	AAA domain
DWG14_RS24585	COG1414	Transcriptional regulator
DWG14_RS24605	COG1846	Transcriptional regulator
DWG14_RS24610	COG3384	dioxygenase
DWG14_RS24615	COG1247	-acetyltransferase
DWG14_RS24645	COG0477	Major facilitator Superfamily
DWG14_RS24650	COG1349	DNA-binding transcription factor activity
DWG14_RS24660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWG14_RS24660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWG14_RS24675	COG1376	ErfK ybiS ycfS ynhG family protein
DWG14_RS24685	COG3191	aminopeptidase activity
DWG14_RS24700	COG1970	mechanosensitive ion channel activity
DWG14_RS24710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DWG14_RS24720	COG0477	Major facilitator Superfamily
DWG14_RS24735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWG14_RS24740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWG14_RS24750	COG0315	cyclic pyranopterin monophosphate synthase activity
DWG14_RS24755	COG0315	cyclic pyranopterin monophosphate synthase activity
DWG14_RS24755	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWG14_RS24780	COG0708	Exodeoxyribonuclease III
DWG14_RS24795	COG2072	flavoprotein involved in K transport
DWG14_RS24800	COG2267	carboxylic ester hydrolase activity
DWG14_RS24805	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS24815	COG0793	Belongs to the peptidase S41A family
DWG14_RS24815	COG4946	Tricorn protease homolog
DWG14_RS24825	COG0456	acetyltransferase
DWG14_RS24830	COG0442	prolyl-tRNA aminoacylation
DWG14_RS24840	COG1131	(ABC) transporter
DWG14_RS24860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS24865	COG1764	response to oxidative stress
DWG14_RS24870	COG1846	Transcriptional regulator
DWG14_RS24875	COG1122	ATPase activity
DWG14_RS24885	COG0310	cobalt ion transport
DWG14_RS24920	COG0084	hydrolase, TatD family'
DWG14_RS24925	COG3584	3D domain protein
DWG14_RS24925	COG3583	domain protein
DWG14_RS24930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWG14_RS24935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWG14_RS24940	COG0488	(ABC) transporter
DWG14_RS24970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWG14_RS24985	COG2197	response regulator
DWG14_RS24995	COG4106	trans-aconitate 2-methyltransferase activity
DWG14_RS25010	COG1309	transcriptional regulator
DWG14_RS25020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DWG14_RS25035	COG0193	aminoacyl-tRNA hydrolase activity
DWG14_RS25040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWG14_RS25045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWG14_RS25050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWG14_RS25060	COG4585	Histidine kinase
DWG14_RS25090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS25100	COG0477	Major facilitator Superfamily
DWG14_RS25105	COG1136	(ABC) transporter
DWG14_RS25110	COG0577	efflux transmembrane transporter activity
DWG14_RS25200	COG0148	phosphopyruvate hydratase activity
DWG14_RS25220	COG1252	NADH dehydrogenase
DWG14_RS25225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWG14_RS25230	COG0577	efflux transmembrane transporter activity
DWG14_RS25235	COG1136	(ABC) transporter
DWG14_RS25300	COG0183	Belongs to the thiolase family
DWG14_RS25305	COG2755	lipolytic protein G-D-S-L family
DWG14_RS25320	COG4221	oxidoreductase activity
DWG14_RS25335	COG1174	glycine betaine transport
DWG14_RS25340	COG1174	glycine betaine transport
DWG14_RS25390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DWG14_RS25395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWG14_RS25405	COG1228	amidohydrolase
DWG14_RS25415	COG1191	sigma factor activity
DWG14_RS25420	COG1366	Belongs to the anti-sigma-factor antagonist family
DWG14_RS25450	COG3104	oligopeptide transport
DWG14_RS25455	COG0745	RESPONSE REGULATOR receiver
DWG14_RS25460	COG2205	protein histidine kinase activity
DWG14_RS25535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DWG14_RS25555	COG1316	TRANSCRIPTIONal
DWG14_RS25565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DWG14_RS25570	COG1316	TRANSCRIPTIONal
DWG14_RS25585	COG1316	TRANSCRIPTIONal
DWG14_RS25590	COG1316	TRANSCRIPTIONal
DWG14_RS25595	COG1316	TRANSCRIPTIONal
DWG14_RS25600	COG1316	TRANSCRIPTIONal
DWG14_RS25625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DWG14_RS25625	COG0778	Nitroreductase
DWG14_RS25630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWG14_RS25665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWG14_RS25675	COG2835	tetraacyldisaccharide 4'-kinase activity
DWG14_RS25685	COG1482	cell wall glycoprotein biosynthetic process
DWG14_RS25695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DWG14_RS25740	COG0714	Associated with various cellular activities
DWG14_RS25760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DWG14_RS25820	COG2188	Transcriptional regulator
DWG14_RS25835	COG0745	RESPONSE REGULATOR receiver
DWG14_RS25840	COG5002	protein histidine kinase activity
DWG14_RS25840	COG5000	phosphorelay sensor kinase activity
DWG14_RS25845	COG0823	Involved in the tonB-independent uptake of proteins
DWG14_RS25855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWG14_RS25860	COG2197	response regulator
DWG14_RS25865	COG3214	Protein conserved in bacteria
DWG14_RS25870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWG14_RS25875	COG0653	protein targeting
DWG14_RS25900	COG2902	Dehydrogenase
DWG14_RS25905	COG1134	teichoic acid transport
DWG14_RS25935	COG1846	Transcriptional regulator
DWG14_RS25940	COG1764	response to oxidative stress
DWG14_RS25945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWG14_RS25950	COG0395	ABC-type sugar transport system, permease component
DWG14_RS25955	COG1175	transmembrane transport
DWG14_RS25965	COG1674	ftsk spoiiie
DWG14_RS25970	COG0515	serine threonine protein kinase
DWG14_RS25975	COG0515	serine threonine protein kinase
DWG14_RS25985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DWG14_RS26000	COG2884	Cell division ATP-binding protein ftsE
DWG14_RS26005	COG2177	Part of the ABC transporter FtsEX involved in
DWG14_RS26010	COG0793	Belongs to the peptidase S41A family
DWG14_RS26015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DWG14_RS26050	COG1501	Belongs to the glycosyl hydrolase 31 family
DWG14_RS26055	COG0395	ABC-type sugar transport system, permease component
DWG14_RS26060	COG1175	transmembrane transport
DWG14_RS26075	COG0583	DNA-binding transcription factor activity
DWG14_RS26110	COG2223	nitrite transmembrane transporter activity
DWG14_RS26140	COG3973	AAA domain
DWG14_RS26150	COG0776	regulation of translation
DWG14_RS26155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWG14_RS26160	COG1678	Uncharacterized ACR, COG1678
DWG14_RS26170	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWG14_RS26185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWG14_RS26200	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DWG14_RS26230	COG3654	unkown
DWG14_RS26255	COG4948	Mandelate Racemase Muconate Lactonizing
DWG14_RS26275	COG1174	glycine betaine transport
DWG14_RS26280	COG1174	glycine betaine transport
DWG14_RS26290	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DWG14_RS26315	COG0277	FAD linked oxidase domain protein
DWG14_RS26370	COG1335	isochorismatase
DWG14_RS26380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DWG14_RS26395	COG1113	amino acid transport
DWG14_RS26420	COG1234	tRNA 3'-trailer cleavage
DWG14_RS26425	COG1263	PTS System
DWG14_RS26430	COG1263	PTS System
DWG14_RS26435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWG14_RS26440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DWG14_RS26450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWG14_RS26485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWG14_RS26500	COG4555	ABC transporter
DWG14_RS26515	COG2733	membrane
DWG14_RS26535	COG0071	Belongs to the small heat shock protein (HSP20) family
DWG14_RS26610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWG14_RS26640	COG3764	Sortase (surface protein transpeptidase)
DWG14_RS26670	COG4702	Belongs to the UPF0303 family
DWG14_RS26675	COG0673	inositol 2-dehydrogenase activity
DWG14_RS26745	COG3397	chitin binding
DWG14_RS26755	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS26770	COG1126	abc transporter atp-binding protein
DWG14_RS26775	COG0765	amino acid transport
DWG14_RS26780	COG0765	amino acid transport
DWG14_RS26785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWG14_RS26800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWG14_RS26820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS26870	COG0406	alpha-ribazole phosphatase activity
DWG14_RS26895	COG0745	RESPONSE REGULATOR receiver
DWG14_RS26905	COG1653	transport
DWG14_RS26910	COG1175	transmembrane transport
DWG14_RS26915	COG0395	ABC-type sugar transport system, permease component
DWG14_RS26920	COG3345	alpha-galactosidase
DWG14_RS26930	COG0395	ABC-type sugar transport system, permease component
DWG14_RS26955	COG0583	DNA-binding transcription factor activity
DWG14_RS26965	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DWG14_RS26970	COG4977	sequence-specific DNA binding
DWG14_RS26980	COG0589	response to stress
DWG14_RS26985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWG14_RS27010	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DWG14_RS27015	COG0076	glutamate decarboxylase activity
DWG14_RS27030	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS27045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWG14_RS27050	COG1309	transcriptional regulator
DWG14_RS27060	COG1946	Acyl-CoA thioesterase
DWG14_RS27075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS27085	COG0028	Belongs to the TPP enzyme family
DWG14_RS27100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DWG14_RS27125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DWG14_RS27135	COG2356	endonuclease I
DWG14_RS27150	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DWG14_RS27185	COG1472	Belongs to the glycosyl hydrolase 3 family
DWG14_RS27195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWG14_RS27200	COG0477	Major facilitator Superfamily
DWG14_RS27220	COG0456	acetyltransferase
DWG14_RS27220	COG1846	Transcriptional regulator
DWG14_RS27250	COG1609	Transcriptional regulator
DWG14_RS27255	COG0673	inositol 2-dehydrogenase activity
DWG14_RS27270	COG1869	D-ribose catabolic process
DWG14_RS27275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWG14_RS27285	COG1129	ABC transporter
DWG14_RS27290	COG1609	Transcriptional regulator
DWG14_RS27310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWG14_RS27340	COG2409	Drug exporters of the RND superfamily
DWG14_RS27350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWG14_RS27365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWG14_RS27375	COG3718	enzyme involved in inositol metabolism
DWG14_RS27380	COG3962	Belongs to the TPP enzyme family
DWG14_RS27400	COG1131	(ABC) transporter
DWG14_RS27425	COG1316	TRANSCRIPTIONal
DWG14_RS27470	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS27480	COG0728	peptidoglycan biosynthetic process
DWG14_RS27495	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS27535	COG2304	oxidoreductase activity
DWG14_RS27550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWG14_RS27555	COG1720	tRNA m6t6A37 methyltransferase activity
DWG14_RS27605	COG1136	(ABC) transporter
DWG14_RS27605	COG0577	efflux transmembrane transporter activity
DWG14_RS27620	COG2346	COG2346, Truncated hemoglobins
DWG14_RS27675	COG1486	melibiose metabolic process
DWG14_RS27680	COG0395	ABC-type sugar transport system, permease component
DWG14_RS27685	COG1175	transmembrane transport
DWG14_RS27690	COG1653	transport
DWG14_RS27705	COG0668	transmembrane transport
DWG14_RS27720	COG1136	(ABC) transporter
DWG14_RS27775	COG1846	Transcriptional regulator
DWG14_RS27780	COG0697	spore germination
DWG14_RS27875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWG14_RS27885	COG1070	Carbohydrate kinase
DWG14_RS27900	COG0588	phosphoglycerate mutase activity
DWG14_RS27910	COG1113	amino acid transport
DWG14_RS27920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS27930	COG1116	anion transmembrane transporter activity
DWG14_RS27935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWG14_RS27945	COG1940	carbohydrate kinase activity
DWG14_RS27975	COG1113	amino acid transport
DWG14_RS27980	COG0698	ribose 5-phosphate isomerase
DWG14_RS27990	COG4552	Acetyltransferase involved in intracellular survival and related
DWG14_RS28010	COG3594	Acyltransferase
DWG14_RS28030	COG2188	Transcriptional regulator
DWG14_RS28100	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWG14_RS28105	COG0740	serine-type endopeptidase activity
DWG14_RS28110	COG0740	serine-type endopeptidase activity
DWG14_RS28115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWG14_RS28125	COG0525	valine-tRNA ligase activity
DWG14_RS28130	COG0285	dihydrofolate synthase activity
DWG14_RS28140	COG0105	UTP biosynthetic process
DWG14_RS28145	COG1077	Cell shape determining protein MreB Mrl
DWG14_RS28160	COG0768	penicillin binding
DWG14_RS28165	COG0772	Belongs to the SEDS family
DWG14_RS28215	COG0456	acetyltransferase
DWG14_RS28215	COG3153	acetyltransferase
DWG14_RS28285	COG1530	ribonuclease E activity
DWG14_RS28315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWG14_RS28320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWG14_RS28325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWG14_RS28335	COG3540	Alkaline phosphatase
DWG14_RS28350	COG1215	transferase activity, transferring glycosyl groups
DWG14_RS28360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DWG14_RS28370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DWG14_RS28385	COG0501	Belongs to the peptidase M48B family
DWG14_RS28390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWG14_RS28400	COG0799	negative regulation of ribosome biogenesis
DWG14_RS28405	COG0588	phosphoglycerate mutase activity
DWG14_RS28435	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DWG14_RS28450	COG0495	leucyl-tRNA aminoacylation
DWG14_RS28460	COG1307	EDD domain protein, DegV family
DWG14_RS28465	COG1596	polysaccharide export
DWG14_RS28465	COG1555	photosystem II stabilization
DWG14_RS28470	COG1234	tRNA 3'-trailer cleavage
DWG14_RS28495	COG0268	Binds directly to 16S ribosomal RNA
DWG14_RS28500	COG0481	GTPase activity
DWG14_RS28540	COG1420	regulation of RNA biosynthetic process
DWG14_RS28545	COG0484	heat shock protein binding
DWG14_RS28570	COG4946	Tricorn protease homolog
DWG14_RS28570	COG0793	Belongs to the peptidase S41A family
DWG14_RS28575	COG0537	adenosine 5'-monophosphoramidase activity
DWG14_RS28580	COG1234	tRNA 3'-trailer cleavage
DWG14_RS28585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWG14_RS28600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS28605	COG4948	Mandelate Racemase Muconate Lactonizing
DWG14_RS28610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWG14_RS28625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWG14_RS28635	COG2315	Protein conserved in bacteria
DWG14_RS28680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWG14_RS28700	COG2723	6-phospho-beta-galactosidase activity
DWG14_RS28720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWG14_RS28730	COG2409	Drug exporters of the RND superfamily
DWG14_RS28735	COG4585	Histidine kinase
DWG14_RS28740	COG2197	response regulator
DWG14_RS28755	COG1595	DNA-templated transcription, initiation
DWG14_RS28775	COG1381	Involved in DNA repair and RecF pathway recombination
DWG14_RS28780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWG14_RS28795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWG14_RS28800	COG1121	(ABC) transporter
DWG14_RS28805	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWG14_RS28805	COG3443	Belongs to the bacterial solute-binding protein 9 family
DWG14_RS28810	COG0423	glycine-tRNA ligase activity
DWG14_RS28815	COG0667	Aldo Keto reductase
DWG14_RS28825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWG14_RS28835	COG0477	Major facilitator Superfamily
DWG14_RS28845	COG0156	8-amino-7-oxononanoate synthase activity
DWG14_RS28860	COG2814	Major facilitator Superfamily
DWG14_RS28875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWG14_RS28900	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DWG14_RS28905	COG1940	carbohydrate kinase activity
DWG14_RS28905	COG1846	Transcriptional regulator
DWG14_RS28910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWG14_RS28910	COG0574	Belongs to the PEP-utilizing enzyme family
DWG14_RS28930	COG4221	oxidoreductase activity
DWG14_RS28940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWG14_RS28940	COG2146	nitrite reductase [NAD(P)H] activity
DWG14_RS28945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWG14_RS28955	COG3896	Chloramphenicol phosphotransferase-like protein
DWG14_RS28995	COG0243	molybdopterin cofactor binding
DWG14_RS29015	COG2949	membrane
DWG14_RS29025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DWG14_RS29035	COG0358	DNA primase activity
DWG14_RS29040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWG14_RS29055	COG1070	Carbohydrate kinase
DWG14_RS29080	COG4977	sequence-specific DNA binding
DWG14_RS29090	COG4585	Histidine kinase
DWG14_RS29100	COG0745	RESPONSE REGULATOR receiver
DWG14_RS29105	COG2205	protein histidine kinase activity
DWG14_RS29145	COG1136	(ABC) transporter
DWG14_RS29150	COG4181	ATPase activity
DWG14_RS29160	COG2205	protein histidine kinase activity
DWG14_RS29175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWG14_RS29185	COG3290	protein histidine kinase activity
DWG14_RS29190	COG4565	transcriptional regulatory protein
DWG14_RS29200	COG0671	phosphoesterase, PA-phosphatase related
DWG14_RS29205	COG0671	phosphoesterase, PA-phosphatase related
DWG14_RS29220	COG0726	polysaccharide deacetylase
DWG14_RS29225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWG14_RS29265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DWG14_RS29285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWG14_RS29310	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWG14_RS29355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DWG14_RS29365	COG0601	transmembrane transport
DWG14_RS29370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS29375	COG0444	Belongs to the ABC transporter superfamily
DWG14_RS29430	COG1487	ribonuclease activity
DWG14_RS29485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWG14_RS29510	COG0121	glutamine amidotransferase
DWG14_RS29515	COG3345	alpha-galactosidase
DWG14_RS29540	COG0531	amino acid
DWG14_RS29555	COG1077	Cell shape determining protein MreB Mrl
DWG14_RS29560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWG14_RS29560	COG0825	malonyl-CoA metabolic process
DWG14_RS29565	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS29595	COG2835	tetraacyldisaccharide 4'-kinase activity
DWG14_RS29615	COG4981	capsule polysaccharide biosynthetic process
DWG14_RS29645	COG1414	Transcriptional regulator
DWG14_RS29650	COG3386	PFAM SMP-30 Gluconolaconase
DWG14_RS29745	COG0596	Alpha beta hydrolase
DWG14_RS29745	COG2945	thiolester hydrolase activity
DWG14_RS29750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWG14_RS29760	COG4214	carbohydrate transport
DWG14_RS29765	COG1129	ABC transporter
DWG14_RS29785	COG4948	Mandelate Racemase Muconate Lactonizing
DWG14_RS29790	COG1609	Transcriptional regulator
DWG14_RS29795	COG1879	ABC-type sugar transport system periplasmic component
DWG14_RS29805	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS29810	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS29835	COG2130	NADP-dependent
DWG14_RS29840	COG1764	response to oxidative stress
DWG14_RS29865	COG0583	DNA-binding transcription factor activity
DWG14_RS29905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWG14_RS29910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWG14_RS29915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWG14_RS29930	COG1741	Belongs to the pirin family
DWG14_RS29950	COG0789	Transcriptional regulator
DWG14_RS29955	COG0667	Aldo Keto reductase
DWG14_RS29970	COG1309	transcriptional regulator
DWG14_RS29975	COG0477	Major facilitator Superfamily
DWG14_RS29985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWG14_RS29990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DWG14_RS30040	COG1358	cellular component organization or biogenesis
DWG14_RS30190	COG4122	O-methyltransferase activity
DWG14_RS30210	COG2124	cytochrome p450
DWG14_RS30215	COG0183	Belongs to the thiolase family
DWG14_RS30255	COG2267	carboxylic ester hydrolase activity
DWG14_RS30260	COG3619	membrane
DWG14_RS30280	COG3845	ABC transporter
DWG14_RS30295	COG1657	PFAM Prenyltransferase squalene oxidase
DWG14_RS30325	COG1309	transcriptional regulator
DWG14_RS30330	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS30350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS30360	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWG14_RS30370	COG0477	Major facilitator Superfamily
DWG14_RS30390	COG2197	response regulator
DWG14_RS30395	COG4585	Histidine kinase
DWG14_RS30400	COG2030	dehydratase
DWG14_RS30410	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS30420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWG14_RS30435	COG0800	Aldolase
DWG14_RS30440	COG3022	response to hydroperoxide
DWG14_RS30445	COG0557	exoribonuclease II activity
DWG14_RS30490	COG1609	Transcriptional regulator
DWG14_RS30500	COG1129	ABC transporter
DWG14_RS30505	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS30530	COG0667	Aldo Keto reductase
DWG14_RS30535	COG1136	(ABC) transporter
DWG14_RS30580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWG14_RS30600	COG3629	intracellular signal transduction
DWG14_RS30600	COG3903	Transcriptional regulator
DWG14_RS30645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWG14_RS30670	COG2814	Major facilitator Superfamily
DWG14_RS30675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS30700	COG0672	)-iron permease
DWG14_RS30705	COG2837	iron assimilation
DWG14_RS30755	COG1994	Peptidase M50
DWG14_RS30785	COG2814	Major facilitator Superfamily
DWG14_RS30800	COG0477	Major facilitator Superfamily
DWG14_RS30805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DWG14_RS30840	COG0174	glutamine synthetase
DWG14_RS30845	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DWG14_RS30860	COG1902	pentaerythritol trinitrate reductase activity
DWG14_RS30860	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWG14_RS30875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DWG14_RS30880	COG0697	spore germination
DWG14_RS30885	COG0583	DNA-binding transcription factor activity
DWG14_RS30895	COG1609	Transcriptional regulator
DWG14_RS30900	COG1653	transport
DWG14_RS30905	COG1175	transmembrane transport
DWG14_RS30910	COG3833	ABC-type maltose transport systems, permease component
DWG14_RS30915	COG0366	Alpha amylase catalytic
DWG14_RS30950	COG1309	transcriptional regulator
DWG14_RS30975	COG2197	response regulator
DWG14_RS30980	COG4585	Histidine kinase
DWG14_RS30995	COG0745	RESPONSE REGULATOR receiver
DWG14_RS31040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS31060	COG0501	Belongs to the peptidase M48B family
DWG14_RS31075	COG0174	glutamine synthetase
DWG14_RS31100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWG14_RS31105	COG0321	lipoyl(octanoyl) transferase activity
DWG14_RS31155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DWG14_RS31170	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWG14_RS31175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWG14_RS31180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWG14_RS31190	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DWG14_RS31210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DWG14_RS31230	COG2226	methyltransferase
DWG14_RS31250	COG4585	Histidine kinase
DWG14_RS31255	COG2197	response regulator
DWG14_RS31260	COG3795	YCII-related domain
DWG14_RS31265	COG4941	Belongs to the sigma-70 factor family
DWG14_RS31275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DWG14_RS31300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWG14_RS31310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWG14_RS31315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DWG14_RS31325	COG1376	ErfK ybiS ycfS ynhG family protein
DWG14_RS31335	COG1845	cytochrome c oxidase, subunit III
DWG14_RS31340	COG2010	Cytochrome c
DWG14_RS31345	COG0723	plastoquinol--plastocyanin reductase activity
DWG14_RS31350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DWG14_RS31355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWG14_RS31360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWG14_RS31390	COG1388	LysM domain
DWG14_RS31390	COG3103	Sh3 type 3 domain protein
DWG14_RS31390	COG0791	NLP P60 protein
DWG14_RS31410	COG0534	Mate efflux family protein
DWG14_RS31445	COG0003	Pfam Anion-transporting ATPase
DWG14_RS31455	COG1940	carbohydrate kinase activity
DWG14_RS31485	COG2197	response regulator
DWG14_RS31490	COG0205	6-phosphofructokinase activity
DWG14_RS31505	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWG14_RS31510	COG0243	molybdopterin cofactor binding
DWG14_RS31515	COG2193	ferroxidase activity
DWG14_RS31520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWG14_RS31530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DWG14_RS31540	COG2815	serine threonine protein kinase
DWG14_RS31540	COG0515	serine threonine protein kinase
DWG14_RS31545	COG2022	thiamine diphosphate biosynthetic process
DWG14_RS31555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWG14_RS31555	COG2022	thiamine diphosphate biosynthetic process
DWG14_RS31575	COG0352	thiamine-phosphate diphosphorylase activity
DWG14_RS31600	COG1309	transcriptional regulator
DWG14_RS31610	COG1131	(ABC) transporter
DWG14_RS31640	COG0714	Associated with various cellular activities
DWG14_RS31650	COG0275	rRNA processing
DWG14_RS31665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWG14_RS31675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWG14_RS31680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWG14_RS31690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWG14_RS31700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWG14_RS31705	COG1496	oxidoreductase activity
DWG14_RS31715	COG1799	cell septum assembly
DWG14_RS31725	COG3599	regulation of cell shape
DWG14_RS31730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWG14_RS31745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWG14_RS31800	COG0587	DNA-directed DNA polymerase activity
DWG14_RS31805	COG1432	Conserved Protein
DWG14_RS31895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWG14_RS31915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWG14_RS31920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWG14_RS31925	COG0131	Imidazoleglycerol-phosphate dehydratase
DWG14_RS31930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DWG14_RS31935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DWG14_RS31940	COG0251	oxidation-reduction process
DWG14_RS31945	COG0107	imidazoleglycerol-phosphate synthase activity
DWG14_RS31965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DWG14_RS31970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWG14_RS31990	COG0134	indole-3-glycerol-phosphate synthase activity
DWG14_RS32000	COG0133	tryptophan synthase activity
DWG14_RS32005	COG0159	tryptophan synthase activity
DWG14_RS32015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWG14_RS32025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS32030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWG14_RS32060	COG0067	glutamate synthase
DWG14_RS32060	COG0070	glutamate synthase
DWG14_RS32060	COG0069	glutamate synthase activity
DWG14_RS32080	COG1846	Transcriptional regulator
DWG14_RS32085	COG0477	Major facilitator Superfamily
DWG14_RS32105	COG0287	Prephenate dehydrogenase
DWG14_RS32105	COG1605	Chorismate mutase
DWG14_RS32110	COG4566	intracellular signal transduction
DWG14_RS32130	COG0737	Belongs to the 5'-nucleotidase family
DWG14_RS32190	COG2050	protein possibly involved in aromatic compounds catabolism
DWG14_RS32230	COG1643	Atp-dependent helicase
DWG14_RS32235	COG2226	methyltransferase
DWG14_RS32250	COG0237	dephospho-CoA kinase activity
DWG14_RS32285	COG1802	Transcriptional regulator
DWG14_RS32290	COG1953	Uracil, thiamine, allantoin
DWG14_RS32330	COG0402	S-adenosylhomocysteine deaminase activity
DWG14_RS32345	COG1132	(ABC) transporter
DWG14_RS32370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWG14_RS32375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWG14_RS32405	COG0598	Magnesium transport protein CorA
DWG14_RS32410	COG2226	methyltransferase
DWG14_RS32415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DWG14_RS32415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DWG14_RS32420	COG2313	pseudouridylate synthase activity
DWG14_RS32430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWG14_RS32435	COG0584	glycerophosphoryl diester phosphodiesterase
DWG14_RS32445	COG0556	nucleotide-excision repair
DWG14_RS32470	COG0387	Pfam Sodium calcium exchanger
DWG14_RS32475	COG1619	proteins homologs of microcin C7 resistance protein MccF
DWG14_RS32480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DWG14_RS32490	COG0765	amino acid transport
DWG14_RS32495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWG14_RS32505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS32525	COG0477	Major facilitator Superfamily
DWG14_RS32560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWG14_RS32570	COG1609	Transcriptional regulator
DWG14_RS32585	COG0322	excinuclease ABC activity
DWG14_RS32590	COG1660	Displays ATPase and GTPase activities
DWG14_RS32595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWG14_RS32600	COG1481	regulation of sporulation
DWG14_RS32610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWG14_RS32615	COG0126	phosphoglycerate kinase activity
DWG14_RS32620	COG0149	triose-phosphate isomerase activity
DWG14_RS32625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWG14_RS32635	COG0166	Belongs to the GPI family
DWG14_RS32645	COG0363	glucosamine-6-phosphate deaminase activity
DWG14_RS32660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWG14_RS32675	COG0109	protoheme IX farnesyltransferase activity
DWG14_RS32710	COG1131	(ABC) transporter
DWG14_RS32715	COG2746	aminoglycoside 3-N-acetyltransferase activity
DWG14_RS32730	COG0719	Fe-S assembly protein
DWG14_RS32740	COG0396	ATPase activity
DWG14_RS32745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWG14_RS32750	COG0822	iron-sulfur transferase activity
DWG14_RS32755	COG2151	metal-sulfur cluster biosynthetic enzyme
DWG14_RS32770	COG3226	Transcriptional regulator
DWG14_RS32775	COG2171	N-acyltransferase activity
DWG14_RS32780	COG1595	DNA-templated transcription, initiation
DWG14_RS32790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS32810	COG1959	2 iron, 2 sulfur cluster binding
DWG14_RS32810	COG1295	ribonuclease BN
DWG14_RS32850	COG1802	Transcriptional regulator
DWG14_RS32870	COG1609	Transcriptional regulator
DWG14_RS32875	COG2017	converts alpha-aldose to the beta-anomer
DWG14_RS32895	COG1609	Transcriptional regulator
DWG14_RS32905	COG1621	beta-fructofuranosidase activity
DWG14_RS32910	COG1609	Transcriptional regulator
DWG14_RS32915	COG1309	transcriptional regulator
DWG14_RS32925	COG1063	alcohol dehydrogenase
DWG14_RS32930	COG0395	ABC-type sugar transport system, permease component
DWG14_RS32945	COG1349	DNA-binding transcription factor activity
DWG14_RS32950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWG14_RS32955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS32980	COG1802	Transcriptional regulator
DWG14_RS32985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS32995	COG1175	transmembrane transport
DWG14_RS33000	COG0395	ABC-type sugar transport system, permease component
DWG14_RS33010	COG0673	inositol 2-dehydrogenase activity
DWG14_RS33025	COG2755	lipolytic protein G-D-S-L family
DWG14_RS33030	COG3866	Pectate lyase
DWG14_RS33040	COG4677	pectinesterase activity
DWG14_RS33065	COG1595	DNA-templated transcription, initiation
DWG14_RS33070	COG2252	PERMEase
DWG14_RS33085	COG1414	Transcriptional regulator
DWG14_RS33115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWG14_RS33120	COG5285	phytanoyl-CoA dioxygenase
DWG14_RS33125	COG1917	Cupin 2, conserved barrel domain protein
DWG14_RS33130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWG14_RS33135	COG0456	acetyltransferase
DWG14_RS33140	COG2318	DinB family
DWG14_RS33145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DWG14_RS33150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWG14_RS33155	COG0765	amino acid transport
DWG14_RS33160	COG1126	abc transporter atp-binding protein
DWG14_RS33165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWG14_RS33185	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DWG14_RS33220	COG1797	cobyrinic acid a,c-diamide synthase activity
DWG14_RS33240	COG1492	cobalamin metabolic process
DWG14_RS33245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DWG14_RS33260	COG0235	Class ii aldolase
DWG14_RS33285	COG0488	(ABC) transporter
DWG14_RS33295	COG1024	Enoyl-CoA hydratase
DWG14_RS33335	COG3387	PFAM Glycoside hydrolase 15-related
DWG14_RS33350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWG14_RS33370	COG1063	alcohol dehydrogenase
DWG14_RS33380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWG14_RS33400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS33405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWG14_RS33435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWG14_RS33445	COG0312	modulator of DNA gyrase
DWG14_RS33465	COG2186	Transcriptional regulator
DWG14_RS33480	COG0588	phosphoglycerate mutase activity
DWG14_RS33485	COG3830	Belongs to the UPF0237 family
DWG14_RS33485	COG0560	Phosphoserine phosphatase
DWG14_RS33495	COG0842	Transport permease protein
DWG14_RS33495	COG1131	(ABC) transporter
DWG14_RS33495	COG1716	ATPase activity
DWG14_RS33505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DWG14_RS33510	COG4221	oxidoreductase activity
DWG14_RS33520	COG2197	response regulator
DWG14_RS33540	COG1119	ATPase activity
DWG14_RS33560	COG1881	PFAM PEBP family protein
DWG14_RS33570	COG2094	Belongs to the DNA glycosylase MPG family
DWG14_RS33605	COG0647	UMP catabolic process
DWG14_RS33610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWG14_RS33615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWG14_RS33625	COG1120	ATPase activity
DWG14_RS33645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWG14_RS33650	COG0497	DNA recombination
DWG14_RS33675	COG3387	PFAM Glycoside hydrolase 15-related
DWG14_RS33680	COG0504	CTP synthase activity
DWG14_RS33685	COG0494	nUDIX hydrolase
DWG14_RS33695	COG0686	Belongs to the AlaDH PNT family
DWG14_RS33710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWG14_RS33715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWG14_RS33720	COG1187	pseudouridine synthase activity
DWG14_RS33765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWG14_RS33775	COG1160	GTP binding
DWG14_RS33800	COG0411	ABC transporter
DWG14_RS33820	COG0596	Alpha beta hydrolase
DWG14_RS33840	COG0671	phosphoesterase, PA-phosphatase related
DWG14_RS33860	COG0477	Major facilitator Superfamily
DWG14_RS33865	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS33870	COG1799	cell septum assembly
DWG14_RS33880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS33885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS33905	COG0330	HflC and HflK could
DWG14_RS33970	COG0587	DNA-directed DNA polymerase activity
DWG14_RS34000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DWG14_RS34000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWG14_RS34010	COG2226	methyltransferase
DWG14_RS34025	COG1725	Transcriptional regulator
DWG14_RS34050	COG0726	polysaccharide deacetylase
DWG14_RS34050	COG1649	PFAM Uncharacterised BCR, COG1649
DWG14_RS34060	COG0463	Glycosyl transferase, family 2
DWG14_RS34080	COG2755	lipolytic protein G-D-S-L family
DWG14_RS34085	COG0515	serine threonine protein kinase
DWG14_RS34085	COG2815	serine threonine protein kinase
DWG14_RS34105	COG1595	DNA-templated transcription, initiation
DWG14_RS34140	COG2188	Transcriptional regulator
DWG14_RS34145	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DWG14_RS34155	COG1309	transcriptional regulator
DWG14_RS34160	COG0243	molybdopterin cofactor binding
DWG14_RS34165	COG2851	Citrate transporter
DWG14_RS34210	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS34265	COG3876	Protein conserved in bacteria
DWG14_RS34275	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS34285	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS34305	COG2149	membrane
DWG14_RS34310	COG0745	RESPONSE REGULATOR receiver
DWG14_RS34315	COG2205	protein histidine kinase activity
DWG14_RS34320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DWG14_RS34360	COG3265	gluconokinase activity
DWG14_RS34365	COG2186	Transcriptional regulator
DWG14_RS34370	COG3012	SEC-C Motif Domain Protein
DWG14_RS34375	COG0308	aminopeptidase N
DWG14_RS34420	COG0667	Aldo Keto reductase
DWG14_RS34425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS34435	COG0598	Magnesium transport protein CorA
DWG14_RS34440	COG0588	phosphoglycerate mutase activity
DWG14_RS34455	COG0215	cysteine-tRNA ligase activity
DWG14_RS34470	COG2186	Transcriptional regulator
DWG14_RS34475	COG0235	Class ii aldolase
DWG14_RS34475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DWG14_RS34480	COG0235	Class ii aldolase
DWG14_RS34485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DWG14_RS34490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DWG14_RS34500	COG1129	ABC transporter
DWG14_RS34510	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DWG14_RS34520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWG14_RS34525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWG14_RS34530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWG14_RS34535	COG1414	Transcriptional regulator
DWG14_RS34540	COG0646	methionine synthase
DWG14_RS34540	COG1410	methionine synthase
DWG14_RS34545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWG14_RS34550	COG0747	negative chemotaxis
DWG14_RS34555	COG4166	transmembrane transport
DWG14_RS34560	COG2197	response regulator
DWG14_RS34570	COG0517	IMP dehydrogenase activity
DWG14_RS34570	COG1994	Peptidase M50
DWG14_RS34595	COG1222	aaa ATPase
DWG14_RS34600	COG4122	O-methyltransferase activity
DWG14_RS34615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWG14_RS34620	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWG14_RS34625	COG1609	Transcriptional regulator
DWG14_RS34635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWG14_RS34640	COG0545	Peptidyl-prolyl cis-trans isomerase
DWG14_RS34670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWG14_RS34675	COG0805	protein transport
DWG14_RS34745	COG0564	pseudouridine synthase activity
DWG14_RS34770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWG14_RS34775	COG4175	Glycine betaine
DWG14_RS34775	COG0517	IMP dehydrogenase activity
DWG14_RS34780	COG4176	ABC-type proline glycine betaine transport system permease component
DWG14_RS34790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWG14_RS34805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DWG14_RS34815	COG0174	glutamine synthetase
DWG14_RS34820	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS34870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWG14_RS34875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWG14_RS34880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWG14_RS34885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWG14_RS34890	COG5002	protein histidine kinase activity
DWG14_RS34895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWG14_RS34900	COG0072	phenylalanine-tRNA ligase activity
DWG14_RS34900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWG14_RS34930	COG1649	PFAM Uncharacterised BCR, COG1649
DWG14_RS34940	COG0697	spore germination
DWG14_RS34980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DWG14_RS34985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DWG14_RS34990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWG14_RS34995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWG14_RS35000	COG1438	arginine binding
DWG14_RS35015	COG1017	nitric oxide dioxygenase activity
DWG14_RS35015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWG14_RS35025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWG14_RS35030	COG0745	RESPONSE REGULATOR receiver
DWG14_RS35035	COG2205	protein histidine kinase activity
DWG14_RS35050	COG0165	Argininosuccinate lyase
DWG14_RS35065	COG0477	Major facilitator Superfamily
DWG14_RS35070	COG0204	Acyl-transferase
DWG14_RS35070	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS35075	COG0584	glycerophosphoryl diester phosphodiesterase
DWG14_RS35105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWG14_RS35110	COG2011	ABC-type metal ion transport system permease component
DWG14_RS35115	COG1464	Belongs to the NlpA lipoprotein family
DWG14_RS35130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DWG14_RS35135	COG1648	precorrin-2 dehydrogenase activity
DWG14_RS35135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWG14_RS35195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWG14_RS35240	COG1653	transport
DWG14_RS35245	COG1175	transmembrane transport
DWG14_RS35250	COG0395	ABC-type sugar transport system, permease component
DWG14_RS35280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWG14_RS35295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWG14_RS35300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DWG14_RS35320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWG14_RS35325	COG1560	Kdo2-lipid A biosynthetic process
DWG14_RS35330	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS35340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWG14_RS35345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DWG14_RS35350	COG0217	transcriptional regulatory protein
DWG14_RS35355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DWG14_RS35360	COG0632	four-way junction helicase activity
DWG14_RS35365	COG2255	four-way junction helicase activity
DWG14_RS35375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWG14_RS35380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWG14_RS35385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWG14_RS35395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWG14_RS35400	COG1196	nuclear chromosome segregation
DWG14_RS35405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DWG14_RS35415	COG0124	histidyl-tRNA synthetase
DWG14_RS35420	COG2197	response regulator
DWG14_RS35425	COG4585	Histidine kinase
DWG14_RS35435	COG1131	(ABC) transporter
DWG14_RS35450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWG14_RS35470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWG14_RS35475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWG14_RS35490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWG14_RS35495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWG14_RS35500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWG14_RS35505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWG14_RS35515	COG0006	proline dipeptidase activity
DWG14_RS35520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWG14_RS35525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWG14_RS35535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWG14_RS35540	COG0540	Belongs to the ATCase OTCase family
DWG14_RS35545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWG14_RS35555	COG0505	Belongs to the CarA family
DWG14_RS35560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWG14_RS35565	COG0167	dihydroorotate dehydrogenase activity
DWG14_RS35570	COG0284	orotidine-5'-phosphate decarboxylase activity
DWG14_RS35580	COG0194	GDP metabolic process
DWG14_RS35585	COG1758	RNA polymerase activity
DWG14_RS35595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWG14_RS35615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWG14_RS35630	COG2409	Drug exporters of the RND superfamily
DWG14_RS35635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWG14_RS35640	COG2390	Transcriptional regulator
DWG14_RS35650	COG0531	amino acid
DWG14_RS35665	COG2186	Transcriptional regulator
DWG14_RS35675	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWG14_RS35685	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DWG14_RS35690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWG14_RS35700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWG14_RS35720	COG2223	nitrite transmembrane transporter activity
DWG14_RS35725	COG1846	Transcriptional regulator
DWG14_RS35725	COG1940	carbohydrate kinase activity
DWG14_RS35735	COG3201	nicotinamide mononucleotide transporter
DWG14_RS35740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWG14_RS35740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWG14_RS35745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWG14_RS35750	COG0140	phosphoribosyl-ATP diphosphatase activity
DWG14_RS35755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DWG14_RS35805	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS35840	COG1216	Glycosyl transferase, family 2
DWG14_RS35855	COG2270	Major facilitator Superfamily
DWG14_RS35865	COG2364	Membrane
DWG14_RS35905	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS35910	COG2755	lipolytic protein G-D-S-L family
DWG14_RS35915	COG1984	allophanate hydrolase subunit 2
DWG14_RS35920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWG14_RS35925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DWG14_RS35930	COG4336	lyase activity
DWG14_RS35935	COG2814	Major facilitator Superfamily
DWG14_RS35985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWG14_RS35990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWG14_RS35995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWG14_RS36015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWG14_RS36025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWG14_RS36060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWG14_RS36080	COG1716	ATPase activity
DWG14_RS36100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWG14_RS36110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWG14_RS36110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWG14_RS36130	COG1175	transmembrane transport
DWG14_RS36135	COG0395	ABC-type sugar transport system, permease component
DWG14_RS36145	COG1609	Transcriptional regulator
DWG14_RS36195	COG1595	DNA-templated transcription, initiation
DWG14_RS36200	COG0657	acetylesterase activity
DWG14_RS36235	COG0697	spore germination
DWG14_RS36255	COG0583	DNA-binding transcription factor activity
DWG14_RS36295	COG0747	negative chemotaxis
DWG14_RS36300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWG14_RS36315	COG2318	DinB family
DWG14_RS36325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DWG14_RS36335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWG14_RS36350	COG1968	undecaprenyl-diphosphatase activity
DWG14_RS36360	COG0183	Belongs to the thiolase family
DWG14_RS36370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWG14_RS36390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWG14_RS36410	COG0110	maltose O-acetyltransferase activity
DWG14_RS36440	COG0640	Transcriptional regulator
DWG14_RS36450	COG0531	amino acid
DWG14_RS36455	COG1832	CoA-binding protein
DWG14_RS36470	COG1739	Uncharacterized protein family UPF0029
DWG14_RS36475	COG0420	3'-5' exonuclease activity
DWG14_RS36480	COG0419	ATPase involved in DNA repair
DWG14_RS36485	COG1522	sequence-specific DNA binding
DWG14_RS36510	COG0626	cystathionine gamma-synthase activity
DWG14_RS36535	COG0596	Alpha beta hydrolase
DWG14_RS36540	COG1595	DNA-templated transcription, initiation
DWG14_RS36545	COG2188	Transcriptional regulator
DWG14_RS36550	COG1940	carbohydrate kinase activity
DWG14_RS36555	COG2197	response regulator
DWG14_RS36560	COG4585	Histidine kinase
DWG14_RS36565	COG1131	(ABC) transporter
DWG14_RS36580	COG3663	DNA glycosylase
DWG14_RS36585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DWG14_RS36620	COG0577	efflux transmembrane transporter activity
DWG14_RS36620	COG1136	(ABC) transporter
DWG14_RS36625	COG1136	(ABC) transporter
DWG14_RS36640	COG2226	methyltransferase
DWG14_RS36645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DWG14_RS36655	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DWG14_RS36660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWG14_RS36665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DWG14_RS36700	COG1609	Transcriptional regulator
DWG14_RS36715	COG0800	Aldolase
DWG14_RS36720	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS36725	COG1063	alcohol dehydrogenase
DWG14_RS36735	COG3618	amidohydrolase
DWG14_RS36740	COG4948	Mandelate Racemase Muconate Lactonizing
DWG14_RS36750	COG1129	ABC transporter
DWG14_RS36775	COG0740	serine-type endopeptidase activity
DWG14_RS36790	COG1309	transcriptional regulator
DWG14_RS36795	COG0831	urea catabolic process
DWG14_RS36800	COG0832	Belongs to the urease beta subunit family
DWG14_RS36805	COG0804	urea catabolic process
DWG14_RS36815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DWG14_RS36820	COG0829	nickel cation binding
DWG14_RS36850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWG14_RS36855	COG1834	amidinotransferase
DWG14_RS36860	COG1522	sequence-specific DNA binding
DWG14_RS36865	COG3279	Response regulator of the LytR AlgR family
DWG14_RS36875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS36880	COG3275	phosphorelay sensor kinase activity
DWG14_RS36890	COG0515	serine threonine protein kinase
DWG14_RS36905	COG0205	6-phosphofructokinase activity
DWG14_RS36910	COG3442	glutamine amidotransferase
DWG14_RS36920	COG0242	peptide deformylase activity
DWG14_RS36930	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS36950	COG1793	dna ligase
DWG14_RS36955	COG0492	ferredoxin-NADP+ reductase activity
DWG14_RS36960	COG1396	sequence-specific DNA binding
DWG14_RS36960	COG3800	Transcriptional regulator
DWG14_RS36995	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS37000	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS37060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWG14_RS37070	COG2146	nitrite reductase [NAD(P)H] activity
DWG14_RS37075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWG14_RS37080	COG4638	Rieske (2fe-2S)
DWG14_RS37090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWG14_RS37095	COG1191	sigma factor activity
DWG14_RS37110	COG1366	Belongs to the anti-sigma-factor antagonist family
DWG14_RS37115	COG1366	Belongs to the anti-sigma-factor antagonist family
DWG14_RS37120	COG2172	sigma factor antagonist activity
DWG14_RS37150	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS37155	COG0517	IMP dehydrogenase activity
DWG14_RS37155	COG4175	Glycine betaine
DWG14_RS37160	COG4176	ABC-type proline glycine betaine transport system permease component
DWG14_RS37190	COG1414	Transcriptional regulator
DWG14_RS37200	COG1609	Transcriptional regulator
DWG14_RS37215	COG1653	transport
DWG14_RS37230	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DWG14_RS37230	COG3408	Glycogen debranching enzyme
DWG14_RS37240	COG0326	Molecular chaperone. Has ATPase activity
DWG14_RS37290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWG14_RS37295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWG14_RS37315	COG0477	Major facilitator Superfamily
DWG14_RS37325	COG2124	cytochrome p450
DWG14_RS37330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS37345	COG0702	epimerase
DWG14_RS37370	COG3345	alpha-galactosidase
DWG14_RS37400	COG3509	depolymerase
DWG14_RS37405	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS37425	COG1940	carbohydrate kinase activity
DWG14_RS37430	COG1070	Carbohydrate kinase
DWG14_RS37435	COG2115	Belongs to the xylose isomerase family
DWG14_RS37450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWG14_RS37455	COG3239	Fatty acid desaturase
DWG14_RS37530	COG2018	Roadblock/LC7 domain
DWG14_RS37540	COG1946	Acyl-CoA thioesterase
DWG14_RS37555	COG0254	rRNA binding
DWG14_RS37565	COG1132	(ABC) transporter
DWG14_RS37570	COG1132	(ABC) transporter
DWG14_RS37585	COG1301	dicarboxylic acid transport
DWG14_RS37595	COG1132	(ABC) transporter
DWG14_RS37620	COG1116	anion transmembrane transporter activity
DWG14_RS37625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWG14_RS37630	COG0432	Pfam Uncharacterised protein family UPF0047
DWG14_RS37635	COG3903	Transcriptional regulator
DWG14_RS37635	COG3629	intracellular signal transduction
DWG14_RS37700	COG2311	Membrane
DWG14_RS37710	COG0791	NLP P60 protein
DWG14_RS37750	COG3629	intracellular signal transduction
DWG14_RS37750	COG3903	Transcriptional regulator
DWG14_RS37780	COG1404	Belongs to the peptidase S8 family
DWG14_RS37790	COG0745	RESPONSE REGULATOR receiver
DWG14_RS37795	COG2205	protein histidine kinase activity
DWG14_RS37830	COG2207	Transcriptional regulator
DWG14_RS37830	COG1609	Transcriptional regulator
DWG14_RS37840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DWG14_RS37860	COG0714	Associated with various cellular activities
DWG14_RS37870	COG2124	cytochrome p450
DWG14_RS37880	COG0438	transferase activity, transferring glycosyl groups
DWG14_RS37890	COG0789	Transcriptional regulator
DWG14_RS37905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DWG14_RS37950	COG2319	Wd-40 repeat
DWG14_RS37950	COG4249	Peptidase C14 caspase catalytic subunit p20
DWG14_RS37955	COG4948	Mandelate Racemase Muconate Lactonizing
DWG14_RS37960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWG14_RS37965	COG0395	ABC-type sugar transport system, permease component
DWG14_RS37970	COG1175	transmembrane transport
DWG14_RS37975	COG1653	transport
DWG14_RS38015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWG14_RS38045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWG14_RS38075	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWG14_RS38100	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS38120	COG3509	depolymerase
DWG14_RS38125	COG1902	pentaerythritol trinitrate reductase activity
DWG14_RS38130	COG0640	Transcriptional regulator
DWG14_RS38160	COG1309	transcriptional regulator
DWG14_RS38210	COG0584	glycerophosphoryl diester phosphodiesterase
DWG14_RS38245	COG0204	Acyl-transferase
DWG14_RS38270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DWG14_RS38285	COG0515	serine threonine protein kinase
DWG14_RS38310	COG1660	Displays ATPase and GTPase activities
DWG14_RS38315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWG14_RS38320	COG0747	negative chemotaxis
DWG14_RS38325	COG0601	transmembrane transport
DWG14_RS38335	COG4608	Belongs to the ABC transporter superfamily
DWG14_RS38355	COG0445	tRNA wobble uridine modification
DWG14_RS38370	COG4585	Histidine kinase
DWG14_RS38375	COG2197	response regulator
DWG14_RS38425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWG14_RS38430	COG2223	nitrite transmembrane transporter activity
DWG14_RS38445	COG2610	gluconate transmembrane transporter activity
DWG14_RS38450	COG1228	amidohydrolase
DWG14_RS38475	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWG14_RS38475	COG0515	serine threonine protein kinase
DWG14_RS38490	COG1653	transport
DWG14_RS38510	COG0584	glycerophosphoryl diester phosphodiesterase
DWG14_RS38520	COG2409	Drug exporters of the RND superfamily
DWG14_RS38525	COG0667	Aldo Keto reductase
DWG14_RS38530	COG2207	Transcriptional regulator
DWG14_RS38535	COG1703	isobutyryl-CoA mutase activity
DWG14_RS38535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS38535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWG14_RS38565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWG14_RS38570	COG4608	Belongs to the ABC transporter superfamily
DWG14_RS38575	COG0444	Belongs to the ABC transporter superfamily
DWG14_RS38595	COG2267	carboxylic ester hydrolase activity
DWG14_RS38600	COG2186	Transcriptional regulator
DWG14_RS38610	COG2814	Major facilitator Superfamily
DWG14_RS38620	COG1609	Transcriptional regulator
DWG14_RS38685	COG3387	PFAM Glycoside hydrolase 15-related
DWG14_RS38690	COG1349	DNA-binding transcription factor activity
DWG14_RS38695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWG14_RS38700	COG0191	fructose-bisphosphate aldolase activity
DWG14_RS38710	COG2813	Specifically methylates the guanine in position
DWG14_RS38720	COG1940	carbohydrate kinase activity
DWG14_RS38795	COG1733	regulation of RNA biosynthetic process
DWG14_RS38810	COG1349	DNA-binding transcription factor activity
DWG14_RS38845	COG1215	transferase activity, transferring glycosyl groups
DWG14_RS38850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DWG14_RS38875	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS38915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWG14_RS38920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWG14_RS38925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWG14_RS38935	COG2376	Dihydroxyacetone kinase
DWG14_RS38940	COG1408	metallophosphoesterase
DWG14_RS38950	COG1609	Transcriptional regulator
DWG14_RS38965	COG0395	ABC-type sugar transport system, permease component
DWG14_RS38970	COG3250	beta-galactosidase activity
DWG14_RS38990	COG1940	carbohydrate kinase activity
DWG14_RS38995	COG2182	Extracellular solute-binding protein
DWG14_RS39000	COG1175	transmembrane transport
DWG14_RS39005	COG0395	ABC-type sugar transport system, permease component
DWG14_RS39010	COG2723	6-phospho-beta-galactosidase activity
DWG14_RS39020	COG2814	Major facilitator Superfamily
DWG14_RS39030	COG1090	epimerase
DWG14_RS39045	COG0395	ABC-type sugar transport system, permease component
DWG14_RS39050	COG1175	transmembrane transport
DWG14_RS39055	COG1653	transport
DWG14_RS39075	COG0640	Transcriptional regulator
DWG14_RS39085	COG1316	TRANSCRIPTIONal
DWG14_RS39090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWG14_RS39105	COG2197	response regulator
DWG14_RS39115	COG1129	ABC transporter
DWG14_RS39130	COG0667	Aldo Keto reductase
DWG14_RS39140	COG0592	DNA-directed DNA polymerase activity
DWG14_RS39200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWG14_RS39205	COG1993	acr, cog1993
DWG14_RS39210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWG14_RS39215	COG1968	undecaprenyl-diphosphatase activity
DWG14_RS39220	COG2186	Transcriptional regulator
DWG14_RS39225	COG1113	amino acid transport
DWG14_RS39240	COG2066	Belongs to the glutaminase family
DWG14_RS39250	COG1051	belongs to the nudix hydrolase family
DWG14_RS39255	COG1686	Belongs to the peptidase S11 family
DWG14_RS39260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWG14_RS39265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWG14_RS39270	COG3795	YCII-related domain
DWG14_RS39280	COG4941	Belongs to the sigma-70 factor family
DWG14_RS39290	COG1695	Transcriptional regulator
DWG14_RS39295	COG2226	methyltransferase
DWG14_RS39305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS39310	COG3458	cephalosporin-C deacetylase activity
DWG14_RS39325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWG14_RS39345	COG2890	protein-(glutamine-N5) methyltransferase activity
DWG14_RS39370	COG0475	glutathione-regulated potassium exporter activity
DWG14_RS39395	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWG14_RS39395	COG1902	pentaerythritol trinitrate reductase activity
DWG14_RS39420	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DWG14_RS39425	COG1461	Dihydroxyacetone kinase
DWG14_RS39430	COG2376	Dihydroxyacetone kinase
DWG14_RS39465	COG3387	PFAM Glycoside hydrolase 15-related
DWG14_RS39480	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS39490	COG0515	serine threonine protein kinase
DWG14_RS39500	COG2070	2-Nitropropane dioxygenase
DWG14_RS39510	COG2366	antibiotic biosynthetic process
DWG14_RS39515	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS39520	COG0596	Alpha beta hydrolase
DWG14_RS39535	COG1024	Enoyl-CoA hydratase
DWG14_RS39575	COG2319	Wd-40 repeat
DWG14_RS39575	COG4249	Peptidase C14 caspase catalytic subunit p20
DWG14_RS39635	COG2814	Major facilitator Superfamily
DWG14_RS39670	COG1595	DNA-templated transcription, initiation
DWG14_RS39685	COG0702	epimerase
DWG14_RS39690	COG1846	Transcriptional regulator
DWG14_RS39695	COG2409	Drug exporters of the RND superfamily
DWG14_RS39725	COG0431	NADPH-dependent FMN reductase
DWG14_RS39750	COG4941	Belongs to the sigma-70 factor family
DWG14_RS39755	COG1012	belongs to the aldehyde dehydrogenase family
DWG14_RS39775	COG1414	Transcriptional regulator
DWG14_RS39780	COG1082	Xylose isomerase domain protein TIM barrel
DWG14_RS39780	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DWG14_RS39785	COG0667	Aldo Keto reductase
DWG14_RS39800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWG14_RS39805	COG0412	Dienelactone hydrolase
DWG14_RS39810	COG0346	lactoylglutathione lyase activity
DWG14_RS39815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWG14_RS39830	COG0583	DNA-binding transcription factor activity
DWG14_RS39835	COG0667	Aldo Keto reductase
DWG14_RS39850	COG0842	Transport permease protein
DWG14_RS39850	COG1716	ATPase activity
DWG14_RS39850	COG1131	(ABC) transporter
DWG14_RS39885	COG1191	sigma factor activity
DWG14_RS39895	COG0740	serine-type endopeptidase activity
DWG14_RS39900	COG0740	serine-type endopeptidase activity
DWG14_RS39905	COG0596	Alpha beta hydrolase
DWG14_RS39930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWG14_RS39940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWG14_RS39950	COG0328	RNA-DNA hybrid ribonuclease activity
DWG14_RS39975	COG0477	Major facilitator Superfamily
DWG14_RS39990	COG0667	Aldo Keto reductase
DWG14_RS40000	COG3647	Membrane
DWG14_RS40015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWG14_RS40025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWG14_RS40025	COG0515	serine threonine protein kinase
DWG14_RS40030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWG14_RS40050	COG2340	Cysteine-rich secretory protein family
DWG14_RS40060	COG1940	carbohydrate kinase activity
DWG14_RS40060	COG1846	Transcriptional regulator
DWG14_RS40065	COG3345	alpha-galactosidase
DWG14_RS40080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWG14_RS40080	COG1672	PFAM Archaeal ATPase
DWG14_RS40090	COG3852	Histidine kinase
DWG14_RS40095	COG0492	ferredoxin-NADP+ reductase activity
DWG14_RS40115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWG14_RS40150	COG0745	RESPONSE REGULATOR receiver
DWG14_RS40155	COG5002	protein histidine kinase activity
DWG14_RS40190	COG0477	Major facilitator Superfamily
DWG14_RS40245	COG1252	NADH dehydrogenase
DWG14_RS40270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWG14_RS40275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DWG14_RS40280	COG3281	Trehalose synthase
DWG14_RS40290	COG0366	Alpha amylase catalytic
DWG14_RS40320	COG1191	sigma factor activity
DWG14_RS40335	COG0842	Transport permease protein
DWG14_RS40345	COG0181	hydroxymethylbilane synthase activity
DWG14_RS40350	COG2814	Major facilitator Superfamily
DWG14_RS40380	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS40400	COG0477	Major facilitator Superfamily
DWG14_RS40440	COG0656	L-ascorbic acid biosynthetic process
DWG14_RS40445	COG1609	Transcriptional regulator
DWG14_RS40455	COG0395	ABC-type sugar transport system, permease component
DWG14_RS40460	COG1175	transmembrane transport
DWG14_RS40495	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS40505	COG0842	Transport permease protein
DWG14_RS40540	COG0009	L-threonylcarbamoyladenylate synthase
DWG14_RS40570	COG2197	response regulator
DWG14_RS40575	COG4585	Histidine kinase
DWG14_RS40580	COG1136	(ABC) transporter
DWG14_RS40590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWG14_RS40625	COG3321	synthase
DWG14_RS40625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWG14_RS40630	COG0318	PFAM AMP-dependent synthetase and ligase
DWG14_RS40635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWG14_RS40645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS40655	COG2124	cytochrome p450
DWG14_RS40685	COG3833	ABC-type maltose transport systems, permease component
DWG14_RS40695	COG1653	transport
DWG14_RS40705	COG2409	Drug exporters of the RND superfamily
DWG14_RS40710	COG4585	Histidine kinase
DWG14_RS40715	COG2197	response regulator
DWG14_RS40800	COG3903	Transcriptional regulator
DWG14_RS40800	COG3629	intracellular signal transduction
DWG14_RS40810	COG0667	Aldo Keto reductase
DWG14_RS40835	COG4251	negative regulation of phosphorylation
DWG14_RS40840	COG0784	Response regulator, receiver
DWG14_RS40880	COG0753	catalase activity
DWG14_RS40885	COG1597	lipid kinase activity
DWG14_RS40945	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWG14_RS40945	COG2308	Evidence 4 Homologs of previously reported genes of
DWG14_RS40950	COG0367	asparagine synthase
DWG14_RS40960	COG1982	Orn Lys Arg decarboxylase major
DWG14_RS40965	COG0514	ATP-dependent DNA helicase (RecQ)
DWG14_RS40975	COG5002	protein histidine kinase activity
DWG14_RS40975	COG2205	protein histidine kinase activity
DWG14_RS40975	COG0784	Response regulator, receiver
DWG14_RS40980	COG1366	Belongs to the anti-sigma-factor antagonist family
DWG14_RS40990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWG14_RS40995	COG0738	Major facilitator superfamily
DWG14_RS41000	COG3226	Transcriptional regulator
DWG14_RS41015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWG14_RS41030	COG1191	sigma factor activity
DWG14_RS41045	COG2261	transglycosylase associated protein
DWG14_RS41055	COG0402	S-adenosylhomocysteine deaminase activity
DWG14_RS41060	COG0657	acetylesterase activity
DWG14_RS41065	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWG14_RS41080	COG0583	DNA-binding transcription factor activity
DWG14_RS41085	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS41095	COG1024	Enoyl-CoA hydratase
DWG14_RS41125	COG0183	Belongs to the thiolase family
DWG14_RS41130	COG1309	transcriptional regulator
DWG14_RS41135	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS41140	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS41145	COG1960	acyl-CoA dehydrogenase activity
DWG14_RS41160	COG2814	Major facilitator Superfamily
DWG14_RS41220	COG1609	Transcriptional regulator
DWG14_RS41230	COG3507	Belongs to the glycosyl hydrolase 43 family
DWG14_RS41250	COG0667	Aldo Keto reductase
DWG14_RS41260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DWG14_RS41265	COG2186	Transcriptional regulator
DWG14_RS41275	COG3875	lactate racemase activity
DWG14_RS41280	COG1691	(AIR) carboxylase
DWG14_RS41285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DWG14_RS41290	COG1606	tRNA processing
DWG14_RS41320	COG0800	Aldolase
DWG14_RS41325	COG1028	Short-chain dehydrogenase reductase Sdr
DWG14_RS41330	COG1063	alcohol dehydrogenase
DWG14_RS41335	COG3618	amidohydrolase
DWG14_RS41350	COG0395	ABC-type sugar transport system, permease component
DWG14_RS41355	COG1175	transmembrane transport
DWG14_RS41365	COG2186	Transcriptional regulator
DWG14_RS41405	COG0395	ABC-type sugar transport system, permease component
DWG14_RS41410	COG1175	transmembrane transport
DWG14_RS41445	COG2318	DinB family
DWG14_RS41460	COG3655	Transcriptional regulator
DWG14_RS41475	COG1609	Transcriptional regulator
DWG14_RS41490	COG0395	ABC-type sugar transport system, permease component
DWG14_RS41545	COG5520	Belongs to the glycosyl hydrolase 30 family
DWG14_RS41595	COG4171	peptide transport system, permease
DWG14_RS41605	COG0747	negative chemotaxis
DWG14_RS41620	COG0019	diaminopimelate decarboxylase activity
DWG14_RS41625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWG14_RS41630	COG0534	Mate efflux family protein
DWG14_RS41655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWG14_RS41670	COG2197	response regulator
DWG14_RS41740	COG2208	phosphoserine phosphatase activity
DWG14_RS41740	COG2770	Histidine kinase
DWG14_RS41760	COG3844	kynureninase activity
DWG14_RS41765	COG1113	amino acid transport
DWG14_RS41775	COG3971	2-oxopent-4-enoate hydratase activity
DWG14_RS41780	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DWG14_RS41785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWG14_RS41800	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
DWG14_RS41830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DWG14_RS41850	COG1940	carbohydrate kinase activity
DWG14_RS41855	COG1129	ABC transporter
DWG14_RS41860	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWG14_RS41870	COG0673	inositol 2-dehydrogenase activity
DWG14_RS41910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWG14_RS41925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWG14_RS41935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWG14_RS41940	COG2197	response regulator
DWG14_RS41945	COG3851	Histidine kinase
DWG14_RS41950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DWG14_RS41985	COG3485	protocatechuate 3,4-dioxygenase
DWG14_RS41990	COG0300	oxidoreductase activity
DWG14_RS42005	COG3693	PFAM glycoside hydrolase, family 10
DWG14_RS42045	COG2326	polyphosphate kinase activity
DWG14_RS42075	COG0517	IMP dehydrogenase activity
DWG14_RS42075	COG0516	GMP reductase activity
DWG14_RS42110	COG3835	regulator
DWG14_RS42125	COG4989	oxidoreductase activity
DWG14_RS42135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWG14_RS42140	COG0254	rRNA binding
DWG14_RS42175	COG0583	DNA-binding transcription factor activity
DWG14_RS42200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWG14_RS42210	COG0739	heme binding
DWG14_RS42220	COG1309	transcriptional regulator
DWG14_RS42240	COG0583	DNA-binding transcription factor activity
DWG14_RS42255	COG1335	isochorismatase
DWG14_RS42265	COG0583	DNA-binding transcription factor activity
DWG14_RS42330	COG0477	Major facilitator Superfamily
DWG14_RS42385	COG3250	beta-galactosidase activity
DWG14_RS42395	COG0488	(ABC) transporter
DWG14_RS42400	COG0488	(ABC) transporter
DWG14_RS42415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DWG14_RS42430	COG1073	alpha beta
DWG14_RS42445	COG4249	Peptidase C14 caspase catalytic subunit p20
DWG14_RS42445	COG2319	Wd-40 repeat
DWG14_RS42495	COG2409	Drug exporters of the RND superfamily
DWG14_RS42500	COG0395	ABC-type sugar transport system, permease component
DWG14_RS42505	COG1175	transmembrane transport
DWG14_RS42510	COG2182	Extracellular solute-binding protein
DWG14_RS42555	COG1216	Glycosyl transferase, family 2
DWG14_RS42565	COG0529	Catalyzes the synthesis of activated sulfate
DWG14_RS42575	COG4733	cellulase activity
DWG14_RS42575	COG5297	Belongs to the glycosyl hydrolase family 6
DWG14_RS42665	COG1028	Short-chain dehydrogenase reductase Sdr