locus-tag class description DDJ31_RS00005 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 DDJ31_RS00010 ENOG4105CPP Dehydrogenase, E1 component DDJ31_RS00030 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS00060 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) DDJ31_RS00105 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DDJ31_RS00125 ENOG4105DTI Phosphonopyruvate decarboxylase DDJ31_RS00215 ENOG4105CSH Transporter DDJ31_RS00220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DDJ31_RS00225 ENOG4105E39 Enoyl-CoA hydratase DDJ31_RS00230 ENOG4106NZI LysR family Transcriptional regulator DDJ31_RS00265 ENOG4105CJA serine threonine protein kinase DDJ31_RS00290 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DDJ31_RS00325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS00345 ENOG4105CPC Aldo Keto reductase DDJ31_RS00350 ENOG4105KHC sulfurtransferase DDJ31_RS00360 ENOG4105CVN desaturase DDJ31_RS00400 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DDJ31_RS00415 ENOG4107HP6 Transcriptional regulator DDJ31_RS00420 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DDJ31_RS00430 ENOG4105EG2 ABC transporter, permease DDJ31_RS00460 ENOG4105BZU Histidine kinase DDJ31_RS00465 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS00475 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DDJ31_RS00500 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS00510 ENOG4105JZI cytochrome P450 DDJ31_RS00520 ENOG4107SQU synthase DDJ31_RS00540 ENOG4108RVA ribokinase DDJ31_RS00545 ENOG4105CNN ABC, transporter DDJ31_RS00555 ENOG4105C2J ABC transporter DDJ31_RS00560 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DDJ31_RS00565 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DDJ31_RS00600 ENOG4105F27 Major Facilitator DDJ31_RS00625 ENOG4105E98 transcriptional regulator DeoR family DDJ31_RS00630 ENOG4105E98 transcriptional regulator DeoR family DDJ31_RS00635 ENOG4106NZI LysR family Transcriptional regulator DDJ31_RS00675 ENOG4105CSH Transporter DDJ31_RS00700 ENOG4108VGI doxx family DDJ31_RS00710 ENOG4105C2D reductase DDJ31_RS00720 ENOG4105CXK mandelate racemase muconate lactonizing DDJ31_RS00725 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DDJ31_RS00730 ENOG4107HP6 Transcriptional regulator DDJ31_RS00750 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component DDJ31_RS00755 ENOG4105DRS transport system, permease DDJ31_RS00775 ENOG4105ERH Fumarylacetoacetate hydrolase DDJ31_RS00785 ENOG4105EBR Carboxylesterase DDJ31_RS00795 ENOG4107RBJ symporter DDJ31_RS00800 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS00815 ENOG41087PP glycosyltransferase MGT family DDJ31_RS00825 ENOG4107T94 Endo-14-beta-xylanase DDJ31_RS00850 ENOG4105DQE DNA ligase DDJ31_RS00865 ENOG4108638 50S ribosomal protein L36 DDJ31_RS00870 ENOG4105NRA 50s ribosomal protein l31 type b DDJ31_RS00875 ENOG4105W0E 50S ribosomal protein L33 DDJ31_RS00885 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DDJ31_RS00935 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS00940 ENOG4105F38 ABC transporter, permease DDJ31_RS00945 ENOG4105D38 putrescine abc transporter DDJ31_RS00950 ENOG4108IGT Dipeptidase DDJ31_RS01020 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DDJ31_RS01040 ENOG4106A3M Cytochrome p-450 DDJ31_RS01055 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DDJ31_RS01060 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS01070 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DDJ31_RS01090 ENOG4105C09 Bile acid DDJ31_RS01100 ENOG4105Q56 cytochrome P450 DDJ31_RS01120 ENOG4105C8Y Acetylornithine aminotransferase DDJ31_RS01150 ENOG4105CSH Transporter DDJ31_RS01165 ENOG4105C7B Threonine dehydratase DDJ31_RS01170 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS01180 ENOG4105WQT MbtH domain protein DDJ31_RS01190 ENOG4105EC3 peptidase S51, dipeptidase E DDJ31_RS01195 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS01200 ENOG4108S01 response regulator DDJ31_RS01215 ENOG4107SM8 Adenylate Guanylate cyclase DDJ31_RS01225 ENOG4106A3M Cytochrome p-450 DDJ31_RS01280 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DDJ31_RS01285 ENOG4107S5I aldo keto reductase DDJ31_RS01290 ENOG4105DME alpha-galactosidase DDJ31_RS01295 ENOG4108TFM Kinase, PfkB family DDJ31_RS01305 ENOG4108KD5 ADP-ribosylation crystallin J1 DDJ31_RS01310 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS01325 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) DDJ31_RS01340 ENOG4106UDK Cellulose-binding, family II DDJ31_RS01355 ENOG4105C26 Dehydrogenase DDJ31_RS01360 ENOG4107QPD alcohol dehydrogenase DDJ31_RS01375 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS01380 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DDJ31_RS01405 ENOG4105DQ5 transport system permease protein DDJ31_RS01410 ENOG4105TVJ transport system, permease DDJ31_RS01415 ENOG4105E0A ABC, transporter DDJ31_RS01450 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) DDJ31_RS01460 ENOG4105E98 transcriptional regulator DeoR family DDJ31_RS01465 ENOG4106UW1 Major Facilitator superfamily DDJ31_RS01500 ENOG4105ECQ AraC Family Transcriptional Regulator DDJ31_RS01510 ENOG4105KT7 mgtC SapB transporter DDJ31_RS01515 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS01520 ENOG4105CNT hydrolase family 2 DDJ31_RS01530 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DDJ31_RS01535 ENOG4105DRS transport system, permease DDJ31_RS01545 ENOG4105EGE secreted protein DDJ31_RS01585 ENOG4108JQ7 (ABC) transporter DDJ31_RS01590 ENOG4105C3U ABC transporter DDJ31_RS01595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS01600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DDJ31_RS01605 ENOG4107QSI ABC, transporter DDJ31_RS01635 ENOG4105ECY inositol monophosphatase DDJ31_RS01670 ENOG4105CSH Transporter DDJ31_RS01680 ENOG4105Q26 Siderophore-interacting protein DDJ31_RS01700 ENOG4105DQ5 transport system permease protein DDJ31_RS01705 ENOG4105TVJ transport system, permease DDJ31_RS01715 ENOG4105E0A ABC, transporter DDJ31_RS01720 ENOG4108HUF Transporter DDJ31_RS01740 ENOG4106J7G oxidoreductase DDJ31_RS01745 ENOG4108KFM Xylose Isomerase Domain-Containing protein DDJ31_RS01750 ENOG4105CP7 Triose-phosphate isomerase DDJ31_RS01760 ENOG4105CMT Dihydroxyacetone kinase DDJ31_RS01770 ENOG4105JXH GntR family transcriptional regulator DDJ31_RS01775 ENOG4105BZU Histidine kinase DDJ31_RS01780 ENOG4107U9T Pfam:Ribonuclease_BN DDJ31_RS01800 ENOG4105VBF alkaline shock protein DDJ31_RS01835 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DDJ31_RS01840 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DDJ31_RS01850 ENOG4105RNG membrane DDJ31_RS01855 ENOG4105K6V RNA polymerase DDJ31_RS01870 ENOG4105CSA Coproporphyrinogen iii oxidase DDJ31_RS01920 ENOG4105DQ5 transport system permease protein DDJ31_RS01925 ENOG4105TVJ transport system, permease DDJ31_RS01950 ENOG4105MKU Transcriptional regulator DDJ31_RS01960 ENOG4106T9R serine protease DDJ31_RS02005 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS02025 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DDJ31_RS02075 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) DDJ31_RS02090 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DDJ31_RS02110 ENOG4105WN5 stage II sporulation protein DDJ31_RS02150 ENOG4107MMM Anti-sigma-factor antagonist DDJ31_RS02155 ENOG4105FUA antagonist DDJ31_RS02175 ENOG4105CEP NADH dehydrogenase DDJ31_RS02200 ENOG4105E8G Major facilitator Superfamily DDJ31_RS02230 ENOG4105BZU Histidine kinase DDJ31_RS02235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS02330 ENOG4105K4I Scp-like extracellular DDJ31_RS02345 ENOG4107QPV Serine Threonine protein kinase DDJ31_RS02350 ENOG41066YJ Beta-lactamase DDJ31_RS02360 ENOG4108R5S membrane DDJ31_RS02365 ENOG4107SET aldo keto reductase DDJ31_RS02385 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DDJ31_RS02400 ENOG4105U5Y Transcriptional regulator DDJ31_RS02415 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DDJ31_RS02420 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DDJ31_RS02425 ENOG4105WBV Transcriptional regulator DDJ31_RS02430 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DDJ31_RS02435 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS02455 ENOG4105CPC Aldo Keto reductase DDJ31_RS02460 ENOG4108M0I Transcriptional regulator DDJ31_RS02475 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DDJ31_RS02480 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase DDJ31_RS02485 ENOG4107S5I aldo keto reductase DDJ31_RS02495 ENOG4108VQR secreted hydrolase DDJ31_RS02500 ENOG4105C26 Dehydrogenase DDJ31_RS02505 ENOG4105CHP RNA polymerase DDJ31_RS02520 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DDJ31_RS02535 ENOG4107RSM transcriptional regulator DDJ31_RS02550 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS02570 ENOG4105CVP deoxyribo-dipyrimidine photolyase DDJ31_RS02590 ENOG4105K6V RNA polymerase DDJ31_RS02640 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DDJ31_RS02675 ENOG4108YV4 Universal stress protein DDJ31_RS02700 ENOG4105E39 Enoyl-CoA hydratase DDJ31_RS02705 ENOG41080W3 amp-dependent synthetase and ligase DDJ31_RS02720 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS02785 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DDJ31_RS02790 ENOG4105X7H acyl-CoA dehydrogenase DDJ31_RS02805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DDJ31_RS02845 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DDJ31_RS02855 ENOG4108IMY Transcriptional regulator DDJ31_RS02875 ENOG4105CMT Dihydroxyacetone kinase DDJ31_RS02880 ENOG4108UTZ Dihydroxyacetone kinase DDJ31_RS02895 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DDJ31_RS02905 ENOG4105CYP glycoside hydrolase, family DDJ31_RS02920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DDJ31_RS02940 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DDJ31_RS02980 ENOG4105I82 acetyl xylan esterase DDJ31_RS02985 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS03000 ENOG4105DYW oxidoreductase DDJ31_RS03025 ENOG4106A3M Cytochrome p-450 DDJ31_RS03035 ENOG4105DZ1 carboxypeptidase DDJ31_RS03040 ENOG41090CE integral membrane protein DDJ31_RS03045 ENOG4105CSV Glutaminase DDJ31_RS03050 ENOG4108IJ0 Aspartate ammonia-lyase DDJ31_RS03065 ENOG41073TP transcriptional regulator DDJ31_RS03070 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DDJ31_RS03080 ENOG4105KJJ Uncharacterized ACR, COG1993 DDJ31_RS03085 ENOG41083YR Protein CrcB homolog DDJ31_RS03095 ENOG41064MX Tetr family transcriptional regulator DDJ31_RS03110 ENOG4108JQ1 Dehydrogenase DDJ31_RS03125 ENOG4105CIF Ornithine Cyclodeaminase DDJ31_RS03145 ENOG4105CPF Cell wall formation (By similarity) DDJ31_RS03150 ENOG4107REC cytoplasmic protein DDJ31_RS03155 ENOG4105F27 Major Facilitator DDJ31_RS03170 ENOG41064MX Tetr family transcriptional regulator DDJ31_RS03195 ENOG4105D56 permease protein DDJ31_RS03205 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS03215 ENOG41067TZ transcriptional regulator, MarR family DDJ31_RS03260 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr DDJ31_RS03275 ENOG4107VHA regulatoR DDJ31_RS03325 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DDJ31_RS03365 ENOG4105MVE transcriptional regulator DDJ31_RS03390 ENOG4108YZG isomerase DDJ31_RS03395 ENOG4105DKQ ROK family DDJ31_RS03405 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) DDJ31_RS03415 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DDJ31_RS03420 ENOG4105E98 transcriptional regulator DeoR family DDJ31_RS03425 ENOG4105BZP glycoside hydrolase 15-related DDJ31_RS03430 ENOG4105EFZ amidohydrolase DDJ31_RS03435 ENOG4105WQI isochorismatase DDJ31_RS03460 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS03480 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DDJ31_RS03500 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DDJ31_RS03505 ENOG4105DQ5 transport system permease protein DDJ31_RS03510 ENOG4105TVJ transport system, permease DDJ31_RS03535 ENOG4105MWK D-amino acid dehydrogenase, small subunit DDJ31_RS03545 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DDJ31_RS03550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DDJ31_RS03555 ENOG4105CTU Proline racemase DDJ31_RS03565 ENOG4106UDK Cellulose-binding, family II DDJ31_RS03570 ENOG4105EGE secreted protein DDJ31_RS03590 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DDJ31_RS03610 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDJ31_RS03620 ENOG4105C6Y Udp-glucose 6-dehydrogenase DDJ31_RS03630 ENOG4105C3M thioredoxin reductase DDJ31_RS03635 ENOG4107PP3 Acetylornithine deacetylase DDJ31_RS03640 ENOG4105I1F Resistance protein DDJ31_RS03655 ENOG41060NJ transcriptional regulator DDJ31_RS03670 ENOG4105C10 Electron transfer flavoprotein DDJ31_RS03675 ENOG4105BZJ Electron transfer flavoprotein DDJ31_RS03695 ENOG4105PSQ Acyl-transferase DDJ31_RS03720 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DDJ31_RS03755 ENOG410841Q phosphoesterase PA-phosphatase related protein DDJ31_RS03765 ENOG41082JN Transcriptional regulator DDJ31_RS03790 ENOG4105YVS arsR family transcriptional regulator DDJ31_RS03795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DDJ31_RS03800 ENOG4107S46 esterase, PHB depolymerase DDJ31_RS03820 ENOG4105CSU acyl-Coa dehydrogenase DDJ31_RS03835 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DDJ31_RS03885 ENOG4105K4H Nlp p60 protein DDJ31_RS03900 ENOG4105EQX glucarate dehydratase DDJ31_RS03905 ENOG4105DZ2 Transcriptional regulator DDJ31_RS03920 ENOG4108YYQ gCN5-related N-acetyltransferase DDJ31_RS03945 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DDJ31_RS03960 ENOG4105CHR reductase DDJ31_RS03970 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DDJ31_RS03990 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS04020 ENOG4105CC5 ABC transporter DDJ31_RS04025 ENOG4105DIK (ABC) transporter DDJ31_RS04030 ENOG4105E0A ABC, transporter DDJ31_RS04035 ENOG4105EHG Permease protein DDJ31_RS04070 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DDJ31_RS04085 ENOG4105EYF MMPL domain protein DDJ31_RS04100 ENOG4107ZED Uncharacterised protein family UPF0047 DDJ31_RS04105 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DDJ31_RS04110 ENOG4105E2Y ABC, transporter DDJ31_RS04120 ENOG4105H3G oxidoreductase DDJ31_RS04130 ENOG4105BZ1 (ABC) transporter DDJ31_RS04135 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DDJ31_RS04140 ENOG4105CK2 sodium dicarboxylate symporter DDJ31_RS04160 ENOG4105BZ1 (ABC) transporter DDJ31_RS04170 ENOG4105NRA 50s ribosomal protein l31 type b DDJ31_RS04185 ENOG4105C29 acyl-CoA thioesterase DDJ31_RS04195 ENOG4105GWZ Roadblock lc7 family protein DDJ31_RS04235 ENOG4105CMG Carbohydrate kinase DDJ31_RS04240 ENOG4105E2R ROK family DDJ31_RS04250 ENOG4107RR1 TRANSCRIPTIONal DDJ31_RS04260 ENOG4105C26 Dehydrogenase DDJ31_RS04285 ENOG4105CY0 Metallo-Beta-Lactamase DDJ31_RS04300 ENOG41086D8 Transcriptional regulator DDJ31_RS04340 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DDJ31_RS04370 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) DDJ31_RS04405 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS04410 ENOG4105CPQ Dehydrogenase DDJ31_RS04415 ENOG4105EV8 ectoine hydroxylase DDJ31_RS04430 ENOG4105JAB phenazine biosynthesis protein, phzf family DDJ31_RS04445 ENOG4105KG1 l-proline 3-hydroxylase DDJ31_RS04490 ENOG4105E8R UPF0173 metal-dependent hydrolase DDJ31_RS04500 ENOG4108I69 Glycosyl transferases group 1 DDJ31_RS04560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DDJ31_RS04565 ENOG4105J7D transcriptional regulator DDJ31_RS04600 ENOG4105C8Y Acetylornithine aminotransferase DDJ31_RS04635 ENOG4105D74 hydrolase DDJ31_RS04660 ENOG4105C26 Dehydrogenase DDJ31_RS04670 ENOG4105G2Y Transcriptional regulator DDJ31_RS04675 ENOG4105ECY inositol monophosphatase DDJ31_RS04690 ENOG4108WUH Transcriptional regulator, TetR family DDJ31_RS04740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DDJ31_RS04760 ENOG41073TP transcriptional regulator DDJ31_RS04780 ENOG4105DIA mandelate racemase muconate lactonizing DDJ31_RS04785 ENOG4105ERH Fumarylacetoacetate hydrolase DDJ31_RS04795 ENOG4107T3P ABC, transporter DDJ31_RS04800 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component DDJ31_RS04850 ENOG4107VFM Dehydrogenase DDJ31_RS04935 ENOG4105EC2 ftsk spoIIIe DDJ31_RS04940 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin DDJ31_RS04945 ENOG4106F1P AAA ATPase, central domain protein DDJ31_RS04970 ENOG41082AN stage II sporulation protein DDJ31_RS04975 ENOG4107MMM Anti-sigma-factor antagonist DDJ31_RS04980 ENOG4105FUA antagonist DDJ31_RS04985 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DDJ31_RS04995 ENOG4105BZU Histidine kinase DDJ31_RS05000 ENOG4108UXN response regulator DDJ31_RS05055 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DDJ31_RS05070 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS05095 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS05165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DDJ31_RS05230 ENOG4105C0K Gdp-mannose 4,6-dehydratase DDJ31_RS05240 ENOG4105DQ5 transport system permease protein DDJ31_RS05245 ENOG4105TVJ transport system, permease DDJ31_RS05250 ENOG4105CHH sulfate transporter DDJ31_RS05255 ENOG4107TXC Transcriptional regulator DDJ31_RS05270 ENOG4105DRS transport system, permease DDJ31_RS05275 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DDJ31_RS05295 ENOG4105F27 Major Facilitator DDJ31_RS05305 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS05320 ENOG4105D3W isochorismatase DDJ31_RS05340 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) DDJ31_RS05350 ENOG4105E0A ABC, transporter DDJ31_RS05355 ENOG4105EHG Permease protein DDJ31_RS05375 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DDJ31_RS05400 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS05405 ENOG4105D2B acyl-CoA dehydrogenase DDJ31_RS05410 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DDJ31_RS05425 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) DDJ31_RS05450 ENOG41065KQ synthase DDJ31_RS05455 ENOG4106A3M Cytochrome p-450 DDJ31_RS05465 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS05475 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DDJ31_RS05485 ENOG4105F1K Glutamine amidotransferase DDJ31_RS05490 ENOG4105CTQ phosphohexokinase DDJ31_RS05505 ENOG4108HRK Histidine kinase DDJ31_RS05520 ENOG4108NEV two component transcriptional regulator, LytTR family DDJ31_RS05530 ENOG4105CIK Amidinotransferase DDJ31_RS05535 ENOG4105C8Y Acetylornithine aminotransferase DDJ31_RS05580 ENOG4105CQM Urea amidohydrolase subunit alpha DDJ31_RS05585 ENOG4105KI2 Urea amidohydrolase subunit beta DDJ31_RS05590 ENOG4108YZ9 Urea amidohydrolase subunit gamma DDJ31_RS05635 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DDJ31_RS05640 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DDJ31_RS05645 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DDJ31_RS05660 ENOG4108R6G acetyltransferase DDJ31_RS05680 ENOG4105C83 adenylosuccinate lyase DDJ31_RS05685 ENOG4108VCA G U mismatch-specific DNA glycosylase DDJ31_RS05690 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase DDJ31_RS05755 ENOG4105DKQ ROK family DDJ31_RS05760 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS05765 ENOG4106HB6 Alpha beta hydrolase DDJ31_RS05775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDJ31_RS05835 ENOG4105EYH Exonuclease DDJ31_RS05840 ENOG4107RH8 nuclease SbcCD subunit D DDJ31_RS05845 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DDJ31_RS05860 ENOG4105C8N cysteinyl-tRNA synthetase DDJ31_RS05865 ENOG4105K4P CoA-binding domain protein DDJ31_RS05870 ENOG4107QTZ amino acid DDJ31_RS05890 ENOG4108UW5 maltose o-acetyltransferase DDJ31_RS05895 ENOG4108Z0R Transferase DDJ31_RS05905 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DDJ31_RS05915 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DDJ31_RS05935 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DDJ31_RS05965 ENOG4108WYP Transcriptional regulator DDJ31_RS05980 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DDJ31_RS05995 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DDJ31_RS06010 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DDJ31_RS06015 ENOG4105EP9 oxidoreductase DDJ31_RS06035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DDJ31_RS06040 ENOG4105CHR reductase DDJ31_RS06080 ENOG4105C5Q Transcriptional regulator DDJ31_RS06090 ENOG4105CSW GntR family transcriptional regulator DDJ31_RS06120 ENOG4105NTW Transcriptional regulator DDJ31_RS06125 ENOG4108IG5 Transcriptional regulator DDJ31_RS06135 ENOG4105CPC Aldo Keto reductase DDJ31_RS06150 ENOG4105CDH Citrulline--aspartate ligase DDJ31_RS06160 ENOG4106IPI cyclase, family DDJ31_RS06165 ENOG4105JAB phenazine biosynthesis protein, phzf family DDJ31_RS06190 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS06215 ENOG4105C0X amino acid DDJ31_RS06245 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DDJ31_RS06255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DDJ31_RS06320 ENOG4105C5Y PTS System DDJ31_RS06325 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DDJ31_RS06335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DDJ31_RS06350 ENOG4108UQS dipeptidase DDJ31_RS06375 ENOG4105GWZ Roadblock lc7 family protein DDJ31_RS06390 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase DDJ31_RS06395 ENOG4105VQD rieske 2fe-2S domain-containing protein DDJ31_RS06400 ENOG41069M3 Transcriptional regulator DDJ31_RS06415 ENOG4105F76 Sarcosine oxidase DDJ31_RS06420 ENOG4105DVW rieske (2Fe-2S) DDJ31_RS06425 ENOG4105CUB amino acid DDJ31_RS06450 ENOG4105E7W lamb ycsf family protein DDJ31_RS06455 ENOG4105P4J Allophanate hydrolase, subunit 1 DDJ31_RS06470 ENOG4108MJN Glycosyl Transferase DDJ31_RS06485 ENOG4105JXB ankyrin repeat-containing protein DDJ31_RS06500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDJ31_RS06505 ENOG4108VW9 Membrane DDJ31_RS06515 ENOG4105DEU major facilitator superfamily DDJ31_RS06520 ENOG4105Q70 DDJ31_RS06530 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) DDJ31_RS06540 ENOG4105EW9 transcriptional regulator AsnC family DDJ31_RS06555 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS06605 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DDJ31_RS06610 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase DDJ31_RS06615 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DDJ31_RS06620 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DDJ31_RS06635 ENOG4108KPJ rna polymerase sigma factor DDJ31_RS06640 ENOG4105ECR NmrA family DDJ31_RS06645 ENOG4105E2R ROK family DDJ31_RS06650 ENOG4106UW1 Major Facilitator superfamily DDJ31_RS06655 ENOG4105C2W permease DDJ31_RS06695 ENOG4105CUB amino acid DDJ31_RS06715 ENOG4105DKT Transcriptional regulator DDJ31_RS06720 ENOG4105DJV ribulose-phosphate 3-epimerase DDJ31_RS06730 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DDJ31_RS06765 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DDJ31_RS06775 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DDJ31_RS06780 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DDJ31_RS06790 ENOG4105SKN orotidine 5''-phosphate decarboxylase DDJ31_RS06795 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DDJ31_RS06800 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DDJ31_RS06805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DDJ31_RS06815 ENOG4105CD3 dihydroorotase DDJ31_RS06820 ENOG4105CXT aspartate transcarbamylase DDJ31_RS06825 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DDJ31_RS06835 ENOG410803B Involved in the transcription termination process (By similarity) DDJ31_RS06840 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DDJ31_RS06845 ENOG4105DC7 peptidase M24 DDJ31_RS06855 ENOG4105D49 3-dehydroquinate synthase DDJ31_RS06860 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DDJ31_RS06865 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DDJ31_RS06870 ENOG4105E2X shikimate dehydrogenase DDJ31_RS06875 ENOG4105HHA aminodeoxychorismate lyase DDJ31_RS06880 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DDJ31_RS06885 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DDJ31_RS06905 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DDJ31_RS06920 ENOG4105CUT histidyl-tRNA synthetase DDJ31_RS06930 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) DDJ31_RS06935 ENOG4105C99 atpase involved in dna repair DDJ31_RS06940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DDJ31_RS06945 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DDJ31_RS06950 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DDJ31_RS06955 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DDJ31_RS06965 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DDJ31_RS06970 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DDJ31_RS06975 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DDJ31_RS06980 ENOG4105CDY transcriptional regulatory protein DDJ31_RS06985 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DDJ31_RS06990 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DDJ31_RS07000 ENOG4105E2K Glycosyl transferase (Group 1 DDJ31_RS07005 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase DDJ31_RS07035 ENOG4105C22 threonyL-tRNA synthetase DDJ31_RS07050 ENOG4108JDX DNA polymerase iii, epsilon subunit DDJ31_RS07070 ENOG4105EKC DDJ31_RS07080 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DDJ31_RS07085 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DDJ31_RS07090 ENOG410769Z extracellular solute-binding protein family 1 DDJ31_RS07105 ENOG4105KF0 sporulation and cell division protein, SsgA DDJ31_RS07130 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DDJ31_RS07200 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DDJ31_RS07205 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DDJ31_RS07220 ENOG4105D01 (LipO)protein DDJ31_RS07225 ENOG4108UMI ABC transporter, permease DDJ31_RS07230 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS07235 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 DDJ31_RS07255 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DDJ31_RS07260 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS07265 ENOG4105C57 major facilitator superfamily DDJ31_RS07270 ENOG4105RJZ Transcriptional regulator DDJ31_RS07280 ENOG4105CH7 arginosuccinase DDJ31_RS07310 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DDJ31_RS07315 ENOG4105C8Y Acetylornithine aminotransferase DDJ31_RS07320 ENOG4105CAS nag kinase DDJ31_RS07325 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DDJ31_RS07330 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DDJ31_RS07335 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS07340 ENOG4105EYF MMPL domain protein DDJ31_RS07360 ENOG4105CKK Glycosyl transferase, family 2 DDJ31_RS07390 ENOG4105T38 integral membrane protein DDJ31_RS07400 ENOG4105F32 YngK protein DDJ31_RS07430 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DDJ31_RS07435 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DDJ31_RS07440 ENOG4105BZU Histidine kinase DDJ31_RS07445 ENOG4108RWN rrna methyltransferase DDJ31_RS07450 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DDJ31_RS07455 ENOG41084BS 50S ribosomal protein L35 DDJ31_RS07460 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DDJ31_RS07495 ENOG4105EAC phosphoserine phosphatase DDJ31_RS07500 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DDJ31_RS07505 ENOG4105C26 Dehydrogenase DDJ31_RS07510 ENOG4105C5F glutamine synthetase DDJ31_RS07520 ENOG4108Z86 Glutamine amidotransferase DDJ31_RS07535 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DDJ31_RS07545 ENOG4108HQS Glycine betaine DDJ31_RS07550 ENOG4108IJ7 Glycine betaine DDJ31_RS07555 ENOG4105HFS 5'-3' exonuclease DDJ31_RS07565 ENOG4105D3G Pseudouridine synthase DDJ31_RS07600 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DDJ31_RS07605 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DDJ31_RS07635 ENOG4108V1T peptidylprolyl cis-trans isomerase DDJ31_RS07640 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) DDJ31_RS07650 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS07655 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) DDJ31_RS07660 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) DDJ31_RS07670 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) DDJ31_RS07675 ENOG4105E5F proteasome DDJ31_RS07680 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) DDJ31_RS07710 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS07715 ENOG4105DEF Extracellular solute-binding protein, family 5 DDJ31_RS07720 ENOG4107URF beta-phospho-glucomutase DDJ31_RS07725 ENOG4105C3R Methionine synthase DDJ31_RS07730 ENOG4108K8U Glycerol operon regulatory protein DDJ31_RS07735 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DDJ31_RS07740 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DDJ31_RS07755 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DDJ31_RS07760 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) DDJ31_RS07770 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DDJ31_RS07780 ENOG4108JQ9 ABC transporter DDJ31_RS07785 ENOG4105UIB (ABC) transporter DDJ31_RS07800 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DDJ31_RS07805 ENOG4105JXH GntR family transcriptional regulator DDJ31_RS07815 ENOG4105C8N cysteinyl-tRNA synthetase DDJ31_RS07830 ENOG4108RH7 phosphoglycerate mutase DDJ31_RS07835 ENOG4105D7N magnesium and cobalt transport protein CorA DDJ31_RS07845 ENOG4105DYW oxidoreductase DDJ31_RS07850 ENOG4105CPC Aldo Keto reductase DDJ31_RS07870 ENOG4105S2J secreted protein DDJ31_RS07900 ENOG4105K5B UPF0225 protein DDJ31_RS07905 ENOG4105C6F GntR Family Transcriptional Regulator DDJ31_RS07910 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DDJ31_RS07915 ENOG4105C6Z Gluconate DDJ31_RS07940 ENOG4105PTV Nudix Hydrolase DDJ31_RS07945 ENOG4105VG5 Membrane DDJ31_RS07950 ENOG4105JP4 Inner membrane protein yidG DDJ31_RS07955 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DDJ31_RS07975 ENOG4108IG5 Transcriptional regulator DDJ31_RS07980 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS07985 ENOG4108R85 Short chain dehydrogenase DDJ31_RS07990 ENOG4105EHZ conserved protein UCP016719 DDJ31_RS08010 ENOG4108Z4X TRANSCRIPTIONal DDJ31_RS08030 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS08040 ENOG4108ZHR arsR family transcriptional regulator DDJ31_RS08070 ENOG4105D4T Citrate transporter DDJ31_RS08075 ENOG4108SGK Tetr family transcriptional regulator DDJ31_RS08085 ENOG4105F1J Homogentisate 1,2-dioxygenase DDJ31_RS08105 ENOG4105RNG membrane DDJ31_RS08110 ENOG4105K6V RNA polymerase DDJ31_RS08130 ENOG4108TCJ secreted hydrolase DDJ31_RS08150 ENOG4107BJW polysaccharide deacetylase DDJ31_RS08170 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DDJ31_RS08185 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS08215 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DDJ31_RS08220 ENOG4105C0B DNA polymerase III (alpha subunit) DDJ31_RS08240 ENOG4106NMR serine protease DDJ31_RS08255 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS08265 ENOG4105EAD ABC transporter DDJ31_RS08285 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DDJ31_RS08290 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS08295 ENOG4105C57 major facilitator superfamily DDJ31_RS08305 ENOG410841Q phosphoesterase PA-phosphatase related protein DDJ31_RS08320 ENOG4105MS9 Resuscitation-promoting factor DDJ31_RS08335 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DDJ31_RS08345 ENOG4105CAT Cytidine monophosphate kinase DDJ31_RS08380 ENOG4105FE9 pseudouridine synthase DDJ31_RS08385 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DDJ31_RS08390 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DDJ31_RS08405 ENOG4105DCF alanine dehydrogenase DDJ31_RS08415 ENOG4108YZ4 nudix hydrolase DDJ31_RS08420 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DDJ31_RS08425 ENOG4105BZP glycoside hydrolase 15-related DDJ31_RS08435 ENOG4107QPH glycogen) synthase DDJ31_RS08440 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DDJ31_RS08445 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DDJ31_RS08465 ENOG4105E0A ABC, transporter DDJ31_RS08470 ENOG4105TVJ transport system, permease DDJ31_RS08475 ENOG4105DQ5 transport system permease protein DDJ31_RS08480 ENOG4105DSU hydrolase DDJ31_RS08515 ENOG4108VX5 3-methyladenine DNA glycosylase DDJ31_RS08525 ENOG4108V1U phospholipid-binding protein DDJ31_RS08545 ENOG4105DKW ABC transporter DDJ31_RS08550 ENOG4108UF8 DDJ31_RS08565 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS08570 ENOG4105ENE Histidine kinase DDJ31_RS08575 ENOG4105CHR reductase DDJ31_RS08580 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DDJ31_RS08590 ENOG4105IDI abc transporter atp-binding protein DDJ31_RS08595 ENOG4105EAC phosphoserine phosphatase DDJ31_RS08610 ENOG4105DJ2 Major Facilitator Superfamily DDJ31_RS08615 ENOG41073TP transcriptional regulator DDJ31_RS08625 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DDJ31_RS08630 ENOG4105CHR reductase DDJ31_RS08650 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DDJ31_RS08670 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DDJ31_RS08675 ENOG4107QN1 sodium solute DDJ31_RS08705 ENOG4105E2A Dehydrogenase DDJ31_RS08715 ENOG4107RZZ dna polymerase iii epsilon subunit DDJ31_RS08725 ENOG4105BZP glycoside hydrolase 15-related DDJ31_RS08755 ENOG4105VBF alkaline shock protein DDJ31_RS08775 ENOG4105C5H ABC transporter DDJ31_RS08800 ENOG4107W7X Aldolase DDJ31_RS08820 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DDJ31_RS08825 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DDJ31_RS08830 ENOG4105CTK cobaltochelatase, cobn subunit DDJ31_RS08860 ENOG4105CIA precorrin-4 C(11)-methyltransferase DDJ31_RS08870 ENOG4105E4R Precorrin-3B C17-methyltransferase DDJ31_RS08875 ENOG41081F0 Precorrin-8x methylmutase DDJ31_RS08900 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS08905 ENOG4105EAD ABC transporter DDJ31_RS08910 ENOG4106PMH Extracellular solute-binding protein family 3 DDJ31_RS08915 ENOG4105C5R Aminotransferase DDJ31_RS08920 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase DDJ31_RS08925 ENOG4108JPW Aminotransferase DDJ31_RS08930 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) DDJ31_RS08935 ENOG4105EV8 ectoine hydroxylase DDJ31_RS08965 ENOG4107HP6 Transcriptional regulator DDJ31_RS08980 ENOG4105C7N Xanthine uracil vitamin C permease DDJ31_RS08985 ENOG4105NAF rna polymerase sigma factor DDJ31_RS08995 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DDJ31_RS09010 ENOG4105NBR Pectinesterase DDJ31_RS09015 ENOG4108J20 pectate lyase DDJ31_RS09020 ENOG4107TDE lipolytic protein G-D-S-L family DDJ31_RS09030 ENOG4105E4I Glycoside hydrolase family 28 DDJ31_RS09050 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DDJ31_RS09065 ENOG4105DRR Transcriptional regulator, GntR family DDJ31_RS09075 ENOG4107S5I aldo keto reductase DDJ31_RS09080 ENOG4107RSM transcriptional regulator DDJ31_RS09095 ENOG4105E9Z Nad-dependent epimerase dehydratase DDJ31_RS09100 ENOG4105E98 transcriptional regulator DeoR family DDJ31_RS09120 ENOG4105CPQ Dehydrogenase DDJ31_RS09155 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDJ31_RS09185 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS09195 ENOG4107XBN GntR Family Transcriptional Regulator DDJ31_RS09215 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) DDJ31_RS09220 ENOG4108RFG Tetr family transcriptional regulator DDJ31_RS09225 ENOG410814C multidrug resistance protein DDJ31_RS09235 ENOG4105VG1 fes assembly suf system protein DDJ31_RS09240 ENOG4108UNV SUF system FeS assembly protein, NifU family DDJ31_RS09245 ENOG4105C9B Cysteine desulfurase DDJ31_RS09250 ENOG4105C3K feS assembly ATPase SufC DDJ31_RS09260 ENOG4105JRK feS assembly protein SufD DDJ31_RS09275 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DDJ31_RS09280 ENOG4105CJ1 ABC, transporter DDJ31_RS09290 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DDJ31_RS09300 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DDJ31_RS09310 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DDJ31_RS09325 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) DDJ31_RS09330 ENOG4107QP8 phosphohexose isomerase DDJ31_RS09350 ENOG4105CP7 Triose-phosphate isomerase DDJ31_RS09355 ENOG4105BZA Phosphoglycerate kinase DDJ31_RS09360 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DDJ31_RS09370 ENOG4105CIE May be required for sporulation (By similarity) DDJ31_RS09380 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DDJ31_RS09385 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DDJ31_RS09395 ENOG4105BZU Histidine kinase DDJ31_RS09400 ENOG4105BZU Histidine kinase DDJ31_RS09415 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DDJ31_RS09430 ENOG4107R0W ABC transporter DDJ31_RS09435 ENOG4105E5Q amino acid AbC transporter DDJ31_RS09445 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DDJ31_RS09450 ENOG4105CSH Transporter DDJ31_RS09475 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DDJ31_RS09480 ENOG4105BZU Histidine kinase DDJ31_RS09485 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DDJ31_RS09490 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DDJ31_RS09495 ENOG4105E2A Dehydrogenase DDJ31_RS09505 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) DDJ31_RS09510 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DDJ31_RS09515 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS09520 ENOG4105D7N magnesium and cobalt transport protein CorA DDJ31_RS09605 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) DDJ31_RS09620 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DDJ31_RS09625 ENOG4105DRR Transcriptional regulator, GntR family DDJ31_RS09655 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DDJ31_RS09675 ENOG4105CQ7 ATP-dependent helicase DDJ31_RS09715 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) DDJ31_RS09725 ENOG4105C32 Amino acid ABC transporter (Permease) DDJ31_RS09730 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DDJ31_RS09735 ENOG4105C0Z ABC transporter DDJ31_RS09740 ENOG4108IV0 ABC, transporter DDJ31_RS09770 ENOG4105CGH 5'-nucleotidase DDJ31_RS09790 ENOG4105C5Q Transcriptional regulator DDJ31_RS09795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DDJ31_RS09835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS09840 ENOG4105EHE chorismate mutase- prephenate dehydrogenase DDJ31_RS09860 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr DDJ31_RS09870 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS09885 ENOG4105EA8 2-Nitropropane dioxygenase DDJ31_RS09895 ENOG4105F2C Acetyl-CoA acetyltransferase DDJ31_RS09900 ENOG4108RZE Tetr family transcriptional regulator DDJ31_RS09905 ENOG4105CHR reductase DDJ31_RS09910 ENOG4105D2B acyl-CoA dehydrogenase DDJ31_RS09920 ENOG4105MUA Resistance protein DDJ31_RS09935 ENOG4105CBC glutamate synthase DDJ31_RS09945 ENOG41065RQ ADP-ribosylation crystallin J1 DDJ31_RS09965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DDJ31_RS09975 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DDJ31_RS09985 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DDJ31_RS09990 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DDJ31_RS10000 ENOG4105DK0 Indole-3-glycerol phosphate synthase DDJ31_RS10015 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS10025 ENOG4105CMT Dihydroxyacetone kinase DDJ31_RS10040 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DDJ31_RS10050 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DDJ31_RS10055 ENOG4108176 endoribonuclease L-psp DDJ31_RS10060 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DDJ31_RS10065 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DDJ31_RS10075 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DDJ31_RS10080 ENOG4105CIH Imidazole acetol-phosphate transaminase DDJ31_RS10085 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DDJ31_RS10105 ENOG4108Z66 YbaK ebsC protein DDJ31_RS10135 ENOG4105C0B DNA polymerase III (alpha subunit) DDJ31_RS10185 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DDJ31_RS10195 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DDJ31_RS10200 ENOG4107VQS DivIVA family DDJ31_RS10210 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DDJ31_RS10215 ENOG4105DFA alanine racemase domain protein DDJ31_RS10220 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DDJ31_RS10225 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DDJ31_RS10230 ENOG4105ME9 cell division protein FtsQ DDJ31_RS10235 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DDJ31_RS10245 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DDJ31_RS10250 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DDJ31_RS10260 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DDJ31_RS10265 ENOG4105CJN penicillin-binding protein DDJ31_RS10275 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DDJ31_RS10285 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DDJ31_RS10305 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DDJ31_RS10315 ENOG4107Z3H Transcriptional regulator, TetR family DDJ31_RS10325 ENOG4105EWK phytoene DDJ31_RS10340 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DDJ31_RS10365 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DDJ31_RS10375 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DDJ31_RS10380 ENOG4108UQY Iron-storage protein DDJ31_RS10390 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase DDJ31_RS10405 ENOG4105CTQ phosphohexokinase DDJ31_RS10415 ENOG4108XG2 Histidine kinase DDJ31_RS10440 ENOG4105DKQ ROK family DDJ31_RS10450 ENOG4105D0U Arsenite-activated ATPase (ArsA) DDJ31_RS10490 ENOG4105K4H Nlp p60 protein DDJ31_RS10520 ENOG4105C9B Cysteine desulfurase DDJ31_RS10525 ENOG4108I0Q anthranilate phosphoribosyltransferase DDJ31_RS10530 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DDJ31_RS10535 ENOG4107EUI c reductase, iron-sulfur DDJ31_RS10540 ENOG4107UDY cytochrome C DDJ31_RS10545 ENOG4105CCU oxidase (Subunit III) DDJ31_RS10555 ENOG4107UBC ErfK ybiS ycfS ynhG family protein DDJ31_RS10560 ENOG4105MCD Part of cytochrome c oxidase, its function is DDJ31_RS10565 ENOG4105BZ9 Cytochrome C oxidase, subunit I DDJ31_RS10570 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) DDJ31_RS10580 ENOG4107T4Z adenosine kinase DDJ31_RS10600 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DDJ31_RS10610 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS10615 ENOG4105BZU Histidine kinase DDJ31_RS10640 ENOG4105C0H protease DDJ31_RS10650 ENOG4108YZT Adenosylcobinamide kinase DDJ31_RS10660 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DDJ31_RS10665 ENOG4105CRK lysyL-tRNA synthetase DDJ31_RS10680 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DDJ31_RS10690 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DDJ31_RS10710 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DDJ31_RS10760 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DDJ31_RS10765 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DDJ31_RS10795 ENOG4105D0M Protease HtpX homolog DDJ31_RS10820 ENOG4106SPC secreted protein DDJ31_RS10825 ENOG4107R5B glutamine synthetase DDJ31_RS10830 ENOG4107NHD transcriptional regulator DDJ31_RS10875 ENOG41060BG Tetr family transcriptional regulator DDJ31_RS10910 ENOG4105CG3 alpha amylase, catalytic region DDJ31_RS10915 ENOG4105EG2 ABC transporter, permease DDJ31_RS10920 ENOG4105D56 permease protein DDJ31_RS10930 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS10940 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DDJ31_RS10945 ENOG4105FBN Acid phosphatase DDJ31_RS10960 ENOG4105C5F glutamine synthetase DDJ31_RS10980 ENOG4105C4K Nad synthetase DDJ31_RS10995 ENOG4105F27 Major Facilitator DDJ31_RS11010 ENOG4105C57 major facilitator superfamily DDJ31_RS11015 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DDJ31_RS11035 ENOG4107XZ0 Peptidase M50 DDJ31_RS11095 ENOG4105EHG Permease protein DDJ31_RS11100 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS11105 ENOG410650H (LipO)protein DDJ31_RS11110 ENOG4105DBE peroxidase DDJ31_RS11120 ENOG4106A0S DDJ31_RS11130 ENOG4105YIP Tetr family transcriptional regulator DDJ31_RS11145 ENOG4105C2C drug resistance transporter, Bcr CflA DDJ31_RS11170 ENOG4105C19 ABC transporter DDJ31_RS11180 ENOG4108VGI doxx family DDJ31_RS11270 ENOG4107XFJ UPF0246 protein DDJ31_RS11275 ENOG4108UHU Aldolase DDJ31_RS11290 ENOG4105EGD dinuclear metal center protein, YbgI family DDJ31_RS11305 ENOG4105CHR reductase DDJ31_RS11330 ENOG4108S01 response regulator DDJ31_RS11355 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DDJ31_RS11415 ENOG4105DYW oxidoreductase DDJ31_RS11435 ENOG4107QVI Methyltransferase, type 11 DDJ31_RS11440 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS11445 ENOG4108SGK Tetr family transcriptional regulator DDJ31_RS11480 ENOG4105BZ1 (ABC) transporter DDJ31_RS11495 ENOG4105XPP Protein of unknown function (DUF1275) DDJ31_RS11500 ENOG4106A3M Cytochrome p-450 DDJ31_RS11505 ENOG4105F2C Acetyl-CoA acetyltransferase DDJ31_RS11520 ENOG4105CSH Transporter DDJ31_RS11565 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 DDJ31_RS11585 ENOG4105MGM doxx family DDJ31_RS11650 ENOG4105DAX Pfam:DUF2983 DDJ31_RS11695 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DDJ31_RS11700 ENOG4105EYW Ion transport protein DDJ31_RS11730 ENOG4105VUF Transcriptional regulator DDJ31_RS11765 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DDJ31_RS11785 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DDJ31_RS11790 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DDJ31_RS11800 ENOG4105NGS secreted protein DDJ31_RS11805 ENOG4105EXN Sulfate transport protein CysZ DDJ31_RS11815 ENOG4108ZHJ Organic hydroperoxide resistance protein DDJ31_RS11820 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DDJ31_RS11835 ENOG4105CXK mandelate racemase muconate lactonizing DDJ31_RS11850 ENOG4105DFW ABC transporter DDJ31_RS11860 ENOG4108HWW ABC transporter DDJ31_RS11865 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DDJ31_RS11870 ENOG4105CIH Imidazole acetol-phosphate transaminase DDJ31_RS11880 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase DDJ31_RS11890 ENOG410635A Membrane DDJ31_RS11950 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DDJ31_RS11955 ENOG41069M3 Transcriptional regulator DDJ31_RS11975 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS11985 ENOG4105DFF Rod shape-determining protein mreb DDJ31_RS12045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS12050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DDJ31_RS12060 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein DDJ31_RS12075 ENOG4108UB4 uncharacterized protein ygjQ DDJ31_RS12090 ENOG4108YYH Nadph-dependent fmn reductase DDJ31_RS12135 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DDJ31_RS12140 ENOG4105E2R ROK family DDJ31_RS12220 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DDJ31_RS12240 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DDJ31_RS12250 ENOG4105E39 Enoyl-CoA hydratase DDJ31_RS12280 ENOG4105CPC Aldo Keto reductase DDJ31_RS12290 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DDJ31_RS12295 ENOG4105DSE periplasmic solute binding protein DDJ31_RS12300 ENOG4105FDK ABC transporter DDJ31_RS12305 ENOG4105FAV ABC, transporter DDJ31_RS12320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DDJ31_RS12325 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DDJ31_RS12340 ENOG4105DEF Extracellular solute-binding protein, family 5 DDJ31_RS12355 ENOG4108JQ7 (ABC) transporter DDJ31_RS12360 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DDJ31_RS12365 ENOG4105W5A BNR Asp-box repeat protein DDJ31_RS12375 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DDJ31_RS12380 ENOG4105D4Y metalloprotease DDJ31_RS12395 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DDJ31_RS12425 ENOG4105MSB protein, conserved in bacteria DDJ31_RS12435 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DDJ31_RS12455 ENOG4105EQX glucarate dehydratase DDJ31_RS12460 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase DDJ31_RS12480 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DDJ31_RS12485 ENOG4107YU2 histidine triad (hIT) protein DDJ31_RS12490 ENOG4107RE3 peptidase, S41 DDJ31_RS12505 ENOG4107QWG 2-Nitropropane dioxygenase DDJ31_RS12510 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DDJ31_RS12515 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DDJ31_RS12520 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DDJ31_RS12545 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DDJ31_RS12555 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DDJ31_RS12560 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DDJ31_RS12580 ENOG4108YYC ycei family DDJ31_RS12590 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein DDJ31_RS12595 ENOG4105EPR degv family DDJ31_RS12605 ENOG4105C8T Leucyl-tRNA synthetase DDJ31_RS12615 ENOG4107QIZ NADH dehydrogenase DDJ31_RS12645 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DDJ31_RS12650 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) DDJ31_RS12660 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DDJ31_RS12675 ENOG4105D0M Protease HtpX homolog DDJ31_RS12690 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DDJ31_RS12700 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DDJ31_RS12710 ENOG4105K64 Glycosyl transferase, family 2 DDJ31_RS12730 ENOG4105DGI Alkaline phosphatase DDJ31_RS12735 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DDJ31_RS12740 ENOG4105K46 50S ribosomal protein l27 DDJ31_RS12745 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DDJ31_RS12750 ENOG4105C03 ribonuclease DDJ31_RS12775 ENOG4105CNI cell division protein FtsW DDJ31_RS12780 ENOG4105CJN penicillin-binding protein DDJ31_RS12795 ENOG4105DFF Rod shape-determining protein mreb DDJ31_RS12800 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DDJ31_RS12810 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DDJ31_RS12815 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DDJ31_RS12825 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DDJ31_RS12830 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DDJ31_RS12835 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DDJ31_RS12840 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DDJ31_RS12860 ENOG4108TGC Acyltransferase DDJ31_RS12870 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DDJ31_RS12895 ENOG4105C85 amino acid DDJ31_RS12905 ENOG4105C85 amino acid DDJ31_RS12910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DDJ31_RS12915 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DDJ31_RS12920 ENOG4105CMG Carbohydrate kinase DDJ31_RS12925 ENOG4107VUR extracellular solute-binding protein DDJ31_RS12970 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DDJ31_RS12975 ENOG4105MC2 DSBA oxidoreductase DDJ31_RS13025 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDJ31_RS13060 ENOG4108KTG Membrane protein, drug metabolite transporter DDJ31_RS13065 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DDJ31_RS13070 ENOG4107SCK Monooxygenase DDJ31_RS13100 ENOG4105D8X mechanosensitive ion channel DDJ31_RS13115 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component DDJ31_RS13120 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DDJ31_RS13125 ENOG4105F8D glycoside hydrolase family 4 DDJ31_RS13145 ENOG4105CT1 (ABC) transporter DDJ31_RS13175 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DDJ31_RS13305 ENOG4105PWE CRISPR-associated protein cas2 DDJ31_RS13310 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) DDJ31_RS13405 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS13435 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DDJ31_RS13445 ENOG4107RZZ dna polymerase iii epsilon subunit DDJ31_RS13490 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DDJ31_RS13590 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DDJ31_RS13750 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DDJ31_RS13830 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DDJ31_RS13915 ENOG4105CPK Glycosyl transferase (Group 1 DDJ31_RS13930 ENOG4105CJR Integral membrane protein (MviN DDJ31_RS13940 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS13970 ENOG4105S2J secreted protein DDJ31_RS14000 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DDJ31_RS14010 ENOG4105CJ1 ABC, transporter DDJ31_RS14015 ENOG4105C26 Dehydrogenase DDJ31_RS14020 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DDJ31_RS14025 ENOG4105DH8 myo-inositol catabolism DDJ31_RS14035 ENOG4105EDK PfkB domain protein DDJ31_RS14040 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DDJ31_RS14050 ENOG4105CPQ Dehydrogenase DDJ31_RS14085 ENOG4105C7H Helicase, RecD TraA family DDJ31_RS14125 ENOG4105C2J ABC transporter DDJ31_RS14130 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DDJ31_RS14135 ENOG4108RVA ribokinase DDJ31_RS14140 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DDJ31_RS14160 ENOG4107YM4 Beta-lactamase domain-containing protein DDJ31_RS14200 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS14210 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS14215 ENOG4105BZU Histidine kinase DDJ31_RS14230 ENOG410645S MarR family Transcriptional regulator DDJ31_RS14240 ENOG4108594 Permease of the drug metabolite transporter DDJ31_RS14250 ENOG4105D17 glycoside hydrolase, family 3 domain protein DDJ31_RS14285 ENOG4105EDW glycosyl transferase, family 39 DDJ31_RS14290 ENOG4108K8S endonuclease I DDJ31_RS14310 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A DDJ31_RS14315 ENOG4105C7K acetolactate synthase DDJ31_RS14325 ENOG4105CK7 Sodium proline symporter DDJ31_RS14335 ENOG4108XFF DDJ31_RS14340 ENOG4105C29 acyl-CoA thioesterase DDJ31_RS14355 ENOG4107QX3 carboxylase DDJ31_RS14365 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DDJ31_RS14370 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS14375 ENOG4105ESF Peptidoglycan binding domain protein DDJ31_RS14405 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) DDJ31_RS14415 ENOG4105DUU IucA IucC family protein DDJ31_RS14420 ENOG4105E2D ec 3.2.1.52 DDJ31_RS14440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DDJ31_RS14455 ENOG4105ECQ AraC Family Transcriptional Regulator DDJ31_RS14460 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DDJ31_RS14480 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS14505 ENOG4108NNZ chitinase DDJ31_RS14510 ENOG4105BZU Histidine kinase DDJ31_RS14565 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DDJ31_RS14590 ENOG4105BZU Histidine kinase DDJ31_RS14595 ENOG4105DEN Luciferase family DDJ31_RS14610 ENOG4105C5I Dehydrogenase DDJ31_RS14615 ENOG4105DV0 amidase (EC 3.5.1.4 DDJ31_RS14655 ENOG4105J5T Amp-dependent synthetase and ligase DDJ31_RS14660 ENOG4108M1A Chitin-binding protein DDJ31_RS14680 ENOG4105JXH GntR family transcriptional regulator DDJ31_RS14695 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) DDJ31_RS14720 ENOG4105CY5 solute-binding protein DDJ31_RS14725 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DDJ31_RS14730 ENOG4108MP3 ABC transporter, permease DDJ31_RS14735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS14740 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DDJ31_RS14745 ENOG4105MWK D-amino acid dehydrogenase, small subunit DDJ31_RS14750 ENOG41080U6 GntR family transcriptional regulator DDJ31_RS14760 ENOG4105E2R ROK family DDJ31_RS14765 ENOG4105D9R oxidoreductase DDJ31_RS14770 ENOG41090KN UPF0303 protein DDJ31_RS14835 ENOG4108U4N (sortase) family DDJ31_RS14850 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DDJ31_RS14890 ENOG4107QNK )-transporter DDJ31_RS14895 ENOG4106BRA Membrane DDJ31_RS14925 ENOG4105BZ4 penicillin-binding protein DDJ31_RS14955 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DDJ31_RS14965 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DDJ31_RS14985 ENOG4108RQ5 Beta-lactamase domain-containing protein DDJ31_RS15010 ENOG4105C85 amino acid DDJ31_RS15020 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DDJ31_RS15030 ENOG4108RWI nicotinamidase DDJ31_RS15080 ENOG4105KF0 sporulation and cell division protein, SsgA DDJ31_RS15085 ENOG4105CQB FAD linked oxidase domain protein DDJ31_RS15100 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DDJ31_RS15110 ENOG4105E90 ABC transporter DDJ31_RS15115 ENOG4108IJ8 ABC transporter DDJ31_RS15120 ENOG4105E90 ABC transporter DDJ31_RS15130 ENOG41063PX domain protein DDJ31_RS15215 ENOG4105E2D ec 3.2.1.52 DDJ31_RS15240 ENOG4108UJU UPF0301 protein DDJ31_RS15245 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DDJ31_RS15250 ENOG4108426 dNA-binding protein DDJ31_RS15260 ENOG4105EEM helicase DDJ31_RS15300 ENOG4106NZI LysR family Transcriptional regulator DDJ31_RS15325 ENOG4105CJQ hydrolase, family 31 DDJ31_RS15340 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DDJ31_RS15345 ENOG4105CN1 protease DDJ31_RS15355 ENOG4105CAK Cell division ATP-binding protein ftsE DDJ31_RS15370 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DDJ31_RS15375 ENOG4108QVN serine threonine protein kinase DDJ31_RS15380 ENOG4108UGD Serine Threonine protein kinase DDJ31_RS15390 ENOG4105EPJ extracellular solute-binding protein family 1 DDJ31_RS15395 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component DDJ31_RS15400 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component DDJ31_RS15405 ENOG4107SJB teichoic acid biosynthesis DDJ31_RS15410 ENOG4107SJB teichoic acid biosynthesis DDJ31_RS15415 ENOG4105K64 Glycosyl transferase, family 2 DDJ31_RS15435 ENOG4108ZHJ Organic hydroperoxide resistance protein DDJ31_RS15440 ENOG4105K56 Transcriptional regulator DDJ31_RS15475 ENOG4105EY8 ABC transporter DDJ31_RS15485 ENOG4105CSH Transporter DDJ31_RS15495 ENOG4105C7I Dehydrogenase DDJ31_RS15520 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DDJ31_RS15530 ENOG4105T0Z Conserved Protein DDJ31_RS15535 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS15540 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea DDJ31_RS15550 ENOG4105G3P Lipoprotein lpqB DDJ31_RS15555 ENOG4105BZU Histidine kinase DDJ31_RS15560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS15565 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DDJ31_RS15580 ENOG4108WQ6 secreted protein DDJ31_RS15585 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DDJ31_RS15625 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) DDJ31_RS15635 ENOG4105EIP mannose-6-phosphate isomerase DDJ31_RS15645 ENOG4105W49 UPF0434 protein DDJ31_RS15650 ENOG4107QKV phosphomannomutase DDJ31_RS15655 ENOG4105DAA L-lactate DDJ31_RS15675 ENOG4107RGC Glycosyl transferase, family 2 DDJ31_RS15680 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DDJ31_RS15695 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) DDJ31_RS15705 ENOG4107V9E glucose-1-phosphate thymidylyltransferase DDJ31_RS15720 ENOG4108RCF TRANSCRIPTIONal DDJ31_RS15730 ENOG4107TB5 TRANSCRIPTIONal DDJ31_RS15750 ENOG4108KGH TRANSCRIPTIONal DDJ31_RS15765 ENOG4105C6Y Udp-glucose 6-dehydrogenase DDJ31_RS15790 ENOG4108Z6Z Transcriptional regulator DDJ31_RS15800 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DDJ31_RS15815 ENOG41065SU Two-component system sensor kinase DDJ31_RS15820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS15825 ENOG4105DUX Transporter DDJ31_RS15830 ENOG410829K Lysine exporter protein (Lyse ygga) DDJ31_RS15860 ENOG41082AN stage II sporulation protein DDJ31_RS15865 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS15870 ENOG4105CI2 imidazolone-5-propionate hydrolase DDJ31_RS15885 ENOG4105CGP Urocanate hydratase DDJ31_RS15925 ENOG4105C84 Histidine ammonia-lyase DDJ31_RS15930 ENOG4108V9Q carbonic anhydrase DDJ31_RS15935 ENOG4105CHH sulfate transporter DDJ31_RS15955 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS15990 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDJ31_RS15995 ENOG4107RBB ABC transporter, permease DDJ31_RS16000 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DDJ31_RS16005 ENOG4105CEP NADH dehydrogenase DDJ31_RS16025 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DDJ31_RS16040 ENOG4106A3M Cytochrome p-450 DDJ31_RS16060 ENOG4105D9P serine threonine protein kinase DDJ31_RS16085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDJ31_RS16090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDJ31_RS16095 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDJ31_RS16125 ENOG4105BZU Histidine kinase DDJ31_RS16140 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DDJ31_RS16145 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DDJ31_RS16150 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DDJ31_RS16155 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DDJ31_RS16165 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) DDJ31_RS16175 ENOG41067SE Tetr family transcriptional regulator DDJ31_RS16185 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) DDJ31_RS16190 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DDJ31_RS16195 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS16245 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DDJ31_RS16285 ENOG4105C5H ABC transporter DDJ31_RS16290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DDJ31_RS16295 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DDJ31_RS16305 ENOG4105F8V Hydrolase, tatD family DDJ31_RS16335 ENOG4105KF0 sporulation and cell division protein, SsgA DDJ31_RS16340 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) DDJ31_RS16350 ENOG4108JJB ABC transporter DDJ31_RS16355 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DDJ31_RS16370 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DDJ31_RS16375 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DDJ31_RS16380 ENOG4105EYF MMPL domain protein DDJ31_RS16400 ENOG4108R85 Short chain dehydrogenase DDJ31_RS16405 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DDJ31_RS16410 ENOG4105F95 Monooxygenase DDJ31_RS16445 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DDJ31_RS16450 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DDJ31_RS16460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DDJ31_RS16465 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase DDJ31_RS16475 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) DDJ31_RS16490 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) DDJ31_RS16500 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DDJ31_RS16520 ENOG4105KXX peptidase s58 dmpa DDJ31_RS16535 ENOG4105DM4 PTS System DDJ31_RS16545 ENOG410804X Transcriptional regulator DDJ31_RS16570 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DDJ31_RS16610 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DDJ31_RS16650 ENOG4107RIQ Sulfate adenylate transferase DDJ31_RS16685 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DDJ31_RS16700 ENOG4108V06 Glutathione peroxidase DDJ31_RS16795 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) DDJ31_RS16845 ENOG4105F0K SARP family transcriptional regulator DDJ31_RS16855 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS16885 ENOG4105CPC Aldo Keto reductase DDJ31_RS16895 ENOG4108762 serine threonine protein kinase DDJ31_RS16905 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) DDJ31_RS16935 ENOG4105D2B acyl-CoA dehydrogenase DDJ31_RS16955 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) DDJ31_RS16975 ENOG4105H3G oxidoreductase DDJ31_RS16980 ENOG4105CMV Succinyl-CoA synthetase subunit beta DDJ31_RS16985 ENOG4105CGU Enoyl-CoA hydratase DDJ31_RS16995 ENOG4107QRA Extracellular solute-binding protein, family 5 DDJ31_RS17005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS17010 ENOG4108JQ6 ABC transporter DDJ31_RS17025 ENOG4105D2S major facilitator superfamily DDJ31_RS17030 ENOG4105ECQ AraC Family Transcriptional Regulator DDJ31_RS17040 ENOG4105CC9 acyl-Coa dehydrogenase DDJ31_RS17045 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr DDJ31_RS17060 ENOG4105D2B acyl-CoA dehydrogenase DDJ31_RS17065 ENOG4105CC9 acyl-Coa dehydrogenase DDJ31_RS17075 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS17085 ENOG41082AN stage II sporulation protein DDJ31_RS17140 ENOG4108XEP Alpha Beta Hydrolase Fold protein DDJ31_RS17150 ENOG4108SU4 UPF0309 protein DDJ31_RS17170 ENOG4105BZU Histidine kinase DDJ31_RS17175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS17225 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) DDJ31_RS17240 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS17255 ENOG4107QX3 carboxylase DDJ31_RS17270 ENOG4105CHR reductase DDJ31_RS17285 ENOG4107AQZ Membrane DDJ31_RS17300 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DDJ31_RS17305 ENOG4105CQB FAD linked oxidase domain protein DDJ31_RS17310 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DDJ31_RS17315 ENOG4105JAB phenazine biosynthesis protein, phzf family DDJ31_RS17360 ENOG4107SCK Monooxygenase DDJ31_RS17370 ENOG4106R7G Glycoside hydrolase family 5 DDJ31_RS17390 ENOG4105CPC Aldo Keto reductase DDJ31_RS17410 ENOG4105C7N Xanthine uracil vitamin C permease DDJ31_RS17420 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DDJ31_RS17440 ENOG4108N0W Major Facilitator superfamily DDJ31_RS17450 ENOG4108UIH futalosine nucleosidase DDJ31_RS17455 ENOG4105E63 Pfam:DUF178 DDJ31_RS17460 ENOG4105VEQ Cold shock protein DDJ31_RS17485 ENOG4105EEM helicase DDJ31_RS17495 ENOG4105CFI type iii restriction protein res subunit DDJ31_RS17500 ENOG4106N3A copper homeostasis protein cutc DDJ31_RS17510 ENOG4105KNA -acetyltransferase DDJ31_RS17525 ENOG4105QEK Transcriptional regulator DDJ31_RS17530 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DDJ31_RS17535 ENOG4105C5Y PTS System DDJ31_RS17550 ENOG4105EBR Carboxylesterase DDJ31_RS17560 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDJ31_RS17565 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DDJ31_RS17570 ENOG4105VEQ Cold shock protein DDJ31_RS17585 ENOG4105C3Q Glycosyl transferase, family 2 DDJ31_RS17590 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DDJ31_RS17615 ENOG4105CE4 GlcNAc 6-P deacetylase DDJ31_RS17620 ENOG4105DE4 1-phosphofructokinase DDJ31_RS17630 ENOG4105BZU Histidine kinase DDJ31_RS17700 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DDJ31_RS17795 ENOG4108YS0 lipoprotein YafL DDJ31_RS17905 ENOG4105C2N RNA methyltransferase TrmH family group 3 DDJ31_RS17910 ENOG4105C8N cysteinyl-tRNA synthetase DDJ31_RS17915 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DDJ31_RS17920 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DDJ31_RS17925 ENOG4108VJ1 Transcriptional regulator (CarD family DDJ31_RS17940 ENOG4105BZU Histidine kinase DDJ31_RS17955 ENOG4108HMN Caspase domain DDJ31_RS17980 ENOG4105CZE histidine utilization repressor DDJ31_RS17990 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DDJ31_RS18045 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS18145 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DDJ31_RS18160 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DDJ31_RS18190 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DDJ31_RS18200 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS18205 ENOG4105HHS UPF0256 protein DDJ31_RS18220 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DDJ31_RS18225 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DDJ31_RS18230 ENOG41090R7 Ferric uptake DDJ31_RS18235 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands DDJ31_RS18285 ENOG4105PKJ carbohydrate binding DDJ31_RS18290 ENOG4105KHC sulfurtransferase DDJ31_RS18315 ENOG4107NHD transcriptional regulator DDJ31_RS18320 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS18325 ENOG4105C0H protease DDJ31_RS18330 ENOG4105ETX regulatoR DDJ31_RS18340 ENOG4105BZ1 (ABC) transporter DDJ31_RS18345 ENOG4105CGH 5'-nucleotidase DDJ31_RS18350 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DDJ31_RS18365 ENOG4105CIG ABC transporter DDJ31_RS18380 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DDJ31_RS18385 ENOG4105CZV ABC transporter DDJ31_RS18400 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DDJ31_RS18430 ENOG4105VPX protein, conserved in bacteria DDJ31_RS18440 ENOG4105CJ3 phosphate transporter DDJ31_RS18445 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS18465 ENOG4105DNP FAD linked oxidase domain protein DDJ31_RS18470 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DDJ31_RS18475 ENOG4105E4C Lytic transglycosylase catalytic DDJ31_RS18570 ENOG4105ESP cell wall surface anchor family protein DDJ31_RS18585 ENOG4105D5U fad dependent oxidoreductase DDJ31_RS18590 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DDJ31_RS18600 ENOG4105CPC Aldo Keto reductase DDJ31_RS18635 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DDJ31_RS18650 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DDJ31_RS18680 ENOG4105C1J atp-dependent rna helicase DDJ31_RS18720 ENOG4105CQ7 ATP-dependent helicase DDJ31_RS18740 ENOG4108TAC DDJ31_RS18755 ENOG4105CXB phosphoribosylaminoimidazole synthetase DDJ31_RS18775 ENOG410630P Transcriptional regulator DDJ31_RS18785 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DDJ31_RS18790 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DDJ31_RS18795 ENOG410839H phosphoribosylformylglycinamidine synthase DDJ31_RS18830 ENOG4108S01 response regulator DDJ31_RS18840 ENOG4105C8V SAICAR synthetase DDJ31_RS18855 ENOG4105C12 Phosphoribosylglycinamide synthetase DDJ31_RS18925 ENOG4105D7A ATP-binding protein DDJ31_RS18940 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DDJ31_RS18955 ENOG4108Z6B deaminase DDJ31_RS18970 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein DDJ31_RS18975 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS18980 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS18995 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DDJ31_RS19000 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDJ31_RS19005 ENOG4108YYC ycei family DDJ31_RS19010 ENOG410905P Pyridoxamine 5-phosphate DDJ31_RS19020 ENOG4105C57 major facilitator superfamily DDJ31_RS19025 ENOG4105EDW glycosyl transferase, family 39 DDJ31_RS19035 ENOG4105BZU Histidine kinase DDJ31_RS19040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS19070 ENOG4105DJB Major Facilitator Superfamily DDJ31_RS19090 ENOG4108UXN response regulator DDJ31_RS19105 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS19110 ENOG4105NAF rna polymerase sigma factor DDJ31_RS19150 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS19180 ENOG4105C0H protease DDJ31_RS19195 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DDJ31_RS19215 ENOG4107T6F Xaa-Pro aminopeptidase DDJ31_RS19220 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase DDJ31_RS19255 ENOG4105DBE peroxidase DDJ31_RS19265 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DDJ31_RS19270 ENOG410667J hydrolase DDJ31_RS19310 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) DDJ31_RS19320 ENOG410667J hydrolase DDJ31_RS19325 ENOG4105E4C Lytic transglycosylase catalytic DDJ31_RS19335 ENOG4108JJ9 ABC, transporter DDJ31_RS19340 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DDJ31_RS19345 ENOG4105C4M (Ubiquinol oxidase) subunit I DDJ31_RS19350 ENOG4105CIH Imidazole acetol-phosphate transaminase DDJ31_RS19355 ENOG4107P2S Transcriptional regulator DDJ31_RS19380 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DDJ31_RS19405 ENOG4106048 Cupin 2, conserved barrel domain protein DDJ31_RS19410 ENOG41082T9 Membrane DDJ31_RS19415 ENOG4105KJF protein tyrosine phosphatase DDJ31_RS19420 ENOG4105C28 cystathionine DDJ31_RS19435 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DDJ31_RS19485 ENOG4105CDU Replicative dna helicase DDJ31_RS19495 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DDJ31_RS19500 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DDJ31_RS19505 ENOG4107YH6 single-stranded DNA-binding protein DDJ31_RS19510 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) DDJ31_RS19545 ENOG4105BZ4 penicillin-binding protein DDJ31_RS19570 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DDJ31_RS19585 ENOG4105D9P serine threonine protein kinase DDJ31_RS19600 ENOG4105C3M thioredoxin reductase DDJ31_RS19605 ENOG4105K63 Thioredoxin DDJ31_RS19620 ENOG4107QJE Chromosome Partitioning Protein DDJ31_RS19625 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DDJ31_RS19635 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DDJ31_RS19640 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DDJ31_RS19645 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DDJ31_RS19650 ENOG41084CH 50S ribosomal protein l34 DDJ31_RS19655 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DDJ31_RS19660 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DDJ31_RS19665 ENOG4108J5G 6-phosphogluconate dehydrogenase DDJ31_RS19670 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DDJ31_RS19675 ENOG4105K7N UPF0232 protein DDJ31_RS19680 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DDJ31_RS19685 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DDJ31_RS19745 ENOG4105GFG DUF218 domain DDJ31_RS19770 ENOG4108UGD Serine Threonine protein kinase DDJ31_RS19785 ENOG4105C6T cysteine synthase DDJ31_RS19805 ENOG4105ZJT Cell division protein CrgA DDJ31_RS19815 ENOG4108U4N (sortase) family DDJ31_RS19830 ENOG4108U4N (sortase) family DDJ31_RS19835 ENOG4108RN7 integral membrane protein DDJ31_RS19845 ENOG4105CJN penicillin-binding protein DDJ31_RS19860 ENOG4105HZM Fha domain containing protein DDJ31_RS19865 ENOG4105TV9 FHA Domain-Containing protein DDJ31_RS19875 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DDJ31_RS19880 ENOG4105KVH Transcriptional regulator DDJ31_RS19905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DDJ31_RS19910 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit DDJ31_RS19915 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit DDJ31_RS19920 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit DDJ31_RS19925 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit DDJ31_RS19940 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase DDJ31_RS19950 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS19955 ENOG4108IG5 Transcriptional regulator DDJ31_RS19995 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DDJ31_RS20010 ENOG4107QPV Serine Threonine protein kinase DDJ31_RS20040 ENOG4105CPP Dehydrogenase, E1 component DDJ31_RS20045 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 DDJ31_RS20085 ENOG4105DFM M18 family aminopeptidase DDJ31_RS20090 ENOG4105CSU acyl-Coa dehydrogenase DDJ31_RS20100 ENOG4105EUB pirin domain protein DDJ31_RS20115 ENOG4105C9M aspartyl-trna synthetase DDJ31_RS20135 ENOG4108J20 pectate lyase DDJ31_RS20180 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DDJ31_RS20195 ENOG4108KXM LysR family Transcriptional regulator DDJ31_RS20205 ENOG4105EM2 membrane DDJ31_RS20245 ENOG4105CB2 alcohol dehydrogenase DDJ31_RS20250 ENOG4108Z4X TRANSCRIPTIONal DDJ31_RS20265 ENOG4105DU0 nucleoside hydrolase DDJ31_RS20270 ENOG4105CPC Aldo Keto reductase DDJ31_RS20280 ENOG4105CG3 alpha amylase, catalytic region DDJ31_RS20340 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DDJ31_RS20345 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DDJ31_RS20350 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) DDJ31_RS20370 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DDJ31_RS20375 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DDJ31_RS20390 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DDJ31_RS20395 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DDJ31_RS20405 ENOG4105CR4 methylisocitrate lyase DDJ31_RS20415 ENOG4105BZU Histidine kinase DDJ31_RS20440 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DDJ31_RS20455 ENOG4105C1J atp-dependent rna helicase DDJ31_RS20460 ENOG4105VEQ Cold shock protein DDJ31_RS20500 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DDJ31_RS20505 ENOG4105CZV ABC transporter DDJ31_RS20525 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS20530 ENOG4105BZU Histidine kinase DDJ31_RS20570 ENOG4108762 serine threonine protein kinase DDJ31_RS20580 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A DDJ31_RS20610 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) DDJ31_RS20630 ENOG4105DF6 Fe-S oxidoreductase DDJ31_RS20640 ENOG4105CFG Acts as a chaperone (By similarity) DDJ31_RS20645 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DDJ31_RS20650 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DDJ31_RS20655 ENOG4105KNI merR family transcriptional Regulator DDJ31_RS20660 ENOG4105DFW ABC transporter DDJ31_RS20695 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DDJ31_RS20735 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DDJ31_RS20750 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DDJ31_RS20755 ENOG4107RCW fructose-bisphosphate aldolase DDJ31_RS20790 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS20805 ENOG4105DIM ABC transporter DDJ31_RS20810 ENOG4105CIG ABC transporter DDJ31_RS20825 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DDJ31_RS20835 ENOG4105DWV Homoserine O-trans-acetylase DDJ31_RS20845 ENOG4105DZ6 Band 7 protein DDJ31_RS20880 ENOG4105DRR Transcriptional regulator, GntR family DDJ31_RS20885 ENOG4108JPW Aminotransferase DDJ31_RS20900 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DDJ31_RS20905 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DDJ31_RS20920 ENOG4105CFH Aspartokinase DDJ31_RS20930 ENOG4105NAF rna polymerase sigma factor DDJ31_RS20955 ENOG4108PJD permease DDJ31_RS20995 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DDJ31_RS21020 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS21030 ENOG4105CZE histidine utilization repressor DDJ31_RS21085 ENOG4105BZ4 penicillin-binding protein DDJ31_RS21120 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DDJ31_RS21150 ENOG4105D74 hydrolase DDJ31_RS21165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DDJ31_RS21170 ENOG4107B2H carbonic anhydrase DDJ31_RS21230 ENOG4108I5C dEAD DEAH box helicase DDJ31_RS21235 ENOG4105WN5 stage II sporulation protein DDJ31_RS21240 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DDJ31_RS21245 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for DDJ31_RS21265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DDJ31_RS21270 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DDJ31_RS21275 ENOG4105C6E dna polymerase iii DDJ31_RS21305 ENOG4105C26 Dehydrogenase DDJ31_RS21315 ENOG4105CHR reductase DDJ31_RS21320 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS21325 ENOG4105ENE Histidine kinase DDJ31_RS21330 ENOG4105IIP Membrane DDJ31_RS21340 ENOG410900P UPF0336 protein DDJ31_RS21435 ENOG4105C2M dna polymerase I DDJ31_RS21470 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DDJ31_RS21475 ENOG4105KDC 50s ribosomal protein l28 DDJ31_RS21480 ENOG4105W0E 50S ribosomal protein L33 DDJ31_RS21485 ENOG4105NRA 50s ribosomal protein l31 type b DDJ31_RS21495 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DDJ31_RS21515 ENOG4105C26 Dehydrogenase DDJ31_RS21535 ENOG4105CVK Glutamate decarboxylase DDJ31_RS21540 ENOG4105VCT ion-transport protein YfeO DDJ31_RS21545 ENOG41082VC UPF0145 protein DDJ31_RS21560 ENOG4105F0N pyrophosphate phospho-hydrolase DDJ31_RS21575 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DDJ31_RS21580 ENOG4108UGV hypoxanthine phosphoribosyltransferase DDJ31_RS21590 ENOG4105EUJ GTP cyclohydrolase i DDJ31_RS21600 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DDJ31_RS21620 ENOG4105CRK lysyL-tRNA synthetase DDJ31_RS21645 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS21660 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS21680 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DDJ31_RS21690 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DDJ31_RS21695 ENOG4108IYU L-aspartate oxidase DDJ31_RS21705 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DDJ31_RS21750 ENOG4105DR5 peptidase DDJ31_RS21755 ENOG4108IG5 Transcriptional regulator DDJ31_RS21760 ENOG4105C0R drug resistance transporter emrb qaca subfamily DDJ31_RS21765 ENOG4105JQZ Methyltransferase DDJ31_RS21770 ENOG4108FKE two-component system sensor kinase DDJ31_RS21775 ENOG4108PYU two-component system response regulator DDJ31_RS21780 ENOG41075QH Lipoprotein CseA DDJ31_RS21785 ENOG4105NAF rna polymerase sigma factor DDJ31_RS21800 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DDJ31_RS21815 ENOG4108JWX DDJ31_RS21820 ENOG4107R33 ppx gppa phosphatase DDJ31_RS21825 ENOG4105EY0 Xylose isomerase domain protein TIM barrel DDJ31_RS21835 ENOG4105C01 Dihydroxy-acid dehydratase DDJ31_RS21855 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS21860 ENOG4105CHH sulfate transporter DDJ31_RS21865 ENOG4105CJ1 ABC, transporter DDJ31_RS21875 ENOG4105II7 pyrroline-5-carboxylate reductase DDJ31_RS21885 ENOG4105ECQ AraC Family Transcriptional Regulator DDJ31_RS21890 ENOG4105C31 Tryptophanyl-tRNA synthetase DDJ31_RS21910 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DDJ31_RS21925 ENOG4105DGU Histone deacetylase DDJ31_RS21935 ENOG4108XFF DDJ31_RS21980 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DDJ31_RS21985 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DDJ31_RS21990 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DDJ31_RS21995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DDJ31_RS22000 ENOG4105D52 delta-aminolevulinic acid dehydratase DDJ31_RS22010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DDJ31_RS22020 ENOG4105C75 arginyL-tRNA synthetase DDJ31_RS22025 ENOG4105DK7 lysyl-tRNA synthetase DDJ31_RS22045 ENOG4105E0Y RtcB Protein DDJ31_RS22060 ENOG4105KK4 UPF0060 membrane protein DDJ31_RS22070 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DDJ31_RS22075 ENOG4108UZX fmn reductase DDJ31_RS22080 ENOG4105ETX regulatoR DDJ31_RS22100 ENOG41060GW DDJ31_RS22130 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DDJ31_RS22135 ENOG4108RH7 phosphoglycerate mutase DDJ31_RS22150 ENOG4107QIV Cytochrome c biogenesis protein DDJ31_RS22155 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) DDJ31_RS22160 ENOG4105CRE cytochrome C DDJ31_RS22180 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS22185 ENOG4105CHR reductase DDJ31_RS22195 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DDJ31_RS22210 ENOG4105DVY radical SAM domain protein DDJ31_RS22215 ENOG4105EW9 transcriptional regulator AsnC family DDJ31_RS22220 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DDJ31_RS22235 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DDJ31_RS22245 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DDJ31_RS22250 ENOG4105VEQ Cold shock protein DDJ31_RS22255 ENOG4105EV6 Pfam:DUF178 DDJ31_RS22260 ENOG4105EC2 ftsk spoIIIe DDJ31_RS22325 ENOG4108EHY type IV secretion system DDJ31_RS22375 ENOG4105CNA YD repeat protein DDJ31_RS22390 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) DDJ31_RS22395 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) DDJ31_RS22405 ENOG4108NNZ chitinase DDJ31_RS22425 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS22445 ENOG41068JE domain protein DDJ31_RS22455 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22460 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DDJ31_RS22465 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22475 ENOG4107QIZ NADH dehydrogenase DDJ31_RS22480 ENOG4108IEH NADH dehydrogenase subunit g DDJ31_RS22485 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) DDJ31_RS22490 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22495 ENOG41087XN oxidoreductase DDJ31_RS22500 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22505 ENOG4105D65 subunit l DDJ31_RS22515 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22520 ENOG4105C9U ATP-dependent DNA helicase RecQ DDJ31_RS22535 ENOG4108K01 transcriptional regulator DDJ31_RS22560 ENOG4105CAY ferredoxin--nadp reductase DDJ31_RS22565 ENOG410667J hydrolase DDJ31_RS22580 ENOG4105DUX Transporter DDJ31_RS22595 ENOG4105CJ1 ABC, transporter DDJ31_RS22635 ENOG4105ECR NmrA family DDJ31_RS22640 ENOG4105KVH Transcriptional regulator DDJ31_RS22645 ENOG4105DQU oxidoreductase, subunit beta DDJ31_RS22650 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DDJ31_RS22670 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DDJ31_RS22680 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DDJ31_RS22685 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) DDJ31_RS22690 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22700 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22710 ENOG4105C8S subunit m DDJ31_RS22715 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DDJ31_RS22720 ENOG4105D0M Protease HtpX homolog DDJ31_RS22725 ENOG410901E Membrane DDJ31_RS22735 ENOG4105Y3U Transglycosylase-associated protein DDJ31_RS22740 ENOG4108VPT UPF0234 protein DDJ31_RS22780 ENOG4105WDJ 50S ribosomal protein L33 DDJ31_RS22785 ENOG410900P UPF0336 protein DDJ31_RS22805 ENOG4107R4N Cell wall formation (By similarity) DDJ31_RS22815 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DDJ31_RS22835 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DDJ31_RS22840 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DDJ31_RS22845 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DDJ31_RS22855 ENOG4108VZM 50s ribosomal protein L10 DDJ31_RS22865 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DDJ31_RS22870 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DDJ31_RS22880 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DDJ31_RS22885 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DDJ31_RS22890 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DDJ31_RS22895 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DDJ31_RS22905 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DDJ31_RS22910 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DDJ31_RS22915 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DDJ31_RS22920 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DDJ31_RS22925 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DDJ31_RS22930 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DDJ31_RS22935 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DDJ31_RS22940 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DDJ31_RS22945 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DDJ31_RS22950 ENOG41082SA 50s ribosomal protein l29 DDJ31_RS22955 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DDJ31_RS22960 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DDJ31_RS22965 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DDJ31_RS22970 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DDJ31_RS22975 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DDJ31_RS22980 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DDJ31_RS22985 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DDJ31_RS22990 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DDJ31_RS22995 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DDJ31_RS23000 ENOG410849U 50S ribosomal protein L30 DDJ31_RS23005 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DDJ31_RS23015 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DDJ31_RS23030 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DDJ31_RS23035 ENOG41067V7 50S ribosomal protein L36 DDJ31_RS23040 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DDJ31_RS23045 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DDJ31_RS23050 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DDJ31_RS23055 ENOG4108ZT0 50S ribosomal protein l17 DDJ31_RS23060 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DDJ31_RS23075 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DDJ31_RS23080 ENOG4108UJD 30S ribosomal protein S9 DDJ31_RS23085 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DDJ31_RS23095 ENOG4105CS9 pantothenic acid kinase DDJ31_RS23100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DDJ31_RS23105 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DDJ31_RS23120 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DDJ31_RS23125 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 DDJ31_RS23130 ENOG4108097 ATP-binding protein DDJ31_RS23150 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DDJ31_RS23160 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DDJ31_RS23165 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS23175 ENOG4108KGH TRANSCRIPTIONal DDJ31_RS23185 ENOG4105CHP RNA polymerase DDJ31_RS23205 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DDJ31_RS23210 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DDJ31_RS23225 ENOG4105DND Transcriptional regulator DDJ31_RS23230 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DDJ31_RS23240 ENOG4108MMM RNA Polymerase DDJ31_RS23250 ENOG4107QVP Dehydrogenase DDJ31_RS23255 ENOG4107QQG Dehydrogenase DDJ31_RS23260 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DDJ31_RS23270 ENOG4105D9P serine threonine protein kinase DDJ31_RS23275 ENOG4105D9P serine threonine protein kinase DDJ31_RS23280 ENOG4107TPY serine threonine protein kinase DDJ31_RS23290 ENOG4107TPY serine threonine protein kinase DDJ31_RS23295 ENOG4107S6X Glycosyl transferase, family 2 DDJ31_RS23300 ENOG4105C26 Dehydrogenase DDJ31_RS23325 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DDJ31_RS23380 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS23435 ENOG4105KKX ATPase associated with various cellular activities aaa_5 DDJ31_RS23445 ENOG4105DEG Vwa containing coxe family protein DDJ31_RS23455 ENOG4105CMV Succinyl-CoA synthetase subunit beta DDJ31_RS23485 ENOG4105DC1 bifunctional purine biosynthesis protein purh DDJ31_RS23500 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DDJ31_RS23520 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DDJ31_RS23550 ENOG4108IJ7 Glycine betaine DDJ31_RS23555 ENOG4108HQS Glycine betaine DDJ31_RS23575 ENOG4105EMU Dehydrogenase DDJ31_RS23620 ENOG4106032 Glutathionylspermidine synthase DDJ31_RS23625 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DDJ31_RS23630 ENOG4105C31 Tryptophanyl-tRNA synthetase DDJ31_RS23665 ENOG4107H3J ribonuclease DDJ31_RS23680 ENOG4107RN3 metallophosphoesterase DDJ31_RS23690 ENOG4105BZU Histidine kinase DDJ31_RS23695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS23700 ENOG4105EYF MMPL domain protein DDJ31_RS23705 ENOG4105U5Y Transcriptional regulator DDJ31_RS23745 ENOG4108J01 L-aspartate oxidase DDJ31_RS23765 ENOG4105E2D ec 3.2.1.52 DDJ31_RS23800 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) DDJ31_RS23830 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DDJ31_RS23835 ENOG4105EMU Dehydrogenase DDJ31_RS23845 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family DDJ31_RS23855 ENOG4105VEQ Cold shock protein DDJ31_RS23860 ENOG4105C1J atp-dependent rna helicase DDJ31_RS23880 ENOG4108MMM RNA Polymerase DDJ31_RS23895 ENOG4108NIW Leucine export protein LeuE DDJ31_RS23950 ENOG4105K64 Glycosyl transferase, family 2 DDJ31_RS23960 ENOG4105F0R Cytidylyltransferase DDJ31_RS23965 ENOG4105D2T synthase DDJ31_RS23980 ENOG4107RM1 amidohydrolase DDJ31_RS23985 ENOG4105DIH basic membrane DDJ31_RS23990 ENOG4105DIH basic membrane DDJ31_RS23995 ENOG4108JQ9 ABC transporter DDJ31_RS24035 ENOG4105D94 Major Facilitator Superfamily DDJ31_RS24040 ENOG4107RSM transcriptional regulator DDJ31_RS24050 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DDJ31_RS24075 ENOG41065SU Two-component system sensor kinase DDJ31_RS24080 ENOG4108KXV response regulator DDJ31_RS24085 ENOG4105NAF rna polymerase sigma factor DDJ31_RS24100 ENOG4105C26 Dehydrogenase DDJ31_RS24105 ENOG4105C26 Dehydrogenase DDJ31_RS24110 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DDJ31_RS24120 ENOG4105EEM helicase DDJ31_RS24130 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain DDJ31_RS24160 ENOG4108JIK carboxylase DDJ31_RS24170 ENOG4107WR6 Maf-like protein DDJ31_RS24180 ENOG4105D8K carboxyl transferase DDJ31_RS24190 ENOG4108QER Adenylate cyclase DDJ31_RS24195 ENOG4105E39 Enoyl-CoA hydratase DDJ31_RS24200 ENOG4105KDM Diguanylate cyclase with gaf sensor DDJ31_RS24205 ENOG4105C84 Histidine ammonia-lyase DDJ31_RS24235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDJ31_RS24250 ENOG4105DQ4 alcohol dehydrogenase DDJ31_RS24255 ENOG4105TVJ transport system, permease DDJ31_RS24260 ENOG4105DQ5 transport system permease protein DDJ31_RS24315 ENOG4105NAF rna polymerase sigma factor DDJ31_RS24320 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DDJ31_RS24325 ENOG4105C7B Threonine dehydratase DDJ31_RS24340 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DDJ31_RS24350 ENOG4105T1M mycothiol conjugate amidase mca DDJ31_RS24400 ENOG4108VWQ crispr-associated protein DDJ31_RS24430 ENOG4105C7Z Conserved Protein DDJ31_RS24475 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) DDJ31_RS24490 ENOG4105CHM Aminotransferase DDJ31_RS24515 ENOG4108FUF Transcriptional regulator, IclR family DDJ31_RS24520 ENOG4105KME endoribonuclease L-psp DDJ31_RS24525 ENOG4105C6Z Gluconate DDJ31_RS24605 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS24650 ENOG4105F2W methyltransferase DDJ31_RS24655 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DDJ31_RS24660 ENOG4108IAB Phoh family DDJ31_RS24680 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DDJ31_RS24700 ENOG4105BZ4 penicillin-binding protein DDJ31_RS24705 ENOG4105CH6 catalase DDJ31_RS24720 ENOG4105C9Q fumarate hydratase class II DDJ31_RS24725 ENOG4107GFK fumarate DDJ31_RS24735 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DDJ31_RS24750 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) DDJ31_RS24760 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DDJ31_RS24770 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DDJ31_RS24785 ENOG4105C3G gtp-binding protein DDJ31_RS24800 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DDJ31_RS24835 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) DDJ31_RS24840 ENOG4105KVH Transcriptional regulator DDJ31_RS24845 ENOG4105C57 major facilitator superfamily DDJ31_RS24905 ENOG4105E33 succinate dehydrogenase DDJ31_RS24910 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) DDJ31_RS24930 ENOG4105CI3 gtp-binding protein typa DDJ31_RS24935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS24940 ENOG4108J59 Extracellular solute-binding protein, family 5 DDJ31_RS24955 ENOG4108JQ7 (ABC) transporter DDJ31_RS24960 ENOG4108JQ7 (ABC) transporter DDJ31_RS24975 ENOG4105DEF Extracellular solute-binding protein, family 5 DDJ31_RS24980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS24990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DDJ31_RS24995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS25000 ENOG4105C3U ABC transporter DDJ31_RS25005 ENOG4108JQ7 (ABC) transporter DDJ31_RS25035 ENOG4108M15 ABC transporter DDJ31_RS25045 ENOG4105BZU Histidine kinase DDJ31_RS25050 ENOG4108S01 response regulator DDJ31_RS25065 ENOG4108Z4U Ferredoxin DDJ31_RS25085 ENOG4107R4C succinyl-diaminopimelate desuccinylase DDJ31_RS25090 ENOG4108URH decarboxylase DDJ31_RS25095 ENOG4105EEI dihydropteroate synthase DDJ31_RS25105 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DDJ31_RS25110 ENOG4105CGU Enoyl-CoA hydratase DDJ31_RS25125 ENOG4105DU6 RNA polymerase DDJ31_RS25135 ENOG4105C0H protease DDJ31_RS25140 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) DDJ31_RS25175 ENOG4105D7N magnesium and cobalt transport protein CorA DDJ31_RS25185 ENOG4105DXB Major Facilitator superfamily DDJ31_RS25200 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DDJ31_RS25220 ENOG4105C1J atp-dependent rna helicase DDJ31_RS25260 ENOG4105DEF Extracellular solute-binding protein, family 5 DDJ31_RS25330 ENOG4105C4R Atp-dependent dna helicase DDJ31_RS25335 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DDJ31_RS25340 ENOG4105E09 nadh pyrophosphatase DDJ31_RS25360 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DDJ31_RS25370 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DDJ31_RS25425 ENOG41063PX domain protein DDJ31_RS25435 ENOG4105DJZ UPF0182 protein DDJ31_RS25465 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DDJ31_RS25485 ENOG4107TK4 histidinol-phosphate phosphatase DDJ31_RS25495 ENOG4105KPY Small multidrug resistance protein DDJ31_RS25500 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DDJ31_RS25505 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DDJ31_RS25515 ENOG4108RAV Conserved protein DDJ31_RS25525 ENOG4105EMN RNA polymerase sigma factor DDJ31_RS25530 ENOG4105WMN AntiSigma factor DDJ31_RS25535 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DDJ31_RS25550 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DDJ31_RS25560 ENOG41068W2 Cytochrome p-450 DDJ31_RS25580 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DDJ31_RS25585 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DDJ31_RS25600 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS25620 ENOG4105D17 glycoside hydrolase, family 3 domain protein DDJ31_RS25625 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DDJ31_RS25640 ENOG4105CBD Diacylglycerol kinase DDJ31_RS25680 ENOG4105ESN nucleotide-binding protein DDJ31_RS25710 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS25715 ENOG4108VEQ Superoxide dismutase DDJ31_RS25730 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DDJ31_RS25735 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS25750 ENOG4105C6K Malic enzyme DDJ31_RS25755 ENOG4105CB2 alcohol dehydrogenase DDJ31_RS25790 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DDJ31_RS25795 ENOG4105EB3 Histidine kinase DDJ31_RS25800 ENOG4108PYU two-component system response regulator DDJ31_RS25820 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DDJ31_RS25865 ENOG4105ZXU NLP P60 protein DDJ31_RS25890 ENOG4105CJN penicillin-binding protein DDJ31_RS25930 ENOG4105FDF Could be involved in DNA repair (By similarity) DDJ31_RS25950 ENOG4105C75 arginyL-tRNA synthetase DDJ31_RS25955 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DDJ31_RS25960 ENOG4105D6E homoserine dehydrogenase DDJ31_RS25965 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DDJ31_RS25970 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DDJ31_RS25985 ENOG4105VFB Binds the 23S rRNA (By similarity) DDJ31_RS25990 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DDJ31_RS25995 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DDJ31_RS26005 ENOG4107ZF2 Phosphatase DDJ31_RS26010 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DDJ31_RS26020 ENOG4105Z3P ATP synthase DDJ31_RS26030 ENOG4105ZA1 atp synthase DDJ31_RS26035 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DDJ31_RS26040 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DDJ31_RS26045 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DDJ31_RS26050 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DDJ31_RS26055 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DDJ31_RS26060 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DDJ31_RS26080 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS26095 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) DDJ31_RS26130 ENOG4105CJ1 ABC, transporter DDJ31_RS26145 ENOG4108ZVT methylmalonyl-coA epimerase DDJ31_RS26150 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS26170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS26175 ENOG4106F60 Histidine kinase DDJ31_RS26220 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) DDJ31_RS26285 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DDJ31_RS26290 ENOG4105C6K Malic enzyme DDJ31_RS26295 ENOG4105CTQ phosphohexokinase DDJ31_RS26320 ENOG4108MRH transcriptional regulatory protein DDJ31_RS26325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DDJ31_RS26330 ENOG4107QJT sodium dicarboxylate symporter DDJ31_RS26340 ENOG4105C57 major facilitator superfamily DDJ31_RS26345 ENOG4108Z6Z Transcriptional regulator DDJ31_RS26360 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DDJ31_RS26375 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) DDJ31_RS26380 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin DDJ31_RS26385 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) DDJ31_RS26405 ENOG4105BZ1 (ABC) transporter DDJ31_RS26410 ENOG4105BZ1 (ABC) transporter DDJ31_RS26415 ENOG4105BZ1 (ABC) transporter DDJ31_RS26420 ENOG4105BZ1 (ABC) transporter DDJ31_RS26430 ENOG4105S7A ErfK ybiS ycfS ynhG family protein DDJ31_RS26435 ENOG4107UBC ErfK ybiS ycfS ynhG family protein DDJ31_RS26475 ENOG4105DKW ABC transporter DDJ31_RS26485 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) DDJ31_RS26490 ENOG4107YXZ hydrolase, family 25 DDJ31_RS26515 ENOG4108ZT1 Transcriptional regulator DDJ31_RS26530 ENOG4105EYF MMPL domain protein DDJ31_RS26560 ENOG4105M4P Tetr family transcriptional regulator DDJ31_RS26590 ENOG4105EJQ L-serine dehydratase DDJ31_RS26595 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DDJ31_RS26600 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DDJ31_RS26605 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DDJ31_RS26625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS26655 ENOG4105EN6 Membrane DDJ31_RS26680 ENOG4105YIP Tetr family transcriptional regulator DDJ31_RS26705 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DDJ31_RS26715 ENOG4108URH decarboxylase DDJ31_RS26720 ENOG4105EMU Dehydrogenase DDJ31_RS26730 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DDJ31_RS26735 ENOG4105BZU Histidine kinase DDJ31_RS26740 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DDJ31_RS26745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DDJ31_RS26755 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DDJ31_RS26760 ENOG4105D9U N-acetyltransferase DDJ31_RS26795 ENOG4105BZU Histidine kinase DDJ31_RS26805 ENOG4108ZP8 Acetolactate synthase small subunit DDJ31_RS26810 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DDJ31_RS26815 ENOG4108JQ1 Dehydrogenase DDJ31_RS26825 ENOG41062BK proline dehydrogenase DDJ31_RS26830 ENOG4105C26 Dehydrogenase DDJ31_RS26840 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DDJ31_RS26845 ENOG4105CM2 brancheD-chain amino acid aminotransferase DDJ31_RS26850 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DDJ31_RS26875 ENOG4106AM8 polysaccharide lyase family 8 DDJ31_RS26880 ENOG4105D8K carboxyl transferase DDJ31_RS26900 ENOG4105GWZ Roadblock lc7 family protein DDJ31_RS26920 ENOG4105GWZ Roadblock lc7 family protein DDJ31_RS26935 ENOG4105ERH Fumarylacetoacetate hydrolase DDJ31_RS26940 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DDJ31_RS26975 ENOG41069M3 Transcriptional regulator DDJ31_RS26980 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DDJ31_RS26985 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DDJ31_RS26995 ENOG4105K70 DNA-binding protein DDJ31_RS27015 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DDJ31_RS27020 ENOG4105CPF Cell wall formation (By similarity) DDJ31_RS27040 ENOG4105DWF phosphomethylpyrimidine kinase DDJ31_RS27045 ENOG4105VB9 50S ribosomal protein l28 DDJ31_RS27050 ENOG4105DP4 dak2 domain fusion protein ylov DDJ31_RS27075 ENOG4106H78 methyltransferase DDJ31_RS27080 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DDJ31_RS27095 ENOG41084BZ 50S ribosomal protein L32 DDJ31_RS27100 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DDJ31_RS27105 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DDJ31_RS27110 ENOG4105KVH Transcriptional regulator DDJ31_RS27115 ENOG4105K4I Scp-like extracellular DDJ31_RS27120 ENOG4108375 Acylphosphatase (EC 3.6.1.7) DDJ31_RS27130 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DDJ31_RS27170 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) DDJ31_RS27180 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DDJ31_RS27190 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) DDJ31_RS27200 ENOG4105K5M 30s ribosomal protein S16 DDJ31_RS27205 ENOG41082KU UPF0109 protein DDJ31_RS27210 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DDJ31_RS27215 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DDJ31_RS27220 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DDJ31_RS27225 ENOG4105C3F Signal peptidase i DDJ31_RS27235 ENOG4107QYR Signal peptidase i DDJ31_RS27255 ENOG41080R2 UPF0102 protein DDJ31_RS27270 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS27285 ENOG4105CE9 30S ribosomal protein S2 DDJ31_RS27290 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DDJ31_RS27295 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DDJ31_RS27300 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DDJ31_RS27305 ENOG4105KNE Phosphatidate cytidylyltransferase DDJ31_RS27310 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DDJ31_RS27320 ENOG4108I5D sulfate abc transporter DDJ31_RS27325 ENOG4108UCS ABC, transporter DDJ31_RS27350 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DDJ31_RS27355 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DDJ31_RS27365 ENOG4105C26 Dehydrogenase DDJ31_RS27375 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DDJ31_RS27380 ENOG4108IND Tetr family transcriptional regulator DDJ31_RS27395 ENOG4105GAK amidohydrolase 2 DDJ31_RS27400 ENOG4105KHM amidohydrolase 2 DDJ31_RS27405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS27410 ENOG4105BZU Histidine kinase DDJ31_RS27445 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DDJ31_RS27470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS27475 ENOG4105F38 ABC transporter, permease DDJ31_RS27480 ENOG4105D38 putrescine abc transporter DDJ31_RS27485 ENOG4105CJP fad dependent oxidoreductase DDJ31_RS27530 ENOG4105E0S extracellular solute-binding protein family 1 DDJ31_RS27540 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DDJ31_RS27580 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DDJ31_RS27585 ENOG4105DZP Membrane-associated zinc metalloprotease DDJ31_RS27590 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DDJ31_RS27605 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DDJ31_RS27610 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase DDJ31_RS27625 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) DDJ31_RS27640 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DDJ31_RS27650 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DDJ31_RS27655 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DDJ31_RS27680 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DDJ31_RS27685 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DDJ31_RS27690 ENOG4105C1V Peptidase, M16 DDJ31_RS27695 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DDJ31_RS27715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DDJ31_RS27720 ENOG4105CN5 Metallo-Beta-Lactamase DDJ31_RS27755 ENOG4105BZU Histidine kinase DDJ31_RS27760 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DDJ31_RS27765 ENOG4107QZI cell division protein FtsK DDJ31_RS27775 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) DDJ31_RS27785 ENOG4105CEV competence damage-inducible protein DDJ31_RS27790 ENOG4105WBV Transcriptional regulator DDJ31_RS27795 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction DDJ31_RS27800 ENOG4105CHR reductase DDJ31_RS27805 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) DDJ31_RS27810 ENOG4107QRT dEAD DEAH box helicase DDJ31_RS27815 ENOG4106AXJ AraC family transcriptional regulator DDJ31_RS27840 ENOG4105DSF transport protein DDJ31_RS27845 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DDJ31_RS27870 ENOG4105DRP amino acid AbC transporter DDJ31_RS27875 ENOG4108Q1T ABC transporter DDJ31_RS27880 ENOG4107UBR Extracellular solute-binding protein family 3 DDJ31_RS27885 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS27890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS27895 ENOG4105EB3 Histidine kinase DDJ31_RS27900 ENOG4105H1G trap transporter solute receptor taxi family DDJ31_RS27920 ENOG4105BZU Histidine kinase DDJ31_RS27925 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS27935 ENOG4105PNM synthesis protein DDJ31_RS27960 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DDJ31_RS27980 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DDJ31_RS27990 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DDJ31_RS27995 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DDJ31_RS28005 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DDJ31_RS28035 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DDJ31_RS28040 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DDJ31_RS28045 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DDJ31_RS28060 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DDJ31_RS28065 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DDJ31_RS28080 ENOG4105C9U ATP-dependent DNA helicase RecQ DDJ31_RS28105 ENOG4105C6F GntR Family Transcriptional Regulator DDJ31_RS28120 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap DDJ31_RS28130 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DDJ31_RS28140 ENOG4105BZU Histidine kinase DDJ31_RS28145 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS28155 ENOG4107QN1 sodium solute DDJ31_RS28160 ENOG4108V9W transcriptional regulatory protein DDJ31_RS28170 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DDJ31_RS28180 ENOG4108MRH transcriptional regulatory protein DDJ31_RS28195 ENOG4105BZN citrate synthase DDJ31_RS28215 ENOG4107QRP cobalamin biosynthesis protein CobW DDJ31_RS28220 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DDJ31_RS28240 ENOG4105DRR Transcriptional regulator, GntR family DDJ31_RS28245 ENOG410849S phosphocarrier protein (HPr) DDJ31_RS28250 ENOG4105CD5 CoA-binding domain protein DDJ31_RS28265 ENOG4107W53 thymidine kinase DDJ31_RS28300 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DDJ31_RS28315 ENOG4105F44 Two component transcriptional regulator, winged helix family DDJ31_RS28320 ENOG4106F60 Histidine kinase DDJ31_RS28345 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DDJ31_RS28385 ENOG4107VEG TrkA-N domain protein DDJ31_RS28390 ENOG4105C0X amino acid DDJ31_RS28395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DDJ31_RS28400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DDJ31_RS28420 ENOG4105CPC Aldo Keto reductase DDJ31_RS28435 ENOG4106NZI LysR family Transcriptional regulator DDJ31_RS28460 ENOG4105ETX regulatoR DDJ31_RS28500 ENOG4105CPC Aldo Keto reductase DDJ31_RS28505 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DDJ31_RS28535 ENOG4105E6M Sulphatase-modifying factor protein DDJ31_RS28560 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DDJ31_RS28565 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DDJ31_RS28575 ENOG4105ENE Histidine kinase DDJ31_RS28580 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS28585 ENOG4105CHR reductase DDJ31_RS28625 ENOG4105DZ6 Band 7 protein DDJ31_RS28670 ENOG4105C7W Xanthine dehydrogenase DDJ31_RS28750 ENOG4107S1Q Phosphatase DDJ31_RS28765 ENOG4105CEU Arginine dihydrolase DDJ31_RS28770 ENOG4105DBV ornithine carbamoyltransferase DDJ31_RS28780 ENOG4105CGU Enoyl-CoA hydratase DDJ31_RS28800 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) DDJ31_RS28865 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DDJ31_RS28880 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) DDJ31_RS28885 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS28885 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS28890 ENOG4105DJ2 Major Facilitator Superfamily DDJ31_RS28895 ENOG41073TP transcriptional regulator DDJ31_RS28925 ENOG41082BM Transcriptional regulator, arsr family DDJ31_RS28930 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DDJ31_RS28970 ENOG4105KVH Transcriptional regulator DDJ31_RS29005 ENOG4107QPV Serine Threonine protein kinase DDJ31_RS29055 ENOG4105C5S asparaginyl-tRNA synthetase DDJ31_RS29105 ENOG4105CFI type iii restriction protein res subunit DDJ31_RS29110 ENOG4105C3J Cysteine desulfurase DDJ31_RS29125 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DDJ31_RS29325 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DDJ31_RS29345 ENOG4105VJY transcriptional regulator DDJ31_RS29365 ENOG4105E6M Sulphatase-modifying factor protein DDJ31_RS29385 ENOG4107QQG Dehydrogenase DDJ31_RS29390 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDJ31_RS29435 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DDJ31_RS29450 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DDJ31_RS29485 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DDJ31_RS29520 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DDJ31_RS29530 ENOG4107QM5 aconitate hydratase DDJ31_RS29540 ENOG4105CWX Alpha-1,2-mannosidase DDJ31_RS29545 ENOG4105I82 acetyl xylan esterase DDJ31_RS29555 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DDJ31_RS29595 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DDJ31_RS29605 ENOG4105E2R ROK family DDJ31_RS29610 ENOG4105DFW ABC transporter DDJ31_RS29615 ENOG4105C2J ABC transporter DDJ31_RS29620 ENOG4108HWW ABC transporter DDJ31_RS29625 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DDJ31_RS29630 ENOG4105CUB amino acid DDJ31_RS29660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS29665 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS29670 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS29695 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) DDJ31_RS29710 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DDJ31_RS29725 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DDJ31_RS29735 ENOG4105C1Q protoporphyrinogen oxidase DDJ31_RS29740 ENOG4107JTW chlorite dismutase DDJ31_RS29765 ENOG4105E18 UPF0276 protein DDJ31_RS29780 ENOG4105CSR polyphosphate kinase 2 DDJ31_RS29800 ENOG4107B2H carbonic anhydrase DDJ31_RS29820 ENOG4105DFU Cell wall formation (By similarity) DDJ31_RS29825 ENOG4105E0X reductase DDJ31_RS29835 ENOG4105BZU Histidine kinase DDJ31_RS29840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS29845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DDJ31_RS29860 ENOG4105EDW glycosyl transferase, family 39 DDJ31_RS29865 ENOG4108IJ8 ABC transporter DDJ31_RS29870 ENOG4105E90 ABC transporter DDJ31_RS29875 ENOG4105E90 ABC transporter DDJ31_RS29890 ENOG4105GWZ Roadblock lc7 family protein DDJ31_RS29905 ENOG4105C84 Histidine ammonia-lyase DDJ31_RS29950 ENOG41082SX arsR family transcriptional regulator DDJ31_RS29955 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DDJ31_RS29960 ENOG4108KGH TRANSCRIPTIONal DDJ31_RS29990 ENOG41064MX Tetr family transcriptional regulator DDJ31_RS30005 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein DDJ31_RS30040 ENOG4105ZSU inhibitor DDJ31_RS30085 ENOG4107R13 MMPL domain protein DDJ31_RS30095 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DDJ31_RS30105 ENOG4105E90 ABC transporter DDJ31_RS30110 ENOG4108IY8 ABC, transporter DDJ31_RS30140 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DDJ31_RS30165 ENOG4107RR1 TRANSCRIPTIONal DDJ31_RS30170 ENOG4105CSU acyl-Coa dehydrogenase DDJ31_RS30225 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS30235 ENOG4108JQ1 Dehydrogenase DDJ31_RS30240 ENOG4105EBR Carboxylesterase DDJ31_RS30245 ENOG4108J5H Homocysteine s-methyltransferase DDJ31_RS30325 ENOG4105QE3 oxidoreductase DDJ31_RS30340 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) DDJ31_RS30345 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DDJ31_RS30355 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DDJ31_RS30370 ENOG4105C7K acetolactate synthase DDJ31_RS30400 ENOG4105DRR Transcriptional regulator, GntR family DDJ31_RS30425 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding DDJ31_RS30430 ENOG4105C7N Xanthine uracil vitamin C permease DDJ31_RS30440 ENOG4108762 serine threonine protein kinase DDJ31_RS30465 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS30480 ENOG4105F4R Transcriptional regulator mode DDJ31_RS30490 ENOG4105CIS alcohol dehydrogenase DDJ31_RS30535 ENOG4107R0V Pyruvate dehydrogenase DDJ31_RS30540 ENOG4105CPP Dehydrogenase, E1 component DDJ31_RS30550 ENOG4107SQU synthase DDJ31_RS30560 ENOG4105CZS beta-ketoacyl synthase DDJ31_RS30590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DDJ31_RS30595 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DDJ31_RS30600 ENOG410846T CoA-transferase family III DDJ31_RS30605 ENOG4105CHR reductase DDJ31_RS30615 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DDJ31_RS30645 ENOG4106JDR secreted DDJ31_RS30655 ENOG4105CIR epoxide hydrolase DDJ31_RS30665 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DDJ31_RS30690 ENOG4105D29 Helix-turn-helix type 11 domain protein DDJ31_RS30715 ENOG4105DTD Dehydrogenase DDJ31_RS30745 ENOG4105CHR reductase DDJ31_RS30805 ENOG4105E0A ABC, transporter DDJ31_RS30810 ENOG4105J76 Periplasmic binding protein DDJ31_RS30815 ENOG4105S6R Iron-hydroxamate transporter permease subunit DDJ31_RS30830 ENOG410906A Beta-Ig-H3 fasciclin DDJ31_RS30865 ENOG4105CPN adenine deaminase DDJ31_RS30880 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase DDJ31_RS30895 ENOG4105F6U Short-chain dehydrogenase reductase Sdr DDJ31_RS30905 ENOG4108K8K Transcriptional regulator DDJ31_RS30910 ENOG4108IV0 ABC, transporter DDJ31_RS30915 ENOG4105C0Z ABC transporter DDJ31_RS30920 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DDJ31_RS30925 ENOG4105C32 Amino acid ABC transporter (Permease) DDJ31_RS30975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DDJ31_RS30990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DDJ31_RS30995 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DDJ31_RS31000 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS31050 ENOG4108W5M transcriptional regulator DDJ31_RS31060 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DDJ31_RS31075 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DDJ31_RS31080 ENOG4105E1F short-chain dehydrogenase reductase DDJ31_RS31095 ENOG4105NGS secreted protein DDJ31_RS31100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DDJ31_RS31120 ENOG4105CHR reductase DDJ31_RS31130 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DDJ31_RS31140 ENOG4105C9B Cysteine desulfurase DDJ31_RS31155 ENOG4108W6C Dehydrogenase DDJ31_RS31180 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS31185 ENOG4105FQP Beta-lactamase DDJ31_RS31270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDJ31_RS31275 ENOG4105ESF Peptidoglycan binding domain protein DDJ31_RS31350 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap DDJ31_RS31365 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DDJ31_RS31370 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS31380 ENOG41060W2 glyoxylate carboligase DDJ31_RS31385 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DDJ31_RS31390 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DDJ31_RS31410 ENOG4105VT2 5-hydroxyisourate hydrolase DDJ31_RS31420 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DDJ31_RS31445 ENOG4105CVJ phosphoglycerate mutase DDJ31_RS31450 ENOG4105CHM Aminotransferase DDJ31_RS31470 ENOG4105DUU IucA IucC family protein DDJ31_RS31500 ENOG4107R9S Malate synthase DDJ31_RS31515 ENOG4107HP6 Transcriptional regulator DDJ31_RS31525 ENOG4105DHG Allantoate amidinohydrolase DDJ31_RS31575 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS31585 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DDJ31_RS31600 ENOG4105CNN ABC, transporter DDJ31_RS31605 ENOG4105C2J ABC transporter DDJ31_RS31610 ENOG4105DKQ ROK family DDJ31_RS31620 ENOG4105C0D helicase DDJ31_RS31660 ENOG4107UVD Beta-phosphoglucomutase family hydrolase DDJ31_RS31670 ENOG4105E2A Dehydrogenase DDJ31_RS31675 ENOG4105BZU Histidine kinase DDJ31_RS31680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DDJ31_RS31715 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DDJ31_RS31725 ENOG4107QRI Phosphoketolase DDJ31_RS31740 ENOG4105CSR polyphosphate kinase 2 DDJ31_RS31755 ENOG4105E8R UPF0173 metal-dependent hydrolase DDJ31_RS31760 ENOG4105CIR epoxide hydrolase DDJ31_RS31770 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DDJ31_RS31775 ENOG4105E8R UPF0173 metal-dependent hydrolase DDJ31_RS31795 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS31800 ENOG4107UBR Extracellular solute-binding protein family 3 DDJ31_RS31805 ENOG4105EAD ABC transporter DDJ31_RS31810 ENOG4105DRP amino acid AbC transporter DDJ31_RS31825 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DDJ31_RS31845 ENOG4105C8Y Acetylornithine aminotransferase DDJ31_RS31860 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) DDJ31_RS31870 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DDJ31_RS31885 ENOG4105ECY inositol monophosphatase DDJ31_RS31895 ENOG4108UVJ appr-1-p processing domain protein DDJ31_RS31900 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS31910 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DDJ31_RS31915 ENOG4108R86 Transcriptional regulator DDJ31_RS31920 ENOG4105CHR reductase DDJ31_RS31955 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DDJ31_RS31965 ENOG4105BZW Glycerate kinase DDJ31_RS31975 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme DDJ31_RS31980 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS32010 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS32050 ENOG4108Q50 Histidine kinase DDJ31_RS32075 ENOG4108ME1 Peptidase M55 D-aminopeptidase DDJ31_RS32080 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DDJ31_RS32090 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DDJ31_RS32125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS32135 ENOG4105GCF PGAM DDJ31_RS32140 ENOG4105C5H ABC transporter DDJ31_RS32150 ENOG4108Z0Z intracellular protease Pfpi family DDJ31_RS32205 ENOG4105CFG Acts as a chaperone (By similarity) DDJ31_RS32230 ENOG410842T Pterin carbinolamine dehydratase DDJ31_RS32240 ENOG4105CX8 fg-gap repeat protein DDJ31_RS32250 ENOG4105CYP glycoside hydrolase, family DDJ31_RS32260 ENOG41065HY 1,4-beta-cellobiosidase DDJ31_RS32275 ENOG4105CV8 reductase DDJ31_RS32295 ENOG4107653 Transcriptional regulator DDJ31_RS32305 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DDJ31_RS32310 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DDJ31_RS32320 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DDJ31_RS32330 ENOG4105DKQ ROK family DDJ31_RS32335 ENOG4105C2J ABC transporter DDJ31_RS32340 ENOG4105CNN ABC, transporter DDJ31_RS32345 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DDJ31_RS32435 ENOG4105CMV Succinyl-CoA synthetase subunit beta DDJ31_RS32445 ENOG4105C26 Dehydrogenase DDJ31_RS32490 ENOG4105CH2 amidohydrolase DDJ31_RS32495 ENOG4105EN6 Membrane DDJ31_RS32500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DDJ31_RS32515 ENOG4105KVH Transcriptional regulator DDJ31_RS32565 ENOG4105CHR reductase DDJ31_RS32580 ENOG4105CI2 imidazolone-5-propionate hydrolase DDJ31_RS32600 ENOG4105DY8 decarboxylase DDJ31_RS32620 ENOG41082SX arsR family transcriptional regulator DDJ31_RS32635 ENOG4105C37 (CBS) domain DDJ31_RS32645 ENOG4108TGC Acyltransferase DDJ31_RS32670 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DDJ31_RS32685 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DDJ31_RS32705 ENOG4107RRN ABC transporter substrate-binding protein DDJ31_RS32710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS32735 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS32750 ENOG4107QJN gtp cyclohydrolase ii DDJ31_RS32765 ENOG410905P Pyridoxamine 5-phosphate DDJ31_RS32775 ENOG4105CSH Transporter DDJ31_RS32785 ENOG4107S9B Shikimate dehydrogenase DDJ31_RS32795 ENOG4107TB6 phosphoglycerate mutase DDJ31_RS32800 ENOG4108J5G 6-phosphogluconate dehydrogenase DDJ31_RS32805 ENOG4107QP8 phosphohexose isomerase DDJ31_RS32845 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DDJ31_RS32865 ENOG4105CNT hydrolase family 2 DDJ31_RS32885 ENOG4108MGF sugar kinase DDJ31_RS32895 ENOG4105F8D glycoside hydrolase family 4 DDJ31_RS32905 ENOG4106UDK Cellulose-binding, family II DDJ31_RS32955 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DDJ31_RS32960 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DDJ31_RS32965 ENOG4105CG3 alpha amylase, catalytic region DDJ31_RS32985 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS32995 ENOG4108IAJ Nad-dependent epimerase dehydratase DDJ31_RS33040 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DDJ31_RS33085 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DDJ31_RS33090 ENOG4105CSH Transporter DDJ31_RS33100 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DDJ31_RS33105 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase DDJ31_RS33110 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha DDJ31_RS33130 ENOG41067TZ transcriptional regulator, MarR family DDJ31_RS33145 ENOG4105DQE DNA ligase DDJ31_RS33165 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS33175 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) DDJ31_RS33185 ENOG4106V2I dimethylaminohydrolase DDJ31_RS33190 ENOG4105C5H ABC transporter DDJ31_RS33210 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) DDJ31_RS33220 ENOG4105EG6 Saccharopine dehydrogenase DDJ31_RS33225 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DDJ31_RS33230 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS33235 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS33240 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS33270 ENOG4105C5H ABC transporter DDJ31_RS33275 ENOG4105BZM domain protein DDJ31_RS33305 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DDJ31_RS33325 ENOG4108MDK Dehydrogenase DDJ31_RS33345 ENOG4105EY8 ABC transporter DDJ31_RS33350 ENOG4105FBD synthase DDJ31_RS33365 ENOG4107S11 squalene-associated FAD-dependent desaturase DDJ31_RS33375 ENOG4105EWU Squalene--hopene cyclase DDJ31_RS33390 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DDJ31_RS33395 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DDJ31_RS33425 ENOG41090WU lipolytic protein G-D-S-L family DDJ31_RS33435 ENOG4105D82 Glutamate dehydrogenase DDJ31_RS33475 ENOG4105CBP Major Facilitator DDJ31_RS33485 ENOG4106NZI LysR family Transcriptional regulator DDJ31_RS33490 ENOG4105CPQ Dehydrogenase DDJ31_RS33500 ENOG4106NZI LysR family Transcriptional regulator DDJ31_RS33565 ENOG4105EMU Dehydrogenase DDJ31_RS33575 ENOG4107QVI Methyltransferase, type 11 DDJ31_RS33585 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS33590 ENOG41061H0 Monooxygenase DDJ31_RS33600 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DDJ31_RS33630 ENOG41060BG Tetr family transcriptional regulator DDJ31_RS33635 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) DDJ31_RS33650 ENOG4107VIJ nudix hydrolase DDJ31_RS33685 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS33730 ENOG41082AN stage II sporulation protein DDJ31_RS33740 ENOG4107R6F Alpha Beta Hydrolase Fold protein DDJ31_RS33745 ENOG4105EBR Carboxylesterase DDJ31_RS33750 ENOG4105W1N transcriptional regulator DDJ31_RS33755 ENOG4108XEP Alpha Beta Hydrolase Fold protein DDJ31_RS33775 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) DDJ31_RS33790 ENOG4108IAJ Nad-dependent epimerase dehydratase DDJ31_RS33810 ENOG4105DKQ ROK family DDJ31_RS33820 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DDJ31_RS33830 ENOG4105CNN ABC, transporter DDJ31_RS33835 ENOG4105C2J ABC transporter DDJ31_RS33850 ENOG4105CHR reductase DDJ31_RS33860 ENOG41060NJ transcriptional regulator DDJ31_RS33875 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS33900 ENOG4108QBF Transcriptional regulator DDJ31_RS33910 ENOG4105JSC dimethylmenaquinone methyltransferase DDJ31_RS33925 ENOG4105D2S major facilitator superfamily DDJ31_RS33935 ENOG4105C57 major facilitator superfamily DDJ31_RS33985 ENOG41060NJ transcriptional regulator DDJ31_RS33995 ENOG4108JQ1 Dehydrogenase DDJ31_RS34000 ENOG41082A2 Alpha beta hydrolase DDJ31_RS34055 ENOG41068W2 Cytochrome p-450 DDJ31_RS34060 ENOG4108PA7 Methyltransferase DDJ31_RS34085 ENOG4105C57 major facilitator superfamily DDJ31_RS34095 ENOG4105CHF Glutathione S-transferase DDJ31_RS34105 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS34130 ENOG4106S2D Transcriptional regulator DDJ31_RS34140 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin DDJ31_RS34155 ENOG4106A3M Cytochrome p-450 DDJ31_RS34165 ENOG4105E9K Isocitrate dehydrogenase DDJ31_RS34170 ENOG4105D64 Mechanosensitive ion channel DDJ31_RS34180 ENOG4105BZ1 (ABC) transporter DDJ31_RS34185 ENOG4105F0K SARP family transcriptional regulator DDJ31_RS34215 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DDJ31_RS34220 ENOG4105MS9 Resuscitation-promoting factor DDJ31_RS34235 ENOG4107QPH glycogen) synthase DDJ31_RS34240 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DDJ31_RS34245 ENOG4105CNN ABC, transporter DDJ31_RS34250 ENOG4107R9N ABC transporter DDJ31_RS34255 ENOG4105C2J ABC transporter DDJ31_RS34260 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DDJ31_RS34265 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS34280 ENOG4105CWX Alpha-1,2-mannosidase DDJ31_RS34325 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS34410 ENOG4105CRK lysyL-tRNA synthetase DDJ31_RS34415 ENOG4108ZJ4 polysaccharide deacetylase DDJ31_RS34455 ENOG4105BZU Histidine kinase DDJ31_RS34460 ENOG4105C5Q Transcriptional regulator DDJ31_RS34475 ENOG4105E33 succinate dehydrogenase DDJ31_RS34495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DDJ31_RS34500 ENOG4105DEN Luciferase family DDJ31_RS34505 ENOG4105CKI cobalamin synthesis protein DDJ31_RS34510 ENOG41068HZ 50S ribosomal protein L32 DDJ31_RS34525 ENOG4105WKW Pfam:DUF1458 DDJ31_RS34535 ENOG41067HS methyltransferase DDJ31_RS34540 ENOG4108V75 Glutamine amidotransferase DDJ31_RS34545 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process DDJ31_RS34550 ENOG4105D1K glutamate--cysteine ligase DDJ31_RS34560 ENOG4105DZ6 Band 7 protein DDJ31_RS34585 ENOG41062IR nudix hydrolase DDJ31_RS34625 ENOG4105CHR reductase DDJ31_RS34630 ENOG4105FB2 class II Aldolase DDJ31_RS34645 ENOG4105C6Z Gluconate DDJ31_RS34650 ENOG4105MVE transcriptional regulator DDJ31_RS34655 ENOG4105CV8 reductase DDJ31_RS34660 ENOG4105F27 Major Facilitator DDJ31_RS34715 ENOG41060NJ transcriptional regulator DDJ31_RS34720 ENOG41080RH Thioredoxin DDJ31_RS34725 ENOG4105DC8 reductase DDJ31_RS34730 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DDJ31_RS34745 ENOG4105EUB pirin domain protein DDJ31_RS34755 ENOG410846T CoA-transferase family III DDJ31_RS34760 ENOG4105DYW oxidoreductase DDJ31_RS34765 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS34770 ENOG4105CHU acetyl-coa acetyltransferase DDJ31_RS34775 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DDJ31_RS34785 ENOG4105C1G acyl-Coa dehydrogenase DDJ31_RS34790 ENOG4105MKU Transcriptional regulator DDJ31_RS34810 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) DDJ31_RS34835 ENOG4108Z6Z Transcriptional regulator DDJ31_RS34885 ENOG4105EMU Dehydrogenase DDJ31_RS34910 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN DDJ31_RS34950 ENOG4108TCJ secreted hydrolase DDJ31_RS34960 ENOG41087PP glycosyltransferase MGT family DDJ31_RS35000 ENOG4105D0M Protease HtpX homolog DDJ31_RS35025 ENOG4105CHP RNA polymerase DDJ31_RS35030 ENOG4105GRZ Ycii-related protein DDJ31_RS35045 ENOG4105C57 major facilitator superfamily DDJ31_RS35050 ENOG4108JGH Tetr family transcriptional regulator DDJ31_RS35060 ENOG4105MWK D-amino acid dehydrogenase, small subunit DDJ31_RS35115 ENOG4105CPP Dehydrogenase, E1 component DDJ31_RS35120 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 DDJ31_RS35135 ENOG4105CQS hydrogenase expression formation protein HypD DDJ31_RS35170 ENOG41083MR nifu domain-containing protein DDJ31_RS35175 ENOG4105DPX Hydrogenase, large subunit DDJ31_RS35190 ENOG4107RSS Hydrogenase accessory protein HypB DDJ31_RS35210 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DDJ31_RS35260 ENOG4107TB5 TRANSCRIPTIONal DDJ31_RS35285 ENOG4108FN7 Aldo keto reductase DDJ31_RS35305 ENOG4105WWK YheO domain protein DDJ31_RS35315 ENOG4105CHR reductase DDJ31_RS35325 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB DDJ31_RS35335 ENOG4105E90 ABC transporter DDJ31_RS35340 ENOG4105E90 ABC transporter DDJ31_RS35345 ENOG4108HQR Glycine betaine DDJ31_RS35350 ENOG4108IJ8 ABC transporter DDJ31_RS35355 ENOG41080R8 Conserved Protein DDJ31_RS35365 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DDJ31_RS35370 ENOG4105DET Rhamnulokinase DDJ31_RS35380 ENOG4105C9F isomerase DDJ31_RS35400 ENOG4108IG5 Transcriptional regulator DDJ31_RS35415 ENOG4105C9F isomerase DDJ31_RS35420 ENOG4105C2J ABC transporter DDJ31_RS35430 ENOG4105F5R ABC transporter DDJ31_RS35435 ENOG4105D4B ABC, transporter DDJ31_RS35450 ENOG4105ETE Transcriptional regulator (LacI family DDJ31_RS35460 ENOG4105DDN Pentapeptide repeat-containing protein DDJ31_RS35465 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DDJ31_RS35470 ENOG4108R86 Transcriptional regulator DDJ31_RS35480 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DDJ31_RS35510 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DDJ31_RS35540 ENOG4105DCG PHP domain protein DDJ31_RS35565 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DDJ31_RS35585 ENOG4105I9Z UPF0264 protein DDJ31_RS35610 ENOG4105ECQ AraC Family Transcriptional Regulator DDJ31_RS35645 ENOG4106A3M Cytochrome p-450 DDJ31_RS35650 ENOG4108X7A Terpene synthase metal-binding domain-containing protein DDJ31_RS35670 ENOG4106YKD Cytochrome p-450 DDJ31_RS35685 ENOG4105F8D glycoside hydrolase family 4 DDJ31_RS35695 ENOG4105DRS transport system, permease DDJ31_RS35715 ENOG4105CPC Aldo Keto reductase DDJ31_RS35740 ENOG4105DU6 RNA polymerase DDJ31_RS35750 ENOG4105CNT hydrolase family 2 DDJ31_RS35770 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DDJ31_RS35795 ENOG4108JQ1 Dehydrogenase DDJ31_RS35825 ENOG4106NMR serine protease DDJ31_RS35855 ENOG4105CJA serine threonine protein kinase DDJ31_RS35860 ENOG4107V9E glucose-1-phosphate thymidylyltransferase DDJ31_RS35870 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DDJ31_RS35880 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DDJ31_RS35895 ENOG41080V3 Major Facilitator superfamily DDJ31_RS35930 ENOG4105BZ9 Cytochrome C oxidase, subunit I DDJ31_RS36020 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DDJ31_RS36025 ENOG4105E2R ROK family DDJ31_RS36060 ENOG41067SE Tetr family transcriptional regulator DDJ31_RS36095 ENOG4105RD7 BadF BadG BcrA BcrD DDJ31_RS36105 ENOG410769Z extracellular solute-binding protein family 1 DDJ31_RS36110 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DDJ31_RS36115 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DDJ31_RS36125 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS36140 ENOG4105D9G High-affinity DDJ31_RS36225 ENOG4105EYF MMPL domain protein DDJ31_RS36250 ENOG4108Q9V regulatoR DDJ31_RS36255 ENOG4105G9B Transcriptional regulator DDJ31_RS36260 ENOG4108IV0 ABC, transporter DDJ31_RS36265 ENOG4105C0Z ABC transporter DDJ31_RS36270 ENOG4105C32 Amino acid ABC transporter (Permease) DDJ31_RS36275 ENOG4105C32 Amino acid ABC transporter (Permease) DDJ31_RS36285 ENOG4108FN7 Aldo keto reductase DDJ31_RS36290 ENOG4105BZ1 (ABC) transporter DDJ31_RS36300 ENOG4105ECQ AraC Family Transcriptional Regulator DDJ31_RS36350 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DDJ31_RS36360 ENOG4105HSS phospholipase C DDJ31_RS36380 ENOG4105DAE Methylenetetrahydrofolate reductase DDJ31_RS36385 ENOG41066UM arsR family transcriptional regulator DDJ31_RS36390 ENOG4105C59 p-type ATPase DDJ31_RS36395 ENOG4105C26 Dehydrogenase DDJ31_RS36405 ENOG4105E39 Enoyl-CoA hydratase DDJ31_RS36420 ENOG4105CFF transcriptional regulator DDJ31_RS36430 ENOG4105CR4 methylisocitrate lyase DDJ31_RS36450 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DDJ31_RS36465 ENOG4107R9S Malate synthase DDJ31_RS36500 ENOG4107TE5 Lipid kinase DDJ31_RS36545 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DDJ31_RS36550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS36560 ENOG4105F38 ABC transporter, permease DDJ31_RS36570 ENOG4108TZY GntR Family Transcriptional Regulator DDJ31_RS36575 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DDJ31_RS36580 ENOG4105CWX Alpha-1,2-mannosidase DDJ31_RS36600 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DDJ31_RS36605 ENOG4105EZM VWA-like domain (DUF2201) DDJ31_RS36620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DDJ31_RS36640 ENOG4105E3W Two component transcriptional regulator (Winged helix family DDJ31_RS36680 ENOG4105CV8 reductase DDJ31_RS36715 ENOG4107RTD sua5 ycio yrdc ywlc family protein DDJ31_RS36770 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DDJ31_RS36785 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS36790 ENOG4105BZU Histidine kinase DDJ31_RS36820 ENOG4105CPC Aldo Keto reductase DDJ31_RS36865 ENOG4108MGF sugar kinase DDJ31_RS36870 ENOG4105KVH Transcriptional regulator DDJ31_RS36910 ENOG4106A3M Cytochrome p-450 DDJ31_RS36915 ENOG4105DFW ABC transporter DDJ31_RS37005 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DDJ31_RS37015 ENOG4105BZU Histidine kinase DDJ31_RS37030 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) DDJ31_RS37035 ENOG4108YYD acetyltransferase DDJ31_RS37045 ENOG4105JSC dimethylmenaquinone methyltransferase DDJ31_RS37055 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DDJ31_RS37060 ENOG4108HM4 ABC transporter DDJ31_RS37065 ENOG4105D38 putrescine abc transporter DDJ31_RS37070 ENOG4105F38 ABC transporter, permease DDJ31_RS37160 ENOG4105KKX ATPase associated with various cellular activities aaa_5 DDJ31_RS37180 ENOG4108HUF Transporter DDJ31_RS37245 ENOG4105CAQ asparagine synthetase DDJ31_RS37250 ENOG4107QN1 sodium solute DDJ31_RS37275 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DDJ31_RS37280 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DDJ31_RS37285 ENOG4106FTQ Taurine ABC transporter, periplasmic DDJ31_RS37290 ENOG4108IY8 ABC, transporter DDJ31_RS37325 ENOG4105CSH Transporter DDJ31_RS37365 ENOG4105VEQ Cold shock protein DDJ31_RS37375 ENOG4108KEZ Dehydrogenase DDJ31_RS37380 ENOG4105CSH Transporter DDJ31_RS37425 ENOG4105CWC Acetylornithine deacetylase DDJ31_RS37445 ENOG4105CDA abc transporter atp-binding protein DDJ31_RS37450 ENOG4105E5Q amino acid AbC transporter DDJ31_RS37455 ENOG4106PMH Extracellular solute-binding protein family 3 DDJ31_RS37495 ENOG4105DWV Homoserine O-trans-acetylase DDJ31_RS37500 ENOG4108Z86 Glutamine amidotransferase DDJ31_RS37570 ENOG4105E2R ROK family DDJ31_RS37585 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DDJ31_RS37605 ENOG4105EBR Carboxylesterase DDJ31_RS37610 ENOG4105CQB FAD linked oxidase domain protein DDJ31_RS37630 ENOG41064MX Tetr family transcriptional regulator DDJ31_RS37635 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DDJ31_RS37640 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component DDJ31_RS37645 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component DDJ31_RS37655 ENOG4105CG3 alpha amylase, catalytic region DDJ31_RS37660 ENOG4107T3P ABC, transporter DDJ31_RS37665 ENOG4105U3E Transcriptional regulator DDJ31_RS37670 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DDJ31_RS37690 ENOG4105CNN ABC, transporter DDJ31_RS37695 ENOG4105C2J ABC transporter DDJ31_RS37725 ENOG4108M4U conserved membrane protein DDJ31_RS37745 ENOG4105E0F Histidine kinase DDJ31_RS37750 ENOG4105CHR reductase DDJ31_RS37770 ENOG4105D8K carboxyl transferase DDJ31_RS37805 ENOG4107V9E glucose-1-phosphate thymidylyltransferase DDJ31_RS37830 ENOG4105CHR reductase DDJ31_RS37835 ENOG4107SCK Monooxygenase DDJ31_RS37855 ENOG4105CZS beta-ketoacyl synthase DDJ31_RS37865 ENOG4105KTE polyketide synthesis cyclase DDJ31_RS37890 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DDJ31_RS37915 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DDJ31_RS37930 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) DDJ31_RS37975 ENOG4105DEF Extracellular solute-binding protein, family 5 DDJ31_RS37980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DDJ31_RS37985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DDJ31_RS37990 ENOG4105C3U ABC transporter DDJ31_RS38010 ENOG4105CEY Amp-dependent synthetase and ligase DDJ31_RS38020 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DDJ31_RS38045 ENOG4105MXW flavin reductase domain protein, FMN-binding DDJ31_RS38080 ENOG4105D7W serine acetyltransferase DDJ31_RS38100 ENOG4105EAB amino acid AbC transporter DDJ31_RS38130 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DDJ31_RS38150 ENOG4108KSA LysR family transcriptional regulator DDJ31_RS38160 ENOG4107ZR7 Membrane DDJ31_RS38195 ENOG4108KDT Molybdate metabolism regulator DDJ31_RS38210 ENOG4105CHR reductase DDJ31_RS38220 ENOG4105WH1 Two component transcriptional regulator luxr family DDJ31_RS38235 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) DDJ31_RS38240 ENOG4108M8W Monooxygenase DDJ31_RS38245 ENOG4105E8G Major facilitator Superfamily DDJ31_RS38255 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin DDJ31_RS38270 ENOG4105CPC Aldo Keto reductase DDJ31_RS38280 ENOG4107U32 Beta-lactamase domain protein DDJ31_RS38295 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DDJ31_RS38315 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DDJ31_RS38320 ENOG4105KZ7 phosphocarrier protein hpr DDJ31_RS38330 ENOG4105FDP GntR family transcriptional regulator DDJ31_RS38335 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia DDJ31_RS38350 ENOG4105DRS transport system, permease DDJ31_RS38365 ENOG4105CSH Transporter DDJ31_RS38385 ENOG4105MP9 class II Aldolase DDJ31_RS38390 ENOG4105FQP Beta-lactamase DDJ31_RS38410 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DDJ31_RS38415 ENOG4108UYI beta-alanyl-CoA ammonia lyase DDJ31_RS38430 ENOG4108JPW Aminotransferase DDJ31_RS38450 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase DDJ31_RS38455 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) DDJ31_RS38460 ENOG4108X0B nad(p)h dehydrogenase (quinone) DDJ31_RS38470 ENOG4105EV8 ectoine hydroxylase DDJ31_RS38495 ENOG4105YVS arsR family transcriptional regulator DDJ31_RS38500 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DDJ31_RS38520 ENOG4107U8T Nadph-dependent fmn reductase DDJ31_RS38535 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DDJ31_RS38565 ENOG4108IND Tetr family transcriptional regulator