locus-tag	class	description
D6270_RS00150	COG0745	RESPONSE REGULATOR receiver
D6270_RS00205	COG0494	nUDIX hydrolase
D6270_RS00210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D6270_RS00260	COG0515	serine threonine protein kinase
D6270_RS00260	COG2815	serine threonine protein kinase
D6270_RS00345	COG0604	alcohol dehydrogenase
D6270_RS00345	COG3321	synthase
D6270_RS00350	COG1309	transcriptional regulator
D6270_RS00370	COG1191	sigma factor activity
D6270_RS00400	COG0069	glutamate synthase activity
D6270_RS00460	COG1309	transcriptional regulator
D6270_RS00465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D6270_RS00570	COG1846	Transcriptional regulator
D6270_RS00575	COG1764	response to oxidative stress
D6270_RS00605	COG0277	FAD linked oxidase domain protein
D6270_RS00615	COG1902	pentaerythritol trinitrate reductase activity
D6270_RS00620	COG0640	Transcriptional regulator
D6270_RS00625	COG1064	alcohol dehydrogenase
D6270_RS00635	COG1309	transcriptional regulator
D6270_RS00640	COG0702	epimerase
D6270_RS00675	COG0642	Histidine kinase
D6270_RS00695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D6270_RS00700	COG0366	Alpha amylase catalytic
D6270_RS00705	COG3833	ABC-type maltose transport systems, permease component
D6270_RS00710	COG1175	transmembrane transport
D6270_RS00715	COG1653	transport
D6270_RS00755	COG1349	DNA-binding transcription factor activity
D6270_RS00760	COG1105	Belongs to the carbohydrate kinase PfkB family
D6270_RS00775	COG0681	Belongs to the peptidase S26 family
D6270_RS00790	COG0596	Alpha beta hydrolase
D6270_RS00835	COG0254	rRNA binding
D6270_RS00840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6270_RS00885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D6270_RS00900	COG1024	Enoyl-CoA hydratase
D6270_RS00925	COG0765	amino acid transport
D6270_RS00945	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS00950	COG2366	antibiotic biosynthetic process
D6270_RS00960	COG2070	2-Nitropropane dioxygenase
D6270_RS00965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6270_RS01020	COG2813	Specifically methylates the guanine in position
D6270_RS01035	COG2356	endonuclease I
D6270_RS01060	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D6270_RS01075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D6270_RS01080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D6270_RS01085	COG2080	2 iron, 2 sulfur cluster binding
D6270_RS01095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS01140	COG2365	Tyrosine phosphatase family
D6270_RS01165	COG1120	ATPase activity
D6270_RS01170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6270_RS01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS01190	COG0477	Major facilitator Superfamily
D6270_RS01195	COG2382	esterase
D6270_RS01200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS01210	COG1169	isochorismate synthase
D6270_RS01215	COG1021	2,3-dihydroxybenzoate-AMP ligase
D6270_RS01220	COG1535	isochorismatase
D6270_RS01220	COG3433	isochorismatase activity
D6270_RS01225	COG3433	isochorismatase activity
D6270_RS01225	COG1535	isochorismatase
D6270_RS01230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D6270_RS01305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D6270_RS01340	COG3845	ABC transporter
D6270_RS01365	COG1470	cell adhesion involved in biofilm formation
D6270_RS01385	COG1063	alcohol dehydrogenase
D6270_RS01440	COG2382	esterase
D6270_RS01445	COG1132	(ABC) transporter
D6270_RS01455	COG1132	(ABC) transporter
D6270_RS01460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D6270_RS01465	COG1120	ATPase activity
D6270_RS01470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS01500	COG2376	Dihydroxyacetone kinase
D6270_RS01505	COG1461	Dihydroxyacetone kinase
D6270_RS01520	COG0488	(ABC) transporter
D6270_RS01550	COG1191	sigma factor activity
D6270_RS01560	COG3246	L-lysine catabolic process to acetate
D6270_RS01565	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6270_RS01580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D6270_RS01600	COG1120	ATPase activity
D6270_RS01605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS01630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6270_RS01680	COG1295	ribonuclease BN
D6270_RS01680	COG1959	2 iron, 2 sulfur cluster binding
D6270_RS01695	COG4733	cellulase activity
D6270_RS01695	COG5297	Belongs to the glycosyl hydrolase family 6
D6270_RS01715	COG1120	ATPase activity
D6270_RS01720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS01725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS01755	COG0366	Alpha amylase catalytic
D6270_RS01755	COG1874	Beta-galactosidase
D6270_RS01765	COG1609	Transcriptional regulator
D6270_RS01770	COG1172	Belongs to the binding-protein-dependent transport system permease family
D6270_RS01780	COG1129	ABC transporter
D6270_RS01785	COG1879	ABC-type sugar transport system periplasmic component
D6270_RS01805	COG3250	beta-galactosidase activity
D6270_RS01855	COG0328	RNA-DNA hybrid ribonuclease activity
D6270_RS01865	COG1132	(ABC) transporter
D6270_RS01875	COG2264	protein methyltransferase activity
D6270_RS01915	COG0477	Major facilitator Superfamily
D6270_RS01970	COG0464	growth
D6270_RS01980	COG1349	DNA-binding transcription factor activity
D6270_RS01995	COG0702	epimerase
D6270_RS02020	COG1940	carbohydrate kinase activity
D6270_RS02025	COG2223	nitrite transmembrane transporter activity
D6270_RS02055	COG0445	tRNA wobble uridine modification
D6270_RS02075	COG1660	Displays ATPase and GTPase activities
D6270_RS02105	COG1309	transcriptional regulator
D6270_RS02110	COG2409	Drug exporters of the RND superfamily
D6270_RS02115	COG1940	carbohydrate kinase activity
D6270_RS02145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D6270_RS02190	COG0584	glycerophosphoryl diester phosphodiesterase
D6270_RS02195	COG0456	acetyltransferase
D6270_RS02210	COG0671	phosphoesterase, PA-phosphatase related
D6270_RS02235	COG2226	methyltransferase
D6270_RS02260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D6270_RS02275	COG2706	6-phosphogluconolactonase activity
D6270_RS02290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D6270_RS02300	COG0667	Aldo Keto reductase
D6270_RS02305	COG3469	chitinase activity
D6270_RS02335	COG1253	flavin adenine dinucleotide binding
D6270_RS02380	COG0531	amino acid
D6270_RS02390	COG0174	glutamine synthetase
D6270_RS02395	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS02425	COG4981	capsule polysaccharide biosynthetic process
D6270_RS02445	COG2835	tetraacyldisaccharide 4'-kinase activity
D6270_RS02460	COG1802	Transcriptional regulator
D6270_RS02465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6270_RS02470	COG0402	S-adenosylhomocysteine deaminase activity
D6270_RS02480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6270_RS02485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS02490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS02495	COG2274	protein secretion by the type I secretion system
D6270_RS02500	COG1132	(ABC) transporter
D6270_RS02510	COG0243	molybdopterin cofactor binding
D6270_RS02535	COG1357	PFAM Pentapeptide repeats (8 copies)
D6270_RS02610	COG1191	sigma factor activity
D6270_RS02640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6270_RS02645	COG0542	response to heat
D6270_RS02690	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D6270_RS02695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D6270_RS02715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D6270_RS02725	COG0798	PFAM Bile acid sodium symporter
D6270_RS02740	COG1247	-acetyltransferase
D6270_RS02745	COG0640	Transcriptional regulator
D6270_RS02800	COG0443	Heat shock 70 kDa protein
D6270_RS02805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D6270_RS02820	COG0542	response to heat
D6270_RS02855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D6270_RS02865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D6270_RS02885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D6270_RS02900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D6270_RS02905	COG0516	GMP reductase activity
D6270_RS02905	COG0517	IMP dehydrogenase activity
D6270_RS02920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D6270_RS02930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D6270_RS02930	COG0617	tRNA 3'-terminal CCA addition
D6270_RS02930	COG0517	IMP dehydrogenase activity
D6270_RS02950	COG1063	alcohol dehydrogenase
D6270_RS02955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D6270_RS02960	COG1227	inorganic diphosphatase activity
D6270_RS02960	COG0517	IMP dehydrogenase activity
D6270_RS02970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D6270_RS02980	COG0574	Belongs to the PEP-utilizing enzyme family
D6270_RS02980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D6270_RS03005	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D6270_RS03010	COG1937	Protein conserved in bacteria
D6270_RS03015	COG0730	response to heat
D6270_RS03025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D6270_RS03025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6270_RS03100	COG1116	anion transmembrane transporter activity
D6270_RS03115	COG2072	flavoprotein involved in K transport
D6270_RS03125	COG1132	(ABC) transporter
D6270_RS03130	COG1846	Transcriptional regulator
D6270_RS03145	COG1132	(ABC) transporter
D6270_RS03150	COG1132	(ABC) transporter
D6270_RS03160	COG1252	NADH dehydrogenase
D6270_RS03165	COG1793	dna ligase
D6270_RS03180	COG1946	Acyl-CoA thioesterase
D6270_RS03195	COG0386	Belongs to the glutathione peroxidase family
D6270_RS03200	COG1960	acyl-CoA dehydrogenase activity
D6270_RS03210	COG0242	peptide deformylase activity
D6270_RS03220	COG3442	glutamine amidotransferase
D6270_RS03225	COG0205	6-phosphofructokinase activity
D6270_RS03235	COG0204	Acyl-transferase
D6270_RS03250	COG0829	nickel cation binding
D6270_RS03255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D6270_RS03265	COG0804	urea catabolic process
D6270_RS03270	COG0832	Belongs to the urease beta subunit family
D6270_RS03275	COG0831	urea catabolic process
D6270_RS03300	COG0740	serine-type endopeptidase activity
D6270_RS03310	COG0791	NLP P60 protein
D6270_RS03335	COG0156	8-amino-7-oxononanoate synthase activity
D6270_RS03340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D6270_RS03345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D6270_RS03350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D6270_RS03355	COG2226	methyltransferase
D6270_RS03390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D6270_RS03395	COG3663	DNA glycosylase
D6270_RS03405	COG1940	carbohydrate kinase activity
D6270_RS03410	COG2188	Transcriptional regulator
D6270_RS03415	COG1595	DNA-templated transcription, initiation
D6270_RS03430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6270_RS03455	COG0626	cystathionine gamma-synthase activity
D6270_RS03475	COG1522	sequence-specific DNA binding
D6270_RS03485	COG0420	3'-5' exonuclease activity
D6270_RS03490	COG1739	Uncharacterized protein family UPF0029
D6270_RS03495	COG1832	CoA-binding protein
D6270_RS03550	COG2188	Transcriptional regulator
D6270_RS03565	COG0739	heme binding
D6270_RS03640	COG1968	undecaprenyl-diphosphatase activity
D6270_RS03655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D6270_RS03710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D6270_RS03750	COG1733	regulation of RNA biosynthetic process
D6270_RS03765	COG1309	transcriptional regulator
D6270_RS03880	COG0697	spore germination
D6270_RS03920	COG1695	Transcriptional regulator
D6270_RS03955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D6270_RS03955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D6270_RS03985	COG1716	ATPase activity
D6270_RS04005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D6270_RS04040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D6270_RS04050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6270_RS04065	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D6270_RS04095	COG2018	Roadblock/LC7 domain
D6270_RS04165	COG2364	Membrane
D6270_RS04175	COG2270	Major facilitator Superfamily
D6270_RS04190	COG1216	Glycosyl transferase, family 2
D6270_RS04215	COG1960	acyl-CoA dehydrogenase activity
D6270_RS04250	COG0464	growth
D6270_RS04270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D6270_RS04275	COG0140	phosphoribosyl-ATP diphosphatase activity
D6270_RS04280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D6270_RS04290	COG3201	nicotinamide mononucleotide transporter
D6270_RS04310	COG0702	epimerase
D6270_RS04320	COG0738	Major facilitator superfamily
D6270_RS04325	COG2233	PERMEase
D6270_RS04345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D6270_RS04355	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS04370	COG2390	Transcriptional regulator
D6270_RS04375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D6270_RS04385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D6270_RS04400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D6270_RS04410	COG1758	RNA polymerase activity
D6270_RS04425	COG0284	orotidine-5'-phosphate decarboxylase activity
D6270_RS04430	COG0167	dihydroorotate dehydrogenase activity
D6270_RS04435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D6270_RS04440	COG0505	Belongs to the CarA family
D6270_RS04450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6270_RS04455	COG0540	Belongs to the ATCase OTCase family
D6270_RS04460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D6270_RS04470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D6270_RS04475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D6270_RS04480	COG0006	proline dipeptidase activity
D6270_RS04490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D6270_RS04495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D6270_RS04500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D6270_RS04505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D6270_RS04520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D6270_RS04525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D6270_RS04545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D6270_RS04575	COG0124	histidyl-tRNA synthetase
D6270_RS04590	COG1196	nuclear chromosome segregation
D6270_RS04595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D6270_RS04600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D6270_RS04605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6270_RS04610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6270_RS04625	COG0632	four-way junction helicase activity
D6270_RS04630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D6270_RS04635	COG0217	transcriptional regulatory protein
D6270_RS04640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D6270_RS04645	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D6270_RS04655	COG0438	transferase activity, transferring glycosyl groups
D6270_RS04660	COG1560	Kdo2-lipid A biosynthetic process
D6270_RS04665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D6270_RS04690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D6270_RS04705	COG5002	protein histidine kinase activity
D6270_RS04705	COG2176	DNA-directed DNA polymerase activity
D6270_RS04750	COG0456	acetyltransferase
D6270_RS04750	COG0454	-acetyltransferase
D6270_RS04820	COG1648	precorrin-2 dehydrogenase activity
D6270_RS04820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D6270_RS04825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D6270_RS04840	COG1464	Belongs to the NlpA lipoprotein family
D6270_RS04885	COG0477	Major facilitator Superfamily
D6270_RS04895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D6270_RS04900	COG3973	AAA domain
D6270_RS04910	COG0165	Argininosuccinate lyase
D6270_RS04915	COG0137	argininosuccinate synthase activity
D6270_RS04925	COG1438	arginine binding
D6270_RS04930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D6270_RS04935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D6270_RS04940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D6270_RS04945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D6270_RS04950	COG4977	sequence-specific DNA binding
D6270_RS04990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6270_RS05005	COG0697	spore germination
D6270_RS05010	COG1649	PFAM Uncharacterised BCR, COG1649
D6270_RS05070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6270_RS05070	COG0072	phenylalanine-tRNA ligase activity
D6270_RS05075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D6270_RS05080	COG5002	protein histidine kinase activity
D6270_RS05085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6270_RS05090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D6270_RS05095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D6270_RS05100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D6270_RS05115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D6270_RS05165	COG0517	IMP dehydrogenase activity
D6270_RS05165	COG4175	Glycine betaine
D6270_RS05170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6270_RS05215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D6270_RS05220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D6270_RS05260	COG0805	protein transport
D6270_RS05265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D6270_RS05285	COG2378	regulation of single-species biofilm formation
D6270_RS05295	COG0545	Peptidyl-prolyl cis-trans isomerase
D6270_RS05300	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D6270_RS05310	COG1609	Transcriptional regulator
D6270_RS05315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D6270_RS05320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D6270_RS05335	COG4122	O-methyltransferase activity
D6270_RS05340	COG1222	aaa ATPase
D6270_RS05365	COG0517	IMP dehydrogenase activity
D6270_RS05365	COG1994	Peptidase M50
D6270_RS05375	COG2197	response regulator
D6270_RS05380	COG4166	transmembrane transport
D6270_RS05390	COG0646	methionine synthase
D6270_RS05390	COG1410	methionine synthase
D6270_RS05395	COG1414	Transcriptional regulator
D6270_RS05400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D6270_RS05405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D6270_RS05410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D6270_RS05415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS05430	COG0215	cysteine-tRNA ligase activity
D6270_RS05450	COG0598	Magnesium transport protein CorA
D6270_RS05460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS05465	COG0667	Aldo Keto reductase
D6270_RS05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6270_RS05505	COG0564	pseudouridine synthase activity
D6270_RS05520	COG2186	Transcriptional regulator
D6270_RS05525	COG3265	gluconokinase activity
D6270_RS05550	COG3573	Dehydrogenase
D6270_RS05555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D6270_RS05560	COG2149	membrane
D6270_RS05575	COG4948	Mandelate Racemase Muconate Lactonizing
D6270_RS05590	COG4935	Belongs to the peptidase S8 family
D6270_RS05590	COG2234	aminopeptidase activity
D6270_RS05610	COG3876	Protein conserved in bacteria
D6270_RS05650	COG1960	acyl-CoA dehydrogenase activity
D6270_RS05665	COG2326	polyphosphate kinase activity
D6270_RS05680	COG3842	ATPase activity
D6270_RS05690	COG2851	Citrate transporter
D6270_RS05695	COG0243	molybdopterin cofactor binding
D6270_RS05700	COG1309	transcriptional regulator
D6270_RS05705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D6270_RS05710	COG2188	Transcriptional regulator
D6270_RS05720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D6270_RS05730	COG2755	lipolytic protein G-D-S-L family
D6270_RS05740	COG1725	Transcriptional regulator
D6270_RS05755	COG2226	methyltransferase
D6270_RS05775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D6270_RS05780	COG0587	DNA-directed DNA polymerase activity
D6270_RS05820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS05825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS05830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6270_RS05835	COG1126	abc transporter atp-binding protein
D6270_RS05850	COG0765	amino acid transport
D6270_RS05855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6270_RS05865	COG1799	cell septum assembly
D6270_RS05870	COG1960	acyl-CoA dehydrogenase activity
D6270_RS05875	COG0477	Major facilitator Superfamily
D6270_RS05900	COG0438	transferase activity, transferring glycosyl groups
D6270_RS05915	COG1160	GTP binding
D6270_RS05925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D6270_RS05960	COG3541	Predicted nucleotidyltransferase
D6270_RS05970	COG0494	nUDIX hydrolase
D6270_RS05985	COG1187	pseudouridine synthase activity
D6270_RS05990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D6270_RS05995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D6270_RS06010	COG0686	Belongs to the AlaDH PNT family
D6270_RS06020	COG0494	nUDIX hydrolase
D6270_RS06025	COG0504	CTP synthase activity
D6270_RS06030	COG3387	PFAM Glycoside hydrolase 15-related
D6270_RS06045	COG0297	glycogen (starch) synthase activity
D6270_RS06055	COG0497	DNA recombination
D6270_RS06060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D6270_RS06080	COG1120	ATPase activity
D6270_RS06085	COG0647	UMP catabolic process
D6270_RS06125	COG2094	Belongs to the DNA glycosylase MPG family
D6270_RS06135	COG1881	PFAM PEBP family protein
D6270_RS06160	COG1119	ATPase activity
D6270_RS06175	COG2197	response regulator
D6270_RS06180	COG4585	Histidine kinase
D6270_RS06190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D6270_RS06200	COG1131	(ABC) transporter
D6270_RS06200	COG1716	ATPase activity
D6270_RS06200	COG0842	Transport permease protein
D6270_RS06205	COG0560	Phosphoserine phosphatase
D6270_RS06205	COG3830	Belongs to the UPF0237 family
D6270_RS06230	COG2186	Transcriptional regulator
D6270_RS06240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D6270_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS06260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D6270_RS06265	COG2261	transglycosylase associated protein
D6270_RS06280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D6270_RS06285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6270_RS06305	COG1063	alcohol dehydrogenase
D6270_RS06340	COG3387	PFAM Glycoside hydrolase 15-related
D6270_RS06380	COG1024	Enoyl-CoA hydratase
D6270_RS06390	COG0488	(ABC) transporter
D6270_RS06415	COG0235	Class ii aldolase
D6270_RS06430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D6270_RS06450	COG1797	cobyrinic acid a,c-diamide synthase activity
D6270_RS06475	COG1104	cysteine desulfurase activity
D6270_RS06490	COG1917	Cupin 2, conserved barrel domain protein
D6270_RS06505	COG1902	pentaerythritol trinitrate reductase activity
D6270_RS06510	COG1846	Transcriptional regulator
D6270_RS06535	COG1414	Transcriptional regulator
D6270_RS06545	COG0768	penicillin binding
D6270_RS06585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6270_RS06590	COG2171	N-acyltransferase activity
D6270_RS06595	COG3226	Transcriptional regulator
D6270_RS06600	COG2076	Multidrug Resistance protein
D6270_RS06615	COG2151	metal-sulfur cluster biosynthetic enzyme
D6270_RS06620	COG0822	iron-sulfur transferase activity
D6270_RS06625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D6270_RS06630	COG0396	ATPase activity
D6270_RS06640	COG0719	Fe-S assembly protein
D6270_RS06655	COG1131	(ABC) transporter
D6270_RS06675	COG0109	protoheme IX farnesyltransferase activity
D6270_RS06685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D6270_RS06700	COG0363	glucosamine-6-phosphate deaminase activity
D6270_RS06710	COG4195	phage-related replication protein
D6270_RS06725	COG0166	Belongs to the GPI family
D6270_RS06735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D6270_RS06740	COG0149	triose-phosphate isomerase activity
D6270_RS06745	COG0126	phosphoglycerate kinase activity
D6270_RS06750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D6270_RS06755	COG1481	regulation of sporulation
D6270_RS06760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D6270_RS06765	COG1660	Displays ATPase and GTPase activities
D6270_RS06770	COG0322	excinuclease ABC activity
D6270_RS06795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6270_RS06825	COG0556	nucleotide-excision repair
D6270_RS06835	COG0584	glycerophosphoryl diester phosphodiesterase
D6270_RS06840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D6270_RS06845	COG2814	Major facilitator Superfamily
D6270_RS06855	COG2313	pseudouridylate synthase activity
D6270_RS06875	COG0436	Aminotransferase
D6270_RS06895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D6270_RS06920	COG0237	dephospho-CoA kinase activity
D6270_RS06940	COG2226	methyltransferase
D6270_RS06945	COG1643	Atp-dependent helicase
D6270_RS06980	COG2050	protein possibly involved in aromatic compounds catabolism
D6270_RS07035	COG0737	Belongs to the 5'-nucleotidase family
D6270_RS07060	COG2824	Alkylphosphonate utilization operon protein PhnA
D6270_RS07080	COG1605	Chorismate mutase
D6270_RS07080	COG0287	Prephenate dehydrogenase
D6270_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS07125	COG1024	Enoyl-CoA hydratase
D6270_RS07150	COG1278	Cold shock
D6270_RS07155	COG0183	Belongs to the thiolase family
D6270_RS07160	COG1309	transcriptional regulator
D6270_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS07170	COG1960	acyl-CoA dehydrogenase activity
D6270_RS07175	COG1960	acyl-CoA dehydrogenase activity
D6270_RS07195	COG0705	Rhomboid family
D6270_RS07205	COG0067	glutamate synthase
D6270_RS07205	COG0070	glutamate synthase
D6270_RS07205	COG0069	glutamate synthase activity
D6270_RS07240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D6270_RS07250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D6270_RS07260	COG0159	tryptophan synthase activity
D6270_RS07265	COG0133	tryptophan synthase activity
D6270_RS07275	COG0134	indole-3-glycerol-phosphate synthase activity
D6270_RS07295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D6270_RS07300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D6270_RS07310	COG2508	Transcriptional regulator
D6270_RS07325	COG0107	imidazoleglycerol-phosphate synthase activity
D6270_RS07330	COG0251	oxidation-reduction process
D6270_RS07335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D6270_RS07340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D6270_RS07345	COG0131	Imidazoleglycerol-phosphate dehydratase
D6270_RS07350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D6270_RS07355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D6270_RS07395	COG1432	Conserved Protein
D6270_RS07405	COG0587	DNA-directed DNA polymerase activity
D6270_RS07455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D6270_RS07465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D6270_RS07470	COG3599	regulation of cell shape
D6270_RS07480	COG1799	cell septum assembly
D6270_RS07485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D6270_RS07510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D6270_RS07520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D6270_RS07525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D6270_RS07535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D6270_RS07540	COG0768	penicillin binding
D6270_RS07550	COG0275	rRNA processing
D6270_RS07560	COG0714	Associated with various cellular activities
D6270_RS07580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D6270_RS07590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D6270_RS07610	COG1233	COG1233 Phytoene dehydrogenase and related
D6270_RS07625	COG0352	thiamine-phosphate diphosphorylase activity
D6270_RS07645	COG2022	thiamine diphosphate biosynthetic process
D6270_RS07645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6270_RS07655	COG2022	thiamine diphosphate biosynthetic process
D6270_RS07660	COG0515	serine threonine protein kinase
D6270_RS07660	COG2815	serine threonine protein kinase
D6270_RS07665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D6270_RS07670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D6270_RS07675	COG2193	ferroxidase activity
D6270_RS07685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D6270_RS07700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D6270_RS07710	COG4585	Histidine kinase
D6270_RS07735	COG1940	carbohydrate kinase activity
D6270_RS07745	COG0003	Pfam Anion-transporting ATPase
D6270_RS07765	COG0438	transferase activity, transferring glycosyl groups
D6270_RS07810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D6270_RS07815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6270_RS07820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D6270_RS07825	COG0723	plastoquinol--plastocyanin reductase activity
D6270_RS07830	COG2010	Cytochrome c
D6270_RS07835	COG1845	cytochrome c oxidase, subunit III
D6270_RS07845	COG1376	ErfK ybiS ycfS ynhG family protein
D6270_RS07855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D6270_RS07860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D6270_RS07865	COG1104	cysteine desulfurase activity
D6270_RS07870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6270_RS07890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D6270_RS07900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D6270_RS07905	COG2197	response regulator
D6270_RS07910	COG4585	Histidine kinase
D6270_RS07935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6270_RS07950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D6270_RS07955	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D6270_RS07955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D6270_RS07970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D6270_RS07975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D6270_RS07980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D6270_RS07985	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6270_RS07995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D6270_RS08015	COG1090	epimerase
D6270_RS08030	COG0321	lipoyl(octanoyl) transferase activity
D6270_RS08035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D6270_RS08065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6270_RS08105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6270_RS08130	COG0745	RESPONSE REGULATOR receiver
D6270_RS08140	COG4585	Histidine kinase
D6270_RS08145	COG2197	response regulator
D6270_RS08165	COG2226	methyltransferase
D6270_RS08210	COG0366	Alpha amylase catalytic
D6270_RS08215	COG3833	ABC-type maltose transport systems, permease component
D6270_RS08230	COG1609	Transcriptional regulator
D6270_RS08260	COG2890	protein-(glutamine-N5) methyltransferase activity
D6270_RS08295	COG0174	glutamine synthetase
D6270_RS08320	COG2132	Multicopper oxidase
D6270_RS08325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D6270_RS08325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D6270_RS08330	COG2814	Major facilitator Superfamily
D6270_RS08345	COG0477	Major facilitator Superfamily
D6270_RS08350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D6270_RS08370	COG1994	Peptidase M50
D6270_RS08440	COG1120	ATPase activity
D6270_RS08460	COG1834	amidinotransferase
D6270_RS08475	COG2814	Major facilitator Superfamily
D6270_RS08485	COG3540	Alkaline phosphatase
D6270_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS08500	COG0384	phenazine biosynthesis protein PhzF
D6270_RS08535	COG3022	response to hydroperoxide
D6270_RS08540	COG0800	Aldolase
D6270_RS08555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D6270_RS08560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6270_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS08580	COG2030	dehydratase
D6270_RS08590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D6270_RS08595	COG0183	Belongs to the thiolase family
D6270_RS08625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS08660	COG1309	transcriptional regulator
D6270_RS08735	COG3845	ABC transporter
D6270_RS08745	COG0183	Belongs to the thiolase family
D6270_RS08750	COG2124	cytochrome p450
D6270_RS08800	COG2259	Doxx family
D6270_RS08880	COG1358	cellular component organization or biogenesis
D6270_RS08930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D6270_RS08940	COG0477	Major facilitator Superfamily
D6270_RS08945	COG1309	transcriptional regulator
D6270_RS08960	COG4585	Histidine kinase
D6270_RS08965	COG2197	response regulator
D6270_RS08980	COG0667	Aldo Keto reductase
D6270_RS08985	COG0789	Transcriptional regulator
D6270_RS09020	COG1741	Belongs to the pirin family
D6270_RS09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6270_RS09040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D6270_RS09045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6270_RS09080	COG1764	response to oxidative stress
D6270_RS09085	COG2130	NADP-dependent
D6270_RS09120	COG1522	sequence-specific DNA binding
D6270_RS09150	COG1131	(ABC) transporter
D6270_RS09160	COG1595	DNA-templated transcription, initiation
D6270_RS09165	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS09170	COG0825	malonyl-CoA metabolic process
D6270_RS09170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D6270_RS09200	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS09230	COG1819	glycosyl
D6270_RS09240	COG1819	glycosyl
D6270_RS09255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6270_RS09280	COG0667	Aldo Keto reductase
D6270_RS09335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6270_RS09350	COG0825	malonyl-CoA metabolic process
D6270_RS09350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D6270_RS09375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D6270_RS09380	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D6270_RS09405	COG1070	Carbohydrate kinase
D6270_RS09425	COG0358	DNA primase activity
D6270_RS09430	COG2226	methyltransferase
D6270_RS09455	COG2949	membrane
D6270_RS09520	COG0574	Belongs to the PEP-utilizing enzyme family
D6270_RS09520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D6270_RS09530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D6270_RS09550	COG2188	Transcriptional regulator
D6270_RS09565	COG0110	maltose O-acetyltransferase activity
D6270_RS09590	COG0477	Major facilitator Superfamily
D6270_RS09600	COG3693	PFAM glycoside hydrolase, family 10
D6270_RS09630	COG1473	amidohydrolase
D6270_RS09635	COG0477	Major facilitator Superfamily
D6270_RS09650	COG0745	RESPONSE REGULATOR receiver
D6270_RS09655	COG0642	Histidine kinase
D6270_RS09655	COG3850	Histidine kinase
D6270_RS09675	COG3647	Membrane
D6270_RS09775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D6270_RS09785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D6270_RS09800	COG0423	glycine-tRNA ligase activity
D6270_RS09810	COG1121	(ABC) transporter
D6270_RS09815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D6270_RS09825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D6270_RS09830	COG1381	Involved in DNA repair and RecF pathway recombination
D6270_RS09840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D6270_RS09855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D6270_RS09865	COG2315	Protein conserved in bacteria
D6270_RS09875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D6270_RS09885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6270_RS09895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D6270_RS09900	COG1234	tRNA 3'-trailer cleavage
D6270_RS09905	COG0537	adenosine 5'-monophosphoramidase activity
D6270_RS09920	COG0484	heat shock protein binding
D6270_RS09925	COG1420	regulation of RNA biosynthetic process
D6270_RS09965	COG1022	Amp-dependent synthetase and ligase
D6270_RS09970	COG0481	GTPase activity
D6270_RS09980	COG0268	Binds directly to 16S ribosomal RNA
D6270_RS09995	COG2333	competence protein COMEC
D6270_RS09995	COG0658	competence protein
D6270_RS10000	COG1555	photosystem II stabilization
D6270_RS10005	COG1307	EDD domain protein, DegV family
D6270_RS10015	COG0495	leucyl-tRNA aminoacylation
D6270_RS10045	COG0588	phosphoglycerate mutase activity
D6270_RS10050	COG0799	negative regulation of ribosome biogenesis
D6270_RS10060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D6270_RS10065	COG0501	Belongs to the peptidase M48B family
D6270_RS10080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D6270_RS10095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6270_RS10115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D6270_RS10120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D6270_RS10125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D6270_RS10185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D6270_RS10200	COG0673	inositol 2-dehydrogenase activity
D6270_RS10205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D6270_RS10235	COG0772	Belongs to the SEDS family
D6270_RS10240	COG0768	penicillin binding
D6270_RS10255	COG1077	Cell shape determining protein MreB Mrl
D6270_RS10260	COG0105	UTP biosynthetic process
D6270_RS10270	COG0285	dihydrofolate synthase activity
D6270_RS10275	COG0525	valine-tRNA ligase activity
D6270_RS10285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D6270_RS10290	COG0740	serine-type endopeptidase activity
D6270_RS10295	COG0740	serine-type endopeptidase activity
D6270_RS10300	COG0544	peptidyl-prolyl cis-trans isomerase activity
D6270_RS10320	COG3594	Acyltransferase
D6270_RS10330	COG0475	glutathione-regulated potassium exporter activity
D6270_RS10340	COG4552	Acetyltransferase involved in intracellular survival and related
D6270_RS10355	COG1113	amino acid transport
D6270_RS10365	COG1268	BioY protein
D6270_RS10370	COG1113	amino acid transport
D6270_RS10375	COG1113	amino acid transport
D6270_RS10385	COG0584	glycerophosphoryl diester phosphodiesterase
D6270_RS10390	COG0783	Belongs to the Dps family
D6270_RS10395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D6270_RS10400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D6270_RS10405	COG0640	Transcriptional regulator
D6270_RS10415	COG0110	maltose O-acetyltransferase activity
D6270_RS10425	COG2211	Major facilitator Superfamily
D6270_RS10435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D6270_RS10505	COG3291	Pkd domain containing protein
D6270_RS10505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6270_RS10515	COG0668	transmembrane transport
D6270_RS10520	COG1940	carbohydrate kinase activity
D6270_RS10530	COG1175	transmembrane transport
D6270_RS10535	COG0395	ABC-type sugar transport system, permease component
D6270_RS10540	COG1486	melibiose metabolic process
D6270_RS10555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6270_RS10585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D6270_RS10590	COG2346	COG2346, Truncated hemoglobins
D6270_RS10615	COG0629	single-stranded DNA binding
D6270_RS10620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D6270_RS10665	COG1131	(ABC) transporter
D6270_RS10680	COG3962	Belongs to the TPP enzyme family
D6270_RS10685	COG3718	enzyme involved in inositol metabolism
D6270_RS10700	COG1082	Xylose isomerase domain protein TIM barrel
D6270_RS10720	COG2409	Drug exporters of the RND superfamily
D6270_RS10745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D6270_RS10785	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D6270_RS10810	COG0673	inositol 2-dehydrogenase activity
D6270_RS10815	COG1609	Transcriptional regulator
D6270_RS10845	COG0515	serine threonine protein kinase
D6270_RS10875	COG1404	Belongs to the peptidase S8 family
D6270_RS10895	COG1472	Belongs to the glycosyl hydrolase 3 family
D6270_RS10925	COG0028	Belongs to the TPP enzyme family
D6270_RS10935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6270_RS10960	COG1674	ftsk spoiiie
D6270_RS11020	COG1946	Acyl-CoA thioesterase
D6270_RS11040	COG2755	lipolytic protein G-D-S-L family
D6270_RS11040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D6270_RS11060	COG1309	transcriptional regulator
D6270_RS11065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6270_RS11080	COG1960	acyl-CoA dehydrogenase activity
D6270_RS11090	COG1733	regulation of RNA biosynthetic process
D6270_RS11110	COG0076	glutamate decarboxylase activity
D6270_RS11115	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D6270_RS11140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D6270_RS11145	COG0589	response to stress
D6270_RS11150	COG4977	sequence-specific DNA binding
D6270_RS11170	COG2770	Histidine kinase
D6270_RS11170	COG2208	phosphoserine phosphatase activity
D6270_RS11205	COG0395	ABC-type sugar transport system, permease component
D6270_RS11220	COG2985	domain, Protein
D6270_RS11225	COG2985	domain, Protein
D6270_RS11245	COG0745	RESPONSE REGULATOR receiver
D6270_RS11270	COG0588	phosphoglycerate mutase activity
D6270_RS11320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS11335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6270_RS11340	COG0765	amino acid transport
D6270_RS11345	COG0765	amino acid transport
D6270_RS11350	COG1126	abc transporter atp-binding protein
D6270_RS11365	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS11370	COG3397	chitin binding
D6270_RS11445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6270_RS11455	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D6270_RS11460	COG2376	Dihydroxyacetone kinase
D6270_RS11465	COG2376	Dihydroxyacetone kinase
D6270_RS11470	COG0546	phosphoglycolate phosphatase activity
D6270_RS11475	COG2188	Transcriptional regulator
D6270_RS11490	COG0673	inositol 2-dehydrogenase activity
D6270_RS11495	COG4702	Belongs to the UPF0303 family
D6270_RS11505	COG0706	membrane insertase activity
D6270_RS11505	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
D6270_RS11515	COG3764	Sortase (surface protein transpeptidase)
D6270_RS11565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6270_RS11580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D6270_RS11620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6270_RS11645	COG0477	Major facilitator Superfamily
D6270_RS11660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D6270_RS11670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D6270_RS11675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6270_RS11680	COG1263	PTS System
D6270_RS11685	COG1263	PTS System
D6270_RS11690	COG1234	tRNA 3'-trailer cleavage
D6270_RS11720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS11735	COG1113	amino acid transport
D6270_RS11745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D6270_RS11755	COG1335	isochorismatase
D6270_RS11790	COG0277	FAD linked oxidase domain protein
D6270_RS11800	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D6270_RS11810	COG1174	glycine betaine transport
D6270_RS11820	COG1174	glycine betaine transport
D6270_RS11825	COG1732	Glycine betaine
D6270_RS11830	COG3480	Lon protease (S16) C-terminal proteolytic domain
D6270_RS11840	COG1061	Type III restriction enzyme res subunit
D6270_RS11880	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6270_RS11885	COG0395	ABC-type sugar transport system, permease component
D6270_RS11890	COG1175	transmembrane transport
D6270_RS11905	COG1678	Uncharacterized ACR, COG1678
D6270_RS11910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D6270_RS11925	COG0776	regulation of translation
D6270_RS11935	COG3973	AAA domain
D6270_RS11935	COG3973	AAA domain
D6270_RS11985	COG0583	DNA-binding transcription factor activity
D6270_RS12000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D6270_RS12005	COG0793	Belongs to the peptidase S41A family
D6270_RS12010	COG2177	Part of the ABC transporter FtsEX involved in
D6270_RS12015	COG2884	Cell division ATP-binding protein ftsE
D6270_RS12030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D6270_RS12040	COG0515	serine threonine protein kinase
D6270_RS12050	COG3547	Transposase (IS116 IS110 IS902 family)
D6270_RS12055	COG1653	transport
D6270_RS12060	COG1175	transmembrane transport
D6270_RS12070	COG0463	Glycosyl transferase, family 2
D6270_RS12070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6270_RS12075	COG0438	transferase activity, transferring glycosyl groups
D6270_RS12080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6270_RS12085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6270_RS12095	COG1073	alpha beta
D6270_RS12095	COG2226	methyltransferase
D6270_RS12100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6270_RS12105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D6270_RS12115	COG1309	transcriptional regulator
D6270_RS12125	COG1134	teichoic acid transport
D6270_RS12155	COG0653	protein targeting
D6270_RS12175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D6270_RS12185	COG0823	Involved in the tonB-independent uptake of proteins
D6270_RS12190	COG5002	protein histidine kinase activity
D6270_RS12190	COG5000	phosphorelay sensor kinase activity
D6270_RS12195	COG0745	RESPONSE REGULATOR receiver
D6270_RS12200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D6270_RS12220	COG0714	Associated with various cellular activities
D6270_RS12265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D6270_RS12285	COG2835	tetraacyldisaccharide 4'-kinase activity
D6270_RS12335	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D6270_RS12340	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D6270_RS12340	COG0778	Nitroreductase
D6270_RS12350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D6270_RS12365	COG1316	TRANSCRIPTIONal
D6270_RS12370	COG1316	TRANSCRIPTIONal
D6270_RS12385	COG1316	TRANSCRIPTIONal
D6270_RS12395	COG1316	TRANSCRIPTIONal
D6270_RS12455	COG2205	protein histidine kinase activity
D6270_RS12460	COG0745	RESPONSE REGULATOR receiver
D6270_RS12465	COG3104	oligopeptide transport
D6270_RS12495	COG1366	Belongs to the anti-sigma-factor antagonist family
D6270_RS12505	COG1228	amidohydrolase
D6270_RS12515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6270_RS12520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D6270_RS12565	COG2755	lipolytic protein G-D-S-L family
D6270_RS12570	COG0183	Belongs to the thiolase family
D6270_RS12595	COG0577	efflux transmembrane transporter activity
D6270_RS12595	COG1136	(ABC) transporter
D6270_RS12600	COG0577	efflux transmembrane transporter activity
D6270_RS12600	COG1136	(ABC) transporter
D6270_RS12605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D6270_RS12610	COG1252	NADH dehydrogenase
D6270_RS12635	COG0148	phosphopyruvate hydratase activity
D6270_RS12650	COG2124	cytochrome p450
D6270_RS12755	COG1994	Peptidase M50
D6270_RS12785	COG3629	intracellular signal transduction
D6270_RS12785	COG3903	Transcriptional regulator
D6270_RS12795	COG0577	efflux transmembrane transporter activity
D6270_RS12800	COG1136	(ABC) transporter
D6270_RS12810	COG2814	Major facilitator Superfamily
D6270_RS12860	COG2124	cytochrome p450
D6270_RS12890	COG4585	Histidine kinase
D6270_RS12900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D6270_RS12905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D6270_RS12910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D6270_RS12915	COG0193	aminoacyl-tRNA hydrolase activity
D6270_RS12925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D6270_RS12945	COG4106	trans-aconitate 2-methyltransferase activity
D6270_RS12950	COG1846	Transcriptional regulator
D6270_RS12955	COG2197	response regulator
D6270_RS12965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D6270_RS12980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6270_RS13005	COG0488	(ABC) transporter
D6270_RS13025	COG2813	Specifically methylates the guanine in position
D6270_RS13030	COG2318	DinB family
D6270_RS13035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D6270_RS13040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D6270_RS13050	COG0084	hydrolase, TatD family'
D6270_RS13075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6270_RS13110	COG0442	prolyl-tRNA aminoacylation
D6270_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS13145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D6270_RS13150	COG1122	ATPase activity
D6270_RS13160	COG0310	cobalt ion transport
D6270_RS13190	COG2409	Drug exporters of the RND superfamily
D6270_RS13200	COG0793	Belongs to the peptidase S41A family
D6270_RS13200	COG4946	Tricorn protease homolog
D6270_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS13220	COG2072	flavoprotein involved in K transport
D6270_RS13230	COG0708	Exodeoxyribonuclease III
D6270_RS13240	COG2340	Cysteine-rich secretory protein family
D6270_RS13270	COG0521	Mo-molybdopterin cofactor biosynthetic process
D6270_RS13275	COG0315	cyclic pyranopterin monophosphate synthase activity
D6270_RS13285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D6270_RS13290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D6270_RS13315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D6270_RS13325	COG1970	mechanosensitive ion channel activity
D6270_RS13350	COG0243	molybdopterin cofactor binding
D6270_RS13360	COG3191	aminopeptidase activity
D6270_RS13370	COG0477	Major facilitator Superfamily
D6270_RS13390	COG3384	dioxygenase
D6270_RS13395	COG1846	Transcriptional regulator
D6270_RS13420	COG2197	response regulator
D6270_RS13435	COG1834	amidinotransferase
D6270_RS13520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS13535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS13540	COG1063	alcohol dehydrogenase
D6270_RS13545	COG5285	phytanoyl-CoA dioxygenase
D6270_RS13590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D6270_RS13595	COG0514	ATP-dependent DNA helicase (RecQ)
D6270_RS13650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D6270_RS13655	COG0602	queuosine metabolic process
D6270_RS13660	COG0720	synthase
D6270_RS13665	COG1469	GTP cyclohydrolase I activity
D6270_RS13695	COG3547	Transposase (IS116 IS110 IS902 family)
D6270_RS13755	COG1686	Belongs to the peptidase S11 family
D6270_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS13805	COG3655	Transcriptional regulator
D6270_RS13835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D6270_RS13850	COG0768	penicillin binding
D6270_RS13925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6270_RS13960	COG0183	Belongs to the thiolase family
D6270_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS13980	COG1309	transcriptional regulator
D6270_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS14025	COG1301	dicarboxylic acid transport
D6270_RS14040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D6270_RS14050	COG0163	prenyltransferase activity
D6270_RS14060	COG0109	protoheme IX farnesyltransferase activity
D6270_RS14065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D6270_RS14075	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS14080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D6270_RS14085	COG1333	cytochrome c biogenesis protein
D6270_RS14090	COG0785	Cytochrome C biogenesis protein
D6270_RS14105	COG2382	esterase
D6270_RS14110	COG0406	alpha-ribazole phosphatase activity
D6270_RS14115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D6270_RS14160	COG1690	Belongs to the RtcB family
D6270_RS14180	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D6270_RS14185	COG0018	arginyl-trna synthetase
D6270_RS14195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D6270_RS14225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D6270_RS14255	COG0113	porphobilinogen synthase activity
D6270_RS14260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D6270_RS14260	COG1648	precorrin-2 dehydrogenase activity
D6270_RS14265	COG0181	hydroxymethylbilane synthase activity
D6270_RS14270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D6270_RS14275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D6270_RS14325	COG0123	including yeast histone deacetylase and acetoin utilization protein
D6270_RS14330	COG2223	nitrite transmembrane transporter activity
D6270_RS14335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D6270_RS14360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D6270_RS14370	COG0842	Transport permease protein
D6270_RS14370	COG1129	ABC transporter
D6270_RS14380	COG4991	sh3 domain protein
D6270_RS14390	COG0129	dihydroxy-acid dehydratase activity
D6270_RS14400	COG1082	Xylose isomerase domain protein TIM barrel
D6270_RS14405	COG0248	Ppx GppA phosphatase
D6270_RS14425	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D6270_RS14440	COG1194	a g-specific adenine glycosylase
D6270_RS14445	COG1595	DNA-templated transcription, initiation
D6270_RS14455	COG0745	RESPONSE REGULATOR receiver
D6270_RS14460	COG2205	protein histidine kinase activity
D6270_RS14465	COG0739	heme binding
D6270_RS14500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D6270_RS14520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D6270_RS14530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D6270_RS14535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D6270_RS14560	COG1660	Displays ATPase and GTPase activities
D6270_RS14565	COG2197	response regulator
D6270_RS14580	COG0649	NAD binding
D6270_RS14595	COG1174	glycine betaine transport
D6270_RS14600	COG1174	glycine betaine transport
D6270_RS14615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D6270_RS14615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D6270_RS14635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D6270_RS14650	COG0302	gtp cyclohydrolase
D6270_RS14665	COG0037	tRNA processing
D6270_RS14675	COG2027	D-alanyl-D-alanine carboxypeptidase
D6270_RS14680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D6270_RS14690	COG0586	Pfam SNARE associated Golgi protein
D6270_RS14695	COG0393	Putative heavy-metal-binding
D6270_RS14705	COG0655	NAD(P)H dehydrogenase (quinone) activity
D6270_RS14710	COG0076	glutamate decarboxylase activity
D6270_RS14725	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS14760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6270_RS14760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D6270_RS14780	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D6270_RS14795	COG2267	carboxylic ester hydrolase activity
D6270_RS14800	COG0604	alcohol dehydrogenase
D6270_RS14800	COG3321	synthase
D6270_RS14805	COG3321	synthase
D6270_RS14805	COG0604	alcohol dehydrogenase
D6270_RS14810	COG0604	alcohol dehydrogenase
D6270_RS14810	COG3321	synthase
D6270_RS14820	COG3321	synthase
D6270_RS14820	COG0604	alcohol dehydrogenase
D6270_RS14840	COG0477	Major facilitator Superfamily
D6270_RS14855	COG0604	alcohol dehydrogenase
D6270_RS14855	COG3321	synthase
D6270_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS14885	COG1141	Ferredoxin
D6270_RS14890	COG2124	cytochrome p450
D6270_RS15005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D6270_RS15020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS15030	COG1132	(ABC) transporter
D6270_RS15040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D6270_RS15045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D6270_RS15050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D6270_RS15050	COG1754	DNA topoisomerase type I activity
D6270_RS15065	COG2890	protein-(glutamine-N5) methyltransferase activity
D6270_RS15075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D6270_RS15080	COG2172	sigma factor antagonist activity
D6270_RS15085	COG1366	Belongs to the anti-sigma-factor antagonist family
D6270_RS15090	COG1205	dead DEAH box helicase
D6270_RS15090	COG1111	helicase
D6270_RS15095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6270_RS15165	COG0288	reversible hydration of carbon dioxide
D6270_RS15170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6270_RS15175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D6270_RS15185	COG2267	carboxylic ester hydrolase activity
D6270_RS15240	COG0003	Pfam Anion-transporting ATPase
D6270_RS15255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D6270_RS15260	COG1610	YqeY-like protein
D6270_RS15265	COG1408	metallophosphoesterase
D6270_RS15370	COG2755	lipolytic protein G-D-S-L family
D6270_RS15380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D6270_RS15400	COG1595	DNA-templated transcription, initiation
D6270_RS15435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D6270_RS15440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D6270_RS15455	COG1802	Transcriptional regulator
D6270_RS15460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D6270_RS15470	COG0738	Major facilitator superfamily
D6270_RS15495	COG3226	Transcriptional regulator
D6270_RS15510	COG0592	DNA-directed DNA polymerase activity
D6270_RS15525	COG0142	geranyltranstransferase activity
D6270_RS15535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D6270_RS15540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D6270_RS15555	COG2197	response regulator
D6270_RS15575	COG3844	kynureninase activity
D6270_RS15590	COG0477	Major facilitator Superfamily
D6270_RS15595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D6270_RS15600	COG0191	fructose-bisphosphate aldolase activity
D6270_RS15605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D6270_RS15620	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D6270_RS15645	COG0542	response to heat
D6270_RS15675	COG0789	Transcriptional regulator
D6270_RS15680	COG0484	heat shock protein binding
D6270_RS15685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D6270_RS15690	COG0443	Heat shock 70 kDa protein
D6270_RS15700	COG2181	nitrate reductase activity
D6270_RS15700	COG0247	lactate metabolic process
D6270_RS15720	COG0717	Belongs to the dCTP deaminase family
D6270_RS15795	COG1533	DNA photolyase activity
D6270_RS15810	COG2130	NADP-dependent
D6270_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS15865	COG0367	asparagine synthase
D6270_RS15905	COG2205	protein histidine kinase activity
D6270_RS15910	COG0745	RESPONSE REGULATOR receiver
D6270_RS15945	COG0745	RESPONSE REGULATOR receiver
D6270_RS15955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D6270_RS15965	COG1181	Belongs to the D-alanine--D-alanine ligase family
D6270_RS15980	COG0519	Catalyzes the synthesis of GMP from XMP
D6270_RS15980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D6270_RS16015	COG0667	Aldo Keto reductase
D6270_RS16025	COG1609	Transcriptional regulator
D6270_RS16070	COG2124	cytochrome p450
D6270_RS16075	COG2124	cytochrome p450
D6270_RS16095	COG3585	molybdate ion transport
D6270_RS16140	COG0475	glutathione-regulated potassium exporter activity
D6270_RS16145	COG3594	Acyltransferase
D6270_RS16155	COG0513	Belongs to the DEAD box helicase family
D6270_RS16160	COG1278	Cold shock
D6270_RS16185	COG5002	protein histidine kinase activity
D6270_RS16250	COG2268	Band 7 protein
D6270_RS16285	COG0490	domain, Protein
D6270_RS16290	COG0475	glutathione-regulated potassium exporter activity
D6270_RS16325	COG0180	Tryptophanyl-tRNA synthetase
D6270_RS16335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS16365	COG0431	NADPH-dependent FMN reductase
D6270_RS16390	COG2304	oxidoreductase activity
D6270_RS16395	COG2205	protein histidine kinase activity
D6270_RS16400	COG0745	RESPONSE REGULATOR receiver
D6270_RS16405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D6270_RS16440	COG1960	acyl-CoA dehydrogenase activity
D6270_RS16450	COG1362	aminopeptidase activity
D6270_RS16490	COG1802	Transcriptional regulator
D6270_RS16500	COG0508	dehydrogenase complex catalyzes the overall conversion of
D6270_RS16505	COG0022	dehydrogenase e1 component
D6270_RS16530	COG0515	serine threonine protein kinase
D6270_RS16535	COG0515	serine threonine protein kinase
D6270_RS16550	COG4591	ABC-type transport system involved in lipoprotein release permease component
D6270_RS16550	COG1136	(ABC) transporter
D6270_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS16565	COG3321	synthase
D6270_RS16565	COG0604	alcohol dehydrogenase
D6270_RS16580	COG0746	molybdenum cofactor guanylyltransferase activity
D6270_RS16600	COG1522	sequence-specific DNA binding
D6270_RS16605	COG1309	transcriptional regulator
D6270_RS16630	COG3396	Phenylacetate-CoA oxygenase
D6270_RS16635	COG3460	Phenylacetate-CoA oxygenase
D6270_RS16640	COG3396	Phenylacetate-CoA oxygenase
D6270_RS16645	COG2151	metal-sulfur cluster biosynthetic enzyme
D6270_RS16650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D6270_RS16660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6270_RS16675	COG1733	regulation of RNA biosynthetic process
D6270_RS16680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D6270_RS16695	COG1716	ATPase activity
D6270_RS16700	COG1716	ATPase activity
D6270_RS16715	COG0768	penicillin binding
D6270_RS16720	COG0515	serine threonine protein kinase
D6270_RS16725	COG3764	Sortase (surface protein transpeptidase)
D6270_RS16730	COG3764	Sortase (surface protein transpeptidase)
D6270_RS16745	COG3764	Sortase (surface protein transpeptidase)
D6270_RS16760	COG0705	Rhomboid family
D6270_RS16790	COG0515	serine threonine protein kinase
D6270_RS16820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D6270_RS16835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D6270_RS16840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D6270_RS16845	COG0592	DNA-directed DNA polymerase activity
D6270_RS16860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D6270_RS16865	COG0594	ribonuclease P activity
D6270_RS16870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D6270_RS16875	COG0706	membrane insertase activity
D6270_RS16885	COG0357	Ribosomal RNA small subunit methyltransferase G
D6270_RS16890	COG1192	Involved in chromosome partitioning
D6270_RS16905	COG3118	belongs to the thioredoxin family
D6270_RS16910	COG0492	ferredoxin-NADP+ reductase activity
D6270_RS16920	COG1595	DNA-templated transcription, initiation
D6270_RS16925	COG0515	serine threonine protein kinase
D6270_RS16925	COG2815	serine threonine protein kinase
D6270_RS16960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6270_RS16985	COG0360	Binds together with S18 to 16S ribosomal RNA
D6270_RS16990	COG0629	single-stranded DNA binding
D6270_RS16995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D6270_RS17000	COG0359	binds to the 23S rRNA
D6270_RS17005	COG0534	Mate efflux family protein
D6270_RS17010	COG0305	Participates in initiation and elongation during chromosome replication
D6270_RS17035	COG2814	Major facilitator Superfamily
D6270_RS17055	COG0626	cystathionine gamma-synthase activity
D6270_RS17060	COG1950	PFAM Membrane protein of
D6270_RS17065	COG0662	Cupin 2, conserved barrel domain protein
D6270_RS17090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D6270_RS17095	COG3152	Membrane
D6270_RS17105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D6270_RS17110	COG1609	Transcriptional regulator
D6270_RS17115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D6270_RS17120	COG1271	oxidase subunit
D6270_RS17125	COG1294	oxidase, subunit
D6270_RS17130	COG4988	ABC transporter
D6270_RS17140	COG0561	phosphatase activity
D6270_RS17150	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D6270_RS17155	COG0789	Transcriptional regulator
D6270_RS17170	COG1131	(ABC) transporter
D6270_RS17195	COG0561	phosphatase activity
D6270_RS17200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D6270_RS17210	COG2837	iron assimilation
D6270_RS17215	COG2372	response to copper ion
D6270_RS17225	COG1999	signal sequence binding
D6270_RS17245	COG0006	proline dipeptidase activity
D6270_RS17265	COG0653	protein targeting
D6270_RS17280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6270_RS17380	COG1960	acyl-CoA dehydrogenase activity
D6270_RS17405	COG1595	DNA-templated transcription, initiation
D6270_RS17410	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS17465	COG0745	RESPONSE REGULATOR receiver
D6270_RS17470	COG2205	protein histidine kinase activity
D6270_RS17490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D6270_RS17505	COG0477	Major facilitator Superfamily
D6270_RS17520	COG3467	pyridoxamine 5'-phosphate
D6270_RS17525	COG2353	YceI-like domain
D6270_RS17545	COG1191	sigma factor activity
D6270_RS17550	COG1191	sigma factor activity
D6270_RS17585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D6270_RS17655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D6270_RS17675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D6270_RS17720	COG0358	DNA primase activity
D6270_RS17765	COG1674	ftsk spoiiie
D6270_RS17825	COG0151	Belongs to the GarS family
D6270_RS17840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D6270_RS17850	COG2197	response regulator
D6270_RS17885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D6270_RS17890	COG0047	phosphoribosylformylglycinamidine synthase activity
D6270_RS17895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D6270_RS17905	COG1196	nuclear chromosome segregation
D6270_RS17905	COG0741	lytic transglycosylase activity
D6270_RS17905	COG0739	heme binding
D6270_RS17925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D6270_RS17960	COG1643	Atp-dependent helicase
D6270_RS17970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D6270_RS17970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D6270_RS17975	COG0785	Cytochrome C biogenesis protein
D6270_RS17985	COG1126	abc transporter atp-binding protein
D6270_RS17990	COG0765	amino acid transport
D6270_RS18005	COG2197	response regulator
D6270_RS18010	COG0302	gtp cyclohydrolase
D6270_RS18030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D6270_RS18035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D6270_RS18075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D6270_RS18080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D6270_RS18090	COG0513	Belongs to the DEAD box helicase family
D6270_RS18105	COG0789	Transcriptional regulator
D6270_RS18115	COG1196	nuclear chromosome segregation
D6270_RS18115	COG0741	lytic transglycosylase activity
D6270_RS18115	COG0739	heme binding
D6270_RS18120	COG0667	Aldo Keto reductase
D6270_RS18130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D6270_RS18135	COG0579	oxidoreductase
D6270_RS18160	COG1252	NADH dehydrogenase
D6270_RS18175	COG1846	Transcriptional regulator
D6270_RS18270	COG0739	heme binding
D6270_RS18270	COG0741	lytic transglycosylase activity
D6270_RS18270	COG1196	nuclear chromosome segregation
D6270_RS18275	COG0671	phosphoesterase, PA-phosphatase related
D6270_RS18295	COG1937	Protein conserved in bacteria
D6270_RS18305	COG0306	phosphate transporter
D6270_RS18325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D6270_RS18330	COG0494	nUDIX hydrolase
D6270_RS18330	COG0406	alpha-ribazole phosphatase activity
D6270_RS18355	COG0456	acetyltransferase
D6270_RS18360	COG0737	Belongs to the 5'-nucleotidase family
D6270_RS18385	COG0789	Transcriptional regulator
D6270_RS18420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6270_RS18425	COG1609	Transcriptional regulator
D6270_RS18430	COG0745	RESPONSE REGULATOR receiver
D6270_RS18455	COG2897	thiosulfate sulfurtransferase activity
D6270_RS18485	COG3485	protocatechuate 3,4-dioxygenase
D6270_RS18490	COG0735	belongs to the Fur family
D6270_RS18500	COG1490	D-aminoacyl-tRNA deacylase activity
D6270_RS18515	COG4552	Acetyltransferase involved in intracellular survival and related
D6270_RS18545	COG2318	DinB family
D6270_RS18565	COG1733	regulation of RNA biosynthetic process
D6270_RS18610	COG0438	transferase activity, transferring glycosyl groups
D6270_RS18655	COG0588	phosphoglycerate mutase activity
D6270_RS18670	COG5002	protein histidine kinase activity
D6270_RS18690	COG1329	Transcriptional regulator
D6270_RS18695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D6270_RS18700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D6270_RS18730	COG0215	cysteine-tRNA ligase activity
D6270_RS18735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D6270_RS18745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D6270_RS18755	COG3842	ATPase activity
D6270_RS18780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6270_RS18800	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D6270_RS18815	COG2197	response regulator
D6270_RS18820	COG4585	Histidine kinase
D6270_RS18830	COG0666	response to abiotic stimulus
D6270_RS18855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D6270_RS18875	COG1105	Belongs to the carbohydrate kinase PfkB family
D6270_RS18885	COG1940	carbohydrate kinase activity
D6270_RS18905	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D6270_RS18910	COG0463	Glycosyl transferase, family 2
D6270_RS18960	COG1132	(ABC) transporter
D6270_RS18965	COG1595	DNA-templated transcription, initiation
D6270_RS18985	COG3321	synthase
D6270_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS18985	COG0604	alcohol dehydrogenase
D6270_RS18995	COG0395	ABC-type sugar transport system, permease component
D6270_RS19045	COG4251	negative regulation of phosphorylation
D6270_RS19050	COG2197	response regulator
D6270_RS19070	COG0477	Major facilitator Superfamily
D6270_RS19080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D6270_RS19080	COG1263	PTS System
D6270_RS19085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D6270_RS19090	COG1737	Transcriptional regulator
D6270_RS19125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D6270_RS19160	COG1061	Type III restriction enzyme res subunit
D6270_RS19175	COG0006	proline dipeptidase activity
D6270_RS19180	COG4934	collagen metabolic process
D6270_RS19225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D6270_RS19230	COG1120	ATPase activity
D6270_RS19235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS19240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS19260	COG1278	Cold shock
D6270_RS19265	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D6270_RS19270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D6270_RS19280	COG2814	Major facilitator Superfamily
D6270_RS19305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D6270_RS19315	COG2252	PERMEase
D6270_RS19335	COG0667	Aldo Keto reductase
D6270_RS19340	COG2267	carboxylic ester hydrolase activity
D6270_RS19355	COG0515	serine threonine protein kinase
D6270_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS19365	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS19370	COG0583	DNA-binding transcription factor activity
D6270_RS19450	COG1309	transcriptional regulator
D6270_RS19460	COG0697	spore germination
D6270_RS19465	COG1846	Transcriptional regulator
D6270_RS19525	COG2318	DinB family
D6270_RS19535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D6270_RS19565	COG2205	protein histidine kinase activity
D6270_RS19570	COG0277	FAD linked oxidase domain protein
D6270_RS19570	COG0247	lactate metabolic process
D6270_RS19575	COG0583	DNA-binding transcription factor activity
D6270_RS19580	COG5006	permease, DMT superfamily
D6270_RS19600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6270_RS19615	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS19620	COG1024	Enoyl-CoA hydratase
D6270_RS19655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D6270_RS19670	COG0259	pyridoxamine-phosphate oxidase activity
D6270_RS19680	COG0577	efflux transmembrane transporter activity
D6270_RS19680	COG1136	(ABC) transporter
D6270_RS19685	COG0577	efflux transmembrane transporter activity
D6270_RS19685	COG1136	(ABC) transporter
D6270_RS19700	COG0745	RESPONSE REGULATOR receiver
D6270_RS19705	COG2205	protein histidine kinase activity
D6270_RS19710	COG4821	SIS domain
D6270_RS19720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D6270_RS19790	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS19800	COG1960	acyl-CoA dehydrogenase activity
D6270_RS19805	COG1960	acyl-CoA dehydrogenase activity
D6270_RS19825	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS19830	COG1960	acyl-CoA dehydrogenase activity
D6270_RS19870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D6270_RS19880	COG0346	lactoylglutathione lyase activity
D6270_RS19895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D6270_RS19900	COG1024	Enoyl-CoA hydratase
D6270_RS19915	COG0702	epimerase
D6270_RS19940	COG2234	aminopeptidase activity
D6270_RS19970	COG0501	Belongs to the peptidase M48B family
D6270_RS19985	COG1960	acyl-CoA dehydrogenase activity
D6270_RS19995	COG1309	transcriptional regulator
D6270_RS20025	COG1024	Enoyl-CoA hydratase
D6270_RS20065	COG1278	Cold shock
D6270_RS20070	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D6270_RS20080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D6270_RS20090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D6270_RS20095	COG4521	taurine ABC transporter
D6270_RS20105	COG2175	clavaminate synthase activity
D6270_RS20110	COG2226	methyltransferase
D6270_RS20150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20160	COG0649	NAD binding
D6270_RS20170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D6270_RS20175	COG1034	ATP synthesis coupled electron transport
D6270_RS20180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D6270_RS20185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20190	COG0839	Belongs to the complex I subunit 6 family
D6270_RS20195	COG0713	ATP synthesis coupled electron transport
D6270_RS20200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D6270_RS20210	COG1007	ATP synthesis coupled electron transport
D6270_RS20225	COG0179	Fumarylacetoacetate (FAA) hydrolase
D6270_RS20235	COG3104	oligopeptide transport
D6270_RS20240	COG0142	geranyltranstransferase activity
D6270_RS20280	COG0561	phosphatase activity
D6270_RS20310	COG0346	lactoylglutathione lyase activity
D6270_RS20340	COG0702	epimerase
D6270_RS20345	COG1733	regulation of RNA biosynthetic process
D6270_RS20355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D6270_RS20355	COG0674	pyruvate-flavodoxin oxidoreductase activity
D6270_RS20375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D6270_RS20395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D6270_RS20400	COG0839	Belongs to the complex I subunit 6 family
D6270_RS20405	COG0713	ATP synthesis coupled electron transport
D6270_RS20410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D6270_RS20420	COG1007	ATP synthesis coupled electron transport
D6270_RS20425	COG1970	mechanosensitive ion channel activity
D6270_RS20430	COG0501	Belongs to the peptidase M48B family
D6270_RS20435	COG3304	Inner membrane component domain
D6270_RS20455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D6270_RS20460	COG1403	HNH endonuclease
D6270_RS20465	COG1666	GTP binding
D6270_RS20495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6270_RS20500	COG2030	dehydratase
D6270_RS20510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D6270_RS20525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D6270_RS20530	COG0436	Aminotransferase
D6270_RS20550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D6270_RS20555	COG0081	regulation of translation
D6270_RS20565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D6270_RS20570	COG0222	ribosome binding
D6270_RS20580	COG0085	RNA polymerase activity
D6270_RS20585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D6270_RS20590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D6270_RS20595	COG0049	tRNA binding
D6270_RS20600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D6270_RS20625	COG0051	transcription antitermination factor activity, RNA binding
D6270_RS20630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D6270_RS20635	COG0088	Forms part of the polypeptide exit tunnel
D6270_RS20640	COG0089	rRNA binding
D6270_RS20645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D6270_RS20650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D6270_RS20655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D6270_RS20660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D6270_RS20665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D6270_RS20670	COG0255	Belongs to the universal ribosomal protein uL29 family
D6270_RS20675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D6270_RS20680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D6270_RS20685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D6270_RS20690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D6270_RS20695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D6270_RS20705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D6270_RS20710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D6270_RS20715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D6270_RS20720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D6270_RS20725	COG1841	ribosomal large subunit assembly
D6270_RS20730	COG0200	Binds to the 23S rRNA
D6270_RS20740	COG0563	adenylate kinase activity
D6270_RS20750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D6270_RS20755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D6270_RS20760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D6270_RS20765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D6270_RS20770	COG0202	RNA polymerase activity
D6270_RS20775	COG0203	ribosomal protein L17
D6270_RS20780	COG0101	tRNA pseudouridine synthase activity
D6270_RS20795	COG0488	(ABC) transporter
D6270_RS20800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D6270_RS20805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D6270_RS20810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D6270_RS20820	COG1072	(Pantothenic acid kinase))
D6270_RS20840	COG4566	intracellular signal transduction
D6270_RS20850	COG0747	negative chemotaxis
D6270_RS20855	COG3795	YCII-related domain
D6270_RS20860	COG4941	Belongs to the sigma-70 factor family
D6270_RS20895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D6270_RS20900	COG0736	holo-[acyl-carrier-protein] synthase activity
D6270_RS20910	COG3189	MarR family transcriptional regulator
D6270_RS20925	COG0802	atpase or kinase
D6270_RS20950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D6270_RS20980	COG0726	polysaccharide deacetylase
D6270_RS20985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D6270_RS21000	COG0395	ABC-type sugar transport system, permease component
D6270_RS21005	COG1175	transmembrane transport
D6270_RS21015	COG1609	Transcriptional regulator
D6270_RS21020	COG4221	oxidoreductase activity
D6270_RS21030	COG0583	DNA-binding transcription factor activity
D6270_RS21040	COG2197	response regulator
D6270_RS21045	COG1595	DNA-templated transcription, initiation
D6270_RS21055	COG0516	GMP reductase activity
D6270_RS21090	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS21110	COG0519	Catalyzes the synthesis of GMP from XMP
D6270_RS21110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D6270_RS21145	COG2197	response regulator
D6270_RS21185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D6270_RS21205	COG0714	Associated with various cellular activities
D6270_RS21215	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D6270_RS21220	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D6270_RS21225	COG0045	succinate-CoA ligase (ADP-forming) activity
D6270_RS21255	COG0138	bifunctional purine biosynthesis protein purh
D6270_RS21265	COG1714	RDD family
D6270_RS21270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D6270_RS21285	COG0039	L-malate dehydrogenase activity
D6270_RS21305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6270_RS21310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6270_RS21325	COG0754	glutathionylspermidine amidase activity
D6270_RS21330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D6270_RS21335	COG0180	Tryptophanyl-tRNA synthetase
D6270_RS21355	COG1295	ribonuclease BN
D6270_RS21360	COG1686	Belongs to the peptidase S11 family
D6270_RS21365	COG1408	metallophosphoesterase
D6270_RS21400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D6270_RS21415	COG2009	succinate dehydrogenase
D6270_RS21470	COG1309	transcriptional regulator
D6270_RS21480	COG1595	DNA-templated transcription, initiation
D6270_RS21515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D6270_RS21535	COG1216	Glycosyl transferase, family 2
D6270_RS21545	COG1083	cytidylyl-transferase
D6270_RS21550	COG2089	acid synthase
D6270_RS21565	COG1473	amidohydrolase
D6270_RS21565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D6270_RS21570	COG1744	ABC transporter substrate-binding protein PnrA-like
D6270_RS21575	COG3845	ABC transporter
D6270_RS21580	COG4603	Belongs to the binding-protein-dependent transport system permease family
D6270_RS21585	COG1079	Belongs to the binding-protein-dependent transport system permease family
D6270_RS21600	COG1404	Belongs to the peptidase S8 family
D6270_RS21620	COG2814	Major facilitator Superfamily
D6270_RS21625	COG0583	DNA-binding transcription factor activity
D6270_RS21635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D6270_RS21660	COG2205	protein histidine kinase activity
D6270_RS21665	COG0745	RESPONSE REGULATOR receiver
D6270_RS21670	COG1595	DNA-templated transcription, initiation
D6270_RS21690	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS21695	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS21740	COG4770	biotin carboxylase activity
D6270_RS21750	COG0424	maF-like protein
D6270_RS21760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6270_RS21775	COG1024	Enoyl-CoA hydratase
D6270_RS21800	COG1376	ErfK ybiS ycfS ynhG family protein
D6270_RS21815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D6270_RS21820	COG1396	sequence-specific DNA binding
D6270_RS21835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D6270_RS21855	COG1595	DNA-templated transcription, initiation
D6270_RS21860	COG0745	RESPONSE REGULATOR receiver
D6270_RS21865	COG0784	Response regulator, receiver
D6270_RS21865	COG2198	Histidine kinase
D6270_RS21865	COG5002	protein histidine kinase activity
D6270_RS21875	COG2172	sigma factor antagonist activity
D6270_RS21880	COG1366	Belongs to the anti-sigma-factor antagonist family
D6270_RS21885	COG1366	Belongs to the anti-sigma-factor antagonist family
D6270_RS21890	COG2255	four-way junction helicase activity
D6270_RS21895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D6270_RS21910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D6270_RS21920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6270_RS21945	COG4104	PAAR repeat-containing protein
D6270_RS21945	COG3209	COG3209 Rhs family protein
D6270_RS21980	COG1331	Highly conserved protein containing a thioredoxin domain
D6270_RS21990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D6270_RS22000	COG0436	Aminotransferase
D6270_RS22035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D6270_RS22050	COG1414	Transcriptional regulator
D6270_RS22055	COG0251	oxidation-reduction process
D6270_RS22060	COG2610	gluconate transmembrane transporter activity
D6270_RS22085	COG2894	cell division
D6270_RS22115	COG3920	Histidine kinase
D6270_RS22120	COG2197	response regulator
D6270_RS22140	COG2885	chlorophyll binding
D6270_RS22180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D6270_RS22195	COG0667	Aldo Keto reductase
D6270_RS22200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D6270_RS22225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6270_RS22230	COG0450	alkyl hydroperoxide reductase
D6270_RS22245	COG1136	(ABC) transporter
D6270_RS22280	COG0114	fumarate hydratase activity
D6270_RS22290	COG1362	aminopeptidase activity
D6270_RS22295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D6270_RS22295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D6270_RS22320	COG0778	Nitroreductase
D6270_RS22325	COG1722	exodeoxyribonuclease VII activity
D6270_RS22330	COG1570	exodeoxyribonuclease VII activity
D6270_RS22340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D6270_RS22355	COG0012	GTP binding
D6270_RS22380	COG0789	Transcriptional regulator
D6270_RS22385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D6270_RS22425	COG1842	Phage shock protein A
D6270_RS22450	COG4941	Belongs to the sigma-70 factor family
D6270_RS22455	COG3795	YCII-related domain
D6270_RS22535	COG0148	phosphopyruvate hydratase activity
D6270_RS22560	COG0395	ABC-type sugar transport system, permease component
D6270_RS22565	COG1175	transmembrane transport
D6270_RS22585	COG1609	Transcriptional regulator
D6270_RS22595	COG1217	gtp-binding protein TYPA
D6270_RS22605	COG0747	negative chemotaxis
D6270_RS22610	COG0601	transmembrane transport
D6270_RS22615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6270_RS22620	COG0444	Belongs to the ABC transporter superfamily
D6270_RS22625	COG4608	Belongs to the ABC transporter superfamily
D6270_RS22630	COG4166	transmembrane transport
D6270_RS22635	COG0601	transmembrane transport
D6270_RS22640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6270_RS22650	COG4608	Belongs to the ABC transporter superfamily
D6270_RS22670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6270_RS22700	COG0110	maltose O-acetyltransferase activity
D6270_RS22710	COG0515	serine threonine protein kinase
D6270_RS22720	COG1132	(ABC) transporter
D6270_RS22730	COG2197	response regulator
D6270_RS22735	COG2912	Transglutaminase-like superfamily
D6270_RS22765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6270_RS22770	COG1611	Belongs to the LOG family
D6270_RS22775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D6270_RS22785	COG0519	Catalyzes the synthesis of GMP from XMP
D6270_RS22790	COG1024	Enoyl-CoA hydratase
D6270_RS22805	COG1595	DNA-templated transcription, initiation
D6270_RS22815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D6270_RS22820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D6270_RS22855	COG0598	Magnesium transport protein CorA
D6270_RS22870	COG2814	Major facilitator Superfamily
D6270_RS22885	COG2095	MarC family integral membrane protein
D6270_RS22890	COG1432	Conserved Protein
D6270_RS22895	COG2267	carboxylic ester hydrolase activity
D6270_RS22900	COG0513	Belongs to the DEAD box helicase family
D6270_RS22930	COG0596	Alpha beta hydrolase
D6270_RS22995	COG0210	DNA helicase
D6270_RS23040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D6270_RS23090	COG3480	Lon protease (S16) C-terminal proteolytic domain
D6270_RS23100	COG1615	UPF0182 protein
D6270_RS23125	COG0753	catalase activity
D6270_RS23135	COG0483	inositol monophosphate 1-phosphatase activity
D6270_RS23140	COG1309	transcriptional regulator
D6270_RS23145	COG2076	Multidrug Resistance protein
D6270_RS23150	COG1162	GTPase activity
D6270_RS23155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D6270_RS23165	COG2135	peptidase activity
D6270_RS23175	COG1595	DNA-templated transcription, initiation
D6270_RS23180	COG5662	AntiSigma factor
D6270_RS23200	COG0242	peptide deformylase activity
D6270_RS23235	COG1966	Carbon starvation protein
D6270_RS23245	COG2182	Extracellular solute-binding protein
D6270_RS23250	COG1175	transmembrane transport
D6270_RS23255	COG0395	ABC-type sugar transport system, permease component
D6270_RS23260	COG1472	Belongs to the glycosyl hydrolase 3 family
D6270_RS23265	COG0363	glucosamine-6-phosphate deaminase activity
D6270_RS23270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D6270_RS23285	COG1597	lipid kinase activity
D6270_RS23300	COG2172	sigma factor antagonist activity
D6270_RS23320	COG1017	nitric oxide dioxygenase activity
D6270_RS23320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D6270_RS23325	COG1959	2 iron, 2 sulfur cluster binding
D6270_RS23330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D6270_RS23335	COG0142	geranyltranstransferase activity
D6270_RS23355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6270_RS23410	COG4106	trans-aconitate 2-methyltransferase activity
D6270_RS23415	COG1126	abc transporter atp-binding protein
D6270_RS23435	COG0281	malic enzyme
D6270_RS23440	COG0604	alcohol dehydrogenase
D6270_RS23460	COG0542	response to heat
D6270_RS23495	COG2205	protein histidine kinase activity
D6270_RS23500	COG0745	RESPONSE REGULATOR receiver
D6270_RS23515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D6270_RS23520	COG0726	polysaccharide deacetylase
D6270_RS23540	COG5002	protein histidine kinase activity
D6270_RS23565	COG0791	NLP P60 protein
D6270_RS23565	COG3883	PFAM NLP P60 protein
D6270_RS23635	COG0768	penicillin binding
D6270_RS23650	COG2205	protein histidine kinase activity
D6270_RS23670	COG3285	dna ligase
D6270_RS23670	COG1793	dna ligase
D6270_RS23675	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D6270_RS23690	COG3903	Transcriptional regulator
D6270_RS23690	COG3629	intracellular signal transduction
D6270_RS23745	COG0018	arginyl-trna synthetase
D6270_RS23750	COG0019	diaminopimelate decarboxylase activity
D6270_RS23755	COG0460	homoserine dehydrogenase
D6270_RS23760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D6270_RS23765	COG0083	homoserine kinase activity
D6270_RS23775	COG1316	TRANSCRIPTIONal
D6270_RS23780	COG0254	rRNA binding
D6270_RS23785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D6270_RS23790	COG2890	protein-(glutamine-N5) methyltransferase activity
D6270_RS23800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D6270_RS23805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D6270_RS23825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D6270_RS23830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D6270_RS23835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D6270_RS23840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D6270_RS23845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D6270_RS23850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D6270_RS23855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D6270_RS23870	COG2197	response regulator
D6270_RS23875	COG4585	Histidine kinase
D6270_RS23890	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6270_RS23905	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D6270_RS23960	COG0183	Belongs to the thiolase family
D6270_RS23975	COG0745	RESPONSE REGULATOR receiver
D6270_RS23980	COG5002	protein histidine kinase activity
D6270_RS24060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D6270_RS24060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D6270_RS24100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D6270_RS24105	COG0857	belongs to the CobB CobQ family
D6270_RS24105	COG0280	phosphate acetyltransferase
D6270_RS24110	COG0205	6-phosphofructokinase activity
D6270_RS24120	COG4565	transcriptional regulatory protein
D6270_RS24125	COG3290	protein histidine kinase activity
D6270_RS24130	COG1301	dicarboxylic acid transport
D6270_RS24140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D6270_RS24145	COG3281	Trehalose synthase
D6270_RS24150	COG0366	Alpha amylase catalytic
D6270_RS24155	COG0366	Alpha amylase catalytic
D6270_RS24185	COG1132	(ABC) transporter
D6270_RS24190	COG1132	(ABC) transporter
D6270_RS24195	COG1131	(ABC) transporter
D6270_RS24210	COG2197	response regulator
D6270_RS24225	COG1376	ErfK ybiS ycfS ynhG family protein
D6270_RS24240	COG0726	polysaccharide deacetylase
D6270_RS24425	COG1760	l-serine dehydratase
D6270_RS24430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D6270_RS24435	COG0509	glycine decarboxylation via glycine cleavage system
D6270_RS24440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D6270_RS24460	COG4166	transmembrane transport
D6270_RS24465	COG0601	transmembrane transport
D6270_RS24470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6270_RS24475	COG0444	Belongs to the ABC transporter superfamily
D6270_RS24480	COG4608	Belongs to the ABC transporter superfamily
D6270_RS24485	COG2860	membrane
D6270_RS24515	COG0482	sulfurtransferase activity
D6270_RS24535	COG4221	oxidoreductase activity
D6270_RS24545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D6270_RS24555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D6270_RS24560	COG0154	amidase activity
D6270_RS24570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D6270_RS24575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D6270_RS24585	COG2409	Drug exporters of the RND superfamily
D6270_RS24605	COG2133	pyrroloquinoline quinone binding
D6270_RS24630	COG0440	acetolactate synthase activity
D6270_RS24635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D6270_RS24660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D6270_RS24670	COG0506	proline dehydrogenase activity
D6270_RS24675	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS24690	COG0473	3-isopropylmalate dehydrogenase activity
D6270_RS24695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D6270_RS24700	COG2957	Belongs to the agmatine deiminase family
D6270_RS24710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D6270_RS24715	COG1609	Transcriptional regulator
D6270_RS24725	COG4608	Belongs to the ABC transporter superfamily
D6270_RS24730	COG0601	transmembrane transport
D6270_RS24735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6270_RS24740	COG0444	Belongs to the ABC transporter superfamily
D6270_RS24750	COG1472	Belongs to the glycosyl hydrolase 3 family
D6270_RS24765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D6270_RS24805	COG1733	regulation of RNA biosynthetic process
D6270_RS24830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS24835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS24840	COG1120	ATPase activity
D6270_RS24845	COG4607	ABC-type enterochelin transport system periplasmic component
D6270_RS24875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D6270_RS24895	COG2018	Roadblock/LC7 domain
D6270_RS24915	COG2018	Roadblock/LC7 domain
D6270_RS24920	COG5002	protein histidine kinase activity
D6270_RS24930	COG0179	Fumarylacetoacetate (FAA) hydrolase
D6270_RS24935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D6270_RS24975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D6270_RS24980	COG0066	3-isopropylmalate dehydratase activity
D6270_RS24990	COG0776	regulation of translation
D6270_RS25000	COG1920	GTP binding
D6270_RS25010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D6270_RS25015	COG1181	Belongs to the D-alanine--D-alanine ligase family
D6270_RS25030	COG0351	phosphomethylpyrimidine kinase
D6270_RS25035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D6270_RS25040	COG1461	Dihydroxyacetone kinase
D6270_RS25045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D6270_RS25050	COG0742	ribosomal rna small subunit methyltransferase
D6270_RS25055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D6270_RS25070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D6270_RS25075	COG0571	ribonuclease III activity
D6270_RS25080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D6270_RS25085	COG1733	regulation of RNA biosynthetic process
D6270_RS25090	COG2340	Cysteine-rich secretory protein family
D6270_RS25095	COG1254	Belongs to the acylphosphatase family
D6270_RS25110	COG1196	nuclear chromosome segregation
D6270_RS25115	COG0477	Major facilitator Superfamily
D6270_RS25170	COG0228	four-way junction DNA binding
D6270_RS25175	COG1837	Belongs to the UPF0109 family
D6270_RS25180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D6270_RS25185	COG0336	Belongs to the RNA methyltransferase TrmD family
D6270_RS25190	COG0335	large ribosomal subunit rRNA binding
D6270_RS25195	COG0681	Belongs to the peptidase S26 family
D6270_RS25210	COG0681	Belongs to the peptidase S26 family
D6270_RS25225	COG0792	nuclease activity
D6270_RS25240	COG1191	sigma factor activity
D6270_RS25255	COG0052	Belongs to the universal ribosomal protein uS2 family
D6270_RS25260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D6270_RS25265	COG0528	UMP kinase activity
D6270_RS25270	COG0233	cytoplasmic translational termination
D6270_RS25280	COG4974	Belongs to the 'phage' integrase family
D6270_RS25330	COG2188	Transcriptional regulator
D6270_RS25335	COG2226	methyltransferase
D6270_RS25340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D6270_RS25370	COG4181	ATPase activity
D6270_RS25375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D6270_RS25385	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS25410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D6270_RS25430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D6270_RS25435	COG3842	ATPase activity
D6270_RS25440	COG1176	ABC-type spermidine putrescine transport system, permease component I
D6270_RS25445	COG1177	transmembrane transport
D6270_RS25450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D6270_RS25480	COG2508	Transcriptional regulator
D6270_RS25485	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS25490	COG2239	Acts as a magnesium transporter
D6270_RS25500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D6270_RS25505	COG0750	zinc metalloprotease
D6270_RS25510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D6270_RS25525	COG0442	prolyl-tRNA aminoacylation
D6270_RS25545	COG0779	Required for maturation of 30S ribosomal subunits
D6270_RS25560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D6270_RS25570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D6270_RS25575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D6270_RS25615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6270_RS25620	COG0601	transmembrane transport
D6270_RS25625	COG0747	negative chemotaxis
D6270_RS25630	COG0455	bacterial-type flagellum organization
D6270_RS25650	COG3266	domain, Protein
D6270_RS25655	COG1404	Belongs to the peptidase S8 family
D6270_RS25685	COG1674	ftsk spoiiie
D6270_RS25695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D6270_RS25700	COG1185	polyribonucleotide nucleotidyltransferase activity
D6270_RS25705	COG0612	Peptidase, M16
D6270_RS25710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D6270_RS25730	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D6270_RS25735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D6270_RS25740	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D6270_RS25770	COG2208	phosphoserine phosphatase activity
D6270_RS25770	COG2770	Histidine kinase
D6270_RS25775	COG4999	Histidine kinase
D6270_RS25775	COG3437	response regulator, receiver
D6270_RS25775	COG3850	Histidine kinase
D6270_RS25775	COG2205	protein histidine kinase activity
D6270_RS25785	COG1674	ftsk spoiiie
D6270_RS25795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6270_RS25805	COG1546	Belongs to the CinA family
D6270_RS25805	COG1058	Belongs to the CinA family
D6270_RS25810	COG1396	sequence-specific DNA binding
D6270_RS25815	COG0783	Belongs to the Dps family
D6270_RS25830	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS25835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D6270_RS25845	COG1201	RNA secondary structure unwinding
D6270_RS25850	COG2207	Transcriptional regulator
D6270_RS25850	COG1917	Cupin 2, conserved barrel domain protein
D6270_RS25885	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS25890	COG1672	PFAM Archaeal ATPase
D6270_RS25890	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D6270_RS25900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D6270_RS25915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6270_RS25930	COG0765	amino acid transport
D6270_RS25935	COG0765	amino acid transport
D6270_RS25940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6270_RS25945	COG1126	abc transporter atp-binding protein
D6270_RS25950	COG0745	RESPONSE REGULATOR receiver
D6270_RS25965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D6270_RS25980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D6270_RS25990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D6270_RS25995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D6270_RS26005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D6270_RS26050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D6270_RS26055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D6270_RS26060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D6270_RS26095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D6270_RS26125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D6270_RS26130	COG2186	Transcriptional regulator
D6270_RS26135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D6270_RS26160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6270_RS26165	COG4565	transcriptional regulatory protein
D6270_RS26170	COG3290	protein histidine kinase activity
D6270_RS26180	COG0372	Belongs to the citrate synthase family
D6270_RS26185	COG0372	Belongs to the citrate synthase family
D6270_RS26195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D6270_RS26200	COG0612	Peptidase, M16
D6270_RS26215	COG1802	Transcriptional regulator
D6270_RS26220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D6270_RS26240	COG1435	thymidine kinase activity
D6270_RS26275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D6270_RS26290	COG0745	RESPONSE REGULATOR receiver
D6270_RS26295	COG2205	protein histidine kinase activity
D6270_RS26320	COG0756	dUTP diphosphatase activity
D6270_RS26335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D6270_RS26340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D6270_RS26345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D6270_RS26375	COG0569	domain protein
D6270_RS26380	COG0531	amino acid
D6270_RS26385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D6270_RS26445	COG0477	Major facilitator Superfamily
D6270_RS26495	COG1609	Transcriptional regulator
D6270_RS26505	COG1175	transmembrane transport
D6270_RS26510	COG0395	ABC-type sugar transport system, permease component
D6270_RS26515	COG1472	Belongs to the glycosyl hydrolase 3 family
D6270_RS26520	COG2124	cytochrome p450
D6270_RS26560	COG1404	Belongs to the peptidase S8 family
D6270_RS26565	COG1674	ftsk spoiiie
D6270_RS26585	COG4842	Belongs to the WXG100 family
D6270_RS26645	COG1280	lysine exporter protein (LysE YggA)
D6270_RS26650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D6270_RS26675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS26680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS26690	COG0586	Pfam SNARE associated Golgi protein
D6270_RS26695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D6270_RS26705	COG1799	cell septum assembly
D6270_RS26725	COG2040	homocysteine
D6270_RS26735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D6270_RS26745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D6270_RS26750	COG0531	amino acid
D6270_RS26760	COG1024	Enoyl-CoA hydratase
D6270_RS26780	COG1960	acyl-CoA dehydrogenase activity
D6270_RS26790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D6270_RS26790	COG2111	Na H antiporter
D6270_RS26795	COG1006	Multisubunit Na H antiporter MnhC subunit
D6270_RS26800	COG0651	ATP synthesis coupled electron transport
D6270_RS26815	COG1320	monovalent cation:proton antiporter activity
D6270_RS26835	COG0489	protein tyrosine kinase activity
D6270_RS26875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D6270_RS26880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D6270_RS26920	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS26955	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS27015	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS27015	COG0604	alcohol dehydrogenase
D6270_RS27015	COG3321	synthase
D6270_RS27040	COG0500	methyltransferase
D6270_RS27045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D6270_RS27065	COG1136	(ABC) transporter
D6270_RS27080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D6270_RS27095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D6270_RS27105	COG0406	alpha-ribazole phosphatase activity
D6270_RS27115	COG1653	transport
D6270_RS27120	COG1175	transmembrane transport
D6270_RS27125	COG0395	ABC-type sugar transport system, permease component
D6270_RS27130	COG1940	carbohydrate kinase activity
D6270_RS27135	COG4213	ABC transporter substrate-binding protein
D6270_RS27145	COG4214	carbohydrate transport
D6270_RS27150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D6270_RS27155	COG0531	amino acid
D6270_RS27165	COG1316	TRANSCRIPTIONal
D6270_RS27170	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6270_RS27170	COG1024	Enoyl-CoA hydratase
D6270_RS27175	COG0183	Belongs to the thiolase family
D6270_RS27195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D6270_RS27200	COG0446	pyridine nucleotide-disulphide oxidoreductase
D6270_RS27210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D6270_RS27215	COG3253	May function as heme-dependent peroxidase
D6270_RS27230	COG0596	Alpha beta hydrolase
D6270_RS27240	COG3220	belongs to the UPF0276 family
D6270_RS27295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D6270_RS27300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D6270_RS27335	COG1653	transport
D6270_RS27380	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS27385	COG0300	oxidoreductase activity
D6270_RS27410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D6270_RS27410	COG0515	serine threonine protein kinase
D6270_RS27425	COG1063	alcohol dehydrogenase
D6270_RS27430	COG0156	8-amino-7-oxononanoate synthase activity
D6270_RS27435	COG0583	DNA-binding transcription factor activity
D6270_RS27445	COG0346	lactoylglutathione lyase activity
D6270_RS27455	COG1072	(Pantothenic acid kinase))
D6270_RS27470	COG2723	6-phospho-beta-galactosidase activity
D6270_RS27525	COG1175	transmembrane transport
D6270_RS27545	COG1404	Belongs to the peptidase S8 family
D6270_RS27560	COG1132	(ABC) transporter
D6270_RS27570	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D6270_RS27575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS27580	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS27585	COG1120	ATPase activity
D6270_RS27595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D6270_RS27605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D6270_RS27610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D6270_RS27630	COG0529	Catalyzes the synthesis of activated sulfate
D6270_RS27635	COG0175	sulfate reduction
D6270_RS27660	COG1960	acyl-CoA dehydrogenase activity
D6270_RS27680	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6270_RS27685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D6270_RS27690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D6270_RS27695	COG0583	DNA-binding transcription factor activity
D6270_RS27700	COG0183	Belongs to the thiolase family
D6270_RS27750	COG1162	GTPase activity
D6270_RS27780	COG0028	Belongs to the TPP enzyme family
D6270_RS27805	COG1802	Transcriptional regulator
D6270_RS27810	COG1309	transcriptional regulator
D6270_RS27815	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS27840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D6270_RS27845	COG2252	PERMEase
D6270_RS27850	COG3608	succinylglutamate desuccinylase aspartoacylase
D6270_RS27850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D6270_RS27885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6270_RS27915	COG0435	Glutathione S-transferase
D6270_RS27930	COG2197	response regulator
D6270_RS27935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6270_RS27940	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS27960	COG3960	tartronate-semialdehyde synthase activity
D6270_RS27975	COG3903	Transcriptional regulator
D6270_RS27975	COG3629	intracellular signal transduction
D6270_RS27985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS27995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D6270_RS28005	COG0436	Aminotransferase
D6270_RS28010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D6270_RS28025	COG0753	catalase activity
D6270_RS28030	COG2084	Dehydrogenase
D6270_RS28035	COG3622	Belongs to the hyi family
D6270_RS28045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D6270_RS28050	COG0395	ABC-type sugar transport system, permease component
D6270_RS28055	COG1175	transmembrane transport
D6270_RS28065	COG2188	Transcriptional regulator
D6270_RS28070	COG2706	6-phosphogluconolactonase activity
D6270_RS28090	COG2351	hydroxyisourate hydrolase activity
D6270_RS28100	COG2233	PERMEase
D6270_RS28110	COG2233	PERMEase
D6270_RS28120	COG0596	Alpha beta hydrolase
D6270_RS28145	COG1288	antiporter activity
D6270_RS28150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D6270_RS28155	COG0746	molybdenum cofactor guanylyltransferase activity
D6270_RS28165	COG2197	response regulator
D6270_RS28185	COG1414	Transcriptional regulator
D6270_RS28190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6270_RS28195	COG4266	Belongs to the allantoicase family
D6270_RS28200	COG0656	L-ascorbic acid biosynthetic process
D6270_RS28225	COG2197	response regulator
D6270_RS28235	COG0673	inositol 2-dehydrogenase activity
D6270_RS28240	COG2188	Transcriptional regulator
D6270_RS28245	COG1879	ABC-type sugar transport system periplasmic component
D6270_RS28255	COG1129	ABC transporter
D6270_RS28260	COG1940	carbohydrate kinase activity
D6270_RS28315	COG2072	flavoprotein involved in K transport
D6270_RS28320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D6270_RS28330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6270_RS28340	COG3629	intracellular signal transduction
D6270_RS28345	COG0156	8-amino-7-oxononanoate synthase activity
D6270_RS28355	COG2030	dehydratase
D6270_RS28360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS28370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D6270_RS28375	COG0159	tryptophan synthase activity
D6270_RS28380	COG0662	Cupin 2, conserved barrel domain protein
D6270_RS28385	COG1960	acyl-CoA dehydrogenase activity
D6270_RS28395	COG0134	indole-3-glycerol-phosphate synthase activity
D6270_RS28410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D6270_RS28415	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D6270_RS28430	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS28440	COG1126	abc transporter atp-binding protein
D6270_RS28445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D6270_RS28450	COG0765	amino acid transport
D6270_RS28455	COG0765	amino acid transport
D6270_RS28470	COG0367	asparagine synthase
D6270_RS28475	COG0477	Major facilitator Superfamily
D6270_RS28485	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS28490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D6270_RS28505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D6270_RS28510	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS28520	COG0405	Gamma-glutamyltransferase
D6270_RS28560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D6270_RS28565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D6270_RS28605	COG2838	Isocitrate dehydrogenase
D6270_RS28625	COG0095	Lipoate-protein ligase
D6270_RS28635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D6270_RS28645	COG1396	sequence-specific DNA binding
D6270_RS28645	COG3800	Transcriptional regulator
D6270_RS28665	COG1960	acyl-CoA dehydrogenase activity
D6270_RS28685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D6270_RS28700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D6270_RS28740	COG1024	Enoyl-CoA hydratase
D6270_RS28745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS28760	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS28780	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS28785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6270_RS28790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6270_RS28800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D6270_RS28815	COG1024	Enoyl-CoA hydratase
D6270_RS28825	COG0483	inositol monophosphate 1-phosphatase activity
D6270_RS28865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D6270_RS28900	COG0559	Belongs to the binding-protein-dependent transport system permease family
D6270_RS28945	COG0688	phosphatidylethanolamine metabolic process
D6270_RS28950	COG1960	acyl-CoA dehydrogenase activity
D6270_RS28960	COG2301	Belongs to the HpcH HpaI aldolase family
D6270_RS28965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D6270_RS28965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D6270_RS28970	COG0604	alcohol dehydrogenase
D6270_RS28975	COG0456	acetyltransferase
D6270_RS28990	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6270_RS29020	COG0583	DNA-binding transcription factor activity
D6270_RS29035	COG2362	D-Aminopeptidase
D6270_RS29040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D6270_RS29050	COG1619	proteins homologs of microcin C7 resistance protein MccF
D6270_RS29065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D6270_RS29080	COG2226	methyltransferase
D6270_RS29100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D6270_RS29145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6270_RS29145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D6270_RS29155	COG2154	pterin-4-alpha-carbinolamine dehydratase
D6270_RS29165	COG4106	trans-aconitate 2-methyltransferase activity
D6270_RS29185	COG0583	DNA-binding transcription factor activity
D6270_RS29195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D6270_RS29200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D6270_RS29210	COG1129	ABC transporter
D6270_RS29215	COG1172	Belongs to the binding-protein-dependent transport system permease family
D6270_RS29220	COG1879	ABC-type sugar transport system periplasmic component
D6270_RS29225	COG0673	inositol 2-dehydrogenase activity
D6270_RS29245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D6270_RS29300	COG1129	ABC transporter
D6270_RS29310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D6270_RS29315	COG1869	D-ribose catabolic process
D6270_RS29345	COG5002	protein histidine kinase activity
D6270_RS29350	COG0745	RESPONSE REGULATOR receiver
D6270_RS29375	COG1012	belongs to the aldehyde dehydrogenase family
D6270_RS29385	COG0517	IMP dehydrogenase activity
D6270_RS29385	COG4175	Glycine betaine
D6270_RS29390	COG4176	ABC-type proline glycine betaine transport system permease component
D6270_RS29405	COG2197	response regulator
D6270_RS29425	COG0569	domain protein
D6270_RS29425	COG2985	domain, Protein
D6270_RS29440	COG1070	Carbohydrate kinase
D6270_RS29450	COG1940	carbohydrate kinase activity
D6270_RS29510	COG2124	cytochrome p450
D6270_RS29515	COG1486	melibiose metabolic process
D6270_RS29555	COG3012	SEC-C Motif Domain Protein
D6270_RS29585	COG0483	inositol monophosphate 1-phosphatase activity
D6270_RS29635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D6270_RS29660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D6270_RS29695	COG2770	Histidine kinase
D6270_RS29695	COG2208	phosphoserine phosphatase activity
D6270_RS29715	COG1793	dna ligase
D6270_RS29765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D6270_RS29770	COG1116	anion transmembrane transporter activity
D6270_RS29775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D6270_RS29780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D6270_RS29800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6270_RS29805	COG0488	(ABC) transporter
D6270_RS29820	COG1515	deoxyribonuclease V activity
D6270_RS29825	COG3268	Saccharopine dehydrogenase
D6270_RS29835	COG1960	acyl-CoA dehydrogenase activity
D6270_RS29845	COG1250	3-hydroxyacyl-CoA dehydrogenase
D6270_RS29845	COG1024	Enoyl-CoA hydratase
D6270_RS29850	COG0789	Transcriptional regulator
D6270_RS29870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D6270_RS29880	COG0488	(ABC) transporter
D6270_RS29895	COG4977	sequence-specific DNA binding
D6270_RS29905	COG1024	Enoyl-CoA hydratase
D6270_RS29920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D6270_RS29925	COG4106	trans-aconitate 2-methyltransferase activity
D6270_RS29950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D6270_RS29970	COG1134	teichoic acid transport
D6270_RS29975	COG1562	ergosterol biosynthetic process
D6270_RS29995	COG1657	PFAM Prenyltransferase squalene oxidase
D6270_RS30020	COG2365	Tyrosine phosphatase family
D6270_RS30030	COG2755	lipolytic protein G-D-S-L family
D6270_RS30040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D6270_RS30125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D6270_RS30135	COG1116	anion transmembrane transporter activity
D6270_RS30165	COG3958	Transketolase
D6270_RS30170	COG3959	Transketolase, thiamine diphosphate binding domain
D6270_RS30300	COG3511	phospholipase C
D6270_RS30310	COG2197	response regulator
D6270_RS30315	COG3851	Histidine kinase
D6270_RS30330	COG0247	lactate metabolic process
D6270_RS30335	COG1139	Iron-sulfur cluster binding protein
D6270_RS30340	COG1556	Lactate utilization protein
D6270_RS30360	COG1672	PFAM Archaeal ATPase
D6270_RS30360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D6270_RS30420	COG0300	oxidoreductase activity
D6270_RS30465	COG0714	Associated with various cellular activities
D6270_RS30490	COG0831	urea catabolic process
D6270_RS30500	COG0832	Belongs to the urease beta subunit family
D6270_RS30500	COG0831	urea catabolic process
D6270_RS30505	COG0804	urea catabolic process
D6270_RS30510	COG0830	nickel cation binding
D6270_RS30515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D6270_RS30520	COG0829	nickel cation binding
D6270_RS30585	COG2409	Drug exporters of the RND superfamily
D6270_RS30590	COG1846	Transcriptional regulator
D6270_RS30640	COG1233	COG1233 Phytoene dehydrogenase and related
D6270_RS30645	COG2130	NADP-dependent
D6270_RS30650	COG2124	cytochrome p450
D6270_RS30670	COG0671	phosphoesterase, PA-phosphatase related
D6270_RS30680	COG2080	2 iron, 2 sulfur cluster binding
D6270_RS30685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D6270_RS30690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D6270_RS30740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D6270_RS30760	COG0019	diaminopimelate decarboxylase activity
D6270_RS30770	COG2837	iron assimilation
D6270_RS30775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D6270_RS30790	COG2272	Belongs to the type-B carboxylesterase lipase family
D6270_RS30825	COG0395	ABC-type sugar transport system, permease component
D6270_RS30830	COG1175	transmembrane transport
D6270_RS30850	COG1652	LysM domain
D6270_RS30885	COG0784	Response regulator, receiver
D6270_RS30890	COG4251	negative regulation of phosphorylation
D6270_RS30895	COG2201	protein-glutamate methylesterase activity
D6270_RS30900	COG1191	sigma factor activity
D6270_RS30940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D6270_RS30960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D6270_RS30965	COG3275	phosphorelay sensor kinase activity
D6270_RS31040	COG0583	DNA-binding transcription factor activity
D6270_RS31050	COG1053	succinate dehydrogenase
D6270_RS31055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D6270_RS31065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D6270_RS31085	COG3360	Dodecin
D6270_RS31105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D6270_RS31110	COG0121	glutamine amidotransferase
D6270_RS31130	COG1609	Transcriptional regulator
D6270_RS31140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D6270_RS31145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D6270_RS31150	COG0297	glycogen (starch) synthase activity
D6270_RS31155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D6270_RS31160	COG0477	Major facilitator Superfamily
D6270_RS31175	COG3629	intracellular signal transduction
D6270_RS31175	COG3903	Transcriptional regulator
D6270_RS31180	COG2124	cytochrome p450
D6270_RS31185	COG2124	cytochrome p450
D6270_RS31200	COG0318	PFAM AMP-dependent synthetase and ligase
D6270_RS31235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D6270_RS31270	COG3433	isochorismatase activity
D6270_RS31270	COG2226	methyltransferase
D6270_RS31270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS31275	COG3433	isochorismatase activity
D6270_RS31275	COG2226	methyltransferase
D6270_RS31275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D6270_RS31305	COG0436	Aminotransferase
D6270_RS31310	COG3483	tryptophan 2,3-dioxygenase activity
D6270_RS31315	COG0745	RESPONSE REGULATOR receiver
D6270_RS31335	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS31340	COG1834	amidinotransferase
D6270_RS31355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D6270_RS31370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D6270_RS31395	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS31440	COG1191	sigma factor activity
D6270_RS31525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D6270_RS31540	COG0431	NADPH-dependent FMN reductase
D6270_RS31560	COG1609	Transcriptional regulator
D6270_RS31580	COG1129	ABC transporter
D6270_RS31590	COG1028	Short-chain dehydrogenase reductase Sdr
D6270_RS31590	COG3347	Dehydrogenase
D6270_RS31595	COG1070	Carbohydrate kinase
D6270_RS31600	COG3250	beta-galactosidase activity
D6270_RS31625	COG0477	Major facilitator Superfamily
D6270_RS31630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D6270_RS31640	COG0254	rRNA binding
D6270_RS31645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D6270_RS31650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D6270_RS31655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D6270_RS31675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS31680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D6270_RS31685	COG1120	ATPase activity
D6270_RS31715	COG1132	(ABC) transporter
D6270_RS31760	COG0438	transferase activity, transferring glycosyl groups
D6270_RS31840	COG1174	glycine betaine transport
D6270_RS31845	COG1174	glycine betaine transport
D6270_RS31860	COG1125	glycine betaine transport
D6270_RS31860	COG0517	IMP dehydrogenase activity
D6270_RS31870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D6270_RS31890	COG1960	acyl-CoA dehydrogenase activity
D6270_RS31895	COG1960	acyl-CoA dehydrogenase activity
D6270_RS31925	COG0395	ABC-type sugar transport system, permease component
D6270_RS31930	COG1175	transmembrane transport
D6270_RS31935	COG1653	transport
D6270_RS31950	COG0673	inositol 2-dehydrogenase activity
D6270_RS31955	COG1609	Transcriptional regulator
D6270_RS31975	COG3457	Alanine racemase
D6270_RS31980	COG0626	cystathionine gamma-synthase activity
D6270_RS31985	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D6270_RS32005	COG2188	Transcriptional regulator
D6270_RS32010	COG0395	ABC-type sugar transport system, permease component
D6270_RS32015	COG1175	transmembrane transport
D6270_RS32035	COG1609	Transcriptional regulator
D6270_RS32070	COG0601	transmembrane transport
D6270_RS32075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D6270_RS32080	COG0444	Belongs to the ABC transporter superfamily
D6270_RS32140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D6270_RS32140	COG1796	DNA polymerase
D6270_RS32230	COG1278	Cold shock
D6270_RS32245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D6270_RS32250	COG0693	protein deglycase activity
D6270_RS32265	COG4044	May play a role in the intracellular transport of hydrophobic ligands
D6270_RS32320	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D6270_RS32320	COG2066	Belongs to the glutaminase family
D6270_RS32325	COG2356	endonuclease I
D6270_RS32340	COG2813	Specifically methylates the guanine in position
D6270_RS32345	COG1960	acyl-CoA dehydrogenase activity
D6270_RS32355	COG0346	lactoylglutathione lyase activity
D6270_RS32360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D6270_RS32380	COG0515	serine threonine protein kinase